TY - JOUR T1 - Clinical heterogeneity in Hallervorden-Spatz syndrome: a clinicoradiological study in 13 patients from South India. AN - 85401651; pmid-16504438 AB - Hallervorden-Spatz syndrome (HSS) is a rare autosomal recessive neurodegenerative disorder of childhood. Thirteen patients with this syndrome seen over a period of 7 years were reviewed. Two distinct groups were identified. The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia. This group was also characterised by familial incidence, retinal involvement and absence of behavioural problems. Late onset group, included patients with different presentations such as behavioural changes, optic atrophy and dystonia. Consanguinity was prominent in this study, being present in 61.5% patients. MRI (n=11) showed pallidal hyperintensity on T1-weighted images and hypointensity or 'eye of the tiger' sign on T2-weighted images. Two patients had acanthocytes in peripheral blood smear. This study emphasizes the phenotypic heterogeneity in HSS and as well brings out the common features shared by patients with early onset disease. JF - Brain & development AU - Bindu, P S AU - Desai, Sunali AU - Shehanaz, K E AU - Nethravathy, M AU - Pal, Pramod K AD - Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore 560029, India. Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 343 EP - 347 VL - 28 IS - 6 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Age of Onset KW - Child KW - Child, Preschool KW - Dystonia: etiology KW - Dystonia: physiopathology KW - Dystonia: radiography KW - Female KW - Gait Apraxia: etiology KW - Gait Apraxia: physiopathology KW - Gait Apraxia: radiography KW - Globus Pallidus: physiopathology KW - Globus Pallidus: radiography KW - Humans KW - India KW - Magnetic Resonance Imaging KW - Male KW - Pantothenate Kinase-Associated Neurodegeneration: complications KW - *Pantothenate Kinase-Associated Neurodegeneration: physiopathology KW - *Pantothenate Kinase-Associated Neurodegeneration: radiography KW - Phenotype KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85401651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Clinical+heterogeneity+in+Hallervorden-Spatz+syndrome%3A+a+clinicoradiological+study+in+13+patients+from+South+India.&rft.au=Bindu%2C+P+S%3BDesai%2C+Sunali%3BShehanaz%2C+K+E%3BNethravathy%2C+M%3BPal%2C+Pramod+K&rft.aulast=Bindu&rft.aufirst=P&rft.date=2006-07-01&rft.volume=28&rft.issue=6&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Genetic polymorphisms of CYP2E1 and GSTM1 in a Thai population. AN - 68981379; 17059334 AB - Cytochrome P450 2E1 and GSTM1 play major roles in metabolic activation and detoxification of many carcinogens and polymorphisms in the encoding genes have been reported to be individually associated with increased susceptibility to certain cancer. In the present study, we investigated the RsaI, PstI and DraI polymorphisms of the CYP2E1 gene and the null GSTM1 genotype in a Thai population. DNA samples from 485 individuals were analysed by polymerase chain reaction with restriction fragment length (PCR/RFLP). The frequency of RsaI and PstI predominant homozygous alleles (c1/c1) was 73.2%, heterozygous allele (c1/c2) was 25.6% and rare homozygous allele (c2/c2) was 1.2%. For the DraI polymorphism, the frequency of the predominant allele (DD) was 59.6%, heterozygous (CD) was 40% and rare allele (CC) was 0.4%. The frequency of GSTM1 null genotype was 62.7%. The distribution and frequencies of these alleles showed different pattern from those found in Caucasian and some other Asian populations. With the large population in this study, we believed that our results are reliable estimates of the frequencies of the polymorphic CYP2E1 and GSTM1 alleles in Thai population and should provide a base for further epidemiological studies on their links with cancer development. JF - Asian Pacific journal of cancer prevention : APJCP AU - Sangrajrang, Suleeporn AU - Jedpiyawongse, Adisorn AU - Srivatanakul, Petcharin AD - Research Division, National Cancer Institute, Rajchathewee, Bangkok, Thailand 10400. sulee@health.moph.go.th PY - 2006 SP - 415 EP - 419 VL - 7 IS - 3 SN - 1513-7368, 1513-7368 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - CTGCAG-specific type II deoxyribonucleases KW - EC 3.1.21.4 KW - Deoxyribonucleases, Type II Site-Specific KW - GTAC-specific type II deoxyribonucleases KW - TTTAAA -specific type II deoxyribonucleases KW - Index Medicus KW - Genotype KW - Asian Continental Ancestry Group KW - Alleles KW - Polymorphism, Restriction Fragment Length KW - Thailand KW - Humans KW - European Continental Ancestry Group KW - Adult KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Deoxyribonucleases, Type II Site-Specific -- metabolism KW - Polymorphism, Genetic KW - Glutathione Transferase -- genetics KW - Cytochrome P-450 CYP2E1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68981379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Genetic+polymorphisms+of+CYP2E1+and+GSTM1+in+a+Thai+population.&rft.au=Sangrajrang%2C+Suleeporn%3BJedpiyawongse%2C+Adisorn%3BSrivatanakul%2C+Petcharin&rft.aulast=Sangrajrang&rft.aufirst=Suleeporn&rft.date=2006-07-01&rft.volume=7&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo. AN - 68746702; 16910774 AB - SCCVII tumor cells that grow in vitro or in vivo as a solid tumor were used to compare and contrast geneexpression profiles with or without exposure to two doses of ionizing radiation. Exponentially growing SCCVII cell cultures and tumors (1 cm diameter) were treated with 0, 2, or 10 Gy, and RNA was collected 1, 3, 6, 12, and 24 h after treatment. Growth under in vitro conditions increased the expression of genes associated with the unfolded protein response (UPR) including ATF4, Ero-1 like, and cystathionase. Growth in vivo indicated that the HIF-1a genes were not upregulated, whereas genes such as hemoglobin alpha and crystallin alpha B were significantly upregulated. Ninety genes of 16K were found to be significantly modulated under either growth condition by radiation treatment. Gene expression was not dose dependent. Sixty percent of these genes exhibited similar modulation under both in vitro and in vivo conditions; however, 29% of the genes were modulated by radiation under in vivo conditions only. Gene-expression profiles for the same tumor cells can differ, dependent on growth conditions, underscoring the influence that the tumor microenvironment exerts on gene expression for both growth of solid tumors and their response to radiation treatment. JF - Antioxidants & redox signaling AU - Cook, John A AU - Chuang, Eric Y AU - Tsai, Mong-Hsun AU - Coffin, Debbie AU - Degraff, William AU - Sowers, Anastasia L AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. cook@helix.nih.gov PY - 2006 SP - 1263 EP - 1272 VL - 8 IS - 7-8 SN - 1523-0864, 1523-0864 KW - Tumor Suppressor Protein p53 KW - 0 KW - Index Medicus KW - Neoplasm Transplantation KW - Radiation Dosage KW - Animals KW - Tumor Suppressor Protein p53 -- analysis KW - Mice, Inbred C3H KW - Cell Culture Techniques KW - Mice KW - Cell Line, Tumor KW - Cell Survival -- radiation effects KW - Cell Cycle -- radiation effects KW - Time Factors KW - Female KW - Radiation, Ionizing KW - Gene Expression Profiling KW - Carcinoma, Squamous Cell -- pathology KW - Neoplasms, Experimental -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Xenograft Model Antitumor Assays KW - Gene Expression Regulation, Neoplastic -- radiation effects KW - Neoplasms, Experimental -- radiotherapy KW - Neoplasms, Experimental -- pathology KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68746702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Radiation-induced+changes+in+gene-expression+profiles+for+the+SCC+VII+tumor+cells+grown+in+vitro+and+in+vivo.&rft.au=Cook%2C+John+A%3BChuang%2C+Eric+Y%3BTsai%2C+Mong-Hsun%3BCoffin%2C+Debbie%3BDegraff%2C+William%3BSowers%2C+Anastasia+L%3BMitchell%2C+James+B&rft.aulast=Cook&rft.aufirst=John&rft.date=2006-07-01&rft.volume=8&rft.issue=7-8&rft.spage=1263&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=15230864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experience-dependent regulation of zif268 gene expression and spatial learning. AN - 68667045; 16545374 AB - Environmental enrichment (EE) is known to enhance the cognitive ability of rodents. To translate EE to the human condition, it is important to understand the parameters of its efficacy. In this study, we examine if the cognitive enhancement associated with EE is permanent and whether a developmental window exists for its efficacy. Rats were housed in continuous isolation (ISO), continuous enrichment (EE), enrichment from postnatal day (PN) 21-50, and then isolation from PN50-79 (PM), or isolation from PN21-50 and then enriched from PN50-79 (CW). Spatial learning ability and basal expression of the immediate-early genes zif268 and Arc as well as the NR1 subunit of the NMDA receptor were assessed. Rats housed in an enriched environment at the time of testing (EE and CW) performed significantly better in the spatial learning task than rats housed in an isolated environment at the time of testing (ISO and PM). Enhanced performance in the spatial learning task was associated with a higher expression of zif268 only in the CA3/CA4 region of the hippocampus. Our study further defines parameters that make environmental enrichment effective in enhancing learning performance and the findings may be helpful in the translation of this intervention to the human condition. JF - Experimental neurology AU - Toscano, Christopher D AU - McGlothan, Jennifer L AU - Guilarte, Tomás R AD - Molecular Neurotoxicology Laboratory, Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. toscanoc@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 209 EP - 215 VL - 200 IS - 1 SN - 0014-4886, 0014-4886 KW - Early Growth Response Protein 1 KW - 0 KW - Egr1 protein, rat KW - Index Medicus KW - Up-Regulation -- physiology KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Long-Evans KW - Social Isolation KW - Male KW - Female KW - Pregnancy KW - Gene Expression Regulation, Developmental -- physiology KW - Spatial Behavior -- physiology KW - Learning -- physiology KW - Early Growth Response Protein 1 -- biosynthesis KW - Early Growth Response Protein 1 -- genetics KW - Social Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68667045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Experience-dependent+regulation+of+zif268+gene+expression+and+spatial+learning.&rft.au=Toscano%2C+Christopher+D%3BMcGlothan%2C+Jennifer+L%3BGuilarte%2C+Tom%C3%A1s+R&rft.aulast=Toscano&rft.aufirst=Christopher&rft.date=2006-07-01&rft.volume=200&rft.issue=1&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug development in oncology: classical cytotoxics and molecularly targeted agents. AN - 68642101; 16842375 AB - There is an apparent need to improve the speed and efficiency of oncological drug development. Furthermore, strategies traditionally applied to the development of standard cytotoxic chemotherapy may not be appropriate for molecularly targeted agents. This is particularly the case for exploratory Phase 1 and 2 trials. Conventional approaches to determine dose based on maximum tolerability and efficacy based on objective tumour response may not be suitable for targeted agents, since many of them have a wide therapeutic index and inhibit tumour growth without demonstrable cytotoxicity. Instead, exploratory trials of targeted agents may have to focus on other end-points such as pharmacological effects and disease stabilization. Thus, there is an increasing interest in making the best possible use of biomarkers and pharmacogenomics in early phases of drug development. JF - British journal of clinical pharmacology AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Doroshow, James H AU - Murgo, Anthony J AD - Medical Oncology Branch, Center for Cancer Research and Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 15 EP - 26 VL - 62 IS - 1 SN - 0306-5251, 0306-5251 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Drug Delivery Systems KW - Drug Interactions KW - Technology, Pharmaceutical KW - Humans KW - Clinical Trials, Phase I as Topic KW - Drug Design KW - Pharmacogenetics KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68642101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+clinical+pharmacology&rft.atitle=Drug+development+in+oncology%3A+classical+cytotoxics+and+molecularly+targeted+agents.&rft.au=Kummar%2C+Shivaani%3BGutierrez%2C+Martin%3BDoroshow%2C+James+H%3BMurgo%2C+Anthony+J&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2006-07-01&rft.volume=62&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=British+journal+of+clinical+pharmacology&rft.issn=03065251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 1989 Sep;45(3):925-37 [2790129] J Clin Oncol. 2005 Dec 20;23(36):9359-68 [16361636] J Natl Cancer Inst. 1990 Aug 15;82(16):1321-6 [2143234] Oncology (Williston Park). 1989 Jul;3(7):43-9; discussion 51-3 [2701811] Invest New Drugs. 1991 Aug;9(3):219-25 [1783521] Stat Med. 1996 Aug 15;15(15):1605-18 [8858785] J Natl Cancer Inst. 1997 Aug 6;89(15):1138-47 [9262252] Cancer Chemother Pharmacol. 1998;41(3):173-85 [9443633] Clin Cancer Res. 1998 May;4(5):1079-86 [9607564] Cancer Res. 1999 May 15;59(10):2402-10 [10344750] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Invest New Drugs. 2000 Feb;18(1):7-16 [10830137] Clin Cancer Res. 2002 Apr;8(4):935-8 [11948095] J Clin Oncol. 2002 May 15;20(10):2495-9 [12011127] J Natl Cancer Inst. 2002 Aug 21;94(16):1247-9 [12189228] Blood. 2002 Oct 15;100(8):3041-4 [12351420] Oncologist. 2002;7(5):401-9 [12401902] J Clin Oncol. 2002 Nov 15;20(22):4478-84 [12431972] J Clin Oncol. 2003 Apr 1;21(7):1404-11 [12663734] Nat Rev Cancer. 2003 Apr;3(4):303-9 [12671669] Nat Rev Cancer. 2003 Jul;3(7):540-5 [12835674] Lancet. 2003 Jul 5;362(9377):62-4 [12853203] J Clin Oncol. 2003 Jul 15;21(14):2664-72 [12860942] J Clin Oncol. 2003 Aug 1;21(15):2807-9 [12807933] Semin Oncol. 2003 Aug;30(4 Suppl 15):14-9 [14523790] Oncogene. 2003 Sep 29;22(42):6621-8 [14528287] J Clin Oncol. 2003 Nov 1;21(21):3955-64 [14517187] Jpn J Clin Oncol. 2003 Oct;33(10):533-7 [14623923] J Clin Oncol. 2003 Dec 1;21(23):4342-9 [14645423] Nat Rev Cancer. 2003 Dec;3(12):912-20 [14740638] Neuro Oncol. 2004 Jan;6(1):44-54 [14769140] N Engl J Med. 2004 May 20;350(21):2129-39 [15118073] Nature. 2004 May 27;429(6990):464-8 [15164072] Clin Cancer Res. 2004 Jun 1;10(11):3881-4 [15173097] Clin Cancer Res. 2004 Jun 1;10(11):3885-96 [15173098] Lancet Oncol. 2004 Aug;5(8):489-96 [15288238] Nat Rev Drug Discov. 2004 Sep;3(9):785-96 [15340388] Cancer Treat Rep. 1986 Jan;70(1):73-80 [3753662] J Natl Cancer Inst. 1999 Aug 4;91(15):1281-7 [10433616] Cancer Chemother Pharmacol. 2005 Jun;55(6):552-8 [15856233] Br J Clin Pharmacol. 2005 Jul;60(1):1-4 [15963086] Stat Med. 2005 Jul 30;24(14):2171-81 [15909289] N Engl J Med. 2005 Jul 14;353(2):200-2 [16014890] Crit Rev Oncol Hematol. 2005 Aug;55(2):117-42 [15890526] J Chemother. 2005 Jun;17(3):339-42 [16038530] J Clin Oncol. 2005 Aug 1;23(22):5094-8 [15983399] Cancer Res. 2005 Aug 15;65(16):7041-4 [16103049] J Clin Oncol. 2005 Aug 20;23(24):5417-9 [16027435] J Clin Oncol. 2005 Aug 20;23(24):5464-73 [16027440] J Clin Oncol. 2005 Sep 20;23(27):6647-56 [16170172] Breast Cancer Res Treat. 2005 Sep;93(1):3-11 [16184453] J Clin Oncol. 2005 Oct 1;23(28):7199-206 [16192604] Invest New Drugs. 2005 Dec;23(6):539-45 [16267624] Cancer Chemother Pharmacol. 2006 Jun;57(6):761-71 [16172907] Clin Cancer Res. 2006 Aug 15;12(16):4899-907 [16914578] Lancet Oncol. 2005 Oct;6(10):780-9 [16198984] Arch Intern Med. 2005 Nov 14;165(20):2331-6 [16287761] Clin Cancer Res. 2005 Nov 15;11(22):7967-85 [16299226] Biometrics. 1990 Mar;46(1):33-48 [2350571] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neural progenitors and HIV-1-associated central nervous system disease in adults and children. AN - 68637534; 16842084 AB - The human immunodeficiency virus type 1 (HIV-1) is a neurotrophic lentivirus that enters and infects the central nervous system (CNS) of adults and children, giving rise to the clinical syndromes of AIDS-dementia complex (ADC) in adults and HIV-1-associated progressive encephalopathy (PE) in pediatric patients. The clinical presentation and progression of neuroAIDS in the developing brain of children is distinct from that seen in adult patients. Neuroimaging, and upon autopsy, neuropathological findings corresponding to clinical disease in pediatric patients include impaired brain growth, reactive gliosis, myelin pallor, calcifications of the basal ganglia, cortical and cerebral atrophy with neuronal loss and ventricular enlargement, and abnormalities of cerebral vasculature. Although there is some overlap with neuropathologic findings in adult patients, ADC in adults is more typically a late development, often complicated by opportunistic infections of the CNS. The neuropathogenesis of ADC and PE is incompletely understood. One population of CNS cells critical for brain development and response to injury and inflammation are neural progenitors cells, and it has therefore been suggested that these cells may be involved in the neuropathogenesis of ADC, and especially PE. This review examines the neurobiology of neural progenitor cells and the possibility that HIV-1 infection of neural progenitors, exposure of neural progenitors to virus, viral products, or progenitor exposure to HIV-1 associated neuroinflammatory substances and neurotoxins might contribute to the neuropathogenesis of AIDS in adults and children. That some of the clinical differences between ADC and PE might, in part, be explained by differences in neural progenitor involvement will also be considered. JF - Current HIV research AU - Schwartz, Lynnae AU - Major, Eugene O AD - Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. schwartl@ninds.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 319 EP - 327 VL - 4 IS - 3 SN - 1570-162X, 1570-162X KW - CXCL12 protein, human KW - 0 KW - Chemokine CXCL12 KW - Chemokines, CXC KW - Receptors, CXCR4 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Receptors, CXCR4 -- physiology KW - Chemokines, CXC -- physiology KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Adult KW - Child KW - AIDS Dementia Complex -- etiology KW - Neurons -- physiology KW - Stem Cells -- physiology KW - Neurons -- virology KW - Stem Cells -- virology KW - HIV-1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68637534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV+research&rft.atitle=Neural+progenitors+and+HIV-1-associated+central+nervous+system+disease+in+adults+and+children.&rft.au=Schwartz%2C+Lynnae%3BMajor%2C+Eugene+O&rft.aulast=Schwartz&rft.aufirst=Lynnae&rft.date=2006-07-01&rft.volume=4&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Current+HIV+research&rft.issn=1570162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. AN - 68610120; 16818861 AB - Childhood-onset schizophrenia is a rare but severe form of the disorder that is frequently treatment resistant. The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment. To compare the efficacy and safety of olanzapine and clozapine, hypothesizing that clozapine would be more efficacious. Double-blind randomized 8-week controlled trial, with a 2-year open-label follow-up. National Institute of Mental Health study, January 1998 to June 2005. Patients underwent reassessment 2 years after discharge. Children and adolescents recruited nationally, aged 7 to 16 years, meeting unmodified DSM-IV criteria for schizophrenia, and resistant to treatment with at least 2 antipsychotics. After drug washout and a 1- to 3-week antipsychotic-free period, patients were randomized to treatment with clozapine (n = 12) or olanzapine (n = 13). The Clinical Global Impression Severity of Symptoms Scale and Schedule for the Assessment of Negative/Positive Symptoms. Clozapine was associated with a significant reduction in all outcome measures, whereas olanzapine showed a less consistent profile of clinical improvement. While there were moderate to large differential treatment effects in favor of clozapine, these reached significance only in the alleviation of negative symptoms from an antipsychotic-free baseline (P = .04; effect size, 0.89). Clozapine was associated with more overall adverse events. At 2-year follow-up, 15 patients were receiving clozapine with evidence of sustained clinical improvement, but additional adverse events emerged, including lipid anomalies (n = 6) and seizures (n = 1). While not demonstrating definitively the superiority of clozapine compared with olanzapine in treatment-refractory childhood-onset schizophrenia, the study suggests that clozapine has a more favorable profile of clinical response, which is balanced against more associated adverse events. JF - Archives of general psychiatry AU - Shaw, Philip AU - Sporn, Alex AU - Gogtay, Nitin AU - Overman, Gerald P AU - Greenstein, Deanna AU - Gochman, Peter AU - Tossell, Julia W AU - Lenane, Marge AU - Rapoport, Judith L AD - Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892-1500, USA. shawp@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 721 EP - 730 VL - 63 IS - 7 SN - 0003-990X, 0003-990X KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Clozapine KW - J60AR2IKIC KW - olanzapine KW - N7U69T4SZR KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Benzodiazepines -- therapeutic use KW - Drug Administration Schedule KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Benzodiazepines -- adverse effects KW - Age of Onset KW - Humans KW - Treatment Outcome KW - Schizophrenic Psychology KW - Follow-Up Studies KW - Child KW - Longitudinal Studies KW - Adolescent KW - Male KW - Female KW - Clozapine -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- diagnosis KW - Schizophrenia -- drug therapy KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68610120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Childhood-onset+schizophrenia%3A+A+double-blind%2C+randomized+clozapine-olanzapine+comparison.&rft.au=Shaw%2C+Philip%3BSporn%2C+Alex%3BGogtay%2C+Nitin%3BOverman%2C+Gerald+P%3BGreenstein%2C+Deanna%3BGochman%2C+Peter%3BTossell%2C+Julia+W%3BLenane%2C+Marge%3BRapoport%2C+Judith+L&rft.aulast=Shaw&rft.aufirst=Philip&rft.date=2006-07-01&rft.volume=63&rft.issue=7&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-03 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age at drinking onset and alcohol dependence: age at onset, duration, and severity. AN - 68609542; 16818840 AB - To examine whether starting to drink at an early age is associated with developing alcohol dependence at a younger age and chronic relapsing dependence, controlling for respondent demographics, smoking and illicit drug use, childhood antisocial behavior and depression, and family alcoholism history. Cross-sectional survey. Nationwide face-to-face survey with a multistage probability sample. A total of 43,093 adults were surveyed in 2001-2002. Based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria, lifetime alcohol dependence, dependence within 10 years of starting drinking, multiple episodes, an alcohol dependence episode in the past year, episodes exceeding 1 year, and meeting 6 or 7 dependence criteria. Relative to respondents who began drinking at 21 years or older, those who began drinking before age 14 years were more likely to experience alcohol dependence ever and within 10 years of first drinking (adjusted hazard ratios and 95% confidence intervals [CIs], 1.78 [1.51-2.11] and 1.69 [1.38-2.07], respectively). They also more often experienced past-year dependence and multiple dependence episodes (adjusted odds ratios, 1.93 [95% CI, 1.40-2.64] and 3.09 [95% CI, 2.19-4.35], respectively). Among alcohol-dependent persons, the odds were 2.62 (95% CI, 1.79-3.84) for having at least 1 episode exceeding 1 year and 2.89 (95% CI, 1.97-4.23) for meeting 6 or 7 dependence diagnostic criteria. There is a need to screen and counsel adolescents about alcohol use and to implement policies and programs that delay alcohol consumption. JF - Archives of pediatrics & adolescent medicine AU - Hingson, Ralph W AU - Heeren, Timothy AU - Winter, Michael R AD - Youth Alcohol Prevention Center, Boston University School of Public Health, Boston, Mass 02118, USA. rhingson@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 739 EP - 746 VL - 160 IS - 7 SN - 1072-4710, 1072-4710 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Cross-Sectional Studies KW - Humans KW - Health Surveys KW - Adult KW - Adolescent KW - Time Factors KW - Risk Assessment KW - Alcoholism -- etiology KW - Age Factors KW - Alcohol Drinking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68609542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pediatrics+%26+adolescent+medicine&rft.atitle=Age+at+drinking+onset+and+alcohol+dependence%3A+age+at+onset%2C+duration%2C+and+severity.&rft.au=Hingson%2C+Ralph+W%3BHeeren%2C+Timothy%3BWinter%2C+Michael+R&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2006-07-01&rft.volume=160&rft.issue=7&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Archives+of+pediatrics+%26+adolescent+medicine&rft.issn=10724710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-08 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. AN - 68598660; 16793869 AB - Melanin plays an important role in protecting the skin against UV radiation, and melanomas and basal/squamous cell carcinomas occur more frequently in individuals with fair/light skin. We previously reported that levels of melanin correlate inversely with amounts of DNA damage induced by UV in normal human skin of different racial/ethnic groups. We have now separately examined DNA damage in the upper and lower epidermal layers in various types of skin before and after exposure to UV and have measured subsequent apoptosis and phosphorylation of p53. The results show that two major mechanisms underlie the increased photocarcinogenesis in fair/light skin. First, UV-induced DNA damage in the lower epidermis (including keratinocyte stem cells and melanocytes) is more effectively prevented in darker skin, suggesting that the pigmented epidermis is an efficient UV filter. Second, UV-induced apoptosis is significantly greater in darker skin, which suggests that UV-damaged cells may be removed more efficiently in pigmented epidermis. The combination of decreased DNA damage and more efficient removal of UV-damaged cells may play a critical role in the decreased photocarcinogenesis seen in individuals with darker skin. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Yamaguchi, Yuji AU - Takahashi, Kaoruko AU - Zmudzka, Barbara Z AU - Kornhauser, Andrija AU - Miller, Sharon A AU - Tadokoro, Taketsugu AU - Berens, Werner AU - Beer, Janusz Z AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Institutes of Health, Bldg. 37, Rm. 2132, Bethesda, Maryland 20892-4254, USA. \ Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1486 EP - 1488 VL - 20 IS - 9 KW - Index Medicus KW - Ethnic Groups KW - DNA Damage KW - Humans KW - Continental Population Groups KW - Adult KW - Skin Neoplasms -- diagnostic imaging KW - Biopsy KW - Dose-Response Relationship, Radiation KW - Patient Selection KW - Skin Neoplasms -- prevention & control KW - Pigmentation -- radiation effects KW - Radionuclide Imaging KW - Epidermis -- physiology KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Radiation Protection KW - Epidermis -- cytology KW - Apoptosis -- radiation effects KW - Skin -- cytology KW - Epidermis -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68598660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Human+skin+responses+to+UV+radiation%3A+pigment+in+the+upper+epidermis+protects+against+DNA+damage+in+the+lower+epidermis+and+facilitates+apoptosis.&rft.au=Yamaguchi%2C+Yuji%3BTakahashi%2C+Kaoruko%3BZmudzka%2C+Barbara+Z%3BKornhauser%2C+Andrija%3BMiller%2C+Sharon+A%3BTadokoro%2C+Taketsugu%3BBerens%2C+Werner%3BBeer%2C+Janusz+Z%3BHearing%2C+Vincent+J&rft.aulast=Yamaguchi&rft.aufirst=Yuji&rft.date=2006-07-01&rft.volume=20&rft.issue=9&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-31 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic variability and the miracle of modern analytical chemistry. AN - 68593045; 16810094 JF - Epidemiology (Cambridge, Mass.) AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. longnec1@niehs.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 350 EP - 351 VL - 17 IS - 4 SN - 1044-3983, 1044-3983 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Humans KW - Cohort Studies KW - Body Mass Index KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Male KW - Female KW - Chemistry Techniques, Analytical -- methods KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68593045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Pharmacokinetic+variability+and+the+miracle+of+modern+analytical+chemistry.&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2006-07-01&rft.volume=17&rft.issue=4&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Epidemiology. 2006 Jul;17(4):352-9 [16755267] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aspirin use and miscarriage risk. AN - 68592947; 16755260 AB - Recent research has found nonsteroidal antiinflammatory drugs, including aspirin, to increase the risk of miscarriage. The objective of the present study was to evaluate the association between aspirin use and miscarriage. We conducted a case-control study using data from the Collaborative Perinatal Project. This prospective cohort study recruited approximately 54,000 pregnant women at 12 sites in the United States from 1959 to 1965. Women who had miscarriages (n = 542) were matched by clinic and time in pregnancy when they came under observation to 2587 women who had live births. Participants were interviewed at each prenatal visit. Data on aspirin use were collected prospectively by in-person interviews and medical record review. Aspirin use among controls was considered only for the duration of pregnancy when the matched cases remained pregnant. The outcome of interest was miscarriage, defined as spontaneous pregnancy loss at less than 140 days from the last menstrual period. Twenty-nine percent of cases and 34% of controls used aspirin during pregnancy. Aspirin use was not associated with an increased risk of miscarriage. Adjusted odds ratios ranged from 0.64 to 0.92 (95% confidence intervals = 0.48-1.38) for individual lunar months and combinations of lunar months. Use of aspirin during pregnancy is not associated with an increased risk of miscarriage. JF - Epidemiology (Cambridge, Mass.) AU - Keim, Sarah A AU - Klebanoff, Mark A AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. keims@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 435 EP - 439 VL - 17 IS - 4 SN - 1044-3983, 1044-3983 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Pregnancy Trimester, Second KW - Odds Ratio KW - Prospective Studies KW - Pregnancy Trimester, First KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Abortion, Spontaneous -- chemically induced KW - Aspirin -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Aspirin+use+and+miscarriage+risk.&rft.au=Keim%2C+Sarah+A%3BKlebanoff%2C+Mark+A&rft.aulast=Keim&rft.aufirst=Sarah&rft.date=2006-07-01&rft.volume=17&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk of non-Hodgkin lymphoma and nitrate and nitrite from drinking water and diet. AN - 68592229; 16699473 AB - Nitrate and nitrite are precursors in the in vivo formation of N-nitroso compounds, potent animal carcinogens. We conducted a population-based case-control study of non-Hodgkin lymphoma (NHL) in 1998 to 2000 in Iowa, Detroit, Seattle, and Los Angeles. Because nitrate levels were elevated in many drinking water supplies in Iowa, but not in the other study centers, we evaluated water nitrate levels and risk of NHL in Iowa only. Monitoring data for public supplies were linked to water source histories from 1960 onward. Nitrate was measured at interview homes with private wells. We limited most analyses to those with nitrate estimates for > 70% of their person-years since 1960 (181 cases, 142 controls). For those in the diet arm of the study (458 cases, 383 controls from 4 centers) and for Iowa participants in both the diet and drinking water analyses, we estimated dietary nitrate and nitrite intake using a 117-item food-frequency questionnaire that included foods high in nitrate and nitrite. Odds ratios and 95% confidence intervals were calculated using logistic regression, adjusting for the study matching factors, education, and caloric intake (diet analyses only). We found no overall association with the highest quartile of average drinking water nitrate (> 2.90 mg/L nitrate-N: odds ratios = 1.2; 95% confidence interval = 0.6-2.2) or with years > or = 5 mg/L (10+ years: 1.4; 0.7-2.9). We observed no evidence of an interaction between drinking water nitrate exposure and either vitamin C or red meat intake, an inhibitor and precursor, respectively, of N-nitroso compound formation. Among those in the diet arm, dietary nitrate was inversely associated with risk of NHL (highest quartile: 0.54; 0.34-0.86). Dietary nitrite intake was associated with increasing risk (highest quartile: 3.1; 1.7-5.5) largely due to intakes of bread and cereal sources of nitrite. Average drinking water nitrate levels below 3 mg/L were not associated with NHL risk. Our study had limited power to evaluate higher levels that deserve further study. JF - Epidemiology (Cambridge, Mass.) AU - Ward, Mary H AU - Cerhan, James R AU - Colt, Joanne S AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. wardm@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 375 EP - 382 VL - 17 IS - 4 SN - 1044-3983, 1044-3983 KW - Nitrates KW - 0 KW - Nitrites KW - Water Pollutants, Chemical KW - Index Medicus KW - Risk KW - Los Angeles -- epidemiology KW - Washington -- epidemiology KW - Humans KW - SEER Program KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Michigan -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Water Supply -- analysis KW - Water Pollutants, Chemical -- adverse effects KW - Nitrites -- adverse effects KW - Lymphoma, Non-Hodgkin -- etiology KW - Nitrates -- adverse effects KW - Diet -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Risk+of+non-Hodgkin+lymphoma+and+nitrate+and+nitrite+from+drinking+water+and+diet.&rft.au=Ward%2C+Mary+H%3BCerhan%2C+James+R%3BColt%2C+Joanne+S%3BHartge%2C+Patricia&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-07-01&rft.volume=17&rft.issue=4&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. AN - 68584716; 16597643 AB - Increased visceral adipose tissue results in elevated plasma leptin, which are associated with increased risk of a number of obesity-related cancers. However, research is contradictory regarding the role of elevated plasma leptin in colon cancer risk. Having established that leptin induced proliferation in a murine model of preneoplastic (Apc(Min/+); IMCE) colon epithelial cells but not normal (Apc(+/+); YAMC) cells, we hypothesized that the leptin-associated IMCE cell proliferation was a result of autocrine interleukin-6 (IL-6) production and ensuing IL-6 receptor (IL-6R) signaling. Here we show, for the first time, that leptin induces elevated IL-6 production in IMCE cells but not in YAMC cells. IL-6 treatment induced cell proliferation in IMCE cells, but not in YAMC cells, in a concentration-dependent manner from 0.1 to 100 ng/ml (P < 0.05). Interleukin-6-induced IMCE cell proliferation was blocked by the addition of a neutralizing anti-IL-6R antibody. In addition, leptin-induced IMCE cell proliferation was blocked by the addition of an anti-IL-6R neutralizing antibody. Further, we elucidate a novel mechanism by which leptin activates TACE/ADAM17-associated IL-6R shedding and trans-IL-6 signaling in IMCE by induction of IL-6 production. IL-6 treatment of IMCE cells was associated with STAT3, ERK, p38, MEK and JAK2 activation and associated STAT3 nuclear activation and translocation. These data implicate leptin-induced IL-6 production, signaling and subsequent STAT3 activation as early events promoting the survival/proliferation of colon epithelial preneoplastic cells. The elucidation of the leptin-initiated mechanism of preneoplastic cell proliferation establishes a biologically plausible link between the adipocyte-specific cytokine leptin and obesity-associated colon cancer. JF - Carcinogenesis AU - Fenton, Jenifer I AU - Hursting, Stephen D AU - Perkins, Susan N AU - Hord, Norman G AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7361, USA. imigjeni@msu.edu Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1507 EP - 1515 VL - 27 IS - 7 SN - 0143-3334, 0143-3334 KW - Interleukin-6 KW - 0 KW - Leptin KW - Proto-Oncogene Proteins KW - Receptors, Interleukin-6 KW - Receptors, Leptin KW - STAT3 Transcription Factor KW - Stat3 protein, mouse KW - leptin receptor, mouse KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Jak2 protein, mouse KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - p38 Mitogen-Activated Protein Kinases KW - ADAM Proteins KW - EC 3.4.24.- KW - ADAM17 Protein KW - EC 3.4.24.86 KW - Adam17 protein, mouse KW - Index Medicus KW - ADAM Proteins -- drug effects KW - Animals KW - Protein-Tyrosine Kinases -- drug effects KW - Colon -- drug effects KW - Proto-Oncogene Proteins -- metabolism KW - Mice, Transgenic KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Extracellular Signal-Regulated MAP Kinases -- drug effects KW - Genes, APC KW - ADAM Proteins -- metabolism KW - STAT3 Transcription Factor -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - p38 Mitogen-Activated Protein Kinases -- drug effects KW - Protein Transport -- physiology KW - Cell Proliferation -- drug effects KW - Protein Transport -- drug effects KW - Mice KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Protein-Tyrosine Kinases -- metabolism KW - Obesity -- complications KW - Blotting, Western KW - Epithelial Cells -- drug effects KW - Proto-Oncogene Proteins -- drug effects KW - STAT3 Transcription Factor -- metabolism KW - Obesity -- physiopathology KW - Receptors, Interleukin-6 -- metabolism KW - Cell Line KW - Signal Transduction -- physiology KW - Precancerous Conditions -- genetics KW - Signal Transduction -- drug effects KW - Interleukin-6 -- metabolism KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects KW - Precancerous Conditions -- metabolism KW - Leptin -- pharmacology KW - Precancerous Conditions -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68584716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Interleukin-6+production+induced+by+leptin+treatment+promotes+cell+proliferation+in+an+Apc+%28Min%2F%2B%29+colon+epithelial+cell+line.&rft.au=Fenton%2C+Jenifer+I%3BHursting%2C+Stephen+D%3BPerkins%2C+Susan+N%3BHord%2C+Norman+G&rft.aulast=Fenton&rft.aufirst=Jenifer&rft.date=2006-07-01&rft.volume=27&rft.issue=7&rft.spage=1507&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. AN - 68583556; 16399771 AB - Polymorphisms exist in several genes involved in nucleotide excision repair (NER), the principal pathway for removal of smoking-induced DNA damage. An epidemiologic study was conducted to determine whether these polymorphisms modify the association between smoking and breast cancer. DNA samples and exposure histories were analyzed as part of a large population-based case-control study of breast cancer in North Carolina. The study population included 2311 cases (894 African Americans, 1417 whites) and 2022 controls (788 African Americans, 1234 whites). Odds ratios (ORs) were calculated for breast cancer and smoking, and for breast cancer and nine non-synonymous coding polymorphisms in six NER genes (XPD codons 312 and 751, RAD23B codon 249, XPG codon 1104, XPC codon 939, XPF codons 415 and 662, and ERCC6 codons 1213 and 1230). Modification of ORs for smoking by single and combined NER genotypes was investigated. In this study population, smoking was more strongly associated with breast cancer in African American women compared with white women. Among African American women, the association of breast cancer and smoking was strongest among women with specific combinations of NER genotypes. Evidence for multiplicative interaction was found between combined NER genotypes and smoking dose (likelihood ratio test P = 0.06), duration (P = 0.09), time since cessation (P = 0.02), age at initiation (P = 0.04) and former smoking (P = 0.03). No interactions were observed in white women. Therefore, polymorphisms in NER genes may modify the relationship between breast cancer and smoking. These results are consistent with previous evidence of exposure-specific p53 mutations in breast tumors from current and former smokers, suggesting that smoking may play a role in breast cancer etiology. JF - Carcinogenesis AU - Mechanic, Leah E AU - Millikan, Robert C AU - Player, Jon AU - de Cotret, Allan René AU - Winkel, Scott AU - Worley, Kendra AU - Heard, Kristin AU - Heard, Kimberley AU - Tse, Chiu-Kit AU - Keku, Temitope AD - Laboratory of Human Carcinogenesis, NCI/NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892-4255, USA. mechanil@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1377 EP - 1385 VL - 27 IS - 7 SN - 0143-3334, 0143-3334 KW - Index Medicus KW - Genotype KW - Polymerase Chain Reaction KW - Odds Ratio KW - Polymorphism, Genetic KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- ethnology KW - Breast Neoplasms -- etiology KW - Smoking -- adverse effects KW - African Americans -- genetics KW - European Continental Ancestry Group -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68583556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+nucleotide+excision+repair+genes%2C+smoking+and+breast+cancer+in+African+Americans+and+whites%3A+a+population-based+case-control+study.&rft.au=Mechanic%2C+Leah+E%3BMillikan%2C+Robert+C%3BPlayer%2C+Jon%3Bde+Cotret%2C+Allan+Ren%C3%A9%3BWinkel%2C+Scott%3BWorley%2C+Kendra%3BHeard%2C+Kristin%3BHeard%2C+Kimberley%3BTse%2C+Chiu-Kit%3BKeku%2C+Temitope&rft.aulast=Mechanic&rft.aufirst=Leah&rft.date=2006-07-01&rft.volume=27&rft.issue=7&rft.spage=1377&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for the incidence of endometrial cancer according to the aggressiveness of disease. AN - 68099158; 16675538 AB - There is a wide range of aggressiveness of endometrial tumors, some being indolent and easily treated while others metastasize and prove fatal. The authors used data from three population-based, case-control studies to determine if etiologic factors differ for aggressive disease. Interview data were obtained from 1,304 female residents of western Washington State who were 45-74 years of age and diagnosed with endometrial cancer during 1985-1991, 1994-1995, and 1997-1999 and from 1,779 controls who were of similar ages and selected primarily by random digit dialing. As a means of gauging aggressiveness, tumor characteristics were abstracted from the population-based cancer registry that serves western Washington State. The risk of endometrial cancer among long-term users (> or = 8 years) of unopposed estrogens was particularly high for the least aggressive tumors (odds ratio = 18.6, 95% confidence interval: 12.2, 28.6) but was elevated for moderate and highly aggressive tumors as well (odds ratios = 6.6 and 7.1, respectively). Women who were obese, had a history of diabetes, and had fewer than two children were also at increased risk, regardless of tumor aggressiveness, while oral contraceptive users were at decreased risk of only relatively more aggressive disease. In general, a woman's risk of endometrial cancer appears to be influenced by similar risk factors regardless of disease severity. JF - American journal of epidemiology AU - Weiss, Jocelyn M AU - Saltzman, Babette S AU - Doherty, Jennifer A AU - Voigt, Lynda F AU - Chen, Chu AU - Beresford, Shirley A A AU - Hill, Deirdre A AU - Weiss, Noel S AD - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. weissjoc@mail.nih.gov Y1 - 2006/07/01/ PY - 2006 DA - 2006 Jul 01 SP - 56 EP - 62 VL - 164 IS - 1 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Disease Progression KW - Aged KW - Body Mass Index KW - Risk Assessment KW - Obesity -- complications KW - Registries KW - Washington -- epidemiology KW - Postmenopause KW - Logistic Models KW - Risk Factors KW - Surveys and Questionnaires KW - Case-Control Studies KW - Confidence Intervals KW - Incidence KW - Interviews as Topic KW - Middle Aged KW - Female KW - Endometrial Neoplasms -- chemically induced KW - Estrogen Replacement Therapy -- adverse effects KW - Endometrial Neoplasms -- epidemiology KW - Endometrial Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68099158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Risk+factors+for+the+incidence+of+endometrial+cancer+according+to+the+aggressiveness+of+disease.&rft.au=Weiss%2C+Jocelyn+M%3BSaltzman%2C+Babette+S%3BDoherty%2C+Jennifer+A%3BVoigt%2C+Lynda+F%3BChen%2C+Chu%3BBeresford%2C+Shirley+A+A%3BHill%2C+Deirdre+A%3BWeiss%2C+Noel+S&rft.aulast=Weiss&rft.aufirst=Jocelyn&rft.date=2006-07-01&rft.volume=164&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-03 N1 - Date created - 2006-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002. AN - 68070008; 16769298 AB - The objective of this study was to compare the current prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and mood, anxiety, and personality disorders among whites, blacks, Native Americans, Asians, and Hispanics in a large representative sample of the US population. Striking mental health disparities were observed in the prevalences of psychiatric disorders, especially among Native Americans. Disparities in psychiatric comorbidity differed from those associated with prevalence. Most significantly, the association between alcohol disorders and personality disorders was significantly greater among Asians relative to whites, blacks, and Native Americans, despite lower prevalences of these disorders among Asians. Taken together, the results of this study highlight the need of future studies that help unravel the risk factors underlying the disparities in both prevalence and comorbidity of psychiatric disorders observed among race-ethnic groups in the United States. JF - Comprehensive psychiatry AU - Huang, Boji AU - Grant, Bridget F AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Chou, S Patricia AU - Saha, Tulshi D AU - Goldstein, Risë B AU - Smith, Sharon M AU - Ruan, W June AU - Pickering, Roger P AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA. HuangBo@mail.nih.gov PY - 2006 SP - 252 EP - 257 VL - 47 IS - 4 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Personality Disorders -- epidemiology KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Alcoholism -- ethnology KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Mental Disorders -- ethnology KW - Substance-Related Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68070008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Race-ethnicity+and+the+prevalence+and+co-occurrence+of+Diagnostic+and+Statistical+Manual+of+Mental+Disorders%2C+Fourth+Edition%2C+alcohol+and+drug+use+disorders+and+Axis+I+and+II+disorders%3A+United+States%2C+2001+to+2002.&rft.au=Huang%2C+Boji%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BChou%2C+S+Patricia%3BSaha%2C+Tulshi+D%3BGoldstein%2C+Ris%C3%AB+B%3BSmith%2C+Sharon+M%3BRuan%2C+W+June%3BPickering%2C+Roger+P&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=47&rft.issue=4&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary on eyler and jeste: practical issues in consent capacity and mental disorders AN - 57250110; 200816580 AB - Comments on the theoretically informed suggestions offered by Lisa T. Eyler & Dilip V. Jeste (2006) for improving the informed consent process & enhancing the ability of persons with reduced mental capacity to provide informed consent. More practical matters deserving empirical consideration are addressed, including developing simpler & more effective ways of assessing consent capacity, understanding the motivations & desired outcomes of the mentally impaired for participating in research, & diagnostic factors that can make decision making about consent more difficult. References. K. Hyatt Stewart [Copyright 2006 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Shore, David AU - Shell, Pamela Hayes AU - Wishnoff, Christine Moretto AD - National Institute of Mental Health (NIMH), Bethesda, MD (a component of the NIH and the US Department of Health and Human Services HHS dshore@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 569 EP - 572 PB - John Wiley & Sons, Chichester UK VL - 24 IS - 4 SN - 0735-3936, 0735-3936 KW - Assessment KW - Comments KW - Informed consent KW - Capacity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Commentary+on+eyler+and+jeste%3A+practical+issues+in+consent+capacity+and+mental+disorders&rft.au=Shore%2C+David%3BShell%2C+Pamela+Hayes%3BWishnoff%2C+Christine+Moretto&rft.aulast=Shore&rft.aufirst=David&rft.date=2006-07-01&rft.volume=24&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.690 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Capacity; Informed consent; Comments; Assessment DO - http://dx.doi.org/10.1002/bsl.690 ER - TY - JOUR T1 - Elucidating early mechanisms of developmental psychopathology: the case of prenatal smoking and disruptive behavior AN - 36509075; 3309917 AB - There is a robust association between prenatal smoking and disruptive behavior disorders, but little is known about the emergence of such behaviors in early development. The association of prenatal smoking and hypothesized behavioral precursors to disruptive behavior in toddlers (N = 93) was tested. Exposed toddlers demonstrated atypical behavioral patterns, including (1) escalating externalizing problems from 18 to 24 months and (2) observed difficulty modulating behavior in response to social cues. Specification of exposure-related behaviors is a first step toward generating testable hypotheses about putative mechanisms of effect. While it remains unclear whether prenatal exposure plays an etiologic role in the emergence of disruptive behavior, atypical exposure-related behavioral patterns are evident in the first years of life and demonstrate developmental coherence. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Wakschlag, Lauren S AU - Leventhal, Bennett L AU - Pine, Daniel S AU - Pickett, Kate E AU - Carter, Alice S AD - University of Illinois ; National Institute of Mental Health ; University of York ; University of Massachusetts Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 893 EP - 906 VL - 77 IS - 4 SN - 0009-3920, 0009-3920 KW - Sociology KW - Empirical tests KW - Smoking KW - Behavioural psychology KW - Parents KW - Child development KW - Behavioural disorders KW - Infants KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36509075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Elucidating+early+mechanisms+of+developmental+psychopathology%3A+the+case+of+prenatal+smoking+and+disruptive+behavior&rft.au=Wakschlag%2C+Lauren+S%3BLeventhal%2C+Bennett+L%3BPine%2C+Daniel+S%3BPickett%2C+Kate+E%3BCarter%2C+Alice+S&rft.aulast=Wakschlag&rft.aufirst=Lauren&rft.date=2006-07-01&rft.volume=77&rft.issue=4&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 2197 2212 6075 3483; 6495 2212; 9184; 11755 5707 6071 1542 11325; 1540 1543 10404; 1538 6071 1542 11325; 4202 ER - TY - JOUR T1 - Maternal chronological age, prenatal and perinatal history, social support, and parenting of infants AN - 36509031; 3309916 AB - The role of maternal chronological age in prenatal and perinatal history, social support, and parenting practices of new mothers (N = 335) was examined. Primiparas of 5-month-old infants ranged in age from 13 to 42 years. Age effects were zero, linear, and nonlinear. Nonlinear age effects were significantly associated up to a certain age with little or no association afterward; by spline regression, estimated points at which the slope of the regression line changed were 25 years for prenatal and perinatal history, 31 years for social supports, and 27 years for parenting practices. Given the expanding age range of first-time parents, these findings underscore the importance of incorporating maternal age as a factor in studies of parenting and child development. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Bornstein, Marc H AU - Putnick, Diane L AU - Suwalsky, Joan T.D. AU - Gini, Motti AD - National Institutes of Health Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 875 EP - 892 VL - 77 IS - 4 SN - 0009-3920, 0009-3920 KW - Sociology KW - Age KW - Social support KW - Parenting KW - Parents KW - Child development KW - Infants KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36509031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Maternal+chronological+age%2C+prenatal+and+perinatal+history%2C+social+support%2C+and+parenting+of+infants&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BSuwalsky%2C+Joan+T.D.%3BGini%2C+Motti&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2006-07-01&rft.volume=77&rft.issue=4&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 9183; 2197 2212 6075 3483; 11938 11949 13521; 6495 2212; 9184; 646 ER - TY - JOUR T1 - Challenges of Evaluating the Cardiac Effects of Anticancer Agents AN - 21300331; 6994861 JF - Clinical Cancer Research AU - Bates, Susan E AU - Rosing, Douglas R AU - Fojo, Tito AU - Piekarz, Richard L AD - Authors' Affiliations: Medical Oncology Branch, National Cancer Institute and National Heart, Lung, and Blood Institute, Bethesda, Maryland Y1 - 2006/07/01/ PY - 2006 DA - 2006 Jul 01 SP - 3871 EP - 3874 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 13 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Antitumor agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21300331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Challenges+of+Evaluating+the+Cardiac+Effects+of+Anticancer+Agents&rft.au=Bates%2C+Susan+E%3BRosing%2C+Douglas+R%3BFojo%2C+Tito%3BPiekarz%2C+Richard+L&rft.aulast=Bates&rft.aufirst=Susan&rft.date=2006-07-01&rft.volume=12&rft.issue=13&rft.spage=3871&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Antitumor agents ER - TY - JOUR T1 - Smoking and Bladder Cancer in Spain: Effects of Tobacco Type, Timing, Environmental Tobacco Smoke, and Gender AN - 20855579; 6994536 AB - We examined the effects of dose, type of tobacco, cessation, inhalation, and environmental tobacco smoke exposure on bladder cancer risk among 1,219 patients with newly diagnosed bladder cancer and 1,271 controls recruited from 18 hospitals in Spain. We used unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the association between bladder cancer risk and various characteristics of cigarette smoking. Current smokers (men: OR, 7.4; 95% CI, 5.3-10.4; women: OR, 5.1; 95% CI, 1.6-16.4) and former smokers (men: OR, 3.8; 95% CI, 2.8-5.3; women: OR, 1.8; 95% CI, 0.5-7.2) had significantly increased risks of bladder cancer compared with nonsmokers. We observed a significant positive trend in risk with increasing duration and amount smoked. After adjustment for duration, risk was only 40% higher in smokers of black tobacco than that in smokers of blond tobacco (OR, 1.4; 95% CI, 0.98-2.0). Compared with risk in current smokers, a significant inverse trend in risk with increasing time since quitting smoking blond tobacco was observed ( greater than or equal to 20 years cessation: OR, 0.2; 95% CI, 0.1-0.9). No trend in risk with cessation of smoking black tobacco was apparent. Compared with men who inhaled into the mouth, risk increased for men who inhaled into the throat (OR, 1.7; 95% CI, 1.1-2.6) and chest (OR, 1.5; 95% CI, 1.1-2.1). Cumulative occupational exposure to environmental tobacco smoke seemed to confer increased risk among female nonsmokers but not among male nonsmokers. After eliminating the effect of cigarette smoking on bladder cancer risk in our study population, the male-to-female incidence ratio decreased from 8.2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens. (Cancer Epidemiol Biomarkers Prev 2006; 15(7):1348-54) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Samanic, Claudine AU - Kogevinas, Manolis AU - Dosemeci, Mustafa AU - Malats, Nuria AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Sala, Maria AU - Lloreta, Josep AU - Tardon, Adonina AU - Rothman, Nathaniel AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1348 EP - 1354 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 7 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts KW - Bioindicators KW - Inhalation KW - Spain KW - Carcinogens KW - Cancer KW - urinary bladder KW - Passive smoking KW - Cigarette smoking KW - Gender KW - Tobacco KW - prevention KW - Occupational exposure KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Smoking+and+Bladder+Cancer+in+Spain%3A+Effects+of+Tobacco+Type%2C+Timing%2C+Environmental+Tobacco+Smoke%2C+and+Gender&rft.au=Samanic%2C+Claudine%3BKogevinas%2C+Manolis%3BDosemeci%2C+Mustafa%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BSala%2C+Maria%3BLloreta%2C+Josep%3BTardon%2C+Adonina%3BRothman%2C+Nathaniel%3BSilverman%2C+Debra+T&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1348&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Bioindicators; urinary bladder; Passive smoking; Gender; Cigarette smoking; prevention; Tobacco; Carcinogens; Occupational exposure; Cancer; Hospitals; Spain ER - TY - JOUR T1 - Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp):A Useful Phosphotyrosyl Mimetic AN - 20639981; 7658282 AB - Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F2Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F2Pmp and a summary of approaches toward its synthesis and use. JF - Current Topics in Medicinal Chemistry AU - Burke, Terrence R AD - NCI-Frederick, P.O. Box B,Bldg. 376 Boyles St., Frederick, MD 21702-1201 USA. Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1465 EP - 1471 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 6 IS - 14 SN - 1568-0266, 1568-0266 KW - Biotechnology Research Abstracts (through 1992) KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=Design+and+Synthesis+of+Phosphonodifluoromethyl+Phenylalanine+%28F2Pmp%29%3AA+Useful+Phosphotyrosyl+Mimetic&rft.au=Burke%2C+Terrence+R&rft.aulast=Burke&rft.aufirst=Terrence&rft.date=2006-07-01&rft.volume=6&rft.issue=14&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802606777951091 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.2174/156802606777951091 ER - TY - JOUR T1 - Fluorinated Natural Products with Clinical Significance AN - 20637882; 7658286 AB - The modification of natural products in an effort to alter their biochemical capacity is a common technique utilized by synthetic and medicinal chemists. Fluorine substitution imparts unique and advantageous physiochemical properties that can be shrewdly employed to constructively alter pharmacological agents. The adornment of natural products with fluorine has proven beneficial in several examples. This overview discusses several of the most relevant fluorinated natural products under current examination. JF - Current Topics in Medicinal Chemistry AU - Thomas, Craig J AD - NIDDK, NIH, 9000 Rockville Pike, Bldg 8, Room 117, Bethesda, MD 20892. Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1529 EP - 1543 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 6 IS - 14 SN - 1568-0266, 1568-0266 KW - Biotechnology Research Abstracts (through 1992) KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=Fluorinated+Natural+Products+with+Clinical+Significance&rft.au=Thomas%2C+Craig+J&rft.aulast=Thomas&rft.aufirst=Craig&rft.date=2006-07-01&rft.volume=6&rft.issue=14&rft.spage=1529&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802606777951109 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.2174/156802606777951109 ER - TY - JOUR T1 - Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets AN - 20075970; 6994459 AB - Rats treated with the alkylating agent methylnitrosourea (MNU) develop multiple, hormonally dependent mammary tumors. Roughly 50% of the tumors have Ha-ras mutation, whereas 50% do not. The MNU-induced rat mammary tumor model was employed to examine the therapeutic efficacy of the farnesyltransferase inhibitor (FTI), R115777, and to examine the use of genomics in identifying susceptible tumors as well as identifying genes whose expression are modulated by FTI treatment. In animals bearing palpable mammary tumors (<7 mm diameter), we performed a surgical biopsy, and 3 days following the biopsy, rats were treated with R115777 (50 mg/kg body wt/day) by gavage. Tumors with Ha-ras mutations underwent profound regression, with nearly 90% showing complete regressions within 4 weeks. In contrast, the non-Ha-ras mutation-bearing tumors yielded a more variable response, although roughly half of the non-Ha-ras mutation tumors underwent significant regression. These results show that although all tumors appear to respond to the FTI inhibitor the tumors with Ha-ras mutations were exquisitely sensitive. We employed a microarray approach to define potential targets and the mechanism of action of R115777 in Ha-ras mutant or wildtype tumors following treatment with FTI. In addition, we determined whether gene expression prior to FTI treatment can be used to differentiate highly sensitive tumors (Ha-ras mutant) and tumors with variable sensitivity (Ha-ras wildtype). Untreated or FTI-treated (4 days at 50 mg/kg body wt) tumors (Ha-ras mutant or wildtype) were examined using oligonucleotide arrays. A significant number of genes were differentially expressed in control rat mammary tumors with or without an activated Ha-ras mutation, suggesting that a microarray analysis might differentiate highly sensitive and variably sensitive tumors. Most of the genes whose expressions were modulated by FTI in tumors were independent of Ha-ras status and were presumably modulated by effects on farnesylation of proteins other than Ha-ras. However, treatment of Ha-ras-mutated mammary tumors with R155777 results in preferential modulation of genes involved in ras-MAP kinase signal transduction pathway and in decreased expression of many genes involved with cell proliferation. In contrast, several classes of genes are altered in rat mammary tumors without a mutated Ha-ras, suggesting that non-ras targets are involved. Ras pathway related genes, p53, WT1 and PCNA, were preferentially modulated in Ha-ras-mutated tumors, whereas modulation of genes in the G-protein pathway, various cytochrome p450s and RB1 are involved in Ha-ras wildtype tumors. Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs. JF - Carcinogenesis AU - Yao, Ruisheng AU - Wang, Yian AU - Lu, Yan AU - Lemon, William J AU - End, David W AU - Grubbs, Clinton J AU - Lubet, Ronald A AU - You, Ming AD - Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, 660 S. Euclid Avenue, Washington University School of Medicine, St Louis, MO 63110, USA, Janssen Research Foundation, Spring House, PA 19477, USA, Chemoprevention Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA and Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1420 EP - 1431 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 7 SN - 0143-3334, 0143-3334 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Alkylating agents KW - Ras protein KW - Mammary gland KW - Animal models KW - Guanine nucleotide-binding protein KW - Biopsy KW - Tumors KW - Proliferating cell nuclear antigen KW - DNA microarrays KW - p53 protein KW - Farnesyl-diphosphate farnesyltransferase KW - Carcinogenesis KW - Farnesyltransferase KW - genomics KW - Cytochrome P450 KW - Cell proliferation KW - Adenocarcinoma KW - Mutation KW - Pharmacodynamics KW - Signal transduction KW - G 07870:Mammals KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20075970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Efficacy+of+the+farnesyltransferase+inhibitor+R115777+in+a+rat+mammary+tumor+model%3A+role+of+Ha-ras+mutations+and+use+of+microarray+analysis+in+identifying+potential+targets&rft.au=Yao%2C+Ruisheng%3BWang%2C+Yian%3BLu%2C+Yan%3BLemon%2C+William+J%3BEnd%2C+David+W%3BGrubbs%2C+Clinton+J%3BLubet%2C+Ronald+A%3BYou%2C+Ming&rft.aulast=Yao&rft.aufirst=Ruisheng&rft.date=2006-07-01&rft.volume=27&rft.issue=7&rft.spage=1420&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ras protein; Alkylating agents; Mammary gland; Animal models; Guanine nucleotide-binding protein; Biopsy; Tumors; Proliferating cell nuclear antigen; DNA microarrays; p53 protein; Farnesyl-diphosphate farnesyltransferase; Carcinogenesis; Farnesyltransferase; Cytochrome P450; genomics; Adenocarcinoma; Cell proliferation; Mutation; Pharmacodynamics; Signal transduction ER - TY - JOUR T1 - Overcoming Drug-Resistant Cancer by a Newly Developed Copper Chelate through Host-Protective Cytokine-Mediated Apoptosis AN - 19970727; 7127922 AB - PURPOSE: Previously, we have synthesized and characterized a novel Cu(II) complex, copper N-(2-hydroxy acetophenone) glycinate (CuNG). Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer using drug-resistant murine and human cancer cell lines. Experimental Design: Action of CuNG following single i.m. administration (5 mg/kg body weight) was tested in vivo on doxorubicin-resistant Ehrlich ascites carcinoma (EAC/Dox)-bearing mice and doxorubicin-resistant sarcoma 180-bearing mice. Tumor size, ascitic load, and survival rates were monitored at regular intervals. Apoptosis of cancer cells was determined by cell cycle analysis, confocal microscopy, Annexin V binding, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay ex vivo. IFN- gamma and tumor necrosis factor- alpha were assayed in the culture supernatants of in vivo and in vitro CuNG-treated splenic mononuclear cells from EAC/Dox-bearing mice and their apoptogenic effect was determined. Source of IFN- gamma and changes in number of T regulatory marker-bearing cells in the tumor site following CuNG treatment were investigated by flow cytometry. Supernatants of in vitro CuNG-treated cultures of peripheral blood mononuclear cells from different drug-insensitive cancer patients were tested for presence of the apoptogenic cytokine IFN- gamma and its involvement in induction of apoptosis of doxorubicin-resistant CEM/ADR5000 cells. RESULTS: CuNG treatment could resolve drug-resistant cancers through induction of apoptogenic cytokines, such as IFN- gamma and/or tumor necrosis factor- alpha , from splenic mononuclear cells or patient peripheral blood mononuclear cells and reduce the number of T regulatory marker-bearing cells while increase infiltration of IFN- gamma -producing T cells in the ascetic tumor site. CONCLUSION: Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers irrespective of multidrug resistance phenotype. JF - Clinical Cancer Research AU - Mookerjee, Ananda AU - Mookerjee Basu, Jayati AU - Dutta, Pranabananda AU - Majumder, Surajit AU - Bhattacharyya, Sankar AU - Biswas, Jaydip AU - Pal, Smarajit AU - Mukherjee, Pratima AU - Raha, Sanghamitra AU - Baral, Rathindra N AU - Das, Tania AU - Efferth, Thomas AU - Sa, Gourisankar AU - Roy, Shyamal AU - Choudhuri, Soumitra K AD - Authors' Affiliations: Departments of Environmental Carcinogenesis and Toxicology, Surgical Oncology and Medical Oncology, Hospital Unit, Clinical Biochemistry, Hospital Unit, In vitro Carcinogenesis and Cellular Chemotherapy, and Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 4339 EP - 4349 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 14 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - gamma -Interferon KW - Apoptosis KW - Drug resistance KW - Immunotherapy KW - Cell cycle KW - Cell culture KW - Copper KW - Metastases KW - Flow cytometry KW - Tumor cell lines KW - Peripheral blood mononuclear cells KW - Body weight KW - Lymphocytes T KW - Cytokines KW - Chelates KW - Leukocytes (mononuclear) KW - Spleen KW - Carcinoma KW - Ascites KW - Confocal microscopy KW - Sarcoma KW - Multidrug resistance KW - Tumor necrosis factor- alpha KW - Acetophenone KW - Annexin V KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19970727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Overcoming+Drug-Resistant+Cancer+by+a+Newly+Developed+Copper+Chelate+through+Host-Protective+Cytokine-Mediated+Apoptosis&rft.au=Mookerjee%2C+Ananda%3BMookerjee+Basu%2C+Jayati%3BDutta%2C+Pranabananda%3BMajumder%2C+Surajit%3BBhattacharyya%2C+Sankar%3BBiswas%2C+Jaydip%3BPal%2C+Smarajit%3BMukherjee%2C+Pratima%3BRaha%2C+Sanghamitra%3BBaral%2C+Rathindra+N%3BDas%2C+Tania%3BEfferth%2C+Thomas%3BSa%2C+Gourisankar%3BRoy%2C+Shyamal%3BChoudhuri%2C+Soumitra+K&rft.aulast=Mookerjee&rft.aufirst=Ananda&rft.date=2006-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Apoptosis; Immunotherapy; Drug resistance; Cell cycle; Cell culture; Copper; Flow cytometry; Metastases; Peripheral blood mononuclear cells; Tumor cell lines; Body weight; Lymphocytes T; Cytokines; Chelates; Leukocytes (mononuclear); Spleen; Carcinoma; Ascites; Confocal microscopy; Sarcoma; Multidrug resistance; Tumor necrosis factor- alpha; Acetophenone; Annexin V ER - TY - JOUR T1 - Lymphomas and leukemias in mice AN - 19955839; 6902715 AB - Lymphomas are among the most common tumors in many strains and stocks of mice, especially those used in safety assessment. CD-1, C57BL/6, B6C3F1 and B6; 129 mice develop 10-50% incidences of lymphomas in aging mice. Most of the tumors are B-cell lymphomas of the follicular type, arising in spleen, mesenteric lymph node and/or Peyer's patches. Lymphomas and leukemias may be induced by chemicals, retroviruses and irradiation. Genetics also play a major role in mouse lymphomagenesis and leukemogenesis. The most potent chemical carcinogens require only a single injection in young mice to induce a high incidence of lymphomas, often thymic T-cell lymphoblastic lymphomas. Several genetically engineered mouse lines have high incidences of these tumors. In 2- year carcinogenesis bioassays, increases of incidences of B-cell lymphomas (which occur naturally in controls) are indicative of less potent carcinogens. Classifications of the lymphomas and leukemias have evolved over the years. The practical WHO toxicologic pathology lymphoma and leukemia classification was developed by collaboration between the US STP, RITA, BSTP and JSTP. A more recent mouse lymphoma and leukemia classification was published by a committee of the US NCI Mouse Models of Human Cancers Consortium. This classification follows closely the more detailed human WHO classification and can be used for mouse models of lymphoma and leukemia. JF - Experimental and Toxicologic Pathology AU - Ward, Jerrold M AD - Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 3, MSC-8135, Bethesda, MD 20892-8135, USA, jw116y@nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 377 EP - 381 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 57 IS - 5-6 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Lymphoma KW - Leukaemia KW - Mice KW - Spleen KW - Carcinogenesis KW - Lymphocytes KW - Immunohistochemistry KW - Peyer's patches KW - double prime B-cell lymphoma KW - Aging KW - Thymus KW - Leukemogenesis KW - Animal models KW - Carcinogens KW - Tumors KW - Cancer KW - Lymph nodes KW - Retrovirus KW - Radiation KW - Classification KW - Genetic engineering KW - Lymphocytes T KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19955839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Lymphomas+and+leukemias+in+mice&rft.au=Valencia%2C+X%3BSimone%2C+J%3BIllei%2C+G%3BYarboro%2C+C%3BLipsky%2C+P&rft.aulast=Valencia&rft.aufirst=X&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Peyer's patches; double prime B-cell lymphoma; Thymus; Aging; Animal models; Leukemogenesis; Spleen; Tumors; Carcinogens; Lymph nodes; Cancer; Classification; Radiation; Genetic engineering; Carcinogenesis; Lymphocytes T; Retrovirus DO - http://dx.doi.org/10.1016/j.etp.2006.01.007 ER - TY - JOUR T1 - SV40 Pseudovirion gene delivery of a toxin to treat human adenocarcinomas in mice AN - 19882570; 7590157 AB - SV40 vectors packaged in vitro (pseudovirions) are an efficient delivery system for plasmids up to 17.7 kb, with or without SV40 sequences. A truncated Pseudomonas exotoxin gene (PE38) was delivered into various human cells (HeLa, KB-3-1, human lymphoblastoids, and erythroleukemia cells), in vitro using pseudovirions. The number of viable cells was reduced significantly in the PE38-transduced cells. Human KB adenocarcinomas growing in mice were treated with intratumoral injection of PE38 packaged in vitro, and tumor size decreased significantly. Intraperitoneal treatments were as effective in reducing tumor size as intratumoral treatments. To check the viability of mock- or PE38-treated mice, every 4 days they were weighed, their blood was tested, and various tissues were screened for pathology. All parameters showed that the in vitro-packaged vectors, injected into tumors or intraperitoneally, caused no abnormalities in mice. The combined treatment of doxorubicin with in vitro-packaged PE3 reduced tumor size slightly more than each of the treatments separately. However, the combined treatment did not cause the weight loss seen with doxorubicin alone. These results indicate that SV40 in vitro packaging is an effective system for cancer gene delivery using two different routes of injection and in combination with chemotherapy. JF - Cancer Gene Therapy AU - Kimchi-Sarfaty, C AU - Vieira, W D AU - Dodds, D AU - Sherman, A AU - Kreitman, R J AU - Shinar, S AU - Gottesman, M M AD - Laboratory of Cell Biology, National Cancer Institute, NIH, 37 Convent Drive, Room 2108, Bethesda, MD 20892-4256, USA, mgottesman@nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 648 EP - 657 VL - 13 IS - 7 SN - 0929-1903, 0929-1903 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Chemotherapy KW - Pseudomonas KW - Tumors KW - Plasmids KW - Doxorubicin KW - Toxins KW - Exotoxins KW - Cancer KW - Blood KW - Gene transfer KW - Erythroleukemia KW - Simian virus 40 KW - Adenocarcinoma KW - J 02310:Genetics & Taxonomy KW - W 30905:Medical Applications KW - X 24310:Pharmaceuticals KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19882570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Conference+on+Bioengineering&rft.atitle=Strategies+for+Automated+Extraction+of+Young%27s+Moduli+of+Soft+Materials+from+Afm+Force+Curves%3A+Application+to+Cartilage&rft.au=Lin%2C+David%3BDimitriadis%2C+Emilios%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Conference+on+Bioengineering&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; Gene therapy; Erythroleukemia; Gene transfer; Chemotherapy; Tumors; Plasmids; Adenocarcinoma; Cancer; Exotoxins; Toxins; Doxorubicin; Simian virus 40; Pseudomonas DO - http://dx.doi.org/10.1038/sj.cgt.7700943 ER - TY - JOUR T1 - Sir Richard Doll on Chance and Genetic Susceptibility in Carcinogenesis, or, Why Not All Smokers Get Lung Cancer AN - 19848081; 6994550 JF - Cancer Epidemiology, Biomarkers & Prevention AU - Schatzkin, Arthur AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1420 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 7 SN - 1055-9965, 1055-9965 KW - Toxicology Abstracts KW - Carcinogenesis KW - Lung cancer KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Sir+Richard+Doll+on+Chance+and+Genetic+Susceptibility+in+Carcinogenesis%2C+or%2C+Why+Not+All+Smokers+Get+Lung+Cancer&rft.au=Schatzkin%2C+Arthur&rft.aulast=Schatzkin&rft.aufirst=Arthur&rft.date=2006-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Conference+on+Bioengineering&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Carcinogenesis; Lung cancer ER - TY - JOUR T1 - Screen-less expanded bed column: new approach for the recovery and purification of a malaria transmission blocking vaccine candidate from Pichia pastoris AN - 19508601; 7200820 AB - An experimental malaria transmission blocking vaccine antigen, Pfs25H, expressed and secreted from Pichia pastoris was recovered and purified using a screenless expanded bed column equipped with a rotating fluid distribution system. This column was able to accommodate feed stock, containing 30% biomass, at a flow rate of 300-400 cm/h without affecting column stability. This capability is three times higher than the capability of the expanded bed column currently in use, which is equipped with a perforated plate fluid distribution system; this design could accommodate biomass concentrations of only up to 10%. The screen-less design did not affect the binding capacity, purification level or process yield and, therefore, shorten the process. Purified Pfs25H of 6.4 g were recovered from 37 l of Pichia pastoris culture in one step. JF - Biotechnology Letters AU - Trinh, Loc AU - Phue, Je-Nie AU - Jaluria, Pratik AU - Tsai, Chiawei W AU - Narum, David L AU - Shiloach, Joseph AD - Biotechnology Unit, NIDDK, NIH Bldg 14A, Room 173, Bethesda, MD, 20892, USA, yossi@nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 951 EP - 958 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 28 IS - 13 SN - 0141-5492, 0141-5492 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Malaria KW - Vaccines KW - Pichia pastoris KW - Biomass KW - K 03350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19508601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+American+Congress+of+Epidemiology&rft.atitle=Is+what+you+Eat+Important%3F&rft.au=Chew%2C+Emily&rft.aulast=Chew&rft.aufirst=Emily&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+American+Congress+of+Epidemiology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Malaria; Vaccines; Biomass; Pichia pastoris DO - http://dx.doi.org/10.1007/s10529-006-9029-3 ER - TY - JOUR T1 - Proteomics: A New Diagnostic Frontier AN - 19458357; 6994898 AB - BACKGROUND: Analysis of proteins has been an integral part of the field of clinical chemistry for decades. Recent advances in technology and complete identification of the human genome sequence have opened up new opportunities for analysis of proteins for clinical diagnostic purposes. METHODS: Content of a recent conference of proteomics is summarized. RESULTS: New analytical methods allow the simultaneous analysis of a large number of proteins in biological fluids such as serum and plasma, offering partial views of the complete set of proteins or proteome. Plasma presents many analytical challenges, such as the complexity of components, predominance of a few major components, and the large concentration range of components, but the number of proteins that can be detected in plasma has expanded dramatically from hundreds to thousands. At the same time, there is increased capability to detect structural variations of proteins. Recent studies also identified the presence of complex sets of small protein fragments in plasma. This set of protein fragments, the fragmentome or peptidome, is potentially a rich source of information about physiologic and disease processes. CONCLUSIONS: Advances in proteomics offer great promise for the discovery of markers that might serve as the basis for new clinical laboratory tests. There are many challenges, however, in the translation of newly discovered markers into clinical laboratory tests. JF - Clinical Chemistry AU - Hortin, Glen L AU - Jortani, Saeed A AU - Ritchie, James CJr AU - Valdes, Roland Jr AU - Chan, Daniel W AD - Department of Laboratory Medicine, Intramural research program of the NIH Clinical Center, National Institutes of Health, Bethesda, MD. Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY. Department of Pathology, Emory University, Atlanta, GA. Department of Pathology, Johns Hopkins University, Baltimore, MD Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1218 EP - 1222 PB - American Association for Clinical Chemistry, Inc. VL - 52 IS - 7 SN - 0009-9147, 0009-9147 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Translation KW - Nucleotide sequence KW - proteomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Proteomics%3A+A+New+Diagnostic+Frontier&rft.au=Hortin%2C+Glen+L%3BJortani%2C+Saeed+A%3BRitchie%2C+James+CJr%3BValdes%2C+Roland+Jr%3BChan%2C+Daniel+W&rft.aulast=Hortin&rft.aufirst=Glen&rft.date=2006-07-01&rft.volume=52&rft.issue=7&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Translation; Nucleotide sequence; proteomics ER - TY - JOUR T1 - A Multiplex Tissue Immunoblotting Assay for Proteomic Profiling: A Pilot Study of the Normal to Tumor Transition of Esophageal Squamous Cell Carcinoma AN - 19456417; 6994545 AB - Esophageal cancer remains a highly lethal malignancy for which the genetic and proteomic events are poorly understood. Studies have reported dysregulated proteins in esophageal carcinoma; however, the magnitude of these changes remains largely uncharacterized. Little is known about alterations early in the neoplastic pathway. Using multiplex tissue immunoblotting, we quantified the expression of seven proteins in esophageal carcinogenesis. Regions of normal, dysplasia, and invasive carcinoma of the squamous esophagus in six patients were characterized. Pan-cytokeratin (CK) was essentially unchanged across the transition (0.96 in dysplasia and 0.69 in tumor). Expression levels of annexin 1, CK-4, and CK-14 were all decreased in dysplasia and tumor compared with normal (reference, 1.00): annexin 1, 0.30 in dysplasia and 0.15 in tumor; CK-4, 0.20 in dysplasia and 0.16 in tumor; and CK-14, 0.54 in dysplasia and 0.40 in tumor. Expression of two proteins was increased in dysplasia and tumor versus normal: cyclooxygenase-2, 1.35 in dysplasia and 2.32 in tumor and p53, 1.29 in dysplasia and 2.37 in tumor. Secreted protein, acidic and rich in cysteine, which is expressed in the adjacent stroma, was 1.56-fold higher in stroma underlying dysplasia and 6.20-fold increased in dysplastic stroma surrounding invasive tumor. These findings suggest that changes in protein expression can be detected during the transition to dysplasia and may be useful biomarkers. (Cancer Epidemiol Biomarkers Prev 2006; 15(7):1403-8) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chung, Joon-Yong AU - Braunschweig, Till AU - Hu, Nan AU - Roth, Mark AU - Traicoff, June L AU - Wang, Quan-Hong AU - Knezevic, Vladimir AU - Taylor, Philip R AU - Hewitt, Stephen M AD - Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research and Cancer Prevention Studies Branch, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1403 EP - 1408 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 7 SN - 1055-9965, 1055-9965 KW - Biotechnology and Bioengineering Abstracts KW - Cyclooxygenase-2 KW - Stroma KW - Esophagus KW - Immunoblotting KW - Invasiveness KW - Dysplasia KW - esophageal carcinoma KW - squamous cell carcinoma KW - Tumors KW - biomarkers KW - p53 protein KW - Malignancy KW - Annexins KW - Cysteine KW - Carcinogenesis KW - proteomics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=A+Multiplex+Tissue+Immunoblotting+Assay+for+Proteomic+Profiling%3A+A+Pilot+Study+of+the+Normal+to+Tumor+Transition+of+Esophageal+Squamous+Cell+Carcinoma&rft.au=Chung%2C+Joon-Yong%3BBraunschweig%2C+Till%3BHu%2C+Nan%3BRoth%2C+Mark%3BTraicoff%2C+June+L%3BWang%2C+Quan-Hong%3BKnezevic%2C+Vladimir%3BTaylor%2C+Philip+R%3BHewitt%2C+Stephen+M&rft.aulast=Chung&rft.aufirst=Joon-Yong&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dysplasia; Tumors; Esophagus; Stroma; Annexins; biomarkers; Invasiveness; Immunoblotting; proteomics; Malignancy; p53 protein; Carcinogenesis; Cysteine; Cyclooxygenase-2; squamous cell carcinoma; esophageal carcinoma ER - TY - JOUR T1 - Fabrication and characterization of six electrospun poly( alpha -hydroxy ester)- based fibrous scaffolds for tissue engineering applications AN - 19439289; 6868568 AB - The most common synthetic biodegradable polymers being investigated for tissue engineering applications are FDA approved, clinically used poly( alpha - hydroxy esters). To better assess the applicability of the electrospinning technology for scaffold fabrication, six commonly used poly( alpha -hydroxy esters) were used to prepare electrospun fibrous scaffolds, and their physical and biological properties were also characterized. Our results suggest that specific, optimized fabrication parameters are required for each polymer to produce scaffolds that consist of uniform structures morphologically similar to native extracellular matrix. Scanning electron microscopy (SEM) revealed a highly porous, three-dimensional structure for all scaffolds, with average fiber diameter ranging from 300 nm to 1.5 mu m, depending on the polymer type used. The poly(glycolic acid) (PGA) and poly(d,l-lactic-co-glycolic acid 50:50) (PLGA5050) fibrous structures were mechanically stiffest, whereas the poly(l- lactic acid) (PLLA) and poly( epsilon -caprolactone) (PCL) scaffolds were most compliant. Upon incubation in physiological solution, severe structural destruction due to polymer degradation was found in the PGA, poly(d,l-lactic acid) (PDLLA), PLGA5050, and poly(d,l-lactic-co-glycolic acid 85:15) (PLGA8515) fibrous scaffolds, whereas PLLA and PCL fibrous scaffolds maintained a robust scaffold structure during the same time period, based on macroscopic and SEM observations. In addition, PLLA scaffolds supported the highest rate of proliferation of seeded cells (chondrocytes and mesenchymal stem cells) than other polymeric scaffolds. Our findings showed that PLLA and PCL based fibrous scaffolds exhibited the most optimal structural integrity and supported desirable cellular response in culture, suggesting that such scaffolds may be promising candidate biomaterials for tissue engineering applications. JF - Acta Biomaterialia AU - Li, Wan-Ju AU - Cooper, James A AU - Mauck, Robert L AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Room 1523, Bldg 50, MSC 8022, Department of Health and Human Services, Bethesda, MD 20892, United States, tuanr@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 377 EP - 385 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 2 IS - 4 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Scanning electron microscopy KW - Chondrocytes KW - polylactic acid KW - Cell culture KW - Esters KW - Tissue engineering KW - scaffolds KW - Fibers KW - Stem cells KW - Extracellular matrix KW - Lactic acid KW - Biomaterials KW - Cell proliferation KW - Mesenchyme KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Fabrication+and+characterization+of+six+electrospun+poly%28+alpha+-hydroxy+ester%29-+based+fibrous+scaffolds+for+tissue+engineering+applications&rft.au=Li%2C+Wan-Ju%3BCooper%2C+James+A%3BMauck%2C+Robert+L%3BTuan%2C+Rocky+S&rft.aulast=Li&rft.aufirst=Wan-Ju&rft.date=2006-07-01&rft.volume=2&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2006.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - scaffolds; polylactic acid; Tissue engineering; Esters; Stem cells; Chondrocytes; Biomaterials; Mesenchyme; Cell culture; Cell proliferation; Scanning electron microscopy; Extracellular matrix; Fibers; Lactic acid DO - http://dx.doi.org/10.1016/j.actbio.2006.02.005 ER - TY - JOUR T1 - Linking the human cytogenetic map with nucleotide sequence: the CCAP clone set AN - 17699947; 7602130 AB - We present the completed dataset and clone repository of the Cancer Chromosome Aberration Project (CCAP), an initiative developed and funded through the intramural program of the U.S. National Cancer Institute, to provide seamless linkage of human cytogenetic markers with the primary nucleotide sequence of the human genome. Spaced at 1-2 Mb intervals across the human genome, 1,339 bacterial artificial chromosome (BAC) clones have been localized to chromosomal bands through high-resolution fluorescence in situ hybridization (FISH) mapping. Of these clones, 99.8% can be positioned on the primary human genome sequence and 95% are placed at or close to their precise nucleotide starts and stops. This dataset can be studied and manipulated within generally available public Web sites. The clones are available from a commercial repository. The CCAP BAC clone set provides anchors for the interrogation of gene and sequence involvement in oncogenic and developmental disorders when the starting point is the recognition of a structural, numerical, or interstitial chromosomal aberration. This dataset also provides a current view of the quality and coherence of the available genome sequence and insight into the nucleotide and three-dimensional structures that manifest as Giemsa light and dark chromosomal banding patterns. JF - Cancer Genetics and Cytogenetics AU - Jang, Wonhee AU - Yonescu, Raluca AU - Knutsen, Turid AU - Brown, Theresa AU - Reppert, Tricia AU - Sirotkin, Karl AU - Schuler, Gregory D AU - Ried, Thomas AU - Kirsch, Ilan R AD - National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, RiedT@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 89 EP - 97 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 168 IS - 2 SN - 0165-4608, 0165-4608 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Bacterial artificial chromosomes KW - Nucleotide sequence KW - Chromosome aberrations KW - Cancer KW - Fluorescence in situ hybridization KW - Gene mapping KW - Light effects KW - G 07880:Human Genetics KW - N 14815:Nucleotide Sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17699947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Public+Health+Messages+and+Dietary+Fat%3A+Making+Sense+of+the+Women%27s+Health+Initiative+Findings&rft.au=Milner%2C+J&rft.aulast=Milner&rft.aufirst=J&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bacterial artificial chromosomes; Genomes; Nucleotide sequence; Chromosome aberrations; Cancer; Light effects; Gene mapping; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1016/j.cancergencyto.2006.01.001 ER - TY - JOUR T1 - Functional Heterogeneity of RpoS in Stress Tolerance of Enterohemorrhagic Escherichia coli Strains AN - 17264482; 6992642 AB - The stationary-phase sigma factor (RpoS) regulates many cellular responses to environmental stress conditions such as heat, acid, and alkali shocks. On the other hand, mutations at the rpoS locus have frequently been detected among pathogenic as well as commensal strains of Escherichia coli. The objective of this study was to perform a functional analysis of the RpoS-mediated stress responses of enterohemorrhagic E. coli strains from food-borne outbreaks. E. coli strains belonging to serotypes O157:H7, O111:H11, and O26:H11 exhibited polymorphisms for two phenotypes widely used to monitor rpoS mutations, heat tolerance and glycogen synthesis, as well as for two others, alkali tolerance and adherence to Caco-2 cells. However, these strains synthesized the oxidative acid resistance system through an rpoS-dependent pathway. During the transition from mildly acidic growth conditions (pH 5.5) to alkaline stress (pH 10.2), cell survival was dependent on rpoS functionality. Some strains were able to overcome negative regulation by RpoS and induced higher {szligbeta}-galactosidase activity without compromising their acid resistance. There were no major differences in the DNA sequences in the rpoS coding regions among the tested strains. The heterogeneity of rpoS-dependent phenotypes observed for stress-related phenotypes was also evident in the Caco-2 cell adherence assay. Wild-type O157:H7 strains with native rpoS were less adherent than rpoS-complemented counterpart strains, suggesting that rpoS functionality is needed. These results show that some pathogenic E. coli strains can maintain their acid tolerance capability while compromising other RpoS-dependent stress responses. Such adaptation processes may have significant impact on a pathogen's survival in food processing environments, as well in the host's stomach and intestine. JF - Applied and Environmental Microbiology AU - Bhagwat, Arvind A AU - Tan, Jasmine AU - Sharma, Manan AU - Kothary, Mahendra AU - Low, Sharon AU - Tall, Ben D AU - Bhagwat, Medha AD - Produce Quality and Safety Laboratory. Food Technology and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, Maryland 20705-2350. Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland 20708. National Center for Biotechnology Information, Bldg. 38A, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 4978 EP - 4986 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 7 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Food processing KW - Serotypes KW - Adaptations KW - Growth conditions KW - Nucleotide sequence KW - Commensals KW - Heat tolerance KW - Glycogen KW - Shock KW - Heat KW - Escherichia coli KW - Intestine KW - Environmental stress KW - Sigma factor KW - Alkalis KW - Mutation KW - pH effects KW - Stomach KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Functional+Heterogeneity+of+RpoS+in+Stress+Tolerance+of+Enterohemorrhagic+Escherichia+coli+Strains&rft.au=Bhagwat%2C+Arvind+A%3BTan%2C+Jasmine%3BSharma%2C+Manan%3BKothary%2C+Mahendra%3BLow%2C+Sharon%3BTall%2C+Ben+D%3BBhagwat%2C+Medha&rft.aulast=Bhagwat&rft.aufirst=Arvind&rft.date=2006-07-01&rft.volume=72&rft.issue=7&rft.spage=4978&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Food processing; Cell survival; Adaptations; Serotypes; Growth conditions; Nucleotide sequence; Heat tolerance; Commensals; Glycogen; Shock; Heat; Intestine; Environmental stress; Alkalis; Sigma factor; pH effects; Mutation; Stomach; Escherichia coli ER - TY - JOUR T1 - Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists AN - 17179527; 6839758 AB - A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro. JF - Bioorganic and Medicinal Chemistry Letters AU - Kulkarni, Santosh S AU - Nightingale, Barbara AU - Dersch, Christina M AU - Rothman, Richard B AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, anewman@intra.nida.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 3371 EP - 3375 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 13 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Metabotropic glutamate receptor subtype 5 KW - mGluR5 KW - Noncompetitive antagonists KW - Glutamic acid receptors (metabotropic) KW - amides KW - W 30965:Miscellaneous, Reviews KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17179527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Design+and+synthesis+of+noncompetitive+metabotropic+glutamate+receptor+subtype+5+antagonists&rft.au=Kulkarni%2C+Santosh+S%3BNightingale%2C+Barbara%3BDersch%2C+Christina+M%3BRothman%2C+Richard+B%3BNewman%2C+Amy+Hauck&rft.aulast=Kulkarni&rft.aufirst=Santosh&rft.date=2006-07-01&rft.volume=16&rft.issue=13&rft.spage=3371&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.04.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Glutamic acid receptors (metabotropic); amides DO - http://dx.doi.org/10.1016/j.bmcl.2006.04.032 ER - TY - JOUR T1 - Molecular cloning and characterisation of peroxinectin, a cell adhesion molecule, from the giant freshwater prawn Macrobrachium rosenbergii AN - 17179437; 6842967 AB - Expression of peroxinectin cDNA was determined from haemocytes of giant freshwater prawn Macrobrachium rosenbergii using oligonucleotide primers and reverse transcription polymerase chain reaction (RT-PCR) based on the peroxinectin sequence of white shrimp Litopenaeus vannamei, tiger shrimp Penaeus monodon, and freshwater crayfish Pacifastacus leniusculus. The peroxinectin of M. rosenbergii was constitutively expressed. Analysis of the nucleotide sequence revealed that the cDNA clone has an open reading frame of 2403bp encoding a protein of 801 amino acids including a 20 amino acid signal peptide. The calculated molecular mass of the mature protein (781 amino acids) was 88.7kDa with an estimated pI of 6.8. A putative peroxidase domain and a putative integrin-binding motif, KGD (Lys-Gly-Asp) were observed in prawn peroxinectin at the C-terminal. Sequence comparison showed that peroxinectin deduced amino acid of M. rosenbergii had an overall similarity of 62%, 64%, and 66% to that of P. leniusculus, P. monodon, and L. vannamei, respectively. Quantitative real-time PCR analysis showed that peroxinectin transcript in haemocyte of M. rosenbergii decreased significantly after 3, 6 and 12h injection with Lactococcus garvieae. JF - Fish & Shellfish Immunology AU - Hsu, P I AU - Liu, CH AU - Tseng, D Y AU - Lee, P P AU - Cheng, W AD - National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu Hsiang, Pingtung 91201, Taiwan, winton@mail.npust.edu.tw Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1 EP - 10 PB - Elsevier Ltd VL - 21 IS - 1 SN - 1050-4648, 1050-4648 KW - Crayfishes KW - Giant river prawn KW - Giant tiger prawn KW - Signal crayfish KW - Whiteleg shrimp KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts; Immunology Abstracts KW - Peroxidase KW - Nucleotide sequence KW - Signal peptides KW - Cambaridae KW - Freshwater KW - Oligonucleotides KW - Reverse transcription KW - Gene expression KW - Genetics KW - Pacifastacus leniusculus KW - Molecular weight KW - Freshwater crustaceans KW - Hemocytes KW - Litopenaeus vannamei KW - Polymerase chain reaction KW - Invertebrate immunity KW - Macrobrachium rosenbergii KW - Clones KW - Penaeus monodon KW - Amino acids KW - Freshwater environments KW - Immunology KW - Transcription KW - Adhesion KW - Lactococcus garvieae KW - Primers KW - Peptides KW - Cell adhesion molecules KW - Open reading frames KW - Amino acid sequence KW - J 02410:Animal Diseases KW - Q1 08286:Physiology, biochemistry, biophysics KW - Q4 27200:Shellfish and other aquatic animals (excl. fish) KW - F 06406:Invertebrate Immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17179437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fish+%26+Shellfish+Immunology&rft.atitle=Molecular+cloning+and+characterisation+of+peroxinectin%2C+a+cell+adhesion+molecule%2C+from+the+giant+freshwater+prawn+Macrobrachium+rosenbergii&rft.au=Hsu%2C+P+I%3BLiu%2C+CH%3BTseng%2C+D+Y%3BLee%2C+P+P%3BCheng%2C+W&rft.aulast=Hsu&rft.aufirst=P&rft.date=2006-07-01&rft.volume=21&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Fish+%26+Shellfish+Immunology&rft.issn=10504648&rft_id=info:doi/10.1016%2Fj.fsi.2005.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clones; Gene expression; Genetics; Immunology; Molecular weight; Nucleotide sequence; Freshwater crustaceans; Transcription; Peptides; Adhesion; Amino acid sequence; Amino acids; Freshwater environments; Peroxidase; Signal peptides; Oligonucleotides; Reverse transcription; Hemocytes; Polymerase chain reaction; Primers; Invertebrate immunity; Open reading frames; Cell adhesion molecules; Penaeus monodon; Pacifastacus leniusculus; Lactococcus garvieae; Cambaridae; Litopenaeus vannamei; Macrobrachium rosenbergii; Freshwater DO - http://dx.doi.org/10.1016/j.fsi.2005.08.010 ER - TY - JOUR T1 - Action and reaction: the arthropod-borne flaviviruses and host interferon responses AN - 1017958159; 16580094 AB - The arthropod-borne flaviviruses include tick- and mosquito-borne viruses that are causes of globally significant emerging diseases. These single-stranded RNA viruses are exquisitely sensitive to the antiviral effects of host interferons. However, both the tick- and mosquito-borne flaviviruses are capable of modulating the interferon response. Despite the high degree of similarity among members of the flavivirus genus, the mechanisms employed by individual viruses to modulate interferon responses differ. This review considers the arthropod-borne flaviviruses and the host interferon response as a pair of forces, the action and the reaction. The interaction of these two forces has led to a complex relationship between virus and host. An increased understanding of these interactions will likely facilitate the rational design of novel vaccines and therapeutics. JF - Future Virology AU - Best, Sonja M AU - Mitzel, Dana N AU - Bloom, Marshall E AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, 903 South Fourth Street, Hamilton, MT 59840, USA., sbest@niaid.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 447 EP - 459 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 1 IS - 4 SN - 1746-0794, 1746-0794 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts KW - flavivirus KW - inhibition KW - innate immunity KW - interferon KW - interferon regulatory factor-3 KW - Janus kinase-signal transducer and activator of transcription KW - mosquito KW - tick KW - Virology KW - Viruses KW - Disease control KW - RNA viruses KW - Hosts KW - Flavivirus KW - Public health KW - Interferon KW - alpha -Interferon KW - Vaccines KW - Aquatic insects KW - V 22410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017958159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+Virology&rft.atitle=Action+and+reaction%3A+the+arthropod-borne+flaviviruses+and+host+interferon+responses&rft.au=Best%2C+Sonja+M%3BMitzel%2C+Dana+N%3BBloom%2C+Marshall+E&rft.aulast=Best&rft.aufirst=Sonja&rft.date=2006-07-01&rft.volume=1&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Future+Virology&rft.issn=17460794&rft_id=info:doi/10.2217%2F17460794.1.4.447 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 84 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Virology; Viruses; Disease control; Vaccines; Hosts; Aquatic insects; Public health; Interferon; alpha -Interferon; RNA viruses; Flavivirus DO - http://dx.doi.org/10.2217/17460794.1.4.447 ER - TY - JOUR T1 - CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system. AN - 68567209; 16632469 AB - Nerve growth factor (NGF) synthesis in the rat cerebral cortex is induced by the beta2-adrenergic receptor agonist clenbuterol (CLE). Because NGF is a crucial neurotrophic factor for basal forebrain cholinergic neurons, defining the mechanisms that regulate its transcription is important for developing therapeutic strategies to treat pathologies of these neurons. We previously showed that the transcription factor CCAAT/enhancer-binding protein delta (C/EBPdelta) contributes to NGF gene regulation. Here we have further defined the function of C/EBPdelta and identified a role for cAMP response element-binding protein (CREB) in NGF transcription. Inhibition of protein kinase A in C6-2B glioma cells suppressed CLE induction of an NGF promoter-reporter construct, whereas overexpression of protein kinase A increased NGF promoter activity, particularly in combination with C/EBPdelta. A CRE-like site that binds CREB was identified in the proximal NGF promoter, and C/EBPdelta and CREB were found to associate with the NGF promoter in vivo. Deletion of the CRE and/or C/EBP sites reduced CLE responsiveness of the promoter. In addition, ectopic expression of C/EBPdelta in combination with CLE treatment increased endogenous NGF mRNA levels in C6-2B cells. C/EBPdelta null mice showed complete loss of NGF induction in the cerebral cortex following CLE treatment, demonstrating a critical role for C/EBPdelta in regulating beta2-adrenergic receptor-mediated NGF expression in vivo. Thus, our findings demonstrate a critical role for C/EBPdelta in regional expression of NGF in the brain and implicate CREB in CLE-induced NGF gene transcription. JF - The Journal of biological chemistry AU - McCauslin, Christine Seitz AU - Heath, Victoria AU - Colangelo, Anna Maria AU - Malik, Radek AU - Lee, Sook AU - Mallei, Alessandra AU - Mocchetti, Italo AU - Johnson, Peter F AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2006/06/30/ PY - 2006 DA - 2006 Jun 30 SP - 17681 EP - 17688 VL - 281 IS - 26 SN - 0021-9258, 0021-9258 KW - Adrenergic beta-Agonists KW - 0 KW - CCAAT-Enhancer-Binding Protein-beta KW - RNA, Messenger KW - Viral Proteins KW - CCAAT-Enhancer-Binding Protein-delta KW - 142662-43-9 KW - Nerve Growth Factor KW - 9061-61-4 KW - CREB-Binding Protein KW - EC 2.3.1.48 KW - Crebbp protein, mouse KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Clenbuterol KW - XTZ6AXU7KN KW - Index Medicus KW - Viral Proteins -- genetics KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Promoter Regions, Genetic -- physiology KW - Animals KW - Clenbuterol -- pharmacology KW - Integrases -- genetics KW - Mice KW - CCAAT-Enhancer-Binding Protein-beta -- genetics KW - Mice, Knockout KW - Rats KW - Mutagenesis, Site-Directed KW - Adrenergic beta-Agonists -- pharmacology KW - Integrases -- metabolism KW - Gene Expression Regulation -- physiology KW - RNA, Messenger -- metabolism KW - CCAAT-Enhancer-Binding Protein-beta -- metabolism KW - Viral Proteins -- metabolism KW - Gene Expression Regulation -- drug effects KW - Glioma KW - CREB-Binding Protein -- metabolism KW - CCAAT-Enhancer-Binding Protein-delta -- metabolism KW - Transcriptional Activation -- physiology KW - Transcriptional Activation -- drug effects KW - CCAAT-Enhancer-Binding Protein-delta -- genetics KW - Nerve Growth Factor -- genetics KW - CREB-Binding Protein -- genetics KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68567209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=CAAT%2Fenhancer-binding+protein+delta+and+cAMP-response+element-binding+protein+mediate+inducible+expression+of+the+nerve+growth+factor+gene+in+the+central+nervous+system.&rft.au=McCauslin%2C+Christine+Seitz%3BHeath%2C+Victoria%3BColangelo%2C+Anna+Maria%3BMalik%2C+Radek%3BLee%2C+Sook%3BMallei%2C+Alessandra%3BMocchetti%2C+Italo%3BJohnson%2C+Peter+F&rft.aulast=McCauslin&rft.aufirst=Christine&rft.date=2006-06-30&rft.volume=281&rft.issue=26&rft.spage=17681&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNAse treatment following thawing of Cryopreserved PBMC is a procedure suitable for lymphocyte functional studies AN - 19310075; 7043094 AB - Testing freshly isolated PBMC is not practical for immune monitoring analysis in large clinical trials or natural history studies. Thus, cryopreserved PBMC represent a more practical alternative. However, cell clumping is a common problem following thawing of PBMC isolated from blood that was previously transported and stored. Cell clumping leads to loss of cells, and could affect cell function and/or phenotype. The development and validation of procedures that prevent cell clumping and preserve cell function and surface marker expression levels are necessary to allow evaluation of immune function and phenotype in cryopreserved samples from clinical studies. The incorporation of a DNAse treatment step in the standard thawing procedure efficiently avoided clump formation, and did not result in detectable changes in cell viability, expression of standard leukocyte surface markers or two key parameters of immune function, proliferation and cytokine induction in response to a variety of common stimuli. Therefore, this procedure seems suitable for standard immunologic assays. JF - Journal of Immunological Methods AU - Garcia-Pineres, A J AU - Hildesheim, A AU - Williams, M AU - Trivett, M AU - Strobl, S AU - Pinto, LA AD - SAIC-Frederick, Inc., NCI-Frederick, Frederick MD, USA, lpinto@ncifcrf.gov Y1 - 2006/06/30/ PY - 2006 DA - 2006 Jun 30 SP - 209 EP - 213 PB - Elsevier B.V. VL - 313 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Peripheral blood mononuclear cells KW - Leukocytes KW - Cytokines KW - Deoxyribonuclease KW - Lymphocytes KW - Clinical trials KW - Cryopreservation KW - Surface markers KW - Thawing KW - F 06706:Cell-related methods KW - W3 33225:Cryopreservation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19310075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=DNAse+treatment+following+thawing+of+Cryopreserved+PBMC+is+a+procedure+suitable+for+lymphocyte+functional+studies&rft.au=Garcia-Pineres%2C+A+J%3BHildesheim%2C+A%3BWilliams%2C+M%3BTrivett%2C+M%3BStrobl%2C+S%3BPinto%2C+LA&rft.aulast=Garcia-Pineres&rft.aufirst=A&rft.date=2006-06-30&rft.volume=313&rft.issue=1-2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Peripheral blood mononuclear cells; Leukocytes; Cytokines; Deoxyribonuclease; Lymphocytes; Cryopreservation; Clinical trials; Surface markers; Thawing DO - http://dx.doi.org/10.1016/j.jim.2006.04.004 ER - TY - JOUR T1 - Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. AN - 68106043; 16789744 AB - The substituted thieno[2,3-d]pyrimidine 3 (Org 41841), a partial agonist for the luteinizing hormone/choriogonadotropin receptor (LHCGR) and the closely related thyroid-stimulating hormone receptor (TSHR), was fundamentally altered, and the resulting analogues were analyzed for their potencies, efficacies, and specificities at LHCGR and TSHR. Chemical modification of the parent compound combined with prior mutagenesis of TSHR provided compelling experimental evidence in support of computational models of 3 binding to TSHR and LHCGR within their transmembrane cores. Biochemical analysis of a specific modification to the chemical structure of 3 provides additional evidence of a H-bond between the ligand and a glutamate residue in transmembrane helix 3, which is conserved in both receptors. Several key interactions were surveyed to determine their respective biochemical roles in terms of both van der Waals dimensions and hydrogen bond capacity and the respective relationship to biological activity. JF - Journal of medicinal chemistry AU - Moore, Susanna AU - Jaeschke, Holger AU - Kleinau, Gunnar AU - Neumann, Susanne AU - Costanzi, Stefano AU - Jiang, Jian-kang AU - Childress, John AU - Raaka, Bruce M AU - Colson, Anny AU - Paschke, Ralf AU - Krause, Gerd AU - Thomas, Craig J AU - Gershengorn, Marvin C AD - Chemical Biology Core Facility, Clinical Endocrinology Branch, and Computational Chemistry Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 SP - 3888 EP - 3896 VL - 49 IS - 13 SN - 0022-2623, 0022-2623 KW - Chorionic Gonadotropin KW - 0 KW - Ligands KW - Org 41841 KW - Pyrimidines KW - Receptors, Thyrotropin KW - Thiophenes KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - Hydrogen Bonding KW - Structure-Activity Relationship KW - Binding Sites KW - Pyrimidines -- chemistry KW - Receptors, Thyrotropin -- chemistry KW - Luteinizing Hormone -- chemistry KW - Thiophenes -- chemistry KW - Pyrimidines -- chemical synthesis KW - Models, Molecular KW - Chorionic Gonadotropin -- chemistry KW - Thiophenes -- chemical synthesis KW - Receptors, Thyrotropin -- agonists KW - Luteinizing Hormone -- agonists KW - Chorionic Gonadotropin -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Evaluation+of+small-molecule+modulators+of+the+luteinizing+hormone%2Fchoriogonadotropin+and+thyroid+stimulating+hormone+receptors%3A+structure-activity+relationships+and+selective+binding+patterns.&rft.au=Moore%2C+Susanna%3BJaeschke%2C+Holger%3BKleinau%2C+Gunnar%3BNeumann%2C+Susanne%3BCostanzi%2C+Stefano%3BJiang%2C+Jian-kang%3BChildress%2C+John%3BRaaka%2C+Bruce+M%3BColson%2C+Anny%3BPaschke%2C+Ralf%3BKrause%2C+Gerd%3BThomas%2C+Craig+J%3BGershengorn%2C+Marvin+C&rft.aulast=Moore&rft.aufirst=Susanna&rft.date=2006-06-29&rft.volume=49&rft.issue=13&rft.spage=3888&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Dec 3;279(49):51590-600 [15345720] Mol Endocrinol. 1999 Feb;13(2):181-90 [9973249] J Med Chem. 2004 Oct 21;47(22):5393-404 [15481977] N Engl J Med. 2005 Mar 3;352(9):905-17 [15745981] J Med Chem. 2005 Mar 24;48(6):1697-700 [15771412] J Biol Chem. 2006 Apr 14;281(15):9841-4 [16488885] Acc Chem Res. 2000 Dec;33(12):879-88 [11123887] Physiol Rev. 2002 Apr;82(2):473-502 [11917095] Endocr Rev. 2004 Apr;25(2):235-75 [15082521] Biochem Biophys Res Commun. 1989 Dec 29;165(3):1250-5 [2610690] Chembiochem. 2002 Oct 4;3(10):1023-6 [12362369] J Comb Chem. 2004 Mar-Apr;6(2):196-206 [15002967] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - OLIG2+ Neuroepithelial Progenitors of Motoneurons and Oligodendrocytes are Not Self-Renewing Stem Cells In Vivo T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40243027; 4352830 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Mukoyama, Yosuke AU - Deneen, Benjamin AU - Lukaszewicz, AgnA"s AU - Anderson, David J Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Stem cells KW - Oligodendrocytes KW - Motor neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40243027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=OLIG2%2B+Neuroepithelial+Progenitors+of+Motoneurons+and+Oligodendrocytes+are+Not+Self-Renewing+Stem+Cells+In+Vivo&rft.au=Mukoyama%2C+Yosuke%3BDeneen%2C+Benjamin%3BLukaszewicz%2C+AgnA%22s%3BAnderson%2C+David+J&rft.aulast=Mukoyama&rft.aufirst=Yosuke&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimization of Chondrogenic Differentiation of Human Mesenchymal Stem Cells In Vitro by Co-Treatment with BMP-4 and TGF-Beta3 T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40242583; 4353744 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Morgan, Meredith T AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Bone morphogenetic protein 4 KW - Differentiation KW - Mesenchyme KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40242583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Optimization+of+Chondrogenic+Differentiation+of+Human+Mesenchymal+Stem+Cells+In+Vitro+by+Co-Treatment+with+BMP-4+and+TGF-Beta3&rft.au=Morgan%2C+Meredith+T%3BTuan%2C+Rocky+S&rft.aulast=Morgan&rft.aufirst=Meredith&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Signature Genes that can Distinguish between Mouse ES and EG Cells by Microarray Analysis T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40242068; 4353587 DE: JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Sharova, Lioudmila V AU - Sharov, Alexei A AU - Piao, Yulan AU - Shaik, Nabeebi AU - Sullivan, Terry AU - Stewart, Colin L AU - Hogan, Brigid L.M. AU - Ko, Minoru S.H. Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40242068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Identification+of+Signature+Genes+that+can+Distinguish+between+Mouse+ES+and+EG+Cells+by+Microarray+Analysis&rft.au=Sharova%2C+Lioudmila+V%3BSharov%2C+Alexei+A%3BPiao%2C+Yulan%3BShaik%2C+Nabeebi%3BSullivan%2C+Terry%3BStewart%2C+Colin+L%3BHogan%2C+Brigid+L.M.%3BKo%2C+Minoru+S.H.&rft.aulast=Sharova&rft.aufirst=Lioudmila&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Oct4 and Sox2 Transcription Targets in Human Embryonic Stem Cells T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40241416; 4353665 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Greer Card, Deborah A AU - Li, Leping AU - Archer, Trevor K Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Transcription KW - Oct-4 protein KW - Embryo cells KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Novel+Oct4+and+Sox2+Transcription+Targets+in+Human+Embryonic+Stem+Cells&rft.au=Greer+Card%2C+Deborah+A%3BLi%2C+Leping%3BArcher%2C+Trevor+K&rft.aulast=Greer+Card&rft.aufirst=Deborah&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Canonical and Non-Canonical Wnts Enhance Chondrogenesis of Adult Mesenchymal Stem Cells. T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40241411; 4353542 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Smith, Hana H AU - Chen, Faye H AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Wnt protein KW - Chondrogenesis KW - Mesenchyme KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Canonical+and+Non-Canonical+Wnts+Enhance+Chondrogenesis+of+Adult+Mesenchymal+Stem+Cells.&rft.au=Smith%2C+Hana+H%3BChen%2C+Faye+H%3BTuan%2C+Rocky+S&rft.aulast=Smith&rft.aufirst=Hana&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mesenchymal Stem Cell Differentiation into Endothelial Cells T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40238402; 4353260 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Lozito, Thomas P AU - Kuo, Catherine K AU - Taboas, Juan M AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Differentiation KW - Endothelial cells KW - Mesenchyme KW - Stem cells KW - Cell differentiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40238402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Mesenchymal+Stem+Cell+Differentiation+into+Endothelial+Cells&rft.au=Lozito%2C+Thomas+P%3BKuo%2C+Catherine+K%3BTaboas%2C+Juan+M%3BTuan%2C+Rocky+S&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wnt Signaling Regulates the Balance between Hematopoietic Stem Cell Self-Renewal and Differentiation T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40237531; 4353357 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Nemeth, Michae AU - Bodine, David Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Signal transduction KW - Wnt protein KW - Differentiation KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40237531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Wnt+Signaling+Regulates+the+Balance+between+Hematopoietic+Stem+Cell+Self-Renewal+and+Differentiation&rft.au=Nemeth%2C+Michae%3BBodine%2C+David&rft.aulast=Nemeth&rft.aufirst=Michae&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CDX Family Members Function Redundantly during Embryonic Hematopoiesis T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40237059; 4353334 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Wang, Yuan AU - Yabuuchi, Akiko AU - McKinney-Freeman, Shannon AU - Lengerke, Claudia AU - Archer, Trevor AU - Daley, George Q Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Hemopoiesis KW - Embryos UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40237059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=CDX+Family+Members+Function+Redundantly+during+Embryonic+Hematopoiesis&rft.au=Wang%2C+Yuan%3BYabuuchi%2C+Akiko%3BMcKinney-Freeman%2C+Shannon%3BLengerke%2C+Claudia%3BArcher%2C+Trevor%3BDaley%2C+George+Q&rft.aulast=Wang&rft.aufirst=Yuan&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro Generation and Repopulation of Murine Embryonic Stem Cell-Derived Hepatocytes in Damaged Liver T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40236568; 4353228 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Heo, Jeonghoon AU - Factor, Valentina M AU - Uren, Tania AU - Takahama, Yasushi AU - Major, Marian AU - Feinstone, Stephen M AU - Thorgeirsson, Snorri S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Liver KW - Embryos KW - Hepatocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40236568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Therapeutic+Potential+of+Bone+Marrow+Mesenchymal+Stem+Cells&rft.au=Shi%2C+S&rft.aulast=Shi&rft.aufirst=S&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An in Situ Hybridization-Based Screen for Heterogeneously Expressed Transcription Factor Genes in Mouse ES Cell Cultures. T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40234448; 4353021 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Carter, Mark G AU - Falco, Geppin AU - Stagg, Carole A AU - Bassey, Uwem C AU - Aiba, Kazuhir AU - Matoba, Ry AU - Ko, Minoru S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Cell culture KW - Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40234448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=An+in+Situ+Hybridization-Based+Screen+for+Heterogeneously+Expressed+Transcription+Factor+Genes+in+Mouse+ES+Cell+Cultures.&rft.au=Carter%2C+Mark+G%3BFalco%2C+Geppin%3BStagg%2C+Carole+A%3BBassey%2C+Uwem+C%3BAiba%2C+Kazuhir%3BMatoba%2C+Ry%3BKo%2C+Minoru+S&rft.aulast=Carter&rft.aufirst=Mark&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Umbilical Cord Perivascrular Cells as a Mesenchymal Stem Cell Source: Proliferative and Multilineage Differentiation Potential T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40233086; 4353462 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Baksh, Dolore AU - Yao, Raphae AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Differentiation KW - Umbilical cord KW - Mesenchyme KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40233086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Human+Umbilical+Cord+Perivascrular+Cells+as+a+Mesenchymal+Stem+Cell+Source%3A+Proliferative+and+Multilineage+Differentiation+Potential&rft.au=Baksh%2C+Dolore%3BYao%2C+Raphae%3BTuan%2C+Rocky+S&rft.aulast=Baksh&rft.aufirst=Dolore&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Osteoblasts as Regulators of Adult Human Mesenchymal Stem Cell Osteogenesis T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40232773; 4353379 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Kolf, Catherine M AU - Song, Li AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Osteogenesis KW - Osteoblasts KW - Mesenchyme KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40232773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Osteoblasts+as+Regulators+of+Adult+Human+Mesenchymal+Stem+Cell+Osteogenesis&rft.au=Kolf%2C+Catherine+M%3BSong%2C+Li%3BTuan%2C+Rocky+S&rft.aulast=Kolf&rft.aufirst=Catherine&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Sensitive and Specific Method for Detecting G-Protein Coupled Receptor Mrnas: Receptors Associated with Human Bone Marrow Stromal Cells T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40232684; 4352987 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Hansen, Arne AU - Chen, Yidong AU - Inman, Jason M AU - Phan, Quang N AU - Qi, Zhi-Qing AU - Xiang, Charlie C AU - Kuznetsov, Sergei A AU - Cherman, Natasha AU - Robey, Pamela G AU - Brownstein, Michael J Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Bone marrow KW - Stromal cells KW - ^AG protein-coupled receptors KW - MRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40232684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=A+Sensitive+and+Specific+Method+for+Detecting+G-Protein+Coupled+Receptor+Mrnas%3A+Receptors+Associated+with+Human+Bone+Marrow+Stromal+Cells&rft.au=Hansen%2C+Arne%3BChen%2C+Yidong%3BInman%2C+Jason+M%3BPhan%2C+Quang+N%3BQi%2C+Zhi-Qing%3BXiang%2C+Charlie+C%3BKuznetsov%2C+Sergei+A%3BCherman%2C+Natasha%3BRobey%2C+Pamela+G%3BBrownstein%2C+Michael+J&rft.aulast=Hansen&rft.aufirst=Arne&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucocorticoid Receptor Modulates Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells through Direct Interaction with TGF-Beta Signaling Mediators Smads T2 - 4th Annual Meeting of the International Society for Stem Cell Research AN - 40230642; 4353029 JF - 4th Annual Meeting of the International Society for Stem Cell Research AU - Derfoul, Assi AU - Jones-Isaac, Kendan A AU - Tuan, Rocky S Y1 - 2006/06/29/ PY - 2006 DA - 2006 Jun 29 KW - Signal transduction KW - Differentiation KW - Transforming growth factor-b KW - Smad protein KW - Mesenchyme KW - Stem cells KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40230642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Glucocorticoid+Receptor+Modulates+Chondrogenic+Differentiation+of+Adult+Human+Mesenchymal+Stem+Cells+through+Direct+Interaction+with+TGF-Beta+Signaling+Mediators+Smads&rft.au=Derfoul%2C+Assi%3BJones-Isaac%2C+Kendan+A%3BTuan%2C+Rocky+S&rft.aulast=Derfoul&rft.aufirst=Assi&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={743B38D5- 9EAD-49CC-B2C5-497EBCE87271}&AKey={70E49A1A-9665-43B3-8BAA-55C6A8F9A 624} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40162131; 4306480 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Shi, S Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Bone marrow KW - Mesenchyme KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40162131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Therapeutic+Potential+of+Bone+Marrow+Mesenchymal+Stem+Cells&rft.au=Shi%2C+S&rft.aulast=Shi&rft.aufirst=S&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rescue of Predentin Phenotype in Dentin Sialophosphoprotein Knockout Mice T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40161193; 4307481 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Kulkarni, A B AU - Haruyama, N AU - Honeycutt, C AU - Wang, Z AU - Wang, Y AU - Bi, Y. AU - Young, M AU - Sreenath, T Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Mice KW - Dentin KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40161193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Rescue+of+Predentin+Phenotype+in+Dentin+Sialophosphoprotein+Knockout+Mice&rft.au=Kulkarni%2C+A+B%3BHaruyama%2C+N%3BHoneycutt%2C+C%3BWang%2C+Z%3BWang%2C+Y%3BBi%2C+Y.%3BYoung%2C+M%3BSreenath%2C+T&rft.aulast=Kulkarni&rft.aufirst=A&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epiprofin, a Transcription Factor Expressed in Ectoderm Organs, is Essential T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40160758; 4306901 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Nakamura, T Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Organs KW - Ectoderm KW - Transcription factors KW - Skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40160758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Epiprofin%2C+a+Transcription+Factor+Expressed+in+Ectoderm+Organs%2C+is+Essential&rft.au=Nakamura%2C+T&rft.aulast=Nakamura&rft.aufirst=T&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Oral Cancer Growth and Progression by AKT/MTOR Signaling T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40147570; 4306071 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Gutkind, J S Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Cancer KW - Signal transduction KW - AKT protein KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40147570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Regulation+of+Oral+Cancer+Growth+and+Progression+by+AKT%2FMTOR+Signaling&rft.au=Gutkind%2C+J+S&rft.aulast=Gutkind&rft.aufirst=J&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Congress+on+Gastrointestinal+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tempol Provides Selective Protection to Normal Tissue during Fractionated Irradiation T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40143362; 4305313 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Cotrim, A P AU - Sowers, A AU - Hyodo, F AU - Krishna, M C AU - Mitchell, J B AU - Baum, B J Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Irradiation KW - Radiation KW - Tempol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40143362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Tempol+Provides+Selective+Protection+to+Normal+Tissue+during+Fractionated+Irradiation&rft.au=Cotrim%2C+A+P%3BSowers%2C+A%3BHyodo%2C+F%3BKrishna%2C+M+C%3BMitchell%2C+J+B%3BBaum%2C+B+J&rft.aulast=Cotrim&rft.aufirst=A&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interbacterial Interactions in Early Supragingival Biofilms T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40137416; 4305505 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Palmer, R Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Biofilms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40137416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Interbacterial+Interactions+in+Early+Supragingival+Biofilms&rft.au=Palmer%2C+R&rft.aulast=Palmer&rft.aufirst=R&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Leucine-Rich Amelogenin Peptide Interactions and In Vivo Functions T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40132985; 4305818 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Haruyama, N AU - Sreenath, T AU - Cho, A AU - Hatakeyama, J AU - Kulkarni, A B Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Peptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Leucine-Rich+Amelogenin+Peptide+Interactions+and+In+Vivo+Functions&rft.au=Haruyama%2C+N%3BSreenath%2C+T%3BCho%2C+A%3BHatakeyama%2C+J%3BKulkarni%2C+A+B&rft.aulast=Haruyama&rft.aufirst=N&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mesenchymal Stem Cell-Mediated Dental Tissue Regeneration T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40126503; 4306904 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Shi, S Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Mesenchyme KW - Teeth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40126503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Congress+on+Gastrointestinal+Cancer&rft.atitle=Activity+of+Cetuximab+in+Patients+with+Colorectal+Cancer+Refractory+to+Both-Irinotecan+and+5-+Fluorouracil.The+First+NCIS+Experience&rft.au=Salek%2C+T%3BHlavata%2C+Z%3BSufliarsky%2C+J%3BMardiak%2C+J%3BDolinsky%2C+J%3BReckova%2C+M&rft.aulast=Salek&rft.aufirst=T&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Congress+on+Gastrointestinal+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bevacizumab with Chemotherapy for the First-Line Treatment of Metastatic Colorectal Cancer: "NCI Slovakia ' Results T2 - 8th World Congress on Gastrointestinal Cancer AN - 40115599; 4262789 JF - 8th World Congress on Gastrointestinal Cancer AU - Dolinsky, J AU - Salek, T AU - Hlavata, Z AU - Ivancova, H AU - Risnyovszka, Z AU - Mardiak, J AU - Koza, I Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Chemotherapy KW - Colorectal cancer KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40115599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Congress+on+Gastrointestinal+Cancer&rft.atitle=Bevacizumab+with+Chemotherapy+for+the+First-Line+Treatment+of+Metastatic+Colorectal+Cancer%3A+%22NCI+Slovakia+%27+Results&rft.au=Dolinsky%2C+J%3BSalek%2C+T%3BHlavata%2C+Z%3BIvancova%2C+H%3BRisnyovszka%2C+Z%3BMardiak%2C+J%3BKoza%2C+I&rft.aulast=Dolinsky&rft.aufirst=J&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Congress+on+Gastrointestinal+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.worldgicancer.com/WCGI/WGIC06/pdf_versions/WGI_TOC_041306_w ith_Titles.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Succession of Veillonellae within a Human Oral Biofilm T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40110840; 4305533 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Palmer, R AU - Diaz, P AU - Kolenbrander, P Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Biofilms KW - Succession UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40110840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Canonical+and+Non-Canonical+Wnts+Enhance+Chondrogenesis+of+Adult+Mesenchymal+Stem+Cells.&rft.au=Smith%2C+Hana+H%3BChen%2C+Faye+H%3BTuan%2C+Rocky+S&rft.aulast=Smith&rft.aufirst=Hana&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heparan Sulfate Regulates FGF10 Function during Submandibular Gland Epithelial Morphogenesis T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40095199; 4306336 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Patel, V N AU - Cowherd, S N AU - Hoffman, M P Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Sulfate KW - Fibroblast growth factor 10 KW - Heparan sulfate KW - Morphogenesis KW - Submandibular gland KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Heparan+Sulfate+Regulates+FGF10+Function+during+Submandibular+Gland+Epithelial+Morphogenesis&rft.au=Patel%2C+V+N%3BCowherd%2C+S+N%3BHoffman%2C+M+P&rft.aulast=Patel&rft.aufirst=V&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Cetuximab in Patients with Colorectal Cancer Refractory to Both-Irinotecan and 5- Fluorouracil.The First NCIS Experience T2 - 8th World Congress on Gastrointestinal Cancer AN - 40085015; 4262821 JF - 8th World Congress on Gastrointestinal Cancer AU - Salek, T AU - Hlavata, Z AU - Sufliarsky, J AU - Mardiak, J AU - Dolinsky, J AU - Reckova, M Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Colorectal cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40085015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Congress+on+Gastrointestinal+Cancer&rft.atitle=Activity+of+Cetuximab+in+Patients+with+Colorectal+Cancer+Refractory+to+Both-Irinotecan+and+5-+Fluorouracil.The+First+NCIS+Experience&rft.au=Salek%2C+T%3BHlavata%2C+Z%3BSufliarsky%2C+J%3BMardiak%2C+J%3BDolinsky%2C+J%3BReckova%2C+M&rft.aulast=Salek&rft.aufirst=T&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Congress+on+Gastrointestinal+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.worldgicancer.com/WCGI/WGIC06/pdf_versions/WGI_TOC_041306_w ith_Titles.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - UGT1A1 Promoter Polymorphisms and Pharmacodynamic/Pharmacokinetic Relationship in Advanced Colorectal Cancer Treated with Folfiri Regimen T2 - 8th World Congress on Gastrointestinal Cancer AN - 40072961; 4262610 JF - 8th World Congress on Gastrointestinal Cancer AU - Toffoli, G AU - Corona, G AU - Cecchin, E AU - Masier, S AU - Luigi, S AU - Buonadonna, A AU - Azzarello, G AU - Vincenzo, D AU - Da Corte, D AU - Pasetto, L Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Colorectal cancer KW - Pharmacokinetics KW - Gene polymorphism KW - Pharmacodynamics KW - Pharmacology KW - Promoters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40072961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Congress+on+Gastrointestinal+Cancer&rft.atitle=UGT1A1+Promoter+Polymorphisms+and+Pharmacodynamic%2FPharmacokinetic+Relationship+in+Advanced+Colorectal+Cancer+Treated+with+Folfiri+Regimen&rft.au=Toffoli%2C+G%3BCorona%2C+G%3BCecchin%2C+E%3BMasier%2C+S%3BLuigi%2C+S%3BBuonadonna%2C+A%3BAzzarello%2C+G%3BVincenzo%2C+D%3BDa+Corte%2C+D%3BPasetto%2C+L&rft.aulast=Toffoli&rft.aufirst=G&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Congress+on+Gastrointestinal+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.worldgicancer.com/WCGI/WGIC06/pdf_versions/WGI_TOC_041306_w ith_Titles.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. AN - 68575593; 16777967 AB - Multidrug resistance mechanisms underlying the intractability of malignant melanomas remain largely unknown. In this study, we demonstrate that the development of multidrug resistance in melanomas involves subcellular sequestration of intracellular cytotoxic drugs such as cis-diaminedichloroplatinum II (cisplatin; CDDP). CDDP is initially sequestered in subcellular organelles such as melanosomes, which significantly reduces its nuclear localization when compared with nonmelanoma/KB-3-1 epidermoid carcinoma cells. The melanosomal accumulation of CDDP remarkably modulates melanogenesis through a pronounced increase in tyrosinase activity. The altered melanogenesis manifested an approximately 8-fold increase in both intracellular pigmentation and extracellular transport of melanosomes containing CDDP. Thus, our experiments provide evidence that melanosomes contribute to the refractory properties of melanoma cells by sequestering cytotoxic drugs and increasing melanosome-mediated drug export. Preventing melanosomal sequestration of cytotoxic drugs by inhibiting the functions of melanosomes may have great potential as an approach to improving the chemosensitivity of melanoma cells. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Chen, Kevin G AU - Valencia, Julio C AU - Lai, Barry AU - Zhang, Guofeng AU - Paterson, Jill K AU - Rouzaud, François AU - Berens, Werner AU - Wincovitch, Stephen M AU - Garfield, Susan H AU - Leapman, Richard D AU - Hearing, Vincent J AU - Gottesman, Michael M AD - Laboratories of Cell Biology and Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/06/27/ PY - 2006 DA - 2006 Jun 27 SP - 9903 EP - 9907 VL - 103 IS - 26 SN - 0027-8424, 0027-8424 KW - Antineoplastic Agents KW - 0 KW - Indoles KW - melanogen KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Cytoplasm -- metabolism KW - Humans KW - Biological Transport KW - Indoles -- metabolism KW - Cell Line, Tumor KW - Cytoplasm -- chemistry KW - Melanoma -- ultrastructure KW - Melanosomes -- enzymology KW - Skin Neoplasms -- ultrastructure KW - Melanosomes -- chemistry KW - Antineoplastic Agents -- metabolism KW - Antineoplastic Agents -- analysis KW - Drug Resistance, Neoplasm KW - Cisplatin -- analysis KW - Skin Neoplasms -- metabolism KW - Melanoma -- metabolism KW - Cisplatin -- metabolism KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68575593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Melanosomal+sequestration+of+cytotoxic+drugs+contributes+to+the+intractability+of+malignant+melanomas.&rft.au=Chen%2C+Kevin+G%3BValencia%2C+Julio+C%3BLai%2C+Barry%3BZhang%2C+Guofeng%3BPaterson%2C+Jill+K%3BRouzaud%2C+Fran%C3%A7ois%3BBerens%2C+Werner%3BWincovitch%2C+Stephen+M%3BGarfield%2C+Susan+H%3BLeapman%2C+Richard+D%3BHearing%2C+Vincent+J%3BGottesman%2C+Michael+M&rft.aulast=Chen&rft.aufirst=Kevin&rft.date=2006-06-27&rft.volume=103&rft.issue=26&rft.spage=9903&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-23 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] CA Cancer J Clin. 2005 Jan-Feb;55(1):10-30 [15661684] J Cell Physiol. 2000 Apr;183(1):108-16 [10699972] Melanoma Res. 2000 Oct;10(5):499-505 [11095412] J Investig Med. 2001 Sep;49(5):421-33 [11523698] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10698-703 [11526213] Cancer Metastasis Rev. 2001;20(1-2):3-11 [11831644] Recent Results Cancer Res. 2003;161:93-110 [12528802] Br J Cancer. 2003 Apr 22;88(8):1327-34 [12698203] Cancer Res. 2003 Apr 15;63(8):1776-9 [12702562] Oncogene. 2003 May 19;22(20):3138-51 [12789290] Pigment Cell Res. 2003 Aug;16(4):351-4 [12859618] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Biochem J. 1976 Sep 1;157(3):549-57 [825109] Cancer Res. 1994 Sep 15;54(18):4980-7 [7915196] Anal Biochem. 1999 Jun 1;270(2):207-19 [10334838] J Dermatol Sci. 2005 Jan;37(1):3-14 [15619429] J Cell Physiol. 2005 Mar;202(3):635-41 [15546142] Pigment Cell Res. 2005 Apr;18(2):102-12 [15760339] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative and integrative functional genomics of HCC. AN - 68569374; 16799621 AB - Global gene expression profiling of hepatocellular carcinoma (HCC) is a promising new technology that has already refined the diagnosis and prognostic predictions of HCC patients. This has been accomplished by identifying genes whose expression pattern is associated with clinicopathological features of HCC tumors. Molecular characterization of HCC from gene expression profiling studies will undoubtedly improve the prediction of treatment responses, selection of treatments for specific molecular subtypes of HCC and ultimately the clinical outcome of HCC patients. The research focus is now shifting toward the identification of genetic determinants that are components of the specific regulatory pathways altered in cancers, and that may constitute novel therapeutic targets. Here we review the recent advances in gene expression profiling of HCC and discuss the future strategies for analysing large and complicated data sets from microarray studies and how to integrate these with diverse genomic data. JF - Oncogene AU - Lee, J-S AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA. Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 SP - 3801 EP - 3809 VL - 25 IS - 27 SN - 0950-9232, 0950-9232 KW - Index Medicus KW - Animals KW - Humans KW - Gene Expression Profiling -- trends KW - Gene Expression Profiling -- methods KW - Gene Expression Regulation, Neoplastic KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- genetics KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68569374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Comparative+and+integrative+functional+genomics+of+HCC.&rft.au=Lee%2C+J-S%3BThorgeirsson%2C+S+S&rft.aulast=Lee&rft.aufirst=J-S&rft.date=2006-06-26&rft.volume=25&rft.issue=27&rft.spage=3801&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - New Agents for Drug Resistant Tuberculosis (TB) T2 - 2006 Annual Conference on Antimicrobial Resistance AN - 40206421; 4334894 JF - 2006 Annual Conference on Antimicrobial Resistance AU - Goldman, R AU - Laughon, B AU - Franzblau, S AU - Krahenbuhl, J AU - Lenaerts, A AU - Orme, I AU - Secrist, J AU - Young, L AU - Plumley, K AU - Lambros, C Y1 - 2006/06/26/ PY - 2006 DA - 2006 Jun 26 KW - Tuberculosis KW - Drug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40206421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=New+Agents+for+Drug+Resistant+Tuberculosis+%28TB%29&rft.au=Goldman%2C+R%3BLaughon%2C+B%3BFranzblau%2C+S%3BKrahenbuhl%2C+J%3BLenaerts%2C+A%3BOrme%2C+I%3BSecrist%2C+J%3BYoung%2C+L%3BPlumley%2C+K%3BLambros%2C+C&rft.aulast=Goldman&rft.aufirst=R&rft.date=2006-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance06abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community Urbanization and Hospitalization of Adults for Asthma T2 - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AN - 40176353; 4323175 JF - 70th Annual Educational Conference and Exhibition of the National Environmental Health Association (AEC 2006) AU - Ramos, Rosemarie G Y1 - 2006/06/25/ PY - 2006 DA - 2006 Jun 25 KW - Urbanization KW - Respiratory diseases KW - Asthma KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40176353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.atitle=Community+Urbanization+and+Hospitalization+of+Adults+for+Asthma&rft.au=Ramos%2C+Rosemarie+G&rft.aulast=Ramos&rft.aufirst=Rosemarie&rft.date=2006-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Educational+Conference+and+Exhibition+of+the+National+Environmental+Health+Association+%28AEC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neha.org/AEC/2006/attendees/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Messages and Dietary Fat: Making Sense of the Women's Health Initiative Findings T2 - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 40118102; 4292873 JF - 2006 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Milner, J Y1 - 2006/06/24/ PY - 2006 DA - 2006 Jun 24 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40118102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Public+Health+Messages+and+Dietary+Fat%3A+Making+Sense+of+the+Women%27s+Health+Initiative+Findings&rft.au=Milner%2C+J&rft.aulast=Milner&rft.aufirst=J&rft.date=2006-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.am-fe.ift.org/cms/?pid=1000286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. AN - 68106773; 16791201 AB - SMAD4 (MAD homologue 4 (Drosophila)), also known as DPC4 (deleted in pancreatic cancer), is a tumour suppressor gene that encodes a central mediator of transforming growth factor-beta signalling. Germline mutations in SMAD4 are found in over 50% of patients with familial juvenile polyposis, an autosomal dominant disorder characterized by predisposition to hamartomatous polyps and gastrointestinal cancer. Dense inflammatory cell infiltrates underlay grossly normal appearing, non-polypoid colonic and gastric mucosa of patients with familial juvenile polyposis. This prominent stromal component suggests that loss of SMAD4-dependent signalling in cells within the epithelial microenvironment has an important role in the evolution of intestinal tumorigenesis in this syndrome. Here we show that selective loss of Smad4-dependent signalling in T cells leads to spontaneous epithelial cancers throughout the gastrointestinal tract in mice, whereas epithelial-specific deletion of the Smad4 gene does not. Tumours arising within the colon, rectum, duodenum, stomach and oral cavity are stroma-rich with dense plasma cell infiltrates. Smad4(-/-) T cells produce abundant T(H)2-type cytokines including interleukin (IL)-5, IL-6 and IL-13, known mediators of plasma cell and stromal expansion. The results support the concept that cancer, as an outcome, reflects the loss of the normal communication between the cellular constituents of a given organ, and indicate that Smad4-deficient T cells ultimately send the wrong message to their stromal and epithelial neighbours. JF - Nature AU - Kim, Byung-Gyu AU - Li, Cuiling AU - Qiao, Wenhui AU - Mamura, Mizuko AU - Kasprzak, Barbara AU - Kasperczak, Barbara AU - Anver, Miriam AU - Wolfraim, Lawrence AU - Hong, Suntaek AU - Mushinski, Elizabeth AU - Potter, Michael AU - Kim, Seong-Jin AU - Fu, Xin-Yuan AU - Deng, Chuxia AU - Letterio, John J AD - Laboratory of Cell Regulation and Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/06/22/ PY - 2006 DA - 2006 Jun 22 SP - 1015 EP - 1019 VL - 441 IS - 7096 KW - Cytokines KW - 0 KW - Smad4 Protein KW - Smad4 protein, mouse KW - Index Medicus KW - Adenomatous Polyposis Coli -- pathology KW - Animals KW - Adenomatous Polyposis Coli -- etiology KW - Adenomatous Polyposis Coli -- genetics KW - Neoplasms, Glandular and Epithelial -- metabolism KW - Cytokines -- biosynthesis KW - Disease Models, Animal KW - Mice KW - Neoplasms, Glandular and Epithelial -- pathology KW - Gene Deletion KW - Mice, Inbred C57BL KW - Cell Communication KW - Neoplasms, Glandular and Epithelial -- immunology KW - Gene Targeting KW - Smad4 Protein -- metabolism KW - T-Lymphocytes -- metabolism KW - Smad4 Protein -- genetics KW - Gastrointestinal Neoplasms -- pathology KW - Gastrointestinal Neoplasms -- metabolism KW - Signal Transduction KW - Gastrointestinal Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Smad4+signalling+in+T+cells+is+required+for+suppression+of+gastrointestinal+cancer.&rft.au=Kim%2C+Byung-Gyu%3BLi%2C+Cuiling%3BQiao%2C+Wenhui%3BMamura%2C+Mizuko%3BKasprzak%2C+Barbara%3BKasperczak%2C+Barbara%3BAnver%2C+Miriam%3BWolfraim%2C+Lawrence%3BHong%2C+Suntaek%3BMushinski%2C+Elizabeth%3BPotter%2C+Michael%3BKim%2C+Seong-Jin%3BFu%2C+Xin-Yuan%3BDeng%2C+Chuxia%3BLetterio%2C+John+J&rft.aulast=Kim&rft.aufirst=Byung-Gyu&rft.date=2006-06-22&rft.volume=441&rft.issue=7096&rft.spage=1015&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Nature. 2006 Dec 7;444(7120):780 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Is what you Eat Important? T2 - Second American Congress of Epidemiology AN - 40114113; 4251432 JF - Second American Congress of Epidemiology AU - Chew, Emily Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Macular degeneration KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+American+Congress+of+Epidemiology&rft.atitle=Is+what+you+Eat+Important%3F&rft.au=Chew%2C+Emily&rft.aulast=Chew&rft.aufirst=Emily&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.epicongress2006.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Outcomes in Neonatal Onset Multisystem Inflammatory Disease (Nomid) after 12 Months of Treatment with the Recombinant Il-1 Receptor Antagonist Anakinra T2 - 2006 Annual European Congress of Rheumatology (EULAR 2006) AN - 40090060; 4265835 JF - 2006 Annual European Congress of Rheumatology (EULAR 2006) AU - Paul, S M AU - Namde, M AU - Hildebrand, H AU - Jain, M AU - Smith, M AU - Canna, S AU - Wiggs, E AU - Comis, L AU - Goldbach-Mansky, R Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Neonates KW - Inflammatory diseases KW - Disease control KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40090060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.atitle=Functional+Outcomes+in+Neonatal+Onset+Multisystem+Inflammatory+Disease+%28Nomid%29+after+12+Months+of+Treatment+with+the+Recombinant+Il-1+Receptor+Antagonist+Anakinra&rft.au=Paul%2C+S+M%3BNamde%2C+M%3BHildebrand%2C+H%3BJain%2C+M%3BSmith%2C+M%3BCanna%2C+S%3BWiggs%2C+E%3BComis%2C+L%3BGoldbach-Mansky%2C+R&rft.aulast=Paul&rft.aufirst=S&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eular.org/eular2006/newsDisplay.cfm?id=68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SLE CD4 T Cells Display Distinct Abnormalities in Memory Cell Maturation T2 - 2006 Annual European Congress of Rheumatology (EULAR 2006) AN - 40047043; 4265268 JF - 2006 Annual European Congress of Rheumatology (EULAR 2006) AU - Fritsch-Stork, R D AU - Shen, X AU - Illei, G G AU - Yarboro, C H AU - Prussin, C AU - Hathcock, K S AU - Hodes, R J AU - Lipsky, P E Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Memory cells KW - Lymphocytes T KW - CD4 antigen KW - Sexual maturity KW - Abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40047043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.atitle=SLE+CD4+T+Cells+Display+Distinct+Abnormalities+in+Memory+Cell+Maturation&rft.au=Fritsch-Stork%2C+R+D%3BShen%2C+X%3BIllei%2C+G+G%3BYarboro%2C+C+H%3BPrussin%2C+C%3BHathcock%2C+K+S%3BHodes%2C+R+J%3BLipsky%2C+P+E&rft.aulast=Fritsch-Stork&rft.aufirst=R&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eular.org/eular2006/newsDisplay.cfm?id=68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defective Suppressor Function of CD4+CD25HI T Regulatory Cells in Active SLE. T2 - 2006 Annual European Congress of Rheumatology (EULAR 2006) AN - 40040545; 4265255 JF - 2006 Annual European Congress of Rheumatology (EULAR 2006) AU - Valencia, X AU - Simone, J AU - Illei, G AU - Yarboro, C AU - Lipsky, P Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Lymphocytes T KW - Immunoregulation KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.atitle=Defective+Suppressor+Function+of+CD4%2BCD25HI+T+Regulatory+Cells+in+Active+SLE.&rft.au=Valencia%2C+X%3BSimone%2C+J%3BIllei%2C+G%3BYarboro%2C+C%3BLipsky%2C+P&rft.aulast=Valencia&rft.aufirst=X&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eular.org/eular2006/newsDisplay.cfm?id=68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Twelve Months after Treating Children with Neonatal Onset Mutisystem Inflammatory Disease (Nomid/Cinca) with the Il-1 Receptor Antagonist Anakinra T2 - 2006 Annual European Congress of Rheumatology (EULAR 2006) AN - 40029111; 4265814 JF - 2006 Annual European Congress of Rheumatology (EULAR 2006) AU - Namde, M AU - Canna, S AU - Plass, N AU - Aksentijevich, I AU - Rubin, B AU - Kim, J AU - Brewer, C AU - Snyder, C AU - Pham, T AU - Kastner, D AU - Goldbach-Mansky, R Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Children KW - Neonates KW - Inflammatory diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40029111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.atitle=Twelve+Months+after+Treating+Children+with+Neonatal+Onset+Mutisystem+Inflammatory+Disease+%28Nomid%2FCinca%29+with+the+Il-1+Receptor+Antagonist+Anakinra&rft.au=Namde%2C+M%3BCanna%2C+S%3BPlass%2C+N%3BAksentijevich%2C+I%3BRubin%2C+B%3BKim%2C+J%3BBrewer%2C+C%3BSnyder%2C+C%3BPham%2C+T%3BKastner%2C+D%3BGoldbach-Mansky%2C+R&rft.aulast=Namde&rft.aufirst=M&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+European+Congress+of+Rheumatology+%28EULAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eular.org/eular2006/newsDisplay.cfm?id=68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Studies in TNF-Receptor Associated Periodic Syndrome (TRAPS) T2 - 2006 Annual European Congress of Rheumatology (EULAR 2006) AN - 40018091; 4264731 JF - 2006 Annual European Congress of Rheumatology (EULAR 2006) AU - Aksentijevich, I AU - Balow Jr, J AU - Barham, B AU - Kastner, D L Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Gene expression KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40018091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Optimization+of+Chondrogenic+Differentiation+of+Human+Mesenchymal+Stem+Cells+In+Vitro+by+Co-Treatment+with+BMP-4+and+TGF-Beta3&rft.au=Morgan%2C+Meredith+T%3BTuan%2C+Rocky+S&rft.aulast=Morgan&rft.aufirst=Meredith&rft.date=2006-06-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.eular.org/eular2006/newsDisplay.cfm?id=68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strategies for Automated Extraction of Young's Moduli of Soft Materials from Afm Force Curves: Application to Cartilage T2 - 2006 Summer Conference on Bioengineering AN - 39221591; 4261243 JF - 2006 Summer Conference on Bioengineering AU - Lin, David AU - Dimitriadis, Emilios AU - Horkay, Ferenc Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Cartilage KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39221591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Conference+on+Bioengineering&rft.atitle=Strategies+for+Automated+Extraction+of+Young%27s+Moduli+of+Soft+Materials+from+Afm+Force+Curves%3A+Application+to+Cartilage&rft.au=Lin%2C+David%3BDimitriadis%2C+Emilios%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Conference+on+Bioengineering&rft.issn=&rft_id=info:doi/ L2 - http://divisions.asme.org/bed/events/pdffiles/detailedProg06.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lost in Translation: Moving Bioengineering Research to Application for the Benefit of Public Health T2 - 2006 Summer Conference on Bioengineering AN - 39218837; 4261281 JF - 2006 Summer Conference on Bioengineering AU - Kelley, Christine Y1 - 2006/06/21/ PY - 2006 DA - 2006 Jun 21 KW - Public health KW - Translation KW - Biotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39218837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Conference+on+Bioengineering&rft.atitle=Lost+in+Translation%3A+Moving+Bioengineering+Research+to+Application+for+the+Benefit+of+Public+Health&rft.au=Kelley%2C+Christine&rft.aulast=Kelley&rft.aufirst=Christine&rft.date=2006-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Conference+on+Bioengineering&rft.issn=&rft_id=info:doi/ L2 - http://divisions.asme.org/bed/events/pdffiles/detailedProg06.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sudden infant death syndrome. AN - 68094970; 16785462 AB - Sudden infant death syndrome (SIDS) continues to be the most common cause of postneonatal infant death. SIDS is a complex, multifactorial disorder, the cause of which is still not fully understood. However, much is known now about environmental risk factors, some of which are modifiable. These include maternal and antenatal risk factors such as smoking during pregnancy, as well as infant-related risk factors such as non-supine sleeping position and soft bedding. Emerging evidence also substantiates an expanding number of genetic risk factors. Interactions between environmental and genetic risk factors may be of critical importance in determining an infant's actual risk of SIDS. Although no practical way exists to identify which infants will die of SIDS, nor is there a safe and proven prevention strategy even if identification were feasible, reducing exposure to modifiable risk factors has helped to lower the incidence of SIDS. Current challenges include wider dissemination of guidelines to all people who care for infants, dissemination of guidelines in culturally appropriate ways, and surveillance of SIDS trends and other outcomes associated with implementation of these guidelines. JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne AU - Hunt, Carl E AU - Hauck, Fern R AD - National Heart, Lung, and Blood Institute, Bethesda, Md 20892-2480, USA. huntc@nhlbi.nih.gov Y1 - 2006/06/20/ PY - 2006 DA - 2006 Jun 20 SP - 1861 EP - 1869 VL - 174 IS - 13 KW - Abridged Index Medicus KW - Index Medicus KW - Breast Feeding KW - Polymorphism, Genetic KW - Humans KW - Infant, Newborn KW - Bedding and Linens KW - Maternal Exposure KW - Smoking -- epidemiology KW - Pregnancy KW - Socioeconomic Factors KW - Prone Position KW - Risk Factors KW - Pacifiers KW - Female KW - Substance-Related Disorders -- epidemiology KW - Sudden Infant Death -- epidemiology KW - Sudden Infant Death -- genetics KW - Sudden Infant Death -- prevention & control KW - Sudden Infant Death -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68094970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.atitle=Sudden+infant+death+syndrome.&rft.au=Hunt%2C+Carl+E%3BHauck%2C+Fern+R&rft.aulast=Hunt&rft.aufirst=Carl&rft.date=2006-06-20&rft.volume=174&rft.issue=13&rft.spage=1861&rft.isbn=&rft.btitle=&rft.title=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.issn=1488-2329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2003 Mar 1;157(5):446-55 [12615609] Pediatrics. 2003 May;111(5 Pt 2):1207-14 [12728140] Arch Pediatr Adolesc Med. 2003 May;157(5):469-74 [12742883] Neurology. 2003 Nov 11;61(9):1256-9 [14610131] J Neuropathol Exp Neurol. 2003 Nov;62(11):1178-91 [14656075] Arch Dis Child. 2003 Dec;88(12):1058-64 [14670769] Early Hum Dev. 2003 Dec;75 Suppl:S147-66 [14693401] Lancet. 2004 Jan 17;363(9404):185-91 [14738790] Wien Klin Wochenschr. 2003 Dec 30;115(24):887-93 [14768536] Early Hum Dev. 2004 Apr;77(1-2):99-108 [15113636] Pediatrics. 2004 May;113(5):e435-9 [15121986] Pediatrics. 2004 Jun;113(6):e586-92 [15173541] Addict Biol. 2004 Jun;9(2):179-86; 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author reply 1309-10 [17452672] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Harmonic DiffServ: scalable support of IP multicast with QoS heterogeneity in DiffServ backbone networks. AN - 57653509; 486018 AB - The Differentiated Service (DiffServ) has been considered as a scalable approach to provide class-based quality-of-service (QoS) control in Internet. However, the direct implant of DiffServ in IP multicast shows some limitations on supporting a multicast session exhibiting QoS heterogeneity. Also IP multicast by itself has to maintain a large amount of the session-based forwarding information and potentially causes another routing scalability problem in routers. In this paper, we therefore propose a novel adaptation framework, termed harmonic DiffServ, to solve the QoS heterogeneity and routing scalability problems at the same time. In principle, (1) multicast trees are clustered and aggregated into a given number of multicast sessions, and (2) within each multicast session, packets are further marked by a set of undefined DSCPs which lead packets to specific QoS treatments in each router in a way that the respective QoS requirements of multicast trees are realized properly. We propose a heuristic clustering scheme and based on it, two DSCP encoding schemes, namely, the fixed encoding (FE) and the dynamic encoding (DE). Extensive simulations based on different network configurations are conducted. The simulated result reveals that our schemes can effectively reduce the forwarding information and achieve excellent scalability in terms of the number of multicast sessions and DSCP in use. And DE always consumes less number of DSCP than FE at the cost of slightly more computation and control overheads. (Author abstract) JF - Computer Communications AU - Tong, Sheau-Ru AU - Chang, Chun-Cheng AD - Department of Management Information Systems, National Pingtung University of Science and Technology, No. 1, Hseuh-Fu Rd., Nei-Pu Hsiang, Pingtung 91201, Taiwan, ROC srtong@mail.npust.edu.tw Y1 - 2006/06/19/ PY - 2006 DA - 2006 Jun 19 SP - 1780 EP - 1797 PB - Elsevier Ltd (NL) VL - 29 IS - 10 SN - 0140-3664, 0140-3664 KW - Networks KW - Multicasting KW - 14.11: COMMUNICATIONS AND INFORMATION TECHNOLOGY - NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57653509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Communications&rft.atitle=Harmonic+DiffServ%3A+scalable+support+of+IP+multicast+with+QoS+heterogeneity+in+DiffServ+backbone+networks.&rft.au=Tong%2C+Sheau-Ru%3BChang%2C+Chun-Cheng&rft.aulast=Tong&rft.aufirst=Sheau-Ru&rft.date=2006-06-19&rft.volume=29&rft.issue=10&rft.spage=1780&rft.isbn=&rft.btitle=&rft.title=Computer+Communications&rft.issn=01403664&rft_id=info:doi/10.1016%2Fj.comcom.2005.10.016 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-04-23 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Networks; Multicasting DO - http://dx.doi.org/10.1016/j.comcom.2005.10.016 ER - TY - CPAPER T1 - Molecular Mechanism of DNA Mismatch Repair T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40280689; 4382950 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Yang, Wei AU - Lee, Jae Young Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Mismatch repair KW - Molecular modelling KW - DNA repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40280689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Molecular+Mechanism+of+DNA+Mismatch+Repair&rft.au=Yang%2C+Wei%3BLee%2C+Jae+Young&rft.aulast=Yang&rft.aufirst=Wei&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Bax and Bak in Mitochondrial Morphogenesis T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40279018; 4382930 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Norris, Kristi L AU - Karbowski, Mariusz AU - Youle, Richard J Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Mitochondria KW - Bax protein KW - Morphogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40279018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=DNAse+treatment+following+thawing+of+Cryopreserved+PBMC+is+a+procedure+suitable+for+lymphocyte+functional+studies&rft.au=Garcia-Pineres%2C+A+J%3BHildesheim%2C+A%3BWilliams%2C+M%3BTrivett%2C+M%3BStrobl%2C+S%3BPinto%2C+LA&rft.aulast=Garcia-Pineres&rft.aufirst=A&rft.date=2006-06-30&rft.volume=313&rft.issue=1-2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.04.004 L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Metabonomics for the Analysis of P450 Expression In Vivo and Prediction of Drug Metabolism T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40278971; 4382939 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Gonzalez, Frank J AU - Krausz, Kristopher W AU - Chen, Chi AU - Ma, Xiaochao AU - Idle, Jeffrey R Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Metabolism KW - Drugs KW - Drug metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40278971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Mouse+Metabonomics+for+the+Analysis+of+P450+Expression+In+Vivo+and+Prediction+of+Drug+Metabolism&rft.au=Gonzalez%2C+Frank+J%3BKrausz%2C+Kristopher+W%3BChen%2C+Chi%3BMa%2C+Xiaochao%3BIdle%2C+Jeffrey+R&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Changes in Chromatin Structure Allow Rapid Induction of IL-2 Transcription T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40278786; 4383618 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Ishihara, Satoru AU - Schwartz, Ronald H Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Interleukin 2 KW - Transcription KW - Chromatin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40278786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Dynamic+Changes+in+Chromatin+Structure+Allow+Rapid+Induction+of+IL-2+Transcription&rft.au=Ishihara%2C+Satoru%3BSchwartz%2C+Ronald+H&rft.aulast=Ishihara&rft.aufirst=Satoru&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of NRF2 in Susceptibility to Oxidative Stress in the Lung - A Translational Investigation T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40278708; 4382982 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Kleeberger, Steven R Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Lung KW - Stress KW - Oxidative stress KW - Translation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40278708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Role+of+NRF2+in+Susceptibility+to+Oxidative+Stress+in+the+Lung+-+A+Translational+Investigation&rft.au=Kleeberger%2C+Steven+R&rft.aulast=Kleeberger&rft.aufirst=Steven&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD28 Partially Prevents the Proliferative Block, But Has No Effect on the Cytokine Down-Regulation Associated with Adaptive Tolerance T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40266920; 4382087 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Inobe, Manabu AU - Schwartz, Ronald H Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Cytokines KW - CD28 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40266920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=CAAT%2Fenhancer-binding+protein+delta+and+cAMP-response+element-binding+protein+mediate+inducible+expression+of+the+nerve+growth+factor+gene+in+the+central+nervous+system.&rft.au=McCauslin%2C+Christine+Seitz%3BHeath%2C+Victoria%3BColangelo%2C+Anna+Maria%3BMalik%2C+Radek%3BLee%2C+Sook%3BMallei%2C+Alessandra%3BMocchetti%2C+Italo%3BJohnson%2C+Peter+F&rft.aulast=McCauslin&rft.aufirst=Christine&rft.date=2006-06-30&rft.volume=281&rft.issue=26&rft.spage=17681&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accumulation of Rho at the Equatorial Cell Cortex for Contractile Ring Formation T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40266707; 4381112 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Kamijo, Keiju AU - Ohara, Naoya AU - Abe, Mitsuhiro AU - Uchimura, Takashi AU - Hosoya, Hiroshi AU - Lee, Jae-Seon AU - Usuda, Nobuteru AU - Miki, Toru Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Cortex KW - Contractility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40266707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Accumulation+of+Rho+at+the+Equatorial+Cell+Cortex+for+Contractile+Ring+Formation&rft.au=Kamijo%2C+Keiju%3BOhara%2C+Naoya%3BAbe%2C+Mitsuhiro%3BUchimura%2C+Takashi%3BHosoya%2C+Hiroshi%3BLee%2C+Jae-Seon%3BUsuda%2C+Nobuteru%3BMiki%2C+Toru&rft.aulast=Kamijo&rft.aufirst=Keiju&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemokine Receptor Signaling via Gai2 is Critical for Lymphocyte Trafficking T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40265335; 4379860 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Kehrl, John AU - Hwang, Il Young Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Lymphocytes KW - Signal transduction KW - Protein transport KW - Chemokine receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40265335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Chemokine+Receptor+Signaling+via+Gai2+is+Critical+for+Lymphocyte+Trafficking&rft.au=Kehrl%2C+John%3BHwang%2C+Il+Young&rft.aulast=Kehrl&rft.aufirst=John&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mono-ADP-Ribosylation: A Regulatory Modification of Proteins in Health and Disease T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40262537; 4379807 DE: JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Moss, Joel AU - Oka, Shunya AU - Zhu, Jianfeng AU - Stevens, Linda_A. AU - Kato, Jiro Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40262537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Mono-ADP-Ribosylation%3A+A+Regulatory+Modification+of+Proteins+in+Health+and+Disease&rft.au=Moss%2C+Joel%3BOka%2C+Shunya%3BZhu%2C+Jianfeng%3BStevens%2C+Linda_A.%3BKato%2C+Jiro&rft.aulast=Moss&rft.aufirst=Joel&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allele-Specific Activity and Nuclear Gene Positioning during Astrocytogenesis T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40261692; 4379397 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Takizawa, Takumi AU - Gudla, Prabhakar_R AU - Lockett, Stephan_J AU - Misteli, Tom Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Differentiation KW - Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40261692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Allele-Specific+Activity+and+Nuclear+Gene+Positioning+during+Astrocytogenesis&rft.au=Takizawa%2C+Takumi%3BGudla%2C+Prabhakar_R%3BLockett%2C+Stephan_J%3BMisteli%2C+Tom&rft.aulast=Takizawa&rft.aufirst=Takumi&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dimensions and Dynamics in Cell-Matrix Interactions T2 - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AN - 40260655; 4379177 JF - 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (IUBMB 2006) AU - Yamada, Kenneth M AU - Pankov, Roumen AU - Endo, Yukinori AU - Even-Ram, Sharona AU - Matsumoto, Kazue AU - Sakai, Takayoshi AU - Wei, Cindy AU - Larsen, Melinda Y1 - 2006/06/18/ PY - 2006 DA - 2006 Jun 18 KW - Cell adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40260655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.atitle=Dimensions+and+Dynamics+in+Cell-Matrix+Interactions&rft.au=Yamada%2C+Kenneth+M%3BPankov%2C+Roumen%3BEndo%2C+Yukinori%3BEven-Ram%2C+Sharona%3BMatsumoto%2C+Kazue%3BSakai%2C+Takayoshi%3BWei%2C+Cindy%3BLarsen%2C+Melinda&rft.aulast=Yamada&rft.aufirst=Kenneth&rft.date=2006-06-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IUBMB+International+Congress+of+Biochemistry+and+Molecular+Biology+and+11th+congress+of+the+Federation+of+Asian+and+Oceanian+Biochemists+and+Molecular+Biologists+%28IUBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/iubmb/search/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Gene-Environment Interactions can Influence the Development and Expression of Aggression in Macaque Monkeys. T2 - 10th Annual Meeting of the Society for Behavioral Neuroendocrinology AN - 40209365; 4338863 JF - 10th Annual Meeting of the Society for Behavioral Neuroendocrinology AU - Suomi, Stephen Y1 - 2006/06/17/ PY - 2006 DA - 2006 Jun 17 KW - Aggression KW - Aggressive behaviour KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40209365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Meeting+of+the+Society+for+Behavioral+Neuroendocrinology&rft.atitle=How+Gene-Environment+Interactions+can+Influence+the+Development+and+Expression+of+Aggression+in+Macaque+Monkeys.&rft.au=Suomi%2C+Stephen&rft.aulast=Suomi&rft.aufirst=Stephen&rft.date=2006-06-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Meeting+of+the+Society+for+Behavioral+Neuroendocrinology&rft.issn=&rft_id=info:doi/ L2 - http://www.sbne.org/Meeting/2006/Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impairments in Social Dominance in Vasopressin 1B Receptor Knockout Mice. T2 - 10th Annual Meeting of the Society for Behavioral Neuroendocrinology AN - 40205063; 4339065 JF - 10th Annual Meeting of the Society for Behavioral Neuroendocrinology AU - Caldwell, Heather K AU - Storck, Kathryn E AU - Young, W Scott Y1 - 2006/06/17/ PY - 2006 DA - 2006 Jun 17 KW - Mice KW - Vasopressin KW - Dominance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40205063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Meeting+of+the+Society+for+Behavioral+Neuroendocrinology&rft.atitle=Impairments+in+Social+Dominance+in+Vasopressin+1B+Receptor+Knockout+Mice.&rft.au=Caldwell%2C+Heather+K%3BStorck%2C+Kathryn+E%3BYoung%2C+W+Scott&rft.aulast=Caldwell&rft.aufirst=Heather&rft.date=2006-06-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Meeting+of+the+Society+for+Behavioral+Neuroendocrinology&rft.issn=&rft_id=info:doi/ L2 - http://www.sbne.org/Meeting/2006/Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. AN - 68062158; 16606610 AB - Estrogens are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal replacement therapy. Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/androstane receptor (CAR) are important in maintaining bile acid homeostasis and protecting the liver from bile acid toxicity. However, no nuclear receptor has been implicated in the mechanism for estrogen-induced hepatotoxicity. Here Era(-/-), Erb(-/-), Fxr(-/-), Pxr(-/-), and Car(-/-) mice were employed to show that Era(-/-) mice were resistant to synthetic estrogen 17alpha-ethynylestradiol (EE2)-induced hepatotoxicity as indicated by the fact that the EE2-treated Era(-/-) mice developed none of the hepatotoxic phenotypes such as hepatomegaly, elevation in serum bile acids, increase of alkaline phosphatase activity, liver degeneration, and inflammation. Upon EE2 treatment, estrogen receptor alpha (ERalpha) repressed the expression of bile acid and cholesterol transporters (bile salt export pump (BSEP), Na(+)/taurocholate cotransporting polypeptide (NTCP), OATP1, OATP2, ABCG5, and ABCG8) in the liver. Consistently, biliary secretions of both bile acids and cholesterol were markedly decreased in EE2-treated wild-type mice but not in the EE2-treated Era(-/-) mice. In addition, ERalpha up-regulated the expression of CYP7B1 and down-regulated the CYP7A1 and CYP8B1, shifting bile acid synthesis toward the acidic pathway to increase the serum level of beta-muricholic acid. ERbeta, FXR, PXR, and CAR were not involved in regulating the expression of bile acid transporter and biosynthesis enzyme genes following EE2 exposure. Taken together, these results suggest that ERalpha-mediated repression of hepatic transporters and alterations of bile acid biosynthesis may contribute to development of the EE2-induced hepatotoxicity. JF - The Journal of biological chemistry AU - Yamamoto, Yukio AU - Moore, Rick AU - Hess, Holly A AU - Guo, Grace L AU - Gonzalez, Frank J AU - Korach, Kenneth S AU - Maronpot, Robert R AU - Negishi, Masahiko AD - Laboratories of Reproductive and Developmental Toxicology, NIEHS/National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2006/06/16/ PY - 2006 DA - 2006 Jun 16 SP - 16625 EP - 16631 VL - 281 IS - 24 SN - 0021-9258, 0021-9258 KW - Bile Acids and Salts KW - 0 KW - Estrogen Receptor alpha KW - Lipids KW - Ethinyl Estradiol KW - 423D2T571U KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Animals KW - Lipids -- chemistry KW - Cholesterol -- metabolism KW - Humans KW - Mice, Inbred C57BL KW - Mice KW - Bile -- metabolism KW - Mice, Transgenic KW - Models, Biological KW - Bile Acids and Salts -- metabolism KW - Cell Line KW - Liver -- pathology KW - Liver -- metabolism KW - Ethinyl Estradiol -- metabolism KW - Gene Expression Regulation KW - Estrogen Receptor alpha -- metabolism KW - Estrogen Receptor alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68062158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Estrogen+receptor+alpha+mediates+17alpha-ethynylestradiol+causing+hepatotoxicity.&rft.au=Yamamoto%2C+Yukio%3BMoore%2C+Rick%3BHess%2C+Holly+A%3BGuo%2C+Grace+L%3BGonzalez%2C+Frank+J%3BKorach%2C+Kenneth+S%3BMaronpot%2C+Robert+R%3BNegishi%2C+Masahiko&rft.aulast=Yamamoto&rft.aufirst=Yukio&rft.date=2006-06-16&rft.volume=281&rft.issue=24&rft.spage=16625&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer. AN - 68088729; 16778210 AB - Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the predicted toxicities. To address the underlying mechanisms, we have used the 4T1 syngeneic mouse model of metastatic breast cancer. Treatment of mice with a monoclonal anti-TGF-beta antibody (1D11) significantly suppressed metastasis of 4T1 cells to the lungs. When metastatic 4T1 cells were recovered from lungs of 1D11-treated and control mice, the most differentially expressed gene was found to be bone sialoprotein (Bsp). Immunostaining confirmed the loss of Bsp protein in 1D11-treated lung metastases, and TGF-beta was shown to regulate and correlate with Bsp expression in vitro. Functionally, knockdown of Bsp in 4T1 cells reduced the ability of TGF-beta to induce local collagen degradation and invasion in vitro, and treatment with recombinant Bsp protected 4T1 cells from complement-mediated lysis. Finally, suppression of Bsp in 4T1 cells reduced metastasis in vivo. We conclude that Bsp is a plausible mediator of at least some of the tumor cell-targeted prometastatic activity of TGF-beta in this model and that Bsp expression in metastases can be successfully suppressed by systemic treatment with anti-TGF-beta antibodies. JF - Cancer research AU - Nam, Jeong-Seok AU - Suchar, Adam M AU - Kang, Mi-Jin AU - Stuelten, Christina H AU - Tang, Binwu AU - Michalowska, Aleksandra M AU - Fisher, Larry W AU - Fedarko, Neal S AU - Jain, Alka AU - Pinkas, Jan AU - Lonning, Scott AU - Wakefield, Lalage M AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, MD 20892-5055, USA. Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 6327 EP - 6335 VL - 66 IS - 12 SN - 0008-5472, 0008-5472 KW - Antibodies, Monoclonal KW - 0 KW - Ibsp protein, mouse KW - Integrin-Binding Sialoprotein KW - Sialoglycoproteins KW - Transforming Growth Factor beta KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Lung Neoplasms -- prevention & control KW - Down-Regulation KW - Collagen -- metabolism KW - Lung Neoplasms -- secondary KW - Neoplasm Metastasis KW - Disease Models, Animal KW - Mice KW - Mice, Inbred BALB C KW - Antibodies, Monoclonal -- physiology KW - Female KW - Antibodies, Monoclonal -- immunology KW - Transforming Growth Factor beta -- biosynthesis KW - Sialoglycoproteins -- genetics KW - Sialoglycoproteins -- biosynthesis KW - Mammary Neoplasms, Experimental -- genetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Transforming Growth Factor beta -- immunology KW - Transforming Growth Factor beta -- antagonists & inhibitors KW - Mammary Neoplasms, Experimental -- therapy KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68088729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Bone+sialoprotein+mediates+the+tumor+cell-targeted+prometastatic+activity+of+transforming+growth+factor+beta+in+a+mouse+model+of+breast+cancer.&rft.au=Nam%2C+Jeong-Seok%3BSuchar%2C+Adam+M%3BKang%2C+Mi-Jin%3BStuelten%2C+Christina+H%3BTang%2C+Binwu%3BMichalowska%2C+Aleksandra+M%3BFisher%2C+Larry+W%3BFedarko%2C+Neal+S%3BJain%2C+Alka%3BPinkas%2C+Jan%3BLonning%2C+Scott%3BWakefield%2C+Lalage+M&rft.aulast=Nam&rft.aufirst=Jeong-Seok&rft.date=2006-06-15&rft.volume=66&rft.issue=12&rft.spage=6327&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 1999 Dec;5(12):3914-9 [10632320] Crit Rev Oncog. 1999;10(4):303-60 [10654929] J Bone Miner Res. 2000 May;15(5):834-43 [10804012] J Biol Chem. 2000 Jun 2;275(22):16666-72 [10747989] Int J Cancer. 2001 Jan 1;91(1):76-82 [11149423] Biochem Biophys Res Commun. 2001 Jan 19;280(2):460-5 [11162539] Mol Cancer Ther. 2002 Jan;1(3):161-7 [12467210] N Engl J Med. 2002 Dec 19;347(25):1999-2009 [12490681] Cancer Res. 2003 Apr 15;63(8):1860-4 [12702574] Cancer Cell. 2003 Jun;3(6):537-49 [12842083] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Int J Oncol. 2003 Oct;23(4):1043-8 [12963984] J Clin Invest. 2003 Oct;112(7):1116-24 [14523048] Calcif Tissue Int. 2003 Sep;73(3):281-9 [14667142] Biochem Biophys Res Commun. 2004 Apr 2;316(2):461-7 [15020240] FASEB J. 2004 Apr;18(6):734-6 [14766790] Clin Exp Metastasis. 2004;21(1):19-29 [15065599] J Natl Cancer Inst. 2004 Jun 16;96(12):956-65 [15199115] J Biol Chem. 1988 Sep 25;263(27):13916-21 [3166460] J Immunol. 1989 Mar 1;142(5):1536-41 [2537357] Proc Natl Acad Sci U S A. 1990 Oct;87(19):7678-82 [2217201] Cancer Res. 1992 Mar 15;52(6):1399-405 [1540948] J Clin Invest. 1993 Dec;92(6):2569-76 [7504687] Cancer Res. 1994 Jun 1;54(11):2823-6 [8187059] Acta Orthop Scand Suppl. 1995 Oct;266:61-5 [8553864] Int J Cancer. 1996 Aug 22;69(4):350-3 [8797881] J Cell Biochem. 1997 Jun 15;65(4):501-12 [9178100] Calcif Tissue Int. 1997 Sep;61(3):183-8 [9262507] EMBO J. 1998 Jun 1;17(11):3091-100 [9606191] J Natl Cancer Inst. 1998 Jul 1;90(13):1000-8 [9665149] Thyroid. 1998 Aug;8(8):637-41 [9737356] Clin Exp Metastasis. 1999 Mar;17(2):163-70 [10411109] Cytokine. 2005 Jan 21;29(2):84-91 [15598443] Clin Cancer Res. 2004 Dec 15;10(24):8501-11 [15623631] Int J Cancer. 2005 Jun 10;115(2):177-86 [15688393] J Cell Sci. 2005 May 15;118(Pt 10):2143-53 [15855236] Trends Cell Biol. 2006 Feb;16(2):79-87 [16406521] Nat Genet. 2001 Oct;29(2):117-29 [11586292] Clin Exp Metastasis. 2000;18(7):553-60 [11688960] Clin Cancer Res. 2001 Dec;7(12):4060-6 [11751502] Curr Opin Genet Dev. 2002 Feb;12(1):22-9 [11790550] Nature. 2002 Jan 31;415(6871):530-6 [11823860] J Biol Chem. 2002 Apr 19;277(16):13700-8 [11825898] Oncogene. 2002 May 16;21(22):3541-51 [12032856] J Clin Invest. 2002 Jun;109(12):1551-9 [12070302] J Clin Invest. 2002 Jun;109(12):1607-15 [12070308] Clin Cancer Res. 2002 Jul;8(7):2430-6 [12114449] Cancer Res. 2002 Aug 15;62(16):4690-5 [12183427] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma. AN - 68085197; 16778104 AB - The histone deacetylase inhibitor depsipeptide (FK228) has activity in patients with cutaneous or peripheral T-cell lymphoma. Electrocardiogram abnormalities, thought to be a class effect, were observed in preclinical animal studies and phase I testing and led to the incorporation of intensive cardiac monitoring in an ongoing efficacy trial. This report summarizes the cardiac monitoring of 42 patients enrolled and treated on a phase II trial with depsipeptide. Cardiac evaluations included serial electrocardiograms to evaluate T-wave, ST segment, and QT interval effects and serial serum cardiac troponin I levels and left ventricular ejection fraction (LVEF) evaluations to exclude myocardial damage. Cardiac studies from 282 cycles and 736 doses of depsipeptide included 2,051 electrocardiograms and 161 LVEF evaluations. Although T-wave flattening (grade 1) or ST segment depression (grade 2) was observed in more than half of the electrocardiograms obtained posttreatment, these electrocardiogram abnormalities were not associated with elevation of cardiac troponin I or with altered left ventricular function. No significant changes in LVEF were observed, even in 16 patients treated for >or=6 months and regardless of prior anthracycline exposure. Posttreatment electrocardiograms had a mean heart rate-corrected QT interval prolongation of 14.4 milliseconds compared with baseline. Electrolyte replacement has been instituted to mitigate potential untoward effects. The data obtained in this study show that the administration of depsipeptide is not associated with myocardial damage or impaired cardiac function. The potential effect of heart rate-corrected QT interval prolongation remains under study. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Piekarz, Richard L AU - Frye, A Robin AU - Wright, John J AU - Steinberg, Seth M AU - Liewehr, David J AU - Rosing, Douglas R AU - Sachdev, Vandana AU - Fojo, Tito AU - Bates, Susan E AD - Center for Cancer Research and Cancer Therapeutics Evaluation Program, National Cancer Institute and National Heart Lung and Blood Institute, NIH, Bethesda, Maryland 20892-1903, USA. rpiekarz@nih.gov Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 3762 EP - 3773 VL - 12 IS - 12 SN - 1078-0432, 1078-0432 KW - Antibiotics, Antineoplastic KW - 0 KW - Depsipeptides KW - romidepsin KW - CX3T89XQBK KW - Index Medicus KW - Myocardium -- pathology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Monitoring, Physiologic KW - Recurrence KW - Depsipeptides -- toxicity KW - Lymphoma, T-Cell -- drug therapy KW - Heart -- drug effects KW - Depsipeptides -- therapeutic use KW - Antibiotics, Antineoplastic -- toxicity KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68085197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Cardiac+studies+in+patients+treated+with+depsipeptide%2C+FK228%2C+in+a+phase+II+trial+for+T-cell+lymphoma.&rft.au=Piekarz%2C+Richard+L%3BFrye%2C+A+Robin%3BWright%2C+John+J%3BSteinberg%2C+Seth+M%3BLiewehr%2C+David+J%3BRosing%2C+Douglas+R%3BSachdev%2C+Vandana%3BFojo%2C+Tito%3BBates%2C+Susan+E&rft.aulast=Piekarz&rft.aufirst=Richard&rft.date=2006-06-15&rft.volume=63&rft.issue=7&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-11 N1 - Date created - 2006-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2006 Jun 15;12(12):3646-7 [16778090] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver. AN - 68062022; 16368122 AB - Our prior work shows that in utero arsenic exposure alone is a complete transplacental carcinogen, producing hepatocellular carcinoma in adult male offspring but not in females. In a follow-up study to potentially promote arsenic-initiated tumors, mice were exposed to arsenic (85 ppm) from gestation day 8 to 18 and then exposed to 12-O-teradecanoyl phorbol-13-acetate (TPA), a well-known tumor promoter after weaning. The dermal application of TPA (2 mug/0.1 ml acetone, twice/week for 21 weeks) after transplacental arsenic did not further increase arsenic-induced liver tumor formation in adult males but significantly increased liver tumor formation in adult females. Thus, for comparison, liver tumors and normal liver samples taken from adult male and female mice at necropsy were analyzed for aberrant gene/protein expression by microarray, real-time RT-PCR and Western blot analysis. Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice. Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers. Alterations in these gene products were associated with arsenic/TPA-induced liver tumors, regardless of sex. Thus, transplacental arsenic plus postnatal TPA exposure induced similar aberrant gene expression patterns in male and female mouse liver, which are persistent and potentially important to the mechanism of arsenic initiation of hepatocarcinogenesis. JF - Toxicology and applied pharmacology AU - Liu, Jie AU - Xie, Yaxiong AU - Merrick, B Alex AU - Shen, Jun AU - Ducharme, Danica M K AU - Collins, Jennifer AU - Diwan, Bhalchandra A AU - Logsdon, Daniel AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0-09, Research Triangle Park, NC 27709, USA. Liu6@niehs.nih.gov Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 216 EP - 223 VL - 213 IS - 3 SN - 0041-008X, 0041-008X KW - Arsenic KW - N712M78A8G KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Maternal-Fetal Exchange KW - Gene Expression Profiling KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Mice, Inbred C3H KW - Mice KW - Male KW - Female KW - Administration, Topical KW - Pregnancy KW - Tetradecanoylphorbol Acetate -- toxicity KW - Liver Neoplasms -- metabolism KW - Arsenic -- toxicity KW - Liver -- drug effects KW - Liver Neoplasms -- chemically induced KW - Liver -- metabolism KW - Tetradecanoylphorbol Acetate -- administration & dosage KW - Gene Expression Regulation -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68062022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Transplacental+arsenic+plus+postnatal+12-O-teradecanoyl+phorbol-13-acetate+exposures+associated+with+hepatocarcinogenesis+induce+similar+aberrant+gene+expression+patterns+in+male+and+female+mouse+liver.&rft.au=Liu%2C+Jie%3BXie%2C+Yaxiong%3BMerrick%2C+B+Alex%3BShen%2C+Jun%3BDucharme%2C+Danica+M+K%3BCollins%2C+Jennifer%3BDiwan%2C+Bhalchandra+A%3BLogsdon%2C+Daniel%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-06-15&rft.volume=213&rft.issue=3&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast cancer incidence in U.S. radiologic technologists. AN - 68050296; 16639729 AB - Studies of atomic bomb survivors and medically exposed populations have demonstrated an increased risk of breast cancer associated with acute or protracted, intermediate-dose or high-dose, ionizing radiation; however, the risks associated with low-dose and low-dose-rate (protracted) exposures are less certain. The authors evaluated incident breast cancer risks from 1983 to 1998 according to employment characteristics and a 4-level proxy index for cumulative radiation exposure based on 2 mail surveys among 56,436 U.S. female radiologic technologists who were certified from 1925 to 1980, adjusting for established breast cancer risk factors. During follow-up, 1050 new breast cancer diagnoses were ascertained. Compared with radiologic technologists who began working in 1970 or later, adjusted breast cancer risks for those who first worked in the 1960s, 1950s, 1940s, from 1935 to 1939, and before 1935 were 1.0 (95% confidence interval [CI], 0.8-1.2), 1.2 (95% CI, 0.9-1.6), 1.0 (95% CI, 0.7-1.5), 1.8 (95% CI, 1.0-3.2), and 2.9 (95% CI, 1.3-6.2), respectively. The risk rose with the number of years worked before 1940 (P value for trend = .002) and was elevated significantly among those who began working before age 17 years (relative risk, 2.6; 95% CI, 1.3-5.1; 10 women) but was not related to the total years worked in the 1940s or later. Compared with technologists who had a Level 1 (minimal) proxy index for cumulative radiation exposure, breast cancer risks were 1.0 (95% CI, 0.9-1.2), 1.0 (95% CI, 0.7-1.3), and 1.5 (95% CI, 1.0-2.2), respectively, for technologists who had Level 2, Level 3, and Level 4 (highest) exposure. Breast cancer risk was elevated significantly in female radiologic technologists who experienced daily low-dose radiation exposures over several years that potentially resulted in appreciable cumulative exposure. The increased risk for total years worked before 1940, but not later, was consistent with decreasing occupational radiation exposures, improvements in radiation technology, and more stringent radiation protection standards over time. Copyright 2006 American Cancer Society. JF - Cancer AU - Doody, Michele Morin AU - Freedman, D Michal AU - Alexander, Bruce H AU - Hauptmann, Michael AU - Miller, Jeremy S AU - Rao, R Sowmya AU - Mabuchi, Kiyohiko AU - Ron, Elaine AU - Sigurdson, Alice J AU - Linet, Martha S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-7238, USA. doodym@mail.nih.gov Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 2707 EP - 2715 VL - 106 IS - 12 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Retrospective Studies KW - Incidence KW - Confidence Intervals KW - Middle Aged KW - Radiography KW - Dose-Response Relationship, Radiation KW - United States -- epidemiology KW - Female KW - Proportional Hazards Models KW - Breast Neoplasms -- diagnostic imaging KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Breast Neoplasms -- etiology KW - Technology, Radiologic -- manpower KW - Occupational Exposure -- adverse effects KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68050296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Breast+cancer+incidence+in+U.S.+radiologic+technologists.&rft.au=Doody%2C+Michele+Morin%3BFreedman%2C+D+Michal%3BAlexander%2C+Bruce+H%3BHauptmann%2C+Michael%3BMiller%2C+Jeremy+S%3BRao%2C+R+Sowmya%3BMabuchi%2C+Kiyohiko%3BRon%2C+Elaine%3BSigurdson%2C+Alice+J%3BLinet%2C+Martha+S&rft.aulast=Doody&rft.aufirst=Michele&rft.date=2006-06-15&rft.volume=106&rft.issue=12&rft.spage=2707&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma. AN - 68039447; 16507779 AB - Interleukin-12 (IL-12) enhances Th1-type T-cell responses and exerts antiangiogenic effects. We initiated a phase 1 pilot study of IL-12 in 32 patients with acquired immunodeficiency syndrome (AIDS)-related Kaposi sarcoma (KS) whose KS was progressing while on antiretroviral therapy. Fifteen patients had poor prognosis T(1)S(1) disease. IL-12 was administered subcutaneously twice weekly at doses from 100 to 625 ng/kg. The maximum tolerated dose was 500 ng/kg, and the principal toxicities were flulike symptoms, transaminase or bilirubin elevations, neutropenia, hemolytic anemia, and depression. No tumor responses were seen at the lowest dose (100 ng/kg), but 17 of 24 evaluable patients at the higher doses had partial or complete responses (response rate, 71%; 95% confidence interval, 48%-89%). Only 3 of 17 patients had a change in antiretroviral therapy before responding, and there were no significant differences between responders and nonresponders with regard to changes in CD4 counts or viral loads. Patients had increases in their serum IL-12, interferon-gamma, and inducible protein-10 (IP-10) after the first dose, and increases above baseline persisted after week 4. These results provide preliminary evidence that IL-12 has substantial activity against AIDS-related KS with acceptable toxicity and warrants further investigation for this indication. JF - Blood AU - Little, Richard F AU - Pluda, James M AU - Wyvill, Kathleen M AU - Rodriguez-Chavez, Isaac R AU - Tosato, Giovanna AU - Catanzaro, Andrew T AU - Steinberg, Seth M AU - Yarchoan, Robert AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1868, USA. Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 4650 EP - 4657 VL - 107 IS - 12 SN - 0006-4971, 0006-4971 KW - Anti-Retroviral Agents KW - 0 KW - CXCL10 protein, human KW - Chemokine CXCL10 KW - Chemokines, CXC KW - Interleukin-12 KW - 187348-17-0 KW - Interferon-gamma KW - 82115-62-6 KW - Transaminases KW - EC 2.6.1.- KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Depression -- blood KW - Pilot Projects KW - Influenza, Human -- blood KW - Anemia, Hemolytic -- blood KW - CD4 Lymphocyte Count KW - Chemokines, CXC -- blood KW - Viral Load KW - Transaminases -- blood KW - Anemia, Hemolytic -- chemically induced KW - Adult KW - Injections, Subcutaneous KW - Influenza, Human -- chemically induced KW - Middle Aged KW - Maximum Tolerated Dose KW - Interferon-gamma -- blood KW - Depression -- chemically induced KW - Male KW - Female KW - Remission Induction KW - Anti-Retroviral Agents -- administration & dosage KW - Sarcoma, Kaposi -- drug therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Interleukin-12 -- administration & dosage KW - Acquired Immunodeficiency Syndrome -- blood KW - Sarcoma, Kaposi -- blood KW - Interleukin-12 -- adverse effects KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Interleukin-12 -- blood KW - Sarcoma, Kaposi -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68039447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Commentary+on+eyler+and+jeste%3A+practical+issues+in+consent+capacity+and+mental+disorders&rft.au=Shore%2C+David%3BShell%2C+Pamela+Hayes%3BWishnoff%2C+Christine+Moretto&rft.aulast=Shore&rft.aufirst=David&rft.date=2006-07-01&rft.volume=24&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.690 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Jun;17(6):1876-83 [10561228] J Exp Med. 1998 Jul 20;188(2):405-8 [9670053] Virology. 2000 Jan 5;266(1):17-25 [10612656] Mod Pathol. 2000 Feb;13(2):180-5 [10697276] N Engl J Med. 2000 Apr 6;342(14):1027-38 [10749966] Clin Cancer Res. 2000 May;6(5):1678-92 [10815886] AIDS. 2000 May 26;14(8):987-93 [10853980] J Clin Oncol. 2000 Jul;18(13):2593-602 [10893291] J Infect Dis. 2000 Oct;182(4):1070-6 [10979901] Cancer Res. 2000 Sep 1;60(17):4873-80 [10987301] J Infect Dis. 2001 Apr 1;183(7):1116-20 [11237839] Gynecol Oncol. 2001 Jul;82(1):7-10 [11426954] Blood. 2002 Jan 1;99(1):67-74 [11756154] AIDS. 2002 May 24;16(8):1147-54 [12004273] Nat Rev Cancer. 2002 May;2(5):373-82 [12044013] Clin Cancer Res. 2002 Dec;8(12):3686-95 [12473577] Mol Psychiatry. 2002;7(10):1107-14 [12476326] J Infect Dis. 2003 Jan 1;187(1):149-53 [12508160] Clin Cancer Res. 2003 Jan;9(1):76-83 [12538454] Cancer Cell. 2003 Jan;3(1):23-36 [12559173] J Clin Oncol. 2003 Aug 1;21(15):2876-82 [12885804] J Clin Oncol. 2004 Feb 1;22(3):399-402 [14752065] Gynecol Oncol. 2004 Mar;92(3):957-64 [14984966] Clin Cancer Res. 2004 Aug 15;10(16):5432-8 [15328181] N Engl J Med. 1983 May 5;308(18):1071-6 [6835320] Ann Intern Med. 1984 May;100(5):671-6 [6712031] J Biol Response Mod. 1985 Aug;4(4):358-64 [3928825] Science. 1989 Jan 13;243(4888):223-6 [2643161] J Exp Med. 1989 Sep 1;170(3):827-45 [2504877] J Clin Oncol. 1989 Sep;7(9):1201-7 [2671281] Proc Natl Acad Sci U S A. 1990 Sep;87(17):6808-12 [2204066] Int J Cancer. 1991 Mar 12;47(5):692-6 [2004849] J Exp Med. 1991 Apr 1;173(4):869-79 [1672545] Immunol Today. 1991 Oct;12(10):346-8 [1683536] J Exp Med. 1992 Mar 1;175(3):779-88 [1346796] J Immunol. 1993 Sep 1;151(5):2444-52 [8103066] J Exp Med. 1993 Oct 1;178(4):1223-30 [8104230] Nat Clin Pract Oncol. 2005 Aug;2(8):406-15; quiz 423 [16130937] Science. 1993 Dec 10;262(5140):1721-4 [7903123] Clin Cancer Res. 1997 Mar;3(3):409-17 [9815699] Blood. 1999 Jun 15;93(12):4044-58 [10361101] Blood. 1999 Aug 1;94(3):902-8 [10419880] J Clin Oncol. 2005 Feb 10;23(5):990-8 [15598977] J Leukoc Biol. 1994 Feb;55(2):280-8 [7905508] J Immunol. 1994 Aug 15;153(4):1697-706 [7913943] Science. 1994 Dec 16;266(5192):1865-9 [7997879] AIDS. 1994 Dec;8(12):1695-9 [7534090] N Engl J Med. 1995 May 4;332(18):1181-5 [7700310] Blood. 1995 Apr 15;85(8):2114-23 [7718882] J Natl Cancer Inst. 1995 Apr 19;87(8):581-6 [7538593] J Exp Med. 1995 Jul 1;182(1):155-62 [7540647] Blood. 1996 May 1;87(9):3877-82 [8611715] J Leukoc Biol. 1996 May;59(5):623-30 [8656046] J Infect Dis. 1996 Jul;174(1):46-53 [8656012] Science. 1996 Dec 6;274(5293):1739-44 [8939871] J Clin Oncol. 1997 Sep;15(9):3085-92 [9294471] Science. 1997 Oct 10;278(5336):290-4 [9323208] Nature. 1998 Jan 1;391(6662):86-9 [9422510] Clin Cancer Res. 1998 May;4(5):1183-91 [9607576] J Invest Dermatol. 1999 Dec;113(6):1047-53 [10594750] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Autoimmunity is Associated with Better Survival in Multiple Myeloma T2 - 11th Congress of the European Hematology Association AN - 40155707; 4308421 JF - 11th Congress of the European Hematology Association AU - Landgren, Ola AU - Pfeiffer, R M AU - Baris, D AU - Gridley, G AU - Mellemkjaer, L AU - Hemminki, K AU - Goldin, L R AU - Caporaso, N E Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Survival KW - Autoimmunity KW - Multiple myeloma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40155707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Congress+of+the+European+Hematology+Association&rft.atitle=Autoimmunity+is+Associated+with+Better+Survival+in+Multiple+Myeloma&rft.au=Landgren%2C+Ola%3BPfeiffer%2C+R+M%3BBaris%2C+D%3BGridley%2C+G%3BMellemkjaer%2C+L%3BHemminki%2C+K%3BGoldin%2C+L+R%3BCaporaso%2C+N+E&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Congress+of+the+European+Hematology+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/welcome.do?type=public&congress =6_06EHA LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Personal History of Repeated Pneumonia is Associated with Increased Risk of Multiple Myeloma T2 - 11th Congress of the European Hematology Association AN - 40141505; 4308436 JF - 11th Congress of the European Hematology Association AU - Landgren, Ola AU - Rapkin, J AU - Mellemkjaer, L AU - Gridley, G AU - Goldin, L R AU - Engels, E A Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Historical account KW - Pneumonia KW - Multiple myeloma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Congress+of+the+European+Hematology+Association&rft.atitle=Personal+History+of+Repeated+Pneumonia+is+Associated+with+Increased+Risk+of+Multiple+Myeloma&rft.au=Landgren%2C+Ola%3BRapkin%2C+J%3BMellemkjaer%2C+L%3BGridley%2C+G%3BGoldin%2C+L+R%3BEngels%2C+E+A&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Congress+of+the+European+Hematology+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/welcome.do?type=public&congress =6_06EHA LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fludarabine and Cyclophosphamid (FC) Versus Cyclophosphamide, Vincristine and Prednisone (CVP) as First Line Treatment in Chronic Lymphocytic Leukaemia (CLL) T2 - 11th Congress of the European Hematology Association AN - 40140969; 4308796 JF - 11th Congress of the European Hematology Association AU - Abdelhamid, Thoraya AU - Al-lahloby, Nasr AU - Kamel, Azza AU - Elsharkawy, Nahla AU - Zaher, Amr AU - Francis, Nevein Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Chronic lymphatic leukemia KW - Vincristine KW - Cyclophosphamide KW - Prednisone KW - Fc KW - Fludarabine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40140969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Congress+of+the+European+Hematology+Association&rft.atitle=Fludarabine+and+Cyclophosphamid+%28FC%29+Versus+Cyclophosphamide%2C+Vincristine+and+Prednisone+%28CVP%29+as+First+Line+Treatment+in+Chronic+Lymphocytic+Leukaemia+%28CLL%29&rft.au=Abdelhamid%2C+Thoraya%3BAl-lahloby%2C+Nasr%3BKamel%2C+Azza%3BElsharkawy%2C+Nahla%3BZaher%2C+Amr%3BFrancis%2C+Nevein&rft.aulast=Abdelhamid&rft.aufirst=Thoraya&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Congress+of+the+European+Hematology+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/welcome.do?type=public&congress =6_06EHA LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Study of Candida Bloodstream Infections: Clinical Characteristics and Factors Influencing the Mortality in Hospitalized Adult and Pediatric Cancer Patients T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40121302; 4258976 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Velasco, E AU - Schirmer, M AU - Martins, C.A.S. Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Infection KW - Mortality KW - Cancer KW - Pediatrics KW - Comparative studies KW - Candida KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Comparative+Study+of+Candida+Bloodstream+Infections%3A+Clinical+Characteristics+and+Factors+Influencing+the+Mortality+in+Hospitalized+Adult+and+Pediatric+Cancer+Patients&rft.au=Velasco%2C+E%3BSchirmer%2C+M%3BMartins%2C+C.A.S.&rft.aulast=Velasco&rft.aufirst=E&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Occurence of Multidrug-resistant Salmonella sp. in Edible Freshwater Fish in Kolkata, India T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40112665; 4257877 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Chakraborty, S AU - Roychudhury, S AU - Biswas, S AU - Lahiri, P AU - Das, S Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - India KW - Freshwater fish KW - Freshwater environments KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40112665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Occurence+of+Multidrug-resistant+Salmonella+sp.+in+Edible+Freshwater+Fish+in+Kolkata%2C+India&rft.au=Chakraborty%2C+S%3BRoychudhury%2C+S%3BBiswas%2C+S%3BLahiri%2C+P%3BDas%2C+S&rft.aulast=Chakraborty&rft.aufirst=S&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Bumpy Road to an AIDS Vaccine T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40086587; 4259096 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Johnston, M Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Vaccines KW - Acquired immune deficiency syndrome KW - Highways KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40086587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=The+Bumpy+Road+to+an+AIDS+Vaccine&rft.au=Johnston%2C+M&rft.aulast=Johnston&rft.aufirst=M&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TAACF:Tuberculosis Antimicrobial Acquisition and Coordinating Facility T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40084930; 4258406 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Plumley, K AU - Laughon, B AU - Goldman, R AU - Secrist, J AU - Franzblau, S AU - Krahenbuhl, J AU - Rouse, D AU - Lenaerts, A AU - Orme, I Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Tuberculosis KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40084930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=TAACF%3ATuberculosis+Antimicrobial+Acquisition+and+Coordinating+Facility&rft.au=Plumley%2C+K%3BLaughon%2C+B%3BGoldman%2C+R%3BSecrist%2C+J%3BFranzblau%2C+S%3BKrahenbuhl%2C+J%3BRouse%2C+D%3BLenaerts%2C+A%3BOrme%2C+I&rft.aulast=Plumley&rft.aufirst=K&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prospective Study of the Epidemiology and Outcome of Fungal Bloodstream Infections in Hospitalized Hematologic Patients with Malignancies T2 - 12th International Congress on Infectious Diseases (ICID 12) AN - 40080186; 4258190 JF - 12th International Congress on Infectious Diseases (ICID 12) AU - Velasco, E AU - Bigni, R AU - Schirmer, M AU - Martins, C.A.S. Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 KW - Infection KW - Epidemiology KW - Malignancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40080186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.atitle=Prospective+Study+of+the+Epidemiology+and+Outcome+of+Fungal+Bloodstream+Infections+in+Hospitalized+Hematologic+Patients+with+Malignancies&rft.au=Velasco%2C+E%3BBigni%2C+R%3BSchirmer%2C+M%3BMartins%2C+C.A.S.&rft.aulast=Velasco&rft.aufirst=E&rft.date=2006-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Congress+on+Infectious+Diseases+%28ICID+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isid.org/12th_icid/Downloads/12th_ICID_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Comparison of Two Fluid-Management Strategies in Acute Lung Injury AN - 223923543; 16714767 AB - Background Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion. Methods In a randomized study, we compared a conservative and a liberal strategy of fluid management using explicit protocols applied for seven days in 1000 patients with acute lung injury. The primary end point was death at 60 days. Secondary end points included the number of ventilator-free days and organ-failure-free days and measures of lung physiology. Results The rate of death at 60 days was 25.5 percent in the conservative-strategy group and 28.4 percent in the liberal-strategy group (P=0.30; 95 percent confidence interval for the difference, -2.6 to 8.4 percent). The mean (±SE) cumulative fluid balance during the first seven days was -136±491 ml in the conservative-strategy group and 6992±502 ml in the liberal-strategy group (P<0.001). As compared with the liberal strategy, the conservative strategy improved the oxygenation index ([mean airway pressure×the ratio of the fraction of inspired oxygen to the partial pressure of arterial oxygen]×100) and the lung injury score and increased the number of ventilator-free days (14.6±0.5 vs. 12.1±0.5, P<0.001) and days not spent in the intensive care unit (13.4±0.4 vs. 11.2±0.4, P<0.001) during the first 28 days but did not increase the incidence or prevalence of shock during the study or the use of dialysis during the first 60 days (10 percent vs. 14 percent, P=0.06). Conclusions Although there was no significant difference in the primary outcome of 60-day mortality, the conservative strategy of fluid management improved lung function and shortened the duration of mechanical ventilation and intensive care without increasing nonpulmonary-organ failures. These results support the use of a conservative strategy of fluid management in patients with acute lung injury. (ClinicalTrials.gov number, NCT00281268 .) JF - The New England Journal of Medicine AU - Wiedemann, Herbert P AU - Wheeler, Arthur P AU - Bernard, Gordon R AU - B Taylor Thompson AU - et al Y1 - 2006/06/15/ PY - 2006 DA - 2006 Jun 15 SP - 2564 EP - 75 CY - Boston PB - Massachusetts Medical Society VL - 354 IS - 24 SN - 00284793 KW - Medical Sciences KW - Diuretics KW - Furosemide KW - Lungs KW - Injuries KW - Respiratory distress syndrome KW - Mortality KW - Proteins KW - Respiratory Function Tests KW - Respiratory Distress Syndrome, Adult -- mortality KW - Blood Pressure KW - Humans KW - Hemodynamics KW - Furosemide -- therapeutic use KW - Fluid Therapy -- adverse effects KW - Respiration, Artificial -- utilization KW - Intensive Care Units -- utilization KW - Diuretics -- therapeutic use KW - Ethnic Groups KW - Treatment Outcome KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Middle Aged KW - Water-Electrolyte Balance KW - Female KW - Male KW - Survival Analysis KW - Fluid Therapy -- methods KW - Respiratory Distress Syndrome, Adult -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223923543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Comparison+of+Two+Fluid-Management+Strategies+in+Acute+Lung+Injury&rft.au=Wiedemann%2C+Herbert+P%3BWheeler%2C+Arthur+P%3BBernard%2C+Gordon+R%3BB+Taylor+Thompson%3Bet+al&rft.aulast=Wiedemann&rft.aufirst=Herbert&rft.date=2006-06-15&rft.volume=354&rft.issue=24&rft.spage=2564&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2006 Massachusetts Medical Society. All rights reserved. N1 - Document feature - Tables; Charts; Graphs; References N1 - Last updated - 2014-05-02 N1 - CODEN - NEJMAG ER - TY - JOUR T1 - Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. AN - 68083524; 16775146 AB - The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their reinforcing effects. However, preclinical studies have shown that with repeated drug exposure neutral stimuli paired with the drug (conditioned stimuli) start to increase dopamine by themselves, which is an effect that could underlie drug-seeking behavior. Here we test whether dopamine increases occur to conditioned stimuli in human subjects addicted to cocaine and whether this is associated with drug craving. We tested eighteen cocaine-addicted subjects using positron emission tomography and [11C]raclopride (dopamine D2 receptor radioligand sensitive to competition with endogenous dopamine). We measured changes in dopamine by comparing the specific binding of [11C]raclopride when subjects watched a neutral video (nature scenes) versus when they watched a cocaine-cue video (scenes of subjects smoking cocaine). The specific binding of [11C]raclopride in dorsal (caudate and putamen) but not in ventral striatum (in which nucleus accumbens is located) was significantly reduced in the cocaine-cue condition and the magnitude of this reduction correlated with self-reports of craving. Moreover, subjects with the highest scores on measures of withdrawal symptoms and of addiction severity that have been shown to predict treatment outcomes, had the largest dopamine changes in dorsal striatum. This provides evidence that dopamine in the dorsal striatum (region implicated in habit learning and in action initiation) is involved with craving and is a fundamental component of addiction. Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Logan, Jean AU - Childress, Anna-Rose AU - Jayne, Millard AU - Ma, Yeming AU - Wong, Christopher AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA. nvolkow@nida.nih.gov Y1 - 2006/06/14/ PY - 2006 DA - 2006 Jun 14 SP - 6583 EP - 6588 VL - 26 IS - 24 KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Raclopride KW - 430K3SOZ7G KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Brain Mapping KW - Reinforcement Schedule KW - Positron-Emission Tomography KW - Humans KW - Adult KW - Middle Aged KW - Dopamine Antagonists -- pharmacokinetics KW - Raclopride -- pharmacokinetics KW - Male KW - Female KW - Corpus Striatum -- diagnostic imaging KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Corpus Striatum -- metabolism KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68083524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Cocaine+cues+and+dopamine+in+dorsal+striatum%3A+mechanism+of+craving+in+cocaine+addiction.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BChildress%2C+Anna-Rose%3BJayne%2C+Millard%3BMa%2C+Yeming%3BWong%2C+Christopher&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2006-06-14&rft.volume=26&rft.issue=24&rft.spage=6583&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Neurosci. 2006 Jul 5;26(27):table of contents N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure. AN - 68076500; 16754864 AB - The loss of TGFbeta or its downstream mediator, Smad3, key players in tissue repair, accelerates closure of incisional wounds in mice. In contrast, we now report that excisional ear wounds in mice lacking Smad3 enlarge compared with wild-type controls resulting from changes in extracellular matrix molecules, which alter the mechanotransduction properties of these wounds. Specifically, levels of elastin and glycosoaminoglycans are increased, collagen fibers are more compactly organized, and matrix modulators like integrins, TGFbeta1, and matrix metalloproteinases (MMPs) are altered both basally and after wounding in Smad3 knockout mice. Mechanical testing of dorsal skin correlates these changes in matrix composition with functional parameters, specifically an increased elastic modulus, suggesting an imbalance of tissue forces. We propose that the altered mechanical elastic properties translate into a persistent retractile force that is opposed by decreased wound contractile forces contributing to the enlarging ear wound in Smad3 knockout mice. These studies highlight a previously undescribed role for Smad3 in the mechanotransduction of matrix unsupported ear wound closure. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Arany, Praveen R AU - Flanders, Kathleen C AU - Kobayashi, Tetsu AU - Kuo, Catherine K AU - Stuelten, Christina AU - Desai, Kartiki V AU - Tuan, Rocky AU - Rennard, Stephen I AU - Roberts, Anita B AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/06/13/ PY - 2006 DA - 2006 Jun 13 SP - 9250 EP - 9255 VL - 103 IS - 24 SN - 0027-8424, 0027-8424 KW - Biomarkers KW - 0 KW - Integrin alphaVbeta3 KW - Integrins KW - Receptors, Vitronectin KW - Smad3 Protein KW - Smad3 protein, mouse KW - integrin alphaVbeta5 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Ear, External -- metabolism KW - Fibroblasts -- cytology KW - Mice KW - Protein-Tyrosine Kinases -- metabolism KW - Fibroblasts -- metabolism KW - Mice, Knockout KW - Ear, External -- pathology KW - Cells, Cultured KW - Stress, Mechanical KW - Integrin alphaVbeta3 -- metabolism KW - Mice, Inbred C57BL KW - Biomarkers -- metabolism KW - Integrins -- metabolism KW - Receptors, Vitronectin -- metabolism KW - Bone Marrow Transplantation KW - Elasticity KW - Extracellular Matrix -- chemistry KW - Extracellular Matrix -- metabolism KW - Wound Healing KW - Skin -- metabolism KW - Smad3 Protein -- metabolism KW - Skin -- pathology KW - Mechanotransduction, Cellular -- physiology KW - Smad3 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68076500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Smad3+deficiency+alters+key+structural+elements+of+the+extracellular+matrix+and+mechanotransduction+of+wound+closure.&rft.au=Arany%2C+Praveen+R%3BFlanders%2C+Kathleen+C%3BKobayashi%2C+Tetsu%3BKuo%2C+Catherine+K%3BStuelten%2C+Christina%3BDesai%2C+Kartiki+V%3BTuan%2C+Rocky%3BRennard%2C+Stephen+I%3BRoberts%2C+Anita+B&rft.aulast=Arany&rft.aufirst=Praveen&rft.date=2006-06-13&rft.volume=103&rft.issue=24&rft.spage=9250&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-11 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Cell Biol. 1999 Sep;1(5):260-6 [10559937] Invasion Metastasis. 1985;5(4):185-92 [4008191] Int J Mol Med. 2000 Oct;6(4):391-407 [10998429] Matrix Biol. 2000 Nov;19(6):471-80 [11068201] J Cell Biol. 2001 Apr 2;153(1):35-46 [11285272] Proc Natl Acad Sci U S A. 2001 May 22;98(11):6180-5 [11353845] J Biomech. 2001 Nov;34(11):1483-90 [11672723] Nature. 2002 Jan 10;415(6868):171-5 [11805835] Nat Rev Mol Cell Biol. 2002 May;3(5):349-63 [11988769] J Cell Biol. 2002 Jun 10;157(6):1083-91 [12058022] Dev Dyn. 2003 Feb;226(2):377-87 [12557216] Nat Cell Biol. 2003 Sep;5(9):803-11 [12942086] Tissue Eng. 2003 Aug;9(4):567-77 [13678436] Am J Pathol. 2003 Dec;163(6):2247-57 [14633599] Ann Med. 2003;35(8):564-77 [14708967] J Biol Chem. 2004 Mar 26;279(13):12001-4 [14960578] Crit Rev Oncol Hematol. 2004 Mar;49(3):235-44 [15036263] Genome Biol. 2004;5(6):228 [15186486] J Invest Dermatol. 2004 Jul;123(1):229-36 [15191565] Am J Pathol. 2004 Jul;165(1):203-17 [15215176] Cornea. 2004 Jul;23(5):503-7 [15220736] Wound Repair Regen. 2004 May-Jun;12(3):320-6 [15225210] Wound Repair Regen. 2004 Jul-Aug;12(4):461-70 [15260812] J Immunol. 2004 Aug 1;173(3):2099-108 [15265946] Int J Dev Biol. 2004;48(5-6):509-17 [15349825] Adv Cancer Res. 1972;16:181-234 [4563044] N Engl J Med. 1986 Dec 25;315(26):1650-9 [3537791] Cell. 1987 Apr 10;49(1):1-4 [3030562] J Cell Biol. 1987 Sep;105(3):1463-9 [2888772] Mol Cell Biol. 1994 Jan;14(1):147-55 [7505391] J Cell Physiol. 1994 Apr;159(1):161-75 [8138584] J Biol Chem. 1995 Jul 21;270(29):17437-41 [7615549] Ciba Found Symp. 1995;192:321-35; discussion 335-7 [8575265] Br J Dermatol. 1996 Jul;135(1):46-51 [8776358] Proc Soc Exp Biol Med. 1997 Feb;214(2):123-31 [9034129] Clin Immunol Immunopathol. 1998 Jul;88(1):35-45 [9683548] Am J Pathol. 1999 Mar;154(3):871-82 [10079265] Mech Ageing Dev. 1999 Jan 15;106(3):241-60 [10100153] Clin Immunol. 1999 Sep;92(3):300-10 [10479535] J Appl Physiol (1985). 2005 Feb;98(2):672-9 [15448123] Physiology (Bethesda). 2005 Feb;20:43-53 [15653839] Wound Repair Regen. 2005 Jan-Feb;13(1):7-12 [15659031] Circ Res. 2005 Apr 29;96(8):904-12 [15790953] J Biol Chem. 2005 Jun 3;280(22):21570-6 [15788410] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11571-2 [16091458] Cancer Cell. 2005 Sep;8(3):241-54 [16169468] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18813-8 [16354837] Wound Repair Regen. 2000 May-Jun;8(3):179-91 [10886809] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reexamination of the cysteine residues in glucocerebrosidase. AN - 68036526; 16712845 AB - Glucocerebrosidase, the deficient enzyme in Gaucher disease, catalyzes the cleavage of the beta-glycosidic linkage of glucosylceramide. A previous study on the enzyme identified three disulfide bridges and a single sulfhydryl [Lee, Y., Kinoshita, H., Radke, G., Weiler, S., Barranger, J.A. and Tomich, J.M. (1995) Position of the sulfhydryl group and the disulfide bonds of human glucocerebrosidase. J. Protein Chem. 14(3), 127-137] but recent publication of the X-ray structure identifies only two disulfide bridges with three free sulfhydryls [Dvir, H., Harel, M., McCarthy, A.A., Toker, L., Silman, I., Futerman, A.H. and Sussman, J.L. (2003) X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. EMBO. 4(7), 704-709]. Using chemical modifications, acid cleavage and enzymatic digestion methods, we report that three free sulfhydryls exist and that the remaining four cysteines form two disulfide bonds located within the first 25 amino-terminal residues, supporting the X-ray structure. JF - FEBS letters AU - Moharram, Ramy AU - Maynard, Dawn AU - Wang, Eric S AU - Makusky, Anthony AU - Murray, Gary J AU - Martin, Brian M AD - Unit on Molecular Structures, Laboratory of Neurotoxicology, NIMH, NIH, DHHS, Bethesda, MD 20892, USA. moharrar@mail.nih.gov Y1 - 2006/06/12/ PY - 2006 DA - 2006 Jun 12 SP - 3391 EP - 3394 VL - 580 IS - 14 SN - 0014-5793, 0014-5793 KW - Recombinant Proteins KW - 0 KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Molecular Sequence Data KW - Mass Spectrometry -- methods KW - Amino Acid Sequence KW - Recombinant Proteins -- chemistry KW - Chromatography, High Pressure Liquid KW - Cysteine -- chemistry KW - Glucosylceramidase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68036526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Reexamination+of+the+cysteine+residues+in+glucocerebrosidase.&rft.au=Moharram%2C+Ramy%3BMaynard%2C+Dawn%3BWang%2C+Eric+S%3BMakusky%2C+Anthony%3BMurray%2C+Gary+J%3BMartin%2C+Brian+M&rft.aulast=Moharram&rft.aufirst=Ramy&rft.date=2006-06-12&rft.volume=580&rft.issue=14&rft.spage=3391&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-27 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Thyroid and Brain Development, in Developed and Developing Countries T2 - 10th International Child Neurology Congress AN - 39768356; 4098097 JF - 10th International Child Neurology Congress AU - Nelson, Karin B Y1 - 2006/06/11/ PY - 2006 DA - 2006 Jun 11 KW - Brain KW - Developing countries KW - Thyroid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Child+Neurology+Congress&rft.atitle=Thyroid+and+Brain+Development%2C+in+Developed+and+Developing+Countries&rft.au=Nelson%2C+Karin+B&rft.aulast=Nelson&rft.aufirst=Karin&rft.date=2006-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Child+Neurology+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.icnc2006.com/scientific_programme/detailed_programme.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Misclassification of Race, Hispanic Ethnicity, and Birthplace Information on Patient Survival using the Seer Data T2 - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AN - 40187247; 4324947 JF - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AU - Clegg, L X AU - Reichman, M E AU - Hankey, B F AU - Edwards, B K Y1 - 2006/06/10/ PY - 2006 DA - 2006 Jun 10 KW - North America KW - Oncology KW - Socio-economic aspects KW - Recruitment KW - Screening KW - Elderly KW - Quality assurance KW - Remote sensing KW - Legislation KW - Prevention KW - Geographic information systems KW - Rehabilitation KW - Ethnic groups KW - Training KW - Geriatrics KW - Epidemiology KW - Socioeconomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40187247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.atitle=Effects+of+Misclassification+of+Race%2C+Hispanic+Ethnicity%2C+and+Birthplace+Information+on+Patient+Survival+using+the+Seer+Data&rft.au=Clegg%2C+L+X%3BReichman%2C+M+E%3BHankey%2C+B+F%3BEdwards%2C+B+K&rft.aulast=Clegg&rft.aufirst=L&rft.date=2006-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.naaccr.org/index.asp?Col_SectionKey=9&Col_ContentID=396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changing Geographies Dealing with County and Census Tract Boundary Changes T2 - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AN - 40187167; 4324919 JF - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AU - Stinchcomb, D G AU - Pickle, L W AU - Miller, B A AU - Cucinelli, J AU - Gibson, J T AU - Scoppa, S Y1 - 2006/06/10/ PY - 2006 DA - 2006 Jun 10 KW - North America KW - Oncology KW - Socio-economic aspects KW - Recruitment KW - Screening KW - Elderly KW - Quality assurance KW - Remote sensing KW - Legislation KW - Prevention KW - Geographic information systems KW - Rehabilitation KW - Ethnic groups KW - Training KW - Geriatrics KW - Epidemiology KW - Socioeconomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40187167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.atitle=Changing+Geographies+Dealing+with+County+and+Census+Tract+Boundary+Changes&rft.au=Stinchcomb%2C+D+G%3BPickle%2C+L+W%3BMiller%2C+B+A%3BCucinelli%2C+J%3BGibson%2C+J+T%3BScoppa%2C+S&rft.aulast=Stinchcomb&rft.aufirst=D&rft.date=2006-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.naaccr.org/index.asp?Col_SectionKey=9&Col_ContentID=396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seer Registry Operations Cost Study: Results of the Feasibility Study T2 - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AN - 40182873; 4324957 JF - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AU - Garson, A AU - Scott, J AU - Aitken, S AU - Hankey, B F AU - Edwards, B K Y1 - 2006/06/10/ PY - 2006 DA - 2006 Jun 10 KW - North America KW - Oncology KW - Socio-economic aspects KW - Recruitment KW - Screening KW - Elderly KW - Quality assurance KW - Remote sensing KW - Legislation KW - Prevention KW - Geographic information systems KW - Rehabilitation KW - Ethnic groups KW - Training KW - Geriatrics KW - Epidemiology KW - Socioeconomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40182873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.atitle=Seer+Registry+Operations+Cost+Study%3A+Results+of+the+Feasibility+Study&rft.au=Garson%2C+A%3BScott%2C+J%3BAitken%2C+S%3BHankey%2C+B+F%3BEdwards%2C+B+K&rft.aulast=Garson&rft.aufirst=A&rft.date=2006-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.naaccr.org/index.asp?Col_SectionKey=9&Col_ContentID=396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are there Socioeconomic Gradients in the Quality of Data Collected by Seer Cancer Registries? T2 - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AN - 40182257; 4324959 JF - 2006 Annual Conference of the North American Association of Central Cancer Registries (NAACCR 2006) AU - Miller, B A AU - Hankey, B F Y1 - 2006/06/10/ PY - 2006 DA - 2006 Jun 10 KW - North America KW - Oncology KW - Socio-economic aspects KW - Recruitment KW - Screening KW - Elderly KW - Quality assurance KW - Remote sensing KW - Legislation KW - Prevention KW - Geographic information systems KW - Rehabilitation KW - Ethnic groups KW - Training KW - Geriatrics KW - Epidemiology KW - Socioeconomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40182257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+North+American+Association+of+Central+Cancer+Registries+%28NAACCR+2006%29&rft.atitle=Are+there+Socioeconomic+Gradients+in+the+Quality+of+Data+Collected+by+Seer+Cancer+Registries%3F&rft.au=Miller%2C+B+A%3BHankey%2C+B+F&rft.aulast=Miller&rft.aufirst=B&rft.date=2006-06-10&rft.volume=13&rft.issue=7&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fsj.cgt.7700943 L2 - http://www.naaccr.org/index.asp?Col_SectionKey=9&Col_ContentID=396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. AN - 68782055; 16759389 AB - Gene-targeted iMycEmu mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Emu, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell lymphoma (LBL) and plasmacytoma (PCT). Cell lines derived from Myc-induced neoplasms of this sort may provide a good model system for the design and testing of new approaches to prevent and treat MYC-driven B cell and plasma cell neoplasms in human beings. To test this hypothesis, we used the LBL-derived cell line, iMycEmu-1, and the newly established PCT-derived cell line, iMycEmu-2, to evaluate the growth inhibitory and death inducing potency of the cancer drug candidate, CDDO-imidazolide (CDDO-Im). Morphological features and surface marker expression of iMycEmu-2 cells were evaluated using cytological methods and FACS, respectively. mRNA expression levels of the inserted MycHis and normal Myc genes were determined by allele-specific RT-PCR and qPCR. Myc protein was detected by immunoblotting. Cell cycle progression and apoptosis were analyzed by FACS. The expression of 384 "pathway" genes was assessed with the help of Superarray cDNA macroarrays and verified, in part, by RT-PCR. Sub-micromolar concentrations of CDDO-Im caused growth arrest and apoptosis in iMycEmu-1 and iMycEmu-2 cells. CDDO-Im-dependent growth inhibition and apoptosis were associated in both cell lines with the up-regulation of 30 genes involved in apoptosis, cell cycling, NFkappaB signaling, and stress and toxicity responses. Strongly induced (> or = 10 fold) were genes encoding caspase 14, heme oxygenase 1 (Hmox1), flavin-containing monooxygenase 4 (Fmo4), and three members of the cytochrome P450 subfamily 2 of mixed-function oxygenases (Cyp2a4, Cyp2b9, Cyp2c29). CDDO-Im-dependent gene induction coincided with a decrease in Myc protein. Growth arrest and killing of neoplastic mouse B cells and plasma cells by CDDO-Im, a closely related derivative of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid, appears to be caused, in part, by drug-induced stress responses and reduction of Myc. JF - Molecular cancer AU - Han, Seong-Su AU - Peng, Liangping AU - Chung, Seung-Tae AU - DuBois, Wendy AU - Maeng, Sung-Ho AU - Shaffer, Arthur L AU - Sporn, Michael B AU - Janz, Siegfried AD - Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. hanse@mail.nih.gov Y1 - 2006/06/07/ PY - 2006 DA - 2006 Jun 07 SP - 22 VL - 5 KW - 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid KW - 0 KW - DNA, Complementary KW - Imidazolidines KW - NF-kappa B KW - Proto-Oncogene Proteins c-myc KW - Oleanolic Acid KW - 6SMK8R7TGJ KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Cell Proliferation -- drug effects KW - Animals KW - DNA, Complementary -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Cell Survival -- drug effects KW - Mice KW - Up-Regulation KW - Mice, Transgenic KW - Transcriptional Activation KW - NF-kappa B -- genetics KW - Cell Line KW - B-Lymphocytes -- drug effects KW - Plasmacytoma -- genetics KW - Plasmacytoma -- metabolism KW - B-Lymphocytes -- pathology KW - Plasmacytoma -- pathology KW - Imidazolidines -- chemistry KW - Oleanolic Acid -- analogs & derivatives KW - Proto-Oncogene Proteins c-myc -- genetics KW - Proto-Oncogene Proteins c-myc -- metabolism KW - B-Lymphocytes -- metabolism KW - Imidazolidines -- pharmacology KW - Oleanolic Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68782055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer&rft.atitle=CDDO-Imidazolide+inhibits+growth+and+survival+of+c-Myc-induced+mouse+B+cell+and+plasma+cell+neoplasms.&rft.au=Han%2C+Seong-Su%3BPeng%2C+Liangping%3BChung%2C+Seung-Tae%3BDuBois%2C+Wendy%3BMaeng%2C+Sung-Ho%3BShaffer%2C+Arthur+L%3BSporn%2C+Michael+B%3BJanz%2C+Siegfried&rft.aulast=Han&rft.aufirst=Seong-Su&rft.date=2006-06-07&rft.volume=5&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer&rft.issn=01654608&rft_id=info:doi/10.1016%2Fj.cancergencyto.2006.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Mar 19;279(12):11179-87 [14711815] Genes Dev. 2003 May 1;17(9):1071-7 [12730130] Mol Cell. 2003 May;11(5):1189-200 [12769844] Clin Cancer Res. 2003 Jul;9(7):2798-806 [12855660] Oncogene. 2003 Jul 31;22(31):4924-32 [12894236] Free Radic Biol Med. 2003 Aug 15;35(4):351-67 [12899938] Arthritis Res Ther. 2003;5(5):R285-91 [12932292] Curr Opin Drug Discov Devel. 2003 Jul;6(4):486-93 [12951812] Cancer Res. 2003 Sep 15;63(18):5926-39 [14522919] Leukemia. 2003 Nov;17(11):2122-9 [12931220] J Biol Chem. 2004 Jan 23;279(4):2737-46 [14576155] Mol Pharmacol. 2004 Feb;65(2):309-18 [14742672] Mol Cancer Ther. 2004 Jan;3(1):39-45 [14749474] Clin Cancer Res. 2004 Feb 15;10(4):1471-80 [14977851] Gynecol Oncol. 2004 Apr;93(1):149-54 [15047229] Nat Cell Biol. 2004 Apr;6(4):308-18 [15048125] Nat Cell Biol. 2004 Apr;6(4):288-9 [15057241] Blood. 2004 Apr 15;103(8):3158-66 [15070698] Leukemia. 2004 May;18(5):948-52 [14990979] J Cell Physiol. 2004 Jul;200(1):82-8 [15137060] J Mol Cell Cardiol. 2004 Jun;36(6):821-30 [15158123] J Clin Invest. 2004 Jun;113(12):1763-73 [15199411] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90 [15150404] J Invest Dermatol. 2004 Aug;123(2):380-7 [15245439] Biochemistry. 2004 Aug 17;43(32):10560-9 [15301553] Immunity. 2004 Jul;21(1):81-93 [15345222] J Med Chem. 2004 Sep 23;47(20):4923-32 [15369396] Cancer Res. 2004 Oct 15;64(20):7570-8 [15492284] Nature. 1985 Dec 12-18;318(6046):533-8 [3906410] J Exp Med. 1995 Mar 1;181(3):1169-77 [7869034] Cancer Res. 1999 Jan 15;59(2):336-41 [9927043] Cancer Res. 2004 Nov 1;64(21):7927-35 [15520199] Mol Carcinog. 2005 Jan;42(1):40-52 [15547921] J Pharmacol Exp Ther. 2005 Mar;312(3):884-90 [15537824] Cancer Res. 2005 Feb 15;65(4):1306-15 [15735016] Nat Rev Mol Cell Biol. 2005 Aug;6(8):635-45 [16064138] Cancer Res. 2005 Sep 1;65(17):7644-52 [16140930] Mol Cancer. 2005;4:40 [16277667] J Pathol. 2006 May;209(1):44-55 [16482495] Cell Growth Differ. 2000 May;11(5):261-7 [10845427] Immunity. 2000 Aug;13(2):199-212 [10981963] Cold Spring Harb Symp Quant Biol. 1999;64:71-8 [11232339] Mol Pharmacol. 2001 May;59(5):1094-9 [11306692] Bioorg Med Chem Lett. 2002 Apr 8;12(7):1027-30 [11909709] J Biol Chem. 2002 May 10;277(19):16448-55 [11880365] Blood. 2002 Jul 1;100(1):246-58 [12070034] Toxicol Pathol. 2002 Jul-Aug;30(4):435-51 [12187936] Cancer Res. 2002 Sep 1;62(17):5027-34 [12208757] Blood. 2002 Oct 15;100(8):2965-72 [12351409] Mol Cell. 2002 Dec;10(6):1283-94 [12504005] Cancer Res. 2003 Mar 15;63(6):1371-6 [12649201] Mol Cell. 2003 May;11(5):1177-88 [12769843] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Birth weight and breast cancer risk AN - 899129478; 13759221 AB - Exploring whether the positive association between birth weight and breast cancer risk differs by other breast cancer risk factors may help inform speculation about biological mechanism. In these data, high birth weight was associated with breast cancer risk in younger and in more educated women, but was not associated overall.British Journal of Cancer (2006) 94, 1734-1737. doi:10.1038/sj.bjc.6603122 www.bjcancer.com Published online 25 April 2006 JF - British Journal of Cancer AU - Troisi, R AU - Hatch, E E AU - Titus-Ernstoff, L AU - Palmer, J R AU - Hyer, M AU - Strohsnitter, W C AU - Robboy, S J AU - Kaufman, R AU - Herbst, A AU - Adam, E AU - Hoover, R N AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA Y1 - 2006/06/05/ PY - 2006 DA - 2006 Jun 05 SP - 1734 EP - 1737 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 94 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Breast cancer KW - birth weight KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Birth+weight+and+breast+cancer+risk&rft.au=Troisi%2C+R%3BHatch%2C+E+E%3BTitus-Ernstoff%2C+L%3BPalmer%2C+J+R%3BHyer%2C+M%3BStrohsnitter%2C+W+C%3BRobboy%2C+S+J%3BKaufman%2C+R%3BHerbst%2C+A%3BAdam%2C+E%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2006-06-05&rft.volume=94&rft.issue=11&rft.spage=1734&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - birth weight; Breast cancer; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6603122 ER - TY - CPAPER T1 - The NCI 60 Human Tumor Cell Line Screen: An Information-Rich Screen Informing on Mechanisms of Toxicity T2 - 2006 Meeting of the Society for In Vitro Biology AN - 40160446; 4310361 JF - 2006 Meeting of the Society for In Vitro Biology AU - Shoemaker, Robert H Y1 - 2006/06/03/ PY - 2006 DA - 2006 Jun 03 KW - Toxicity KW - Tumor cell lines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40160446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+of+the+Society+for+In+Vitro+Biology&rft.atitle=The+NCI+60+Human+Tumor+Cell+Line+Screen%3A+An+Information-Rich+Screen+Informing+on+Mechanisms+of+Toxicity&rft.au=Shoemaker%2C+Robert+H&rft.aulast=Shoemaker&rft.aufirst=Robert&rft.date=2006-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+of+the+Society+for+In+Vitro+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.sivb.org/INVA_2006abstracts_1_49.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Fidelity In Vitro Modeling of Clinically-Defined, Chemically-Induced Organ Toxicity in Man using Adverse Effects of Oncology Drugs as Ethical Learning Sets T2 - 2006 Meeting of the Society for In Vitro Biology AN - 40159607; 4310362 JF - 2006 Meeting of the Society for In Vitro Biology AU - Parchment, Ralph E Y1 - 2006/06/03/ PY - 2006 DA - 2006 Jun 03 KW - Toxicity KW - Organs KW - Side effects KW - Drugs KW - Ethics KW - Oncology KW - Learning set UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40159607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+of+the+Society+for+In+Vitro+Biology&rft.atitle=High-Fidelity+In+Vitro+Modeling+of+Clinically-Defined%2C+Chemically-Induced+Organ+Toxicity+in+Man+using+Adverse+Effects+of+Oncology+Drugs+as+Ethical+Learning+Sets&rft.au=Parchment%2C+Ralph+E&rft.aulast=Parchment&rft.aufirst=Ralph&rft.date=2006-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+of+the+Society+for+In+Vitro+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.sivb.org/INVA_2006abstracts_1_49.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. AN - 68018881; 16571723 AB - Regulation of cell volume in response to changes in osmolarity is critical for cell function and survival. However, the molecular basis of osmosensation and regulation of cell volume are not clearly understood. We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume. Exposure of salivary gland cells and acini to hypotonicity elicited an increase in cell volume and activation of RVD. Hypotonicity also activated Ca2+ entry, which was required for subsequent RVD. Ca2+ entry was associated with a distinct nonselective cation current that was activated by 4alphaPDD and inhibited by ruthenium red, suggesting involvement of TRPV4. Consistent with this, endogenous TRPV4 was detected in cells and in the apical region of acini along AQP5. Importantly, acinar cells from mice lacking either TRPV4 or AQP5 displayed greatly reduced Ca2+ entry and loss of RVD in response to hypotonicity, although the extent of cell swelling was similar. Expression of N terminus-deleted AQP5 suppressed TRPV4 activation and RVD but not cell swelling. Furthermore, hypotonicity increased the association and surface expression of AQP5 and TRPV4. Both these effects and RVD were reduced by actin depolymerization. These data demonstrate that (i) activation of TRPV4 by hypotonicity depends on AQP5, not on cell swelling per se, and (ii) TRPV4 and AQP5 concertedly control regulatory volume decrease. These data suggest a potentially important role for TRPV4 in salivary gland function. JF - The Journal of biological chemistry AU - Liu, Xibao AU - Bandyopadhyay, Bidhan C AU - Bandyopadhyay, Bidhan AU - Nakamoto, Tetsuji AU - Singh, Brij AU - Liedtke, Wolfgang AU - Melvin, James E AU - Ambudkar, Indu AD - Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/06/02/ PY - 2006 DA - 2006 Jun 02 SP - 15485 EP - 15495 VL - 281 IS - 22 SN - 0021-9258, 0021-9258 KW - AQP5 protein, human KW - 0 KW - Aqp5 protein, mouse KW - Aqp5 protein, rat KW - Aquaporin 5 KW - Hypotonic Solutions KW - Recombinant Proteins KW - TRPV Cation Channels KW - TRPV4 protein, human KW - Trpv4 protein, mouse KW - Trpv4 protein, rat KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Osmolar Concentration KW - Animals KW - Humans KW - Mice KW - Recombinant Proteins -- genetics KW - Mice, Knockout KW - Mutagenesis KW - Calcium -- metabolism KW - Rats KW - Recombinant Proteins -- metabolism KW - Recombinant Proteins -- chemistry KW - Cell Line KW - Sequence Deletion KW - Aquaporin 5 -- chemistry KW - TRPV Cation Channels -- metabolism KW - Cell Size KW - Salivary Glands -- cytology KW - Aquaporin 5 -- genetics KW - Salivary Glands -- metabolism KW - TRPV Cation Channels -- deficiency KW - TRPV Cation Channels -- genetics KW - Aquaporin 5 -- metabolism KW - Aquaporin 5 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68018881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+role+for+AQP5+in+activation+of+TRPV4+by+hypotonicity%3A+concerted+involvement+of+AQP5+and+TRPV4+in+regulation+of+cell+volume+recovery.&rft.au=Liu%2C+Xibao%3BBandyopadhyay%2C+Bidhan+C%3BBandyopadhyay%2C+Bidhan%3BNakamoto%2C+Tetsuji%3BSingh%2C+Brij%3BLiedtke%2C+Wolfgang%3BMelvin%2C+James+E%3BAmbudkar%2C+Indu&rft.aulast=Liu&rft.aufirst=Xibao&rft.date=2006-06-02&rft.volume=281&rft.issue=22&rft.spage=15485&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Biol Chem. 2008 Feb 8;283(6):3688 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antagonistic Regulation of Escherichia coli Ribosomal RNA rrnB P1 Promoter Activity by GreA and DksA AN - 17238704; 6947545 AB - The Escherichia coli proteins DksA, GreA, and GreB are all structural homologs that bind the secondary channel of RNA polymerase (RNAP) but are thought to act at different levels of transcription. DksA, with its co-factor ppGpp, inhibits rrnB P1 transcription initiation, whereas GreA and GreB activate RNAP to cleave back-tracked RNA during elongational pausing. Here, in vivo and in vitro evidence reveals antagonistic regulation of rrnB P1 transcription initiation by Gre factors (particularly GreA) and DksA; GreA activates and DksA inhibits. DksA inhibition is epistatic to GreA activation. Both modes of regulation are ppGpp-independent in vivo but DksA inhibition requires ppGpp in vitro. Kinetic experiments and studies of rrnB P1-RNA polymerase complexes suggest that GreA mediates conformational changes at an initiation step in the absence of NTP substrates, even before DksA acts. GreA effects on rrnB P1 open complex conformation reveal a new feature of GreA distinct from its general function in elongation. Our findings support the idea that a balance of the interactions between the three secondary channel-binding proteins and RNAP can provide a new mode for regulating transcription. JF - Journal of Biological Chemistry AU - Potrykus, Katarzyna AU - Vinella, Daniel AU - Murphy, Helen AU - Szalewska-Palasz, Agnieszka AU - D'Ari, Richard AU - Cashel, Michael AD - Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892-2785 and the Institut Jacques Monod, CNRS, Universite Paris 6, Universite Paris 7, 7251, Paris, Cedex05, France Y1 - 2006/06/02/ PY - 2006 DA - 2006 Jun 02 SP - 15238 EP - 15248 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Promoters KW - rRNA KW - Elongation KW - DNA-directed RNA polymerase KW - Epistasis KW - Kinetics KW - Escherichia coli KW - Transcription initiation KW - Conformation KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17238704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Antagonistic+Regulation+of+Escherichia+coli+Ribosomal+RNA+rrnB+P1+Promoter+Activity+by+GreA+and+DksA&rft.au=Potrykus%2C+Katarzyna%3BVinella%2C+Daniel%3BMurphy%2C+Helen%3BSzalewska-Palasz%2C+Agnieszka%3BD%27Ari%2C+Richard%3BCashel%2C+Michael&rft.aulast=Potrykus&rft.aufirst=Katarzyna&rft.date=2006-06-02&rft.volume=281&rft.issue=22&rft.spage=15238&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Elongation; rRNA; Promoters; DNA-directed RNA polymerase; Kinetics; Epistasis; Conformation; Transcription initiation; Escherichia coli ER - TY - JOUR T1 - UvrB Domain 4, an Autoinhibitory Gate for Regulation of DNA Binding and ATPase Activity AN - 17231352; 6947544 AB - UvrB, a central DNA damage recognition protein in bacterial nucleotide excision repair, has weak affinity for DNA, and its ATPase activity is activated by UvrA and damaged DNA. Regulation of DNA binding and ATP hydrolysis by UvrB is poorly understood. Using atomic force microscopy and biochemical assays, we found that truncation of domain 4 of Bacillus caldotenax UvrB (UvrB Delta 4) leads to multiple changes in protein function. Protein dimerization decreases with an similar to 8-fold increase of the equilibrium dissociation constant and an increase in DNA binding. Loss of domain 4 causes the DNA binding mode of UvrB to change from dimer to monomer, and affinity increases with the apparent dissociation constants on nondamaged and damaged single-stranded DNA decreasing 22- and 14-fold, respectively. ATPase activity by UvrB Delta 4 increases 14- and 9-fold with and without single-stranded DNA, respectively, and UvrB Delta 4 supports UvrA-independent damage-specific incision by Cho on a bubble DNA substrate. We propose that other than its previously discovered role in regulating protein-protein interactions, domain 4 is an autoinhibitory domain regulating the DNA binding and ATPase activities of UvrB. JF - Journal of Biological Chemistry AU - Wang, Hong AU - DellaVecchia, Matthew J AU - Skorvaga, Milan AU - Croteau, Deborah L AU - Erie, Dorothy A AU - Van Houten, Bennett AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovakia, and the Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 Y1 - 2006/06/02/ PY - 2006 DA - 2006 Jun 02 SP - 15227 EP - 15237 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Monomers KW - DNA damage KW - Adenosinetriphosphatase KW - Nucleotide excision repair KW - atomic force microscopy KW - ATP KW - Single-stranded DNA KW - Bacillus KW - Hydrolysis KW - Protein interaction KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17231352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=UvrB+Domain+4%2C+an+Autoinhibitory+Gate+for+Regulation+of+DNA+Binding+and+ATPase+Activity&rft.au=Wang%2C+Hong%3BDellaVecchia%2C+Matthew+J%3BSkorvaga%2C+Milan%3BCroteau%2C+Deborah+L%3BErie%2C+Dorothy+A%3BVan+Houten%2C+Bennett&rft.aulast=Wang&rft.aufirst=Hong&rft.date=2006-06-02&rft.volume=281&rft.issue=22&rft.spage=15227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; DNA damage; Adenosinetriphosphatase; Nucleotide excision repair; atomic force microscopy; ATP; Single-stranded DNA; Hydrolysis; Protein interaction; Bacillus ER - TY - JOUR T1 - Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease. AN - 85392123; pmid-16511860 AB - Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine-to-serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. JF - Movement disorders : official journal of the Movement Disorder Society AU - Fung, Hon-Chung AU - Chen, Chiung-Mei AU - Hardy, John AU - Hernandez, Dena AU - Singleton, Andrew AU - Wu, Yih-Ru AD - Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 880 EP - 881 VL - 21 IS - 6 SN - 0885-3185, 0885-3185 KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Amino Acid Substitution KW - Female KW - Founder Effect KW - Gene Frequency KW - Humans KW - Male KW - Middle Aged KW - Mutation KW - *Parkinson Disease: genetics KW - *Protein-Serine-Threonine Kinases: genetics KW - Taiwan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Lack+of+G2019S+LRRK2+mutation+in+a+cohort+of+Taiwanese+with+sporadic+Parkinson%27s+disease.&rft.au=Fung%2C+Hon-Chung%3BChen%2C+Chiung-Mei%3BHardy%2C+John%3BHernandez%2C+Dena%3BSingleton%2C+Andrew%3BWu%2C+Yih-Ru&rft.aulast=Fung&rft.aufirst=Hon-Chung&rft.date=2006-06-01&rft.volume=21&rft.issue=6&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-29 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2. AN - 85294691; pmid-16763047 AB - We studied the spatial distribution, mobility, and trafficking of plasma membrane Ca2+ATPase-2 (PMCA2), a protein enriched in the hair cell apical membrane and essential for hair cell function. Using immunofluorescence, we determined that PMCA2 is enriched in the stereocilia and present at a relatively low concentration in the kinocilium and in the remaining apical membrane. Using an antibody to the extracellular domain of PMCA2 as a probe, we observed that PMCA2 diffuses laterally from the stereocilia membrane and is internalized at the apical cell border maintaining an estimated half-life of residency in the stereocilia of approximately 5-7 h. A computer simulation of our data indicates that PMCA2 has an estimated global diffusion coefficient of 0.01-0.005 microm2/s. Using a green fluorescent protein tag, we observed that PMCA2 is rapidly delivered to the apical cell border from where it diffuses to the entire stereocilia surface. Fluorescence recovery after photobleaching experiments show that approximately 60% of PMCA2 in the stereocilia exhibit high mobility with a diffusion coefficient of 0.1-0.2 microm2/s, whereas the remaining pool represents a relatively immobile fraction. These results suggest that PMCA2 molecules maintain transient interactions with other components of the stereocilia, and the mobile pool of PMCA2 mediates the exchange between the stereocilia and the removal and delivery sites at the periphery of the apical cell surface. This rapid turnover of a major stereocilia membrane protein matches the previously described rapid turnover of proteins of the stereocilia actin core, further demonstrating that these organelles undergo rapid continuous renewal. JF - The Journal of Neuroscience AU - Grati M'hamed AU - Schneider, Mark E AU - Lipkow, Karen AU - Strehler, Emanuel E AU - Wenthold, Robert J AU - Kachar Bechara AD - Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA. PY - 2006 SP - 6386 EP - 6395 VL - 26 IS - 23 SN - 0270-6474, 0270-6474 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85294691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Rapid+turnover+of+stereocilia+membrane+proteins%3A+evidence+from+the+trafficking+and+mobility+of+plasma+membrane+Ca%282%2B%29-ATPase+2.&rft.au=Grati+M%27hamed%3BSchneider%2C+Mark+E%3BLipkow%2C+Karen%3BStrehler%2C+Emanuel+E%3BWenthold%2C+Robert+J%3BKachar+Bechara&rft.aulast=Grati+M%27hamed&rft.aufirst=&rft.date=2006-06-01&rft.volume=26&rft.issue=23&rft.spage=6386&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats. AN - 68763812; 16914948 AB - The effects on learned operant behavior of agonist actions at dopamine D1-like receptors have not been fully characterized. We compared three D1-like receptor agonists (SKF 38393, SKF 77434 and SKF 82958), both alone and in combination with the D1-like receptor antagonist, SCH 23390. Binding affinities for the agonists at dopamine D1 receptors from rat striatum membranes were determined and compared with effects on behavior. Lever pressing was maintained by food reinforcement under a fixed-ratio 30-response schedule (each 30th response produced reinforcement), and the effects of the three agonists were assessed by cumulative dosing. Each drug produced dose-related reductions in response rates, with an order of potency (SKF 82958>SKF 77434>SKF 38393) that agreed with rank order of binding affinities. Antagonism of these behavioral effects by SCH 23390 was only significant for SKF 82958; surprisingly, SCH 23390 enhanced the effects of SKF 38393. For SKF 82958, the antagonism was receptor subtype-specific, as the D2-like receptor antagonist spiperone was ineffective. The nonselective serotonergic antagonist metergoline produced a significant rightward shift of the SKF 38393 dose-response function, indicating effective antagonism, although the degree of antagonism was not dose-related. These results support the view that the behavioral effects of D1-like receptor agonists differ in their susceptibility to antagonism by D1-like receptor antagonists, and that some effects of SKF 38393 may be mediated by serotonergic activity rather than by activity at D1-like receptors. JF - Behavioural pharmacology AU - Katz, Jonathan L AU - Kopajtic, Theresa A AU - Terry, Philip AD - Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. jkatz@intra.nida.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 303 EP - 309 VL - 17 IS - 4 SN - 0955-8810, 0955-8810 KW - Benzazepines KW - 0 KW - Dopamine Agonists KW - Dopamine Antagonists KW - Receptors, Dopamine D1 KW - SK&F 77434 KW - 104422-04-0 KW - Metergoline KW - 1501393LY5 KW - Spiperone KW - 4X6E73CJ0Q KW - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine KW - 67287-49-4 KW - SK&F 82958 KW - 80751-65-1 KW - Index Medicus KW - Animals KW - Benzazepines -- pharmacology KW - Metergoline -- pharmacology KW - Reinforcement Schedule KW - Dopamine Antagonists -- pharmacology KW - Spiperone -- pharmacology KW - Radioligand Assay KW - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Reward KW - Dopamine Agonists -- pharmacology KW - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine -- analogs & derivatives KW - Drug Synergism KW - Male KW - Conditioning, Operant -- drug effects KW - Receptors, Dopamine D1 -- agonists KW - Food KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68763812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Effects+of+dopamine+D1-like+receptor+agonists+on+food-maintained+operant+behavior+in+rats.&rft.au=Katz%2C+Jonathan+L%3BKopajtic%2C+Theresa+A%3BTerry%2C+Philip&rft.aulast=Katz&rft.aufirst=Jonathan&rft.date=2006-06-01&rft.volume=17&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-15 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biological optimization of heterogeneous dose distributions in systemic radiotherapy. AN - 68679827; 16872093 AB - The standard computational method developed for internal radiation dosimetry is the MIRD (medical internal radiation dose) formalism, based on the assumption that tumor control is given by uniform dose and activity distributions. In modern systemic radiotherapy, however, the need for full 3D dose calculations that take into account the heterogeneous distribution of activity in the patient is now understood. When information on nonuniform distribution of activity becomes available from functional imaging, a more patient specific 3D dosimetry can be performed. Application of radiobiological models can be useful to correlate the calculated heterogeneous dose distributions to the current knowledge on tumor control probability of a homogeneous dose distribution. Our contribution to this field is the introduction of a parameter, the F factor, already used by our group in studying external beam radiotherapy treatments. This parameter allows one to write a simplified expression for tumor control probability (TCP) based on the standard linear quadratic (LQ) model and Poisson statistics. The LQ model was extended to include different treatment regimes involving source decay, incorporating the repair "micro" of sublethal radiation damage, the relative biological effectiveness and the effective "waste" of dose delivered when repopulation occurs. The sensitivity of the F factor against radiobiological parameters (alpha, beta, micro) and the influence of the dose volume distribution was evaluated. Some test examples for 131I and 90Y labeled pharmaceuticals are described to further explain the properties of the F factor and its potential applications. To demonstrate dosimetric feasibility and advantages of the proposed F factor formalism in systemic radiotherapy, we have performed a retrospective planning study on selected patient case. F factor formalism helps to assess the total activity to be administered to the patient taking into account the heterogeneity in activity uptake and dose distribution, giving the same TCP of a homogeneous prescribed dose distribution. Animal studies and collection of standardized clinical data are needed to ascertain the effects of nonuniform dose distributions and to better assess the radiobiological input parameters of the model based on LQ model. JF - Medical physics AU - Strigari, Lidia AU - D'Andrea, Marco AU - Maini, Carlo Ludovico AU - Sciuto, Rosa AU - Benassi, Marcello AD - Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, Rome, Italy. strigari@ifo.it Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1857 EP - 1866 VL - 33 IS - 6 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Radiotherapy Planning, Computer-Assisted KW - Relative Biological Effectiveness KW - Radiotherapy Dosage KW - Radiation Injuries -- prevention & control KW - Humans KW - Poisson Distribution KW - Models, Biological KW - Neoplasms -- pathology KW - Neoplasms -- radiotherapy KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68679827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Biological+optimization+of+heterogeneous+dose+distributions+in+systemic+radiotherapy.&rft.au=Strigari%2C+Lidia%3BD%27Andrea%2C+Marco%3BMaini%2C+Carlo+Ludovico%3BSciuto%2C+Rosa%3BBenassi%2C+Marcello&rft.aulast=Strigari&rft.aufirst=Lidia&rft.date=2006-06-01&rft.volume=33&rft.issue=6&rft.spage=1857&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility. AN - 68652591; 16848974 AB - Nasopharyngeal carcinoma (NPC) is a complex disease caused by a combination of Epstein-Barr virus chronic infection, the environment and host genes in a multi-step process of carcinogenesis. The identity of genetic factors involved in the development of chronic Epstein-Barr virus infection and NPC remains elusive, however. Here, we describe a two-phase, population-based, case-control study of Han Chinese from Guangxi province, where the NPC incidence rate rises to a high of 25-50 per 100,000 individuals. Phase I, powered to detect single gene associations, enrolled 984 subjects to determine feasibility, to develop infrastructure and logistics and to determine error rates in sample handling. A microsatellite screen of Phase I study participants, genotyped for 319 alleles from 34 microsatellites spanning an 18-megabase region of chromosome 4 (4p15.1-q12), previously implicated by a linkage analysis of familial NPC, found 14 alleles marginally associated with developing NPC or chronic immunoglobulin A production (p=0.001-0.03). These associations lost significance after applying a correction for multiple tests. Although the present results await confirmation, the Phase II study population has tripled patient enrollment and has included environmental covariates, offering the potential to validate this and other genomic regions that influence the onset of NPC. JF - Human genomics AU - Guo, Xiu Chan AU - Scott, Kevin AU - Liu, Yan AU - Dean, Michael AU - David, Victor AU - Nelson, George W AU - Johnson, Randall C AU - Dilks, Holli H AU - Lautenberger, James AU - Kessing, Bailey AU - Martenson, Janice AU - Guan, Li AU - Sun, Shan AU - Deng, Hong AU - Zheng, Yuming AU - de The, Guy AU - Liao, Jian AU - Zeng, Yi AU - O'Brien, Stephen J AU - Winkler, Cheryl A AD - Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 365 EP - 375 VL - 2 IS - 6 KW - Genetic Markers KW - 0 KW - Immunoglobulin A KW - Index Medicus KW - Gene Frequency KW - Humans KW - Immunoglobulin A -- immunology KW - Linkage Disequilibrium -- genetics KW - Aged KW - Alleles KW - Feasibility Studies KW - China -- epidemiology KW - Chromosomes, Human, Pair 4 -- genetics KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Chronic Disease KW - Adolescent KW - Male KW - Female KW - Genetic Predisposition to Disease -- genetics KW - Epstein-Barr Virus Infections -- ethnology KW - Epstein-Barr Virus Infections -- epidemiology KW - Nasopharyngeal Neoplasms -- epidemiology KW - Nasopharyngeal Neoplasms -- genetics KW - Nasopharyngeal Neoplasms -- ethnology KW - Epstein-Barr Virus Infections -- genetics KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68652591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genomics&rft.atitle=Genetic+factors+leading+to+chronic+Epstein-Barr+virus+infection+and+nasopharyngeal+carcinoma+in+South+East+China%3A+study+design%2C+methods+and+feasibility.&rft.au=Guo%2C+Xiu+Chan%3BScott%2C+Kevin%3BLiu%2C+Yan%3BDean%2C+Michael%3BDavid%2C+Victor%3BNelson%2C+George+W%3BJohnson%2C+Randall+C%3BDilks%2C+Holli+H%3BLautenberger%2C+James%3BKessing%2C+Bailey%3BMartenson%2C+Janice%3BGuan%2C+Li%3BSun%2C+Shan%3BDeng%2C+Hong%3BZheng%2C+Yuming%3Bde+The%2C+Guy%3BLiao%2C+Jian%3BZeng%2C+Yi%3BO%27Brien%2C+Stephen+J%3BWinkler%2C+Cheryl+A&rft.aulast=Guo&rft.aufirst=Xiu&rft.date=2006-06-01&rft.volume=2&rft.issue=6&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Human+genomics&rft.issn=1479-7364&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncology. 2001;61(1):55-8 [11474249] Arch Otolaryngol Head Neck Surg. 2006 Jan;132(1):82-5 [16415435] Nat Genet. 2002 Aug;31(4):395-9 [12118254] Int J Cancer. 2002 Sep 10;101(2):146-50 [12209991] Semin Cancer Biol. 2002 Dec;12(6):421-9 [12450728] Semin Cancer Biol. 2002 Dec;12(6):443-50 [12450730] J Natl Cancer Inst. 2002 Dec 4;94(23):1780-9 [12464650] Int J Cancer. 2003 Feb 20;103(5):680-5 [12494479] Int J Cancer. 2003 Mar 1;103(6):745-51 [12516093] Am J Epidemiol. 2004 Jan 1;159(1):17-22 [14693655] Cancer Res. 2004 Mar 15;64(6):1972-4 [15026332] Int J Cancer. 1982 Feb 15;29(2):139-41 [6895884] Intervirology. 1983;20(4):190-4 [6317603] Int J Cancer. 1984 Jun 15;33(6):813-9 [6329970] Int J Cancer. 1985 Nov 15;36(5):545-7 [4055129] Int J Radiat Oncol Biol Phys. 1988 Nov;15(5):1119-27 [3182344] Lancet. 1990 Feb 17;335(8686):371-4 [1968116] Anticancer Res. 1989 Nov-Dec;9(6):1649-53 [2697183] Cancer. 2000 Mar 15;88(6):1393-402 [10717622] Oncogene. 2000 Apr 13;19(16):2023-32 [10803463] Biotechniques. 2001 Jul;31(1):24-6, 28 [11464515] Cancer. 2004 Jul 15;101(2):363-9 [15241835] Cancer Res. 1974 May;34(5):1189-91 [4842361] Int J Cancer. 1976 Jan 15;17(1):1-7 [175020] Cancer. 1976 Mar;37(3):1464-8 [1260665] Int J Cancer. 1990 Jun 15;45(6):1033-9 [2351484] Int J Cancer. 1990 Sep 15;46(3):421-5 [2394508] Cancer. 1991 Sep 15;68(6):1323-8 [1651806] Cancer. 1992 Jan 1;69(1):3-7 [1309307] Head Neck. 1992 May-Jun;14(3):200-7 [1587737] Cancer Genet Cytogenet. 1995 May;81(1):42-5 [7773959] Chin Med J (Engl). 1995 Apr;108(4):300-3 [7789220] Environ Health Perspect. 1995 Nov;103 Suppl 8:269-73 [8741797] Science. 1996 Sep 13;273(5281):1516-7 [8801636] Int J Cancer. 1997 Apr 22;74(2):229-32 [9133461] Am J Hum Genet. 1998 Jul;63(1):259-66 [9634505] J Natl Cancer Inst. 1999 Jun 2;91(11):943-9 [10359546] Tissue Antigens. 2002 Mar;59(3):223-5 [12074714] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal alcohol syndrome and its long-term effects. AN - 68630323; 16832326 AB - Ancient scripture and paintings together with several medical reports on the effect of alcohol on the newborn over the past 300 years finally led to the description of the fetal alcohol syndrome in the 1970s by French and American research groups. Maternal alcohol abuse during pregnancy can result in the specific pattern of malformations and neurocognitive deficits characteristic of this syndrome. Diagnostic criteria and classifications have been developed and in the 1990s reports showed the long-term consequences for these children. In recent years several studies from different countries have shown that prenatal alcohol exposure will lead to life-long consequences on physical development, intellectual development, behavior, social development, occupation, independence, sexuality or sexual behavior and increased risk of suicidality. In this review of long-term observation studies we found that the prenatal exposure to alcohol have permanent and life-long damage, which impair both the social and occupational future of the person exposed with a need for life-long assistance in order for that person to function at an optimal level. Primary prevention and early intervention with general public health educational efforts seems to be the best way forward. JF - Minerva pediatrica AU - Merrick, J AU - Merrick, E AU - Morad, M AU - Kandel, I AD - National Institute of Child Health and Human Development, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel. jmerrick@internet-zahav.net Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 211 EP - 218 VL - 58 IS - 3 SN - 0026-4946, 0026-4946 KW - Index Medicus KW - Intellectual Disability -- etiology KW - Age Factors KW - Primary Prevention KW - Developmental Disabilities -- etiology KW - Humans KW - Adult KW - Suicide KW - Follow-Up Studies KW - Child KW - Longitudinal Studies KW - Health Education KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Pregnancy KW - Fetal Alcohol Spectrum Disorders -- prevention & control KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68630323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Minerva+pediatrica&rft.atitle=Fetal+alcohol+syndrome+and+its+long-term+effects.&rft.au=Merrick%2C+J%3BMerrick%2C+E%3BMorad%2C+M%3BKandel%2C+I&rft.aulast=Merrick&rft.aufirst=J&rft.date=2006-06-01&rft.volume=58&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Minerva+pediatrica&rft.issn=00264946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation. AN - 68611166; 16820090 AB - Inhibitors of histone deacetylases have been shown to enhance the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand TRAIL-mediated cytotoxicity. Valproic acid (VA), a commonly used antiepileptic agent whose pharmacokinetics and toxicity profiles are well described, is a histone deacetylase inhibitor. This project aims to evaluate if VA can potentiate Apo2L/TRAIL-mediated cytotoxicity in cultured thoracic cancer cells and to elucidate the underlying molecular mechanism responsible for this effect. VA sensitized cultured thoracic cancer cells to Apo2L/TRAIL, as indicated by a 4-fold to a >20-fold reduction of Apo2L/TRAIL IC50 values in combination-treated cells. Although VA (0.5-5 mM) or Apo2L/TRAIL (20 ng/ml) induced less than 20% cell death, VA + Apo2L/TRAIL combinations caused 60% to 90% apoptosis of cancer cells. Moreover, substantial activation of caspases 8, 9, and 3, which was observed only in cells treated with the drug combination, was completely suppressed by Bcl2 overexpression or by the caspase 9 inhibitor. Both the caspase 9 inhibitor and Bcl2 completely abrogated the substantial cytotoxicity and apoptosis induced by this combination, thus highlighting the pivotal role of the type II pathway in this process. These findings provide a rationale for the development of VA and Apo2L/TRAIL combination as a novel molecular therapeutic for thoracic cancers. JF - Neoplasia (New York, N.Y.) AU - Ziauddin, M Firdos AU - Yeow, Wen-Shuz AU - Maxhimer, Justin B AU - Baras, Aris AU - Chua, Alex AU - Reddy, Rishindra M AU - Tsai, Wilson AU - Cole, George W AU - Schrump, David S AU - Nguyen, Dao M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 446 EP - 457 VL - 8 IS - 6 KW - Apoptosis Regulatory Proteins KW - 0 KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Membrane Glycoproteins KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - Tumor Necrosis Factor-alpha KW - Valproic Acid KW - 614OI1Z5WI KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Apoptosis KW - Enzyme Activation KW - Dose-Response Relationship, Drug KW - Humans KW - Apoptosis Regulatory Proteins -- metabolism KW - Cell Line, Tumor KW - Tumor Necrosis Factor-alpha -- metabolism KW - Drug Evaluation, Preclinical KW - Membrane Glycoproteins -- metabolism KW - Valproic Acid -- pharmacology KW - Thoracic Neoplasms -- drug therapy KW - Mitochondria -- enzymology KW - Lung Neoplasms -- drug therapy KW - Enzyme Inhibitors -- pharmacology KW - Epilepsy -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Caspases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68611166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia+%28New+York%2C+N.Y.%29&rft.atitle=Valproic+acid%2C+an+antiepileptic+drug+with+histone+deacetylase+inhibitory+activity%2C+potentiates+the+cytotoxic+effect+of+Apo2L%2FTRAIL+on+cultured+thoracic+cancer+cells+through+mitochondria-dependent+caspase+activation.&rft.au=Ziauddin%2C+M+Firdos%3BYeow%2C+Wen-Shuz%3BMaxhimer%2C+Justin+B%3BBaras%2C+Aris%3BChua%2C+Alex%3BReddy%2C+Rishindra+M%3BTsai%2C+Wilson%3BCole%2C+George+W%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Ziauddin&rft.aufirst=M&rft.date=2006-06-01&rft.volume=8&rft.issue=6&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Neoplasia+%28New+York%2C+N.Y.%29&rft.issn=1476-5586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-07-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1999 Jan 25;144(2):281-92 [9922454] Curr Opin Cell Biol. 1999 Apr;11(2):255-60 [10209153] J Clin Invest. 1999 Jul;104(2):155-62 [10411544] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7 [10500109] Mol Cancer Ther. 2004 Nov;3(11):1397-402 [15542778] Cell Death Differ. 2004 Dec;11 Suppl 2:S193-206 [15608694] Cancer Gene Ther. 2005 Mar;12(3):228-37 [15550937] Mol Cancer Ther. 2005 Aug;4(8):1222-30 [16093438] Semin Oncol. 2005 Oct;32(5):488-502 [16210090] Int J Cancer. 2006 Jan 1;118(1):230-42 [16003725] Cell Death Differ. 1999 Nov;6(11):1028-42 [10578171] Biochemistry. 2000 Feb 1;39(4):633-40 [10651627] J Biol Chem. 2000 Aug 11;275(32):24357-66 [10823821] Cell Death Differ. 2000 Nov;7(11):1101-8 [11139284] Cell Death Differ. 2000 Dec;7(12):1166-73 [11175253] Nat Med. 2001 Apr;7(4):383-5 [11283636] Am J Respir Cell Mol Biol. 2001 Jul;25(1):111-8 [11472983] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8 [11535817] J Pharmacol Exp Ther. 2001 Oct;299(1):31-8 [11561060] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] Nat Med. 2002 Mar;8(3):274-81 [11875499] Cancer Res. 2002 Mar 15;62(6):1583-7 [11912124] J Natl Cancer Inst. 2002 Apr 3;94(7):504-13 [11929951] Int J Mol Med. 2002 May;9(5):521-5 [11956660] Int J Cancer. 2002 Jun 1;99(4):491-504 [11992538] Med Res Rev. 2002 Sep;22(5):492-511 [12210556] Cell Death Differ. 2002 Oct;9(10):1031-42 [12232790] Neoplasia. 2002 Nov-Dec;4(6):551-7 [12407450] Cancer Res. 2002 Nov 1;62(21):6108-15 [12414635] Cancer Res. 2003 Feb 1;63(3):621-6 [12566305] Mol Cell. 2003 Feb;11(2):529-41 [12620239] Cell Death Differ. 2003 Jan;10(1):66-75 [12655296] Oncogene. 2003 Mar 27;22(12):1807-16 [12660816] Biochem Biophys Res Commun. 2003 May 9;304(3):437-44 [12729577] Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):337-48 [12787570] Blood. 2003 Jul 1;102(1):303-10 [12637321] EMBO J. 2003 Jul 1;22(13):3411-20 [12840003] Clin Cancer Res. 2003 Aug 1;9(8):3134-41 [12912965] Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3578-88 [14506144] Biochem Pharmacol. 2003 Oct 15;66(8):1537-45 [14555232] N Engl J Med. 2003 Dec 4;349(23):2241-52 [14657432] Expert Opin Investig Drugs. 2004 Jan;13(1):21-38 [14680450] Mol Cancer Ther. 2003 Dec;2(12):1273-84 [14707268] Biochem Biophys Res Commun. 2004 Jan 30;314(1):186-91 [14715264] N Engl J Med. 2004 Jan 22;350(4):379-92 [14736930] Cancer Res. 2004 Feb 1;64(3):1079-86 [14871841] Clin Cancer Res. 2004 Feb 1;10(3):1141-9 [14871994] Cancer Res. 2004 Apr 1;64(7):2580-9 [15059915] Oncogene. 2004 Apr 12;23(16):2861-74 [15077149] Drug Resist Updat. 2004 Apr;7(2):139-56 [15158769] Oncogene. 2004 Jul 15;23(32):5415-25 [15094781] Cancer Res. 2004 Jul 15;64(14):4900-5 [15256461] Exp Cell Res. 2004 Aug 15;298(2):560-73 [15265702] Curr Pharm Des. 2004;10(19):2289-98 [15279609] Oncogene. 2004 Aug 19;23(37):6261-71 [15208660] Carcinogenesis. 2004 Oct;25(10):1813-20 [15142888] Oncogene. 2004 Oct 7;23(46):7611-20 [15361826] Cancer Sci. 2004 Oct;95(10):777-83 [15504243] Cancer Res. 2005 Mar 1;65(5):2001-8 [15753400] Mol Ther. 2005 Apr;11(4):542-52 [15771957] Br J Cancer. 2005 Apr 25;92(8):1430-41 [15846298] Cell Cycle. 2005 Apr;4(4):549-51 [15738652] Clin Cancer Res. 2005 Jul 1;11(13 Pt 2):5017s-5021s [16000606] Oncogene. 2005 Jul 7;24(29):4609-23 [15897906] Neoplasia. 2005 Jul;7(7):646-57 [16026644] Mol Pharmacol. 1994 Jun;45(6):1207-14 [8022414] N Engl J Med. 1996 Jan 18;334(3):168-75 [8531974] J Biol Chem. 1996 May 31;271(22):12687-90 [8663110] EMBO J. 1998 Mar 16;17(6):1675-87 [9501089] Annu Rev Physiol. 1998;60:619-42 [9558479] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adolescent smokers screened for a nicotine replacement treatment trial: correlates of eligibility and enrollment. AN - 68577731; 16801302 AB - The enrollment process determines the study sample and external validity of clinical trial results; however, few reports describe the process and outcome of screening efforts for smoking cessation studies among adolescents. We describe and evaluate a screening protocol to enroll adolescent smokers for a randomized clinical trial of nicotine replacement therapy. Adolescent smokers obtained the recruitment call-in number (1-800-NO-SMOKE) via media and other advertisements. Trained recruitment staff collected information using an internally developed, targeted telephone screening interview, which was used to determine pre-eligibility for the clinical trial. Correlates of qualification and of study enrollment were determined. Among 1,347 adolescents screened, 329 (24.4%) were eligible to participate in the trial. Light smoking (39.1%) and lack of parental support (14.8%) were the biggest contributors to ineligibility. Eligible adolescents were more likely to be female (66.9% vs. 58.2%, p = .0052) and more likely to be European American (63.5% vs. 52.2%, p = .0003). The higher rates of ineligibility for African Americans and boys were partly explained by lower scores on the Fagerström Test for Nicotine Dependence. Of those eligible to participate in the trial, 159 (48.3%) enrolled. Results underscore the need for screening instruments that are measurement-invariant across ethnicities and gender, and for enrollment strategies that maximize inclusion of eligible participants. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Robinson, Miqun L AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - Clinical Pharmacology and Treatment Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services, MD 21224, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 447 EP - 454 VL - 8 IS - 3 SN - 1462-2203, 1462-2203 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Randomized Controlled Trials as Topic -- standards KW - Adolescent KW - Male KW - Female KW - Smoking -- therapy KW - Nicotine -- therapeutic use KW - Eligibility Determination KW - Adolescent Behavior KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68577731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Adolescent+smokers+screened+for+a+nicotine+replacement+treatment+trial%3A+correlates+of+eligibility+and+enrollment.&rft.au=Robinson%2C+Miqun+L%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Robinson&rft.aufirst=Miqun&rft.date=2006-06-01&rft.volume=8&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression. AN - 68568021; 16582428 AB - Hsp104 is a hexameric protein chaperone that resolubilizes stress-damaged proteins from aggregates. Hsp104 promotes [PSI(+)] prion propagation by breaking prion aggregates, which propagate as amyloid fibers, into more numerous prion "seeds." Inactivating Hsp104 cures cells of [PSI(+)] and other amyloid-like yeast prions. Overexpressing Hsp104 also eliminates [PSI(+)], presumably by completely resolubilizing prion aggregates. Inexplicably, however, excess Hsp104 does not cure the other prions. Here we identify missense mutations in Hsp104's amino-terminal domain (NTD), which is conserved among Hsp100 proteins but whose function is unknown, that improve [PSI(+)] propagation. Hsp104Delta147, engineered to lack the NTD, supported [PSI(+)] and functioned normally in thermotolerance and protein disaggregation. Hsp104Delta147 failed to cure [PSI(+)] when overexpressed, however, implying that excess Hsp104 does not eliminate [PSI(+)] by direct dissolution of prion aggregates. Curing of [PSI(+)] by overexpressing catalytically inactive Hsp104 (Hsp104KT), which interferes with endogenous Hsp104, did not require the NTD. We further found that Hsp104 mutants defective in threading peptides through the hexamer pore had reduced ability to support [PSI(+)] in proportion to protein resolubilization defects, suggesting that [PSI(+)] propagation depends on this threading and that Hsp104 "breaks" prion aggregates by extracting protein monomers from the amyloid fibers. JF - Genetics AU - Hung, Guo-Chiuan AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0851, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 611 EP - 620 VL - 173 IS - 2 SN - 0016-6731, 0016-6731 KW - HSP70 Heat-Shock Proteins KW - 0 KW - Heat-Shock Proteins KW - Peptide Termination Factors KW - Prions KW - SSA3 protein, S cerevisiae KW - SUP35 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - HsP104 protein, S cerevisiae KW - 143012-44-6 KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - HSP70 Heat-Shock Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- genetics KW - Alleles KW - Genes, Fungal KW - Temperature KW - Gene Expression KW - Protein Structure, Tertiary KW - Luciferases -- genetics KW - Protein Structure, Quaternary KW - Mutagenesis KW - Saccharomyces cerevisiae -- genetics KW - Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Prions -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Prions -- metabolism KW - Heat-Shock Proteins -- genetics KW - Heat-Shock Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68568021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=N-terminal+domain+of+yeast+Hsp104+chaperone+is+dispensable+for+thermotolerance+and+prion+propagation+but+necessary+for+curing+prions+by+Hsp104+overexpression.&rft.au=Hung%2C+Guo-Chiuan%3BMasison%2C+Daniel+C&rft.aulast=Hung&rft.aufirst=Guo-Chiuan&rft.date=2006-06-01&rft.volume=173&rft.issue=2&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2000 Jan;5(1):163-72 [10678178] J Biol Chem. 2006 Mar 17;281(11):7022-9 [16415353] Mol Cell Biol. 2000 Dec;20(23):8916-22 [11073991] J Bacteriol. 2000 Dec;182(24):7092-6 [11092876] Protein Sci. 2001 Mar;10(3):551-9 [11344323] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Mol Cell Biol. 2001 Jul;21(14):4656-69 [11416143] Mol Microbiol. 2001 Jun;40(6):1357-69 [11442834] Biochem Cell Biol. 2001;79(5):557-68 [11716297] EMBO J. 2001 Dec 3;20(23):6683-91 [11726504] Mol Cell. 2002 Mar;9(3):673-83 [11931773] Protein Sci. 2002 May;11(5):1192-8 [11967375] Mol Cell. 2002 Apr;9(4):751-60 [11983167] Mol Cell Biol. 2002 Jun;22(11):3590-8 [11997496] Mol Cell Biol. 2002 Aug;22(15):5593-605 [12101251] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9936-41 [12105276] FEBS Lett. 2002 Oct 2;529(1):6-10 [12354604] J Biol Chem. 2002 Dec 6;277(49):47160-6 [12351638] Curr Opin Struct Biol. 2002 Dec;12(6):746-53 [12504679] Genetics. 2003 Feb;163(2):495-506 [12618389] Mol Biol Cell. 2003 Mar;14(3):1172-81 [12631732] J Biol Chem. 2003 May 16;278(20):17615-24 [12624113] J Biol Chem. 2003 Aug 29;278(35):32608-17 [12805357] Cell. 2003 Oct 17;115(2):229-40 [14567920] J Biol Chem. 2003 Dec 5;278(49):49636-43 [14507919] J Biol Chem. 2004 Feb 27;279(9):7378-83 [14668331] Biotechniques. 2004 Mar;36(3):398-400 [15038153] Mol Cell Biol. 2004 May;24(9):3928-37 [15082786] Mol Biol Cell. 2004 May;15(5):2061-72 [14978213] Science. 2004 Jun 18;304(5678):1793-7 [15155912] J Biol Chem. 2004 Jul 9;279(28):29139-46 [15128736] J Biol Chem. 2004 Oct 22;279(43):44376-83 [15302880] Biochem Biophys Res Commun. 1969 Feb 7;34(3):301-5 [5767024] J Cell Biol. 1988 Dec;107(6 Pt 1):2051-7 [3058716] Genetics. 1989 May;122(1):19-27 [2659436] Methods Enzymol. 1991;194:3-21 [2005794] Yeast. 1991 Feb;7(2):173-83 [1905859] Nature. 1991 Sep 19;353(6341):270-3 [1896074] Cell. 1992 Oct 2;71(1):97-105 [1394434] Science. 1994 Apr 22;264(5158):566-9 [7909170] Nature. 1994 Dec 1;372(6505):475-8 [7984243] Science. 1995 May 12;268(5212):880-4 [7754373] EMBO J. 1996 Jun 17;15(12):3127-34 [8670813] Trends Biochem Sci. 1996 Aug;21(8):289-96 [8772382] Genetics. 1997 Oct;147(2):507-19 [9335589] J Biol Chem. 1998 Jun 19;273(25):15546-52 [9624144] Cell. 1998 Jul 10;94(1):13-6 [9674422] Cell. 1998 Jul 10;94(1):73-82 [9674429] Cell. 2004 Nov 24;119(5):653-65 [15550247] J Biol Chem. 2004 Dec 10;279(50):52319-23 [15448141] Eukaryot Cell. 2005 Feb;4(2):289-97 [15701791] FEBS Lett. 2005 Aug 15;579(20):4242-8 [16051221] J Biol Chem. 2005 Oct 14;280(41):34940-5 [16076845] Genetics. 2000 Oct;156(2):559-70 [11014806] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thymidine phosphorylase (platelet-derived endothelial cell growth factor) as a target for capecitabine: from biology to the bedside. AN - 68396191; 18221035 AB - Thymidine phosphorylase (TP), also known as platelet derived endothelial cell growth factor (PD-ECGF), is an enzyme involved in thymidine synthesis and degradation and exerts an angiogenic activity, whereas N4 pentyloxy-carbonyl- 5'-deoxy-5-fluorocytidine, commonly called capecitabine (CAP), is a TP-activated oral fluorpyrimidine, which generates 5-fluorouracil (5-FU) within tumours. In addition to its classic antitumour activity, recent studies suggest that CAP may act as an antiangiogenetic molecule. Assessment of tumour microvessel density as expressed by endothelial cell TP positivity may identify the most vascularized and hence CAP-sensitive tumours. This review summarizes: (i) the biochemical and tissue expression of TP; (ii) the pharmacological profile of CAP as an anti-cancer compound and the central role of TP in its activation; (iii) the potential antiangiogenetic role of TP-activated CAP in tumours. JF - Recent patents on anti-cancer drug discovery AU - Ranieri, Girolamo AU - Roccaro, Aldo Maria AU - Vacca, Angelo AU - Ribatti, Domenico AD - National Cancer Institute, Interventional Radiology Unit, Bari, Italy. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 171 EP - 183 VL - 1 IS - 2 SN - 1574-8928, 1574-8928 KW - Angiogenesis Inhibitors KW - 0 KW - Antimetabolites, Antineoplastic KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Thymidine Phosphorylase KW - EC 2.4.2.4 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Humans KW - Up-Regulation -- drug effects KW - Clinical Trials as Topic KW - Patents as Topic KW - Up-Regulation -- radiation effects KW - Regional Blood Flow KW - Radiotherapy -- adverse effects KW - Angiogenesis Inhibitors -- therapeutic use KW - Neoplasms -- drug therapy KW - Thymidine Phosphorylase -- biosynthesis KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- therapeutic use KW - Antimetabolites, Antineoplastic -- pharmacology KW - Fluorouracil -- therapeutic use KW - Angiogenesis Inhibitors -- pharmacology KW - Neovascularization, Pathologic -- drug therapy KW - Neoplasms -- blood supply KW - Thymidine Phosphorylase -- antagonists & inhibitors KW - Fluorouracil -- analogs & derivatives KW - Fluorouracil -- pharmacology KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Deoxycytidine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68396191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+patents+on+anti-cancer+drug+discovery&rft.atitle=Thymidine+phosphorylase+%28platelet-derived+endothelial+cell+growth+factor%29+as+a+target+for+capecitabine%3A+from+biology+to+the+bedside.&rft.au=Ranieri%2C+Girolamo%3BRoccaro%2C+Aldo+Maria%3BVacca%2C+Angelo%3BRibatti%2C+Domenico&rft.aulast=Ranieri&rft.aufirst=Girolamo&rft.date=2006-06-01&rft.volume=1&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Recent+patents+on+anti-cancer+drug+discovery&rft.issn=15748928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. AN - 68084118; 16780351 AB - Goldenseal is an herb that is widely used in dietary supplements, eye washes, and skin lotions. The presence of Goldenseal root powder in dietary supplements and the topical application of Goldenseal preparations raise the possibility that an adverse phototoxic reaction may result from an interaction between its constituent alkaloids and light in exposed tissues. We have previously shown that berberine, the major alkaloid in Goldenseal powder, in combination with UVA causes DNA damage and cell death in HaCaT keratinocytes [(2001) Chem. Res. Toxicol. 14, 1529]. We have studied the photochemical and photobiological properties of four minor alkaloids found in Goldenseal, namely, hydrastine, palmatine, canadine, and hydrastinine. UVA radiation of palmatine in aqueous solutions generated no (1)O(2), but in CH(2)Cl(2), copious amounts of (1)O(2) were detected (Phi = 0.2). Palmatine also photogenerated oxygen-centered radicals, (*)OH and O(2)(*)(-) in aerated aqueous buffer and acetonitrile, respectively, as detected by the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO). In nitrogen-sparged acetonitrile containing DMPO, we observed the neutral palmatine radical formed by one-electron reduction. UVA irradiation (4 J/cm(2)) of HaCaT keratinocytes in the presence of palmatine (50 microM) resulted in a 50% decrease in cell viability but no DNA damage as measured by the comet assay. UVA irradiation of hydrastine, hydrastinine, or canadine (50 microM) did not cause DNA damage or cell death in keratinocytes. Although palmatine is photoactive, it is present in such small amounts in Goldenseal root powder that the phototoxicity of the herb is most likely due to berberine, the major constituent alkaloid. JF - Chemical research in toxicology AU - Inbaraj, J J AU - Kukielczak, B M AU - Bilski, P AU - He, Y-Y AU - Sik, R H AU - Chignell, C F AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 739 EP - 744 VL - 19 IS - 6 SN - 0893-228X, 0893-228X KW - Alkaloids KW - 0 KW - Benzylisoquinolines KW - Berberine Alkaloids KW - Photosensitizing Agents KW - Tetrahydroisoquinolines KW - Berberine KW - 0I8Y3P32UF KW - hydrastine KW - 8890V3217X KW - palmatine KW - G50C034217 KW - Oxygen KW - S88TT14065 KW - hydrastinine KW - V1I0L48X6E KW - canadine KW - V2SSH085X8 KW - Index Medicus KW - Photochemistry KW - Berberine -- chemistry KW - Molecular Structure KW - Humans KW - Berberine -- analogs & derivatives KW - Berberine -- toxicity KW - Berberine Alkaloids -- toxicity KW - Berberine Alkaloids -- chemistry KW - Spectrum Analysis KW - Cell Survival -- drug effects KW - Oxygen -- chemistry KW - Cell Survival -- radiation effects KW - Cell Line KW - Photosensitizing Agents -- chemistry KW - Alkaloids -- chemistry KW - Tetrahydroisoquinolines -- chemistry KW - Alkaloids -- toxicity KW - Hydrastis -- chemistry KW - Photosensitizing Agents -- pharmacology KW - Tetrahydroisoquinolines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68084118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Photochemistry+and+photocytotoxicity+of+alkaloids+from+Goldenseal+%28Hydrastis+canadensis+L.%29.+2.+Palmatine%2C+hydrastine%2C+canadine%2C+and+hydrastinine.&rft.au=Inbaraj%2C+J+J%3BKukielczak%2C+B+M%3BBilski%2C+P%3BHe%2C+Y-Y%3BSik%2C+R+H%3BChignell%2C+C+F&rft.aulast=Inbaraj&rft.aufirst=J&rft.date=2006-06-01&rft.volume=19&rft.issue=6&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. AN - 68083862; 16780361 AB - The areca alkaloids comprise arecoline, arecaidine, guvacoline, and guvacine. Approximately 600 million users of areca nut products, for example, betel quid chewers, are exposed to these alkaloids, principally arecoline and arecaidine. Metabolism of arecoline (20 mg/kg p.o. and i.p.) and arecaidine (20 mg/kg p.o. and i.p.) was investigated in the mouse using a metabolomic approach employing ultra-performance liquid chromatography-time-of-flight mass spectrometric analysis of urines. Eleven metabolites of arecoline were identified, including arecaidine, arecoline N-oxide, arecaidine N-oxide, N-methylnipecotic acid, N-methylnipecotylglycine, arecaidinylglycine, arecaidinylglycerol, arecaidine mercapturic acid, arecoline mercapturic acid, and arecoline N-oxide mercapturic acid, together with nine unidentified metabolites. Arecaidine shared six of these metabolites with arecoline. Unchanged arecoline comprised 0.3-0.4%, arecaidine 7.1-13.1%, arecoline N-oxide 7.4-19.0%, and N-methylnipecotic acid 13.5-30.3% of the dose excreted in 0-12 h urine after arecoline administration. Unchanged arecaidine comprised 15.1-23.0%, and N-methylnipecotic acid 14.8%-37.7% of the dose excreted in 0-12 h urine after arecaidine administration. The major metabolite of both arecoline and arecaidine, N-methylnipecotic acid, is a novel metabolite arising from carbon-carbon double-bond reduction. Another unusual metabolite found was the monoacylglyceride of arecaidine. What role, if any, that is played by these uncommon metabolites in the toxicology of arecoline and arecaidine is not known. However, the enhanced understanding of the metabolic transformation of arecoline and arecaidine should contribute to further research into the clinical toxicology of the areca alkaloids. JF - Chemical research in toxicology AU - Giri, Sarbani AU - Idle, Jeffrey R AU - Chen, Chi AU - Zabriskie, T Mark AU - Krausz, Kristopher W AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 818 EP - 827 VL - 19 IS - 6 SN - 0893-228X, 0893-228X KW - arecaidine KW - 0S8YEV0D4O KW - Arecoline KW - 4ALN5933BH KW - Index Medicus KW - Molecular Structure KW - Animals KW - Gas Chromatography-Mass Spectrometry KW - Mice KW - Male KW - Areca -- chemistry KW - Arecoline -- analogs & derivatives KW - Arecoline -- pharmacology KW - Arecoline -- chemistry KW - Arecoline -- administration & dosage KW - Arecoline -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68083862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=A+metabolomic+approach+to+the+metabolism+of+the+areca+nut+alkaloids+arecoline+and+arecaidine+in+the+mouse.&rft.au=Giri%2C+Sarbani%3BIdle%2C+Jeffrey+R%3BChen%2C+Chi%3BZabriskie%2C+T+Mark%3BKrausz%2C+Kristopher+W%3BGonzalez%2C+Frank+J&rft.aulast=Giri&rft.aufirst=Sarbani&rft.date=2006-06-01&rft.volume=19&rft.issue=6&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: IARC Monogr Eval Carcinog Risks Hum. 2004;85:1-334 [15635762] Clin Chim Acta. 1999 Sep;287(1-2):145-56 [10509903] Rapid Commun Mass Spectrom. 2005;19(8):984-1004 [15765472] J Proteome Res. 2005 Mar-Apr;4(2):591-8 [15822939] Drug Discov Today. 2005 Nov 15;10(22):1551-8 [16257378] J Biochem Mol Toxicol. 2000;14(2):102-9 [10630424] Clin Oral Investig. 2001 Mar;5(1):51-6 [11355099] Carcinogenesis. 2001 Sep;22(9):1527-35 [11532876] Addict Biol. 2002 Jan;7(1):77-83 [11900626] Addict Biol. 2002 Jan;7(1):133-8 [11900633] Biosci Biotechnol Biochem. 2002 Mar;66(3):622-7 [12005058] J Mol Biol. 2003 Mar 14;327(1):47-59 [12614607] J Biol Chem. 2003 May 30;278(22):20154-61 [12654921] Drug Metab Dispos. 2004 Sep;32(9):966-72 [15319338] Arzneimittelforschung. 1968 Feb;18(2):222-5 [5695384] Biochem J. 1969 Jun;113(1):123-30 [5806385] Biochem J. 1971 May;122(4):503-8 [5123883] Mol Pharmacol. 1983 May;23(3):761-5 [6865918] J Cancer Res Clin Oncol. 1984;108(1):110-3 [6746701] Carcinogenesis. 1984 Sep;5(9):1137-40 [6547885] IARC Sci Publ. 1984;(57):859-66 [6549450] Clin Pharmacol Ther. 1987 Dec;42(6):608-12 [3690938] Life Sci. 1991;49(9):629-49 [1865757] Gen Pharmacol. 1993 May;24(3):641-7 [8365645] Clin Pharmacol Ther. 1996 Sep;60(3):276-82 [8841150] Pharmacol Rev. 2005 Mar;57(1):79-115 [15734728] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammation-related gene polymorphisms and colorectal adenoma. AN - 68077117; 16775170 AB - Chronic inflammation has been reported to be a risk factor for colorectal neoplasia. The propensity to mount an inflammatory response is modified by germ line variation in cytokine and other inflammation-related genes. We hypothesized that a proinflammatory genotype would be positively associated with colorectal adenoma, a precursor of colorectal cancer. We investigated the association of colorectal adenoma with 19 single nucleotide polymorphisms in a range of important proinflammatory (IL1B, IL6, IL8, TNF, and LTA) and anti-inflammatory (IL4, IL10, and IL13) cytokines and other inflammation-related genes (PTGS2 and PPARG) in a case-control study of risk factors for colorectal polyps in which all participants (ages 18-74 years) had undergone colonoscopy or sigmoidoscopy. The study sample comprised 244 cases of colorectal adenoma and 231 polyp-free controls. Compared with being homozygous for the common allele, heterozygosity at the IL1B -31 (C>T) locus was associated with an odds ratio (OR) for colorectal adenoma of 1.8 [95% confidence interval (95% CI), 1.2-2.9]. Homozygous carriers of the IL8 -251-A allele were at 2.7-fold increased risk of adenoma (95% CI, 1.5-4.9) compared with homozygosity for the common T allele, whereas carriage of at least one IL8 -251-A allele conferred a 1.5 increased odds of disease (95% CI, 1.0-2.4). Among non-nonsteroidal anti-inflammatory drug users, there was a statistically significant association between the IL10 -819-T/T genotype and adenoma compared with the common IL10 -819-C/C genotype (OR, 3.9; 95% CI, 1.1-13.6), which was not evident among nonsteroidal anti-inflammatory drug users (OR, 0.7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Gunter, Marc J AU - Canzian, Federico AU - Landi, Stefano AU - Chanock, Stephen J AU - Sinha, Rashmi AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA. mgunter@aecom.yu.edu Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1126 EP - 1131 VL - 15 IS - 6 SN - 1055-9965, 1055-9965 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Biomarkers, Tumor KW - Cytokines KW - Index Medicus KW - Genetic Variation KW - Odds Ratio KW - Neoplasm Staging KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Aged KW - Polymerase Chain Reaction KW - Colonoscopy KW - Survival Rate KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Colonic Polyps -- genetics KW - Female KW - Male KW - Colonic Polyps -- pathology KW - Biomarkers, Tumor -- genetics KW - Adenomatous Polyps -- genetics KW - Cytokines -- genetics KW - Cytokines -- drug effects KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- therapy KW - Adenomatous Polyps -- therapy KW - Inflammation -- genetics KW - Adenomatous Polyps -- pathology KW - Cytokines -- metabolism KW - Colorectal Neoplasms -- genetics KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68077117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Inflammation-related+gene+polymorphisms+and+colorectal+adenoma.&rft.au=Gunter%2C+Marc+J%3BCanzian%2C+Federico%3BLandi%2C+Stefano%3BChanock%2C+Stephen+J%3BSinha%2C+Rashmi%3BRothman%2C+Nathaniel&rft.aulast=Gunter&rft.aufirst=Marc&rft.date=2006-06-01&rft.volume=15&rft.issue=6&rft.spage=1126&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2. AN - 68061419; 16766264 AB - In the liver, derangement of TGF-beta signaling is associated with an increased incidence of hepatocellular carcinoma (HCC), but the mechanism is not clear. We report here that forced expression of a major TGF-beta signaling transducer, Smad3, reduces susceptibility to HCC in a chemically induced murine model. This protection is conferred by Smad3's ability to promote apoptosis by repressing Bcl-2 transcription in vivo through a GC-rich element in the Bcl-2 promoter. We also show that the proapoptotic activity of Smad3 requires both input from TGF-beta signaling and activation of p38 MAPK, which occurs selectively in the liver tumor cells. Thus, Smad3 enables the tumor suppression function of TGF-beta by serving as a physiological mediator of TGF-beta-induced apoptosis. JF - Cancer cell AU - Yang, Yu-An AU - Zhang, Gen-Mu AU - Feigenbaum, Lionel AU - Zhang, Ying E AD - Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 445 EP - 457 VL - 9 IS - 6 SN - 1535-6108, 1535-6108 KW - Proto-Oncogene Proteins c-bcl-2 KW - 0 KW - Smad3 Protein KW - Smad3 protein, mouse KW - Transforming Growth Factor beta KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Transforming Growth Factor beta -- physiology KW - Down-Regulation KW - Disease Susceptibility KW - Cells, Cultured KW - Transcription, Genetic KW - Mice KW - Mice, Transgenic KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Signal Transduction KW - Protein Transport KW - Smad3 Protein -- biosynthesis KW - Apoptosis KW - Liver Neoplasms, Experimental -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- physiology KW - Liver Neoplasms, Experimental -- chemically induced KW - Hepatocytes -- pathology KW - Smad3 Protein -- genetics KW - Carcinoma, Hepatocellular -- metabolism KW - Liver Neoplasms, Experimental -- pathology KW - Carcinoma, Hepatocellular -- pathology KW - Smad3 Protein -- physiology KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Carcinoma, Hepatocellular -- chemically induced KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68061419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+cell&rft.atitle=Smad3+reduces+susceptibility+to+hepatocarcinoma+by+sensitizing+hepatocytes+to+apoptosis+through+downregulation+of+Bcl-2.&rft.au=Yang%2C+Yu-An%3BZhang%2C+Gen-Mu%3BFeigenbaum%2C+Lionel%3BZhang%2C+Ying+E&rft.aulast=Yang&rft.aufirst=Yu-An&rft.date=2006-06-01&rft.volume=9&rft.issue=6&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Cancer+cell&rft.issn=15356108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1997 Jul 1;57(13):2578-80 [9205057] Nature. 1997 Jul 17;388(6639):304-8 [9230443] J Biol Chem. 1997 Aug 15;272(33):20490-4 [9252360] Nature. 1997 Sep 25;389(6649):349-52 [9311776] Oncogene. 2003 Aug 11;22(33):5093-107 [12910247] Oncol Rep. 1998 Jan-Feb;5(1):41-4 [9458289] Nat Med. 1998 Jul;4(7):802-7 [9662371] Genes Dev. 1998 Jul 15;12(14):2153-63 [9679060] Nature. 1998 Aug 27;394(6696):909-13 [9732876] Annu Rev Biochem. 1998;67:753-91 [9759503] Oncogene. 1998 Oct 15;17(15):1959-68 [9788439] EMBO J. 1999 Mar 1;18(5):1280-91 [10064594] Genes Dev. 1999 Apr 1;13(7):804-16 [10197981] Hepatology. 1999 Jun;29(6):1909-10 [10347138] Am J Pathol. 1999 Jun;154(6):1693-700 [10362794] Genes Dev. 1999 Aug 1;13(15):1899-911 [10444588] Cell Res. 2005 Jan;15(1):11-8 [15686620] Cytokine Growth Factor Rev. 2005 Feb;16(1):15-34 [15733830] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Oncogene. 2005 Apr 21;24(18):3028-41 [15735717] Nature. 2005 Jun 2;435(7042):677-81 [15902208] Mol Biol Cell. 1999 Nov;10(11):3801-13 [10564272] J Biol Chem. 1999 Dec 24;274(52):37413-20 [10601313] J Biol Chem. 2000 Mar 3;275(9):6499-508 [10692454] Am J Physiol Gastrointest Liver Physiol. 2000 Mar;278(3):G354-66 [10712254] J Cell Biol. 2000 May 1;149(3):667-82 [10791980] Hepatology. 2000 Oct;32(4 Pt 1):750-60 [11003619] Nat Cell Biol. 2000 Dec;2(12):915-21 [11146656] Microsc Res Tech. 2001 Feb 15;52(4):430-6 [11170302] Nat Struct Biol. 2001 Mar;8(3):248-53 [11224571] Nature. 2001 May 24;411(6836):494-8 [11373684] Nat Cell Biol. 2001 Aug;3(8):708-14 [11483955] Oncogene. 2001 Aug 16;20(36):5015-24 [11526486] Cancer Res. 2001 Sep 15;61(18):6665-8 [11559531] Nat Genet. 2001 Oct;29(2):117-29 [11586292] Nat Cell Biol. 2002 Jan;4(1):51-8 [11740493] EMBO J. 2002 Jul 15;21(14):3749-59 [12110587] Nat Rev Drug Discov. 2002 Feb;1(2):111-21 [12120092] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Cancer Res. 2002 Oct 15;62(20):5627-31 [12384514] J Clin Invest. 2003 Jan;111(1):129-39 [12511596] Cancer Treat Rev. 2003 Apr;29(2):99-104 [12670452] Hepatology. 2003 May;37(5):1067-78 [12717387] Cell. 2003 Jun 13;113(6):685-700 [12809600] Nature. 2003 Oct 9;425(6958):577-84 [14534577] J Biol Chem. 2004 Feb 6;279(6):4632-41 [14610078] Nat Cell Biol. 2004 Apr;6(4):358-65 [15048128] Nat Cell Biol. 2004 Apr;6(4):366-72 [15104092] Nature. 2004 Jul 8;430(6996):226-31 [15241418] N Engl J Med. 2004 Aug 5;351(6):552-9 [15295048] Oncogene. 2004 Sep 23;23(44):7416-29 [15326485] J Clin Invest. 1987 Nov;80(5):1512-5 [3500184] J Cell Physiol. 1989 Jan;138(1):79-86 [2910889] Annu Rev Pharmacol Toxicol. 1990;30:465-500 [2188576] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5408-12 [1608949] Nature. 1993 Aug 26;364(6440):806-9 [7689176] Carcinogenesis. 1994 Sep;15(9):1791-8 [7923571] Carcinogenesis. 1994 Dec;15(12):2763-7 [8001232] Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2572-6 [7708687] J Exp Med. 1995 Nov 1;182(5):1223-30 [7595193] J Clin Pathol. 1995 Dec;48(12):1093-7 [8567993] Biochem Biophys Res Commun. 1996 May 6;222(1):64-70 [8630075] Cancer Res. 1996 Aug 1;56(15):3391-4 [8758899] Nature. 1996 Sep 12;383(6596):168-72 [8774881] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10933-8 [8855286] Mol Cell Biol. 1997 Jan;17(1):24-35 [8972182] Cancer Lett. 1997 Jan 15;112(1):33-45 [9029167] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3302-7 [9096388] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma. AN - 68060951; 16765702 AB - To detect Chlamydia pneumoniae (C. pneumoniae) gene in a patient with bilateral orbital musoca-associated lymphoid tissue (MALT) lymphoma. Interventional case report. A 47-year-old Chinese man with recurrent bilateral orbital masses underwent surgical biopsy. Ophthalmologic and radiographic examinations, routine histology, immunohistochemistry, and molecular analysis for immunoglobulin heavy chain (IgH), bcl-2/IgH gene translocation, and Chlamydia genes were performed. Pathology revealed orbital MALT lymphoma with B-cell monoclonality. In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma. The finding of C. pneumoniae molecular signatures in this case suggests a possible association of Chlamydia and orbital MALT lymphoma. The infection may contribute to the development of the lymphoma. JF - American journal of ophthalmology AU - Shen, Defen AU - Yuen, Hunter K L AU - Galita, Dan A AU - Chan, Nongnart R AU - Chan, Chi-Chao AD - Laboratory of Immunology, National Institutes of Health, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1162 EP - 1163 VL - 141 IS - 6 SN - 0002-9394, 0002-9394 KW - Antineoplastic Agents, Alkylating KW - 0 KW - DNA, Bacterial KW - Glucocorticoids KW - Immunoglobulin Heavy Chains KW - Proto-Oncogene Proteins c-bcl-2 KW - Chlorambucil KW - 18D0SL7309 KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Genes, Bacterial KW - Prednisone -- therapeutic use KW - Humans KW - Tomography, X-Ray Computed KW - Gene Rearrangement KW - Chlorambucil -- therapeutic use KW - DNA, Bacterial -- analysis KW - Immunoglobulin Heavy Chains -- genetics KW - Polymerase Chain Reaction KW - Genes, Immunoglobulin -- genetics KW - Middle Aged KW - Glucocorticoids -- therapeutic use KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Male KW - Orbital Neoplasms -- microbiology KW - Orbital Neoplasms -- pathology KW - Eye Infections, Bacterial -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- microbiology KW - Eye Infections, Bacterial -- diagnostic imaging KW - Chlamydophila Infections -- pathology KW - Chlamydophila Infections -- diagnostic imaging KW - Lymphoma, B-Cell, Marginal Zone -- pathology KW - Lymphoma, B-Cell, Marginal Zone -- diagnostic imaging KW - Eye Infections, Bacterial -- pathology KW - Chlamydophila Infections -- microbiology KW - Orbital Neoplasms -- diagnostic imaging KW - Chlamydophila pneumoniae -- isolation & purification KW - Chlamydophila pneumoniae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68060951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+ophthalmology&rft.atitle=Detection+of+Chlamydia+pneumoniae+in+a+bilateral+orbital+mucosa-associated+lymphoid+tissue+lymphoma.&rft.au=Shen%2C+Defen%3BYuen%2C+Hunter+K+L%3BGalita%2C+Dan+A%3BChan%2C+Nongnart+R%3BChan%2C+Chi-Chao&rft.aulast=Shen&rft.aufirst=Defen&rft.date=2006-06-01&rft.volume=141&rft.issue=6&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=American+journal+of+ophthalmology&rft.issn=00029394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-06 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histol Histopathol. 2004 Oct;19(4):1219-26 [15375765] Acta Oncol. 1991;30(3):335-8 [2036243] Ophthalmology. 2003 Jun;110(6):1245-54 [12799255] J Natl Cancer Inst. 2004 Apr 21;96(8):586-94 [15100336] Med Clin North Am. 2005 Mar;89(2):313-44, viii [15656929] Am J Ophthalmol. 2005 Oct;140(4):729-30 [16226528] Blood. 2006 Jan 15;107(2):467-72 [16166588] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450. AN - 68054160; 16545970 AB - Endogenously generated nitric oxide (NO) mediates a host of important physiological functions, playing roles in the vascular, immunological, and neurological systems. As a result, exogenous agents that release NO have become important therapeutic interventions and research tools. O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) is a prodrug designed with the hypothesis that it might release nitric oxide via epoxidation of the vinyl group by cytochrome P450, followed by enzymatic and/or spontaneous epoxide hydration to release the ultimate NO-donating moiety, 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (PYRRO/NO) ion. In this study, we investigated this hypothetical activation mechanism quantitatively for V-PYRRO/NO using cDNA-expressed human cytochrome P450 (CYP)2E1. Incubation with CYP2E1 and an NADPH-regenerating system resulted in a time-dependent decomposition of V-PYRRO/NO, with a turnover rate of 2.0 nmol/min/pmol CYP2E1. Nitrate and nitrite were detected in high yield as metabolites of NO. The predicted organic metabolites pyrrolidine and glycolaldehyde were also detected in near-quantitative yields. The enzymatic decomposition of V-PYRRO/NO was also catalyzed, albeit at lower rates, by CYP2A6 and CYP2B6. We conclude that the initial step in the metabolism of V-PYRRO/NO to NO in the liver is catalyzed efficiently but not exclusively by the alcohol-inducible form of cytochrome P450 (CYP2E1). The results confirm the proposed activation mechanism involving enzymatic oxidation of the vinyl group in V-PYRRO/NO followed by epoxide hydration and hydrolytic decomposition of the resulting PYRRO/NO ion to generate nitric oxide. JF - Nitric oxide : biology and chemistry AU - Inami, Keiko AU - Nims, Raymond W AU - Srinivasan, Aloka AU - Citro, Michael L AU - Saavedra, Joseph E AU - Cederbaum, Arthur I AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 309 EP - 315 VL - 14 IS - 4 SN - 1089-8603, 1089-8603 KW - DNA, Complementary KW - 0 KW - Nitrates KW - Nitrites KW - O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate KW - Pyrrolidines KW - Nitric Oxide KW - 31C4KY9ESH KW - NADP KW - 53-59-8 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2A6 protein, human KW - CYP2B6 protein, human KW - Cytochrome P-450 CYP2A6 KW - Cytochrome P-450 CYP2B6 KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Acetaldehyde KW - GO1N1ZPR3B KW - glycolaldehyde KW - W0A0XPU08U KW - Index Medicus KW - Acetaldehyde -- analogs & derivatives KW - Nitrites -- metabolism KW - Humans KW - Nitrates -- metabolism KW - NADP -- metabolism KW - Acetaldehyde -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Mixed Function Oxygenases -- metabolism KW - DNA, Complementary -- metabolism KW - Kinetics KW - Oxidoreductases, N-Demethylating -- metabolism KW - Catalysis KW - Liver -- enzymology KW - Liver -- drug effects KW - Pyrrolidines -- pharmacology KW - Nitric Oxide -- metabolism KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Pyrrolidines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68054160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Metabolism+of+a+liver-selective+nitric+oxide-releasing+agent%2C+V-PYRRO%2FNO%2C+by+human+microsomal+cytochromes+P450.&rft.au=Inami%2C+Keiko%3BNims%2C+Raymond+W%3BSrinivasan%2C+Aloka%3BCitro%2C+Michael+L%3BSaavedra%2C+Joseph+E%3BCederbaum%2C+Arthur+I%3BKeefer%2C+Larry+K&rft.aulast=Inami&rft.aufirst=Keiko&rft.date=2006-06-01&rft.volume=14&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=10898603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methodology of clinical trials with new molecular-targeted agents: where do we stand? AN - 68049144; 16760275 AB - In recent years, we have witnessed growing interest in the methodology of clinical trials with molecular-targeted agents. In phase I studies, alternative end points to toxicity have been proposed to define the optimal biological dose: the identification of a 'target effect', the measurement of 'surrogates' for biological activity and the assessment of drug plasma levels. However, these end points are not routinely incorporated into the study design and have rarely formed the primary basis for dose selection. In phase II studies, response rate remains the preferred end point in the early evaluation of new drugs. However, this approach might lead to rejection of potentially useful drugs when significant tumor shrinkage cannot be demonstrated. Therefore, a number of alternative end points have been proposed for agents that are not expected to cause a major tumor regression: time to progression, progression-free survival, overall survival, early progression rate and growth modulation index. In phase III trials, where efficacy in terms of survival remains the most important goal of the research, the major issues are the adequate selection of patients and the optimal clinical setting of evaluation of drugs. In conclusion, many important questions regarding the methodology of clinical research with target-based agents remain open and need to be defined by research in the near future. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Morabito, A AU - Di Maio, M AU - De Maio, E AU - Normanno, N AU - Perrone, F AD - Clinical Trials Unit, National Cancer Institute, Napoli, Italy. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - vii128 EP - vii131 VL - 17 Suppl 7 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Clinical Trials, Phase I as Topic -- methods KW - Humans KW - Clinical Trials, Phase III as Topic -- methods KW - Clinical Trials, Phase II as Topic -- methods KW - Antineoplastic Agents -- therapeutic use KW - Clinical Trials as Topic -- methods KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68049144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Methodology+of+clinical+trials+with+new+molecular-targeted+agents%3A+where+do+we+stand%3F&rft.au=Morabito%2C+A%3BDi+Maio%2C+M%3BDe+Maio%2C+E%3BNormanno%2C+N%3BPerrone%2C+F&rft.aulast=Morabito&rft.aufirst=A&rft.date=2006-06-01&rft.volume=17+Suppl+7&rft.issue=&rft.spage=vii128&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A hitchhiker's guide to the NIEHS strategic plan. AN - 68042971; 16759966 JF - Environmental health perspectives AU - Schwartz, David A AD - david.schwartz@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - United States KW - Humans KW - Environmental Exposure KW - Education, Graduate KW - National Institutes of Health (U.S.) -- organization & administration KW - Planning Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68042971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+hitchhiker%27s+guide+to+the+NIEHS+strategic+plan.&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=A334&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: understanding sources of complexity in chronic diseases--the importance of integration of genetics and epidemiology. AN - 68040300; 16540533 JF - International journal of epidemiology AU - Merikangas, Kathleen Ries AU - Low, Nancy C P AU - Hardy, John AD - Section on Developmental Genetic Epidemiology, National Institutes of Health, National Institute of Mental Health, 35 Convent Drive, MSC#3720, Bethesda, MD 20892, USA. merikangas@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 590 EP - 2; discussion 593-6 VL - 35 IS - 3 SN - 0300-5771, 0300-5771 KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Genetic Diseases, Inborn -- genetics KW - Environmental Exposure -- adverse effects KW - Chronic Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68040300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fish+%26+Shellfish+Immunology&rft.atitle=Molecular+cloning+and+characterisation+of+peroxinectin%2C+a+cell+adhesion+molecule%2C+from+the+giant+freshwater+prawn+Macrobrachium+rosenbergii&rft.au=Hsu%2C+P+I%3BLiu%2C+CH%3BTseng%2C+D+Y%3BLee%2C+P+P%3BCheng%2C+W&rft.aulast=Hsu&rft.aufirst=P&rft.date=2006-07-01&rft.volume=21&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Fish+%26+Shellfish+Immunology&rft.issn=10504648&rft_id=info:doi/10.1016%2Fj.fsi.2005.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-12 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2006 Jun;35(3):562-71 [16540539] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. AN - 68034801; 16740776 AB - Thalidomide has gained renewed interest as a cancer therapeutic due to its potential antiangiogenic effects. The thalidomide analogues CPS11 and CPS49 are active in preclinical angiogenesis assays and xenograft model systems, but the biochemical basis for these observations is unclear. To address this question, we assessed the toxicity of these thalidomide analogues in cancer cells, endothelial cells, and genetically modified cells using assays that measure apoptotic and nonapoptotic cell death. Phosphospecific and native antibodies were used in immunoblotting and immunohistochemical experiments to assess the activation states of kinases that control cellular survival in vitro and in vivo. CPS49 predominantly induced nonapoptotic cell death in lung cancer cells, prostate cancer cells, and endothelial cells in a dose-dependent manner, whereas CPS11 was not cytotoxic. CPS49 did not inhibit kinases that promote survival, such as Akt or extracellular signal-regulated kinase, but rather rapidly activated the stress kinase p38 pathway in both cancer cells and endothelial cells. CPS49 activated p38 in tumor xenografts. Using p38alpha-/- cells or an inhibitor of p38, we show that the presence and activation of p38alpha is important for cytotoxicity in all cell types examined. Our studies identify a unifying mechanism of action for cytotoxicity of the tetraflourinated thalidomide analogue, CPS49, and suggest that activation of p38 could serve as a biomarker in clinical trials with CPS49. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Warfel, Noel A AU - Lepper, Erin R AU - Zhang, Chunyu AU - Figg, William D AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA. Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 3502 EP - 3509 VL - 12 IS - 11 Pt 1 SN - 1078-0432, 1078-0432 KW - Butadienes KW - 0 KW - CPS 49 KW - Enzyme Inhibitors KW - Imidazoles KW - Nitriles KW - Pyridines KW - U 0126 KW - Thalidomide KW - 4Z8R6ORS6L KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 14 KW - SB 203580 KW - OU13V1EYWQ KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Drug Screening Assays, Antitumor KW - Nitriles -- pharmacology KW - Imidazoles -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Cell Death -- drug effects KW - Extracellular Signal-Regulated MAP Kinases -- drug effects KW - Structure-Activity Relationship KW - Butadienes -- pharmacology KW - Xenograft Model Antitumor Assays KW - Enzyme Inhibitors -- pharmacology KW - Mice, SCID KW - Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors KW - Pyridines -- pharmacology KW - Endothelial Cells -- drug effects KW - Neoplasms -- pathology KW - Mitogen-Activated Protein Kinase 14 -- metabolism KW - Thalidomide -- antagonists & inhibitors KW - Thalidomide -- administration & dosage KW - Mitogen-Activated Protein Kinase 14 -- antagonists & inhibitors KW - Thalidomide -- pharmacology KW - Thalidomide -- analogs & derivatives KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68034801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Importance+of+the+stress+kinase+p38alpha+in+mediating+the+direct+cytotoxic+effects+of+the+thalidomide+analogue%2C+CPS49%2C+in+cancer+cells+and+endothelial+cells.&rft.au=Warfel%2C+Noel+A%3BLepper%2C+Erin+R%3BZhang%2C+Chunyu%3BFigg%2C+William+D%3BDennis%2C+Phillip+A&rft.aulast=Warfel&rft.aufirst=Noel&rft.date=2006-06-01&rft.volume=12&rft.issue=11+Pt+1&rft.spage=3502&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2006-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder. AN - 68034664; 16740845 AB - Our goal was to examine substance-use initiation in healthy adolescents and in adolescents who have been diagnosed with attention-deficit/hyperactivity disorder. Seventy-eight adolescents (28 healthy and 50 with attention-deficit/hyperactivity disorder) participated in an ongoing longitudinal study of predictors of substance use. The substances most commonly reported were tobacco, alcohol, and marijuana. Aggression, conduct problems, hyperactivity, impulsivity, inattention, anxiety/depression, social difficulties, and somatic complaints were assessed at study entry and tested as predictors for later substance use. With an average of 4 years into the study, 37 adolescents had not used any substances, 41 had experimented with at least 1 substance, and 29 experimented with >1 substance. Psychiatric diagnoses (attention-deficit/hyperactivity disorder, attention-deficit/hyperactivity disorder and conduct disorder, and attention-deficit/hyperactivity disorder and depression/anxiety) did not influence reports of substance use. Distinct behavioral measures collected at study entry predicted use of different substances. In a multivariate analysis, aggression had the greatest association with tobacco smoking and marijuana use. Impulsivity was associated with alcohol use. Severity of drug exposure, indexed by the number of substances used, was predicted by aggression. This 4-year longitudinal study captured the onset of substance use, not abuse. Behavioral predictors differed with the type of substance used. These behavioral characteristics may raise suspicion among pediatricians for enhanced risk for substance-use initiation. JF - Pediatrics AU - Ernst, Monique AU - Luckenbaugh, David A AU - Moolchan, Eric T AU - Leff, Michelle K AU - Allen, Rachel AU - Eshel, Neir AU - London, Edythe D AU - Kimes, Alane AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892-2670, USA. ernstm@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 2030 EP - 2039 VL - 117 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - Adolescent Behavior KW - Humans KW - Child KW - Longitudinal Studies KW - Adolescent KW - Male KW - Female KW - Attention Deficit Disorder with Hyperactivity -- complications KW - Substance-Related Disorders -- etiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68034664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Behavioral+predictors+of+substance-use+initiation+in+adolescents+with+and+without+attention-deficit%2Fhyperactivity+disorder.&rft.au=Ernst%2C+Monique%3BLuckenbaugh%2C+David+A%3BMoolchan%2C+Eric+T%3BLeff%2C+Michelle+K%3BAllen%2C+Rachel%3BEshel%2C+Neir%3BLondon%2C+Edythe+D%3BKimes%2C+Alane&rft.aulast=Ernst&rft.aufirst=Monique&rft.date=2006-06-01&rft.volume=117&rft.issue=6&rft.spage=2030&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-26 N1 - Date created - 2006-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. AN - 68033617; 16710476 AB - Identification of specific gene expression signatures characteristic of oncogenic pathways is an important step toward molecular classification of human malignancies. Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis. In this study, we defined the Met-dependent gene expression signature using global gene expression profiling of WT and Met-deficient primary mouse hepatocytes. Newly identified transcriptional targets of the Met pathway included genes involved in the regulation of oxidative stress responses as well as cell motility, cytoskeletal organization, and angiogenesis. To assess the importance of a Met-regulated gene expression signature, a comparative functional genomic approach was applied to 242 human hepatocellular carcinomas (HCCs) and 7 metastatic liver lesions. Cluster analysis revealed that a subset of human HCCs and all liver metastases shared the Met-induced expression signature. Furthermore, the presence of the Met signature showed significant correlation with increased vascular invasion rate and microvessel density as well as with decreased mean survival time of HCC patients. We conclude that the genetically defined gene expression signatures in combination with comparative functional genomics constitute an attractive paradigm for defining both the function of oncogenic pathways and the clinically relevant subgroups of human cancers. JF - The Journal of clinical investigation AU - Kaposi-Novak, Pal AU - Lee, Ju-Seog AU - Gòmez-Quiroz, Luis AU - Coulouarn, Cédric AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1582 EP - 1595 VL - 116 IS - 6 SN - 0021-9738, 0021-9738 KW - HGF protein, human KW - 0 KW - Proto-Oncogene Proteins KW - Receptors, Growth Factor KW - Hepatocyte Growth Factor KW - 67256-21-7 KW - MET protein, human KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-met KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Hepatocyte Growth Factor -- metabolism KW - Mice KW - Mice, Knockout KW - Phenotype KW - Gene Expression Profiling KW - Survival Rate KW - Cells, Cultured KW - Neoplasm Metastasis KW - Molecular Sequence Data KW - Middle Aged KW - Hepatocytes -- cytology KW - Hepatocytes -- physiology KW - Female KW - Male KW - Liver Neoplasms -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Liver Neoplasms -- diagnosis KW - Gene Expression Regulation, Neoplastic KW - Carcinoma, Hepatocellular -- metabolism KW - Liver Neoplasms -- pathology KW - Receptors, Growth Factor -- genetics KW - Carcinoma, Hepatocellular -- diagnosis KW - Receptors, Growth Factor -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Proto-Oncogene Proteins -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68033617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Met-regulated+expression+signature+defines+a+subset+of+human+hepatocellular+carcinomas+with+poor+prognosis+and+aggressive+phenotype.&rft.au=Kaposi-Novak%2C+Pal%3BLee%2C+Ju-Seog%3BG%C3%B2mez-Quiroz%2C+Luis%3BCoulouarn%2C+C%C3%A9dric%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Kaposi-Novak&rft.aufirst=Pal&rft.date=2006-06-01&rft.volume=116&rft.issue=6&rft.spage=1582&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Liver Dis. 2005;25(2):143-54 [15918143] Nature. 1995 Feb 23;373(6516):699-702 [7854452] Nat Genet. 2005 Jun;37 Suppl:S38-45 [15920529] Trends Mol Med. 2005 Jun;11(6):284-92 [15949770] Hepatology. 2005 Aug;42(2):353-61 [15965925] Cancer Gene Ther. 2006 Feb;13(2):115-24 [16138117] Nat Med. 2006 Apr;12(4):410-6 [16532004] Nat Genet. 2005 Jun;37 Suppl:S31-7 [15920528] Nat Cell Biol. 2002 Sep;4(9):720-4 [12198496] Cell. 2003 Feb 21;112(4):453-65 [12600310] Lancet. 2003 Mar 15;361(9361):923-9 [12648972] Clin Exp Metastasis. 2003;20(1):59-68 [12650608] J Biol Chem. 2003 Apr 4;278(14):12029-38 [12556532] Cancer Res. 2003 Apr 1;63(7):1576-82 [12670907] Nat Med. 2003 Apr;9(4):416-23 [12640447] Nat Genet. 2003 Jun;34(2):226-30 [12754511] Cancer Metastasis Rev. 2003 Dec;22(4):309-25 [12884908] Clin Cancer Res. 2000 Feb;6(2):480-7 [10690527] J Biol Chem. 2000 Mar 24;275(12):8806-11 [10722725] Oncogene. 2000 Nov 20;19(49):5582-9 [11114738] J Biol Chem. 2000 Dec 22;275(51):40134-41 [11013233] Cancer Res. 2001 Mar 1;61(5):2129-37 [11280777] Cancer Res. 2001 Aug 1;61(15):5861-8 [11479227] Nat Genet. 2001 Oct;29(2):143-52 [11544480] Mol Cell. 2002 Feb;9(2):411-21 [11864613] J Cell Sci. 2002 Apr 15;115(Pt 8):1591-601 [11950878] Nucleic Acids Res. 2002 May 1;30(9):e36 [11972351] Mol Biol Cell. 2002 Jun;13(6):1929-39 [12058060] Nature. 1995 Aug 31;376(6543):768-71 [7651534] Biochem Biophys Res Commun. 1996 May 6;222(1):64-70 [8630075] Science. 1997 Apr 4;276(5309):60-6 [9082986] Hepatology. 1997 Apr;25(4):862-6 [9096589] Nat Med. 1999 Feb;5(2):226-30 [9930873] Oncogene. 1999 Feb 4;18(5):1139-46 [10022119] Cancer Res. 1999 Aug 15;59(16):3954-60 [10463591] Trends Mol Med. 2004 Nov;10(11):549-57 [15519281] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Nat Genet. 2005 Jan;37(1):48-55 [15608639] J Biol Chem. 2005 Feb 4;280(5):3780-8 [15569684] J Biol Chem. 2005 Feb 18;280(7):5836-42 [15579908] Carcinogenesis. 2003 Aug;24(8):1353-9 [12807734] Br J Pharmacol. 2003 Oct;140(4):595-610 [14504135] J Cancer Res Clin Oncol. 2003 Jul;129(7):415-22 [14605882] Nat Rev Cancer. 2003 Nov;3(11):877-83 [14668818] Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25 [14685170] Cell Signal. 2004 Apr;16(4):505-13 [14709339] Hepatology. 2004 Mar;39(3):645-54 [14999683] Neoplasia. 2004 Jan-Feb;6(1):1-6 [15068665] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82 [15070743] Cancer Res. 2004 May 15;64(10):3701-13 [15150131] Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9309-14 [15184677] J Biol Chem. 2004 Jul 9;279(28):28970-8 [15123705] Anticancer Res. 2004 May-Jun;24(3a):1797-804 [15274358] Hepatology. 2004 Sep;40(3):667-76 [15349906] Int J Dev Biol. 2004;48(5-6):451-6 [15349819] Free Radic Biol Med. 2004 Oct 15;37(8):1152-9 [15451055] Nat Rev Mol Cell Biol. 2004 Oct;5(10):816-26 [15459662] J Surg Res. 2004 Oct;121(2):228-41 [15501463] Comment In: J Hepatol. 2007 Apr;46(4):748-9 [17275125] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. AN - 68021461; 16497704 AB - The field of cancer epigenetics has received much attention in recent years. However, the relationship of cancer epigenetics with cancer etiology is not clear. Recent studies suggest the involvement of altered DNA methylation and histone modifications in the emergence of epigenetically reprogrammed cells with specific tumor-related phenotypes at premalignant stages of tumor development. In this study, we used a methyl-deficient model of rodent hepatocarcinogenesis to examine the roles of DNA, histone H3 lysine 9 and histone H4 lysine 20 methylation, and the level of the expression of Suv39h1 and Suv4-20h2 histone methyltransferases in the carcinogenic process. We demonstrated that the development of liver tumors was characterized by progressive demethylation of DNA repeats, decrease in histone H4 lysine 20 trimethylation, and a gradual decrease in the expression of Suv4-20h2 histone methyltransferase. A prominent increase in the trimethylation of histone H3 lysine 9 and in the expression of Suv39h1 histone methyltransferase was observed in preneoplastic nodules and liver tumors indicating the promotional role of these epigenetic alterations at later stages of carcinogenesis. The appearance of tumor-specific epigenetic alterations (demethylation of repetitive elements, loss of histone H4 lysine 20 trimethylation, altered expression of Suv4-20h2 and Suv39h1 histone methyltransferases) at preneoplastic stages of hepatocarcinogenesis provides experimental support for the epigenetic hypothesis of tumorigenesis that considers stress-induced epigenetic reprogramming of the cell as an important prerequisite to succeeding mutations. JF - Carcinogenesis AU - Pogribny, Igor P AU - Ross, Sharon A AU - Tryndyak, Volodymyr P AU - Pogribna, Marta AU - Poirier, Lionel A AU - Karpinets, Tatiana V AD - National Center for Toxicological Research, Jefferson, AR 72078, National Cancer Institute, Bethesda, MD 20892 and University of Tennessee, Knoxville, TN 37996, USA. ipogribny@nctr.fda.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1180 EP - 1186 VL - 27 IS - 6 SN - 0143-3334, 0143-3334 KW - Histones KW - 0 KW - Repressor Proteins KW - Suv39h1 protein, mouse KW - EC 2.1.1. KW - Suv39h1 protein, rat KW - Methyltransferases KW - EC 2.1.1.- KW - Protein Methyltransferases KW - histone methyltransferase KW - Suv4-20h2 protein, rat KW - EC 2.1.1.125 KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Long Interspersed Nucleotide Elements KW - DNA Methylation KW - Epigenesis, Genetic KW - Mutation KW - Methylation KW - Male KW - Repressor Proteins -- biosynthesis KW - Liver Neoplasms -- metabolism KW - Histones -- metabolism KW - Histones -- chemistry KW - Methyltransferases -- chemistry KW - Methyltransferases -- biosynthesis KW - Histone-Lysine N-Methyltransferase -- chemistry KW - Repressor Proteins -- chemistry KW - Histone-Lysine N-Methyltransferase -- metabolism KW - Histone-Lysine N-Methyltransferase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68021461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Histone+H3+lysine+9+and+H4+lysine+20+trimethylation+and+the+expression+of+Suv4-20h2+and+Suv-39h1+histone+methyltransferases+in+hepatocarcinogenesis+induced+by+methyl+deficiency+in+rats.&rft.au=Pogribny%2C+Igor+P%3BRoss%2C+Sharon+A%3BTryndyak%2C+Volodymyr+P%3BPogribna%2C+Marta%3BPoirier%2C+Lionel+A%3BKarpinets%2C+Tatiana+V&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2006-06-01&rft.volume=27&rft.issue=6&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. AN - 68016437; 16361272 AB - There is evidence that chronic inflammation predisposes to biliary tract cancer and that use of non-steroidal anti-inflammatory drugs (NSAIDs) is protective. Although the mechanisms by which NSAIDs lower cancer risk remain unclear, NSAIDs reduce prostaglandin production by blocking prostaglandin-endoperoxide synthase 2 (PTGS2, commonly known as COX-2), an enzyme induced by proinflammatory stimuli that is often overexpressed in malignant tissue. Since variants in the PTGS2 gene may modify the expression or function of its encoded enzyme to modulate the inflammatory response in the biliary tract, we examined the associations of eight PTGS2 polymorphisms (-645C-->T; Ex3 -8G-->C; IVS5 -275T-->G; IVS7 +111T-->C; Ex10 +127T-->C; Ex10 +686 --->ATTAT-->TTATA; Ex10 +837T-->C; Ex10 -90C-->T) with biliary tract cancer and stones in a population-based case-control study conducted in Shanghai, China. Genotyping was performed for 411 patients with biliary tract cancer (237 gallbladder, 127 extrahepatic bile duct and 47 ampulla of Vater), 895 patients with biliary stones (673 gallbladder, 222 bile duct), and 786 healthy individuals randomly selected from the population. Significant associations were seen only between the Ex10 +837T-->C marker and bile duct cancer risk. Relative to individuals with the TT genotype, those carrying the C allele (TC or CC genotype) had a 1.8-fold (95% confidence interval: 1.2-2.7) risk of bile duct cancer. Inferred haplotypes including this risk-conferring allele were also associated with increased bile duct cancer risk of similar magnitude. Our results suggest that a common PTGS2 variant increases bile duct cancer risk. Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes. JF - Carcinogenesis AU - Sakoda, Lori C AU - Gao, Yu-Tang AU - Chen, Bingshu E AU - Chen, Jinbo AU - Rosenberg, Philip S AU - Rashid, Asif AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Cohen-Webb, Hope AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Fraumeni, Joseph F AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7234, USA. sokadal@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1251 EP - 1256 VL - 27 IS - 6 SN - 0143-3334, 0143-3334 KW - Membrane Proteins KW - 0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - DNA Glycosylases KW - EC 3.2.2.- KW - oxoguanine glycosylase 1, human KW - Index Medicus KW - Smoking KW - Age Factors KW - Genetics, Population KW - Humans KW - Cohort Studies KW - DNA Glycosylases -- genetics KW - Aged KW - Middle Aged KW - Male KW - Female KW - China KW - Polymorphism, Genetic KW - Cyclooxygenase 2 -- genetics KW - Biliary Tract Neoplasms -- genetics KW - Membrane Proteins -- genetics KW - Genetic Predisposition to Disease KW - Gallstones -- genetics KW - Gallstones -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68016437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Prostaglandin-endoperoxide+synthase+2+%28PTGS2%29+gene+polymorphisms+and+risk+of+biliary+tract+cancer+and+gallstones%3A+a+population-based+study+in+Shanghai%2C+China.&rft.au=Sakoda%2C+Lori+C%3BGao%2C+Yu-Tang%3BChen%2C+Bingshu+E%3BChen%2C+Jinbo%3BRosenberg%2C+Philip+S%3BRashid%2C+Asif%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BCohen-Webb%2C+Hope%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BFraumeni%2C+Joseph+F%3BHsing%2C+Ann+W&rft.aulast=Sakoda&rft.aufirst=Lori&rft.date=2006-06-01&rft.volume=27&rft.issue=6&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactions of cocaine with dopamine uptake inhibitors or dopamine releasers in rats discriminating cocaine. AN - 67997452; 16478825 AB - Several dopamine (DA) indirect agonists have been proposed as potential medications for treating cocaine abuse. The objective of the present study was to quantify the interactions among cocaine and DA uptake inhibitors or DA releasers to better understand how these drugs may be working when administered in combination. The DA uptake inhibitors GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]-ethyl}-4-(3-phenylpropyl)piperazine], WIN 35,428 [2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane], methylphenidate, indatraline, nomifensine, and mazindol and DA releasers methamphetamine, d-amphetamine, methcathinone, cathinone, fencamfamine, and phentermine were examined alone and in combination with cocaine in rats trained to discriminate cocaine (10 mg/kg i.p.) from saline injections. All of the DA indirect agonists dose-dependently substituted for cocaine and shifted the cocaine dose-effect curve leftward. Isobolographic analysis indicated the interactions were generally additive, although both methamphetamine and d-amphetamine were quantitatively determined to be more potent than DA uptake inhibitors in shifting the cocaine dose-effect function to the left. The potential of d-amphetamine as an effective treatment for cocaine abuse and negative clinical results with dopamine uptake inhibitors suggest that differences in shifts in dose-effect curves should be further examined with emerging clinical data as a predictive index of potential treatments for cocaine abuse. JF - The Journal of pharmacology and experimental therapeutics AU - Li, Su-Min AU - Campbell, Bettye L AU - Katz, Jonathan L AD - Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1088 EP - 1096 VL - 317 IS - 3 SN - 0022-3565, 0022-3565 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Male KW - Discrimination Learning -- drug effects KW - Dopamine -- metabolism KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67997452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Interactions+of+cocaine+with+dopamine+uptake+inhibitors+or+dopamine+releasers+in+rats+discriminating+cocaine.&rft.au=Li%2C+Su-Min%3BCampbell%2C+Bettye+L%3BKatz%2C+Jonathan+L&rft.aulast=Li&rft.aufirst=Su-Min&rft.date=2006-06-01&rft.volume=317&rft.issue=3&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-26 N1 - Date created - 2006-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. AN - 67991566; 16709819 AB - Activating, DAP12-coupled members of the Ly-49 family of NK cell receptors help control viral infections in mice. However, the kinases and/or phosphatases mediating tyrosine phosphorylation of Ly-49D-associated DAP12 have not been elucidated. In this study, we show for the first time that Src family tyrosine kinases are physically and functionally associated with Ly-49D/DAP12 signaling in murine NK cells. Specifically, we demonstrate the following: 1) inhibition of Src family kinases suppresses DAP12 phosphorylation and downstream DAP12 signals; 2) both Fyn and Lck are capable of phosphorylating DAP12; and 3) both kinases coimmunoprecipitate with the Ly-49D/DAP12 complex in NK cells. Although we detect enhanced phosphorylation of Fyn upon Ly-49D cross-linking in NK cells, Ly-49D-mediated events in both Fyn-/- and Fyn/Lck-/- mice appear normal, reinforcing the theme of redundancy in the ability of Src family kinases to initiate activation events. In contrast to disruption of specific Src family enzymes, Ly-49D/DAP12-mediated calcium mobilization and cytokine production by CD45 null NK cells are defective. Although others have ascribed the effects of CD45 mutation solely on the suppression of Src family activity, we demonstrate in this study that DAP12 is hyperphosphorylated in CD45 null NK cells, resulting in uncoordinated tyrosine-mediated signaling upon Ly-49D ligation. Therefore, although our data are consistent with a Src kinase activity proximally within DAP12 signaling, DAP12 also appears to be a substrate of CD45, suggesting a more complex role for this phosphatase than has been reported previously. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Mason, Llewellyn H AU - Willette-Brown, Jami AU - Taylor, Lynn S AU - McVicar, Daniel W AD - Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA. Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 6615 EP - 6623 VL - 176 IS - 11 SN - 0022-1767, 0022-1767 KW - AG 1879 KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Antibodies, Monoclonal KW - Antigens, Ly KW - Cross-Linking Reagents KW - Intracellular Signaling Peptides and Proteins KW - Klra4 protein, mouse KW - Lectins, C-Type KW - NK Cell Lectin-Like Receptor Subfamily A KW - Pyrimidines KW - Receptors, NK Cell Lectin-Like KW - Tyrobp protein, mouse KW - Tyrosine KW - 42HK56048U KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Fyn protein, mouse KW - EC 2.7.10.2 KW - Lymphocyte Specific Protein Tyrosine Kinase p56(lck) KW - Proto-Oncogene Proteins c-fyn KW - SYK protein, human KW - Syk Kinase KW - Syk protein, mouse KW - src-Family Kinases KW - Antigens, CD45 KW - EC 3.1.3.48 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Cross-Linking Reagents -- metabolism KW - Proto-Oncogene Proteins c-fyn -- deficiency KW - Killer Cells, Natural -- enzymology KW - Mice, Knockout KW - Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors KW - Phosphorylation KW - Lymphocyte Specific Protein Tyrosine Kinase p56(lck) -- physiology KW - Tyrosine -- metabolism KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Antibodies, Monoclonal -- metabolism KW - Pyrimidines -- pharmacology KW - Down-Regulation -- immunology KW - Mice KW - Proto-Oncogene Proteins c-fyn -- genetics KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Proto-Oncogene Proteins c-fyn -- physiology KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Cytotoxicity Tests, Immunologic KW - Killer Cells, Natural -- metabolism KW - Killer Cells, Natural -- immunology KW - Cell Line KW - Protein-Tyrosine Kinases -- physiology KW - Adaptor Proteins, Signal Transducing -- physiology KW - Antigens, Ly -- immunology KW - Lectins, C-Type -- immunology KW - Lectins, C-Type -- metabolism KW - Antigens, CD45 -- genetics KW - Adaptor Proteins, Signal Transducing -- antagonists & inhibitors KW - src-Family Kinases -- antagonists & inhibitors KW - src-Family Kinases -- physiology KW - Antigens, Ly -- physiology KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Lectins, C-Type -- physiology KW - Antigens, Ly -- metabolism KW - Signal Transduction -- immunology KW - Antigens, CD45 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67991566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Regulation+of+Ly49D%2FDAP12+signal+transduction+by+Src-family+kinases+and+CD45.&rft.au=Mason%2C+Llewellyn+H%3BWillette-Brown%2C+Jami%3BTaylor%2C+Lynn+S%3BMcVicar%2C+Daniel+W&rft.aulast=Mason&rft.aufirst=Llewellyn&rft.date=2006-06-01&rft.volume=176&rft.issue=11&rft.spage=6615&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2006-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. AN - 67984072; 16705172 AB - Lymphotoxin alpha (LTalpha) can exist in soluble form and exert tumor necrosis factor (TNF)-like activity through TNF receptors. Based on the phenotypes of knockout (KO) mice, the physiological functions of LTalpha and TNF are considered partly redundant, in particular, in supporting the microarchitecture of the spleen and in host defense. We exploited Cre-LoxP technology to generate a novel neomycin resistance gene (neo) cassette-free LTalpha-deficient mouse strain (neo-free LTalpha KO [LTalphaDelta/Delta]). Unlike the "conventional" LTalpha-/- mice, new LTalphaDelta/Delta animals were capable of producing normal levels of systemic TNF upon lipopolysaccharide (LPS) challenge and were susceptible to LPS/D-galactosamine (D-GalN) toxicity. Activated neutrophils, monocytes, and macrophages from LTalphaDelta/Delta mice expressed TNF normally at both the mRNA and protein levels as opposed to conventional LTalpha KO mice, which showed substantial decreases in TNF. Additionally, the spleens of the neo-free LTalpha KO mice displayed several features resembling those of LTbeta KO mice rather than conventional LTalpha KO animals. The phenotype of the new LTalphaDelta/Delta mice indicates that LTalpha plays a smaller role in lymphoid organ maintenance than previously thought and has no direct role in the regulation of TNF expression. JF - Molecular and cellular biology AU - Liepinsh, Dmitry J AU - Grivennikov, Sergei I AU - Klarmann, Kimberly D AU - Lagarkova, Maria A AU - Drutskaya, Marina S AU - Lockett, Stephen J AU - Tessarollo, Lino AU - McAuliffe, Matthew AU - Keller, Jonathan R AU - Kuprash, Dmitry V AU - Nedospasov, Sergei A AD - Basic Research Program, SAIC-Frederick, Inc., NCI--Frederick, Frederick, Maryland 21702, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 4214 EP - 4225 VL - 26 IS - 11 SN - 0270-7306, 0270-7306 KW - Lipopolysaccharides KW - 0 KW - Lymphotoxin-alpha KW - Tumor Necrosis Factor-alpha KW - Neomycin KW - 1404-04-2 KW - Ovalbumin KW - 9006-59-1 KW - Freund's Adjuvant KW - 9007-81-2 KW - Index Medicus KW - Ovalbumin -- immunology KW - Animals KW - CD4-Positive T-Lymphocytes -- cytology KW - Immunity, Innate -- immunology KW - Spleen -- cytology KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice KW - Lymphoid Tissue -- immunology KW - Freund's Adjuvant -- immunology KW - Mice, Knockout KW - Lipopolysaccharides -- immunology KW - Antibody Formation -- immunology KW - Mice, Inbred C57BL KW - Myeloid Cells -- immunology KW - Lymphotoxin-alpha -- genetics KW - Lymphotoxin-alpha -- deficiency KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Tumor Necrosis Factor-alpha -- metabolism KW - Lymphotoxin-alpha -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67984072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Novel+lymphotoxin+alpha+%28LTalpha%29+knockout+mice+with+unperturbed+tumor+necrosis+factor+expression%3A+reassessing+LTalpha+biological+functions.&rft.au=Liepinsh%2C+Dmitry+J%3BGrivennikov%2C+Sergei+I%3BKlarmann%2C+Kimberly+D%3BLagarkova%2C+Maria+A%3BDrutskaya%2C+Marina+S%3BLockett%2C+Stephen+J%3BTessarollo%2C+Lino%3BMcAuliffe%2C+Matthew%3BKeller%2C+Jonathan+R%3BKuprash%2C+Dmitry+V%3BNedospasov%2C+Sergei+A&rft.aulast=Liepinsh&rft.aufirst=Dmitry&rft.date=2006-06-01&rft.volume=26&rft.issue=11&rft.spage=4214&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-23 N1 - Date created - 2006-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Immunol. 2004 Oct;5(10):987-95 [15454922] Infect Immun. 2005 Aug;73(8):4787-92 [16040991] Science. 1985 Aug 30;229(4716):869-71 [3895437] Nature. 1987 Jan 15-21;325(6101):265-7 [3027565] Infect Immun. 1988 Oct;56(10):2563-9 [3138177] J Exp Med. 1990 Jan 1;171(1):35-47 [2104921] J Immunol. 1991 Jul 1;147(1):22-8 [1711076] Infect Immun. 1992 Mar;60(3):951-7 [1541569] Cell. 1993 Mar 26;72(6):847-56 [7916655] Cell. 1993 May 7;73(3):457-67 [8387893] J Immunol. 1993 Aug 1;151(3):1548-61 [8393046] J Exp Med. 1994 Jan 1;179(1):259-68 [8270870] J Immunol. 1999 Dec 15;163(12):6575-80 [10586051] Annu Rev Immunol. 2001;19:93-129 [11244032] J Exp Med. 2001 Jan 15;193(2):239-46 [11208864] Eur J Immunol. 2001 Jun;31(6):1935-43 [11433391] Mol Cell Biol. 2002 Apr;22(8):2620-31 [11909956] Mol Cell Biol. 2002 Dec;22(24):8626-34 [12446781] Blood. 2003 Feb 15;101(4):1477-83 [12560241] Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):181-4 [12787557] J Immunol. 2003 Jun 15;170(12):6172-82 [12794148] Genesis. 2003 Jul;36(3):149-57 [12872246] Nat Rev Immunol. 2003 Sep;3(9):745-56 [12949498] Nat Rev Immunol. 2003 Aug;3(8):642-55 [12974479] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Science. 1994 Apr 29;264(5159):703-7 [8171322] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):674-8 [7846035] Immunity. 1995 Jun;2(6):561-72 [7540941] J Immunol. 1995 Jul 15;155(2):674-83 [7608544] J Immunol. 1995 Aug 15;155(4):1685-93 [7636227] J Immunol Methods. 1996 Oct 16;197(1-2):139-50 [8890901] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13090-5 [8917549] FEMS Immunol Med Microbiol. 1996 Dec 1;16(2):83-104 [8988390] J Exp Med. 1997 Jun 16;185(12):2111-20 [9182683] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8093-8 [9223320] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9302-7 [9256477] J Immunol. 1998 Jan 15;160(2):943-52 [9551933] J Exp Med. 1998 May 4;187(9):1517-28 [9565643] Immunity. 1998 Jul;9(1):59-70 [9697836] J Biol Chem. 1998 Aug 14;273(33):21178-86 [9694874] J Exp Med. 1998 Aug 17;188(4):745-54 [9705956] Mol Cell Biol. 1998 Oct;18(10):5678-89 [9742085] J Exp Med. 1999 Jan 18;189(2):403-12 [9892622] J Immunol. 1999 Apr 1;162(7):4045-52 [10201927] Annu Rev Immunol. 1999;17:399-433 [10358764] Immunity. 2005 Jan;22(1):93-104 [15664162] Annu Rev Immunol. 2005;23:787-819 [15771586] Immunology. 2005 May;115(1):1-20 [15819693] Eur J Immunol. 2005 May;35(5):1592-600 [15832287] Proc Natl Acad Sci U S A. 1979 Nov;76(11):5939-43 [293694] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. AN - 67979288; 16690809 AB - The synthetic estrogen diethylstilbestrol (DES) is a potent perinatal endocrine disruptor. In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estrogen target tissues and results in long-term abnormalities such as uterine neoplasia that are not manifested until later in life. Using the developmentally exposed DES mouse, multiple mechanisms have been identified that play a role in its carcinogenic and toxic effects. Analysis of the DES murine uterus reveals altered gene expression pathways that include an estrogen-regulated component. Thus, perinatal DES exposure, especially at low doses, offers the opportunity to study effects caused by weaker environmental estrogens and provides an example of the emerging scientific field termed the developmental origin of adult disease. As a model endocrine disruptor, it is of particular interest that even low doses of DES increase uterine tumor incidence. Additional studies have verified that DES is not unique; when other environmental estrogens are tested at equal estrogenic doses, developmental exposure results in increased incidence of uterine neoplasia similar to that caused by DES. Interestingly, our data suggest that this increased susceptibility for tumors is passed on from the maternal lineage to subsequent generations of male and female descendants; the mechanisms involved in these transgenerational events include genetic and epigenetic events. Together, our data point out the unique sensitivity of the developing organism to endocrine-disrupting chemicals, the occurrence of long-term effects after developmental exposure, and the possibility for adverse effects to be transmitted to subsequent generations. JF - Endocrinology AU - Newbold, Retha R AU - Padilla-Banks, Elizabeth AU - Jefferson, Wendy N AD - Developmental Endocrinology and Endocrine Disruptor Section, Mail-Drop E4-02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. newbold1@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - S11 EP - S17 VL - 147 IS - 6 Suppl SN - 0013-7227, 0013-7227 KW - Endocrine Disruptors KW - 0 KW - Estrogens KW - Diethylstilbestrol KW - 731DCA35BT KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Uterine Neoplasms -- chemically induced KW - Humans KW - Infant, Newborn KW - Genital Neoplasms, Male -- chemically induced KW - Genital Neoplasms, Male -- genetics KW - Estrogens -- toxicity KW - Pregnancy KW - Epigenesis, Genetic -- drug effects KW - Environmental Exposure KW - Male KW - Female KW - Prenatal Exposure Delayed Effects KW - Genital Neoplasms, Female -- chemically induced KW - Genital Neoplasms, Female -- genetics KW - Endocrine Disruptors -- toxicity KW - Diethylstilbestrol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67979288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Adverse+effects+of+the+model+environmental+estrogen+diethylstilbestrol+are+transmitted+to+subsequent+generations.&rft.au=Newbold%2C+Retha+R%3BPadilla-Banks%2C+Elizabeth%3BJefferson%2C+Wendy+N&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2006-06-01&rft.volume=147&rft.issue=6+Suppl&rft.spage=S11&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function. AN - 67979171; 16690802 AB - The term endocrine-disrupting chemicals is used to define a structurally diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations. Research on these compounds has revealed that they use a variety of both nuclear receptor-mediated and non-receptor-mediated mechanisms to modulate different components of the endocrine system. This review will describe in vitro and in vivo studies that highlight the spectrum of unique mechanisms of action and biological effects of four endocrine-disrupting chemicals--diethylstilbestrol, genistein, di(n-butyl)phthalate, and methoxyacetic acid--to illustrate the diverse and complex nature of this class of compounds. JF - Endocrinology AU - Henley, Derek V AU - Korach, Kenneth S AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/06// PY - 2006 DA - June 2006 SP - S25 EP - S32 VL - 147 IS - 6 Suppl SN - 0013-7227, 0013-7227 KW - Acetates KW - 0 KW - Endocrine Disruptors KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Estrogen KW - Dibutyl Phthalate KW - 2286E5R2KE KW - Diethylstilbestrol KW - 731DCA35BT KW - Genistein KW - DH2M523P0H KW - methoxyacetic acid KW - F11T1H7Q7W KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Animals KW - Receptors, Estrogen -- drug effects KW - Genitalia, Female -- drug effects KW - Genitalia, Male -- drug effects KW - Humans KW - Diethylstilbestrol -- toxicity KW - Genistein -- toxicity KW - Dibutyl Phthalate -- toxicity KW - Acetates -- pharmacology KW - Genistein -- pharmacology KW - Receptors, Cytoplasmic and Nuclear -- drug effects KW - Diethylstilbestrol -- pharmacology KW - Dibutyl Phthalate -- pharmacology KW - Acetates -- toxicity KW - Male KW - Female KW - Endocrine Disruptors -- pharmacology KW - Endocrine System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67979171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Endocrine-disrupting+chemicals+use+distinct+mechanisms+of+action+to+modulate+endocrine+system+function.&rft.au=Henley%2C+Derek+V%3BKorach%2C+Kenneth+S&rft.aulast=Henley&rft.aufirst=Derek&rft.date=2006-06-01&rft.volume=147&rft.issue=6+Suppl&rft.spage=S25&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating the effect of help-seeking on achieving recovery from alcohol dependence. AN - 67960396; 16696626 AB - To investigate the effect of help-seeking on the likelihood of recovery from Diagnostic and Statistical Manual version IV (DSM-IV) alcohol dependence, specifically examining the impact of model selection, factors that moderate the effect of help-seeking and distinctions between the effects of 12-Step participation and formal treatment. This analysis is based on data from the Wave 1 2001-02 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a cross-sectional, retrospective survey of a nationally representative sample of US adults 18 years of age and over. The analytical sample consisted of 4422 individuals with prior-to-past-year (PPY) onset of DSM-IV alcohol dependence. Logistic regression, proportional hazards and time-dependent proportional hazards models were used to estimate the effects of help-seeking on three outcomes: (1) any recovery from alcohol dependence, which required full remission of all symptoms of alcohol abuse and dependence and excluded asymptomatic drinkers whose alcohol consumption exceeded low-risk drinking guidelines; (2) non-abstinent recovery (NR), representing low-risk asymptomatic drinkers; and (3) abstinent recovery (AR), representing abstainers. Only one-quarter of individuals with PPY-onset alcohol dependence had ever sought help for alcohol problems, including 3.1% who had participated in 12-Step programs only, 5.4% who had received formal treatment only and 17.0% with both 12-Step and formal treatment. Based on the most appropriate model, help-seeking increased the likelihood of any recovery [hazard rate ratio (HRR) = 2.38], NR (HRR = 1.50) and AR (HRR = 4.01). The impact of help-seeking on AR did not show any significant variation across the exposure period but was modified by severity among other factors. Individuals who participated in 12-Step programs in addition to formal treatment had almost twice the chance of recovery and more than more than twice the chance of AR compared with those who received formal treatment alone. Help-seeking plays a significant role in the achievement of abstinent recovery from alcohol dependence, with 12-Step participation playing a major role. Appropriate model selection is critical to assessing the impact of help-seeking. JF - Addiction (Abingdon, England) AU - Dawson, Deborah A AU - Grant, Bridget F AU - Stinson, Frederick S AU - Chou, Patricia S AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. ddawson@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 824 EP - 834 VL - 101 IS - 6 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Adult KW - Treatment Outcome KW - Temperance KW - Adolescent KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcoholism -- rehabilitation KW - Patient Acceptance of Health Care -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67960396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Estimating+the+effect+of+help-seeking+on+achieving+recovery+from+alcohol+dependence.&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BStinson%2C+Frederick+S%3BChou%2C+Patricia+S&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2006-06-01&rft.volume=101&rft.issue=6&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-21 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genomes to aid in bioremediation of dry cleaning solvents, mothballs and more. AN - 67958689; 16689716 JF - Environmental microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. galperin@ncbi.nlm.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 949 EP - 955 VL - 8 IS - 6 SN - 1462-2912, 1462-2912 KW - Environmental Pollutants KW - 0 KW - Naphthalenes KW - Solvents KW - naphthalene KW - 2166IN72UN KW - Index Medicus KW - Proteobacteria -- genetics KW - Naphthalenes -- metabolism KW - Proteobacteria -- metabolism KW - Biodegradation, Environmental KW - Laundering KW - Bacteria -- metabolism KW - Bacteria -- genetics KW - Environmental Pollutants -- metabolism KW - Genome, Bacterial KW - Solvents -- metabolism KW - Archaea -- metabolism KW - Archaea -- genetics KW - Genome, Archaeal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67958689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+microbiology&rft.atitle=Genomes+to+aid+in+bioremediation+of+dry+cleaning+solvents%2C+mothballs+and+more.&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-06-01&rft.volume=8&rft.issue=6&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Environmental+microbiology&rft.issn=14622912&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects. AN - 67924338; 16652279 AB - To differentiate between the effects that antiretroviral drugs have on the endothelium and the secondary effects that they have on immune function, viral load, and dyslipidemia, 6 non-human immunodeficiency virus-infected human subjects were treated with lopinavir-ritonavir for 1 month and, on the basis of forearm blood flow, the treatment's effects on endothelial cell function were measured. Surprisingly, after exposure to lopinavir-ritonavir, absolute forearm blood-flow responses to the endothelium-dependent vasodilator, acetylcholine, increased significantly (P=.03), and forearm blood flow decreased to a greater extent during specific inhibition of NO synthase by N(G)-monomethyl-L-arginine. Thus, in this small cohort of subjects, short-term treatment with lopinavir-ritonavir does not appear to directly promote endothelial cell dysfunction. JF - The Journal of infectious diseases AU - Grubb, Jessica R AU - Dejam, André AU - Voell, Jocelyn AU - Blackwelder, William C AU - Sklar, Peter A AU - Kovacs, Joseph A AU - Cannon, Richard O AU - Masur, Henry AU - Gladwin, Mark T AD - Critical Care Medical Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 1516 EP - 1519 VL - 193 IS - 11 SN - 0022-1899, 0022-1899 KW - Enzyme Inhibitors KW - 0 KW - HIV Protease Inhibitors KW - Pyrimidinones KW - Lopinavir KW - 2494G1JF75 KW - omega-N-Methylarginine KW - 27JT06E6GR KW - Acetylcholine KW - N9YNS0M02X KW - Ritonavir KW - O3J8G9O825 KW - Abridged Index Medicus KW - Index Medicus KW - Forearm -- blood supply KW - Acetylcholine -- administration & dosage KW - omega-N-Methylarginine -- administration & dosage KW - Enzyme Inhibitors -- administration & dosage KW - Humans KW - Acetylcholine -- pharmacology KW - Regional Blood Flow KW - Endothelium, Vascular -- physiology KW - Endothelium, Vascular -- drug effects KW - Adult KW - Enzyme Inhibitors -- pharmacology KW - omega-N-Methylarginine -- pharmacology KW - Female KW - Male KW - Pyrimidinones -- administration & dosage KW - Endothelial Cells -- drug effects KW - Endothelial Cells -- physiology KW - Pyrimidinones -- adverse effects KW - Ritonavir -- administration & dosage KW - HIV Protease Inhibitors -- adverse effects KW - Ritonavir -- adverse effects KW - HIV Protease Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67924338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Lopinavir-ritonavir%3A+effects+on+endothelial+cell+function+in+healthy+subjects.&rft.au=Grubb%2C+Jessica+R%3BDejam%2C+Andr%C3%A9%3BVoell%2C+Jocelyn%3BBlackwelder%2C+William+C%3BSklar%2C+Peter+A%3BKovacs%2C+Joseph+A%3BCannon%2C+Richard+O%3BMasur%2C+Henry%3BGladwin%2C+Mark+T&rft.aulast=Grubb&rft.aufirst=Jessica&rft.date=2006-06-01&rft.volume=193&rft.issue=11&rft.spage=1516&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Progress assessment in Chinese distance education: the voices of learners. AN - 57662372; 481817 AB - Progress assessment aims to assess students' performance and progress during a course of study. Its purpose is primarily developmental - to help students improve learning. Progress assessment is of special value in distance education in that it can motivate or pace distance learners throughout their course of study. It can help the tutor monitor the learning process of distance learners, diagnose their problems and provide prompt help and support. However, few empirical studies have been reported in the literature that address the issue of progress assessment from the perspective of Chinese distance learners. This paper investigates the perceptions of Chinese distance learners with regard to the necessity of progress assessment and the way it is being implemented in practice. (Author abstract) JF - Open Learning: The Journal of Open and Distance Learning AU - Jian, Niu AU - Hamp-Lyons, Liz AD - China Central Radio and Television University, 160 Fuxingmen Nei Dajie, Beijing 100031, P. R. China niujian@crtvu.edu.cn Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 111 EP - 123 PB - Taylor & Francis VL - 21 IS - 2 SN - 0268-0513, 0268-0513 KW - Distance learning KW - Education KW - Teaching KW - Chinese People's Republic KW - Students KW - 17.11: EDUCATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57662372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open+Learning%3A+The+Journal+of+Open+and+Distance+Learning&rft.atitle=Progress+assessment+in+Chinese+distance+education%3A+the+voices+of+learners.&rft.au=Jian%2C+Niu%3BHamp-Lyons%2C+Liz&rft.aulast=Jian&rft.aufirst=Niu&rft.date=2006-06-01&rft.volume=21&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Open+Learning%3A+The+Journal+of+Open+and+Distance+Learning&rft.issn=02680513&rft_id=info:doi/10.1080%2F02680510600713094 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Education; Teaching; Distance learning; Students; Chinese People's Republic DO - http://dx.doi.org/10.1080/02680510600713094 ER - TY - JOUR T1 - Validity of a Sun Safety Diary Using UV Monitors in Middle School Children AN - 57071386; 200619395 AB - This article describes a validity study conducted among middle school students comparing self-reported sun safety behaviors from a diary with readings from ultraviolet (UV) monitors worn on different body sites. The U's' monitors are stickers with panels that turn increasingly darker shades of blue in the presence of increasing amounts of UV light. Three schools participated (N = 527). Statistically significant associations were found between self-reported behaviors & the UV monitor measurements, with Kendall's tau b's ranging from 0.400 to 0.823. Multiple regression was performed & indicator variables created separately for arm (R = .12) & leg (R = .49) coverage by protective clothing. The effect of time spent outdoors on the UV monitor measure was attenuated when the students reported having the corresponding body site covered with clothing. Self-reported shade was not a significant predictor of UV monitor change. Overall, the results provide evidence of validity of students' self-reports of time outdoors & protective clothing use. Tables, References. [Reprinted by permission of Sage Publications Inc., copyright 2006, Society for Public Health Education.] JF - Health Education & Behavior AU - Yaroch, Amy L AU - Reynolds, Kim D AU - Buller, David B AU - Maloy, Julie A AU - Geno, Cristy R AD - Division Cancer Control & Population Sciences, National Cancer Instit, Bethesda, MD yarocha@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 340 EP - 351 PB - Sage Publications, Thousand Oaks CA VL - 33 IS - 3 SN - 1090-1981, 1090-1981 KW - validity KW - sun safety KW - measurement KW - Selfreport measures KW - Safety behaviour KW - Sunlight KW - Students KW - Middle schools KW - Validity studies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57071386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Validity+of+a+Sun+Safety+Diary+Using+UV+Monitors+in+Middle+School+Children&rft.au=Yaroch%2C+Amy+L%3BReynolds%2C+Kim+D%3BBuller%2C+David+B%3BMaloy%2C+Julie+A%3BGeno%2C+Cristy+R&rft.aulast=Yaroch&rft.aufirst=Amy&rft.date=2006-06-01&rft.volume=33&rft.issue=3&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198105285329 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Validity studies; Selfreport measures; Middle schools; Students; Sunlight; Safety behaviour DO - http://dx.doi.org/10.1177/1090198105285329 ER - TY - JOUR T1 - A New Ethnic for Health Promotion: Reflections on a Philosophy of Health Education for the 21st Century AN - 57068335; 200617515 AB - This article describes two models for thinking about the purposes of health education-a medical model & an education model-& traces how concerns about the validity of research have driven preference for the medical model. In the medical model, the purpose of health education is to develop effective interventions that will prevent people from adopting unhealthy behaviors. Here, health educators are expected to replicate the methods identified by researchers to effect targeted changes in health behavior. The article then describes an alternative way of thinking about the purposes of health education. In pursuing a philosophy of education, the purpose of research & practice would be to clarify basic social values & to strengthen one's faculty for making value judgments. Practitioners here use research results as a stimulus for dialogue about the role of good health habits in living the kind of life that community members find most valuable. References. [Reprinted by permission of Sage Publications Inc., copyright 2006, Society for Public Health Education.] JF - Health Education & Behavior AU - Buchanan, David R AD - Division Cancer Prevention, National Cancer Instit, Bethesda, MD buchanad@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 290 EP - 304 PB - Sage Publications, Thousand Oaks CA VL - 33 IS - 3 SN - 1090-1981, 1090-1981 KW - ethics KW - health education KW - health promotion KW - philosophy KW - research KW - Health education KW - Medical ethics KW - 21st century KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57068335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=A+New+Ethnic+for+Health+Promotion%3A+Reflections+on+a+Philosophy+of+Health+Education+for+the+21st+Century&rft.au=Buchanan%2C+David+R&rft.aulast=Buchanan&rft.aufirst=David&rft.date=2006-06-01&rft.volume=33&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198105276221 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Health promotion; Health education; 21st century; Medical ethics DO - http://dx.doi.org/10.1177/1090198105276221 ER - TY - JOUR T1 - Modeling the probability of arsenic in groundwater in New England as a tool for exposure assessment AN - 51259235; 2008-061871 JF - Environmental Science & Technology, ES & T AU - Ayotte, Joseph D AU - Nolan, Bernard T AU - Nuckols, John R AU - Cantor, Kenneth P AU - Robinson, Gilpin R, Jr AU - Baris, Dalsu AU - Hayes, Laura AU - Karagas, Margaret AU - Bress, William AU - Silverman, Debra T AU - Lubin, Jay H Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 3578 EP - 3585 PB - American Chemical Society, Washington, DC VL - 40 IS - 11 SN - 0013-936X, 0013-936X KW - United States KW - pollutants KW - statistical analysis KW - arsenic KW - prediction KW - pollution KW - environmental analysis KW - drinking water KW - Connecticut KW - ground water KW - aquifers KW - New Hampshire KW - models KW - metals KW - New England KW - risk assessment KW - probability KW - pesticides KW - Maine KW - water wells KW - water pollution KW - regression analysis KW - public health KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51259235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Modeling+the+probability+of+arsenic+in+groundwater+in+New+England+as+a+tool+for+exposure+assessment&rft.au=Ayotte%2C+Joseph+D%3BNolan%2C+Bernard+T%3BNuckols%2C+John+R%3BCantor%2C+Kenneth+P%3BRobinson%2C+Gilpin+R%2C+Jr%3BBaris%2C+Dalsu%3BHayes%2C+Laura%3BKaragas%2C+Margaret%3BBress%2C+William%3BSilverman%2C+Debra+T%3BLubin%2C+Jay+H&rft.aulast=Ayotte&rft.aufirst=Joseph&rft.date=2006-06-01&rft.volume=40&rft.issue=11&rft.spage=3578&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes051972f L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 56 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables, sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - aquifers; arsenic; Connecticut; drinking water; environmental analysis; ground water; Maine; metals; models; New England; New Hampshire; pesticides; pollutants; pollution; prediction; probability; public health; regression analysis; risk assessment; statistical analysis; United States; water pollution; water wells DO - http://dx.doi.org/10.1021/es051972f ER - TY - CPAPER T1 - Interferon-Gamma Influences Manifestations of Autoimmune Disease by Regulating Chemokines. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40123229; 4262026 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Su, Shao-Bo AU - Grajewski, Rafael AU - Agarwal, Rajeev AU - Silver, Phyllis AU - Tang, Jun AU - Chan, Chi-Chao AU - Caspi, Rachel Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - ^g-Interferon KW - Autoimmune diseases KW - Chemokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Interferon-Gamma+Influences+Manifestations+of+Autoimmune+Disease+by+Regulating+Chemokines.&rft.au=Su%2C+Shao-Bo%3BGrajewski%2C+Rafael%3BAgarwal%2C+Rajeev%3BSilver%2C+Phyllis%3BTang%2C+Jun%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel&rft.aulast=Su&rft.aufirst=Shao-Bo&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wnt5a Regulates Melanoma Antigen Recognized by T-Cells-1 (Mart-1),a Predominant Antigen in Melanoma Cells. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40117866; 4261929 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Dissanayake, Samudra AU - Rosenthal, Devin AU - Hewitt, Kyle AU - Yang, Sherry AU - Wade, Michael AU - Taub, Dennis AU - Nickoloff, Brian AU - Trent, Jeffrey AU - Bittner, Michael AU - Riker, Adam AU - Weeraratna, Ashani Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Melanoma KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40117866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Wnt5a+Regulates+Melanoma+Antigen+Recognized+by+T-Cells-1+%28Mart-1%29%2Ca+Predominant+Antigen+in+Melanoma+Cells.&rft.au=Dissanayake%2C+Samudra%3BRosenthal%2C+Devin%3BHewitt%2C+Kyle%3BYang%2C+Sherry%3BWade%2C+Michael%3BTaub%2C+Dennis%3BNickoloff%2C+Brian%3BTrent%2C+Jeffrey%3BBittner%2C+Michael%3BRiker%2C+Adam%3BWeeraratna%2C+Ashani&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Eradication of Tumor Colonization and Invasion by a B-Cell Specific Immunotoxin in a Murine Model for Human Primary Intraocular Lymphoma (PIOL). T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40111857; 4262239 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Li, Zhuqing AU - Sankaranarayana, Mahesh AU - Liu, Baoying AU - Chan, Chi-Chao AU - Shen, DeFeng AU - Pastan, Ira AU - Nussenblatt, Robert Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Lymphoma KW - Immunotoxins KW - Lymphocytes B KW - Animal models KW - Colonization KW - Tumors KW - Introduced species UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40111857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Eradication+of+Tumor+Colonization+and+Invasion+by+a+B-Cell+Specific+Immunotoxin+in+a+Murine+Model+for+Human+Primary+Intraocular+Lymphoma+%28PIOL%29.&rft.au=Li%2C+Zhuqing%3BSankaranarayana%2C+Mahesh%3BLiu%2C+Baoying%3BChan%2C+Chi-Chao%3BShen%2C+DeFeng%3BPastan%2C+Ira%3BNussenblatt%2C+Robert&rft.aulast=Li&rft.aufirst=Zhuqing&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Cell Injection as an Immuno-Regulatory Cell-Based Therapy in Scw-Induced Arthritis Model. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40086295; 4261866 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Perruche, Sylvain AU - Chen, Wanjun Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Apoptosis KW - Arthritis KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40086295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Apoptotic+Cell+Injection+as+an+Immuno-Regulatory+Cell-Based+Therapy+in+Scw-Induced+Arthritis+Model.&rft.au=Perruche%2C+Sylvain%3BChen%2C+Wanjun&rft.aulast=Perruche&rft.aufirst=Sylvain&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recombinant VK3-20 Protein as "Universal" Idiotypic Vaccine for HCV-Associated Lymphoproliferations. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40085346; 4261926 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Dolcetti, Riccardo AU - Martorelli, Debora AU - Gasparotto, Daniela AU - Caggiari, Laura AU - De Re, Valli AU - Mortarini, Roberta AU - Anichini, Andrea AU - Guidoboni, Massimo Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Vaccines KW - Disease control KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40085346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Recombinant+VK3-20+Protein+as+%22Universal%22+Idiotypic+Vaccine+for+HCV-Associated+Lymphoproliferations.&rft.au=Dolcetti%2C+Riccardo%3BMartorelli%2C+Debora%3BGasparotto%2C+Daniela%3BCaggiari%2C+Laura%3BDe+Re%2C+Valli%3BMortarini%2C+Roberta%3BAnichini%2C+Andrea%3BGuidoboni%2C+Massimo&rft.aulast=Dolcetti&rft.aufirst=Riccardo&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - V61q Mutation Supports Partial IFN-Gamma Receptor 1 Function. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40071179; 4262060 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Uzel, Gulbu AU - Patel, Smita AU - Routes, John AU - Holland, Steven Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Mutation KW - Receptor mechanisms KW - ^g-Interferon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40071179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=V61q+Mutation+Supports+Partial+IFN-Gamma+Receptor+1+Function.&rft.au=Uzel%2C+Gulbu%3BPatel%2C+Smita%3BRoutes%2C+John%3BHolland%2C+Steven&rft.aulast=Uzel&rft.aufirst=Gulbu&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased IL-13 Production by Lamina Propria Mononuclear Cells (LPMCS) Accompanies Ulcerative Colitis (UC) Remission and Clinical Response Induced by Interferon-@@u2@ Treatment T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40069905; 4261775 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Mannon, Peter AU - Fuss, Ivan AU - Groden, Catherine AU - Friend, Julia AU - Yang, Zhiqiong AU - Yi, Chuli AU - Dickensheets, Harold AU - Hornung, Ronald AU - Donnelly, Raymond AU - Strober, Warren Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Ulcerative colitis KW - Remission KW - Leukocytes (mononuclear) KW - Lamina propria KW - Interleukin 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40069905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Decreased+IL-13+Production+by+Lamina+Propria+Mononuclear+Cells+%28LPMCS%29+Accompanies+Ulcerative+Colitis+%28UC%29+Remission+and+Clinical+Response+Induced+by+Interferon-%40%40u2%40+Treatment&rft.au=Mannon%2C+Peter%3BFuss%2C+Ivan%3BGroden%2C+Catherine%3BFriend%2C+Julia%3BYang%2C+Zhiqiong%3BYi%2C+Chuli%3BDickensheets%2C+Harold%3BHornung%2C+Ronald%3BDonnelly%2C+Raymond%3BStrober%2C+Warren&rft.aulast=Mannon&rft.aufirst=Peter&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abrogation of Anti-Retinal Autoimmunity in IL-10 Transgenic Mice Due to Inhibition of Priming and Effector Function of Auto-Reactive T-Cells T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40032146; 4261795 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Agarwal, Rajeev AU - Viley, Angelia AU - Silver, Phyllis AU - Grajewski, Rafael AU - Kronenberg, Mitchell AU - Murray, Peter AU - Rutschman, Robert AU - Chan, Chi-Chao AU - Caspi, Rachel Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Mice KW - Interleukin 10 KW - Lymphocytes T KW - Autoimmunity KW - Transgenic mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40032146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Abrogation+of+Anti-Retinal+Autoimmunity+in+IL-10+Transgenic+Mice+Due+to+Inhibition+of+Priming+and+Effector+Function+of+Auto-Reactive+T-Cells&rft.au=Agarwal%2C+Rajeev%3BViley%2C+Angelia%3BSilver%2C+Phyllis%3BGrajewski%2C+Rafael%3BKronenberg%2C+Mitchell%3BMurray%2C+Peter%3BRutschman%2C+Robert%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel&rft.aulast=Agarwal&rft.aufirst=Rajeev&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Range of Potential Targets in Antigen-Specific Therapy are Expanded with Degenerate Autoantigen Recognition by T-Cells T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40023225; 4261972 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Quandt, Jacqueline AU - Huh, Jaebong AU - Pinilla, Clemencia AU - Ito, Kouichi AU - Martin, Roland Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Lymphocytes T KW - Autoantigens KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40023225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=The+Range+of+Potential+Targets+in+Antigen-Specific+Therapy+are+Expanded+with+Degenerate+Autoantigen+Recognition+by+T-Cells&rft.au=Quandt%2C+Jacqueline%3BHuh%2C+Jaebong%3BPinilla%2C+Clemencia%3BIto%2C+Kouichi%3BMartin%2C+Roland&rft.aulast=Quandt&rft.aufirst=Jacqueline&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunodominance of HLA B57-Restricted CD8+ T-Cell Responses in CMV/HIV Co-Infected B*57+ Long-Term Nonprogressors is Unique to HIV. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 40017861; 4262185 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Osborne, Christine AU - Jagannathan, Prasanna AU - Royce, Cassandra AU - Tilton, John AU - Connors, Mark AU - Migueles, Stephen Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Histocompatibility antigen HLA KW - Immunodominance KW - CD8 antigen KW - Lymphocytes T KW - Human immunodeficiency virus KW - Cytomegalovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40017861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Immunodominance+of+HLA+B57-Restricted+CD8%2B+T-Cell+Responses+in+CMV%2FHIV+Co-Infected+B*57%2B+Long-Term+Nonprogressors+is+Unique+to+HIV.&rft.au=Osborne%2C+Christine%3BJagannathan%2C+Prasanna%3BRoyce%2C+Cassandra%3BTilton%2C+John%3BConnors%2C+Mark%3BMigueles%2C+Stephen&rft.aulast=Osborne&rft.aufirst=Christine&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serotonin Synthesis, Storage and Transport in Human Mast Cells. T2 - 2006 Federation of Clinical Immunology Societies Annual Meeting AN - 39991984; 4261825 JF - 2006 Federation of Clinical Immunology Societies Annual Meeting AU - Kushnir-Sukhov, Nataliya AU - Brown, Jared AU - Wu, Yalin AU - Kirshenbaum, Arnold AU - Metcalfe, Dean Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 KW - Storage KW - Mast cells KW - Serotonin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.atitle=Serotonin+Synthesis%2C+Storage+and+Transport+in+Human+Mast+Cells.&rft.au=Kushnir-Sukhov%2C+Nataliya%3BBrown%2C+Jared%3BWu%2C+Yalin%3BKirshenbaum%2C+Arnold%3BMetcalfe%2C+Dean&rft.aulast=Kushnir-Sukhov&rft.aufirst=Nataliya&rft.date=2006-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Federation+of+Clinical+Immunology+Societies+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am06/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Specifying and implementing nonparametric and semiparametric survival estimators in two-stage (nested) cohort studies with missing case data AN - 37752916; 3279564 JF - Journal of the American Statistical Association AU - Mark, Steven D AU - Katki, Hormuzd A AD - University of Colorado ; National Cancer Institute, Bethesda Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 460 EP - 471 VL - 101 IS - 474 SN - 0162-1459, 0162-1459 KW - Economics KW - Sociology KW - Statistics KW - Case studies KW - Quantitative analysis KW - Cohort analysis KW - Health KW - Statistical methods KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37752916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Specifying+and+implementing+nonparametric+and+semiparametric+survival+estimators+in+two-stage+%28nested%29+cohort+studies+with+missing+case+data&rft.au=Mark%2C+Steven+D%3BKatki%2C+Hormuzd+A&rft.aulast=Mark&rft.aufirst=Steven&rft.date=2006-06-01&rft.volume=101&rft.issue=474&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214505000000952 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2457 2459 5676 3279 971 3286; 2056 10902; 10530 3279 971 3286; 5772; 12228 10919; 12233; 93 116 30 DO - http://dx.doi.org/10.1198/016214505000000952 ER - TY - JOUR T1 - Consensus Recommendations for the Use of ^sup 18^F-FDG PET as an Indicator of Therapeutic Response in Patients in National Cancer Institute Trials AN - 219183649; 16741317 JF - The Journal of Nuclear Medicine AU - Shankar, Lalitha K AU - Hoffman, John M AU - Bacharach, Steve AU - Graham, Michael M AU - et al Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1059 EP - 66 CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 6 SN - 01615505 KW - Physics KW - Radiopharmaceuticals KW - Fluorodeoxyglucose F18 KW - United States KW - Radiopharmaceuticals -- diagnostic use KW - Positron-Emission Tomography -- methods KW - Humans KW - National Institutes of Health (U.S.) KW - Treatment Outcome KW - Prognosis KW - Neoplasms -- radionuclide imaging KW - Outcome Assessment (Health Care) -- methods KW - Outcome Assessment (Health Care) -- standards KW - Clinical Trials as Topic -- standards KW - Positron-Emission Tomography -- standards KW - Fluorodeoxyglucose F18 -- diagnostic use KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219183649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=Consensus+Recommendations+for+the+Use+of+%5Esup+18%5EF-FDG+PET+as+an+Indicator+of+Therapeutic+Response+in+Patients+in+National+Cancer+Institute+Trials&rft.au=Shankar%2C+Lalitha+K%3BHoffman%2C+John+M%3BBacharach%2C+Steve%3BGraham%2C+Michael+M%3Bet+al&rft.aulast=Shankar&rft.aufirst=Lalitha&rft.date=2006-06-01&rft.volume=47&rft.issue=6&rft.spage=1059&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Jun 2006 N1 - Last updated - 2012-02-18 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - Guidelines for data and safety monitoring for clinical trials not requiring traditional data monitoring committees AN - 21341787; 10893835 AB - This is a commissioned report by a writing committee formed by the Society for Clinical Trials. The committee was formed with the objectives of 1) reviewing data monitoring guidelines for confirmatory (phase III) trials published by the National Institutes of Health, US Food and Drug Administration, Veterans Administration, and the International Conference on Harmonisation and 2) proposing corresponding guidelines for exploratory clinical trials (ie, most phase I and phase II trials and others not requiring a fully independent data monitoring committee). These trials typically involve fewer subjects and are of shorter duration than phase III trials. Nevertheless there are safety concerns, especially because these are often the first human trials for a new intervention. Recommendations are given for appropriate elements of a data monitoring plan, decision criteria for institution of a data monitoring committee (DMC), and critical elements for a DMC to consider in exploratory trials. Review and approval of data monitoring plans are suggested to fall under Institutional Review Board purview. Forming a committee with all the characteristics of a traditional phase III trial monitoring committee may be warranted for a small fraction of exploratory trials. Such a panel could consist of both trial investigators and outside members. The paper concludes with examples of data and safety monitoring practice from the University of Wisconsin Comprehensive Cancer Center and the AIDS Clinical Trials Groups. JF - Clinical Trials AU - Dixon, Dennis O AU - Freedman, Ralph S AU - Herson, Jay AU - Hughes, Michael AU - Kim, KyungMann AU - Silverman, Michael H AU - Tangen, Catherine M AD - National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA; NIAID/NIH, MSC 7609, Bethesda, MD 20892-7609, USA, dd23a@nih.giv Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 314 EP - 319 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 3 IS - 3 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts KW - Acquired immune deficiency syndrome KW - Conferences KW - committees KW - clinical trials KW - USA, Wisconsin KW - Cancer KW - guidelines KW - intervention KW - Reviews KW - Drugs KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21341787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Guidelines+for+data+and+safety+monitoring+for+clinical+trials+not+requiring+traditional+data+monitoring+committees&rft.au=Dixon%2C+Dennis+O%3BFreedman%2C+Ralph+S%3BHerson%2C+Jay%3BHughes%2C+Michael%3BKim%2C+KyungMann%3BSilverman%2C+Michael+H%3BTangen%2C+Catherine+M&rft.aulast=Dixon&rft.aufirst=Dennis&rft.date=2006-06-01&rft.volume=3&rft.issue=3&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1191%2F1740774506cn149oa LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Wisconsin; committees; clinical trials; guidelines; Reviews; Cancer; Conferences; Acquired immune deficiency syndrome; intervention; Drugs DO - http://dx.doi.org/10.1191/1740774506cn149oa ER - TY - JOUR T1 - A view of the digital landscape for neuroscience at NIH AN - 21210888; 11280696 AB - Abstract not available. JF - Neuroinformatics AU - Huerta, Michael F AU - Liu, Yuan AU - Glanzman, Dennis L AD - National Institute of Mental Health, NIH, Bethesda, MD, mhuert1@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 131 EP - 137 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 4 IS - 2 SN - 1539-2791, 1539-2791 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Nervous system KW - J1T KW - Landscape KW - Bioinformatics KW - J1L KW - W 30965:Miscellaneous, Reviews KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=A+view+of+the+digital+landscape+for+neuroscience+at+NIH&rft.au=Huerta%2C+Michael+F%3BLiu%2C+Yuan%3BGlanzman%2C+Dennis+L&rft.aulast=Huerta&rft.aufirst=Michael&rft.date=2006-06-01&rft.volume=4&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1385%2FNI%3A4%3A2%3A131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - J1T; J1L; Nervous system; Bioinformatics; Landscape DO - http://dx.doi.org/10.1385/NI:4:2:131 ER - TY - JOUR T1 - The Likelihood as Statistical Evidence in Multiple Comparisons in Clinical Trials: No Free Lunch AN - 21069997; 11132847 AB - The likelihood ratio summarizes the strength of statistical evidence for one simple pre-determined hypothesis versus another. However, it does not directly address the multiple comparisons problem. In this paper we discuss some concerns related to the application of likelihood ratio methods to several multiple comparisons issues in clinical trials, in particular, subgroup analysis, multiple variables, interim monitoring, and data driven choice of hypotheses. JF - Biometrical Journal AU - Korn, Edward L AU - Freidlin, Boris AD - Biometric Research Branch, EPN-8129, National Cancer Institute, Bethesda, MD 20892-7434, USA, korne@ctep.nci.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 346 EP - 355 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 3 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21069997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=The+Likelihood+as+Statistical+Evidence+in+Multiple+Comparisons+in+Clinical+Trials%3A+No+Free+Lunch&rft.au=Korn%2C+Edward+L%3BFreidlin%2C+Boris&rft.aulast=Korn&rft.aufirst=Edward&rft.date=2006-06-01&rft.volume=48&rft.issue=3&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200510216 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistics; Clinical trials; Data processing DO - http://dx.doi.org/10.1002/bimj.200510216 ER - TY - JOUR T1 - Delineating the Requirement for the Borrelia burgdorferi Virulence Factor OspC in the Mammalian Host AN - 20991467; 6947002 AB - We previously demonstrated that outer surface protein C (OspC) of Borrelia burgdorferi is essential for establishing mammalian infection. However, the role of OspC in mammalian infection is unknown. Here, we report experiments designed to distinguish between two models of OspC function in the mammalian host: (i) OspC fulfills an essential physiological role for growth and host adaptation or (ii) OspC provides a protective role for evasion of components of the innate immune response. We found that a B. burgdorferi ospC mutant, previously demonstrated to be noninfectious in both immunocompetent and SCID mice, could survive in the relatively immune-privileged environment of dialysis membrane chambers implanted within the peritoneum of a rat. The ospC mutant also adapts to the mammalian environment, as determined by the protein profiles of the chamber-cultivated spirochetes. Therefore, OspC does not appear to provide a physiological function for the survival of B. burgdorferi within the mammalian host. The second model, evasion of the innate immune system, was tested by assessing the infectivity of the ospC mutant in mice deficient for myeloid differentiation protein 88 (MyD88). Recent studies have shown that B. burgdorferi is prevented from reaching high cell numbers in the mammalian host by MyD88-dependent signaling pathways. The ospC mutant was incapable of infecting MyD88-deficient mice, suggesting that the role of OspC cannot be related solely to evasion of MyD88-mediated innate immunity. These results reiterate the importance of OspC in mammalian infection and eliminate simple models of function for this enigmatic protein. JF - Infection and Immunity AU - Stewart, Philip E AU - Wang, Xiaohui AU - Bueschel, Dawn M AU - Clifton, Dawn R AU - Grimm, Dorothee AU - Tilly, Kit AU - Carroll, James A AU - Weis, Janis J AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th St., Hamilton, Montana 59840. Department of Pathology, University of Utah, Salt Lake City, Utah 84132. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3547 EP - 3553 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Dialysis KW - Adaptations KW - virulence factors KW - Cell number KW - Borrelia burgdorferi KW - MyD88 protein KW - Peritoneum KW - Animal models KW - Immunity KW - Infection KW - Immune privilege KW - Spirochetes KW - Differentiation KW - Infectivity KW - outer surface protein C KW - Immune response KW - Signal transduction KW - G 07320:Bacterial genetics KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20991467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Delineating+the+Requirement+for+the+Borrelia+burgdorferi+Virulence+Factor+OspC+in+the+Mammalian+Host&rft.au=Stewart%2C+Philip+E%3BWang%2C+Xiaohui%3BBueschel%2C+Dawn+M%3BClifton%2C+Dawn+R%3BGrimm%2C+Dorothee%3BTilly%2C+Kit%3BCarroll%2C+James+A%3BWeis%2C+Janis+J%3BRosa%2C+Patricia+A&rft.aulast=Stewart&rft.aufirst=Philip&rft.date=2006-06-01&rft.volume=74&rft.issue=6&rft.spage=3547&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dialysis; Adaptations; Cell number; virulence factors; MyD88 protein; Peritoneum; Animal models; Immunity; Infection; Immune privilege; Differentiation; Spirochetes; Infectivity; outer surface protein C; Immune response; Signal transduction; Borrelia burgdorferi ER - TY - JOUR T1 - Borrelia burgdorferi OspC Protein Required Exclusively in a Crucial Early Stage of Mammalian Infection AN - 20987863; 6947003 AB - This study demonstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals. OspC is a major surface protein produced by B. burgdorferi when infected ticks feed but whose synthesis decreases after transmission to a mammalian host. We have previously shown that spirochetes lacking OspC are competent to replicate in and migrate to the salivary glands of the tick vector but do not infect mice. Here we assessed the timing of the requirement for OspC by using an ospC mutant complemented with an unstable copy of the ospC gene and show that B. burgdorferi's requirement for OspC is specific to the mammal and limited to a critical early stage of mammalian infection. By using this unique system, we found that most bacterial reisolates from mice persistently infected with the initially complemented ospC mutant strain no longer carried the wild-type copy of ospC. Such spirochetes were acquired by feeding ticks and migrated to the tick salivary glands during subsequent feeding. Despite normal behavior in ticks, these ospC mutant spirochetes did not infect naive mice. ospC mutant spirochetes from persistently infected mice also failed to infect naive mice by tissue transplantation. We conclude that OspC is indispensable for establishing infection by B. burgdorferi in mammals but is not required at any other point of the mouse-tick infection cycle. JF - Infection and Immunity AU - Tilly, Kit AU - Krum, Jonathan G AU - Bestor, Aaron AU - Jewett, Mollie W AU - Grimm, Dorothee AU - Bueschel, Dawn AU - Byram, Rebecca AU - Dorward, David AU - VanRaden, Mark J AU - Stewart, Philip AU - Rosa, Patricia AD - Laboratory of Zoonotic Pathogens, and Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3554 EP - 3564 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 6 SN - 0019-9567, 0019-9567 KW - Ticks KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Feeding KW - Borrelia burgdorferi KW - Ixodidae KW - Vectors KW - Salivary gland KW - Infection KW - Migration KW - Disease transmission KW - Virulence KW - Spirochetes KW - Complementation KW - ospC gene KW - Feeding behavior KW - Lyme disease KW - G 07320:Bacterial genetics KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Borrelia+burgdorferi+OspC+Protein+Required+Exclusively+in+a+Crucial+Early+Stage+of+Mammalian+Infection&rft.au=Tilly%2C+Kit%3BKrum%2C+Jonathan+G%3BBestor%2C+Aaron%3BJewett%2C+Mollie+W%3BGrimm%2C+Dorothee%3BBueschel%2C+Dawn%3BByram%2C+Rebecca%3BDorward%2C+David%3BVanRaden%2C+Mark+J%3BStewart%2C+Philip%3BRosa%2C+Patricia&rft.aulast=Tilly&rft.aufirst=Kit&rft.date=2006-06-01&rft.volume=74&rft.issue=6&rft.spage=3554&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Feeding; Spirochetes; Complementation; Vectors; ospC gene; Infection; Feeding behavior; Salivary gland; Migration; Disease transmission; Lyme disease; Borrelia burgdorferi; Ixodidae ER - TY - JOUR T1 - Understanding and Managing Methotrexate Nephrotoxicity AN - 20980846; 6999441 AB - Methotrexate (MTX) is one of the most widely used anti-cancer agents, and administration of high-dose methotrexate (HDMTX) followed by leucovorin (LV) rescue is an important component in the treatment of a variety of childhood and adult cancers. HDMTX can be safely administered to patients with normal renal function by the use of alkalinization, hydration, and pharmacokinetically guided LV rescue. Despite these measures, HDMTX-induced renal dysfunction continues to occur in approximately 1.8% of patients with osteosarcoma treated on clinical trials. Prompt recognition and treatment of MTX-induced renal dysfunction are essential to prevent potentially life-threatening MTX-associated toxicities, especially myelosuppression, mucositis, and dermatitis. In addition to conventional treatment approaches, dialysis-based methods have been used to remove MTX with limited effectiveness. More recently carboxypeptidase-G sub(2) (CPDG sub(2)), a recombinant bacterial enzyme that rapidly hydrolyzes MTX to inactive metabolites, has become available for the treatment of HDMTX-induced renal dysfunction. CPDG sub(2) administration has been well tolerated and resulted in consistent and rapid reductions in plasma MTX concentrations by a median of 98.7% (range, 84%-99.5%). The early administration of CPDG sub(2) in addition to LV may be beneficial for patients with MTX-induced renal dysfunction and significantly elevated plasma MTX concentrations. JF - Oncologist AU - Widemann, Brigitte C AU - Adamson, Peter C AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. Division of Clinical Pharmacology & Therapeutics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 694 EP - 703 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 11 IS - 6 SN - 1083-7159, 1083-7159 KW - Microbiology Abstracts B: Bacteriology KW - Hydration KW - Mucositis KW - Enzymes KW - Osteosarcoma KW - Metabolites KW - Toxicity KW - Children KW - Clinical trials KW - Cancer KW - Renal function KW - Myelosuppression KW - Methotrexate KW - Dermatitis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20980846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=Understanding+and+Managing+Methotrexate+Nephrotoxicity&rft.au=Widemann%2C+Brigitte+C%3BAdamson%2C+Peter+C&rft.aulast=Widemann&rft.aufirst=Brigitte&rft.date=2006-06-01&rft.volume=11&rft.issue=6&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hydration; Mucositis; Osteosarcoma; Enzymes; Metabolites; Toxicity; Children; Clinical trials; Cancer; Renal function; Methotrexate; Myelosuppression; Dermatitis ER - TY - JOUR T1 - Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in Cancer AN - 20967165; 8515862 AB - Heat shock protein 90 (Hsp90) is a molecular chaperone whose association is required for stability and function of multiple mutated, chimeric, and over-expressed signaling proteins that promote cancer cell growth and/or survival. Hsp90 client proteins include telomerase, mutated p53, Bcr-Abl, Raf-1, Akt, HER2/Neu (ErbB2), mutated B-Raf, mutated EGF receptor, and HIF- 1 alpha . Hsp90 inhibitors, by interacting specifically with a single molecular target, cause inactivation, destabilization and eventual degradation of Hsp90 client proteins, and they have shown promising anti-tumor activity in various preclinical tumor models. One Hsp90 inhibitor, 17-AAG, is currently in Phas IIE clinical trial and other inhibitors will shortly be entering the clinic. Hsp90 inhibitors are unique in that, although they are directed towards a specific molecular target, they simultaneously inhibit multiple signaling pathways on which cancer cells depend for growth and survival. Identification of benzoquinone ansamycins as the first Hsp90 inhibitors allowed investigators to determine the biologic effects, at first in vitro and then in vivo, of pharmacologic inhibition of Hsp90. These studies rapidly enhanced our understanding of Hsp90 function and led to the identification of radicicol as a structurally distinct Hsp90 inhibitor. Additional target-based screening uncovered novobiocin as a third structurally distinct small molecule with Hsp90 inhibitory properties. Use of novobiocin, in turn, led to identification of a previously uncharacterized C-terminal ATP binding site in the chaperone. Small molecule inhibitors of Hsp90 have been very useful in understanding Hsp90 biology and in validating this protein as a molecular target for anti-cancer drug development. JF - Current Topics in Medicinal Chemistry AU - Neckers, Len AD - Urologic Oncology Branch,National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 1- 5940, Bethesda, MD 20892-1107. Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1163 EP - 1171 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 6 IS - 11 SN - 1568-0266, 1568-0266 KW - Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Molecular modelling KW - Heat shock proteins KW - ErbB-2 protein KW - Telomerase KW - natural products KW - Clinical trials KW - BCR protein KW - AKT protein KW - Abl protein KW - Novobiocin KW - ATP KW - Drug development KW - Tumors KW - Antitumor agents KW - Cancer KW - p53 protein KW - Hsp90 protein KW - Benzoquinone KW - Ansamycins KW - Reviews KW - Chaperones KW - Fusion protein KW - Epidermal growth factor KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=Using+Natural+Product+Inhibitors+to+Validate+Hsp90+as+a+Molecular+Target+in+Cancer&rft.au=Neckers%2C+Len&rft.aulast=Neckers&rft.aufirst=Len&rft.date=2006-06-01&rft.volume=6&rft.issue=11&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802606777811979 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hsp90 protein; ErbB-2 protein; Cancer; Cell survival; Signal transduction; Novobiocin; Chaperones; Telomerase; Clinical trials; Abl protein; natural products; AKT protein; Tumors; Reviews; p53 protein; Ansamycins; Benzoquinone; Heat shock proteins; BCR protein; Drug development; Epidermal growth factor; ATP; Antitumor agents; Fusion protein; Molecular modelling DO - http://dx.doi.org/10.2174/156802606777811979 ER - TY - JOUR T1 - Use of genomic signatures in therapeutics development in oncology and other diseases AN - 20633235; 7041537 AB - Pharmacogenomics is the science of determining how the benefits and adverse effects of a drug vary among a target population of patients based on genomic features of the patient's germ line and diseased tissue. By identifying those patients who are most likely to respond while eliminating serious adverse effects, the therapeutic index of a drug can be substantially increased. This may facilitate demonstrating the effectiveness of the drug and may avoid subsequent problems due to serious adverse events. Our objective here is to provide clinical trial designs and analysis strategies for the utilization of genomic signatures as classifiers for patient stratification or patient selection in therapeutics development. We review methods for the development of genomic signature classifiers of treatment outcome in high-dimensional settings, where the number of variables available for prediction far exceeds the number of cases. The split-sample and cross-validation methods for obtaining estimates of prediction accuracy in developmental studies are described. We present clinical trial designs for utilizing genomic signature classifiers in therapeutics development. The purpose of the classifier is to facilitate the identification of groups of patients with a high probability of benefiting from it and avoiding serious adverse events. We distinguish exploratory analysis during the development of the genomic classifier from prospective planning and rigorous testing of therapeutic hypotheses in studies that utilize the genomic classifier in therapeutics development. We discuss a variety of clinical trial designs including those utilizing specimen collection and assay prospectively for newly accrued patients and those involving a prospectively planned analysis of archived specimens from a previously conducted clinical trial. Our discussion of the development and use of classifiers of efficacy is mostly focused on applications in oncology using classifiers based on biomarkers measured in tumors. Some of the same considerations apply, however, to development of efficacy and safety classifiers in nononcologic diseases based on single-nucleotide germline polymorphisms. JF - Pharmacogenomics Journal AU - Simon, R AU - Wang, S-J AD - Biometric Research Branch, Division of Cancer Treatment & Diagnosis, National Cancer Institute, NIH, MSC 7434, 9000 Rockville Pike, Bethesda, MD 20892-7434, USA, rsimon@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 166 EP - 173 VL - 6 IS - 3 SN - 1470-269X, 1470-269X KW - Biotechnology Research Abstracts (through 1992); Genetics Abstracts KW - pharmacogenomics KW - Oncology KW - Drug development KW - Tumors KW - biomarkers KW - Clinical trials KW - genomics KW - Drugs KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20633235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics+Journal&rft.atitle=Use+of+genomic+signatures+in+therapeutics+development+in+oncology+and+other+diseases&rft.au=Simon%2C+R%3BWang%2C+S-J&rft.aulast=Simon&rft.aufirst=R&rft.date=2006-06-01&rft.volume=6&rft.issue=3&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics+Journal&rft.issn=1470269X&rft_id=info:doi/10.1038%2Fsj.tpj.6500349 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genomics; Drug development; Clinical trials; Drugs; Side effects; Oncology; biomarkers; pharmacogenomics; Tumors DO - http://dx.doi.org/10.1038/sj.tpj.6500349 ER - TY - JOUR T1 - Advances in Homology Protein Structure Modeling AN - 20526506; 7658971 AB - Homology modeling plays a central role in determining protein structure in the structural genomics project. The importance of homology modeling has been steadily increasing because of the large gap that exists between the overwhelming number of available protein sequences and experimentally solved protein structures, and also, more importantly, because of the increasing reliability and accuracy of the method. In fact, a protein sequence with over 30% identity to a known structure can often be predicted with an accuracy equivalent to a low-resolution X-ray structure. The recent advances in homology modeling, especially in detecting distant homologues, aligning sequences with template structures, modeling of loops and side chains, as well as detecting errors in a model, have contributed to reliable prediction of protein structure, which was not possible even several years ago. The ongoing efforts in solving protein structures, which can be time-consuming and often difficult, will continue to spur the development of a host of new computational methods that can fill in the gap and further contribute to understanding the relationship between protein structure and function. JF - Current Protein & Peptide Science AU - Xiang, Zhexin AD - Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Building 12A Room 2051, 12 South Drive, Bethesda, Maryland 20892- 5624, USA. Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 217 EP - 227 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 3 SN - 1389-2037, 1389-2037 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - N3 11002:Computational & theoretical neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20526506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Protein+%26+Peptide+Science&rft.atitle=Advances+in+Homology+Protein+Structure+Modeling&rft.au=Xiang%2C+Zhexin&rft.aulast=Xiang&rft.aufirst=Zhexin&rft.date=2006-06-01&rft.volume=7&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Current+Protein+%26+Peptide+Science&rft.issn=13892037&rft_id=info:doi/10.2174%2F138920306777452312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.2174/138920306777452312 ER - TY - JOUR T1 - Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe AN - 20398406; 7760045 AB - Background: A number of fluorescent caspase substrates and FRET-based indicators have been developed to study the in vivo activation of caspases, a conserved family of proteases critical in inflammatory, and apoptosis signaling pathways. To date, all substrates have measured only one caspase activity. Here, we describe a FRET-based probe for simultaneously measuring two distinct caspase activities in living cells. Methods: This probe consists of a CFP-YFP-mRFP fusion protein containing a caspase-3-cleavage motif, DEVD, between CFP and YFP, and a caspase-6-cleavage site, VEID, between YFP and mRFP. DEVDase and VEIDase activities could be assessed simultaneously by monitoring diminished FRET mediated by cleavage of either or both of these protease cleavage sites using flow cytometry. Results: DEVDase and VEIDase activities were completely inhibited by the pan-caspase inhibitor z-VAD-fmk and enhanced by DNA-damaging drugs or by anti-Fas stimulation. DEVD and VEID cleavage specificities were validated by using caspase-3-deficient MCF7-Fas cells and a caspase-6-specific inhibitor. Kinetic analysis with the FRET probe revealed that caspase-3 activation consistently preceded caspase-6 by 30 min following induction of apoptosis. Conclusions: We have developed a novel FRET-based probe for simultaneous detection of two caspase activities in living cells using flow cytometry. Simultaneous detection of two caspase activities using this probe has clearly provided information of the ordering of caspase-3 and -6 in the apoptotic pathway. JF - Cytometry Part A AU - Wu, Xiaoli AU - Simone, James AU - Hewgill, Derek AU - Siegel, Richard AU - Lipsky, Peter E AU - He, Liusheng AD - Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, liusheng.he@stjude.org Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 477 EP - 486 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 69A IS - 6 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Caspase-6 KW - fluorescence resonance energy transfer KW - Inflammation KW - Flow cytometry KW - Kinetics KW - Caspase-3 KW - Fluorescent indicators KW - Proteinase KW - Fusion protein KW - Drugs KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20398406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Measurement+of+two+caspase+activities+simultaneously+in+living+cells+by+a+novel+dual+FRET+fluorescent+indicator+probe&rft.au=Wu%2C+Xiaoli%3BSimone%2C+James%3BHewgill%2C+Derek%3BSiegel%2C+Richard%3BLipsky%2C+Peter+E%3BHe%2C+Liusheng&rft.aulast=Wu&rft.aufirst=Xiaoli&rft.date=2006-06-01&rft.volume=69A&rft.issue=6&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20300 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - fluorescence resonance energy transfer; Apoptosis; Fluorescent indicators; Proteinase; Flow cytometry; Caspase-3; Inflammation; Fusion protein; Signal transduction; Kinetics; Caspase-6; Drugs DO - http://dx.doi.org/10.1002/cyto.a.20300 ER - TY - JOUR T1 - Proximity to Crops and Residential Exposure to Agricultural Herbicides in Iowa AN - 20390089; 7018330 AB - Rural residents can be exposed to agricultural pesticides through the proximity of their homes to crop fields. Previously, we developed a method to create historical crop maps using a geographic information system. The aim of the present study was to determine whether crop maps are useful for predicting levels of crop herbicides in carpet dust samples from residences. From homes of participants in a case-control study of non-Hodgkin lymphoma in Iowa (1998-2000), we collected vacuum cleaner dust and measured 14 herbicides with high use on corn and soybeans in Iowa. Of 112 homes, 58% of residences had crops within 500 m of their home, an intermediate distance for primary drift from aerial and ground applications. Detection rates for herbicides ranged from 0% for metribuzin and cyanazine to 95% for 2,4-dichlorophenoxyacetic acid. Six herbicides used almost exclusively in agriculture were detected in 28% of homes. Detections and concentrations were highest in homes with an active farmer. Increasing acreage of corn and soybean fields within 750 m of homes was associated with significantly elevated odds of detecting agricultural herbicides compared with homes with no crops within 750 m (adjusted odds ratio per 10 acres = 1.06; 95% confidence interval, 1.02-1.11). Herbicide concentrations also increased significantly with increasing acreage within 750 m. We evaluated the distance of crop fields from the home at < 100, 101-250, 251-500, and 501-750 m. Including the crop buffer distance parameters in the model did not significantly improve the fit compared with a model with total acres within 750 m. Our results indicate that crop maps may be a useful method for estimating levels of herbicides in homes from nearby crop fields. JF - Environmental Health Perspectives AU - Ward, M H AU - Lubin, J AU - Gigllerano, J AU - Colt, J S AU - Wolter, C AU - Bekiroglu, N AU - Camann, D AU - Hartge, P AU - Nuckols, J R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., EPS 8104, Bethesda, MD 20892, USA, wardm@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 893 EP - 897 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Agriculture KW - Historical account KW - Remote sensing KW - agriculture KW - Environmental health KW - Herbicides KW - corn KW - Dust KW - Crops KW - USA, Iowa KW - Pesticides KW - crop fields KW - Residential areas KW - 2,4-Dichlorophenoxyacetic acid KW - Geographic information systems KW - lymphoma KW - soybeans KW - H 5000:Pesticides KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20390089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Proximity+to+Crops+and+Residential+Exposure+to+Agricultural+Herbicides+in+Iowa&rft.au=Ward%2C+M+H%3BLubin%2C+J%3BGigllerano%2C+J%3BColt%2C+J+S%3BWolter%2C+C%3BBekiroglu%2C+N%3BCamann%2C+D%3BHartge%2C+P%3BNuckols%2C+J+R&rft.aulast=Ward&rft.aufirst=M&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8770 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Agriculture; Historical account; agriculture; Remote sensing; Environmental health; Herbicides; Crops; Dust; corn; Pesticides; Residential areas; crop fields; 2,4-Dichlorophenoxyacetic acid; Geographic information systems; lymphoma; soybeans; USA, Iowa DO - http://dx.doi.org/10.1289/ehp.8770 ER - TY - JOUR T1 - Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System AN - 20247952; 6949284 AB - Drug delivery to the brain is highly restricted, since compounds must cross a series of structural and metabolic barriers to reach their final destination, often a cellular compartment such as neurons, microglia, or astrocytes. The primary barriers to the central nervous system are the blood-brain and blood-cerebrospinal fluid barriers. Through structural modifications, including the presence of tight junctions that greatly limit paracellular transport, the cells that make up these barriers restrict diffusion of many pharmaceutically active compounds. In addition, the cells that comprise the blood-brain and blood-cerebrospinal fluid barriers express multiple ATP-dependent, membrane-bound, efflux transporters, such as members of the multidrug resistance-associated protein (MRP) family, which contribute to lowered drug accumulation. A relatively new concept in brain drug distribution just beginning to be explored is the possibility that cellular components of the brain parenchyma could act as a "second" barrier to brain permeation of pharmacological agents via expression of many of the same transporters. Indeed, efflux transporters expressed in brain parenchyma may facilitate the overall export of xenobiotics from the central nervous system, essentially handing themoff to the barrier tissues. We propose that these primary and secondary barriers work in tandem to limit overall accumulation and distribution of xenobiotics in the central nervous system. The present review summarizes recent knowledge in this area and emphasizes the clinical significance of MRP transporter expression in a variety of neurological disorders. JF - Pharmacological Reviews AU - Dallas, Shannon AU - Miller, David S AU - Bendayan, Reina AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (S.D., D.S.M.) Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 140 EP - 161 PB - American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike Bethesda MD 20814-3995 USA, [mailto:info@aspet.org], [URL:http://www.aspet.org] VL - 58 IS - 2 SN - 0031-6997, 0031-6997 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Parenchyma KW - Drug delivery KW - Central nervous system KW - Neurological diseases KW - Tight junctions KW - Astrocytes KW - Brain KW - Xenobiotics KW - Microglia KW - Neurons KW - Reviews KW - MRP protein KW - Diffusion KW - N3 11094:Central nervous system KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+Reviews&rft.atitle=Multidrug+Resistance-Associated+Proteins%3A+Expression+and+Function+in+the+Central+Nervous+System&rft.au=Dallas%2C+Shannon%3BMiller%2C+David+S%3BBendayan%2C+Reina&rft.aulast=Dallas&rft.aufirst=Shannon&rft.date=2006-06-01&rft.volume=58&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Pharmacological+Reviews&rft.issn=00316997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Parenchyma; Central nervous system; Drug delivery; Neurological diseases; Astrocytes; Tight junctions; Brain; Xenobiotics; Microglia; Reviews; Neurons; MRP protein; Diffusion ER - TY - JOUR T1 - Rapid Succession within the Veillonella Population of a Developing Human Oral Biofilm In Situ AN - 20247081; 6947327 AB - Streptococci are the primary component of the multispecies oral biofilm known as supragingival dental plaque; they grow by fermentation of sugars to organic acids, e.g., lactic acid. Veillonellae, a ubiquitous component of early plaque, are unable to use sugars; they ferment organic acids, such as lactate, to a mixture of shorter-chain-length acids, CO sub(2), and hydrogen. Certain veillonellae bind to (coaggregate with) streptococci in vitro. We show that, between 4 and 8 hours into plaque development, the dominant strains of Veillonella change in their phenotypic characteristics (coaggregation and antibody reactivity) as well as in their genotypic characteristics (16S RNA gene sequences as well as strain level fingerprint patterns). This succession is coordinated with the development of mixed-species bacterial colonies. Changes in community structure can occur very rapidly in natural biofilm development, and we suggest that this process may influence evolution within this ecosystem. JF - Journal of Bacteriology AU - Palmer, Robert JJr AU - Diaz, Patricia I AU - Kolenbrander, Paul E AD - Oral Biofilm Communication Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg. 30, Room 310, Bethesda, Maryland 20892 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 4117 EP - 4124 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 11 SN - 0021-9193, 0021-9193 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Sugar KW - Fermentation KW - Development KW - Hydrogen KW - Dental plaque KW - Succession KW - Antibodies KW - organic acids KW - Colonies KW - RNA KW - Community structure KW - Acids KW - Veillonella KW - Lactic acid KW - Plaques KW - Biofilms KW - Carbon dioxide KW - Evolution KW - W 30950:Waste Treatment & Pollution Clean-up KW - G 07320:Bacterial genetics KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Rapid+Succession+within+the+Veillonella+Population+of+a+Developing+Human+Oral+Biofilm+In+Situ&rft.au=Palmer%2C+Robert+JJr%3BDiaz%2C+Patricia+I%3BKolenbrander%2C+Paul+E&rft.aulast=Palmer&rft.aufirst=Robert&rft.date=2006-06-01&rft.volume=188&rft.issue=11&rft.spage=4117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sugar; Fermentation; Hydrogen; Development; Succession; Dental plaque; Colonies; organic acids; Antibodies; RNA; Community structure; Acids; Lactic acid; Plaques; Biofilms; Carbon dioxide; Evolution; Veillonella ER - TY - JOUR T1 - The complexity of antisense transcription revealed by the study of developing male germ cells AN - 20246478; 6909633 AB - Computational analyses have identified the widespread occurrence of antisense transcripts in the human and the mouse genome. However, the structure and the origin of the majority of the antisense transcripts are unknown. The presence of antisense transcripts for 19 of 64 differentially expressed genes during mouse spermatogenesis was demonstrated with orientation-specific RT-PCR. These antisense transcripts were derived from a wide variety of origins, including processed sense transcripts, intronic and exonic sequences of a single gene or multiple genes, intergenic sequences, and pseudogenes. They underwent normal and alternative splicing, 5' capping, and 3' polyadenylation, similar to the sense transcripts. There were also antisense transcripts that were not capped and/or polyadenylated. The testicular levels of the sense transcripts were higher than those of the antisense transcripts in all cases, while the relative expression in nontesticular tissues was variable. Thus antisense transcripts have complex origins and structures and the sense and antisense transcripts can be regulated independently. JF - Genomics AU - Chan, W Y AU - Wu, S M AU - Ruszczyk, L AU - Law, E AU - Lee, T L AU - Baxendale, V AU - Lap-Yin Pang, A AU - Rennert, OM AD - National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 2A08, 49 Convent Drive, MSC 4429, Bethesda, MD 20892-4429, USA, chanwy@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 681 EP - 692 VL - 87 IS - 6 SN - 0888-7543, 0888-7543 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Testes KW - Pseudogenes KW - Antisense KW - Germ cells KW - Transcription KW - Polymerase chain reaction KW - Polyadenylation KW - Computer applications KW - Spermatogenesis KW - Sensory systems KW - Alternative splicing KW - N 14840:Antisense, Nucleotide Analogs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20246478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=The+complexity+of+antisense+transcription+revealed+by+the+study+of+developing+male+germ+cells&rft.au=Chan%2C+W+Y%3BWu%2C+S+M%3BRuszczyk%2C+L%3BLaw%2C+E%3BLee%2C+T+L%3BBaxendale%2C+V%3BLap-Yin+Pang%2C+A%3BRennert%2C+OM&rft.aulast=Chan&rft.aufirst=W&rft.date=2006-06-01&rft.volume=87&rft.issue=6&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2005.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Testes; Pseudogenes; Antisense; Germ cells; Polymerase chain reaction; Transcription; Polyadenylation; Computer applications; Sensory systems; Spermatogenesis; Alternative splicing DO - http://dx.doi.org/10.1016/j.ygeno.2005.12.006 ER - TY - JOUR T1 - Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt]endomorphin-1 AN - 20228750; 6986439 AB - [Dmt]Endomorphin-1 is a novel analogue of the potent mu -opioid agonist endomorphin-1. Given the physiological role of endomorphin-1 in vivo, this compound was investigated to determine if the antinociception occurred through systemic, supraspinal or in a combination of both neuronal pathways. This compound exhibited a potent dose-dependent effect intracerebroventricularly in both spinal and supraspinal regions, and was blocked by opioid antagonist naloxone, which verified the involvement of opioid receptors. Specific opioid antagonists characterized the apparent receptor type: beta -funaltrexamine ( mu sub(1)/ mu sub(2)-irreversible antagonist) equally inhibited spinal- and central- mediated antinociception; on the other hand, naloxonazine ( mu sub(1)-subtype) was ineffective in both neural pathways and naltrindole ( delta -selective antagonist) partially (26%), though not significantly, blocked only the spinal-mediated antinociception. Therefore, spinal antinociception was primarily triggered by mu sub(2)-subtypes without involvement of mu sub(1)-opioid receptors; however, although a slight enhancement of antinociception by delta -receptors cannot be completely ruled out since functional bioactivity indicated mixed mu -agonism/ delta -antagonism. In terms of the CNS action, [Dmt]endomorphin-1 appears to act through mu sub(2)-opioid receptor subtypes. JF - Pharmacology Biochemistry and Behavior AU - Jinsmaa, Yunden AU - Marczak, Ewa AU - Fujita, Yoshio AU - Shiotani, Kimitaka AU - Miyazaki, Anna AU - Li, Tingyou AU - Tsuda, Yuko AU - Ambo, Akihiro AU - Sasaki, Yusuke AU - Bryant, Sharon D AU - Okada, Yoshio AU - Lazarus, Lawrence H AD - Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, yunden@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 252 EP - 258 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 84 IS - 2 SN - 0091-3057, 0091-3057 KW - Animal Behavior Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Antinociception KW - Dimethyltyrosine KW - Endomorphin KW - Opioid receptor subtypes KW - Spinal KW - Supraspinal KW - Opioid receptors KW - Endomorphin-1 KW - Central nervous system KW - Naltrindole KW - Pain perception KW - Naloxone KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20228750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Potent+in+vivo+antinociception+and+opioid+receptor+preference+of+the+novel+analogue+%5BDmt%5Dendomorphin-1&rft.au=Jinsmaa%2C+Yunden%3BMarczak%2C+Ewa%3BFujita%2C+Yoshio%3BShiotani%2C+Kimitaka%3BMiyazaki%2C+Anna%3BLi%2C+Tingyou%3BTsuda%2C+Yuko%3BAmbo%2C+Akihiro%3BSasaki%2C+Yusuke%3BBryant%2C+Sharon+D%3BOkada%2C+Yoshio%3BLazarus%2C+Lawrence+H&rft.aulast=Jinsmaa&rft.aufirst=Yunden&rft.date=2006-06-01&rft.volume=84&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2006.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Central nervous system; Endomorphin-1; Naltrindole; Pain perception; Naloxone DO - http://dx.doi.org/10.1016/j.pbb.2006.05.005 ER - TY - JOUR T1 - Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer-A Plan to Move Forward AN - 20214881; 6994837 AB - This article reviews progress in chemopreventive drug development, especially data and concepts that are new since the 2002 AACR report on treatment and prevention of intraepithelial neoplasia. Molecular biomarker expressions involved in mechanisms of carcinogenesis and genetic progression models of intraepithelial neoplasia are discussed and analyzed for how they can inform mechanism-based, molecularly targeted drug development as well as risk stratification, cohort selection, and end-point selection for clinical trials. We outline the concept of augmenting the risk, mechanistic, and disease data from histopathologic intraepithelial neoplasia assessments with molecular biomarker data. Updates of work in 10 clinical target organ sites include new data on molecular progression, significant completed trials, new agents of interest, and promising directions for future clinical studies. This overview concludes with strategies for accelerating chemopreventive drug development, such as integrating the best science into chemopreventive strategies and regulatory policy, providing incentives for industry to accelerate preventive drugs, fostering multisector cooperation in sharing clinical samples and data, and creating public-private partnerships to foster new regulatory policies and public education. JF - Clinical Cancer Research AU - Kelloff, Gary J AU - Lippman, Scott M AU - Dannenberg, Andrew J AU - Sigman, Caroline C AU - Pearce, Homer L AU - Reid, Brian J AU - Szabo, Eva AU - Jordan, VCraig AU - Spitz, Margaret R AU - Mills, Gordon B AU - Papadimitrakopoulou, Vali A AU - Lotan, Reuben AU - Aggarwal, Bharat B AU - Bresalier, Robert S AU - Kim, Jeri AU - Arun, Banu AU - Lu, Karen H AU - Thomas, Melanie E AU - Rhodes, Helen E AU - Brewer, Molly A AU - Follen, Michele AU - Shin, Dong M AU - Parnes, Howard L AU - Siegfried, Jill M AU - Evans, Alison A AU - Blot, William J AU - Chow, Wong-Ho AU - Blount, Patricia L AU - Maley, Carlo C AU - Wang, Kenneth K AU - Lam, Stephen AU - Lee, JJack AU - Dubinett, Steven M AU - Engstrom, Paul F AU - Meyskens, Frank LJr AU - O'Shaughnessy, Joyce AU - Hawk, Ernest T AU - Levin, Bernard AU - Nelson, William G AU - Hong, Waun Ki AD - Authors' Affiliations: National Cancer Institute, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3661 EP - 3697 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 12 SN - 1078-0432, 1078-0432 KW - Biotechnology Research Abstracts (through 1992) KW - Molecular modelling KW - Cooperation KW - Reviews KW - Carcinogenesis KW - Drug development KW - Clinical trials KW - biomarkers KW - Neoplasia KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20214881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Progress+in+Chemoprevention+Drug+Development%3A+The+Promise+of+Molecular+Biomarkers+for+Prevention+of+Intraepithelial+Neoplasia+and+Cancer-A+Plan+to+Move+Forward&rft.au=Kelloff%2C+Gary+J%3BLippman%2C+Scott+M%3BDannenberg%2C+Andrew+J%3BSigman%2C+Caroline+C%3BPearce%2C+Homer+L%3BReid%2C+Brian+J%3BSzabo%2C+Eva%3BJordan%2C+VCraig%3BSpitz%2C+Margaret+R%3BMills%2C+Gordon+B%3BPapadimitrakopoulou%2C+Vali+A%3BLotan%2C+Reuben%3BAggarwal%2C+Bharat+B%3BBresalier%2C+Robert+S%3BKim%2C+Jeri%3BArun%2C+Banu%3BLu%2C+Karen+H%3BThomas%2C+Melanie+E%3BRhodes%2C+Helen+E%3BBrewer%2C+Molly+A%3BFollen%2C+Michele%3BShin%2C+Dong+M%3BParnes%2C+Howard+L%3BSiegfried%2C+Jill+M%3BEvans%2C+Alison+A%3BBlot%2C+William+J%3BChow%2C+Wong-Ho%3BBlount%2C+Patricia+L%3BMaley%2C+Carlo+C%3BWang%2C+Kenneth+K%3BLam%2C+Stephen%3BLee%2C+JJack%3BDubinett%2C+Steven+M%3BEngstrom%2C+Paul+F%3BMeyskens%2C+Frank+LJr%3BO%27Shaughnessy%2C+Joyce%3BHawk%2C+Ernest+T%3BLevin%2C+Bernard%3BNelson%2C+William+G%3BHong%2C+Waun+Ki&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2006-06-01&rft.volume=12&rft.issue=12&rft.spage=3661&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drug development; Neoplasia; biomarkers; Reviews; Clinical trials; Molecular modelling; Cooperation; Carcinogenesis ER - TY - JOUR T1 - MicroRNAs and cell differentiation in mammalian development AN - 20205879; 7596922 AB - MicroRNAs (miRNAs) are a group of recently discovered small RNAs produced by the cell using a unique process, involving RNA polymerase II, Microprocessor protein complex, and the RNAase III/Dicer endonuclease complex, and subsequently sequestered in an miRNA ribonucleoprotein complex. The biological functions of miRNAs depend on their ability to silence gene expression, primarily via degradation of the target mRNA and/or translational suppression, mediated by the RNA-induced silencing complex (RISC). First discovered in Caenorhabditis elegans (lin-4), miRNAs have now been identified in a wide array of organisms, including plants, zebrafish, Drosophila, and mammals. The expression of miRNAs in multicellular organisms exhibits spatiotemporal, and tissue- and cell-specificity, suggesting their involvement in tissue morphogenesis and cell differentiation. More than 200 miRNAs have been identified or predicted in mammalian cells. Recent studies have demonstrated the importance of miRNAs in embryonic stem cell differentiation, limb development, adipogenesis, myogenesis, angiogenesis and hematopoiesis, neurogenesis, and epithelial morphogenesis. Overexpression (gain-of-function) and inactivation (loss-of-function) are currently the primary approaches to studying miRNA functions. Another family of small RNAs related to miRNAs is the small interfering RNAs (siRNAs), generated by Dicer from long double-stranded RNAs (dsRNAs), and produced from an induced transgene, a viral intruder, or a rogue genetic element. siRNAs silence genes via either mRNA degradation, using the RISC, or DNA methylation. siRNAs are actively being applied in basic, functional genetic studies, particularly in the generation of gene knockdown animals, as well as in gene knockdown studies of cultured cells. These studies have provided invaluable information on the specific function(s) of individual genes. siRNA technology also presents exciting potential as a therapeutic approach in disease prevention and treatment, as suggested by a recent study targeting apolipoprotein B (ApoB) in primates. Further elucidation of how miRNAs and other small RNAs interact with known and yet-to-be identified gene regulatory pathways in the cell should provide us with a more in-depth understanding of the mechanisms regulating cellular function and differentiation, and facilitate the application of small RNA technology in disease control and treatment. Birth Defects Research (Part C) 78:140-149, 2006. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Song, Lin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch of the National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, tuanr@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 140 EP - 149 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 78 IS - 2 SN - 1542-975X, 1542-975X KW - Zebra danio KW - Zebra fish KW - Entomology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - myogenesis KW - Translation KW - Apolipoprotein B KW - Double-stranded RNA KW - Morphogenesis KW - Disease control KW - Angiogenesis KW - Gene expression KW - Differentiation KW - DNA-directed RNA polymerase KW - Stem cells KW - Neurogenesis KW - Mammalian cells KW - Embryo cells KW - Caenorhabditis elegans KW - DNA methylation KW - Congenital defects KW - RNA-induced silencing complex KW - Endonuclease KW - adipogenesis KW - miRNA KW - Transgenes KW - Primates KW - Danio rerio KW - Intruder KW - Limbs KW - siRNA KW - Ribonucleoproteins KW - Hemopoiesis KW - Drosophila KW - Gene silencing KW - W 30925:Genetic Engineering KW - Z 05360:Genetics and Evolution KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20205879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=MicroRNAs+and+cell+differentiation+in+mammalian+development&rft.au=Song%2C+Lin%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-06-01&rft.volume=78&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - myogenesis; Translation; Apolipoprotein B; Double-stranded RNA; Morphogenesis; Angiogenesis; Disease control; Gene expression; Differentiation; Neurogenesis; Stem cells; DNA-directed RNA polymerase; Embryo cells; Mammalian cells; DNA methylation; Congenital defects; RNA-induced silencing complex; adipogenesis; Endonuclease; Transgenes; miRNA; Intruder; Limbs; siRNA; Ribonucleoproteins; Hemopoiesis; Gene silencing; Danio rerio; Caenorhabditis elegans; Primates; Drosophila DO - http://dx.doi.org/10.1002/bdrc.20069 ER - TY - JOUR T1 - Mismatched siRNAs downregulate mRNAs as a function of target site location AN - 20165109; 7494646 AB - In mammalian cells, RNA interference can be mediated by synthetic duplex RNAs, termed small interfering RNAs (siRNAs), which assist in cleaving completely complementary mRNA transcripts. MicroRNAs (miRNAs) are endogenous small RNAs that assist in translationally repressing mRNAs with regions of partial complementarity, but may also reduce transcript levels. Since miRNAs predominantly interact with the 3' UTRs of transcripts, we sought to ask if mismatched siRNAs mimicking miRNAs affect cognate mRNA levels as a function of target site location. We find that mismatched siRNAs targeting the 3' UTRs of two endogenous transcripts yield a greater reduction in mRNA levels than those targeting the coding region. Our findings demonstrate the importance of target site location within endogenous mRNAs for small RNAs associated with RNAi. JF - FEBS Letters AU - Martin, Scott E AU - Caplen, Natasha J AD - Gene Silencing Section, Office of Science and Technology Partnerships, Office of the Director, CCR, NCI, NIH, Bethesda, MD 20892, United States, ncaplen@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3694 EP - 3698 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 580 IS - 15 SN - 0014-5793, 0014-5793 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - RNAi KW - siRNA KW - miRNA KW - 3' UTR KW - Translation KW - Mimicry KW - Mammalian cells KW - RNA-mediated interference KW - Site location KW - Complementarity KW - W 30940:Products KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20165109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Mismatched+siRNAs+downregulate+mRNAs+as+a+function+of+target+site+location&rft.au=Martin%2C+Scott+E%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2006-06-01&rft.volume=580&rft.issue=15&rft.spage=3694&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2006.05.056 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mimicry; Translation; Mammalian cells; siRNA; miRNA; RNA-mediated interference; Site location; Complementarity DO - http://dx.doi.org/10.1016/j.febslet.2006.05.056 ER - TY - JOUR T1 - Comparative genomics and structural biology of the molecular innovations of eukaryotes AN - 20135963; 6868631 AB - Eukaryotes encode numerous proteins that either have no detectable homologs in prokaryotes or have only distant homologs. These molecular innovations of eukaryotes may be classified into three categories: proteins and domains inherited from prokaryotic precursors without drastic changes in biochemical function, but often recruited for novel roles in eukaryotes; new superfamilies or distinct biochemical functions emerging within pre-existing protein folds; and domains with genuinely new folds, apparently 'invented' at the outset of eukaryotic evolution. Most new folds emerging in eukaryotes are either alpha - helical or stabilized by metal chelation. Comparative genomics analyses point to an early phase of rapid evolution, and dramatic changes between the origin of the eukaryotic cell and the advent of the last common ancestor of extant eukaryotes. Extensive duplication of numerous genes, with subsequent functional diversification, is a distinctive feature of this turbulent era. Evolutionary analysis of ancient eukaryotic proteins is generally compatible with a two- symbiont scenario for eukaryotic origin, involving an alpha -proteobacterium (the ancestor of the mitochondria) and an archaeon, as well as key contributions from their selfish elements. JF - Current Opinion in Structural Biology AU - Aravind, L AU - Iyer, Lakshminarayan M AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, aravind@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 409 EP - 419 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 3 SN - 0959-440X, 0959-440X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Metals KW - Symbionts KW - Reviews KW - Chelation KW - Genomic analysis KW - Mitochondria KW - genomics KW - Prokaryotes KW - Evolution KW - G 07740:Evolution KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20135963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Structural+Biology&rft.atitle=Comparative+genomics+and+structural+biology+of+the+molecular+innovations+of+eukaryotes&rft.au=Aravind%2C+L%3BIyer%2C+Lakshminarayan+M%3BKoonin%2C+Eugene+V&rft.aulast=Aravind&rft.aufirst=L&rft.date=2006-06-01&rft.volume=16&rft.issue=3&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Structural+Biology&rft.issn=0959440X&rft_id=info:doi/10.1016%2Fj.sbi.2006.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Symbionts; Reviews; Genomic analysis; Chelation; Mitochondria; Prokaryotes; genomics; Evolution DO - http://dx.doi.org/10.1016/j.sbi.2006.04.006 ER - TY - JOUR T1 - Cyanobacterial response regulator PatA contains a conserved N-terminal domain (PATAN) with an alpha-helical insertion AN - 20127654; 6945233 AB - The cyanobacterium Anabaena (Nostoc) PCC 7120 responds to starvation for nitrogen compounds by differentiating approximately every 10th cell in the filament into nitrogen-fixing cells called heterocysts. Heterocyst formation is subject to complex regulation, which involves an unusual response regulator PatA that contains a CheY-like phosphoacceptor (receiver, REC) domain at its C-terminus. PatA-like response regulators are widespread in cyanobacteria; one of them regulates phototaxis in Synechocystis PCC 6803. Sequence analysis of PatA revealed, in addition to the REC domain, a previously undetected, conserved domain, which we named PATAN (after PatA N-terminus), and a potential helix-turn-helix (HTH) domain. PATAN domains are encoded in a variety of environmental bacteria and archaea, often in several copies per genome, and are typically associated with REC, Roadblock and other signal transduction domains, or with DNA-binding HTH domains. Many PATAN domains contain insertions of a small additional domain, termed alpha -clip, which is predicted to form a four-helix bundle. PATAN domains appear to participate in protein-protein interactions that regulate gliding motility and processes of cell development and differentiation in cyanobacteria and some proteobacteria, such as Myxococcus xanthus and Geobacter sulfurreducens. Supplementary information: http://www.ncbi.nlm.nih.gov/Complete_Genomes/SigCensus/PATAN.html JF - Bioinformatics AU - Makarova, Kira S AU - Koonin, Eugene V AU - Haselkorn, Robert AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA. Department of Molecular Genetics and Cell Biology, University of Chicago Chicago, IL 60637, USA, galperin@ncbi.nlm.nih.gov Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 1297 EP - 1301 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 11 SN - 1367-4803, 1367-4803 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA Marine Biotechnology Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Archaea KW - Heterocysts KW - Anabaena KW - Geobacter sulfurreducens KW - Phototaxis KW - Proteobacteria KW - N-Terminus KW - Protein structure KW - Differentiation KW - Myxococcus xanthus KW - Conserved sequence KW - Filaments KW - Nostoc KW - Starvation KW - Synechocystis KW - Gliding KW - C-Terminus KW - CheY protein KW - Motility KW - Cyanobacteria KW - Bioinformatics KW - Cyanophyta KW - Protein interaction KW - Signal transduction KW - Nitrogen KW - Q4 27750:Environmental KW - J 02320:Cell Biology KW - K 03320:Cell Biology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20127654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Cyanobacterial+response+regulator+PatA+contains+a+conserved+N-terminal+domain+%28PATAN%29+with+an+alpha-helical+insertion&rft.au=Makarova%2C+Kira+S%3BKoonin%2C+Eugene+V%3BHaselkorn%2C+Robert%3BGalperin%2C+Michael+Y&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2006-06-01&rft.volume=22&rft.issue=11&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Starvation; Gliding; C-Terminus; Heterocysts; CheY protein; Phototaxis; N-Terminus; Protein structure; Differentiation; Motility; Conserved sequence; Bioinformatics; Filaments; Protein interaction; Nitrogen; Signal transduction; Synechocystis; Cyanobacteria; Myxococcus xanthus; Archaea; Anabaena; Geobacter sulfurreducens; Cyanophyta; Proteobacteria; Nostoc ER - TY - JOUR T1 - Microarray analysis of Bacillus cereus group virulence factors AN - 20076350; 6856161 AB - Bacillus cereus, B. thuringiensis and B. anthracis are closely related medically and economically important bacterial species that belong to the B. cereus group. Members of the B. cereus group carry genes encoding several important virulence factors, including enterotoxins, phospholipases and exotoxins. Since it is difficult to differentiate among B. cereus group members, and because Bacillus virulence factors are very important for pathogenesis, we explored the use of microarray-based detection of virulence factor genes as a tool for strain identification and for determining virulence. Our method requires an initial multiplex PCR amplification step, followed by identification of the PCR amplicons by hybridization to an oligonucleotide microarray containing genes for all three types of Bacillus virulence factors including B. anthracis virulence factors. The DNA chip described here contains 21 identical arrays used for analysis of seven samples in triplicates. Using the arrays, we found that virulence factors are present in several combinations in the strains analyzed. This work also demonstrates the potential of oligonucleotide microarrays for medical, food safety and biodefense analysis of microbial pathogens. JF - Journal of Microbiological Methods AU - Sergeev, N AU - Distler, M AU - Vargas, M AU - Chizhikov, V AU - Herold, KE AU - Rasooly, A AD - United States, rasoolya@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 488 EP - 502 VL - 65 IS - 3 SN - 0167-7012, 0167-7012 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - virulence factors KW - Food KW - Bacillus cereus KW - Polymerase chain reaction KW - phospholipase KW - Enterotoxins KW - Pathogens KW - Bacillus KW - Oligonucleotides KW - Exotoxins KW - J 02704:Enumeration KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20076350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=Microarray+analysis+of+Bacillus+cereus+group+virulence+factors&rft.au=Sergeev%2C+N%3BDistler%2C+M%3BVargas%2C+M%3BChizhikov%2C+V%3BHerold%2C+KE%3BRasooly%2C+A&rft.aulast=Sergeev&rft.aufirst=N&rft.date=2006-06-01&rft.volume=65&rft.issue=3&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2005.09.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - virulence factors; Food; Polymerase chain reaction; Enterotoxins; phospholipase; Pathogens; Oligonucleotides; Exotoxins; Bacillus cereus; Bacillus DO - http://dx.doi.org/10.1016/j.mimet.2005.09.013 ER - TY - JOUR T1 - Glucocorticoids Promote Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells by Enhancing Expression of Cartilage Extracellular Matrix Genes AN - 19986137; 6999317 AB - In the adult human, mesenchymal stem cells (hMSCs) resident in the bone marrow retain the capacity to proliferate and differentiate along multiple connective tissue lineages, including cartilage. Glucocorticoids (GCs) are required for chondrogenic differentiation of hMSCs in vitro; however, the exact role of GCs in this process is not known. In this study, we examined the effects of dexamethasone (DEX) on chondrogenic differentiation of hMSCs in the presence or absence of DEX, transforming growth factor-{szligbeta} (TGF-{szligbeta}), or DEX plus TGF-{szligbeta}. GC treatment upregulated gene expression of cartilage matrix components aggrecan, dermatopontin, and collagen type XI; enhanced TGF-{szligbeta}-mediated upregulation of collagen type II and cartilage oligomeric matrix protein; and increased aggrecan and collagen type II production as well as cartilage matrix-sulfated proteoglycans as assessed by immunohistochemistry and alcian blue staining. Inclusion of an antagonist of GCs inhibited expression of chondrogenic differentiation markers, suggesting that the GC effects during chondrogenesis are mediated by the GC receptor (GR). Steady levels of the major active form of GR, GR alpha , were detected in both undifferentiated and differentiating hMSCs, whereas the dominant-negative isoform GR{szligbeta}, present at low levels in undifferentiated hMSCs, was downregulated during chondrogenesis. In the presence of DEX and TGF-{szligbeta}, expression of a collagen type II gene promoter luciferase reporter construct in hMSCs was upregulated. However, coexpression of GR{szligbeta} dramatically inhibited promoter activity, suggesting that GR alpha is required for GC-mediated modulation of chondrogenesis and that GCs may play an important role in the maintenance of cartilage homeostasis. JF - Stem Cells AU - Derfoul, Assia AU - Perkins, Geraldine L AU - Hall, David J AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, Cartilage Genetics Group, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1487 EP - 1495 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Calcium & Calcified Tissue Abstracts KW - Cartilage oligomeric matrix protein KW - Dexamethasone KW - Connective tissues KW - Cartilage KW - Bone marrow KW - Glucocorticoids KW - Proteoglycans KW - Promoters KW - Stem cells KW - Extracellular matrix KW - Collagen (type II) KW - aggrecan KW - Mesenchyme KW - Immunohistochemistry KW - Chondrogenesis KW - G 07880:Human Genetics KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Glucocorticoids+Promote+Chondrogenic+Differentiation+of+Adult+Human+Mesenchymal+Stem+Cells+by+Enhancing+Expression+of+Cartilage+Extracellular+Matrix+Genes&rft.au=Derfoul%2C+Assia%3BPerkins%2C+Geraldine+L%3BHall%2C+David+J%3BTuan%2C+Rocky+S&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Cartilage oligomeric matrix protein; Connective tissues; Cartilage; Bone marrow; Glucocorticoids; Proteoglycans; Promoters; Stem cells; Extracellular matrix; Collagen (type II); Mesenchyme; aggrecan; Immunohistochemistry; Chondrogenesis ER - TY - JOUR T1 - Pharmacokinetics and Safety of Oral Posaconazole in Neutropenic Stem Cell Transplant Recipients AN - 19971362; 6944484 AB - The pharmacokinetics of posaconazole oral suspension in neutropenic patients undergoing high-dose chemotherapy and stem cell transplantation were evaluated, and the association of plasma posaconazole exposure with the presence and severity of oral mucositis was explored in this nonrandomized, open-label, parallel-group, multiple-dose pharmacokinetic study. Thirty patients were enrolled and received one of three regimens (group I, 200 mg once daily; group II, 400 mg once daily; group III, 200 mg four times daily) for the duration of neutropenia. The mean total exposure for day 1, as shown by the area under the concentration-time curve from 0 to 24 h (AUC sub(0-24)), was 1.96 mg . h/liter in group I and was 51% higher in group II and in group III. Increases in AUC sub(0-24) and maximum plasma concentration (C sub(max)) in groups II and III were dose related. The AUC sub(0-24) and C sub(max) values on day 1 were similar between groups II and III. There was interpatient variability of up to 68% in the pharmacokinetic values for our study population. Steady state was attained by days 5 to 6. Average steady-state plasma posaconazole trough values were 192, 219, and 414 ng/ml in groups I, II, and III, respectively. The AUC sub(0-24) and apparent oral clearance increased by increasing dose and dosing frequency. Mucositis appeared to reduce exposure but did not significantly affect mean total posaconazole exposure (AUC and C sub(max)) at steady state (P = 0.1483). Moreover, this reduction could be overcome by increasing the total dose and dosing frequency. Posaconazole was safe and well tolerated. JF - Antimicrobial Agents & Chemotherapy AU - Gubbins, Paul O AU - Krishna, Gopal AU - Sansone-Parsons, Angela AU - Penzak, Scott R AU - Dong, Li AU - Martinho, Monika AU - Anaissie, Elias J AD - College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Schering-Plough Research Institute, Kenilworth, New Jersey. National Institutes of Health, Clinical Pharmacokinetics Laboratory, Clinical Center Pharmacy Department, Bethesda, Maryland. Myeloma Institute for Research and Therapy, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1993 EP - 1999 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Neutropenia KW - Mucositis KW - Chemotherapy KW - stem cell transplantation KW - Population studies KW - Posaconazole KW - Pharmacokinetics KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19971362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+and+Safety+of+Oral+Posaconazole+in+Neutropenic+Stem+Cell+Transplant+Recipients&rft.au=Gubbins%2C+Paul+O%3BKrishna%2C+Gopal%3BSansone-Parsons%2C+Angela%3BPenzak%2C+Scott+R%3BDong%2C+Li%3BMartinho%2C+Monika%3BAnaissie%2C+Elias+J&rft.aulast=Gubbins&rft.aufirst=Paul&rft.date=2006-06-01&rft.volume=50&rft.issue=6&rft.spage=1993&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neutropenia; Mucositis; stem cell transplantation; Chemotherapy; Population studies; Posaconazole; Pharmacokinetics ER - TY - JOUR T1 - In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques AN - 19964604; 6999323 AB - Immunodeficiency after peripheral blood progenitor cell (PBPC) transplantation may be influenced by graft composition, underlying disease, and/or pre-treatment. These factors are difficult to study independently in humans. Ex vivo culture and genetic manipulation of PBPC grafts may also affect immune reconstitution, with relevance to gene therapy applications. We directly compared the effects of three clinically relevant autologous graft compositions on immune reconstitution after myeloblative total body irradiation in rhesus macaques, the first time these studies have been performed in a large animal model with direct clinical relevance. Animals received CD34 super(+) cell dose-matched grafts of either peripheral blood mononuclear cells, purified CD34 super(+) PBPCs, or purified CD34 super(+) PBPCs expanded in vitro and retrovirally transduced. We evaluated the reconstitution of T, B, natural killer, dendritic cells, and monocytes in blood and lymph nodes for up to 1 year post-transplantation. Animals receiving selected-transduced CD34 super(+) cells had the fastest recovery of T-cell numbers, along with the highest T-cell-receptor gene rearrangement excision circles levels, the fewest proliferating Ki-67 super(+) T-cells in the blood, and the best-preserved thymic architecture. Selected-transduced CD34 super(+) cells may therefore repopulate the thymus more efficiently and promote a higher output of naive T-cells. These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation. JF - Stem Cells AU - Lore, Karin AU - Seggewiss, Ruth AU - Guenaga, FJavier AU - Pittaluga, Stefania AU - Donahue, Robert E AU - Krouse, Allen AU - Metzger, Mark E AU - Koup, Richard A AU - Reilly, Cavan AU - Douek, Daniel C AU - Dunbar, Cynthia E AD - Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland. Hematopathology Section, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland. Division of Biostatistics, University of Minnesota, Twin Cities, Minnesota Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1539 EP - 1548 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 6 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Gene therapy KW - Thymus KW - Animal models KW - Immunodeficiency KW - Natural killer cells KW - Cell culture KW - CD34 antigen KW - Clinical trials KW - Lymph nodes KW - Immune reconstitution KW - Dendritic cells KW - Stem cells KW - Peripheral blood mononuclear cells KW - Radiation KW - gene rearrangement KW - Lymphocytes T KW - Hemopoiesis KW - Macaca mulatta KW - Monocytes KW - W 30905:Medical Applications KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=In+Vitro+Culture+During+Retroviral+Transduction+Improves+Thymic+Repopulation+and+Output+After+Total+Body+Irradiation+and+Autologous+Peripheral+Blood+Progenitor+Cell+Transplantation+in+Rhesus+Macaques&rft.au=Lore%2C+Karin%3BSeggewiss%2C+Ruth%3BGuenaga%2C+FJavier%3BPittaluga%2C+Stefania%3BDonahue%2C+Robert+E%3BKrouse%2C+Allen%3BMetzger%2C+Mark+E%3BKoup%2C+Richard+A%3BReilly%2C+Cavan%3BDouek%2C+Daniel+C%3BDunbar%2C+Cynthia+E&rft.aulast=Lore&rft.aufirst=Karin&rft.date=2006-06-01&rft.volume=24&rft.issue=6&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Thymus; Natural killer cells; Immunodeficiency; Animal models; CD34 antigen; Cell culture; Clinical trials; Lymph nodes; Immune reconstitution; Dendritic cells; Peripheral blood mononuclear cells; Stem cells; Radiation; gene rearrangement; Lymphocytes T; Hemopoiesis; Monocytes; Macaca mulatta ER - TY - JOUR T1 - CANCER STEM CELLS: Redefining the Paradigm of Cancer Treatment Strategies AN - 19960542; 6998152 AB - Cancer has been known to arise from long-lived cells in the body and to possess properties in common with undifferentiated, embryonic cells. Recent findings of a population of cells in solid tumors resembling stem cells supports a stem cell model of cancer. A scheme in which all cancers initiate from "activated" stem cells helps bring together data from genetic, cell biology, and epidemiology studies. Cancer can arise from embryonic cells in the case of childhood tumors; hormone-activated stem cells in the case of breast cancer; and following chronic activation of stem cells caused by tissue damage. This scheme helps explain the failure of many cancer therapies, points out deficiencies in certain research approaches, and focuses the problem on a subset of cells that can be explicitly targeted, leading to more efficient therapy. JF - Molecular Interventions AU - Dean, Michael AD - National Cancer Institute-Frederick Cancer Research and Development Center, Bldg 560, Frederick, MD 21702 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 140 EP - 148 PB - American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike Bethesda MD 20814-3995 USA, [mailto:info@aspet.org], [URL:http://www.aspet.org] VL - 6 IS - 3 SN - 1534-0384, 1534-0384 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Data processing KW - Epidemiology KW - Solid tumors KW - Breast cancer KW - Embryos KW - Cell culture KW - Tumors KW - Children KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Interventions&rft.atitle=CANCER+STEM+CELLS%3A+Redefining+the+Paradigm+of+Cancer+Treatment+Strategies&rft.au=Dean%2C+Michael&rft.aulast=Dean&rft.aufirst=Michael&rft.date=2006-06-01&rft.volume=6&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Molecular+Interventions&rft.issn=15340384&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Data processing; Epidemiology; Solid tumors; Breast cancer; Cell culture; Embryos; Tumors; Children ER - TY - JOUR T1 - Antimicrosporidial Activities of Fumagillin, TNP-470, Ovalicin, and Ovalicin Derivatives In Vitro and In Vivo AN - 19952972; 6944504 AB - Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective antimicrosporidial drug, is considered to be moderately toxic. The purpose of this study was to apply an in vitro drug screening assay for Encephalitozoon intestinalis and Vittaforma corneae and an in vivo athymic mouse model of V. corneae infection to assess the efficacy of TNP-470 (a semisynthetic analogue of fumagillin), ovalicin, and eight ovalicin derivatives. TNP-470, ovalicin, and three of the ovalicin derivatives inhibited both E. intestinalis and V. corneae replication by more than 70% in vitro. Another three of the ovalicin derivatives inhibited one of the two microsporidian species by more than 70%. None of the treated athymic mice survived the V. corneae infection, but they did survive statistically significantly longer than the untreated controls after daily treatment with fumagillin administered at 5, 10, and 20 mg/kg of body weight subcutaneously (s.c.), TNP-470 administered at 20 mg/kg intraperitoneally (i.p.), or ovalicin administered at 5 mg/kg s.c. Of two ovalicin derivatives that were assessed in vivo, NSC 9665 given at 10 mg/kg i.p. daily also statistically significantly prolonged survival of the mice. No lesions associated with drug toxicity were observed in the kidneys or livers of uninfected mice treated with these drugs at the highest dose of 20 mg/kg daily. These results thus support continued studies to identify more effective fumagillin-related drugs for treating microsporidiosis. JF - Antimicrobial Agents & Chemotherapy AU - Didier, Peter J AU - Phillips, Jennifer N AU - Kuebler, Dorothy J AU - Nasr, Mohamed AU - Brindley, Paul J AU - Stovall, Mary E AU - Bowers, Lisa C AU - Didier, E S AD - Divisions of Comparative Pathology. Microbiology, Tulane National Primate Research Center, Tulane University, Covington, Louisiana. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 2146 EP - 2155 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Replication KW - Animal models KW - Survival KW - Toxicity KW - Encephalitozoon intestinalis KW - Infection KW - Drug screening KW - Antimicrobial agents KW - Body weight KW - Vittaforma corneae KW - Kidney KW - Liver KW - Drugs KW - Microsporidiosis KW - A 01340:Antibiotics & Antimicrobials KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19952972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antimicrosporidial+Activities+of+Fumagillin%2C+TNP-470%2C+Ovalicin%2C+and+Ovalicin+Derivatives+In+Vitro+and+In+Vivo&rft.au=Didier%2C+Peter+J%3BPhillips%2C+Jennifer+N%3BKuebler%2C+Dorothy+J%3BNasr%2C+Mohamed%3BBrindley%2C+Paul+J%3BStovall%2C+Mary+E%3BBowers%2C+Lisa+C%3BDidier%2C+E+S&rft.aulast=Didier&rft.aufirst=Peter&rft.date=2006-06-01&rft.volume=50&rft.issue=6&rft.spage=2146&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Body weight; Replication; Liver; Animal models; Kidney; Survival; Toxicity; Drug screening; Infection; Drugs; Microsporidiosis; Antimicrobial agents; Vittaforma corneae; Encephalitozoon intestinalis ER - TY - JOUR T1 - Functional Correlation between a Novel Amino Acid Insertion at Codon 19 in the Protease of Human Immunodeficiency Virus Type 1 and Polymorphism in the p1/p6 Gag Cleavage Site in Drug Resistance and Replication Fitness AN - 19922366; 6948834 AB - Population-based sequence analysis revealed the presence of a variant of human immunodeficiency virus type 1 (HIV-1) containing an insertion of amino acid Ile in the protease gene at codon 19 (19I) and amino acid substitutions in the protease at codons 21 (E21D) and 22 (A22V) along with multiple mutations associated with drug resistance, M46I/P63L/A71V/I84V/I93L, in a patient who had failed protease inhibitor (PI) therapy. Longitudinal analysis revealed that the P63L/A71V/I93L changes were present prior to PI therapy. Polymorphisms in the Gag sequence were only seen in the p1/p6 cleavage site at the P1' position (Leu to Pro) and the P5' position (Pro to Leu). To characterize the role of these mutations in drug susceptibility and replication capacity, a chimeric HIV-1 strain containing the 19I/E21D/A22V mutations with the M46I/P63L/A71V/I84V/I93L and p1/p6 mutations was constructed. The chimera displayed high-level resistance to multiple PIs, but not to lopinavir, and grew to 30% of that of the wild type. To determine the relative contribution of each mutation to the phenotypic characteristic of the virus, a series of mutants was constructed using site-directed mutagenesis. A high level of resistance was only seen in mutants containing the 19I/A22V and p1/p6 mutations. The E21D mutation enhanced viral replication. These results suggest that the combination of the 19I/E21D/A22V mutations may emerge and lead to high-level resistance to multiple PIs. The combination of the 19I/A22V mutations may be associated with PI resistance; however, the drug resistance may be caused by the presence of a unique set of mutations in the p1/p6 mutations. The E21D mutation contributes to replication fitness rather than drug resistance. JF - Journal of Virology AU - Brann, Terrence W AU - Dewar, Robin L AU - Jiang, Min-Kan AU - Shah, Akram AU - Nagashima, Kunio AU - Metcalf, Julia A AU - Falloon, Judith AU - Lane, HClifford AU - Imamichi, Tomozumi AD - Laboratory of Human Retrovirology. Virus Isolation and Serology Laboratory. Image Analysis Laboratory, Science Applications International Corporation-Frederick, Inc., Frederick, Maryland. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 6136 EP - 6145 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 12 SN - 0022-538X, 0022-538X KW - HIV-1 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Virology & AIDS Abstracts KW - Site-directed mutagenesis KW - Fitness KW - Amino acid substitution KW - Replication KW - Drug resistance KW - Proteinase inhibitors KW - Gag protein KW - Chimeras KW - Lopinavir KW - Insertion KW - Human immunodeficiency virus 1 KW - Codons KW - Mutation KW - Amino acid sequence KW - V 22002:AIDS: Molecular and in vitro aspects KW - G 07313:Viruses KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19922366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Functional+Correlation+between+a+Novel+Amino+Acid+Insertion+at+Codon+19+in+the+Protease+of+Human+Immunodeficiency+Virus+Type+1+and+Polymorphism+in+the+p1%2Fp6+Gag+Cleavage+Site+in+Drug+Resistance+and+Replication+Fitness&rft.au=Brann%2C+Terrence+W%3BDewar%2C+Robin+L%3BJiang%2C+Min-Kan%3BShah%2C+Akram%3BNagashima%2C+Kunio%3BMetcalf%2C+Julia+A%3BFalloon%2C+Judith%3BLane%2C+HClifford%3BImamichi%2C+Tomozumi&rft.aulast=Brann&rft.aufirst=Terrence&rft.date=2006-06-01&rft.volume=80&rft.issue=12&rft.spage=6136&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fitness; Site-directed mutagenesis; Amino acid substitution; Replication; Drug resistance; Proteinase inhibitors; Gag protein; Chimeras; Lopinavir; Insertion; Codons; Mutation; Amino acid sequence; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Response of microbial activities to heavy metals in a neutral loamy soil treated with biosolid AN - 19877637; 7489079 AB - Application of biosolid on land has been widespread in numerous countries for last several decades. This study performed incubation experiments by mixing a neutral loamy soil and biosolid enriched in Cu, Pb and Zn to explore how heavy metal affects soil mineralization and microbial biomass. The experimental results indicated that large nutrient, microorganism and C sources from biosolid were beneficial to microbial respiration. However, compared to the biosolid alone treatment, the supplemented Cu, Pb and Zn in biosolid reduced the mineralized C by roughly 36%. This phenomenon was probably caused by a portion of the Cu, Pb and Zn being complexed with organic matter to prevent decomposition of organic carbon by microorganisms. Equally, soil treated with biosolid increased the quantity of mineralized N by approximately five-fold and accelerated the rate of N mineralization by about one-fold compared to untreated soil. Notably, addition of heavy metals impaired the mineralization process, particularly when Pb reached about 64%. The reduced N mineralization occurred for similar reasons to the microbial respiration. The addition of biosolid in soil considerably increased the amount of mineralizable N; however, the increase was lower in biosolid-treated soil spiked by heavy metals. The addition of heavy metals in the soil-biosolid mixture clearly reduced the microbial biomasses C (MBC) and N (MBN), indicating that the microbial activities had been disrupted by the heavy metals. The microbial biomass C/N ratio had changed initially from 8 to 13 at the end of incubation period, owing to various groups of microbes expressing different mechanisms of metabolism, indicating that the microbial population had changed from bacteria to fungi, which had higher metal tolerance. JF - Chemosphere AU - Kao, Po-Hsu AU - Huang, Cheng-Chieh AU - Hseu, Zeng-Yei AD - Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei Pu, Pingtung 91201, Taiwan, zyhseu@mail.npust.edu.tw Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 63 EP - 70 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 64 IS - 1 SN - 0045-6535, 0045-6535 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Pollution Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Biosolid KW - Heavy metals KW - Microbial biomass KW - Microbial respiration KW - Mineralization KW - Respiration KW - Organic carbon KW - Nutrients KW - Copper KW - Decomposition KW - Lead KW - Soil microorganisms KW - Soil KW - Carbon KW - Zinc KW - Biosolids KW - heavy metals KW - Metals KW - Pollution tolerance KW - Organic matter KW - Fungi KW - Microbial activity KW - Biomass KW - Microorganisms KW - biosolids KW - Metabolism KW - P 5000:LAND POLLUTION KW - K 03320:Cell Biology KW - A 01400:Soil Microbes KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19877637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Response+of+microbial+activities+to+heavy+metals+in+a+neutral+loamy+soil+treated+with+biosolid&rft.au=Kao%2C+Po-Hsu%3BHuang%2C+Cheng-Chieh%3BHseu%2C+Zeng-Yei&rft.aulast=Kao&rft.aufirst=Po-Hsu&rft.date=2006-06-01&rft.volume=64&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2005.11.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heavy metals; Fungi; Respiration; Organic matter; Nutrients; Copper; Mineralization; Biomass; Decomposition; Lead; Soil microorganisms; Soil; Carbon; Zinc; biosolids; Microorganisms; Metabolism; Pollution tolerance; Metals; Organic carbon; Microbial activity; Biosolids; heavy metals DO - http://dx.doi.org/10.1016/j.chemosphere.2005.11.039 ER - TY - JOUR T1 - Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice AN - 19855426; 6994357 AB - The effect of prolonged antibiotic treatments on tumor development was evaluated in proto-neu transgenic mice, which spontaneously develop mammary carcinomas. Virgin transgenic mice were treated with metronidazole/ciprofloxacin or gentamicin through the drinking water. The hazard ratio [HR; 95% confidence interval (95% CI)] of breast cancer occurrence in metronidazole/ciprofloxacin-treated mice was more than triple that for controls [3.11 (1.13-8.53); P = 0.028], whereas only a slight increase in HR (95% CI) was observed in gentamicin-treated mice [1.39 (0.56-3.47); P = 0.481]. Tumor growth rate in gentamicin-treated mice was significantly faster than in untreated control mice (P = 0.043). Moreover, mammary glands from mice treated with either antibiotic regimen showed increased lobulization, with more numerous and more developed terminal ductal lobular units than in controls. These results indicate that prolonged exposure to relevant doses of antibiotics affects the mammary glands in this particular model of HER-2/neu transgenic mice; further studies to understand the precise mechanism by which antibiotic treatments influence mammary gland differentiation are critical. (Cancer Res 2006; (12): 6219-24) JF - Cancer Research AU - Rossini, Anna AU - Rumio, Cristiano AU - Sfondrini, Lucia AU - Tagliabue, Elda AU - Morelli, Daniele AU - Miceli, Rosalba AU - Mariani, Luigi AU - Palazzo, Marco AU - Menard, Sylvie AU - Balsari, Andrea AD - Molecular Targeting Unit, Medicine Laboratory Unit, and Unit of Medical Statistics and Biometry, Department of Experimental Oncology and Laboratories, National Cancer Institute Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 6219 EP - 6224 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 12 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Metronidazole KW - ErbB-2 protein KW - Mammary gland KW - Animal models KW - Antibiotics KW - Tumors KW - Transgenic mice KW - Carcinoma KW - Gentamicin KW - Differentiation KW - Ciprofloxacin KW - Breast carcinoma KW - Drinking water KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19855426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Influence+of+Antibiotic+Treatment+on+Breast+Carcinoma+Development+in+Proto-neu+Transgenic+Mice&rft.au=Rossini%2C+Anna%3BRumio%2C+Cristiano%3BSfondrini%2C+Lucia%3BTagliabue%2C+Elda%3BMorelli%2C+Daniele%3BMiceli%2C+Rosalba%3BMariani%2C+Luigi%3BPalazzo%2C+Marco%3BMenard%2C+Sylvie%3BBalsari%2C+Andrea&rft.aulast=Rossini&rft.aufirst=Anna&rft.date=2006-06-01&rft.volume=66&rft.issue=12&rft.spage=6219&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Growth rate; Metronidazole; ErbB-2 protein; Mammary gland; Animal models; Antibiotics; Tumors; Transgenic mice; Carcinoma; Gentamicin; Ciprofloxacin; Differentiation; Breast carcinoma; Drinking water ER - TY - JOUR T1 - Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect AN - 19846181; 6948820 AB - APOBEC3G (APO3G), a cytidine deaminase with two zinc finger domains, inhibits human immunodeficiency virus type 1 replication in the absence of Vif. Here, we provide a comprehensive molecular analysis of the deaminase and nucleic acid binding activities of human APO3G using a pure system containing only one protein component, i.e., highly purified, catalytically active enzyme expressed in a baculovirus system. We demonstrate that APO3G deaminates cytosines in single-stranded DNA (ssDNA) only, whereas it binds efficiently to ssDNA and ssRNA, about half as well to a DNA/RNA hybrid, and poorly to double-stranded DNA and RNA. In addition, the base specificities for deamination and binding of ssDNA are not correlated. The minimum length required for detection of APO3G binding to an ssDNA oligonucleotide in an electrophoretic mobility shift assay is 16 nucleotides. Interestingly, if nucleocapsid protein and APO3G are present in the same reaction, we find that they do not interfere with each other's binding to RNA and a complex containing the RNA and both proteins is formed. Finally, we also identify the functional activities of each zinc finger domain. Thus, although both zinc finger domains have the ability to bind nucleic acids, the first zinc finger contributes more to binding and APO3G encapsidation into virions than finger two. In contrast, deamination is associated exclusively with the second zinc finger. Moreover, zinc finger two is more important than finger one for the antiviral effect, demonstrating a correlation between deaminase and antiviral activities. JF - Journal of Virology AU - Iwatani, Yasumasa AU - Takeuchi, Hiroaki AU - Strebel, Klaus AU - Levin, Judith G AD - Laboratory of Molecular Genetics, National Institute of Child Health and Human Development. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 5992 EP - 6002 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 12 SN - 0022-538X, 0022-538X KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Virions KW - Replication KW - Double-stranded RNA KW - Deamination KW - Enzymes KW - Encapsidation KW - Zinc finger proteins KW - Antiviral activity KW - Electrophoretic mobility KW - Oligonucleotides KW - Nucleotides KW - Cytosine KW - nucleic acids KW - RNA KW - Hybrids KW - Human immunodeficiency virus 1 KW - Nucleocapsids KW - Baculovirus KW - Cytidine deaminase KW - A 01340:Antibiotics & Antimicrobials KW - V 22002:AIDS: Molecular and in vitro aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19846181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Biochemical+Activities+of+Highly+Purified%2C+Catalytically+Active+Human+APOBEC3G%3A+Correlation+with+Antiviral+Effect&rft.au=Iwatani%2C+Yasumasa%3BTakeuchi%2C+Hiroaki%3BStrebel%2C+Klaus%3BLevin%2C+Judith+G&rft.aulast=Iwatani&rft.aufirst=Yasumasa&rft.date=2006-06-01&rft.volume=80&rft.issue=12&rft.spage=5992&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Replication; Double-stranded RNA; Deamination; Zinc finger proteins; Encapsidation; Enzymes; Electrophoretic mobility; Antiviral activity; Oligonucleotides; Nucleotides; Cytosine; nucleic acids; RNA; Hybrids; Nucleocapsids; Cytidine deaminase; Human immunodeficiency virus 1; Baculovirus ER - TY - JOUR T1 - p53 Transgenic Mice Are Highly Susceptible to 4-Nitroquinoline-1-Oxide-Induced Oral Cancer AN - 19844459; 6998109 AB - In this study, we did a bioassay employing mice with a dominant-negative p53 mutation (p53 super(Val135/WT)) to assess whether a germ-line p53 mutation predisposed mice toward the development of squamous cell carcinomas (SCC) in the oral cavity. Treatment of the mouse oral cavity with 4-nitroquinoline-1-oxide produced a 66%, 91%, and 20% tumor incidence in the oral cavity, esophagus, and forestomach/stomach, respectively, in p53 super(Val135/WT) mice. In contrast, only a 25%, 58%, and 4% tumor incidence was observed in oral cavity, esophagus, and forestomach/stomach, respectively, in wild-type littermates (p53 super(WT/WT)). The most striking difference between p53 super(Val135/WT) and p53 super(WT/WT) mice following the carcinogen treatment was the higher prevalence and more rapid development of SSC in p53 super(Val135/WT) mice than in wild-type mice. To identify the precise genes or pathways involved in these differences during tumor development, we examined gene expression profiles of 4-nitroquinoline-1-oxide-treated normal tongues as well as tongue SCC in p53 super(Val135/WT) and p53 super(WT/WT) mice. Microarray and GenMAPP analysis revealed that dominant-negative p53 ( super(135)Valp53) affects several cellular processes involved in SCC development. Affected processes included apoptosis and cell cycle arrest pathways, which were modulated in both tumor and normal epithelium. These results showed that reduction of p53-dependent apoptosis and increases in cell proliferation might contribute to the observed increase in oral cavity and gastroesophageal malignancies in p53 super(Val135/WT) mice as well as to the more rapid growth and progression of tumors. (Mol Cancer Res 2006; 4(6):401-10) JF - Molecular Cancer Research AU - Zhang, Zhongqiu AU - Wang, Yian AU - Yao, Ruisheng AU - Lubet, Ronald A AU - You, Ming AD - Department of Surgery, Washington University School of Medicine, St. Louis, Missouri and Chemoprevention Agent Development Research Group, National Cancer Institute, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 401 EP - 410 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 4 IS - 6 SN - 1541-7786, 1541-7786 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Esophagus KW - Apoptosis KW - Cell cycle KW - squamous cell carcinoma KW - Carcinogens KW - Tumors KW - Development KW - Transgenic mice KW - Cancer KW - Oral cavity KW - p53 protein KW - Gene expression KW - Malignancy KW - Tongue KW - Epithelium KW - Cell proliferation KW - Mutation KW - Stomach KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Research&rft.atitle=p53+Transgenic+Mice+Are+Highly+Susceptible+to+4-Nitroquinoline-1-Oxide-Induced+Oral+Cancer&rft.au=Zhang%2C+Zhongqiu%3BWang%2C+Yian%3BYao%2C+Ruisheng%3BLubet%2C+Ronald+A%3BYou%2C+Ming&rft.aulast=Zhang&rft.aufirst=Zhongqiu&rft.date=2006-06-01&rft.volume=4&rft.issue=6&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Research&rft.issn=15417786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Esophagus; Apoptosis; Cell cycle; squamous cell carcinoma; Development; Tumors; Carcinogens; Transgenic mice; Oral cavity; Cancer; p53 protein; Gene expression; Malignancy; Epithelium; Tongue; Cell proliferation; Mutation; Stomach ER - TY - JOUR T1 - Type I Interferons are essential for the efficacy of replicase-based DNA vaccines AN - 19843561; 6868912 AB - The immunogenicity and efficacy of nucleic acid vaccines can be greatly enhanced when antigen production is under the control of an alphaviral replicase enzyme. However, replicase-mediated mRNA overproduction does not necessarily result in enhanced antigen level. Instead, the strong adaptive immune response of alphavirus replicon-based vectors is due to their production of double- stranded RNA (dsRNA) intermediates, which trigger innate immunity. Because viral infections are known to trigger innate immune responses that lead to the rapid production of Type I Interferons (IFNs), namely IFN- alpha and IFN- beta , we investigated the role of Type I IFNs in the enhanced immunogenicity of replicase-based DNA vaccines. In vitro, cells transfected with replicase-based plasmids produce significantly more Type I IFNs than cells transfected with a conventional DNA plasmid. In vivo, replicase-based DNA vaccines yield stronger humoral responses in the absence of Type I IFN signaling but the lack of this signaling pathway in IFN- alpha beta receptor-/- (knockout) mice abolishes T cell mediated efficacy against tumors of both conventional and alphavirus replicase- based DNA vaccines. Moreover, the co-delivery of an IFN alpha -encoding plasmid significantly improved the efficacy of a weakly immunogenic conventional plasmid. These results suggest a central role for Type I IFNs in the mechanism of replicase-based DNA vaccines and indicate that vaccines can be enhanced by enabling their capacity to triggering innate anti-viral defense pathways. JF - Vaccine AU - Leitner, Wolfgang W AU - Bergmann-Leitner, Elke S AU - Hwang, Leroy N AU - Restifo, Ni AD - Clinical Research Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, wolfgang_leitner@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 5110 EP - 5118 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 24 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - DNA vaccines KW - Alphavirus KW - Type I IFN KW - Tumor therapy KW - beta -Interferon KW - Double-stranded RNA KW - Enzymes KW - Tumors KW - Immunity KW - Plasmids KW - Infection KW - replicase KW - mRNA KW - Interferon KW - nucleic acids KW - Antiviral agents KW - Immunogenicity KW - alpha -Interferon KW - Lymphocytes T KW - Vaccines KW - Immune response KW - Signal transduction KW - V 22350:Immunology KW - F 06100:Vaccines - active immunity KW - N 14830:RNA KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Type+I+Interferons+are+essential+for+the+efficacy+of+replicase-based+DNA+vaccines&rft.au=Leitner%2C+Wolfgang+W%3BBergmann-Leitner%2C+Elke+S%3BHwang%2C+Leroy+N%3BRestifo%2C+Ni&rft.aulast=Leitner&rft.aufirst=Wolfgang&rft.date=2006-06-01&rft.volume=24&rft.issue=24&rft.spage=5110&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.04.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Double-stranded RNA; Enzymes; Immunity; Tumors; Infection; Plasmids; replicase; mRNA; Interferon; nucleic acids; DNA vaccines; Antiviral agents; Immunogenicity; alpha -Interferon; Lymphocytes T; Immune response; Vaccines; Signal transduction; Alphavirus DO - http://dx.doi.org/10.1016/j.vaccine.2006.04.059 ER - TY - JOUR T1 - Detection of Carcinogenic Human Papillomavirus in Specimens Collected with a Novel Self-Sampling Device AN - 19831081; 6947931 AB - We compared the detection of carcinogenic human papillomavirus DNA in cervicovaginal specimens self-collected using a novel device to the detection in physician-collected cervical specimens from 137 women. The kappa value was 0.66 (95% confidence interval, 0.53 to 0.78), with an 83% overall test agreement and a 68% positive test agreement. JF - Journal of Clinical Microbiology AU - Castle, Philip E AU - Aftab, Asma AU - Saint-Jean, Gilbert AU - Mendez, Luis AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, and Departments of. Family Medicine and Community Health. Epidemiology and Public Health. Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 2158 EP - 2159 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 6 SN - 0095-1137, 0095-1137 KW - Toxicology Abstracts; Virology & AIDS Abstracts KW - DNA KW - Cervix KW - Human papillomavirus KW - V 22121:Diagnosis KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19831081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Detection+of+Carcinogenic+Human+Papillomavirus+in+Specimens+Collected+with+a+Novel+Self-Sampling+Device&rft.au=Castle%2C+Philip+E%3BAftab%2C+Asma%3BSaint-Jean%2C+Gilbert%3BMendez%2C+Luis&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2006-06-01&rft.volume=44&rft.issue=6&rft.spage=2158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA; Cervix; Human papillomavirus ER - TY - JOUR T1 - Recombinant Human Insulin-Like Growth Factor-I Treatment Inhibits Gluconeogenesis in a Transgenic Mouse Model of Type 2 Diabetes Mellitus AN - 19830971; 6946550 AB - IGF-I and insulin are structurally related polypeptides that mediate a similar pattern of biological effects via receptors that display considerably homology. Administration of recombinant human IGF-I (rhIGF-I) has been proven to improve glucose control and liver and muscle insulin sensitivity in patients with type 2 diabetes mellitus (DM). The effect of rhIGF-I treatment was evaluated in a mouse model of type 2 DM (MKR mouse), which expresses a dominant-negative form of the human IGF-I receptor under the control of the muscle creatine kinase promoter specifically in skeletal muscle. MKR mice have impaired IGF-I and insulin signaling in skeletal muscle, leading to severe insulin resistance in muscle, liver, and fat, developing type 2 DM at 5 wk of age. Six-week-old MKR mice were treated with either saline or rhIGF-I for 3 wk. Blood glucose levels were decreased in response to rhIGF-I treatment in MKR mice. rhIGF-I treatment also increased body weight in MKR with concomitant changes in body composition such as a decrease in fat mass and an increase in lean body mass. Insulin, fatty acid, and triglyceride levels were not affected by rhIGF-I, nor were insulin or glucose tolerance in MKR mice. Hyperinsulinemic-euglycemic clamp analysis demonstrated no improvement in overall insulin sensitivity. Pyruvate and glutamine tolerance tests proved that there was a decrease in the rate of glucose appearance in MKR mice treated with rhIGF-I, suggesting a reduction in the gluconeogenic capacity of liver, kidney, and small intestine. Taken together these results demonstrate that the improvement of the hyperglycemia was achieved by inhibition of gluconeogenesis rather than an improvement in insulin sensitivity. Also, these results suggest that a functional IGF-I receptor in skeletal muscle is required for IGF-I to improve insulin sensitivity in this mouse model of type 2 DM. JF - Endocrinology AU - Pennisi, Patricia AU - Gavrilova, Oksana AU - Setser-Portas, Jennifer AU - Jou, William AU - Santopietro, Stefania AU - Clemmons, David AU - Yakar, Shoshana AU - LeRoith, Derek AD - Diabetes Branch (P.P., J.S.-P., S.S., S.Y., D.L.) and Mouse Metabolism Core Laboratory (O.G., W.J.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 2619 EP - 2630 PB - Endocrine Society, 8401 Connecticut Ave Suite 900 Chevy Chase MD 20815-5817 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 147 IS - 6 SN - 0013-7227, 0013-7227 KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Glutamine KW - Animal models KW - Small intestine KW - Insulin KW - Promoters KW - Creatine kinase KW - Hyperglycemia KW - Pyruvic acid KW - Body weight KW - Triglycerides KW - Gluconeogenesis KW - Skeletal muscle KW - Body composition KW - Lean body mass KW - Insulin-like growth factor I KW - Transgenic mice KW - Insulin-like growth factor I receptors KW - Diabetes mellitus KW - Blood KW - Homology KW - Kidney KW - Liver KW - Fatty acids KW - Glucose tolerance KW - Body fat KW - Signal transduction KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19830971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Recombinant+Human+Insulin-Like+Growth+Factor-I+Treatment+Inhibits+Gluconeogenesis+in+a+Transgenic+Mouse+Model+of+Type+2+Diabetes+Mellitus&rft.au=Pennisi%2C+Patricia%3BGavrilova%2C+Oksana%3BSetser-Portas%2C+Jennifer%3BJou%2C+William%3BSantopietro%2C+Stefania%3BClemmons%2C+David%3BYakar%2C+Shoshana%3BLeRoith%2C+Derek&rft.aulast=Pennisi&rft.aufirst=Patricia&rft.date=2006-06-01&rft.volume=147&rft.issue=6&rft.spage=2619&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Glutamine; Age; Animal models; Small intestine; Insulin; Promoters; Pyruvic acid; Hyperglycemia; Creatine kinase; Body weight; Triglycerides; Gluconeogenesis; Skeletal muscle; Lean body mass; Body composition; Insulin-like growth factor I; Transgenic mice; Insulin-like growth factor I receptors; Diabetes mellitus; Blood; Homology; Fatty acids; Liver; Kidney; Body fat; Glucose tolerance; Signal transduction ER - TY - JOUR T1 - Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations AN - 19820961; 6947664 AB - The major nonspecific porin of Pseudomonas aeruginosa, OprF, produces a large channel yet allows only a slow diffusion of various solutes. Here we provide an explanation of this apparent paradox. We first show, by introduction of tobacco etch virus protease cleavage site in the middle of OprF protein, that most of OprF population folds as a two-domain protein with an N-terminal beta -barrel domain and a C-terminal periplasmic domain rich in alpha -helices. However, sedimentation of unilamellar proteoliposomes through an iso-osmotic gradient showed that only about 5% of the OprF population produced open channels. Gel filtration showed that the open channel conformers tended to occur in oligomeric associations. Because the open channel conformer is likely to fold as a single domain protein with a large beta -barrel, we reasoned that residues near the C terminus may be exposed on cell surface in this conformer. Introduction of a cysteine residue at position 312 produced a functional mutant protein. By using bulky biotinylation reagents on intact cells, we showed that this cysteine residue was not exposed on cell surface in most of the OprF population. However, the minority OprF population that was biotinylated in such experiments was enriched for the conformer with pore-forming activity and had a 10-fold higher pore-forming specific activity than the bulk OprF population. Finally trypsin treatment, which preferentially cleaves the C-terminal domain of the two-domain conformer, did not affect the pore-forming activity of OprF nor did it digest the minority conformer whose residue 312 is exposed on cell surface. JF - Journal of Biological Chemistry AU - Sugawara, Etsuko AU - Nestorovich, Ekaterina M AU - Bezrukov, Sergey M AU - Nikaido, Hiroshi AD - Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 and Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20892-0924 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 16220 EP - 16229 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 24 SN - 0021-9258, 0021-9258 KW - Virology & AIDS Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Trypsin KW - Porins KW - Biotinylation KW - Solutes KW - Filtration KW - Protein folding KW - Cysteine KW - Tobacco KW - Tobacco etch virus KW - Diffusion KW - Proteinase KW - oprF gene KW - Pseudomonas aeruginosa KW - Sedimentation KW - G 07320:Bacterial genetics KW - J 02330:Biochemistry KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19820961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Pseudomonas+aeruginosa+Porin+OprF+Exists+in+Two+Different+Conformations&rft.au=Sugawara%2C+Etsuko%3BNestorovich%2C+Ekaterina+M%3BBezrukov%2C+Sergey+M%3BNikaido%2C+Hiroshi&rft.aulast=Sugawara&rft.aufirst=Etsuko&rft.date=2006-06-01&rft.volume=281&rft.issue=24&rft.spage=16220&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Trypsin; Porins; Biotinylation; Solutes; Filtration; Protein folding; Cysteine; Tobacco; Proteinase; Diffusion; oprF gene; Sedimentation; Tobacco etch virus; Pseudomonas aeruginosa ER - TY - JOUR T1 - Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts AN - 19776359; 6950190 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies were performed to screen for potential toxicities (intrinsic and immunotoxicities). All treatment-related toxicities identified in these repeated-dose toxicology studies have been confined primarily to the sites of injection and seem to be the result of both the delivery method (as they are seen in both control and treated animals) and the intended immune response to the vaccine (as they occur with greater frequency and severity in treated animals). Reactogenicity at the site of injection is generally seen to be reversible as the frequency and severity diminished between doses and between the immediate and recovery termination time points. This observation also correlated with the biodistribution data reported in the companion article (Sheets et al., 2006), in which DNA plasmid vaccine was shown to remain at the site of injection, rather than biodistributing widely, and to clear over time. The results of these safety studies have been submitted to the Food and Drug Administration to support the safety of initiating clinical studies with these and related DNA plasmid vaccines. Thus far, standard repeated-dose toxicology studies have not identified any target organs for toxicity (other than the injection site) for our DNA plasmid vaccines at doses up to 8 mg per immunization, regardless of disease indication (i.e., expressed gene-insert) and despite differences (strengths) in the promoters used to drive this expression. As clinical data accumulate with these products, it will be possible to retrospectively compare the safety profiles of the products in the clinic to the results of the repeated-dose toxicology studies, in order to determine the utility of such toxicology studies for signaling potential immunotoxicities or intrinsic toxicities from DNA vaccines. These data build on the biodistribution studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Andrews, Charla AU - Bailer, Robert AU - Rathmann, John AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 620 EP - 630 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Toxicology Abstracts KW - vaccines KW - Data processing KW - severe acute respiratory syndrome KW - Severe acute respiratory syndrome KW - Ebola virus KW - Toxicity KW - Plasmids KW - Immunization KW - immunization KW - infectious diseases KW - Promoters KW - Immunotoxicity KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Cytokines KW - Immune response KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - Signal transduction KW - V 22360:AIDS and HIV KW - H 14000:Toxicology KW - X 24221:Toxicity testing KW - N 14810:Methods KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicological+Safety+Evaluation+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar+Despite+Differing+Plasmid+Backbones+or+Gene-Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BAndrews%2C+Charla%3BBailer%2C+Robert%3BRathmann%2C+John%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Toxicity; Plasmids; Immunization; Promoters; Immunotoxicity; DNA vaccines; Infectious diseases; Cytokines; Vaccines; Immune response; Signal transduction; Immunoglobulins; immunization; infectious diseases; vaccines; severe acute respiratory syndrome; DNA; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - ADP-ribosyltransferase-specific Modification of Human Neutrophil Peptide-1 AN - 19774457; 6996309 AB - Epithelial cells lining human airways and cells recruited to airways participate in the innate immune response in part by releasing human neutrophil peptides (HNP). Arginine-specific ADP-ribosyltransferases (ART) on the surface of these cells can catalyze the transfer of ADP-ribose from NAD to proteins. We reported that ART1, a mammalian ADP-ribosyltransferase, present in epithelial cells lining the human airway, modified HNP-1, altering its function. ADP-ribosylated HNP-1 was identified in bronchoalveolar lavage fluid (BALF) from patients with asthma, idiopathic pulmonary fibrosis, or a history of smoking (and having two common polymorphic forms of ART1 that differ in activity), but not in normal volunteers or patients with lymphangioleiomyomatosis. Modified HNP-1 was not found in the sputum of cystic fibrosis patients or in leukocyte granules of normal volunteers. The finding of ADP-ribosyl-HNP-1 in BALF but not in leukocyte granules suggests that the modification occurred in the airway. Most of the HNP-1 in the BALF from individuals with a history of smoking was, in fact, mono- or di-ADP-ribosylated. ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24. ADP-ribosylation of HNP-1 by ART1 was substantially greater than that by ART3, ART4, ART5, Pseudomonas aeruginosa exoenzyme S, or cholera toxin A subunit. Mouse ART2, which is an NAD:arginine ADP-ribosyltransferase, was able to modify HNP-1, but to a lesser extent than ART1. Although HNP-1 was not modified to a significant degree by ART5, it inhibited ART5 as well as ART1 activities. Human beta -defensin-1 (HBD1) was a poor transferase substrate. Reduction of the cysteine-rich defensins enhanced their ability to serve as ADP-ribose acceptors. We conclude that ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease. JF - Journal of Biological Chemistry AU - Paone, Gregorino AU - Stevens, Linda A AU - Levine, Rodney L AU - Bourgeois, Christelle AU - Steagall, Wendy K AU - Gochuico, Bernadette R AU - Moss, Joel AD - Pulmonary-Critical Care Medicine Branch and Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17054 EP - 17060 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 25 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Granules KW - Epithelial cells KW - Fibrosis KW - Phospholipase C KW - Smoking KW - Defensins KW - Inflammatory diseases KW - Bronchus KW - Cholera toxin KW - Cigarette smoking KW - Myotubes KW - Escherichia coli KW - Pseudomonas aeruginosa KW - Cystic fibrosis KW - ADP-ribosylation KW - Respiratory tract KW - Exoenzyme S KW - Arginine KW - NAD(P) super(+)-arginine ADP-ribosyltransferase KW - Lung diseases KW - Leukocytes (neutrophilic) KW - Asthma KW - Alveoli KW - NAD KW - Immune response KW - Sputum KW - J 02350:Immunology KW - F 06604:Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19774457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=ADP-ribosyltransferase-specific+Modification+of+Human+Neutrophil+Peptide-1&rft.au=Paone%2C+Gregorino%3BStevens%2C+Linda+A%3BLevine%2C+Rodney+L%3BBourgeois%2C+Christelle%3BSteagall%2C+Wendy+K%3BGochuico%2C+Bernadette+R%3BMoss%2C+Joel&rft.aulast=Paone&rft.aufirst=Gregorino&rft.date=2006-06-01&rft.volume=281&rft.issue=25&rft.spage=17054&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Exoenzyme S; Granules; Epithelial cells; NAD(P) super(+)-arginine ADP-ribosyltransferase; Arginine; Fibrosis; Phospholipase C; Leukocytes (neutrophilic); Lung diseases; Asthma; Alveoli; Smoking; Defensins; NAD; Bronchus; Inflammatory diseases; Cholera toxin; Myotubes; Cigarette smoking; Sputum; Immune response; ADP-ribosylation; Cystic fibrosis; Respiratory tract; Escherichia coli; Pseudomonas aeruginosa ER - TY - JOUR T1 - Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product AN - 19678125; 7420207 AB - Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study. tubA shows potent antiproliferative activity in a panel of human cancer cell lines irrespective of their multidrug resistance properties. It induces apoptosis in cancer cells but not in normal cells and shows significant potential antiangiogenic properties in several @@iin vitro@ assays. It is efficacious in initial animal studies using a hollow fibre assay with 12 different human tumour cell lines. This study suggests that both @@iin vitro@ and preclinical profiles of tubA may translate into clinically useful anticancer properties. JF - Biochemical Journal AU - Kaur, Gurmeet AU - Hollingshead, Melinda AU - Holbeck, Susan AU - Schauer-Vukasinovic, Vesna AU - Camalier, Richard F AU - Doemling, Alexander AU - Agarwal, Seema AD - Developmental Therapeutics Program, DCTD (Division of Cancer Treatment and Diagnosis), NCI (National Cancer Institute), Bethesda, MD 20892, U.S.A., seema.agarwal@yale.edu Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 235 EP - 242 PB - Portland Press Ltd., 59 Portland Place London W1N 3AJ UK, [mailto:sales@portlandpress.co.uk] VL - 396 IS - 2 SN - 0264-6021, 0264-6021 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - antiangiogenic agents KW - Microtubules KW - Apoptosis KW - Myxobacteria KW - natural products KW - Cancer KW - Tumor cell lines KW - Multidrug resistance KW - A 01310:Products of Microorganisms KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19678125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Journal&rft.atitle=Biological+evaluation+of+tubulysin+A%3A+a+potential+anticancer+and+antiangiogenic+natural+product&rft.au=Kaur%2C+Gurmeet%3BHollingshead%2C+Melinda%3BHolbeck%2C+Susan%3BSchauer-Vukasinovic%2C+Vesna%3BCamalier%2C+Richard+F%3BDoemling%2C+Alexander%3BAgarwal%2C+Seema&rft.aulast=Kaur&rft.aufirst=Gurmeet&rft.date=2006-06-01&rft.volume=396&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Biochemical+Journal&rft.issn=02646021&rft_id=info:doi/10.1042%2FBJ20051735.CopyrightTheBiochemicalSociety%2CLondon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Myxobacteria; natural products; Tumor cell lines; Cancer; Apoptosis; Multidrug resistance; Microtubules; antiangiogenic agents DO - http://dx.doi.org/10.1042/BJ20051735.CopyrightTheBiochemicalSociety,London ER - TY - JOUR T1 - Profiling cancer stem cells using protein array technology AN - 19515109; 7211541 AB - Since cancer cells and somatic stem cells share the biological characteristics of self-renewal and proliferation, it has been suggested that the principles of stem cell biology can be applied to improve our understanding of cancer biology. Recent studies have shown that the majority of cancers appear to originate from a small subset of cells that have the ability of self-renewal and to proliferate, namely 'cancer stem cells'. The isolation of cancer stem cells has been demonstrated using cell surface markers in haematopoietic and non-haematopoietic malignancies. Advances in protein array technologies have enabled the use of minuscule amounts of biological materials to profile these cells at the molecular level. Using a combination of protein arrays and cancer stem cell isolation techniques, a higher resolution molecular profiling can be performed, which might improve therapies targeting the cancer stem cells. JF - European Journal of Cancer AU - Nishizuka, S AD - Molecular Translational Technologies, Molecular Therapeutics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, nishizus@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1273 EP - 1282 VL - 42 IS - 9 SN - 0959-8049, 0959-8049 KW - Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Drug discovery KW - Malignancy KW - Stem cells KW - Protein arrays KW - Cell proliferation KW - Cancer KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Cancer&rft.atitle=Profiling+cancer+stem+cells+using+protein+array+technology&rft.au=Nishizuka%2C+S&rft.aulast=Nishizuka&rft.aufirst=S&rft.date=2006-06-01&rft.volume=42&rft.issue=9&rft.spage=1273&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Cancer&rft.issn=09598049&rft_id=info:doi/10.1016%2Fj.ejca.2006.01.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - SuppNotes - Special Issue on Cancer Stem Cells: Opportunities for Novel Diagnostics and Drug Discovery. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Stem cells; Protein arrays; Cell proliferation; Malignancy; Drug discovery; Cell surface DO - http://dx.doi.org/10.1016/j.ejca.2006.01.042 ER - TY - JOUR T1 - Maternal Use of Recreational Drugs and Neuroblastoma in Offspring: A Report from the Children's Oncology Group (United States) AN - 19467726; 7947719 AB - Objective: To evaluate whether maternal use of recreational drugs around conception and pregnancy influences the risk of childhood neuroblastoma. Methods: Self-reported use of recreational drugs from one month prior to pregnancy until diagnosis was assessed among mothers of 538 children with neuroblastoma (diagnosed 1992-1994 and identified through the Children's Cancer Group and Pediatric Oncology Group) and 504 age-matched controls (identified by random-digit dialing). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusting for age at diagnosis and household income. Results: Maternal use of any illicit or recreational drug around pregnancy was associated with an increased risk of neuroblastoma in offspring (OR = 1.82, 95% CI: 1.13, 3.00), particularly use of marijuana in the first trimester of pregnancy (OR = 4.75, 95% CI: 1.55, 16.48). Marijuana use in the month before pregnancy did not increase risk. The effect of gestational marijuana exposure was strongest in subjects diagnosed before age one. Evaluation of recreational drugs other than marijuana was limited by infrequent use, and analyses of drug use by fathers were not carried out due to missing data. Conclusions: Maternal recreational drug use and marijuana use during pregnancy were associated with increased risk of neuroblastoma in offspring. Further examination of these drugs and the risk of childhood cancer is warranted. JF - Cancer Causes & Control AU - Bluhm, Elizabeth C AU - Daniels, Julie AU - Pollock, Brad H AU - Olshan, Andrew F AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Boulevard MSC, 7238, Rockville, MD, 20892-7238, USA, bluhme@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 663 EP - 669 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 5 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Pediatrics KW - Cannabis KW - Progeny KW - Oncology KW - Drug development KW - Children KW - Neuroblastoma KW - Cancer KW - Pregnancy KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Maternal+Use+of+Recreational+Drugs+and+Neuroblastoma+in+Offspring%3A+A+Report+from+the+Children%27s+Oncology+Group+%28United+States%29&rft.au=Bluhm%2C+Elizabeth+C%3BDaniels%2C+Julie%3BPollock%2C+Brad+H%3BOlshan%2C+Andrew+F&rft.aulast=Bluhm&rft.aufirst=Elizabeth&rft.date=2006-06-01&rft.volume=17&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-005-0580-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pediatrics; Cannabis; Drug development; Oncology; Progeny; Children; Cancer; Neuroblastoma; Pregnancy DO - http://dx.doi.org/10.1007/s10552-005-0580-3 ER - TY - JOUR T1 - Isolation of anti-CD22 Fv with high affinity by Fv display on human cells AN - 19454941; 6998808 AB - In vitro antibody affinity maturation has generally been achieved by display of mouse or human antibodies on the surface of microorganisms (phage, bacteria, and yeast). However, problems with protein folding, posttranslational modification, and codon usage still limit the number of improved antibodies that can be obtained. An ideal system would select and improve antibodies in a mammalian cell environment where they are naturally made. Here we show that human embryonic kidney 293T cells that are widely used for transient protein expression can be used for cell surface display of single-chain Fv antibodies for affinity maturation. In a proof-of-concept experiment, cells expressing a rare mutant antibody with higher affinity were enriched 240-fold by a single-pass cell sorting from a large excess of cells expressing WT antibody with a slightly lower affinity. Furthermore, we successfully obtained a highly enriched mutant with increased binding affinity for CD22 after a single selection of a combinatory library randomizing an intrinsic antibody hotspot. Important features are that one display selection cycle requires only 1 week, and transfection of cells in a single 100-mm dish produces 10 super(7) individual clones so that a repertoire of 10 super(9) is feasible under current experimental conditions. JF - Proceedings of the National Academy of Sciences, USA AU - Ho, Mitchell AU - Nagata, Satoshi AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 9637 EP - 9642 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 25 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Phages KW - Cell surface KW - Antibodies KW - CD22 antigen KW - Protein folding KW - Mammalian cells KW - Transfection KW - Hot spots KW - Microorganisms KW - Fv KW - W 30905:Medical Applications KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Isolation+of+anti-CD22+Fv+with+high+affinity+by+Fv+display+on+human+cells&rft.au=Ho%2C+Mitchell%3BNagata%2C+Satoshi%3BPastan%2C+Ira&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2006-06-01&rft.volume=103&rft.issue=25&rft.spage=9637&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Cell surface; CD22 antigen; Antibodies; Mammalian cells; Protein folding; Hot spots; Transfection; Microorganisms; Fv ER - TY - JOUR T1 - A folate receptor-targeted liposomal formulation for paclitaxel AN - 19454128; 6853662 AB - A novel liposomal formulation of paclitaxel targeting the folate receptor (FR) was synthesized and characterized. This formulation was designed to overcome vehicle toxicity associated with the traditional Cremophor EL-based formulation and to provide the added advantages of prolonged systemic circulation time and selective targeting of the FR, which is frequently overexpressed on epithelial cancer cells. The formulation had the composition of dipalmitoyl phosphatidylcholine/dimyristoyl phosphatidylglycerol/monomethoxy- polyethylene glycol (PEG) sub(2000)-distearoyl phosphatidylethanolamine/folate- PEG sub(3350)-distearoyl phosphatidylethanolamine (DPPC/DMPG/mPEG-DSPE/folate-PEG- DSPE) at molar ratios of (85.5:9.5:4.5:0.5) and a drug-to-lipid molar ratio of 1:33. The liposomes were prepared by polycarbonate membrane extrusion. The mean particle size of the liposomes was 97.1 nm and remained stable for at least 72 h at 4 degree C. FR-targeted liposomes of the same lipid composition entrapping calcein were shown to be efficiently taken up by KB oral carcinoma cells, which are highly FR+. FR-targeted liposomes containing paclitaxel showed 3.8-fold greater cytotoxicity compared to non-targeted control liposomes in KB cells. Plasma clearance profiles of paclitaxel in the liposomal formulations were then compared to paclitaxel in Cremophor el formulation. The liposomal formulations showed much longer terminal half-lives (12.33 and 14.23 h for FR-targeted and non-targeted liposomes, respectively) than paclitaxel in Cremophor el (1.78 h). In conclusion, the paclitaxel formulation described in this study has substantial stability and favorable pharmacokinetic properties. The FR-targeted paclitaxel formulation is potentially useful for treatment of FR+ tumors and warrants further investigation. JF - International Journal of Pharmaceutics AU - Wu, Jun AU - Liu, Qing AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NCI Comprehensive Cancer Center, NSF Nanoscale Science and Engineering Center, The Ohio State University, 542 LM Parks Hall, 500 W. 12th Ave., Columbus, OH 43210, United States, lee.1339@osu.edu Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 148 EP - 153 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 316 IS - 1-2 SN - 0378-5173, 0378-5173 KW - Biotechnology and Bioengineering Abstracts KW - Particle size KW - KB cells KW - Calcein KW - phosphatidylglycerol KW - Lecithin KW - Tumors KW - Toxicity KW - Liposomes KW - Pharmacokinetics KW - Cytotoxicity KW - oral carcinoma KW - Paclitaxel KW - Lipid composition KW - phosphatidylethanolamine KW - Folic acid KW - Polyethylene glycol KW - polycarbonate KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Pharmaceutics&rft.atitle=A+folate+receptor-targeted+liposomal+formulation+for+paclitaxel&rft.au=Wu%2C+Jun%3BLiu%2C+Qing%3BLee%2C+Robert+J&rft.aulast=Wu&rft.aufirst=Jun&rft.date=2006-06-01&rft.volume=316&rft.issue=1-2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2006.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Paclitaxel; Liposomes; Folic acid; phosphatidylethanolamine; Toxicity; Lecithin; Polyethylene glycol; Particle size; phosphatidylglycerol; polycarbonate; Calcein; Tumors; Pharmacokinetics; Cytotoxicity; Lipid composition; KB cells; oral carcinoma DO - http://dx.doi.org/10.1016/j.ijpharm.2006.02.027 ER - TY - JOUR T1 - A permissive secondary structure-guided superposition tool for clustering of protein fragments toward protein structure prediction via fragment assembly AN - 19450696; 6945239 AB - MOTIVATION: Secondary-Structure Guided Superposition tool (SSGS) is a permissive secondary structure-based algorithm for matching of protein structures and in particular their fragments. The algorithm was developed towards protein structure prediction via fragment assembly. RESULTS: In a fragment-based structural prediction scheme, a protein sequence is cut into building blocks (BBs). The BBs are assembled to predict their relative 3D arrangement. Finally, the assemblies are refined. To implement this prediction scheme, a clustered structural library representing sequence patterns for protein fragments is essential. To create a library, BBs generated by cutting proteins from the PDB are compared and structurally similar BBs are clustered. To allow structural comparison and clustering of the BBs, which are often relatively short with flexible loops, we have devised SSGS. SSGS maintains high similarity between cluster members and is highly efficient. When it comes to comparing BBs for clustering purposes, the algorithm obtains better results than other, non-secondary structure guided protein superimposition algorithms. AVAILABILITY: SSGS is available for download at http://www.cs.tau.ac.il/~wainreb CONTACT: ruthncifcrf.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Wainreb, Gilad AU - Haspel, Nurit AU - Wolfson, Haim J AU - Nussinov, Ruth AD - Sackler Institute of Molecular Medicine, Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv 69978, Israel. School of Computer Science, Faculty of Exact Sciences, Tel Aviv University Tel Aviv 69978, Israel. Basic Research Program, SAIC-Frederick, Inc., Laboratory of Experimental and Computational Biology NCI-Frederick, Building 469, Rm 151, Frederick, MD 21702, USA Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 1343 EP - 1352 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 11 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Algorithms KW - Bioinformatics KW - Amino acid sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19450696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+permissive+secondary+structure-guided+superposition+tool+for+clustering+of+protein+fragments+toward+protein+structure+prediction+via+fragment+assembly&rft.au=Wainreb%2C+Gilad%3BHaspel%2C+Nurit%3BWolfson%2C+Haim+J%3BNussinov%2C+Ruth&rft.aulast=Wainreb&rft.aufirst=Gilad&rft.date=2006-06-01&rft.volume=22&rft.issue=11&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Algorithms; Protein structure; Amino acid sequence; Bioinformatics ER - TY - JOUR T1 - Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties AN - 19449021; 6904884 AB - Scientists and entrepreneurs who contemplate developing nanomedicine products face several unique challenges in addition to many of the traditional hurdles of product development. In this review we analyze the major physicochemical, biologic and functional characteristics of several nanomedicine products on the market and explore the question of what made them unique. What made them successful? We also focus on the regulatory challenges faced by nanomedicine product developers. Based on these analyses, we propose the factors that are most likely to contribute to the success of nanomedicine products. JF - Nanomedicine: Nanotechnology, Biology and Medicine AU - Nijhara, Ruchika AU - Balakrishnan, Krishna AD - University of Maryland, Office of Research and Development, Baltimore, MD, United States, balki@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 127 EP - 136 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 2 IS - 2 SN - 1549-9634, 1549-9634 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19449021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine%3A+Nanotechnology%2C+Biology+and+Medicine&rft.atitle=Bringing+nanomedicines+to+market%3A+regulatory+challenges%2C+opportunities%2C+and+uncertainties&rft.au=Nijhara%2C+Ruchika%3BBalakrishnan%2C+Krishna&rft.aulast=Nijhara&rft.aufirst=Ruchika&rft.date=2006-06-01&rft.volume=2&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Nanomedicine%3A+Nanotechnology%2C+Biology+and+Medicine&rft.issn=15499634&rft_id=info:doi/10.1016%2Fj.nano.2006.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews; nanotechnology DO - http://dx.doi.org/10.1016/j.nano.2006.04.005 ER - TY - JOUR T1 - Analysis of internal loops within the RNA secondary structure in almost quadratic time AN - 19447367; 6945236 AB - MOTIVATION: Evaluating all possible internal loops is one of the key steps in predicting the optimal secondary structure of an RNA molecule. The best algorithm available runs in time O(L super(3)), L is the length of the RNA. RESULTS: We propose a new algorithm for evaluating internal loops, its run-time is O(M super(*)log super(2)L), M < L super(2) is a number of possible nucleotide pairings. We created a software tool Afold which predicts the optimal secondary structure of RNA molecules of lengths up to 28 000 nt, using a computer with 2 Gb RAM. We also propose algorithms constructing sets of conditionally optimal multi-branch loop free (MLF) structures, e.g. the set that for every possible pairing (x, y) contains an optimal MLF structure in which nucleotides x and y form a pair. All the algorithms have run-time O(M super(*)log super(2)L). AVAILABILITY: Executables of Afold software tool, precompiled for Linux and Windows, are available at ftp://ftp.ncbi.nlm.nih.gov/pub/ogurtsov/Afold. CONTACT: MRoytbergmpb.psn.ru Supplementary information: ftp://ftp.ncbi.nlm.nih.gov/pub/ogurtsov/Afold JF - Bioinformatics AU - Ogurtsov, Aleksey Y AU - Shabalina, Svetlana A AU - Kondrashov, Alexey S AU - Roytberg, Mikhail A AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA. Institute of Mathematical Problems in Biology, Russian Academy of Science Pushchino, Moscow Region, 142290, Russia Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 1317 EP - 1324 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 11 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein structure KW - Computer programs KW - software KW - RNA KW - Computers KW - Secondary structure KW - Algorithms KW - Bioinformatics KW - Nucleotides KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19447367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Analysis+of+internal+loops+within+the+RNA+secondary+structure+in+almost+quadratic+time&rft.au=Ogurtsov%2C+Aleksey+Y%3BShabalina%2C+Svetlana+A%3BKondrashov%2C+Alexey+S%3BRoytberg%2C+Mikhail+A&rft.aulast=Ogurtsov&rft.aufirst=Aleksey&rft.date=2006-06-01&rft.volume=22&rft.issue=11&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; Computer programs; software; RNA; Computers; Secondary structure; Algorithms; Bioinformatics; Nucleotides ER - TY - JOUR T1 - Modifiable Environmental and Behavioral Determinants of Overweight among Children and Adolescents: Report of a Workshop AN - 19366975; 7129867 AB - The number of children at risk for overweight and the number of overweight children are increasing and have become a serious public health concern. Interventions that could be applied at the population level have not been proven effective. The development of effective strategies is thought to be hampered by the lack of understanding of which behavioral and environmental factors need to be modified. On June 14 and 15, 2004, the NIH held a meeting of experts to discuss the issue of modifiable determinants of obesity in children and adolescents. Included were presentations on interventions among children that have been proven effective, dietary and physical activity behavioral determinants, physical, social, and family environmental determinants, and the quality of measures of determinants and correlates of overweight. JF - Obesity Research AU - Johnson-Taylor, Wendy L AU - Everhart, James E AD - Division of Nutrition Research Coordination, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Clinical Trials Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 929 EP - 966 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Issues KW - Adolescence KW - Strategy KW - Family KW - Exercise KW - Children KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Modifiable+Environmental+and+Behavioral+Determinants+of+Overweight+among+Children+and+Adolescents%3A+Report+of+a+Workshop&rft.au=Johnson-Taylor%2C+Wendy+L%3BEverhart%2C+James+E&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2006-06-01&rft.volume=14&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Issues; Adolescence; Strategy; Family; Exercise; Children; Public health ER - TY - JOUR T1 - Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice AN - 19285844; 7022790 AB - The metabolism and disposition of super(14)C-labelled 2,2',4,4',5-pentabromodiphenyl ether (BDE99) were studied in F344 rats and B6C3F1 mice. Approximately 85% of a 1 mu mol kg super(-1) oral dose was absorbed by male rats and mice. Within 24 h following oral doses ranging from 0.1 to 1000 mu mol kg super(-1) to rats, 39-47% of the dose was excreted in the faeces (including 16% unabsorbed), up to 2% was excreted in the urine, and 34-38% remained in the tissues, mostly in adipose tissue. Mice excreted more in the urine and less in the faeces than rats. Tissue accumulation was observed following repeated dosing to rats. Two dihydrohydroxy-S-glutathionyl and two S-glutathionyl conjugates of BDE99, 2,4,5-tribromophenol glucuronide, two mono-hydroxylated BDE99 glucuronides, and three mono-hydroxylated tetrabromodiphenyl ether glucuronides were identified in male rat bile. 2,4,5-Tribromophenol and its glucuronide and sulfate conjugates, were identified in male rat urine. 2,4,5-Tribromophenol, one mono-hydroxylated tetrabromodiphenyl ether, and two mono-hydroxylated BDE99 were characterized in male rat faeces. BDE99 undergoes more extensive metabolism than does BDE47. Half of the absorbed oral dose in male rats was excreted in 10 days mostly as metabolites derived from arene oxide intermediates. JF - Xenobiotica AU - Chen, L-J AU - Lebetkin, E H AU - Sanders, J M AU - Burka, L T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 515 EP - 534 VL - 36 IS - 6 SN - 0049-8254, 0049-8254 KW - mice KW - rats KW - Toxicology Abstracts KW - Urine KW - Bile KW - Adipose tissue KW - oxides KW - Disposition KW - Metabolites KW - Ethers KW - Feces KW - Metabolism KW - Sulfate KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19285844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Metabolism+and+disposition+of+2%2C2%27%2C4%2C4%27%2C5-pentabromodiphenyl+ether+%28BDE99%29+following+a+single+or+repeated+administration+to+rats+or+mice&rft.au=Chen%2C+L-J%3BLebetkin%2C+E+H%3BSanders%2C+J+M%3BBurka%2C+L+T&rft.aulast=Chen&rft.aufirst=L-J&rft.date=2006-06-01&rft.volume=36&rft.issue=6&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250600674477 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Urine; Bile; oxides; Adipose tissue; Metabolites; Disposition; Ethers; Feces; Metabolism; Sulfate DO - http://dx.doi.org/10.1080/00498250600674477 ER - TY - JOUR T1 - Environmental Exposure Assessment of Pesticides in Farmworker Homes AN - 19277662; 7018336 AB - Farmworkers and their families are exposed to pesticides both at work and in their homes. Environmental exposure assessment provides a means to evaluate pesticides in the environment and human contact with these chemicals through identification of sources and routes of exposure. To date, a variety of methods have been used to assess pesticide exposure among farmworker families, mostly focusing on dust and handwipe samples. While many of the methods are similar, differences in the collection, chemical analysis, and statistical analysis, can limit the comparability of results from farmworker studies. This mini-monograph discusses the strategies used to assess pesticide exposures, presents limitations in the available data for farmworkers, and suggests research needs for future studies of pesticide exposure among farmworker families. JF - Environmental Health Perspectives AU - Hoppin, JA AU - Adgate, J L AU - Eberhart, M AU - Nishioka, M AU - Ryan, P B AD - NIEHS, Epidemiology Branch, PO Box 12233, Research Triangle Park, NC 27709, USA, hoppin1@niehs.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 929 EP - 935 VL - 114 IS - 6 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts; Risk Abstracts KW - Pesticides KW - Residential areas KW - Agrochemicals KW - Chemical analysis KW - Dust KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19277662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Environmental+Exposure+Assessment+of+Pesticides+in+Farmworker+Homes&rft.au=Hoppin%2C+JA%3BAdgate%2C+J+L%3BEberhart%2C+M%3BNishioka%2C+M%3BRyan%2C+P+B&rft.aulast=Hoppin&rft.aufirst=JA&rft.date=2006-06-01&rft.volume=114&rft.issue=6&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Pesticides; Residential areas; Chemical analysis; Agrochemicals; Occupational exposure; Dust DO - http://dx.doi.org/10.1289/ehp.8530 ER - TY - JOUR T1 - The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1 beta production AN - 17266394; 6998893 AB - Familial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder with high carrier frequencies in the Middle East. Pyrin, the protein mutated in FMF, regulates caspase-1 activation and consequently IL-1 beta production through cognate interaction of its N-terminal PYRIN motif with the ASC adaptor protein. However, the preponderance of mutations reside in pyrin's C-terminal B30.2 domain. Here we demonstrate direct interaction of this domain with caspase-1. In lysates from cells not expressing ASC, reciprocal GST pull-downs demonstrated the interaction of pyrin with the p20 and p10 catalytic subunits of caspase-1. Coimmunoprecipitations of pyrin and caspase-1 from THP-1 human monocytic cells were consistent with the interaction of endogenous proteins. The C-terminal B30.2 domain of pyrin is necessary and sufficient for the interaction, and binding was reduced by FMF-associated B30.2 mutations. Full-length pyrin attenuated IL-1 beta production in cells transfected with a caspase-1/IL-1 beta construct, an effect diminished by FMF-associated B30.2 mutations and in B30.2 deletion mutants. Modeling of the crystal structure of caspase-1 with the deduced structure of the pyrin B30.2 domain corroborated both the interaction and the importance of M694V and M680I pyrin mutations. Consistent with a net inhibitory effect of pyrin on IL-1 beta activation, small interfering RNA (siRNA)-mediated pyrin knockdown in THP-1 cells augmented IL-1 beta production in response to bacterial LPS. Moreover, the IL-1 receptor antagonist anakinra suppressed acute-phase proteins in a patient with FMF and amyloidosis. Our data support a direct, ASC-independent effect of pyrin on IL-1 beta activation and suggest heightened IL-1 responsiveness as one factor selecting for pyrin mutations. JF - Proceedings of the National Academy of Sciences, USA AU - Chae, Jae Jin AU - Wood, Geryl AU - Masters, Seth L AU - Richard, Katharina AU - Park, Grace AU - Smith, Brian J AU - Kastner, Daniel L AD - Genetics and Genomics Branch and Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 9982 EP - 9987 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 26 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Deletion mutant KW - Data processing KW - Interleukin 1 KW - Catalytic subunits KW - Interleukin 1 receptor antagonist KW - Pyrin protein KW - Acute phase substances KW - Familial Mediterranean fever KW - Amyloidosis KW - adaptor proteins KW - pyrin KW - siRNA KW - Crystal structure KW - Lipopolysaccharides KW - Caspase-1 KW - Monocytes KW - Mutation KW - J 02310:Genetics & Taxonomy KW - F 06608:Autoimmunity and immune tolerance cellular mechanism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17266394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=The+B30.2+domain+of+pyrin%2C+the+familial+Mediterranean+fever+protein%2C+interacts+directly+with+caspase-1+to+modulate+IL-1+beta+production&rft.au=Chae%2C+Jae+Jin%3BWood%2C+Geryl%3BMasters%2C+Seth+L%3BRichard%2C+Katharina%3BPark%2C+Grace%3BSmith%2C+Brian+J%3BKastner%2C+Daniel+L&rft.aulast=Chae&rft.aufirst=Jae&rft.date=2006-06-01&rft.volume=103&rft.issue=26&rft.spage=9982&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Deletion mutant; Interleukin 1; Catalytic subunits; Interleukin 1 receptor antagonist; Pyrin protein; Familial Mediterranean fever; Acute phase substances; adaptor proteins; Amyloidosis; pyrin; siRNA; Crystal structure; Lipopolysaccharides; Caspase-1; Monocytes; Mutation ER - TY - JOUR T1 - Parent involvement in novice teen driving: a review of the literature AN - 17264718; 6995853 AB - Motor vehicle crashes remain elevated among novice teen drivers for at least several years after licensure. Licensing policies and driver education are the two primary countermeasures employed to decrease young driver crash risks. Graduated driver licensing policies have proved to be effective in reducing crash rates where evaluated. Driver education is an essential part of teaching teens the rules of the road and operating a vehicle, but requires few hours of professional driver training, relying mainly on parents to provide most of the supervised practice driving teens obtain before independent driving licensure. The few studies that have been conducted to increase parent supervised practice driving have not shown positive results. Moreover, it is unclear that increases in practice would improve independent driving safety. Recent research has shown that parent management of the early independent driving experience of novice teens improves safety outcomes, and other research has shown that it is possible to increase parent management practices. This paper provides a review of the literature on parent involvement in supervised practice and independent driving, and efforts to increase parental management. JF - Injury Prevention AU - Simons-Morton, B AU - Ouimet, M C AD - National Institute of Child Health and Human Development, Bethesda, MD, USA Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - i30 EP - i37 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 12 SN - 1353-8047, 1353-8047 KW - parent involvement KW - Health & Safety Science Abstracts; Risk Abstracts KW - Education KW - Accidents KW - Government programs KW - Training KW - Reviews KW - Motor vehicles KW - Licensing KW - State programs KW - prevention KW - Human factors KW - Risk reduction KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17264718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Parent+involvement+in+novice+teen+driving%3A+a+review+of+the+literature&rft.au=Simons-Morton%2C+B%3BOuimet%2C+M+C&rft.aulast=Simons-Morton&rft.aufirst=B&rft.date=2006-06-01&rft.volume=12&rft.issue=&rft.spage=i30&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Accidents; Education; Training; Government programs; Motor vehicles; Reviews; State programs; Licensing; prevention; Risk reduction; Human factors ER - TY - JOUR T1 - Genetic Requirements for Growth of Escherichia coli K12 on Methyl- alpha -D-glucopyranoside and the Five alpha -D-Glucosyl-D-fructose Isomers of Sucrose AN - 17258135; 6996402 AB - Strains of Escherichia coli K12, including MG-1655, accumulate methyl- alpha -D-glucopyranoside via the phosphoenolpyruvate-dependent glucose:phosphotransferase system (IICB super(Glc)/IIA super(Glc)). High concentrations of intracellular methyl- alpha -D-glucopyranoside 6-phosphate are toxic, and cell growth is prevented. However, transformation of E. coli MG-1655 with a plasmid (pAP1) encoding the gene aglB from Klebsiella pneumoniae resulted in excellent growth of the transformant MG-1655 (pAP1) on the glucose analog. AglB is an unusual NAD super(+)/Mn super(2+)-dependent phospho- alpha -glucosidase that promotes growth of MG-1655 (pAP1) by catalyzing the in vivo hydrolysis of methyl- alpha -D-glucopyranoside 6-phosphate to yield glucose 6-phosphate and methanol. When transformed with plasmid pAP2 encoding the K. pneumoniae genes aglB and aglA (an alpha -glucoside-specific transporter AglA (IICB super(Agl))), strain MG-1655 (pAP2) metabolized a variety of other alpha -linked glucosides, including maltitol, isomaltose, and the following five isomers of sucrose: trehalulose alpha (1 arrow right 1), turanose alpha (1 arrow right 3), maltulose alpha (1 arrow right 4), leucrose alpha (1 arrow right 5), and palatinose alpha (1 arrow right 6). Remarkably, MG-1655 (pAP2) failed to metabolize sucrose alpha (1 arrow right 2). The E. coli K12 strain ZSC112L (ptsG::cat manXYZ nagE glk lac) can neither grow on glucose nor transport methyl- alpha -D-glucopyranoside. However, when transformed with pTSGH11 (encoding ptsG) or pAP2, this organism provided membranes that contained either the PtsG or AglA transporters, respectively. In vitro complementation of transporter-specific membranes with purified general phosphotransferase components showed that although PtsG and AglA recognized glucose and methyl- alpha -D-glucopyranoside, only AglA accepted other alpha -D-glucosides as substrates. Complementation experiments also revealed that IIA super(Glc) was required for functional activity of both PtsG and AglA transporters. We conclude that AglA, AglB, and IIA super(Glc) are necessary and sufficient for growth of E. coli K12 on methyl- alpha -D-glucoside and related alpha -D-glucopyranosides. JF - Journal of Biological Chemistry AU - Pikis, Andreas AU - Hess, Sonja AU - Arnold, Ingrid AU - Erni, Bernhard AU - Thompson, John AD - Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, NIDCR, and the Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 and the Departement fuer Chemie und Biochemie, Universitaet Bern, CH-3012 Bern, Switzerland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 17900 EP - 17908 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 26 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Transformation KW - Methanol KW - phosphotransferase KW - Plasmids KW - glucosides KW - Hydrolysis KW - Isomers KW - Growth KW - Complementation KW - Sucrose KW - Glucose transport KW - Escherichia coli KW - Klebsiella pneumoniae KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17258135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Genetic+Requirements+for+Growth+of+Escherichia+coli+K12+on+Methyl-+alpha+-D-glucopyranoside+and+the+Five+alpha+-D-Glucosyl-D-fructose+Isomers+of+Sucrose&rft.au=Pikis%2C+Andreas%3BHess%2C+Sonja%3BArnold%2C+Ingrid%3BErni%2C+Bernhard%3BThompson%2C+John&rft.aulast=Pikis&rft.aufirst=Andreas&rft.date=2006-06-01&rft.volume=281&rft.issue=26&rft.spage=17900&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Growth; Complementation; Sucrose; Methanol; Glucose transport; phosphotransferase; glucosides; Plasmids; Hydrolysis; Isomers; Escherichia coli; Klebsiella pneumoniae ER - TY - JOUR T1 - Ethanol Inhibits Clearance of Brain Serotonin by a Serotonin Transporter-Independent Mechanism AN - 17253989; 6997377 AB - Brain serotonin (5-HT) modulates the neural and behavioral effects of ethanol in a manner that remains poorly understood. Here we show that treatment with physiologically relevant (i.e., moderately intoxicating) doses of ethanol inhibits clearance of 5-HT from extracellular fluid in the mouse hippocampus. This finding demonstrates, in vivo, a key molecular mechanism by which ethanol modulates serotonergic neurotransmission. The 5-HT transporter (5-HTT) is the principle means of 5-HT reuptake in the brain and an obvious candidate mechanism for the effect of ethanol to inhibit 5-HT clearance. However, our second major finding was that genetic inactivation of the 5-HTT in a knock-out mouse not only failed to prevent ethanol-induced inhibition of 5-HT clearance, but actually potentiated this effect. Ethanol-induced inhibition of 5-HT clearance was also potentiated in nonmutant mice by cotreatment with a 5-HTT antagonist. Providing a link with potential behavioral manifestations of this neural phenotype, 5-HTT knock-out mice also exhibited exaggerated sensitivity to behavioral intoxication, as assayed by the sedative/hypnotic effects of ethanol. This clearly demonstrates that the 5-HTT is not necessary for the neural and behavioral effects of ethanol observed herein and that genetic or pharmacological inactivation of the 5-HTT unmasks involvement of other principle mechanisms. These data are intriguing given growing evidence implicating the 5-HTT in the pathophysiology and treatment of alcoholism and neuropsychiatric conditions frequently comorbid with alcoholism, such as depression. The present findings provide new insights into the actions of ethanol on brain function and behavior. JF - Journal of Neuroscience AU - Daws, Lynette C AU - Montanez, Sylvia AU - Munn, Jaclyn L AU - Owens, WAnthony AU - Baganz, Nicole L AU - Boyce-Rustay, Janel M AU - Millstein, Rachel A AU - Wiedholz, Lisa M AU - Murphy, Dennis L AU - Holmes, Andrew AD - Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, and Laboratory of Clinical Science, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 6431 EP - 6438 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 24 SN - 0270-6474, 0270-6474 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Intoxication KW - Molecular modelling KW - Depression KW - Hippocampus KW - Brain KW - Hypnotics KW - Drug abuse KW - Serotonin KW - Sedatives KW - Neurotransmission KW - Alcoholism KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11106:Neurobiology of drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17253989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Ethanol+Inhibits+Clearance+of+Brain+Serotonin+by+a+Serotonin+Transporter-Independent+Mechanism&rft.au=Daws%2C+Lynette+C%3BMontanez%2C+Sylvia%3BMunn%2C+Jaclyn+L%3BOwens%2C+WAnthony%3BBaganz%2C+Nicole+L%3BBoyce-Rustay%2C+Janel+M%3BMillstein%2C+Rachel+A%3BWiedholz%2C+Lisa+M%3BMurphy%2C+Dennis+L%3BHolmes%2C+Andrew&rft.aulast=Daws&rft.aufirst=Lynette&rft.date=2006-06-01&rft.volume=26&rft.issue=24&rft.spage=6431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Intoxication; Molecular modelling; Sedatives; Depression; Neurotransmission; Hippocampus; Alcoholism; Hypnotics; Brain; Drug abuse; Serotonin; Ethanol ER - TY - JOUR T1 - Orthopedic Complications of Overweight in Children and Adolescents AN - 17253822; 6998453 AB - OBJECTIVE. Few studies have quantified the prevalence of weight-related orthopedic conditions in otherwise healthy overweight children. The goal of the present investigation was to describe the musculoskeletal consequences of pediatric overweight in a large pediatric cohort of children that included severely overweight children. METHODS. Medical charts from 227 overweight and 128 nonoverweight children and adolescents who were enrolled in pediatric clinical studies at the National Institutes of Health from 1996 to 2004 were reviewed to record pertinent orthopedic medical history and musculoskeletal complaints. Questionnaire data from 183 enrollees (146 overweight) documented difficulties with mobility. In 250, lower extremity alignment was determined by bilateral metaphyseal-diaphyseal and anatomic tibiofemoral angle measurements made from whole-body dual-energy x-ray absorptiometry scans. RESULTS. Compared with nonoverweight children, overweight children reported a greater prevalence of fractures and musculoskeletal discomfort. The most common self-reported joint complaint among those who were questioned directly was knee pain (21.4% overweight vs 16.7% nonoverweight). Overweight children reported greater impairment in mobility than did nonoverweight children (mobility score: 17.0 plus or minus 6.8 vs 11.6 plus or minus 2.8). Both metaphyseal-diaphyseal and anatomic tibiofemoral angle measurements showed greater malalignment in overweight compared with nonoverweight children. CONCLUSIONS. Reported fractures, musculoskeletal discomfort, impaired mobility, and lower extremity malalignment are more prevalent in overweight than nonoverweight children and adolescents. Because they affect the likelihood that children will engage in physical activity, orthopedic difficulties may be part of the cycle that perpetuates the accumulation of excess weight in children. JF - Pediatrics AU - Taylor, Erica D AU - Theim, Kelly R AU - Mirch, Margaret C AU - Ghorbani, Samareh AU - Tanofsky-Kraff, Marian AU - Adler-Wailes, Diane C AU - Brady, Sheila AU - Reynolds, James C AU - Calis, Karim A AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 2167 EP - 2174 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 6 SN - 0031-4005, 0031-4005 KW - Physical Education Index; Risk Abstracts KW - Measurement KW - Knees KW - pain KW - Health (history) KW - Legs KW - Pain KW - extremities KW - Weight KW - physical activity KW - Adolescents KW - Obesity KW - Complications KW - Pediatrics KW - Adolescence KW - Orthopedics KW - Fractures KW - Surveys KW - Exercise KW - Children KW - Movement KW - musculoskeletal system KW - Joints KW - X-Ray KW - Reviews KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17253822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Orthopedic+Complications+of+Overweight+in+Children+and+Adolescents&rft.au=Taylor%2C+Erica+D%3BTheim%2C+Kelly+R%3BMirch%2C+Margaret+C%3BGhorbani%2C+Samareh%3BTanofsky-Kraff%2C+Marian%3BAdler-Wailes%2C+Diane+C%3BBrady%2C+Sheila%3BReynolds%2C+James+C%3BCalis%2C+Karim+A%3BYanovski%2C+Jack+A&rft.aulast=Taylor&rft.aufirst=Erica&rft.date=2006-06-01&rft.volume=117&rft.issue=6&rft.spage=2167&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Measurement; Pediatrics; Adolescence; Orthopedics; Fractures; Knees; Health (history); Surveys; Pain; Legs; Exercise; Children; Movement; Joints; X-Ray; Weight; Complications; Reviews; pain; physical activity; extremities; Adolescents; musculoskeletal system ER - TY - JOUR T1 - Gangliosides Are Essential for Bovine Adeno-Associated Virus Entry AN - 17242246; 6948768 AB - Recombinant adeno-associated viruses (AAV) are promising gene therapy vectors. We have recently identified a bovine adeno-associated virus (BAAV) that demonstrates unique tropism and transduction activity compared to primate AAVs. To better understand the entry pathway and cell tropism of BAAV, we have characterized the initial cell surface interactions required for transduction with BAAV vectors. Like a number of AAVs, BAAV requires cell surface sialic acid groups for transduction and virus attachment. However, glycosphingolipids (GSLs), not cell surface proteins, were required for vector entry and transduction. Incorporation of gangliosides, ceramide-based glycolipids containing one or more sialic acid groups, into the cytoplasmic cell membranes of GSL-depleted COS cells partially reconstituted BAAV transduction. The dependency of BAAV on gangliosides for transduction was further confirmed by studies with C6 cells, a rat glioma cell line that is deficient in the synthesis of complex gangliosides. C6 cells were resistant to transduction by BAAV. Addition of gangliosides to C6 cells prior to transduction rendered the cells susceptible to transduction by BAAV. Therefore, gangliosides are a likely receptor for BAAV. JF - Journal of Virology AU - Schmidt, Michael AU - Chiorini, John A AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 5516 EP - 5522 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 11 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Cell surface KW - Gene therapy KW - Glycosphingolipids KW - Tropism KW - Bovine adeno-associated virus KW - Gangliosides KW - Expression vectors KW - Glycolipids KW - Cell membranes KW - Glioma cells KW - Sialic acids KW - W3 33181:Gene therapy vectors KW - W 30965:Miscellaneous, Reviews KW - V 22042:Adsorption, penetration & uncoating UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17242246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Gangliosides+Are+Essential+for+Bovine+Adeno-Associated+Virus+Entry&rft.au=Schmidt%2C+Michael%3BChiorini%2C+John+A&rft.aulast=Schmidt&rft.aufirst=Michael&rft.date=2006-06-01&rft.volume=80&rft.issue=11&rft.spage=5516&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bovine adeno-associated virus; Gangliosides; Cell surface; Sialic acids; Tropism; Cell membranes; Glioma cells; Glycolipids; Expression vectors; Gene therapy; Glycosphingolipids ER - TY - JOUR T1 - Detection of Anthrax Toxin in the Serum of Animals Infected with Bacillus anthracis by Using Engineered Immunoassays AN - 17239884; 6945919 AB - Several strategies that target anthrax toxin are being developed as therapies for infection by Bacillus anthracis. Although the action of the tripartite anthrax toxin has been extensively studied in vitro, relatively little is known about the presence of toxins during an infection in vivo. We developed a series of sensitive sandwich enzyme-linked immunosorbent assays (ELISAs) for detection of both the protective antigen (PA) and lethal factor (LF) components of the anthrax exotoxin in serum. The assays utilize as capture agents an engineered high-affinity antibody to PA, a soluble form of the extracellular domain of the anthrax toxin receptor (ANTXR2/CMG2), or PA itself. Sandwich immunoassays were used to detect and quantify PA and LF in animals infected with the Ames or Vollum strains of anthrax spores. PA and LF were detected before and after signs of toxemia were observed, with increasing levels reported in the late stages of the infection. These results represent the detection of free PA and LF by ELISA in the systemic circulation of two animal models exposed to either of the two fully virulent strains of anthrax. Simple anthrax toxin detection ELISAs could prove useful in the evaluation of potential therapies and possibly as a clinical diagnostic to complement other strategies for the rapid identification of B. anthracis infection. JF - Clinical and Vaccine Immunology AU - Mabry, Robert AU - Brasky, Kathleen AU - Geiger, Robert AU - Carrion, Ricardo Jr AU - Hubbard, Gene B AU - Leppla, Stephen AU - Patterson, Jean L AU - Georgiou, George AU - Iverson, B L AD - Institute for Cellular and Molecular Biology, University of Texas at Austin, Texas. Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas. Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas. Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Department of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, Austin, Texas. Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 671 EP - 677 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 6 SN - 1556-6811, 1556-6811 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Lethal factor KW - protective antigen KW - Complement KW - Animal models KW - Bacillus anthracis KW - Infection KW - Toxemia KW - Exotoxins KW - Toxins KW - Antibodies KW - Anthrax KW - Vaccines KW - Spores KW - Immunoassays KW - X 24370:Natural Toxins KW - F 06704:Immunoassays KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17239884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Detection+of+Anthrax+Toxin+in+the+Serum+of+Animals+Infected+with+Bacillus+anthracis+by+Using+Engineered+Immunoassays&rft.au=Mabry%2C+Robert%3BBrasky%2C+Kathleen%3BGeiger%2C+Robert%3BCarrion%2C+Ricardo+Jr%3BHubbard%2C+Gene+B%3BLeppla%2C+Stephen%3BPatterson%2C+Jean+L%3BGeorgiou%2C+George%3BIverson%2C+B+L&rft.aulast=Mabry&rft.aufirst=Robert&rft.date=2006-06-01&rft.volume=13&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Lethal factor; Complement; protective antigen; Animal models; Infection; Toxins; Exotoxins; Toxemia; Antibodies; Anthrax; Vaccines; Spores; Immunoassays; Bacillus anthracis ER - TY - JOUR T1 - Pseudomonas aeruginosa Porin OprF: Properties Of The Channel AN - 17238179; 6947665 AB - Using ion channel reconstitution in planar lipid bilayers, we examined the channel-forming activity of subfractions of Pseudomonas aeruginosa OprF, which was shown to exist in two different conformations: a minority single domain conformer and a majority two-domain conformer (Sugawara, E., Nestorovich, E. M., Bezrukov, S. M., and Nikaido, H. (2006) J. Biol. Chem. 281, 16220-16229). With the fraction depleted for the single domain conformer, we were unable to detect formation of any channels with well defined conductance levels. With the unfractionated OprF, we saw only rare channel formation. However, with the single domain-enriched fraction of OprF, we observed regular insertion of channels with highly reproducible conductances. Single OprF channels demonstrate rich kinetic behavior exhibiting spontaneous transitions between several subconformations that differ in ionic conductance and radius measured in polymer exclusion experiments. Although we showed that the effective radius of the most conductive conformation exceeds that of the general outer membrane porin of Escherichia coli, OmpF, we also found that a single OprF channel mainly exists in weakly conductive subconformations and switches to the fully open state for a short time only. Therefore, the low permeability of OprF reported earlier may be due to two factors: mainly to the paucity of the single domain conformer in the OprF population and secondly to the predominance of weakly conductive subconformations within the single domain conformer. JF - Journal of Biological Chemistry AU - Nestorovich, Ekaterina M AU - Sugawara, Etsuko AU - Nikaido, Hiroshi AU - Bezrukov, Sergey M AD - Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20892-0924 and the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 16230 EP - 16237 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 24 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Permeability KW - Lipid bilayers KW - Conductance KW - Porins KW - Kinetics KW - Ion channels KW - Outer membranes KW - Escherichia coli KW - Pseudomonas aeruginosa KW - Conformation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17238179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Pseudomonas+aeruginosa+Porin+OprF%3A+Properties+Of+The+Channel&rft.au=Nestorovich%2C+Ekaterina+M%3BSugawara%2C+Etsuko%3BNikaido%2C+Hiroshi%3BBezrukov%2C+Sergey+M&rft.aulast=Nestorovich&rft.aufirst=Ekaterina&rft.date=2006-06-01&rft.volume=281&rft.issue=24&rft.spage=16230&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Permeability; Lipid bilayers; Conductance; Kinetics; Porins; Outer membranes; Ion channels; Conformation; Escherichia coli; Pseudomonas aeruginosa ER - TY - JOUR T1 - Molecular Basis of L-Rhamnose Branch Formation in Streptococcal Coaggregation Receptor Polysaccharides AN - 17236340; 6947328 AB - The presence of L-rhamnose (Rha) branches in the coaggregation receptor polysaccharides (RPS) of Streptococcus gordonii 38 and Streptococcus oralis J22 was eliminated by replacement of wefB with ermAM in these strains. The expression of this gene in S. oralis 34 did not, however, result in the addition of Rha branches to the linear RPS of this strain, which is identical to that produced by the wefB-deficient mutant of S. gordonii 38. This paradoxical finding was explained by a subtle difference in acceptor specificity of the galactose-1-phosphotransferases encoded by downstream wefC in S. gordonii 38 and wefH in S. oralis 34. These genes were distinguished by the unique ability of WefC to act on the branched acceptor formed by the action of WefB. JF - Journal of Bacteriology AU - Yoshida, Yasuo AU - Ganguly, Soumya AU - Bush, CAllen AU - Cisar, John O AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892. Department of Chemistry and Biochemistry, University of Maryland-Baltimore County, Baltimore, Maryland 21250 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 4125 EP - 4130 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 11 SN - 0021-9193, 0021-9193 KW - WefC protein KW - wefB gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Streptococcus gordonii KW - L-Rhamnose KW - Polysaccharides KW - Streptococcus oralis KW - G 07320:Bacterial genetics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17236340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Molecular+Basis+of+L-Rhamnose+Branch+Formation+in+Streptococcal+Coaggregation+Receptor+Polysaccharides&rft.au=Yoshida%2C+Yasuo%3BGanguly%2C+Soumya%3BBush%2C+CAllen%3BCisar%2C+John+O&rft.aulast=Yoshida&rft.aufirst=Yasuo&rft.date=2006-06-01&rft.volume=188&rft.issue=11&rft.spage=4125&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - L-Rhamnose; Polysaccharides; Streptococcus gordonii; Streptococcus oralis ER - TY - JOUR T1 - Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study AN - 17234488; 6946478 AB - Adequate skeletal muscle strength is essential for physical functioning and low muscle strength is a predictor of physical limitations. Older adults with diabetes have a two- to threefold increased risk of physical disability. However, muscle strength has never been investigated with regard to diabetes in a population-based study. We evaluated grip and knee extensor strength and muscle mass in 485 older adults with diabetes and 2,133 without diabetes in the Health, Aging, and Body Composition study. Older adults with diabetes had greater arm and leg muscle mass than those without diabetes because they were bigger in body size. Despite this, muscle strength was lower in men with diabetes and not higher in women with diabetes than corresponding counterparts. Muscle quality, defined as muscle strength per unit regional muscle mass, was significantly lower in men and women with diabetes than those without diabetes in both upper and lower extremities. Furthermore, longer duration of diabetes ( greater than or equal to 6 years) and poor glycemic control (HbA sub(1c) >8.0%) were associated with even poorer muscle quality. In conclusion, diabetes is associated with lower skeletal muscle strength and quality. These characteristics may contribute to the development of physical disability in older adults with diabetes. JF - Diabetes AU - Park, Seok Won AU - Goodpaster, Bret H AU - Strotmeyer, Elsa S AU - de Rekeneire, Nathalie AU - Harris, Tamara B AU - Schwartz, Ann V AU - Tylavsky, Frances A AU - Newman, Anne B AD - Department of Internal Medicine, Pochon CHA University, Pochon, Korea. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia. Laboratory for Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland. Department of Epidemiology and Biostatistics, University of California, San Francisco, California. Department of Preventive Medicine, University of Tennessee, Memphis, Tennessee Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1813 EP - 1818 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA, [mailto:customerservice@diabetes.org], [URL:http://www.diabetes.org] VL - 55 IS - 6 SN - 0012-1797, 0012-1797 KW - Physical Education Index KW - Hands KW - Handicapped KW - Muscles (size) KW - Men KW - Women KW - Knees KW - Gerontology KW - Health KW - Legs KW - Adults KW - Diabetes KW - Strength KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17234488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Decreased+Muscle+Strength+and+Quality+in+Older+Adults+With+Type+2+Diabetes%3A+The+Health%2C+Aging%2C+and+Body+Composition+Study&rft.au=Park%2C+Seok+Won%3BGoodpaster%2C+Bret+H%3BStrotmeyer%2C+Elsa+S%3Bde+Rekeneire%2C+Nathalie%3BHarris%2C+Tamara+B%3BSchwartz%2C+Ann+V%3BTylavsky%2C+Frances+A%3BNewman%2C+Anne+B&rft.aulast=Park&rft.aufirst=Seok&rft.date=2006-06-01&rft.volume=55&rft.issue=6&rft.spage=1813&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hands; Handicapped; Muscles (size); Men; Women; Gerontology; Knees; Legs; Health; Adults; Diabetes; Strength; Body composition ER - TY - JOUR T1 - Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts AN - 17232482; 6950189 AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant-IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies have been performed in mice or rabbits to determine where in the body these plasmid vaccines would biodistribute and how rapidly they would clear. In the course of these studies, it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis. Even though similar to 10 super(14) molecules are inoculated in the studies in rabbits, by day 8 or 9 ( similar to 1 week postinoculation), already all but on the order of 10 super(4)-10 super(6) molecules per microgram of DNA extracted from tissue have been cleared at the injection site. Over the course of 2 months, the plasmid clears from the site of injection with only a small percentage of animals (generally 10-20%) retaining a small number of copies (generally around 100 copies) in the muscle at the injection site. This pattern of biodistribution (confined to the injection site) and clearance (within 2 months) is consistent regardless of differences in the promoter in the plasmid backbone or differences in the gene insert being expressed by the plasmid vaccine. In addition, integration has not been observed with plasmid vaccine candidates inoculated i.m. by Biojector 2000 or by needle and syringe. These data build on the repeated-dose toxicology studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. JF - Toxicological Sciences AU - Sheets, Rebecca L AU - Stein, Judith AU - Manetz, TScott AU - Duffy, Chris AU - Nason, Martha AU - Andrews, Charla AU - Kong, Wing-Pui AU - Nabel, Gary J AU - Gomez, Phillip L AD - U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 610 EP - 619 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 91 IS - 2 SN - 1096-6080, 1096-6080 KW - HIV-1 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Severe acute respiratory syndrome KW - Muscles KW - Ebola virus KW - Adjuvants KW - Plasmids KW - Integration KW - Promoters KW - Infectious diseases KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - DNA KW - Syringes KW - Cytokines KW - Vaccines KW - West Nile virus KW - Immunoglobulins KW - X 24240:Miscellaneous KW - N 14810:Methods KW - V 22004:AIDS: Clinical aspects KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Biodistribution+of+DNA+Plasmid+Vaccines+against+HIV-1%2C+Ebola%2C+Severe+Acute+Respiratory+Syndrome%2C+or+West+Nile+Virus+Is+Similar%2C+without+Integration%2C+despite+Differing+Plasmid+Backbones+or+Gene+Inserts&rft.au=Sheets%2C+Rebecca+L%3BStein%2C+Judith%3BManetz%2C+TScott%3BDuffy%2C+Chris%3BNason%2C+Martha%3BAndrews%2C+Charla%3BKong%2C+Wing-Pui%3BNabel%2C+Gary+J%3BGomez%2C+Phillip+L&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2006-06-01&rft.volume=91&rft.issue=2&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Severe acute respiratory syndrome; Muscles; Adjuvants; Plasmids; Promoters; Integration; DNA vaccines; Infectious diseases; DNA; Cytokines; Syringes; Vaccines; Immunoglobulins; Human immunodeficiency virus 1; Ebola virus; West Nile virus ER - TY - JOUR T1 - Active Transcription of rRNA Operons Is a Driving Force for the Distribution of RNA Polymerase in Bacteria: Effect of Extrachromosomal Copies of rrnB on the In Vivo Localization of RNA Polymerase AN - 17228467; 6947316 AB - In contrast to eukaryotes, bacteria such as Escherichia coli contain only one form of RNA polymerase (RNAP), which is responsible for all cellular transcription. Using an RNAP-green fluorescent protein fusion protein, we showed previously that E. coli RNAP is partitioned exclusively in the nucleoid and that stable RNA synthesis, particularly rRNA transcription, is critical for concentrating a significant fraction of RNAP in transcription foci during exponential growth. The extent of focus formation varies under different physiological conditions, supporting the proposition that RNAP redistribution is an important element for global gene regulation. Here we show that extra, plasmid-borne copies of an rRNA operon recruit RNAP from the nucleoid into the cytoplasmic space and that this is accompanied by a reduction in the growth rate. Transcription of an intact rRNA operon is not necessary, although a minimal transcript length is required for this phenotype. Replacement of the ribosomal promoters with another strong promoter, Ptac, abolished the effect. These results demonstrate that active synthesis from rRNA promoters is a major driving force for the distribution of RNAP in bacteria. The implications of our results for the regulation of rRNA synthesis and cell growth are discussed. JF - Journal of Bacteriology AU - Cabrera, Julio E AU - Jin, Ding J AD - Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702 Y1 - 2006/06/01/ PY - 2006 DA - 2006 Jun 01 SP - 4007 EP - 4014 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 11 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Growth rate KW - rRNA KW - Promoters KW - DNA-directed RNA polymerase KW - Gene regulation KW - Escherichia coli KW - Transcription KW - Nucleoids KW - Fusion protein KW - Operons KW - J 02310:Genetics & Taxonomy KW - G 07320:Bacterial genetics KW - A 01490:Miscellaneous KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17228467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Active+Transcription+of+rRNA+Operons+Is+a+Driving+Force+for+the+Distribution+of+RNA+Polymerase+in+Bacteria%3A+Effect+of+Extrachromosomal+Copies+of+rrnB+on+the+In+Vivo+Localization+of+RNA+Polymerase&rft.au=Cabrera%2C+Julio+E%3BJin%2C+Ding+J&rft.aulast=Cabrera&rft.aufirst=Julio&rft.date=2006-06-01&rft.volume=188&rft.issue=11&rft.spage=4007&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Growth rate; Promoters; rRNA; DNA-directed RNA polymerase; Gene regulation; Transcription; Nucleoids; Fusion protein; Operons; Escherichia coli ER - TY - JOUR T1 - Resistance of Streptococcus gordonii to Polymorphonuclear Leukocyte Killing Is a Potential Virulence Determinant of Infective Endocarditis AN - 17227303; 6946957 AB - Significant differences in virulence among seven representative Streptococcus gordonii strains were observed by using the rat model of infective endocarditis. Five strains, including S. gordonii DL1, caused severe disease, while the other two strains, including S. gordonii SK12, caused minimal or no disease. The differences in virulence were evident from the visible presence of streptococci in the vegetations present on the aortic valves of catheterized rats that were challenged with individual strains and also from the much greater recovery of rifampin-resistant S. gordonii DLl than of streptomycin-resistant S. gordonii SK12 from the hearts of animals coinfected with both organisms. Each S. gordonii strain aggregated with human platelets and bound to polymorphonuclear leukocytes (PMNs), as shown by the stimulation of PMN superoxide anion production. These interactions were reduced or abolished by pretreatment of the platelets or PMNs with sialidase, indicating that there was bacterial recognition of host sialic acid-containing receptors. Adhesin-mediated binding of each S. gordonii strain to PMNs also triggered phagocytosis. However, the subsequent PMN-dependent killing differed significantly for the seven strains. The five virulent strains included three strains that were not killed and two strains whose numbers were reduced by approximately 50%. In contrast, the level of killing of each avirulent strain under the same conditions was significantly greater and approached 90% of the bacteria added. Parallel studies performed with rat PMNs revealed comparable differences in the resistance or susceptibility of representative virulent and avirulent strains. Thus, the ability of S. gordonii to survive in PMNs following adhesin-mediated phagocytosis may be an important virulence determinant of infective endocarditis. JF - Infection and Immunity AU - Young Lee, Si AU - Cisar, John O AU - Bryant, Joseph L AU - Eckhaus, Michael A AU - Sandberg, Ann L AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research. Office of Research Services, Division of Veterinary Resources, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3148 EP - 3155 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Heart KW - Streptococcus gordonii KW - Leukocytes (polymorphonuclear) KW - Platelets KW - Animal models KW - superoxide anions KW - Phagocytosis KW - Endocarditis KW - F 06106:Bacteria KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17227303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Resistance+of+Streptococcus+gordonii+to+Polymorphonuclear+Leukocyte+Killing+Is+a+Potential+Virulence+Determinant+of+Infective+Endocarditis&rft.au=Young+Lee%2C+Si%3BCisar%2C+John+O%3BBryant%2C+Joseph+L%3BEckhaus%2C+Michael+A%3BSandberg%2C+Ann+L&rft.aulast=Young+Lee&rft.aufirst=Si&rft.date=2006-06-01&rft.volume=74&rft.issue=6&rft.spage=3148&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Heart; Virulence; Leukocytes (polymorphonuclear); Animal models; Platelets; superoxide anions; Phagocytosis; Endocarditis; Streptococcus gordonii ER - TY - JOUR T1 - Pesticides associated with Wheeze among Commercial Pesticide Applicators in the Agricultural Health Study AN - 17227252; 6944919 AB - Pesticides are potential risk factors for respiratory disease among farmers, but farmers are also exposed to other respiratory toxicants. To explore the association of pesticides with wheeze in a population without other farming exposures, the authors analyzed data from 2,255 Iowa commercial pesticide applicators enrolled in the Agricultural Health Study. Controlling for age, smoking status, asthma and atopy history, and body mass index, the authors calculated odds ratios for the relationship between wheeze and 36 individual pesticides participants had used during the year before enrollment (1993-1997). Eight of 16 herbicides were associated with wheeze in single-agent models; however, the risk was almost exclusively associated with the herbicide chlorimuron-ethyl (odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.25, 2.10). Inclusion of chlorimuron-ethyl in models for the other herbicides virtually eliminated the associations. The odds ratios for four organophosphate insecticides (terbufos, fonofos, chlorpyrifos, and phorate) were elevated when these chemicals were modeled individually and remained elevated, though attenuated somewhat, when chlorimuron-ethyl was included. The association for dichlorvos, another organophosphate insecticide, was not attenuated by chlorimuron-ethyl (OR = 2.48, 95% CI: 1.08, 5.66). Dose-response trends were observed for chlorimuron-ethyl, chlorpyrifos, and phorate; the strongest odds ratio was for applying chlorpyrifos on more than 40 days per year (OR = 2.40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl. JF - American Journal of Epidemiology AU - Hoppin, Jane A AU - Umbach, David M AU - London, Stephanie J AU - Lynch, Charles F AU - Alavanja, Michael CR AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1129 EP - 1137 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 163 IS - 12 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Toxicants KW - Organophosphates KW - phorate KW - Respiratory diseases KW - Models KW - Smoking KW - Insecticides KW - Dose-response effects KW - Risk factors KW - Occupational exposure KW - Dichlorvos KW - Data processing KW - Asthma KW - Herbicides KW - organophosphates KW - Agrochemicals KW - Chlorpyrifos KW - Atopy KW - USA, Iowa KW - Pesticides KW - Body mass index KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17227252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Pesticides+associated+with+Wheeze+among+Commercial+Pesticide+Applicators+in+the+Agricultural+Health+Study&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+CR%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-06-01&rft.volume=163&rft.issue=12&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Toxicants; phorate; Asthma; Herbicides; organophosphates; Models; Chlorpyrifos; Smoking; Insecticides; Atopy; Risk factors; Pesticides; Body mass index; Dichlorvos; Organophosphates; Dose-response effects; Respiratory diseases; Agrochemicals; Occupational exposure; USA, Iowa ER - TY - JOUR T1 - Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques AN - 17225708; 6929399 AB - Although replication-competent adenovirus (Ad) vectors are promising in AIDS vaccine design, their safety in immune compromised hosts is unknown. To initially address this question, enteric-coated tablets containing a replicating Ad vector were orally administered to SHIV- and SIV-infected rhesus macaques with normal, intermediate or low CD4 T cell counts and stable disease. The vector was detected within a week after tablet administration in stools of all animals but not in nasal secretions, indicating no spread of virus to the upper respiratory tract. CD4 T cell counts and viral loads remained stable in all animals and no signs of fever, weight loss, or other clinical symptoms of Ad- induced disease were observed during 10 weeks of follow-up. Oral delivery of the replicating Ad vector was safe and well tolerated by SHIV- and SIV-infected hosts. Oral enteric-coated tablets may prove safe for administering replicating Ad-vectored vaccines in areas with high HIV prevalence. JF - Vaccine AU - Gomez-Roman, VRaul AU - Grimes, George J AU - Potti, Gopal K AU - Peng, Bo AU - Demberg, Thorsten AU - Gravlin, Luisa AU - Treece, James AU - Pal, Ranajit AU - Lee, Eun Mi AU - Alvord, WGregory AU - Markham, Phillip D AU - Robert-Guroff, Marjorie AD - NIH, NCI, Vaccine Branch, Bethesda, MD 20892, United States, guroffm@exchange.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 5064 EP - 5072 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 23 SN - 0264-410X, 0264-410X KW - HIV KW - Rhesus monkey KW - SIV KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Replication-competent adenovirus vectors KW - Rhesus macaque KW - SIV/SHIV KW - Acquired immune deficiency syndrome KW - Secretions KW - Adenovirus KW - Tablets KW - Oral administration KW - Vectors KW - Expression vectors KW - Fever KW - CD4 antigen KW - Human immunodeficiency virus KW - Lymphocytes T KW - Macaca mulatta KW - Vaccines KW - Feces KW - Simian immunodeficiency virus KW - Respiratory tract KW - W3 33365:Vaccines (other) KW - V 22005:AIDS: Epidemiological aspects KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17225708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Oral+delivery+of+replication-competent+adenovirus+vectors+is+well+tolerated+by+SIV-+and+SHIV-infected+rhesus+macaques&rft.au=Gomez-Roman%2C+VRaul%3BGrimes%2C+George+J%3BPotti%2C+Gopal+K%3BPeng%2C+Bo%3BDemberg%2C+Thorsten%3BGravlin%2C+Luisa%3BTreece%2C+James%3BPal%2C+Ranajit%3BLee%2C+Eun+Mi%3BAlvord%2C+WGregory%3BMarkham%2C+Phillip+D%3BRobert-Guroff%2C+Marjorie&rft.aulast=Gomez-Roman&rft.aufirst=VRaul&rft.date=2006-06-01&rft.volume=24&rft.issue=23&rft.spage=5064&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.03.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fever; Expression vectors; Acquired immune deficiency syndrome; CD4 antigen; Secretions; Oral administration; Lymphocytes T; Tablets; Vectors; Vaccines; Feces; Respiratory tract; Human immunodeficiency virus; Adenovirus; Macaca mulatta; Simian immunodeficiency virus DO - http://dx.doi.org/10.1016/j.vaccine.2006.03.048 ER - TY - JOUR T1 - Structural Classification of Bacterial Response Regulators: Diversity of Output Domains and Domain Combinations AN - 17224560; 6947336 AB - CheY-like phosphoacceptor (or receiver [REC]) domain is a common module in a variety of response regulators of the bacterial signal transduction systems. In this work, 4,610 response regulators, encoded in complete genomes of 200 bacterial and archaeal species, were identified and classified by their domain architectures. Previously uncharacterized output domains were analyzed and, in some cases, assigned to known domain families. Transcriptional regulators of the OmpR, NarL, and NtrC families were found to comprise almost 60% of all response regulators; transcriptional regulators with other DNA-binding domains (LytTR, AraC, Spo0A, Fis, YcbB, RpoE, and MerR) account for an additional 6%. The remaining one-third is represented by the stand-alone REC domain ( similar to 14%) and its combinations with a variety of enzymatic (GGDEF, EAL, HD-GYP, CheB, CheC, PP2C, and HisK), RNA-binding (ANTAR and CsrA), protein- or ligand-binding (PAS, GAF, TPR, CAP_ED, and HPt) domains, or newly described domains of unknown function. The diversity of domain architectures and the abundance of alternative domain combinations suggest that fusions between the REC domain and various output domains is a widespread evolutionary mechanism that allows bacterial cells to regulate transcription, enzyme activity, and/or protein-protein interactions in response to environmental challenges. The complete list of response regulators encoded in each of the 200 analyzed genomes is available online at http://www.ncbi.nlm.nih.gov/Complete_Genomes/RRcensus.html. JF - Journal of Bacteriology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 4169 EP - 4182 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 12 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteria KW - DNA-binding protein KW - Transcription KW - Enzymes KW - Protein interaction KW - Evolution KW - Signal transduction KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17224560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Structural+Classification+of+Bacterial+Response+Regulators%3A+Diversity+of+Output+Domains+and+Domain+Combinations&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-06-01&rft.volume=188&rft.issue=12&rft.spage=4169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; DNA-binding protein; Enzymes; Transcription; Evolution; Protein interaction; Signal transduction; Bacteria ER - TY - JOUR T1 - 4-1BB ligand enhances tumor-specific immunity of poxvirus vaccines AN - 17223627; 6929390 AB - Purpose Recombinant poxvirus vaccines have been explored as tumor vaccines. The immunogenicity of these vaccines can be enhanced by co-expressing costimulatory molecules and tumor-associated antigens. While the B7-CD28 interaction has been most comprehensively investigated, other costimulatory molecules utilize different signaling pathways and might provide further cooperation in T cell priming and survival. 4-1BB (CD137) is a TNF family member and is critical for activation and long-term maintenance of primed T cells. This study was conducted to determine if a poxvirus expressing the ligand for 4-1BB (4-1BBL) could further improve the immune and therapeutic responses of a previously reported poxvirus vaccine expressing a triad of costimulatory molecules (B7.1, ICAM-1, and LFA-3). Experimental design A recombinant vaccinia virus expressing 4-1BBL was generated and characterized in an in vitro infection system. This vaccine was then used alone or in combination with a vaccinia virus expressing CEA, B7.1, ICAM-1, and LFA-3 in CEA-transgenic mice bearing established MC38 tumors. Tumor growth and immune responses against CEA and other tumor-associated antigens were determined. The level of anti-apoptotic proteins in responding T cells was determined by flow cytometry on tetramer selected T cells. Results The combination of 4-1BBL with B7.1-based poxvirus vaccination resulted in significantly enhanced therapeutic effects against CEA-expressing tumors in a CEA-transgenic mouse model. This was associated with an increased level of CEA-specific CD4 super(+) and CD8 super(+) T cell responses, induction of antigen spreading to p53 and gp70, increased accumulation of CEA-specific T cells in the tumor microenvironment, and increased expression of bcl-X sub(L) and bcl-2 in CD4 super(+) and CD8 super(+) T cells in vaccinated mice. Conclusion 4-1BBL cooperates with B7 in enhancing anti-tumor and immunologic responses in a recombinant poxvirus vaccine model. The inclusion of costimulatory molecules targeting distinct T cell signaling pathways provides a mechanism for enhancing the therapeutic effectiveness of tumor vaccines. JF - Vaccine AU - Kudo-Saito, Chie AU - Hodge, James W AU - Kwak, Heesun AU - Kim-Schulze, Seunghee AU - Schlom, Jeffrey AU - Kaufman, Howard L AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States, hlk2003@columbia.edu Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 4975 EP - 4986 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 23 SN - 0264-410X, 0264-410X KW - 4-1BB protein KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Cancer KW - Costimulation KW - 4-1BBL KW - Poxviruses KW - Vaccine KW - Cancer vaccines KW - CD137 antigen KW - Tumor necrosis factor KW - Carcinoembryonic antigen KW - CD8 antigen KW - Flow cytometry KW - CD4 antigen KW - Vaccinia virus KW - Poxvirus KW - Antigen (tumor-associated) KW - intercellular adhesion molecule 1 KW - Lymphocytes T KW - Vaccines KW - Signal transduction KW - W3 33350:Cancer vaccines KW - F 06150:Immunotherapy KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17223627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=4-1BB+ligand+enhances+tumor-specific+immunity+of+poxvirus+vaccines&rft.au=Kudo-Saito%2C+Chie%3BHodge%2C+James+W%3BKwak%2C+Heesun%3BKim-Schulze%2C+Seunghee%3BSchlom%2C+Jeffrey%3BKaufman%2C+Howard+L&rft.aulast=Kudo-Saito&rft.aufirst=Chie&rft.date=2006-06-01&rft.volume=24&rft.issue=23&rft.spage=4975&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.03.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Cancer vaccines; CD4 antigen; Tumor necrosis factor; CD137 antigen; intercellular adhesion molecule 1; Carcinoembryonic antigen; Antigen (tumor-associated); Lymphocytes T; CD8 antigen; Vaccines; Signal transduction; Vaccinia virus; Poxvirus DO - http://dx.doi.org/10.1016/j.vaccine.2006.03.042 ER - TY - JOUR T1 - Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth AN - 17215667; 6880456 AB - 4,5-dihydroxy-2,3-pentanedione (DPD), a product of the LuxS enzyme in the catabolism of S-ribosylhomocysteine, spontaneously cyclizes to form autoinducer 2 (AI-2). AI-2 is proposed to be a universal signal molecule mediating interspecies communication among bacteria. We show that mutualistic and abundant biofilm growth in flowing saliva of two human oral commensal bacteria, Actinomyces naeslundii T14V and Streptococcus oralis 34, is dependent upon production of AI-2 by S. oralis 34. A luxS mutant of S. oralis 34 was constructed which did not produce AI-2. Unlike wild-type dual-species biofilms, A. naeslundii T14V and an S. oralis 34 luxS mutant did not exhibit mutualism and generated only sparse biofilms which contained a 10-fold lower biomass of each species. Restoration of AI-2 levels by genetic or chemical (synthetic AI-2 in the form of DPD) complementation re-established the mutualistic growth and high biomass characteristic for the wild-type dual-species biofilm. Furthermore, an optimal concentration of DPD was determined, above and below which biofilm formation was suppressed. The optimal concentration was 100-fold lower than the detection limit of the currently accepted AI-2 assay. Thus, AI-2 acts as an interspecies signal and its concentration is critical for mutualism between two species of oral bacteria grown under conditions that are representative of the human oral cavity. JF - Molecular Microbiology AU - Rickard, Alexander H AU - Palmer, Robert J AU - Blehert, David S AU - Campagna, Shawn R AU - Semmelhack, Martin F AU - Egland, Paul G AU - Bassler, Bonnie L AU - Kolenbrander, Paul E AD - National Institutes of Health, NIDCR, Bethesda, MD 20892, USA, pkolenbrander@dir.nidcr.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1446 EP - 1456 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 60 IS - 6 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - LuxS protein KW - Commensals KW - Communication KW - Enzymes KW - Biomass KW - Actinomyces naeslundii KW - Oral cavity KW - Complementation KW - Mutualism KW - Biofilms KW - Saliva KW - N-octanoylhomoserine lactone KW - Streptococcus oralis KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17215667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Autoinducer+2%3A+a+concentration-dependent+signal+for+mutualistic+bacterial+biofilm+growth&rft.au=Rickard%2C+Alexander+H%3BPalmer%2C+Robert+J%3BBlehert%2C+David+S%3BCampagna%2C+Shawn+R%3BSemmelhack%2C+Martin+F%3BEgland%2C+Paul+G%3BBassler%2C+Bonnie+L%3BKolenbrander%2C+Paul+E&rft.aulast=Rickard&rft.aufirst=Alexander&rft.date=2006-06-01&rft.volume=60&rft.issue=6&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05202.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - SuppNotes - Figures, 9; references, 34. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - LuxS protein; Complementation; Communication; Commensals; Mutualism; Enzymes; Saliva; Biofilms; Biomass; Oral cavity; N-octanoylhomoserine lactone; Bacteria; Actinomyces naeslundii; Streptococcus oralis DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05202.x ER - TY - JOUR T1 - Translation Arrest Requires Two-Way Communication between a Nascent Polypeptide and the Ribosome AN - 17197459; 6865957 AB - When the export of E. coli SecM is blocked, a 17 amino acid motif near the C terminus of the protein induces a translation arrest from within the ribosome tunnel. Here we used a recently described application of fluorescence resonance energy transfer (FRET) to gain insight into the mechanism of translation arrest. We found that the SecM C terminus adopted a compact conformation upon synthesis of the arrest motif. This conformational change did not occur spontaneously, but rather was induced by the ribosome. Translation arrest required both compaction of the SecM C terminus and the presence of key residues in the arrest motif. Further analysis showed that the arrested peptidyl-tRNA was resistant to puromycin treatment and revealed additional changes in the ribosome-nascent SecM complex. Based on these observations, we propose that translation arrest results from a series of reciprocal interactions between the ribosome and the C terminus of the nascent SecM polypeptide. JF - Molecular Cell AU - Woolhead, Cheryl A AU - Johnson, Arthur E AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, harris_bernstein@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 587 EP - 598 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 22 IS - 5 SN - 1097-2765, 1097-2765 KW - SecM protein KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - RNA KW - Translation KW - Amino acids KW - Escherichia coli KW - fluorescence resonance energy transfer KW - Ribosomes KW - Compaction KW - puromycin KW - J 02726:RNA and ribosomes KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17197459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=Translation+Arrest+Requires+Two-Way+Communication+between+a+Nascent+Polypeptide+and+the+Ribosome&rft.au=Woolhead%2C+Cheryl+A%3BJohnson%2C+Arthur+E%3BBernstein%2C+Harris+D&rft.aulast=Woolhead&rft.aufirst=Cheryl&rft.date=2006-06-01&rft.volume=22&rft.issue=5&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Molecular+Cell&rft.issn=10972765&rft_id=info:doi/10.1016%2Fj.molcel.2006.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Translation; Amino acids; fluorescence resonance energy transfer; Ribosomes; Compaction; puromycin; Escherichia coli DO - http://dx.doi.org/10.1016/j.molcel.2006.05.021 ER - TY - JOUR T1 - The prevalence of drinking and driving in the United States, 2001-2002: Results from the national epidemiological survey on alcohol and related conditions AN - 17193829; 6865634 AB - Traffic deaths and injuries are among the most frequent causes of deaths and disability worldwide. In the United States, the National Highway Transportation Safety Administration (NHTSA) reported that approximately 40% of all traffic fatalities were alcohol-related. Yet, information about the prevalence of drinking and driving behaviors of the U.S. general population is lacking. The purpose of this study was to examine the magnitude of driver-based (i.e., driving while drinking and driving after having too much to drink) and passenger-based (i.e., riding with a drinking driver and riding as a passenger while drinking) drinking and driving behaviors confronting contemporary America. The past-year prevalence data were stratified by major sociodemographic characteristics to identify important determinants of drinking and driving behaviors for further research. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n = 43,093). In 2001-2002 there were 23.4 million, or 11.3%, of American adults who reported engaging in at least one of the four driver- or passenger-based drinking and driving behaviors. The prevalences of passenger-based drinking and driving behaviors were generally greater than those of the driver-based measures. For all four drinking and driving behaviors, age was inversely associated with the risk and males were at greater risk with the associated male-to-female ratios of approximately 3.0. Our data also suggested that Native Americans, individuals who were widowed/separated/divorced or never married, and those with greater than a high school education were also at greater risks of all drinking and driving behaviors. JF - Drug and Alcohol Dependence AU - Chou, SPatricia AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Huang, Boji AU - Pickering, Roger P AU - Zhou, Yuan AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, 5635 Fishers Lane, MS 9304, Bethesda, MD 20892-9304, United States, pchou@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 137 EP - 146 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 83 IS - 2 SN - 0376-8716, 0376-8716 KW - Health & Safety Science Abstracts KW - Prevalence KW - Drinking and driving KW - Sex differentials KW - Alcohol KW - Mortality KW - USA KW - Education KW - driving ability KW - Motor vehicles KW - Traffic safety KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17193829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+prevalence+of+drinking+and+driving+in+the+United+States%2C+2001-2002%3A+Results+from+the+national+epidemiological+survey+on+alcohol+and+related+conditions&rft.au=Chou%2C+SPatricia%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BHuang%2C+Boji%3BPickering%2C+Roger+P%3BZhou%2C+Yuan%3BGrant%2C+Bridget+F&rft.aulast=Chou&rft.aufirst=SPatricia&rft.date=2006-06-01&rft.volume=83&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Alcohol; Education; driving ability; Motor vehicles; Traffic safety; Ethnic groups; USA DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.11.001 ER - TY - JOUR T1 - A nonradioactive, cell-free method for measuring protein synthesis inhibition by Pseudomonas exotoxin AN - 17179111; 6860322 AB - Pseudomonas exotoxin A (PE) inhibits protein synthesis by NAD-dependent ADP- ribosylation of eukaryotic elongation factor 2. Traditionally, toxin activity has been characterized, either in living cells or cell-free systems, using radioactive compounds for quantification. The increased costs of radioactive waste disposal together with heightened security concerns have made the use of radioactive isotopes less attractive for routine laboratory assays. We therefore adapted a cell-free rabbit reticulocyte in vitro transcription-translation system that utilizes a reporter ( beta -galactosidase) to measure toxin activity. The assay for PE is rapid, scalable, log-linear, NAD dependent and can be used to assess the neutralizing activity of anti-PE antibody preparations. JF - Analytical Biochemistry AU - Pastrana, Diana V AU - FitzGerald, David J AD - Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA, djpf@helix.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 266 EP - 271 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 353 IS - 2 SN - 0003-2697, 0003-2697 KW - Microbiology Abstracts B: Bacteriology KW - Toxin KW - Nonradioactive KW - Inhibition of protein synthesis KW - Pseudomonas KW - ADP-ribosylation KW - Reticulocyte KW - Isotopes KW - Protein biosynthesis KW - beta -Galactosidase KW - Radioactive wastes KW - Transcription KW - Cell-free system KW - ribosylation KW - exotoxin A KW - Exotoxins KW - Toxins KW - Elongation KW - Antibodies KW - NAD KW - Reticulocytes KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17179111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+nonradioactive%2C+cell-free+method+for+measuring+protein+synthesis+inhibition+by+Pseudomonas+exotoxin&rft.au=Pastrana%2C+Diana+V%3BFitzGerald%2C+David+J&rft.aulast=Pastrana&rft.aufirst=Diana&rft.date=2006-06-01&rft.volume=353&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2006.03.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Isotopes; Protein biosynthesis; beta -Galactosidase; Radioactive wastes; Transcription; Cell-free system; ribosylation; exotoxin A; Toxins; Exotoxins; Elongation; Antibodies; NAD; Reticulocytes; Pseudomonas DO - http://dx.doi.org/10.1016/j.ab.2006.03.043 ER - TY - JOUR T1 - Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors AN - 17169878; 6836555 AB - super(11)C-labeled (+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1- methylpiperidin-3-yl]methylsulfanyl]ethanol ([ super(11)C]5) and (+)-trans-2- [[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl ] -1- (piperidin-1-yl)ethanone ([ super(11)C]6) were synthesized and evaluated as new imaging agents for the norepinephrine transporter (NET). [ super(11)C]5 and [ super(11)C]6 display high affinity for the NET in vitro (K sub(i) = 0.94 and 0.68 nM, respectively) and significant selectivity over the dopamine (DAT) and serotonin transporters (SERT). Because of their high affinity and favorable transporter selectivities we speculated that these ligands might serve as useful PET agents for imaging NET in vivo. Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT. JF - Bioorganic and Medicinal Chemistry Letters AU - Musachio, John L AU - Hong, Jinsoo AU - Ichise, Masanori AU - Seneca, Nicholas AU - Brown, Amira K AU - Liow, Jeih-San AU - Halldin, Christer AU - Innis, Robert B AU - Pike, Victor W AU - He, Rong AU - Zhou, Jia AU - Kozikowski, Alan P AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892-1003, USA, kozikowa@uic.edu Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3101 EP - 3104 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 12 SN - 0960-894X, 0960-894X KW - nocaine KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Monoamine transporter KW - Brain KW - Dopamine transporter KW - Norepinephrine transporter KW - Hybrids KW - modafinil KW - Positron emission tomography KW - Serotonin transporter KW - W 30910:Imaging KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17169878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Development+of+new+brain+imaging+agents+based+upon+nocaine-modafinil+hybrid+monoamine+transporter+inhibitors&rft.au=Musachio%2C+John+L%3BHong%2C+Jinsoo%3BIchise%2C+Masanori%3BSeneca%2C+Nicholas%3BBrown%2C+Amira+K%3BLiow%2C+Jeih-San%3BHalldin%2C+Christer%3BInnis%2C+Robert+B%3BPike%2C+Victor+W%3BHe%2C+Rong%3BZhou%2C+Jia%3BKozikowski%2C+Alan+P&rft.aulast=Musachio&rft.aufirst=John&rft.date=2006-06-01&rft.volume=16&rft.issue=12&rft.spage=3101&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.03.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Dopamine transporter; Serotonin transporter; Norepinephrine transporter; Monoamine transporter; Hybrids; Brain; Positron emission tomography; modafinil DO - http://dx.doi.org/10.1016/j.bmcl.2006.03.066 ER - TY - JOUR T1 - Using induced accelerations to understand knee stability during gait of individuals with muscle weakness AN - 17168131; 6836826 AB - The purpose of this case series was to quantify the effectiveness of different compensatory strategies used by individuals with muscle weakness to produce knee extension during the stance phase gait. Subjects were three males with less than anti-gravity strength in the quadriceps femoris and a variable pattern of weakness elsewhere in the lower extremity. They walked independently at a self-selected speed without assistive devices. Gait analysis of the pelvis and bilateral lower extremity segments was performed with a six-camera, two force platform motion capture system. Joint angles and net internal moments were computed from the motion data. Induced acceleration analysis was performed to quantify the relative ability of each lower extremity joint moment and gravity to produce knee angular acceleration. Results showed that a variety of adaptive strategies both within and across limbs can control knee position during gait. One subject generated knee extension almost exclusively via the hip extensor moment. Another relied less on the hip extensor moment (39%) and more on the ankle plantar flexor moment (61%) to create knee extension. The third subject used the ipsilateral hip extensor moment (24%) and the contralateral ankle plantar flexor moment (67%) to assist knee extension. The strategy selected by each subject likely was influenced by both their total pattern of impairments and the effectiveness of the available compensations. This case series demonstrates how an induced acceleration analysis can augment a traditional gait analysis to expand and enhance our understanding of compensatory movement control strategies. JF - Gait & Posture AU - Siegel, Karen Lohmann AU - Kepple, Thomas M AU - Stanhope, Steven J AD - Physical Disabilities Branch, National Institutes of Health, Department of Health and Human Services, Building 10, CRC, Room 1-1469, 10 Center Drive, MSC 1604, Bethesda, MD 20892, USA, karen_siegel@nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 435 EP - 440 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 23 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Weakness KW - Gait KW - Quadriceps femoris KW - Compensation KW - Motor control KW - Gravity KW - Strategy KW - Force platforms KW - Ankles KW - Knees KW - Legs KW - Muscles (fatigue) KW - Stability KW - Movement KW - Acceleration KW - Hips KW - Joints KW - Pelvis KW - Speed KW - Strength KW - Analysis KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Using+induced+accelerations+to+understand+knee+stability+during+gait+of+individuals+with+muscle+weakness&rft.au=Siegel%2C+Karen+Lohmann%3BKepple%2C+Thomas+M%3BStanhope%2C+Steven+J&rft.aulast=Siegel&rft.aufirst=Karen&rft.date=2006-06-01&rft.volume=23&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2005.05.007 LA - English DB - Physical Education Index N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gravity; Force platforms; Strategy; Knees; Ankles; Legs; Muscles (fatigue); Stability; Acceleration; Movement; Hips; Joints; Pelvis; Strength; Speed; Analysis; Gait; Motor control DO - http://dx.doi.org/10.1016/j.gaitpost.2005.05.007 ER - TY - JOUR T1 - Kinematic and EMG characteristics of simple shoulder movements with proprioception and visual feedback AN - 17154163; 6822101 AB - The objective of this study was to determine if simple, shoulder movements use the dual control hypothesis strategy, previously demonstrated with elbow movements, and to see if this strategy also applies in the absence of visual feedback. Twenty subjects were seated with their right arm abducted to 90 degree and externally rotated in the scapular plane. Subjects internally rotated to a target position using a custom shoulder wheel at three different speeds with and without visual feedback. Kinematics were collected with a motion analysis system and electromyographic (EMG) recordings of the pectoralis major (PECT), infraspinatus (INFRA), anterior and posterior (ADELT, PDELT) deltoid muscles were used to evaluate muscle activity patterns during movements. Kinematics changed as movement speed increased with less accuracy (p - 0.01). Greater EMG activity was observed in the PECT, PDELT, and INFRA with shorter durations for the ADELT, PDELT and INFRA. Movements with only kinesthetic feedback were less accurate (p - 0.01) and performed faster (p - 0.01) than movements with visual feedback. EMG activity suggests no major difference in CNS control strategies in movements with and without visual feedback. Greater resolution with visual feedback enables the implementation of a dual control strategy, allowing greater movement velocity while maintaining accuracy. JF - Journal of Electromyography and Kinesiology AU - Brindle, Timothy J AU - Nitz, Arthur J AU - Uhl, Tim L AU - Kifer, Edward AU - Shapiro, Robert AD - Physical Disabilities Branch, National Institutes of Health, Building 10- CRC, Room 1-1425 MCS 1604, Bethesda, MD 20892-1604, USA, tbrindle@cc.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 236 EP - 249 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 16 IS - 3 SN - 1050-6411, 1050-6411 KW - Physical Education Index KW - Upper extremity KW - EMG KW - Kinematics KW - Kinesthesia KW - Strategy KW - Electromyography KW - Velocity KW - Accuracy KW - Muscles (activity) KW - Movement KW - Kinesthesis KW - Speed KW - Elbows KW - Analysis KW - Shoulders KW - Feedback KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17154163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Electromyography+and+Kinesiology&rft.atitle=Kinematic+and+EMG+characteristics+of+simple+shoulder+movements+with+proprioception+and+visual+feedback&rft.au=Brindle%2C+Timothy+J%3BNitz%2C+Arthur+J%3BUhl%2C+Tim+L%3BKifer%2C+Edward%3BShapiro%2C+Robert&rft.aulast=Brindle&rft.aufirst=Timothy&rft.date=2006-06-01&rft.volume=16&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Journal+of+Electromyography+and+Kinesiology&rft.issn=10506411&rft_id=info:doi/10.1016%2Fj.jelekin.2005.06.012 LA - English DB - Physical Education Index N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Kinematics; Strategy; Electromyography; Accuracy; Velocity; Muscles (activity); Movement; Kinesthesis; Speed; Elbows; Analysis; Feedback; Shoulders DO - http://dx.doi.org/10.1016/j.jelekin.2005.06.012 ER - TY - JOUR T1 - The utilization of pediatric computed tomography in a large Israeli Health Maintenance Organization AN - 1468366093; 18520335 AB - Background: Concern has been raised about the potential risks related to radiation exposure from CT scans, particularly among children. However, to date, there are few data available describing the magnitude of pediatric CT utilization. Objective: The aim of the study was to explore patterns of CT use in pediatric patients, with respect to time, use of multiple scans, body regions imaged, and medical diagnoses. Materials and methods: Records of 22,223 scans performed on 18,075 people aged less than or equal to 18 years over the period 1999-2003, including diagnoses recorded within 21 days after the examination, were obtained from a large Israeli Health Maintenance Organization (1,600,000 members). Results: The highest annual CT examination rate (per 1,000) was recorded in 2001 (10.1) compared to 7.0 and 6.3 in 1999 and 2003, respectively. The lowest rate (three scans per 1,000) was found for 3-year-old children, with increasing rates with age. The head was the most frequently scanned region, both in young children (78%) and adolescents (39%). Symptoms of ill-defined conditions and injuries were documented in 22% and 10% of all scans, respectively. Conclusions: Although the results suggest that children comprise only 3% of all patients undergoing CT, this important modality must be carefully used because of their increased radiosensitivity, higher effective radiation doses, and longer life expectancy. JF - Pediatric Radiology AU - Chodick, Gabriel AU - Ronckers, Cecile AU - Ron, Elaine AU - Shalev, Varda AD - Maccabi Healthcare Services, 27 Ha'Mered Street, Tel Aviv, 68125, Israel, Chodickg@mail.nih.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 485 EP - 490 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 36 IS - 6 SN - 0301-0449, 0301-0449 KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Data processing KW - Radiation KW - Head KW - Injuries KW - Pediatrics KW - Adolescence KW - Computed tomography KW - Life span KW - Radiosensitivity KW - Children KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1468366093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Radiology&rft.atitle=The+utilization+of+pediatric+computed+tomography+in+a+large+Israeli+Health+Maintenance+Organization&rft.au=Chodick%2C+Gabriel%3BRonckers%2C+Cecile%3BRon%2C+Elaine%3BShalev%2C+Varda&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2006-06-01&rft.volume=36&rft.issue=6&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Pediatric+Radiology&rft.issn=03010449&rft_id=info:doi/10.1007%2Fs00247-005-0091-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Injuries; Head; Radiation; Pediatrics; Adolescence; Life span; Computed tomography; Radiosensitivity; Children DO - http://dx.doi.org/10.1007/s00247-005-0091-0 ER - TY - JOUR T1 - Differentiated object priority control mechanism for MPEG-4 streaming. AN - 57653936; 420016 AB - An MPEG-4 multimedia movie may involve hundreds of audio-video objects, which complicate object-based transmission and presentation. This study proposes a differentiated object priority control (DOPC) system for MPEG-4 streaming. The DOPC system is based on standard MPEG-4 DMIF architecture and combines object priority, layer adaptation and TFRC (TCP friendly rate control) congestion control schemes. The DOPC system achieves harmonic streaming transmission using the proposed differentiated transmission schedule strategy (DTS(super 2)). The basic control approach of DTS is to proportionally differentiate the bandwidth and adjust the object qualities for different media streams based on the priority assignment of media objects. When the network situation is poor, the DTS(super 2) mechanism continues to provide a smooth presentation by effectively decreasing the transmission bandwidth of some of the lower priority media objects to achieve transmission adaptation control. The evaluation results indicate that the proposed DTS(super 2) mechanism provide harmonic bandwidth differentiation. (Author abstract) JF - Computer Communications AU - Kung, Hsu-Yang AU - Chen, Chun-Yuan AU - Wu, Chi-I AD - Department of Management Information Systems, National Pingtung University of Science and Technology, 1 Hsueh Fu Rd., Nei Pu Hsiang, Pingtung 91207, Taiwan, ROC kung@mail.npust.edu.tw Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 SP - 1522 EP - 1537 PB - Elsevier Ltd (NL) VL - 29 IS - 9 SN - 0140-3664, 0140-3664 KW - Multimedia KW - MPEG KW - Networks KW - Standards KW - Video KW - 0: NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57653936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Communications&rft.atitle=Differentiated+object+priority+control+mechanism+for+MPEG-4+streaming.&rft.au=Kung%2C+Hsu-Yang%3BChen%2C+Chun-Yuan%3BWu%2C+Chi-I&rft.aulast=Kung&rft.aufirst=Hsu-Yang&rft.date=2006-05-31&rft.volume=29&rft.issue=9&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=Computer+Communications&rft.issn=01403664&rft_id=info:doi/10.1016%2Fj.comcom.2005.09.012 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2006-08-15 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Networks; Video; Multimedia; Standards; MPEG DO - http://dx.doi.org/10.1016/j.comcom.2005.09.012 ER - TY - CPAPER T1 - Incentives and Disincentives for Cognitive Aging T2 - 13th Annual Meeting of the Psychoneuroimmunology Research Society (PNIRS 2006) AN - 40129046; 4292596 JF - 13th Annual Meeting of the Psychoneuroimmunology Research Society (PNIRS 2006) AU - Ingram, Donald Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Aging KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Psychoneuroimmunology+Research+Society+%28PNIRS+2006%29&rft.atitle=Incentives+and+Disincentives+for+Cognitive+Aging&rft.au=Ingram%2C+Donald&rft.aulast=Ingram&rft.aufirst=Donald&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Psychoneuroimmunology+Research+Society+%28PNIRS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pnirs2006.org/images/stories/pnirs2006_programme.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accelerometer-Measured Physical Activity Prevalence in NHANES 2003-2004 T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40119314; 4274740 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Troiano, Richard Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Physical activity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40119314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Accelerometer-Measured+Physical+Activity+Prevalence+in+NHANES+2003-2004&rft.au=Troiano%2C+Richard&rft.aulast=Troiano&rft.aufirst=Richard&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross-Sectional Correlation between Corrected Pedometer Step Counts and Characteristics of Metabolic Disorders in American Indians T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40072217; 4276087 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Pomeroy, Jeremy AU - Brage, Soren AU - Begay, Toricellas AU - Curtis, Jeff AU - Wareham, Nicholas J AU - Troiano, Richard AU - Leitzmann, Michael F AU - Franks, Paul W Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Metabolic disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40072217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Cross-Sectional+Correlation+between+Corrected+Pedometer+Step+Counts+and+Characteristics+of+Metabolic+Disorders+in+American+Indians&rft.au=Pomeroy%2C+Jeremy%3BBrage%2C+Soren%3BBegay%2C+Toricellas%3BCurtis%2C+Jeff%3BWareham%2C+Nicholas+J%3BTroiano%2C+Richard%3BLeitzmann%2C+Michael+F%3BFranks%2C+Paul+W&rft.aulast=Pomeroy&rft.aufirst=Jeremy&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analytic Decisions Applied to the NHANES Accelerometer Data T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40066779; 4274739 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Masse, Louise Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Accelerometers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Analytic+Decisions+Applied+to+the+NHANES+Accelerometer+Data&rft.au=Masse%2C+Louise&rft.aulast=Masse&rft.aufirst=Louise&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - HYBRID SPECIATION IN WILD SUNFLOWERS1 AN - 20157617; 8701630 AB - Hybrid speciation refers to the establishment of novel hybrid genotypes that are reproductively isolated from their parental species and genetically stabilized. Most frequently, reproductive isolation is achieved via an increase in ploidy. However, in some instances new hybrid species arise and become reproductively isolated without a change in chromosome number, a process known as diploid or 'homoploid' hybrid speciation. The annual sunflowers of the genus Helianthus provide a well-studied example of this latter mode of speciation. Here, I review this work, placing individual studies in their proper context. These include (1) computer simulations that describe the evolutionary conditions under which hybrid speciation is most likely; (2) molecular phylogenetic studies that document the origins of three hybrid sunflower species; (3) comparative genetic mapping studies that describe the karyotypic changes associated with hybrid speciation; (4) experimental re-creations of homoploid hybrid species that allow genotypic and phenotypic comparisons between synthetic and ancient hybrid lineages; (5) quantitative trait locus (QTL) studies that describe the genetic basis of phenotypic differences between the parental species and the mode of gene action underlying the generation of extreme phenotypes in hybrids; (6) phylogeographic studies that estimate the ages and number of origins of each hybrid species; (7) selection studies that measure the strength of selection on individual traits and QTLs in synthetic hybrids transplanted into hybrid habitats; and (8) candidate gene studies that search for correlations between candidate genes for ecological divergence and traits and QTLs shown to be under selection in the habitats of the hybrid species. Ongoing work includes searches for the molecular signature of selection during hybrid speciation, surveys of gene expression shifts associated with hybrid speciation, and experiments that evaluate the role of new hybrid gene combinations versus reproductive isolation in the ecological divergence of hybrid lineages. JF - Annals of the Missouri Botanical Garden AU - Rieseberg, Loren H AD - 1 The author's research on homoploid hybrid speciation has been supported by the U.S. National Science Foundation and the National Institutes of Health. Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 SP - 34 EP - 48 PB - Missouri Botanical Garden VL - 93 IS - 1 SN - 0026-6493, 0026-6493 KW - Ecology Abstracts KW - Quantitative trait loci KW - Speciation KW - Reproductive isolation KW - Reviews KW - Hybrids KW - Ploidy KW - Habitat KW - Evolution KW - Helianthus KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20157617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+Missouri+Botanical+Garden&rft.atitle=HYBRID+SPECIATION+IN+WILD+SUNFLOWERS1&rft.au=Rieseberg%2C+Loren+H&rft.aulast=Rieseberg&rft.aufirst=Loren&rft.date=2006-05-31&rft.volume=93&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+Missouri+Botanical+Garden&rft.issn=00266493&rft_id=info:doi/10.3417%2F0026-6493%282006%29932.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Helianthus; Hybrids; Speciation; Reproductive isolation; Habitat; Quantitative trait loci; Ploidy; Evolution; Reviews DO - http://dx.doi.org/10.3417/0026-6493(2006)93[34:HSIWS]2.0.CO;2 ER - TY - CPAPER T1 - Intimate Partner Alcohol Problems: Their Impact on the Physical and Mental Health of Married/Cohabiting Women T2 - 32nd Alcohol Epidemiology Symposium AN - 40036246; 4269976 JF - 32nd Alcohol Epidemiology Symposium AU - Dawson, Deborah Y1 - 2006/05/29/ PY - 2006 DA - 2006 May 29 KW - Alcohols UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40036246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Alcohol+Epidemiology+Symposium&rft.atitle=Intimate+Partner+Alcohol+Problems%3A+Their+Impact+on+the+Physical+and+Mental+Health+of+Married%2FCohabiting+Women&rft.au=Dawson%2C+Deborah&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2006-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Alcohol+Epidemiology+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.parthen-impact.com/eventure/publicSciProgram.do LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury AN - 223932797; 16714768 AB - Background The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established. Methods We evaluated the relationship of benefits and risks of PACs in 1000 patients with established acute lung injury in a randomized trial comparing hemodynamic management guided by a PAC with hemodynamic management guided by a central venous catheter (CVC) using an explicit management protocol. Mortality during the first 60 days before discharge home was the primary outcome. Results The groups had similar baseline characteristics. The rates of death during the first 60 days before discharge home were similar in the PAC and CVC groups (27.4 percent and 26.3 percent, respectively; P=0.69; absolute difference, 1.1 percent; 95 percent confidence interval, -4.4 to 6.6 percent), as were the mean (±SE) numbers of both ventilator-free days (13.2±0.5 and 13.5±0.5; P=0.58) and days not spent in the intensive care unit (12.0±0.4 and 12.5±0.5; P=0.40) to day 28. PAC-guided therapy did not improve these measures for patients in shock at the time of enrollment. There were no significant differences between groups in lung or kidney function, rates of hypotension, ventilator settings, or use of dialysis or vasopressors. Approximately 90 percent of protocol instructions were followed in both groups, with a 1 percent rate of crossover from CVC- to PAC-guided therapy. Fluid balance was similar in the two groups, as was the proportion of instructions given for fluid and diuretics. Dobutamine use was uncommon. The PAC group had approximately twice as many catheter-related complications (predominantly arrhythmias). Conclusions PAC-guided therapy did not improve survival or organ function but was associated with more complications than CVC-guided therapy. These results, when considered with those of previous studies, suggest that the PAC should not be routinely used for the management of acute lung injury. (ClinicalTrials.gov number, NCT00281268 .) JF - The New England Journal of Medicine AU - Wheeler, Arthur P AU - Bernard, Gordon R AU - B Taylor Thompson AU - Schoenfeld, David AU - et al Y1 - 2006/05/25/ PY - 2006 DA - 2006 May 25 SP - 2213 EP - 24 CY - Boston PB - Massachusetts Medical Society VL - 354 IS - 21 SN - 00284793 KW - Medical Sciences KW - Lungs KW - Injuries KW - Catheters KW - Pulmonary arteries KW - Clinical trials KW - Medical treatment KW - Respiratory Distress Syndrome, Adult -- mortality KW - Analysis of Variance KW - Arrhythmias, Cardiac -- etiology KW - Blood Pressure KW - Humans KW - Kidney -- physiology KW - Respiration, Artificial KW - Respiratory Physiological Phenomena KW - Respiratory Distress Syndrome, Adult -- etiology KW - Comorbidity KW - Pulmonary Artery -- physiology KW - Fluid Therapy KW - Treatment Outcome KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Middle Aged KW - Water-Electrolyte Balance KW - Female KW - Male KW - Survival Analysis KW - Catheterization, Central Venous -- adverse effects KW - Respiratory Distress Syndrome, Adult -- therapy KW - Catheterization, Swan-Ganz -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223932797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Pulmonary-Artery+versus+Central+Venous+Catheter+to+Guide+Treatment+of+Acute+Lung+Injury&rft.au=Wheeler%2C+Arthur+P%3BBernard%2C+Gordon+R%3BB+Taylor+Thompson%3BSchoenfeld%2C+David%3Bet+al&rft.aulast=Wheeler&rft.aufirst=Arthur&rft.date=2006-05-25&rft.volume=354&rft.issue=21&rft.spage=2213&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2006 Massachusetts Medical Society. All rights reserved. N1 - Document feature - Charts; Tables; Graphs; References N1 - Last updated - 2014-05-02 N1 - CODEN - NEJMAG ER - TY - JOUR T1 - Evolutionary tinkering with transposable elements. AN - 68005797; 16705033 JF - Proceedings of the National Academy of Sciences of the United States of America AU - Jordan, I King AD - National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA. jordan@ncbi.nlm.nih.gov Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 SP - 7941 EP - 7942 VL - 103 IS - 21 SN - 0027-8424, 0027-8424 KW - DNA Transposable Elements KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Biological Evolution KW - Kinetics KW - Humans KW - DNA -- metabolism KW - Repetitive Sequences, Nucleic Acid KW - Protein Structure, Tertiary KW - Time Factors KW - Mutagenesis, Insertional KW - Evolution, Molecular KW - Genetic Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68005797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Evolutionary+tinkering+with+transposable+elements.&rft.au=Jordan%2C+I+King&rft.aulast=Jordan&rft.aufirst=I&rft.date=2006-05-23&rft.volume=103&rft.issue=21&rft.spage=7941&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8101-6 [16672366] Curr Opin Genet Dev. 1999 Dec;9(6):657-63 [10607616] Nature. 2001 Feb 15;409(6822):860-921 [11237011] Evolution. 2001 Jan;55(1):1-24 [11263730] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Q Rev Biol. 1971 Jun;46(2):111-38 [5160087] Science. 1977 Jun 10;196(4295):1161-6 [860134] Nature. 1980 Apr 17;284(5757):601-3 [6245369] Proc Natl Acad Sci U S A. 1992 May 1;89(9):4018-22 [1315047] Nature. 1992 Jun 18;357(6379):543-4 [1608464] Nature. 1997 Jan 9;385(6612):111-2 [8990106] Gene. 1997 Dec 31;205(1-2):203-17 [9461395] Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18075-80 [16332963] Comment On: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8101-6 [16672366] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Flash Floods in Bulgaria T2 - Conference on Water Observation and Information System for Decision Support (BALWOIS 2006) AN - 40075888; 4254498 JF - Conference on Water Observation and Information System for Decision Support (BALWOIS 2006) AU - Gergov, George AU - Filkov, Ivan AU - Karagiozova, Tzviatka AU - Pencheva, Katia Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 KW - Bulgaria KW - Floods KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40075888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Water+Observation+and+Information+System+for+Decision+Support+%28BALWOIS+2006%29&rft.atitle=Flash+Floods+in+Bulgaria&rft.au=Gergov%2C+George%3BFilkov%2C+Ivan%3BKaragiozova%2C+Tzviatka%3BPencheva%2C+Katia&rft.aulast=Gergov&rft.aufirst=George&rft.date=2006-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Water+Observation+and+Information+System+for+Decision+Support+%28BALWOIS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.balwois.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of the CBL Model YORCON with Experimental and Climate Data from Sofia T2 - Conference on Water Observation and Information System for Decision Support (BALWOIS 2006) AN - 40000188; 4254441 JF - Conference on Water Observation and Information System for Decision Support (BALWOIS 2006) AU - Maria, Kolarova AU - Dimiter, Yordanov AU - Nedialko, Valkov AU - Dimiter, Syrakov Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 KW - Bulgaria, Sofia KW - Cbl protein KW - Climate KW - Models KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Water+Observation+and+Information+System+for+Decision+Support+%28BALWOIS+2006%29&rft.atitle=Comparison+of+the+CBL+Model+YORCON+with+Experimental+and+Climate+Data+from+Sofia&rft.au=Maria%2C+Kolarova%3BDimiter%2C+Yordanov%3BNedialko%2C+Valkov%3BDimiter%2C+Syrakov&rft.aulast=Maria&rft.aufirst=Kolarova&rft.date=2006-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Water+Observation+and+Information+System+for+Decision+Support+%28BALWOIS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.balwois.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Measurement of Multisite Oxidation Kinetics Reveals an Active Site Conformational Change in Spo0F as a Result of Protein Oxidation AN - 19398659; 7156838 AB - When most proteins undergo oxidative damage, they yield a variety of products containing oxidative damage at a large number of sites, most of which are modified substoichiometrically. The resulting complex mixture of products is not amenable to high-resolution structural analyses. The previous methods of structural analysis have relied upon either very generalized structural analyses such as circular dichroism or the creation of a battery of mutants to try to isolate single-residue damage effects. We present a methodology using mass spectrometry to measure the kinetics of oxidation at many sites simultaneously. Previous studies have shown that these kinetics are determined by the chemical nature of the damage site and by the accessibility of that site to the radical. By measuring deviations in the rate of oxidation from the expected pseudo-zero-order kinetics, we can detect and characterize local structural changes due to the oxidative damage. We demonstrate the application of this new technique to the Spo0F protein, a regulator of sporulation in Bacillus subtilis. Circular dichroism studies suggest a partial loss of helical structure of Spo0F as a result of oxidative damage. We report that oxidation causes a three-stage conformational change in Spo0F. Furthermore, we find the dramatic structural changes affect only the region surrounding the active site, while the remainder of the structure remains relatively unperturbed. Finally, we are able to determine that the specific oxidation event that triggers the conformational change at the active site of Spo0F occurs at Met81, a partially conserved methionine in the CheY superfamily. JF - Biochemistry (Washington) AU - Sharp, J S AU - Sullivan, D M AU - Cavanagh, J AU - Tomer, K B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/05/23/ PY - 2006 DA - 2006 May 23 SP - 6260 EP - 6266 VL - 45 IS - 20 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Kinetics KW - C.D. KW - Oxidation KW - Sporulation KW - Mass spectroscopy KW - Methionine KW - Radicals KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19398659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Measurement+of+Multisite+Oxidation+Kinetics+Reveals+an+Active+Site+Conformational+Change+in+Spo0F+as+a+Result+of+Protein+Oxidation&rft.au=Sharp%2C+J+S%3BSullivan%2C+D+M%3BCavanagh%2C+J%3BTomer%2C+K+B&rft.aulast=Sharp&rft.aufirst=J&rft.date=2006-05-23&rft.volume=45&rft.issue=20&rft.spage=6260&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi060470r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - C.D.; Kinetics; Oxidation; Sporulation; Methionine; Mass spectroscopy; Radicals; Bacillus subtilis DO - http://dx.doi.org/10.1021/bi060470r ER - TY - JOUR T1 - Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01. AN - 67977042; 16705314 AB - Histone deacetylase inhibitors (HDACIs) are novel anticancer agents with potent cytotoxicity against a wide range of malignancies. We have previously demonstrated that either Calphostin C (CC) (a protein kinase C (PKC) inhibitor) or Parthenolide (an NF-kappaB inhibitor) abrogates HDACI-induced transcriptional activation of NF-kappaB and p21, which is associated with profound potentiation of HDACI-mediated induction of apoptosis. Valproic acid (VA), a commonly used antiepileptic agent, has recently been shown to be an HDACI. This study was aimed to evaluate the anticancer property of VA in thoracic cancer cells and the development of clinically relevant strategies to enhance VA-mediated induction of apoptosis using kinase inhibitors Staurosporine (STP) or its analogue UCN-01. Treating cultured thoracic cancer cells with VA (0.62-10.0 mM) resulted in significant cell line- and dose-dependent growth inhibition (IC(50) values: 4.1-6.0 mM) and cell cycle arrest at G1/S checkpoint with profound accumulation of cells at G0/G1 phase but little induction of apoptosis. Valproic acid, being an HDACI, caused significant dose-dependent accumulation of hyperacetylated histones, following 24 h of treatment. Valproic acid-mediated 5-20-fold upregulation of transcriptional activity of NF-kappaB was substantially (50-90%) suppressed by cotreatment with CC, STP or UCN-01. Whereas minimal death (<20%) was observed in cells treated with either VA (1.0 or 5.0 mM) alone or kinase inhibitors alone, 60-90% of cells underwent apoptosis following exposure to combinations of VA+kinase inhibitors. Kinase inhibitor-mediated suppression of NF-kappaB transcriptional activity played an important role in sensitising cancer cells to VA as direct inhibition of NF-kappaB by Parthenolide drastically synergised with VA to induce apoptosis (VA+Parthenolide: 60-90% compared to <20% following single-drug treatments). In conclusion, VA, a well-known antiepileptic drug, has mild growth-inhibitory activity on cultured cancer cells. The weak VA-mediated induction of apoptosis of thoracic cancer cells can be profoundly enhanced either by Parthenolide, a pharmacologic inhibitor of NF-kappaB, or by UCN-01 a kinase inhibitor that has already undergone phase I clinical development. Combinations of VA with either a PKC inhibitor or an NF-kappaB inhibitor are promising novel molecularly targeted therapeutics for thoracic cancers. JF - British journal of cancer AU - Yeow, W-S AU - Ziauddin, M F AU - Maxhimer, J B AU - Shamimi-Noori, S AU - Baras, A AU - Chua, A AU - Schrump, D S AU - Nguyen, D M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2006/05/22/ PY - 2006 DA - 2006 May 22 SP - 1436 EP - 1445 VL - 94 IS - 10 SN - 0007-0920, 0007-0920 KW - Anticonvulsants KW - 0 KW - Antineoplastic Agents KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - NF-kappa B KW - Valproic Acid KW - 614OI1Z5WI KW - 7-hydroxystaurosporine KW - 7BU5H4V94A KW - Staurosporine KW - H88EPA0A3N KW - Index Medicus KW - Tumor Cells, Cultured KW - Dose-Response Relationship, Drug KW - Humans KW - Apoptosis -- drug effects KW - Drug Synergism KW - NF-kappa B -- genetics KW - NF-kappa B -- metabolism KW - Valproic Acid -- pharmacology KW - Neoplasms -- drug therapy KW - Anticonvulsants -- pharmacology KW - Staurosporine -- pharmacology KW - Neoplasms -- pathology KW - Enzyme Inhibitors -- pharmacology KW - Staurosporine -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67977042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Potentiation+of+the+anticancer+effect+of+valproic+acid%2C+an+antiepileptic+agent+with+histone+deacetylase+inhibitory+activity%2C+by+the+kinase+inhibitor+Staurosporine+or+its+clinically+relevant+analogue+UCN-01.&rft.au=Yeow%2C+W-S%3BZiauddin%2C+M+F%3BMaxhimer%2C+J+B%3BShamimi-Noori%2C+S%3BBaras%2C+A%3BChua%2C+A%3BSchrump%2C+D+S%3BNguyen%2C+D+M&rft.aulast=Yeow&rft.aufirst=W-S&rft.date=2006-05-22&rft.volume=94&rft.issue=10&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=00070920&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2006-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Nov 15;163(10):5617-23 [10553091] Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3578-88 [14506144] J Clin Oncol. 2001 Apr 15;19(8):2319-33 [11304786] Cancer Res. 2001 Jul 1;61(13):5106-15 [11431348] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8 [11535817] Mol Pharmacol. 2001 Oct;60(4):828-37 [11562446] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] Oncogene. 2002 Mar 7;21(11):1727-38 [11896604] Cancer Res. 2003 Dec 1;63(23):8420-7 [14679005] Expert Opin Investig Drugs. 2004 Jan;13(1):21-38 [14680450] Cancer Res. 2004 Feb 1;64(3):1079-86 [14871841] Mol Pharmacol. 2004 Mar;65(3):571-81 [14978235] Clin Cancer Res. 2004 Mar 1;10(5):1813-25 [15014036] Invest New Drugs. 2004 Aug;22(3):299-305 [15122077] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4029-37 [15217935] Curr Pharm Des. 2004;10(19):2289-98 [15279609] J Biol Chem. 2004 Aug 6;279(32):33759-67 [15175348] Surgery. 2004 Aug;136(2):416-25 [15300209] Lancet. 1988 Jul 23;2(8604):189-92 [2899663] Mol Pharmacol. 1994 Jun;45(6):1207-14 [8022414] N Engl J Med. 1996 Jan 18;334(3):168-75 [8531974] FEBS Lett. 1997 Jan 27;402(1):85-90 [9013864] Nature. 1997 Sep 25;389(6649):349-52 [9311776] Genes Dev. 1998 Mar 1;12(5):599-606 [9499396] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7 [9501205] Prog Nucleic Acid Res Mol Biol. 1998;61:379-422 [9752726] Clin Cancer Res. 2004 Nov 1;10(21):7192-8 [15534092] J Thorac Cardiovasc Surg. 2005 Jan;129(1):53-63 [15632825] Cancer Res. 2005 Mar 15;65(6):2422-32 [15781658] Cell Cycle. 2005 Apr;4(4):549-51 [15738652] Semin Oncol. 2005 Oct;32(5):488-502 [16210090] J Natl Cancer Inst. 2002 Apr 3;94(7):504-13 [11929951] Med Res Rev. 2002 Sep;22(5):492-511 [12210556] Blood. 2002 Nov 1;100(9):3333-43 [12384435] Cancer Res. 2002 Nov 1;62(21):6108-15 [12414635] Mol Cancer Ther. 2002 Feb;1(4):253-66 [12467221] J Biol Chem. 2003 May 23;278(21):18980-9 [12649266] J Thorac Cardiovasc Surg. 2003 May;125(5):1132-42 [12771887] EMBO J. 2003 Jul 1;22(13):3411-20 [12840003] Oncogene. 2003 Sep 4;22(38):6023-31 [12955081] Cell Cycle. 2003 Sep-Oct;2(5):467-72 [12963846] Oncogene. 2003 Sep 18;22(40):6231-42 [13679862] J Biol Chem. 1999 Dec 3;274(49):34940-7 [10574969] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Appropriation of the Sigma70 Subunit of RNA Polymerase: Structural Remodeling of Sigma70 Region 4 by the Bacteriophage T4 AsiA Protein T2 - 106th General Meeting of the American Society for Microbiology AN - 40157449; 4152806 JF - 106th General Meeting of the American Society for Microbiology AU - Hinton, Deborah M Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Asia KW - Phages KW - DNA-directed RNA polymerase KW - AsiA protein KW - Bacteriophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40157449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Appropriation+of+the+Sigma70+Subunit+of+RNA+Polymerase%3A+Structural+Remodeling+of+Sigma70+Region+4+by+the+Bacteriophage+T4+AsiA+Protein&rft.au=Hinton%2C+Deborah+M&rft.aulast=Hinton&rft.aufirst=Deborah&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poxvirus Multiprotein Entry-Fusion Complex T2 - 106th General Meeting of the American Society for Microbiology AN - 40141345; 4152866 JF - 106th General Meeting of the American Society for Microbiology AU - Moss, Bernard Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Phages KW - Poxvirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Poxvirus+Multiprotein+Entry-Fusion+Complex&rft.au=Moss%2C+Bernard&rft.aulast=Moss&rft.aufirst=Bernard&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function of E. coli Stringent Starvation Protein A (SspA): Phage P1 Development, Host Acid Tolerance and Pathogenesis T2 - 106th General Meeting of the American Society for Microbiology AN - 40141217; 4152808 JF - 106th General Meeting of the American Society for Microbiology AU - Jin, Ding J Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Phages KW - Starvation KW - Viral diseases KW - Bacteriophages KW - Escherichia coli KW - Phage P1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Function+of+E.+coli+Stringent+Starvation+Protein+A+%28SspA%29%3A+Phage+P1+Development%2C+Host+Acid+Tolerance+and+Pathogenesis&rft.au=Jin%2C+Ding+J&rft.aulast=Jin&rft.aufirst=Ding&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Segregation Dynamics of the Escherichia coli Chromosome T2 - 106th General Meeting of the American Society for Microbiology AN - 40124395; 4152945 JF - 106th General Meeting of the American Society for Microbiology AU - Austin, S Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Chromosomes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Segregation+Dynamics+of+the+Escherichia+coli+Chromosome&rft.au=Austin%2C+S&rft.aulast=Austin&rft.aufirst=S&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wilms Tumor Pathogenesis is Facilitated by Serine Phosphorylation of Stat1 T2 - 37th Annual Meeting of the American Pediatric Surgical Association (APSA 2006) AN - 40121995; 4289398 JF - 37th Annual Meeting of the American Pediatric Surgical Association (APSA 2006) AU - Timofeeva, Olga AU - Lovvorn III, Harold N AU - Opperman, Shaun AU - Perantoni, Alan O Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Serine KW - Phosphorylation KW - Stat1 protein KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+of+the+American+Pediatric+Surgical+Association+%28APSA+2006%29&rft.atitle=Wilms+Tumor+Pathogenesis+is+Facilitated+by+Serine+Phosphorylation+of+Stat1&rft.au=Timofeeva%2C+Olga%3BLovvorn+III%2C+Harold+N%3BOpperman%2C+Shaun%3BPerantoni%2C+Alan+O&rft.aulast=Timofeeva&rft.aufirst=Olga&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+of+the+American+Pediatric+Surgical+Association+%28APSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eapsa.org/surgeons/meeting/detailed.htm#fdt LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression by the Plague Bacterium Within the Flea Vector T2 - 106th General Meeting of the American Society for Microbiology AN - 40120875; 4152903 JF - 106th General Meeting of the American Society for Microbiology AU - Hinnebusch, B Joseph Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Expression vectors KW - Gene expression KW - Plague KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40120875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Gene+Expression+by+the+Plague+Bacterium+Within+the+Flea+Vector&rft.au=Hinnebusch%2C+B+Joseph&rft.aulast=Hinnebusch&rft.aufirst=B&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Target Membrane Organization in HIV Entry T2 - 106th General Meeting of the American Society for Microbiology AN - 40120740; 4152833 JF - 106th General Meeting of the American Society for Microbiology AU - Blumenthal, Robert Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Membranes KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40120740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Role+of+Target+Membrane+Organization+in+HIV+Entry&rft.au=Blumenthal%2C+Robert&rft.aulast=Blumenthal&rft.aufirst=Robert&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodefense Priorities T2 - 106th General Meeting of the American Society for Microbiology AN - 40120619; 4152787 JF - 106th General Meeting of the American Society for Microbiology AU - Kurilla, Michael Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Bioterrorism KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40120619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Biodefense+Priorities&rft.au=Kurilla%2C+Michael&rft.aulast=Kurilla&rft.aufirst=Michael&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Yersinia pestis with its Flea Vector that Lead to the Transmission of Plague T2 - 106th General Meeting of the American Society for Microbiology AN - 40098969; 4152845 JF - 106th General Meeting of the American Society for Microbiology AU - Hinnebusch, B Joseph Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Disease transmission KW - Vectors KW - Plague KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40098969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Interactions+of+Yersinia+pestis+with+its+Flea+Vector+that+Lead+to+the+Transmission+of+Plague&rft.au=Hinnebusch%2C+B+Joseph&rft.aulast=Hinnebusch&rft.aufirst=B&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Designing Trials to Develop Adaptive Treatment Strategies to Treat Prescription Opioid Dependence T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40095444; 4270059 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Levy, Janet Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Opioids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Designing+Trials+to+Develop+Adaptive+Treatment+Strategies+to+Treat+Prescription+Opioid+Dependence&rft.au=Levy%2C+Janet&rft.aulast=Levy&rft.aufirst=Janet&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Implementation of Centralized Oversight of Consent Forms for a Large Multicenter NIH-Sponsored Clinical Trial: The ACCORD Experience T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40094782; 4270101 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Rosenberg, Yves Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40094782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Implementation+of+Centralized+Oversight+of+Consent+Forms+for+a+Large+Multicenter+NIH-Sponsored+Clinical+Trial%3A+The+ACCORD+Experience&rft.au=Rosenberg%2C+Yves&rft.aulast=Rosenberg&rft.aufirst=Yves&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Some Considerations in the Early Stopping of Clinical Trials for Efficacy T2 - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AN - 40032427; 4270048 JF - 27th Annual Meeting of the Society for Clinical Trials (SCT 2006) AU - Dixon, Dennis Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40032427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.atitle=Some+Considerations+in+the+Early+Stopping+of+Clinical+Trials+for+Efficacy&rft.au=Dixon%2C+Dennis&rft.aulast=Dixon&rft.aufirst=Dennis&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2006files/2006_Prelim_program_part_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mycobacterium abscessus: Pathophysiology and Treatment in 2006 T2 - 106th General Meeting of the American Society for Microbiology AN - 39183220; 4152693 JF - 106th General Meeting of the American Society for Microbiology AU - Holland, Steven M Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Mycobacterium abscessus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39183220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Mycobacterium+abscessus%3A+Pathophysiology+and+Treatment+in+2006&rft.au=Holland%2C+Steven+M&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on the BMBL and Implications for Laboratory Research T2 - 106th General Meeting of the American Society for Microbiology AN - 39156185; 4152573 JF - 106th General Meeting of the American Society for Microbiology AU - Wilson, Deborah E Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Experimental research KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39156185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Update+on+the+BMBL+and+Implications+for+Laboratory+Research&rft.au=Wilson%2C+Deborah+E&rft.aulast=Wilson&rft.aufirst=Deborah&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of Brucella with ER T2 - 106th General Meeting of the American Society for Microbiology AN - 39155928; 4152553 JF - 106th General Meeting of the American Society for Microbiology AU - Celli, Jean Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Microbiology KW - Pathogens KW - Brucella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39155928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Interaction+of+Brucella+with+ER&rft.au=Celli%2C+Jean&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleoid Structure and Transcription Profile T2 - 106th General Meeting of the American Society for Microbiology AN - 39155719; 4152496 JF - 106th General Meeting of the American Society for Microbiology AU - Adhya, Sankar Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Nucleoids KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39155719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Nucleoid+Structure+and+Transcription+Profile&rft.au=Adhya%2C+Sankar&rft.aulast=Adhya&rft.aufirst=Sankar&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evasion of Innate Host Defense by Community-Acquired MRSA T2 - 106th General Meeting of the American Society for Microbiology AN - 39149092; 4152744 DE: JF - 106th General Meeting of the American Society for Microbiology AU - DeLeo, Frank R Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39149092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evasion+of+Innate+Host+Defense+by+Community-Acquired+MRSA&rft.au=DeLeo%2C+Frank+R&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Biology of Staphylococcus epidermidis Pathogenesis T2 - 106th General Meeting of the American Society for Microbiology AN - 39148774; 4152601 JF - 106th General Meeting of the American Society for Microbiology AU - Otto, Michael Y1 - 2006/05/21/ PY - 2006 DA - 2006 May 21 KW - Molecular biology KW - Staphylococcus epidermidis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39148774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Biology+of+Staphylococcus+epidermidis+Pathogenesis&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2006-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=106th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. AN - 67987848; 16710025 AB - Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 are associated with autoimmune disease. Trials of the anti-CTLA4 antibody ipilimumab (MDX-010) have resulted in durable cancer regression and immune-mediated toxicities. A report on the diagnosis, pathology, treatment, clinical outcome, and significance of the immune-mediated enterocolitis seen with ipilimumab is presented. We treated 198 patients with metastatic melanoma (MM) or renal cell carcinoma (RCC) with ipilimumab. The overall objective tumor response rate was 14%. We observed several immune mediated toxicities including dermatitis, enterocolitis, hypophysitis, uveitis, hepatitis, and nephritis. Enterocolitis, defined by grade 3/4 clinical presentation and/or biopsy documentation, was the most common major toxicity (21% of patients). It presented with diarrhea, and biopsies showed both neutrophilic and lymphocytic inflammation. Most patients who developed enterocolitis responded to high-dose systemic corticosteroids. There was no evidence that steroid administration affected tumor responses. Five patients developed perforation or required colectomy. Four other patients with steroid-refractory enterocolitis appeared to respond promptly to tumor necrosis factor alpha blockade with infliximab. Objective tumor response rates in patients with enterocolitis were 36% for MM and 35% for RCC, compared with 11% and 2% in patients without enterocolitis, respectively (P = .0065 for MM and P = .0016 for RCC). CTLA4 seems to be a significant component of tolerance to tumor and in protection against immune mediated enterocolitis and these phenomena are significantly associated in cancer patients. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Beck, Kimberly E AU - Blansfield, Joseph A AU - Tran, Khoi Q AU - Feldman, Andrew L AU - Hughes, Marybeth S AU - Royal, Richard E AU - Kammula, Udai S AU - Topalian, Suzanne L AU - Sherry, Richard M AU - Kleiner, David AU - Quezado, Martha AU - Lowy, Israel AU - Yellin, Michael AU - Rosenberg, Steven A AU - Yang, James C AD - Surgery Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA. Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 SP - 2283 EP - 2289 VL - 24 IS - 15 KW - Adrenal Cortex Hormones KW - 0 KW - Antibodies, Monoclonal KW - Antigens, CD KW - Antigens, Differentiation KW - Antineoplastic Agents KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Cancer Vaccines KW - Ctla4 protein, mouse KW - Gastrointestinal Agents KW - ipilimumab KW - 6T8C155666 KW - Infliximab KW - B72HH48FLU KW - Index Medicus KW - Kidney Neoplasms -- drug therapy KW - Humans KW - Carcinoma, Renal Cell -- drug therapy KW - Skin Neoplasms -- drug therapy KW - Adrenal Cortex Hormones -- therapeutic use KW - Melanoma -- drug therapy KW - Middle Aged KW - Gastrointestinal Agents -- therapeutic use KW - Female KW - Male KW - Neoplasms -- drug therapy KW - Enterocolitis -- chemically induced KW - Antigens, Differentiation -- immunology KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Enterocolitis -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67987848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Enterocolitis+in+patients+with+cancer+after+antibody+blockade+of+cytotoxic+T-lymphocyte-associated+antigen+4.&rft.au=Beck%2C+Kimberly+E%3BBlansfield%2C+Joseph+A%3BTran%2C+Khoi+Q%3BFeldman%2C+Andrew+L%3BHughes%2C+Marybeth+S%3BRoyal%2C+Richard+E%3BKammula%2C+Udai+S%3BTopalian%2C+Suzanne+L%3BSherry%2C+Richard+M%3BKleiner%2C+David%3BQuezado%2C+Martha%3BLowy%2C+Israel%3BYellin%2C+Michael%3BRosenberg%2C+Steven+A%3BYang%2C+James+C&rft.aulast=Beck&rft.aufirst=Kimberly&rft.date=2006-05-20&rft.volume=24&rft.issue=15&rft.spage=2283&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-07 N1 - Date created - 2006-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2003 Apr 15;170(8):3939-43 [12682220] J Immunol. 2001 May 15;166(10):6430-6 [11342669] Nat Genet. 2001 Jan;27(1):68-73 [11138001] Nat Genet. 2001 Jan;27(1):20-1 [11137993] N Engl J Med. 2000 Sep 14;343(11):750-8 [10984562] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] J Exp Med. 2000 Jul 17;192(2):295-302 [10899916] Curr Opin Pediatr. 2001 Dec;13(6):533-8 [11753102] Lancet. 2001 Jun 16;357(9272):1925-8 [11425413] Immunity. 1995 Nov;3(5):541-7 [7584144] J Exp Med. 1995 Aug 1;182(2):459-65 [7543139] Immunity. 1994 Aug;1(5):405-13 [7882171] Science. 1996 Mar 22;271(5256):1734-6 [8596936] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] J Immunol. 1996 Aug 15;157(4):1333-6 [8759711] Immunol Rev. 1996 Oct;153:27-46 [9010718] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4712-7 [12682289] Nature. 2003 May 29;423(6939):506-11 [12724780] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Immunol. 2003 Dec 1;171(11):6251-9 [14634142] Bone Marrow Transplant. 2004 Jun;33(12):1235-9 [15077127] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] Nature. 1986 Jul 17-23;322(6076):268-71 [3090449] Gastroenterology. 2005 Jun;128(7):2020-8 [15940634] J Clin Oncol. 2005 Feb 1;23(4):741-50 [15613700] Am J Gastroenterol. 2004 Dec;99(12):2376-84 [15571586] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] Blood. 1999 May 15;93(10):3267-75 [10233878] J Exp Med. 1998 Feb 2;187(3):427-32 [9449722] Comment In: J Clin Oncol. 2006 Dec 1;24(34):5469-70; author reply 5470-1 [17135653] J Clin Oncol. 2006 May 20;24(15):2230-2 [16710020] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Cytometric Analysis of a Novel, Autologous Cell Culture System Capable of Producing High-Levels of Autologous HIV-1 for Individualized Therapeutic Vaccination T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40061323; 4220263 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Trubey, Charles M.A.C. AU - Lifson, Jeffrey D Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Vaccination KW - Cell culture KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40061323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Cytometric+Analysis+of+a+Novel%2C+Autologous+Cell+Culture+System+Capable+of+Producing+High-Levels+of+Autologous+HIV-1+for+Individualized+Therapeutic+Vaccination&rft.au=Trubey%2C+Charles+M.A.C.%3BLifson%2C+Jeffrey+D&rft.aulast=Trubey&rft.aufirst=Charles&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Population of IGD+CD27- B Cells with Similarities to Activated Splenic Marginal Zone B Cells is Found in the Blood of Patients with Active Systemic Lupus Erythematosus, Correlates with Disease Activity, and is Sensitive to IL6 Receptor Blockade T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40061025; 4220193 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Fischer, Randy Thomas AU - Okada, Sarah AU - Lugar, Patricia AU - Slota, Rebecca AU - Yarboro, Cheryl AU - Longo, Nancy S AU - Hardin, John AU - Illei, Gabor G AU - Lipsky, Peter E AU - Grammer, Amrie C Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Blood KW - Lymphocytes B KW - Spleen KW - Systemic lupus erythematosus KW - Interleukin 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40061025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=A+Population+of+IGD%2BCD27-+B+Cells+with+Similarities+to+Activated+Splenic+Marginal+Zone+B+Cells+is+Found+in+the+Blood+of+Patients+with+Active+Systemic+Lupus+Erythematosus%2C+Correlates+with+Disease+Activity%2C+and+is+Sensitive+to+IL6+Receptor+Blockade&rft.au=Fischer%2C+Randy+Thomas%3BOkada%2C+Sarah%3BLugar%2C+Patricia%3BSlota%2C+Rebecca%3BYarboro%2C+Cheryl%3BLongo%2C+Nancy+S%3BHardin%2C+John%3BIllei%2C+Gabor+G%3BLipsky%2C+Peter+E%3BGrammer%2C+Amrie+C&rft.aulast=Fischer&rft.aufirst=Randy&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filo: An Unbiased Spatial Analysis of Fish Signals in Interphase Nuclei T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40060092; 4219846 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Gudla, Prabhakar Reddy AU - Yee, Addison Z AU - Takizawa, Takumi AU - Misteli, Tom AU - Lockett, Stephen J Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Pisces KW - Nuclei KW - Interphase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Filo%3A+An+Unbiased+Spatial+Analysis+of+Fish+Signals+in+Interphase+Nuclei&rft.au=Gudla%2C+Prabhakar+Reddy%3BYee%2C+Addison+Z%3BTakizawa%2C+Takumi%3BMisteli%2C+Tom%3BLockett%2C+Stephen+J&rft.aulast=Gudla&rft.aufirst=Prabhakar&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two and Three Dimensional Segmentation of Whole Cells and Cell Nuclei in Tissue T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40060045; 4219844 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Mccullough, Dean P AU - Baggett, Daniel AU - Lockett, Stephen J Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Segmentation KW - Nuclei UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Two+and+Three+Dimensional+Segmentation+of+Whole+Cells+and+Cell+Nuclei+in+Tissue&rft.au=Mccullough%2C+Dean+P%3BBaggett%2C+Daniel%3BLockett%2C+Stephen+J&rft.aulast=Mccullough&rft.aufirst=Dean&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of T Cell Responses from Two Vaccine Protocols using Multifunctional Profiling T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40058986; 4220192 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Lamoreaux, Laurie AU - Perfetto, Stephen AU - Roederer, Mario AU - Koup, Richard Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Vaccines KW - Lymphocytes T KW - Profiling KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40058986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Comparison+of+T+Cell+Responses+from+Two+Vaccine+Protocols+using+Multifunctional+Profiling&rft.au=Lamoreaux%2C+Laurie%3BPerfetto%2C+Stephen%3BRoederer%2C+Mario%3BKoup%2C+Richard&rft.aulast=Lamoreaux&rft.aufirst=Laurie&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Hoechst Side Population (SP) Cells in Mouse Bone Marrow using Low-Power UV Sources T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40018111; 4220054 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Telford, William G AU - Frolova, Ella G AU - Cabana, Raquel AU - Thomas, Richard A AU - Krishan, Awtar Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Bone marrow KW - Substance P KW - U.V. radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40018111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Analysis+of+Hoechst+Side+Population+%28SP%29+Cells+in+Mouse+Bone+Marrow+using+Low-Power+UV+Sources&rft.au=Telford%2C+William+G%3BFrolova%2C+Ella+G%3BCabana%2C+Raquel%3BThomas%2C+Richard+A%3BKrishan%2C+Awtar&rft.aulast=Telford&rft.aufirst=William&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Analysis of Multiple Caspase Activities in Mouse T Lymphocytes by Flow Cytometry T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 40009628; 4219890 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Telford, William G AU - Packard, Beverly Z AU - Komoriya, Akira Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Lymphocytes KW - Flow cytometry KW - Caspase KW - Lymphocytes T UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Simultaneous+Analysis+of+Multiple+Caspase+Activities+in+Mouse+T+Lymphocytes+by+Flow+Cytometry&rft.au=Telford%2C+William+G%3BPackard%2C+Beverly+Z%3BKomoriya%2C+Akira&rft.aulast=Telford&rft.aufirst=William&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Ordering of the Function of Caspase 3 and 6 by Simultaneous Measurement of the Activities of Two Caspases in Living Cells with a Novel Dual Fret Indicator Probe T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 39985779; 4219943 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Wu, Xiaoli AU - Simone, James AU - He, Liusheng Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Probes KW - Fluorescence resonance energy transfer KW - Caspase-3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Molecular+Ordering+of+the+Function+of+Caspase+3+and+6+by+Simultaneous+Measurement+of+the+Activities+of+Two+Caspases+in+Living+Cells+with+a+Novel+Dual+Fret+Indicator+Probe&rft.au=Wu%2C+Xiaoli%3BSimone%2C+James%3BHe%2C+Liusheng&rft.aulast=Wu&rft.aufirst=Xiaoli&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amine Reactive Dyes: An Effective Tool to Discriminate Live and Dead Cells in Polychromatic Flow Cytometry T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 39964062; 4220207 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Perfetto, Stephen AU - Chattopadhyay, Pratip K AU - Lamoreaux, Laurie AU - Nguyen, Richard AU - Ambrozak, David AU - Richard, Koup A AU - Roederer, Mario Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Dyes KW - Amines KW - Flow cytometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Amine+Reactive+Dyes%3A+An+Effective+Tool+to+Discriminate+Live+and+Dead+Cells+in+Polychromatic+Flow+Cytometry&rft.au=Perfetto%2C+Stephen%3BChattopadhyay%2C+Pratip+K%3BLamoreaux%2C+Laurie%3BNguyen%2C+Richard%3BAmbrozak%2C+David%3BRichard%2C+Koup+A%3BRoederer%2C+Mario&rft.aulast=Perfetto&rft.aufirst=Stephen&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiparameter Flow Cytometric Assays for the Study of Apoptosis T2 - XXXIII International Congress of the International Society for Analytical Cytology AN - 39949891; 4219972 JF - XXXIII International Congress of the International Society for Analytical Cytology AU - Bortner, Carl AU - Sifre, Maria AU - Cidlowski, John Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.atitle=Multiparameter+Flow+Cytometric+Assays+for+the+Study+of+Apoptosis&rft.au=Bortner%2C+Carl%3BSifre%2C+Maria%3BCidlowski%2C+John&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2006-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIII+International+Congress+of+the+International+Society+for+Analytical+Cytology&rft.issn=&rft_id=info:doi/ L2 - http://www.isac2006.com/images/stories/program/isac_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. AN - 67995472; 16713580 AB - S(N)1-type alkylating agents that produce cytotoxic O(6)-methyl-G (O(6)-meG) DNA adducts induce cell cycle arrest and apoptosis in a manner requiring the DNA mismatch repair (MMR) proteins MutSalpha and MutLalpha. Here, we show that checkpoint signaling in response to DNA methylation occurs during S phase and requires DNA replication that gives rise to O(6)-meG/T mispairs. DNA binding studies reveal that MutSalpha specifically recognizes O(6)-meG/T mispairs, but not O(6)-meG/C. In an in vitro assay, ATR-ATRIP, but not RPA, is preferentially recruited to O(6)-meG/T mismatches in a MutSalpha- and MutLalpha-dependent manner. Furthermore, ATR kinase is activated to phosphorylate Chk1 in the presence of O(6)-meG/T mispairs and MMR proteins. These results suggest that MMR proteins can act as direct sensors of methylation damage and help recruit ATR-ATRIP to sites of cytotoxic O(6)-meG adducts to initiate ATR checkpoint signaling. JF - Molecular cell AU - Yoshioka, Ken-ichi AU - Yoshioka, Yoshiko AU - Hsieh, Peggy AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/05/19/ PY - 2006 DA - 2006 May 19 SP - 501 EP - 510 VL - 22 IS - 4 SN - 1097-2765, 1097-2765 KW - ATRIP protein, human KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Carrier Proteins KW - Cell Cycle Proteins KW - DNA Adducts KW - DNA-Binding Proteins KW - Nuclear Proteins KW - Phosphoproteins KW - Guanine KW - 5Z93L87A1R KW - DNA KW - 9007-49-2 KW - O-(6)-methylguanine KW - 9B710FV2AE KW - ATR protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - Exodeoxyribonucleases KW - EC 3.1.- KW - three prime repair exonuclease 1 KW - EC 3.1.16.- KW - MutS DNA Mismatch-Binding Protein KW - EC 3.6.1.3 KW - Index Medicus KW - Animals KW - Carrier Proteins -- metabolism KW - HeLa Cells KW - DNA Damage KW - Humans KW - DNA -- metabolism KW - S Phase KW - Mice KW - Exodeoxyribonucleases -- metabolism KW - Base Sequence KW - Base Pair Mismatch KW - DNA -- genetics KW - Enzyme Activation -- drug effects KW - Nuclear Proteins -- metabolism KW - Signal Transduction KW - Cell Line KW - Phosphoproteins -- metabolism KW - MutS DNA Mismatch-Binding Protein -- metabolism KW - DNA Repair -- physiology KW - DNA Adducts -- toxicity KW - Protein-Serine-Threonine Kinases -- metabolism KW - Guanine -- analogs & derivatives KW - Guanine -- metabolism KW - DNA Adducts -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67995472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=ATR+kinase+activation+mediated+by+MutSalpha+and+MutLalpha+in+response+to+cytotoxic+O6-methylguanine+adducts.&rft.au=Yoshioka%2C+Ken-ichi%3BYoshioka%2C+Yoshiko%3BHsieh%2C+Peggy&rft.aulast=Yoshioka&rft.aufirst=Ken-ichi&rft.date=2006-05-19&rft.volume=22&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Exp Cell Res. 1971 Sep;68(1):163-8 [5165443] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5837-41 [2116007] J Biol Chem. 1991 Feb 25;266(6):3744-51 [1995629] Biochemistry. 1991 Dec 10;30(49):11595-9 [1747377] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6424-8 [8341649] Carcinogenesis. 1994 Oct;15(10):2189-94 [7955052] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6443-7 [8692834] Carcinogenesis. 1999 Mar;20(3):373-82 [10190549] Mol Biol Cell. 2005 Mar;16(3):1513-26 [15647386] Mol Biol Cell. 2005 May;16(5):2372-81 [15743907] Annu Rev Biochem. 2005;74:681-710 [15952900] Curr Biol. 2005 Aug 9;15(15):1395-400 [16085492] J Biol Chem. 2005 Nov 18;280(46):38355-64 [16186122] Cell. 2006 Mar 10;124(5):943-55 [16530042] Nature. 2006 Mar 30;440(7084):631-6 [16429126] Genes Dev. 2004 Jun 1;18(11):1331-44 [15175264] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12384-8 [10535931] Nat Med. 1999 Nov;5(11):1239-41 [10545986] Nat Genet. 2000 Jan;24(1):53-6 [10615127] Oncol Res. 1999;11(9):393-400 [10821533] J Biol Chem. 2000 Sep 8;275(36):27851-7 [10878012] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9092-7 [11481475] Science. 2001 Nov 23;294(5547):1713-6 [11721054] Carcinogenesis. 2001 Dec;22(12):1931-7 [11751422] J Biol Chem. 2002 Jun 14;277(24):21801-9 [11897781] J Biol Chem. 2002 Jul 26;277(30):27088-93 [12015327] Nat Genet. 2003 Jan;33(1):80-4 [12447371] EMBO J. 2003 May 1;22(9):2245-54 [12727890] Science. 2003 Jun 6;300(5625):1542-8 [12791985] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Annu Rev Microbiol. 2003;57:579-608 [14527292] Mol Cell. 2003 Nov;12(5):1077-86 [14636568] Cancer Res. 2003 Dec 1;63(23):8158-66 [14678970] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92 [14657349] Oncogene. 2004 Jan 8;23(1):260-6 [14712231] Mol Cell Biol. 2004 Feb;24(3):1292-300 [14729973] Cancer Res. 2004 Jan 15;64(2):517-22 [14744764] J Biol Chem. 2004 Apr 2;279(14):13346-53 [14724280] Cytogenet Genome Res. 2004;104(1-4):77-86 [15162018] Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9315-20 [15199178] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):883-7 [15279773] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):901-8 [15279775] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1091-101 [15279797] J Biol Chem. 2004 Aug 6;279(32):34010-4 [15197179] Cancer Cell. 2004 Aug;6(2):139-50 [15324697] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4639-43 [6308634] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The promyelocytic leukemia protein stimulates SUMO conjugation in yeast. AN - 67984197; 16501610 AB - The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its behavior and capacity to recruit other proteins to PML nuclear bodies (PML-NBs). In the NB4 cell line, which was derived from an APL patient and expresses PML:RARalpha, we observed a retinoic acid-dependent change in the modification of specific proteins by SUMO-1. To dissect the interaction of PML with the SUMO-1 modification pathway, we used the budding yeast Saccharomyces cerevisiae as a model system through expression of PML and human SUMO-1 (hSUMO-1). We found that PML stimulated hSUMO-1 modification in yeast, in a manner that was dependent upon PML's RING-finger domain. PML:RARalpha also stimulated hSUMO-1 conjugation in yeast. Interestingly, however, PML and PML:RARalpha differentially complemented yeast Smt3p conjugation pathway mutants. These findings point toward a potential function of PML and PML:RARalpha as SUMO E3 enzymes or E3 regulators, and suggest that fusion of RARalpha to PML may affect this activity. JF - Oncogene AU - Quimby, B B AU - Yong-Gonzalez, V AU - Anan, T AU - Strunnikov, A V AU - Dasso, M AD - Section on Cell Cycle Regulation, Laboratory of Gene Regulation and Development, NICHD/NIH, Bethesda, MD 20892, USA. Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 SP - 2999 EP - 3005 VL - 25 IS - 21 SN - 0950-9232, 0950-9232 KW - CDC11 protein, S cerevisiae KW - 0 KW - Cell Cycle Proteins KW - Cytoskeletal Proteins KW - Multiprotein Complexes KW - Neoplasm Proteins KW - Nuclear Proteins KW - Oncogene Proteins, Fusion KW - Promyelocytic Leukemia Protein KW - Recombinant Fusion Proteins KW - Repressor Proteins KW - SMT3 protein, S cerevisiae KW - SUMO-1 Protein KW - SUMO1 protein, human KW - Saccharomyces cerevisiae Proteins KW - Siz2 protein, S cerevisiae KW - Small Ubiquitin-Related Modifier Proteins KW - Transcription Factors KW - Tumor Suppressor Proteins KW - promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein KW - PML protein, human KW - 143220-95-5 KW - Tretinoin KW - 5688UTC01R KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - Siz1 protein, S cerevisiae KW - EC 6.3.2.- KW - Nocodazole KW - SH1WY3R615 KW - Index Medicus KW - Tretinoin -- pharmacology KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Humans KW - Leukemia, Promyelocytic, Acute -- genetics KW - Leukemia, Promyelocytic, Acute -- pathology KW - Nocodazole -- pharmacology KW - Recombinant Fusion Proteins -- physiology KW - Mutagenesis, Site-Directed KW - Multiprotein Complexes -- biosynthesis KW - Saccharomyces cerevisiae -- metabolism KW - Leukemia, Promyelocytic, Acute -- metabolism KW - Genetic Complementation Test KW - Cytoskeletal Proteins -- metabolism KW - Amino Acid Substitution KW - Saccharomyces cerevisiae Proteins -- physiology KW - Repressor Proteins -- genetics KW - Cell Cycle Proteins -- metabolism KW - Transfection KW - Repressor Proteins -- physiology KW - Ubiquitin-Protein Ligases -- metabolism KW - Cell Line, Tumor -- drug effects KW - Protein Structure, Tertiary KW - Species Specificity KW - Small Ubiquitin-Related Modifier Proteins -- genetics KW - Transcription Factors -- physiology KW - Oncogene Proteins, Fusion -- physiology KW - Nuclear Proteins -- genetics KW - Small Ubiquitin-Related Modifier Proteins -- metabolism KW - Neoplasm Proteins -- physiology KW - Tumor Suppressor Proteins -- physiology KW - Oncogene Proteins, Fusion -- genetics KW - Neoplasm Proteins -- genetics KW - Tumor Suppressor Proteins -- genetics KW - Transcription Factors -- genetics KW - Nuclear Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67984197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+promyelocytic+leukemia+protein+stimulates+SUMO+conjugation+in+yeast.&rft.au=Quimby%2C+B+B%3BYong-Gonzalez%2C+V%3BAnan%2C+T%3BStrunnikov%2C+A+V%3BDasso%2C+M&rft.aulast=Quimby&rft.aufirst=B&rft.date=2006-05-18&rft.volume=25&rft.issue=21&rft.spage=2999&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Noradrenergic Mechanisms in Panic Disorder: Behavioral, Autonomic, and Neurophysiological Correlates of a Yohimbine Challenge T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40138725; 4278692 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Carlson, Paul J AU - Neumeister, Alexander AU - Geraci, Marilla AU - Kaplan, Johanna AU - Nugent, Allison AU - Luckenbaugh, David AU - Pine, Daniel AU - Charney, Dennis S AU - Drevets, Wayne C Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Yohimbine KW - Autonomic nervous system KW - Norepinephrine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40138725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Noradrenergic+Mechanisms+in+Panic+Disorder%3A+Behavioral%2C+Autonomic%2C+and+Neurophysiological+Correlates+of+a+Yohimbine+Challenge&rft.au=Carlson%2C+Paul+J%3BNeumeister%2C+Alexander%3BGeraci%2C+Marilla%3BKaplan%2C+Johanna%3BNugent%2C+Allison%3BLuckenbaugh%2C+David%3BPine%2C+Daniel%3BCharney%2C+Dennis+S%3BDrevets%2C+Wayne+C&rft.aulast=Carlson&rft.aufirst=Paul&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PET Imaging of cAMP Phosphodiesterase4 with R-[11C]Rolipram T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40137548; 4279010 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Innis, Robert B AU - Fujita, Masahiro Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Cyclic AMP KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40137548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=PET+Imaging+of+cAMP+Phosphodiesterase4+with+R-%5B11C%5DRolipram&rft.au=Innis%2C+Robert+B%3BFujita%2C+Masahiro&rft.aulast=Innis&rft.aufirst=Robert&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - shRNA-Mediated Silencing of Catechol-O-Methyltransferase in Stable Cell Lines T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40132589; 4278661 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Song, Jian AU - Chen, J AU - Du, J. AU - Liu, G AU - Lipska, B K AU - Weinberger, D R Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Catechol O-methyltransferase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=shRNA-Mediated+Silencing+of+Catechol-O-Methyltransferase+in+Stable+Cell+Lines&rft.au=Song%2C+Jian%3BChen%2C+J%3BDu%2C+J.%3BLiu%2C+G%3BLipska%2C+B+K%3BWeinberger%2C+D+R&rft.aulast=Song&rft.aufirst=Jian&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucocorticoid Receptors (GR) Trafficking into Mitochondria: The Role in Regulating Mitochondrial Function under Chronic Stress T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40132452; 4278594 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Du, Jing AU - Wei, Yanling AU - Wang, Yun AU - Falke, Cynthia AU - Engle, Sharon AU - Chen, James AU - Zhou, Rulun AU - Chen, Jingshan AU - Yuan, Peixiong AU - Manji, Husseini Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Stress KW - Mitochondria KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Glucocorticoid+Receptors+%28GR%29+Trafficking+into+Mitochondria%3A+The+Role+in+Regulating+Mitochondrial+Function+under+Chronic+Stress&rft.au=Du%2C+Jing%3BWei%2C+Yanling%3BWang%2C+Yun%3BFalke%2C+Cynthia%3BEngle%2C+Sharon%3BChen%2C+James%3BZhou%2C+Rulun%3BChen%2C+Jingshan%3BYuan%2C+Peixiong%3BManji%2C+Husseini&rft.aulast=Du&rft.aufirst=Jing&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation by Lithium of Amphetamine-Induced Behaviors: Relevance of b-Catenin T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40132390; 4278577 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - O'Donnell, Kelley C AU - Einat, Haim AU - Picchini, Alyssa M AU - Schloesser, Robert AU - Manji, Husseini K AU - Gould, Todd D Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Lithium KW - Catenin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Modulation+by+Lithium+of+Amphetamine-Induced+Behaviors%3A+Relevance+of+b-Catenin&rft.au=O%27Donnell%2C+Kelley+C%3BEinat%2C+Haim%3BPicchini%2C+Alyssa+M%3BSchloesser%2C+Robert%3BManji%2C+Husseini+K%3BGould%2C+Todd+D&rft.aulast=O%27Donnell&rft.aufirst=Kelley&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurosteroids in Seizure Disorders and Depression and the Development of Neurosteroid Analogs T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40123200; 4279025 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Rogawski, Michael A Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Depression KW - Neurosteroids KW - Seizures KW - Analogs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Neurosteroids+in+Seizure+Disorders+and+Depression+and+the+Development+of+Neurosteroid+Analogs&rft.au=Rogawski%2C+Michael+A&rft.aulast=Rogawski&rft.aufirst=Michael&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Candidate Gene Association Study of Outcome after Citalopram Treatment T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40123141; 4279001 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - McMahon, Francis J Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Citalopram UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=A+Candidate+Gene+Association+Study+of+Outcome+after+Citalopram+Treatment&rft.au=McMahon%2C+Francis+J&rft.aulast=McMahon&rft.aufirst=Francis&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of the Interaction between the Serotonin Transporter Gene Promoter Polymorphism (rh5-HTTLPR) and Early Adversity in Rhesus Macaques T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40123104; 4278984 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Barr, Christina S AU - Lopez, Juan F AU - Thompson, Robert AU - Higley, James Dee Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Serotonin transporter KW - Gene polymorphism KW - Promoters KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Studies+of+the+Interaction+between+the+Serotonin+Transporter+Gene+Promoter+Polymorphism+%28rh5-HTTLPR%29+and+Early+Adversity+in+Rhesus+Macaques&rft.au=Barr%2C+Christina+S%3BLopez%2C+Juan+F%3BThompson%2C+Robert%3BHigley%2C+James+Dee&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DISC1: Three Distinct Pools and their Implication in Major Mental Illnesses T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40123067; 4278981 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Lipska, Barbara K Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40123067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=DISC1%3A+Three+Distinct+Pools+and+their+Implication+in+Major+Mental+Illnesses&rft.au=Lipska%2C+Barbara+K&rft.aulast=Lipska&rft.aufirst=Barbara&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between ESR1 Genetic Variation and ERa mRNA Expression in Patients with Schizophrenia T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40122840; 4278874 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Ward, Sarah E AU - Perlman, William R AU - Miranda-Angulo, Ana L AU - Kleinman, Joel E AU - Weickert, Cynthia Shannon Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Gene expression KW - Schizophrenia KW - Mental disorders KW - Genetic diversity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40122840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Association+between+ESR1+Genetic+Variation+and+ERa+mRNA+Expression+in+Patients+with+Schizophrenia&rft.au=Ward%2C+Sarah+E%3BPerlman%2C+William+R%3BMiranda-Angulo%2C+Ana+L%3BKleinman%2C+Joel+E%3BWeickert%2C+Cynthia+Shannon&rft.aulast=Ward&rft.aufirst=Sarah&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further Evidence for Association of Serotonin Transporter Gene with Obsessive-Compulsive Disorder: Role of the 3 Region T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40122791; 4278864 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Hu, Xianzhang AU - Zhou, Zhi-Feng Zhou AU - Lipsky, Robert H AU - Greenberg, Benjamin D AU - Richter, Margaret A AU - Kennedy, James L AU - Murphy, Dennis AU - Goldman, David Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Obsessive compulsive disorder KW - Serotonin transporter UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40122791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Further+Evidence+for+Association+of+Serotonin+Transporter+Gene+with+Obsessive-Compulsive+Disorder%3A+Role+of+the+3+Region&rft.au=Hu%2C+Xianzhang%3BZhou%2C+Zhi-Feng+Zhou%3BLipsky%2C+Robert+H%3BGreenberg%2C+Benjamin+D%3BRichter%2C+Margaret+A%3BKennedy%2C+James+L%3BMurphy%2C+Dennis%3BGoldman%2C+David&rft.aulast=Hu&rft.aufirst=Xianzhang&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysbindin: Relationship to Cognitive Factors and IQ T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40115068; 4279018 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Weinberger, Daniel R AU - Goldberg, Terry AU - Egan, Michael AU - Callicott, Joe AU - Straub, Richard Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40115068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Dysbindin%3A+Relationship+to+Cognitive+Factors+and+IQ&rft.au=Weinberger%2C+Daniel+R%3BGoldberg%2C+Terry%3BEgan%2C+Michael%3BCallicott%2C+Joe%3BStraub%2C+Richard&rft.aulast=Weinberger&rft.aufirst=Daniel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Genetics and Schizophrenia Susceptibility Genes T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114714; 4278963 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Weinberger, Daniel R Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Genetics KW - Schizophrenia KW - Mental disorders KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Cognitive+Genetics+and+Schizophrenia+Susceptibility+Genes&rft.au=Weinberger%2C+Daniel+R&rft.aulast=Weinberger&rft.aufirst=Daniel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COMT: Contrasting Mechanisms for Addictions Risk T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114428; 4279032 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Goldman, David AU - Schwartz, Lori AU - Albaugh, Bernard AU - Virkkunen, Matti AU - Enoch, Mary-Anne Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=COMT%3A+Contrasting+Mechanisms+for+Addictions+Risk&rft.au=Goldman%2C+David%3BSchwartz%2C+Lori%3BAlbaugh%2C+Bernard%3BVirkkunen%2C+Matti%3BEnoch%2C+Mary-Anne&rft.aulast=Goldman&rft.aufirst=David&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diffusion Tensor Imaging (DTI) Tractography in Williams Syndrome (WS): Preliminary Findings T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114418; 4278876 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Grodofsky, Sam R AU - Marenco, Stefano AU - Siuta, Mike AU - Kippenhan, S AU - Kohn, P AU - Mervis, C B AU - Morris, C A AU - Pierpaoli, C AU - Meyer-Lindenberg, A AU - Berman, K F Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Diffusion KW - Magnetic resonance imaging KW - Williams syndrome KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Diffusion+Tensor+Imaging+%28DTI%29+Tractography+in+Williams+Syndrome+%28WS%29%3A+Preliminary+Findings&rft.au=Grodofsky%2C+Sam+R%3BMarenco%2C+Stefano%3BSiuta%2C+Mike%3BKippenhan%2C+S%3BKohn%2C+P%3BMervis%2C+C+B%3BMorris%2C+C+A%3BPierpaoli%2C+C%3BMeyer-Lindenberg%2C+A%3BBerman%2C+K+F&rft.aulast=Grodofsky&rft.aufirst=Sam&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI Studies of Attention Dysfunction in Pediatric Anxiety Disorders T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114395; 4279019 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Pine, Daniel Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Anxiety KW - Pediatrics KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=fMRI+Studies+of+Attention+Dysfunction+in+Pediatric+Anxiety+Disorders&rft.au=Pine%2C+Daniel&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased Bone Mineral Density in Major Depressive Disorder: When Does it Occur? T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114195; 4278745 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Kling, Mitchel A AU - Yasuhara, Kento AU - Martinez, Pedro E AU - Ronsaville, Donna S AU - Gold, Philip W Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Bone mineral density UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Decreased+Bone+Mineral+Density+in+Major+Depressive+Disorder%3A+When+Does+it+Occur%3F&rft.au=Kling%2C+Mitchel+A%3BYasuhara%2C+Kento%3BMartinez%2C+Pedro+E%3BRonsaville%2C+Donna+S%3BGold%2C+Philip+W&rft.aulast=Kling&rft.aufirst=Mitchel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Linkage of Gain-of-Function Serotonin Transporter Alleles to Obsessive Compulsive Disorder T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114121; 4278983 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Goldman, David AU - Hu, Xianzhang AU - Kennedy, James AU - Murphy, Dennis Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Obsessive compulsive disorder KW - Serotonin transporter KW - Allelles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Linkage+of+Gain-of-Function+Serotonin+Transporter+Alleles+to+Obsessive+Compulsive+Disorder&rft.au=Goldman%2C+David%3BHu%2C+Xianzhang%3BKennedy%2C+James%3BMurphy%2C+Dennis&rft.aulast=Goldman&rft.aufirst=David&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecules Interacting with DISC1 are Differentially Expressed in Schizophrenia and Regulated by SNPs Associated with the Disease T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40114097; 4278982 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Lipska, Barbara K Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Schizophrenia KW - Single-nucleotide polymorphism KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40114097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Molecules+Interacting+with+DISC1+are+Differentially+Expressed+in+Schizophrenia+and+Regulated+by+SNPs+Associated+with+the+Disease&rft.au=Lipska%2C+Barbara+K&rft.aulast=Lipska&rft.aufirst=Barbara&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitochondria Play an Integral Role in the Treatment of Bipolar Disorder: Implications for the Development of Novel Therapeutics T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40113120; 4278955 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Manji, Husseini Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Mitochondria KW - Drug development KW - Bipolar disorder UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40113120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Mitochondria+Play+an+Integral+Role+in+the+Treatment+of+Bipolar+Disorder%3A+Implications+for+the+Development+of+Novel+Therapeutics&rft.au=Manji%2C+Husseini&rft.aulast=Manji&rft.aufirst=Husseini&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Evidence that NMDA Antagonism Induces Rapid and Sustained Antidepressant Effects T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40112670; 4278249 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Maeng, Sungho AU - Creson, Thomas AU - Gould, Todd AU - Zarate, Carlos AU - Chen, Guang AU - Manji, Husseini K Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Antidepressants KW - Antagonism KW - N-Methyl-D-aspartic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40112670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Preclinical+Evidence+that+NMDA+Antagonism+Induces+Rapid+and+Sustained+Antidepressant+Effects&rft.au=Maeng%2C+Sungho%3BCreson%2C+Thomas%3BGould%2C+Todd%3BZarate%2C+Carlos%3BChen%2C+Guang%3BManji%2C+Husseini+K&rft.aulast=Maeng&rft.aufirst=Sungho&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Ability to Regulate Emotionally-Potentiated Startle to Unpleasant Pictures is Moderated by Levels of State and Trait Anxiety T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40112658; 4278843 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Lissek, Shmuel AU - McDowell, Dana J AU - Baas, Johanna M.P. AU - Cornwell, Brian R AU - Pine, Daniel S AU - Grillon, Christian Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Anxiety KW - Emotions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40112658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=The+Ability+to+Regulate+Emotionally-Potentiated+Startle+to+Unpleasant+Pictures+is+Moderated+by+Levels+of+State+and+Trait+Anxiety&rft.au=Lissek%2C+Shmuel%3BMcDowell%2C+Dana+J%3BBaas%2C+Johanna+M.P.%3BCornwell%2C+Brian+R%3BPine%2C+Daniel+S%3BGrillon%2C+Christian&rft.aulast=Lissek&rft.aufirst=Shmuel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Antidepressant Effects and Cognitive Impact of Antimuscarinic Agents in Mood Disorders T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40112599; 4278237 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Furey, Maura AU - Drevets, Wayne Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Antidepressants KW - Mood KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40112599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=The+Antidepressant+Effects+and+Cognitive+Impact+of+Antimuscarinic+Agents+in+Mood+Disorders&rft.au=Furey%2C+Maura%3BDrevets%2C+Wayne&rft.aulast=Furey&rft.aufirst=Maura&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fear Inhibition in Rhesus Monkeys: Evidence for an Objective Measure T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40112329; 4278722 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Winslow, James T AU - Noble, Pamela L AU - Hertzberg, Kevin AU - Myers, Karen M AU - Davis, Michael Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Fear KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40112329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Fear+Inhibition+in+Rhesus+Monkeys%3A+Evidence+for+an+Objective+Measure&rft.au=Winslow%2C+James+T%3BNoble%2C+Pamela+L%3BHertzberg%2C+Kevin%3BMyers%2C+Karen+M%3BDavis%2C+Michael&rft.aulast=Winslow&rft.aufirst=James&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased Serum Transferrin (TRF), a Negative Acute Phase Protein, in Unmedicated Remitted Major Depressive Disorder (MDD) Patients: Further Evidence for a Persistent Pro-Inflammatory State in MDD T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40111404; 4278636 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Kling, Mitchel A AU - Csako, Gyorgy AU - Alesci, Salvatore AU - Luckenbaugh, David A AU - Costello, Rene AU - Bonne, Omer AU - Manji, Husseini AU - Charney, Dennis S AU - Gold, Philip W AU - Neumeister, Alexander Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Transferrin KW - Acute phase substances KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40111404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Decreased+Serum+Transferrin+%28TRF%29%2C+a+Negative+Acute+Phase+Protein%2C+in+Unmedicated+Remitted+Major+Depressive+Disorder+%28MDD%29+Patients%3A+Further+Evidence+for+a+Persistent+Pro-Inflammatory+State+in+MDD&rft.au=Kling%2C+Mitchel+A%3BCsako%2C+Gyorgy%3BAlesci%2C+Salvatore%3BLuckenbaugh%2C+David+A%3BCostello%2C+Rene%3BBonne%2C+Omer%3BManji%2C+Husseini%3BCharney%2C+Dennis+S%3BGold%2C+Philip+W%3BNeumeister%2C+Alexander&rft.aulast=Kling&rft.aufirst=Mitchel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Amygdala Activation during Passive Avoidance Learning in Post-Traumatic Stress Disorder T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40102974; 4278243 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Vythilingam, Meena Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Stress KW - Post-traumatic stress disorder KW - Avoidance learning KW - Amygdala KW - Avoidance reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Enhanced+Amygdala+Activation+during+Passive+Avoidance+Learning+in+Post-Traumatic+Stress+Disorder&rft.au=Vythilingam%2C+Meena&rft.aulast=Vythilingam&rft.aufirst=Meena&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SOD2 Haplotype Predicts MnSOD Expression Level and Increases Risk of Schizophrenia Three-Fold T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40102556; 4278421 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Buzas, Beata AU - Malhotra, Anil K AU - Lencz, Todd AU - Hodgkinson, Colin A AU - DeRosse, Pamela AU - Kane, John AU - Caycedo, Daniel AU - Max, Mitchell M AU - Manji, Husseini K AU - Goldman, David Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Superoxide dismutase KW - Schizophrenia KW - Mental disorders KW - Haplotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=SOD2+Haplotype+Predicts+MnSOD+Expression+Level+and+Increases+Risk+of+Schizophrenia+Three-Fold&rft.au=Buzas%2C+Beata%3BMalhotra%2C+Anil+K%3BLencz%2C+Todd%3BHodgkinson%2C+Colin+A%3BDeRosse%2C+Pamela%3BKane%2C+John%3BCaycedo%2C+Daniel%3BMax%2C+Mitchell+M%3BManji%2C+Husseini+K%3BGoldman%2C+David&rft.aulast=Buzas&rft.aufirst=Beata&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid and Relatively Sustained Antidepressant Effects with a Single Intravenous Dose of an NMDA Antagonist in Treatment-Resistant Major Depression: A Double-Blind, Placebo-Controlled Trial T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40102289; 4278339 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Zarate, Carlos Alberto AU - Singh, Jaskaran AU - Carlson, Paul J AU - Brutsche, Nancy AU - Ameli, Rezvan AU - Luckenbaugh, David AU - Charney, Dennis S AU - Manji, Husseini K Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Antidepressants KW - Depression KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Intravenous administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Rapid+and+Relatively+Sustained+Antidepressant+Effects+with+a+Single+Intravenous+Dose+of+an+NMDA+Antagonist+in+Treatment-Resistant+Major+Depression%3A+A+Double-Blind%2C+Placebo-Controlled+Trial&rft.au=Zarate%2C+Carlos+Alberto%3BSingh%2C+Jaskaran%3BCarlson%2C+Paul+J%3BBrutsche%2C+Nancy%3BAmeli%2C+Rezvan%3BLuckenbaugh%2C+David%3BCharney%2C+Dennis+S%3BManji%2C+Husseini+K&rft.aulast=Zarate&rft.aufirst=Carlos&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurosteroids in the Pathogenesis and Treatment of Affective Disorders T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40083022; 4279023 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Rubinow, David R AU - Schmidt, Peter J AU - Bloch, Miki AU - Daly, Robert C AU - Khine, Khursheed AU - Smith, Mark J Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Affective disorders KW - Neurosteroids KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40083022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Neurosteroids+in+the+Pathogenesis+and+Treatment+of+Affective+Disorders&rft.au=Rubinow%2C+David+R%3BSchmidt%2C+Peter+J%3BBloch%2C+Miki%3BDaly%2C+Robert+C%3BKhine%2C+Khursheed%3BSmith%2C+Mark+J&rft.aulast=Rubinow&rft.aufirst=David&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inportance of Innovation in Neuroscience Research T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40082941; 4279011 DE: JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Insel, Thomas Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40082941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Inportance+of+Innovation+in+Neuroscience+Research&rft.au=Insel%2C+Thomas&rft.aulast=Insel&rft.aufirst=Thomas&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toward Constructing an Endophenotype Strategy for Bipolar Disorders: Overlap with Schizophrenia T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40082893; 4279004 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Manji, Husseini K AU - Hasler, Gregor AU - Drevets, Wayne C AU - Gould, Todd D AU - Gottesman, Irving I Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Schizophrenia KW - Mental disorders KW - Bipolar disorder UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40082893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Toward+Constructing+an+Endophenotype+Strategy+for+Bipolar+Disorders%3A+Overlap+with+Schizophrenia&rft.au=Manji%2C+Husseini+K%3BHasler%2C+Gregor%3BDrevets%2C+Wayne+C%3BGould%2C+Todd+D%3BGottesman%2C+Irving+I&rft.aulast=Manji&rft.aufirst=Husseini&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging 5-HT1A Receptor in Mood and Anxiety Disorders T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40082726; 4278958 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Drevets, Wayne C Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Anxiety KW - Serotonin S1 receptors KW - Imaging techniques KW - Mood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40082726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Imaging+5-HT1A+Receptor+in+Mood+and+Anxiety+Disorders&rft.au=Drevets%2C+Wayne+C&rft.aulast=Drevets&rft.aufirst=Wayne&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of Anhedonia in Depressed Patients and Healthy Controls: Examining the Validity of a Modified Snaith-Hamilton Pleasure Scale T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40082413; 4278879 DE: JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Gould, Neda F AU - Holmes, Kathleen AU - Luckenbaugh, David A AU - Manji, Husseini K AU - Zarate, Carlos A AU - Ameli, Rezvan Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40082413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Assessment+of+Anhedonia+in+Depressed+Patients+and+Healthy+Controls%3A+Examining+the+Validity+of+a+Modified+Snaith-Hamilton+Pleasure+Scale&rft.au=Gould%2C+Neda+F%3BHolmes%2C+Kathleen%3BLuckenbaugh%2C+David+A%3BManji%2C+Husseini+K%3BZarate%2C+Carlos+A%3BAmeli%2C+Rezvan&rft.aulast=Gould&rft.aufirst=Neda&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lithium and Amphetamine: Endophenotypes, Mouse Strain Differences and Transgenic Models T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40080088; 4278229 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Gould, Todd D Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Lithium KW - Amphetamine KW - Strains UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40080088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Lithium+and+Amphetamine%3A+Endophenotypes%2C+Mouse+Strain+Differences+and+Transgenic+Models&rft.au=Gould%2C+Todd+D&rft.aulast=Gould&rft.aufirst=Todd&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of the Severity Index of Psychosocial and Environmental Stress T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40078600; 4278609 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Moral, Jazmin R AU - Holmes, M Kathleen AU - Cumba, Delia Raquel AU - Luckenbaugh, David A AU - Zarate, Carlos A AU - Manji, Husseini K Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Environmental stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Development+of+the+Severity+Index+of+Psychosocial+and+Environmental+Stress&rft.au=Moral%2C+Jazmin+R%3BHolmes%2C+M+Kathleen%3BCumba%2C+Delia+Raquel%3BLuckenbaugh%2C+David+A%3BZarate%2C+Carlos+A%3BManji%2C+Husseini+K&rft.aulast=Moral&rft.aufirst=Jazmin&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple, Novel Polymorphisms in the Rhesus Macaque DRD4 Gene Promoter are Associated with Impulsive and Aggressive Behavior T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40078258; 4278907 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Newman, Timothy K AU - Barr, Christina S AU - Suomi, Steven J AU - Higley, J Dee AU - Goldman, David Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Aggressive behavior KW - DRD4 gene KW - Promoters KW - Gene polymorphism KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Multiple%2C+Novel+Polymorphisms+in+the+Rhesus+Macaque+DRD4+Gene+Promoter+are+Associated+with+Impulsive+and+Aggressive+Behavior&rft.au=Newman%2C+Timothy+K%3BBarr%2C+Christina+S%3BSuomi%2C+Steven+J%3BHigley%2C+J+Dee%3BGoldman%2C+David&rft.aulast=Newman&rft.aufirst=Timothy&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Amygdala Hyperactivity, and Prefrontal Hypoactivity to Fearful Faces and Severity of Social Anxiety in Social Anxiety Disorder T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40077508; 4278695 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Blair, Karina AU - Shaywitz, Jonathan AU - Geraci, Marilla AU - Vythilingam, Meena AU - Jones, Matthew AU - McCaffrey, Daniel AU - Charney, Dennis S AU - Drevets, Wayne AU - Pine, Daniel AU - Blair, James Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Anxiety KW - Hyperactivity KW - Amygdala UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40077508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Association+between+Amygdala+Hyperactivity%2C+and+Prefrontal+Hypoactivity+to+Fearful+Faces+and+Severity+of+Social+Anxiety+in+Social+Anxiety+Disorder&rft.au=Blair%2C+Karina%3BShaywitz%2C+Jonathan%3BGeraci%2C+Marilla%3BVythilingam%2C+Meena%3BJones%2C+Matthew%3BMcCaffrey%2C+Daniel%3BCharney%2C+Dennis+S%3BDrevets%2C+Wayne%3BPine%2C+Daniel%3BBlair%2C+James&rft.aulast=Blair&rft.aufirst=Karina&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serotonin Transporter Promoter Polymorphism Predicting Increased Transcription is Associated with Tolerability to Citalopram Treatment in the STAR*D Effectiveness Trial T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40076461; 4278254 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Hu, Xian-Zhang AU - Rush, A John AU - Charney, Dennis S AU - Wilson, Alexander F AU - Sorant, Alexa J M AU - Papanicolaou, George J AU - Fava, Maurizio AU - Trivedi, Madhukar H AU - Wisniewski, Steven AU - Laje, Gonzalo AU - Buervenich, Silvia AU - McMahon, Francis J AU - Manji, Husseini AU - Lipsky, Robert H Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Serotonin transporter KW - Citalopram KW - Transcription KW - Gene polymorphism KW - Promoters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40076461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Serotonin+Transporter+Promoter+Polymorphism+Predicting+Increased+Transcription+is+Associated+with+Tolerability+to+Citalopram+Treatment+in+the+STAR*D+Effectiveness+Trial&rft.au=Hu%2C+Xian-Zhang%3BRush%2C+A+John%3BCharney%2C+Dennis+S%3BWilson%2C+Alexander+F%3BSorant%2C+Alexa+J+M%3BPapanicolaou%2C+George+J%3BFava%2C+Maurizio%3BTrivedi%2C+Madhukar+H%3BWisniewski%2C+Steven%3BLaje%2C+Gonzalo%3BBuervenich%2C+Silvia%3BMcMahon%2C+Francis+J%3BManji%2C+Husseini%3BLipsky%2C+Robert+H&rft.aulast=Hu&rft.aufirst=Xian-Zhang&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Socially Relevant Conditioned and Unconditioned Stimuli to Examine the Associative Learning Components of Social Anxiety Disorder T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40074274; 4278592 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Lissek, Shmuel AU - Levenson, Jessica AU - McDowell, Dana J AU - Johnson, Linda L AU - Levine, Jessica AU - Pine, Daniel S AU - Grillon, Christian Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Anxiety KW - Associative learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40074274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Using+Socially+Relevant+Conditioned+and+Unconditioned+Stimuli+to+Examine+the+Associative+Learning+Components+of+Social+Anxiety+Disorder&rft.au=Lissek%2C+Shmuel%3BLevenson%2C+Jessica%3BMcDowell%2C+Dana+J%3BJohnson%2C+Linda+L%3BLevine%2C+Jessica%3BPine%2C+Daniel+S%3BGrillon%2C+Christian&rft.aulast=Lissek&rft.aufirst=Shmuel&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Choose Your Parents Well: Gene X Environment Interactions Leading to Pathological Developmental Pathways T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40073649; 4279031 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Higley, James Dee AU - Barr, Christina AU - Newman, Tim Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Translation KW - Drug abuse KW - Alcoholism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Choose+Your+Parents+Well%3A+Gene+X+Environment+Interactions+Leading+to+Pathological+Developmental+Pathways&rft.au=Higley%2C+James+Dee%3BBarr%2C+Christina%3BNewman%2C+Tim&rft.aulast=Higley&rft.aufirst=James&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated Overnight Plasma Norepinephrine in Actively Depressed Unipolar and Bipolar Patients: Relation to Overnight Dihydroxyphenylglycol (DHPG) T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40072680; 4278891 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Carlson, Paul J AU - Kling, Mitchel A AU - Bain, Earle AU - Alesci, Salvatore AU - Lambert, Gavin AU - Esler, Murray AU - Gold, Philip W AU - Drevets, Wayne C Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Norepinephrine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40072680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Elevated+Overnight+Plasma+Norepinephrine+in+Actively+Depressed+Unipolar+and+Bipolar+Patients%3A+Relation+to+Overnight+Dihydroxyphenylglycol+%28DHPG%29&rft.au=Carlson%2C+Paul+J%3BKling%2C+Mitchel+A%3BBain%2C+Earle%3BAlesci%2C+Salvatore%3BLambert%2C+Gavin%3BEsler%2C+Murray%3BGold%2C+Philip+W%3BDrevets%2C+Wayne+C&rft.aulast=Carlson&rft.aufirst=Paul&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What are the Clinical and Research Implications of the Serotonin Transporter Genotype? T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40055596; 4278272 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Merikangas, Kathleen Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Serotonin transporter KW - Genotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=What+are+the+Clinical+and+Research+Implications+of+the+Serotonin+Transporter+Genotype%3F&rft.au=Merikangas%2C+Kathleen&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Pro-Inflammatory Mechanisms in the Increased Risk for Cardiovascular Disease and Bone Loss in Mood Disorders T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40044731; 4278744 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Alesci, Salvatore AU - Listwak, Samuel J AU - Gold, Philip W Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Bone loss KW - Cardiovascular diseases KW - Mood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40044731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Role+of+Pro-Inflammatory+Mechanisms+in+the+Increased+Risk+for+Cardiovascular+Disease+and+Bone+Loss+in+Mood+Disorders&rft.au=Alesci%2C+Salvatore%3BListwak%2C+Samuel+J%3BGold%2C+Philip+W&rft.aulast=Alesci&rft.aufirst=Salvatore&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PET Radioligands for the 5-HT1A Receptor: Rapid Removal from Brain via P-gp Efflux Pump and Effects of Defluorination T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40019839; 4278957 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Innis, Robert B Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Brain KW - Pumps KW - Serotonin S1 receptors KW - Positron emission tomography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=PET+Radioligands+for+the+5-HT1A+Receptor%3A+Rapid+Removal+from+Brain+via+P-gp+Efflux+Pump+and+Effects+of+Defluorination&rft.au=Innis%2C+Robert+B&rft.aulast=Innis&rft.aufirst=Robert&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transmural Dispersion of Myofiber Mechanics: Implications for Electrical Heterogeneity In Vivo T2 - 27th Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2006) AN - 40073255; 4288669 JF - 27th Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2006) AU - Ashikaga, Hiroshi AU - Coppola, Benjamin A AU - Hopenfeld, Bruce AU - McVeigh, Elliot R AU - Omens, Jeffrey H Y1 - 2006/05/17/ PY - 2006 DA - 2006 May 17 KW - Dispersion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2006%29&rft.atitle=Transmural+Dispersion+of+Myofiber+Mechanics%3A+Implications+for+Electrical+Heterogeneity+In+Vivo&rft.au=Ashikaga%2C+Hiroshi%3BCoppola%2C+Benjamin+A%3BHopenfeld%2C+Bruce%3BMcVeigh%2C+Elliot+R%3BOmens%2C+Jeffrey+H&rft.aulast=Ashikaga&rft.aufirst=Hiroshi&rft.date=2006-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BD805E9 9F%2D0F74%2D4123%2D9F1C%2DDF01D1E52619%7D&AKey=%7BB41FF5AA%2D54D0%2D 4CA8%2D8CE2%2D54F33E1D13F1%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses. AN - 67978502; 16507785 AB - Acute renal failure (ARF) has a high morbidity and mortality. In animal ARF models, effective treatments must be administered before or shortly after the insult, limiting their clinical potential. We used microarrays to identify early biomarkers that distinguish ischemic from nephrotoxic ARF or biomarkers that detect both injury types. We compared rat kidney transcriptomes at 2 and 8 h after ischemia/reperfusion and after mercuric chloride. Quality control and statistical analyses were necessary to normalize microarrays from different lots, eliminate outliers, and exclude unaltered genes. Principal component analysis revealed distinct ischemic and nephrotoxic trajectories and clear array groupings. Therefore, we used supervised analysis, t-tests, and fold changes to compile gene lists for each group, exclusive or nonexclusive, alone or in combination. There was little network connectivity, even in the largest group. Some microarray-identified genes were validated by TaqMan assay, ruling out artifacts. Western blotting confirmed that heme oxygenase-1 (HO-1) and activating transcription factor-3 (ATF3) proteins were upregulated; however, unexpectedly, their localization changed within the kidney. HO-1 staining shifted from cortical (early) to outer stripe of the outer medulla (late), primarily in detaching cells, after mercuric chloride but not ischemia/reperfusion. ATF3 staining was similar, but with additional early transient expression in the outer stripe after ischemia/reperfusion. We conclude that microarray-identified genes must be evaluated not only for protein levels but also for anatomical distribution among different zones, nephron segments, or cell types. Although protein detection reagents are limited, microarray data lay a rich foundation to explore biomarkers, therapeutics, and the pathophysiology of ARF. JF - Physiological genomics AU - Yuen, Peter S T AU - Jo, Sang-Kyung AU - Holly, Mikaela K AU - Hu, Xuzhen AU - Star, Robert A AD - Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1268, USA. py@nih.gov Y1 - 2006/05/16/ PY - 2006 DA - 2006 May 16 SP - 375 EP - 386 VL - 25 IS - 3 KW - Activating Transcription Factor 3 KW - 0 KW - Atf3 protein, rat KW - RNA, Messenger KW - Mercuric Chloride KW - 53GH7MZT1R KW - Heme Oxygenase (Decyclizing) KW - EC 1.14.14.18 KW - Hmox1 protein, rat KW - Index Medicus KW - Animals KW - Activating Transcription Factor 3 -- metabolism KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Heme Oxygenase (Decyclizing) -- genetics KW - Principal Component Analysis KW - Rats KW - Gene Expression Profiling KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Heme Oxygenase (Decyclizing) -- metabolism KW - Gene Expression Regulation KW - Activating Transcription Factor 3 -- genetics KW - Mercuric Chloride -- toxicity KW - Time Factors KW - Immunohistochemistry KW - Male KW - Kidney -- metabolism KW - Ischemia -- complications KW - Acute Kidney Injury -- genetics KW - Kidney -- drug effects KW - Acute Kidney Injury -- etiology KW - Transcription, Genetic KW - Kidney -- blood supply KW - Acute Kidney Injury -- metabolism KW - Ischemia -- metabolism KW - Ischemia -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67978502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+genomics&rft.atitle=Ischemic+and+nephrotoxic+acute+renal+failure+are+distinguished+by+their+broad+transcriptomic+responses.&rft.au=Yuen%2C+Peter+S+T%3BJo%2C+Sang-Kyung%3BHolly%2C+Mikaela+K%3BHu%2C+Xuzhen%3BStar%2C+Robert+A&rft.aulast=Yuen&rft.aufirst=Peter+S&rft.date=2006-05-16&rft.volume=25&rft.issue=3&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Physiological+genomics&rft.issn=1531-2267&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-08 N1 - Date created - 2006-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Kidney Int. 2002 Nov;62(5):1601-10 [12371960] EMBO J. 2002 Oct 1;21(19):5088-96 [12356725] Am J Physiol Renal Physiol. 2003 Apr;284(4):F743-52 [12453873] Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3233-8 [12629205] Kidney Int. 2003 May;63(5):1714-24 [12675847] Kidney Int. 2003 Aug;64(2):480-92 [12846743] J Am Soc Nephrol. 2003 Oct;14(10):2534-43 [14514731] J Biol Chem. 2003 Nov 7;278(45):44312-9 [12952966] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13537-42 [14573703] Curr Biol. 2003 Dec 2;13(23):R925-36 [14654021] Proteomics. 2004 Mar;4(3):609-18 [14997484] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Mol Cell Proteomics. 2004 May;3(5):478-89 [14766929] Kidney Int Suppl. 2004 Oct;(91):S62-6 [15461706] Am J Pathol. 1968 Jun;52(6):1225-77 [5649477] Lab Invest. 1974 Dec;31(6):633-47 [4437137] Virchows Arch B Cell Pathol. 1975 Jul 18;18(3):243-62 [808031] Virchows Arch B Cell Pathol. 1976 Nov 24;22(3):173-96 [827102] Lancet. 1986 Feb 8;1(8476):307-10 [2868172] Toxicol Pathol. 1994 May-Jun;22(3):282-90 [7529424] Am J Physiol. 1997 Feb;272(2 Pt 2):F160-6 [9124391] J Biol Chem. 1997 Aug 8;272(32):19943-50 [9242662] Am J Physiol. 1997 Sep;273(3 Pt 2):F380-5 [9321910] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Kidney Int. 1998 Dec;54(6):1817-31 [9853246] Exp Nephrol. 1999 Jan-Feb;7(1):15-9 [9892809] Oncogene. 1999 Jun 17;18(24):3633-42 [10380885] Gene Expr. 1999;7(4-6):321-35 [10440233] Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2078-84 [10479648] Proteomics. 2005 Apr;5(5):1281-91 [15732136] Lancet. 2005 Apr 2-8;365(9466):1231-8 [15811456] Am J Physiol Renal Physiol. 2003 Jan;284(1):F218-28 [12388413] Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9498-503 [10920185] Kidney Int. 2000 Sep;58(3):1346-53 [10972700] Oncogene. 2000 Nov 9;19(47):5348-58 [11103936] Cell. 2000 Dec 8;103(6):897-907 [11136975] Toxicol Sci. 2001 Oct;63(2):196-207 [11568363] Pharmacogenetics. 2002 Jan;12(1):55-65 [11773865] Biochem Biophys Res Commun. 2002 Mar 8;291(4):787-94 [11866434] Kidney Int. 2002 May;61(5):1646-54 [11967014] J Immunol. 2002 Jul 15;169(2):1007-13 [12097408] Curr Opin Crit Care. 2002 Dec;8(6):526-34 [12454537] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation. AN - 67981938; 16707476 AB - Epidemiologic studies show a positive association between obesity and cancer risk. In addition to increased body adiposity and secretion of fat-derived hormones, obesity is also linked to insulin resistance, type 2 diabetes, and chronic inflammation. We used the fatless A-ZIP/F-1 transgenic mouse to dissociate the relative role of each of these underlying factors in the development of cancer. These mice are unique in that they do not have white fat but do develop type 2 diabetes. In two cancer models, the classic two-stage skin carcinogenesis protocol and the C3(1)/T-Ag transgenic mouse mammary tumor model, A-ZIP/F-1 mice displayed higher tumor incidence, tumor multiplicity, and decreased tumor latency than wild-type mice. We examined circulating levels of adipokines, growth factors, and cytokines. As expected, adipokines (i.e., leptin, adiponectin, and resistin) were undetectable or found at very low levels in the blood of fatless mice. However, insulin, insulin-like growth factor-I, growth hormone, vascular endothelial growth factor, and proinflammatory Th2 cytokines, such as interleukin (IL)-1beta, IL-4, and IL-6, were elevated in A-ZIP/F-1 mice. Additionally, we examined multiple phosphorylated proteins (i.e., protein kinase B/Akt and ErbB2/HER-2 kinase) associated with cancer development. Results show that many of these phosphorylated proteins were activated specifically in the A-ZIP/F-1 skin but not in the wild-type skin. These findings suggest that adipokines are not required for the promotion of tumor development and thus contradict the epidemiologic data linking obesity to carcinogenesis. We postulate that insulin resistance and inflammation are responsible for the positive correlation with cancer observed in A-ZIP/F-1 mice. JF - Cancer research AU - Nunez, Nomeli P AU - Oh, Won-Jun AU - Rozenberg, Julian AU - Perella, Chris AU - Anver, Miriam AU - Barrett, J Carl AU - Perkins, Susan N AU - Berrigan, David AU - Moitra, Jaideep AU - Varticovski, Lyuba AU - Hursting, Stephen D AU - Vinson, Charles AD - Laboratories of Biosystems and Cancer, Metabolism, Human Carcinogenesis and Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 5469 EP - 5476 VL - 66 IS - 10 SN - 0008-5472, 0008-5472 KW - Adiponectin KW - 0 KW - Cytokines KW - Leptin KW - Resistin KW - Tg(AZIP-F)1Vsn protein, mouse KW - Transcription Factors KW - Index Medicus KW - Cytokines -- blood KW - Transcription Factors -- physiology KW - Animals KW - Disease Susceptibility KW - Resistin -- blood KW - Inflammation -- genetics KW - Mice KW - Adipose Tissue -- physiology KW - Mice, Transgenic KW - Transcription Factors -- genetics KW - Insulin Resistance -- physiology KW - Leptin -- blood KW - Adipose Tissue -- metabolism KW - Insulin Resistance -- genetics KW - Inflammation -- metabolism KW - Adiponectin -- blood KW - Female KW - Inflammation -- complications KW - Obesity -- genetics KW - Skin Neoplasms -- etiology KW - Diabetes Mellitus, Type 2 -- complications KW - Mammary Neoplasms, Experimental -- etiology KW - Diabetes Mellitus, Type 2 -- genetics KW - Diabetes Mellitus, Type 2 -- blood KW - Mammary Neoplasms, Experimental -- metabolism KW - Skin Neoplasms -- metabolism KW - Skin Neoplasms -- blood KW - Mammary Neoplasms, Experimental -- blood KW - Obesity -- complications KW - Obesity -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67981938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Accelerated+tumor+formation+in+a+fatless+mouse+with+type+2+diabetes+and+inflammation.&rft.au=Nunez%2C+Nomeli+P%3BOh%2C+Won-Jun%3BRozenberg%2C+Julian%3BPerella%2C+Chris%3BAnver%2C+Miriam%3BBarrett%2C+J+Carl%3BPerkins%2C+Susan+N%3BBerrigan%2C+David%3BMoitra%2C+Jaideep%3BVarticovski%2C+Lyuba%3BHursting%2C+Stephen+D%3BVinson%2C+Charles&rft.aulast=Nunez&rft.aufirst=Nomeli&rft.date=2006-05-15&rft.volume=66&rft.issue=10&rft.spage=5469&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imaging and in vivo quantitation of beta-amyloid: an exemplary biomarker for Alzheimer's disease? AN - 67947835; 16487944 AB - Alzheimer's disease (AD) is characterized pathologically by the presence of beta-amyloid plaques in the brain. A substantial body of research indicates that the presence of increased beta-amyloid peptide (Abeta) is neurotoxic and may initiate the further pathology observed in AD, including neurofibrillary tangles, synaptic loss and dysfunction, and neurodegeneration. The use of brain imaging in patients with or at risk for AD has increased our understanding of the pathophysiology of the disease and may potentially aid in diagnosis. The development of new therapeutics that reduce Abeta in the brain has also indicated a potential use for amyloid imaging in monitoring response to treatment. This review explores the utility of amyloid as a biomarker and the use of positron emission tomography and magnetic resonance imaging in the diagnosis and treatment of AD. JF - Biological psychiatry AU - Nichols, Lisa AU - Pike, Victor W AU - Cai, Lisheng AU - Innis, Robert B AD - Molecular Imaging Branch, National Institutes of Health, Bethesda, Maryland 20892-0135, USA. Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 940 EP - 947 VL - 59 IS - 10 SN - 0006-3223, 0006-3223 KW - Amyloid beta-Peptides KW - 0 KW - Biomarkers KW - Molecular Probes KW - Index Medicus KW - Sensitivity and Specificity KW - Brain Mapping KW - Humans KW - Brain -- pathology KW - Magnetic Resonance Imaging KW - Imaging, Three-Dimensional KW - Positron-Emission Tomography KW - Biomarkers -- analysis KW - Alzheimer Disease -- etiology KW - Amyloid beta-Peptides -- analysis KW - Image Processing, Computer-Assisted KW - Alzheimer Disease -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67947835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Imaging+and+in+vivo+quantitation+of+beta-amyloid%3A+an+exemplary+biomarker+for+Alzheimer%27s+disease%3F&rft.au=Nichols%2C+Lisa%3BPike%2C+Victor+W%3BCai%2C+Lisheng%3BInnis%2C+Robert+B&rft.aulast=Nichols&rft.aufirst=Lisa&rft.date=2006-05-15&rft.volume=59&rft.issue=10&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-02 N1 - Date created - 2006-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dosing cards for treatment of children exposed to weapons of mass destruction. AN - 67937061; 16675651 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Montello, Michael J AU - Tarosky, Matthew AU - Pincock, Laura AU - Montello, Nicole AU - Hess, William Albert AU - Velazquez, Lydia AU - Patel, Arti AU - Krzyworzeka, Julia AU - Hay, Elizabeth AD - National Cancer Institute, 6130 Executive Boulevard, Rockville, MD 20852, USA. montellom@ctep.nci.nih.gov Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 944 EP - 949 VL - 63 IS - 10 SN - 1079-2082, 1079-2082 KW - Antidotes KW - 0 KW - Chemical Warfare Agents KW - Pharmaceutical Preparations KW - Radiation-Protective Agents KW - Index Medicus KW - Radiation-Protective Agents -- therapeutic use KW - Radiation-Protective Agents -- administration & dosage KW - Antidotes -- administration & dosage KW - Humans KW - Antidotes -- therapeutic use KW - Pharmaceutical Preparations -- administration & dosage KW - Chemical Warfare Agents -- poisoning KW - Nuclear Warfare KW - Child UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67937061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Dosing+cards+for+treatment+of+children+exposed+to+weapons+of+mass+destruction.&rft.au=Montello%2C+Michael+J%3BTarosky%2C+Matthew%3BPincock%2C+Laura%3BMontello%2C+Nicole%3BHess%2C+William+Albert%3BVelazquez%2C+Lydia%3BPatel%2C+Arti%3BKrzyworzeka%2C+Julia%3BHay%2C+Elizabeth&rft.aulast=Montello&rft.aufirst=Michael&rft.date=2006-05-15&rft.volume=63&rft.issue=10&rft.spage=944&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-02 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: Evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines AN - 19839944; 6856230 AB - To investigate the kinetic changes in adaptive immunity during experimental Haemophilus influenzae type b (Hib) meningitis, we established a murine meningitis model based on T1/T2 doubly transgenic mice. These mice carry two transgenes that express two distinct cell-surface markers: a human Thy1 transgene (hThy1) under the control of the murine IFN- gamma promoter, and a murine Thy1.1 transgene (mThy1.1) under the control of the murine IL-4 promoter, designated T1 and T2, respectively. Mice infected with Hib displayed severest symptoms and lowest total splenocyte counts on day 3 after infection. Simultaneously, we examined the significantly low percentage of CD19 super(+) B cells, the relatively high level of CD4 super(+) T cells and significantly high percentage of CD8 super(+) T cells in Hib-infected mice. Furthermore, we observed the early induction of both Th1 and Th2 responses, in terms of the augmentation of Th1 cells (IFN- gamma -producing CD4 super(+) T cells) and Th2 cells (IL-4-producing CD4 super(+) T cells) in Hib-infected mice. On day 7 after infection, the Th1 response gradually declined and the Th2 response rather sustained. Two weeks after infection, both Th1 and Th2 cells were barely detectable. Moreover, we demonstrated using an antigen-specific re-stimulation test to analyze the effector function of lymphocyte subsets that CD8 super(+) T cells contributed to more predominantly production of IFN- gamma than CD4 super(+) T cells did; and CD4 super(+) T cells partly contributed to the secretion of IL-4 from flowcytometry of intracellular cytokine staining. Our results support that these transgenic mice provide an available model to dissect the complex kinetic change of adaptive immunity in bacterial infectious diseases. JF - Immunology Letters AU - Chen, S J AU - Liao, CL AU - Hsieh, S L AU - Chu, M L AU - Fang, M C AU - Sytwu, H K AU - Wang, C C AD - Tri-Service General Hospital, 325 Cheng-Kung Road, Section 2, Nei-Hu, Taipei 114, Taiwan, sytwu@ndmctsgh.edu.tw Y1 - 2006/05/15/ PY - 2006 DA - 2006 May 15 SP - 6 EP - 15 PB - Elsevier B.V. VL - 105 IS - 1 SN - 0165-2478, 0165-2478 KW - adaptive immunity KW - interferon gamma KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Interleukin 4 KW - Haemophilus influenzae KW - Lymphocytes B KW - Helper cells KW - Animal models KW - CD8 antigen KW - Transgenic mice KW - Infection KW - Meningitis KW - Promoters KW - Splenocytes KW - CD4 antigen KW - Infectious diseases KW - Kinetics KW - Lymphocytes T KW - Cytokines KW - W 30925:Genetic Engineering KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology+Letters&rft.atitle=Kinetics+of+adaptive+immunity+to+Haemophilus+influenzae+type+b+meningitis+in+transgenic+mice%3A+Evidence+from+diverse+expression+of+double+T1%2FT2+transgenes+and+Th1%2FTh2-related+cytokines&rft.au=Chen%2C+S+J%3BLiao%2C+CL%3BHsieh%2C+S+L%3BChu%2C+M+L%3BFang%2C+M+C%3BSytwu%2C+H+K%3BWang%2C+C+C&rft.aulast=Chen&rft.aufirst=S&rft.date=2006-05-15&rft.volume=105&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Immunology+Letters&rft.issn=01652478&rft_id=info:doi/10.1016%2Fj.imlet.2005.11.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Interleukin 4; Lymphocytes B; Helper cells; Animal models; CD8 antigen; Infection; Transgenic mice; Meningitis; Splenocytes; Promoters; CD4 antigen; Infectious diseases; Kinetics; Lymphocytes T; Cytokines; Haemophilus influenzae DO - http://dx.doi.org/10.1016/j.imlet.2005.11.024 ER - TY - CPAPER T1 - SMAD3 Deficiency Affects the Mechanotransduction of Wound Closure T2 - 16th Annual Meeting and Exhibition of the Wound Healing Society AN - 40076044; 4282785 JF - 16th Annual Meeting and Exhibition of the Wound Healing Society AU - Arany, Praveen R AU - Flanders, Kathleen C AU - Kobayashi, Tetsu AU - Kuo, Catherine K AU - Stuelten, Christina AU - Desai, Kartiki V AU - Tuan, Rocky AU - Rennard, Stephen I AU - Roberts, Anita B Y1 - 2006/05/14/ PY - 2006 DA - 2006 May 14 KW - Mechanotransduction KW - Wounds KW - Smad3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40076044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+and+Exhibition+of+the+Wound+Healing+Society&rft.atitle=SMAD3+Deficiency+Affects+the+Mechanotransduction+of+Wound+Closure&rft.au=Arany%2C+Praveen+R%3BFlanders%2C+Kathleen+C%3BKobayashi%2C+Tetsu%3BKuo%2C+Catherine+K%3BStuelten%2C+Christina%3BDesai%2C+Kartiki+V%3BTuan%2C+Rocky%3BRennard%2C+Stephen+I%3BRoberts%2C+Anita+B&rft.aulast=Arany&rft.aufirst=Praveen&rft.date=2006-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+and+Exhibition+of+the+Wound+Healing+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.woundheal.org/docs/2006AnnMeetingPresentations.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Metrics for Assessment of Exposure to ELF Magnetic Fields in a Population-Based Brain Tumor Study T2 - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AN - 40055371; 4241469 JF - 2006 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2006) AU - Coble, J AU - Dosemeci, M AU - Inskip, P Y1 - 2006/05/13/ PY - 2006 DA - 2006 May 13 KW - Brain tumors KW - Magnetic fields UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.atitle=A+Comparison+of+Metrics+for+Assessment+of+Exposure+to+ELF+Magnetic+Fields+in+a+Population-Based+Brain+Tumor+Study&rft.au=Coble%2C+J%3BDosemeci%2C+M%3BInskip%2C+P&rft.aulast=Coble&rft.aufirst=J&rft.date=2006-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiha.org/Content/CE/aihce/education.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. AN - 67942469; 16533814 AB - Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine (N(epsilon)-(4-amino-2-hydroxybutyl)lysine) in eIF5A. DOHH is a HEAT-repeat protein with eight tandem helical hairpins in a symmetrical dyad. It contains two potential iron coordination sites (one on each dyad) composed of two strictly conserved His-Glu motifs. The purified human recombinant DOHH was a mixture of active holoenzyme containing 2 mol of iron/mol of DOHH and inactive metal-free apoenzyme. The two species could be distinguished by their different mobilities upon native gel electrophoresis. The DOHH apoenzyme exhibited markedly reduced levels of iron and activity. DOHH activity could be restored only by the addition of Fe2+ to the apoenzyme but not by other metals including Cd2+,Co2+,Cr2+,Cu2+,Mg2+,Mn2+,Ni2+, and Zn2+. The role of the strictly conserved His-Glu residues was evaluated by site-directed mutagenesis. Substitution of any single amino acid in the four His-Glu motifs with alanine abolished the enzyme activity. Of these eight alanine substitutions, six, including H56A, H89A, E90A, H207A, H240A, and E241A, caused a severe reduction in the iron content. Our results provide strong evidence that Fe(II) is the active-site-bound metal critical for DOHH catalysis and that the strictly conserved His-Glu motifs are essential for iron binding and catalysis. Furthermore, the iron to DOHH stoichiometry and dependence of iron binding on each of the four conserved His-Glu motifs suggest a binuclear iron mediated reaction mechanism, distinct from that of other Fe(II)-dependent protein hydroxylases, such as prolyl 4-hydroxylase or lysyl hydroxylases. JF - The Journal of biological chemistry AU - Kim, Yeon Sook AU - Kang, Kee Ryeon AU - Wolff, Edith C AU - Bell, Jessica K AU - McPhie, Peter AU - Park, Myung Hee AD - Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4340, USA. Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 SP - 13217 EP - 13225 VL - 281 IS - 19 SN - 0021-9258, 0021-9258 KW - Iron KW - E1UOL152H7 KW - Mixed Function Oxygenases KW - EC 1.- KW - deoxyhypusine hydroxylase KW - EC 1.14.99.29 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Escherichia coli -- metabolism KW - Humans KW - Escherichia coli -- genetics KW - Circular Dichroism KW - Amino Acid Sequence KW - Protein Binding KW - Mutation KW - Protein Conformation KW - Mixed Function Oxygenases -- chemistry KW - Mixed Function Oxygenases -- metabolism KW - Iron -- metabolism KW - Mixed Function Oxygenases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67942469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Deoxyhypusine+hydroxylase+is+a+Fe%28II%29-dependent%2C+HEAT-repeat+enzyme.+Identification+of+amino+acid+residues+critical+for+Fe%28II%29+binding+and+catalysis+%5Bcorrected%5D.&rft.au=Kim%2C+Yeon+Sook%3BKang%2C+Kee+Ryeon%3BWolff%2C+Edith+C%3BBell%2C+Jessica+K%3BMcPhie%2C+Peter%3BPark%2C+Myung+Hee&rft.aulast=Kim&rft.aufirst=Yeon&rft.date=2006-05-12&rft.volume=281&rft.issue=19&rft.spage=13217&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Biochem. 1994 Dec 1;226(2):613-8 [8001576] J Biol Chem. 1995 Apr 14;270(15):8660-6 [7721768] J Biol Chem. 1995 Sep 22;270(38):22386-92 [7673224] Science. 1996 Mar 29;271(5257):1858-60 [8596953] FEBS Lett. 1996 Feb 19;380(3):209-14 [8601426] FEBS Lett. 1996 Apr 15;384(2):151-4 [8612813] Biol Signals. 1997 May-Jun;6(3):105-9 [9285092] Biol Signals. 1997 May-Jun;6(3):124-33 [9285095] Biol Signals. 1997 May-Jun;6(3):166-74 [9285100] J Biol Chem. 1998 Jan 16;273(3):1677-83 [9430712] Adv Enzymol Relat Areas Mol Biol. 1998;72:325-98 [9559057] Biochem Pharmacol. 1998 Jun 1;55(11):1807-18 [9714299] Genetics. 1999 Sep;153(1):135-77 [10471706] Biochem J. 2005 Feb 1;385(Pt 3):779-85 [15377278] J Cell Biol. 2001 Mar 5;152(5):895-910 [11238447] Genome Biol. 2001;2(3):RESEARCH0007 [11276424] J Mol Biol. 2001 May 25;309(1):1-18 [11491282] Methods Enzymol. 2002;350:546-59 [12073335] Int J Cancer. 2002 Aug 1;100(4):491-8 [12115536] Curr Med Chem. 2003 Jun;10(12):1005-19 [12678673] J Biochem. 2003 Jun;133(6):757-65 [12869532] J Biol Chem. 2003 Aug 29;278(35):32683-91 [12788913] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13869-74 [14617780] FEBS Lett. 2003 Dec 18;555(3):464-8 [14675757] Chem Rev. 2004 Feb;104(2):987-1012 [14871147] Differentiation. 2004 Mar;72(2-3):81-91 [15066188] Crit Rev Biochem Mol Biol. 2004 Jan-Feb;39(1):21-68 [15121720] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9595-600 [15210970] Proc Natl Acad Sci U S A. 1975 Nov;72(11):4257-60 [1105576] Biochemistry. 1981 Jan 6;20(1):33-7 [7470476] J Biol Chem. 1984 Oct 10;259(19):12123-7 [6434537] J Biol Chem. 1986 Mar 5;261(7):3085-9 [3949761] Biochem J. 1986 Oct 15;239(2):379-86 [3101665] Mol Cell Biol. 1991 Jun;11(6):3105-14 [1903841] Mol Gen Genet. 1993 Nov;241(3-4):305-11 [8246884] J Cell Biol. 1993 Dec;123(6 Pt 1):1309-20 [8253832] Biochim Biophys Acta. 1994 Mar 31;1221(2):115-24 [8148388] Biochem J. 1994 Oct 15;303 ( Pt 2):363-8 [7980394] J Am Chem Soc. 2005 Nov 23;127(46):16098-106 [16287296] Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):51-6 [16371467] J Biochem. 2006 Feb;139(2):161-9 [16452303] Erratum In: J Biol Chem. 2007 Apr 6;282(14):10840 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system. AN - 67942445; 16531401 AB - Zebrafish is a powerful vertebrate model system for using forward genetics to elucidate mechanisms of early development. We have used chemical mutagenesis to screen for mutants that show defects in the CNS. Here we describe the isolation of the bap28 mutation that leads to abnormalities in the brain starting at midsomitogenesis stages. Mutant embryos display excess apoptosis primarily in the central nervous system (CNS) and die by days 6-7 after fertilization. The mutation was positionally cloned and shown to affect a gene that encodes a large protein with high similarity to the uncharacterized human protein BAP28 and lower similarity to yeast Utp10. Utp10 is a component of a nucleolar U3 small nucleolar RNA-containing RNP complex that is required for transcription of ribosomal DNA and for processing of 18 S rRNA. We show that zebrafish Bap28 likewise is required for rRNA transcription and processing, with a major effect on 18 S rRNA maturation. We suggest that bap28 is required for cell survival in the CNS through its role in rRNA synthesis and processing. Inhibition of p53 protein expression in bap28 mutants led to embryos with morphologically normal appearance, suggesting that p53 is involved in triggering apoptosis in the bap28 mutant CNS. The bap28 mutation provides a genetic approach to study the role of ribosome biogenesis in the development of a vertebrate embryo. JF - The Journal of biological chemistry AU - Azuma, Mizuki AU - Toyama, Reiko AU - Laver, Elizabeth AU - Dawid, Igor B AD - Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 SP - 13309 EP - 13316 VL - 281 IS - 19 SN - 0021-9258, 0021-9258 KW - Bap28 protein, zebrafish KW - 0 KW - RNA, Ribosomal KW - RNA, Ribosomal, 18S KW - Tumor Suppressor Protein p53 KW - Zebrafish Proteins KW - Index Medicus KW - Ribosomes -- metabolism KW - Animals KW - Brain -- metabolism KW - Mutation KW - Zebrafish KW - Gene Expression Regulation, Developmental KW - Brain -- growth & development KW - RNA, Ribosomal, 18S -- metabolism KW - Central Nervous System -- metabolism KW - Apoptosis -- physiology KW - RNA, Ribosomal -- biosynthesis KW - Zebrafish Proteins -- genetics KW - Zebrafish Proteins -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67942445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Perturbation+of+rRNA+synthesis+in+the+bap28+mutation+leads+to+apoptosis+mediated+by+p53+in+the+zebrafish+central+nervous+system.&rft.au=Azuma%2C+Mizuki%3BToyama%2C+Reiko%3BLaver%2C+Elizabeth%3BDawid%2C+Igor+B&rft.aulast=Azuma&rft.aufirst=Mizuki&rft.date=2006-05-12&rft.volume=281&rft.issue=19&rft.spage=13309&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A role for replication repair in the genesis of templated mutations. AN - 67897848; 16574154 AB - Replication repair mediates error-free bypass of DNA damage in a series of steps that include regression of the replication fork, primer-terminus switching to use the other daughter strand as an undamaged template, primer extension, primer switching back to its cognate template with the primer terminus now having bypassed the damage, and fork rearrangement to a normal configuration. By both genetic and biochemical criteria, bacteriophage T4 catalyzes replication repair with two alternative sets of proteins, one including the gp32 SSB and the gp41 DNA helicase and the other including the UvsX recombinase. In each pathway, synthesis is conducted by the gp43 DNA polymerase. Here we show that defects in gp32, gp41 or UvsX that impair replication repair also increase mutation rates generally, but especially for templated mutations. Such templated mutations are associated with palindromic or direct repeats that are either perfect or imperfect. Models of templated mutagenesis require that the primer terminus switches to an ectopic template, but one that yields mutations instead of error-free bypass. We suggest that the proteins that conduct replication repair normally direct a blocked primer strand specifically to the other daughter strand with considerable accuracy, but that strand switching becomes promiscuous when these proteins are mutationally impaired, thus promoting templated mutations. JF - Journal of molecular biology AU - Schultz, Gary E AU - Carver, Geraldine T AU - Drake, John W AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 SP - 963 EP - 973 VL - 358 IS - 4 SN - 0022-2836, 0022-2836 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Base Sequence KW - DNA Damage KW - Models, Genetic KW - Molecular Sequence Data KW - Bacteriophage T4 -- metabolism KW - Genes, Viral KW - Escherichia coli -- virology KW - Bacteriophage T4 -- genetics KW - DNA, Viral -- genetics KW - DNA, Viral -- metabolism KW - DNA Repair KW - Mutation KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67897848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=A+role+for+replication+repair+in+the+genesis+of+templated+mutations.&rft.au=Schultz%2C+Gary+E%3BCarver%2C+Geraldine+T%3BDrake%2C+John+W&rft.aulast=Schultz&rft.aufirst=Gary&rft.date=2006-05-12&rft.volume=358&rft.issue=4&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - IL-21 Down-Regulates NKG2D Expression and Function in Human NK Cells and Differentially Regulates NKG2D and CD28 expression on CD8+ T Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39297173; 4230059 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Borrego, Francisco AU - Burgess, Steven AU - Coligan, John AU - Marusina, Alina Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - NKG2 antigen KW - Interleukin 21 KW - CD28 antigen KW - CD8 antigen KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39297173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=IL-21+Down-Regulates+NKG2D+Expression+and+Function+in+Human+NK+Cells+and+Differentially+Regulates+NKG2D+and+CD28+expression+on+CD8%2B+T+Cells&rft.au=Borrego%2C+Francisco%3BBurgess%2C+Steven%3BColigan%2C+John%3BMarusina%2C+Alina&rft.aulast=Borrego&rft.aufirst=Francisco&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD25+ Regulatory T Cells Exist as Naive and Memory Phenotype Cells with Different Proliferative Rates and Inhibitory Potency T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39296860; 4230022 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Hu-Li, Jane AU - Milner, Joshua AU - Min, Booki AU - Oh, Keunhee AU - Paul, William AU - Thornton, Angela AU - Younes, Souheil Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Memory cells KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39296860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=CD25%2B+Regulatory+T+Cells+Exist+as+Naive+and+Memory+Phenotype+Cells+with+Different+Proliferative+Rates+and+Inhibitory+Potency&rft.au=Hu-Li%2C+Jane%3BMilner%2C+Joshua%3BMin%2C+Booki%3BOh%2C+Keunhee%3BPaul%2C+William%3BThornton%2C+Angela%3BYounes%2C+Souheil&rft.aulast=Hu-Li&rft.aufirst=Jane&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RSV Infection of Human B Lymphocytes Induces Iga Class Switching Through TGF-Beta Signaling T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39294873; 4229139 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Imani, Farhad AU - Sawin, Dixie-Ann Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Infection KW - Lymphocytes KW - Signal transduction KW - Lymphocytes B KW - Immunoglobulin A KW - Class switching KW - Transforming growth factor- beta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39294873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=RSV+Infection+of+Human+B+Lymphocytes+Induces+Iga+Class+Switching+Through+TGF-Beta+Signaling&rft.au=Imani%2C+Farhad%3BSawin%2C+Dixie-Ann&rft.aulast=Imani&rft.aufirst=Farhad&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations in Cognate Activation of Naive CD8+ T Cells Control Differentiation in Effector and Central Memory Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39275436; 4229306 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Chakrabarty, Sagarika AU - Harlan, David AU - Pechhold, Klaus AU - Zhu, Xiaolong Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Memory cells KW - Differentiation KW - CD8 antigen KW - Lymphocytes T KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39275436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Alterations+in+Cognate+Activation+of+Naive+CD8%2B+T+Cells+Control+Differentiation+in+Effector+and+Central+Memory+Cells&rft.au=Chakrabarty%2C+Sagarika%3BHarlan%2C+David%3BPechhold%2C+Klaus%3BZhu%2C+Xiaolong&rft.aulast=Chakrabarty&rft.aufirst=Sagarika&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Progesterone has Differential Effects on Dendritic Cells from Male and Female Rats T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39247059; 4229960 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Belyavskaya, Elena AU - Bowers, Eve AU - Butts, Cherie AU - Horn, Cash AU - Sternberg, Esther Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Rats KW - Dendritic cells KW - Progesterone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39247059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Progesterone+has+Differential+Effects+on+Dendritic+Cells+from+Male+and+Female+Rats&rft.au=Belyavskaya%2C+Elena%3BBowers%2C+Eve%3BButts%2C+Cherie%3BHorn%2C+Cash%3BSternberg%2C+Esther&rft.aulast=Belyavskaya&rft.aufirst=Elena&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Metastasis-Associated 67 kDa Laminin Receptor is Involved in G-CSF-Induced Hematopoietic Stem Cell Mobilization T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39246970; 4229678 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Carriero, Maria Vincenza AU - Montuori, Nunzia AU - Ragno, Pia AU - Ricci, Patrizia AU - Rossi, Guido AU - Rotoli, Bruno AU - Scarpato, Nicola AU - Selleri, Carmine AU - Visconte, Valeria Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Granulocyte colony-stimulating factor KW - Laminin receptors KW - Stem cells KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=The+Metastasis-Associated+67+kDa+Laminin+Receptor+is+Involved+in+G-CSF-Induced+Hematopoietic+Stem+Cell+Mobilization&rft.au=Carriero%2C+Maria+Vincenza%3BMontuori%2C+Nunzia%3BRagno%2C+Pia%3BRicci%2C+Patrizia%3BRossi%2C+Guido%3BRotoli%2C+Bruno%3BScarpato%2C+Nicola%3BSelleri%2C+Carmine%3BVisconte%2C+Valeria&rft.aulast=Carriero&rft.aufirst=Maria&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SOCS1 Regulates CD4+ T Cells Homeostasis and Migration into Secondary Lymphoid Tissues T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39246012; 4229221 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Egwuagu, Charles AU - Liu, Xue-Bin AU - Mahdi, Rashid AU - Takase, Hiroshi AU - Yu, Cheng-Rong AU - Zhang, Allen Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Tissues KW - Lymphoid tissue KW - Lymphocytes T KW - Cell migration KW - CD4 antigen KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=SOCS1+Regulates+CD4%2B+T+Cells+Homeostasis+and+Migration+into+Secondary+Lymphoid+Tissues&rft.au=Egwuagu%2C+Charles%3BLiu%2C+Xue-Bin%3BMahdi%2C+Rashid%3BTakase%2C+Hiroshi%3BYu%2C+Cheng-Rong%3BZhang%2C+Allen&rft.aulast=Egwuagu&rft.aufirst=Charles&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Life and Death Decisions on the Road to T Cell Differentiation and Memory T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39244190; 4228924 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Siegel, R Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Mortality KW - Highways KW - Memory cells KW - Differentiation KW - Lymphocytes T KW - Cell differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39244190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Life+and+Death+Decisions+on+the+Road+to+T+Cell+Differentiation+and+Memory&rft.au=Siegel%2C+R&rft.aulast=Siegel&rft.aufirst=R&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Effects of IL-7 in Regulation of Homeostatic Proliferation and Telomerase Expression in Human Naive and Memory CD4+ T Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39241540; 4229124 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Nan-ping, Weng AU - Yang, Yinhua Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Memory cells KW - Cell proliferation KW - Lymphocytes T KW - Telomerase KW - CD4 antigen KW - Interleukin 7 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39241540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Differential+Effects+of+IL-7+in+Regulation+of+Homeostatic+Proliferation+and+Telomerase+Expression+in+Human+Naive+and+Memory+CD4%2B+T+Cells&rft.au=Nan-ping%2C+Weng%3BYang%2C+Yinhua&rft.aulast=Nan-ping&rft.aufirst=Weng&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Distinct Subset of Foxp3+ T Regulatory Cells Participates in the Control of Innate and Adaptive Immune Responses In Vivo T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39239365; 4229214 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Andersson, John AU - Shevach, Ethan AU - Stephens, Geoffrey Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39239365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=A+Distinct+Subset+of+Foxp3%2B+T+Regulatory+Cells+Participates+in+the+Control+of+Innate+and+Adaptive+Immune+Responses+In+Vivo&rft.au=Andersson%2C+John%3BShevach%2C+Ethan%3BStephens%2C+Geoffrey&rft.aulast=Andersson&rft.aufirst=John&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of CD81 Cysteines in the Function of the CD19/Cd21 Coreceptor Complex T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39230251; 4229168 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Pierce, Susan AU - Wang, Yan Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - CD19 antigen KW - CD81 antigen KW - Cysteine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39230251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=The+Role+of+CD81+Cysteines+in+the+Function+of+the+CD19%2FCd21+Coreceptor+Complex&rft.au=Pierce%2C+Susan%3BWang%2C+Yan&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of KIR Variability on Viral Disease T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39216816; 4229279 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Carrington, Mary Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39216816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Influence+of+KIR+Variability+on+Viral+Disease&rft.au=Carrington%2C+Mary&rft.aulast=Carrington&rft.aufirst=Mary&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kruppel-Like Factor 4 Regulates B Cell Survival and Apoptosis T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39216411; 4229116 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Godlove, Jason AU - Golech, Susanne AU - Kaestner, Klaus AU - Katz, Jonathan AU - Klaewsongkram, Jettanong AU - Segre, Julie AU - Weng, Nan-ping Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes B KW - Apoptosis KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39216411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Kruppel-Like+Factor+4+Regulates+B+Cell+Survival+and+Apoptosis&rft.au=Godlove%2C+Jason%3BGolech%2C+Susanne%3BKaestner%2C+Klaus%3BKatz%2C+Jonathan%3BKlaewsongkram%2C+Jettanong%3BSegre%2C+Julie%3BWeng%2C+Nan-ping&rft.aulast=Godlove&rft.aufirst=Jason&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stat5 Overexpression Results in Immature CD8+ T-Cell Expansion and Lymphoma T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39214806; 4230094 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Al-Shami, Amin AU - Kelly, John AU - Leonard, Warren AU - Paronto, Kate AU - Spolski, Rosanne Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphoma KW - CD8 antigen KW - Lymphocytes T KW - Stat5 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39214806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Stat5+Overexpression+Results+in+Immature+CD8%2B+T-Cell+Expansion+and+Lymphoma&rft.au=Al-Shami%2C+Amin%3BKelly%2C+John%3BLeonard%2C+Warren%3BParonto%2C+Kate%3BSpolski%2C+Rosanne&rft.aulast=Al-Shami&rft.aufirst=Amin&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of T-Cell Homeostasis: Investigating the Possible Interaction between the IL-7 and TCR Signaling Pathways T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39214716; 4230078 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Asefa, Benyam AU - Durum, Scott Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Signal transduction KW - T-cell receptor KW - Lymphocytes T KW - Interleukin 7 KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39214716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Regulation+of+T-Cell+Homeostasis%3A+Investigating+the+Possible+Interaction+between+the+IL-7+and+TCR+Signaling+Pathways&rft.au=Asefa%2C+Benyam%3BDurum%2C+Scott&rft.aulast=Asefa&rft.aufirst=Benyam&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Mimicry and Autoimmunity Via Degenerate Antigen Recognition in Humanized Myelin-Reactive TCR Transgenic Mice T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39213250; 4228563 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Huh, Jaebong AU - Ito, Kouichi AU - Martin, Roland AU - Pinilla, Clemencia AU - Quandt, Jacqueline Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Mice KW - T-cell receptor KW - Autoimmunity KW - Transgenic mice KW - Antigens KW - Mimicry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39213250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Molecular+Mimicry+and+Autoimmunity+Via+Degenerate+Antigen+Recognition+in+Humanized+Myelin-Reactive+TCR+Transgenic+Mice&rft.au=Huh%2C+Jaebong%3BIto%2C+Kouichi%3BMartin%2C+Roland%3BPinilla%2C+Clemencia%3BQuandt%2C+Jacqueline&rft.aulast=Huh&rft.aufirst=Jaebong&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Avidity of CD8 T-Cells Sharpens Immunodominance. T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39213057; 4229248 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Belyakov, Igor AU - Dzutsev, Amiran AU - Isakov, Dmitry AU - Margulies, David Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Avidity KW - Immunodominance KW - CD8 antigen KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39213057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Avidity+of+CD8+T-Cells+Sharpens+Immunodominance.&rft.au=Belyakov%2C+Igor%3BDzutsev%2C+Amiran%3BIsakov%2C+Dmitry%3BMargulies%2C+David&rft.aulast=Belyakov&rft.aufirst=Igor&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39212970; 4229215 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Bryceson, Yenan AU - Geraghty, Daniel AU - Joosten, Irma AU - Kuppusamy, Shanmuga AU - Long, Eric AU - Rajagopalan, Sumati AU - van der Meer, Arnold Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Histocompatibility antigen HLA KW - Natural killer cells KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Activation+of+NK+Cells+by+an+Endocytosed+Receptor+for+Soluble+HLA-G&rft.au=Bryceson%2C+Yenan%3BGeraghty%2C+Daniel%3BJoosten%2C+Irma%3BKuppusamy%2C+Shanmuga%3BLong%2C+Eric%3BRajagopalan%2C+Sumati%3Bvan+der+Meer%2C+Arnold&rft.aulast=Bryceson&rft.aufirst=Yenan&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-10 Production by Conventional Th1 Cells Provides Negative Feedback Regulation of IFN-g Secretion during Anti-Microbial Responses T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39212840; 4229189 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Caspar, Patricia AU - Jankovic, Dragana AU - Kullberg, Marika AU - Sher, Alan Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Interleukin 10 KW - Feedback KW - gamma -Interferon KW - Lymphocytes T KW - Helper cells KW - Secretion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=IL-10+Production+by+Conventional+Th1+Cells+Provides+Negative+Feedback+Regulation+of+IFN-g+Secretion+during+Anti-Microbial+Responses&rft.au=Caspar%2C+Patricia%3BJankovic%2C+Dragana%3BKullberg%2C+Marika%3BSher%2C+Alan&rft.aulast=Caspar&rft.aufirst=Patricia&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Transcriptional Regulation of B7-H1 Expression in Human Dendritic Cells Occurs through an Erk-Dependent and TNF-a-Independent Pathway T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39212775; 4229171 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - DellAgnola, Chiara AU - Espinoza-Delgado, Igor AU - Li, Huifen AU - Lopez, Natalia AU - Wojciechowski, Wojciech Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Dendritic cells KW - Post-transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Post-Transcriptional+Regulation+of+B7-H1+Expression+in+Human+Dendritic+Cells+Occurs+through+an+Erk-Dependent+and+TNF-a-Independent+Pathway&rft.au=DellAgnola%2C+Chiara%3BEspinoza-Delgado%2C+Igor%3BLi%2C+Huifen%3BLopez%2C+Natalia%3BWojciechowski%2C+Wojciech&rft.aulast=DellAgnola&rft.aufirst=Chiara&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antagonism between Gai2 and Gai3 in CXCR3-Mediated Signaling T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39212733; 4229153 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Birnbaumer, Lutz AU - Jin, Yongzhu AU - Kochevar, Irene AU - Thompson, Brian AU - Wu, Mei Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Signal transduction KW - Antagonism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Antagonism+between+Gai2+and+Gai3+in+CXCR3-Mediated+Signaling&rft.au=Birnbaumer%2C+Lutz%3BJin%2C+Yongzhu%3BKochevar%2C+Irene%3BThompson%2C+Brian%3BWu%2C+Mei&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Telomere Length as a Potential Selection Marker in Adoptive Cell Transfer Therapy for Melanoma Patients T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39212667; 4229373 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Dudley, Mark AU - El-Gamil, Mona AU - Li, Yong AU - Robbins, Paul AU - Rosenberg, Steven AU - Zhou, Juhua Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Melanoma KW - Telomeres KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Telomere+Length+as+a+Potential+Selection+Marker+in+Adoptive+Cell+Transfer+Therapy+for+Melanoma+Patients&rft.au=Dudley%2C+Mark%3BEl-Gamil%2C+Mona%3BLi%2C+Yong%3BRobbins%2C+Paul%3BRosenberg%2C+Steven%3BZhou%2C+Juhua&rft.aulast=Dudley&rft.aufirst=Mark&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of HLA-A2 Restricted CD8+ T Cell Responses to Chlamydia Pneumoniae T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39211305; 4228861 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Appella, Ettore AU - Cortes, Claudio AU - Sette, Alessandro AU - Sidney, John AU - Tvinnereim, Amy AU - Wizel, Benjamin Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Histocompatibility antigen HLA KW - CD8 antigen KW - Lymphocytes T KW - Chlamydophila pneumoniae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39211305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Analysis+of+HLA-A2+Restricted+CD8%2B+T+Cell+Responses+to+Chlamydia+Pneumoniae&rft.au=Appella%2C+Ettore%3BCortes%2C+Claudio%3BSette%2C+Alessandro%3BSidney%2C+John%3BTvinnereim%2C+Amy%3BWizel%2C+Benjamin&rft.aulast=Appella&rft.aufirst=Ettore&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccination Preserves Pre-Existing Memory CD4 T-Cells during Acute Siv Infection T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39210925; 4228731 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Buckler-White, Alicia AU - Douek, Daniel AU - Letvin, Norman AU - Martin, Malcolm AU - Mattapallil, Joseph AU - Montefiori, David AU - Nabel, Gary AU - Roederer, Mario Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Infection KW - Vaccination KW - Lymphocytes T KW - Immunological memory KW - CD4 antigen KW - Simian immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Vaccination+Preserves+Pre-Existing+Memory+CD4+T-Cells+during+Acute+Siv+Infection&rft.au=Buckler-White%2C+Alicia%3BDouek%2C+Daniel%3BLetvin%2C+Norman%3BMartin%2C+Malcolm%3BMattapallil%2C+Joseph%3BMontefiori%2C+David%3BNabel%2C+Gary%3BRoederer%2C+Mario&rft.aulast=Buckler-White&rft.aufirst=Alicia&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Population of Igd+Cd27- B Cells Similar to Activated Splenic Marginal Zone B Cells is Found in the Blood of Patients with Active SLE, Correlates with Disease, and is Sensitive to Il6 Receptor Block T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39209601; 4229104 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Fischer, Randy AU - Grammer, Amrie AU - Hardin, John AU - Illei, Gabor AU - Lipsky, Peter AU - Longo, Nancy AU - Lugar, Patricia AU - Okada, Sarah AU - Slota, Rebecca AU - Yarboro, Cheryl Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Blood KW - Lymphocytes B KW - Spleen KW - Interleukin 6 KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39209601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=A+Population+of+Igd%2BCd27-+B+Cells+Similar+to+Activated+Splenic+Marginal+Zone+B+Cells+is+Found+in+the+Blood+of+Patients+with+Active+SLE%2C+Correlates+with+Disease%2C+and+is+Sensitive+to+Il6+Receptor+Block&rft.au=Fischer%2C+Randy%3BGrammer%2C+Amrie%3BHardin%2C+John%3BIllei%2C+Gabor%3BLipsky%2C+Peter%3BLongo%2C+Nancy%3BLugar%2C+Patricia%3BOkada%2C+Sarah%3BSlota%2C+Rebecca%3BYarboro%2C+Cheryl&rft.aulast=Fischer&rft.aufirst=Randy&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Somatic Hypermutation in X-HIgM Syndrome Reveals a Unique Pattern Consistent with Targeting during DNA Replication T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39204443; 4230067 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Krijger, Peter AU - Lipsky, Peter AU - Longo, Nancy AU - Yavuz, Sule Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - DNA KW - Replication KW - DNA biosynthesis KW - Somatic hypermutation KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Analysis+of+Somatic+Hypermutation+in+X-HIgM+Syndrome+Reveals+a+Unique+Pattern+Consistent+with+Targeting+during+DNA+Replication&rft.au=Krijger%2C+Peter%3BLipsky%2C+Peter%3BLongo%2C+Nancy%3BYavuz%2C+Sule&rft.aulast=Krijger&rft.aufirst=Peter&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-10 Protects Dopaminergic Neurons from LPS-induced Neurotoxicity in Rat Primary Midbrain Cultures T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39204002; 4229897 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Block, Michelle AU - Flood, Patrick AU - Hong, Jau-Shyong AU - Qian, Li AU - Wilson, Belinda Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Neurotoxicity KW - Interleukin 10 KW - Cell culture KW - Mesencephalon KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=IL-10+Protects+Dopaminergic+Neurons+from+LPS-induced+Neurotoxicity+in+Rat+Primary+Midbrain+Cultures&rft.au=Block%2C+Michelle%3BFlood%2C+Patrick%3BHong%2C+Jau-Shyong%3BQian%2C+Li%3BWilson%2C+Belinda&rft.aulast=Block&rft.aufirst=Michelle&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receptors for NK Cell Activation T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39202989; 4228959 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Long, E Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Cell activation KW - Natural killer cells KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Receptors+for+NK+Cell+Activation&rft.au=Long%2C+E&rft.aulast=Long&rft.aufirst=E&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multifaceted Role of Ubiquitin in Pro- And Anti-Apoptotic Signaling Pathways T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39202874; 4228922 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Ashwell, J Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Signal transduction KW - Ubiquitin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Multifaceted+Role+of+Ubiquitin+in+Pro-+And+Anti-Apoptotic+Signaling+Pathways&rft.au=Ashwell%2C+J&rft.aulast=Ashwell&rft.aufirst=J&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parallel use of LAB/NTAL and LAT for Itam Signaling in NK Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39202839; 4229274 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - McVicar, D Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Signal transduction KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Parallel+use+of+LAB%2FNTAL+and+LAT+for+Itam+Signaling+in+NK+Cells&rft.au=McVicar%2C+D&rft.aulast=McVicar&rft.aufirst=D&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study on the Regulatory Roles of SHIP2 in Mast Cell Activation T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39202031; 4228816 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Bolland, Silvia AU - Leung, Wai-Hang Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Mast cells KW - Inositol polyphosphate 5-phosphatase KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Study+on+the+Regulatory+Roles+of+SHIP2+in+Mast+Cell+Activation&rft.au=Bolland%2C+Silvia%3BLeung%2C+Wai-Hang&rft.aulast=Bolland&rft.aufirst=Silvia&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Oral Cancer Cells Induce CD4+Cd25+Foxp3+ Regulatory Cells from CD4+Cd25- T Cells through Production of TGF-Beta T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39201986; 4228812 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Amarnath, Shoba AU - Chen, Wanjun AU - Gutkind, Sylvio AU - Patel, Vyomesh Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Cancer KW - Lymphocytes T KW - Immunoregulation KW - Transforming growth factor- beta KW - Oropharyngeal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39201986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Human+Oral+Cancer+Cells+Induce+CD4%2BCd25%2BFoxp3%2B+Regulatory+Cells+from+CD4%2BCd25-+T+Cells+through+Production+of+TGF-Beta&rft.au=Amarnath%2C+Shoba%3BChen%2C+Wanjun%3BGutkind%2C+Sylvio%3BPatel%2C+Vyomesh&rft.aulast=Amarnath&rft.aufirst=Shoba&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ying and Yang Immune Effects of Tumor Necrosis Factor-Alpha is Based on Effects on CD4+Cd25+ T Regulatory Cells and T Effector Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39197841; 4228819 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Chen, Xin AU - Howard, O M AU - Oppenheim, Joost Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Effector cells KW - Tumor necrosis factor- alpha KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39197841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Ying+and+Yang+Immune+Effects+of+Tumor+Necrosis+Factor-Alpha+is+Based+on+Effects+on+CD4%2BCd25%2B+T+Regulatory+Cells+and+T+Effector+Cells&rft.au=Chen%2C+Xin%3BHoward%2C+O+M%3BOppenheim%2C+Joost&rft.aulast=Chen&rft.aufirst=Xin&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Interferon Consensus Sequence Binding Protein (ICSBP) in the regulation of tumor-induced CD11b+Gr1+ Myeloid Suppressor Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39194182; 4230317 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Abrams, Scott AU - Greeneltch, Kristy AU - Liu, Kebin AU - Schneider, Monika AU - Stewart, Trina Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Proteins KW - Conserved sequence KW - Interferon KW - CD11b antigen KW - Amino acid sequence KW - Suppressor cells KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39194182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Role+of+Interferon+Consensus+Sequence+Binding+Protein+%28ICSBP%29+in+the+regulation+of+tumor-induced+CD11b%2BGr1%2B+Myeloid+Suppressor+Cells&rft.au=Abrams%2C+Scott%3BGreeneltch%2C+Kristy%3BLiu%2C+Kebin%3BSchneider%2C+Monika%3BStewart%2C+Trina&rft.aulast=Abrams&rft.aufirst=Scott&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Male and Female Rat Expression of Steroid Hormone Receptors in Immune Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39192280; 4230246 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Belyavskaya, Elena AU - Bowers, Eve AU - Butts, Cherie AU - Horn, Cash AU - Sternberg, Esther Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Steroid hormones KW - Steroid hormone receptors KW - Receptors KW - Hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39192280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Comparison+of+Male+and+Female+Rat+Expression+of+Steroid+Hormone+Receptors+in+Immune+Cells&rft.au=Belyavskaya%2C+Elena%3BBowers%2C+Eve%3BButts%2C+Cherie%3BHorn%2C+Cash%3BSternberg%2C+Esther&rft.aulast=Belyavskaya&rft.aufirst=Elena&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of TLR3 and Scavenger Receptor in DsRNA Induction of TNF-Alpha in Human Epithelial Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39192022; 4228666 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Chrysovergis, Kaliopi AU - Imani, Farhad AU - Limmon, Gino Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Double-stranded RNA KW - Epithelial cells KW - Scavenger receptors KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39192022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Role+of+TLR3+and+Scavenger+Receptor+in+DsRNA+Induction+of+TNF-Alpha+in+Human+Epithelial+Cells&rft.au=Chrysovergis%2C+Kaliopi%3BImani%2C+Farhad%3BLimmon%2C+Gino&rft.aulast=Chrysovergis&rft.aufirst=Kaliopi&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Toll-Like Receptor 2 on Microglia Promotes Cell Up-take of Alzheimers Disease-Associated beta -Amyloid Peptide T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39184803; 4229418 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Chen, Keqiang AU - Chen, Jianhong AU - Cho, Edward AU - Dunlop, Nancy AU - Gong, Wanghua AU - Hu, Jinyue AU - Iribarren, Pablo AU - Lockett, Stephen AU - Wang, Ji Ming Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Microglia KW - beta -Amyloid KW - Toll-like receptors KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39184803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Activation+of+Toll-Like+Receptor+2+on+Microglia+Promotes+Cell+Up-take+of+Alzheimers+Disease-Associated+beta+-Amyloid+Peptide&rft.au=Chen%2C+Keqiang%3BChen%2C+Jianhong%3BCho%2C+Edward%3BDunlop%2C+Nancy%3BGong%2C+Wanghua%3BHu%2C+Jinyue%3BIribarren%2C+Pablo%3BLockett%2C+Stephen%3BWang%2C+Ji+Ming&rft.aulast=Chen&rft.aufirst=Keqiang&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR7 Gene Duplication Accelerates Autoimmunity and Promotes Nucleolar-Specific B Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39184738; 4229500 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Bolland, Silvia AU - Deane, Jonathan AU - Difilippantonio, Michael AU - Pisitkun, Prapaporn AU - Satterthwaite, Anne AU - Tarasenko, Tatyana Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes B KW - Autoimmunity KW - Gene duplication KW - Toll-like receptors KW - TLR7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39184738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=TLR7+Gene+Duplication+Accelerates+Autoimmunity+and+Promotes+Nucleolar-Specific+B+Cells&rft.au=Bolland%2C+Silvia%3BDeane%2C+Jonathan%3BDifilippantonio%2C+Michael%3BPisitkun%2C+Prapaporn%3BSatterthwaite%2C+Anne%3BTarasenko%2C+Tatyana&rft.aulast=Bolland&rft.aufirst=Silvia&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Competitive and Cooperative Regulation of TNFR1-Induced Death Versus Survival Signals by TRADD and RIP1 T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39184586; 4229362 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Bidere, Nicolas AU - Chan, Francis AU - Lenardo, Michael AU - Zheng, Lixn Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Mortality KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39184586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Competitive+and+Cooperative+Regulation+of+TNFR1-Induced+Death+Versus+Survival+Signals+by+TRADD+and+RIP1&rft.au=Bidere%2C+Nicolas%3BChan%2C+Francis%3BLenardo%2C+Michael%3BZheng%2C+Lixn&rft.aulast=Bidere&rft.aufirst=Nicolas&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immuno-Spin Trapping T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39183068; 4229007 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Mejiba, Sandra Gomez AU - Mason, Ronald AU - Ramirez, Dario Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Trapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39183068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Immuno-Spin+Trapping&rft.au=Mejiba%2C+Sandra+Gomez%3BMason%2C+Ronald%3BRamirez%2C+Dario&rft.aulast=Mejiba&rft.aufirst=Sandra&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunotherapy Directed to Tumor and its Microenvironment T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39182472; 4229076 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Niederhuber, JohnNB Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Immunotherapy KW - Microenvironments KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39182472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Immunotherapy+Directed+to+Tumor+and+its+Microenvironment&rft.au=Niederhuber%2C+JohnNB&rft.aulast=Niederhuber&rft.aufirst=JohnNB&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HLA -DR and -DQ Allele Interactions Control Susceptibility to Autoimmune Retinal Disease T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39182290; 4229097 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Caspi, Rachel AU - Chan, Chi-Chao AU - Cortes, Lizette AU - David, Chella AU - Donoso, Larry AU - Mattapallil, Mary AU - McDowell, Hugh AU - Silver, Phyllis AU - Viley, Angelia Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Histocompatibility antigen HLA KW - Allelles KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39182290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=HLA+-DR+and+-DQ+Allele+Interactions+Control+Susceptibility+to+Autoimmune+Retinal+Disease&rft.au=Caspi%2C+Rachel%3BChan%2C+Chi-Chao%3BCortes%2C+Lizette%3BDavid%2C+Chella%3BDonoso%2C+Larry%3BMattapallil%2C+Mary%3BMcDowell%2C+Hugh%3BSilver%2C+Phyllis%3BViley%2C+Angelia&rft.aulast=Caspi&rft.aufirst=Rachel&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic Profiling of Inflammatory Gene Expression in Double-Stranded RNA-Treated Human Epithelial Cells T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39174955; 4228867 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Imani, Farhad AU - Limmon, Gino Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Kinetics KW - Gene expression KW - Epithelial cells KW - Inflammation KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39174955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Kinetic+Profiling+of+Inflammatory+Gene+Expression+in+Double-Stranded+RNA-Treated+Human+Epithelial+Cells&rft.au=Imani%2C+Farhad%3BLimmon%2C+Gino&rft.aulast=Imani&rft.aufirst=Farhad&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interferon-Inducible GTPase LRG-47 is Required for the Hematopoietic Stem Cell Response to Proliferative Stimuli T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39173144; 4229679 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Feng, Carl AU - Goodell, Margaret AU - Sher, Alan AU - Weksberg, David Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Guanosinetriphosphatase KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39173144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=The+Interferon-Inducible+GTPase+LRG-47+is+Required+for+the+Hematopoietic+Stem+Cell+Response+to+Proliferative+Stimuli&rft.au=Feng%2C+Carl%3BGoodell%2C+Margaret%3BSher%2C+Alan%3BWeksberg%2C+David&rft.aulast=Feng&rft.aufirst=Carl&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The TNF-Family Ligand TL1A is Induced by Innate and Adaptive Immune Stimuli and Biases T Cells Towards Th2 Differentiation T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39172806; 4230183 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Boesen, Agnieszka AU - Deyev, Vadim AU - Jankovic, Dragana AU - Keane-Myers, Andrea AU - Kinder, Michelle AU - Meylan, Francoise AU - Nutman, Tom AU - Semnani, Roshanak AU - Sher, Alan AU - Wang, Eddie Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes T KW - Differentiation KW - Helper cells KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39172806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=The+TNF-Family+Ligand+TL1A+is+Induced+by+Innate+and+Adaptive+Immune+Stimuli+and+Biases+T+Cells+Towards+Th2+Differentiation&rft.au=Boesen%2C+Agnieszka%3BDeyev%2C+Vadim%3BJankovic%2C+Dragana%3BKeane-Myers%2C+Andrea%3BKinder%2C+Michelle%3BMeylan%2C+Francoise%3BNutman%2C+Tom%3BSemnani%2C+Roshanak%3BSher%2C+Alan%3BWang%2C+Eddie&rft.aulast=Boesen&rft.aufirst=Agnieszka&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodefense and Pandemic Preparedness: The Research Agenda T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39169193; 4228475 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Fauci, A Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39169193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=Biodefense+and+Pandemic+Preparedness%3A+The+Research+Agenda&rft.au=Fauci%2C+A&rft.aulast=Fauci&rft.aufirst=A&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD4+CD25+ Regulatory T Cells are Activated In Vivo by Recognition of Self T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39163594; 4229211 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Andersson, John AU - Shevach, Ethan AU - Stefanova, Irena AU - Stephens, Geoffrey Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen KW - Self KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39163594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=CD4%2BCD25%2B+Regulatory+T+Cells+are+Activated+In+Vivo+by+Recognition+of+Self&rft.au=Andersson%2C+John%3BShevach%2C+Ethan%3BStefanova%2C+Irena%3BStephens%2C+Geoffrey&rft.aulast=Andersson&rft.aufirst=John&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Non-Classical Type II NKT Cell Suppresses Tumor Immunity T2 - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AN - 39151039; 4230318 JF - 2006 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2006) AU - Ambrosino, Elena AU - Berzofsky, Jay AU - Godfrey, Dale AU - Hayakawa, Yoshihiro AU - Ostrand-Rosenberg, Suzanne AU - Sinha, Pratima AU - Smyth, Mark AU - Swann, Jeremy AU - Takaku, Shun AU - Terabe, Masaki Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 KW - Immunity KW - Killer cells KW - Lymphocytes T KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39151039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.atitle=A+Non-Classical+Type+II+NKT+Cell+Suppresses+Tumor+Immunity&rft.au=Ambrosino%2C+Elena%3BBerzofsky%2C+Jay%3BGodfrey%2C+Dale%3BHayakawa%2C+Yoshihiro%3BOstrand-Rosenberg%2C+Suzanne%3BSinha%2C+Pratima%3BSmyth%2C+Mark%3BSwann%2C+Jeremy%3BTakaku%2C+Shun%3BTerabe%2C+Masaki&rft.aulast=Ambrosino&rft.aufirst=Elena&rft.date=2006-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/aai2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The changing spectrum of pulmonary disease in patients with HIV infection on antiretroviral therapy AN - 19847068; 6963479 AB - The pulmonary manifestations of HIV disease in 2005 can be divided into two sets of presentations. For patients who do not have access to care, and who are not taking antiretroviral or chemoprophylactic drugs, opportunistic infections and neoplasms continue to occur. Pulmonary disease caused by Streptococcus pneumoniae, Pneumocystis carinii (now known as Pneumocystis jiroveci pneumonia; PCP), Mycobacterium tuberculosis, lymphoma, and Kaposi's sarcoma present much as they did in the 1980s. Management has improved in terms of new diagnostic, therapeutic, and preventive strategies, as reviewed in guidelines issued jointly by the National Institutes of Health, Centers for Disease Control and Prevention, and Infectious Disease Society of America (available online at http://www.aidsinfo.nih.gov). Patients in the United States who are taking combination antiretroviral therapy (ART) and specific chemoprophylaxis demonstrate very different manifestations compared with patients in the 1980s who were receiving no ART or chemoprophylaxis. Some of these new manifestations are caused by the augmented immune response that occurs soon after ART is instituted, i.e. immune reconstitution syndromes. Other new manifestations are facilitated by prolonged patient survival at both high and low CD4 T-lymphocyte counts that result from ART. This prolonged survival has allowed other processes to occur after long periods of immunosuppression, e.g. neoplastic processes such as lymphoma and perhaps various solid tumors, and other entities such as pulmonary hypertension. This review will focus primarily on changing pulmonary manifestations in the populations in the United States and western Europe that have access to ART. JF - AIDS AU - Grubb, J R AU - Moorman, A C AU - Baker, R K AU - Masur, H AD - Critical Care Medicine Department, Clinical Center, 9000 Rockville Pike, Bethesda, MD 20892, USA, hmasur@cc.nih.gov Y1 - 2006/05/12/ PY - 2006 DA - 2006 May 12 SP - 1095 EP - 1107 VL - 20 IS - 8 SN - 0269-9370, 0269-9370 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Cell survival KW - Disease control KW - Europe KW - Immune reconstitution KW - CD4 antigen KW - Infectious diseases KW - Antiviral agents KW - Lymphocytes T KW - Lymphoma KW - Drugs KW - Pneumocystis carinii KW - Solid tumors KW - antiretroviral therapy KW - Lung diseases KW - Opportunist infection KW - USA KW - Streptococcus pneumoniae KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - Immune response KW - Pneumonia KW - Mycobacterium tuberculosis KW - Hypertension KW - Immunosuppression KW - F 06308:Clinical: AIDS KW - J 02350:Immunology KW - V 22004:AIDS: Clinical aspects KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=The+changing+spectrum+of+pulmonary+disease+in+patients+with+HIV+infection+on+antiretroviral+therapy&rft.au=Grubb%2C+J+R%3BMoorman%2C+A+C%3BBaker%2C+R+K%3BMasur%2C+H&rft.aulast=Grubb&rft.aufirst=J&rft.date=2006-05-12&rft.volume=20&rft.issue=8&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Solid tumors; antiretroviral therapy; Lung diseases; Disease control; Opportunist infection; Immune reconstitution; CD4 antigen; Antiviral agents; Kaposi's sarcoma; Infectious diseases; Lymphocytes T; Immune response; Drugs; Lymphoma; Pneumonia; Immunosuppression; Hypertension; Streptococcus pneumoniae; Pneumocystis carinii; Human immunodeficiency virus; Mycobacterium tuberculosis; USA; Europe ER - TY - JOUR T1 - Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. AN - 67970387; 16473384 AB - The RNase H cleavages that generate and remove the polypurine tract (PPT) primer during retroviral reverse transcription must be specific to generate linear viral DNAs that are suitable substrates for the viral integrase. To determine if specific contacts between reverse transcriptase (RT) and the PPT are a critical factor in determining the cleavage specificity of RNase H, we made HIV-1 viruses containing mutations in RT and the PPT at the locations of critical contacts between the protein and the nucleic acid. The effects on titer and RNase H cleavage suggest that combining mutations in RT with mutations in the PPT affect the structure of the protein of the RT/nucleic acid complex in ways that affect the specificity and the rate of PPT cleavage. In contrast, the mutations in the PPT (alone) and RT (alone) affect the specificity of PPT cleavage but have much less effect on the overall rate of cleavage. JF - Virology AU - McWilliams, Mary Jane AU - Julias, John G AU - Sarafianos, Stefan G AU - Alvord, W Gregory AU - Arnold, Eddy AU - Hughes, Stephen H AD - HIV Drug Resistance Program, NCI-Frederick, MD 21702-1201, USA. Y1 - 2006/05/10/ PY - 2006 DA - 2006 May 10 SP - 378 EP - 388 VL - 348 IS - 2 SN - 0042-6822, 0042-6822 KW - DNA, Viral KW - 0 KW - Macromolecular Substances KW - RNA, Viral KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Ribonuclease H KW - EC 3.1.26.4 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - DNA, Viral -- biosynthesis KW - Base Sequence KW - Transfection KW - Kinetics KW - Humans KW - Substrate Specificity KW - DNA, Viral -- genetics KW - Cell Line KW - HIV Reverse Transcriptase -- genetics KW - HIV-1 -- metabolism KW - HIV-1 -- genetics KW - RNA, Viral -- chemistry KW - HIV Reverse Transcriptase -- metabolism KW - HIV Reverse Transcriptase -- chemistry KW - RNA, Viral -- genetics KW - Ribonuclease H -- metabolism KW - RNA, Viral -- metabolism KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67970387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Combining+mutations+in+HIV-1+reverse+transcriptase+with+mutations+in+the+HIV-1+polypurine+tract+affects+RNase+H+cleavages+involved+in+PPT+utilization.&rft.au=McWilliams%2C+Mary+Jane%3BJulias%2C+John+G%3BSarafianos%2C+Stefan+G%3BAlvord%2C+W+Gregory%3BArnold%2C+Eddy%3BHughes%2C+Stephen+H&rft.aulast=McWilliams&rft.aufirst=Mary&rft.date=2006-05-10&rft.volume=348&rft.issue=2&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Biological Basis for Disorders of Bone Matrix T2 - 33rd European Symposium on Calcified Tissues (ECTS 2006) AN - 40039051; 4208488 JF - 33rd European Symposium on Calcified Tissues (ECTS 2006) AU - Robey, P G Y1 - 2006/05/10/ PY - 2006 DA - 2006 May 10 KW - Bone matrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40039051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=33rd+European+Symposium+on+Calcified+Tissues+%28ECTS+2006%29&rft.atitle=The+Biological+Basis+for+Disorders+of+Bone+Matrix&rft.au=Robey%2C+P+G&rft.aulast=Robey&rft.aufirst=P&rft.date=2006-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=33rd+European+Symposium+on+Calcified+Tissues+%28ECTS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ectsoc.org/prague2006/prog/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Is epirubicin effective in first-line chemotherapy of metastatic breast cancer (MBC) after an epirubicin-containing adjuvant treatment? A single centre phase III trial AN - 230005461; 16622454 AB - The aim of the study was to demonstrate the superiority of docetaxel and epirubicin vs docetaxel alone as first-line therapy in metastatic breast cancer patients pretreated with adjuvant or neoadjuvant epirubicin. We compared single agent docetaxel 100 mg m-2 (D) with the combination of docetaxel 80 mg m-2 and epirubicin 75 mg m-2 (ED). The response rate (72 vs 79%), the progression-free survival (median 9 vs 11 months) and the overall survival (median 18 vs 21 months) were not significantly different between the ED (n=26) and D arms (n=25), respectively. Leucopaenia, nausea and stomatitis were significantly worse with ED. In conclusion, epirubicin should not be administered in combination with taxanes in metastatic breast cancer patients relapsed after an anthracycline-based adjuvant or neoadjuvant therapy. JF - The British Journal of Cancer AU - Pacilio, C AU - Morabito, A AU - Nuzzo, F AU - Gravina, A AU - Labonia, V AU - Landi, G AU - Rossi, E AU - De Maio, E AU - M Di Maio AU - D'aiuto, G AU - Botti, G AU - Normanno, N AU - Chiodini, P AU - Gallo, C AU - Perrone, F AU - de Matteis, A Y1 - 2006/05/08/ PY - 2006 DA - 2006 May 08 SP - 1233 EP - 6 CY - London PB - Nature Publishing Group VL - 94 IS - 9 SN - 00070920 KW - Medical Sciences--Oncology KW - Antibiotics, Antineoplastic KW - Taxoids KW - docetaxel KW - Epirubicin KW - Neoplasm Recurrence, Local -- drug therapy KW - Breast Neoplasms -- pathology KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Epirubicin -- administration & dosage KW - Female KW - Taxoids -- administration & dosage KW - Survival Analysis KW - Breast Neoplasms -- drug therapy KW - Epirubicin -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/230005461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Cancer&rft.atitle=Is+epirubicin+effective+in+first-line+chemotherapy+of+metastatic+breast+cancer+%28MBC%29+after+an+epirubicin-containing+adjuvant+treatment%3F+A+single+centre+phase+III+trial&rft.au=Pacilio%2C+C%3BMorabito%2C+A%3BNuzzo%2C+F%3BGravina%2C+A%3BLabonia%2C+V%3BLandi%2C+G%3BRossi%2C+E%3BDe+Maio%2C+E%3BM+Di+Maio%3BD%27aiuto%2C+G%3BBotti%2C+G%3BNormanno%2C+N%3BChiodini%2C+P%3BGallo%2C+C%3BPerrone%2C+F%3Bde+Matteis%2C+A&rft.aulast=Pacilio&rft.aufirst=C&rft.date=2006-05-08&rft.volume=94&rft.issue=9&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603096 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group May 8, 2006 N1 - Last updated - 2014-04-29 N1 - CODEN - BJCAAI DO - http://dx.doi.org/10.1038/sj.bjc.6603096 ER - TY - JOUR T1 - Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells AN - 19919111; 6811041 AB - Melanoblasts (Mbs) are thought to be strictly regulated by cell-cell interactions with epidermal keratinocytes, although the precise molecular mechanism of the regulation has been elusive. Notch signaling, whose activation is mediated by cell-cell interactions, is implicated in a broad range of developmental processes. We demonstrate the vital role of Notch signaling in the maintenance of Mbs, as well as melanocyte stem cells (MSCs). Conditional ablation of Notch signaling in the melanocyte lineage leads to a severe defect in hair pigmentation, followed by intensive hair graying. The defect is caused by a dramatic elimination of Mbs and MSCs. Furthermore, targeted overexpression of Hes1 is sufficient to protect Mbs from the elimination by apoptosis. Thus, these data provide evidence that Notch signaling, acting through Hes1, plays a crucial role in the survival of immature Mbs by preventing initiation of apoptosis. JF - Journal of Cell Biology AU - Moriyama, Mariko AU - Osawa, Masatake AU - Mak, Siu-Shan AU - Ohtsuka, Toshiyuki AU - Yamamoto, Norio AU - Han, Hua AU - Delmas, Veronique AU - Kageyama, Ryoichiro AU - Beermann, Friedrich AU - Larue, Lionel AU - Nishikawa, Shin-Ichi AD - Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Hyogo 650-0047, Japan. Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, MD 20892. Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xian 710032, China. Developmental Genetics of Melanocytes, Centre National de la Recherche Scientifique UMR146, Institut Curie, 91405 Orsay, France. Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland Y1 - 2006/05/08/ PY - 2006 DA - 2006 May 08 SP - 333 EP - 339 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 173 IS - 3 SN - 0021-9525, 0021-9525 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell survival KW - Pigmentation KW - Molecular modelling KW - Apoptosis KW - Data processing KW - Survival KW - Melanocytes KW - Hair KW - Notch protein KW - Stem cells KW - Transcription factors KW - NOTCH protein KW - Keratinocytes KW - Cell interactions KW - Signal transduction KW - N 14085:DNA: Transcription factors, repressors, nucleoproteins & DNA-binding proteins KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19919111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Biology&rft.atitle=Notch+signaling+via+Hes1+transcription+factor+maintains+survival+of+melanoblasts+and+melanocyte+stem+cells&rft.au=Moriyama%2C+Mariko%3BOsawa%2C+Masatake%3BMak%2C+Siu-Shan%3BOhtsuka%2C+Toshiyuki%3BYamamoto%2C+Norio%3BHan%2C+Hua%3BDelmas%2C+Veronique%3BKageyama%2C+Ryoichiro%3BBeermann%2C+Friedrich%3BLarue%2C+Lionel%3BNishikawa%2C+Shin-Ichi&rft.aulast=Moriyama&rft.aufirst=Mariko&rft.date=2006-05-08&rft.volume=173&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Molecular modelling; Pigmentation; Data processing; Apoptosis; Survival; Melanocytes; Hair; Notch protein; Stem cells; Transcription factors; NOTCH protein; Cell interactions; Keratinocytes; Signal transduction ER - TY - CPAPER T1 - Role of Nuclear Receptors in Chemical Toxicity and Carcinogenicity T2 - 2006 Keystone Symposia on the Molecular and Integrative Basis for Toxic Responses (Z4) AN - 39171018; 4219754 JF - 2006 Keystone Symposia on the Molecular and Integrative Basis for Toxic Responses (Z4) AU - Gonzalez, Frank J Y1 - 2006/05/07/ PY - 2006 DA - 2006 May 07 KW - Toxicity KW - Carcinogenicity KW - Nuclear receptors KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39171018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+the+Molecular+and+Integrative+Basis+for+Toxic+Responses+%28Z4%29&rft.atitle=Role+of+Nuclear+Receptors+in+Chemical+Toxicity+and+Carcinogenicity&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2006-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+the+Molecular+and+Integrative+Basis+for+Toxic+Responses+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=76 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Observation of Hypernatremia During Sodium Lactate Infusion T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40111791; 4244769 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Xu, Su AU - Zhu, Wenjun AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Sodium lactate KW - Hypernatremia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40111791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=In+Vivo+Observation+of+Hypernatremia+During+Sodium+Lactate+Infusion&rft.au=Xu%2C+Su%3BZhu%2C+Wenjun%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimum Methods for the Preservation of Cartilage Samples in MR Microimaging Studies T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40105981; 4243180 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Canuto, Holly Corianda AU - Fishbein, Kenneth W AU - Bajaj, Preeti AU - Camacho, Nancy P AU - Spencer, Richard G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Preservation KW - Cartilage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40105981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Optimum+Methods+for+the+Preservation+of+Cartilage+Samples+in+MR+Microimaging+Studies&rft.au=Canuto%2C+Holly+Corianda%3BFishbein%2C+Kenneth+W%3BBajaj%2C+Preeti%3BCamacho%2C+Nancy+P%3BSpencer%2C+Richard+G&rft.aulast=Canuto&rft.aufirst=Holly&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Technique for Phase Susceptibility-Weighted Imaging of Iron in the Brain T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40105900; 4244246 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Kotys, Melanie S AU - Thomasson, David M AU - Patronas, Nicholas Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Iron KW - Neuroimaging KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40105900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=A+New+Technique+for+Phase+Susceptibility-Weighted+Imaging+of+Iron+in+the+Brain&rft.au=Kotys%2C+Melanie+S%3BThomasson%2C+David+M%3BPatronas%2C+Nicholas&rft.aulast=Kotys&rft.aufirst=Melanie&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Where in Human Brain is the Representation of Grasping Movements? T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40102048; 4243063 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Hattori, Noriaki AU - Shibasaki, Hiroshi AU - Wheaton, Lewis AU - Wu, Tao AU - Matsuhashi, Masao AU - Hallett, Mark Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Grasping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Where+in+Human+Brain+is+the+Representation+of+Grasping+Movements%3F&rft.au=Hattori%2C+Noriaki%3BShibasaki%2C+Hiroshi%3BWheaton%2C+Lewis%3BWu%2C+Tao%3BMatsuhashi%2C+Masao%3BHallett%2C+Mark&rft.aulast=Hattori&rft.aufirst=Noriaki&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectrally Selective B1 Insensitive T2 Preparation Sequence for 3T Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40101754; 4242804 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Nezafat, Reza AU - Derbyshire, John Andrew AU - Ouwerkerk, Ronald AU - Stuber, Matthias AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Spectrally+Selective+B1+Insensitive+T2+Preparation+Sequence+for+3T+Imaging&rft.au=Nezafat%2C+Reza%3BDerbyshire%2C+John+Andrew%3BOuwerkerk%2C+Ronald%3BStuber%2C+Matthias%3BMcVeigh%2C+Elliot+R&rft.aulast=Nezafat&rft.aufirst=Reza&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Neurodegeneration in a Mouse Model of INCL by MRI and Spectroscopic Analyses T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40100267; 4242861 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Heffer, Alison AU - Munasinghe, Jeeva P AU - Zhang, Zhongjian AU - Hofmann, Sandra L AU - Koretsky, Alan P AU - Mukherjee, Anil Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging KW - Neurodegeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40100267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Evaluation+of+Neurodegeneration+in+a+Mouse+Model+of+INCL+by+MRI+and+Spectroscopic+Analyses&rft.au=Heffer%2C+Alison%3BMunasinghe%2C+Jeeva+P%3BZhang%2C+Zhongjian%3BHofmann%2C+Sandra+L%3BKoretsky%2C+Alan+P%3BMukherjee%2C+Anil&rft.aulast=Heffer&rft.aufirst=Alison&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimal Combination of Phase Cycling and Gradient Spoiling in DENSE Displacement Mapping T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40100225; 4244940 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bennett, Eric AU - Spottiswoode, Bruce AU - Lorenz, Christine H AU - Wen, Han Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40100225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Optimal+Combination+of+Phase+Cycling+and+Gradient+Spoiling+in+DENSE+Displacement+Mapping&rft.au=Bennett%2C+Eric%3BSpottiswoode%2C+Bruce%3BLorenz%2C+Christine+H%3BWen%2C+Han&rft.aulast=Bennett&rft.aufirst=Eric&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimization of 24-Channel Receive-Only Coil Array for Brain Imaging at 7.0 Tesla by the Genetic Algorithm T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40099942; 4245698 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Wang, Shumin AU - Ledden, Patrick J AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Neuroimaging KW - Algorithms KW - Mathematical models KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Optimization+of+24-Channel+Receive-Only+Coil+Array+for+Brain+Imaging+at+7.0+Tesla+by+the+Genetic+Algorithm&rft.au=Wang%2C+Shumin%3BLedden%2C+Patrick+J%3BDuyn%2C+Jeff+H&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Detection of Unobstructed Glutamate and Glutamine using Standard STEAM with Optimized Sequence Parameters at , 4., , and 9.4 Tesla - A Simulation Study T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40099565; 4242700 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Shaolin AU - Hu, Jiani AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Simulation KW - Steam KW - Glutamic acid KW - Glutamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Simultaneous+Detection+of+Unobstructed+Glutamate+and+Glutamine+using+Standard+STEAM+with+Optimized+Sequence+Parameters+at+%2C+4.%2C+%2C+and+9.4+Tesla+-+A+Simulation+Study&rft.au=Yang%2C+Shaolin%3BHu%2C+Jiani%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Lactate Dehydrogenase Reaction In Vivo using Carbon-13 Magnetization Transfer T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40099192; 4242618 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Xu, Su AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Lactate dehydrogenase KW - Lactic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Detection+of+Lactate+Dehydrogenase+Reaction+In+Vivo+using+Carbon-13+Magnetization+Transfer&rft.au=Xu%2C+Su%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantifying the BOLD Contribution in CBV-Weighted fMRI at 9.4T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40096241; 4244452 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Lu, Hanbing AU - Gitajn, Leah AU - Rea, William AU - Yang, Yihong AU - Stein, Elliot A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40096241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Quantifying+the+BOLD+Contribution+in+CBV-Weighted+fMRI+at+9.4T&rft.au=Lu%2C+Hanbing%3BGitajn%2C+Leah%3BRea%2C+William%3BYang%2C+Yihong%3BStein%2C+Elliot+A&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Experimental and Numerical Investigations of SENSE Array Performances from High to Ultra-High Field Strengths T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40096131; 4242625 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Wang, Shumin AU - Ledden, Patrick J AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Koretsky, Alan AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40096131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Experimental+and+Numerical+Investigations+of+SENSE+Array+Performances+from+High+to+Ultra-High+Field+Strengths&rft.au=Wang%2C+Shumin%3BLedden%2C+Patrick+J%3Bde+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BKoretsky%2C+Alan%3BDuyn%2C+Jeff+H&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determining the Latency between Spontaneous Respiration Fluctuations and BOLD Signal Changes T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40095854; 4243763 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Smith, Monica A AU - Bandettini, Peter A AU - Birn, Rasmus M Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Respiration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Determining+the+Latency+between+Spontaneous+Respiration+Fluctuations+and+BOLD+Signal+Changes&rft.au=Smith%2C+Monica+A%3BBandettini%2C+Peter+A%3BBirn%2C+Rasmus+M&rft.aulast=Smith&rft.aufirst=Monica&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Transferrin Receptor and Ferritin Following Ferumoxides - Protamine Sulfate Labeling of Cells: Implications for Cellular Magnetic Resonance Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40095599; 4243371 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Pawelczyk, Edyta AU - Arbab, Ali S AU - Pandit, Sunil AU - Hu, Elbert AU - Frank, Joseph A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Sulfate KW - Magnetic resonance imaging KW - Protamine sulfate KW - Transferrin receptors KW - Ferritin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Expression+of+Transferrin+Receptor+and+Ferritin+Following+Ferumoxides+-+Protamine+Sulfate+Labeling+of+Cells%3A+Implications+for+Cellular+Magnetic+Resonance+Imaging&rft.au=Pawelczyk%2C+Edyta%3BArbab%2C+Ali+S%3BPandit%2C+Sunil%3BHu%2C+Elbert%3BFrank%2C+Joseph+A&rft.aulast=Pawelczyk&rft.aufirst=Edyta&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extension of the Diffusion Orientation Transform (DOT) to Multiexponential Signal Attenuation T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40094845; 4243406 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ozarslan, Evren AU - Vemuri, Baba C AU - Blackband, Stephen J Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40094845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Extension+of+the+Diffusion+Orientation+Transform+%28DOT%29+to+Multiexponential+Signal+Attenuation&rft.au=Ozarslan%2C+Evren%3BVemuri%2C+Baba+C%3BBlackband%2C+Stephen+J&rft.aulast=Ozarslan&rft.aufirst=Evren&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Magnetization Transfer for Early Assessment of Hepatic Tumors Treated with Thermal Ablation T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40094372; 4244182 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Gharib, Ahmed M AU - Kotys, Melanie S AU - Thomasson, David M AU - Locklin, Julia K AU - Wood, Brad J Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Liver KW - Tumors KW - Ablation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40094372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Magnetization+Transfer+for+Early+Assessment+of+Hepatic+Tumors+Treated+with+Thermal+Ablation&rft.au=Gharib%2C+Ahmed+M%3BKotys%2C+Melanie+S%3BThomasson%2C+David+M%3BLocklin%2C+Julia+K%3BWood%2C+Brad+J&rft.aulast=Gharib&rft.aufirst=Ahmed&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Energy Phosphate Abnormalities Normalize After Antipsychotic Treatment in Schizophrenia: A Longitudinal 31P MRS Study of Basal Ganglia T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40093262; 4244417 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Narayan, Jayakumar Peruvumba AU - Gangadhar, B N AU - Venkatasubramanian, G AU - Keshavan, M S Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Neuroleptics KW - Phosphate KW - Schizophrenia KW - Energy KW - Basal ganglia KW - Mental disorders KW - Ganglia KW - Abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40093262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=High+Energy+Phosphate+Abnormalities+Normalize+After+Antipsychotic+Treatment+in+Schizophrenia%3A+A+Longitudinal+31P+MRS+Study+of+Basal+Ganglia&rft.au=Narayan%2C+Jayakumar+Peruvumba%3BGangadhar%2C+B+N%3BVenkatasubramanian%2C+G%3BKeshavan%2C+M+S&rft.aulast=Narayan&rft.aufirst=Jayakumar&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-Time Single-Shot CINE Imaging of Through-Slice Strain in the Human Heart T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40092690; 4244945 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Wen, Han AU - Bennett, Eric Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Heart KW - Strains UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40092690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Real-Time+Single-Shot+CINE+Imaging+of+Through-Slice+Strain+in+the+Human+Heart&rft.au=Wen%2C+Han%3BBennett%2C+Eric&rft.aulast=Wen&rft.aufirst=Han&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of MR Lymphangiography with a G6 Macromolecular Contrast Agent Obtained at 1.5T and 3.0T Systems T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40092274; 4244016 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Hama, Yukihiro AU - Bernardo, Marcelino AU - Koyama, Yoshinori AU - Regino, Celeste A AU - Brechbiel, Martin W AU - Choyke, Peter L AU - Kobayashi, Hisataka Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Contrast media KW - Macromolecules KW - Lymphangiography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40092274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Comparison+of+MR+Lymphangiography+with+a+G6+Macromolecular+Contrast+Agent+Obtained+at+1.5T+and+3.0T+Systems&rft.au=Hama%2C+Yukihiro%3BBernardo%2C+Marcelino%3BKoyama%2C+Yoshinori%3BRegino%2C+Celeste+A%3BBrechbiel%2C+Martin+W%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved DCE-MRI in Bilateral Breast Imaging with Fat Suppressed TRICKS T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40091416; 4244732 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Gai, Neville Dali AU - Saranathan, Manojkumar AU - Gupta, Sandeep AU - Thomasson, David AU - Chow, Catherine Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Breast UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40091416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Improved+DCE-MRI+in+Bilateral+Breast+Imaging+with+Fat+Suppressed+TRICKS&rft.au=Gai%2C+Neville+Dali%3BSaranathan%2C+Manojkumar%3BGupta%2C+Sandeep%3BThomasson%2C+David%3BChow%2C+Catherine&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MR-Guided Evaluation of Post-Infarction Ventricular Tachycardia T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40083208; 4243142 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ashikaga, Hiroshi AU - Hopenfeld, Bruce AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Tachycardia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40083208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=MR-Guided+Evaluation+of+Post-Infarction+Ventricular+Tachycardia&rft.au=Ashikaga%2C+Hiroshi%3BHopenfeld%2C+Bruce%3BMcVeigh%2C+Elliot+R&rft.aulast=Ashikaga&rft.aufirst=Hiroshi&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Multiple Physiologic Parameter Regression Increases Gray Matter Temporal Signal to Noise by Up to 50% T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40082682; 4243019 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Matthias Birn, Rasmus AU - Murphy, Kevin AU - Bodurka, Jerzy AU - Bandettini, Peter Anthony Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Substantia grisea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40082682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Use+of+Multiple+Physiologic+Parameter+Regression+Increases+Gray+Matter+Temporal+Signal+to+Noise+by+Up+to+50%25&rft.au=Matthias+Birn%2C+Rasmus%3BMurphy%2C+Kevin%3BBodurka%2C+Jerzy%3BBandettini%2C+Peter+Anthony&rft.aulast=Matthias+Birn&rft.aufirst=Rasmus&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-Time Tagging of Muscle Dynamics in a 70cm Bore 1.5T Scanner T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40079191; 4245524 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - McVeigh, Elliot AU - Guttman, Mike AU - Ozturk, Cengizhan AU - Blemker, Silvia Salinas Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Muscles KW - Tagging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40079191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Real-Time+Tagging+of+Muscle+Dynamics+in+a+70cm+Bore+1.5T+Scanner&rft.au=McVeigh%2C+Elliot%3BGuttman%2C+Mike%3BOzturk%2C+Cengizhan%3BBlemker%2C+Silvia+Salinas&rft.aulast=McVeigh&rft.aufirst=Elliot&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficient Implementation of Hardware Optimized Gradients for Rapid Imaging Sequences T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40079140; 4245522 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Derbyshire, J Andrew AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40079140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Efficient+Implementation+of+Hardware+Optimized+Gradients+for+Rapid+Imaging+Sequences&rft.au=Derbyshire%2C+J+Andrew%3BMcVeigh%2C+Elliot+R&rft.aulast=Derbyshire&rft.aufirst=J&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Measurement of Unobstructed Glutamate and Glutamine Signals in TE-Averaged PRESS Spectra at 3T using an Optimized Filter Function T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40078122; 4245373 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Shaolin AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Filters KW - Glutamic acid KW - Glutamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Simultaneous+Measurement+of+Unobstructed+Glutamate+and+Glutamine+Signals+in+TE-Averaged+PRESS+Spectra+at+3T+using+an+Optimized+Filter+Function&rft.au=Yang%2C+Shaolin%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sentinel Node Imaging of the Breast in Mice using a Dual-Labeled Nano-Sized MRI/near Infrared (NIR) Optical Hybrid Contrast Agent, G6 Cy5.5 T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40074682; 4243372 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Kobayashi, Hisataka AU - Talanov, Vladimir S AU - Bernardo, Marcelino AU - Regino, Celeste A AU - Koyama, Yoshinori AU - Hama, Yukihiro AU - Brechbiel, Martin W AU - Choyke, Peter L Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Mice KW - Magnetic resonance imaging KW - Contrast media KW - Hybrids KW - Breast KW - Nodes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40074682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Sentinel+Node+Imaging+of+the+Breast+in+Mice+using+a+Dual-Labeled+Nano-Sized+MRI%2Fnear+Infrared+%28NIR%29+Optical+Hybrid+Contrast+Agent%2C+G6+Cy5.5&rft.au=Kobayashi%2C+Hisataka%3BTalanov%2C+Vladimir+S%3BBernardo%2C+Marcelino%3BRegino%2C+Celeste+A%3BKoyama%2C+Yoshinori%3BHama%2C+Yukihiro%3BBrechbiel%2C+Martin+W%3BChoyke%2C+Peter+L&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Dependence of BOLD fMRI and Somatosensory Evoked Potentials on Stimulation of the Rat Forepaw with Various Pulse Waveforms T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40074102; 4243585 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Goloshevsky, Artem G AU - Silva, Afonso C AU - Dodd, Stephen J AU - Koretsky, Alan P Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Somatosensory evoked potentials KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40074102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Dependence+of+BOLD+fMRI+and+Somatosensory+Evoked+Potentials+on+Stimulation+of+the+Rat+Forepaw+with+Various+Pulse+Waveforms&rft.au=Goloshevsky%2C+Artem+G%3BSilva%2C+Afonso+C%3BDodd%2C+Stephen+J%3BKoretsky%2C+Alan+P&rft.aulast=Goloshevsky&rft.aufirst=Artem&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Cerebrovascular Coupling under COX-2 Blockade T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40073853; 4243496 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Stefanovic, Bojana AU - Bosetti, Francesca AU - Silva, Afonso C Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Cyclooxygenase-2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Cerebrovascular+Coupling+under+COX-2+Blockade&rft.au=Stefanovic%2C+Bojana%3BBosetti%2C+Francesca%3BSilva%2C+Afonso+C&rft.aulast=Stefanovic&rft.aufirst=Bojana&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Glycine Substitutions in the Amino End of Type I Collagen by Biochemical Screening of Fibroblast Collagen Requires Supplementation by Direct Sequencing for Osteogenesis Imperfecta Probands T2 - 38th European Human Genetics Conference (EHGC 2006) AN - 40073562; 4227454 JF - 38th European Human Genetics Conference (EHGC 2006) AU - Cabral, W A AU - Milgrom, S AU - Letocha, A D AU - Moriarty, E AU - Marini, J C Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Fibroblasts KW - Glycine KW - Collagen (type I) KW - Supplementation KW - Osteogenesis imperfecta KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.atitle=Detection+of+Glycine+Substitutions+in+the+Amino+End+of+Type+I+Collagen+by+Biochemical+Screening+of+Fibroblast+Collagen+Requires+Supplementation+by+Direct+Sequencing+for+Osteogenesis+Imperfecta+Probands&rft.au=Cabral%2C+W+A%3BMilgrom%2C+S%3BLetocha%2C+A+D%3BMoriarty%2C+E%3BMarini%2C+J+C&rft.aulast=Cabral&rft.aufirst=W&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={99CE444B -70A1-45CB-8214-8005F05A6519}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Exchange Rate Measurement using CUPS, A Novel Method for Kinetic Analysis T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40072811; 4243730 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Galban, Craig J AU - Spencer, Richard G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Kinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40072811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Accuracy+of+Exchange+Rate+Measurement+using+CUPS%2C+A+Novel+Method+for+Kinetic+Analysis&rft.au=Galban%2C+Craig+J%3BSpencer%2C+Richard+G&rft.aulast=Galban&rft.aufirst=Craig&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Frequency Profile of TE-Dependent BOLD Physiological Fluctuations T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40063948; 4243015 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Murphy, Kevin AU - Birn, Rasmus M AU - Bandettini, Peter A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40063948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Frequency+Profile+of+TE-Dependent+BOLD+Physiological+Fluctuations&rft.au=Murphy%2C+Kevin%3BBirn%2C+Rasmus+M%3BBandettini%2C+Peter+A&rft.aulast=Murphy&rft.aufirst=Kevin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatio-Temporal Characteristics of Correlated Brain Activity During Awake Rest and Early Sleep T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40063621; 4243027 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Fukunaga, Masaki AU - Horovitz, Silvina G AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Fulton, Susan C AU - Balkin, Thomas J AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Sleep UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40063621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Spatio-Temporal+Characteristics+of+Correlated+Brain+Activity+During+Awake+Rest+and+Early+Sleep&rft.au=Fukunaga%2C+Masaki%3BHorovitz%2C+Silvina+G%3Bde+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BFulton%2C+Susan+C%3BBalkin%2C+Thomas+J%3BDuyn%2C+Jeff+H&rft.aulast=Fukunaga&rft.aufirst=Masaki&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simple Model to Describe Weisskoff EPI Temporal Stability Test - Analogy with Physiological Noise Model in Oxygenation-Sensitive fMRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40063568; 4243022 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bodurka, Jerzy AU - Bandettini, Peter Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Physiology KW - Models KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40063568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Simple+Model+to+Describe+Weisskoff+EPI+Temporal+Stability+Test+-+Analogy+with+Physiological+Noise+Model+in+Oxygenation-Sensitive+fMRI&rft.au=Bodurka%2C+Jerzy%3BBandettini%2C+Peter&rft.aulast=Bodurka&rft.aufirst=Jerzy&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Resolution 3-D Imaging of Chronic Total Occlusions in Peripheral Vessels Using a T-1 Weighted Turbo Spin Echo Sequence with Inner Volume Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40062370; 4245772 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Sampath, Smita AU - Raval, Amish N AU - Lederman, Robert J AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Occlusion KW - Turbo UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40062370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=High-Resolution+3-D+Imaging+of+Chronic+Total+Occlusions+in+Peripheral+Vessels+Using+a+T-1+Weighted+Turbo+Spin+Echo+Sequence+with+Inner+Volume+Imaging&rft.au=Sampath%2C+Smita%3BRaval%2C+Amish+N%3BLederman%2C+Robert+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Simple B@@d1@ Correction Method for High Resolution Neuroimaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40060272; 4245461 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - van Gelderen, Peter AU - Koretsky, Alan P AU - de Zwart, Jacco A AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Neuroimaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=A+Simple+B%40%40d1%40+Correction+Method+for+High+Resolution+Neuroimaging&rft.au=van+Gelderen%2C+Peter%3BKoretsky%2C+Alan+P%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=van+Gelderen&rft.aufirst=Peter&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Method using a Single Selective Editing Pulse for In Vivo Glutathione Editing at 3 Tesla T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40059827; 4245362 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Zhang, Yan AU - Marenco, Stefano AU - Weinberger, Daniel R AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Glutathione KW - Coenzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40059827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=A+Novel+Method+using+a+Single+Selective+Editing+Pulse+for+In+Vivo+Glutathione+Editing+at+3+Tesla&rft.au=Zhang%2C+Yan%3BMarenco%2C+Stefano%3BWeinberger%2C+Daniel+R%3BShen%2C+Jun&rft.aulast=Zhang&rft.aufirst=Yan&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Positive Contrast Susceptibility Weighted Imaging of Physiologic Calcification in Humans T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40059376; 4242891 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Butman, John A AU - Liu, Wei AU - Schaeffter, Tobias Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Calcification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40059376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Positive+Contrast+Susceptibility+Weighted+Imaging+of+Physiologic+Calcification+in+Humans&rft.au=Butman%2C+John+A%3BLiu%2C+Wei%3BSchaeffter%2C+Tobias&rft.aulast=Butman&rft.aufirst=John&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Formalin Fixation and Crosslinking on MRI Contrast in Bovine Nasal Cartilage Explants T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40056577; 4243181 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Fishbein, Kenneth W AU - Gluzband, Yehezkiel A AU - Kaku, Masaru AU - Togore, Hasina AU - Shapses, Sue A AU - Yamauchi, Mitsuo AU - Spencer, Richard G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging KW - Explants KW - Cartilage KW - Formaldehyde UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40056577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Effects+of+Formalin+Fixation+and+Crosslinking+on+MRI+Contrast+in+Bovine+Nasal+Cartilage+Explants&rft.au=Fishbein%2C+Kenneth+W%3BGluzband%2C+Yehezkiel+A%3BKaku%2C+Masaru%3BTogore%2C+Hasina%3BShapses%2C+Sue+A%3BYamauchi%2C+Mitsuo%3BSpencer%2C+Richard+G&rft.aulast=Fishbein&rft.aufirst=Kenneth&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Accurately can the Diffusion Profiles Predict Multiple Fiber Orientations? - A Study on General Fiber Crossings in Diffusion MRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40056360; 4243334 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Zhan, Wang AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Fibers KW - Diffusion KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40056360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=How+Accurately+can+the+Diffusion+Profiles+Predict+Multiple+Fiber+Orientations%3F+-+A+Study+on+General+Fiber+Crossings+in+Diffusion+MRI&rft.au=Zhan%2C+Wang%3BYang%2C+Yihong&rft.aulast=Zhan&rft.aufirst=Wang&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age Dependence of Water Diffusivity in Human Skeletal Muscle T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40054509; 4242468 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Galban, Craig J AU - Maderwald, Stefan AU - Stock, Frank AU - Brauck, Katja AU - Ladd, Mark E Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Skeletal muscle KW - Diffusion coefficients UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40054509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Age+Dependence+of+Water+Diffusivity+in+Human+Skeletal+Muscle&rft.au=Galban%2C+Craig+J%3BMaderwald%2C+Stefan%3BStock%2C+Frank%3BBrauck%2C+Katja%3BLadd%2C+Mark+E&rft.aulast=Galban&rft.aufirst=Craig&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fusion of Delayed Hyperenhancement MRI with Live X-Ray Imaging for Guidance of Targeted Endomyocardial Injections of Therapeutic Cells T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40054161; 4242482 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Gutierrez, Luis F AU - de Silva, Ranil AU - Raval, Amish N AU - Ban, Naheed AU - McVeigh, Elliot R AU - Ozturk, Cengizhan AU - Lederman, Robert J Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40054161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Fusion+of+Delayed+Hyperenhancement+MRI+with+Live+X-Ray+Imaging+for+Guidance+of+Targeted+Endomyocardial+Injections+of+Therapeutic+Cells&rft.au=Gutierrez%2C+Luis+F%3Bde+Silva%2C+Ranil%3BRaval%2C+Amish+N%3BBan%2C+Naheed%3BMcVeigh%2C+Elliot+R%3BOzturk%2C+Cengizhan%3BLederman%2C+Robert+J&rft.aulast=Gutierrez&rft.aufirst=Luis&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Manganese Enhanced MRI to Reveal Active Olfactory Circuitry in Response to Odorant Stimuli T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40053964; 4242439 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Chuang, Kai-Hsiang AU - Lee, Jung Hee AU - Silva, Afonso C AU - Belluscio, Leonardo AU - Koretsky, Alan P Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Odors KW - Manganese KW - Magnetic resonance imaging KW - Odorants KW - Olfaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40053964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Using+Manganese+Enhanced+MRI+to+Reveal+Active+Olfactory+Circuitry+in+Response+to+Odorant+Stimuli&rft.au=Chuang%2C+Kai-Hsiang%3BLee%2C+Jung+Hee%3BSilva%2C+Afonso+C%3BBelluscio%2C+Leonardo%3BKoretsky%2C+Alan+P&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging of Myocardial Edema and Function at High Resolution with T2-Meta-DENSE: The Hypokinetic Zone Corresponds to the Area of Edema T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40053516; 4244112 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Aletras, Anthony Homer AU - Tilak, Gauri S AU - Arai, Andrew Ernest Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Edema KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40053516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Imaging+of+Myocardial+Edema+and+Function+at+High+Resolution+with+T2-Meta-DENSE%3A+The+Hypokinetic+Zone+Corresponds+to+the+Area+of+Edema&rft.au=Aletras%2C+Anthony+Homer%3BTilak%2C+Gauri+S%3BArai%2C+Andrew+Ernest&rft.aulast=Aletras&rft.aufirst=Anthony&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Compatibility of Iron Nanoparticle-Based MRI Cell Tracking and 31P MRS Bioenergetic Measurements T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40053163; 4245161 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Zhang, Zhuoli AU - Fishbein, Kenneth W AU - Dell'Agnola, Chiara AU - Sollott, Steven J AU - Boheler, Kenneth R AU - Juhaszova, Magdalena AU - Lakatta, Edward G AU - Spencer, Richard G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Iron KW - Magnetic resonance imaging KW - Bioenergetics KW - Tracking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40053163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Compatibility+of+Iron+Nanoparticle-Based+MRI+Cell+Tracking+and+31P+MRS+Bioenergetic+Measurements&rft.au=Zhang%2C+Zhuoli%3BFishbein%2C+Kenneth+W%3BDell%27Agnola%2C+Chiara%3BSollott%2C+Steven+J%3BBoheler%2C+Kenneth+R%3BJuhaszova%2C+Magdalena%3BLakatta%2C+Edward+G%3BSpencer%2C+Richard+G&rft.aulast=Zhang&rft.aufirst=Zhuoli&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Characterization of Vascular Non-Linearities in BOLD fMRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40052671; 4244363 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Jansma, J Martijn AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Vascular system KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40052671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Quantitative+Characterization+of+Vascular+Non-Linearities+in+BOLD+fMRI&rft.au=de+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BJansma%2C+J+Martijn%3BDuyn%2C+Jeff+H&rft.aulast=de+Zwart&rft.aufirst=Jacco&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CASL Perfusion MRI with Non-Segmented Low Flip Angle 3D EPI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40052393; 4243920 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Talagala, S L AU - Slavin, G S AU - Ostuni, J AU - Chesnick, S Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging KW - Perfusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40052393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=CASL+Perfusion+MRI+with+Non-Segmented+Low+Flip+Angle+3D+EPI&rft.au=Talagala%2C+S+L%3BSlavin%2C+G+S%3BOstuni%2C+J%3BChesnick%2C+S&rft.aulast=Talagala&rft.aufirst=S&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Error Propagation Framework for Diffusion Tensor Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40048584; 4242995 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Koay, Cheng Guan AU - Chang, Lin-Ching AU - Pierpaoli, Carlo AU - Basser, Peter J Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40048584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Error+Propagation+Framework+for+Diffusion+Tensor+Imaging&rft.au=Koay%2C+Cheng+Guan%3BChang%2C+Lin-Ching%3BPierpaoli%2C+Carlo%3BBasser%2C+Peter+J&rft.aulast=Koay&rft.aufirst=Cheng&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase Susceptibility-Weighted Imaging of SPIO Nanoparticles T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40047044; 4245099 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Kotys, Melanie S AU - Fung, Steve H AU - Xie, Jianwu AU - Li, King C.P. Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Nanoparticles KW - Spio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40047044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Phase+Susceptibility-Weighted+Imaging+of+SPIO+Nanoparticles&rft.au=Kotys%2C+Melanie+S%3BFung%2C+Steve+H%3BXie%2C+Jianwu%3BLi%2C+King+C.P.&rft.aulast=Kotys&rft.aufirst=Melanie&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Coupling between BOLD, CBF, CBV, and SEP Responses under NO Blockade T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40046220; 4243497 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Stefanovic, Bojana AU - Schwindt, Wolfram AU - Hoehn, Mathias AU - Silva, Afonso C Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Cerebral blood flow KW - Somatosensory evoked potentials KW - Nitric oxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40046220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Coupling+between+BOLD%2C+CBF%2C+CBV%2C+and+SEP+Responses+under+NO+Blockade&rft.au=Stefanovic%2C+Bojana%3BSchwindt%2C+Wolfram%3BHoehn%2C+Mathias%3BSilva%2C+Afonso+C&rft.aulast=Stefanovic&rft.aufirst=Bojana&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T@@d1@ Measurements at 7T with Application to Tissue Specific Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40045126; 4243610 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ikonomidou, Vasiliki N AU - van Gelderen, Peter AU - de Zwart, Jacco A AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40045126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=T%40%40d1%40+Measurements+at+7T+with+Application+to+Tissue+Specific+Imaging&rft.au=Ikonomidou%2C+Vasiliki+N%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Ikonomidou&rft.aufirst=Vasiliki&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Skeletal Muscle Injury with Gadomer T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40044254; 4244121 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Faranesh, Anthony Z AU - Kraitchman, Dara L AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Skeletal muscle KW - Injuries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40044254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Measurement+of+Skeletal+Muscle+Injury+with+Gadomer&rft.au=Faranesh%2C+Anthony+Z%3BKraitchman%2C+Dara+L%3BMcVeigh%2C+Elliot+R&rft.aulast=Faranesh&rft.aufirst=Anthony&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging 2-D Myocardial Motion and Chamber Blood Flow Simultaneously with EGGS SPAMM & SPAMM (Encoded Gradients for Gauging Speed in Sinusoidal SPAMM and Co-Sinusoidal SPAMM Acquisitions) T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40040053; 4244086 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Sampath, Smita AU - McVeigh, Elliot R Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Blood circulation KW - Eggs KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Imaging+2-D+Myocardial+Motion+and+Chamber+Blood+Flow+Simultaneously+with+EGGS+SPAMM+%26amp%3B+SPAMM+%28Encoded+Gradients+for+Gauging+Speed+in+Sinusoidal+SPAMM+and+Co-Sinusoidal+SPAMM+Acquisitions%29&rft.au=Sampath%2C+Smita%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Visualization of Cytoarchitecture to Define Boundaries in Cortex, Thalamic Nuclei and Superior Colliculus using Manganese Enhanced MRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40039257; 4242434 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Wu, Carolyn W.-H. AU - Dodd, Stephen J AU - Koretsky, Alan P Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Manganese KW - Superior colliculus KW - Brain architecture KW - Magnetic resonance imaging KW - Thalamic nuclei KW - Cortex KW - Boundaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40039257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=In+Vivo+Visualization+of+Cytoarchitecture+to+Define+Boundaries+in+Cortex%2C+Thalamic+Nuclei+and+Superior+Colliculus+using+Manganese+Enhanced+MRI&rft.au=Wu%2C+Carolyn+W.-H.%3BDodd%2C+Stephen+J%3BKoretsky%2C+Alan+P&rft.aulast=Wu&rft.aufirst=Carolyn&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Dynamic Water Diffusion Process Inside Human Brain Based on Numerical Solution of the Diffusion Equation T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40039222; 4244321 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Zhan, Wang AU - Jiang, Li AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion KW - Brain mapping KW - Mathematical models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40039222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Mapping+Dynamic+Water+Diffusion+Process+Inside+Human+Brain+Based+on+Numerical+Solution+of+the+Diffusion+Equation&rft.au=Zhan%2C+Wang%3BJiang%2C+Li%3BYang%2C+Yihong&rft.aulast=Zhan&rft.aufirst=Wang&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hunting for Cerebral [2-@@u13@C]GABA Signal Derived In Vivo from Glia-Specific Substrate [2-@@u13@C]Acetate T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40038380; 4242799 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Jehoon AU - Li, Shizhe Steve AU - Fox, Stephen AU - Bacher, John AU - Innis, Robert B AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Hunting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40038380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Hunting+for+Cerebral+%5B2-%40%40u13%40C%5DGABA+Signal+Derived+In+Vivo+from+Glia-Specific+Substrate+%5B2-%40%40u13%40C%5DAcetate&rft.au=Yang%2C+Jehoon%3BLi%2C+Shizhe+Steve%3BFox%2C+Stephen%3BBacher%2C+John%3BInnis%2C+Robert+B%3BShen%2C+Jun&rft.aulast=Yang&rft.aufirst=Jehoon&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Resting-State Functional Connectivity by Perfusion MRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40038136; 4242742 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Chuang, Kai-Hsiang AU - van Gelderen, Peter AU - Bodurka, Jerzy AU - Ikonomidou, Vasiliki AU - Koretsky, Alan AU - Duyn, Jeff AU - Talagala, S Lalith Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Mapping KW - Magnetic resonance imaging KW - Perfusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40038136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Mapping+Resting-State+Functional+Connectivity+by+Perfusion+MRI&rft.au=Chuang%2C+Kai-Hsiang%3Bvan+Gelderen%2C+Peter%3BBodurka%2C+Jerzy%3BIkonomidou%2C+Vasiliki%3BKoretsky%2C+Alan%3BDuyn%2C+Jeff%3BTalagala%2C+S+Lalith&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of VEGF in Growth of Brain Metastases from Single Cells as Visualized by Contrast Enhanced MRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40037777; 4242674 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Tracy, Kirsten AU - Yin, Juan Juan AU - Munasinghe, Jeeva AU - Shaprio, Erik AU - Koretsky, Alan AU - Kelly, Kathleen Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Magnetic resonance imaging KW - Vascular endothelial growth factor KW - Metastases KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Role+of+VEGF+in+Growth+of+Brain+Metastases+from+Single+Cells+as+Visualized+by+Contrast+Enhanced+MRI&rft.au=Tracy%2C+Kirsten%3BYin%2C+Juan+Juan%3BMunasinghe%2C+Jeeva%3BShaprio%2C+Erik%3BKoretsky%2C+Alan%3BKelly%2C+Kathleen&rft.aulast=Tracy&rft.aufirst=Kirsten&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T@@d1@ Tissue Specific Imaging in Multiple Sclerosis: Sensitivity and Specificity Issues T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40037691; 4242652 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ikonomidou, Vasiliki N AU - Bagnato, Francesca AU - van Gelderen, Peter AU - Riva, Marco AU - Tovar-Moll, Fernanda AU - de Zwart, Jacco A AU - Horovitz, Silvina G AU - Ohayon, Joan AU - McFarland, Henry F AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques KW - Multiple sclerosis KW - Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=T%40%40d1%40+Tissue+Specific+Imaging+in+Multiple+Sclerosis%3A+Sensitivity+and+Specificity+Issues&rft.au=Ikonomidou%2C+Vasiliki+N%3BBagnato%2C+Francesca%3Bvan+Gelderen%2C+Peter%3BRiva%2C+Marco%3BTovar-Moll%2C+Fernanda%3Bde+Zwart%2C+Jacco+A%3BHorovitz%2C+Silvina+G%3BOhayon%2C+Joan%3BMcFarland%2C+Henry+F%3BDuyn%2C+Jeff+H&rft.aulast=Ikonomidou&rft.aufirst=Vasiliki&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interest in Genetic Susceptibility Testing for Lung Cancer: Seeking Motivation to Quit or an Excuse to Continue Smoking? T2 - 2006 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2006) AN - 40034704; 4227574 JF - 2006 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2006) AU - McBride, C AU - Page, Z AU - White, D B AU - Martin, J C AU - Lipkus, I M AU - Bastian, L AU - Bepler, G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Smoking KW - Lung cancer KW - Motivation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40034704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2006%29&rft.atitle=Interest+in+Genetic+Susceptibility+Testing+for+Lung+Cancer%3A+Seeking+Motivation+to+Quit+or+an+Excuse+to+Continue+Smoking%3F&rft.au=McBride%2C+C%3BPage%2C+Z%3BWhite%2C+D+B%3BMartin%2C+J+C%3BLipkus%2C+I+M%3BBastian%2C+L%3BBepler%2C+G&rft.aulast=McBride&rft.aufirst=C&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={99CE444B-70A1-45CB-8214-8 005F05A6519} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MR Studies of Aging in the Hippocampus of the FBNF1 Rat Show Correlations with Behavioral and Structural Degeneration T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40027998; 4244768 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Driscoll, Ira AU - Sutherland, Robert S AU - Tomanek, Boguslaw AU - Dunn, Jeff F AU - Brooks, William M Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Aging KW - Degeneration KW - Hippocampus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=MR+Studies+of+Aging+in+the+Hippocampus+of+the+FBNF1+Rat+Show+Correlations+with+Behavioral+and+Structural+Degeneration&rft.au=Driscoll%2C+Ira%3BSutherland%2C+Robert+S%3BTomanek%2C+Boguslaw%3BDunn%2C+Jeff+F%3BBrooks%2C+William+M&rft.aulast=Driscoll&rft.aufirst=Ira&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Cocaine-Induced Brain Activation using Manganese-Enhanced MRI T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40024385; 4245440 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Lu, Hanbing AU - Xi, Zheng-Xiong AU - Gitajn, Leah AU - Rea, William AU - Scholl, Clara AU - Yang, Yihong AU - Stein, Elliot A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain mapping KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40024385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Mapping+Cocaine-Induced+Brain+Activation+using+Manganese-Enhanced+MRI&rft.au=Lu%2C+Hanbing%3BXi%2C+Zheng-Xiong%3BGitajn%2C+Leah%3BRea%2C+William%3BScholl%2C+Clara%3BYang%2C+Yihong%3BStein%2C+Elliot+A&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effectiveness of a Biomaterial Adhesive in Integrating a Hydrogel with Surrounding Tissue in Rabbit Cartilage Defects T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40015364; 4243182 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ramaswamy, Sharan AU - Gurkan, Ilksen AU - Sharma, Blanka AU - Fishbein, Kenneth W AU - Cascio, Brett AU - Elisseeff, Jennifer AU - Spencer, Richard G Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Adhesives KW - Cartilage KW - Hydrogels KW - Biomaterials KW - Defects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40015364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Effectiveness+of+a+Biomaterial+Adhesive+in+Integrating+a+Hydrogel+with+Surrounding+Tissue+in+Rabbit+Cartilage+Defects&rft.au=Ramaswamy%2C+Sharan%3BGurkan%2C+Ilksen%3BSharma%2C+Blanka%3BFishbein%2C+Kenneth+W%3BCascio%2C+Brett%3BElisseeff%2C+Jennifer%3BSpencer%2C+Richard+G&rft.aulast=Ramaswamy&rft.aufirst=Sharan&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Magnetization Transfer of Liver at 3T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40012867; 4244611 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Kotys, Melanie S AU - Gharib, Ahmed M Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=In+Vivo+Magnetization+Transfer+of+Liver+at+3T&rft.au=Kotys%2C+Melanie+S%3BGharib%2C+Ahmed+M&rft.aulast=Kotys&rft.aufirst=Melanie&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification and Mapping of T@@d1@ Relaxation Time in the Tongue T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40012001; 4245609 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Evangelou, Iordanis Evangelou AU - Chi-Fishman, Gloria Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Mapping KW - Tongue UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Quantification+and+Mapping+of+T%40%40d1%40+Relaxation+Time+in+the+Tongue&rft.au=Evangelou%2C+Iordanis+Evangelou%3BChi-Fishman%2C+Gloria&rft.aulast=Evangelou&rft.aufirst=Iordanis&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional MRI Incorporating Information on Voxel-Wise Tissue Volume Fractions T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40011378; 4244725 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Yihong AU - Zhan, Wang AU - Gu, Hong AU - Stein, Elliot A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40011378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Functional+MRI+Incorporating+Information+on+Voxel-Wise+Tissue+Volume+Fractions&rft.au=Yang%2C+Yihong%3BZhan%2C+Wang%3BGu%2C+Hong%3BStein%2C+Elliot+A&rft.aulast=Yang&rft.aufirst=Yihong&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulating the SNR of High-Field RF Coils by the Surface Integral-Equation Method T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40006749; 4243396 DE: JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Wang, Shumin AU - Ledden, Patrick J AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Simulating+the+SNR+of+High-Field+RF+Coils+by+the+Surface+Integral-Equation+Method&rft.au=Wang%2C+Shumin%3BLedden%2C+Patrick+J%3BDuyn%2C+Jeff+H&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Temporal and Spatial Resolution In Vivo Oxymetry using Time-Domain EPR Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40006390; 4243600 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Subramanian, Sankaran AU - Matsumoto, Ken-Ichiro AU - Hyodo, Fuminori AU - Devasahayam, Nallathamby AU - Johnson, Calvin A AU - Mitchell, James B AU - Krishna, Cherukuri M Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Improved+Temporal+and+Spatial+Resolution+In+Vivo+Oxymetry+using+Time-Domain+EPR+Imaging&rft.au=Subramanian%2C+Sankaran%3BMatsumoto%2C+Ken-Ichiro%3BHyodo%2C+Fuminori%3BDevasahayam%2C+Nallathamby%3BJohnson%2C+Calvin+A%3BMitchell%2C+James+B%3BKrishna%2C+Cherukuri+M&rft.aulast=Subramanian&rft.aufirst=Sankaran&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T2* Measurement during First-Pass Contrast Enhanced Cardiac Perfusion Imaging T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40003205; 4244076 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Kellman, Peter AU - Aletras, Anthony H AU - Hsu, Li-yueh AU - McVeigh, Elliot R AU - Arai, Andrew E Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Perfusion KW - Imaging techniques KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=T2*+Measurement+during+First-Pass+Contrast+Enhanced+Cardiac+Perfusion+Imaging&rft.au=Kellman%2C+Peter%3BAletras%2C+Anthony+H%3BHsu%2C+Li-yueh%3BMcVeigh%2C+Elliot+R%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Global Cerebral Vasodilation on Focal Activation Hemodynamics T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40001936; 4244377 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Stefanovic, Bojana AU - Warnking, Jan M AU - Rylander, Karin M AU - Pike, Bruce Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Hemodynamics KW - Vasodilation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40001936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Effect+of+Global+Cerebral+Vasodilation+on+Focal+Activation+Hemodynamics&rft.au=Stefanovic%2C+Bojana%3BWarnking%2C+Jan+M%3BRylander%2C+Karin+M%3BPike%2C+Bruce&rft.aulast=Stefanovic&rft.aufirst=Bojana&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Connectivity in the Resting Brain Revealed by Group-Level Independent Component Analysis T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39998288; 4243017 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Chen, Sharon AU - Ross, Thomas J AU - Chuang, Keh-Shih AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Neural networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Functional+Connectivity+in+the+Resting+Brain+Revealed+by+Group-Level+Independent+Component+Analysis&rft.au=Chen%2C+Sharon%3BRoss%2C+Thomas+J%3BChuang%2C+Keh-Shih%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Chen&rft.aufirst=Sharon&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inductive Decoupling of RF Coil Arrays: A Study at 7T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39995831; 4245696 DE: JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - do Nascimento, George Carlos AU - Paiva, Fernando F AU - Silva, Afonso Costa Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Inductive+Decoupling+of+RF+Coil+Arrays%3A+A+Study+at+7T&rft.au=do+Nascimento%2C+George+Carlos%3BPaiva%2C+Fernando+F%3BSilva%2C+Afonso+Costa&rft.aulast=do+Nascimento&rft.aufirst=George&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Carbon-13 Spectroscopy of Rhesus Monkey Brain at 4.7T: Detecting Rapid Exchange between α-Ketoglutarate and Glutamate using Magnetization Transfer T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39995773; 4245651 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Li, Shizhe Steve AU - Yang, Jehoo AU - Chen, Zhengguang AU - Bacher, John AU - Innis, Robert B AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Spectroscopy KW - Brain KW - Glutamic acid KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=In+Vivo+Carbon-13+Spectroscopy+of+Rhesus+Monkey+Brain+at+4.7T%3A+Detecting+Rapid+Exchange+between+%CE%B1-Ketoglutarate+and+Glutamate+using+Magnetization+Transfer&rft.au=Li%2C+Shizhe+Steve%3BYang%2C+Jehoo%3BChen%2C+Zhengguang%3BBacher%2C+John%3BInnis%2C+Robert+B%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further Evidence for a Correlation between Increased Endogenous GABA Concentration and Decreased Glutamate-Glutamine Cycling Flux T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39994025; 4245363 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Jehoon AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - ^g-Aminobutyric acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Further+Evidence+for+a+Correlation+between+Increased+Endogenous+GABA+Concentration+and+Decreased+Glutamate-Glutamine+Cycling+Flux&rft.au=Yang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Yang&rft.aufirst=Jehoon&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From ADC to Probability Profiles: The Diffusion Orientation Transform T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39993836; 4242956 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ozarslan, Evren AU - Shepherd, Timothy M AU - Vemuri, Baba C AU - Blackband, Stephen J AU - Mareci, Thomas H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=From+ADC+to+Probability+Profiles%3A+The+Diffusion+Orientation+Transform&rft.au=Ozarslan%2C+Evren%3BShepherd%2C+Timothy+M%3BVemuri%2C+Baba+C%3BBlackband%2C+Stephen+J%3BMareci%2C+Thomas+H&rft.aulast=Ozarslan&rft.aufirst=Evren&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Detection of Dynamic @@u13@C Isotopomer Turnover from [ U-@@u13@C]-Glucose T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39992700; 4242348 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Xu, Su AU - Zhu, Wenjun AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Animal models KW - Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=In+Vivo+Detection+of+Dynamic+%40%40u13%40C+Isotopomer+Turnover+from+%5B+U-%40%40u13%40C%5D-Glucose&rft.au=Xu%2C+Su%3BZhu%2C+Wenjun%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Contrast Enhanced Imaging and Quantitative Analysis of Prostate Cancer at 3 Tesla T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39992513; 4242303 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ocak, Iclal AU - Bernardo, Marcelino AU - Metzger, Gregory AU - McKinney, Yolanda AU - Choyke, Peter Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Prostate cancer KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Dynamic+Contrast+Enhanced+Imaging+and+Quantitative+Analysis+of+Prostate+Cancer+at+3+Tesla&rft.au=Ocak%2C+Iclal%3BBernardo%2C+Marcelino%3BMetzger%2C+Gregory%3BMcKinney%2C+Yolanda%3BChoyke%2C+Peter&rft.aulast=Ocak&rft.aufirst=Iclal&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resting-State Functional Connectivity in Rat Brain T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39991037; 4242740 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Lu, Hanbing AU - Gitajn, Leah AU - Rea, William AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Neural networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Resting-State+Functional+Connectivity+in+Rat+Brain&rft.au=Lu%2C+Hanbing%3BGitajn%2C+Leah%3BRea%2C+William%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Residual Water as a Navigator in GABA Editing Spectroscopy T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39990967; 4242698 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - van der Veen, Jan Willem W.C. AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Spectroscopy KW - ^g-Aminobutyric acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39990967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Residual+Water+as+a+Navigator+in+GABA+Editing+Spectroscopy&rft.au=van+der+Veen%2C+Jan+Willem+W.C.%3BShen%2C+Jun&rft.aulast=van+der+Veen&rft.aufirst=Jan+Willem&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consortium for Osteogenesis Imperfecta Mutations: Lethal Regions in the Helical Portion of Type I Collagen Chains Align with Collagen Binding Sites for Integrin and Proteoglycans T2 - 38th European Human Genetics Conference (EHGC 2006) AN - 39987180; 4227030 JF - 38th European Human Genetics Conference (EHGC 2006) AU - Marini, J C AU - Forlino, A AU - Cabral, W AU - Barnes, A AU - Antonio, J San AU - Milgrom, S AU - Hyland, J AU - Korkko, J AU - Prockop, D AU - Depaepe, A AU - Coucke, P AU - Glorieux, F AU - Roughley, P AU - Lund, A AU - Kuurila, K AU - Cohn, D AU - Krakow, D AU - Mottes, M AU - Schwarze, U AU - Troendle, J AU - Dalgleish, R AU - Byers, P Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Mutation KW - Collagen (type I) KW - Osteogenesis imperfecta KW - Proteoglycans KW - Integrins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.atitle=Consortium+for+Osteogenesis+Imperfecta+Mutations%3A+Lethal+Regions+in+the+Helical+Portion+of+Type+I+Collagen+Chains+Align+with+Collagen+Binding+Sites+for+Integrin+and+Proteoglycans&rft.au=Marini%2C+J+C%3BForlino%2C+A%3BCabral%2C+W%3BBarnes%2C+A%3BAntonio%2C+J+San%3BMilgrom%2C+S%3BHyland%2C+J%3BKorkko%2C+J%3BProckop%2C+D%3BDepaepe%2C+A%3BCoucke%2C+P%3BGlorieux%2C+F%3BRoughley%2C+P%3BLund%2C+A%3BKuurila%2C+K%3BCohn%2C+D%3BKrakow%2C+D%3BMottes%2C+M%3BSchwarze%2C+U%3BTroendle%2C+J%3BDalgleish%2C+R%3BByers%2C+P&rft.aulast=Marini&rft.aufirst=J&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={99CE444B -70A1-45CB-8214-8005F05A6519}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BOLD fMRI Resting State Activity and the Network of Default Mode Brain Function T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39986007; 4242739 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Horovitz, Silvina G AU - Fukunaga, Masaki AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Fulton, Susan C AU - Balkin, Thomas J AU - Duyn, Jeff H Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39986007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=BOLD+fMRI+Resting+State+Activity+and+the+Network+of+Default+Mode+Brain+Function&rft.au=Horovitz%2C+Silvina+G%3BFukunaga%2C+Masaki%3Bde+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BFulton%2C+Susan+C%3BBalkin%2C+Thomas+J%3BDuyn%2C+Jeff+H&rft.aulast=Horovitz&rft.aufirst=Silvina&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resting-State Functional Connectivity Measured by VASO and BOLD T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39984752; 4244370 DE: JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Yihong AU - Gu, Hong AU - Stein, Elliot A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39984752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Resting-State+Functional+Connectivity+Measured+by+VASO+and+BOLD&rft.au=Yang%2C+Yihong%3BGu%2C+Hong%3BStein%2C+Elliot+A&rft.aulast=Yang&rft.aufirst=Yihong&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decision-Making for Invasive Prenatal Testing: The Role of Ambivalence T2 - 2006 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2006) AN - 39961175; 4227547 JF - 2006 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2006) AU - Biesecker, B B AU - Marteau, T Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Decision making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2006%29&rft.atitle=Decision-Making+for+Invasive+Prenatal+Testing%3A+The+Role+of+Ambivalence&rft.au=Biesecker%2C+B+B%3BMarteau%2C+T&rft.aulast=Biesecker&rft.aufirst=B&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={99CE444B-70A1-45CB-8214-8 005F05A6519} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Experimental Comparison of Signal-To-Noise between 16 and 8 Element Receive-Only Brain Gapped Array Coils and Birdcage Head Coil at 3 Tesla T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39959254; 4245688 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bodurka, Jerzy AU - Duyn, Jeff AU - Talagala, Lalith AU - Bandettini, Peter Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Head UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39959254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Experimental+Comparison+of+Signal-To-Noise+between+16+and+8+Element+Receive-Only+Brain+Gapped+Array+Coils+and+Birdcage+Head+Coil+at+3+Tesla&rft.au=Bodurka%2C+Jerzy%3BDuyn%2C+Jeff%3BTalagala%2C+Lalith%3BBandettini%2C+Peter&rft.aulast=Bodurka&rft.aufirst=Jerzy&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toward Quantitative Whole Brain Pulsed Arterial Spin Labeling: Estimation of Transit Time with Cardiac Gating at 3T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39958017; 4244284 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Luh, Wen-Ming AU - Bodurka, Jerzy AU - Bandettini, Peter A Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Gating KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Toward+Quantitative+Whole+Brain+Pulsed+Arterial+Spin+Labeling%3A+Estimation+of+Transit+Time+with+Cardiac+Gating+at+3T&rft.au=Luh%2C+Wen-Ming%3BBodurka%2C+Jerzy%3BBandettini%2C+Peter+A&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Cortical TCA Cycle Rate during Functional Stimulation Determined at 11.7 Tesla T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39957056; 4242353 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Yang, Jehoon AU - Li, Dawen AU - Shen, Jun Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Tricarboxylic acid cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39957056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Increased+Cortical+TCA+Cycle+Rate+during+Functional+Stimulation+Determined+at+11.7+Tesla&rft.au=Yang%2C+Jehoon%3BLi%2C+Dawen%3BShen%2C+Jun&rft.aulast=Yang&rft.aufirst=Jehoon&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myocardial Blood Flow can be Quantified in Sub-Gram Regions of Interest in Clinical MR First Pass Perfusion Studies T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39952343; 4244070 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Hsu, Li-yueh AU - Mordini, Federico E AU - Mirota, Daniel AU - Funka-Lea, Gareth AU - Arai, Andrew E Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Blood circulation KW - Perfusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Myocardial+Blood+Flow+can+be+Quantified+in+Sub-Gram+Regions+of+Interest+in+Clinical+MR+First+Pass+Perfusion+Studies&rft.au=Hsu%2C+Li-yueh%3BMordini%2C+Federico+E%3BMirota%2C+Daniel%3BFunka-Lea%2C+Gareth%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-yueh&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlations between Diffusion Tensor Indices and Intravoxel Tissue Volume Fractions in Human Brain T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 39951560; 4244322 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Zhan, Wang AU - Gu, Hong AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39951560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Correlations+between+Diffusion+Tensor+Indices+and+Intravoxel+Tissue+Volume+Fractions+in+Human+Brain&rft.au=Zhan%2C+Wang%3BGu%2C+Hong%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Zhan&rft.aufirst=Wang&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Separating Means from Ends: Turning Back to the Goals of Genetic Counseling T2 - 38th European Human Genetics Conference (EHGC 2006) AN - 39949912; 4226234 JF - 38th European Human Genetics Conference (EHGC 2006) AU - Shiloh, S Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Genetic counselling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.atitle=Separating+Means+from+Ends%3A+Turning+Back+to+the+Goals+of+Genetic+Counseling&rft.au=Shiloh%2C+S&rft.aulast=Shiloh&rft.aufirst=S&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=38th+European+Human+Genetics+Conference+%28EHGC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={99CE444B -70A1-45CB-8214-8005F05A6519}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. AN - 67943699; 16678114 AB - The receptor associated protein (RAP) is an antagonist and molecular chaperone that binds tightly to low-density lipoprotein receptor family members in the endoplasmic reticulum (ER). After escorting these receptors to the Golgi, RAP dissociates from the receptors. The molecular mechanism of the dissociation has been unknown until now. The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi. Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP. This histidine switch may serve as a general mechanism for regulating cell trafficking events. JF - Molecular cell AU - Lee, Donghan AU - Walsh, Joseph D AU - Mikhailenko, Irina AU - Yu, Ping AU - Migliorini, Molly AU - Wu, Yibing AU - Krueger, Susan AU - Curtis, Joseph E AU - Harris, Bradley AU - Lockett, Stephen AU - Blacklow, Steve C AU - Strickland, Dudley K AU - Wang, Yun-Xing AD - Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2006/05/05/ PY - 2006 DA - 2006 May 05 SP - 423 EP - 430 VL - 22 IS - 3 SN - 1097-2765, 1097-2765 KW - Membrane Glycoproteins KW - 0 KW - Receptors, LDL KW - Histidine KW - 4QD397987E KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Solubility KW - Titrimetry KW - COS Cells KW - Models, Molecular KW - Hydrogen-Ion Concentration KW - Protein Processing, Post-Translational KW - Protein Binding KW - Conserved Sequence KW - Alanine -- metabolism KW - Cercopithecus aethiops KW - Mutation -- genetics KW - Protein Structure, Tertiary KW - Endoplasmic Reticulum -- metabolism KW - Membrane Glycoproteins -- chemistry KW - Genes, Switch KW - Gene Expression Regulation KW - Golgi Apparatus -- metabolism KW - Histidine -- metabolism KW - Receptors, LDL -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67943699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=RAP+uses+a+histidine+switch+to+regulate+its+interaction+with+LRP+in+the+ER+and+Golgi.&rft.au=Lee%2C+Donghan%3BWalsh%2C+Joseph+D%3BMikhailenko%2C+Irina%3BYu%2C+Ping%3BMigliorini%2C+Molly%3BWu%2C+Yibing%3BKrueger%2C+Susan%3BCurtis%2C+Joseph+E%3BHarris%2C+Bradley%3BLockett%2C+Stephen%3BBlacklow%2C+Steve+C%3BStrickland%2C+Dudley+K%3BWang%2C+Yun-Xing&rft.aulast=Lee&rft.aufirst=Donghan&rft.date=2006-05-05&rft.volume=22&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-07 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2FTU; PDB N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly AN - 17146994; 6810796 AB - Iron-sulfur clusters are prosthetic groups composed of sulfur and iron that are found in respiratory chain complexes and numerous enzymes. Iron-sulfur clusters are synthesized in a multistep process that utilizes cysteine desulfurases, scaffold proteins, chaperones, and iron donors. Assembly of iron-sulfur clusters occurs in the mitochondrial matrix of mammalian cells, but cytosolic isoforms of three major mammalian iron-sulfur cluster (ISC) assembly components have been found, raising the possibility that de novo ironsulfur cluster biogenesis also occurs in cytosol. The human cysteine desulfurase, ISCS, has two isoforms, one of which targets to the mitochondria, whereas the other less abundant form is cytosolic and nuclear. The open-reading frame of cytosolic mammalian ISCS begins at the second AUG of the transcript and lacks mitochondrial targeting information. Yeast complementation experiments have suggested that the human cytosolic ISCS isoform (c-ISCS) cannot be functional. To evaluate function of c-ISCS, we overexpressed the human cytosolic ISCS in yeast Pichia pastoris and showed that the cytosolic form of ISCS is an active cysteine desulfurase that covalently binds super(35)S acquired from desulfuration of radiolabeled cysteine. Human cytosolic ISCS dimerized as efficiently as bacterial ISCS and formed a complex in vitro with overexpressed cytosolic human ISCU. When incubated with iron regulatory protein 1, cysteine, and iron, the cytosolic forms of ISCS and ISCU facilitated efficient formation of a [4Fe-4S] cluster on IRP1. Thus, the cytosolic form of ISCS is a functional cysteine desulfurase that can collaborate with cytosolic ISCU to promote de novo iron-sulfur cluster formation. JF - Journal of Biological Chemistry AU - Li, Kuanyu AU - Tong, Wing-Hang AU - Hughes, Robert M AU - Rouault, Tracey A AD - NICHD, National Institutes of Health, Intramural Program, Bethesda, Maryland 20892 Y1 - 2006/05/05/ PY - 2006 DA - 2006 May 05 SP - 12344 EP - 12351 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 18 SN - 0021-9258, 0021-9258 KW - Iron-sulfur clusters KW - cysteine desulfurase KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Sulfur KW - Transcription KW - Mitochondria KW - Enzymes KW - Iron regulatory protein KW - scaffolds KW - Protein structure KW - Prosthetic groups KW - Mammalian cells KW - Cysteine KW - Cytosol KW - Chaperones KW - Pichia pastoris KW - Electron transport KW - Iron KW - Protein interaction KW - G 07431:Enzymes KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17146994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Roles+of+the+Mammalian+Cytosolic+Cysteine+Desulfurase%2C+ISCS%2C+and+Scaffold+Protein%2C+ISCU%2C+in+Iron-Sulfur+Cluster+Assembly&rft.au=Li%2C+Kuanyu%3BTong%2C+Wing-Hang%3BHughes%2C+Robert+M%3BRouault%2C+Tracey+A&rft.aulast=Li&rft.aufirst=Kuanyu&rft.date=2006-05-05&rft.volume=281&rft.issue=18&rft.spage=12344&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sulfur; Enzymes; Mitochondria; Transcription; Iron regulatory protein; scaffolds; Protein structure; Prosthetic groups; Mammalian cells; Cysteine; Cytosol; Chaperones; Electron transport; Iron; Protein interaction; Pichia pastoris ER - TY - CPAPER T1 - Human Lymphocytes Genetically Engineered to Express Anti-Tumor T Cell Receptors Persist Long-Term In Vivo and can Mediate Cancer Regression T2 - 12th Annual Meeting of the International Society for Cellular Therapy (ISCT 2006) AN - 40197449; 4334585 JF - 12th Annual Meeting of the International Society for Cellular Therapy (ISCT 2006) AU - Morgan, R Y1 - 2006/05/04/ PY - 2006 DA - 2006 May 04 KW - Cancer KW - Lymphocytes KW - T-cell receptor KW - Genetic engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40197449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2006%29&rft.atitle=Human+Lymphocytes+Genetically+Engineered+to+Express+Anti-Tumor+T+Cell+Receptors+Persist+Long-Term+In+Vivo+and+can+Mediate+Cancer+Regression&rft.au=Morgan%2C+R&rft.aulast=Morgan&rft.aufirst=R&rft.date=2006-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B542F81AD%2D4B67%2D44C8% 2DB20A%2D2967C8DF7DDF%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A loss-of-function RNA interference screen for molecular targets in cancer AN - 19962367; 6799367 AB - The pursuit of novel therapeutic agents in cancer relies on the identification and validation of molecular targets. Hallmarks of cancer include self-sufficiency in growth signals and evasion from apoptosis; genes that regulate these processes may be optimal for therapeutic attack. Here we describe a loss-of-function screen for genes required for the proliferation and survival of cancer cells using an RNA interference library. We used a doxycycline- inducible retroviral vector for the expression of small hairpin RNAs (shRNAs) to construct a library targeting 2,500 human genes. We used retroviral pools from this library to infect cell lines representing two distinct molecular subgroups of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like DLBCL and germinal centre B-cell-like DLBCL. Each vector was engineered to contain a unique 60-base-pair 'bar code', allowing the abundance of an individual shRNA vector within a population of transduced cells to be measured using microarrays of the bar-code sequences. We observed that a subset of shRNA vectors was depleted from the transduced cells after three weeks in culture only if shRNA expression was induced. In activated B-cell-like DLBCL cells, but not germinal centre B-cell-like DLBCL cells, shRNAs targeting the NF-kappaB pathway were depleted, in keeping with the essential role of this pathway in the survival of activated B-cell-like DLBCL. This screen uncovered CARD11 as a key upstream signalling component responsible for the constitutive IkappaB kinase activity in activated B-cell-like DLBCL. The methodology that we describe can be used to establish a functional taxonomy of cancer and help reveal new classes of therapeutic targets distinct from known oncogenes. JF - Nature AU - Ngo, Vu N AU - Davis, REric AU - Lamy, Laurence AU - Yu, Xin AU - Zhao, Hong AU - Lenz, Georg AU - Lam, Lloyd T AU - Dave, Sandeep AU - Yang, Liming AU - Powell, John AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute and Bioinformatics and Molecular Analysis Section, Computational Bioscience and Engineering Laboratory, CIT, National Institutes of Health, Bethesda, Maryland 20892, USA, lstaudt@mail.nih.gov Y1 - 2006/05/04/ PY - 2006 DA - 2006 May 04 SP - 106 EP - 110 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 441 IS - 7089 SN - 0028-0836, 0028-0836 KW - CARD11 protein KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts KW - Cell survival KW - double prime B-cell lymphoma KW - Apoptosis KW - Lymphocytes B KW - Cell culture KW - IKK protein KW - Cancer KW - NF- Kappa B protein KW - Expression vectors KW - Oncogenes KW - Gene libraries KW - RNA-mediated interference KW - Taxonomy KW - Germinal centers KW - Cell proliferation KW - Transduction KW - Signal transduction KW - W 30965:Miscellaneous, Reviews KW - V 22310:Genetics, Taxonomy & Structure KW - N 14060:Expression of inserted DNA KW - W3 33130:Genetic based (PCR, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=A+loss-of-function+RNA+interference+screen+for+molecular+targets+in+cancer&rft.au=Ngo%2C+Vu+N%3BDavis%2C+REric%3BLamy%2C+Laurence%3BYu%2C+Xin%3BZhao%2C+Hong%3BLenz%2C+Georg%3BLam%2C+Lloyd+T%3BDave%2C+Sandeep%3BYang%2C+Liming%3BPowell%2C+John%3BStaudt%2C+Louis+M&rft.aulast=Ngo&rft.aufirst=Vu&rft.date=2006-05-04&rft.volume=441&rft.issue=7089&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04687 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; double prime B-cell lymphoma; Lymphocytes B; Cell culture; IKK protein; Cancer; NF- Kappa B protein; Expression vectors; Oncogenes; Gene libraries; RNA-mediated interference; Taxonomy; Cell proliferation; Germinal centers; Transduction; Signal transduction DO - http://dx.doi.org/10.1038/nature04687 ER - TY - JOUR T1 - Validation of a Model of Lung Cancer Risk Prediction Among Smokers AN - 17147742; 6812109 AB - The Bach model was developed to predict the absolute 10-year risk of developing lung cancer among smokers by use of participants in the Carotene and Retinol Efficacy Trial of lung cancer prevention. We assessed the validity of the Bach model among 6239 smokers from the placebo arm of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. The expected numbers of lung cancer cases and deaths without lung cancer were calculated from the Bach model and compared with the observed numbers of corresponding events over 10 years. We found that the risk model slightly underestimated the observed lung cancer risk (number of lung cancers expected/number observed = 0.89, 95% confidence interval [CI] = 0.80 to 0.99) over 10 years. The competing risk portion of the model substantially underestimated risk of non-lung cancer mortality (number of non-lung cancer deaths expected/number observed = 0.61, 95% CI = 0.57 to 0.64) over 10 years. The age-specific concordance indices for 10-year predictions were 0.77 (95% CI = 0.70 to 0.84), 0.59 (95% CI = 0.53 to 0.65), 0.62 (95% CI = 0.57 to 0.67), and 0.57 (95% CI = 0.49 to 0.67) for the age groups 50-54, 55-59, 60-64, and 65-69 years, respectively. Periodic radiographic screening in the ATBC Study may explain why slightly more cancers were observed than expected from the Bach model. JF - Journal of the National Cancer Institute AU - Cronin, Kathleen A AU - Gail, Mitchell H AU - Zou, Zhaohui AU - Bach, Peter B AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Control and Population Sciences (KAC), Division of Cancer Epidemiology and Genetics (MHG, DA), National Cancer Institute, Bethesda, MD Y1 - 2006/05/03/ PY - 2006 DA - 2006 May 03 SP - 637 EP - 640 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 9 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Prediction KW - Mortality KW - Smoking KW - Mathematical models KW - prevention KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Validation+of+a+Model+of+Lung+Cancer+Risk+Prediction+Among+Smokers&rft.au=Cronin%2C+Kathleen+A%3BGail%2C+Mitchell+H%3BZou%2C+Zhaohui%3BBach%2C+Peter+B%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Cronin&rft.aufirst=Kathleen&rft.date=2006-05-03&rft.volume=98&rft.issue=9&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Prediction; Smoking; Mortality; Mathematical models; prevention; Lung cancer ER - TY - CPAPER T1 - Public Perceptions on Road Safety - Does it Influence Policy Making Process T2 - 8th World Conference on Injury Prevention and Safety Promotion AN - 40066224; 4250835 JF - 8th World Conference on Injury Prevention and Safety Promotion AU - Gopalkrishna, G Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 KW - Traffic safety KW - Perception KW - Policies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.atitle=Public+Perceptions+on+Road+Safety+-+Does+it+Influence+Policy+Making+Process&rft.au=Gopalkrishna%2C+G&rft.aulast=Gopalkrishna&rft.aufirst=G&rft.date=2006-05-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.issn=&rft_id=info:doi/ L2 - http://www.safety2006.info/programme.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sensitization and the Chronic Pain Matrix: A Mechanism Based Approach T2 - 14th Annual Scientific Meeting of the Australasian Faculty of Rehabilitation Medicine AN - 40041058; 4208561 JF - 14th Annual Scientific Meeting of the Australasian Faculty of Rehabilitation Medicine AU - Shah, Jay Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 KW - Pain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40041058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Scientific+Meeting+of+the+Australasian+Faculty+of+Rehabilitation+Medicine&rft.atitle=Sensitization+and+the+Chronic+Pain+Matrix%3A+A+Mechanism+Based+Approach&rft.au=Shah%2C+Jay&rft.aulast=Shah&rft.aufirst=Jay&rft.date=2006-05-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Scientific+Meeting+of+the+Australasian+Faculty+of+Rehabilitation+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.afrm2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety and Health Issues as Affected by Organizational Factors in Electronics and Garment Industries T2 - 8th World Conference on Injury Prevention and Safety Promotion AN - 40012885; 4250625 JF - 8th World Conference on Injury Prevention and Safety Promotion AU - Lu, J. Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 KW - Health and safety KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.atitle=Safety+and+Health+Issues+as+Affected+by+Organizational+Factors+in+Electronics+and+Garment+Industries&rft.au=Lu%2C+J.&rft.aulast=Lu&rft.aufirst=J.&rft.date=2006-05-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+World+Conference+on+Injury+Prevention+and+Safety+Promotion&rft.issn=&rft_id=info:doi/ L2 - http://www.safety2006.info/programme.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The ventral premotor cortex, corticospinal region C, and the origin of primates. AN - 85394786; pmid-16881263 AB - In addition to its projection to the brainstem, the ventral premotor cortex (PMv) sends axons directly to the upper cervical spinal cord in primates, with few terminations more caudally in either the cervical enlargement or in the lumbosacral spinal segments. This finding suggests that PMv plays a role in the control of head movements. Furthermore, comparative neuroanatomical studies indicate that PMv's corticospinal projection was a primate innovation. If the first primates adapted to an arboreal life that involved unimanual feeding, as some experts believe, then perhaps PMv's corticospinal projection evolved to coordinate head movements with this kind of feeding behavior. The computations underlying such control could later be adapted to control head orientation during social signaling. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Wise, Steven P AD - Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892-4401, USA. stevenwise@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 521 EP - 524 VL - 42 IS - 4 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Biological Evolution KW - Head Movements KW - Humans KW - Motor Cortex: anatomy & histology KW - *Motor Cortex: physiology KW - Nerve Net: anatomy & histology KW - Nerve Net: physiology KW - Primates: anatomy & histology KW - *Primates: physiology KW - Psychomotor Performance: physiology KW - Pyramidal Tracts: anatomy & histology KW - *Pyramidal Tracts: physiology KW - Social Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=The+ventral+premotor+cortex%2C+corticospinal+region+C%2C+and+the+origin+of+primates.&rft.au=Wise%2C+Steven+P&rft.aulast=Wise&rft.aufirst=Steven&rft.date=2006-05-01&rft.volume=42&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies AN - 815539965; 13860213 AB - The transmissible spongiform encephalopathies (TSE), or prion diseases, are a group of rare, fatal, and transmissible neurodegenerative diseases of mammals for which there are no known viral or bacterial etiological agents. The bovine form of these diseases, bovine spongiform encephalopathy (BSE), has crossed over into humans to cause variant Creutzfeldt-Jakob disease. As a result, BSE and the TSE diseases are now considered a significant threat to human health. Understanding the basic mechanisms of TSE pathogenesis is essential for the development of effective TSE diagnostic tests and anti-TSE therapeutic regimens. This review provides an overview of the molecular mechanisms that underlie this enigmatic group of diseases. JF - Molecular Biotechnology AU - Priola, Suzette A AU - Vorberg, Ina AD - Laboratory of Persistent Viral Diseases National Institute of, Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 S. 4th St., 59840, Hamilton, MT, spriola@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 71 EP - 88 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 33 IS - 1 SN - 1073-6085, 1073-6085 KW - Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Transmissible spongiform encephalopathy KW - Neurodegenerative diseases KW - Molecular modelling KW - Creutzfeldt-Jakob disease KW - Bovine spongiform encephalopathy KW - Reviews KW - Prion protein KW - N3 11007:Neurobiology KW - W 30900:Methods KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815539965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Molecular+aspects+of+disease+pathogenesis+in+the+transmissible+spongiform+encephalopathies&rft.au=Priola%2C+Suzette+A%3BVorberg%2C+Ina&rft.aulast=Priola&rft.aufirst=Suzette&rft.date=2006-05-01&rft.volume=33&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1385%2FMB%3A33%3A1%3A71 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Molecular modelling; Neurodegenerative diseases; Bovine spongiform encephalopathy; Creutzfeldt-Jakob disease; Reviews; Prion protein DO - http://dx.doi.org/10.1385/MB:33:1:71 ER - TY - JOUR T1 - Lamotrigine adjunctive therapy in children with refractory epilepsy: a medical center study. AN - 69025120; 17078464 AB - The aim of this study was to investigate the effects of adjunctive lamotrigine (LTG) in refractory epilepsy in Taiwan, especially including patients who had undergone ineffective epileptic surgeries. Totally, 27 recruited children and adolescents with refractory epilepsy were treated with LTG add-on therapy, but 23 were enrolled statistically during 2 years period trial. Ten of the 23 patients (43.5%), including 5 undergoing epileptic surgeries, before had a > 50% reduction in seizure frequency. Surprisingly, LTG was found to have excellent response in six patients with Lennox-Gastaut Syndrome (LGS), 5 of whom had received anterior 2/3 callosotomy prior to the trial. Non-seizure related positive effects were presented in 3 patients, including greater alertness and attentiveness in 2 patients and improvement in mood in one patient. This open trial found that LTG was an effective add-on anti-epileptic drug (AED) in Taiwanese children and adolescents with refractory epilepsy and in cases with LGS even after ineffective callosotomy. JF - Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi AU - Chen, Shyi-Jou AU - Chang, Kai-Ping AU - Wong, Tai-Tong AU - Kwan, Shang-Yeong AU - Hsu, Mu-Ling AU - Wang, Chih-Chien AD - Department of Pediatrics, Tri-Service General Hospital, No. 325, Section 2, Cheng-Kung Road, Nei-Hu 114, Taipei, Taiwan. md900012@ndmctsgh.edu.tw PY - 2006 SP - 123 EP - 126 VL - 47 IS - 3 SN - 1608-8115, 1608-8115 KW - Anticonvulsants KW - 0 KW - Triazines KW - lamotrigine KW - U3H27498KS KW - Index Medicus KW - Humans KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Epilepsy -- surgery KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Triazines -- adverse effects KW - Triazines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+paediatrica+Taiwanica+%3D+Taiwan+er+ke+yi+xue+hui+za+zhi&rft.atitle=Lamotrigine+adjunctive+therapy+in+children+with+refractory+epilepsy%3A+a+medical+center+study.&rft.au=Chen%2C+Shyi-Jou%3BChang%2C+Kai-Ping%3BWong%2C+Tai-Tong%3BKwan%2C+Shang-Yeong%3BHsu%2C+Mu-Ling%3BWang%2C+Chih-Chien&rft.aulast=Chen&rft.aufirst=Shyi-Jou&rft.date=2006-05-01&rft.volume=47&rft.issue=3&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Acta+paediatrica+Taiwanica+%3D+Taiwan+er+ke+yi+xue+hui+za+zhi&rft.issn=16088115&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-12 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol abrogates angiotensin II-stimulated vascular smooth muscle cell growth. AN - 68695810; 16641869 AB - Aberrant vascular smooth muscle cell (VSMC) proliferation is one of the etiological factors for hypertension and stroke. Angiotensin II (Ang II) and ethanol (EtOH) have been shown to modulate the proliferation of vascular smooth muscle cells (VSMCs) individually, but the combined effects of Ang II and EtOH on VSMC proliferative activities are unknown. The objective of this study was to determine the effects of EtOH, Ang II, and the combination of Ang II and EtOH on DNA synthesis, cell number, cyclic AMP (cAMP) production, and Mitogen-Activated Protein Kinase (MAPK) or (p44/42) activities in murine primary VSMCs. Cell growth was determined by [3H] thymidine incorporation and confirmed by cell counts using a hemacytometer. Cyclic AMP assays were carried out using commercially available kits. MAPK activity was determined by immunoprecipitation studies using an ELK-1 fusion protein as a substrate. Ang II (10 microM) stimulated DNA synthesis by four-fold (P < 0.05), cAMP production by 50% (P < 0.05), and MAPK (p44/42) activities by more than seven-fold (P < 0.01). In contrast, EtOH (100 mM) had no significant effects on DNA synthesis, cell number, and cAMP production. Ethanol exacerbated cAMP production by several fold but inhibited MAPK activity and subsequent cell growth induced by Ang II. These results suggest that EtOH elicits a regulatory effect on the Ang II signaling pathway. JF - Medical science monitor : international medical journal of experimental and clinical research AU - Cain, Monique L AU - Hester, Robert L AU - Izevbigie, Ernest B AD - Molecular Genetics and Molecular and Cellular Signaling Laboratory, Department of Biology, and National Institutes of Health Center for Environmental Health, Jackson State University, Jackson, MS 39217, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - BR162 EP - BR168 VL - 12 IS - 5 SN - 1234-1010, 1234-1010 KW - Angiotensin II KW - 11128-99-7 KW - Ethanol KW - 3K9958V90M KW - DNA KW - 9007-49-2 KW - Cyclic AMP KW - E0399OZS9N KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Index Medicus KW - Rats KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Cell Proliferation -- drug effects KW - MAP Kinase Signaling System -- drug effects KW - Cyclic AMP -- biosynthesis KW - Animals KW - Drug Interactions KW - Cells, Cultured KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Enzyme Activation -- drug effects KW - DNA -- biosynthesis KW - Ethanol -- pharmacology KW - Muscle, Smooth, Vascular -- drug effects KW - Ethanol -- administration & dosage KW - Muscle, Smooth, Vascular -- cytology KW - Angiotensin II -- administration & dosage KW - Muscle, Smooth, Vascular -- metabolism KW - Angiotensin II -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68695810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+science+monitor+%3A+international+medical+journal+of+experimental+and+clinical+research&rft.atitle=Ethanol+abrogates+angiotensin+II-stimulated+vascular+smooth+muscle+cell+growth.&rft.au=Cain%2C+Monique+L%3BHester%2C+Robert+L%3BIzevbigie%2C+Ernest+B&rft.aulast=Cain&rft.aufirst=Monique&rft.date=2006-05-01&rft.volume=12&rft.issue=5&rft.spage=BR162&rft.isbn=&rft.btitle=&rft.title=Medical+science+monitor+%3A+international+medical+journal+of+experimental+and+clinical+research&rft.issn=12341010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topoisomerase I, II alpha and II beta mRNA expression in peripheral blood mononuclear cells of patients with solid tumor: preliminary results. AN - 68591638; 16807458 AB - The pyrimidine antimetabolite Gemcitabine (G) (2',2'-difluorodeoxycytidine) is used against several malignancies G exerts its antitumour effect mainly by incorporation of its triphosphate metabolite (dFdCTP) into DNA. Subsequently, DNA polymerase adds one additional deoxynucleotide and DNA synthesis is interrupted. The nuclear enzymes topoisomerase I and II (TPs) are critical for DNA function and cell survival; they control, maintain and modify DNA topology during both replication and translation of genetic materials. These enzymes induce cuts in one or both strands of DNA, allowing strands to pass through the nick and then rejoining the nicked strand of DNA. Anti-topoisomerase (TPs-inhibitors) drugs exist and are largely used in chemotherapy, however, most often blindly of the cancer TPs status. To understand the best association between G and TPs-inhibitors, we studied: (a) Topoisomerases I, II alpha and II beta mRNA expression in Peripheral Mononuclear Blood Cells (PBMCs) of patients with solid tumor, after 1, 2, 3, 4, 5, 6 h after treatment with Gemcitabine (G); b) in vivo expression of TPs genes after administration of Gemcitabine (a topoisomerases up-regulating drug) combined with the TPs inhibitors drugs (TID) Topotecan (T) and Etoposide (E), added to the culture beneath 1 h after TPD treatment. TPs mRNA expression was measured by quantitative real-time RT-PCR in PBMCs. The administration of 1-h infused G is followed by a fast rise of TPs expression (P > 0.0001 Student's t test, paired data, each patient control of himself); TPs inhibitors, sequentially given after G, highly reduced the TPs rising (P > 0.0001). G induces a TPs increase. A rationale might be available for combination chemotherapy (G plus TPs inhibitors). The study is ongoing to enroll further patients. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Cartei, G AU - Trestin, A AU - Colombrino, E AU - Nadai, M AU - Richter, S N AU - Barzon, L AU - Palù, G AU - Palumbo, M AU - Padua Pharmacology Oncology Group (PPOG) AD - UOC Medical Oncology, 1 Floor, National Cancer Institute IOV-IRCSS, University of Padova, Padova, Italy. ; Padua Pharmacology Oncology Group (PPOG) Y1 - 2006/05// PY - 2006 DA - May 2006 SP - v25 EP - v28 VL - 17 Suppl 5 KW - Antigens, Neoplasm KW - 0 KW - Antimetabolites, Antineoplastic KW - DNA-Binding Proteins KW - Enzyme Inhibitors KW - RNA, Messenger KW - Topoisomerase I Inhibitors KW - Topoisomerase II Inhibitors KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - DNA topoisomerase II alpha KW - DNA topoisomerase II beta KW - Index Medicus KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Drug Administration Schedule KW - Enzyme Inhibitors -- administration & dosage KW - Humans KW - Aged KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Antimetabolites, Antineoplastic -- pharmacology KW - RNA, Messenger -- metabolism KW - Aged, 80 and over KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Adult KW - Leukocytes, Mononuclear -- metabolism KW - Middle Aged KW - Time Factors KW - Neoplasms -- drug therapy KW - DNA Topoisomerases, Type II -- genetics KW - Deoxycytidine -- analogs & derivatives KW - DNA Topoisomerases, Type II -- metabolism KW - DNA-Binding Proteins -- genetics KW - DNA Topoisomerases, Type I -- genetics KW - Neoplasms -- genetics KW - Antigens, Neoplasm -- metabolism KW - Deoxycytidine -- administration & dosage KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Antigens, Neoplasm -- genetics KW - Deoxycytidine -- pharmacology KW - DNA Topoisomerases, Type I -- metabolism KW - Neoplasms -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68591638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Topoisomerase+I%2C+II+alpha+and+II+beta+mRNA+expression+in+peripheral+blood+mononuclear+cells+of+patients+with+solid+tumor%3A+preliminary+results.&rft.au=Cartei%2C+G%3BTrestin%2C+A%3BColombrino%2C+E%3BNadai%2C+M%3BRichter%2C+S+N%3BBarzon%2C+L%3BPal%C3%B9%2C+G%3BPalumbo%2C+M%3BPadua+Pharmacology+Oncology+Group+%28PPOG%29&rft.aulast=Cartei&rft.aufirst=G&rft.date=2006-05-01&rft.volume=17+Suppl+5&rft.issue=&rft.spage=v25&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-29 N1 - Date created - 2006-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction and measurement of cytotoxic T lymphocyte activity. AN - 68398812; 18432971 AB - Cytotoxic T lymphocytes (CTL) kill target cells on the basis of cell-surface antigen recognition and are important in the host response to tumors, transplants, and viruses. This unit presents several protocols for generating and measuring CTL activity. The first describes generating CTL against some of the most commonly used target antigens. Two methods for the quantitation of CTL activity are described based on the two pathways used bt CTL to kill target cells. In one pathway, they release lytic granules containing perforin and granzymes, leading to apoptosis and target cell lysis. In a second pathway, they trigger apoptosis via Fas/Fas ligand interactions. In the chromium-release assay provided here, labeled antigenic targets are recognized and lysed, releasing radioactivity into the supernatant. In the JAM test protocol, CTL activity is determined by measuring degradation of radioactively labeled DNA in target cells that have undergone apoptotic cell death. Rather than measuring release of radioactivity, the JAM test measures the amount of DNA retained in target cells that are not killed by CTL. Two support protocols detail the generation of CTL precursors (CTLp) against antigens that require priming in vivo. A second set of support protocols describe the preparation of both stimulator and target cells for these responses using two representative antigens, trinitrophenyl and viruses. Finally, two alternate protocols illustrate how to determine total CTLp activity in a population that might express cytolytic activity. These protocols bypass MHC restriction and the original antigen specificity of CTLp by polyclonal stimulation of CTLp with mitogens followed by attachment of CTL to target cells and subsequent cytolysis. JF - Current protocols in immunology AU - Wonderlich, John AU - Shearer, Gene AU - Livingstone, Alexandra AU - Brooks, Andrew AD - National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 VL - Chapter 3 KW - Granzymes KW - EC 3.4.21.- KW - Index Medicus KW - Cytotoxicity, Immunologic KW - Animals KW - Apoptosis KW - Cytoplasmic Granules -- immunology KW - Mice KW - DNA Fragmentation KW - Cytoplasmic Granules -- metabolism KW - Granzymes -- metabolism KW - Cytotoxicity Tests, Immunologic -- methods KW - T-Lymphocytes, Cytotoxic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68398812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+immunology&rft.atitle=Induction+and+measurement+of+cytotoxic+T+lymphocyte+activity.&rft.au=Wonderlich%2C+John%3BShearer%2C+Gene%3BLivingstone%2C+Alexandra%3BBrooks%2C+Andrew&rft.aulast=Wonderlich&rft.aufirst=John&rft.date=2006-05-01&rft.volume=Chapter+3&rft.issue=&rft.spage=Unit+3.11&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+immunology&rft.issn=1934-368X&rft_id=info:doi/10.1002%2F0471142735.im0311s72 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/0471142735.im0311s72 ER - TY - JOUR T1 - Biosensors for the analysis of food- and waterborne pathogens and their toxins. AN - 68109653; 16792089 AB - Biosensors are devices which combine a biochemical recognition element with a physical transducer. There are various types of biosensors, including electrochemical, acoustical, and optical sensors. Biosensors are used for medical applications and for environmental testing. Although biosensors are not commonly used for food microbial analysis, they have great potential for the detection of microbial pathogens and their toxins in food. They enable fast or real-time detection, portability, and multipathogen detection for both field and laboratory analysis. Several applications have been developed for microbial analysis of food pathogens, including E. coli O157:H7, Staphylococcus aureus, Salmonella, and Listeria monocytogenes, as well as various microbial toxins such as staphylococcal enterotoxins and mycotoxins. Biosensors have several potential advantages over other methods of analysis, including sensitivity in the range of ng/mL for microbial toxins and <100 colony-forming units/mL for bacteria. Fast or real-time detection can provide almost immediate interactive information about the sample tested, enabling users to take corrective measures before consumption or further contamination can occur. Miniaturization of biosensors enables biosensor integration into various food production equipment and machinery. Potential uses of biosensors for food microbiology include online process microbial monitoring to provide real-time information in food production and analysis of microbial pathogens and their toxins in finished food. Biosensors can also be integrated into Hazard Analysis and Critical Control Point programs, enabling critical microbial analysis of the entire food manufacturing process. In this review, the main biosensor approaches, technologies, instrumentation, and applications for food microbial analysis are described. JF - Journal of AOAC International AU - Rasooly, Avraham AU - Herold, Keith E AD - National Institutes of Health, National Cancer Institute, Cancer Diagnosis Program, 6130 Executive Blvd, Rockville, MD 20852, USA. rasoolya@mail.nih.gov PY - 2006 SP - 873 EP - 883 VL - 89 IS - 3 SN - 1060-3271, 1060-3271 KW - Ligands KW - 0 KW - Virulence Factors KW - Index Medicus KW - Electrochemistry -- methods KW - Food Microbiology KW - Food KW - Surface Plasmon Resonance KW - Food Contamination KW - Models, Chemical KW - Potentiometry KW - Food Analysis -- methods KW - Chemistry Techniques, Analytical -- methods KW - Biosensing Techniques -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Biosensors+for+the+analysis+of+food-+and+waterborne+pathogens+and+their+toxins.&rft.au=Rasooly%2C+Avraham%3BHerold%2C+Keith+E&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2006-05-01&rft.volume=89&rft.issue=3&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration. AN - 68069479; 16770258 AB - The safety and pharmacokinetics of a triamcinolone acetonide (TA) preservative-free (TA-PF) formulation were investigated after intravitreal administration in rabbits. A TA-PF formulation was prepared as a sterile 40-mg/mL or 160-mg/mL suspension in single-use vials by adding TA powder to 0.5% hydroxypropyl methylcellulose in normal saline. TA-PF (4-mg and 16-mg doses) and Kenalog (Bristol-Myers-Squibb, Princeton, NJ) (4-mg dose) were injected into the vitreous of separate groups of rabbits, and drug levels were measured in the vitreous over time with HPLC. Ocular toxicology (clinical examination, serial electroretinography, and histopathologic analysis) was evaluated in a separate group of animals after intravitreal TA-PF injection. The half-lives of the injection amount in the vitreous, 4-mg TA-PF, 16-mg TA-PF, and 4-mg Kenalog, were found to be 24 days, 39 days, and 23 days, respectively. There were no signs of toxicities by clinical examination after TA-PF injection. Serial electroretinograms of rabbits receiving either 4-mg or 16-mg intravitreal TA-PF injections remained normal over time. Histopathologic analysis showed normal ocular tissues in animals receiving either 4-mg or 16-mg intravitreal TA-PF injections. The half-life of TA in the vitreous after a 4-mg injection of either TA-PF or Kenalog was comparable. A 16-mg dose of TA-PF produced a long vitreous half-life, and this may be of clinical benefit in patients requiring 6 months of drug exposure in the eye for a chronic disease. JF - Retina (Philadelphia, Pa.) AU - Kim, Hyuncheol AU - Csaky, Karl G AU - Gravlin, Luisa AU - Yuan, Peng AU - Lutz, Robert J AU - Bungay, Peter M AU - Tansey, Ginger AU - DE Monasterio, Francisco AU - Potti, Gopal K AU - Grimes, George AU - Robinson, Michael R AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. PY - 2006 SP - 523 EP - 530 VL - 26 IS - 5 SN - 0275-004X, 0275-004X KW - Glucocorticoids KW - 0 KW - Ophthalmic Solutions KW - Preservatives, Pharmaceutical KW - Triamcinolone Acetonide KW - F446C597KA KW - Index Medicus KW - Animals KW - Chemistry, Pharmaceutical KW - Retina -- drug effects KW - Rabbits KW - Biological Availability KW - Vitreous Body KW - Ophthalmic Solutions -- pharmacokinetics KW - Half-Life KW - Retina -- pathology KW - Injections KW - Ophthalmic Solutions -- toxicity KW - Female KW - Male KW - Electroretinography KW - Glucocorticoids -- pharmacokinetics KW - Glucocorticoids -- toxicity KW - Triamcinolone Acetonide -- toxicity KW - Triamcinolone Acetonide -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68069479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.atitle=Safety+and+pharmacokinetics+of+a+preservative-free+triamcinolone+acetonide+formulation+for+intravitreal+administration.&rft.au=Kim%2C+Hyuncheol%3BCsaky%2C+Karl+G%3BGravlin%2C+Luisa%3BYuan%2C+Peng%3BLutz%2C+Robert+J%3BBungay%2C+Peter+M%3BTansey%2C+Ginger%3BDE+Monasterio%2C+Francisco%3BPotti%2C+Gopal+K%3BGrimes%2C+George%3BRobinson%2C+Michael+R&rft.aulast=Kim&rft.aufirst=Hyuncheol&rft.date=2006-05-01&rft.volume=26&rft.issue=5&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Retina+%28Philadelphia%2C+Pa.%29&rft.issn=0275004X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-11 N1 - Date created - 2006-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Real-time measurement of particulate matter deposition in the lung. AN - 68051164; 16760131 AB - Air pollution and cigarette smoke are recognized health risks. A method was developed for the measurement of the deposition fraction (DF) of polydisperse particulate matter (PM) in human airways. Ten normal volunteers [three females, age range 18-67 years, mean age (SD) 43.9 (14)] made single breath exhalations after inhalation to total lung capacity. The exhaled breath was diverted to a multichannel laser diffraction chamber where the particulate profiler measured 0.3 - 1.0-microm particles. DF was inversely related to expiration flow-rate, 0.69 (0.02) at 4 l min-1 and 0.5 (0.01) at 13 l min-1, respectively (p0.05). Higher breath holding times were associated with elevated DF [0.74 (0.02) at 20 s, and 0.62 (0.05) without breath holding (p<0.01)]. When the expiratory flow was controlled and the breath hold time standardized, DF was reproducible (CV = 4.85%). PM can be measured in the exhaled breath and its DF can be quantified using a portable device. These methods may be useful in studies investigating the health effects of air pollution and tobacco smoke. JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals AU - Invernizzi, G AU - Boffi, R AU - Ruprecht, A A AU - Barnes, P J AU - Kharitonov, S A AU - Paredi, P AD - Tobacco Control Unit, National Cancer Institute and SIMG-Italian College GPs, Milan, Italy. PY - 2006 SP - 221 EP - 232 VL - 11 IS - 3 SN - 1354-750X, 1354-750X KW - Air Pollutants KW - 0 KW - Tobacco Smoke Pollution KW - Index Medicus KW - Inhalation KW - Air Pollutants -- pharmacokinetics KW - Methods KW - Humans KW - Exhalation KW - Adult KW - Adsorption KW - Aged KW - Middle Aged KW - Adolescent KW - Research Design KW - Female KW - Tobacco Smoke Pollution -- analysis KW - Smoking -- adverse effects KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68051164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+%3A+biochemical+indicators+of+exposure%2C+response%2C+and+susceptibility+to+chemicals&rft.atitle=Real-time+measurement+of+particulate+matter+deposition+in+the+lung.&rft.au=Invernizzi%2C+G%3BBoffi%2C+R%3BRuprecht%2C+A+A%3BBarnes%2C+P+J%3BKharitonov%2C+S+A%3BParedi%2C+P&rft.aulast=Invernizzi&rft.aufirst=G&rft.date=2006-05-01&rft.volume=11&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Biomarkers+%3A+biochemical+indicators+of+exposure%2C+response%2C+and+susceptibility+to+chemicals&rft.issn=1354750X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-21 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reflecting on 30 years of research. A look at how NIDA has advanced the research, prevention, and treatment of drug abuse and addiction. AN - 68028638; 16736912 JF - Behavioral healthcare AU - Condon, Timothy P AD - National Institute on Drug Abuse, USA. condon0506@behavioral.net Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 14 EP - 14, 16 VL - 26 IS - 5 SN - 1931-7093, 1931-7093 KW - Health administration KW - United States KW - Humans KW - Brain Chemistry KW - Reinforcement (Psychology) KW - Forecasting KW - Signal Transduction KW - Health Priorities KW - Research Support as Topic KW - Substance-Related Disorders -- therapy KW - Behavior, Addictive -- therapy KW - Biomedical Research -- trends KW - National Institutes of Health (U.S.) KW - Behavior, Addictive -- complications KW - Substance-Related Disorders -- complications KW - Behavioral Research -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68028638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+healthcare&rft.atitle=Reflecting+on+30+years+of+research.+A+look+at+how+NIDA+has+advanced+the+research%2C+prevention%2C+and+treatment+of+drug+abuse+and+addiction.&rft.au=Condon%2C+Timothy+P&rft.aulast=Condon&rft.aufirst=Timothy&rft.date=2006-05-01&rft.volume=26&rft.issue=5&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Behavioral+healthcare&rft.issn=19317093&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High pesticide exposure events among farmers and spouses enrolled in the Agricultural Health Study. AN - 68013687; 16724787 AB - We completed a nested case-control analysis of factors associated with reporting a high pesticide exposure event (HPEE) by pesticide applicators and spouses during the five years since enrollment in the Agricultural Health Study (AHS). Cases and controls were identified from the 16,415 private pesticide applicators and 14,045 spouses with completed five-year follow-up interviews as of October 2000. Among the applicators, 306 cases with at least one HPEE in the five years since enrollment and 612 controls, randomly selected from those without a reported HPEE, were identified for analysis. Among the spouses, 63 cases were identified and 126 controls were selected. Risk for a new HPEE was increased among applicators reporting at enrollment ever having an HPEE with an odds ratio (OR) of 3.8 (95% CI: 2.7, 5.3). Compared to applicators who applied pesticides fewer than 5 days per year, the ORs ranged from 1.4 (95% CI: 0.9, 2.2) for 6 to 10 days per year to 2.2 (95% CI: 1.4, 3.6) for more than 20 application days per year. The incidence of HPEE among Iowa applicators was much greater (8.8/1000 applicators) than among North Carolina applicators (2.0/1000). Spouses reported fewer HPEEs compared to applicators (2/1000 spouses). Overall, the observed risk factors for new HPEEs among applicators are similar to risk factors observed in previous cross-sectional analyses of HPEE history. Further, only 13% of applicators and 22% of spouses with symptoms resulting from HPEE sought medical care, suggesting that pesticide poisoning surveillance data may seriously underreport the frequency of such events. JF - Journal of agricultural safety and health AU - Bell, E M AU - Sandler, D P AU - Alavanja, M C AD - Occupational and Environmental Epidemiology Branch, National Cancer Institute, USA. emb05@health.state.ny.us Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 101 EP - 116 VL - 12 IS - 2 SN - 1074-7583, 1074-7583 KW - Pesticides KW - 0 KW - Index Medicus KW - Odds Ratio KW - Humans KW - North Carolina -- epidemiology KW - Risk Factors KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - Adolescent KW - Female KW - Iowa -- epidemiology KW - Male KW - Spouses KW - Occupational Health KW - Agriculture -- methods KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Occupational Exposure -- adverse effects KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68013687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=High+pesticide+exposure+events+among+farmers+and+spouses+enrolled+in+the+Agricultural+Health+Study.&rft.au=Bell%2C+E+M%3BSandler%2C+D+P%3BAlavanja%2C+M+C&rft.aulast=Bell&rft.aufirst=E&rft.date=2006-05-01&rft.volume=12&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-02 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chaos and order in spontaneous mutation. AN - 68007844; 16723419 JF - Genetics AU - Drake, John W AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709-2233, USA. drake@niehs.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1 EP - 8 VL - 173 IS - 1 SN - 0016-6731, 0016-6731 KW - Index Medicus KW - Bacteriophages -- genetics KW - Nonlinear Dynamics KW - Mutation -- genetics KW - Eukaryotic Cells KW - Base Pairing -- genetics KW - RNA Viruses -- genetics KW - Mutagenesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68007844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Chaos+and+order+in+spontaneous+mutation.&rft.au=Drake%2C+John+W&rft.aulast=Drake&rft.aufirst=John&rft.date=2006-05-01&rft.volume=173&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-31 N1 - Date created - 2006-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1984 Jun 25;176(2):239-49 [6748077] Science. 1982 Mar 26;215(4540):1577-85 [7041255] Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5974-8 [2068073] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7160-4 [1831267] Nature. 1993 Apr 22;362(6422):709-15 [8469282] J Mol Biol. 1993 Jan 5;229(1):8-13 [8421317] J Virol. 1992 May;66(5):3093-100 [1373201] Proc Natl Acad Sci U S A. 1993 May 1;90(9):4171-5 [8387212] Science. 1993 Nov 5;262(5135):867-73 [8235608] Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8158-60 [7667262] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13072-7 [8917546] Genetics. 1998 Apr;148(4):1667-86 [9560386] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10015-9 [9707592] Environ Mol Mutagen. 1999;34(1):16-23 [10462719] Biochim Biophys Acta. 1961 Jul 22;51:165-8 [13726119] Proc Natl Acad Sci U S A. 1963 Nov;50:975-80 [14082365] Genetics. 2005 Apr;169(4):1815-24 [15695359] Genetics. 2005 Jun;170(2):969-70 [15802515] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10233-7 [16006529] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Nature. 2006 Jan 19;439(7074):344-8 [16327776] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13910-3 [10570172] J Mol Evol. 2000 Aug;51(2):173-81 [10948274] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7928-33 [11427720] Genetics. 2002 Nov;162(3):1003-18 [12454051] Genetics. 2002 Dec;162(4):1505-11 [12524327] Science. 2003 Aug 1;301(5633):643-6 [12893942] Genetics. 2004 Jul;167(3):1507-12 [15280258] Nature. 2004 Aug 5;430(7000):679-82 [15295601] Biochem Biophys Res Commun. 1965 Oct 8;21(1):6-8 [5865492] J Biol Chem. 1967 Apr 25;242(8):1970-3 [6024784] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] Nature. 1969 Mar 22;221(5186):1128-32 [4975273] Nature. 1969 Mar 22;221(5186):1132 [4378427] Cold Spring Harb Symp Quant Biol. 1968;33:339-44 [5254574] Proc Natl Acad Sci U S A. 1971 Apr;68(4):773-6 [5279518] Genetics. 1970 Jul;65(3):379-90 [4933467] Mutat Res. 1971 Oct;13(2):109-13 [5138708] Mol Gen Genet. 1972;118(1):1-10 [4662742] Mol Gen Genet. 1975 Nov 3;141(1):23-40 [765723] J Mol Biol. 1980 Nov 5;143(3):303-15 [7218357] J Virol. 1990 Aug;64(8):3960-2 [1695258] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Challenges of SNP genotyping and genetic variation: its future role in diagnosis and treatment of cancer. AN - 67985158; 16706736 AB - Thorough annotation of common germline genetic variation in the human genome has generated a foundation for the investigation of the contribution of genetics to the etiology and pathogenesis of cancer. For many malignancies, it has become increasingly apparent that numerous alleles, with small-to-moderate effects, additively contribute to cancer susceptibility. The most common genetic variant in the genome, the single nucleotide polymorphism, is of special interest for the study of susceptibility to and protection from cancer. Similarly, intense effort has focused on genetic variants that can predict either response or toxicity to therapeutic interventions. This review discusses the challenges and prospects of genetic association studies in cancer research. On the basis of recent changes in genomics and high-throughput genotyping platforms, future genetic findings of association studies could impact clinical care and public health screening. JF - Expert review of molecular diagnostics AU - Bernig, Toralf AU - Chanock, Stephen J AD - National Cancer Institute, Section on Genomic Variation, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD 20892-4605, USA. bernigt@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 319 EP - 331 VL - 6 IS - 3 KW - Index Medicus KW - Haplotypes KW - Gene Frequency KW - Models, Genetic KW - Humans KW - Genetic Predisposition to Disease KW - Pharmacogenetics KW - Genotype KW - Gene Expression Regulation, Neoplastic KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Neoplasms -- diagnosis KW - Molecular Diagnostic Techniques KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67985158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+molecular+diagnostics&rft.atitle=Challenges+of+SNP+genotyping+and+genetic+variation%3A+its+future+role+in+diagnosis+and+treatment+of+cancer.&rft.au=Bernig%2C+Toralf%3BChanock%2C+Stephen+J&rft.aulast=Bernig&rft.aufirst=Toralf&rft.date=2006-05-01&rft.volume=6&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+molecular+diagnostics&rft.issn=1744-8352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-17 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human papillomavirus testing following loop electrosurgical excision procedure identifies women at risk for posttreatment cervical intraepithelial neoplasia grade 2 or 3 disease. AN - 67975110; 16702369 AB - Loop electrosurgical excision procedure (LEEP) is the predominant treatment for cervical intraepithelial neoplasia grade 2 or 3 (CIN2+) in the United States, yet following treatment approximately 10% of women are diagnosed again with CIN2+, necessitating close follow-up of such patients. Surveillance strategies using cytology and/or human papillomavirus (HPV) testing were compared among women who underwent LEEP (n = 610) in the Atypical Squamous Cells of Undetermined Significance (ASCUS) Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study. Cervical specimens, collected at 6-month visits for 2 years, were used for cytology, Hybrid Capture 2 (HC2) detection of carcinogenic HPVs, and PCR for genotyping of carcinogenic and noncarcinogenic HPV types. At exit, women had colposcopy for safety and disease ascertainment. At the visit post-LEEP (median time: 4.5 months after LEEP), 36.9% [95% confidence interval (95% CI), 32.7-41.1%] of women were positive for carcinogenic HPV by PCR and 33.7% (95% CI, 29.7-37.9) had ASCUS or more severe (ASCUS+) cytology. The overall 2-year cumulative incidence of histologically confirmed posttreatment CIN2+ was 7.0%; this could be further stratified by the HPV risk category detected at the 6-month visit after LEEP. The 2-year risk associated with HPV16 positivity was 37.0%, significantly higher than for other carcinogenic HPV types (10.8%, P < 0.001), noncarcinogenic types (1.5%, P < 0.001), or testing HPV negative (0%). Post-LEEP cytology (using a positive threshold of ASCUS+) was 78.1% (95% CI, 60.0-90.7%) sensitive for detection of posttreatment CIN2+. By comparison, PCR for carcinogenic HPV and combination testing (using a positive result from carcinogenic HPV testing or cytology as the test threshold with HPV-negative ASCUS not referred) were significantly more sensitive (96.9% for each, P = 0.03); HC2 alone was nonsignificantly more sensitive (90.6%, P = 0.3). Specificity was similar for ASCUS+ cytology (69.1%, 95% CI, 64.6-73.3%) and PCR for carcinogenic HPV (67.1%, P = 0.5), yet was lower for HC2 (63.8%, P = 0.048) and combination testing (62.9%, P = 0.02). Women who tested positive after LEEP for carcinogenic HPV types, especially HPV16, had high risk of subsequent CIN2+. HPV-based detection methods, alone or in combination with cytology, may be useful to incorporate in post-LEEP management strategies. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Kreimer, Aimée R AU - Guido, Richard S AU - Solomon, Diane AU - Schiffman, Mark AU - Wacholder, Sholom AU - Jeronimo, José AU - Wheeler, Cosette M AU - Castle, Philip E AD - National Cancer Institute, NIH, 6130 Executive Boulevard, Bethesda, MD 20892-7333, USA. kreimera@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 908 EP - 914 VL - 15 IS - 5 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Sensitivity and Specificity KW - Genotype KW - Risk Factors KW - Humans KW - Chi-Square Distribution KW - Adult KW - Incidence KW - Predictive Value of Tests KW - Female KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- complications KW - Precancerous Conditions -- surgery KW - Papillomaviridae -- genetics KW - Papillomavirus Infections -- genetics KW - Precancerous Conditions -- epidemiology KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- epidemiology KW - Precancerous Conditions -- genetics KW - Cervical Intraepithelial Neoplasia -- genetics KW - Cervical Intraepithelial Neoplasia -- surgery KW - Cervical Intraepithelial Neoplasia -- virology KW - Papillomavirus Infections -- surgery KW - Cervical Intraepithelial Neoplasia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67975110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Human+papillomavirus+testing+following+loop+electrosurgical+excision+procedure+identifies+women+at+risk+for+posttreatment+cervical+intraepithelial+neoplasia+grade+2+or+3+disease.&rft.au=Kreimer%2C+Aim%C3%A9e+R%3BGuido%2C+Richard+S%3BSolomon%2C+Diane%3BSchiffman%2C+Mark%3BWacholder%2C+Sholom%3BJeronimo%2C+Jos%C3%A9%3BWheeler%2C+Cosette+M%3BCastle%2C+Philip+E&rft.aulast=Kreimer&rft.aufirst=Aim%C3%A9e&rft.date=2006-05-01&rft.volume=15&rft.issue=5&rft.spage=908&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A reproducibility study for a fluoride assay in bone. AN - 67974723; 16702389 AB - Osteosarcoma is a rare malignancy of largely unknown etiology. Although there is no consistent evidence for an association between fluoridation and cancer, some concerns remain about osteosarcoma. As part of the design of a collaborative study, bone samples were collected to allow for an evaluation of the association between osteosarcoma risk and individual fluoride exposure measured by levels of fluoride in bone. In this report, we provide the results of pilot experiments to consider issues that arose during the study design and to assess the reliability of the bone assays. Correlations of fluoride levels between normal bone near the affected area and iliac crest bone were strong and positive. The day-to-day laboratory analysis of fluoride in human and deer jaw bone yielded acceptable average coefficients of variation below 10% and an overall estimate of 5%. The intraclass correlation (ICC) is of particular importance to epidemiologists because it indicates the effect of measurement error on study results. Here, the estimated ICC is 0.86, and the estimated downward bias is only 14%. Hence, the ICC is strong enough so that the estimates of the relative risk will suffer little attenuation from lab measurements. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Medina, Nancy AU - Douglass, Chester W AU - Whitford, Gary M AU - Hoover, Robert N AU - Fears, Thomas R AD - NIH/National Cancer Institute, Biostatistics Branch, EPN 403, 6130 Executive Boulevard, MSC 7368, Bethesda, MD 20892-7368, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1035 EP - 1037 VL - 15 IS - 5 SN - 1055-9965, 1055-9965 KW - Fluorides KW - Q80VPU408O KW - Index Medicus KW - Animals KW - Osteosarcoma -- chemically induced KW - Reproducibility of Results KW - Bone Neoplasms -- chemically induced KW - Risk Factors KW - Humans KW - Jaw KW - Least-Squares Analysis KW - Pilot Projects KW - Deer KW - Fluorides -- analysis KW - Ilium KW - Fluorides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67974723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=A+reproducibility+study+for+a+fluoride+assay+in+bone.&rft.au=Medina%2C+Nancy%3BDouglass%2C+Chester+W%3BWhitford%2C+Gary+M%3BHoover%2C+Robert+N%3BFears%2C+Thomas+R&rft.aulast=Medina&rft.aufirst=Nancy&rft.date=2006-05-01&rft.volume=15&rft.issue=5&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco smoking and colorectal hyperplastic and adenomatous polyps. AN - 67974471; 16702367 AB - Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer. Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent. To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hyperplastic or adenomatous) polyps of the distal colon (descending colon, sigmoid, and rectum) with tobacco use among 33,667 subjects who were endoscopy negative for distal colon tumors, in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Trial, a randomized trial of flexible sigmoidoscopy. Risks, estimated by the odds ratio (OR), associated with current cigarette use were OR = 4.4 [95% confidence interval (95% CI), 3.7-5.2] for hyperplastic polyps only, OR = 1.8 (95% CI, 1.5-2.1) for adenomas only, and OR = 6.2 (95% CI, 4.7-8.3) for subjects with both hyperplastic and adenomatous polyps concurrently. Effects were weaker among ex smokers; the smoking-associated ORs remained consistently higher for hyperplastic polyps. This pattern was also seen in relation to cigarettes smoked per day, smoking duration, and pack-years. Tobacco-associated risks for multiple polyps were also stronger when hyperplastic disease was involved. In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Ji, Bu-Tian AU - Weissfeld, Joel L AU - Chow, Wong-Ho AU - Huang, Wen-Yi AU - Schoen, Robert E AU - Hayes, Richard B AD - National Cancer Institute, 6120 Executive Boulevard, EPS 8120, Bethesda, MD 20852, USA. jib@exchange.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 897 EP - 901 VL - 15 IS - 5 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Sigmoidoscopy KW - Odds Ratio KW - Hyperplasia KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Confidence Intervals KW - Middle Aged KW - Male KW - Female KW - Adenomatous Polyposis Coli -- epidemiology KW - Adenomatous Polyposis Coli -- etiology KW - Smoking -- adverse effects KW - Colorectal Neoplasms -- etiology KW - Colorectal Neoplasms -- epidemiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67974471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Tobacco+smoking+and+colorectal+hyperplastic+and+adenomatous+polyps.&rft.au=Ji%2C+Bu-Tian%3BWeissfeld%2C+Joel+L%3BChow%2C+Wong-Ho%3BHuang%2C+Wen-Yi%3BSchoen%2C+Robert+E%3BHayes%2C+Richard+B&rft.aulast=Ji&rft.aufirst=Bu-Tian&rft.date=2006-05-01&rft.volume=15&rft.issue=5&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of the granzyme B ELISPOT assay for monitoring cancer vaccine trials. AN - 67968331; 16699376 AB - Granzyme B (GrB) is present in the granules of cytolytic lymphocytes and is a key mediator of cell-mediated target cell death via the granule-mediated pathway. The release of GrB can be used as an indicator of a cytotoxic T lymphocyte response. Herein, we report that the GrB enzyme-linked immunospot assay (ELISPOT) can be used to measure ex vivo antigen-specific cytotoxicity of peripheral blood mononuclear cells from cancer patients vaccinated with a peptide-based cancer vaccine. We compare the reactivity of patients' peripheral blood mononuclear cells in the GrB ELISPOT with reactivity in the tetramer, interferon (IFN)-gamma ELISPOT, and Cr-release assays. Differences in immune response over all assays tested were found between patients and 4 response patterns were observed. Reactivity in the GrB ELISPOT was more closely associated with cytotoxicity in the Cr-release assay than the tetramer or IFN-gamma ELISPOT assays. Moreover, the higher affinity g209-2M peptide (used for vaccination) elicited greater GrB secretion than the native g209 peptide, although this difference was not observed with IFN-gamma secretion. Taken together with the fact that GrB is a specific mediator released by cytotoxic T lymphocytes, these results show that simultaneous use of the GrB ELISPOT assay with other immunologic assays may provide important additional immunologic insight into patient responses to cancer vaccines. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Shafer-Weaver, Kimberly AU - Rosenberg, Steven AU - Strobl, Susan AU - Gregory Alvord, W AU - Baseler, Michael AU - Malyguine, Anatoli AD - Laboratory of Cell-mediated Immunity, SAIC-Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA. PY - 2006 SP - 328 EP - 335 VL - 29 IS - 3 SN - 1524-9557, 1524-9557 KW - Antigens KW - 0 KW - Cancer Vaccines KW - Membrane Glycoproteins KW - PMEL protein, human KW - Peptides KW - g209-2M melanoma peptide KW - gp100 Melanoma Antigen KW - Interferon-gamma KW - 82115-62-6 KW - GZMB protein, human KW - EC 3.4.21.- KW - Granzymes KW - Serine Endopeptidases KW - Index Medicus KW - Membrane Glycoproteins -- chemistry KW - Cytotoxicity Tests, Immunologic -- methods KW - Humans KW - Leukocytes, Mononuclear -- metabolism KW - Interferon-gamma -- metabolism KW - Peptides -- chemistry KW - Antigens -- chemistry KW - Models, Statistical KW - Immune System KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Cancer Vaccines -- chemistry KW - Serine Endopeptidases -- chemistry KW - Melanoma -- blood KW - Melanoma -- therapy KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67968331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Application+of+the+granzyme+B+ELISPOT+assay+for+monitoring+cancer+vaccine+trials.&rft.au=Shafer-Weaver%2C+Kimberly%3BRosenberg%2C+Steven%3BStrobl%2C+Susan%3BGregory+Alvord%2C+W%3BBaseler%2C+Michael%3BMalyguine%2C+Anatoli&rft.aulast=Shafer-Weaver&rft.aufirst=Kimberly&rft.date=2006-05-01&rft.volume=29&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A compilation of two decades of mutagenicity test results with the Ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays. AN - 67967821; 16696565 AB - As previously reported [Cameron, T. P., Rogers-Back, A. M., Lawlor, T. E., Harbell, J. W., Seifried, H. E., and Dunkel, V. C. (1991) Gentoxicity of multifunctional acrylates in the Salmonella/mammalian-microsome assay and mouse lymphoma TK+/- assay. Environ. Mol. Mutagen. 17, 264-271], the National Cancer Institute (NCI) shares the responsibility of selecting the most significant chemicals for carcinogenicity testing by the National Toxicology Program (NTP) and has used data from Salmonella and mouse lymphoma mutagenicity assays to aid in the selection and prioritization of chemicals to be further evaluated in chronic 2 year rodent studies. In addition, a number of antineoplastic and anti-AIDS drugs in preclinical evaluation were tested for the NCI's Division of Cancer Treatment Toxicology Branch. In the NCI/NTP chemical selection process, it is no longer necessary to test chemicals prior to sending them to the NTP so the NCI program has ceased performing mutagenicity tests. Some of the testing data has been made available in summary form in the Chemical Carcinogenisis Research Information System (CCRIS), which is searchable on the NLM TOXNET system. The limitations in using this source are that only summary results are available and many negative test results are not included. A summary table that presents the results for each compound is provided in the Appendix with raw data provided in the Supporting Information. The Appendix table contains the compound name, CAS number, and a summary of the data from the Ames test and the mouse lymphoma assay. JF - Chemical research in toxicology AU - Seifried, H E AU - Seifried, R M AU - Clarke, J J AU - Junghans, T B AU - San, R H C AD - Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 627 EP - 644 VL - 19 IS - 5 SN - 0893-228X, 0893-228X KW - Mutagens KW - 0 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Tumor Cells, Cultured -- drug effects KW - Drug-Related Side Effects and Adverse Reactions KW - Mice KW - Mutagens -- toxicity KW - Salmonella typhimurium -- drug effects KW - Data Collection KW - Leukemia L5178 KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67967821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=A+compilation+of+two+decades+of+mutagenicity+test+results+with+the+Ames+Salmonella+typhimurium+and+L5178Y+mouse+lymphoma+cell+mutation+assays.&rft.au=Seifried%2C+H+E%3BSeifried%2C+R+M%3BClarke%2C+J+J%3BJunghans%2C+T+B%3BSan%2C+R+H+C&rft.aulast=Seifried&rft.aufirst=H&rft.date=2006-05-01&rft.volume=19&rft.issue=5&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Chem Res Toxicol. 2008 Feb;21(2):554-5 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone). AN - 67938881; 16675588 AB - Because ribonucleotide reductase (RR) plays a role in DNA repair, it may serve as a molecular target for radiosensitization. Unlike previously investigated RR inhibitors, Triapine potently inhibits both RR holoenzymes. Therefore, the effects of Triapine on tumor cell radiosensitivity were investigated. The effects of Triapine on the in vitro radiosensitivity of three human tumor cell lines and one normal cell line were evaluated using a clonogenic assay. Growth delay was used to evaluate the effects of Triapine on in vivo tumor radiosensitivity. The levels of the RR subunits were determined using immunoblot analysis and DNA damage and repair were evaluated using gammaH2AX foci. Exposure of the tumor cell lines to Triapine before or immediately after irradiation resulted in an increase in radiosensitivity. In contrast, Triapine enhanced the radiosensitivity of the normal fibroblast cell line only when the exposure was before irradiation. There were no consistent differences between cell lines with respect to the expression of the RR subunits. Whereas Triapine had no effect on radiation-induced gammaH2AX foci at 1 hour, the number of gammaH2AX foci per cell was significantly greater in the Triapine-treated cells at 24 hours after irradiation, suggesting the presence of unrepaired DNA damage. Triapine administration to mice bearing tumor xenografts immediately after irradiation resulted in a greater than additive increase in radiation-induced tumor growth delay. These results indicate that Triapine can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect involves an inhibition of DNA repair. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Barker, Christopher A AU - Burgan, William E AU - Carter, Donna J AU - Cerna, David AU - Gius, David AU - Hollingshead, Melinda G AU - Camphausen, Kevin AU - Tofilon, Philip J AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 2912 EP - 2918 VL - 12 IS - 9 SN - 1078-0432, 1078-0432 KW - Enzyme Inhibitors KW - 0 KW - Pyridines KW - Radiation-Sensitizing Agents KW - Thiosemicarbazones KW - 3-aminopyridine-2-carboxaldehyde thiosemicarbazone KW - 143621-35-6 KW - Ribonucleotide Reductases KW - EC 1.17.4.- KW - Index Medicus KW - Pancreatic Neoplasms KW - Humans KW - Ribonucleotide Reductases -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Cell Line, Tumor KW - Glioma KW - Dose-Response Relationship, Radiation KW - Prostatic Neoplasms KW - Male KW - Radiation-Sensitizing Agents -- pharmacology KW - Thiosemicarbazones -- pharmacology KW - Cell Cycle -- radiation effects KW - Pyridines -- pharmacology KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67938881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=In+vitro+and+in+vivo+radiosensitization+induced+by+the+ribonucleotide+reductase+inhibitor+Triapine+%283-aminopyridine-2-carboxaldehyde-thiosemicarbazone%29.&rft.au=Barker%2C+Christopher+A%3BBurgan%2C+William+E%3BCarter%2C+Donna+J%3BCerna%2C+David%3BGius%2C+David%3BHollingshead%2C+Melinda+G%3BCamphausen%2C+Kevin%3BTofilon%2C+Philip+J&rft.aulast=Barker&rft.aufirst=Christopher&rft.date=2006-05-01&rft.volume=12&rft.issue=9&rft.spage=2912&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-21 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epidermal barrier formation and recovery in skin disorders. AN - 67935937; 16670755 AB - Skin is at the interface between the complex physiology of the body and the external, often hostile, environment, and the semipermeable epidermal barrier prevents both the escape of moisture and the entry of infectious or toxic substances. Newborns with rare congenital barrier defects underscore the skin's essential role in a terrestrial environment and demonstrate the compensatory responses evoked ex utero to reestablish a barrier. Common inflammatory skin disorders such as atopic dermatitis and psoriasis exhibit decreased barrier function, and recent studies suggest that the complex response of epidermal cells to barrier disruption may aggravate, maintain, or even initiate such conditions. Either aiding barrier reestablishment or dampening the epidermal stress response may improve the treatment of these disorders. This Review discusses the molecular regulation of the epidermal barrier as well as causes and potential treatments for defects of barrier formation and proposes that medical management of barrier disruption may positively affect the course of common skin disorders. JF - The Journal of clinical investigation AU - Segre, Julia A AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-4442, USA. jsegre@nhgri.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1150 EP - 1158 VL - 116 IS - 5 SN - 0021-9738, 0021-9738 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Cell Differentiation KW - Models, Biological KW - Models, Anatomic KW - Epidermis -- physiology KW - Skin Diseases -- genetics KW - Epidermis -- pathology KW - Skin Diseases -- physiopathology KW - Skin Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67935937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Epidermal+barrier+formation+and+recovery+in+skin+disorders.&rft.au=Segre%2C+Julia+A&rft.aulast=Segre&rft.aufirst=Julia&rft.date=2006-05-01&rft.volume=116&rft.issue=5&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-14 N1 - Date created - 2006-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Allergy Asthma Rep. 2004 Jul;4(4):276-84 [15175141] J Clin Invest. 2004 Jun;113(12):1664-75 [15199399] J Pediatr. 2004 Jul;145(1):82-92 [15238912] Hum Mol Genet. 2004 Oct 15;13(20):2473-82 [15317751] EMBO J. 2005 Mar 23;24(6):1146-56 [15775979] J Immunol. 2005 Jun 15;174(12):8183-90 [15944327] J Clin Invest. 2005 Jul;115(7):1777-84 [16007253] J Cell Biol. 2005 Aug 1;170(3):487-96 [16061697] Genome Res. 2005 Aug;15(8):1051-60 [16024817] J Exp Med. 2005 Aug 15;202(4):541-9 [16103410] Dev Biol. 2005 Sep 1;285(1):28-37 [16039642] Nature. 2005 Sep 15;437(7057):369-75 [16163348] J Exp Med. 2005 Sep 19;202(6):829-39 [16172260] Nat Immunol. 2005 Oct;6(10):1047-53 [16142237] Nat Med. 2005 Dec;11(12):1351-4 [16288281] Nature. 2005 Dec 8;438(7069):803-19 [16341006] Hum Mol Genet. 2006 Mar 1;15(5):767-76 [16436457] Hum Genet. 2006 Mar;119(1-2):113-25 [16362825] Nat Genet. 2006 Mar;38(3):337-42 [16444271] Nat Genet. 2006 Apr;38(4):441-6 [16550169] J Clin Invest. 2006 May;116(5):1243-53 [16628254] J Am Acad Dermatol. 2003 Mar;48(3):352-8 [12637914] Nat Genet. 2000 Jun;25(2):141-2 [10835624] J Cell Biol. 2000 Oct 16;151(2):389-400 [11038185] Nat Genet. 2001 Oct;29(2):175-8 [11544479] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13031-6 [11698679] Hum Mol Genet. 2002 Jan 1;11(1):107-13 [11773004] J Clin Invest. 2002 Jan;109(2):243-50 [11805136] J Cell Biol. 2002 Mar 18;156(6):1099-111 [11889141] Nat Rev Genet. 2002 Mar;3(3):199-209 [11972157] Trends Cell Biol. 2002 Apr;12(4):185-92 [11978538] Oncogene. 2002 May 23;21(23):3765-79 [12032844] J Invest Dermatol. 2002 Jun;118(6):1073-9 [12060405] Nat Immunol. 2002 Jul;3(7):673-80 [12055625] Bioessays. 2002 Sep;24(9):789-800 [12210515] Science. 2002 Oct 25;298(5594):799-804 [12399584] J Invest Dermatol. 2003 Feb;120(2):224-8 [12542526] Mamm Genome. 2003 Feb;14(2):140-8 [12584609] J Invest Dermatol. 2003 Mar;120(3):456-64 [12603860] Physiol Genomics. 2003 Mar 18;13(1):69-78 [12644634] J Histochem Cytochem. 2003 May;51(5):675-85 [12704215] Development. 2003 Jun;130(12):2767-77 [12736219] Hum Mol Genet. 2003 Sep 15;12(18):2369-78 [12915478] Nat Genet. 2003 Nov;35(3):238-45 [14517554] J Clin Invest. 2003 Nov;112(9):1372-82 [14597763] Curr Opin Cell Biol. 2003 Dec;15(6):776-82 [14644205] Nat Genet. 2003 Dec;35(4):349-56 [14608357] J Allergy Clin Immunol. 2003 Dec;112(6 Suppl):S118-27 [14657842] J Clin Invest. 2004 Mar;113(5):651-7 [14991059] EMBO J. 2004 Apr 21;23(8):1770-81 [15057277] J Cell Biol. 2000 Oct 16;151(2):F5-8 [11038193] J Invest Dermatol. 2000 Dec;115(6):1072-81 [11121144] Science. 2001 Feb 2;291(5505):881-4 [11157169] Nat Genet. 2001 Apr;27(4):372-3 [11279517] J Invest Dermatol. 2001 May;116(5):728-30 [11348461] Allergy. 2001 Sep;56(9):813-24 [11551246] Science. 2004 Oct 22;306(5696):636-40 [15499007] Am J Med Genet C Semin Med Genet. 2004 Nov 15;131C(1):32-44 [15452860] J Invest Dermatol. 1983 Jun;80 Suppl:44s-49s [6189923] Arch Dermatol. 1985 Apr;121(4):477-88 [3977371] J Clin Invest. 1991 May;87(5):1668-73 [2022737] J Clin Invest. 1992 Aug;90(2):482-7 [1644919] J Clin Invest. 1993 Jun;91(6):2703-8 [8514877] J Am Acad Dermatol. 1994 Apr;30(4):535-46 [7512582] Science. 1995 Jan 27;267(5197):525-8 [7824952] J Clin Invest. 1995 May;95(5):2281-90 [7738193] Nat Genet. 1995 Mar;9(3):279-83 [7773290] J Invest Dermatol. 1996 Mar;106(3):397-403 [8648167] J Invest Dermatol. 1996 Oct;107(4):558-64 [8823361] Arch Dermatol. 1996 Dec;132(12):1453-8 [8961874] Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1044-9 [9448282] Development. 1998 Apr;125(8):1541-52 [9502735] J Clin Invest. 1998 Apr 15;101(8):1614-22 [9541491] J Invest Dermatol. 1998 Jul;111(1):72-6 [9665389] J Invest Dermatol. 1998 Aug;111(2):320-6 [9699737] J Invest Dermatol. 1998 Sep;111(3):440-4 [9740238] J Invest Dermatol. 1999 Mar;112(3):354-61 [10084314] Exp Mol Med. 1999 Mar 31;31(1):5-19 [10231017] Nat Genet. 1999 Aug;22(4):356-60 [10431239] EMBO J. 2004 Nov 10;23(22):4517-25 [15510217] Nat Rev Immunol. 2004 Dec;4(12):978-88 [15573132] Genome Res. 2004 Dec;14(12):2430-8 [15574822] Nat Genet. 2005 Jan;37(1):56-65 [15619623] Lab Invest. 2005 Jan;85(1):109-23 [15558059] Mol Cell. 2005 Jan 7;17(1):1-10 [15629712] Nat Med. 2005 Jan;11(1):43-9 [15592573] Clin Dermatol. 2005 Jan-Feb;23(1):23-32 [15708286] Am J Hum Genet. 2005 May;76(5):794-803 [15756637] Science. 2005 Apr 15;308(5720):411-3 [15831758] Am J Respir Cell Mol Biol. 2005 May;32(5):428-35 [15731505] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minimal residual disease in hairy cell leukemia patients assessed by clone-specific polymerase chain reaction. AN - 67935272; 16675574 AB - Cladribine induces long-term complete remission in hairy cell leukemia (HCL) patients but does not clear minimal residual disease (MRD) according to high-sensitivity PCR assays. To quantify MRD in patients after anti-CD22 recombinant immunotoxin BL22 and other agents, we used a relative quantitative PCR (RQ-PCR) assay using a primer and probe, both patient specific for the immunoglobulin heavy chain rearrangement. Using this method, we were able to detect one Bonna 12 HCL cell in either 10(6) Jurkat cells or in 10(6) normal mononuclear cells. We studied 84 samples from 10 patients, taken before or after treatment with BL22 and other agents. Patient-specific RQ-PCR was much more sensitive than flow cytometry, which in turn was (as recently reported) more sensitive than PCR using consensus primers. RQ-PCR was positive in 62 of 62 (100%) flow-positive samples in 10 patients and in 20 of 22 (91%) flow-negative samples in six patients. The relative level of MRD as quantified by RQ-PCR correlated with disease status and remission. Thus, patient-specific RQ-PCR is the most sensitive test for MRD in HCL patients and could be used to determine maximal response in patients obtaining multiple cycles of nonmyelotoxic biological treatment for this disease. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Arons, Evgeny AU - Margulies, Inger AU - Sorbara, Lynn AU - Raffeld, Mark AU - Stetler-Stevenson, Maryalice AU - Pastan, Ira AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 2804 EP - 2811 VL - 12 IS - 9 SN - 1078-0432, 1078-0432 KW - Antigens, CD KW - 0 KW - DNA Primers KW - Immunoglobulin Heavy Chains KW - Index Medicus KW - Base Sequence KW - Humans KW - Molecular Sequence Data KW - Antigens, CD -- genetics KW - Aged KW - Middle Aged KW - Immunoglobulin Heavy Chains -- genetics KW - Male KW - Cloning, Molecular KW - Leukemia, Hairy Cell -- blood KW - Neoplasm, Residual -- diagnosis KW - Polymerase Chain Reaction -- methods KW - Leukemia, Hairy Cell -- immunology KW - Leukemia, Hairy Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67935272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Minimal+residual+disease+in+hairy+cell+leukemia+patients+assessed+by+clone-specific+polymerase+chain+reaction.&rft.au=Arons%2C+Evgeny%3BMargulies%2C+Inger%3BSorbara%2C+Lynn%3BRaffeld%2C+Mark%3BStetler-Stevenson%2C+Maryalice%3BPastan%2C+Ira%3BKreitman%2C+Robert+J&rft.aulast=Arons&rft.aufirst=Evgeny&rft.date=2006-05-01&rft.volume=12&rft.issue=9&rft.spage=2804&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-21 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. AN - 67933188; 16675848 AB - It has been reported that extracellular matrix (ECM) molecules regulate monocyte activation by binding with a 67 kDa nonintegrin laminin receptor (LR). As microgliosis is a pivotal factor in propelling the progress of chronic neurodegeneration in the brain, we hypothesized that LR may regulate the microgliosis and subsequent neurotoxicity. Using 1-methyl-4-phenylpyridinium (MPP+) -treated C57 mice primary mesencephalic neuron-glia cultures as an in vitro Parkinson's disease (PD) model, we observed that MPP+ treatment increased LR expression only in the mixed neuron-glia but not in microglia-enriched or microglia-depleted cultures, indicating that MPP+-induced increase of LR expression is associated with neuron-microglia interaction. Using confocal microscopic examination, we found that LR was localized in the microglia, which were F4/80 positive. Treatment with the antibody (Ab) against LR (LR-Ab) or YIGSR, a synthetic pentapeptide inhibitor for LR, significantly attenuated the MPP+-increased F4/80 immunoreactivity (24 h) and dopaminergic (DA) neurotoxicity. LR-Ab also attenuated MPP+-increased microglial phagocytotic activity (48 h) and the superoxide production (4 days). Further study demonstrated that exogenous laminin (1-10 microg/ml) treatment induced microglial activation and DA neurotoxicity, in a dose-dependent manner, which was partially attenuated by the LR-Ab. We concluded that by regulating cell-ECM interaction, LR plays important roles in mediating microgliosis and subsequent DA neurotoxicity. Laminin is a potential ligand for activating this LR receptor. This study also suggests that laminin/LR is a potential target for developing new therapeutic drugs against neurodegenerative disorders such as PD. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Wang, Tongguang AU - Zhang, Wei AU - Pei, Zhong AU - Block, Michelle AU - Wilson, Belinda AU - Reece, Jeffrey M AU - Miller, David S AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park,North Carolina, USA. twang40@jhmi.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 906 EP - 915 VL - 20 IS - 7 KW - Antibodies KW - 0 KW - Laminin KW - Oligopeptides KW - Receptors, Laminin KW - tyrosyl-isoleucyl-glycyl-seryl-arginine KW - 110590-64-2 KW - Superoxides KW - 11062-77-4 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Animals KW - Superoxides -- metabolism KW - Antibodies -- metabolism KW - Cells, Cultured KW - Parkinson Disease -- metabolism KW - Oligopeptides -- pharmacology KW - Mice KW - Laminin -- pharmacology KW - Gliosis -- pathology KW - Gliosis -- metabolism KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Receptors, Laminin -- metabolism KW - Microglia -- pathology KW - Microglia -- drug effects KW - Neurons -- pathology KW - Microglia -- metabolism KW - 1-Methyl-4-phenylpyridinium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67933188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Reactive+microgliosis+participates+in+MPP%2B-induced+dopaminergic+neurodegeneration%3A+role+of+67+kDa+laminin+receptor.&rft.au=Wang%2C+Tongguang%3BZhang%2C+Wei%3BPei%2C+Zhong%3BBlock%2C+Michelle%3BWilson%2C+Belinda%3BReece%2C+Jeffrey+M%3BMiller%2C+David+S%3BHong%2C+Jau-Shyong&rft.aulast=Wang&rft.aufirst=Tongguang&rft.date=2006-05-01&rft.volume=20&rft.issue=7&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. AN - 67930855; 16651303 AB - Antenatal dexamethasone and betamethasone may not be equally efficacious in the prevention of adverse neonatal outcomes. We compared the risks of periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and neonatal death among very low birth weight infants who were exposed to dexamethasone, betamethasone, or neither steroid. Infants (401-1500 g) in the National Institute of Child Health and Human Development Neonatal Research Network were studied. Multivariate logistic regression analyses compared the 3 groups with regard to PVL, IVH, ROP, and neonatal death, adjusting for network center and selected covariates. A total of 3600 infants met entry criteria. Compared with no antenatal steroids, there were trends for a reduced risk for PVL associated with dexamethasone and betamethasone but no difference in risk between dexamethasone and betamethasone. Dexamethasone reduced the risk for IVH and severe IVH, compared with no antenatal steroid exposure. Betamethasone reduced the risk for IVH, severe IVH, and neonatal death, compared with no antenatal steroids. Compared with betamethasone, dexamethasone had a statistically significant increased risk for neonatal death. There were trends for greater risks associated with dexamethasone compared with betamethasone for IVH and severe ROP. Betamethasone was associated with a reduced risk for neonatal death, with trends of decreased risk for other adverse neonatal outcomes, compared with dexamethasone. It may be in the best interest of neonates to receive betamethasone rather than dexamethasone when available. JF - Pediatrics AU - Lee, Ben H AU - Stoll, Barbara J AU - McDonald, Scott A AU - Higgins, Rosemary D AU - National Institute of Child Health and Human Development Neonatal Research Network AD - Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. ben_lee@oz.ped.emory.edu ; National Institute of Child Health and Human Development Neonatal Research Network Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1503 EP - 1510 VL - 117 IS - 5 KW - Glucocorticoids KW - 0 KW - Dexamethasone KW - 7S5I7G3JQL KW - Betamethasone KW - 9842X06Q6M KW - Abridged Index Medicus KW - Index Medicus KW - Infant, Very Low Birth Weight KW - Cerebral Hemorrhage -- prevention & control KW - Leukomalacia, Periventricular -- prevention & control KW - Infant, Premature, Diseases -- prevention & control KW - Humans KW - Infant, Newborn KW - Infant Mortality KW - Retinopathy of Prematurity -- prevention & control KW - Betamethasone -- therapeutic use KW - Dexamethasone -- therapeutic use KW - Dexamethasone -- adverse effects KW - Lung -- drug effects KW - Lung -- embryology KW - Betamethasone -- adverse effects KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Fetal Organ Maturity -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Adverse+neonatal+outcomes+associated+with+antenatal+dexamethasone+versus+antenatal+betamethasone.&rft.au=Lee%2C+Ben+H%3BStoll%2C+Barbara+J%3BMcDonald%2C+Scott+A%3BHiggins%2C+Rosemary+D%3BNational+Institute+of+Child+Health+and+Human+Development+Neonatal+Research+Network&rft.aulast=Lee&rft.aufirst=Ben&rft.date=2006-05-01&rft.volume=117&rft.issue=5&rft.spage=1503&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. AN - 67925406; 16651436 AB - ATP-binding cassette (ABC) proteins include the best known mediators of resistance to anticancer drugs. In particular, ABCB1 [MDR1/P-glycoprotein (P-gp)] extrudes many types of drugs from cancer cells, thereby conferring resistance to those agents. Attempts to overcome P-gp-mediated drug resistance using specific inhibitors of P-gp has had limited success and has faced many therapeutic challenges. As an alternative approach to using P-gp inhibitors, we characterize a thiosemicarbazone derivative (NSC73306) identified in a generic screen as a compound that exploits, rather than suppresses, P-gp function to induce cytotoxicity. Cytotoxic activity of NSC73306 was evaluated in vitro using human epidermoid, ovarian, and colon cancer cell lines expressing various levels of P-gp. Our findings suggest that cells become hypersensitive to NSC73306 in proportion to the increased P-gp function and multidrug resistance (MDR). Abrogation of both sensitivity to NSC73306 and resistance to P-gp substrate anticancer agents occurred with specific inhibition of P-gp function using either a P-gp inhibitor (PSC833, XR9576) or RNA interference, suggesting that cytotoxicity was linked to MDR1 function, not to other, nonspecific factors arising during the generation of resistant or transfected cells. Molecular characterization of cells selected for resistance to NSC73306 revealed loss of P-gp expression and consequent loss of the MDR phenotype. Although hypersensitivity to NSC73306 required functional expression of P-gp, biochemical assays revealed no direct interaction between NSC73306 and P-gp. This article shows that NSC73306 kills cells with intrinsic or acquired P-gp-induced MDR and indirectly acts to eliminate resistance to MDR1 substrates. JF - Cancer research AU - Ludwig, Joseph A AU - Szakács, Gergely AU - Martin, Scott E AU - Chu, Benjamin F AU - Cardarelli, Carol AU - Sauna, Zuben E AU - Caplen, Natasha J AU - Fales, Henry M AU - Ambudkar, Suresh V AU - Weinstein, John N AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 4808 EP - 4815 VL - 66 IS - 9 SN - 0008-5472, 0008-5472 KW - Cyclosporins KW - 0 KW - Indoles KW - NSC73306 KW - P-Glycoprotein KW - RNA, Small Interfering KW - Doxorubicin KW - 80168379AG KW - valspodar KW - Q7ZP55KF3X KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Doxorubicin -- pharmacology KW - Humans KW - RNA, Small Interfering -- genetics KW - Drug Resistance, Neoplasm KW - Cell Line, Tumor KW - Cyclosporins -- pharmacology KW - Drug Synergism KW - Female KW - Ovarian Neoplasms -- metabolism KW - Carcinoma, Squamous Cell -- metabolism KW - Drug Resistance, Multiple -- drug effects KW - P-Glycoprotein -- biosynthesis KW - Ovarian Neoplasms -- drug therapy KW - P-Glycoprotein -- antagonists & inhibitors KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Ovarian Neoplasms -- pathology KW - Colonic Neoplasms -- drug therapy KW - Colonic Neoplasms -- metabolism KW - Indoles -- pharmacology KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67925406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Selective+toxicity+of+NSC73306+in+MDR1-positive+cells+as+a+new+strategy+to+circumvent+multidrug+resistance+in+cancer.&rft.au=Ludwig%2C+Joseph+A%3BSzak%C3%A1cs%2C+Gergely%3BMartin%2C+Scott+E%3BChu%2C+Benjamin+F%3BCardarelli%2C+Carol%3BSauna%2C+Zuben+E%3BCaplen%2C+Natasha+J%3BFales%2C+Henry+M%3BAmbudkar%2C+Suresh+V%3BWeinstein%2C+John+N%3BGottesman%2C+Michael+M&rft.aulast=Ludwig&rft.aufirst=Joseph&rft.date=2006-05-01&rft.volume=66&rft.issue=9&rft.spage=4808&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 2001 May 15;356(Pt 1):71-5 [11336637] Genome Res. 2001 Jul;11(7):1156-66 [11435397] Drug Metab Dispos. 2002 Jan;30(1):4-6 [11744604] Br J Cancer. 2001 Dec 14;85(12):1987-97 [11747344] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Lung. 2002;180(3):173-9 [12177731] Clin Cancer Res. 2003 Feb;9(2):827-36 [12576456] Cancer Res. 2003 Apr 1;63(7):1515-9 [12670898] J Med Chem. 2003 Nov 6;46(23):4805-17 [14584929] Cancer Res. 2003 Dec 15;63(24):8634-47 [14695175] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Anticancer Drugs. 2004 Oct;15(9):861-9 [15457126] Biochim Biophys Acta. 1976 Nov 11;455(1):152-62 [990323] Biochim Biophys Acta. 1976 Dec 14;455(3):900-12 [999943] Eur J Cancer. 1979 Apr;15(4):451-9 [436906] Somat Cell Mol Genet. 1985 Mar;11(2):117-26 [3856953] J Biol Chem. 1986 Jun 15;261(17):7762-70 [3711108] Cancer Res. 1986 Aug;46(8):4087-90 [3731076] Cell. 1986 Nov 7;47(3):371-80 [3768958] Proc Natl Acad Sci U S A. 1987 Jan;84(1):265-9 [2432605] Proc Natl Acad Sci U S A. 1987 May;84(9):3004-8 [3472246] Biochem Biophys Res Commun. 1990 Jan 15;166(1):180-6 [1967936] Cancer Res. 1990 Aug 1;50(15):4478-84 [2369726] Blood. 1991 Aug 1;78(3):586-92 [1859877] Cancer Res. 1991 Aug 15;51(16):4226-33 [1678313] Anticancer Res. 1991 May-Jun;11(3):1309-12 [1679619] J Biol Chem. 1992 Mar 5;267(7):4854-8 [1347044] Pharmazie. 1993 Sep;48(9):659-66 [8234398] J Clin Oncol. 1994 Nov;12(11):2453-9 [7964963] N Engl J Med. 1995 Nov 23;333(21):1380-5 [7477118] J Biol Chem. 1996 Jan 19;271(3):1708-16 [8576173] Br J Cancer. 1996 Apr;73(7):849-55 [8611394] Oncol Res. 1996;8(2):77-84 [8859778] Biochem Pharmacol. 1997 Sep 15;54(6):649-55 [9310341] Methods Mol Biol. 1998;79:179-83 [9463833] Biochemistry. 1998 Apr 7;37(14):5010-9 [9538020] J Natl Cancer Inst. 1998 Jun 3;90(11):862 [9625176] Methods Enzymol. 1998;292:492-504 [9711577] Br J Cancer. 1998 Dec;78(11):1464-70 [9836479] Cancer Biochem Biophys. 1998 Jun;16(1-2):85-110 [9923970] Annu Rev Pharmacol Toxicol. 1999;39:361-98 [10331089] Anticancer Drug Des. 1999 Apr;14(2):153-68 [10405642] Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):149-68 [11259838] Methods Cell Biol. 2001;64:211-33 [11070841] Br J Pharmacol. 1999 Sep;128(2):403-11 [10510451] Eur J Cancer. 2001 Mar;37(5):660-7 [11290442] J Biol Chem. 2001 Apr 13;276(15):11653-61 [11154703] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4628-33 [11274375] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in HIV risk behaviors among patients receiving combined pharmacological and behavioral interventions for heroin and cocaine dependence. AN - 67925393; 16085366 AB - Cocaine use is associated with injecting and sexual HIV risk behaviors. This study was a randomized controlled trial of behavioral interventions for cocaine dependence and HIV risk behaviors among dually (cocaine and heroin) dependent outpatients. Methadone maintenance was augmented with cognitive-behavioral therapy (CBT), contingency management (CM), both (CBT+CM), or neither. The study sample (n=81) was 52% female, 70% African American, and 37.9+/-7.0 years old. Proportions reporting HIV risk behaviors at intake were: 96.3% (78/81) injection drug use, 56.8% (46/81) sharing needles, 30.9% (25/81) unprotected sex, 28.4% (23/81) trading sex for money or drugs. Proportions who no longer reported behaviors at study exit were: 51.3% (40/78) injection drug use, 91.3% (42/46) sharing needles, 88% (22/25) unprotected sex, 91.3% (21/23) trading sex for money or drugs. Participants receiving CBT+CM were more likely to report cessation of unprotected sex relative to control (OR=5.44, 95% CI 1.14-26.0, p=0.034) but this effect was no longer significant after adjusting for drug-negative urines. These results suggest broad beneficial effects of methadone maintenance augmented with behavioral interventions for reducing HIV risk behaviors. JF - Addictive behaviors AU - Schroeder, Jennifer R AU - Epstein, David H AU - Umbricht, Annie AU - Preston, Kenzie L AD - Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. jschroed@intra.nida.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 868 EP - 879 VL - 31 IS - 5 SN - 0306-4603, 0306-4603 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Unsafe Sex KW - Methadone -- therapeutic use KW - Combined Modality Therapy KW - Substance Abuse, Intravenous -- rehabilitation KW - Humans KW - Sexual Behavior KW - Cognitive Therapy KW - Adult KW - Sex Work KW - Middle Aged KW - Needle Sharing -- adverse effects KW - Female KW - Male KW - Substance Abuse, Intravenous -- psychology KW - Risk-Taking KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Cocaine-Related Disorders -- psychology KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology KW - Heroin Dependence -- complications KW - HIV Infections -- psychology KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67925393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Changes+in+HIV+risk+behaviors+among+patients+receiving+combined+pharmacological+and+behavioral+interventions+for+heroin+and+cocaine+dependence.&rft.au=Schroeder%2C+Jennifer+R%3BEpstein%2C+David+H%3BUmbricht%2C+Annie%3BPreston%2C+Kenzie+L&rft.aulast=Schroeder&rft.aufirst=Jennifer&rft.date=2006-05-01&rft.volume=31&rft.issue=5&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. AN - 67924206; 16651618 AB - The membrane serine protease matriptase is required for epidermal barrier function, hair formation, and thymocyte development in mice, and dysregulated matriptase expression causes epidermal squamous cell carcinoma. To elucidate the specific functions of matriptase in normal and aberrant epidermal differentiation, we used enzymatic gene trapping combined with immunohistochemical, ultrastructural, and barrier function assays to delineate the spatio-temporal expression and function of matriptase in mouse keratinized tissue development, homeostasis, and malignant transformation. In the interfollicular epidermis, matriptase expression was restricted to postmitotic transitional layer keratinocytes undergoing terminal differentiation. Matriptase was also expressed in keratinizing oral epithelium, where it was required for oral barrier function, and in thymic epithelium. In all three tissues, matriptase colocalized with profilaggrin. In staged embryos, the onset of epidermal matriptase expression coincided with that of profilaggrin expression and acquisition of the epidermal barrier. In marked contrast to stratifying keritinized epithelium, matripase expression commenced already in undifferentiated and rapidly proliferating profilaggrin-negative matrix cells and displayed hair growth cycle-dependent expression. Exposure of the epidermis to carcinogens led to the gradual appearance of matriptase in a keratin-5-positive proliferative cell compartment during malignant progression. Combined with previous studies, these data suggest that matriptase has diverging functions in the genesis of stratified keratinized epithelium, hair follicles, and squamous cell carcinoma. JF - The American journal of pathology AU - List, Karin AU - Szabo, Roman AU - Molinolo, Alfredo AU - Nielsen, Boye Schnack AU - Bugge, Thomas H AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1513 EP - 1525 VL - 168 IS - 5 SN - 0002-9440, 0002-9440 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Intermediate Filament Proteins KW - KRT5 protein, human KW - Keratin-5 KW - filaggrin KW - Keratins KW - 68238-35-7 KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - matriptase KW - Abridged Index Medicus KW - Index Medicus KW - Keratins -- metabolism KW - Animals KW - Embryo, Mammalian -- physiology KW - Hair Follicle -- metabolism KW - Thymus Gland -- metabolism KW - Epidermis -- metabolism KW - Carcinogens -- toxicity KW - Embryo, Mammalian -- enzymology KW - Cell Differentiation KW - Mice KW - Stem Cells -- physiology KW - Mice, Transgenic KW - Cell Proliferation KW - Intermediate Filament Proteins -- metabolism KW - Epidermis -- drug effects KW - Embryo, Mammalian -- cytology KW - beta-Galactosidase -- genetics KW - Epidermis -- enzymology KW - Immunohistochemistry KW - Cell Line KW - Serine Endopeptidases -- physiology KW - Carcinoma, Squamous Cell -- enzymology KW - Hair -- growth & development KW - Serine Endopeptidases -- metabolism KW - Serine Endopeptidases -- genetics KW - Epithelium -- physiology KW - Biomarkers, Tumor -- analysis KW - Epithelium -- enzymology KW - Carcinoma, Squamous Cell -- metabolism KW - Animals, Newborn -- metabolism KW - Animals, Newborn -- abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67924206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Delineation+of+matriptase+protein+expression+by+enzymatic+gene+trapping+suggests+diverging+roles+in+barrier+function%2C+hair+formation%2C+and+squamous+cell+carcinogenesis.&rft.au=List%2C+Karin%3BSzabo%2C+Roman%3BMolinolo%2C+Alfredo%3BNielsen%2C+Boye+Schnack%3BBugge%2C+Thomas+H&rft.aulast=List&rft.aufirst=Karin&rft.date=2006-05-01&rft.volume=168&rft.issue=5&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1995 Jul 28;270(30):17702-11 [7543090] Crit Rev Ther Drug Carrier Syst. 1991;8(3):237-69 [1954652] Biochem J. 1996 Jul 1;317 ( Pt 1):173-7 [8694761] Development. 1998 Apr;125(8):1541-52 [9502735] J Biol Chem. 1999 Jun 25;274(26):18231-6 [10373424] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11054-61 [10500122] J Invest Dermatol. 1999 Oct;113(4):523-32 [10504436] Hum Mol Genet. 2005 Jan 15;14(2):335-46 [15590704] Nat Genet. 2005 Jan;37(1):56-65 [15619623] Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40 [15803139] Br J Cancer. 2005 Jun 20;92(12):2171-80 [15928670] Hum Pathol. 2005 Jun;36(6):626-33 [16021568] J Cell Biol. 2005 Aug 1;170(3):487-96 [16061697] Genes Dev. 2005 Aug 15;19(16):1934-50 [16103220] Exp Dermatol. 2005 Oct;14(10):719-26 [16176279] Differentiation. 1986;31(1):67-77 [2426153] FASEB J. 2000 Feb;14(2):319-32 [10657988] J Biol Chem. 2000 Nov 24;275(47):36720-5 [10962009] Tumour Biol. 2001 Mar-Apr;22(2):104-14 [11125283] Crit Rev Oral Biol Med. 2000;11(4):383-408 [11132762] Biochim Biophys Acta. 2001 Mar 19;1518(1-2):204-9 [11267681] Am J Pathol. 2001 Apr;158(4):1301-11 [11290548] J Invest Dermatol. 2001 Jul;117(1):3-15 [11442744] Nat Rev Genet. 2002 Mar;3(3):199-209 [11972157] Oncogene. 2002 May 23;21(23):3765-79 [12032844] Trends Immunol. 2002 Jul;23(7):364-71 [12103357] J Invest Dermatol. 2002 Nov;119(5):1137-49 [12445204] Clin Exp Metastasis. 2002;19(7):639-49 [12498394] Cancer Res. 2003 Mar 1;63(5):1101-5 [12615728] Biol Chem. 2003 Feb;384(2):257-66 [12675519] Nat Rev Cancer. 2003 Jun;3(6):434-43 [12778133] Nat Rev Cancer. 2003 Jun;3(6):444-51 [12778134] J Histochem Cytochem. 2003 Aug;51(8):1017-25 [12871983] Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11830-5 [12913119] Cancer. 2003 Nov 1;98(9):1898-904 [14584072] Br J Dermatol. 2004 Feb;150(2):195-204 [14996088] J Biol Chem. 2004 Apr 9;279(15):14899-908 [14747469] Chest. 2004 May;125(5):1843-52 [15136399] Int J Dev Biol. 2004;48(2-3):163-70 [15272381] Anat Rec A Discov Mol Cell Evol Biol. 2004 Aug;279(2):740-8 [15278945] Int J Cancer. 2004 Oct 20;112(1):14-25 [15305371] Prostate. 2004 Nov 1;61(3):228-35 [15368474] Genes Dev. 2004 Oct 1;18(19):2354-8 [15466487] J Cell Biol. 1984 Oct;99(4 Pt 1):1372-8 [6480697] J Cell Biol. 2003 Nov 24;163(4):901-10 [14638864] Curr Opin Cell Biol. 2003 Dec;15(6):776-82 [14644205] J Immunol. 2004 Jan 1;172(1):617-24 [14688374] J Cell Biol. 1986 Dec;103(6 Pt 2):2593-606 [2432071] J Dermatol Sci. 1995 Nov;10(3):229-32 [8593266] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. AN - 67923453; 16651631 AB - We have used a recently described model in which a ras oncogene is expressed in cytokeratin 5 (K5)-expressing cells on doxycycline administration to explore the effects of this oncogene in salivary glands of adult mice. Inducible expression of a mutated K-ras gene under the control of the K5 promoter led to the development of hyperplastic and dysplastic epithelial lesions and carcinomas, with an incidence of 100% and a minimum latency of a week. All major salivary glands were affected, as well as a set of previously undescribed buccal accessory salivary glands located on the apex of the masseter muscle, close to the oral angle. The tumors appear to arise from the cytokeratin 5-positive basal cell compartment. Myoepithelial cells participated in the hyperplasias but not in carcinomas, because the tumors are negative for smooth muscle actin. Carcinomas did not accumulate immunoreactive p53 but are positive for p63, as assayed by immunohistochemistry using an antibody against the N terminus of DeltaN p63, a splice variant of p63 that can inhibit p53 transcriptional activity. In this study, we provide evidence that the ras oncogene, targeted to a specifically sensitive cell compartment within the salivary glands, can trigger a series of event that are sufficient for full carcinogenesis. JF - The American journal of pathology AU - Raimondi, Ana R AU - Vitale-Cross, Lynn AU - Amornphimoltham, Panomwat AU - Gutkind, J Silvio AU - Molinolo, Alfredo AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-4340, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1654 EP - 1665 VL - 168 IS - 5 SN - 0002-9440, 0002-9440 KW - Keratins KW - 68238-35-7 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Submandibular Gland -- pathology KW - Mouth Mucosa -- pathology KW - Mice KW - Cheek -- pathology KW - Mice, Transgenic KW - Cell Proliferation KW - Male KW - Female KW - Keratins -- genetics KW - Genes, ras KW - Gene Expression Regulation, Neoplastic KW - Fibroadenoma -- pathology KW - Carcinoma -- pathology KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Salivary Glands -- metabolism KW - Salivary Gland Neoplasms -- genetics KW - Salivary Gland Neoplasms -- pathology KW - Carcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67923453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Rapid+development+of+salivary+gland+carcinomas+upon+conditional+expression+of+K-ras+driven+by+the+cytokeratin+5+promoter.&rft.au=Raimondi%2C+Ana+R%3BVitale-Cross%2C+Lynn%3BAmornphimoltham%2C+Panomwat%3BGutkind%2C+J+Silvio%3BMolinolo%2C+Alfredo&rft.aulast=Raimondi&rft.aufirst=Ana&rft.date=2006-05-01&rft.volume=168&rft.issue=5&rft.spage=1654&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lab Invest. 2000 Nov;80(11):1657-70 [11092526] Genes Dev. 1992 Mar;6(3):345-55 [1372276] Virchows Arch A Pathol Anat Histopathol. 1992;421(2):105-13 [1325087] Semin Cancer Biol. 1992 Aug;3(4):241-7 [1421168] Lab Invest. 1993 Jul;69(1):24-42 [7687310] Int J Oral Maxillofac Surg. 1993 Dec;22(6):359-61 [8106812] Int J Cancer. 1994 May 1;57(3):362-4 [8168996] Differentiation. 1994 Nov;58(1):53-64 [7532601] Lab Invest. 1995 Mar;72(3):283-90 [7534850] Cell Growth Differ. 1995 Jun;6(6):737-48 [7669729] Crit Rev Oncol Hematol. 1997 Jul;26(2):65-75 [9298325] Carcinogenesis. 1998 Mar;19(3):529-31 [9525291] Mol Cell. 1998 Sep;2(3):305-16 [9774969] Oncogene. 1998 Nov 26;17(21):2711-7 [9840935] Cancer Res. 2004 Dec 15;64(24):8804-7 [15604235] Head Neck. 2005 Aug;27(8):696-702 [16021638] Oral Dis. 2002 Sep;8(5):229-40 [12363107] J Histochem Cytochem. 2003 Feb;51(2):133-9 [12533521] Nature. 2003 Apr 3;422(6931):494 [12673242] Virchows Arch. 2003 Aug;443(2):122-32 [12884041] Virchows Arch. 2004 Apr;444(4):332-9 [14997391] Cancer Lett. 2004 Oct 8;214(1):35-41 [15331171] J Oral Pathol. 1984 Dec;13(6):686-91 [6440961] Proc Natl Acad Sci U S A. 1987 Mar;84(5):1299-303 [3469670] Cell. 1987 May 22;49(4):465-75 [3032456] Proc Natl Acad Sci U S A. 1988 Jan;85(2):477-81 [3422439] Cell. 1988 Nov 18;55(4):619-25 [3180222] Genes Chromosomes Cancer. 1989 Sep;1(1):59-66 [2562114] Oncogene. 2001 Mar 22;20(12):1445-54 [11313888] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in neurologic function tests may predict neurotoxicity caused by ixabepilone. AN - 67919423; 16648510 AB - To investigate baseline factors and neurologic function tests (NFTs) that may predict the development of grade 2 or higher peripheral neuropathy (PN) after treatment with ixabepilone, an epothilone microtubule-stabilizing agent with antitumor activity. Advanced breast cancer patients were treated with ixabepilone (6 mg/m2) for 5 consecutive days every 3 weeks in a phase II clinical trial. Physical examinations, questionnaires, nerve conduction studies, and NFTs, including the Jebsen Test of Hand Function (JTH) and the Grooved Pegboard Test (GPT), were performed at baseline and during subsequent cycles. Forty-seven patients assessable for PN received a median of five cycles of therapy (range, one to 22 cycles). Nine of these patients developed grade 2 PN, and two developed grade 3 PN, with a median time to onset of 144 days (range, 6 to 189 days). Among these 11 patients, PN resolved in eight patients, with a median of 15 days (range, 6 to 346 days) after onset, but PN did not resolve in three patients during follow-ups at 76, 361, and 746 days after onset. GPT and changes of JTH scores at onset of PN were significantly different between patients with and without PN at comparable follow-up times (P = .006 and P = .002, respectively). Changes in GPT and JTH scores over the first two cycles were often associated with the development of PN by exploratory actuarial analysis. Serious ixabepilone-induced neuropathy was relatively rare on the treatment schedule used. NFTs, such as JTH and GPT, may have utility for predicting PN, but further testing is needed. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Lee, James J AU - Low, Jennifer A AU - Croarkin, Earllaine AU - Parks, Rebecca AU - Berman, Arlene W AU - Mannan, Nitin AU - Steinberg, Seth M AU - Swain, Sandra M AD - Cancer Therapeutics Branch, Medical Oncology Clinical Research Unit, and Biostatistics and Data Management Section, Center for Cancer Research, Cancer Therapy Evaluation Program, National Institutes of Health, Bethesda, MD 20889-5015, USA. Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 2084 EP - 2091 VL - 24 IS - 13 KW - Antineoplastic Agents KW - 0 KW - Epothilones KW - ixabepilone KW - K27005NP0A KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- physiopathology KW - Epothilones -- adverse effects KW - Peripheral Nervous System Diseases -- chemically induced KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67919423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Changes+in+neurologic+function+tests+may+predict+neurotoxicity+caused+by+ixabepilone.&rft.au=Lee%2C+James+J%3BLow%2C+Jennifer+A%3BCroarkin%2C+Earllaine%3BParks%2C+Rebecca%3BBerman%2C+Arlene+W%3BMannan%2C+Nitin%3BSteinberg%2C+Seth+M%3BSwain%2C+Sandra+M&rft.aulast=Lee&rft.aufirst=James&rft.date=2006-05-01&rft.volume=24&rft.issue=13&rft.spage=2084&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-12 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin. AN - 67915579; 16648292 AB - We have shown that thyroglobulin (Tg) is a potent autocrine regulator of thyroid-specific gene expression, and proposed that the accumulated follicular Tg within the colloid is a major factor in determining follicular function. In the present report, we examined the effect of Tg on the action of TSH/cAMP and iodine with special focus on the regulation of basolateral and apical iodide transporters; the sodium/iodide symporter (NIS) and the pendred syndrome gene (PDS) by Tg. We show that expression of NIS and PDS are differentially regulated by Tg concentration and exposure time. In addition, we found that PDS gene was induced by TSH/cAMP and iodide in the presence of Tg. Based on these results, we propose a model for the physiological turnover of follicular function that is dynamically regulated by Tg. JF - The Journal of endocrinology AU - Suzuki, Koichi AU - Kohn, Leonard D AD - Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. koichis@nih.go.jp Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 247 EP - 255 VL - 189 IS - 2 SN - 0022-0795, 0022-0795 KW - Membrane Transport Proteins KW - 0 KW - RNA, Messenger KW - SLC26A4 protein, human KW - Symporters KW - sodium-iodide symporter KW - Thyrotropin KW - 9002-71-5 KW - Thyroglobulin KW - 9010-34-8 KW - Iodine KW - 9679TC07X4 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Iodine -- physiology KW - Biological Transport -- genetics KW - Cyclic AMP -- physiology KW - RNA, Messenger -- genetics KW - Models, Biological KW - Thyrotropin -- physiology KW - Rats KW - Cyclic AMP -- genetics KW - Signal Transduction -- physiology KW - Thyrotropin -- genetics KW - Ovarian Follicle -- physiology KW - Cells, Cultured KW - Signal Transduction -- genetics KW - Biological Transport -- physiology KW - Drug Synergism KW - Time Factors KW - Female KW - Thyroglobulin -- biosynthesis KW - Gene Expression Regulation -- physiology KW - Symporters -- genetics KW - Thyroglobulin -- physiology KW - Membrane Transport Proteins -- physiology KW - Symporters -- physiology KW - Membrane Transport Proteins -- genetics KW - Thyroglobulin -- genetics KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67915579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Differential+regulation+of+apical+and+basal+iodide+transporters+in+the+thyroid+by+thyroglobulin.&rft.au=Suzuki%2C+Koichi%3BKohn%2C+Leonard+D&rft.aulast=Suzuki&rft.aufirst=Koichi&rft.date=2006-05-01&rft.volume=189&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=00220795&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research. AN - 67890493; 16474168 AB - Clinical evidence reveals that the efficacy of dietary factors to prevent cancer is probably stage-dependent. The ability to demonstrate stage-specific effects of dietary compounds on normal, preneoplastic and malignant cell models may provide insights into puzzling clinical results from cancer chemoprevention trials. The relevance of these models to the field of cancer prevention is immense and will undoubtedly facilitate the ability to discover which dietary factors are most effective at preventing cancer and which, if any, specific steps in neoplastic transformation render cells refractory to the effects of dietary compounds. There are illustrative examples where exposure of high-risk individuals to dietary chemopreventive agents increases rather than decreases cancer risk. While geneticists and clinical oncologists acknowledge the morphological continuum along which tumors develop in specific tissues, tumor cells, rather than normal and preneoplastic cells, continue to be the primary in vitro reductionist tool employed to elucidate mechanisms underlying disease progression and to investigate the potential utility of dietary as well as other chemopreventive agents. Currently, there are few relevant model systems to study the progression of neoplastic transformation, especially in epithelial cells. We highlight examples of model systems isolated from prostate, breast, endometrial and intestinal tissue, with special emphasis on a specific set of non-tumorigenic, conditionally immortal cell lines derived from C57/BL6 mice [YAMC (Young Adult Mouse Colon cells; Apc+/+) cells and IMCE (Immorto-Min Colonic Epithelium cells; ApcMin/+) cells] that have yielded important information on early events in colorectal neoplasia development. These cell lines are an illustrative example of how researchers can examine stage-dependent effects of specific dietary components on carcinogenesis. The utilization of cell culture systems modeling early, middle and late stages of tumorigenesis will yield important insights into mechanisms by which dietary components impact cancer progression. JF - Carcinogenesis AU - Fenton, Jenifer I AU - Hord, Norman G AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7361, USA. imigjeni@msu.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 893 EP - 902 VL - 27 IS - 5 SN - 0143-3334, 0143-3334 KW - Anticarcinogenic Agents KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Humans KW - Mice, Inbred C57BL KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Genome KW - Cell Line KW - Anticarcinogenic Agents -- therapeutic use KW - Neoplasms -- prevention & control KW - Diet KW - Neoplasms -- diet therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67890493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Stage+matters%3A+choosing+relevant+model+systems+to+address+hypotheses+in+diet+and+cancer+chemoprevention+research.&rft.au=Fenton%2C+Jenifer+I%3BHord%2C+Norman+G&rft.aulast=Fenton&rft.aufirst=Jenifer&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-31 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional facets of the pulmonary neuroendocrine system. AN - 67876442; 16568108 AB - Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific literature, although phylogenetically they are ancient. Their traditionally ascribed functions include chemoreception and regulation of lung maturation and growth. There is recent evidence that neuroendocrine (NE) differentiation in the lung is regulated by genes and pathways that are conserved in the development of the nervous system from Drosophila to humans (such as achaete-scute homolog-1), or implicated in the carcinogenesis of the nervous or NE system (such as the retinoblastoma tumor suppressor gene). In addition, complex neural networks are in place to regulate chemosensory and other functions. Even solitary PNECs appear to be innervated. For the first time ever, we have mouse models for lung NE carcinomas, including the most common and virulent small cell lung carcinoma. Moreover, PNECs may be important for inflammatory responses, and pivotal for lung stem cell niches. These discoveries signify an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications. JF - Laboratory investigation; a journal of technical methods and pathology AU - Linnoila, R Ilona AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. linnoila@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 425 EP - 444 VL - 86 IS - 5 SN - 0023-6837, 0023-6837 KW - ASCL1 protein, human KW - 0 KW - Basic Helix-Loop-Helix Transcription Factors KW - Receptors, Notch KW - Index Medicus KW - Animals KW - Stem Cells -- cytology KW - Neoplasms -- pathology KW - Humans KW - Chemoreceptor Cells -- metabolism KW - Liver Diseases -- pathology KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Cell Differentiation KW - Stem Cells -- metabolism KW - Receptors, Notch -- metabolism KW - Signal Transduction KW - Neurosecretory Systems -- metabolism KW - Neurosecretory Systems -- embryology KW - Neurosecretory Systems -- cytology KW - Lung -- embryology KW - Neuroepithelial Bodies -- cytology KW - Neuroepithelial Bodies -- metabolism KW - Lung -- physiology KW - Lung -- innervation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67876442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Functional+facets+of+the+pulmonary+neuroendocrine+system.&rft.au=Linnoila%2C+R+Ilona&rft.aulast=Linnoila&rft.aufirst=R&rft.date=2006-05-01&rft.volume=86&rft.issue=5&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-27 N1 - Date created - 2006-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine causes alterations in the MAP kinase-related pathways in the brains of mice that display increased aggressiveness. AN - 67874876; 16192988 AB - Aggressive behaviors have been reported in patients who suffer from some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we report that multiple (but not single) injections of METH significantly increased aggressiveness in male CD-1 mice. This increase in aggressiveness was not secondary to METH-induced hyperactivity. Analysis of protein expression using antibody microarrays and Western blotting revealed differential changes in MAP kinase-related pathways after multiple and single METH injections. There were statistically significant (p<0.05) decreases in MEK1, Erk2p, GSK3alpha, 14-3-3e, and MEK7 in the striata of mice after multiple injections of METH. MEK1 was significantly decreased also after a single injection of METH, but to a much lesser degree than after multiple injections of METH. In the frontal cortex, there was a statistically significant decrease in GSK3alpha after multiple (but not single) injections of METH. These findings suggest that alterations in MAP kinase-related pathways in the prefronto-striatal circuitries might be involved in the manifestation of aggressive behaviors in mice. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Sokolov, Boris P AU - Cadet, Jean L AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA. Bsokolov@intra.nida.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 956 EP - 966 VL - 31 IS - 5 SN - 0893-133X, 0893-133X KW - Methamphetamine KW - 44RAL3456C KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - glycogen synthase kinase 3 alpha KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - Index Medicus KW - Frontal Lobe -- physiopathology KW - Animals KW - MAP Kinase Signaling System -- drug effects KW - MAP Kinase Signaling System -- physiology KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Frontal Lobe -- drug effects KW - Mental Disorders -- chemically induced KW - Disease Models, Animal KW - Motor Activity -- physiology KW - Mice KW - Phosphorylation -- drug effects KW - Mental Disorders -- physiopathology KW - Glycogen Synthase Kinase 3 -- drug effects KW - Frontal Lobe -- enzymology KW - Mental Disorders -- enzymology KW - Motor Activity -- drug effects KW - Glycogen Synthase Kinase 3 -- metabolism KW - MAP Kinase Kinase 1 -- drug effects KW - MAP Kinase Kinase 1 -- metabolism KW - Male KW - Brain -- physiopathology KW - Brain -- enzymology KW - Aggression -- drug effects KW - Methamphetamine -- adverse effects KW - Brain -- drug effects KW - Amphetamine-Related Disorders -- psychology KW - Amphetamine-Related Disorders -- enzymology KW - Aggression -- physiology KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67874876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Methamphetamine+causes+alterations+in+the+MAP+kinase-related+pathways+in+the+brains+of+mice+that+display+increased+aggressiveness.&rft.au=Sokolov%2C+Boris+P%3BCadet%2C+Jean+L&rft.aulast=Sokolov&rft.aufirst=Boris&rft.date=2006-05-01&rft.volume=31&rft.issue=5&rft.spage=956&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pendimethalin exposure and cancer incidence among pesticide applicators. AN - 67870934; 16452832 AB - Pendimethalin, a widely used herbicide, has been classified as a group C possible human carcinogen by the U.S. Environmental Protection Agency. We evaluated the incidence of cancer in relation to reported pendimethelin use among pesticide applicators in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Information on pesticide use came from two questionnaires (enrollment and take-home). The present analysis includes 9089 pendimethalin-exposed and 15,285 nonpendimethalin-exposed pesticide applicators with complete information on pendimethalin use and covariates from a take-home questionnaire. We conducted Poisson regression analyses to evaluate the association of pendimethalin exposure with cancer incidence (mean follow-up = 7.5 years) using two exposure metrics: tertiles of lifetime days of exposure and tertiles of intensity-weighted lifetime days of exposure. Overall cancer incidence did not increase with increasing lifetime pendimethalin use, and there was no clear evidence of an association between pendimethalin use and risks for specific cancers. The risk for rectal cancer rose with increasing lifetime pendimethalin exposure when using nonexposed as the reference (rate ratio = 4.3; 95% confidence interval = 1.5-12.7 for the highest exposed subjects; P for trend = 0.007), but the association was attenuated when using the low exposed as the referent group (P for trend = 0.08). Similar patterns for rectal cancer were observed when using intensity-weighted exposure-days. The number of rectal cancer cases among the pendimethalin-exposed was small (n = 19). There was some evidence for an elevated risk for lung cancer, but the excess occurred only in the highest exposure category for lifetime pendimethalin exposure. The trends for lung cancer risk were inconsistent for different exposure metrics. We did not find a clear association of lifetime pendimethalin exposure either with overall cancer incidence or with specific cancer sites. JF - Epidemiology (Cambridge, Mass.) AU - Hou, Lifang AU - Lee, Won Jin AU - Rusiecki, Jennifer AU - Hoppin, Jane A AU - Blair, Aaron AU - Bonner, Matthew R AU - Lubin, Jay H AU - Samanic, Claudine AU - Sandler, Dale P AU - Dosemeci, Mustafa AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 302 EP - 307 VL - 17 IS - 3 SN - 1044-3983, 1044-3983 KW - Aniline Compounds KW - 0 KW - pendimethalin KW - VL6L14C06U KW - Index Medicus KW - Prospective Studies KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Aniline Compounds -- poisoning KW - Environmental Exposure -- analysis KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67870934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Pendimethalin+exposure+and+cancer+incidence+among+pesticide+applicators.&rft.au=Hou%2C+Lifang%3BLee%2C+Won+Jin%3BRusiecki%2C+Jennifer%3BHoppin%2C+Jane+A%3BBlair%2C+Aaron%3BBonner%2C+Matthew+R%3BLubin%2C+Jay+H%3BSamanic%2C+Claudine%3BSandler%2C+Dale+P%3BDosemeci%2C+Mustafa%3BAlavanja%2C+Michael+C+R&rft.aulast=Hou&rft.aufirst=Lifang&rft.date=2006-05-01&rft.volume=17&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-31 N1 - Date created - 2006-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Agric Food Chem. 2001 May;49(5):2198-206 [11368577] Br J Cancer. 1985 Aug;52(2):259-70 [4027168] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Int J Cancer. 2004 Jan 20;108(3):433-42 [14648711] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] IARC Sci Publ. 1980;(32):5-338 [7216345] Environ Res. 1999 Feb;80(2 Pt 1):180-6 [10092411] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Int J Epidemiol. 1996 Dec;25(6):1117-24 [9027514] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Bull Environ Contam Toxicol. 1994 Apr;52(4):498-504 [8167442] Scand J Work Environ Health. 1993 Dec;19(6):382-9 [8153589] Cancer. 1993 Nov 1;72(9):2543-9 [8402474] Scand J Work Environ Health. 1992 Jun;18(3):201-4 [1615295] Lancet. 1991 Oct 26;338(8774):1027-32 [1681353] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Br J Ind Med. 1988 Feb;45(2):98-105 [3342201] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma. AN - 67865389; 16618582 AB - To perform an analysis of three-dimensional conformal radiation therapy (3D-CRT), sequential boost intensity-modulated radiation therapy (IMRTs), and integrated boost IMRT (IMRTi) for dose escalation in unresectable pancreatic carcinoma. Computed tomography images from 15 patients were used. Treatment plans were generated using 3D-CRT, IMRTs, and IMRTi for dose levels of 54, 59.4, and 64.8 Gy. Plans were analyzed for target coverage, doses to liver, kidneys, small bowel, and spinal cord. Three-dimensional-CRT exceeded tolerance to small bowel in 1 of 15 (6.67%) patients at 54 Gy, and 4 of 15 (26.7%) patients at 59.4 and 64.8 Gy. 3D-CRT exceeded spinal cord tolerance in 1 of 15 patients (6.67%) at 59.4 Gy and liver constraints in 1 of 15 patients (6.67%) at 64.8 Gy; no IMRT plans exceeded tissue tolerance. Both IMRT techniques reduced the percentage of total kidney volume receiving 20 Gy (V20), the percentage of small bowel receiving 45 Gy (V45), and the percentage of liver receiving 35 Gy (V35). IMRTi appeared superior to IMRTs in reducing the total kidney V20 (p < 0.0001), right kidney V20 (p < 0.0001), and small bowel V45 (p = 0.02). Sequential boost IMRT and IMRTi improved the ability to achieve normal tissue dose goals compared with 3D-CRT. IMRTi allowed dose escalation to 64.8 Gy with acceptable normal tissue doses and superior dosimetry compared with 3D-CRT and IMRTs. JF - International journal of radiation oncology, biology, physics AU - Brown, Michael W AU - Ning, Holly AU - Arora, Barbara AU - Albert, Paul S AU - Poggi, Matthew AU - Camphausen, Kevin AU - Citrin, Deborah AD - Radiation Oncology Branch, CCR, National Institutes of Health, Bethesda, MD 20892-1002, USA. Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 274 EP - 283 VL - 65 IS - 1 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Kidney -- radiation effects KW - Spinal Cord -- radiation effects KW - Feasibility Studies KW - Radiotherapy, Conformal -- methods KW - Radiotherapy Dosage KW - Humans KW - Radiography KW - Maximum Tolerated Dose KW - Dose-Response Relationship, Radiation KW - Liver -- radiation effects KW - Intestine, Small -- radiation effects KW - Carcinoma -- diagnostic imaging KW - Pancreatic Neoplasms -- radiotherapy KW - Radiotherapy, Intensity-Modulated -- methods KW - Radiation Injuries -- prevention & control KW - Carcinoma -- radiotherapy KW - Pancreatic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67865389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=A+dosimetric+analysis+of+dose+escalation+using+two+intensity-modulated+radiation+therapy+techniques+in+locally+advanced+pancreatic+carcinoma.&rft.au=Brown%2C+Michael+W%3BNing%2C+Holly%3BArora%2C+Barbara%3BAlbert%2C+Paul+S%3BPoggi%2C+Matthew%3BCamphausen%2C+Kevin%3BCitrin%2C+Deborah&rft.aulast=Brown&rft.aufirst=Michael&rft.date=2006-05-01&rft.volume=65&rft.issue=1&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vesicle depletion and synaptic depression at a mammalian ribbon synapse. AN - 67862491; 16452253 AB - We estimated the size of the readily releasable pool (RRP) of vesicles at a ribbon synapse in the rat retina by making paired voltage-clamp recordings from presynaptic rod bipolar cells (RBCs) and postsynaptic AII amacrine cells in an in vitro retinal slice preparation. The RRP at each active zone was estimated to constitute seven vesicles, in the range of estimated RRP sizes at conventional synapses. During sustained presynaptic Ca(2+) entry, the RRP could be released with a time constant of about 4 ms. This ribbon synapse exhibited pronounced paired-pulse depression (PPD), which was attributable primarily to vesicle depletion. Recovery from PPD was slow (tau approximately 4 s) but could be accelerated by increasing the duration of the depressing stimulus. The small RRP and very high release probability likely contribute to the transient characteristics of neurotransmission at RBC synapses. JF - Journal of neurophysiology AU - Singer, Joshua H AU - Diamond, Jeffrey S AD - Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. j-singer@northwestern.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3191 EP - 3198 VL - 95 IS - 5 SN - 0022-3077, 0022-3077 KW - Benzothiadiazines KW - 0 KW - cyclothiazide KW - P71U09G5BW KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Retinal Bipolar Cells -- radiation effects KW - Benzothiadiazines -- pharmacology KW - Retinal Bipolar Cells -- physiology KW - Dose-Response Relationship, Radiation KW - Rats KW - Calcium -- metabolism KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Amacrine Cells -- physiology KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Amacrine Cells -- radiation effects KW - Time Factors KW - Excitatory Postsynaptic Potentials -- physiology KW - Retina -- cytology KW - Synapses -- physiology KW - Neural Inhibition -- radiation effects KW - Synaptic Vesicles -- metabolism KW - Synapses -- radiation effects KW - Neural Inhibition -- drug effects KW - Neural Inhibition -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67862491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Vesicle+depletion+and+synaptic+depression+at+a+mammalian+ribbon+synapse.&rft.au=Singer%2C+Joshua+H%3BDiamond%2C+Jeffrey+S&rft.aulast=Singer&rft.aufirst=Joshua&rft.date=2006-05-01&rft.volume=95&rft.issue=5&rft.spage=3191&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-28 N1 - Date created - 2006-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibody-based inhibitors of HIV infection. AN - 67858591; 16610981 AB - The demand for new treatment options against HIV is becoming increasingly desperate as the side effects and the expansion and spread of drug-resistant virus within the infected population limit the clinical benefits provided by available anti-HIV drugs. Preparations of polyclonal antibodies have a long history of proven clinical utility against some viruses; however, they have enjoyed very limited success against HIV. Recent clinical trials and in vitro experiments suggest that monoclonal antibodies against HIV may have promise clinically. These antibodies and antibody-based reagents target either the viral envelope glycoprotein, the receptor (CD4) or coreceptor (CCR5) molecules, or transition-state structures that appear during viral entry. The challenge is whether an antibody-based therapy can be identified (with or without their small molecule brethren) that presents long-term clinical efficacy, low toxicity and minimal risk of clinical failure from viral resistance. JF - Expert opinion on biological therapy AU - Choudhry, Vidita AU - Zhang, Mei-Yun AU - Dimitrova, Dimana AU - Prabakaran, Ponraj AU - Dimitrov, Antony S AU - Fouts, Timothy R AU - Dimitrov, Dimiter S AD - NCI-Frederick, Protein Interactions Group, CCRNP, CCR, NIH, P.O. Box B, Frederick, MD 21702-1201, USA. vchoudhry@ncifcrf.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 523 EP - 531 VL - 6 IS - 5 KW - Antigens, CD4 KW - 0 KW - HIV Antibodies KW - HIV Envelope Protein gp120 KW - HIV Envelope Protein gp41 KW - Receptors, CCR5 KW - Index Medicus KW - Animals KW - HIV Envelope Protein gp120 -- immunology KW - Humans KW - Antigens, CD4 -- genetics KW - Clinical Trials as Topic KW - HIV Envelope Protein gp41 -- immunology KW - Receptors, CCR5 -- immunology KW - Antigens, CD4 -- immunology KW - HIV-1 -- immunology KW - HIV Antibodies -- immunology KW - HIV Infections -- therapy KW - HIV Antibodies -- therapeutic use KW - Immunotherapy -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67858591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Antibody-based+inhibitors+of+HIV+infection.&rft.au=Choudhry%2C+Vidita%3BZhang%2C+Mei-Yun%3BDimitrova%2C+Dimana%3BPrabakaran%2C+Ponraj%3BDimitrov%2C+Antony+S%3BFouts%2C+Timothy+R%3BDimitrov%2C+Dimiter+S&rft.aulast=Choudhry&rft.aufirst=Vidita&rft.date=2006-05-01&rft.volume=6&rft.issue=5&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychosis among substance users. AN - 67857713; 16612208 AB - This work reviews the evidence that substances of abuse can cause psychosis in nonpsychotic persons. The review is based on the concept that psychosis exists in continuum. Studies examining substance use in, or its effect on, already psychotic individuals were not reviewed. A substantial proportion of substance users experience psychosis. Use of cocaine, amphetamines, cannabis and alcohol seems to be associated with greater risk for psychosis. Severity and duration of use, age at the time of first use and vulnerability to develop psychosis by virtue of familial, possibly genetic and personality factors seem to be the determinants for the development of psychosis. Epidemiological and preliminary biological studies suggest that cannabis is a component cause in the development of schizophrenia. Evidence for the causative role of other substances is less systematic. There exists strong evidence that abuse of substances is associated with greater risk for psychosis and preliminary evidence for their causative role in the development of psychosis. More systematic examination of this issue is likely to throw light on the neurobiology of psychosis and possibly help the vulnerable population in primary prevention. JF - Current opinion in psychiatry AU - Thirthalli, Jagadisha AU - Benegal, Vivek AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India. jaga@nimhans.kar.nic.in Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 239 EP - 245 VL - 19 IS - 3 SN - 0951-7367, 0951-7367 KW - Index Medicus KW - Humans KW - Adult KW - Adolescent KW - Psychoses, Substance-Induced -- psychology KW - Psychoses, Substance-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67857713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+psychiatry&rft.atitle=Psychosis+among+substance+users.&rft.au=Thirthalli%2C+Jagadisha%3BBenegal%2C+Vivek&rft.aulast=Thirthalli&rft.aufirst=Jagadisha&rft.date=2006-05-01&rft.volume=19&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+psychiatry&rft.issn=09517367&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-03 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses. AN - 67843449; 16485136 AB - The double-strand break DNA repair pathway has been implicated in breast carcinogenesis. We evaluated the association between 19 polymorphisms in seven genes in this pathway (XRCC2, XRCC3, BRCA2, ZNF350, BRIP1, XRCC4, LIG4) and breast cancer risk in two population-based studies in USA (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls). These data suggested weak associations with breast cancer risk for XRCC3 T241M and IVS7-14A>G (pooled odds ratio (95% confidence interval): 1.18 (1.04-1.34) and 0.85 (0.73-0.98) for homozygous variant vs wild-type genotypes, respectively), and for an uncommon variant in ZNF350 S472P (1.24 (1.05-1.48)), with no evidence for study heterogeneity. The remaining variants examined had no significant relationships to breast cancer risk. Meta-analyses of studies in Caucasian populations, including ours, provided some support for a weak association for homozygous variants for XRCC3 T241M (1.16 (1.04-1.30); total of 10,979 cases and 10,423 controls) and BRCA2 N372H (1.13 (1.10-1.28); total of 13,032 cases and 13,314 controls), and no support for XRCC2 R188H (1.06 (0.59-1.91); total of 8,394 cases and 8,404 controls). In conclusion, the genetic variants evaluated are unlikely to have a substantial overall association with breast cancer risk; however, weak associations are possible for XRCC3 (T241M and IVS7-14A>G), BRCA2 N372H, and ZNF350 S472P. Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes. JF - Human genetics AU - García-Closas, Montserrat AU - Egan, Kathleen M AU - Newcomb, Polly A AU - Brinton, Louise A AU - Titus-Ernstoff, Linda AU - Chanock, Stephen AU - Welch, Robert AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Bardin-Mikolajczak, Alicja AU - Struewing, Jeffery P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952-7234, USA. montse@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 376 EP - 388 VL - 119 IS - 4 SN - 0340-6717, 0340-6717 KW - Cell Cycle Proteins KW - 0 KW - DNA, Neoplasm KW - DNA-Binding Proteins KW - Index Medicus KW - United States KW - Humans KW - DNA-Binding Proteins -- genetics KW - Aged KW - Genotype KW - Cell Cycle Proteins -- genetics KW - Poland KW - Adult KW - Case-Control Studies KW - Genes, Tumor Suppressor -- physiology KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Polymorphism, Genetic KW - DNA, Neoplasm -- genetics KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67843449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genetics&rft.atitle=Polymorphisms+in+DNA+double-strand+break+repair+genes+and+risk+of+breast+cancer%3A+two+population-based+studies+in+USA+and+Poland%2C+and+meta-analyses.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BEgan%2C+Kathleen+M%3BNewcomb%2C+Polly+A%3BBrinton%2C+Louise+A%3BTitus-Ernstoff%2C+Linda%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BBardin-Mikolajczak%2C+Alicja%3BStruewing%2C+Jeffery+P&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2006-05-01&rft.volume=119&rft.issue=4&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Human+genetics&rft.issn=03406717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diet and body mass, and oral and oropharyngeal squamous cell carcinomas: analysis from the IARC multinational case-control study. AN - 67696829; 16331628 AB - Tobacco and alcohol use are the main risk factors for oral and oropharyngeal cancers, yet, dietary habits may also be of importance. Data from a series of case-control studies conducted in 9 countries worldwide (1,670 cases and 1,732 controls) were used to investigate the role of several food groups and body mass index (BMI). Low BMI significantly increased the odds ratio (OR) of cancer more than 2-fold among ever- and never-tobacco users and ever- and never-alcohol drinkers. After adjustment for potential confounders, high intake of fruits and vegetables significantly reduced the OR of cancer compared to low intake among ever-tobacco users (OR 0.4, 95% confidence interval [CI] 0.3-0.6), although not among never-tobacco users (OR 1.1, 95% CI 0.6-2.0). Similarly, the protective effect of high fruit and vegetable consumption was present among ever-drinkers (OR 0.4, 95% CI 0.3-0.6), but not among never-drinkers (OR 1.0, 95% CI 0.6-1.6). In conclusion, low BMI increases the risk of oral cancer, and vegetables and fruits may modulate the carcinogenic effects of tobacco and alcohol. 2005 Wiley-Liss, Inc. JF - International journal of cancer AU - Kreimer, Aimée R AU - Randi, Giorgia AU - Herrero, Rolando AU - Castellsagué, Xavier AU - La Vecchia, Carlo AU - Franceschi, Silvia AU - IARC Multicenter Oral Cancer Study Group AD - Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; IARC Multicenter Oral Cancer Study Group Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 2293 EP - 2297 VL - 118 IS - 9 SN - 0020-7136, 0020-7136 KW - Index Medicus KW - Vegetables KW - Humans KW - Case-Control Studies KW - Alcohol Drinking -- adverse effects KW - Smoking -- adverse effects KW - Fruit KW - Oropharyngeal Neoplasms -- prevention & control KW - Mouth Neoplasms -- prevention & control KW - Mouth Neoplasms -- etiology KW - Oropharyngeal Neoplasms -- epidemiology KW - Oropharyngeal Neoplasms -- etiology KW - Diet KW - Body Mass Index KW - Mouth Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67696829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Diet+and+body+mass%2C+and+oral+and+oropharyngeal+squamous+cell+carcinomas%3A+analysis+from+the+IARC+multinational+case-control+study.&rft.au=Kreimer%2C+Aim%C3%A9e+R%3BRandi%2C+Giorgia%3BHerrero%2C+Rolando%3BCastellsagu%C3%A9%2C+Xavier%3BLa+Vecchia%2C+Carlo%3BFranceschi%2C+Silvia%3BIARC+Multicenter+Oral+Cancer+Study+Group&rft.aulast=Kreimer&rft.aufirst=Aim%C3%A9e&rft.date=2006-05-01&rft.volume=118&rft.issue=9&rft.spage=2293&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT. AN - 67657061; 16440292 AB - [(18)F]FCWAY and [(18)F]FPWAY, analogues of the high affinity 5-HT(1A) receptor (5-HT(1A)R) antagonist WAY100635, were evaluated in rodents as potential radiopharmaceuticals for determining 5-HT(1A)R density and changes in receptor occupancy due to changes in endogenous serotonin (5-HT) levels. The in vivo hippocampus specific binding ratio [(hippocampus(uptake)/cerebellum(uptake))-1] of [(18)F]FPWAY was decreased to 32% of the ratio of [(18)F]FCWAY, indicating that [(18)F]FPWAY has lower affinity than [(18)F]FCWAY. The 5-HT(1A)R selectivity of [(18)F]FPWAY was confirmed using ex vivo autoradiography studies with 5-HT(1A)R knockout, heterozygous, and wildtype mice.Pre- or post-treatment of awake rodents in tissue dissection studies with paroxetine had no effect on hippocampal binding of [(18)F]FCWAY or [(18)F]FPWAY compared to controls, indicating neither tracer was sensitive to changes in endogenous 5-HT. In mouse ex vivo autoradiography studies in which awake mice were treated with fenfluramine following the [(18)F]FPWAY, a significant decrease was not observed in the hippocampus specific binding ratios. In rat dissection studies with fenfluramine administered following [(18)F]FPWAY or [(18)F]FBWAY ([(18)F]-MPPF) in awake or urethane-anesthetized rats, no significant differences in the specific binding ratios of the hippocampus were observed compared to their respective controls. [(18)F]FPWAY and [(18)F]FBWAY uptakes in all brain regions were increased variably in the anesthetized group (with the greatest increase in the hippocampus) vs. the awake group, but were decreased in the fenfluramine-treated anesthetized group vs. the anesthetized group. These data are best explained by changes in blood flow caused by urethane and fenfluramine, which varies from region to region in the brain. JF - Synapse (New York, N.Y.) AU - Jagoda, Elaine M AU - Lang, Lixin AU - Tokugawa, Joji AU - Simmons, Ashlie AU - Ma, Ying AU - Contoreggi, Carlo AU - Kiesewetter, Dale AU - Eckelman, William C AD - Positron Emission Tomography PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. ejagoda@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 330 EP - 341 VL - 59 IS - 6 SN - 0887-4476, 0887-4476 KW - Cyclohexanes KW - 0 KW - Fluorine Radioisotopes KW - Ligands KW - N-(2-(4-(2-methoxyphenyl)piperazino))-N-(2-pyridinyl) trans-4-fluorocyclohexanecarboxamide KW - Piperazines KW - Pyridines KW - Serotonin Antagonists KW - Receptor, Serotonin, 5-HT1A KW - 112692-38-3 KW - Serotonin KW - 333DO1RDJY KW - N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide KW - 71IH826FEG KW - Index Medicus KW - Animals KW - Pyridines -- chemistry KW - Drug Interactions KW - Fluorine Radioisotopes -- pharmacokinetics KW - Piperazines -- chemistry KW - Serotonin Antagonists -- pharmacology KW - Brain Chemistry -- drug effects KW - Mice KW - Serotonin Antagonists -- chemistry KW - Piperazines -- pharmacology KW - Mice, Knockout KW - Rats KW - Piperazines -- pharmacokinetics KW - Rats, Sprague-Dawley KW - Tissue Distribution -- drug effects KW - Autoradiography -- methods KW - Time Factors KW - Pyridines -- pharmacology KW - Cyclohexanes -- pharmacokinetics KW - Male KW - Brain Chemistry -- physiology KW - Receptor, Serotonin, 5-HT1A -- analysis KW - Brain -- drug effects KW - Brain -- metabolism KW - Receptor, Serotonin, 5-HT1A -- deficiency KW - Radioligand Assay KW - Serotonin -- metabolism KW - Receptor, Serotonin, 5-HT1A -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Development+of+5-HT1A+receptor+radioligands+to+determine+receptor+density+and+changes+in+endogenous+5-HT.&rft.au=Jagoda%2C+Elaine+M%3BLang%2C+Lixin%3BTokugawa%2C+Joji%3BSimmons%2C+Ashlie%3BMa%2C+Ying%3BContoreggi%2C+Carlo%3BKiesewetter%2C+Dale%3BEckelman%2C+William+C&rft.aulast=Jagoda&rft.aufirst=Elaine&rft.date=2006-05-01&rft.volume=59&rft.issue=6&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-28 N1 - Date created - 2006-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The pharmacokinetics of rituximab following an intravitreal injection. AN - 67629453; 16289160 AB - Rituximab is a monoclonal antibody directed against the CD20 B-cell antigen and is approved for the treatment of B-cell lymphoma. We investigated the pharmacokinetics of rituximab following intravitreal administration to assess the feasibility of treating primary intraocular lymphoma. Intravitreal injections of rituximab 0.1 ml (1 mg) were performed in rabbits. Drug concentrations in the aqueous and vitreous humor were measured at intervals from 2 to 17 days after administration. The half-life of the total amount of rituximab in the two compartments was calculated to be 4.7 days. The aqueous and vitreous humor drug levels decayed in parallel maintaining an average ratio of approximately seven. Fitting the data to a two-compartment model yielded a clearance from the aqueous humor of 1.2 microl/min. The clearance was less than the reported rate of aqueous humor outflow indicating that elimination by this route could have been sufficient to account for the disappearance of the drug from the eye. The duration of time over which sustained levels of rituximab were achieved suggest that intravitreal administration warrants further investigation as an approach to treating vitreous and anterior chamber infiltrates in patients with primary intraocular lymphoma. JF - Experimental eye research AU - Kim, Hyuncheol AU - Csaky, Karl G AU - Chan, Chi-Chao AU - Bungay, Peter M AU - Lutz, Robert J AU - Dedrick, Robert L AU - Yuan, Peng AU - Rosenberg, Jay AU - Grillo-Lopez, Antonio J AU - Wilson, Wyndham H AU - Robinson, Michael R AD - National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1863, USA. Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 760 EP - 766 VL - 82 IS - 5 SN - 0014-4835, 0014-4835 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Antineoplastic Agents KW - Rituximab KW - 4F4X42SYQ6 KW - Index Medicus KW - Animals KW - Feasibility Studies KW - Half-Life KW - Rabbits KW - Eye Neoplasms -- metabolism KW - Injections KW - Models, Biological KW - Male KW - Lymphoma, B-Cell -- metabolism KW - Female KW - Aqueous Humor -- metabolism KW - Antibodies, Monoclonal -- toxicity KW - Vitreous Body -- metabolism KW - Antibodies, Monoclonal -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67629453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=The+pharmacokinetics+of+rituximab+following+an+intravitreal+injection.&rft.au=Kim%2C+Hyuncheol%3BCsaky%2C+Karl+G%3BChan%2C+Chi-Chao%3BBungay%2C+Peter+M%3BLutz%2C+Robert+J%3BDedrick%2C+Robert+L%3BYuan%2C+Peng%3BRosenberg%2C+Jay%3BGrillo-Lopez%2C+Antonio+J%3BWilson%2C+Wyndham+H%3BRobinson%2C+Michael+R&rft.aulast=Kim&rft.aufirst=Hyuncheol&rft.date=2006-05-01&rft.volume=82&rft.issue=5&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=00144835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostate cancer epidemiology. AN - 67584732; 16368524 AB - Prostate cancer is the most common non-skin cancer among men in most western populations, and it is the second leading cause of cancer death among U.S. men. Despite its high morbidity, the etiology of prostate cancer remains largely unknown. Advancing age, race, and a family history of prostate cancer are the only established risk factors. Many putative risk factors, including androgens, diet, physical activity, sexual factors, inflammation, and obesity, have been implicated, but their roles in prostate cancer etiology remain unclear. It is estimated that as much as 42% of the risk of prostate cancer may be accounted for by genetic influences, including individual and combined effects of rare, highly penetrant genes, more common weakly penetrant genes, and genes acting in concert with each other. Numerous genetic variants in the androgen biosynthesis/metabolism, carcinogen metabolism, DNA repair, and chronic inflammation pathways, have been explored, but the results are largely inconclusive. The pathogenesis of prostate cancer likely involves interplay between environmental and genetic factors. To unravel these complex relationships, large well-designed interdisciplinary epidemiologic studies are needed. With newly available molecular tools, a new generation of large-scale multidisciplinary population-based studies is beginning to investigate gene-gene and gene-environment interactions. Results of these studies may lead to better detection, treatment, and, ultimately, prevention of prostate cancer. JF - Frontiers in bioscience : a journal and virtual library AU - Hsing, Ann W AU - Chokkalingam, Anand P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852-7234, USA. hsinga@mail.nih.gov Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 1388 EP - 1413 VL - 11 SN - 1093-9946, 1093-9946 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Receptors, Androgen KW - Index Medicus KW - Genetic Variation KW - DNA Repair KW - Polymorphism, Genetic KW - Humans KW - Models, Biological KW - Inflammation KW - Prostatic Hyperplasia KW - Epidemiology KW - Obesity -- genetics KW - Risk Factors KW - Carcinogens -- chemistry KW - Incidence KW - Neovascularization, Pathologic KW - Receptors, Androgen -- chemistry KW - Male KW - Prostatic Neoplasms -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- epidemiology KW - Prostate -- metabolism KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67584732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Prostate+cancer+epidemiology.&rft.au=Hsing%2C+Ann+W%3BChokkalingam%2C+Anand+P&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2006-05-01&rft.volume=11&rft.issue=&rft.spage=1388&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-02 N1 - Date created - 2005-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adaptive and Maladaptive Behavior in Children with Smith-Magenis Syndrome AN - 57110211; 200706681 AB - Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires & the Childhood Autism Rating Scale. Cognitive functioning was evaluated with an age-appropriate test. Children scored below average on VABS Communication, Daily Living Skills, & Socialization scales. Learning problems & hyperactivity scales on the Conner's Parent Rating Scale were elevated, & girls were more impulsive than boys. Stereotypic & self-injurious behaviors were present in all children. Cognitive functioning was delayed & consistent with communication & daily living skills, while socialization scores were higher than IQ. Tables, Figures, References. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Martin, Staci C AU - Wolters, Pamela L AU - Smith, Ann C M AD - National Cancer Instit, Bethesda, MD martins@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 541 EP - 552 PB - Springer, Dordrecht The Netherlands VL - 36 IS - 4 SN - 0162-3257, 0162-3257 KW - Smith-Magenis syndrome KW - adaptive functioning KW - social skills KW - IQ KW - Functioning KW - Social skills KW - Adaptation KW - Behavioural problems KW - Children KW - Intelligence quotient KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Adaptive+and+Maladaptive+Behavior+in+Children+with+Smith-Magenis+Syndrome&rft.au=Martin%2C+Staci+C%3BWolters%2C+Pamela+L%3BSmith%2C+Ann+C+M&rft.aulast=Martin&rft.aufirst=Staci&rft.date=2006-05-01&rft.volume=36&rft.issue=4&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-006-0093-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Intelligence quotient; Social skills; Functioning; Adaptation; Children; Behavioural problems DO - http://dx.doi.org/10.1007/s10803-006-0093-2 ER - TY - CPAPER T1 - Cellular and Tissue Distribution of Globotriaosylceramide in Fabry Disease T2 - 2006 Annual Scientific Meeting of the Australian Association of Neurologists AN - 39994021; 4212075 JF - 2006 Annual Scientific Meeting of the Australian Association of Neurologists AU - Askari, Hasan Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 KW - Globotriaosylceramide KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Scientific+Meeting+of+the+Australian+Association+of+Neurologists&rft.atitle=Cellular+and+Tissue+Distribution+of+Globotriaosylceramide+in+Fabry+Disease&rft.au=Askari%2C+Hasan&rft.aulast=Askari&rft.aufirst=Hasan&rft.date=2006-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Scientific+Meeting+of+the+Australian+Association+of+Neurologists&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/aan2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Maternal psychological distress during pregnancy in relation to child development at age two AN - 37747252; 3278205 AB - Concern exists that a constellation of negative maternal emotions during pregnancy generates persistent negative consequences for child development. Maternal reports of anxiety, pregnancy-specific and nonspecific stress, and depressive symptoms, were collected during mid-pregnancy and at 6 weeks and 24 months after birth in a sample of health women with low risk pregnancies. Developmental assessment and cardiac vagal tone monitoring were administered to 94 children at age 2. Higher levels of prenatal anxiety, nonspecific stress, and depressive symptoms were associated with more advanced motor development in children after postnatal control for each psychological measure; anxiety and depression were also significant and positively associated with mental development. Mild to moderate levels of psychological distress may enhance fetal maturation in healthy populations. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - DiPietro, Janet A AU - Novak, Matthew F.S.X. AU - Costigan, Kathleen A AU - Atella, Lara D AU - Reusing, Sarah P AD - Johns Hopkins University ; National Institute of Child Health and Human Development Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 573 EP - 587 VL - 77 IS - 3 SN - 0009-3920, 0009-3920 KW - Sociology KW - Birth KW - Anxiety KW - Mental stress KW - Factor analysis KW - Mothers KW - Health KW - Child development KW - Developmental psychology KW - Psychological effects KW - Family studies KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37747252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Maternal+psychological+distress+during+pregnancy+in+relation+to+child+development+at+age+two&rft.au=DiPietro%2C+Janet+A%3BNovak%2C+Matthew+F.S.X.%3BCostigan%2C+Kathleen+A%3BAtella%2C+Lara+D%3BReusing%2C+Sarah+P&rft.aulast=DiPietro&rft.aufirst=Janet&rft.date=2006-05-01&rft.volume=77&rft.issue=3&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8317 9184; 7953 7954; 10399 4109 2088 10642 2688 2449 10404; 10020; 3518 10404; 2197 2212 6075 3483; 1147 4196; 1635 11574; 5772; 4722 12224 971; 4783 ER - TY - JOUR T1 - Recruiting teen smokers in shopping malls to a smoking-cessation program using the foot-in-the-door technique AN - 37727708; 3268402 JF - Journal of applied social psychology AU - Bloom, Paul N AU - McBride, Colleen M AU - Pollak, Kathryn I AU - Schwartz-Bloom, Rochelle D AU - Lipkus, Isaac M AD - University of North Carolina ; National Human Genome Research Institute ; Duke University Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1129 EP - 1144 VL - 36 IS - 5 SN - 0021-9029, 0021-9029 KW - Sociology KW - Smoking KW - Social psychology KW - Interviews KW - Data analysis KW - Sociometric tests KW - Psychological effects KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37727708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+social+psychology&rft.atitle=Recruiting+teen+smokers+in+shopping+malls+to+a+smoking-cessation+program+using+the+foot-in-the-door+technique&rft.au=Bloom%2C+Paul+N%3BMcBride%2C+Colleen+M%3BPollak%2C+Kathryn+I%3BSchwartz-Bloom%2C+Rochelle+D%3BLipkus%2C+Isaac+M&rft.aulast=Bloom&rft.aufirst=Paul&rft.date=2006-05-01&rft.volume=36&rft.issue=5&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+social+psychology&rft.issn=00219029&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11755 5707 6071 1542 11325; 593; 12039 12040 10414; 3279 971 3286; 6832 10919; 10399 4109 2088 10642 2688 2449 10404; 11901 10404 ER - TY - JOUR T1 - Phased array ghost elimination AN - 21063155; 8632139 AB - Parallel imaging may be applied to cancel ghosts caused by a variety of distortion mechanisms, including distortions such as off-resonance or local flow, which are space variant. Phased array combining coefficients may be calculated that null ghost artifacts at known locations based on a constrained optimization, which optimizes SNR subject to the nulling constraint. The resultant phased array ghost elimination (PAGE) technique is similar to the method known as sensitivity encoding (SENSE) used for accelerated imaging; however, in this formulation is applied to full field-of-view (FOV) images. The phased array method for ghost elimination may result in greater flexibility in designing acquisition strategies. For example, in multi-shot EPI applications ghosts are typically mitigated by the use of an interleaved phase encode acquisition order. An alternative strategy is to use a sequential, non-interleaved phase encode order and cancel the resultant ghosts using PAGE parallel imaging. Cancellation of ghosts by means of phased array processing makes sequential, non-interleaved phase encode acquisition order practical, and permits a reduction in repetition time, TR, by eliminating the need for echo-shifting. Sequential, non-interleaved phase encode order has benefits of reduced distortion due to off-resonance, in-plane flow and EPI delay misalignment. Furthermore, the use of EPI with PAGE has inherent fat-water separation and has been used to provide off-resonance correction using a technique referred to as lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA), and may further generalized using the multi-point Dixon method. Other applications of PAGE include cancelling ghosts which arise due to amplitude or phase variation during the approach to steady state. Parallel imaging requires estimates of the complex coil sensitivities. In vivo estimates may be derived by temporally varying the phase encode ordering to obtain a full k-space dataset in a scheme similar to the autocalibrating TSENSE method. This scheme is a generalization of the UNFOLD method used for removing aliasing in undersampled acquisitions. The more general scheme may be used to modulate each EPI ghost image to a separate temporal frequency as described in this paper. JF - NMR in Biomedicine AU - Kellman, Peter AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, MD 20892-1061, USA, kellman@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 352 EP - 361 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 19 IS - 3 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Phase variations KW - Lipids KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Phased+array+ghost+elimination&rft.au=Kellman%2C+Peter%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2006-05-01&rft.volume=19&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Repetition; N.M.R.; Lipids; Phase variations DO - http://dx.doi.org/10.1002/nbm.1044 ER - TY - JOUR T1 - Accelerated parallel imaging for functional imaging of the human brain AN - 21063078; 8632138 AB - Accelerated parallel imaging (PI) techniques have recently been applied to functional imaging experiments of the human brain in order to improve the performance of commonly used single-shot techniques like echo-planar imaging (EPI). Potential benefits of PI-fMRI include the reduction of geometrical distortions due to off-resonance signals, the reduction of signal-loss in areas with substantial signal inhomogeneity, increases of the spatial and temporal resolution of the fMRI experiment and reduction of gradient acoustic noise. Although PI generally leads to a substantial decrease in image signal-to-noise ratio (SNR), its effect on the temporal stability of the signal, which ultimately determines fMRI performance, is only partially determined by image SNR. Therefore, the penalty for using PI is generally not as severe as the SNR reduction. The majority of problems related to single-shot techniques become more severe at an increased magnetic field strength, making PI an important tool in achieving the full potential of fMRI at high field. JF - NMR in Biomedicine AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Golay, Xavier AU - Ikonomidou, Vasiliki N AU - Duyn, Jeff H AD - Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, Maryland, USA, Jacco.deZwart@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 342 EP - 351 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 19 IS - 3 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Neuroimaging KW - Acoustics KW - Functional magnetic resonance imaging KW - Magnetic fields KW - N.M.R. KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Accelerated+parallel+imaging+for+functional+imaging+of+the+human+brain&rft.au=de+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BGolay%2C+Xavier%3BIkonomidou%2C+Vasiliki+N%3BDuyn%2C+Jeff+H&rft.aulast=de+Zwart&rft.aufirst=Jacco&rft.date=2006-05-01&rft.volume=19&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Functional magnetic resonance imaging; Brain mapping; Acoustics; N.M.R.; Magnetic fields DO - http://dx.doi.org/10.1002/nbm.1043 ER - TY - JOUR T1 - Plasma proteomic profiling: Search for lung cancer diagnostic and early detection markers AN - 20862475; 9360938 AB - Environmental and occupational exposure to asbestos is among the established risk factors for lung cancer, the leading cause of cancer-related deaths in the United States. This link between exposure to asbestos and the excessive death rate from lung cancer was evident in a study of former workers of an asbestos pipe insulation manufacturing plant in Tyler, TX. We performed comparative proteomic profiling of plasma samples that were collected from nine patients within 12 months before death and their age-, race- and exposure-matched disease-free controls on strong anion exchange chips using surface-enhanced laser desorption ionization time-of-flight mass spectrometry. A distance-dependent K-nearest neighbor (KNN) classification algorithm identified spectral features of m/z values 7558.9 and 15103.0 that were able to distinguish lung cancer patients from disease-free individuals with high sensitivity and specificity. The high correlation between the intensities of these two peaks (r=0.987) strongly suggests that they are the doubly and singly charged ions of the same protein product. Examination of these proteomic markers in the plasma samples of subjects from >5 years before death from lung cancer suggested that they are related to the early development of lung cancer. Validation of these biomarkers would have significant implications for the early detection of lung cancer and better management of high-risk patients. JF - Oncology Reports AU - Ali, I U AU - Xiao, Z AU - Malone, W AU - Smith, M AU - Conrads, T P AU - Veenstra, T D AU - Greenwald, P AU - Luke, B T AU - McLarty, J W AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA, alii@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1367 EP - 1372 VL - 15 IS - 5 SN - 1021-335X, 1021-335X KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Manufacturing industry KW - Anions KW - Algorithms KW - Mass spectrometry KW - Mass spectroscopy KW - Risk factors KW - Risk groups KW - Occupational exposure KW - Lung cancer KW - Bioindicators KW - Sensitivity KW - Mortality KW - Pipes KW - Ions KW - Plant diseases KW - Asbestos KW - Desorption KW - biomarkers KW - Cancer KW - USA KW - classification KW - Proteins KW - Lasers KW - proteomics KW - H 1000:Occupational Safety and Health KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20862475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=Plasma+proteomic+profiling%3A+Search+for+lung+cancer+diagnostic+and+early+detection+markers&rft.au=Ali%2C+I+U%3BXiao%2C+Z%3BMalone%2C+W%3BSmith%2C+M%3BConrads%2C+T+P%3BVeenstra%2C+T+D%3BGreenwald%2C+P%3BLuke%2C+B+T%3BMcLarty%2C+J+W&rft.aulast=Ali&rft.aufirst=I&rft.date=2006-05-01&rft.volume=15&rft.issue=5&rft.spage=1367&rft.isbn=&rft.btitle=&rft.title=Oncology+Reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ions; Asbestos; Plant diseases; Desorption; Anions; Algorithms; biomarkers; Mass spectroscopy; Risk factors; Risk groups; Lasers; proteomics; Occupational exposure; Lung cancer; Bioindicators; Pipes; Mortality; Manufacturing industry; Sensitivity; Mass spectrometry; Cancer; classification; Proteins; USA ER - TY - JOUR T1 - Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent AN - 20857998; 8368130 AB - The purpose of this work was to investigate the use of an intravascular contrast agent to determine perfusion kinetics in skeletal muscle. A two-compartment kinetic model was used to represent the flux of contrast agent between the intravascular space and extravascular extracellular space (EES). The relationship between the image signal-to-noise ratio (SNR) and errors in estimating permeability surface area product (Ktrans), interstitial volume (ve), and plasma volume (vp) for linear and nonlinear curve-fitting methods was estimated from Monte Carlo simulations. Similar results were obtained for both methods. For an image SNR of 60, the estimated errors in these parameters were 10%, 22%, and 17%, respectively. In vivo experiments were conducted in rabbits to examine physiological differences between these parameters in the soleus (SOL) and tibialis anterior (TA) muscles in the hind limb. Values for Ktrans were significantly higher in the SOL (3.2 - 0.9 vs. 2.0 - 0.5 X 10-3 min-1), as were values for vp (3.4 - 0.8 vs. 2.1 - 0.7%). Differences in ve for the two muscles (8.7 - 2.2 vs. 8.5 - 1.6%) were not found to be significant. These results demonstrate that relevant physiological metrics can be calculated in skeletal muscle using MRI with an intravascular contrast agent. JF - Magnetic Resonance in Medicine AU - Faranesh, Anthony Z AU - Kraitchman, Dara L AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, faranesh@stanford.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1114 EP - 1123 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Monte Carlo simulation KW - Permeability KW - Perfusion KW - Limbs KW - Surface area KW - Kinetics KW - Magnetic resonance imaging KW - Contrast media KW - N.M.R. KW - Skeletal muscle KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Measurement+of+kinetic+parameters+in+skeletal+muscle+by+magnetic+resonance+imaging+with+an+intravascular+agent&rft.au=Faranesh%2C+Anthony+Z%3BKraitchman%2C+Dara+L%3BMcVeigh%2C+Elliot+R&rft.aulast=Faranesh&rft.aufirst=Anthony&rft.date=2006-05-01&rft.volume=55&rft.issue=5&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20884 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skeletal muscle; Contrast media; Kinetics; Magnetic resonance imaging; Surface area; Models; N.M.R.; Limbs; Monte Carlo simulation; Permeability; Perfusion DO - http://dx.doi.org/10.1002/mrm.20884 ER - TY - JOUR T1 - Electron paramagnetic resonance imaging of tumor hypoxia: Enhanced spatial and temporal resolution for in vivo pO2 determination AN - 20853652; 8368135 AB - The time-domain (TD) mode of electron paramagnetic resonance (EPR) data collection offers a means of estimating the concentration of a paramagnetic probe and the oxygen-dependent linewidth (LW) to generate pO2 maps with minimal errors. A methodology for noninvasive pO2 imaging based on the application of TD-EPR using oxygen-induced LW broadening of a triarylmethyl (TAM)-based radical is presented. The decay of pixel intensities in an image is used to estimate T, which is inversely proportional to pO2. Factors affecting T in each pixel are critically analyzed to extract the contribution of dissolved oxygen to EPR line-broadening. Suitable experimental and image-processing parameters were obtained to produce pO2 maps with minimal artifacts. Image artifacts were also minimized with the use of a novel data collection strategy using multiple gradients. Results from a phantom and in vivo imaging of tumor-bearing mice validated this novel method of noninvasive oximetry. The current imaging protocols achieve a spatial resolution of 1.0 mm and a temporal resolution of 9 s for 2D pO2 mapping, with a reliable oxygen resolution of 1 mmHg (0.12% oxygen in gas phase). This work demonstrates that in vivo oximetry can be performed with good sensitivity, accuracy, and high spatial and temporal resolution. JF - Magnetic Resonance in Medicine AU - Matsumoto, Ken-ichiro AU - Subramanian, Sankaran AU - Devasahayam, Nallathamby AU - Aravalluvan, Thirumaran AU - Murugesan, Ramachandran AU - Cook, John A AU - Mitchell, James B AU - Krishna, Murali C AD - Radiation Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA, murali@helix.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1157 EP - 1163 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - E.S.R. KW - Probes KW - Image processing KW - spatial discrimination KW - Tumors KW - Data collections KW - imaging KW - Dissolved oxygen KW - Oxygen KW - Hypoxia KW - N.M.R. KW - Mapping KW - Radicals KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20853652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Electron+paramagnetic+resonance+imaging+of+tumor+hypoxia%3A+Enhanced+spatial+and+temporal+resolution+for+in+vivo+pO2+determination&rft.au=Matsumoto%2C+Ken-ichiro%3BSubramanian%2C+Sankaran%3BDevasahayam%2C+Nallathamby%3BAravalluvan%2C+Thirumaran%3BMurugesan%2C+Ramachandran%3BCook%2C+John+A%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Matsumoto&rft.aufirst=Ken-ichiro&rft.date=2006-05-01&rft.volume=55&rft.issue=5&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20872 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Oxygen; E.S.R.; Data collections; Dissolved oxygen; Radicals; N.M.R.; spatial discrimination; Image processing; Tumors; Mapping; Hypoxia; Probes DO - http://dx.doi.org/10.1002/mrm.20872 ER - TY - JOUR T1 - ORIGINAL ARTICLE: Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area AN - 20722637; 6776480 AB - Background: Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance. Objectives: To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema. Methods: The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti. Results: More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P < 0.005 compared with controls). The number of lesions was the strongest predictor of frequency of ADLA. Only 18% of the lesions had positive microscopy or culture for fungi (dermatophytes and Scytalidium). Conclusions: These findings highlight the importance of interdigital entry lesions as risk factors for episodes of ADLA and have implications for the control of morbidity from filarial lymphoedema. JF - British Journal of Dermatology AU - McPherson, T AU - Persaud, S AU - Singh, S AU - Fay, M P AU - Addiss, D AU - Nutman, T B AU - Hay, R AD - Centers for Disease Control and Prevention, Atlanta, GA, U.S.A, tnutman@niaid.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 933 EP - 941 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 154 IS - 5 SN - 0007-0963, 0007-0963 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Fungi KW - Filariasis KW - Edema KW - Infection KW - Morbidity KW - Leg KW - Wuchereria bancrofti KW - Limbs KW - Scytalidium KW - Skin diseases KW - Epidemiology KW - Risk factors KW - Microscopy KW - Nematoda KW - Lymphatic system KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Dermatology&rft.atitle=ORIGINAL+ARTICLE%3A+Interdigital+lesions+and+frequency+of+acute+dermatolymphangioadenitis+in+lymphoedema+in+a+filariasis-endemic+area&rft.au=McPherson%2C+T%3BPersaud%2C+S%3BSingh%2C+S%3BFay%2C+M+P%3BAddiss%2C+D%3BNutman%2C+T+B%3BHay%2C+R&rft.aulast=McPherson&rft.aufirst=T&rft.date=2006-05-01&rft.volume=154&rft.issue=5&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Dermatology&rft.issn=00070963&rft_id=info:doi/10.1111%2Fj.1365-2133.2005.07081.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - SuppNotes - Figures, 3; tables, 5; references, 64. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leg; Limbs; Epidemiology; Skin diseases; Fungi; Risk factors; Microscopy; Filariasis; Edema; Infection; Lymphatic system; Morbidity; Wuchereria bancrofti; Scytalidium; Nematoda DO - http://dx.doi.org/10.1111/j.1365-2133.2005.07081.x ER - TY - JOUR T1 - Both Selenoproteins and Low Molecular Weight Selenocompounds Reduce Colon Cancer Risk in Mice with Genetically Impaired Selenoprotein Expression AN - 20718195; 6811633 AB - Selenium has cancer protective effects in a variety of experimental systems. Currently, it is not known whether selenoproteins or low molecular weight selenocompounds are responsible for this activity. To evaluate the contribution of selenoproteins to the cancer protective effects of selenium, we used transgenic mice that carry a mutant selenocysteine transfer RNA gene, which causes reduced selenoprotein synthesis. Selenium homeostasis was characterized in liver and colon of wild-type and transgenic mice fed selenium-deficient diets supplemented with 0, 0.1, or 2.0 mu g selenium (as selenite)/g diet. super(75)Se-labeling, Western blot analysis, and enzymatic activities revealed that transgenic mice have reduced (P < 0.05) liver and colon glutathione peroxidase expression, but conserved thioredoxin reductase expression compared with wild-type mice, regardless of selenium status. Transgenic mice had more (P < 0.05) selenium in the nonprotein fraction of the liver and colon than wild-type mice, indicating a greater amount of low molecular weight selenocompounds. Compared with wild-type mice, transgenic mice had more (P < 0.05) azoxymethane-induced aberrant crypt formation (a preneoplastic lesion for colon cancer). Supplemental selenium decreased (P < 0.05) the number of aberrant crypts and aberrant crypt foci in both wild-type and transgenic mice. These results provide evidence that a lack of selenoprotein activity increases colon cancer susceptibility. Furthermore, low molecular weight selenocompounds reduced preneoplastic lesions independent of the selenoprotein genotype. These results are, to our knowledge, the first to provide evidence that both selenoproteins and low molecular weight selenocompounds are important for the cancer-protective effects of selenium. JF - Journal of Nutrition AU - Irons, Robert AU - Carlson, Bradley A AU - Hatfield, Dolph L AU - Davis, Cindy D AD - Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20852 and Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1311 EP - 1317 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 5 SN - 0022-3166, 0022-3166 KW - Genetics Abstracts; Risk Abstracts KW - enzymatic activity KW - Homeostasis KW - Genotypes KW - Mutants KW - Selenium KW - Glutathione peroxidase KW - Lesions KW - Enzymatic activity KW - Diets KW - Western blotting KW - selenoproteins KW - Selenocysteine KW - Thioredoxin-disulfide reductase KW - Mice KW - selenite KW - Colon cancer KW - Transgenic mice KW - Cancer KW - RNA KW - Liver KW - R2 23060:Medical and environmental health KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20718195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Both+Selenoproteins+and+Low+Molecular+Weight+Selenocompounds+Reduce+Colon+Cancer+Risk+in+Mice+with+Genetically+Impaired+Selenoprotein+Expression&rft.au=Irons%2C+Robert%3BCarlson%2C+Bradley+A%3BHatfield%2C+Dolph+L%3BDavis%2C+Cindy+D&rft.aulast=Irons&rft.aufirst=Robert&rft.date=2006-05-01&rft.volume=136&rft.issue=5&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Western blotting; selenoproteins; Selenocysteine; Thioredoxin-disulfide reductase; selenite; Genotypes; Colon cancer; Homeostasis; Transgenic mice; Selenium; RNA; Glutathione peroxidase; Liver; Enzymatic activity; enzymatic activity; Lesions; Mice; Cancer; Mutants ER - TY - JOUR T1 - Fractionation of Serum Components Using Nanoporous Substrates AN - 20358196; 7599242 AB - Numerous previously uncharacterized molecules resident within the low molecular weight circulatory proteome may provide a picture of the ongoing pathophysiology of an organism. Recently, proteomic signatures composed of low molecular weight molecules have been identified using mass spectrometry combined with bioinformatic algorithms. Attempts to sequence and identify the molecules that underpin the fingerprints are currently underway. The finding that many of these low molecular weight molecules may exist bound to circulating carrier proteins affords a new opportunity for fractionation and separation techniques prior to mass spectrometry-based analysis. In this study we demonstrate a method whereby nanoporous substrates may be used for the facile and reproducible fractionation and selective binding of the serum-based biomarker material, including subcellular proteins found within the serum. Aminopropyl-coated nanoporous silicon, when exposed to serum, can deplete serum of proteins and yield a serum with a distinct, altered MS profile. Additionally, aminopropyl-coated, nanoporous controlled-pore glass beads are able to bind a subset of serum proteins and release them with stringent elution. The eluted proteins have distinct MS profiles, gel electrophoresis profiles, and differential peptide sequence identities, which vary based on the size of the nanopores. These material surfaces could be employed in strategies for the harvesting and preservation of labile and carrier-protein-bound molecules in the blood. JF - Bioconjugate Chemistry AU - Geho, D AU - Cheng, MM-C AU - Killian, K AU - Lowenthal, M AU - Ross, S AU - Frogale, K AU - Nijdam, J AU - Lahar, N AU - Johann, D AU - Herrmann, P AU - Whiteley, G AU - Ferrari, M AU - Petricoin, E AU - Liotta, L AD - Laboratory of Pathology, FDA-NCI Clinical Proteomics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 654 EP - 661 VL - 17 IS - 3 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Algorithms KW - biomarkers KW - Gel electrophoresis KW - Mass spectroscopy KW - Serum proteins KW - Blood KW - Preservation KW - proteomics KW - Bioinformatics KW - Harvesting KW - Separation techniques KW - Glass beads KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Fractionation+of+Serum+Components+Using+Nanoporous+Substrates&rft.au=Geho%2C+D%3BCheng%2C+MM-C%3BKillian%2C+K%3BLowenthal%2C+M%3BRoss%2C+S%3BFrogale%2C+K%3BNijdam%2C+J%3BLahar%2C+N%3BJohann%2C+D%3BHerrmann%2C+P%3BWhiteley%2C+G%3BFerrari%2C+M%3BPetricoin%2C+E%3BLiotta%2C+L&rft.aulast=Geho&rft.aufirst=D&rft.date=2006-05-01&rft.volume=17&rft.issue=3&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0503364 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Silicon; Algorithms; biomarkers; Mass spectroscopy; Gel electrophoresis; Serum proteins; Blood; Bioinformatics; proteomics; Preservation; Separation techniques; Harvesting; Glass beads DO - http://dx.doi.org/10.1021/bc0503364 ER - TY - JOUR T1 - Preventing gene silencing with human replicators AN - 20247539; 6866014 AB - Transcriptional silencing, one of the major impediments to gene therapy in humans, is often accompanied by replication during late S-phase. We report that transcriptional silencing and late replication were prevented by DNA sequences that can initiate DNA replication (replicators). When replicators were included in silencing-prone transgenes, they did not undergo transcriptional silencing, replicated early and maintained histone acetylation patterns characteristic of euchromatin. A mutant replicator, which could not initiate replication, could not prevent gene silencing and replicated late when included in identical transgenes and inserted at identical locations. These observations suggest that replicators introduce epigenetic chromatin changes that facilitate initiation of DNA replication and affect gene silencing. Inclusion of functional replicators in gene therapy vectors may provide a tool for stabilizing gene expression patterns. JF - Nature Biotechnology AU - Fu, Haiqing AU - Wang, Lixin AU - Lin, Chii-Mei AU - Singhania, Sumegha AU - Bouhassira, Eric E AU - Aladjem, Mirit I AD - Laboratory of Molecular Pharmacology, NCI, Bethesda, Maryland 20892, USA., aladjemm@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 572 EP - 576 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 5 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Euchromatin KW - DNA biosynthesis KW - Histones KW - Chromatin KW - Gene therapy KW - Replication KW - Nucleotide sequence KW - Transgenes KW - Expression vectors KW - Gene expression KW - Acetylation KW - Replication initiation KW - epigenetics KW - Gene silencing KW - W3 33181:Gene therapy vectors KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Preventing+gene+silencing+with+human+replicators&rft.au=Fu%2C+Haiqing%3BWang%2C+Lixin%3BLin%2C+Chii-Mei%3BSinghania%2C+Sumegha%3BBouhassira%2C+Eric+E%3BAladjem%2C+Mirit+I&rft.aulast=Fu&rft.aufirst=Haiqing&rft.date=2006-05-01&rft.volume=24&rft.issue=5&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1202 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Euchromatin; Histones; Gene therapy; Chromatin; Replication; Nucleotide sequence; Transgenes; Gene expression; Expression vectors; Acetylation; Replication initiation; epigenetics; Gene silencing DO - http://dx.doi.org/10.1038/nbt1202 ER - TY - JOUR T1 - The E7 Oncoprotein Is Translated from Spliced E6*I Transcripts in High-Risk Human Papillomavirus Type 16- or Type 18-Positive Cervical Cancer Cell Lines via Translation Reinitiation AN - 20228519; 6811733 AB - High-risk human papillomaviruses (HPVs) encode two viral oncoproteins, E6 and E7, from a single bicistronic pre-mRNA containing three exons and two introns. Retention of intron 1 in the E6 coding region is essential for production of the full-length E6 oncoprotein. However, splicing of intron 1 is extremely efficient in cervical cancer cells, leading to the production of a spliced transcript, E6*I, of E6. Here, we investigated whether this splicing of intron 1 might benefit E7 production. Using RNA interference as a tool, we targeted the intron 1 region using small interfering RNAs (siRNAs) in HPV-positive cell lines. At an effective low dose, the siRNAs specifically suppressed E6 expression but not E7 expression, as demonstrated by the stabilization of p53. However, at high doses the HPV18 intron 1-specific siRNA substantially and specifically reduced the level of the 18E6*I mRNA lacking the intron region in HeLa cells, implying its nuclear silencing on the pre-mRNA before RNA splicing. Two other siRNAs targeting the exon 2 regions of HPV16 and -18, which encode the E7 oncoprotein, reduced the E6*I mRNAs to a remarkable extent and preferentially suppressed expression of E7, leading to accumulation of hypophosphorylated p105 super(Rb) and cell cycle arrest, indicating that the majority of E7 proteins are the translational products of E6*I mRNAs. This was confirmed by transient transfection in 293 cells: E7 could be translated only from the E7 open reading frame (ORF) on E6*I mRNA in a distance-dependent matter of upstream E6*I ORF by translation reinitiation. The data thus provide direct evidence that the E6*I mRNAs of high-risk HPVs are responsible for E7 production. JF - Journal of Virology AU - Tang, Shuang AU - Tao, Mingfang AU - McCoy, JPhilip Jr AU - Zheng, Zhi-Ming AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI. Flow Cytometry Core Facility, NHLBI, NIH, Bethesda, Maryland 20892 Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 4249 EP - 4263 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 9 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts; Virology & AIDS Abstracts KW - Translation KW - Data processing KW - Exons KW - Cell cycle KW - Cervical cancer KW - Human papillomavirus 18 KW - double prime E7 protein KW - p53 protein KW - Tumor cell lines KW - Splicing KW - siRNA KW - Transfection KW - Human papillomavirus 16 KW - E7 protein KW - Introns KW - RNA-mediated interference KW - Risk groups KW - Open reading frames KW - Human papillomavirus KW - W 30905:Medical Applications KW - B 26650:Viral Oncogenes KW - V 22114:Human oncogenic viruses KW - N 14050:Post-transcriptional regulation and other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20228519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+E7+Oncoprotein+Is+Translated+from+Spliced+E6*I+Transcripts+in+High-Risk+Human+Papillomavirus+Type+16-+or+Type+18-Positive+Cervical+Cancer+Cell+Lines+via+Translation+Reinitiation&rft.au=Tang%2C+Shuang%3BTao%2C+Mingfang%3BMcCoy%2C+JPhilip+Jr%3BZheng%2C+Zhi-Ming&rft.aulast=Tang&rft.aufirst=Shuang&rft.date=2006-05-01&rft.volume=80&rft.issue=9&rft.spage=4249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; Exons; Cervical cancer; Cell cycle; double prime E7 protein; p53 protein; Splicing; Tumor cell lines; siRNA; Transfection; E7 protein; Introns; Risk groups; RNA-mediated interference; Open reading frames; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus ER - TY - JOUR T1 - Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus AN - 20155885; 6811717 AB - The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) and CD4 T cells and measured [ super(3)H]thymidine incorporation to determine the factors responsible for RSV-induced T-cell suppression. These two cell types were sufficient for RSV-induced suppression of T-cell proliferation in response to cytomegalovirus or Staphylococcus enterotoxin B. Suppressive activity was transferable with supernatants from RSV-infected MDDC and was not due to transfer of live virus or RSV F (fusion) protein. Supernatants from RSV-infected MDDC, but not MDDC exposed to UV-killed RSV or mock conditions, contained alpha interferon (IFN- alpha ; median, 43 pg/ml) and IFN- lambda (approximately 1 to 20 ng/ml). Neutralization of IFN- alpha with monoclonal antibody (MAb) against one of its receptor chains, IFNAR2, or of IFN- lambda with MAb against either of its receptor chains, IFN- lambda R1 (interleukin 28R [IL-28R]) or IL-10R2, had a modest effect. In contrast, blocking the two receptors together markedly reduced or completely blocked the RSV-induced suppression of CD4 T-cell proliferation. Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons. JF - Journal of Virology AU - Chi, Bo AU - Dickensheets, Harold L AU - Spann, Kirsten M AU - Alston, Marc A AU - Luongo, Cindy AU - Dumoutier, Laure AU - Huang, Jiaying AU - Renauld, Jean-Christophe AU - Kotenko, Sergei V AU - Roederer, Mario AU - Beeler, Judy A AU - Donnelly, Raymond P AU - Collins, Peter L AU - Rabin, Ronald L AD - Center for Biologics Evaluation and Research. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Ludwig Institute for Cancer Research, Brussels Branch, and Experimental Medicine Unit, Universite de Louvain, Brussels, Belgium. Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 5032 EP - 5040 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Monoclonal antibodies KW - Staphylococcus KW - Cytomegalovirus KW - Respiratory syncytial virus KW - Dendritic cells KW - CD4 antigen KW - alpha -Interferon KW - Lymphocytes T KW - Monocytes KW - Vaccines KW - Fusion protein KW - enterotoxin B KW - J 02350:Immunology KW - V 22095:Interferon KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20155885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Alpha+and+Lambda+Interferon+Together+Mediate+Suppression+of+CD4+T+Cells+Induced+by+Respiratory+Syncytial+Virus&rft.au=Chi%2C+Bo%3BDickensheets%2C+Harold+L%3BSpann%2C+Kirsten+M%3BAlston%2C+Marc+A%3BLuongo%2C+Cindy%3BDumoutier%2C+Laure%3BHuang%2C+Jiaying%3BRenauld%2C+Jean-Christophe%3BKotenko%2C+Sergei+V%3BRoederer%2C+Mario%3BBeeler%2C+Judy+A%3BDonnelly%2C+Raymond+P%3BCollins%2C+Peter+L%3BRabin%2C+Ronald+L&rft.aulast=Chi&rft.aufirst=Bo&rft.date=2006-05-01&rft.volume=80&rft.issue=10&rft.spage=5032&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dendritic cells; CD4 antigen; Monoclonal antibodies; alpha -Interferon; Lymphocytes T; Fusion protein; Vaccines; Monocytes; enterotoxin B; Respiratory syncytial virus; Staphylococcus; Cytomegalovirus ER - TY - JOUR T1 - Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum- cultured cell lines AN - 19963928; 6834692 AB - The concept of tumor stem cells (TSCs) provides a new paradigm for understanding tumor biology, although it remains unclear whether TSCs will prove to be a more robust model than traditional cancer cell lines. We demonstrate marked phenotypic and genotypic differences between primary human tumor-derived TSCs and their matched glioma cell lines. Unlike the matched, traditionally grown tumor cell lines, TSCs derived directly from primary glioblastomas harbor extensive similarities to normal neural stem cells and recapitulate the genotype, gene expression patterns, and in vivo biology of human glioblastomas. These findings suggest that TSCs may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors. JF - Cancer Cell AU - Lee, Jeongwu AU - Kotliarova, Svetlana AU - Kotliarov, Yuri AU - Li, Aiguo AU - Su, Qin AU - Donin, Nicholas M AU - Pastorino, Sandra AU - Purow, Benjamin W AU - Christopher, Neil AU - Zhang, Wei AU - Park, John K AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, hfine@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 391 EP - 403 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 9 IS - 5 SN - 1535-6108, 1535-6108 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Oncogenes & Growth Factors Abstracts KW - CELLCYCLE KW - HUMDISEASE KW - STEMCELL KW - Gene expression KW - Glioblastoma KW - Tumor cell lines KW - Stem cells KW - Lymphocytes B KW - Glioma cells KW - Genotypes KW - Tumors KW - Epidermal growth factor KW - Fibroblast growth factor 2 KW - Neural stem cells KW - B 26600:Tyrosine Kinase Activity KW - G 07470:Cytogenetics & general KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19963928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Cell&rft.atitle=Tumor+stem+cells+derived+from+glioblastomas+cultured+in+bFGF+and+EGF+more+closely+mirror+the+phenotype+and+genotype+of+primary+tumors+than+do+serum-+cultured+cell+lines&rft.au=Lee%2C+Jeongwu%3BKotliarova%2C+Svetlana%3BKotliarov%2C+Yuri%3BLi%2C+Aiguo%3BSu%2C+Qin%3BDonin%2C+Nicholas+M%3BPastorino%2C+Sandra%3BPurow%2C+Benjamin+W%3BChristopher%2C+Neil%3BZhang%2C+Wei%3BPark%2C+John+K%3BFine%2C+Howard+A&rft.aulast=Lee&rft.aufirst=Jeongwu&rft.date=2006-05-01&rft.volume=9&rft.issue=5&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Cancer+Cell&rft.issn=15356108&rft_id=info:doi/10.1016%2Fj.ccr.2006.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Glioblastoma; Stem cells; Tumor cell lines; Lymphocytes B; Glioma cells; Tumors; Genotypes; Fibroblast growth factor 2; Epidermal growth factor; Neural stem cells DO - http://dx.doi.org/10.1016/j.ccr.2006.03.030 ER - TY - JOUR T1 - Real-time, Image-Guided, Convection-Enhanced Delivery of Interleukin 13 Bound to Pseudomonas Exotoxin AN - 19956968; 6946182 AB - PURPOSE: To determine if the tumor-targeted cytotoxin interleukin 13 bound to Pseudomonas exotoxin (IL13-PE) could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution in real-time using a surrogate magnetic resonance imaging tracer, we used convection-enhanced delivery to perfuse rat and primate brainstems with IL13-PE and gadolinium-bound albumin (Gd-albumin). Experimental Design: Thirty rats underwent convective brainstem perfusion of IL13-PE (0.25, 0.5, or 10 mu g/mL) or vehicle. Twelve primates underwent convective brainstem perfusion of either IL13-PE (0.25, 0.5, or 10 mu g/mL; n = 8), co-infusion of super(125)I-IL13-PE and Gd-albumin (n = 2), or co-infusion of IL13-PE (0.5 mu g/mL) and Gd-albumin (n = 2). The animals were permitted to survive for up to 28 days before sacrifice and histologic assessment. RESULTS: Rats showed no evidence of toxicity at all doses. Primates showed no toxicity at 0.25 or 0.5 mu g/mL but showed clinical and histologic toxicity at 10 mu g/mL. Quantitative autoradiography confirmed that Gd-albumin precisely tracked IL13-PE anatomic distribution and accurately showed the volume of distribution. CONCLUSIONS: IL13-PE can be delivered safely and effectively to the primate brainstem at therapeutic concentrations and over clinically relevant volumes using convection-enhanced delivery. Moreover, the distribution of IL13-PE can be accurately tracked by co-infusion of Gd-albumin using real-time magnetic resonance imaging. JF - Clinical Cancer Research AU - Murad, Gregory JA AU - Walbridge, Stuart AU - Morrison, Paul F AU - Garmestani, Kayhan AU - Degen, Jeffrey W AU - Brechbiel, Martin W AU - Oldfield, Edward H AU - Lonser, Russell R AD - Authors' Affiliations: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3145 EP - 3151 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 10 SN - 1078-0432, 1078-0432 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Perfusion KW - Cytotoxins KW - Interleukin 1 KW - Brain stem KW - Magnetic resonance imaging KW - Pseudomonas KW - Toxicity KW - Autoradiography KW - Primates KW - Exotoxins KW - Tracers KW - Interleukin 13 KW - Albumin KW - J 02410:Animal Diseases KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19956968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Real-time%2C+Image-Guided%2C+Convection-Enhanced+Delivery+of+Interleukin+13+Bound+to+Pseudomonas+Exotoxin&rft.au=Murad%2C+Gregory+JA%3BWalbridge%2C+Stuart%3BMorrison%2C+Paul+F%3BGarmestani%2C+Kayhan%3BDegen%2C+Jeffrey+W%3BBrechbiel%2C+Martin+W%3BOldfield%2C+Edward+H%3BLonser%2C+Russell+R&rft.aulast=Murad&rft.aufirst=Gregory&rft.date=2006-05-01&rft.volume=12&rft.issue=10&rft.spage=3145&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tracers; Interleukin 13; Perfusion; Cytotoxins; Albumin; Magnetic resonance imaging; Brain stem; Interleukin 1; Toxicity; Autoradiography; Exotoxins; Pseudomonas; Primates ER - TY - JOUR T1 - Sodium Antimony Gluconate Induces Generation of Reactive Oxygen Species and Nitric Oxide via Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Activation in Leishmania donovani-Infected Macrophages AN - 19955476; 6812479 AB - Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony gluconate (SAG), are still the first choice for chemotherapy against various forms of leishmaniasis, including visceral leishmaniasis, or kala-azar. Although the requirement of a somewhat functional immune system for the antileishmanial action of antimony was reported previously, the cellular and molecular mechanism of action of SAG was not clear. Herein, we show that SAG induces extracellular signal-regulated kinase 1 (ERK-1) and ERK-2 phosphorylation through phosphoinositide 3-kinase (PI3K), protein kinase C, and Ras activation and p38 mitogen-activated protein kinase (MAPK) phosphorylation through PI3K and Akt activation. ERK-1 and ERK-2 activation results in an increase in the production of reactive oxygen species (ROS) 3 to 6 h after SAG treatment, while p38 MAPK activation and subsequent tumor necrosis factor alpha release result in the production of nitric oxide (NO) 24 h after SAG treatment. Thus, this study has provided the first evidence that SAG treatment induces activation of some important components of the intracellular signaling pathway, which results in an early wave of ROS-dependent parasite killing and a stronger late wave of NO-dependent parasite killing. This opens up the possibility of this metalloid chelate being used in the treatment of various diseases either alone or in combination with other drugs and vaccines. JF - Antimicrobial Agents & Chemotherapy AU - Mookerjee Basu, Jayati AU - Mookerjee, Ananda AU - Sen, Prosenjit AU - Bhaumik, Suniti AU - Sen, Pradip AU - Banerjee, Subha AU - Naskar, Ksudiram AU - Choudhuri, Soumitra K AU - Saha, Bhaskar AU - Raha, Sanghamitra AU - Roy, Syamal AD - Department of Immunology, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India. Department of Crystallography and Molecular Biology, Saha Institute of Nuclear Physics, Kolkata 700064, India. Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata 700026, India. National Centre for Cell Science, Pune 411007, India. Department of Cell Biology and Immunology, Institute of Microbial Technology, Chandigarh 160036, India Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1788 EP - 1797 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 5 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Protein kinase C KW - Macrophages KW - Parasites KW - Molecular modelling KW - Immune system KW - Chemotherapy KW - Cell activation KW - Leishmania donovani KW - Extracellular signal-regulated kinase KW - 1-Phosphatidylinositol 3-kinase KW - Reactive oxygen species KW - Phosphorylation KW - sodium stibogluconate KW - AKT protein KW - phosphoinositides KW - Waves KW - Chelates KW - Drugs KW - Ras protein KW - Intracellular signalling KW - MAP kinase KW - Visceral leishmaniasis KW - Antimicrobial agents KW - Sodium KW - Leishmania KW - Antimony KW - Nitric oxide KW - Tumor necrosis factor- alpha KW - Vaccines KW - K 03086:Immunology & vaccination KW - K 03090:Protozoa: human KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19955476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Sodium+Antimony+Gluconate+Induces+Generation+of+Reactive+Oxygen+Species+and+Nitric+Oxide+via+Phosphoinositide+3-Kinase+and+Mitogen-Activated+Protein+Kinase+Activation+in+Leishmania+donovani-Infected+Macrophages&rft.au=Mookerjee+Basu%2C+Jayati%3BMookerjee%2C+Ananda%3BSen%2C+Prosenjit%3BBhaumik%2C+Suniti%3BSen%2C+Pradip%3BBanerjee%2C+Subha%3BNaskar%2C+Ksudiram%3BChoudhuri%2C+Soumitra+K%3BSaha%2C+Bhaskar%3BRaha%2C+Sanghamitra%3BRoy%2C+Syamal&rft.aulast=Mookerjee+Basu&rft.aufirst=Jayati&rft.date=2006-05-01&rft.volume=50&rft.issue=5&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Protein kinase C; Molecular modelling; Parasites; Chemotherapy; Immune system; Cell activation; Extracellular signal-regulated kinase; 1-Phosphatidylinositol 3-kinase; Phosphorylation; Reactive oxygen species; sodium stibogluconate; AKT protein; phosphoinositides; Waves; Chelates; Drugs; Ras protein; Intracellular signalling; MAP kinase; Visceral leishmaniasis; Antimicrobial agents; Sodium; Antimony; Nitric oxide; Vaccines; Tumor necrosis factor- alpha; Leishmania donovani; Leishmania ER - TY - JOUR T1 - Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma AN - 19955090; 6948003 AB - Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies. In contrast to these tumor-promoting properties, we observed that in an in vivo model of Kaposi's sarcoma (KS), intravenously (i.v.) injected human mesenchymal stem cells (MSCs) home to sites of tumorigenesis and potently inhibit tumor growth. We further show that human MSCs can inhibit the in vitro activation of the Akt protein kinase within some but not all tumor and primary cell lines. The inhibition of Akt activity requires the MSCs to make direct cell-cell contact and can be inhibited by a neutralizing antibody against E-cadherin. We further demonstrate that in vivo, Akt activation within KS cells is potently down-regulated in areas adjacent to MSC infiltration. Finally, the in vivo tumor-suppressive effects of MSCs correlates with their ability to inhibit target cell Akt activity, and KS tumors engineered to express a constitutively activated Akt construct are no longer sensitive to i.v. MSC administration. These results suggest that in contrast to other stem cells or normal stromal cells, MSCs possess intrinsic antineoplastic properties and that this stem cell population might be of particular utility for treating those human malignancies characterized by dysregulated Akt. JF - Journal of Experimental Medicine AU - Khakoo, Aarif Y AU - Pati, Shibani AU - Anderson, Stasia A AU - Reid, William AU - Elshal, Mohamed F AU - Rovira, Ilsa I AU - Nguyen, Ahn T AU - Malide, Daniela AU - Combs, Christian A AU - Hall, Gentzon AU - Zhang, Jianhu AU - Raffeld, Mark AU - Rogers, Terry B AU - Stetler-Stevenson, William AU - Frank, Joseph A AU - Reitz, Marvin AU - Finkel, Toren AD - Laboratory of Molecular Biology, Cardiovascular Branch, Flow Cytometry Core Facility, and Light Microscopy Core Facility, National Heart, Lung, and Blood Institute. Institute of Human Virology, University of Maryland Biotechnology Institute, Department of Microbiology and Immunology, and Department of Biochemistry, School of Medicine, University of Maryland, Baltimore, MD 21201. Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1235 EP - 1247 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 203 IS - 5 SN - 0022-1007, 0022-1007 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - stromal cells KW - Tumorigenesis KW - Cell adhesion KW - Metastases KW - Antibodies KW - Tumor cell lines KW - Malignancy KW - Stem cells KW - Kaposi's sarcoma KW - E- double prime Cadherin KW - AKT protein KW - Protein kinase KW - Mesenchyme KW - F 06152:Tumor Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19955090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Human+mesenchymal+stem+cells+exert+potent+antitumorigenic+effects+in+a+model+of+Kaposi%27s+sarcoma&rft.au=Khakoo%2C+Aarif+Y%3BPati%2C+Shibani%3BAnderson%2C+Stasia+A%3BReid%2C+William%3BElshal%2C+Mohamed+F%3BRovira%2C+Ilsa+I%3BNguyen%2C+Ahn+T%3BMalide%2C+Daniela%3BCombs%2C+Christian+A%3BHall%2C+Gentzon%3BZhang%2C+Jianhu%3BRaffeld%2C+Mark%3BRogers%2C+Terry+B%3BStetler-Stevenson%2C+William%3BFrank%2C+Joseph+A%3BReitz%2C+Marvin%3BFinkel%2C+Toren&rft.aulast=Khakoo&rft.aufirst=Aarif&rft.date=2006-05-01&rft.volume=203&rft.issue=5&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - stromal cells; Tumorigenesis; Cell adhesion; Metastases; Stem cells; Malignancy; Tumor cell lines; Antibodies; Kaposi's sarcoma; E- double prime Cadherin; AKT protein; Protein kinase; Mesenchyme ER - TY - JOUR T1 - Effect of Visible Light on Normal and P23H-3 Transgenic Rat Retinas: Characterization of a Novel Retinoic Acid Derivative Present in the P23H-3 Retina AN - 19848720; 7002678 AB - Transgenic rats with the P23H mutation in rhodopsin exhibit increased susceptibility to light damage, compared with normal animals. It is known that light-induced retinal damage requires repetitive bleaching of rhodopsin and that photoreceptor cell loss is by apoptosis; however, the underlying molecular mechanism(s) leading to photoreceptor cell death are still unknown. Photoproducts, such as all-trans retinal or other retinoid metabolites, released by the extensive bleaching of rhodopsin could lead to activation of degenerative processes, especially in animals genetically predisposed to retinal degenerations. Using wild-type and transgenic rats carrying the P23H opsin mutation, we evaluated the effects of acute intense visible light on retinoid content, type and distribution in ocular tissues. Rats were exposed to green light (480-590 nm) for 0, 5, 10, 30 and 120 min. Following light treatment, rats were sacrificed and neural retinas were dissected free of the retinal pigment epithelium. Retinoids were extracted from retinal tissues and then subjected to HPLC and mass spectral analysis. We found that the light exposure affected relative levels of retinoids in the neural retina and retinal pigment epithelium of wild-type and P23H rat eyes similarly. In the P23H rat retina but not the wild-type rat retina, we found a retinoic acid-like compound with an absorbance maximum of 357 nm and a mass of 304 daltons. Production of this retinoic acid-like compound in transgenic rats is influenced by the age of the animals and the duration of light exposure. It is possible that this unique retinoid may be involved in the process of light-induced retinal degeneration. JF - Photochemistry and Photobiology AU - Duncan, T AU - Wiggert, B AU - Whittaker, N AU - Darrow, R AU - Organisciak, D T AD - Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 741 EP - 745 PB - American Society for Photobiology VL - 82 IS - 3 SN - 0031-8655, 0031-8655 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - High-performance liquid chromatography KW - Age KW - Apoptosis KW - retinal degeneration KW - Bleaching KW - Retina KW - Retinoic acid KW - Metabolites KW - Photoreceptors KW - Light effects KW - opsins KW - retinal pigment epithelium KW - Rhodopsin KW - Absorbance KW - Retinoids KW - Mutation KW - W 30925:Genetic Engineering KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Effect+of+Visible+Light+on+Normal+and+P23H-3+Transgenic+Rat+Retinas%3A+Characterization+of+a+Novel+Retinoic+Acid+Derivative+Present+in+the+P23H-3+Retina&rft.au=Duncan%2C+T%3BWiggert%2C+B%3BWhittaker%2C+N%3BDarrow%2C+R%3BOrganisciak%2C+D+T&rft.aulast=Duncan&rft.aufirst=T&rft.date=2006-05-01&rft.volume=82&rft.issue=3&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/10.1562%2F2005-10-05-RA-712 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0031-8655&volume=82&issue=3&page=741 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Age; Apoptosis; Retina; Bleaching; retinal degeneration; Retinoic acid; Metabolites; Photoreceptors; Light effects; retinal pigment epithelium; opsins; Rhodopsin; Absorbance; Retinoids; Mutation DO - http://dx.doi.org/10.1562/2005-10-05-RA-712 ER - TY - JOUR T1 - Monomeric APOBEC3G Is Catalytically Active and Has Antiviral Activity AN - 19847178; 6811683 AB - APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization of human APO3G and studied the role of APO3G multimerization for catalytic activity, virus encapsidation, and antiviral activity. We found that human APO3G is capable of forming multimeric complexes in transfected HeLa cells. Interestingly, multimerization of APO3G was exquisitely sensitive to RNase treatment, suggesting that interaction of APO3G subunits is facilitated or stabilized by an RNA bridge. Mutation of a conserved cysteine residue (C97) that is part of an N-terminal zinc-finger motif in APO3G abolished multimerization of APO3G; however, the C97 mutation inhibited neither in vitro deaminase activity nor antiviral function of APO3G. These results suggest that monomeric APO3G is both catalytically active and has antiviral activity. Interference studies employing either catalytically inactive or packaging-incompetent APO3G variants suggest that wild-type APO3G is packaged into HIV-1 particles in monomeric form. These results provide novel insights into the catalytic function and antiviral property of APO3G and demonstrate an important role for C97 in the RNA-dependent multimerization of this protein. JF - Journal of Virology AU - Opi, Sandrine AU - Takeuchi, Hiroaki AU - Kao, Sandra AU - Khan, Mohammad A AU - Miyagi, Eri AU - Goila-Gaur, Ritu AU - Iwatani, Yasumasa AU - Levin, Judith G AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892-0460. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 4673 EP - 4682 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 10 SN - 0022-538X, 0022-538X KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - RNA KW - Replication KW - Cysteine KW - Human immunodeficiency virus 1 KW - Ribonuclease KW - Encapsidation KW - Antiviral activity KW - Mutation KW - Cytidine deaminase KW - A 01340:Antibiotics & Antimicrobials KW - V 22002:AIDS: Molecular and in vitro aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Monomeric+APOBEC3G+Is+Catalytically+Active+and+Has+Antiviral+Activity&rft.au=Opi%2C+Sandrine%3BTakeuchi%2C+Hiroaki%3BKao%2C+Sandra%3BKhan%2C+Mohammad+A%3BMiyagi%2C+Eri%3BGoila-Gaur%2C+Ritu%3BIwatani%2C+Yasumasa%3BLevin%2C+Judith+G%3BStrebel%2C+Klaus&rft.aulast=Opi&rft.aufirst=Sandrine&rft.date=2006-05-01&rft.volume=80&rft.issue=10&rft.spage=4673&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - RNA; Cysteine; Replication; Encapsidation; Ribonuclease; Antiviral activity; Cytidine deaminase; Mutation; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor- beta / delta (PPAR beta / delta ) AN - 19844746; 6812945 AB - Inhibition of cyclooxygenase-2 (COX2) by non-steroidal anti-inflammatory drugs (NSAID) is known to suppress skin carcinogenesis. It was further suggested that inhibition of COX2-derived prostaglandins by NSAIDs could reduce levels of putative endogenous ligands of peroxisome proliferator-activated receptor- beta (PPAR beta ), and these ligands could potentiate tumorigenesis. However, it is currently unclear whether ligand activation of PPAR beta either inhibits or potentiates carcinogenesis. The present studies were designed to examine the mechanism of NSAID-mediated chemoprevention in skin, and, in particular, to determine the role of PPAR beta in this process. A two-stage skin carcinogenicity bioassay was performed using wild-type and PPAR beta -null mice that were fed either a control diet or one containing 0.32 g sulindac/kg diet. Significant inhibition of chemically induced skin carcinogenesis was observed in both wild-type and PPAR beta -null mice, and this was associated with a marked decrease in the concentration of skin prostaglandins including PGE sub(2) and PGI sub(2). Results from these studies demonstrate that inhibition of COX2 by dietary sulindac in mouse skin can effectively inhibit chemically induced skin carcinogenesis, and suggest that the mechanism underlying this chemopreventive effect is independent of PPAR beta . Additionally, results from these studies do not support the hypothesis that ligand activation of PPAR beta by COX-derived metabolites potentiates chemically induced skin carcinogenesis. JF - Carcinogenesis AU - Kim, Dae J AU - Prabhu, KSandeep AU - Gonzalez, Frank J AU - Peters, Jeffrey M AD - Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA, Graduate Program in Molecular Toxicology, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA and Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, 20892, USA Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1105 EP - 1112 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 5 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Cyclooxygenase-2 KW - Diets KW - Skin KW - Peroxisome proliferator-activated receptors KW - Carcinogenesis KW - sulindac KW - Tumorigenesis KW - Metabolites KW - Prostaglandin E2 KW - Nonsteroidal antiinflammatory drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+chemically+induced+skin+carcinogenesis+by+sulindac+is+independent+of+peroxisome+proliferator-activated+receptor-+beta+%2F+delta+%28PPAR+beta+%2F+delta+%29&rft.au=Kim%2C+Dae+J%3BPrabhu%2C+KSandeep%3BGonzalez%2C+Frank+J%3BPeters%2C+Jeffrey+M&rft.aulast=Kim&rft.aufirst=Dae&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Cyclooxygenase-2; Skin; Peroxisome proliferator-activated receptors; Tumorigenesis; sulindac; Carcinogenesis; Metabolites; Prostaglandin E2; Nonsteroidal antiinflammatory drugs ER - TY - JOUR T1 - Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations AN - 19772448; 6949387 AB - By representing the high-resolution crystal structures of a number of enzymes using the elastic network model, it has been shown that only a few low-frequency normal modes are needed to describe the large-scale domain movements that are triggered by ligand binding. Here we explore a link between the nearly invariant nature of the modes that describe functional dynamics at the mesoscopic level and the large evolutionary sequence variations at the residue level. By using a structural perturbation method (SPM), which probes the residue-specific response to perturbations (or mutations), we identify a sparse network of strongly conserved residues that transmit allosteric signals in three structurally unrelated biological nanomachines, namely, DNA polymerase, myosin motor, and the Escherichia coli chaperonin. Based on the response of every mode to perturbations, which are generated by interchanging specific sequence pairs in a multiple sequence alignment, we show that the functionally relevant low-frequency modes are most robust to sequence variations. Our work shows that robustness of dynamical modes at the mesoscopic level is encoded in the structure through a sparse network of residues that transmit allosteric signals. JF - Proceedings of the National Academy of Sciences, USA AU - Zheng, Wenjun AU - Brooks, Bernard R AU - Thirumalai, D AD - Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 7664 EP - 7669 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 20 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Nucleotide sequence KW - Chaperonins KW - Probes KW - Enzymes KW - Models KW - Myosin KW - Allosteric properties KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Crystal structure KW - Mutation KW - Evolution KW - J 02310:Genetics & Taxonomy KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Low-frequency+normal+modes+that+describe+allosteric+transitions+in+biological+nanomachines+are+robust+to+sequence+variations&rft.au=Zheng%2C+Wenjun%3BBrooks%2C+Bernard+R%3BThirumalai%2C+D&rft.aulast=Zheng&rft.aufirst=Wenjun&rft.date=2006-05-01&rft.volume=103&rft.issue=20&rft.spage=7664&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Myosin; DNA-directed DNA polymerase; Nucleotide sequence; Allosteric properties; Chaperonins; Probes; Crystal structure; Enzymes; Mutation; Evolution; Models; Escherichia coli ER - TY - JOUR T1 - Tendon and neurovascular bundle displacement in the palm with hand flexion and extension: An MRI and gross anatomy correlative study AN - 19679959; 7456928 AB - This study evaluated the correlative use of MRI methods and gross anatomy to monitor tendon displacement in the central region of the palm at rest and during flexion and extension of the metacarpophalangeal and interphalangeal joints with respect to the corresponding neurovascular bundles (NVBs). In all of the samples the neutral and extended positions showed the NVB to be palmar with respect to the flexor tendons, while during flexion tendon displacement caused the NVB to be dorsal to both the flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) tendons. T1-weighted MR images correlated with gross anatomical slides demonstrated that significant changes occur in the relative positions of the flexor tendons and associated NVBs of the palm upon flexion and extension. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Canuto, Holly C AU - Oliveira, Miguel LR AU - Fishbein, Kenneth W AU - Spencer, Richard G AD - Nuclear Magnetic Resonance Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, spencerri@grc.nia.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 742 EP - 746 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 5 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - MR imaging KW - palm KW - tendon KW - neurovascular bundle (NVBs) KW - cadavers KW - Magnetic resonance imaging KW - Tendons KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19679959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Tendon+and+neurovascular+bundle+displacement+in+the+palm+with+hand+flexion+and+extension%3A+An+MRI+and+gross+anatomy+correlative+study&rft.au=Canuto%2C+Holly+C%3BOliveira%2C+Miguel+LR%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G&rft.aulast=Canuto&rft.aufirst=Holly&rft.date=2006-05-01&rft.volume=23&rft.issue=5&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20558 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Tendons DO - http://dx.doi.org/10.1002/jmri.20558 ER - TY - JOUR T1 - Gestational Mercury Vapor Exposure and Diet Contribute to Mercury Accumulation in Neonatal Rats AN - 19589274; 7305629 AB - Exposure of pregnant Long-Evans rats to elemental mercury (Hg super(0)) vapor resulted in a significant accumulation of Hg in tissues of neonates. Because elevated Hg in neonatal tissues may adversely affect growth and development, we were interested in how rapidly Hg was eliminated from neonatal tissues. Pregnant rats were exposed to 1, 2, or 4 mg Hg super(0) vapor/m super(3) or air (controls) for 2 hr/day from gestation day 6 (GD6) through GD15. Neonatal brain, liver, and kidney were analyzed for total Hg at various times between birth and postnatal day 90 (PND90). Milk was analyzed for Hg between birth and weaning (PND21). Before weaning, the Hg levels in neonatal tissues were proportional to maternal exposure concentrations and were highest in kidney followed by liver and then brain. There was no elimination of Hg between birth and weaning, indicating that neonates were exposed continuously to elevated levels of Hg during postpartum growth and development. Consumption of milk from exposed dams resulted in a slight increase in kidney Hg concentration during this period. Unexpectedly, neonatal Hg accumulation increased rapidly after weaning. Increased Hg was measured in both control and exposed neonates and was attributed to consumption of NIH-07 diet containing trace levels of Hg. By PND90, tissue Hg levels equilibrated at concentrations similar to those in unexposed adult Long-Evans rats fed the same diet. These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg super(0) vapor. JF - Environmental Health Perspectives AU - Morgan, D L AU - Price, H C AU - Fernando, R AU - Chanda, S M AU - O'Connor, R W AU - Barone, SS Jr AU - Herr, D W AU - Beliles, R P AD - Respiratory Toxicology, Mail Stop IF-00, NIEHS, 101 TW Alexander Dr., P.O. Box 12233, Research Triangle Park, NC 27709 USA, morgan3@niehs.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 735 EP - 739 VL - 114 IS - 5 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Diets KW - Milk KW - Brain KW - Weaning KW - Pregnancy KW - Birth KW - Postpartum KW - Vapors KW - Gestation KW - Liver KW - Kidney KW - Mercury KW - Neonates KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19589274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Gestational+Mercury+Vapor+Exposure+and+Diet+Contribute+to+Mercury+Accumulation+in+Neonatal+Rats&rft.au=Morgan%2C+D+L%3BPrice%2C+H+C%3BFernando%2C+R%3BChanda%2C+S+M%3BO%27Connor%2C+R+W%3BBarone%2C+SS+Jr%3BHerr%2C+D+W%3BBeliles%2C+R+P&rft.aulast=Morgan&rft.aufirst=D&rft.date=2006-05-01&rft.volume=114&rft.issue=5&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Feph.8754 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Milk; Brain; Weaning; Pregnancy; Birth; Vapors; Postpartum; Gestation; Kidney; Liver; Mercury; Neonates DO - http://dx.doi.org/10.1289/eph.8754 ER - TY - JOUR T1 - Three-dimensional ultrasound in the prenatal diagnosis of cleidocranial dysplasia associated with B-cell immunodeficiency AN - 19549644; 8633137 AB - A patient with a singleton pregnancy was referred for three-dimensional ultrasonography (3DUS) at 18 + 3 weeks for suspected hypomineralization of the skull bones and absence of the nasal bones. Three-dimensional rendered images of the fetal skull revealed widening of the coronal sutures, absence of the squamous portion of the temporal bone, and absence of the occipital bone, except for two areas of ossification. In addition, a fractured right clavicle was identified. The remainder of the fetal anatomy was normal and biometry was appropriate for gestational age. Genetic amniocentesis revealed a 46,XX fetal karyotype. Family history was positive for a 5-year-old sibling with an open anterior fontanelle. Cleidocranial dysplasia was suspected. A female neonate was delivered by elective repeat Cesarean section at 40 + 3 weeks of gestation without complications and discharged home 3 days after delivery. Prenatal diagnosis was confirmed by physical and radiological evaluation. The infant died at 8 weeks of age due to respiratory syncytial virus pneumonia secondary to B-cell deficiency. RUNX2 mutations were not detected by molecular analysis. There are three relevant aspects to this case: (1) clear visualization of the widened fontanelles and hypomineralized occipital bones was possible with the use of 3DUS; (2) a clavicular fracture was identified in utero with combined high-resolution two-dimensional and 3DUS; and (3) although absence of the nasal bones is most commonly observed in fetuses with chromosomal disorders (e.g. trisomy 21 and trisomy 18), a careful examination of the skeleton should be considered in fetuses with absent nasal bones and a normal karyotype. JF - Ultrasound in Obstetrics and Gynecology AU - Soto, E AU - Richani, K AU - Goncalves, L F AU - Devers, P AU - Espinoza, J AU - Lee, W AU - Treadwell, M C AU - Romero, R AD - Perinatology Research Branch, NICHD, NIH, DHHS, Department of Obstetrics and Gynecology, Detroit, USA, warfiela@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 574 EP - 579 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 27 IS - 5 SN - 0960-7692, 0960-7692 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Gynecology KW - Craniofacial syndromes KW - Immunodeficiency KW - Mineralization KW - Karyotypes KW - Occipital bone KW - Skull KW - Siblings KW - Ultrasound KW - Clavicle KW - Temporal bone KW - Sutures KW - Lymphocytes B KW - Cbfa-1 protein KW - Fractures KW - Trisomy KW - Prenatal diagnosis KW - Ultrasonography KW - Fetuses KW - Pregnancy KW - Respiratory syncytial virus KW - Bone KW - Ossification KW - Amniocentesis KW - Cesarean section KW - Obstetrics KW - Mutation KW - Pneumonia KW - Skeleton KW - Infants KW - W 30910:Imaging KW - V 22400:Human Diseases KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19549644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Three-dimensional+ultrasound+in+the+prenatal+diagnosis+of+cleidocranial+dysplasia+associated+with+B-cell+immunodeficiency&rft.au=Soto%2C+E%3BRichani%2C+K%3BGoncalves%2C+L+F%3BDevers%2C+P%3BEspinoza%2C+J%3BLee%2C+W%3BTreadwell%2C+M+C%3BRomero%2C+R&rft.aulast=Soto&rft.aufirst=E&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.2770 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Gynecology; Craniofacial syndromes; Immunodeficiency; Mineralization; Karyotypes; Occipital bone; Skull; Siblings; Ultrasound; Clavicle; Temporal bone; Lymphocytes B; Sutures; Cbfa-1 protein; Fractures; Trisomy; Prenatal diagnosis; Ultrasonography; Fetuses; Pregnancy; Bone; Amniocentesis; Ossification; Cesarean section; Mutation; Obstetrics; Pneumonia; Infants; Skeleton; Respiratory syncytial virus DO - http://dx.doi.org/10.1002/uog.2770 ER - TY - JOUR T1 - Multilaboratory Evaluation of Disk Diffusion Antimicrobial Susceptibility Testing of Neisseria meningitidis Isolates AN - 19522246; 6812594 AB - In 2005, the Clinical and Laboratory Standards Institute published MIC interpretive criteria for 13 antimicrobial agents used for either therapy or prophylaxis of Neisseria meningitidis infections. The MIC method includes the use of lysed horse blood-supplemented Mueller-Hinton broth with incubation in 5% CO sub(2) for 20 to 24 h. Since some clinical laboratories might prefer the option of disk diffusion testing for infrequently encountered isolates a multicenter collaborative study was conducted to evaluate the reproducibility of a disk diffusion method for testing isolates of N. meningitidis. Interpretive criteria were developed for 12 antimicrobial agents. Four laboratories tested a common collection of 50 meningococcal strains and then tested 25 unique isolates per laboratory. Isolates were tested using Mueller-Hinton sheep blood agar plates incubated for 20 to 24 h in 5% CO sub(2); they were also tested by the reference broth microdilution method in parallel. Pooling of the MIC and disk diffusion data from the common and unique isolates provided a sufficient sample size to develop susceptible, intermediate, and resistant zone diameter interpretive criteria using the error rate-bounded method for the following agents: chloramphenicol, trimethoprim-sulfamethoxazole, ciprofloxacin, and rifampin. Due to the lack of resistant strains at the present time, "susceptible only" interpretive criteria were proposed for cefotaxime, ceftriaxone, meropenem, azithromycin, and minocycline. The numbers of minor interpretive errors with penicillin and ampicillin disk tests were unacceptably high and precluded recommended testing of those agents by the disk method. However, amdinocillin, an agent that preferentially binds to the altered penicillin binding protein responsible for diminished penicillin susceptibility, has potential utility as a surrogate screening reagent for ampicillin resistance. A disk diffusion breakpoint was derived for nalidixic acid to serve as a surrogate marker for gyrase A mutations associated with diminished fluoroquinolone susceptibility. Disk diffusion testing with meningococci can be performed in a reproducible manner with several antimicrobial agents and represents a practical and cost-effective option for testing sporadic clinical isolates or for surveillance purposes by resource-limited laboratories. JF - Journal of Clinical Microbiology AU - Jorgensen, James H AU - Crawford, Sharon A AU - Fulcher, Letitia C AU - Glennen, Anita AU - Harrington, Susan M AU - Swenson, Jana AU - Lynfield, Ruth AU - Murray, Patrick R AU - Tenover, Fred C AD - Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229. Minnesota Department of Health, St. Paul, Minnesota 55155. Department of Laboratory Medicine, The National Institutes of Health Clinical Center, Bethesda, Maryland 20892. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1744 EP - 1754 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 5 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Agar KW - Minocycline KW - Neisseria meningitidis KW - Infection KW - DNA gyrase KW - Breakpoints KW - Rifampin KW - Ciprofloxacin KW - Meropenem KW - Azithromycin KW - Nalidixic acid KW - Diffusion KW - Amdinocillin KW - Clinical isolates KW - Chloramphenicol KW - Cefotaxime KW - Data processing KW - Fluoroquinolones KW - DNA topoisomerase KW - Ampicillin KW - trimethoprim-sulfamethoxazole KW - Ceftriaxone KW - Minimum inhibitory concentration KW - Penicillin KW - Antimicrobial agents KW - Blood KW - Prophylaxis KW - Carbon dioxide KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - J 02848:Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Multilaboratory+Evaluation+of+Disk+Diffusion+Antimicrobial+Susceptibility+Testing+of+Neisseria+meningitidis+Isolates&rft.au=Jorgensen%2C+James+H%3BCrawford%2C+Sharon+A%3BFulcher%2C+Letitia+C%3BGlennen%2C+Anita%3BHarrington%2C+Susan+M%3BSwenson%2C+Jana%3BLynfield%2C+Ruth%3BMurray%2C+Patrick+R%3BTenover%2C+Fred+C&rft.aulast=Jorgensen&rft.aufirst=James&rft.date=2006-05-01&rft.volume=44&rft.issue=5&rft.spage=1744&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Agar; Minocycline; DNA gyrase; Infection; Ciprofloxacin; Rifampin; Breakpoints; Azithromycin; Meropenem; Nalidixic acid; Diffusion; Amdinocillin; Clinical isolates; Chloramphenicol; Data processing; Cefotaxime; Fluoroquinolones; DNA topoisomerase; Ampicillin; trimethoprim-sulfamethoxazole; Ceftriaxone; Minimum inhibitory concentration; Penicillin; Antimicrobial agents; Blood; Prophylaxis; Carbon dioxide; Mutation; Neisseria meningitidis ER - TY - JOUR T1 - Body mass index and all-cause mortality in a nationwide US cohort AN - 19514471; 7211864 AB - Objective: To investigate whether the nature of the relationship between body mass index (BMI (kg/m super(2))) and all-cause mortality is direct, J- or U-shaped, and whether this relationship changes as people age. Design: Prospective nationwide cohort study of US radiologic technologists (USRT). Subjects: Sixty-four thousand seven hundred and thirty-three female and 19 011 male certified radiation technologists. Methods: We prospectively followed participants from the USRT study who completed a mail survey in 1983-1989 through 2000. During an average of 14.7 years of follow-up or 1.23 million person-years, 2278 women and 1495 men died. Using Cox's proportional-hazards regression analyses, we analyzed the relationship between BMI and all-cause mortality by gender and by age group (< 55 years; greater than or equal to 55 years). We also examined risk in never-smokers after the first 5 years of follow-up to limit bias owing to the confounding effects of smoking and illness-related weight loss on BMI and mortality. Results: Risks were generally J-shaped for both genders and age groups. When we excluded smokers and the first 5 year of follow-up, risks were substantially reduced in those with low BMIs. In never-smoking women under the age of 55 years (excluding the initial 5-year follow-up period), risk rose as BMI increased above 21.0 kg/m super(2), whereas in older women, risk increased beginning at a higher BMI ( greater than or equal to 25.0 kg/m super(2)). Among younger men who never smoked (excluding the initial 5-year follow-up period), risk began to rise above a BMI of 23.0 kg/m super(2), whereas in older men, risk did not begin to increase until exceeding a BMI of 30.0 kg/m super(2). Conclusions: In younger/middle-aged, but not older, women and men, mortality risks appear directly related to BMI. The more complicated relationship between BMI and mortality in older subjects suggests the importance of assessing whether other markers of body composition better explain mortality risk in older adults. JF - International Journal of Obesity AU - Freedman, D M AU - Ron, E AU - Ballard-Barbash, R AU - Doody, M M AU - Linet AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 7036, 6120 Executive Boulevard, Bethesda, MD 20892, USA, mf101e@nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 822 EP - 829 VL - 30 IS - 5 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Risk Abstracts KW - Mortality KW - age groups KW - Obesity KW - Weight control KW - Men KW - Body mass KW - Women KW - obesity KW - Gerontology KW - Surveys KW - Adults KW - Smoking KW - USA KW - body mass KW - Analysis KW - Gender KW - Body composition KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19514471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Body+mass+index+and+all-cause+mortality+in+a+nationwide+US+cohort&rft.au=Freedman%2C+D+M%3BRon%2C+E%3BBallard-Barbash%2C+R%3BDoody%2C+M+M%3BLinet&rft.aulast=Freedman&rft.aufirst=D&rft.date=2006-05-01&rft.volume=30&rft.issue=5&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0803193 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smoking; Obesity; Weight control; Men; Body mass; Analysis; Gender; Women; Gerontology; Surveys; Adults; Body composition; age groups; Mortality; body mass; obesity; USA DO - http://dx.doi.org/10.1038/sj.ijo.0803193 ER - TY - JOUR T1 - The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans AN - 19452903; 6776844 AB - Context: Both obesity (body mass index, BMI greater than or equal to 30 kg/m super(2)) and Black race are associated with a higher risk of vitamin D deficiency and secondary hyperparathyroidism. We hypothesized the risk of hypovitaminosis D would therefore be extraordinarily high in obese Black adults. Objective: To study the effects of race and adiposity on 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (iPTH). Design, Setting and Participants: Cross-sectional study of 379 Black and White adults from the Washington D.C. area. BMI ranged from 19.9 to 58.2 kg/m super(2). Main Outcome Measures: Prevalence of hypovitaminosis D [25(OH)D 4.2 pmol/l]. Results: Obese Black subjects had lower mean 25(OH)D, 40.3 (SD, 20.3) nmol/l, compared with obese Whites, 64.5 (29.7), P < 0.001, nonobese Blacks, 53.3 (26.0), P = 0.0025 and nonobese Whites, 78.0 (33.5), P < 0.001. The prevalence of hypovitaminosis D increased with increasing BMI, and was greater (P < 0.001) in Blacks than Whites within all BMI categories examined. Among subjects with BMI greater than or equal to 35 kg/m super(2), 59% of Blacks vs 18% of Whites had hypovitaminosis D (odds ratio 6.5, 95% confidence interval 3.0-14.2). iPTH was negatively correlated with 25(OH)D (r = -0.31, P < 0.0001), suggesting those with hypovitaminosis D had clinically important vitamin D deficiency with secondary hyperparathyroidism. For secondary hyperparathyroidism 35.2% of Blacks met the criteria, compared to 9.7% of Whites (OR 3.6, CI 1.5-98.8). Conclusions: Obese Black Americans are at particularly high risk for vitamin D deficiency and secondary hyperparathyroidism. Physicians should consider routinely supplementing such patients with vitamin D or screening them for hypovitaminosis D. JF - Clinical Endocrinology AU - Yanoff, Lisa B AU - Parikh, Shamik J AU - Spitalnik, Amanda AU - Denkinger, Blakeley AU - Sebring, Nancy G AU - Slaughter, Pamela AU - McHugh, Theresa AU - Remaley, Alan T AU - Yanovski, Jack A AD - Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892; Departments of Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 523 EP - 529 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 64 IS - 5 SN - 0300-0664, 0300-0664 KW - Physical Education Index KW - Obesity KW - Blacks KW - Vitamins KW - Body mass KW - Patients KW - Physicians KW - Adults KW - Hormones KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19452903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Endocrinology&rft.atitle=The+prevalence+of+hypovitaminosis+D+and+secondary+hyperparathyroidism+in+obese+Black+Americans&rft.au=Yanoff%2C+Lisa+B%3BParikh%2C+Shamik+J%3BSpitalnik%2C+Amanda%3BDenkinger%2C+Blakeley%3BSebring%2C+Nancy+G%3BSlaughter%2C+Pamela%3BMcHugh%2C+Theresa%3BRemaley%2C+Alan+T%3BYanovski%2C+Jack+A&rft.aulast=Yanoff&rft.aufirst=Lisa&rft.date=2006-05-01&rft.volume=64&rft.issue=5&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Clinical+Endocrinology&rft.issn=03000664&rft_id=info:doi/10.1111%2Fj.1365-2265.2006.02502.x LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - SuppNotes - Figures, 3; tables, 2; references, 38. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Blacks; Body mass; Vitamins; Physicians; Patients; Adults; Hormones DO - http://dx.doi.org/10.1111/j.1365-2265.2006.02502.x ER - TY - JOUR T1 - The neural basis of implicit moral attitude - An IAT study using event-related fMRI AN - 19446987; 6837131 AB - Recent models of morality have suggested the importance of affect-based automatic moral attitudes in moral reasoning. However, previous investigations of moral reasoning have frequently relied upon explicit measures that are susceptible to voluntary control. To investigate participant's automatic moral attitudes, we used a morality Implicit Association Test (IAT). Participants rated the legality of visually depicted legal and illegal behaviors of two different intensity levels (e.g., high intensity illegal = interpersonal violence; low intensity illegal = vandalism) both when the target concept (e.g., illegal) was behaviorally paired with an associated attribute (e.g., bad; congruent condition) or an unassociated attribute (e.g., good; incongruent condition). Behaviorally, an IAT effect was shown; RTs were faster in the congruent rather than incongruent conditions. At the neural level, implicit moral attitude, as indexed by increased BOLD response as a function of stimulus intensity, was associated with increased activation in the right amygdala and the ventromedial orbitofrontal cortex. In addition, performance on incongruent trials relative to congruent trials was associated with increased activity in the right ventrolateral prefrontal cortex (BA 47), left subgenual cingulate gyrus (BA 25), bilateral premotor cortex (BA 6) and the left caudate. The functional contributions of these regions in moral reasoning are discussed. JF - NeuroImage AU - Luo, Qian AU - Nakic, Marina AU - Wheatley, Thalia AU - Richell, Rebecca AU - Martin, Alex AU - Blair, RJames R AD - Unit on Affective Cognitive Neuroscience, Mood and Anxiety Program, National Institute of Mental Health, Department of Health and Human Services, 15K North Drive, Room 206, MSC 2670, Bethesda, MD 20892, USA, James.Blair@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1449 EP - 1457 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional magnetic resonance imaging KW - Cortex (cingulate) KW - Cortex (premotor) KW - Ethics KW - Amygdala KW - Aggression KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+neural+basis+of+implicit+moral+attitude+-+An+IAT+study+using+event-related+fMRI&rft.au=Luo%2C+Qian%3BNakic%2C+Marina%3BWheatley%2C+Thalia%3BRichell%2C+Rebecca%3BMartin%2C+Alex%3BBlair%2C+RJames+R&rft.aulast=Luo&rft.aufirst=Qian&rft.date=2006-05-01&rft.volume=30&rft.issue=4&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethics; Cortex (prefrontal); Cortex (premotor); Cortex (cingulate); Amygdala; Aggression; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2005.11.005 ER - TY - JOUR T1 - Designing a Nanotube Using Naturally Occurring Protein Building Blocks AN - 19444419; 6933213 AB - Here our goal is to carry out nanotube design using naturally occurring protein building blocks. Inspection of the protein structural database reveals the richness of the conformations of proteins, their parts, and their chemistry. Given target functional protein nanotube geometry, our strategy involves scanning a library of candidate building blocks, combinatorially assembling them into the shape and testing its stability. Since self-assembly takes place on time scales not affordable for computations, here we propose a strategy for the very first step in protein nanotube design: we map the candidate building blocks onto a planar sheet and wrap the sheet around a cylinder with the target dimensions. We provide examples of three nanotubes, two peptide and one protein, in atomistic model detail for which there are experimental data. The nanotube models can be used to verify a nanostructure observed by low-resolution experiments, and to study the mechanism of tube formation. JF - PLoS Computational Biology AU - Tsai, Chung-Jung AU - Zheng, Jie AU - Nussinov, Ruth AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research, Nanobiology Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America, ruthn@ncifcrf.gov Y1 - 2006/05// PY - 2006 DA - May 2006 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 2 IS - 4 SN - 1553-734X, 1553-734X KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Scanning KW - Self-assembly KW - nanotubes KW - Computer applications KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19444419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Computational+Biology&rft.atitle=Designing+a+Nanotube+Using+Naturally+Occurring+Protein+Building+Blocks&rft.au=Tsai%2C+Chung-Jung%3BZheng%2C+Jie%3BNussinov%2C+Ruth&rft.aulast=Tsai&rft.aufirst=Chung-Jung&rft.date=2006-05-01&rft.volume=2&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Computational+Biology&rft.issn=1553734X&rft_id=info:doi/10.1371%2Fjournal.pcbi.0020042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - nanotubes; Models; Self-assembly; Scanning; Databases; Computer applications DO - http://dx.doi.org/10.1371/journal.pcbi.0020042 ER - TY - JOUR T1 - Analysis and validation of automated skull stripping tools: A validation study based on 296 MR images from the Honolulu Asia aging study AN - 19443142; 6837062 AB - As population-based epidemiologic studies may acquire images from thousands of subjects, automated image post-processing is needed. However, error in these methods may be biased and related to subject characteristics relevant to the research question. Here, we compare two automated methods of brain extraction against manually segmented images and evaluate whether method accuracy is associated with subject demographic and health characteristics. MRI data (n = 296) are from the Honolulu Asia Aging Study, a population-based study of elderly Japanese-American men. The intracranial space was manually outlined on the axial proton density sequence by a single operator. The brain was extracted automatically using BET (Brain Extraction Tool) and BSE (Brain Surface Extractor) on axial proton density images. Total intracranial volume was calculated for the manually segmented images (ticvM), the BET segmented images (ticvBET) and the BSE segmented images (ticvBSE). Mean ticvBSE was closer to that of ticvM, but ticvBET was more highly correlated with ticvM than ticvBSE. BSE had significant over (positive error) and underestimated (negative error) ticv, but net error was relatively low. BET had large positive and very low negative error. Method accuracy, measured in percent positive and negative error, varied slightly with age, head circumference, presence of the apolipoprotein e epsilon 4 polymorphism, subcortical and cortical infracts and enlarged ventricles. This epidemiologic approach to the assessment of potential bias in image post-processing tasks shows both skull-stripping programs performed well in this large image dataset when compared to manually segmented images. Although method accuracy was statistically associated with some subject characteristics, the extent of the misclassification (in terms of percent of brain volume) was small. JF - NeuroImage AU - Hartley, S W AU - Scher, AI AU - Korf, ESC AU - White, L R AU - Launer, L J AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA, ascher@usuhs.mil Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1179 EP - 1186 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Apolipoproteins KW - Magnetic resonance imaging KW - Aging KW - Automation KW - Demography KW - Cortex KW - Skull KW - Geriatrics KW - Head KW - Protons KW - Brain KW - Population studies KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19443142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Analysis+and+validation+of+automated+skull+stripping+tools%3A+A+validation+study+based+on+296+MR+images+from+the+Honolulu+Asia+aging+study&rft.au=Hartley%2C+S+W%3BScher%2C+AI%3BKorf%2C+ESC%3BWhite%2C+L+R%3BLauner%2C+L+J&rft.aulast=Hartley&rft.aufirst=S&rft.date=2006-05-01&rft.volume=30&rft.issue=4&rft.spage=1179&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.10.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Geriatrics; Protons; Aging; Skull; Head; Apolipoproteins; Demography; Population studies; Cortex; Magnetic resonance imaging; Automation DO - http://dx.doi.org/10.1016/j.neuroimage.2005.10.043 ER - TY - JOUR T1 - Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis AN - 19441758; 6812941 AB - Peroxisome proliferators, such as lipid-lowering fibrate drugs, are agonists for the peroxisome proliferator-activated receptor alpha (PPAR alpha ). Sustained activation of PPAR alpha leads to the development of liver tumors in rodents. Paradoxically, humans appear to be resistant to the induction of peroxisome proliferation and development of liver tumors by peroxisome proliferators. To examine the species differences in response to peroxisome proliferators, a PPAR alpha humanized mouse (hPPAR alpha ) was generated, in which the human PPAR alpha was expressed in liver under control of the Tet-OFF system. To evaluate the susceptibility of hPPAR alpha mice to peroxisome proliferator-induced hepatocarcinogenesis, a long-term feeding study of Wy-14,643 was carried out. hPPAR alpha and wild-type (mPPAR alpha ) mice were fed either a control diet or one containing 0.1% Wy-14,643 for 44 and 38 weeks, respectively. Gene expression analysis for peroxisomal and mitochondrial fatty acid metabolizing enzymes revealed that both hPPAR alpha and mPPAR alpha were functional. However, the incidence of liver tumors including hepatocellular carcinoma was 71% in Wy-14,643-treated mPPAR alpha mice, and 5% in Wy-14,643-treated hPPAR alpha mice. Upregulation of cell cycle regulated genes such as cd1 and Cdks were observed in non-tumorous liver tissue of Wy-14,643-treated mPPAR alpha mice, whereas p53 gene expression was increased only in the livers of Wy-14,643-treated hPPAR alpha mice. These findings suggest that structural differences between human and mouse PPAR alpha are responsible for the differential susceptibility to the peroxisome proliferator-induced hepatocarcinogenesis. This mouse model will be useful for human cancer risk assessment of PPAR alpha ligands. JF - Carcinogenesis AU - Morimura, Keiichirou AU - Cheung, Connie AU - Ward, Jerrold M AU - Reddy, Janardan K AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA and Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1074 EP - 1080 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 5 SN - 0143-3334, 0143-3334 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Diets KW - Peroxisome proliferator-activated receptors KW - Cell cycle KW - Tumorigenesis KW - Animal models KW - Enzymes KW - Mitochondria KW - p53 protein KW - Gene expression KW - Cyclin-dependent kinase KW - Carcinogenesis KW - Fatty acids KW - Drugs KW - Hepatocellular carcinoma KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19441758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Differential+susceptibility+of+mice+humanized+for+peroxisome+proliferator-activated+receptor+alpha+to+Wy-14%2C643-induced+liver+tumorigenesis&rft.au=Morimura%2C+Keiichirou%3BCheung%2C+Connie%3BWard%2C+Jerrold+M%3BReddy%2C+Janardan+K%3BGonzalez%2C+Frank+J&rft.aulast=Morimura&rft.aufirst=Keiichirou&rft.date=2006-05-01&rft.volume=27&rft.issue=5&rft.spage=1074&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Peroxisome proliferator-activated receptors; Tumorigenesis; Gene expression; Fatty acids; p53 protein; Diets; Carcinogenesis; Risk assessment; Animal models; Mitochondria; Cell cycle; Enzymes; Cyclin-dependent kinase; Hepatocellular carcinoma; Drugs ER - TY - JOUR T1 - Coincident filarial, intestinal helminth, and mycobacterial infection: Helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence AN - 19354328; 7110857 AB - The prevalence of helminth and tuberculosis infections is high in South India, whereas Bacille-Calmette-Guerin (BCG) vaccine efficacy is low. Our aim was to determine whether concurrent helminth infection alters the ability to mount a delayed-type hypersensitivity response to tuberculin. In a cross-sectional study in southern India, individuals 6-65 years of age were screened for intestinal helminths, circulating filarial antigenemia, tuberculin reactivity, active tuberculosis, and history of BCG vaccination; 54% were purified protein derivative (PPD) positive, 32% had intestinal helminth infection, 9% were circulating filarial antigen positive, and 0.5% had culture-confirmed active tuberculosis. Only age and BCG vaccination were significantly associated with PPD reactivity; however, BCG vaccination was associated with a lower prevalence of hookworm infection relative to those without prior BCG vaccination. Neither intestinal helminth infection nor filarial infection was associated with diminished frequencies of PPD positivity. Our findings suggest that preceding helminth infection does not influence significantly the delayed-type hypersensitivity response to tuberculin. JF - American Journal of Tropical Medicine and Hygiene AU - Lipner, E M AU - Gopi, P G AU - Subramani, R AU - Kolappan, C AU - Sadacharam, K AU - Kumaran, P AU - Prevots AU - Narayanan, PR AU - Nutman, T B AU - Kumaraswami, V AD - LPD, NIAID, 4 Center Drive, Room 4/126, NIH, Bethesda, MD 20892, USA, tnutman@niaid.nih.gov Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 841 EP - 847 VL - 74 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology KW - Hypersensitivity (delayed) KW - BCG KW - Intestine KW - Tuberculin KW - Tuberculosis KW - Vaccines KW - Antigenemia KW - Infection KW - Vaccination KW - India KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19354328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Coincident+filarial%2C+intestinal+helminth%2C+and+mycobacterial+infection%3A+Helminths+fail+to+influence+tuberculin+reactivity%2C+but+BCG+influences+hookworm+prevalence&rft.au=Lipner%2C+E+M%3BGopi%2C+P+G%3BSubramani%2C+R%3BKolappan%2C+C%3BSadacharam%2C+K%3BKumaran%2C+P%3BPrevots%3BNarayanan%2C+PR%3BNutman%2C+T+B%3BKumaraswami%2C+V&rft.aulast=Lipner&rft.aufirst=E&rft.date=2006-05-01&rft.volume=74&rft.issue=5&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hypersensitivity (delayed); BCG; Intestine; Tuberculosis; Tuberculin; Antigenemia; Vaccines; Infection; Vaccination; India ER - TY - JOUR T1 - Ethanol inhibits brain-derived neurotrophic factor stimulation of extracellular signal-regulated/mitogen-activated protein kinase in cerebellar granule cells AN - 19306539; 7040753 AB - Brain-derived neurotrophic factor (BDNF) has emerged as a prominent mediator of neuronal development and synaptic plasticity. BDNF activates multiple signal transduction cascades that regulate cellular function through phosphorylation, transcription, and translation. Ethanol is known to inhibit neurotrophin signaling, but a thorough pharmacological analysis of the effect of ethanol on BDNF signaling in developing neurons has not been performed. These experiments were undertaken to determine the interactions between membrane depolarization, BDNF concentration, and ethanol concentration on extracellular signal-regulated protein kinase (ERK) activation in neurons. We examined cerebellar granule cells grown under physiological (5 mM) or elevated (25 mM) potassium culture conditions after 3 days in vitro. BDNF-stimulated ERK phosphorylation (pERK) within 10 min and supported stimulation from 20 to 60 min. Ethanol decreased basal pERK and reduced the magnitude of BDNF stimulation of ERK under both conditions. The NMDA receptor antagonist 2-amino-5-phosphonovalerate did not effect basal pERK or inhibit BDNF stimulation of ERK, suggesting that NMDA receptors do not modulate BDNF stimulation of ERK in short-term cultures. These data characterize the pharmacological effects of ethanol on growth factor signaling and provide the basis of a model for further characterization of the biochemical mechanisms of ERK inhibition by ethanol. Perturbation of BDNF signal transduction by ethanol may underlie some of the cognitive deficits and developmental abnormalities resulting from ethanol exposure. JF - Alcohol AU - Ohrtman, Joshua D AU - Stancik, Elizabeth K AU - Lovinger, David M AU - Davis, Margaret I AD - Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9411, Bethesda, MD 20892-9411, USA, midavis@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 29 EP - 37 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 39 IS - 1 SN - 0741-8329, 0741-8329 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Ethanol KW - Brain-derived neurotrophic factor KW - Extracellular signal-regulated kinase KW - Development KW - NMDA KW - Translation KW - MAP kinase KW - N-Methyl-D-aspartic acid receptors KW - Neurotrophins KW - Cerebellum KW - Transcription KW - Potassium KW - Cell culture KW - Plasticity (synaptic) KW - Glutamic acid receptors KW - Granule cells KW - Phosphorylation KW - Cognitive ability KW - Synaptogenesis KW - Neurons KW - Protein kinase KW - Growth factors KW - Depolarization KW - Signal transduction KW - Membrane potential KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19306539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Ethanol+inhibits+brain-derived+neurotrophic+factor+stimulation+of+extracellular+signal-regulated%2Fmitogen-activated+protein+kinase+in+cerebellar+granule+cells&rft.au=Ohrtman%2C+Joshua+D%3BStancik%2C+Elizabeth+K%3BLovinger%2C+David+M%3BDavis%2C+Margaret+I&rft.aulast=Ohrtman&rft.aufirst=Joshua&rft.date=2006-05-01&rft.volume=39&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2006.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Translation; N-Methyl-D-aspartic acid receptors; MAP kinase; Neurotrophins; Cerebellum; Potassium; Transcription; Cell culture; Plasticity (synaptic); Glutamic acid receptors; Granule cells; Extracellular signal-regulated kinase; Phosphorylation; Synaptogenesis; Cognitive ability; Neurons; Protein kinase; Growth factors; Membrane potential; Ethanol; Signal transduction; Depolarization DO - http://dx.doi.org/10.1016/j.alcohol.2006.06.011 ER - TY - JOUR T1 - Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions AN - 17233468; 6969052 AB - Both cholecystokinin (CCK) antagonists and N-methyl-d-aspartate (NMDA) antagonists block or reduce the development of morphine tolerance in several analgesic assays. The present experiments were performed to assess the ability of the CCK antagonist proglumide and the NMDA antagonist MK-801 to affect tolerance to the aversive properties of morphine as indexed by conditioned taste aversion (CTA) learning. Specifically, male Sprague-Dawley rats were exposed to either vehicle or morphine (5 mg/kg) in combination with either proglumide (5 mg/kg; Experiment 1), MK-801 (0.1 mg/kg; Experiment 2) or naloxone (1, 3.2 mg/kg; Experiment 3). Saccharin was then presented and was followed by an injection of either vehicle or morphine (10 mg/kg). Animals preexposed to and conditioned with morphine acquired an attenuated morphine-induced aversion to saccharin. While neither proglumide nor MK-801 had an effect on this attenuation, naloxone blocked the effects of morphine preexposure, suggesting that neither CCK nor NMDA may be involved in the aversive effects of morphine (or their modulation by drug exposure). That the attenuating effects of morphine preexposure on a morphine-induced CTA can be blocked suggests that the weakening of the aversive effects of morphine with chronic use can be prevented, an effect that may have implications for overall drug acceptability. JF - Pharmacology Biochemistry and Behavior AU - Fox, Meredith A AU - Stevenson, Glenn W AU - Rice, Kenner C AU - Riley, Anthony L AD - Laboratory of Clinical Science, Building 10, Room 3D41 National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, mfox@mail.nih.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 169 EP - 177 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 84 IS - 1 SN - 0091-3057, 0091-3057 KW - CSA Neurosciences Abstracts; Chemoreception Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Taste aversion KW - UCS preexposure KW - Tolerance KW - Morphine KW - Proglumide KW - MK-801 KW - Naloxone KW - NMDA KW - CCK KW - Saccharin KW - N-Methyl-D-aspartic acid receptors KW - Taste discrimination learning KW - Cholecystokinin KW - Drug tolerance KW - Glutamic acid receptors KW - Antagonists KW - Aversion KW - Taste aversion learning KW - Analgesics KW - N-Methyl-D-aspartic acid KW - Drugs KW - X 24380:Social Poisons & Drug Abuse KW - R 18058:Learning & conditioning KW - Y 25817:Mammals (excluding primates) KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17233468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Naloxone%2C+not+proglumide+or+MK-801%2C+alters+effects+of+morphine+preexposure+on+morphine-induced+taste+aversions&rft.au=Fox%2C+Meredith+A%3BStevenson%2C+Glenn+W%3BRice%2C+Kenner+C%3BRiley%2C+Anthony+L&rft.aulast=Fox&rft.aufirst=Meredith&rft.date=2006-05-01&rft.volume=84&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2006.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Morphine; N-Methyl-D-aspartic acid receptors; Saccharin; Taste discrimination learning; Cholecystokinin; Drug tolerance; Glutamic acid receptors; MK-801; Antagonists; Naloxone; Aversion; Taste aversion; Taste aversion learning; Analgesics; N-Methyl-D-aspartic acid; Drugs DO - http://dx.doi.org/10.1016/j.pbb.2006.05.003 ER - TY - JOUR T1 - Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils AN - 17206248; 6779609 AB - The spirochaetes that cause tick-borne relapsing fever and Lyme disease are closely related human pathogens, yet they differ significantly in their ecology and pathogenicity. Genome sequencing of two species of relapsing fever spirochaetes, Borrelia hermsii and Borrelia turicatae, identified a chromosomal open reading frame, designated bhpA, not present in the Lyme disease spirochaete Borrelia burgdorferi. The predicted amino acid sequence of bhpA was homologous with the HtrA serine proteases, which are involved with stress responses and virulence in other bacteria. B. hermsii produced an active serine protease that was recognized by BhpA antibodies and the recombinant BhpA protein-degraded beta -casein. bhpA was transcribed in vitro at all growth temperatures and transcription levels were slightly elevated at higher temperatures. These results correlated with the synthesis of BhpA during B. hermsii infection in mice. With the exception of Borrelia recurrentis, the bhpA gene, protein and enzymatic activity were found in all relapsing fever spirochaetes, but not in Lyme disease or related spirochaetes. Heterologous expression of bhpA in B. burgdorferi increased the spirochaete's resistance to both oxidative stress and killing by human neutrophils. Therefore, we propose that bhpA encodes a unique and functional serine protease in relapsing fever spirochaetes. This periplasmic enzyme may prevent the accumulation of proteins damaged by the innate immune response and contribute to the ability of the relapsing fever spirochaetes to achieve high cell densities in blood. JF - Molecular Microbiology AU - Guyard, Cyril AU - Battisti, James M AU - Raffel, Sandra J AU - Schrumpf, Merry E AU - Whitney, Adeline R AU - Krum, Jonathan G AU - Porcella, Stephen F AU - Rosa, Patricia A AU - DeLeo, Frank R AU - Schwan, Tom G Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 710 EP - 722 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 60 IS - 3 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Borrelia hermsii KW - Relapsing fever KW - Cell density KW - Virulence KW - Borrelia recurrentis KW - Pathogenicity KW - Oxidative stress KW - Enzymatic activity KW - Lyme disease KW - Temperature effects KW - tick-borne relapsing fever KW - Serine proteinase KW - Borrelia burgdorferi KW - Leukocytes (neutrophilic) KW - Enzymes KW - Transcription KW - Pathogens KW - Borrelia turicatae KW - Casein KW - Blood KW - Antibodies KW - Immune response KW - Open reading frames KW - Amino acid sequence KW - J 02855:Human Bacteriology: Others KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17206248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Relapsing+fever+spirochaetes+produce+a+serine+protease+that+provides+resistance+to+oxidative+stress+and+killing+by+neutrophils&rft.au=Guyard%2C+Cyril%3BBattisti%2C+James+M%3BRaffel%2C+Sandra+J%3BSchrumpf%2C+Merry+E%3BWhitney%2C+Adeline+R%3BKrum%2C+Jonathan+G%3BPorcella%2C+Stephen+F%3BRosa%2C+Patricia+A%3BDeLeo%2C+Frank+R%3BSchwan%2C+Tom+G&rft.aulast=Guyard&rft.aufirst=Cyril&rft.date=2006-05-01&rft.volume=60&rft.issue=3&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05122.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - SuppNotes - Figures, 8; tables, 3; references, 60. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Temperature effects; tick-borne relapsing fever; Serine proteinase; Relapsing fever; Cell density; Leukocytes (neutrophilic); Transcription; Enzymes; Pathogens; Casein; Virulence; Blood; Antibodies; Pathogenicity; Oxidative stress; Enzymatic activity; Immune response; Open reading frames; Lyme disease; Amino acid sequence; Borrelia recurrentis; Borrelia hermsii; Borrelia burgdorferi; Borrelia turicatae DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05122.x ER - TY - JOUR T1 - Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant AN - 17162479; 6811436 AB - The promising, but modest, clinical results of many human cancer vaccines indicate a need for vaccine adjuvants that can increase both the quantity and the quality of vaccine-induced, tumor-specific T cells. In this study we tested the immunological and antitumor effects of the proinflammatory cytokine, IL-23, in gp100 peptide vaccine therapy of established murine melanoma. Neither systemic nor local IL-23 alone had any impact on tumor growth or tumor-specific T cell numbers. Upon specific vaccination, however, systemic IL-23 greatly increased the relative and absolute numbers of vaccine-induced CD8 super(+) T cells and enhanced their effector function at the tumor site. Although IL-23 specifically increased IFN- gamma production by tumor-specific T cells, IFN- gamma itself was not a primary mediator of the vaccine adjuvant effect. The IL-23-induced antitumor effect and accompanying reversible weight loss were both partially mediated by TNF- alpha . In contrast, local expression of IL-23 at the tumor site maintained antitumor activity in the absence of weight loss. Under these conditions, it was also clear that enhanced effector function of vaccine-induced CD8 super(+) T cells, rather than increased T cell number, is a primary mechanism underlying the antitumor effect of IL-23. Collectively, these results suggest that IL-23 is a potent vaccine adjuvant for the induction of therapeutic, tumor-specific CD8 super(+) T cell responses. JF - Journal of Immunology AU - Overwijk, Willem W AU - de Visser, Karin E AU - Tirion, Felicia H AU - de Jong, Laurina A AU - Pols, Thijs WH AU - van der Velden, Yme U AU - van den Boorn, Jasper G AU - Keller, Anna M AU - Buurman, Wim A AU - Theoret, Marc R AU - Blom, Bianca AU - Restifo, Nicholas P AU - Kruisbeek, Ada M AU - Kastelein, Robert A AU - Haanen, John BAG AD - Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Department of General Surgery, University Maastricht, Maastricht, The Netherlands. National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. DNAX Research Institute, Palo Alto, CA 93404 Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 5213 EP - 5222 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 9 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Cancer vaccines KW - Adjuvants KW - Melanoma KW - Glycoprotein gp100 KW - Lymphocytes T KW - g-Interferon KW - Therapy KW - CD8 antigen KW - Tumor necrosis factor-a KW - Inflammation KW - Interleukin 23 KW - ^g-Interferon KW - Tumor necrosis factor-^a KW - Antitumor activity KW - W3 33350:Cancer vaccines KW - F 06150:Immunotherapy KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17162479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Immunological+and+Antitumor+Effects+of+IL-23+as+a+Cancer+Vaccine+Adjuvant&rft.au=Overwijk%2C+Willem+W%3Bde+Visser%2C+Karin+E%3BTirion%2C+Felicia+H%3Bde+Jong%2C+Laurina+A%3BPols%2C+Thijs+WH%3Bvan+der+Velden%2C+Yme+U%3Bvan+den+Boorn%2C+Jasper+G%3BKeller%2C+Anna+M%3BBuurman%2C+Wim+A%3BTheoret%2C+Marc+R%3BBlom%2C+Bianca%3BRestifo%2C+Nicholas+P%3BKruisbeek%2C+Ada+M%3BKastelein%2C+Robert+A%3BHaanen%2C+John+BAG&rft.aulast=Overwijk&rft.aufirst=Willem&rft.date=2006-05-01&rft.volume=176&rft.issue=9&rft.spage=5213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adjuvants; Interleukin 23; Lymphocytes T; Therapy; CD8 antigen; g-Interferon; Cancer vaccines; Tumor necrosis factor-a; Antitumor activity; Inflammation; Glycoprotein gp100; Melanoma; ^g-Interferon; Tumor necrosis factor-^a ER - TY - JOUR T1 - Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice AN - 17150159; 6810471 AB - Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice. JF - Infection and Immunity AU - Parveen, Nikhat AU - Cornell, Kenneth A AU - Bono, James L AU - Chamberland, Christen AU - Rosa, Patricia AU - Leong, John M AD - Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, ICPH Building, Newark, New Jersey 07103-2714. Department of Chemistry, Boise State University, 1910 University Drive, Boise, Idaho 83725-1520. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3016 EP - 3020 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 5 SN - 0019-9567, 0019-9567 KW - Nucleosidase KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Colonization KW - Spirochetes KW - Glycosaminoglycans KW - Borrelia burgdorferi KW - Immunodeficiency KW - Severe combined immunodeficiency KW - Plasmids KW - Lyme disease KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17150159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Bgp%2C+a+Secreted+Glycosaminoglycan-Binding+Protein+of+Borrelia+burgdorferi+Strain+N40%2C+Displays+Nucleosidase+Activity+and+Is+Not+Essential+for+Infection+of+Immunodeficient+Mice&rft.au=Parveen%2C+Nikhat%3BCornell%2C+Kenneth+A%3BBono%2C+James+L%3BChamberland%2C+Christen%3BRosa%2C+Patricia%3BLeong%2C+John+M&rft.aulast=Parveen&rft.aufirst=Nikhat&rft.date=2006-05-01&rft.volume=74&rft.issue=5&rft.spage=3016&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Spirochetes; Colonization; Glycosaminoglycans; Immunodeficiency; Severe combined immunodeficiency; Plasmids; Lyme disease; Borrelia burgdorferi ER - TY - JOUR T1 - Adenosine A sub(2A) Receptor Inactivation Increases Survival in Polymicrobial Sepsis AN - 17147500; 6811481 AB - The mechanisms governing the impairment of bacterial clearance and immune function in sepsis are not known. Adenosine levels are elevated during tissue hypoxia and damage associated with sepsis. Adenosine has strong immunosuppressive effects, many of which are mediated by A sub(2A) receptors (A sub(2A)R) expressed on immune cells. We examined whether A sub(2A)R are involved in the regulation of immune function in cecal ligation and puncture-induced murine polymicrobial sepsis by genetically or pharmacologically inactivating A sub(2A)R. A sub(2A)R knockout (KO) mice were protected from the lethal effect of sepsis and had improved bacterial clearance compared with wild-type animals. cDNA microarray analysis and flow cytometry revealed increased MHC II expression in A sub(2A)-inactivated mice, suggesting improved Ag presentation as a mechanism of protection. Apoptosis was attenuated in the spleen of A sub(2A) KO mice indicating preserved lymphocyte function. Levels of the immunosuppressive cytokines IL-10 and IL-6 were markedly lower following A sub(2A)R blockade. Similar to observations with A sub(2A)R KO mice, an A sub(2A)R antagonist increased survival even when administered in a delayed fashion. These studies demonstrate that A sub(2A)R blockade may be useful in the treatment of infection and sepsis. JF - Journal of Immunology AU - Nemeth, Zoltan H AU - Csoka, Balazs AU - Wilmanski, Jeanette AU - Xu, DaZhong AU - Lu, Qi AU - Ledent, Catherine AU - Deitch, Edwin A AU - Pacher, Pal AU - Spolarics, Zoltan AU - Hasko, Gyoergy AD - Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103. Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Universite Libre de Bruxelles, Brussels, Belgium. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 5616 EP - 5626 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 9 SN - 0022-1767, 0022-1767 KW - Ad2A receptors KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Apoptosis KW - Adenosine receptors KW - Animal models KW - Major histocompatibility complex KW - Lymphocytes KW - Transgenic mice KW - Infection KW - Cytometry KW - Interleukin 10 KW - Sepsis KW - Hypoxia KW - Cytokines KW - Cecum KW - Antigen-presenting cells KW - Immunosuppression KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Adenosine+A+sub%282A%29+Receptor+Inactivation+Increases+Survival+in+Polymicrobial+Sepsis&rft.au=Nemeth%2C+Zoltan+H%3BCsoka%2C+Balazs%3BWilmanski%2C+Jeanette%3BXu%2C+DaZhong%3BLu%2C+Qi%3BLedent%2C+Catherine%3BDeitch%2C+Edwin+A%3BPacher%2C+Pal%3BSpolarics%2C+Zoltan%3BHasko%2C+Gyoergy&rft.aulast=Nemeth&rft.aufirst=Zoltan&rft.date=2006-05-01&rft.volume=176&rft.issue=9&rft.spage=5616&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Apoptosis; Adenosine receptors; Animal models; Major histocompatibility complex; Lymphocytes; Infection; Transgenic mice; Interleukin 10; Cytometry; Sepsis; Hypoxia; Cecum; Cytokines; Antigen-presenting cells; Immunosuppression ER - TY - CPAPER T1 - Secondary Lens Fiber Cell Disintegration in aA-/aB-Crystallin Double Knockout Mice - The Role of Caspases T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40050743; 4200366 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Wawrousek, E F AU - Morozov, V Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mice KW - Fibers KW - Caspase KW - A-crystallin KW - Eye lens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40050743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Secondary+Lens+Fiber+Cell+Disintegration+in+aA-%2FaB-Crystallin+Double+Knockout+Mice+-+The+Role+of+Caspases&rft.au=Wawrousek%2C+E+F%3BMorozov%2C+V&rft.aulast=Wawrousek&rft.aufirst=E&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Migration of CD4+ T Cells and Inflammation Onset are Controlled by SOCS1 T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40050723; 4199944 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Yu, C. AU - Mahdi, R M AU - Liu, X AU - Takase, H AU - Zhang, A AU - Amadi-Obi, A I AU - Egwuagu, C E Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Lymphocytes T KW - CD4 antigen KW - Cell migration KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40050723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Migration+of+CD4%2B+T+Cells+and+Inflammation+Onset+are+Controlled+by+SOCS1&rft.au=Yu%2C+C.%3BMahdi%2C+R+M%3BLiu%2C+X%3BTakase%2C+H%3BZhang%2C+A%3BAmadi-Obi%2C+A+I%3BEgwuagu%2C+C+E&rft.aulast=Yu&rft.aufirst=C.&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hyporeactive Ocular Responses to Lipopolysaccharide in CCL2/CX3CR1 Double Deficient Mice T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40050034; 4199928 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Shen, D AU - Tuo, J AU - Bojanowski, C M AU - Zhou, M AU - Ross, R J AU - Chan, C.-C. Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mice KW - CX3CR1 protein KW - CCL2 protein KW - Lipopolysaccharides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40050034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Hyporeactive+Ocular+Responses+to+Lipopolysaccharide+in+CCL2%2FCX3CR1+Double+Deficient+Mice&rft.au=Shen%2C+D%3BTuo%2C+J%3BBojanowski%2C+C+M%3BZhou%2C+M%3BRoss%2C+R+J%3BChan%2C+C.-C.&rft.aulast=Shen&rft.aufirst=D&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pathology of Lens of Perlecan Rescued Mice T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40046891; 4201942 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Masuda, I AU - Takada, Y AU - Igarashi, T AU - Kang, F AU - Fukushi, M AU - Hasegawa, T AU - Yamada, Y AU - Csaky, K G Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mice KW - Pathology KW - Eye lens KW - Perlecan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40046891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=The+Pathology+of+Lens+of+Perlecan+Rescued+Mice&rft.au=Masuda%2C+I%3BTakada%2C+Y%3BIgarashi%2C+T%3BKang%2C+F%3BFukushi%2C+M%3BHasegawa%2C+T%3BYamada%2C+Y%3BCsaky%2C+K+G&rft.aulast=Masuda&rft.aufirst=I&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Mutation (Arg413Ter) in the BBS2 Gene in a Consanguineous Pakistani Family with Bardet-Biedl Syndrome T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40046010; 4200939 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Kordestani, L Amiri AU - Yao, W AU - Zulfiqar, F AU - Riazuddin,A. AU - Zhang, Q AU - Amer, M AU - Hussnain, T AU - Sieving, P A AU - Riazuddin, S AU - Hejtmancik, J F Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mutation KW - Bardet-Biedl syndrome KW - BBS2 gene KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40046010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=A+Novel+Mutation+%28Arg413Ter%29+in+the+BBS2+Gene+in+a+Consanguineous+Pakistani+Family+with+Bardet-Biedl+Syndrome&rft.au=Kordestani%2C+L+Amiri%3BYao%2C+W%3BZulfiqar%2C+F%3BRiazuddin%2CA.%3BZhang%2C+Q%3BAmer%2C+M%3BHussnain%2C+T%3BSieving%2C+P+A%3BRiazuddin%2C+S%3BHejtmancik%2C+J+F&rft.aulast=Kordestani&rft.aufirst=L&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Corneal Cells Release IL-6 When Treated with Immune Complex (HSV-1-Human IgG) or Transfected with HSV-DNA T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40043678; 4202359 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Hayashi, K AU - Hooper, L C AU - Chin, M S AU - Nagineni, C N AU - Detrick, B AU - Hooks, J J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Antigen-antibody complexes KW - Immunoglobulin G KW - Interleukin 6 KW - Cornea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40043678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Corneal+Cells+Release+IL-6+When+Treated+with+Immune+Complex+%28HSV-1-Human+IgG%29+or+Transfected+with+HSV-DNA&rft.au=Hayashi%2C+K%3BHooper%2C+L+C%3BChin%2C+M+S%3BNagineni%2C+C+N%3BDetrick%2C+B%3BHooks%2C+J+J&rft.aulast=Hayashi&rft.aufirst=K&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical and Molecular Characterization of Ocular Involvement in Von-Hippel-Lindau (VHL) Disease T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40042807; 4201010 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Wong, W T AU - Agron, E AU - Coleman, H R AU - Reed, G AU - Csaky, K AU - Glenn, G AU - Linehan, W M AU - Albert, P AU - Chew, E Y Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - VHL protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40042807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Clinical+and+Molecular+Characterization+of+Ocular+Involvement+in+Von-Hippel-Lindau+%28VHL%29+Disease&rft.au=Wong%2C+W+T%3BAgron%2C+E%3BColeman%2C+H+R%3BReed%2C+G%3BCsaky%2C+K%3BGlenn%2C+G%3BLinehan%2C+W+M%3BAlbert%2C+P%3BChew%2C+E+Y&rft.aulast=Wong&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype-Phenotype Correlations of R245X of PCDH15 Encoding Protocadherin-15 T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40041393; 4201365 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Tsilou, E T AU - Schultz, J AU - Meltzer, M AU - Caruso, R C AU - Griffith, A AU - Madeo, A AU - Brewer, C AU - Zalewski, C AU - Reed, G AU - Friedman, T Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Surgery KW - Genetics KW - Pediatrics KW - Retina UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40041393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Genotype-Phenotype+Correlations+of+R245X+of+PCDH15+Encoding+Protocadherin-15&rft.au=Tsilou%2C+E+T%3BSchultz%2C+J%3BMeltzer%2C+M%3BCaruso%2C+R+C%3BGriffith%2C+A%3BMadeo%2C+A%3BBrewer%2C+C%3BZalewski%2C+C%3BReed%2C+G%3BFriedman%2C+T&rft.aulast=Tsilou&rft.aufirst=E&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Age-Related Maculopathy in an Elderly Chinese Population in Taiwan: The Shihpai Eye Study T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40041090; 4201688 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Cheng, C.-Y. AU - Chen, S.-J. AU - Tsai, H.-Y. AU - Hsu, W.-M. AU - Liu, J.-H. AU - Chou, P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Taiwan KW - Elderly KW - Eye KW - Geriatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40041090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Prevalence+of+Age-Related+Maculopathy+in+an+Elderly+Chinese+Population+in+Taiwan%3A+The+Shihpai+Eye+Study&rft.au=Cheng%2C+C.-Y.%3BChen%2C+S.-J.%3BTsai%2C+H.-Y.%3BHsu%2C+W.-M.%3BLiu%2C+J.-H.%3BChou%2C+P&rft.aulast=Cheng&rft.aufirst=C.-Y.&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Cytokines Alter Polarized Chemokine Secretion and Fluid Transport by Human Fetal RPE In Vitro T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40040381; 4201542 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Shi, G AU - Jalickee, S AU - Banzon, T AU - Hammer, J AU - Maminishkis, A AU - Miller, S S Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Cytokines KW - Fetuses KW - Chemokines KW - Inflammation KW - Secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Inflammatory+Cytokines+Alter+Polarized+Chemokine+Secretion+and+Fluid+Transport+by+Human+Fetal+RPE+In+Vitro&rft.au=Shi%2C+G%3BJalickee%2C+S%3BBanzon%2C+T%3BHammer%2C+J%3BMaminishkis%2C+A%3BMiller%2C+S+S&rft.aulast=Shi&rft.aufirst=G&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HTLV-1 Infection of Human Retinal Pigment Epithelial Cells and Inhibition of Viral Infection by an Antibody to ICAM-1 T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40040046; 4202363 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Liu, B AU - Li, Z. AU - Mahesh, S AU - Kurup, S AU - Giam, C.-Z. AU - Nussenblatt, R Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Infection KW - Pigments KW - Retinal pigment epithelium KW - Antibodies KW - Intercellular adhesion molecule 1 KW - Viral diseases KW - Human T-lymphotropic virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=HTLV-1+Infection+of+Human+Retinal+Pigment+Epithelial+Cells+and+Inhibition+of+Viral+Infection+by+an+Antibody+to+ICAM-1&rft.au=Liu%2C+B%3BLi%2C+Z.%3BMahesh%2C+S%3BKurup%2C+S%3BGiam%2C+C.-Z.%3BNussenblatt%2C+R&rft.aulast=Liu&rft.aufirst=B&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Cytokines and Specific Platelet Derived Growth Factors (PDGF) Alter Human Fetal Retinal Pigment Epithelia (hfRPE) Migration and Proliferation T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40039580; 4202231 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Li, R. AU - Maminishkis, A AU - Wang, F E AU - Miller, S S Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Migration KW - Growth factors KW - Cytokines KW - Platelets KW - Fetuses KW - Platelet-derived growth factor KW - Inflammation KW - Epithelia KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40039580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Inflammatory+Cytokines+and+Specific+Platelet+Derived+Growth+Factors+%28PDGF%29+Alter+Human+Fetal+Retinal+Pigment+Epithelia+%28hfRPE%29+Migration+and+Proliferation&rft.au=Li%2C+R.%3BMaminishkis%2C+A%3BWang%2C+F+E%3BMiller%2C+S+S&rft.aulast=Li&rft.aufirst=R.&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of a B1 and aB2 Crystallin in Zebrafish T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40037170; 4197945 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Dadon-Dahan, T AU - Spencer, M AU - Nevo, E AU - Piatigorsky, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Crystallin KW - Freshwater fish KW - Danio rerio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Differential+Expression+of+a+B1+and+aB2+Crystallin+in+Zebrafish&rft.au=Dadon-Dahan%2C+T%3BSpencer%2C+M%3BNevo%2C+E%3BPiatigorsky%2C+J&rft.aulast=Dadon-Dahan&rft.aufirst=T&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Complications of Sarcoidosis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40035183; 4197770 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Davuluri, G AU - Reed, G F AU - Smith, J A AU - Rubin, B AU - Nussenblatt, R B AU - Levy-Clarke, G A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Sarcoidosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40035183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Ocular+Complications+of+Sarcoidosis&rft.au=Davuluri%2C+G%3BReed%2C+G+F%3BSmith%2C+J+A%3BRubin%2C+B%3BNussenblatt%2C+R+B%3BLevy-Clarke%2C+G+A&rft.aulast=Davuluri&rft.aufirst=G&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiology and Course of Disease in Childhood Uveitis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40034029; 4201846 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Smith, J A AU - Mackensen, F AU - Smith, J R AU - Freidlin, J AU - Sen, N AU - Watkins, A AU - Tessler, H AU - Pyatesky, D AU - Nussenblatt, R AU - Goldstein, D A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Epidemiology KW - Uveitis KW - Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40034029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Epidemiology+and+Course+of+Disease+in+Childhood+Uveitis&rft.au=Smith%2C+J+A%3BMackensen%2C+F%3BSmith%2C+J+R%3BFreidlin%2C+J%3BSen%2C+N%3BWatkins%2C+A%3BTessler%2C+H%3BPyatesky%2C+D%3BNussenblatt%2C+R%3BGoldstein%2C+D+A&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Analysis of the Vimentin Gene in the Barbados Family Study of Open-Angle Glaucoma (BFSG) T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40033408; 4197383 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Chang, L AU - Jiao, X AU - Yao, W AU - Hejtmancik, J F AU - Leske, M C AU - Hennis, A AU - Nemesure, B Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Caribbean Sea, Lesser Antilles, Barbados KW - Glaucoma KW - Vimentin KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40033408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Molecular+Analysis+of+the+Vimentin+Gene+in+the+Barbados+Family+Study+of+Open-Angle+Glaucoma+%28BFSG%29&rft.au=Chang%2C+L%3BJiao%2C+X%3BYao%2C+W%3BHejtmancik%2C+J+F%3BLeske%2C+M+C%3BHennis%2C+A%3BNemesure%2C+B&rft.aulast=Chang&rft.aufirst=L&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-27 is Constitutively Expressed in the Retina and Up-Regulated during Experimental Autoimmune Uveitis (EAU) T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40031545; 4196850 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Amadi-Obi, A AU - Yu, C.-R. AU - Mahdi, R AU - Gery, I AU - Fariss, R N AU - Tsai, J Y AU - Egwuagu, C E Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Retina KW - Experimental autoimmune uveitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40031545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=IL-27+is+Constitutively+Expressed+in+the+Retina+and+Up-Regulated+during+Experimental+Autoimmune+Uveitis+%28EAU%29&rft.au=Amadi-Obi%2C+A%3BYu%2C+C.-R.%3BMahdi%2C+R%3BGery%2C+I%3BFariss%2C+R+N%3BTsai%2C+J+Y%3BEgwuagu%2C+C+E&rft.aulast=Amadi-Obi&rft.aufirst=A&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accumulation of Complement Components in Damaged Eyes T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40031512; 4200564 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Montalvo, V AU - Campos, M M AU - Wawrousek, E F AU - Bush, R A AU - Egwuagu, C E AU - Chan, C.-C. AU - Fariss, R N AU - Gery, I Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Complement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40031512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Accumulation+of+Complement+Components+in+Damaged+Eyes&rft.au=Montalvo%2C+V%3BCampos%2C+M+M%3BWawrousek%2C+E+F%3BBush%2C+R+A%3BEgwuagu%2C+C+E%3BChan%2C+C.-C.%3BFariss%2C+R+N%3BGery%2C+I&rft.aulast=Montalvo&rft.aufirst=V&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Macular Structure and Function in Stargardt Disease T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40029562; 4198818 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Caruso, R C AU - Short, G L AU - Lopez, P AU - Reuter, L M Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Structure-function relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40029562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Macular+Structure+and+Function+in+Stargardt+Disease&rft.au=Caruso%2C+R+C%3BShort%2C+G+L%3BLopez%2C+P%3BReuter%2C+L+M&rft.aulast=Caruso&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relation of Dynamic Light Scattering (DLS) Cataract Detection Device Parameters to Visual Acuity T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40026192; 4197048 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Vitale, S AU - Datiles, M B AU - Ansari, R R AU - Suh, K I AU - Reed, G F AU - King, J F AU - Ferris, F L Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Light scattering KW - Acuity KW - Cataracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40026192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Relation+of+Dynamic+Light+Scattering+%28DLS%29+Cataract+Detection+Device+Parameters+to+Visual+Acuity&rft.au=Vitale%2C+S%3BDatiles%2C+M+B%3BAnsari%2C+R+R%3BSuh%2C+K+I%3BReed%2C+G+F%3BKing%2C+J+F%3BFerris%2C+F+L&rft.aulast=Vitale&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heat-Induced Aggregation and Binding to a-Crystallin of Amino-Arm Truncated bA3-Crystallin T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40024819; 4200357 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Chan, M P AU - Sergeev, Y V AU - Wingfield, P T AU - Hejtmancik, J F Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - A-crystallin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40024819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Heat-Induced+Aggregation+and+Binding+to+a-Crystallin+of+Amino-Arm+Truncated+bA3-Crystallin&rft.au=Chan%2C+M+P%3BSergeev%2C+Y+V%3BWingfield%2C+P+T%3BHejtmancik%2C+J+F&rft.aulast=Chan&rft.aufirst=M&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduced ERG Amplitudes in the Absence of Retinal Degeneration in Deaf Ames Waltzer Mice T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40024038; 4199360 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Kjellstrom, S AU - Bush, R A AU - Haywood-Watson II, R.J.L. AU - Ahmed, Z M AU - Takada, Y AU - Friedman, T B AU - Sieving, P A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mice KW - Retinal degeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40024038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Reduced+ERG+Amplitudes+in+the+Absence+of+Retinal+Degeneration+in+Deaf+Ames+Waltzer+Mice&rft.au=Kjellstrom%2C+S%3BBush%2C+R+A%3BHaywood-Watson+II%2C+R.J.L.%3BAhmed%2C+Z+M%3BTakada%2C+Y%3BFriedman%2C+T+B%3BSieving%2C+P+A&rft.aulast=Kjellstrom&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Pathologic Retinal Neovascularization by a-Defensins T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40022693; 4199378 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Economopoulou, M AU - Bdeir, K AU - Cines, D B AU - Fogt, F AU - Bdeir, Y AU - Lubkowski, J AU - Hammes, H.-P. AU - Chavakis, T Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Vascularization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40022693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Inhibition+of+Pathologic+Retinal+Neovascularization+by+a-Defensins&rft.au=Economopoulou%2C+M%3BBdeir%2C+K%3BCines%2C+D+B%3BFogt%2C+F%3BBdeir%2C+Y%3BLubkowski%2C+J%3BHammes%2C+H.-P.%3BChavakis%2C+T&rft.aulast=Economopoulou&rft.aufirst=M&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD56@@u+@ CD3@@u+@CD8@@ubright@ Natural Killer T-Cells Appear to Correlate with Inflammatory Activity in Behcet's Disease T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40014532; 4199923 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Siu, W O AU - Li, Z. AU - Greenman, D B AU - Davuluri, G AU - Liu, B AU - Mahesh, S P AU - Levy-Clarke, G A AU - Nussenblatt, R B Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Lymphocytes T KW - Inflammation KW - CD56 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40014532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=CD56%40%40u%2B%40+CD3%40%40u%2B%40CD8%40%40ubright%40+Natural+Killer+T-Cells+Appear+to+Correlate+with+Inflammatory+Activity+in+Behcet%27s+Disease&rft.au=Siu%2C+W+O%3BLi%2C+Z.%3BGreenman%2C+D+B%3BDavuluri%2C+G%3BLiu%2C+B%3BMahesh%2C+S+P%3BLevy-Clarke%2C+G+A%3BNussenblatt%2C+R+B&rft.aulast=Siu&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Immune-Mediated Ocular Inflammation by Copolymers T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40009071; 4199954 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Yin, H AU - Vistica, B P AU - Chan, C.-C. AU - Wawrousek, E F AU - Gery, I Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Inflammation KW - Copolymers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Modulation+of+Immune-Mediated+Ocular+Inflammation+by+Copolymers&rft.au=Yin%2C+H%3BVistica%2C+B+P%3BChan%2C+C.-C.%3BWawrousek%2C+E+F%3BGery%2C+I&rft.aulast=Yin&rft.aufirst=H&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Lipids and Cataract in the Age-Related Eye Disease Study T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40007419; 4199606 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Lee, L B AU - SanGiovanni, J P AU - Chew, E Y AU - Agron, E AU - Reed, G F AU - Sperduto, R D AU - Clemons, T E AU - Seddon, J M Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Lipids KW - Eye diseases KW - Cataracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Dietary+Lipids+and+Cataract+in+the+Age-Related+Eye+Disease+Study&rft.au=Lee%2C+L+B%3BSanGiovanni%2C+J+P%3BChew%2C+E+Y%3BAgron%2C+E%3BReed%2C+G+F%3BSperduto%2C+R+D%3BClemons%2C+T+E%3BSeddon%2C+J+M&rft.aulast=Lee&rft.aufirst=L&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Transgenic Mouse Model of the Human γC-Crystallin 5bp Duplication Cataract T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40007311; 4199566 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Yao, W AU - Theendakara, V AU - Sergeev, Y AU - Crawford, M AU - Chan, C AU - Wawrousek, E AU - Hejtmancik, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Cataracts KW - Transgenic mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=A+Transgenic+Mouse+Model+of+the+Human+%CE%B3C-Crystallin+5bp+Duplication+Cataract&rft.au=Yao%2C+W%3BTheendakara%2C+V%3BSergeev%2C+Y%3BCrawford%2C+M%3BChan%2C+C%3BWawrousek%2C+E%3BHejtmancik%2C+J&rft.aulast=Yao&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NEI DNA Diagnostic Laboratory, Overview of the First Three Years T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40004695; 4200919 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Smaoui, N AU - Nwokekeh, N AU - Chang, L AU - Caruso, R C AU - Brooks, B P AU - Sieving, P A AU - Hejtmancik, J F Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=NEI+DNA+Diagnostic+Laboratory%2C+Overview+of+the+First+Three+Years&rft.au=Smaoui%2C+N%3BNwokekeh%2C+N%3BChang%2C+L%3BCaruso%2C+R+C%3BBrooks%2C+B+P%3BSieving%2C+P+A%3BHejtmancik%2C+J+F&rft.aulast=Smaoui&rft.aufirst=N&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Course of Rare Supratentorial Hemangioblastomas in von-Hippel Lindau Disease that Affect the Afferent Visual Pathway from the Retrobulbar Optic Nerve to the Optic Chiasm T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40003935; 4201026 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Jirawuthiworavong, G V AU - Dahr, S S AU - Wetjen, N M AU - Lonser, R R AU - Oldfield, E AU - Butman, J A AU - Coleman, H AU - Chew, E Y Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Optic nerve KW - Visual pathways KW - Optic chiasm KW - Nerves UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Clinical+Course+of+Rare+Supratentorial+Hemangioblastomas+in+von-Hippel+Lindau+Disease+that+Affect+the+Afferent+Visual+Pathway+from+the+Retrobulbar+Optic+Nerve+to+the+Optic+Chiasm&rft.au=Jirawuthiworavong%2C+G+V%3BDahr%2C+S+S%3BWetjen%2C+N+M%3BLonser%2C+R+R%3BOldfield%2C+E%3BButman%2C+J+A%3BColeman%2C+H%3BChew%2C+E+Y&rft.aulast=Jirawuthiworavong&rft.aufirst=G&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Lipid Intake and Vision Loss in the Age-Related Eye Disease Study T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40003727; 4201669 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - SanGiovanni, J P AU - Chew, E Y AU - Agron, E AU - Clemons, T E AU - Seddon, J M AU - Ferris, F L Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Vision KW - Lipids KW - Eye diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Dietary+Lipid+Intake+and+Vision+Loss+in+the+Age-Related+Eye+Disease+Study&rft.au=SanGiovanni%2C+J+P%3BChew%2C+E+Y%3BAgron%2C+E%3BClemons%2C+T+E%3BSeddon%2C+J+M%3BFerris%2C+F+L&rft.aulast=SanGiovanni&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Progression of Age-Related Macular Degeneration in African-Americans Enrolled in the Age-Related Eye Disease Study (AREDS), using the Areds Simple Scale T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40001008; 4196943 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Chew, E Y AU - Clemons, T AU - Lindblad, A AU - Ferris, F L AU - Klein, R Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Africa KW - Eye diseases KW - Macular degeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40001008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=The+Progression+of+Age-Related+Macular+Degeneration+in+African-Americans+Enrolled+in+the+Age-Related+Eye+Disease+Study+%28AREDS%29%2C+using+the+Areds+Simple+Scale&rft.au=Chew%2C+E+Y%3BClemons%2C+T%3BLindblad%2C+A%3BFerris%2C+F+L%3BKlein%2C+R&rft.aulast=Chew&rft.aufirst=E&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Murine Eye Development by Kruppel-Like Transcription Factor KLF4 T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40000342; 4202300 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Swamynathan, S K AU - Kaestner, K AU - Ashery-Padan, R AU - Piatigorsky, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Eye KW - Kruppel protein KW - KLF4 protein KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Regulation+of+Murine+Eye+Development+by+Kruppel-Like+Transcription+Factor+KLF4&rft.au=Swamynathan%2C+S+K%3BKaestner%2C+K%3BAshery-Padan%2C+R%3BPiatigorsky%2C+J&rft.aulast=Swamynathan&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profiles of Primary Human Fetal Retinal Pigment Epithelial (hfRPE) Cells Cultured on Flask and Transwell T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39994938; 4202209 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Wang, F AU - Zhi, C AU - Hammer, J AU - Maminishkis, A AU - Miller, S S Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Fetuses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Expression+Profiles+of+Primary+Human+Fetal+Retinal+Pigment+Epithelial+%28hfRPE%29+Cells+Cultured+on+Flask+and+Transwell&rft.au=Wang%2C+F%3BZhi%2C+C%3BHammer%2C+J%3BMaminishkis%2C+A%3BMiller%2C+S+S&rft.aulast=Wang&rft.aufirst=F&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Promise of Nanotechnology T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39994721; 4196739 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Sieving, P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=The+Promise+of+Nanotechnology&rft.au=Sieving%2C+P&rft.aulast=Sieving&rft.aufirst=P&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Haploinsufficiency is Not the Key Mechanism of Pathogenesis in a Heterozygous Elovl4 Knockout Mouse Model of STGD3 T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39992078; 4200835 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Raz, D AU - Ayyagari, R AU - Fariss, R N AU - Mandal, M A AU - Vasireddy, V AU - Webber, A L AU - Bush, R A AU - Salem Jr, N AU - Petrukhin, K AU - Sieving, P A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Haploinsufficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Haploinsufficiency+is+Not+the+Key+Mechanism+of+Pathogenesis+in+a+Heterozygous+Elovl4+Knockout+Mouse+Model+of+STGD3&rft.au=Raz%2C+D%3BAyyagari%2C+R%3BFariss%2C+R+N%3BMandal%2C+M+A%3BVasireddy%2C+V%3BWebber%2C+A+L%3BBush%2C+R+A%3BSalem+Jr%2C+N%3BPetrukhin%2C+K%3BSieving%2C+P+A&rft.aulast=Raz&rft.aufirst=D&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Models of Allergic Eye Disease T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39992072; 4196785 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Keane-Myers, A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Eye diseases KW - Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Mouse+Models+of+Allergic+Eye+Disease&rft.au=Keane-Myers%2C+A&rft.aulast=Keane-Myers&rft.aufirst=A&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - EST Analysis of Human Pterygium cDNA Library T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39991128; 4200401 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Jaworski, C J AU - John-Aryankalayil, M AU - Campos, M M AU - Fariss, R N AU - Rowsey, J AU - Reid, T W AU - Dushku, N AU - Cox, C AU - Wistow, G AU - Carper, D Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Expressed sequence tags KW - CDNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=EST+Analysis+of+Human+Pterygium+cDNA+Library&rft.au=Jaworski%2C+C+J%3BJohn-Aryankalayil%2C+M%3BCampos%2C+M+M%3BFariss%2C+R+N%3BRowsey%2C+J%3BReid%2C+T+W%3BDushku%2C+N%3BCox%2C+C%3BWistow%2C+G%3BCarper%2C+D&rft.aulast=Jaworski&rft.aufirst=C&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fenretinide Induced Neuronal Differentiation of ARPE-19 Cells is Associated with the Differential Expression of Pax-6, Tubulin b-III, Map-II, 14-3-3 and Bag-1 Proteins T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39989438; 4202225 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Chen, S AU - Fariss, R AU - Kutty, R K AU - Nelson, R AU - Wiggert, B Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Differentiation KW - Tubulin KW - Bag-1 protein KW - 14-3-3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39989438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Fenretinide+Induced+Neuronal+Differentiation+of+ARPE-19+Cells+is+Associated+with+the+Differential+Expression+of+Pax-6%2C+Tubulin+b-III%2C+Map-II%2C+14-3-3+and+Bag-1+Proteins&rft.au=Chen%2C+S%3BFariss%2C+R%3BKutty%2C+R+K%3BNelson%2C+R%3BWiggert%2C+B&rft.aulast=Chen&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primary Intraocular Lymphoma-A Descriptive Analysis of 2 Decades of Experience at the NEI T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39989237; 4202177 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Greenman, D B AU - Reed, G F AU - Mellow, S D AU - Nussenblatt, R B AU - Levy-Clarke, G A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Lymphoma KW - Retinoblastoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39989237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Primary+Intraocular+Lymphoma-A+Descriptive+Analysis+of+2+Decades+of+Experience+at+the+NEI&rft.au=Greenman%2C+D+B%3BReed%2C+G+F%3BMellow%2C+S+D%3BNussenblatt%2C+R+B%3BLevy-Clarke%2C+G+A&rft.aulast=Greenman&rft.aufirst=D&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and Characterization of Circulating Endothelial Progenitor Cells from Patients with Neovascular Age-Related Macular Degeneration T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39988828; 4196932 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Thill, M AU - Strunnikova, N V AU - Berna, M J AU - Ponce, L AU - Schmid, K AU - Csaky, K G Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Macular degeneration KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39988828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Isolation+and+Characterization+of+Circulating+Endothelial+Progenitor+Cells+from+Patients+with+Neovascular+Age-Related+Macular+Degeneration&rft.au=Thill%2C+M%3BStrunnikova%2C+N+V%3BBerna%2C+M+J%3BPonce%2C+L%3BSchmid%2C+K%3BCsaky%2C+K+G&rft.aulast=Thill&rft.aufirst=M&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Dietary Antioxidant Index and Risk for Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39984865; 4196520 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Rosenthal, J M AU - SanGiovanni, J P AU - Agron, E AU - Reed, G AU - Chew, E AU - Seddon, J AU - Ferris, F Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Eye diseases KW - Antioxidants KW - Macular degeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39984865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=A+Dietary+Antioxidant+Index+and+Risk+for+Advanced+Age-Related+Macular+Degeneration+in+the+Age-Related+Eye+Disease+Study&rft.au=Rosenthal%2C+J+M%3BSanGiovanni%2C+J+P%3BAgron%2C+E%3BReed%2C+G%3BChew%2C+E%3BSeddon%2C+J%3BFerris%2C+F&rft.aulast=Rosenthal&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Central Cornea Thickness is Increased in Patients with Ocular Coloboma T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39984014; 4200670 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Tang, J AU - Gokhale, P A AU - Brooks, S E AU - Blain, D AU - Brooks, B P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Cornea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39984014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Central+Cornea+Thickness+is+Increased+in+Patients+with+Ocular+Coloboma&rft.au=Tang%2C+J%3BGokhale%2C+P+A%3BBrooks%2C+S+E%3BBlain%2C+D%3BBrooks%2C+B+P&rft.aulast=Tang&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Doxycycline Effectively Inhibits Ocular Angiogenesis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39983618; 4199063 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Cox, C A AU - Amaral, J AU - Salloum, R AU - Garrick, A AU - Reid, T W AU - Jaworski, C AU - John-Aryankalayil, M AU - Freedman, K A AU - Becerra, S P AU - Carper, D A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Angiogenesis KW - Doxycycline UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Doxycycline+Effectively+Inhibits+Ocular+Angiogenesis&rft.au=Cox%2C+C+A%3BAmaral%2C+J%3BSalloum%2C+R%3BGarrick%2C+A%3BReid%2C+T+W%3BJaworski%2C+C%3BJohn-Aryankalayil%2C+M%3BFreedman%2C+K+A%3BBecerra%2C+S+P%3BCarper%2C+D+A&rft.aulast=Cox&rft.aufirst=C&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atypical Fundus Findings in X-Linked Retinoschisis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39977993; 4198813 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Fernandes, J K AU - Caruso, R C AU - Smaoui, N AU - Nwokekeh, N AU - Meltzer, M R AU - Hejtmancik, J F AU - Sieving, P A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Retinoschisis KW - X chromosome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Atypical+Fundus+Findings+in+X-Linked+Retinoschisis&rft.au=Fernandes%2C+J+K%3BCaruso%2C+R+C%3BSmaoui%2C+N%3BNwokekeh%2C+N%3BMeltzer%2C+M+R%3BHejtmancik%2C+J+F%3BSieving%2C+P+A&rft.aulast=Fernandes&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endotoxin-Induced Uveitis in Fat-1 Transgenic Mice T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39956385; 4199960 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Zhou, M AU - Shen, D AU - Tuo, J AU - Majchrzak, S AU - Loewke, J AU - Yu, C R AU - Salem Jr, N AU - Chan, C C Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mice KW - Uveitis KW - Transgenic mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Endotoxin-Induced+Uveitis+in+Fat-1+Transgenic+Mice&rft.au=Zhou%2C+M%3BShen%2C+D%3BTuo%2C+J%3BMajchrzak%2C+S%3BLoewke%2C+J%3BYu%2C+C+R%3BSalem+Jr%2C+N%3BChan%2C+C+C&rft.aulast=Zhou&rft.aufirst=M&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergetic Effect of a Functional Variation in ERCC6 5-Flanking Region and a Complement Factor H Variation Confers High Risk of Age-Related Macular Degeneration T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39954491; 4196844 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Tuo, J AU - Ning, B AU - Bojanowski1, C.M. AU - Lin, Z.-N. AU - Ross, R J AU - Reed, G AU - Shen, D AU - Jiao, X AU - Chew, E AU - Chan, C.-C. Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Complement factor H KW - Macular degeneration KW - Risk factors KW - Synergism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39954491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Synergetic+Effect+of+a+Functional+Variation+in+ERCC6+5-Flanking+Region+and+a+Complement+Factor+H+Variation+Confers+High+Risk+of+Age-Related+Macular+Degeneration&rft.au=Tuo%2C+J%3BNing%2C+B%3BBojanowski1%2C+C.M.%3BLin%2C+Z.-N.%3BRoss%2C+R+J%3BReed%2C+G%3BShen%2C+D%3BJiao%2C+X%3BChew%2C+E%3BChan%2C+C.-C.&rft.aulast=Tuo&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of Distinct SOCS Family Members in Insulin Resistance and Protection of Neuroretina T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39953389; 4199692 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Liu, X AU - Lee, Y AU - Tsai, J AU - Fariss, R AU - Yu, C. AU - Egwuagu, C E Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Insulin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39953389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Involvement+of+Distinct+SOCS+Family+Members+in+Insulin+Resistance+and+Protection+of+Neuroretina&rft.au=Liu%2C+X%3BLee%2C+Y%3BTsai%2C+J%3BFariss%2C+R%3BYu%2C+C.%3BEgwuagu%2C+C+E&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Gadd153 Gene Expression by Retinoic Acid Receptors in Human Retinal Pigment Epithelial (RPE) Cells during N-(4-Hydroxyphenyl)Retinamide Induced Apoptosis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39951232; 4201110 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Samuel, W AU - Kutty, R AU - Duncan, T AU - Wiggert, B Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Gene expression KW - Apoptosis KW - Retinoic acid receptors KW - CHOP protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39951232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Regulation+of+Gadd153+Gene+Expression+by+Retinoic+Acid+Receptors+in+Human+Retinal+Pigment+Epithelial+%28RPE%29+Cells+during+N-%284-Hydroxyphenyl%29Retinamide+Induced+Apoptosis&rft.au=Samuel%2C+W%3BKutty%2C+R%3BDuncan%2C+T%3BWiggert%2C+B&rft.aulast=Samuel&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression and Characterization of a Phospholipase-Linked Transmembrane Protein with Affinity for Pigment Epithelium-Derived Factor (PEDF) T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39950587; 4201500 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Heredia, R AU - Notari, L AU - Meyer, C AU - Balko, N AU - Becerra, S P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Pigment epithelium-derived factor KW - Membrane proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39950587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Expression+and+Characterization+of+a+Phospholipase-Linked+Transmembrane+Protein+with+Affinity+for+Pigment+Epithelium-Derived+Factor+%28PEDF%29&rft.au=Heredia%2C+R%3BNotari%2C+L%3BMeyer%2C+C%3BBalko%2C+N%3BBecerra%2C+S+P&rft.aulast=Heredia&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin D Receptor Agonists can Prevent and Treat Experimental Autoimmune Uveoretinitis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39948705; 4199953 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Zhu, W AU - Tang, J AU - Uskokovic, M R AU - Silver, P B AU - Su, S B AU - Chan, C.-C. AU - Adorini, L AU - Caspi, R R Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Uveoretinitis KW - Vitamin D receptors KW - Vitamin D UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39948705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Vitamin+D+Receptor+Agonists+can+Prevent+and+Treat+Experimental+Autoimmune+Uveoretinitis&rft.au=Zhu%2C+W%3BTang%2C+J%3BUskokovic%2C+M+R%3BSilver%2C+P+B%3BSu%2C+S+B%3BChan%2C+C.-C.%3BAdorini%2C+L%3BCaspi%2C+R+R&rft.aulast=Zhu&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti-Inflammatory Molecules, GC-BP and TREM2, are Constitutively Expressed in the Mouse Eye T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39947410; 4196584 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Collins, A.B.D. AU - Korman, B D AU - Yu, C. AU - Liu, X AU - Mahdi, R M AU - Bush, R A AU - Ma, X. AU - Egwuagu, C E AU - Gery, I Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Eye UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39947410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Anti-Inflammatory+Molecules%2C+GC-BP+and+TREM2%2C+are+Constitutively+Expressed+in+the+Mouse+Eye&rft.au=Collins%2C+A.B.D.%3BKorman%2C+B+D%3BYu%2C+C.%3BLiu%2C+X%3BMahdi%2C+R+M%3BBush%2C+R+A%3BMa%2C+X.%3BEgwuagu%2C+C+E%3BGery%2C+I&rft.aulast=Collins&rft.aufirst=A.B.D.&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Carotenoids and Cataract in the Age-Related Eye Disease Study T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39945762; 4199594 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Jain, N AU - SanGiovanni, J P AU - Chew, E Y AU - Agron, E AU - Reed, G F AU - Sperduto, R D AU - Clemons, T E AU - Seddon, J M AU - Ferris, F L Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Eye diseases KW - Carotenoids KW - Cataracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Dietary+Carotenoids+and+Cataract+in+the+Age-Related+Eye+Disease+Study&rft.au=Jain%2C+N%3BSanGiovanni%2C+J+P%3BChew%2C+E+Y%3BAgron%2C+E%3BReed%2C+G+F%3BSperduto%2C+R+D%3BClemons%2C+T+E%3BSeddon%2C+J+M%3BFerris%2C+F+L&rft.aulast=Jain&rft.aufirst=N&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Chemokine CCL2/MCP-1 Protects against Light Damage, but not by Cell Recruitment T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39943627; 4201065 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Bush, R A AU - Chan, C.-C. AU - Takase, H AU - Santos-Muffley, M AU - Tuo, J AU - Howard, O.M. Z. AU - Kuziel, W A AU - Gery, I Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - CCL2 protein KW - Chemokines KW - Light effects KW - Recruitment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39943627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=The+Chemokine+CCL2%2FMCP-1+Protects+against+Light+Damage%2C+but+not+by+Cell+Recruitment&rft.au=Bush%2C+R+A%3BChan%2C+C.-C.%3BTakase%2C+H%3BSantos-Muffley%2C+M%3BTuo%2C+J%3BHoward%2C+O.M.+Z.%3BKuziel%2C+W+A%3BGery%2C+I&rft.aulast=Bush&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conversion of aB-crystallin Promoter Activity from Mouse to Blind Mole Rat by Site-Specific Mutagenesis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39934293; 4197936 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Li, Y. AU - Hough, R B AU - Piatigorsky, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Mutagenesis KW - Promoters KW - A-crystallin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Conversion+of+aB-crystallin+Promoter+Activity+from+Mouse+to+Blind+Mole+Rat+by+Site-Specific+Mutagenesis&rft.au=Li%2C+Y.%3BHough%2C+R+B%3BPiatigorsky%2C+J&rft.aulast=Li&rft.aufirst=Y.&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retinoschisin Expression and Localization in Rodent Pineal and Consequences of Mouse RS1 Gene Knockout T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39934084; 4200691 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Takada, Y AU - Fariss, R N AU - Moller, M AU - Bush, R A AU - Sieving, P A Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pineal gland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Retinoschisin+Expression+and+Localization+in+Rodent+Pineal+and+Consequences+of+Mouse+RS1+Gene+Knockout&rft.au=Takada%2C+Y%3BFariss%2C+R+N%3BMoller%2C+M%3BBush%2C+R+A%3BSieving%2C+P+A&rft.aulast=Takada&rft.aufirst=Y&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNA Interference of Macrophage Migration Inhibitory Factor in B16-F10 Mouse Melanoma Cells Delays Tumor Establishment T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39933793; 4200579 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Culp Jr, W AU - McKenna, K C AU - Mooney, D AU - Meyer, E AU - Pisa, P AU - Garland, D Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Melanoma KW - RNA-mediated interference KW - Macrophage migration inhibitory factor KW - Tumors KW - Macrophages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=RNA+Interference+of+Macrophage+Migration+Inhibitory+Factor+in+B16-F10+Mouse+Melanoma+Cells+Delays+Tumor+Establishment&rft.au=Culp+Jr%2C+W%3BMcKenna%2C+K+C%3BMooney%2C+D%3BMeyer%2C+E%3BPisa%2C+P%3BGarland%2C+D&rft.aulast=Culp+Jr&rft.aufirst=W&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transporter-Like GABA Excitation of Horizontal and Bipolar Cells in Zebrafish Distal Retina T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39931678; 4197575 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Nelson, R F AU - Bender, A M AU - Connaughton, V P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Retina KW - Bipolar cells KW - Horizontal cells KW - ^g-Aminobutyric acid KW - Freshwater fish KW - Danio rerio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Transporter-Like+GABA+Excitation+of+Horizontal+and+Bipolar+Cells+in+Zebrafish+Distal+Retina&rft.au=Nelson%2C+R+F%3BBender%2C+A+M%3BConnaughton%2C+V+P&rft.aulast=Nelson&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association Between LOC387715 and Age-Related Macular Degeneration, a Replication Study with AREDS Samples T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39925491; 4200875 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Ross, R J AU - Bojanowski, C M AU - Chew, E Y AU - Ferris III, F.L. AU - Chan, C.-C. AU - Tuo, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Replication KW - Macular degeneration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Association+Between+LOC387715+and+Age-Related+Macular+Degeneration%2C+a+Replication+Study+with+AREDS+Samples&rft.au=Ross%2C+R+J%3BBojanowski%2C+C+M%3BChew%2C+E+Y%3BFerris+III%2C+F.L.%3BChan%2C+C.-C.%3BTuo%2C+J&rft.aulast=Ross&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemokine and Chemokine Receptor Expression in Two Models of Primary Intraocular Lymphoma T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39924493; 4202185 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Gonzales, J A AU - Shen, D AU - Zhou, M AU - Li, Z. AU - Hochman, J AU - Nussenblatt, R AU - Tuo, J AU - Chan, C.-C. Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Lymphoma KW - Chemokine receptors KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Chemokine+and+Chemokine+Receptor+Expression+in+Two+Models+of+Primary+Intraocular+Lymphoma&rft.au=Gonzales%2C+J+A%3BShen%2C+D%3BZhou%2C+M%3BLi%2C+Z.%3BHochman%2C+J%3BNussenblatt%2C+R%3BTuo%2C+J%3BChan%2C+C.-C.&rft.aulast=Gonzales&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of TLR-3 Signaling in Human Retinal Endothelial and Human Retinal Pigment Epithelial Cells T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39916082; 4200560 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Hooper, L C AU - Nagineni, C N AU - Detrick, B AU - Hooks, J J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Signal transduction KW - Retinal pigment epithelium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39916082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Comparison+of+TLR-3+Signaling+in+Human+Retinal+Endothelial+and+Human+Retinal+Pigment+Epithelial+Cells&rft.au=Hooper%2C+L+C%3BNagineni%2C+C+N%3BDetrick%2C+B%3BHooks%2C+J+J&rft.aulast=Hooper&rft.aufirst=L&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Abundant Gelsolin-Like Corneal Protein of Zebrafish is Adseverin T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39908183; 4199463 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Jia, S AU - Spencer, M AU - Omelchenko, M AU - Koonin, E AU - Piatigorsky, J Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Cornea KW - Freshwater fish KW - Danio rerio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39908183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=The+Abundant+Gelsolin-Like+Corneal+Protein+of+Zebrafish+is+Adseverin&rft.au=Jia%2C+S%3BSpencer%2C+M%3BOmelchenko%2C+M%3BKoonin%2C+E%3BPiatigorsky%2C+J&rft.aulast=Jia&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pigment Epithelium-Derived Factor (PEDF) and ATP Synthase: A Mechanism of Action for Inhibition of Angiogenesis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39902950; 4196634 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Becerra, S AU - Notari, L AU - Mueller, D AU - Higuti, T AU - Arakaki,N. Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Pigments KW - Pigment epithelium-derived factor KW - ATP synthase KW - Angiogenesis KW - ATP UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Pigment+Epithelium-Derived+Factor+%28PEDF%29+and+ATP+Synthase%3A+A+Mechanism+of+Action+for+Inhibition+of+Angiogenesis&rft.au=Becerra%2C+S%3BNotari%2C+L%3BMueller%2C+D%3BHiguti%2C+T%3BArakaki%2CN.&rft.aulast=Becerra&rft.aufirst=S&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blue Light Induces A2E Oxidation in Rat Eyes T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39902551; 4196561 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Wielgus, A R AU - Lih, F B AU - Tomer, K B AU - Chignell, C F AU - Roberts, J E Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Oxidation KW - Light effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Blue+Light+Induces+A2E+Oxidation+in+Rat+Eyes&rft.au=Wielgus%2C+A+R%3BLih%2C+F+B%3BTomer%2C+K+B%3BChignell%2C+C+F%3BRoberts%2C+J+E&rft.aulast=Wielgus&rft.aufirst=A&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum Leptin Levels in Autoimmune Uveitis T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39897559; 4199924 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Sen, H AU - Li, Z. AU - Reed, G AU - Lim, W.-K. AU - Kurup, S AU - Levy-Clarke, G AU - Nussenblatt, R B Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Uveitis KW - Leptin KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Serum+Leptin+Levels+in+Autoimmune+Uveitis&rft.au=Sen%2C+H%3BLi%2C+Z.%3BReed%2C+G%3BLim%2C+W.-K.%3BKurup%2C+S%3BLevy-Clarke%2C+G%3BNussenblatt%2C+R+B&rft.aulast=Sen&rft.aufirst=H&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evolutionary Dynamics of Prokaryotic Transcriptional Regulatory Networks AN - 19437772; 6855927 AB - The structure of complex transcriptional regulatory networks has been studied extensively in certain model organisms. However, the evolutionary dynamics of these networks across organisms, which would reveal important principles of adaptive regulatory changes, are poorly understood. We use the known transcriptional regulatory network of Escherichia coli to analyse the conservation patterns of this network across 175 prokaryotic genomes, and predict components of the regulatory networks for these organisms. We observe that transcription factors are typically less conserved than their target genes and evolve independently of them, with different organisms evolving distinct repertoires of transcription factors responding to specific signals. We show that prokaryotic transcriptional regulatory networks have evolved principally through widespread tinkering of transcriptional interactions at the local level by embedding orthologous genes in different types of regulatory motifs. Different transcription factors have emerged independently as dominant regulatory hubs in various organisms, suggesting that they have convergently acquired similar network structures approximating a scale-free topology. We note that organisms with similar lifestyles across a wide phylogenetic range tend to conserve equivalent interactions and network motifs. Thus, organism-specific optimal network designs appear to have evolved due to selection for specific transcription factors and transcriptional interactions, allowing responses to prevalent environmental stimuli. The methods for biological network analysis introduced here can be applied generally to study other networks, and these predictions can be used to guide specific experiments. JF - Journal of Molecular Biology AU - Madan Babu, M AU - Teichmann, SA AU - Aravind, L AD - National Institutes of Health, MD 20894, USA, madanm@mrc-lmb.cam.ac.uk Y1 - 2006/04/28/ PY - 2006 DA - 2006 Apr 28 SP - 614 EP - 633 VL - 358 IS - 2 SN - 0022-2836, 0022-2836 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Phylogeny KW - Transcription factors KW - Escherichia coli KW - Environmental effects KW - Evolution KW - Models KW - N 14825:Gene Regulation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19437772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Evolutionary+Dynamics+of+Prokaryotic+Transcriptional+Regulatory+Networks&rft.au=Madan+Babu%2C+M%3BTeichmann%2C+SA%3BAravind%2C+L&rft.aulast=Madan+Babu&rft.aufirst=M&rft.date=2006-04-28&rft.volume=358&rft.issue=2&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.02.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Transcription factors; Environmental effects; Evolution; Models; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2006.02.019 ER - TY - JOUR T1 - Three-stage Regulation of the Amphibolic gal Operon: From Repressosome to GalR-free DNA AN - 17178400; 6855904 AB - The gal operon of Escherichia coli is negatively regulated by the Gal repressosome, a higher order nucleoprotein complex containing a DNA loop that encompasses two gal promoters. In the repressosome structure, Gal repressor (GalR) dimers are bound to the two operator sites, flanking the promoter region, thus generating a DNA loop. The DNA loop is stabilized by binding of the architectural HU protein to the apex of the loop, and negative supercoiling. The gal promoters are also regulated in opposite directions by GalR without DNA looping. The repressosome-mediated as well as looping-independent transcription regulation of the two promoters is lifted in the presence of the inducer d-galactose. We tested the effect of d-galactose on various DNA-protein and protein-protein interactions of different regulatory complexes and on transcription repression in vitro. We found that the inducer breaks up the repressosome with clear intermediates in a concentration-dependent manner. The sequential disassembly generates different stages of regulation of the gal operon. The d-galactose-dependent switch from one stage of regulation to another satisfies the amphibolic requirement of the gal operon. on. JF - Journal of Molecular Biology AU - Semsey, S AU - Virnik, K AU - Adhya, S AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA, sadhya@helix.nih.gov Y1 - 2006/04/28/ PY - 2006 DA - 2006 Apr 28 SP - 355 EP - 363 VL - 358 IS - 2 SN - 0022-2836, 0022-2836 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Nucleoproteins KW - D-Galactose KW - Transcription KW - double prime HU protein KW - GalR protein KW - Operators KW - Promoters KW - Supercoiling KW - Gene regulation KW - Escherichia coli KW - DNA KW - Repressors KW - Protein interaction KW - Galactose operon KW - J 02725:DNA KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17178400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Three-stage+Regulation+of+the+Amphibolic+gal+Operon%3A+From+Repressosome+to+GalR-free+DNA&rft.au=Semsey%2C+S%3BVirnik%2C+K%3BAdhya%2C+S&rft.aulast=Semsey&rft.aufirst=S&rft.date=2006-04-28&rft.volume=358&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Nucleoproteins; D-Galactose; Transcription; double prime HU protein; Operators; GalR protein; Promoters; Supercoiling; Gene regulation; DNA; Repressors; Galactose operon; Protein interaction; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2006.02.022 ER - TY - CPAPER T1 - M-CSF and GM-CSFDependent Macrophage Subpopulations Demonstrate Divergent Characteristics that could Contribute to Atherosclerotic Plaque Formation T2 - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AN - 40081488; 4236838 JF - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AU - Waldo, Stephen W AU - Li, Yifu AU - Buono, Chiara AU - Billings, Eric M AU - Kruth, Howard S Y1 - 2006/04/27/ PY - 2006 DA - 2006 Apr 27 KW - Granulocyte-macrophage colony-stimulating factor KW - Arteriosclerosis KW - Macrophage colony-stimulating factor KW - Macrophages KW - Subpopulations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40081488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.atitle=M-CSF+and+GM-CSFDependent+Macrophage+Subpopulations+Demonstrate+Divergent+Characteristics+that+could+Contribute+to+Atherosclerotic+Plaque+Formation&rft.au=Waldo%2C+Stephen+W%3BLi%2C+Yifu%3BBuono%2C+Chiara%3BBillings%2C+Eric+M%3BKruth%2C+Howard+S&rft.aulast=Waldo&rft.aufirst=Stephen&rft.date=2006-04-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1144786749589Final%20P rogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Canonical Transient Receptor Potential Channels in Receptor-Dependent Regulation of Vascular Cell Adhesion Molecule-1 in Human Coronary Artery Endothelium T2 - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AN - 40037915; 4236864 JF - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AU - Vazquez, Guillermo AU - Putney Jr, James W Y1 - 2006/04/27/ PY - 2006 DA - 2006 Apr 27 KW - Channels KW - Transient receptor potential proteins KW - Endothelium KW - Vascular cell adhesion molecule 1 KW - Coronary artery KW - Epithelia KW - Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.atitle=Role+of+Canonical+Transient+Receptor+Potential+Channels+in+Receptor-Dependent+Regulation+of+Vascular+Cell+Adhesion+Molecule-1+in+Human+Coronary+Artery+Endothelium&rft.au=Vazquez%2C+Guillermo%3BPutney+Jr%2C+James+W&rft.aulast=Vazquez&rft.aufirst=Guillermo&rft.date=2006-04-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1144786749589Final%20P rogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LXRs Inhibit Cholesterol Accumulation and LDL Uptake by Micropinocytosis in Macrophages Differentiated from Human Monocytes with M-CSF In Vitro T2 - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AN - 39979506; 4236616 JF - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AU - Buono, Chiara Y1 - 2006/04/27/ PY - 2006 DA - 2006 Apr 27 KW - Macrophage colony-stimulating factor KW - Monocytes KW - Cholesterol KW - Macrophages KW - Lipoproteins (low density) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39979506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.atitle=LXRs+Inhibit+Cholesterol+Accumulation+and+LDL+Uptake+by+Micropinocytosis+in+Macrophages+Differentiated+from+Human+Monocytes+with+M-CSF+In+Vitro&rft.au=Buono%2C+Chiara&rft.aulast=Buono&rft.aufirst=Chiara&rft.date=2006-04-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1144786749589Final%20P rogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Method to Study the Network Formation of Endothelial Cells in Response to Angiogenic Factors T2 - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AN - 39941723; 4236778 JF - 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology AU - Amyot, Franck AU - Siavosh, Asmaneh AU - Gandjbakhche, Amir Y1 - 2006/04/27/ PY - 2006 DA - 2006 Apr 27 KW - Endothelial cells KW - Angiogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39941723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.atitle=Quantitative+Method+to+Study+the+Network+Formation+of+Endothelial+Cells+in+Response+to+Angiogenic+Factors&rft.au=Amyot%2C+Franck%3BSiavosh%2C+Asmaneh%3BGandjbakhche%2C+Amir&rft.aulast=Amyot&rft.aufirst=Franck&rft.date=2006-04-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Conference+on+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1144786749589Final%20P rogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Two Putative Taste Signal Transduction Components T2 - 28th Annual Meeting of the Association for Chemoreception Sciences AN - 40142052; 4289580 JF - 28th Annual Meeting of the Association for Chemoreception Sciences AU - Lopezjimenez, N D AU - Cavenagh, M M AU - Sainz, E AU - Battey, J F AU - Sullivan, S L Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 KW - Signal transduction KW - Taste KW - Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40142052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.atitle=Identification+of+Two+Putative+Taste+Signal+Transduction+Components&rft.au=Lopezjimenez%2C+N+D%3BCavenagh%2C+M+M%3BSainz%2C+E%3BBattey%2C+J+F%3BSullivan%2C+S+L&rft.aulast=Lopezjimenez&rft.aufirst=N&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/clientuploads/FinalCompleteShortProgram.pdf?PHPS ESSID=e246cad1094baecd32bba67e129546a6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and Activity-Dependent Refinement of the Olfactory Intrabulbar Map T2 - 28th Annual Meeting of the Association for Chemoreception Sciences AN - 40122289; 4289511 JF - 28th Annual Meeting of the Association for Chemoreception Sciences AU - Belluscio, L Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 KW - Olfaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40122289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.atitle=Development+and+Activity-Dependent+Refinement+of+the+Olfactory+Intrabulbar+Map&rft.au=Belluscio%2C+L&rft.aulast=Belluscio&rft.aufirst=L&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/clientuploads/FinalCompleteShortProgram.pdf?PHPS ESSID=e246cad1094baecd32bba67e129546a6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Properties of the Seven Transmembrane Core Domains of the Human T1RS T2 - 28th Annual Meeting of the Association for Chemoreception Sciences AN - 40090732; 4289874 JF - 28th Annual Meeting of the Association for Chemoreception Sciences AU - Sainz, E AU - Cavenagh, M M AU - Lopezjimenez, N D AU - Battey, J F AU - Northup, J K AU - Sullivan, S L Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 KW - Cores UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40090732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.atitle=Properties+of+the+Seven+Transmembrane+Core+Domains+of+the+Human+T1RS&rft.au=Sainz%2C+E%3BCavenagh%2C+M+M%3BLopezjimenez%2C+N+D%3BBattey%2C+J+F%3BNorthup%2C+J+K%3BSullivan%2C+S+L&rft.aulast=Sainz&rft.aufirst=E&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/clientuploads/FinalCompleteShortProgram.pdf?PHPS ESSID=e246cad1094baecd32bba67e129546a6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis and Hcv: An Un-Solved Phenomena T2 - 41st Annual Meeting of the European Association for the Study of the Liver AN - 39932490; 4167228 JF - 41st Annual Meeting of the European Association for the Study of the Liver AU - Zekri, A N AU - Bahnassy, A A AU - El-Shahaby, A M AU - El-Guendy, N AU - Hafez, M Mohamed AU - Radwn, S AU - El-Leathey, H AU - Abdel-Wahab, S A AU - Khaled, H M Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 KW - Apoptosis KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=41st+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Apoptosis+and+Hcv%3A+An+Un-Solved+Phenomena&rft.au=Zekri%2C+A+N%3BBahnassy%2C+A+A%3BEl-Shahaby%2C+A+M%3BEl-Guendy%2C+N%3BHafez%2C+M+Mohamed%3BRadwn%2C+S%3BEl-Leathey%2C+H%3BAbdel-Wahab%2C+S+A%3BKhaled%2C+H+M&rft.aulast=Zekri&rft.aufirst=A&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=41st+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.easl.ch/easl2006/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Benefits from Soybeans T2 - 4th Asian Congress of Dietetics (ACD 2006) AN - 40145128; 4287271 JF - 4th Asian Congress of Dietetics (ACD 2006) AU - Milner, John Y1 - 2006/04/23/ PY - 2006 DA - 2006 Apr 23 KW - Soybeans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40145128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Asian+Congress+of+Dietetics+%28ACD+2006%29&rft.atitle=Health+Benefits+from+Soybeans&rft.au=Milner%2C+John&rft.aulast=Milner&rft.aufirst=John&rft.date=2006-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Asian+Congress+of+Dietetics+%28ACD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asiancongressofdietetics.com/finalprogramme.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Engineering of Cell Lines using Bio-Informatics Tools: Focus on Adhesion in Hela Cells T2 - 10th Annual Conference on Cell Culture Engineering AN - 40028805; 4215812 JF - 10th Annual Conference on Cell Culture Engineering AU - Jaluria, Pratik Y1 - 2006/04/23/ PY - 2006 DA - 2006 Apr 23 KW - Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40028805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Conference+on+Cell+Culture+Engineering&rft.atitle=The+Engineering+of+Cell+Lines+using+Bio-Informatics+Tools%3A+Focus+on+Adhesion+in+Hela+Cells&rft.au=Jaluria%2C+Pratik&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2006-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Conference+on+Cell+Culture+Engineering&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/6acfin.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring Growth Properties of Mammalian Cells with Bio-Informatics Tools T2 - 10th Annual Conference on Cell Culture Engineering AN - 39979642; 4215818 JF - 10th Annual Conference on Cell Culture Engineering AU - Shiloach, Joseph Y1 - 2006/04/23/ PY - 2006 DA - 2006 Apr 23 KW - Mammalian cells KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39979642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Conference+on+Cell+Culture+Engineering&rft.atitle=Exploring+Growth+Properties+of+Mammalian+Cells+with+Bio-Informatics+Tools&rft.au=Shiloach%2C+Joseph&rft.aulast=Shiloach&rft.aufirst=Joseph&rft.date=2006-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Conference+on+Cell+Culture+Engineering&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/6acfin.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-Range Genetic Interactions in the Human Genome T2 - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AN - 40025540; 4188261 JF - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AU - Farrell, Catherine M Y1 - 2006/04/21/ PY - 2006 DA - 2006 Apr 21 KW - Genomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40025540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.atitle=Long-Range+Genetic+Interactions+in+the+Human+Genome&rft.au=Farrell%2C+Catherine+M&rft.aulast=Farrell&rft.aufirst=Catherine&rft.date=2006-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=78 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LCRs, Extragenic Transcription and Histone Modifications T2 - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AN - 40000613; 4188256 JF - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AU - Dean, Ann Y1 - 2006/04/21/ PY - 2006 DA - 2006 Apr 21 KW - Histones KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.atitle=LCRs%2C+Extragenic+Transcription+and+Histone+Modifications&rft.au=Dean%2C+Ann&rft.aulast=Dean&rft.aufirst=Ann&rft.date=2006-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=78 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcription Factor Mobility and Promoter Progression T2 - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AN - 39989031; 4188281 JF - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AU - Hager, Gordon L Y1 - 2006/04/21/ PY - 2006 DA - 2006 Apr 21 KW - Promoters KW - Mobility KW - Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39989031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.atitle=Transcription+Factor+Mobility+and+Promoter+Progression&rft.au=Hager%2C+Gordon+L&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2006-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=78 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulating Transcription by ATP-Dependent Chromatin Remodeling Complexes T2 - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AN - 39948611; 4188287 JF - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AU - Wu, Carl Y1 - 2006/04/21/ PY - 2006 DA - 2006 Apr 21 KW - Chromatin remodeling KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39948611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.atitle=Regulating+Transcription+by+ATP-Dependent+Chromatin+Remodeling+Complexes&rft.au=Wu%2C+Carl&rft.aulast=Wu&rft.aufirst=Carl&rft.date=2006-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=78 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Chromatin Binding Protein Brd4 Interacts with P-TEFb and Stimulates RNA Polymerase II Dependent Transcription In Vivo T2 - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AN - 39942411; 4188265 JF - 2006 Keystone Symposia on Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3) AU - Ozato, Keiko Y1 - 2006/04/21/ PY - 2006 DA - 2006 Apr 21 KW - DNA-directed RNA polymerase KW - Transcription KW - Chromatin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.atitle=The+Chromatin+Binding+Protein+Brd4+Interacts+with+P-TEFb+and+Stimulates+RNA+Polymerase+II+Dependent+Transcription+In+Vivo&rft.au=Ozato%2C+Keiko&rft.aulast=Ozato&rft.aufirst=Keiko&rft.date=2006-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Regulation+of+Eukaryotic+Transcription%3A+From+Chromatin+to+mRNA+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=78 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. AN - 67880639; 16625008 AB - Persistent acute respiratory distress syndrome (ARDS) is characterized by excessive fibroproliferation, ongoing inflammation, prolonged mechanical ventilation, and a substantial risk of death. Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS. We randomly assigned 180 patients with ARDS of at least seven days' duration to receive either methylprednisolone or placebo in a double-blind fashion. The primary end point was mortality at 60 days. Secondary end points included the number of ventilator-free days and organ-failure-free days, biochemical markers of inflammation and fibroproliferation, and infectious complications. At 60 days, the hospital mortality rate was 28.6 percent in the placebo group (95 percent confidence interval, 20.3 to 38.6 percent) and 29.2 percent in the methylprednisolone group (95 percent confidence interval, 20.8 to 39.4 percent; P=1.0); at 180 days, the rates were 31.9 percent (95 percent confidence interval, 23.2 to 42.0 percent) and 31.5 percent (95 percent confidence interval, 22.8 to 41.7 percent; P=1.0), respectively. Methylprednisolone was associated with significantly increased 60- and 180-day mortality rates among patients enrolled at least 14 days after the onset of ARDS. Methylprednisolone increased the number of ventilator-free and shock-free days during the first 28 days in association with an improvement in oxygenation, respiratory-system compliance, and blood pressure with fewer days of vasopressor therapy. As compared with placebo, methylprednisolone did not increase the rate of infectious complications but was associated with a higher rate of neuromuscular weakness. These results do not support the routine use of methylprednisolone for persistent ARDS despite the improvement in cardiopulmonary physiology. In addition, starting methylprednisolone therapy more than two weeks after the onset of ARDS may increase the risk of death. (ClinicalTrials.gov number, NCT00295269.). Copyright 2006 Massachusetts Medical Society. JF - The New England journal of medicine AU - Steinberg, Kenneth P AU - Hudson, Leonard D AU - Goodman, Richard B AU - Hough, Catherine Lee AU - Lanken, Paul N AU - Hyzy, Robert AU - Thompson, B Taylor AU - Ancukiewicz, Marek AU - National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network AD - Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave., Seattle, WA 98104, USA. steinkp@u.washington.edu ; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network Y1 - 2006/04/20/ PY - 2006 DA - 2006 Apr 20 SP - 1671 EP - 1684 VL - 354 IS - 16 KW - Blood Glucose KW - 0 KW - Glucocorticoids KW - Oxygen KW - S88TT14065 KW - Methylprednisolone KW - X4W7ZR7023 KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Injections, Intravenous KW - Combined Modality Therapy KW - Humans KW - Shock, Septic -- etiology KW - Respiration, Artificial KW - Inflammation -- drug therapy KW - Blood Glucose -- analysis KW - Pneumonia -- etiology KW - Critical Illness KW - Oxygen -- blood KW - Muscle Weakness -- chemically induced KW - Hospital Mortality KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Blood Pressure -- drug effects KW - Female KW - Male KW - Survival Analysis KW - Respiratory Distress Syndrome, Adult -- mortality KW - Methylprednisolone -- therapeutic use KW - Methylprednisolone -- pharmacology KW - Respiratory Distress Syndrome, Adult -- drug therapy KW - Respiratory Distress Syndrome, Adult -- physiopathology KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Methylprednisolone -- adverse effects KW - Glucocorticoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67880639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Efficacy+and+safety+of+corticosteroids+for+persistent+acute+respiratory+distress+syndrome.&rft.au=Steinberg%2C+Kenneth+P%3BHudson%2C+Leonard+D%3BGoodman%2C+Richard+B%3BHough%2C+Catherine+Lee%3BLanken%2C+Paul+N%3BHyzy%2C+Robert%3BThompson%2C+B+Taylor%3BAncukiewicz%2C+Marek%3BNational+Heart%2C+Lung%2C+and+Blood+Institute+Acute+Respiratory+Distress+Syndrome+%28ARDS%29+Clinical+Trials+Network&rft.aulast=Steinberg&rft.aufirst=Kenneth&rft.date=2006-04-20&rft.volume=354&rft.issue=16&rft.spage=1671&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-04-20 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00295269; ClinicalTrials.gov N1 - SuppNotes - Comment In: N Engl J Med. 2006 Jul 20;355(3):317-8; author reply 318-9 [16856285] Crit Care. 2007;11(4):310 [17666114] Can J Anaesth. 2007 Sep;54(9):765-6 [17766744] N Engl J Med. 2006 Jul 20;355(3):316-7; author reply 318-9 [16855276] N Engl J Med. 2006 Jul 20;355(3):317; author reply 318-9 [16858835] N Engl J Med. 2006 Jul 20;355(3):317; author reply 318-9 [16858836] N Engl J Med. 2006 Sep 14;355(11):1175; author reply 1176 [16977702] N Engl J Med. 2006 Apr 20;354(16):1739-42 [16625013] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a quantitative cell-based ELISA, for a humanized anti-IL-2/IL-15 receptor beta antibody (HuMik beta sub(1)), and correlation with functional activity using an antigen-transfected murine cell line AN - 19839867; 6855730 AB - The HuMik beta sub(1), a humanized IgG1 monoclonal antibody directed toward the IL-2/IL-15 receptor beta -chain (CD122), inhibits the actions of the inflammatory cytokine IL-15, and may be useful for immunotherapy of an array of autoimmune disorders as well as diseases associated with the retrovirus human T-cell lymphotrophic virus 1 (HTLV-1). In order to facilitate the production of material for clinical investigation, we developed a cell-based ELISA (CbELISA) for measuring the binding activity, as a potential biological activity marker, of the HuMik beta sub(1) monoclonal antibody to a transfected 32D mouse cell line (32D beta ) expressing IL-2R beta antigen on the cell surface. There is specific binding of HuMik beta sub(1) to the transfected cell line, titrating out in the concentration range of 1-1000ng/ml. Under identical conditions, there was no binding of HuMik beta sub(1) to the parent cell line 32D. Satisfactory binding curves with HuMik beta sub(1) were obtained with 32D beta cells grown between 3 and 19 passages in culture and at seed densities of 2x10 super(5)-4x10 super(6) cells/well. The binding was specific for Mik beta antibodies recognizing the IL-2/IL-15 receptor beta subunit as demonstrated by binding of HuMik beta sub(1), Mik beta sub(2) and Mik beta sub(3) antibodies, and lack of binding of irrelevant humanized and chimeric antibodies and isotype-matched human IgG1 to the 32D beta cell. Also, the human IgG1 and irrelevant humanized and chimeric antibodies did not interfere with the HuMik beta sub(1) binding. The assay could detect changes in binding activity of HuMik beta sub(1) antibody under stressful conditions (heat and low pH) and the results paralleled the effect of stress on the physicochemical characteristics. More importantly, the binding activity shows an apparent correlation to inhibition of IL-15-induced proliferation of 32D beta cells with HuMik beta sub(1). In conclusion, the cell-based ELISA method represents a simple, reproducible accurate quantitative assay for monitoring HuMik beta sub(1) activity and could be used as a potency marker assay for monitoring the lot-lot consistency and functional stability of HuMik beta sub(1) product. JF - Journal of Immunological Methods AU - Yang, X Y AU - Chen, E AU - Jiang, H AU - Hartmann, W K AU - Mitra, G AU - Hecht, T AU - Soman, G AD - Biopharmaceutical Development Program, SAIC Frederick Inc., NCI-Frederick, FortDetrick, Frederick, MD 21702, United States, somang@mail.ncifcrf.gov Y1 - 2006/04/20/ PY - 2006 DA - 2006 Apr 20 SP - 71 EP - 80 PB - Elsevier B.V. VL - 311 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Cell surface KW - Interleukin 15 receptors KW - Enzyme-linked immunosorbent assay KW - Interleukin 2 KW - Monoclonal antibodies KW - Immunotherapy KW - Human T-lymphotropic virus 1 KW - Autoimmune diseases KW - Stress KW - Cell culture KW - biomarkers KW - Interleukin 2 receptors KW - Inflammation KW - Retrovirus KW - Interleukin 15 KW - Heat KW - CD122 antigen KW - Lymphocytes T KW - Immunoglobulin G KW - Cell proliferation KW - pH effects KW - V 22350:Immunology KW - W3 33240:Immunology KW - F 06704:Immunoassays KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Development+of+a+quantitative+cell-based+ELISA%2C+for+a+humanized+anti-IL-2%2FIL-15+receptor+beta+antibody+%28HuMik+beta+sub%281%29%29%2C+and+correlation+with+functional+activity+using+an+antigen-transfected+murine+cell+line&rft.au=Yang%2C+X+Y%3BChen%2C+E%3BJiang%2C+H%3BHartmann%2C+W+K%3BMitra%2C+G%3BHecht%2C+T%3BSoman%2C+G&rft.aulast=Yang&rft.aufirst=X&rft.date=2006-04-20&rft.volume=311&rft.issue=1-2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Enzyme-linked immunosorbent assay; Interleukin 15 receptors; Interleukin 2; Monoclonal antibodies; Immunotherapy; Autoimmune diseases; Stress; Cell culture; biomarkers; Interleukin 2 receptors; Inflammation; Retrovirus; Interleukin 15; CD122 antigen; Heat; Immunoglobulin G; Lymphocytes T; Cell proliferation; pH effects; Human T-lymphotropic virus 1 DO - http://dx.doi.org/10.1016/j.jim.2006.01.014 ER - TY - CPAPER T1 - Overview of NIAID/NIH TB Programs: The Direction for TB Vaccines T2 - Second International Conference on TB Vaccines for the World (TBV 2006) AN - 39945087; 4165679 JF - Second International Conference on TB Vaccines for the World (TBV 2006) AU - Sizemore, Christine Y1 - 2006/04/19/ PY - 2006 DA - 2006 Apr 19 KW - Vaccines KW - Reviews KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.atitle=Overview+of+NIAID%2FNIH+TB+Programs%3A+The+Direction+for+TB+Vaccines&rft.au=Sizemore%2C+Christine&rft.aulast=Sizemore&rft.aufirst=Christine&rft.date=2006-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2006/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sleeping beauty: a novel cancer gene discovery tool. AN - 67927066; 16651372 AB - The National Cancer Institute and the National Human Genome Research Institute recently announced a 3-year 100-million-dollar pilot study to use large-scale resequencing of genes in human tumors to identify new cancer genes. The hope is that some of these genes can be used as drug targets for developing better therapeutics for treating cancer. Although this effort will identify new cancer genes, it could be made more efficient by preferentially resequencing genes identified as novel candidate cancer genes in animal models of cancer. Although retroviral insertional mutagenesis has proven to be an effective tool for identifying novel cancer genes in the mouse, these studies are limited by the fact that retroviral mutagenesis primarily induces hematopoietic and mammary cancer, but little else, while the majority of cancers affecting humans are solid tumors. Recently, two groups have shown that sleeping beauty (SB) transposon-based insertional mutagenesis can also identify novel candidate cancer genes in the mouse. Unlike retroviral infection, SB transposition can be controlled to mutagenize any target tissue and thus potentially induce many different kinds of cancer, including solid tumors. SB transposition in animal models of cancer could therefore greatly facilitate the identification of novel human cancer genes and the development of better cancer therapies. JF - Human molecular genetics AU - Dupuy, Adam J AU - Jenkins, Nancy A AU - Copeland, Neal G AD - Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2006/04/15/ PY - 2006 DA - 2006 Apr 15 SP - R75 EP - R79 VL - 15 Spec No 1 SN - 0964-6906, 0964-6906 KW - DNA Transposable Elements KW - 0 KW - Transposases KW - EC 2.7.7.- KW - sleeping beauty transposase, human KW - Index Medicus KW - Animals KW - Models, Genetic KW - Humans KW - Disease Models, Animal KW - Mice KW - Genes, Neoplasm KW - Transposases -- genetics KW - DNA Transposable Elements -- genetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67927066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Sleeping+beauty%3A+a+novel+cancer+gene+discovery+tool.&rft.au=Dupuy%2C+Adam+J%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G&rft.aulast=Dupuy&rft.aufirst=Adam&rft.date=2006-04-15&rft.volume=15+Spec+No+1&rft.issue=&rft.spage=R75&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-27 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). AN - 67852434; 16488885 AB - Many cognate low molecular weight (LMW) agonists bind to seven transmembrane-spanning receptors within their transmembrane helices (TMHs). The thienopyrimidine org41841 was identified previously as an agonist for the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and suggested to bind within its TMHs because it did not compete for LH binding to the LHCGR ectodomain. Because of its high homology with LHCGR, we predicted that thyroid-stimulating hormone receptor (TSHR) might be activated by org41841 also. We show that org41841 is a partial agonist for TSHR but with lower potency than for LHCGR. Analysis of three-dimensional molecular models of TSHR and LHCGR predicted a binding pocket for org41841 in common clefts between TMHs 3, 4, 5, 6, and 7 and extracellular loop 2 in both receptors. Evidence for this binding pocket was obtained in signaling studies with chimeric receptors that exhibited improved responses to org41841. Furthermore, a key receptor-ligand interaction between the highly conserved negatively charged E3.37 and the amino group of org41841 predicted by docking of the ligand into the three-dimensional TSHR model was experimentally confirmed. These findings provide the first evidence that, in contrast to the ectodomain binding of cognate ligands, a LMW agonist can bind to and activate glycoprotein hormone receptors via interaction with their transmembrane domain. JF - The Journal of biological chemistry AU - Jäschke, Holger AU - Neumann, Susanne AU - Moore, Susanna AU - Thomas, Craig J AU - Colson, Anny-Odile AU - Costanzi, Stefano AU - Kleinau, Gunnar AU - Jiang, Jian-Kang AU - Paschke, Ralf AU - Raaka, Bruce M AU - Krause, Gerd AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA. Y1 - 2006/04/14/ PY - 2006 DA - 2006 Apr 14 SP - 9841 EP - 9844 VL - 281 IS - 15 SN - 0021-9258, 0021-9258 KW - Ligands KW - 0 KW - Org 41841 KW - Pyrimidines KW - Receptors, LH KW - Receptors, Thyrotropin KW - Recombinant Fusion Proteins KW - Thiophenes KW - thienopyrimidine KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Protein Binding KW - Recombinant Fusion Proteins -- chemistry KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Transfection KW - Genetic Vectors KW - Cyclic AMP -- metabolism KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Hydrogen Bonding KW - Mutation KW - Signal Transduction KW - Cell Line KW - Protein Conformation KW - Pyrimidines -- chemistry KW - Receptors, Thyrotropin -- chemistry KW - Thiophenes -- chemistry KW - Receptors, LH -- chemistry KW - Thiophenes -- pharmacology KW - Pyrimidines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67852434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+low+molecular+weight+agonist+signals+by+binding+to+the+transmembrane+domain+of+thyroid-stimulating+hormone+receptor+%28TSHR%29+and+luteinizing+hormone%2Fchorionic+gonadotropin+receptor+%28LHCGR%29.&rft.au=J%C3%A4schke%2C+Holger%3BNeumann%2C+Susanne%3BMoore%2C+Susanna%3BThomas%2C+Craig+J%3BColson%2C+Anny-Odile%3BCostanzi%2C+Stefano%3BKleinau%2C+Gunnar%3BJiang%2C+Jian-Kang%3BPaschke%2C+Ralf%3BRaaka%2C+Bruce+M%3BKrause%2C+Gerd%3BGershengorn%2C+Marvin+C&rft.aulast=J%C3%A4schke&rft.aufirst=Holger&rft.date=2006-04-14&rft.volume=281&rft.issue=15&rft.spage=9841&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-05 N1 - Date created - 2006-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. AN - 67858112; 16445949 AB - Telomerase, a reverse transcriptase that maintains telomere length, is highly activated in tumor cells and practically absent in somatic cells and hence considered a potential marker for tumorigenesis. A connection between telomerase activity and resistance to apoptosis has been established. Telomerase, therefore, has been proposed to represent a novel and potentially selective target for cancer therapy. Several synthetic compounds have been developed in recent years with a view to inhibit telomerase activity with telomere shortening below a critical length resulting in apoptosis. Such compounds are always highly toxic. Many plant-derived products act through the induction of apoptosis as a mechanism to suppress carcinogenesis. Curcumin, a phenolic compound isolated from the rhizome of the plant Curcuma longa Linn., has been reported to possess anti-tumor, apoptotic and anti-angiogenic properties. Apoptosis has emerged as the major mechanism by which anti-tumor agents eliminate pre-neoplastic cells or cells progressed to malignancy. The present study was undertaken to examine the mechanism of curcumin-induced apoptosis in human leukemia cell line K-562 with particular emphasis on the role of curcumin on telomerase activity. Induction of apoptosis by curcumin is initiated by the release of cytochrome c from mitochondria into the cytosol, and evidenced by the increase in DNA content in the sub-G1 region as obtained from FACS analysis. Apoptosis is mediated by the activation of caspases 3 and 8, up-regulation of the apoptotic gene bax with concomitant down-regulation of the anti-apoptotic gene bcl-2. Using TRAP assay it has been observed that curcumin inhibits telomerase activity in a dose and time-dependent manner, the inhibition being due to suppression of translocation of telomerase reverse transcriptase (TERT), a catalytic subunit, from cytosol to nucleus. Most significantly, the inhibition of telomerase activity by curcumin correlates with several parameters of apoptosis. The results suggest that telomerase status plays an important role in the induction of apoptosis in K-562 cells by curcumin. JF - Mutation research AU - Chakraborty, Sutapa AU - Ghosh, Utpal AU - Bhattacharyya, N P AU - Bhattacharya, R K AU - Roy, Madhumita AD - Environmental Carcinogenesis and Toxicology Department, Chittaranjan National Cancer Institute, 37, SP Mukherjee Road, Kolkata 700026, India. Y1 - 2006/04/11/ PY - 2006 DA - 2006 Apr 11 SP - 81 EP - 90 VL - 596 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA-Binding Proteins KW - 0 KW - Cytochromes c KW - 9007-43-6 KW - TERT protein, human KW - EC 2.7.7.49 KW - Telomerase KW - Caspases KW - EC 3.4.22.- KW - Curcumin KW - IT942ZTH98 KW - Index Medicus KW - Kinetics KW - Humans KW - DNA-Binding Proteins -- drug effects KW - Flow Cytometry KW - Caspases -- drug effects KW - K562 Cells KW - Cytochromes c -- analysis KW - Caspases -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Telomerase -- antagonists & inhibitors KW - Telomerase -- drug effects KW - Apoptosis -- drug effects KW - Telomerase -- metabolism KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67858112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Inhibition+of+telomerase+activity+and+induction+of+apoptosis+by+curcumin+in+K-562+cells.&rft.au=Chakraborty%2C+Sutapa%3BGhosh%2C+Utpal%3BBhattacharyya%2C+N+P%3BBhattacharya%2C+R+K%3BRoy%2C+Madhumita&rft.aulast=Chakraborty&rft.aufirst=Sutapa&rft.date=2006-04-11&rft.volume=596&rft.issue=1-2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An Unusual Signal Peptide Extension Inhibits the Binding of Bacterial Presecretory Proteins to the Signal Recognition Particle, Trigger Factor, and the SecYEG Complex AN - 17111219; 6747804 AB - Considerable evidence indicates that the Escherichia coli signal recognition particle (SRP) selectively targets proteins that contain highly hydrophobic signal peptides to the SecYEG complex cotranslationally. Presecretory proteins that contain only moderately hydrophobic signal peptides typically interact with trigger factor (TF) and are targeted post-translationally. Here we describe a striking exception to this rule that has emerged from the analysis of an unusual 55-amino acid signal peptide associated with the E. coli autotransporter EspP. The EspP signal peptide consists of a C-terminal domain that resembles a classical signal peptide plus an N-terminal extension that is conserved in other autotransporter signal peptides. Although a previous study showed that proteins containing the C-terminal domain of the EspP signal peptide are targeted cotranslationally by SRP, we found that proteins containing the full-length signal peptide were targeted post-translationally via a novel TF-independent mechanism. Mutation of an invariant asparagine residue in the N-terminal extension, however, restored cotranslational targeting. Remarkably, proteins containing extremely hydrophobic derivatives of the EspP signal peptide were also targeted post-translationally. These and other results suggest that the N-terminal extension alters the accessibility of the signal peptide to SRP and TF and promotes post-translational export by reducing the efficiency of the interaction between the signal peptide and the SecYEG complex. Based on data, we propose that the N-terminal extension mediates an interaction with an unidentified cytoplasmic factor or induces the formation of an unusual signal peptide conformation prior to the onset of protein translocation. JF - Journal of Biological Chemistry AU - Peterson, Janine H AU - Szabady, Rose L AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0538 Y1 - 2006/04/07/ PY - 2006 DA - 2006 Apr 07 SP - 9038 EP - 9048 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 14 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Protein transport KW - Data processing KW - Post-translation KW - Signal recognition particle KW - Signal peptides KW - Escherichia coli KW - Hydrophobicity KW - trigger factor KW - Mutation KW - Asparagine KW - A 01490:Miscellaneous KW - N 14090:RNA: Ribozymes, Ribonucleoproteins, RNA-binding protein KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17111219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=An+Unusual+Signal+Peptide+Extension+Inhibits+the+Binding+of+Bacterial+Presecretory+Proteins+to+the+Signal+Recognition+Particle%2C+Trigger+Factor%2C+and+the+SecYEG+Complex&rft.au=Peterson%2C+Janine+H%3BSzabady%2C+Rose+L%3BBernstein%2C+Harris+D&rft.aulast=Peterson&rft.aufirst=Janine&rft.date=2006-04-07&rft.volume=281&rft.issue=14&rft.spage=9038&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Data processing; Post-translation; Signal recognition particle; Signal peptides; Hydrophobicity; Asparagine; Mutation; trigger factor; Escherichia coli ER - TY - CPAPER T1 - Clinical Overview of High Temperature Thermal Ablation Techniques and Tools T2 - 2006 Annual Meeting of the Society for Thermal Medicine AN - 40149932; 4153214 JF - 2006 Annual Meeting of the Society for Thermal Medicine AU - Wood, Brad Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 KW - Temperature effects KW - Reviews KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40149932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+Society+for+Thermal+Medicine&rft.atitle=Clinical+Overview+of+High+Temperature+Thermal+Ablation+Techniques+and+Tools&rft.au=Wood%2C+Brad&rft.aulast=Wood&rft.aufirst=Brad&rft.date=2006-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+Society+for+Thermal+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.thermalmedicine.org/meeting06/schedule.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protection from Allergy and Autoimmunity by Helminth-Induced B Cells T2 - 2006 Keystone Symposia on Allergy, Allergic Inflammation and Asthma (D7) AN - 40049226; 4214418 JF - 2006 Keystone Symposia on Allergy, Allergic Inflammation and Asthma (D7) AU - Wilson, Mark S Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 KW - Lymphocytes B KW - Hypersensitivity KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40049226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Allergy%2C+Allergic+Inflammation+and+Asthma+%28D7%29&rft.atitle=Protection+from+Allergy+and+Autoimmunity+by+Helminth-Induced+B+Cells&rft.au=Wilson%2C+Mark+S&rft.aulast=Wilson&rft.aufirst=Mark&rft.date=2006-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Allergy%2C+Allergic+Inflammation+and+Asthma+%28D7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=79 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The IL-21 Receptor Augments TH2 Effector Functions and Alternative Macrophage Activation T2 - 2006 Keystone Symposia on Allergy, Allergic Inflammation and Asthma (D7) AN - 39961554; 4214441 JF - 2006 Keystone Symposia on Allergy, Allergic Inflammation and Asthma (D7) AU - Pesce, John T Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 KW - Interleukin 21 KW - Lymphocytes T KW - Macrophages KW - Cell activation KW - Helper cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Allergy%2C+Allergic+Inflammation+and+Asthma+%28D7%29&rft.atitle=The+IL-21+Receptor+Augments+TH2+Effector+Functions+and+Alternative+Macrophage+Activation&rft.au=Pesce%2C+John+T&rft.aulast=Pesce&rft.aufirst=John&rft.date=2006-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Allergy%2C+Allergic+Inflammation+and+Asthma+%28D7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=79 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Inhibition of Human Acetyl- and Butyrylcholinesterase by Novel Carbamates of (-)- and (+)-Tetrahydrofurobenzofuran and Methanobenzodioxepine AN - 19393812; 7158571 AB - A new enantiomeric synthesis utilizing classical resolution provided two novel series of optically active inhibitors of cholinesterase: (-)- and (+)-O-carbamoyl phenols of tetrahydrofurobenzofuran and methanobenzodioxepine. An additional two series of (-)- and (+)-O-carbamoyl phenols of pyrroloindole and furoindole were obtained by known procedures, and their anticholinesterase actions were similarly quantified against freshly prepared human acetyl- (AChE) and butyrylcholinesterase (BChE). Both enantiomeric forms of each series demonstrated potent cholinesterase inhibitory activity (with IC sub(50) values as low as 10 nM for AChE and 3 nM for BChE), with the exception of the (+)-O-carbamoyl phenols of pyrroloindole, which lacked activity (IC sub(50) values >1 mu M). Based on the biological data of these four series, a structure-activity relationship (SAR) analysis was provided by molecular volume calculations. In addition, a probable transition-state model was established according to the known X-ray structure of a transition-state complex of Torpedo californica AChE-m-(N,N,N-trimethylammonio)-2,2,2-trifluoroacetophenone (TcAChE-TMTFA). This model proved valuable in explaining the enantioselectivity and enzyme subtype selectivity of each series. These carbamates are more potent than, or similarly potent to, anticholinesterases in current clinical use, providing not only inhibitors of potential clinical relevance but also pharmacological tools to define drug-enzyme binding interactions within an enzyme crucial in the maintenance of cognition and numerous systemic physiological functions in health, aging, and disease. JF - Journal of Medicinal Chemistry AU - Luo, W AU - Yu, Q-S AU - Kulkarni, S S AU - Parrish, DA AU - Holloway, H W AU - Tweedie, D AU - Shafferman, A AU - Lahiri, D K AU - Brossi, A AU - Greig, N H AD - Drug Design & Development Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 SP - 2174 EP - 2185 VL - 49 IS - 7 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - Enantiomers KW - Aging KW - Enzymes KW - Cholinesterase KW - Structure-activity relationships KW - Torpedo californica KW - Cognition KW - Phenols KW - Models KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Inhibition+of+Human+Acetyl-+and+Butyrylcholinesterase+by+Novel+Carbamates+of+%28-%29-+and+%28%2B%29-Tetrahydrofurobenzofuran+and+Methanobenzodioxepine&rft.au=Luo%2C+W%3BYu%2C+Q-S%3BKulkarni%2C+S+S%3BParrish%2C+DA%3BHolloway%2C+H+W%3BTweedie%2C+D%3BShafferman%2C+A%3BLahiri%2C+D+K%3BBrossi%2C+A%3BGreig%2C+N+H&rft.aulast=Luo&rft.aufirst=W&rft.date=2006-04-06&rft.volume=49&rft.issue=7&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050578p LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Torpedo californica; Phenols; Cholinesterase; Enzymes; Models; Enantiomers; Cognition; Aging; Structure-activity relationships DO - http://dx.doi.org/10.1021/jm050578p ER - TY - CPAPER T1 - Effect of Pelvic-Floor Exercises, Electrical Stimulation and Biofeedback on Incontinence Rate After Radical Prostatectomy: Preliminary Results of a Prospective Randomized Study T2 - 21st Annual Congress of the European Association of Urology (EAU 2006) AN - 39186391; 4164845 JF - 21st Annual Congress of the European Association of Urology (EAU 2006) AU - Perdona, S AU - Autorino, R AU - Di Lorenzo, G. AU - De Sio, M AU - Marra, L AU - Gallo, L AU - Gallo, A Y1 - 2006/04/05/ PY - 2006 DA - 2006 Apr 05 KW - Radicals KW - Electrical stimuli KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39186391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Congress+of+the+European+Association+of+Urology+%28EAU+2006%29&rft.atitle=Effect+of+Pelvic-Floor+Exercises%2C+Electrical+Stimulation+and+Biofeedback+on+Incontinence+Rate+After+Radical+Prostatectomy%3A+Preliminary+Results+of+a+Prospective+Randomized+Study&rft.au=Perdona%2C+S%3BAutorino%2C+R%3BDi+Lorenzo%2C+G.%3BDe+Sio%2C+M%3BMarra%2C+L%3BGallo%2C+L%3BGallo%2C+A&rft.aulast=Perdona&rft.aufirst=S&rft.date=2006-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Congress+of+the+European+Association+of+Urology+%28EAU+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.uroweb.org/index.php?structure_id=536&Number=&Title=&Author=&Abs tractTopicsID= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monopolar Vs Bipolar TUR: Results of a Randomized Prospective Study T2 - 21st Annual Congress of the European Association of Urology (EAU 2006) AN - 39157615; 4164316 JF - 21st Annual Congress of the European Association of Urology (EAU 2006) AU - Bertolotto, F AU - Raggio, M AU - Vigliercio, G AU - Germinale, F AU - Introini, C Y1 - 2006/04/05/ PY - 2006 DA - 2006 Apr 05 KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39157615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Congress+of+the+European+Association+of+Urology+%28EAU+2006%29&rft.atitle=Monopolar+Vs+Bipolar+TUR%3A+Results+of+a+Randomized+Prospective+Study&rft.au=Bertolotto%2C+F%3BRaggio%2C+M%3BVigliercio%2C+G%3BGerminale%2C+F%3BIntroini%2C+C&rft.aulast=Bertolotto&rft.aufirst=F&rft.date=2006-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Congress+of+the+European+Association+of+Urology+%28EAU+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.uroweb.org/index.php?structure_id=536&Number=&Title=&Author=&Abs tractTopicsID= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effect of long-cycle structured intermittent versus continuous HAART on quality of life in patients with chronic HIV infection. AN - 67765243; 16549967 AB - To examine the effect of repeated, long-cycle structured intermittent versus continuous HAART on health-related quality of life (HRQL) and symptom distress in patients with chronic HIV infection and plasma HIV RNA of less than 50 copies/ml. Prospective survey of adult patients (n = 46) enrolled in a randomized clinical trial evaluating intermittent versus continuous HAART on immunological and virologic parameters. Patients (n = 23) randomized to structured intermittent therapy received serial cycles of 4 weeks on/8 weeks off HAART. HRQL was measured by the physical and mental health summary scores of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Symptom distress was measured by the Symptom Distress Scale. Patients completed initial questionnaires prior to randomization and at weeks 4, 12, and 40 of the trial via a touch screen computer in an outpatient clinic. Baseline demographic and clinical characteristics were equivalent in both treatment groups. Although the mental health summary score declined significantly over time for the structured intermittent group, linear mixed modeling ANOVA indicated no significant difference across time for MOS-HIV summary and Symptom Distress Scale scores between the two treatment arms. In this small sample, repeated long-cycle structured intermittent therapy may not provide HRQL or symptom distress advantage compared to continuous HAART in patients with chronic HIV infection over 10 months of treatment. Further research in a heterogenous chronic HIV population and longer follow-up period is warranted. JF - AIDS (London, England) AU - Powers, April E AU - Marden, Susan F AU - McConnell, Rose AU - Leidy, Nancy K AU - Campbell, Colleen M AU - Soeken, Karen L AU - Barker, Chris AU - Davey, Richard T AU - Dybul, Mark R AD - Nursing and Patient Care Services, National Institutes of Health, Bethesda, Maryland, USA. apowers@niaid.nih.gov Y1 - 2006/04/04/ PY - 2006 DA - 2006 Apr 04 SP - 837 EP - 845 VL - 20 IS - 6 SN - 0269-9370, 0269-9370 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Severity of Illness Index KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Health Status Indicators KW - Drug Administration Schedule KW - Prospective Studies KW - Humans KW - Adult KW - Middle Aged KW - Chronic Disease KW - Antiretroviral Therapy, Highly Active -- methods KW - Psychometrics KW - Male KW - Female KW - HIV Infections -- rehabilitation KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Quality of Life KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67765243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Effect+of+long-cycle+structured+intermittent+versus+continuous+HAART+on+quality+of+life+in+patients+with+chronic+HIV+infection.&rft.au=Powers%2C+April+E%3BMarden%2C+Susan+F%3BMcConnell%2C+Rose%3BLeidy%2C+Nancy+K%3BCampbell%2C+Colleen+M%3BSoeken%2C+Karen+L%3BBarker%2C+Chris%3BDavey%2C+Richard+T%3BDybul%2C+Mark+R&rft.aulast=Powers&rft.aufirst=April&rft.date=2006-04-04&rft.volume=20&rft.issue=6&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague AN - 17128409; 6749525 AB - Yersinia pestis is transmitted by fleas and causes bubonic plague, characterized by severe local lymphadenitis that progresses rapidly to systemic infection and life-threatening septicemia. Here, we show that although flea-borne transmission usually leads to bubonic plague in mice, it can also lead to primary septicemic plague. However, intradermal injection of Y. pestis, commonly used to mimic transmission by fleabite, leads only to bubonic plague. A Y. pestis strain lacking the plasmid-encoded cell-surface plasminogen activator, which is avirulent by intradermal or s.c. injection, was able to cause fatal primary septicemic plague at low incidence, but not bubonic plague, when transmitted by fleas. The results clarify a long-standing uncertainty about the etiology of primary septicemic plague and support an evolutionary scenario in which plague first emerged as a flea-borne septicemic disease of limited transmissibility. Subsequent acquisition of the plasminogen activator gene by horizontal transfer enabled the bubonic form of disease and increased the potential for epidemic spread. JF - Proceedings of the National Academy of Sciences, USA AU - Sebbane, Florent AU - Jarrett, Clayton O AU - Gardner, Donald AU - Long, Daniel AU - Hinnebusch, BJoseph AD - Laboratory of Zoonotic Pathogens and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2006/04/04/ PY - 2006 DA - 2006 Apr 04 SP - 5526 EP - 5530 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 14 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Lymphadenitis KW - Etiology KW - Epidemics KW - Septicemia KW - Disseminated infection KW - Yersinia pestis KW - Plague KW - plasminogen KW - Horizontal transfer KW - Disease transmission KW - J 02855:Human Bacteriology: Others KW - G 07320:Bacterial genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17128409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Role+of+the+Yersinia+pestis+plasminogen+activator+in+the+incidence+of+distinct+septicemic+and+bubonic+forms+of+flea-borne+plague&rft.au=Sebbane%2C+Florent%3BJarrett%2C+Clayton+O%3BGardner%2C+Donald%3BLong%2C+Daniel%3BHinnebusch%2C+BJoseph&rft.aulast=Sebbane&rft.aufirst=Florent&rft.date=2006-04-04&rft.volume=103&rft.issue=14&rft.spage=5526&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Etiology; Lymphadenitis; Epidemics; Septicemia; Disseminated infection; Plague; Horizontal transfer; plasminogen; Disease transmission; Yersinia pestis ER - TY - CPAPER T1 - HIV-1 Budding and Maturation T2 - 158th Meeting of the Society for General Microbiology AN - 39165554; 4160187 JF - 158th Meeting of the Society for General Microbiology AU - Freed, E O Y1 - 2006/04/03/ PY - 2006 DA - 2006 Apr 03 KW - Budding KW - Sexual maturity KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39165554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=158th+Meeting+of+the+Society+for+General+Microbiology&rft.atitle=HIV-1+Budding+and+Maturation&rft.au=Freed%2C+E+O&rft.aulast=Freed&rft.aufirst=E&rft.date=2006-04-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=158th+Meeting+of+the+Society+for+General+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.sgm.ac.uk/meetings/MTGPAGES/Warwick06.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Response of the Black Sea Shelf Ecosystem to Anthropogenic Forcing T2 - 2006 European Geosciences Union General Assembly (EGU 2006) AN - 39979143; 4173019 JF - 2006 European Geosciences Union General Assembly (EGU 2006) AU - Staneva, J AU - Kourafalou, V AU - Stanev, E AU - Tsiaras, K Y1 - 2006/04/02/ PY - 2006 DA - 2006 Apr 02 KW - Black Sea KW - Anthropogenic factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39979143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.atitle=The+Response+of+the+Black+Sea+Shelf+Ecosystem+to+Anthropogenic+Forcing&rft.au=Staneva%2C+J%3BKourafalou%2C+V%3BStanev%2C+E%3BTsiaras%2C+K&rft.aulast=Staneva&rft.aufirst=J&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cosis.net/members/meetings/programme/session_programme.php? m_id=29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lipid Composition Regulates VDAC Channel Voltage Gating T2 - 2006 Keystone Symposia on Metabolomics: From Bioenergetics to Apoptosis (G5) AN - 39894842; 4141995 JF - 2006 Keystone Symposia on Metabolomics: From Bioenergetics to Apoptosis (G5) AU - Rostovtseva, Tatiana K Y1 - 2006/04/02/ PY - 2006 DA - 2006 Apr 02 KW - Channels KW - Lipid composition KW - Channel gating KW - Biochemical composition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Metabolomics%3A+From+Bioenergetics+to+Apoptosis+%28G5%29&rft.atitle=Lipid+Composition+Regulates+VDAC+Channel+Voltage+Gating&rft.au=Rostovtseva%2C+Tatiana+K&rft.aulast=Rostovtseva&rft.aufirst=Tatiana&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Metabolomics%3A+From+Bioenergetics+to+Apoptosis+%28G5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=782 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autophagic Programmed Cell Death by Selective Catalase Degradation T2 - 2006 Keystone Symposia on Metabolomics: From Bioenergetics to Apoptosis (G5) AN - 39783859; 4141984 JF - 2006 Keystone Symposia on Metabolomics: From Bioenergetics to Apoptosis (G5) AU - Yu, Li Y1 - 2006/04/02/ PY - 2006 DA - 2006 Apr 02 KW - Mortality KW - Catalase KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39783859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Metabolomics%3A+From+Bioenergetics+to+Apoptosis+%28G5%29&rft.atitle=Autophagic+Programmed+Cell+Death+by+Selective+Catalase+Degradation&rft.au=Yu%2C+Li&rft.aulast=Yu&rft.aufirst=Li&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Metabolomics%3A+From+Bioenergetics+to+Apoptosis+%28G5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=782 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Intraorbital hematoma after removal of upper third molar: a case report. AN - 85386183; pmid-16546653 JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Warburton, Gary AU - Brahim, Jaime S AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 700 EP - 704 VL - 64 IS - 4 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult KW - *Hematoma: etiology KW - Humans KW - Male KW - *Molar, Third: surgery KW - *Orbital Diseases: etiology KW - Postoperative Hemorrhage: complications KW - Postoperative Hemorrhage: etiology KW - *Tooth Extraction: adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85386183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Intraorbital+hematoma+after+removal+of+upper+third+molar%3A+a+case+report.&rft.au=Warburton%2C+Gary%3BBrahim%2C+Jaime+S&rft.aulast=Warburton&rft.aufirst=Gary&rft.date=2006-04-01&rft.volume=64&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Temporal dissociation of early lexical access and articulation using a delayed naming task--an FMRI study. AN - 85298090; pmid-16049190 AB - Neuroimaging studies of overt speech hold an important practical advantage allowing monitoring of subject performance, particularly valuable in disorders like aphasia. However, speech production is not a monotonic process but a complex sequence of stages. Levelt and colleagues have described these as roughly corresponding to two originally independent systems--conceptual and sensorimotor--that are linked in the formulation and expression of spoken language. In the initial stages a word is chosen to match a concept (lexical selection); in the later stages the sound and motor patterns are encoded and the word is uttered (articulation). It has been difficult to discriminate these stages using conventional neuroimaging techniques. We designed a functional magnetic resonance imaging study in an attempt to do this, by introducing a latency into a conventional naming paradigm, delaying the articulated response. Our results showed that left hemisphere perisylvian areas were active throughout, interacting with visual and heteromodal areas during early lexical access and with motor and auditory areas during overt articulation. These results are consistent with the broadest version of the Levelt model and with that derived from Chomsky's minimalist program in which a core language system interacts with conceptual-intentional systems and articulatory-perceptual systems during the early and late stages of lexical access respectively. JF - Cerebral Cortex AU - Kemeny, Stefan AU - Xu, Jiang AU - Park, Grace H AU - Hosey, Lara A AU - Wettig, Carla M AU - Braun, Allen R AD - Language Section, Voice, Speech and Language Branch, National Institute on Deafness and other Communication Disorders, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA. PY - 2006 SP - 587 EP - 595 VL - 16 IS - 4 SN - 1047-3211, 1047-3211 KW - Cerebral Cortex KW - Magnetic Resonance Imaging KW - Concept Formation KW - Brain Mapping KW - Evoked Potentials KW - Pattern Recognition, Visual KW - Humans KW - Adult KW - Language KW - Speech KW - Male KW - Reaction Time KW - Semantics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85298090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebral+Cortex&rft.atitle=Temporal+dissociation+of+early+lexical+access+and+articulation+using+a+delayed+naming+task--an+FMRI+study.&rft.au=Kemeny%2C+Stefan%3BXu%2C+Jiang%3BPark%2C+Grace+H%3BHosey%2C+Lara+A%3BWettig%2C+Carla+M%3BBraun%2C+Allen+R&rft.aulast=Kemeny&rft.aufirst=Stefan&rft.date=2006-04-01&rft.volume=16&rft.issue=4&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Cerebral+Cortex&rft.issn=10473211&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives. AN - 733228768; 18615126 AB - Paclitaxel is an antineoplastic agent derived from the bark of the western yew, Taxus brevifolia, with a broad spectrum of activity. Because paclitaxel promotes microtubule assembly, neurotoxicity is one of its side effects. Clinical use of paclitaxel has led to peripheral neuropathy and this has been demonstrated to be dependent upon the dose administered, the duration of the infusion, and the schedule of administration. Vehicles in the drug formulation, for example Cremophor in Taxol, have been investigated for their potential to induce peripheral neuropathy. A variety of neuroprotective agents have been tested in animal and clinical studies to prevent paclitaxel neurotoxicity. Recently, novel paclitaxel formulations have been developed to minimize toxicities. This review focuses on recent advances in the etiology of paclitaxel-mediated peripheral neurotoxicity, and discusses current and ongoing strategies for amelioration of this side effect. JF - Current neuropharmacology AU - Scripture, Charity D AU - Figg, William D AU - Sparreboom, Alex AD - Clinical Pharmacology Research Core, National Cancer Institute, Bethesda, MD, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 165 EP - 172 VL - 4 IS - 2 SN - 1570-159X, 1570-159X KW - ABI-007 KW - peripheral neuropathy KW - cremophor KW - Taxol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733228768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+neuropharmacology&rft.atitle=Peripheral+neuropathy+induced+by+paclitaxel%3A+recent+insights+and+future+perspectives.&rft.au=Scripture%2C+Charity+D%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Scripture&rft.aufirst=Charity&rft.date=2006-04-01&rft.volume=4&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Current+neuropharmacology&rft.issn=1570159X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-09 N1 - Date created - 2008-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurocytol. 1984 Oct;13(5):685-701 [6150968] J Cell Biol. 1984 Apr;98(4):1355-62 [6143759] Cancer Clin Trials. 1980 Fall;3(3):211-6 [6254681] Ann Oncol. 1995 May;6(5):489-94 [7669713] Cancer. 1995 Mar 1;75(5):1141-50 [7850713] J Natl Cancer Inst Monogr. 1993;(15):107-15 [7912516] Life Sci. 1994;55(7):519-25 [7913736] J Clin Oncol. 1994 Dec;12(12):2654-66 [7989941] Ann Neurol. 1994 Aug;36(2):221-8 [8053658] Semin Oncol. 1993 Aug;20(4 Suppl 3):1-15 [8102012] J Pharmacol Exp Ther. 1994 Feb;268(2):1051-6 [8113961] Ann N Y Acad Sci. 1993 Aug 27;692:243-5 [8215025] Exp Neurol. 1993 Nov;124(1):73-88 [8282084] Neurology. 1996 Jul;47(1):115-8 [8710063] Gynecol Oncol. 1996 Aug;62(2):166-8 [8751544] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2031-5 [9050899] Cancer Treat Rev. 1997 Mar;23(2):87-95 [9225960] Ital J Neurol Sci. 1997 Apr;18(2):73-9 [9239526] Annu Rev Neurosci. 1979;2:467-504 [94249] Cell Tissue Res. 1998 Feb;291(2):163-74 [9426305] Ann Neurol. 1998 Jan;43(1):46-55 [9450768] N Engl J Med. 1996 Jan 4;334(1):1-6 [7494563] Cancer Chemother Pharmacol. 1995;37(1-2):173-8 [7497589] Drug Saf. 1995 Mar;12(3):196-208 [7619331] Eur J Cancer. 1994;30A(8):1074-7 [7654432] J Neurooncol. 1999 Jan;41(2):107-16 [10222430] J Clin Oncol. 1999 Oct;17(10):3038-47 [10506598] J Clin Oncol. 1999 Oct;17(10):3333-55 [10506637] J Clin Oncol. 1999 Nov;17(11):3403-11 [10550134] J Natl Cancer Inst. 2000 May 3;92(9):699-708 [10793106] Neurotoxicology. 2000 Jun;21(3):389-93 [10894128] Brain Res. 2000 Dec 29;887(2):239-49 [11134612] Invest New Drugs. 2001 May;19(2):125-41 [11392447] Invest New Drugs. 2001 May;19(2):143-53 [11392448] Eur J Cancer. 2001 Sep;37(13):1590-8 [11527683] Ann Oncol. 2001 Aug;12(8):1151-5 [11583199] Pain. 2001 Dec;94(3):293-304 [11731066] J Clin Oncol. 2002 Jan 15;20(2):574-81 [11786588] J Clin Oncol. 1992 Jul;10(7):1165-70 [1376773] Anticancer Drugs. 2003 Nov;14(10):785-92 [14597872] Clin Cancer Res. 2003 Nov 15;9(15):5756-67 [14654561] Clin Cancer Res. 2004 Jan 15;10(2):461-7 [14760066] J Clin Oncol. 2004 Jun 1;22(11):2061-8 [15169793] Clin Cancer Res. 2004 Jun 1;10(11):3708-16 [15173077] Ann Neurol. 1992 Jan;31(1):76-80 [1543351] Neurology. 2005 Jan 11;64(1):26-31 [15642899] J Pharmacol Exp Ther. 1992 May;261(2):803-10 [1578386] Ann N Y Acad Sci. 1975 Jun 30;253:535-44 [167634] Ann Neurol. 1991 Jan;29(1):87-90 [1705109] J Neurocytol. 1986 Aug;15(4):483-96 [2427662] Annu Rev Cell Biol. 1988;4:43-61 [2461722] Neurology. 1989 Mar;39(3):368-73 [2564647] Cancer Res. 1987 May 1;47(9):2486-93 [2882837] Cancer Treat Rep. 1987 Dec;71(12):1171-7 [2891441] Acta Neuropathol. 1988;76(1):17-25 [2899373] Acta Neuropathol. 1988;76(1):26-34 [2899374] N Engl J Med. 1987 Oct 1;317(14):861-6 [3306386] Brain Res. 1981 Aug 3;217(2):392-8 [6113880] Science. 1982 Jul 23;217(4557):377-9 [6124041] Neuroscience. 1983 Oct;10(2):491-509 [6138733] Cancer Res. 1980 May;40(5):1519-24 [6245795] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation. AN - 68626326; 16839211 AB - Programmed cell death or apoptosis is a physiological process by which genetically damaged cells or undesired cells can be eliminated. Various morphological and molecular changes undergoing during the process of apoptosis are the formation of apoptotic blebs of the cell membrane, cell shrinkage, condensation of chromatin and the disruption of deoxyribonucleic acid (DNA) into typical fragments of multiples of 180 base pairs. These changes can be detected in a number of ways. DNA ladder formation, which is observed following gel electrophoresis technique although is widely accepted but does not reflect the DNA breakdown in individual cell and also may miss contributions from small sub-populations in a heterogeneous cell population. Alkaline comet assay as measured by single cell gel electrophoresis, on the other hand, accurately measures DNA fragmentation on a single cell level and allows analysis of subpopulation of cells. The assay was originally developed for measuring DNA damage of cells exposed to any genotoxic agent. However, the comet image generated by an apoptotic cell is different from that obtained with a cell treated for a short time with a genotoxic agent. Correlation of comet formation with various other established parameters of apoptosis is very important. The present study aims to correlate different features of apoptosis with the formation of comet tail in human leukemia K-562 cells using tea extracts. Apoptosis as measured by formation of apoptotic bodies, flow cytometric analysis, activation of caspase 3 and 8, and expressions of apoptosis related genes such as bcl-2 and bax showed high degree of correlation with comet tail moment. This indicates that comet assay can accurately reflect measure of DNA fragmentation and hence can be used to detect a cell undergoing apoptosis. JF - Asian Pacific journal of cancer prevention : APJCP AU - Chakraborty, Sutapa AU - Kundu, Trina AU - Dey, Subhabrata AU - Bhattacharya, Rathin K AU - Siddiqi, Maqsood AU - Roy, Madhumita AD - Environmental Carcinogenesis and Toxicology Department, Chittaranjan, National Cancer Institute, Kolkata 700 026, India. PY - 2006 SP - 201 EP - 207 VL - 7 IS - 2 SN - 1513-7368, 1513-7368 KW - Apoptosis Regulatory Proteins KW - 0 KW - Plant Extracts KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Apoptosis Regulatory Proteins -- metabolism KW - Cell Culture Techniques KW - Flow Cytometry KW - K562 Cells KW - Comet Assay KW - Apoptosis KW - Camellia sinensis KW - Leukemia, Erythroblastic, Acute -- pathology KW - Leukemia, Erythroblastic, Acute -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68626326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Tea-induced+apoptosis+in+human+leukemia+K562+cells+as+assessed+by+comet+formation.&rft.au=Chakraborty%2C+Sutapa%3BKundu%2C+Trina%3BDey%2C+Subhabrata%3BBhattacharya%2C+Rathin+K%3BSiddiqi%2C+Maqsood%3BRoy%2C+Madhumita&rft.aulast=Chakraborty&rft.aufirst=Sutapa&rft.date=2006-04-01&rft.volume=7&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is interferon-alpha and retinoic acid combination along with radiation superior to chemo-radiation in the treatment of advanced carcinoma of cervix? AN - 68571210; 16790941 AB - Locally advanced cervical cancers comprise a large majority of the gynecologic cancers in India and other developing countries. Concurrent chemo-radiation has improved the survival of high risk stage I and stage II cervical cancers. There is no evidence that the same survival benefit has been achieved with chemo-radiation in stage III and stage IV disease. Interferon-alpha and Retinoic acid have synergistic anti-proliferative activity. In combination with radiation, they substantially enhance the sensitivity of the squamous carcinoma cells to radiation. Based on these observations from the in vitro studies, a few clinical trials have evaluated the combination of interferon-alpha and Retinoic acid, concomitant with radiation, to treat cervical cancers. The results from these early trials were encouraging and the combination had minimal toxicities. However, till date, no phase III randomized controlled trial has been done to evaluate this therapeutic modality. JF - Indian journal of cancer AU - Basu, P AU - Biswas, J AU - Mandal, R AU - Choudhury, P AD - Department of Gynecologic Oncology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, India. ceds@vsnl.com PY - 2006 SP - 54 EP - 59 VL - 43 IS - 2 SN - 0019-509X, 0019-509X KW - Interferon-alpha KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Interferon-alpha -- administration & dosage KW - Combined Modality Therapy KW - Humans KW - Tretinoin -- administration & dosage KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Female KW - Uterine Cervical Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Uterine Cervical Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68571210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+cancer&rft.atitle=Is+interferon-alpha+and+retinoic+acid+combination+along+with+radiation+superior+to+chemo-radiation+in+the+treatment+of+advanced+carcinoma+of+cervix%3F&rft.au=Basu%2C+P%3BBiswas%2C+J%3BMandal%2C+R%3BChoudhury%2C+P&rft.aulast=Basu&rft.aufirst=P&rft.date=2006-04-01&rft.volume=43&rft.issue=2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+cancer&rft.issn=0019509X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Getting it right: being smarter about clinical trials. AN - 68190772; 16608383 JF - PLoS medicine AU - Kramer, Barnett S AU - Wilentz, Joan AU - Alexander, Duane AU - Burklow, John AU - Friedman, Lawrence M AU - Hodes, Richard AU - Kirschstein, Ruth AU - Patterson, Amy AU - Rodgers, Griffin AU - Straus, Stephen E Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1 VL - 3 IS - 6 KW - Biomarkers KW - 0 KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Endpoint Determination -- methods KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Information Dissemination KW - Health Policy KW - Biomarkers -- analysis KW - Confounding Factors (Epidemiology) KW - Data Interpretation, Statistical KW - Guidelines as Topic KW - Bias (Epidemiology) KW - Time Factors KW - Meta-Analysis as Topic KW - Genomics KW - Research Design KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68190772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=PLoS+medicine&rft.atitle=Getting+it+right%3A+being+smarter+about+clinical+trials.&rft.au=Kramer%2C+Barnett+S%3BWilentz%2C+Joan%3BAlexander%2C+Duane%3BBurklow%2C+John%3BFriedman%2C+Lawrence+M%3BHodes%2C+Richard%3BKirschstein%2C+Ruth%3BPatterson%2C+Amy%3BRodgers%2C+Griffin%3BStraus%2C+Stephen+E&rft.aulast=Kramer&rft.aufirst=Barnett&rft.date=2006-04-01&rft.volume=3&rft.issue=6&rft.spage=e144&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Mar 8;283(10):1295-302 [10714728] Nat Rev Cancer. 2005 Feb;5(2):142-9 [15685197] JAMA. 2002 Jul 17;288(3):321-33 [12117397] South Med J. 2002 Aug;95(8):795-7 [12190211] N Engl J Med. 2003 Jul 17;349(3):215-24 [12824459] Ann Intern Med. 2004 Feb 3;140(3):226-8 [14757622] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] J Natl Cancer Inst. 2005 Feb 16;97(4):315-9 [15713968] N Engl J Med. 2005 Mar 31;352(13):1285-7 [15800222] PLoS Med. 2004 Nov;1(2):e35 [15578106] JAMA. 2005 Jul 6;294(1):47-55 [15998890] JAMA. 2005 Jul 6;294(1):66-70 [15998892] Lancet. 2005 Jul 9-15;366(9480):107-8 [16005318] JAMA. 2004 May 26;291(20):2457-65 [15161896] BMJ. 2004 Jun 19;328(7454):1490 [15205295] Int J Epidemiol. 2004 Jun;33(3):457-9 [15166202] Dis Markers. 2004;20(2):97-102 [15322317] JAMA. 2004 Sep 22;292(12):1426-7; author reply 1427 [15383505] Ann Intern Med. 1980 Sep;93(3):391-8 [6776858] Stat Med. 1989 Apr;8(4):431-40 [2727467] J Natl Cancer Inst. 1993 Sep 15;85(18):1483-92 [8360931] N Engl J Med. 1993 Sep 30;329(14):977-86 [8366922] N Engl J Med. 1994 Apr 14;330(15):1029-35 [8127329] Circulation. 1994 Oct;90(4):1765-73 [7923660] N Engl J Med. 1996 May 2;334(18):1145-9 [8602179] N Engl J Med. 1996 May 2;334(18):1150-5 [8602180] N Engl J Med. 1996 May 23;334(21):1349-55 [8614419] Lancet. 1997 Feb 8;349(9049):375-80 [9033462] N Engl J Med. 1997 Aug 21;337(8):536-42 [9262498] Lancet. 1999 Jan 2;353(9146):9-13 [10023943] BMJ. 2000 Jul 29;321(7256):255-6 [10915111] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of methylphenidate dependence syndrome in psychiatric hospital settings. AN - 68027194; 16734276 AB - The characteristics of methylphenidate (MPD) cases reported in a nationwide mental hospital survey on substance-related psychiatric disorders are studied compared to methamphetamine cases. Although the two groups did not differ in terms of age and sex, the MPD group revealed longer educational histories and lower antisocial traits. About half of the MPD group had a history of methamphetamine use and 30% had used the substance as the initial substance of abuse. They exhibited a general tendency toward multiple substance use. These results indicate that a significant number of MPD cases exist who used MPD as a substance alternative to methamphetamine and also suggest that they may potentially have a tendency to develop abuse or dependence. The MPD cases most likely had a psychiatric diagnosis of "Dependence syndrome (F15.2)," according to the ICD-10 guidelines. The SDS scores also indicated a more severe dependence syndrome, particularly psychological dependence, which they may possibly develop more quickly. An abundance of information for MPD abusers to utilize is available through the internet, including the pharmacological properties, such as increased sensation or elation through MPD intake and how and where to easily acquire the substance. They may even forge a prescription to obtain MPD. This behavior can be recognized as "substance-seeking behavior" in behavioral pharmacology terms, accompanied by craving based on psychological dependence on the substance, and can be very difficult to control. Little evidence exists regarding the effectiveness and necessity of MPD as a treatment for depression, and thus MPD prescriptions must be carefully considered by psychiatrists or physicians. The application of MPD as an antidepressant in the health insurance system must be re-examined as well. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Ozaki, Shigeru AU - Wada, Kiyoshi AD - Department of Drug Dependence Research, National Institute of Mental Health, National Center for Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8553, Japan. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 89 EP - 99 VL - 41 IS - 2 SN - 1341-8963, 1341-8963 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Methamphetamine -- adverse effects KW - Humans KW - Adult KW - Male KW - Female KW - Methylphenidate -- adverse effects KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68027194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=Characteristics+of+methylphenidate+dependence+syndrome+in+psychiatric+hospital+settings.&rft.au=Ozaki%2C+Shigeru%3BWada%2C+Kiyoshi&rft.aulast=Ozaki&rft.aufirst=Shigeru&rft.date=2006-04-01&rft.volume=41&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-04 N1 - Date created - 2006-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of association between acute exposure to ionizing radiation and liver cirrhosis. AN - 67965489; 16690591 AB - Although previous studies have shown significantly increased risks of liver cirrhosis and chronic liver disease for acute radiation exposure among survivors of the atomic bombings of Hiroshima and Nagasaki, Japan, these studies have not taken into account hepatitis B virus (HBV) infections. Because HBV is associated with both A-bomb radiation and liver cirrhosis, our goal was to investigate the relationship of acute ionizing radiation to liver cirrhosis adjusting for HBV, co-occurring primary liver cancer (PLC), and other potential confounders. Using a cross-sectional design and pathology review of a cohort of Japanese atomic-bomb survivors, we found that 213 of 335 (63.6%) subjects with PLC and 55 of 776 (7.1%) subjects without PLC had cirrhosis. We found no association between acute exposure to A-bomb radiation and liver cirrhosis. The adjusted odds ratio of cirrhosis per Sv liver irradiation was 0.59 (95% confidence interval: 0.27 - 1.27). Cirrhosis risks for the highest tertile of radiation exposure (mean exposure 0.7 Sv) were also not elevated (0.8, 0.26 - 2.12 and 0.2, 0.03 - 0.98 among subjects with and without PLC. Acute exposure to liver irradiation does not increase risks of liver cirrhosis, regardless of PLC status. JF - International journal of radiation biology AU - Sharp, Gerald B AU - Mizuno, Terumi AU - Fukuhara, Toshiyuki AU - Tokuoka, Shoji AD - Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan. gsharp@niaid.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 231 EP - 240 VL - 82 IS - 4 SN - 0955-3002, 0955-3002 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Hepatitis C -- mortality KW - Body Burden KW - Humans KW - Retrospective Studies KW - Smoking -- epidemiology KW - Comorbidity KW - Japan -- epidemiology KW - Cross-Sectional Studies KW - Relative Biological Effectiveness KW - Risk Factors KW - Cohort Studies KW - Incidence KW - Statistics as Topic KW - Hepatitis B -- mortality KW - Female KW - Male KW - Survivors -- statistics & numerical data KW - Environmental Exposure -- statistics & numerical data KW - Risk Assessment -- methods KW - Liver Cirrhosis -- mortality KW - Nuclear Warfare -- statistics & numerical data KW - Radiation, Ionizing KW - Radiation Injuries -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67965489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+biology&rft.atitle=Lack+of+association+between+acute+exposure+to+ionizing+radiation+and+liver+cirrhosis.&rft.au=Sharp%2C+Gerald+B%3BMizuno%2C+Terumi%3BFukuhara%2C+Toshiyuki%3BTokuoka%2C+Shoji&rft.aulast=Sharp&rft.aufirst=Gerald&rft.date=2006-04-01&rft.volume=82&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+biology&rft.issn=09553002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of portal vein tumor thrombosis of hepatoma patients with either stereotactic radiotherapy or three-dimensional conformal radiotherapy. AN - 67953865; 16613896 AB - Patients with hepatocellular carcinoma (HCC) often have unresectable tumors. Transcatheter arterial chemoembolization (TACE) is one of the limited alternative treatments that can prolong these patients' survival. However, the presence of portal vein tumor thrombosis (PVTT) is a contraindication for TACE and, therefore, HCC patients with PVTT would be depleted of the advantage of TACE. The purpose of this study was to analyze the recanalization rate of thrombosed portal vein and treatment toxicities after stereotactic radiotherapy (SRT) or three-dimensional conformal radiotherapy (3DCRT). From March 2002 to November 2004, 43 patients were enrolled in this prospective study. Twenty-two patients were in the SRT group and 21 in the 3DCRT group. For SRT, 3 Gy per fraction, 3 fractions per week, was given to a total dose of 45 Gy. For 3DCRT, a daily dose of 1.8 Gy, 5 fractions per week, was given to a total dose of 45 Gy. Of the 43 patients, 16 completed the planned radiotherapy. Eventually, 14 patients received evaluation for portal vein recanalization, 8 in the SRT and 6 in the 3DCRT group, respectively. For all patients, the crude response rate was 26%. For 14 evaluable patients, the crude response rate was 79%. It was 75% in the SRT group and 83% in the 3DCRT group (P = 0.71). The median survival time was 6.0 and 6.7 months for the SRT and 3DCRT group, respectively (P = 0.911). Image-based radiotherapy, either SRT or 3DCRT, can recanalize the PVTT in unresectable HCC patients. Responders also had better 1 year and 2 year survivals. A more strict patient selection criterion may maximize the potential benefits of radiotherapy for hepatoma patients with PVTT. JF - Japanese journal of clinical oncology AU - Lin, Chun-Shu AU - Jen, Yee-Min AU - Chiu, Su-Yun AU - Hwang, Jing-Min AU - Chao, Hsing-Lung AU - Lin, Hon-Yi AU - Shum, Weng-Yoon AD - Department of Radiation Oncology, Tri-Service General Hospital, 325 Section 2 Cheng-Kong Rd., Nei-Hu 11490, Taipei, Taiwan, ROC. bookslin.tw@yahoo.com.tw Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 212 EP - 217 VL - 36 IS - 4 SN - 0368-2811, 0368-2811 KW - Index Medicus KW - Imaging, Three-Dimensional KW - Prospective Studies KW - Survival Rate KW - Dose Fractionation KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Liver Neoplasms -- radiotherapy KW - Neoplastic Cells, Circulating -- radiation effects KW - Liver Neoplasms -- pathology KW - Neoplastic Cells, Circulating -- pathology KW - Radiotherapy, Conformal -- methods KW - Portal Vein -- pathology KW - Liver Neoplasms -- mortality KW - Carcinoma, Hepatocellular -- radiotherapy KW - Carcinoma, Hepatocellular -- pathology KW - Carcinoma, Hepatocellular -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67953865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+clinical+oncology&rft.atitle=Treatment+of+portal+vein+tumor+thrombosis+of+hepatoma+patients+with+either+stereotactic+radiotherapy+or+three-dimensional+conformal+radiotherapy.&rft.au=Lin%2C+Chun-Shu%3BJen%2C+Yee-Min%3BChiu%2C+Su-Yun%3BHwang%2C+Jing-Min%3BChao%2C+Hsing-Lung%3BLin%2C+Hon-Yi%3BShum%2C+Weng-Yoon&rft.aulast=Lin&rft.aufirst=Chun-Shu&rft.date=2006-04-01&rft.volume=36&rft.issue=4&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+clinical+oncology&rft.issn=03682811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-14 N1 - Date created - 2006-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations. AN - 67919089; 16648579 AB - The ability of the farnesyl transferase inhibitor R115777 to act as a cancer therapeutic/preventive agent and to modulate proliferation/apoptosis markers was determined in the methylnitrosourea-induced model of mammary carcinogenesis. Female Sprague-Dawley rats were given methylnitrosourea at 50 days of age. In the prevention study, R115777 (5, 16, or 50 mg/kg body weight/d), beginning 5 days after methylnitrosourea treatment, decreased the formation of mammary cancers by 6%, 42%, and 75%, respectively. Approximately 50% of the mammary cancers that developed had HaRas mutations. Only 1 of 15 tumors that grew out in the presence of R115777 (16 or 50 mg/kg body weight/d) had a HaRas mutation. In the therapeutic study, a surgical biopsy of a mammary cancer was done to determine HaRas status, and growth of the cancer was then followed during treatment of the rat with R115777. Virtually every cancer with a HaRas mutation underwent complete regression within 3 weeks, whereas tumors without a HaRas mutation had variable responses to the inhibitor. Both of these studies implied a high sensitivity of tumors with HaRas mutations to the effects of R115777. In order to understand the preferential susceptibility of tumors with HaRas mutations, rats with a palpable cancer were treated with R115777 for a period of 36 or 96 hours prior to sacrifice, and the proliferation and apoptosis levels in the cancers were determined. The proliferative index was significantly (>85%) decreased in all mammary cancers with HaRas mutations, whereas variable responses were observed in cancers without HaRas mutations. Apoptosis was also measured and a 5-fold increase was observed in HaRas mutant tumors, again with varying responses in the HaRas wild-type cancers. Thus, R115777 was active in the prevention and therapy of these chemically induced mammary cancers, but was strikingly more effective in cancers with HaRas mutations. JF - Molecular cancer therapeutics AU - Lubet, Ronald A AU - Christov, Konstantin AU - You, Ming AU - Yao, Ruisheng AU - Steele, Vernon E AU - End, David W AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA. lubetr@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1073 EP - 1078 VL - 5 IS - 4 SN - 1535-7163, 1535-7163 KW - Anticarcinogenic Agents KW - 0 KW - Antimutagenic Agents KW - Carcinogens KW - Enzyme Inhibitors KW - Quinolones KW - Methylnitrosourea KW - 684-93-5 KW - Farnesyltranstransferase KW - EC 2.5.1.29 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Methylnitrosourea -- pharmacology KW - Apoptosis -- drug effects KW - Cell Division -- drug effects KW - Female KW - Antimutagenic Agents -- pharmacology KW - Genes, ras -- drug effects KW - Farnesyltranstransferase -- antagonists & inhibitors KW - Anticarcinogenic Agents -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Mammary Neoplasms, Experimental -- prevention & control KW - Quinolones -- pharmacology KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67919089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Effects+of+the+farnesyl+transferase+inhibitor+R115777+%28Zarnestra%29+on+mammary+carcinogenesis%3A+prevention%2C+therapy%2C+and+role+of+HaRas+mutations.&rft.au=Lubet%2C+Ronald+A%3BChristov%2C+Konstantin%3BYou%2C+Ming%3BYao%2C+Ruisheng%3BSteele%2C+Vernon+E%3BEnd%2C+David+W%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2006-04-01&rft.volume=5&rft.issue=4&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. AN - 67917675; 16648555 AB - Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis and tumor phenotype. We used a panel of 60 human cancer cell lines (the NCI-60) as a model system to identify relationships among DNA copy number, mRNA expression level, and drug sensitivity. For each of 64 cancer-relevant genes, we calculated all 4,096 possible Pearson's correlation coefficients relating DNA copy number (assessed by comparative genomic hybridization using bacterial artificial chromosome microarrays) and mRNA expression level (determined using both cDNA and Affymetrix oligonucleotide microarrays). The analysis identified an association of ERBB2 overexpression with 3p copy number, a finding supported by data from human tumors and a mouse model of ERBB2-induced carcinogenesis. When we examined the correlation between DNA copy number for all 353 unique loci on the bacterial artificial chromosome microarray and drug sensitivity for 118 drugs with putatively known mechanisms of action, we found a striking negative correlation (-0.983; 95% bootstrap confidence interval, -0.999 to -0.899) between activity of the enzyme drug L-asparaginase and DNA copy number of genes near asparagine synthetase in the ovarian cancer cells. Previous analysis of drug sensitivity and mRNA expression had suggested an inverse relationship between mRNA levels of asparagine synthetase and L-asparaginase sensitivity in the NCI-60. The concordance of pharmacogenomic findings at the DNA and mRNA levels strongly suggests further study of L-asparaginase for possible treatment of a low-synthetase subset of clinical ovarian cancers. The DNA copy number database presented here will enable other investigators to explore DNA transcript-drug relationships in their own domains of research focus. JF - Molecular cancer therapeutics AU - Bussey, Kimberly J AU - Chin, Koei AU - Lababidi, Samir AU - Reimers, Mark AU - Reinhold, William C AU - Kuo, Wen-Lin AU - Gwadry, Fuad AU - Ajay AU - Kouros-Mehr, Hosein AU - Fridlyand, Jane AU - Jain, Ajay AU - Collins, Colin AU - Nishizuka, Satoshi AU - Tonon, Giovanni AU - Roschke, Anna AU - Gehlhaus, Kristen AU - Kirsch, Ilan AU - Scudiero, Dominic A AU - Gray, Joe W AU - Weinstein, John N AD - Laboratory of Molecular Pharmacology, National Cancer Institute, Building 37, Room 5056, NIH, MSC 4255, 9000 Rockville Pike, Bethesda, MD 20892-4255, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 853 EP - 867 VL - 5 IS - 4 SN - 1535-7163, 1535-7163 KW - Antineoplastic Agents KW - 0 KW - DNA, Neoplasm KW - Neoplasm Proteins KW - RNA, Messenger KW - RNA, Neoplasm KW - Index Medicus KW - Phenotype KW - Karyotyping KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Nucleic Acid Hybridization KW - Antineoplastic Agents -- pharmacology KW - Gene Expression Regulation, Neoplastic KW - DNA, Neoplasm -- drug effects KW - RNA, Neoplasm -- drug effects KW - RNA, Messenger -- drug effects KW - Neoplasm Proteins -- genetics KW - DNA, Neoplasm -- genetics KW - Cell Line, Tumor -- drug effects KW - RNA, Neoplasm -- genetics KW - RNA, Messenger -- genetics KW - Cell Line, Tumor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67917675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Integrating+data+on+DNA+copy+number+with+gene+expression+levels+and+drug+sensitivities+in+the+NCI-60+cell+line+panel.&rft.au=Bussey%2C+Kimberly+J%3BChin%2C+Koei%3BLababidi%2C+Samir%3BReimers%2C+Mark%3BReinhold%2C+William+C%3BKuo%2C+Wen-Lin%3BGwadry%2C+Fuad%3BAjay%3BKouros-Mehr%2C+Hosein%3BFridlyand%2C+Jane%3BJain%2C+Ajay%3BCollins%2C+Colin%3BNishizuka%2C+Satoshi%3BTonon%2C+Giovanni%3BRoschke%2C+Anna%3BGehlhaus%2C+Kristen%3BKirsch%2C+Ilan%3BScudiero%2C+Dominic+A%3BGray%2C+Joe+W%3BWeinstein%2C+John+N&rft.aulast=Bussey&rft.aufirst=Kimberly&rft.date=2006-04-01&rft.volume=5&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 1999 Dec;5(12):4140-5 [10632352] Science. 1997 Jan 17;275(5298):343-9 [8994024] Nat Genet. 2000 Mar;24(3):227-35 [10700174] Nat Genet. 2000 Mar;24(3):236-44 [10700175] J Biol Chem. 2000 Oct 27;275(43):33449-56 [10938281] Mol Carcinog. 2000 Nov;29(3):151-8 [11108660] Eur J Cancer. 2001 Jun;37(9):1089-95 [11378338] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10787-92 [11553813] Nat Genet. 2001 Nov;29(3):263-4 [11687795] Cancer Res. 2001 Nov 15;61(22):8143-9 [11719443] Genome Res. 2002 Feb;12(2):325-32 [11827952] EMBO J. 2002 Mar 15;21(6):1456-64 [11889051] Cancer Res. 2002 Mar 15;62(6):1688-95 [11912141] Cancer Res. 2002 Jul 1;62(13):3636-40 [12097266] Hum Pathol. 2002 Jun;33(6):632-41 [12152163] Pharmacogenomics J. 2002;2(4):259-71 [12196914] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12963-8 [12297621] Cancer Res. 2002 Nov 1;62(21):6240-5 [12414653] Genome Biol. 2003;4(4):R27 [12702208] Genome Biol. 2003;4(4):R28 [12702209] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] Cancer Res. 2003 Sep 1;63(17):5243-50 [14500354] Cancer Res. 2003 Sep 1;63(17):5266-73 [14500357] Cancer Genet Cytogenet. 2003 Nov;147(1):28-35 [14580768] Mol Cell Biochem. 2003 Nov;253(1-2):41-7 [14619954] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14229-34 [14623978] Genome Biol. 2003;4(12):R82 [14659019] Cancer Res. 2003 Dec 15;63(24):8634-47 [14695175] Chem Pharm Bull (Tokyo). 2004 Jan;52(1):1-26 [14709862] Cell Struct Funct. 1999 Oct;24(5):329-35 [15216890] Annu Rev Pharmacol. 1970;10:421-40 [4911021] Annu Rev Med. 1970;21:433-44 [4913953] Prog Clin Biol Res. 1988;276:265-86 [3051021] J Natl Cancer Inst. 1989 Nov 15;81(22):1704-9 [2572702] Cancer Res. 1991 Aug 1;51(15):4045-51 [1677312] Science. 1992 Oct 16;258(5081):447-51 [1411538] Cancer Genet Cytogenet. 1993 Jun;67(2):123-5 [8330268] Anticancer Res. 1994 Jan-Feb;14(1B):261-7 [8166465] EMBO J. 1995 Sep 15;14(18):4514-22 [7556094] Oncogene. 1996 Oct 17;13(8):1815-8 [8895529] Electrophoresis. 1997 Mar-Apr;18(3-4):391-402 [9150917] Electrophoresis. 1997 Mar-Apr;18(3-4):647-53 [9150955] Oncogene. 1997 Jun 19;14(24):2979-84 [9205105] Cancer Res. 1997 Aug 15;57(16):3520-5 [9270023] Oncogene. 1998 Jul 16;17(2):207-12 [9674705] Nat Genet. 1998 Oct;20(2):207-11 [9771718] J Biol Chem. 1999 Jan 1;274(1):67-74 [9867812] Cancer Res. 1999 Jun 15;59(12):2759-65 [10383126] Clin Cancer Res. 2000 Jan;6(1):112-26 [10656439] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis. AN - 67904596; 16641528 AB - p53 as a key molecular node in the stress response pathway, including inflammation. p53 is involved in several critical pathways including cell cycle arrest, apoptosis, DNA repair, and cellular senescence, which are essential for normal cellular homeostasis and maintaining genome integrity. The alteration of the TP53 gene or posttranslational modification in the p53 protein can alter its response to cellular stress. The molecular archaeology of the TP53 mutation spectrum generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the TP53 gene implicates environmental carcinogens, and both endogenous agents and processes in the etiology of human cancer. JF - Journal of Nippon Medical School = Nippon Ika Daigaku zasshi AU - Hussain, S Perwez AU - Harris, Cutis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 54 EP - 64 VL - 73 IS - 2 SN - 1345-4676, 1345-4676 KW - Tumor Suppressor Protein p53 KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - DNA Repair -- physiology KW - Oxidative Stress -- physiology KW - Humans KW - Cell Cycle -- physiology KW - Apoptosis -- physiology KW - Genes, p53 -- genetics KW - Nitric Oxide -- physiology KW - Tumor Suppressor Protein p53 -- physiology KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67904596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nippon+Medical+School+%3D+Nippon+Ika+Daigaku+zasshi&rft.atitle=p53+biological+network%3A+at+the+crossroads+of+the+cellular-stress+response+pathway+and+molecular+carcinogenesis.&rft.au=Hussain%2C+S+Perwez%3BHarris%2C+Cutis+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2006-04-01&rft.volume=73&rft.issue=2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nippon+Medical+School+%3D+Nippon+Ika+Daigaku+zasshi&rft.issn=13454676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Balancing efficacy and safety in the use of oral sedation in dental outpatients. AN - 67904134; 16637480 AB - Concerns about the safety of pediatric oral sedation and the incremental use of triazolam in adults prompted a workshop cosponsored by several professional organizations. There is a strong need and demand for adult and pediatric sedation services. Using oral medication to achieve anxiolysis in adults appears to have a wide margin of safety. Mortality and serious morbidity, however, have been reported with oral conscious sedation, especially in young children. Most serious adverse events are related to potentially avoidable respiratory complications. Clinical trials are needed to evaluate oral sedative drugs and combinations, as well as to develop discharge criteria with objective quantifiable measures of home readiness. Courses devoted to airway management should be developed for dentists who provide conscious sedation services. State regulation of enteral administration of sedatives to achieve conscious sedation is needed to ensure safety. Safety in outpatient sedation is of paramount concern, with enteral administration of benzodiazepines appearing safe but poorly documented in the office setting. Conscious sedation by the enteral route, including incremental triazolam, necessitates careful patient evaluation, monitoring, documentation, facilities, equipment and personnel as described in American Dental Association and American Academy of Pediatric Dentistry guidelines. JF - Journal of the American Dental Association (1939) AU - Dionne, Raymond A AU - Yagiela, John A AU - Coté, Charles J AU - Donaldson, Mark AU - Edwards, Michael AU - Greenblatt, David J AU - Haas, Daniel AU - Malviya, Shobha AU - Milgrom, Peter AU - Moore, Paul A AU - Shampaine, Guy AU - Silverman, Michael AU - Williams, Roger L AU - Wilson, Stephen AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, USA. dionner@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 502 EP - 513 VL - 137 IS - 4 SN - 0002-8177, 0002-8177 KW - Anti-Anxiety Agents KW - 0 KW - Triazolam KW - 1HM943223R KW - Dentistry KW - Index Medicus KW - Humans KW - Adult KW - Child KW - Dental Anxiety -- drug therapy KW - Anesthesia, Dental -- adverse effects KW - Anti-Anxiety Agents -- administration & dosage KW - Triazolam -- administration & dosage KW - Triazolam -- pharmacokinetics KW - Conscious Sedation -- adverse effects KW - Anti-Anxiety Agents -- adverse effects KW - Anti-Anxiety Agents -- pharmacokinetics KW - Anesthesia, Dental -- methods KW - Triazolam -- adverse effects KW - Dental Care for Children -- methods KW - Conscious Sedation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67904134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Balancing+efficacy+and+safety+in+the+use+of+oral+sedation+in+dental+outpatients.&rft.au=Dionne%2C+Raymond+A%3BYagiela%2C+John+A%3BCot%C3%A9%2C+Charles+J%3BDonaldson%2C+Mark%3BEdwards%2C+Michael%3BGreenblatt%2C+David+J%3BHaas%2C+Daniel%3BMalviya%2C+Shobha%3BMilgrom%2C+Peter%3BMoore%2C+Paul+A%3BShampaine%2C+Guy%3BSilverman%2C+Michael%3BWilliams%2C+Roger+L%3BWilson%2C+Stephen&rft.aulast=Dionne&rft.aufirst=Raymond&rft.date=2006-04-01&rft.volume=137&rft.issue=4&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-05 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2006 Jul;137(7):944, 946; author reply 946 [16803818] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil. AN - 67899259; 16510790 AB - RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to the nucleotide-depleting drug 6-azauracil (6AU). In this work we reisolated the rpo21-24/rpb1-E1230K allele, which reduces the interaction of RNAPII-TFIIS, and identified five new point mutations in RPB1 that cause hypersensitivity to 6AU. The novel mutants affect highly conserved residues of Rpb1 and have differential genetic and biochemical effects. Three of the mutations affect the "lid" and "rudder," two small loops suggested by structural studies to play a central role in the separation of the RNA-DNA hybrids. Most interestingly, two mutations affecting the catalytic center (rpb1-N488D) and the homology box G (rpb1-E1103G) have strong opposite effects on the intrinsic in vitro polymerization rate of RNAPII. Moreover, the synthetic interactions of these mutants with soh1, spt4, and dst1 suggest differential in vivo effects. JF - Genetics AU - Malagon, Francisco AU - Kireeva, Maria L AU - Shafer, Brenda K AU - Lubkowska, Lucyna AU - Kashlev, Mikhail AU - Strathern, Jeffrey N AD - Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 2201 EP - 2209 VL - 172 IS - 4 SN - 0016-6731, 0016-6731 KW - Antimetabolites KW - 0 KW - Peptides KW - RNA, Messenger KW - Saccharomyces cerevisiae Proteins KW - Uracil KW - 56HH86ZVCT KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - RNA Polymerase II KW - EC 2.7.7.- KW - RPB1 protein, S cerevisiae KW - azauracil KW - I14TWN70LR KW - Index Medicus KW - Antimetabolites -- pharmacology KW - RNA, Messenger -- metabolism KW - Point Mutation KW - Molecular Sequence Data KW - Catalytic Domain KW - Peptides -- chemistry KW - DNA -- chemistry KW - RNA -- chemistry KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Saccharomyces cerevisiae -- genetics KW - RNA Polymerase II -- metabolism KW - Uracil -- analogs & derivatives KW - RNA Polymerase II -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - RNA Polymerase II -- chemistry KW - Uracil -- pharmacology KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67899259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Mutations+in+the+Saccharomyces+cerevisiae+RPB1+gene+conferring+hypersensitivity+to+6-azauracil.&rft.au=Malagon%2C+Francisco%3BKireeva%2C+Maria+L%3BShafer%2C+Brenda+K%3BLubkowska%2C+Lucyna%3BKashlev%2C+Mikhail%3BStrathern%2C+Jeffrey+N&rft.aulast=Malagon&rft.aufirst=Francisco&rft.date=2006-04-01&rft.volume=172&rft.issue=4&rft.spage=2201&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-17 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2001 Jun 8;292(5523):1863-76 [11313498] Science. 2004 Feb 13;303(5660):983-8 [14963322] EMBO J. 2002 Feb 1;21(3):195-201 [11823412] Trends Biochem Sci. 2002 Feb;27(2):107-9 [11852249] J Biol Chem. 2002 Jun 14;277(24):22103-6 [11934891] Nature. 2002 Jun 13;417(6890):712-9 [12000971] Biochim Biophys Acta. 2002 Sep 13;1577(2):287-307 [12213659] Mol Cell Biol. 2003 Feb;23(4):1368-78 [12556496] RNA. 2003 Aug;9(8):993-1006 [12869710] Mol Cell. 2003 Aug;12(2):525-32 [14536091] Methods Enzymol. 2003;370:138-55 [14712640] Science. 2004 Feb 13;303(5660):1014-6 [14963331] Genetics. 2004 Mar;166(3):1215-27 [15082542] Mol Cell Biol. 2004 May;24(9):3983-91 [15082791] Nat Struct Mol Biol. 2004 May;11(5):394-403 [15114340] Cell. 2004 Jul 9;118(1):31-44 [15242642] Nucleic Acids Res. 2004;32(18):5379-91 [15477388] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] J Biol Chem. 1985 Oct 25;260(24):13190-8 [2414275] Cell. 1987 Sep 11;50(6):909-15 [3304659] Mol Gen Genet. 1989 Jan;215(2):266-75 [2496296] Mol Cell Biol. 1990 Mar;10(3):1270-5 [2406567] Curr Genet. 1992 Jul;22(1):9-11 [1611672] Mol Cell Biol. 1992 Sep;12(9):4142-52 [1508210] Mol Cell Biol. 1994 Jan;14(1):226-37 [8264591] Genetics. 1994 Aug;137(4):945-56 [7982575] Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 [7984417] J Biol Chem. 1996 Mar 15;271(11):5993-9 [8626382] J Biol Chem. 1996 Mar 22;271(12):6866-73 [8636112] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11552-7 [8876173] Genes Dev. 1998 Feb 1;12(3):357-69 [9450930] J Bacteriol. 1998 May;180(10):2590-8 [9573141] Mol Cell Biol. 1998 Oct;18(10):5771-9 [9742094] J Biol Chem. 2004 Nov 19;279(47):49455-9 [15356001] Mol Cell. 2004 Dec 22;16(6):955-65 [15610738] Mol Cell. 2005 Jan 7;17(1):103-12 [15629721] Cell. 2005 Jan 28;120(2):183-93 [15680325] Mol Cell Biol. 2005 Apr;25(7):2650-9 [15767671] Mol Cell. 2005 Mar 18;17(6):831-40 [15780939] J Biol Chem. 2000 May 5;275(18):13780-8 [10788499] Mol Cell Biol. 2000 Aug;20(16):5960-73 [10913179] Science. 2000 Jul 28;289(5479):619-25 [10915625] J Biol Chem. 2000 Sep 22;275(38):29623-7 [10858443] Mol Cell Biol. 2000 Oct;20(20):7427-37 [11003640] J Biol Chem. 2001 Jan 12;276(2):1523-30 [11035032] PLoS Comput Biol. 2005 Sep;1(4):e39 [16172632] Science. 2001 Jun 8;292(5523):1876-82 [11313499] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. AN - 67899151; 16539655 AB - Telomeres are specialized structures at the ends of chromosomes that consist of tandem repeats of the DNA sequence TTAGGG and several proteins that protect the DNA and regulate the plasticity of the telomeres. The telomere-associated protein TRF2 (telomeric repeat binding factor 2) is critical for the control of telomere structure and function; TRF2 dysfunction results in the exposure of the telomere ends and activation of ATM (ataxia telangiectasin mutated)-mediated DNA damage response. Recent findings suggest that telomere attrition can cause senescence or apoptosis of mitotic cells, but the function of telomeres in differentiated neurons is unknown. Here, we examined the impact of telomere dysfunction via TRF2 inhibition in neurons (primary embryonic hippocampal neurons) and mitotic neural cells (astrocytes and neuroblastoma cells). We demonstrate that telomere dysfunction induced by adenovirus-mediated expression of dominant-negative TRF2 (DN-TRF2) triggers a DNA damage response involving the formation of nuclear foci containing phosphorylated histone H2AX and activated ATM in each cell type. In mitotic neural cells DN-TRF2 induced activation of both p53 and p21 and senescence (as indicated by an up-regulation of beta-galactosidase). In contrast, in neurons DN-TRF2 increased p21, but neither p53 nor beta-galactosidase was induced. In addition, TRF2 inhibition enhanced the morphological, molecular and biophysical differentiation of hippocampal neurons. These findings demonstrate divergent molecular and physiological responses to telomere dysfunction in mitotic neural cells and neurons, indicate a role for TRF2 in regulating neuronal differentiation, and suggest a potential therapeutic application of inhibition of TRF2 function in the treatment of neural tumors. JF - Journal of neurochemistry AU - Zhang, Peisu AU - Furukawa, Katsutoshi AU - Opresko, Patricia L AU - Xu, Xiangru AU - Bohr, Vilhelm A AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 567 EP - 581 VL - 97 IS - 2 SN - 0022-3042, 0022-3042 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Histones KW - Ion Channels KW - Nuclear Proteins KW - RNA, Messenger KW - TATA Box Binding Protein-Like Proteins KW - TERF2 protein, human KW - Telomeric Repeat Binding Protein 2 KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Checkpoint Kinase 2 KW - EC 2.7.1.11 KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - CHEK2 protein, human KW - Protein-Serine-Threonine Kinases KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Electric Stimulation -- methods KW - Membrane Potentials -- radiation effects KW - Protein-Serine-Threonine Kinases -- metabolism KW - Humans KW - Ion Channels -- physiology KW - Neuroblastoma KW - RNA, Messenger -- biosynthesis KW - Membrane Potentials -- genetics KW - Tumor Suppressor Proteins -- metabolism KW - Protein Structure, Tertiary -- physiology KW - Gene Expression -- physiology KW - Embryo, Mammalian KW - Green Fluorescent Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Cloning, Molecular -- methods KW - Cell Line, Tumor KW - Dose-Response Relationship, Radiation KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Transfection -- methods KW - Bromodeoxyuridine -- pharmacokinetics KW - Histones -- metabolism KW - Hippocampus -- cytology KW - Astrocytes -- metabolism KW - DNA Damage -- physiology KW - Cell Differentiation -- physiology KW - TATA Box Binding Protein-Like Proteins -- metabolism KW - Cell Aging -- physiology KW - Neurons -- physiology KW - Nuclear Proteins -- metabolism KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67899151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=TRF2+dysfunction+elicits+DNA+damage+responses+associated+with+senescence+in+proliferating+neural+cells+and+differentiation+of+neurons.&rft.au=Zhang%2C+Peisu%3BFurukawa%2C+Katsutoshi%3BOpresko%2C+Patricia+L%3BXu%2C+Xiangru%3BBohr%2C+Vilhelm+A%3BMattson%2C+Mark+P&rft.aulast=Zhang&rft.aufirst=Peisu&rft.date=2006-04-01&rft.volume=97&rft.issue=2&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-08 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protection against prenatal alcohol-induced damage. AN - 67882175; 16605309 JF - PLoS medicine AU - Spong, Catherine Y AD - Pregnancy and Perinatology Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. spongc@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1 VL - 3 IS - 4 KW - Central Nervous System Depressants KW - 0 KW - Vitamin B Complex KW - 12001-76-2 KW - Niacinamide KW - 25X51I8RD4 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Central Nervous System Depressants -- toxicity KW - Humans KW - Adult KW - Ethanol -- toxicity KW - Disease Models, Animal KW - Mice KW - Female KW - Pregnancy KW - Vitamin B Complex -- pharmacology KW - Niacinamide -- pharmacology KW - Fetal Alcohol Spectrum Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67882175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=Protection+against+prenatal+alcohol-induced+damage.&rft.au=Spong%2C+Catherine+Y&rft.aulast=Spong&rft.aufirst=Catherine&rft.date=2006-04-01&rft.volume=3&rft.issue=4&rft.spage=e196&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-04-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2001 May;297(2):774-9 [11303069] JAMA. 2003 Dec 10;290(22):2996-9 [14665662] Brain Res Dev Brain Res. 2004 Jun 21;150(2):117-24 [15158075] J Mol Neurosci. 2004;24(2):189-99 [15456932] PLoS Med. 2006 Apr;3(4):e101 [16478293] Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):1028-34 [16157106] Teratology. 1997 Nov;56(5):317-26 [9451756] Obstet Gynecol. 2005 Nov;106(5 Pt 1):1059-64 [16260526] Alcohol Clin Exp Res. 2006 Jan;30(1):127-34 [16433740] Comment On: PLoS Med. 2006 Apr;3(4):e101 [16478293] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Calorie restriction mimetics: an emerging research field. AN - 67876245; 16626389 AB - When considering all possible aging interventions evaluated to date, it is clear that calorie restriction (CR) remains the most robust. Studies in numerous species have demonstrated that reduction of calories 30-50% below ad libitum levels of a nutritious diet can increase lifespan, reduce the incidence and delay the onset of age-related diseases, improve stress resistance, and decelerate functional decline. A current major focus of this research area is whether this nutritional intervention is relevant to human aging. Evidence emerging from studies in rhesus monkeys suggests that their response to CR parallels that observed in rodents. To assess CR effects in humans, clinical trials have been initiated. However, even if results from these studies could eventually substantiate CR as an effective pro-longevity strategy for humans, the utility of this intervention would be hampered because of the degree and length of restriction required. As an alternative strategy, new research has focused on the development of 'CR mimetics'. The objective of this strategy is to identify compounds that mimic CR effects by targeting metabolic and stress response pathways affected by CR, but without actually restricting caloric intake. For example, drugs that inhibit glycolysis (2-deoxyglucose), enhance insulin action (metformin), or affect stress signaling pathways (resveratrol), are being assessed as CR mimetics (CRM). Promising results have emerged from initial studies regarding physiological responses which resemble those observed in CR (e.g. reduced body temperature and plasma insulin) as well as protection against neurotoxicity (e.g. enhanced dopamine action and up-regulated neurotrophic factors). Ultimately, lifespan analyses in addition to expanded toxicity studies must be accomplished to fully assess the potential of any CRM. Nonetheless, this strategy clearly offers a very promising and expanding research endeavor. JF - Aging cell AU - Ingram, Donald K AU - Zhu, Min AU - Mamczarz, Jacek AU - Zou, Sige AU - Lane, Mark A AU - Roth, George S AU - deCabo, Rafael AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. ingramd@grc.nia.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 97 EP - 108 VL - 5 IS - 2 SN - 1474-9718, 1474-9718 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Sirtuins KW - EC 3.5.1.- KW - Index Medicus KW - Animals KW - Sirtuins -- metabolism KW - Humans KW - Insulin-Like Growth Factor I -- metabolism KW - Glycolysis KW - Biomedical Research -- trends KW - Biomimetics -- trends KW - Caloric Restriction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67876245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+cell&rft.atitle=Calorie+restriction+mimetics%3A+an+emerging+research+field.&rft.au=Ingram%2C+Donald+K%3BZhu%2C+Min%3BMamczarz%2C+Jacek%3BZou%2C+Sige%3BLane%2C+Mark+A%3BRoth%2C+George+S%3BdeCabo%2C+Rafael&rft.aulast=Ingram&rft.aufirst=Donald&rft.date=2006-04-01&rft.volume=5&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Aging+cell&rft.issn=14749718&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-31 N1 - Date created - 2006-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemotherapeutic approaches for targeting cell death pathways. AN - 67866046; 16614230 AB - For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death in mammalian tissues. It also has been increasingly noted that conventional chemotherapeutic agents not only elicit apoptosis but other forms of nonapoptotic death such as necrosis, autophagy, mitotic catastrophe, and senescence. This review presents background on the signaling pathways involved in the different cell death outcomes. A re-examination of what we know about chemotherapy-induced death is vitally important in light of new understanding of nonapoptotic cell death signaling pathways. If we can precisely activate or inhibit molecules that mediate the diversity of cell death outcomes, perhaps we can succeed in more effective and less toxic chemotherapeutic regimens. JF - The oncologist AU - Ricci, M Stacey AU - Zong, Wei-Xing AD - National Cancer Institute and Food and Drug Administration Interagency Oncology Task Force, Bethesda, Maryland, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 342 EP - 357 VL - 11 IS - 4 SN - 1083-7159, 1083-7159 KW - Antineoplastic Agents KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Receptors, Tumor Necrosis Factor KW - Index Medicus KW - Autophagy -- drug effects KW - Animals KW - Genes, Neoplasm -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Intracellular Signaling Peptides and Proteins -- drug effects KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Cell Aging -- drug effects KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Necrosis -- chemically induced KW - Apoptosis -- drug effects KW - Mitosis -- drug effects KW - Receptors, Tumor Necrosis Factor -- metabolism KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Signal Transduction -- drug effects KW - Cell Death -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67866046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Chemotherapeutic+approaches+for+targeting+cell+death+pathways.&rft.au=Ricci%2C+M+Stacey%3BZong%2C+Wei-Xing&rft.aulast=Ricci&rft.aufirst=M&rft.date=2006-04-01&rft.volume=11&rft.issue=4&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2004 Nov 5;306(5698):990-5 [15528435] J Biol Chem. 2004 Nov 12;279(46):48168-76 [15337764] Nat Cell Biol. 2004 Dec;6(12):1221-8 [15558033] Biochemistry (Mosc). 2002 Apr;67(4):387-408 [11996653] Cell. 2002 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AN - 67863394; 16608830 AB - Radon is a well-established cause of lung cancer in miners. Residents of homes with high levels of radon are potentially also at risk. Although most individual studies of indoor radon have failed to demonstrate significant risks, results have generally been consistent with estimates from studies of miners. We studied 1474 incident lung cancer cases aged 40-79 yr in Connecticut, Utah, and southern Idaho. Population controls (n = 1811) were identified by random telephone screening and from lists of Medicare recipients, and were selected to be similar to cases on age, gender, and smoking 10 yr before diagnosis/interview using randomized recruitment. Complete residential histories and information on known lung cancer risk factors were obtained by in-person and telephone interviews. Radon was measured on multiple levels of past and current homes using 12-mo alpha-track etch detectors. Missing data were imputed using mean radon concentrations for informative subgroups of controls. Average radon exposures were lower than anticipated, with median values of 23 Bq/m3 in Connecticut and 45 Bq/m3 in Utah/southern Idaho. Overall, there was little association between time-weighted average radon exposures 5 to 25 yr prior to diagnosis/interview and lung cancer risk. The excess relative risk (ERR) associated with a 100-Bq/m3 increase in radon level was 0.002 (95% CI -0.21, 0.21) in the overall population, 0.134 (95% CI -0.23, 0.50) in Connecticut, and -0.112 (95% CI -0.34, 0.11) in Utah/Idaho. ERRs were higher for some subgroups less prone to misclassification, but there was no group with a statistically significant linear increase in risk. While results were consistent with the estimates from studies of miners, this study provides no evidence of an increased risk for lung cancer at the exposure levels observed. JF - Journal of toxicology and environmental health. Part A AU - Sandler, Dale P AU - Weinberg, Clarice R AU - Shore, David L AU - Archer, Victor E AU - Stone, Mary Bishop AU - Lyon, Joseph L AU - Rothney-Kozlak, Lynne AU - Shepherd, Marsha AU - Stolwijk, Jan A J AD - Epidemiology Branch, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. sandler@niehs.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 633 EP - 654 VL - 69 IS - 7 SN - 1528-7394, 1528-7394 KW - Air Pollutants, Radioactive KW - 0 KW - Carcinogens, Environmental KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Housing KW - Humans KW - Utah -- epidemiology KW - Medicare KW - Aged KW - Dose-Response Relationship, Radiation KW - Risk Assessment KW - Adult KW - Connecticut -- epidemiology KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - Female KW - Male KW - Air Pollution, Indoor -- adverse effects KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Neoplasms, Radiation-Induced -- etiology KW - Carcinogens, Environmental -- adverse effects KW - Neoplasms, Radiation-Induced -- epidemiology KW - Air Pollutants, Radioactive -- adverse effects KW - Radon -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67863394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Indoor+radon+and+lung+cancer+risk+in+connecticut+and+utah.&rft.au=Sandler%2C+Dale+P%3BWeinberg%2C+Clarice+R%3BShore%2C+David+L%3BArcher%2C+Victor+E%3BStone%2C+Mary+Bishop%3BLyon%2C+Joseph+L%3BRothney-Kozlak%2C+Lynne%3BShepherd%2C+Marsha%3BStolwijk%2C+Jan+A+J&rft.aulast=Sandler&rft.aufirst=Dale&rft.date=2006-04-01&rft.volume=69&rft.issue=7&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. AN - 67860925; 16618406 AB - Although the natural history and pathologic characteristics of human hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC remains poorly understood. Here, we define the role for Ras and Janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathways in human HCC. Promoter and genomic status of Ras and Jak/Stat inhibitors were assessed in 80 HCCs by methylation-specific polymerase chain reaction and microsatellite analysis. Activation of Ras and Jak/Stat signaling pathways was determined by DNA sequencing, Western blot, and immunoprecipitation analysis. Suppression of Ras and Jak/Stat pathways in HCC cell lines was evaluated by viability and apoptosis assays. Activation of Ras and Jak/Stat pathways was enhanced in all HCCs when compared with nonneoplastic surrounding and normal livers coincidently with the suppression of at least 1 Ras (RASSF1A and/or NORE1A) and 2 Jak/Stat inhibitors (cytokine-inducible SH2-protein [CIS]; suppressor of cytokine signaling [SOCS]1, 2, 3; and SH2-containing phosphatases [SHP1]). HCC associated with cirrhosis showed significantly higher frequency of RASSF1A, CIS, and SOCS1 promoter methylation than HCC without cirrhosis (P < .002, P < .02, and P < .02, respectively). Furthermore, aberrant methylation of NORE1A and SOCS3 promoters was observed only in a subclass of HCC with poor survival, suggesting that inactivation of these 2 genes might be involved in HCC progression. Combined treatment of HCC cell lines with Ras and Jak/Stat inhibitors as well as with the demethylating agent zebularine induced a strong apoptotic response. These data demonstrate the ubiquitous activation of Ras and Jak/Stat pathways in HCC and suggest the potential use of Ras and Jak/Stat inhibitors and demethylating agents as therapeutic modality for human liver cancer. JF - Gastroenterology AU - Calvisi, Diego F AU - Ladu, Sara AU - Gorden, Alexis AU - Farina, Miriam AU - Conner, Elizabeth A AU - Lee, Ju-Seog AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4262, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1117 EP - 1128 VL - 130 IS - 4 SN - 0016-5085, 0016-5085 KW - Immediate-Early Proteins KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - RASSF1 protein, human KW - RASSF5 protein, human KW - STAT Transcription Factors KW - Suppressor of Cytokine Signaling Proteins KW - Tumor Suppressor Proteins KW - cytokine inducible SH2-containing protein KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - PTPN6 protein, human KW - EC 3.1.3.48 KW - Protein Tyrosine Phosphatase, Non-Receptor Type 6 KW - Protein Tyrosine Phosphatases KW - Monomeric GTP-Binding Proteins KW - EC 3.6.5.2 KW - ras Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Protein Tyrosine Phosphatases -- metabolism KW - Enzyme Activation KW - Immediate-Early Proteins -- metabolism KW - Humans KW - Monomeric GTP-Binding Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Tissue Distribution KW - Suppressor of Cytokine Signaling Proteins -- genetics KW - Monomeric GTP-Binding Proteins -- genetics KW - Suppressor of Cytokine Signaling Proteins -- metabolism KW - Promoter Regions, Genetic KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Loss of Heterozygosity KW - DNA Methylation KW - Down-Regulation KW - Tumor Suppressor Proteins -- metabolism KW - Adult KW - Middle Aged KW - Signal Transduction KW - Female KW - Male KW - Cell Division KW - STAT Transcription Factors -- metabolism KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - ras Proteins -- metabolism KW - Liver Neoplasms -- genetics KW - JNK Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67860925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Ubiquitous+activation+of+Ras+and+Jak%2FStat+pathways+in+human+HCC.&rft.au=Calvisi%2C+Diego+F%3BLadu%2C+Sara%3BGorden%2C+Alexis%3BFarina%2C+Miriam%3BConner%2C+Elizabeth+A%3BLee%2C+Ju-Seog%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Calvisi&rft.aufirst=Diego&rft.date=2006-04-01&rft.volume=130&rft.issue=4&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-15 N1 - Date created - 2006-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of a genetic glissando: structural biology of indel mutations. AN - 67856788; 16545956 AB - Insertions and deletions of bases in DNA (collectively termed "indels") are both common and biologically relevant, being associated with different human pathologies including cancer and diseases associated with expansions of repeats. Four decades of research have resulted in several hypotheses regarding how indels are generated during DNA synthesis and how they subsequently undergo or escape correction. Recent structural studies of DNA polymerases bound to mutagenic substrates have increased our understanding of how DNA polymerases cope with abnormal substrates. These structures provide insight into the molecular mechanisms underlying indel generation. JF - Trends in biochemical sciences AU - Garcia-Diaz, Miguel AU - Kunkel, Thomas A AD - Laboratory of Structural Biology and Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 206 EP - 214 VL - 31 IS - 4 SN - 0968-0004, 0968-0004 KW - DNA KW - 9007-49-2 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - DNA Damage KW - Models, Genetic KW - Humans KW - Nucleic Acid Conformation KW - Mutation KW - DNA -- biosynthesis KW - Mutagenesis, Insertional KW - DNA-Directed DNA Polymerase -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67856788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+biochemical+sciences&rft.atitle=Mechanism+of+a+genetic+glissando%3A+structural+biology+of+indel+mutations.&rft.au=Garcia-Diaz%2C+Miguel%3BKunkel%2C+Thomas+A&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2006-04-01&rft.volume=31&rft.issue=4&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Trends+in+biochemical+sciences&rft.issn=09680004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction? AN - 67852712; 16611095 AB - Galanin is a neuropeptide synthesized in many neuronal types including brainstem norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons of the dorsal raphe nucleus. Galanin inhibits the firing of rodent norepinephrine, serotonin and dopamine neurons and reduces release of these neurotransmitters in forebrain target regions. The distribution of galanin and its receptors and its actions on monoamine signaling has fostered interest in this neuropeptide in the field of behavioral pharmacology and the potential role of galanin in the pathophysiology of neurological diseases such as Alzheimer's disease, epilepsy, stroke, and in psychiatric disorders such as anxiety, depression, and drug addiction, particularly withdrawal. In rodent models, expression of galanin in brain is altered by various stressors, while administration of galanin can modulate anxiety-like responses to stress. Emerging evidence further supports a role for galanin in the mediation of depression-related behaviors in rodents. Recently, galanin agonists have been shown to decrease behavioral signs of opiate withdrawal, which are thought to result from hyperactivation of brain stress pathways. Studies using genetically modified mice suggest that galanin normally plays a protective role against opiate reinforcement and withdrawal. The present article reviews current evidence on a potential role for galanin in modulating stress-related neural pathways and behaviors, and speculates on the therapeutic potential of targeting this galanin system for emotional disorders and opiate addiction. JF - CNS & neurological disorders drug targets AU - Holmes, A AU - Picciotto, M R AD - Laboratory for Integrative Neuroscience, Section on Behavioral Science and Genetics, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA. holmesan@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 225 EP - 232 VL - 5 IS - 2 SN - 1871-5273, 1871-5273 KW - Biogenic Amines KW - 0 KW - Galanin KW - 88813-36-9 KW - Index Medicus KW - Biogenic Amines -- metabolism KW - Animals KW - Stress, Psychological -- metabolism KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- metabolism KW - Stress, Psychological -- physiopathology KW - Humans KW - Substance Withdrawal Syndrome -- drug therapy KW - Stress, Psychological -- drug therapy KW - Substance-Related Disorders -- physiopathology KW - Galanin -- metabolism KW - Brain -- drug effects KW - Anxiety Disorders -- metabolism KW - Brain -- metabolism KW - Anxiety Disorders -- physiopathology KW - Brain -- physiopathology KW - Anxiety Disorders -- drug therapy KW - Galanin -- agonists KW - Depressive Disorder -- physiopathology KW - Substance-Related Disorders -- drug therapy KW - Depressive Disorder -- drug therapy KW - Substance-Related Disorders -- metabolism KW - Depressive Disorder -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67852712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+%26+neurological+disorders+drug+targets&rft.atitle=Galanin%3A+a+novel+therapeutic+target+for+depression%2C+anxiety+disorders+and+drug+addiction%3F&rft.au=Holmes%2C+A%3BPicciotto%2C+M+R&rft.aulast=Holmes&rft.aufirst=A&rft.date=2006-04-01&rft.volume=5&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=CNS+%26+neurological+disorders+drug+targets&rft.issn=18715273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. AN - 67849029; 16602711 AB - Prodynorphin-derived peptides elicit various pathological effects including neurological dysfunction and cell death. These actions are reduced by N-methyl-d-aspartate receptor (NMDAR) but not opioid receptor antagonists suggesting NMDAR-mediation. Here, we show that a conserved epitope (KVNSEEEEEDA) of the NR1 subunit of the NMDAR binds dynorphin peptides (DYNp) noncovalently. Synthetic peptides containing this epitope form stable complexes with DYNp and prevent the potentiation of NMDAR-gated currents produced by DYNp. They attenuate DYNp-evoked cell death in spinal cord and prevent, as well as reverse, DYNp-induced paralysis and allodynia. The data reveal a novel mechanism whereby prodynorphin-derived peptides facilitate NMDAR function and produce neurotoxicity. Furthermore, they suggest that synthetic peptides that bind DYNp, thus preventing their interaction with NMDAR, may be novel therapeutic agents for the treatment of spinal cord injury. JF - Journal of proteome research AU - Woods, Amina S AU - Kaminski, Rafal AU - Oz, Murat AU - Wang, Yun AU - Hauser, Kurt AU - Goody, Robin AU - Wang, Hay-Yan J AU - Jackson, Shelley N AU - Zeitz, Peter AU - Zeitz, Karla P AU - Zolkowska, Dorota AU - Schepers, Raf AU - Nold, Michael AU - Danielson, Jens AU - Gräslund, Astrid AU - Vukojevic, Vladana AU - Bakalkin, Georgy AU - Basbaum, Allan AU - Shippenberg, Toni AD - NIH/NIDA IRP, Baltimore, Maryland 21224, USA. awoods@intra.nida.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1017 EP - 1023 VL - 5 IS - 4 SN - 1535-3893, 1535-3893 KW - Neuroprotective Agents KW - 0 KW - Peptides KW - RNA, Messenger KW - Receptors, N-Methyl-D-Aspartate KW - Dynorphins KW - 74913-18-1 KW - Index Medicus KW - Animals KW - Rats KW - Behavior, Animal -- drug effects KW - Apoptosis -- drug effects KW - Molecular Sequence Data KW - Xenopus KW - Spinal Cord -- pathology KW - Ganglia, Spinal -- drug effects KW - Time Factors KW - Male KW - Mice, Inbred ICR KW - Spinal Cord -- metabolism KW - Models, Molecular KW - Amino Acid Sequence KW - Mice KW - Electrophysiology KW - Microinjections KW - Ganglia, Spinal -- embryology KW - Ganglia, Spinal -- cytology KW - Rats, Sprague-Dawley KW - Conserved Sequence KW - Oocytes -- metabolism KW - Paralysis -- chemically induced KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Nuclear Magnetic Resonance, Biomolecular KW - Spinal Cord -- drug effects KW - Immunohistochemistry KW - Female KW - Neuroprotective Agents -- chemistry KW - Neurotoxicity Syndromes -- prevention & control KW - Neuroprotective Agents -- metabolism KW - Peptides -- metabolism KW - Peptides -- chemistry KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Peptides -- pharmacology KW - Dynorphins -- metabolism KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67849029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteome+research&rft.atitle=Decoy+peptides+that+bind+dynorphin+noncovalently+prevent+NMDA+receptor-mediated+neurotoxicity.&rft.au=Woods%2C+Amina+S%3BKaminski%2C+Rafal%3BOz%2C+Murat%3BWang%2C+Yun%3BHauser%2C+Kurt%3BGoody%2C+Robin%3BWang%2C+Hay-Yan+J%3BJackson%2C+Shelley+N%3BZeitz%2C+Peter%3BZeitz%2C+Karla+P%3BZolkowska%2C+Dorota%3BSchepers%2C+Raf%3BNold%2C+Michael%3BDanielson%2C+Jens%3BGr%C3%A4slund%2C+Astrid%3BVukojevic%2C+Vladana%3BBakalkin%2C+Georgy%3BBasbaum%2C+Allan%3BShippenberg%2C+Toni&rft.aulast=Woods&rft.aufirst=Amina&rft.date=2006-04-01&rft.volume=5&rft.issue=4&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteome+research&rft.issn=15353893&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-04-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Physiol Behav. 1999 Nov;67(5):711-6 [10604842] J Proteome Res. 2006 Jan;5(1):122-6 [16396502] Pain. 2000 May;86(1-2):185-94 [10779675] Pain. 2000 Sep;87(3):235-9 [10963903] J Am Soc Mass Spectrom. 2001 Jan;12(1):88-96 [11142364] Exp Neurol. 2001 Mar;168(1):78-87 [11170722] J Pharmacol Exp Ther. 2001 Oct;299(1):6-11 [11561057] J Am Soc Mass Spectrom. 2002 Feb;13(2):166-9 [11838019] Life Sci. 2003 Jun 27;73(6):783-800 [12801599] J Proteome Res. 2004 May-Jun;3(3):478-84 [15253429] J Pharmacol Exp Ther. 1985 Jan;232(1):27-32 [2856940] Ann Neurol. 1985 Apr;17(4):386-90 [2860844] Brain Res. 1987 Nov 10;425(2):225-33 [2892572] Brain Res. 1987 Dec 1;435(1-2):1-6 [2892573] Brain Res. 1988 Mar 8;443(1-2):329-32 [2896056] J Pharmacol Exp Ther. 1988 Sep;246(3):1167-74 [2901487] Brain Res. 1989 Sep 11;497(1):155-62 [2571391] Brain Res. 1990 Jan 15;507(1):1-5 [1967971] Exp Brain Res. 1993;96(2):291-303 [7505750] Pain. 1996 Dec;68(2-3):275-81 [9121815] J Neurosci. 1997 Jun 15;17(12):4580-90 [9169519] J Neurophysiol. 1997 Aug;78(2):582-90 [9307096] J Pharmacol Exp Ther. 1997 Nov;283(2):604-10 [9353375] J Neurotrauma. 1998 Jul;15(7):485-94 [9674552] Front Biosci. 2005 Jan 1;10:216-35 [15574363] J Mol Neurosci. 2005;26(2-3):125-32 [16012186] FEBS J. 2005 Aug;272(15):3938-49 [16045764] J Proteome Res. 2005 Jul-Aug;4(4):1397-402 [16083292] Exp Neurol. 1999 Dec;160(2):361-75 [10619553] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. AN - 67839769; 16532004 AB - The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes. These phenotypes may result from activation of different oncogenic pathways during tumorigenesis and/or from a different cell of origin. Here we address whether the transcriptional characteristics of HCC can provide insight into the cellular origin of the tumor. We integrated gene expression data from rat fetal hepatoblasts and adult hepatocytes with HCC from human and mouse models. Individuals with HCC who shared a gene expression pattern with fetal hepatoblasts had a poor prognosis. The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells. Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development. JF - Nature medicine AU - Lee, Ju-Seog AU - Heo, Jeonghoon AU - Libbrecht, Louis AU - Chu, In-Sun AU - Kaposi-Novak, Pal AU - Calvisi, Diego F AU - Mikaelyan, Arsen AU - Roberts, Lewis R AU - Demetris, Anthony J AU - Sun, Zongtang AU - Nevens, Frederik AU - Roskams, Tania AU - Thorgeirsson, Snorri S AD - Lab of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 4146, Bethesda, Maryland 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 410 EP - 416 VL - 12 IS - 4 SN - 1078-8956, 1078-8956 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Animals KW - Apoptosis KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Aged KW - Mice KW - DNA, Neoplasm -- analysis KW - Cell Proliferation KW - Models, Biological KW - Rats KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Genes, Neoplasm KW - European Continental Ancestry Group KW - Cohort Studies KW - DNA, Neoplasm -- genetics KW - Immunohistochemistry KW - China -- ethnology KW - Cluster Analysis KW - Male KW - Female KW - Survival Analysis KW - Liver Neoplasms -- pathology KW - Stem Cells -- cytology KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Carcinoma, Hepatocellular -- classification KW - Stem Cells -- physiology KW - Hepatocytes -- physiology KW - Hepatocytes -- cytology KW - Liver Neoplasms -- diagnosis KW - Liver Neoplasms -- classification KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67839769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+medicine&rft.atitle=A+novel+prognostic+subtype+of+human+hepatocellular+carcinoma+derived+from+hepatic+progenitor+cells.&rft.au=Lee%2C+Ju-Seog%3BHeo%2C+Jeonghoon%3BLibbrecht%2C+Louis%3BChu%2C+In-Sun%3BKaposi-Novak%2C+Pal%3BCalvisi%2C+Diego+F%3BMikaelyan%2C+Arsen%3BRoberts%2C+Lewis+R%3BDemetris%2C+Anthony+J%3BSun%2C+Zongtang%3BNevens%2C+Frederik%3BRoskams%2C+Tania%3BThorgeirsson%2C+Snorri+S&rft.aulast=Lee&rft.aufirst=Ju-Seog&rft.date=2006-04-01&rft.volume=12&rft.issue=4&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Nature+medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-05 N1 - Date created - 2006-04-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GPL1528; GEO; GPL1529; GSE1898; GSE1897; GSE4024 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical antipsychotic-induced akathisia with depression: therapeutic role of mirtazapine. AN - 67832035; 16569791 AB - To investigate the efficacy of mirtazapine in treating akathisia caused by risperidone and olanzapine, as well as its use in alleviating comorbid depressive disorder. Five patients with diagnoses varying from schizophrenia, delusional disorder, and bipolar disorder developed akathisia while on treatment with olanzapine and risperidone. The likelihood that risperidone and olanzapine had induced akathisia in all patients was rated probable according to the Naranjo probability scale. Four of these patients were also found to be depressed. The akathisia was successfully treated with mirtazapine, and 3 of the 4 depressed patients improved with mirtazapine treatment. Use of mirtazapine did not result in any adverse effect. Mirtazapine is a potent antagonist of central alpha(2) auto- and hetero-adrenergic receptors, as well as an antagonist of 5-HT(2A/2C), 5-HT(3), and histaminergic H(1) postsynaptic receptors. The efficacy of mirtazapine in treatment of akathisia may result from its antagonist property at the H(1) receptors and its dopaminergic activity in frontal cortex. The use of mirtazapine offers advantages over other anti-akathisia drugs in its better adverse effect profile, as well as its ability to treat coexisting depression. Mirtazapine is efficacious in treating atypical antipsychotic-induced akathisia. It may be a good option, particularly in patients with coexisting depression. JF - The Annals of pharmacotherapy AU - Ranjan, Sanjeev AU - Chandra, Prabha S AU - Chaturvedi, Santosh K AU - Prabhu, Santosh C AU - Gupta, Arun AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. esarsingh@yahoo.co.in Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 771 EP - 774 VL - 40 IS - 4 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Serotonin Antagonists KW - Benzodiazepines KW - 12794-10-4 KW - Mianserin KW - 250PJI13LM KW - mirtazapine KW - A051Q2099Q KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Benzodiazepines -- therapeutic use KW - Benzodiazepines -- adverse effects KW - Humans KW - Adult KW - Treatment Outcome KW - Male KW - Female KW - Serotonin Antagonists -- therapeutic use KW - Akathisia, Drug-Induced -- drug therapy KW - Mianserin -- therapeutic use KW - Serotonin Antagonists -- administration & dosage KW - Antipsychotic Agents -- therapeutic use KW - Mianserin -- administration & dosage KW - Risperidone -- adverse effects KW - Akathisia, Drug-Induced -- etiology KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Mianserin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67832035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Atypical+antipsychotic-induced+akathisia+with+depression%3A+therapeutic+role+of+mirtazapine.&rft.au=Ranjan%2C+Sanjeev%3BChandra%2C+Prabha+S%3BChaturvedi%2C+Santosh+K%3BPrabhu%2C+Santosh+C%3BGupta%2C+Arun&rft.aulast=Ranjan&rft.aufirst=Sanjeev&rft.date=2006-04-01&rft.volume=40&rft.issue=4&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stress responsivity and HPA axis activity in juveniles: results from a home-based CO2 inhalation study. AN - 67829863; 16585453 AB - A previous laboratory-based study found elevated cortisol levels in anxious children susceptible to CO(2)-induced panic, but the effects of parent diagnosis were not considered. The current home-based study tested the hypothesis that parental panic disorder and offspring response to CO(2) are associated with elevated cortisol levels in juvenile offspring. A total of 131 offspring (ages 9-19) of parents with panic disorder, major depression, and no mental disorder underwent CO(2) inhalation. Parent and child diagnoses were assessed. Salivary cortisol was assayed before and after CO(2) inhalation. Neither parents with panic disorder, parents with major depression, or offspring anxiety predicted offspring cortisol levels. Independent of parent and child diagnoses, anxiety response to CO(2) predicted elevated cortisol levels in offspring. As in adults, anxiety response to CO(2) in juveniles is associated with elevated cortisol levels, but elevated cortisol levels are not related to parent or child diagnoses. JF - The American journal of psychiatry AU - Terleph, Thomas A AU - Klein, Rachel G AU - Roberson-Nay, Roxann AU - Mannuzza, Salvatore AU - Moulton, John L AU - Woldehawariat, Girma AU - Guardino, Mary AU - Pine, Daniel S AD - NIMH, NIH, Bldg. 15-K, Rm. 110, MSC-2670, Bethesda, MD 20817-2670, USA. daniel.pine@nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 738 EP - 740 VL - 163 IS - 4 SN - 0002-953X, 0002-953X KW - Carbon Dioxide KW - 142M471B3J KW - Hydrocortisone KW - WI4X0X7BPJ KW - Abridged Index Medicus KW - Index Medicus KW - Probability KW - Depressive Disorder, Major -- diagnosis KW - Age Factors KW - Humans KW - Child KW - Depressive Disorder, Major -- genetics KW - Pituitary-Adrenal System -- physiology KW - Hypothalamo-Hypophyseal System -- physiology KW - Depressive Disorder, Major -- psychology KW - Adult KW - Administration, Inhalation KW - Adolescent KW - Female KW - Male KW - Panic Disorder -- chemically induced KW - Carbon Dioxide -- administration & dosage KW - Saliva -- chemistry KW - Child of Impaired Parents -- psychology KW - Panic Disorder -- genetics KW - Adolescent Behavior -- drug effects KW - Hydrocortisone -- analysis KW - Adolescent Behavior -- psychology KW - Child of Impaired Parents -- statistics & numerical data KW - Stress, Psychological -- diagnosis KW - Carbon Dioxide -- pharmacology KW - Stress, Psychological -- psychology KW - Panic Disorder -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67829863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Stress+responsivity+and+HPA+axis+activity+in+juveniles%3A+results+from+a+home-based+CO2+inhalation+study.&rft.au=Terleph%2C+Thomas+A%3BKlein%2C+Rachel+G%3BRoberson-Nay%2C+Roxann%3BMannuzza%2C+Salvatore%3BMoulton%2C+John+L%3BWoldehawariat%2C+Girma%3BGuardino%2C+Mary%3BPine%2C+Daniel+S&rft.aulast=Terleph&rft.aufirst=Thomas&rft.date=2006-04-01&rft.volume=163&rft.issue=4&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peripheral neuropathy induced by microtubule-stabilizing agents. AN - 67828781; 16575015 AB - Microtubule-stabilizing agents (MTSAs), including the taxanes and epothilones, are effective chemotherapeutic agents for the treatment of many cancers. Neuropathy is a major adverse effect of MTSA-based chemotherapy, with severe peripheral neuropathy (grade 3 or 4) occurring in as many as 30% of patients treated with a MTSA. MTSA-induced neuropathy usually resolves gradually after cessation of the treatment. The most reliable method to accurately assess MTSA-induced neuropathy is by clinical evaluation, although additional techniques are being developed and evaluated. Among MTSA-induced neuropathy, the most extensively studied is that induced by taxanes; such a neuropathy usually presents as sensory neuropathy and is more common with paclitaxel than docetaxel. The incidence of MTSA-induced neuropathy seems to depend on the MTSA dose per treatment cycle, the schedule of treatment, and the duration of the infusion. Although there have been several small clinical trials with neuroprotective agents, early recognition and supportive care are the best approaches for prevention and management of MTSA-induced neuropathy. In the future, research should focus on elucidating the mechanism of MTSA-induced neuropathy, developing reliable in vivo and in vitro preclinical models to study MTSA-induced neuropathy, developing a more reliable grading system for MTSA-induced neuropathy, developing more reliable methods for evaluating MTSA-induced neuropathy, and evaluating the efficacy of potential neuroprotective agents in clinical trials. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Lee, James J AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889-5015, USA. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 1633 EP - 1642 VL - 24 IS - 10 KW - Albumin-Bound Paclitaxel KW - 0 KW - Albumins KW - Antineoplastic Agents KW - Epothilones KW - Neuroprotective Agents KW - Tubulin Modulators KW - ixabepilone KW - K27005NP0A KW - Paclitaxel KW - P88XT4IS4D KW - epothilone B KW - UEC0H0URSE KW - Index Medicus KW - Animals KW - Pain Management KW - Paclitaxel -- adverse effects KW - Albumins -- adverse effects KW - Risk Factors KW - Humans KW - Epothilones -- adverse effects KW - Neuroprotective Agents -- therapeutic use KW - Tubulin Modulators -- adverse effects KW - Microtubules -- drug effects KW - Peripheral Nervous System Diseases -- therapy KW - Peripheral Nervous System Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- diagnosis KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Peripheral+neuropathy+induced+by+microtubule-stabilizing+agents.&rft.au=Lee%2C+James+J%3BSwain%2C+Sandra+M&rft.aulast=Lee&rft.aufirst=James&rft.date=2006-04-01&rft.volume=24&rft.issue=10&rft.spage=1633&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 expression. AN - 67825621; 16585173 AB - 2-Methoxyestradiol (2ME(2)), a metabolite of 17-beta-estradiol, inhibits angiogenesis and has additional antitumor activities. We have analyzed the tumor stage-specific effects of 2ME(2) in the C3(1)/Tag transgenic mouse model for breast cancer, which spontaneously develops estrogen receptor-negative mammary tumors following a predictable progression of lesion formation. When given either as a therapeutic agent in established tumors (late intervention study) or in mice with pre-invasive mammary lesions (early intervention study), tumor growth was reduced by 60% compared with untreated controls and was associated with an induction of apoptosis. In a prevention study, a significant reduction in mammary intraepithelial neoplasia (MIN) lesions was observed in animals beginning treatment at 6 weeks of age, before the appearance of histopathologic abnormalities. However, although 2ME(2) reduced the number of MIN lesions in the prevention study, a paradoxical increase in tumor multiplicity and growth rate was observed. This was associated with unusual cystic tumor formation, in which significant central necrosis was observed, surrounded by an outer region of proliferative tumor cell growth. The characteristics of the cystic tumor formation in mice treated with 2ME(2) at early ages are consistent with an impaired angiogenic response as observed in mice deficient for inhibitor of differentiation (Id-1). We further show that Id-1 expression is negatively regulated by 2ME(2), which may be an additional mechanism for the antiangiogenic effect of 2ME(2). Although 2ME(2) significantly reduced tumor growth at late stages, these results also suggest that altered tumor morphology and accelerated tumor growth may occur if 2ME(2) is administered in a prevention setting for prolonged periods. JF - Cancer research AU - Huh, Jung-Im AU - Calvo, Alfonso AU - Charles, Rhonda AU - Green, Jeffrey E AD - Laboratory of Cell Regulation and Carcinogenesis, Building 41, National Cancer Institute/NIH, Bethesda, MD 20892, USA. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 3495 EP - 3503 VL - 66 IS - 7 SN - 0008-5472, 0008-5472 KW - Idb1 protein, mouse KW - 0 KW - Inhibitor of Differentiation Protein 1 KW - Estradiol KW - 4TI98Z838E KW - 2-methoxyestradiol KW - 6I2QW73SR5 KW - Index Medicus KW - Endothelial Cells -- drug effects KW - Cell Growth Processes -- drug effects KW - Animals KW - Neoplasm Staging KW - Dose-Response Relationship, Drug KW - Apoptosis -- drug effects KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Down-Regulation -- drug effects KW - Female KW - Estradiol -- analogs & derivatives KW - Inhibitor of Differentiation Protein 1 -- genetics KW - Estradiol -- pharmacology KW - Mammary Neoplasms, Experimental -- drug therapy KW - Mammary Neoplasms, Experimental -- prevention & control KW - Mammary Neoplasms, Experimental -- metabolism KW - Inhibitor of Differentiation Protein 1 -- biosynthesis KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67825621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Distinct+tumor+stage-specific+inhibitory+effects+of+2-methoxyestradiol+in+a+breast+cancer+mouse+model+associated+with+Id-1+expression.&rft.au=Huh%2C+Jung-Im%3BCalvo%2C+Alfonso%3BCharles%2C+Rhonda%3BGreen%2C+Jeffrey+E&rft.aulast=Huh&rft.aufirst=Jung-Im&rft.date=2006-04-01&rft.volume=66&rft.issue=7&rft.spage=3495&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men. AN - 67825214; 16585475 AB - Although the behavioral effects of high-dose androgen administration may involve alterations in serotonergic activity, few studies have investigated the impact of androgen withdrawal on the central nervous system in humans. To examine the effects of pharmacologically induced hypogonadism on several cerebrospinal fluid (CSF) systems that could mediate the behavioral concomitants of hypogonadism. Double-blind assessment of the effects of the short-term induction of hypogonadism and subsequent replacement with testosterone and placebo in a crossover design. National Institutes of Health, Bethesda, Md. Twelve healthy male volunteers. We administered the gonadotropin-releasing hormone agonist leuprolide acetate (7.5 mg intramuscularly every 4 weeks) to the healthy male volunteers, creating a hypogonadal state, and then either replaced testosterone (200 mg intramuscularly) or administered a placebo every 2 weeks for 1 month. Mood and behavioral symptoms were monitored with daily self-ratings, and lumbar punctures were performed during both hypogonadal (placebo) and testosterone-replaced conditions for CSF levels of steroids and monoamine metabolites. The CSF testosterone, dihydrotestosterone, and androsterone levels were significantly lower during hypogonadism (P=.002, .04, and .046, respectively), but no significant changes were observed in CSF measures of 5-hydroxyindoleacetic acid, homovanillic acid, dehydroepiandrosterone, or pregnenolone. Decreased sexual interest was observed during the hypogonadal state compared with both baseline and testosterone replacement (P=.009) and correlated significantly with CSF measures of androsterone during both hypogonadism and testosterone replacement (r = -0.76 and -0.81, respectively; P<.01). Moreover, the change in severity of decreased sexual interest correlated significantly with the change in CSF androsterone levels between testosterone replacement and hypogonadism (r = -0.68; P<.05). The CSF 5-hydroxyindoleacetic acid and homovanillic acid levels did not correlate significantly with any behavioral or CSF measure. These data suggest that the neurosteroid androsterone contributes to the regulation of sexual function in men. JF - Archives of general psychiatry AU - Bloch, Miki AU - Rubinow, David R AU - Berlin, Kate AU - Kevala, Karl R AU - Kim, Hee-Yong AU - Schmidt, Peter J AD - Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 450 EP - 456 VL - 63 IS - 4 SN - 0003-990X, 0003-990X KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Testosterone KW - 3XMK78S47O KW - Estradiol KW - 4TI98Z838E KW - Androsterone KW - C24W7J5D5R KW - Leuprolide KW - EFY6W0M8TG KW - Abridged Index Medicus KW - Index Medicus KW - Dihydrotestosterone -- cerebrospinal fluid KW - Testosterone -- therapeutic use KW - Affect -- drug effects KW - Affect -- physiology KW - Double-Blind Method KW - Humans KW - Injections, Intramuscular KW - Testosterone -- cerebrospinal fluid KW - Radioimmunoassay KW - Estradiol -- blood KW - Testosterone -- blood KW - Adult KW - Cross-Over Studies KW - Middle Aged KW - Dihydrotestosterone -- blood KW - Adolescent KW - Male KW - Spinal Puncture KW - Hypogonadism -- cerebrospinal fluid KW - Androsterone -- blood KW - Androsterone -- cerebrospinal fluid KW - Leuprolide -- pharmacology KW - Sexual Behavior -- physiology KW - Androsterone -- metabolism KW - Leuprolide -- administration & dosage KW - Androsterone -- physiology KW - Sexual Behavior -- drug effects KW - Hypogonadism -- chemically induced KW - Hypogonadism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67825214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Monoamines+and+neurosteroids+in+sexual+function+during+induced+hypogonadism+in+healthy+men.&rft.au=Bloch%2C+Miki%3BRubinow%2C+David+R%3BBerlin%2C+Kate%3BKevala%2C+Karl+R%3BKim%2C+Hee-Yong%3BSchmidt%2C+Peter+J&rft.aulast=Bloch&rft.aufirst=Miki&rft.date=2006-04-01&rft.volume=63&rft.issue=4&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of chelation on blood pressure in lead-exposed children: a randomized study. AN - 67818816; 16581549 AB - Studies in children suggest a weak association between blood lead concentration and blood pressure. To understand this better, we tested the strength of the association in children with elevated blood lead concentrations and whether succimer chelation changed blood pressure as it did blood lead. In a randomized clinical trial of 780 children with blood lead concentrations of 20-44 microg/dL at 12-33 months of age, we compared the systolic and diastolic blood pressure in the succimer-treated group and placebo group for up to 5 years of follow-up. We also analyzed the relation of blood lead to blood pressure. Children in the succimer group had lower blood lead concentrations for 9-10 months during and after treatment, but their blood pressure did not differ from those in the placebo group during this period. During 1-5 years of follow-up, children in the succimer group had systolic blood pressure 1.09 (95% confidence interval, 0.27-1.90) mmHg higher than did untreated children in a model with repeated measurements, but the difference in diastolic blood pressure was not statistically significant. No association between blood lead and blood pressure was found. Overall, there is no association between blood lead and blood pressure in these children with moderately high lead exposure, nor does chelation with succimer change blood pressure. JF - Environmental health perspectives AU - Chen, Aimin AU - Rhoads, George G AU - Cai, Bo AU - Salganik, Mikhail AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 579 EP - 583 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - Chelating Agents KW - 0 KW - Placebos KW - Lead KW - 2P299V784P KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Child KW - Child, Preschool KW - Chelating Agents -- pharmacology KW - Lead -- toxicity KW - Blood Pressure -- drug effects KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67818816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+effect+of+chelation+on+blood+pressure+in+lead-exposed+children%3A+a+randomized+study.&rft.au=Chen%2C+Aimin%3BRhoads%2C+George+G%3BCai%2C+Bo%3BSalganik%2C+Mikhail%3BRogan%2C+Walter+J&rft.aulast=Chen&rft.aufirst=Aimin&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-28 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2003 Mar 26;289(12):1523-32 [12672769] Environ Res. 1998 Feb;76(2):107-13 [9515065] Environ Res. 2004 Feb;94(2):120-33 [14757375] Am J Epidemiol. 2001 Jan 15;153(2):164-71 [11159162] N Engl J Med. 2001 May 10;344(19):1421-6 [11346806] J Hum Hypertens. 2002 Feb;16(2):123-31 [11850770] J Hum Hypertens. 2002 Aug;16(8):563-8 [12149662] Am J Ind Med. 2004 May;45(5):446-54 [15095427] Pediatrics. 2004 Jul;114(1):19-26 [15231903] Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76 [15286277] J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):517-9 [739230] Pediatrics. 1979 Apr;63(4):674-6 [440885] Arch Environ Health. 1981 Nov-Dec;36(6):310-5 [7316569] J Lab Clin Med. 1982 Mar;99(3):354-62 [7057062] Proc Soc Exp Biol Med. 1982 May;170(1):63-7 [7043471] Am J Ind Med. 1987;11(2):145-56 [3826077] Med Toxicol. 1987 May-Jun;2(3):210-32 [3298924] Analyst. 1987 Dec;112(12):1701-4 [3445938] J Pediatr. 1988 Oct;113(4):751-7 [2845043] Environ Health Perspect. 1988 Jun;78:71-6 [3060353] Environ Health Perspect. 1988 Jun;78:85-9 [3060355] Am J Dis Child. 1991 Jun;145(6):681-7 [2035497] Paediatr Perinat Epidemiol. 1998 Jul;12(3):313-33 [9690266] Environ Health Perspect. 1998 Nov;106(11):745-50 [9799191] Am J Epidemiol. 2002 Dec 15;156(12):1079-87 [12480651] Hypertension. 2003 Mar;41(3):463-8 [12623944] JAMA. 1992 May 6;267(17):2340-3 [1564773] Epidemiol Rev. 1993;15(2):352-73 [8174662] J Environ Pathol Toxicol Oncol. 1993 Oct-Dec;12(4):213-8 [8189378] Curr Opin Nephrol Hypertens. 1994 May;3(3):257-63 [7922250] J Am Coll Nutr. 1994 Dec;13(6):578-83 [7706590] J Pediatr. 1995 Aug;127(2):186-92 [7636641] Circulation. 1995 Aug 15;92(4):1049-57 [7641339] Epidemiology. 1996 Nov;7(6):633-7 [8899391] N Engl J Med. 1996 Dec 26;335(26):1968-73 [8960478] Hypertension. 2003 Sep;42(3):e9; author reply e9 [12885798] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies. AN - 67816502; 16581542 AB - In rodent cancer bioassays, groups of animals are exposed to different doses of a chemical of interest and followed for tumor occurrence. The resulting tumor rates are commonly analyzed using a survival-adjusted Cochran-Armitage (CA) trend test. The CA trend test has reasonable power when the tumor-response curve is linear in dose, but it may be underpowered for a nonlinear response. An alternative survival-adjusted test procedure based on isotonic regression methodology has previously been proposed. Although this alternative procedure performs well when the tumor response is nonlinear in dose, it has less power than the CA trend test when the response is linear in dose. Here, we introduce a new survival-adjusted test procedure that makes use of both the CA trend test and the isotonic regression-based trend test. Using a broad range of experimental conditions typical of National Toxicology Program (NTP) bioassays, we conducted extensive computer simulations to compare the false-positive error rate and power of the proposed procedure with the survival-adjusted CA trend test. The new procedure competes well with the survival-adjusted CA trend test when observed tumor rates are linear in dose and performs substantially better when observed tumor rates are nonlinear in dose. Further, the proposed trend test almost always has a smaller false-positive rate than does the survival-adjusted CA trend test. We also developed an order-restricted inference-based procedure for performing multiple pairwise comparisons between each of the dose groups and the control group. The trend test and the multiple pairwise comparisons test are demonstrated using an example from a study conducted by the NTP. JF - Environmental health perspectives AU - Peddada, Shyamal D AU - Kissling, Grace E AD - Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. peddada@niehs.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 537 EP - 541 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Nonlinear Dynamics KW - Female KW - Neoplasms, Experimental -- epidemiology KW - Neoplasms, Experimental -- chemically induced KW - Carcinogenicity Tests KW - Survival Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67816502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+survival-adjusted+quantal-response+test+for+analysis+of+tumor+incidence+rates+in+animal+carcinogenicity+studies.&rft.au=Peddada%2C+Shyamal+D%3BKissling%2C+Grace+E&rft.aulast=Peddada&rft.aufirst=Shyamal&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-28 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 2001 Dec;57(4):1219-27 [11764263] Biometrics. 1988 Jun;44(2):417-31 [3390507] Biometrics. 1993 Sep;49(3):793-801 [8241374] Biometrics. 1991 Jun;47(2):681-700 [1912267] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. AN - 67807862; 16288478 AB - Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. This suggests that factors other than a shortage of oxygen may be involved in this induction. Both proteins can also be induced in the presence of oxygen by culturing these cells to a high density without medium change. The intracellular ascorbate measurements revealed its rapid depletion in both metal- and density-exposed cells. Nickel exposure caused strong activation of HIF-1alpha and HIF-2alpha proteins, underscoring activation of HIF-1-dependent transcription. In contrast, cell density-dependent transcription was characterized by minor induction of HIF-1alpha or HIF-2alpha. Moreover, the up-regulation of NDRG1/Cap43 in HIF-1alpha deficient fibroblasts suggested the involvement of different transcription factor(s). The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Thus, the loss of intracellular ascorbate triggered the induction of both tumor markers by two different conditions in the presence of oxygen. Ascorbate is delivered to lung cells via the SVCT2 ascorbate transporter, which was found to be sensitive to nickel or cell density. Collectively these findings establish the importance of intracellular ascorbate levels for the regulation of expression of CA IX and NDRG1/Cap43. We suggest, that, in addition to low oxygenation, insufficient supply of ascorbate or its excessive oxidation in tumors, can contribute to the induction of hypoxia-associated proteins via both HIF-dependent and independent mechanisms. (c) 2005 Wiley-Liss, Inc. JF - Journal of cellular biochemistry AU - Karaczyn, Aldona AU - Ivanov, Sergey AU - Reynolds, Mindy AU - Zhitkovich, Anatoly AU - Kasprzak, Kazimierz S AU - Salnikow, Konstantin AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 1025 EP - 1035 VL - 97 IS - 5 SN - 0730-2312, 0730-2312 KW - Antigens, Neoplasm KW - 0 KW - Cell Cycle Proteins KW - Hypoxia-Inducible Factor 1 KW - Intracellular Signaling Peptides and Proteins KW - N-myc downstream-regulated gene 1 protein KW - Organic Anion Transporters, Sodium-Dependent KW - Proteins KW - SLC23A2 protein, human KW - Sodium-Coupled Vitamin C Transporters KW - Symporters KW - Transcription Factors KW - Lactic Acid KW - 33X04XA5AT KW - Nickel KW - 7OV03QG267 KW - Iron KW - E1UOL152H7 KW - CA9 protein, human KW - EC 4.2.1.1 KW - Carbonic Anhydrase IX KW - Carbonic Anhydrases KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Organic Anion Transporters, Sodium-Dependent -- metabolism KW - Iron -- pharmacology KW - Dose-Response Relationship, Drug KW - Symporters -- metabolism KW - Humans KW - Gene Expression KW - Transcription, Genetic KW - Cell Hypoxia KW - Proteins -- metabolism KW - Hypoxia-Inducible Factor 1 -- metabolism KW - Transfection KW - Antigens, Neoplasm -- metabolism KW - Carbonic Anhydrases -- metabolism KW - Hypoxia-Inducible Factor 1 -- genetics KW - Gene Expression Regulation KW - Lactic Acid -- pharmacology KW - Cell Count KW - Transcription Factors -- metabolism KW - Nickel -- pharmacology KW - Up-Regulation KW - Ascorbic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67807862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+biochemistry&rft.atitle=Ascorbate+depletion+mediates+up-regulation+of+hypoxia-associated+proteins+by+cell+density+and+nickel.&rft.au=Karaczyn%2C+Aldona%3BIvanov%2C+Sergey%3BReynolds%2C+Mindy%3BZhitkovich%2C+Anatoly%3BKasprzak%2C+Kazimierz+S%3BSalnikow%2C+Konstantin&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2006-04-01&rft.volume=97&rft.issue=5&rft.spage=1025&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+biochemistry&rft.issn=07302312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. AN - 67804738; 16502397 AB - This report is a summary of Ron Thurman Symposium on the Mechanisms of Alcohol-Induced Hepatic Fibrosis which was organized by The National Institutes of Health in Santa Barbara, California, June 25, 2005. The Symposium and this report highlight the unique aspects by which drinking alcoholic beverages may result in hepatic fibrosis. Acetaldehyde, the first metabolite of ethanol, can upregulate transcription of collagen I directly as well as indirectly by upregulating the synthesis of transforming growth factor-beta 1 (TGF-beta1). Reactive oxygen species (ROS) generated in hepatocytes by alcohol metabolism can activate collagen production in hepatic stellate cells (HSCs) in a paracrine manner. Alcohol-induced hepatocyte apoptotic bodies can be phagocytosed by HSCs and Kupffer cells and result in increased expression of TGF-beta1 and subsequent HSC activation. Kupffer cells may contribute to the activation of HSCs by releasing ROS and TGF- beta1. Innate immunity may suppress hepatic fibrosis by killing activated HSCs and blocking TGF-beta1 signaling. In patients infected with hepatitis C virus (HCV), alcohol may promote hepatic fibrosis by suppressing innate immunity. HCV core and non-structural proteins contribute to HCV-induced hepatic fibrosis. Alcohol and HCV together may promote hepatic fibrosis through increased oxidative stress and upregulation of fibrogenic cytokines. The inactive aldehyde dehydrogenase (ALDH2) and the super-active alcohol dehydrogenase (ADH2) alleles may promote hepatic fibrosis through increased accumulation of acetaldehyde in the liver. Hepatic fibrosis can be reversed by inducing selective apoptosis or necrosis of activated HSCs, or by reverse trans-differentiation of activated HSCs into the quiescent phenotype. JF - Hepatology (Baltimore, Md.) AU - Purohit, Vishnudutt AU - Brenner, David A AD - Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. vpurohit@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 872 EP - 878 VL - 43 IS - 4 SN - 0270-9139, 0270-9139 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Humans KW - Liver Cirrhosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67804738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Mechanisms+of+alcohol-induced+hepatic+fibrosis%3A+a+summary+of+the+Ron+Thurman+Symposium.&rft.au=Purohit%2C+Vishnudutt%3BBrenner%2C+David+A&rft.aulast=Purohit&rft.aufirst=Vishnudutt&rft.date=2006-04-01&rft.volume=43&rft.issue=4&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-04 N1 - Date created - 2006-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. AN - 67773262; 16377764 AB - The constitutive active receptor (CAR) in mouse primary hepatocytes undergoes okadaic acid (OA)-sensitive nuclear translocation after activation by xenobiotics such as phenobarbital (PB) and 1,4 bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP). We have now mimicked this TCPOBOP-dependent and OA-sensitive translocation of mouse CAR (mCAR) in HepG2 cells and have demonstrated that protein phosphatase 2A regulates this nuclear translocation. Site-directed mutagenesis analysis of various Ser and Thr residues delineated the translocation activity to Ser-202. Mutation of Ser-202 to Asp (S202D) prevented mCAR translocation into the nucleus of TCPOBOP-treated HepG2 cells. In addition, in the livers of Car-/- mice, the YFP-tagged S202D mutant did not translocate into the nucleus after PB treatment. To examine whether Ser-202 can be phosphorylated, flag-tagged wild-type mCAR or flag-tagged S202A mutant was expressed in HepG2 cells and subjected to Western blot analysis using an antibody specific to a peptide containing phospho-Ser-202. A high molecular weight phosphorylated form of CAR was detected only with the wild-type mCAR. These results are consistent with the conclusion that the dephosphorylation of Ser-202 is a required step that regulates the xenobiotic-dependent nuclear translocation of mCAR. JF - Molecular pharmacology AU - Hosseinpour, F AU - Moore, R AU - Negishi, M AU - Sueyoshi, T AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, NIH, Research Triangle Park, NC 2770, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1095 EP - 1102 VL - 69 IS - 4 SN - 0026-895X, 0026-895X KW - Pyridines KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Transcription Factors KW - constitutive androstane receptor KW - Serine KW - 452VLY9402 KW - 1,4-bis(2-(3,5-dichloropyridyloxy))benzene KW - 76150-91-9 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Phenobarbital -- pharmacology KW - Phosphorylation KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Pyridines -- pharmacology KW - Serine -- metabolism KW - Cell Line KW - Protein Transport KW - Transcription Factors -- metabolism KW - Cell Nucleus -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67773262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Serine+202+regulates+the+nuclear+translocation+of+constitutive+active%2Fandrostane+receptor.&rft.au=Hosseinpour%2C+F%3BMoore%2C+R%3BNegishi%2C+M%3BSueyoshi%2C+T&rft.aulast=Hosseinpour&rft.aufirst=F&rft.date=2006-04-01&rft.volume=69&rft.issue=4&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. AN - 67772114; 16339183 AB - Although the toxicity of benzene has been linked to its metabolism, the dose-related production of metabolites is not well understood in humans, particularly at low levels of exposure. We investigated unmetabolized benzene in urine (UBz) and all major urinary metabolites [phenol (PH), E,E-muconic acid (MA), hydroquinone (HQ) and catechol (CA)] as well as the minor metabolite, S-phenylmercapturic acid (SPMA), in 250 benzene-exposed workers and 139 control workers in Tianjin, China. Median levels of benzene exposure were approximately 1.2 p.p.m. for exposed workers (interquartile range: 0.53-3.34 p.p.m.) and 0.004 p.p.m. for control workers (interquartile range: 0.002-0.007 p.p.m.). (Exposures of control workers to benzene were predicted from levels of benzene in their urine.) Metabolite production was investigated among groups of 30 workers aggregated by their benzene exposures. We found that the urine concentration of each metabolite was consistently elevated when the group's median benzene exposure was at or above the following air concentrations: 0.2 p.p.m. for MA and SPMA, 0.5 p.p.m. for PH and HQ, and 2 p.p.m. for CA. Dose-related production of the four major metabolites and total metabolites (micromol/l/p.p.m. benzene) declined between 2.5 and 26-fold as group median benzene exposures increased between 0.027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures. JF - Carcinogenesis AU - Kim, Sungkyoon AU - Vermeulen, Roel AU - Waidyanatha, Suramya AU - Johnson, Brent A AU - Lan, Qing AU - Rothman, Nathaniel AU - Smith, Martyn T AU - Zhang, Luoping AU - Li, Guilan AU - Shen, Min AU - Yin, Songnian AU - Rappaport, Stephen M AD - School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 772 EP - 781 VL - 27 IS - 4 SN - 0143-3334, 0143-3334 KW - Catechols KW - 0 KW - Hydroquinones KW - Phenol KW - 339NCG44TV KW - muconic acid KW - 3KD92ZL2KH KW - S-phenyl-N-acetylcysteine KW - 4775-80-8 KW - Benzene KW - J64922108F KW - catechol KW - LF3AJ089DQ KW - Acetylcysteine KW - WYQ7N0BPYC KW - Sorbic Acid KW - X045WJ989B KW - hydroquinone KW - XV74C1N1AE KW - Index Medicus KW - Acetylcysteine -- analogs & derivatives KW - Dose-Response Relationship, Drug KW - Humans KW - Phenol -- urine KW - Hydroquinones -- urine KW - Catechols -- urine KW - Acetylcysteine -- urine KW - Sorbic Acid -- analogs & derivatives KW - Adult KW - Case-Control Studies KW - Sorbic Acid -- analysis KW - Middle Aged KW - Urinalysis KW - Adolescent KW - Female KW - Male KW - Occupational Exposure KW - Benzene -- metabolism KW - Benzene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67772114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Using+urinary+biomarkers+to+elucidate+dose-related+patterns+of+human+benzene+metabolism.&rft.au=Kim%2C+Sungkyoon%3BVermeulen%2C+Roel%3BWaidyanatha%2C+Suramya%3BJohnson%2C+Brent+A%3BLan%2C+Qing%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BLi%2C+Guilan%3BShen%2C+Min%3BYin%2C+Songnian%3BRappaport%2C+Stephen+M&rft.aulast=Kim&rft.aufirst=Sungkyoon&rft.date=2006-04-01&rft.volume=27&rft.issue=4&rft.spage=772&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action. AN - 67770924; 16234259 AB - LRAT (lecithin:retinol acyltransferase), an enzyme whose levels are modulated during malignant conversion, has been reported as the founder member of a new LRAT-like family that includes tumor suppressors TIG-3(1-164) and Ha-Rev107(1-162). The mechanisms that link these three proteins to carcinogenesis as well as the significance of a reported shared sequence homologous region remain unclear. This begs the question if the tumor suppressors possess enzyme properties and/or if the LRAT enzyme possesses tumor suppressor properties. We use the reported homologous region as a first approach to address the question from the perspective that all three proteins can possess tumor suppressor properties. We postulated that the homologous sequence harbors an anti-proliferation domain within the full-length proteins and that dodecapeptides of this sequence possess anti-proliferative activity. We report that H-TIG-3(111-123), H-Ha-Rev107-1(111-123) and H-LRAT160-171:C168L exhibited in vitro growth inhibitory activity in a human cutaneous melanoma (HCM) model and affected tumor growth in a nude mouse model. Further, in peptide-sensitive HCM cells, these peptides crossed the plasma membrane and localized to the nucleus, where they could bind and activate promoters of transcription factors involved in G1-->S transition. Moreover, peptide-induced abrogation of cyclin dependent kinase-2 expression was concomitant with sub-cellular re-distribution of cyclins E and A. Indeed, the sequence homologous region within each full-length wild-type protein as well as the growth inhibitory peptides can form alpha helices, a likely configuration for binding to DNA. This is the first report that this sequence homologous region (AA111-123) within these LRAT-like proteins harbors an anti-proliferative domain with DNA binding properties. Sequences from this sequence homologous region can be used as templates for anti-tumor drug design and as probes to investigate disease-related mechanisms and structure-activity relationships of the full-length proteins, TIG-3(1-164), Ha-Rev107(1-162) and LRAT160-171. JF - Carcinogenesis AU - Simmons, Denise Perry AU - Peach, Megan L AU - Friedman, Jonathan R AU - Green, Michael M B AU - Nicklaus, Marc C AU - De Luca, Luigi M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 693 EP - 707 VL - 27 IS - 4 SN - 0143-3334, 0143-3334 KW - Antineoplastic Agents KW - 0 KW - Peptides KW - Tumor Suppressor Proteins KW - Acyltransferases KW - EC 2.3.- KW - lecithin-retinol acyltransferase KW - EC 2.3.1.- KW - Index Medicus KW - Animals KW - Melanoma -- pathology KW - Tumor Cells, Cultured KW - Tumor Suppressor Proteins -- physiology KW - Humans KW - Transplantation, Heterologous KW - Skin Neoplasms -- pathology KW - Mice, Nude KW - Mice KW - Mice, Inbred BALB C KW - Antineoplastic Agents -- pharmacology KW - Female KW - Cell Transformation, Neoplastic KW - Protein Biosynthesis KW - Sequence Homology KW - Acyltransferases -- metabolism KW - Cell Proliferation KW - Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67770924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Evidence+that+sequence+homologous+region+in+LRAT-like+proteins+possesses+anti-proliferative+activity+and+DNA+binding+properties%3A+translational+implications+and+mechanism+of+action.&rft.au=Simmons%2C+Denise+Perry%3BPeach%2C+Megan+L%3BFriedman%2C+Jonathan+R%3BGreen%2C+Michael+M+B%3BNicklaus%2C+Marc+C%3BDe+Luca%2C+Luigi+M&rft.aulast=Simmons&rft.aufirst=Denise&rft.date=2006-04-01&rft.volume=27&rft.issue=4&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. AN - 67770660; 16418338 AB - Evidence that the ligand binding site of TRPV1 lies on the inner face of the plasma membrane and that much of the TRPV1 itself is localized to internal membranes suggests that the rate of ligand entry into the cell may be an important determinant of the kinetics of ligand action. In this study, we synthesized a BODIPY TR-labeled fluorescent capsaicin analog (CHK-884) so that we could directly measure ligand entry. We report that CHK-884 penetrated only slowly into Chinese hamster ovary (CHO) cells expressing rat TRPV1, with a t1/2 of 30 +/- 4 min, and localized in the endoplasmic reticulum and Golgi. Although CHK-884 was only weakly potent for TRPV1 binding (Ki = 6400 +/- 230 nM), it was appreciably more potent when assayed by intracellular calcium imaging and was 3.2-fold more potent with a 1-h incubation time (37 nM) than with a 5-min incubation time. Olvanil, a highly lipophilic vanilloid, yielded an EC50 of 4.3 nM upon intracellular calcium imaging with an incubation time of 1 h, compared with an EC50 value of 29.5 nM for calcium imaging assayed at 5 min. Likewise, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2 pM if incubated with CHO-TRPV1 cells for 2 h before addition of capsaicin compared with 1.5 nM if added simultaneously. We conclude that some vanilloids may have slow kinetics of uptake; this slow uptake may affect assessment of structure activity relations and may represent a significant factor for vanilloid drug design. JF - Molecular pharmacology AU - Lazar, Jozsef AU - Braun, Derek C AU - Tóth, Attila AU - Wang, Yun AU - Pearce, Larry V AU - Pavlyukovets, Vladimir A AU - Blumberg, Peter M AU - Garfield, Susan H AU - Wincovitch, Stephen AU - Choi, Hyun-Kyung AU - Lee, Jeewoo AD - Molecular Mechanism of Tumor Promotion, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bldg. 37, Room 4048, 37 Convent Drive, MSC 4255, Bethesda, MD 20892-4255, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 1166 EP - 1173 VL - 69 IS - 4 SN - 0026-895X, 0026-895X KW - Benzaldehydes KW - 0 KW - TRPV Cation Channels KW - TRPV1 protein, human KW - vanillin KW - CHI530446X KW - Index Medicus KW - Molecular Structure KW - Microscopy, Confocal KW - Animals KW - CHO Cells KW - Cricetinae KW - Benzaldehydes -- pharmacokinetics KW - TRPV Cation Channels -- drug effects KW - Benzaldehydes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67770660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Kinetics+of+penetration+influence+the+apparent+potency+of+vanilloids+on+TRPV1.&rft.au=Lazar%2C+Jozsef%3BBraun%2C+Derek+C%3BT%C3%B3th%2C+Attila%3BWang%2C+Yun%3BPearce%2C+Larry+V%3BPavlyukovets%2C+Vladimir+A%3BBlumberg%2C+Peter+M%3BGarfield%2C+Susan+H%3BWincovitch%2C+Stephen%3BChoi%2C+Hyun-Kyung%3BLee%2C+Jeewoo&rft.aulast=Lazar&rft.aufirst=Jozsef&rft.date=2006-04-01&rft.volume=69&rft.issue=4&rft.spage=1166&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-19 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Projecting drug use among aging baby boomers in 2020. AN - 67761887; 16275134 AB - Greater rates of lifetime drug use among the baby-boom generation, combined with the size of that generation, suggest that the number of elderly persons using drugs will increase in the next two decades. Given the potential public health demands implied by increasing numbers of elderly drug users, the goal is to project the numbers of current drug users aged 50 years and older in 2020. Using the modeling and projection methods of Gfroerer et al (2003) applied to data from the 1999 to 2001 National Household Surveys on Drug Abuse, projections were developed for the use of marijuana, nonmedical use of any prescription-type psychotherapeutic drug, and any illicit drug use. From 1999 to 2001 to 2020, past-year marijuana use in persons 50 years and older is forecast to increase from 1.0% to 2.9%. The number of users is expected to increase from 719,000 to almost 3.3 million, reflecting the combined effects of the increase in rate of use and a projected 51.9% increase in the civilian noninstitutionalized population in this age group. Use of any illicit drug will increase from 2.2% (1.6 million) to 3.1% (3.5 million), and nonmedical use of psychotherapeutic drugs will increase from 1.2% (911,000) to 2.4% (almost 2.7 million). These projections call attention to changes to be considered in planning and to the need for improved knowledge of the biomedical and psychosocial effects of nonmedical drug use on aging and elderly individuals. JF - Annals of epidemiology AU - Colliver, James D AU - Compton, Wilson M AU - Gfroerer, Joseph C AU - Condon, Timothy AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 257 EP - 265 VL - 16 IS - 4 SN - 1047-2797, 1047-2797 KW - Index Medicus KW - Odds Ratio KW - Age of Onset KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Data Collection KW - United States -- epidemiology KW - Male KW - Female KW - Cohort Effect KW - Forecasting KW - Health Services Needs and Demand -- trends KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67761887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Projecting+drug+use+among+aging+baby+boomers+in+2020.&rft.au=Colliver%2C+James+D%3BCompton%2C+Wilson+M%3BGfroerer%2C+Joseph+C%3BCondon%2C+Timothy&rft.aulast=Colliver&rft.aufirst=James&rft.date=2006-04-01&rft.volume=16&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular prognostication of liver cancer: end of the beginning. AN - 67758362; 16488507 JF - Journal of hepatology AU - Thorgeirsson, Snorri S AU - Lee, Ju-Seog AU - Grisham, Joe W AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892-4262, USA. snorri_thorgeirsson@nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 798 EP - 805 VL - 44 IS - 4 SN - 0168-8278, 0168-8278 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - DNA, Neoplasm -- genetics KW - Predictive Value of Tests KW - Recurrence KW - Gene Expression Profiling KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- classification KW - Liver Neoplasms -- diagnosis KW - Liver Neoplasms -- classification KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67758362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Molecular+prognostication+of+liver+cancer%3A+end+of+the+beginning.&rft.au=Thorgeirsson%2C+Snorri+S%3BLee%2C+Ju-Seog%3BGrisham%2C+Joe+W&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of sex-related differences in saquinavir pharmacokinetics in an HIV-seronegative cohort. AN - 67752636; 16542198 AB - To examine the influence of sex on steady-state saquinavir pharmacokinetics in HIV-seronegative volunteers administered saquinavir without a concomitant protease inhibitor. Thirty-eight healthy volunteers (14 female) received saquinavir soft-gel capsules 1200 mg three times daily for 3 days to achieve steady-state conditions. Following administration of the 10th dose, blood was collected serially over 8 h for measurement of saquinavir plasma concentrations. Saquinavir pharmacokinetic parameter values were determined using noncompartmental methods and compared between males and females. CYP3A phenotype (using oral midazolam) and MDR-1 genotypes at positions 3435 and 2677 were determined for all subjects in order to characterize possible mechanisms for any observed sex-related differences. There was no significant difference in saquinavir AUC(0-8) or any other pharmacokinetic parameter value between the sexes. These findings persisted after mathematically correcting for total body weight. The mean weight-normalized AUC(0-8) was 29.9 (95% confidence interval 15.5, 44.3) and 29.8 (18.6, 40.9) ng h(-1) ml(-1) kg(-1) for males and females, respectively. No significant difference in CYP3A phenotype was observed between the groups; likewise, the distribution of MDR-1 genotypes was similar for males and females. In contrast to previous study findings, results from this investigation showed no difference in saquinavir pharmacokinetics between males and females. The discrepancy between our findings and those previously reported may be explained by the fact that we evaluated HIV-seronegative volunteers and administered saquinavir in the absence of concomitant protease inhibitors such as ritonavir. Caution must be exercised when extrapolating pharmacokinetic data from healthy volunteer studies (including sex-based pharmacokinetic differences) to HIV-infected populations or to patients receiving additional concurrent medications. JF - British journal of clinical pharmacology AU - Robertson, Sarah M AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Natarajan, Ven AU - Falloon, Judith AU - Penzak, Scott R AD - Clinical Research Center, Department of Critical Care Medicine, National Institutes of Health, Bethesda, MD 20892, USA. robertsonsa@cc.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 379 EP - 388 VL - 61 IS - 4 SN - 0306-5251, 0306-5251 KW - HIV Protease Inhibitors KW - 0 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Saquinavir KW - L3JE09KZ2F KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Administration, Oral KW - Genes, MDR -- genetics KW - Sex Factors KW - Area Under Curve KW - Midazolam -- blood KW - Humans KW - Cytochrome P-450 CYP3A -- genetics KW - Phenotype KW - Genotype KW - Midazolam -- administration & dosage KW - Adult KW - Cohort Studies KW - Middle Aged KW - Female KW - Male KW - Saquinavir -- blood KW - HIV Seronegativity -- physiology KW - HIV Seronegativity -- genetics KW - HIV Protease Inhibitors -- blood KW - HIV Protease Inhibitors -- pharmacokinetics KW - Saquinavir -- adverse effects KW - HIV Protease Inhibitors -- adverse effects KW - Saquinavir -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67752636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+clinical+pharmacology&rft.atitle=Lack+of+sex-related+differences+in+saquinavir+pharmacokinetics+in+an+HIV-seronegative+cohort.&rft.au=Robertson%2C+Sarah+M%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BNatarajan%2C+Ven%3BFalloon%2C+Judith%3BPenzak%2C+Scott+R&rft.aulast=Robertson&rft.aufirst=Sarah&rft.date=2006-04-01&rft.volume=61&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=British+journal+of+clinical+pharmacology&rft.issn=03065251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-11 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2000 Jan;292(1):310-8 [10604964] J Chromatogr. 1991 Nov 15;571(1-2):298-304 [1810961] AIDS. 2000 Jun 16;14(9):1287-9 [10894301] Pharmacotherapy. 2000 Aug;20(8):898-907 [10939550] Eur J Clin Pharmacol. 2000 Jun;56(3):231-40 [10952478] Antimicrob Agents Chemother. 2000 Oct;44(10):2672-8 [10991842] J Pharmacol Exp Ther. 2001 Jun;297(3):1137-43 [11356939] Eur J Clin Pharmacol. 2001 May;57(2):115-21 [11417442] Clin Pharmacol Ther. 2001 Aug;70(2):189-99 [11503014] AIDS Res Hum Retroviruses. 2001 Sep 20;17(14):1329-32 [11602043] Clin Infect Dis. 2002 Jan 15;34(2):234-8 [11740713] Pharmacogenetics. 2001 Dec;11(9):781-91 [11740342] J Pharm Sci. 2001 Nov;90(11):1829-37 [11745741] J Acquir Immune Defic Syndr. 2002 Jan 1;29(1):101-2 [11782597] Pharmacol Ther. 2001 Nov-Dec;92(2-3):147-63 [11916535] Clin Pharmacokinet. 2002;41(4):235-53 [11978143] HIV Med. 2002 Apr;3(2):97-104 [12010356] Clin Pharmacokinet. 2002;41(5):329-42 [12036391] Clin Pharmacol Ther. 2002 Aug;72(2):209-19 [12189368] Clin Pharmacol Ther. 2002 Nov;72(5):474-89 [12426511] Clin Pharmacol Ther. 2002 Nov;72(5):584-94 [12426522] Adv Drug Deliv Rev. 2003 Jan 21;55(1):3-29 [12535572] Adv Drug Deliv Rev. 2003 Jan 21;55(1):53-81 [12535574] Transplant Proc. 1996 Aug;28(4):2159-61 [8769186] J Pharmacol Exp Ther. 1994 Jul;270(1):414-23 [8035341] Clin Pharmacol Ther. 1994 Oct;56(4):368-76 [7955798] Biochem Pharmacol. 1995 Aug 25;50(5):727-30 [7669077] J Pharmacol Exp Ther. 1995 Nov;275(2):1011-8 [7473127] J Clin Invest. 1998 Jan 15;101(2):289-94 [9435299] Clin Pharmacol Ther. 1998 Aug;64(2):133-43 [9728893] J Pharm Biomed Anal. 2004 Nov 19;36(4):835-40 [15533677] J Neuropathol Exp Neurol. 2004 Oct;63(10):1038-47 [15535131] Drug Metab Dispos. 2005 Mar;33(3):426-33 [15608139] Pharmacogenomics. 2003 Jul;4(4):397-410 [12831320] Hepatology. 2003 Oct;38(4):978-88 [14512885] Annu Rev Pharmacol Toxicol. 2004;44:499-523 [14744256] J Infect Dis. 2004 Apr 1;189(7):1176-84 [15031785] Pharmacotherapy. 2004 May;24(5):592-9 [15162893] Ther Drug Monit. 2004 Jun;26(3):322-30 [15167636] Ther Drug Monit. 2004 Apr;26(2):104-6 [15228147] Antimicrob Agents Chemother. 2004 Nov;48(11):4256-62 [15504850] Clin Pharmacol Ther. 1986 May;39(5):489-90 [3698457] Clin Pharmacol Ther. 1990 Oct;48(4):365-74 [2121408] J Clin Pharmacol. 2000 Mar;40(3):219-30 [10709150] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Salivary gland gene therapy. AN - 67743373; 16530055 AB - Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract. JF - Dental clinics of North America AU - Cotrim, Ana P AU - Mineshiba, Fumi AU - Sugito, Takayuki AU - Samuni, Yuval AU - Baum, Bruce J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1190, USA. Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 157 EP - 73, vii VL - 50 IS - 2 SN - 0011-8532, 0011-8532 KW - Proteins KW - 0 KW - Dentistry KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Head and Neck Neoplasms -- complications KW - Sjogren's Syndrome -- therapy KW - Radiation Injuries -- therapy KW - Head and Neck Neoplasms -- radiotherapy KW - Proteins -- metabolism KW - Proteins -- genetics KW - Sjogren's Syndrome -- genetics KW - Salivary Glands -- injuries KW - Salivary Gland Diseases -- therapy KW - Salivary Gland Diseases -- complications KW - Genetic Therapy -- methods KW - Drug Delivery Systems -- methods KW - Salivary Glands -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67743373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dental+clinics+of+North+America&rft.atitle=Salivary+gland+gene+therapy.&rft.au=Cotrim%2C+Ana+P%3BMineshiba%2C+Fumi%3BSugito%2C+Takayuki%3BSamuni%2C+Yuval%3BBaum%2C+Bruce+J&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=50&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Dental+clinics+of+North+America&rft.issn=00118532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. AN - 67740675; 16483848 AB - Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic formation of advanced glycation end products. Many of these pathways become activated in response to the production of superoxide anion. Superoxide can interact with nitric oxide, forming the potent cytotoxin peroxynitrite. Peroxynitrite attacks various biomolecules in the vascular endothelium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via multiple mechanisms. This review focuses on emerging evidence suggesting that peroxynitrite plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic retinopathy, neuropathy and nephropathy. JF - Current opinion in pharmacology AU - Pacher, Pál AU - Szabó, Csaba AD - National Institutes of Health, NIAAA, Laboratory of Physiologic Studies, 5625 Fishers Lane MSC 9413, Bethesda, Maryland 20852, USA. pacher@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 136 EP - 141 VL - 6 IS - 2 SN - 1471-4892, 1471-4892 KW - Peroxynitrous Acid KW - 14691-52-2 KW - Index Medicus KW - Animals KW - Atherosclerosis -- etiology KW - Humans KW - Male KW - Female KW - Peroxynitrous Acid -- adverse effects KW - Oxidative Stress -- physiology KW - Diabetes Complications -- etiology KW - Cardiomyopathies -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67740675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pharmacology&rft.atitle=Role+of+peroxynitrite+in+the+pathogenesis+of+cardiovascular+complications+of+diabetes.&rft.au=Pacher%2C+P%C3%A1l%3BSzab%C3%B3%2C+Csaba&rft.aulast=Pacher&rft.aufirst=P%C3%A1l&rft.date=2006-04-01&rft.volume=6&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pharmacology&rft.issn=14714892&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-03 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Circulation. 2002 Apr 9;105(14):1656-62 [11940543] Diabetes. 2002 Apr;51(4):1076-82 [11916928] Diabetologia. 2002 Apr;45(4):476-94 [12032623] Diabetes Care. 2002 Aug;25(8):1439-43 [12145247] Circulation. 2002 Sep 3;106(10):1211-8 [12208795] Pharmacol Rev. 2002 Sep;54(3):375-429 [12223530] J Am Coll Cardiol. 2002 Sep 4;40(5):1006-16 [12225730] Circulation. 2002 Nov 19;106(21):2680-6 [12438293] Mol Med. 2002 Oct;8(10):571-80 [12477967] Biochem Pharmacol. 2003 Apr 1;65(7):1189-97 [12663054] Circulation. 2003 Feb 25;107(7):1017-23 [12600916] Circulation. 2003 Feb 18;107(6):896-904 [12591762] Diabetes Care. 2003 May;26(5):1589-96 [12716823] Am J Pathol. 2003 Jun;162(6):1995-2004 [12759255] Invest Ophthalmol Vis Sci. 2003 Jul;44(7):3135-43 [12824263] Free Radic Biol Med. 2003 Sep 15;35(6):683-94 [12957660] Trends Pharmacol Sci. 2003 Sep;24(9):471-8 [12967772] J Clin Invest. 2003 Oct;112(7):1049-57 [14523042] Diabetologia. 2003 Oct;46(10):1419-27 [12898015] JAMA. 2003 Oct 8;290(14):1884-90 [14532317] Mol Med. 2004 Jan-Jun;10(1-6):28-35 [15502880] FASEB J. 1992 Aug;6(11):2905-14 [1644256] Am J Physiol. 1996 Nov;271(5 Pt 1):C1424-37 [8944624] Circulation. 1997 Jul 1;96(1):25-8 [9236411] FEBS Lett. 1997 Jul 14;411(2-3):157-60 [9271196] Diabetologia. 1999 May;42(5):539-44 [10333045] Diabetes. 1999 Sep;48(9):1856-62 [10480619] Diabetes. 2005 Jan;54(1):234-42 [15616034] Curr Med Chem. 2005;12(3):267-75 [15723618] FASEB J. 2005 Mar;19(3):401-3 [15611153] Curr Opin Pharmacol. 2005 Apr;5(2):143-8 [15780822] Nat Rev Drug Discov. 2005 May;4(5):421-40 [15864271] Diabetes. 2005 Jun;54(6):1829-37 [15919806] Trends Pharmacol Sci. 2005 Jun;26(6):302-10 [15925705] Diabetes. 2005 Dec;54(12):3435-41 [16306359] Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1568-80 [16356120] J Neurochem. 2002 Mar;80(5):771-9 [11948240] Nature. 2000 Apr 13;404(6779):787-90 [10783895] Kidney Int. 2000 May;57(5):1968-72 [10792615] J Cardiovasc Pharmacol. 2000 Aug;36(2):182-7 [10942159] Circ Res. 2000 Dec 8;87(12):1123-32 [11110769] Nat Med. 2001 Jan;7(1):108-13 [11135624] Endocr Rev. 2001 Feb;22(1):36-52 [11159815] Cardiovasc Res. 2001 Mar;49(4):798-807 [11230979] J Clin Invest. 2001 Apr;107(7):853-60 [11285304] Diabetes. 2001 Jun;50(6):1414-24 [11375343] Diabetologia. 2001 Jul;44(7):834-8 [11508267] Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2289-94 [11709394] Nature. 2001 Dec 13;414(6865):813-20 [11742414] Diabetes. 2002 Jan;51(1):198-203 [11756341] Kidney Int. 2002 Jan;61(1):186-94 [11786100] Diabetes. 2002 Feb;51(2):514-21 [11812763] Erratum In: Curr Opin Pharmacol. 2006 Jun;6(3):319 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nurses' collaboration with physicians in managing medication improves patient outcome in acute psychiatric care AN - 57202583; 200710676 AB - Abstract The aim of the present paper was to examine the impact of nurses' collaboration with physicians in medication management on patient outcome in acute psychiatric care. Data for 143 patients with schizophrenia were assessed based on information given by nurses and physicians in charge. Twenty-two patients were defined as a collaborative group when physicians changed medication after receiving reports that nurses perceived the necessity to change. A control group was formed from the 50 patients when nurses perceived the necessity to change medication but did not tell physicians, or nurses advised of the necessity to physicians but medication was not changed. Physicians retrospectively evaluated patients' social functioning and acceptance of medication at admission and discharge. Social functioning was measured by Global Assessment of Functioning (GAF), and acceptance of medication by a single item using Japanese version of Schedule for Assessment of Insight (SAI-J). Changes in the scores from admission to discharge on GAF and acceptance of medication were defined as outcome measures. Nurses recognized the necessity to change medication for patients with frequent aggressive behavior and younger age. Compared with the control group, the collaborative group had less instruction for use of drugs, and more perceived necessity to decrease the current dose or the number of drugs because of stable symptoms. The collaborative group demonstrated significantly greater improvement in social functioning. The collaborative group improved acceptance of medication, although there were no significant differences between the two groups. Nurses' collaboration with physicians in medication management improved patient outcome in acute psychiatric care. Tables, Figures, 3, References. Adapted from the source document. JF - Psychiatry and Clinical Neurosciences AU - Nakanishi, Miharu AU - Koyama, Asuka AU - Ito, Hiroto AU - Kurita, Hiroshi AU - Higuchi, Teruhiko AD - Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 196 EP - 203 PB - Blackwell Publishing Asia, Carlton South Australia VL - 60 IS - 2 SN - 1323-1316, 1323-1316 KW - acute psychiatric care KW - collaboration KW - medication management KW - nurse KW - physician KW - schizophrenia KW - Doctor-Nurse collaboration KW - Management KW - Health care KW - Psychiatric disorders KW - Drugs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57202583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+Clinical+Neurosciences&rft.atitle=Nurses%27+collaboration+with+physicians+in+managing+medication+improves+patient+outcome+in+acute+psychiatric+care&rft.au=Nakanishi%2C+Miharu%3BKoyama%2C+Asuka%3BIto%2C+Hiroto%3BKurita%2C+Hiroshi%3BHiguchi%2C+Teruhiko&rft.aulast=Nakanishi&rft.aufirst=Miharu&rft.date=2006-04-01&rft.volume=60&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+Clinical+Neurosciences&rft.issn=13231316&rft_id=info:doi/10.1111%2Fj.1440-1819.2006.01486.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PCNEFP N1 - SubjectsTermNotLitGenreText - Doctor-Nurse collaboration; Health care; Drugs; Management; Psychiatric disorders DO - http://dx.doi.org/10.1111/j.1440-1819.2006.01486.x ER - TY - JOUR T1 - Twelve-month use of mental health services in four areas in Japan: Findings from the World Mental Health Japan Survey 2002-2003 AN - 57169010; 200710674 AB - Abstract The aim of the present study was to provide basic descriptive data regarding utilization of 12-month mental health services in the Japanese community population. Face-to-face household surveys were carried out in four areas (two urban cities and two rural municipalities), and a total of 1663 persons participated (overall response rate: 56.4%). For data collection, the structured psychiatric interview, World Mental Health version of the World Health Organization Composite International Diagnostic Interview (WMH-CIDI) was used, allowing DSM-IV diagnoses, severity, and service utilization. It was found that 7.3% of total respondents had received any service, either professional or non-professional, in the past 12 months, including 20.0% of those with 12-month DSM-IV disorders and 6.2% of those without. Thirty-three percent of those with any mood disorder used any service, and 26.8% of those used some type of health care. The probability of people with 13-15 years of education receiving mental health treatment was fourfold higher than those with >=16 years of education. Gender, age, or income were not found to contribute to utilization of mental health services. The results confirm that the majority of people with a recent psychiatric disorder have not used mental health care or other support systems. The mental health care system in Japan has improved over the past decade, but not enough for people suffering from mental disturbances. Tables, 2, References. Adapted from the source document. JF - Psychiatry and Clinical Neurosciences AU - Naganuma, Yoichi AU - TACHIMORI, HISATERU AU - Kawakami, Norito AU - Takeshima, Tadashi AU - Ono, Yutaka AU - Uda, Hidenori AU - Hata, Yukihiro AU - Nakane, Yoshibumi AU - Nakane, Hideyuki AU - Iwata, Noboru AU - Furukawa, Toshiaki A AU - Kikkawa, Takehiko AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 240 EP - 248 PB - Blackwell Publishing Asia, Carlton South Australia VL - 60 IS - 2 SN - 1323-1316, 1323-1316 KW - CIDI KW - descriptive epidemiology KW - mental disorders KW - service use KW - WMH surveys KW - Mental health care KW - Mental health services KW - Epidemiology KW - Psychiatric disorders KW - Surveys KW - Japan KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57169010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+Clinical+Neurosciences&rft.atitle=Twelve-month+use+of+mental+health+services+in+four+areas+in+Japan%3A+Findings+from+the+World+Mental+Health+Japan+Survey+2002-2003&rft.au=Naganuma%2C+Yoichi%3BTACHIMORI%2C+HISATERU%3BKawakami%2C+Norito%3BTakeshima%2C+Tadashi%3BOno%2C+Yutaka%3BUda%2C+Hidenori%3BHata%2C+Yukihiro%3BNakane%2C+Yoshibumi%3BNakane%2C+Hideyuki%3BIwata%2C+Noboru%3BFurukawa%2C+Toshiaki+A%3BKikkawa%2C+Takehiko&rft.aulast=Naganuma&rft.aufirst=Yoichi&rft.date=2006-04-01&rft.volume=60&rft.issue=2&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+Clinical+Neurosciences&rft.issn=13231316&rft_id=info:doi/10.1111%2Fj.1440-1819.2006.01492.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PCNEFP N1 - SubjectsTermNotLitGenreText - Mental health services; Epidemiology; Psychiatric disorders; Japan; Surveys; Mental health care DO - http://dx.doi.org/10.1111/j.1440-1819.2006.01492.x ER - TY - JOUR T1 - Analysis of Repeated Pregnancy Outcomes AN - 57168836; 200609038 AB - Women tend to repeat reproductive outcomes, with past history of an adverse outcome being associated with an approximate two-fold increase in subsequent risk. These observations support the need for statistical designs & analyses that address this clustering. Failure to do so may mask effects, result in inaccurate variance estimators, produce biased or inefficient estimates of exposure effects. We review & evaluate basic analytic approaches for analysing reproductive outcomes, including ignoring reproductive history, treating it as a covariate or avoiding the clustering problem by analysing only one pregnancy per woman, & contrast these to more modern approaches such as generalized estimating equations with robust standard errors & mixed models with various correlation structures. We illustrate the issues by analysing a sample from the Collaborative Perinatal Project dataset, demonstrating how the statistical model impacts summary statistics & inferences when assessing etiologic determinants of birth weight. 6 Tables, 1 Figure, 37 References. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Louis, Germaine Buck AU - Dukic, Vanja AU - Heagerty, Patrick J AU - Louis, Thomas A AU - Lynch, Courtney D AU - Ryan, Louise M AU - Schisterman, Enrique F AU - Trumble, Ann AU - Pregnancy Modeling Working Group AD - Division Epidemiology/Statistics/Prevention Research, National Instit Child Health & Human Development, Rock louisg@mail.nih.gov; Pregnancy Modeling Working Group Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 103 EP - 126 PB - Hodder Arnold, London UK VL - 15 IS - 2 SN - 0962-2802, 0962-2802 KW - Outcomes KW - Statistical analysis KW - Medical history KW - Risks KW - Pregnancy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57168836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Analysis+of+Repeated+Pregnancy+Outcomes&rft.au=Louis%2C+Germaine+Buck%3BDukic%2C+Vanja%3BHeagerty%2C+Patrick+J%3BLouis%2C+Thomas+A%3BLynch%2C+Courtney+D%3BRyan%2C+Louise+M%3BSchisterman%2C+Enrique+F%3BTrumble%2C+Ann%3BPregnancy+Modeling+Working+Group&rft.aulast=Louis&rft.aufirst=Germaine&rft.date=2006-04-01&rft.volume=15&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1191%2F0962280206sm434oa LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Pregnancy; Outcomes; Medical history; Risks; Statistical analysis DO - http://dx.doi.org/10.1191/0962280206sm434oa ER - TY - CPAPER T1 - Medical History and Risk of Multiple Myeloma in Connecticut Women T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40060738; 4181905 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Landgren, Ola AU - Zhang, Yawei AU - Zahm, Sheila Hoar AU - Inskip, Peter AU - Zheng, Tongzhang AU - Baris, Dalsu Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - USA, Connecticut KW - Historical account KW - Multiple myeloma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40060738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Medical+History+and+Risk+of+Multiple+Myeloma+in+Connecticut+Women&rft.au=Landgren%2C+Ola%3BZhang%2C+Yawei%3BZahm%2C+Sheila+Hoar%3BInskip%2C+Peter%3BZheng%2C+Tongzhang%3BBaris%2C+Dalsu&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prediction of Breast Cancer Outcome by p53 Depends on MDM2 SNP309 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40027517; 4183750 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Boersma, Brenda J AU - Howe, Tiffany AU - Goodman, Julie AU - Yfantis, Harry AU - Prueitt, Robyn AU - Lee, Dong AU - Chanock, Stephen AU - Ambs, Stefan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - P53 protein KW - MDM2 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Prediction+of+Breast+Cancer+Outcome+by+p53+Depends+on+MDM2+SNP309&rft.au=Boersma%2C+Brenda+J%3BHowe%2C+Tiffany%3BGoodman%2C+Julie%3BYfantis%2C+Harry%3BPrueitt%2C+Robyn%3BLee%2C+Dong%3BChanock%2C+Stephen%3BAmbs%2C+Stefan&rft.aulast=Boersma&rft.aufirst=Brenda&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Smad3 Reduces Susceptibility to Hepatocarcinoma by Sensitizing Hepatocytes to Apoptosis through Down-Regulation of Bcl-2 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40027292; 4186904 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Yu-an AU - Zhang, Gen-Mu AU - Feigenbaum, Lionel AU - Cheng, Steven Y AU - Zhang, Ying E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bcl-2 protein KW - Apoptosis KW - Hepatocytes KW - Smad3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Smad3+Reduces+Susceptibility+to+Hepatocarcinoma+by+Sensitizing+Hepatocytes+to+Apoptosis+through+Down-Regulation+of+Bcl-2&rft.au=Yang%2C+Yu-an%3BZhang%2C+Gen-Mu%3BFeigenbaum%2C+Lionel%3BCheng%2C+Steven+Y%3BZhang%2C+Ying+E&rft.aulast=Yang&rft.aufirst=Yu-an&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Knockdown of p97 Valosin-Containing Protein by siRNA Interference Deconstructs the ER and Golgi Apparatus and Prevents ErbB2 from Trafficing to the Plasma Membrane T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40025579; 4186726 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Mimnaugh, Edward G AU - Xu, Wanping AU - Vos, Michele AU - Neckers, Len Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Plasma membranes KW - Golgi apparatus KW - SiRNA KW - Valosin-containing protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40025579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Knockdown+of+p97+Valosin-Containing+Protein+by+siRNA+Interference+Deconstructs+the+ER+and+Golgi+Apparatus+and+Prevents+ErbB2+from+Trafficing+to+the+Plasma+Membrane&rft.au=Mimnaugh%2C+Edward+G%3BXu%2C+Wanping%3BVos%2C+Michele%3BNeckers%2C+Len&rft.aulast=Mimnaugh&rft.aufirst=Edward&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Three Novel Splice-Variants of a Tumor Suppressor Candidate, ING4 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40025035; 4186946 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Unoki, Motoko AU - Shen, Jiang Cheng AU - Zhi-Ming, Zheng AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor suppressor genes KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40025035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Three+Novel+Splice-Variants+of+a+Tumor+Suppressor+Candidate%2C+ING4&rft.au=Unoki%2C+Motoko%3BShen%2C+Jiang+Cheng%3BZhi-Ming%2C+Zheng%3BHarris%2C+Curtis+C&rft.aulast=Unoki&rft.aufirst=Motoko&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteasome Inhibitor Bortezomib Augments Tumor Therapy with TRAIL Receptor Agonist Antibody MD5-1 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40020082; 4185827 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Shanker, Anil AU - Brooks, Alan D AU - Tristan, Carlos A AU - Sayers, Thomas J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Antibodies KW - TRAIL protein KW - Proteasome inhibitors KW - Tumors KW - Therapy KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteasome+Inhibitor+Bortezomib+Augments+Tumor+Therapy+with+TRAIL+Receptor+Agonist+Antibody+MD5-1&rft.au=Shanker%2C+Anil%3BBrooks%2C+Alan+D%3BTristan%2C+Carlos+A%3BSayers%2C+Thomas+J&rft.aulast=Shanker&rft.aufirst=Anil&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ezrin, the Cytoskeleton Linker Protein Coordinates Cap-Dependent Translation during Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40020000; 4186076 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Cassavaugh, Jessica AU - Newman, Rachel AU - Ren, Ling AU - Riss, Joseph AU - Wei, Jun AU - Yu, Li-Rong AU - Veenstra, Tim AU - Helman, Lee AU - Khan, Javed AU - Khanna, Chand Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Translation KW - Cytoskeleton KW - Ezrin KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ezrin%2C+the+Cytoskeleton+Linker+Protein+Coordinates+Cap-Dependent+Translation+during+Metastasis&rft.au=Cassavaugh%2C+Jessica%3BNewman%2C+Rachel%3BRen%2C+Ling%3BRiss%2C+Joseph%3BWei%2C+Jun%3BYu%2C+Li-Rong%3BVeenstra%2C+Tim%3BHelman%2C+Lee%3BKhan%2C+Javed%3BKhanna%2C+Chand&rft.aulast=Cassavaugh&rft.aufirst=Jessica&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterozygous Inactivation of Transforming Growth Factor-B1 (TGF-B1) and Mutational Activation of K-Ras Predisposes Early Lung Tumor Progression T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40019463; 4185985 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jakowlew, Sonia B AU - Jacks, Tyler AU - Pandey, Jyotsna Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Transforming growth factor-^b1 KW - K-Ras protein KW - Tumors KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Heterozygous+Inactivation+of+Transforming+Growth+Factor-B1+%28TGF-B1%29+and+Mutational+Activation+of+K-Ras+Predisposes+Early+Lung+Tumor+Progression&rft.au=Jakowlew%2C+Sonia+B%3BJacks%2C+Tyler%3BPandey%2C+Jyotsna&rft.aulast=Jakowlew&rft.aufirst=Sonia&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenic Mouse Models of Liver Cancer Recapitulate the Aberrant Pattern of DNA Methylation in Human Hepatocellular Carcinoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40019408; 4185976 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ladu, Sara AU - Calvisi, Diego F AU - Farina, Miriam AU - Conner, Elizabeth A AU - Sanchez, Aranzazu AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Liver cancer KW - Animal models KW - Hepatocellular carcinoma KW - DNA methylation KW - Transgenic mice KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Transgenic+Mouse+Models+of+Liver+Cancer+Recapitulate+the+Aberrant+Pattern+of+DNA+Methylation+in+Human+Hepatocellular+Carcinoma&rft.au=Ladu%2C+Sara%3BCalvisi%2C+Diego+F%3BFarina%2C+Miriam%3BConner%2C+Elizabeth+A%3BSanchez%2C+Aranzazu%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Ladu&rft.aufirst=Sara&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Magnetic Resonance Techniques for Early and Late Cancer Therapy Trials T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40014668; 4181452 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Choyke, Peter Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - N.M.R. KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40014668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Magnetic+Resonance+Techniques+for+Early+and+Late+Cancer+Therapy+Trials&rft.au=Choyke%2C+Peter&rft.aulast=Choyke&rft.aufirst=Peter&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BDNF/TrkB Pathway Upregulates PTHrP in Neuroblastoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40013826; 4183254 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - McKee, Amy E AU - Martin, Kelly AU - Markovic, Ana AU - Greer, Braden T AU - Wei, Jun S AU - Chen, Qing R AU - Khan, Javed AU - Thiele, Carol J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Parathyroid hormone-related protein KW - Brain-derived neurotrophic factor KW - TrkB receptors KW - Neuroblastoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=BDNF%2FTrkB+Pathway+Upregulates+PTHrP+in+Neuroblastoma&rft.au=McKee%2C+Amy+E%3BMartin%2C+Kelly%3BMarkovic%2C+Ana%3BGreer%2C+Braden+T%3BWei%2C+Jun+S%3BChen%2C+Qing+R%3BKhan%2C+Javed%3BThiele%2C+Carol+J&rft.aulast=McKee&rft.aufirst=Amy&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prospective Study of Aspartame-Containing Beverages and Risk of Hematopoietic and Brain Cancers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40013677; 4183218 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lim, Unhee AU - Subar, Amy F AU - Mouw, Traci AU - Hartge, Patricia AU - Morton, Lindsay M AU - Stolzenberg-Solomon, Rachael AU - Campbell, David S AU - Hollenbeck, Albert R AU - Schatzkin, Arthur Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Brain KW - Cancer KW - Hemopoiesis KW - Beverages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Prospective+Study+of+Aspartame-Containing+Beverages+and+Risk+of+Hematopoietic+and+Brain+Cancers&rft.au=Lim%2C+Unhee%3BSubar%2C+Amy+F%3BMouw%2C+Traci%3BHartge%2C+Patricia%3BMorton%2C+Lindsay+M%3BStolzenberg-Solomon%2C+Rachael%3BCampbell%2C+David+S%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptosis and HCV: An Un-Solved Phenomena T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40013426; 4185479 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zekri, Abdel-Rahman N AU - Bahnassy, Abeer A AU - El-Guendy, Nadia AU - El-Leathy, Heba M AU - Abdel-Wahab, Sabrein A AU - El-Shahaby, Amal M AU - Hafez, Mohamed AU - Radwn, Saher Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Apoptosis KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Apoptosis+and+HCV%3A+An+Un-Solved+Phenomena&rft.au=Zekri%2C+Abdel-Rahman+N%3BBahnassy%2C+Abeer+A%3BEl-Guendy%2C+Nadia%3BEl-Leathy%2C+Heba+M%3BAbdel-Wahab%2C+Sabrein+A%3BEl-Shahaby%2C+Amal+M%3BHafez%2C+Mohamed%3BRadwn%2C+Saher&rft.aulast=Zekri&rft.aufirst=Abdel-Rahman&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms of Genes in the Inflammatory Pathway and the Risk of Gallstones and Biliary Tract Cancer: A Population-Based Study T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40012110; 4187204 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hsing, Ann W AU - Rosenberg, Philip AU - Chen, Bingshu AU - Chen, Jinbo AU - Rashid, Asif AU - Deng, Jie AU - Cohen-Webb, Hope AU - Sakoda, Lori AU - Shen, Ming-Chang AU - Andreotti, Gabriella AU - Wang, Bin-Sheng AU - Han, Tain-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephan AU - Fraumeni Jr, Joseph AU - Gao, Yu-Tang Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Gene polymorphism KW - Population studies KW - Biliary tract KW - Inflammation KW - Biopolymorphism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Polymorphisms+of+Genes+in+the+Inflammatory+Pathway+and+the+Risk+of+Gallstones+and+Biliary+Tract+Cancer%3A+A+Population-Based+Study&rft.au=Hsing%2C+Ann+W%3BRosenberg%2C+Philip%3BChen%2C+Bingshu%3BChen%2C+Jinbo%3BRashid%2C+Asif%3BDeng%2C+Jie%3BCohen-Webb%2C+Hope%3BSakoda%2C+Lori%3BShen%2C+Ming-Chang%3BAndreotti%2C+Gabriella%3BWang%2C+Bin-Sheng%3BHan%2C+Tain-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephan%3BFraumeni+Jr%2C+Joseph%3BGao%2C+Yu-Tang&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Reverse-Phase Protein Microarrays: A Comparison of Trends in Protein Expression Derived from Computerized Linear Regression, Logistic Regression, and Dose Interpolation Models T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40011629; 4183860 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Roque, Dana M AU - Winters, Mary AU - Aquino, Joy AU - Nishizuka, Satoshi AU - Corrado, Chiara AU - Kohn, Elise Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Protein arrays KW - Regression analysis KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40011629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Analysis+of+Reverse-Phase+Protein+Microarrays%3A+A+Comparison+of+Trends+in+Protein+Expression+Derived+from+Computerized+Linear+Regression%2C+Logistic+Regression%2C+and+Dose+Interpolation+Models&rft.au=Roque%2C+Dana+M%3BWinters%2C+Mary%3BAquino%2C+Joy%3BNishizuka%2C+Satoshi%3BCorrado%2C+Chiara%3BKohn%2C+Elise&rft.aulast=Roque&rft.aufirst=Dana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling SLC22 and SLCO Genes in the NCI-60 Cancer Cell Lines to Identify Candidate Substrates T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40011262; 4183773 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Okabe, Mitsunori AU - Szakacs, Gergely AU - Reimers, Mark AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Tumor cell lines KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40011262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Profiling+SLC22+and+SLCO+Genes+in+the+NCI-60+Cancer+Cell+Lines+to+Identify+Candidate+Substrates&rft.au=Okabe%2C+Mitsunori%3BSzakacs%2C+Gergely%3BReimers%2C+Mark%3BGottesman%2C+Michael+M&rft.aulast=Okabe&rft.aufirst=Mitsunori&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of T(14;18)-Positive, Putative Lymphoma Precursor Cells among B Cell Subsets in Healthy Individuals T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009655; 4183956 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hirt, Carsten AU - Doelken, Gottfried AU - Janz, Siegfried AU - Rabkin, Charles S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Lymphocytes B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Distribution+of+T%2814%3B18%29-Positive%2C+Putative+Lymphoma+Precursor+Cells+among+B+Cell+Subsets+in+Healthy+Individuals&rft.au=Hirt%2C+Carsten%3BDoelken%2C+Gottfried%3BJanz%2C+Siegfried%3BRabkin%2C+Charles+S&rft.aulast=Hirt&rft.aufirst=Carsten&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BAG-3 Modulates Cell Phenotype by Inhibiting Adhesion and Altering Gene Expression T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009251; 4186888 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kassis, Jareer N AU - Guancial, Elizabeth A AU - Gius, David AU - Kohn, Elise C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Adhesion KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=BAG-3+Modulates+Cell+Phenotype+by+Inhibiting+Adhesion+and+Altering+Gene+Expression&rft.au=Kassis%2C+Jareer+N%3BGuancial%2C+Elizabeth+A%3BGius%2C+David%3BKohn%2C+Elise+C&rft.aulast=Kassis&rft.aufirst=Jareer&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Myeloid Cells with Suppressive Activity by Human Tumor-Released Microvesicles T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008892; 4184396 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rivoltini, Licia AU - Valenti, Roberta AU - Filipazzi, Paola AU - Huber, Veronica AU - Canese, Paola AU - Pilla, Lorenzo AU - Parmiani, Giorgio Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Myeloid cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+Myeloid+Cells+with+Suppressive+Activity+by+Human+Tumor-Released+Microvesicles&rft.au=Rivoltini%2C+Licia%3BValenti%2C+Roberta%3BFilipazzi%2C+Paola%3BHuber%2C+Veronica%3BCanese%2C+Paola%3BPilla%2C+Lorenzo%3BParmiani%2C+Giorgio&rft.aulast=Rivoltini&rft.aufirst=Licia&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Profiling Distinguishes Astrocytomas of Different Grades and Identifies Differential Tumor Markers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008550; 4186448 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Jie AU - Weil, Robert AU - Okamoto, Hiroaki AU - Vortmeyer, Alexander AU - Lubensky, Irina AU - Park, Deric AU - Furuta, Makoto AU - Lee, Youn-Soo AU - Zeng, Weifen AU - Oldfield, Edward H AU - Zhuang, Zhengping Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor markers KW - Proteomics KW - Astrocytoma KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Profiling+Distinguishes+Astrocytomas+of+Different+Grades+and+Identifies+Differential+Tumor+Markers&rft.au=Li%2C+Jie%3BWeil%2C+Robert%3BOkamoto%2C+Hiroaki%3BVortmeyer%2C+Alexander%3BLubensky%2C+Irina%3BPark%2C+Deric%3BFuruta%2C+Makoto%3BLee%2C+Youn-Soo%3BZeng%2C+Weifen%3BOldfield%2C+Edward+H%3BZhuang%2C+Zhengping&rft.aulast=Li&rft.aufirst=Jie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Loss-Of-Function RNA Interference Screen for Molecular Targets in Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008202; 4184437 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Staudt, Louis M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - RNA-mediated interference UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Loss-Of-Function+RNA+Interference+Screen+for+Molecular+Targets+in+Cancer&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dose-Dependent Degradation of p21CIP1/WAF1 and Mdm2 Precedes Apoptotic Response to Aminoflavone (NSC 686), a Novel Anticancer Agent T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007867; 4187006 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Meng, Ling-Hua AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Waf1 protein KW - Cyclin-dependent kinase inhibitor p21 KW - Antitumor agents KW - Apoptosis KW - MDM2 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Dose-Dependent+Degradation+of+p21CIP1%2FWAF1+and+Mdm2+Precedes+Apoptotic+Response+to+Aminoflavone+%28NSC+686%29%2C+a+Novel+Anticancer+Agent&rft.au=Meng%2C+Ling-Hua%3BPommier%2C+Yves&rft.aulast=Meng&rft.aufirst=Ling-Hua&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in Oxidative Stress Genes and Risk for Non-Hodgkin Lymphoma (NHL) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007820; 4186606 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wang, Sophia S AU - Cerhan, James R AU - Hartge, Patricia AU - Davis, Scott AU - Severson, Richard K AU - Cozen, Wendy AU - Lan, Qing AU - Welch, Robert AU - Chanock, Stephen J AU - Rothman, Nathaniel Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Stress KW - Oxidative stress KW - Gene polymorphism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Polymorphisms+in+Oxidative+Stress+Genes+and+Risk+for+Non-Hodgkin+Lymphoma+%28NHL%29&rft.au=Wang%2C+Sophia+S%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BCozen%2C+Wendy%3BLan%2C+Qing%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Samarium-153 (Quadramet) to Modulate Phenotype and Enhance Killing of Tumor Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007814; 4184336 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wansley, Elizabeth K AU - Chakraborty, Mala AU - Carrasquillo, Jorge AU - Yu, Sarah AU - Paik, Chang AU - Camphausen, Kevin AU - Schlom, Jeffrey AU - Hodge, James Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor cells KW - Tumors KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Use+of+Samarium-153+%28Quadramet%29+to+Modulate+Phenotype+and+Enhance+Killing+of+Tumor+Cells&rft.au=Wansley%2C+Elizabeth+K%3BChakraborty%2C+Mala%3BCarrasquillo%2C+Jorge%3BYu%2C+Sarah%3BPaik%2C+Chang%3BCamphausen%2C+Kevin%3BSchlom%2C+Jeffrey%3BHodge%2C+James&rft.aulast=Wansley&rft.aufirst=Elizabeth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pdcd4: Discovery of Molecular Targets of Cancer Prevention by Aiming at Translation Initiation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40007118; 4184647 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jansen, Aaron P AU - Colburn, Nancy H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prevention KW - Cancer KW - Translation initiation KW - Translation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40007118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Pdcd4%3A+Discovery+of+Molecular+Targets+of+Cancer+Prevention+by+Aiming+at+Translation+Initiation&rft.au=Jansen%2C+Aaron+P%3BColburn%2C+Nancy+H&rft.aulast=Jansen&rft.aufirst=Aaron&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Construction and Validation of Tissue Microarrays of Non-Invasive Structures Associated with Invasive Breast Carcinoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40006862; 4186601 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Xiaohong (Rose) AU - Charette, Lori A AU - Garcia-Closas, Montse AU - Lissowska, Jola AU - Paal, Edina AU - Sidawy, Mary AU - Hewitt, Stephen AU - Rimm, David L AU - Sherman, Mark E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast carcinoma KW - Invasiveness KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Construction+and+Validation+of+Tissue+Microarrays+of+Non-Invasive+Structures+Associated+with+Invasive+Breast+Carcinoma&rft.au=Yang%2C+Xiaohong+%28Rose%29%3BCharette%2C+Lori+A%3BGarcia-Closas%2C+Montse%3BLissowska%2C+Jola%3BPaal%2C+Edina%3BSidawy%2C+Mary%3BHewitt%2C+Stephen%3BRimm%2C+David+L%3BSherman%2C+Mark+E&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Linking Pathway Gene Expressions to the Growth Inhibition Response from the National Cancer Institutes Anticancer Screen and Drug Mechanism of Action T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40005744; 4184580 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Huang, Ruili AU - Wallqvist, Anders AU - Thanki, Narmada AU - Covell, David Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Cancer KW - Gene expression KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Linking+Pathway+Gene+Expressions+to+the+Growth+Inhibition+Response+from+the+National+Cancer+Institutes+Anticancer+Screen+and+Drug+Mechanism+of+Action&rft.au=Huang%2C+Ruili%3BWallqvist%2C+Anders%3BThanki%2C+Narmada%3BCovell%2C+David&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Activity of Aminoflavone (NSC 626288), a Novel Drug in Phase I Clinical Trials is Determined by Cellular Expression of Sulfotransferase T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40005535; 4184529 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Meng, Ling-Hua AU - Shankavaram, Uma AU - Chen, Chi AU - Agama, Keli AU - Gonzalez, Frank AU - Weistein, John AU - Kerrigan, Donna AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Clinical trials KW - Drugs KW - Sulfotransferase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Selective+Activity+of+Aminoflavone+%28NSC+626288%29%2C+a+Novel+Drug+in+Phase+I+Clinical+Trials+is+Determined+by+Cellular+Expression+of+Sulfotransferase&rft.au=Meng%2C+Ling-Hua%3BShankavaram%2C+Uma%3BChen%2C+Chi%3BAgama%2C+Keli%3BGonzalez%2C+Frank%3BWeistein%2C+John%3BKerrigan%2C+Donna%3BPommier%2C+Yves&rft.aulast=Meng&rft.aufirst=Ling-Hua&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ferrous Oxide Microparticle- Enhanced MRI Visualization of Single Metastatic Cells and their Development to Tumors within the Brain: Effects of Anti-Angiogenic Therapy T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40005287; 4187474 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yin, Juan Juan AU - Tracy, Kirsten AU - Munasinghe, Jeeva AU - Shapiro, Erik AU - Koretsky, Alan AU - Kelly, Kathleen Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Brain tumors KW - Magnetic resonance imaging KW - Oxides KW - Metastases KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ferrous+Oxide+Microparticle-+Enhanced+MRI+Visualization+of+Single+Metastatic+Cells+and+their+Development+to+Tumors+within+the+Brain%3A+Effects+of+Anti-Angiogenic+Therapy&rft.au=Yin%2C+Juan+Juan%3BTracy%2C+Kirsten%3BMunasinghe%2C+Jeeva%3BShapiro%2C+Erik%3BKoretsky%2C+Alan%3BKelly%2C+Kathleen&rft.aulast=Yin&rft.aufirst=Juan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phylogenetic Analysis of cis Sequence Effects on Cancer Gene Transcription T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40004563; 4186079 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Bergen, Andrew W AU - Baccarelli, Andrea AU - McDaniel, Timothy K AU - Kuhn, Kenneth AU - Chudin, Eugene AU - Bender, Patrick AU - Pfeiffer, Ruth AU - Packer, Bernice AU - Yeager, Meredith AU - Chanock, Stephen J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Transcription KW - Phylogenetics KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phylogenetic+Analysis+of+cis+Sequence+Effects+on+Cancer+Gene+Transcription&rft.au=Bergen%2C+Andrew+W%3BBaccarelli%2C+Andrea%3BMcDaniel%2C+Timothy+K%3BKuhn%2C+Kenneth%3BChudin%2C+Eugene%3BBender%2C+Patrick%3BPfeiffer%2C+Ruth%3BPacker%2C+Bernice%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J&rft.aulast=Bergen&rft.aufirst=Andrew&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Notch1 Mutations are Acquired in Murine Models of Precursor T-Cell Lymphoblastic Leukemia/Lymphoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40003858; 4184799 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lin, Ying-Wei AU - Nichols, Rebecca A AU - Letterio, John J AU - Aplan, Peter D Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Mutation KW - Lymphatic leukemia KW - Animal models KW - Lymphocytes T UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Notch1+Mutations+are+Acquired+in+Murine+Models+of+Precursor+T-Cell+Lymphoblastic+Leukemia%2FLymphoma&rft.au=Lin%2C+Ying-Wei%3BNichols%2C+Rebecca+A%3BLetterio%2C+John+J%3BAplan%2C+Peter+D&rft.aulast=Lin&rft.aufirst=Ying-Wei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of Extracellular Matrix: Metabolic Augmentation of Angiogenic Signaling by Prolidase T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40003604; 4184764 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Surazynski, Arkadiusz AU - Liu, Yongmin AU - Donald, Steven P AU - Cooper, Sandra AU - Phang, James M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction KW - Prolidase KW - Angiogenesis KW - Extracellular matrix UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Degradation+of+Extracellular+Matrix%3A+Metabolic+Augmentation+of+Angiogenic+Signaling+by+Prolidase&rft.au=Surazynski%2C+Arkadiusz%3BLiu%2C+Yongmin%3BDonald%2C+Steven+P%3BCooper%2C+Sandra%3BPhang%2C+James+M&rft.aulast=Surazynski&rft.aufirst=Arkadiusz&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MMP-Independent Mechanism of TIMP-2 to Regulate Tumor Growth and Angiogenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40003433; 4184746 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Hongmei AU - Diaz, Terry AU - Wei, Beiyang AU - Stetler-Stevenson, William G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tissue inhibitor of metalloproteinase 2 KW - Angiogenesis KW - Tumors KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=MMP-Independent+Mechanism+of+TIMP-2+to+Regulate+Tumor+Growth+and+Angiogenesis&rft.au=Li%2C+Hongmei%3BDiaz%2C+Terry%3BWei%2C+Beiyang%3BStetler-Stevenson%2C+William+G&rft.aulast=Li&rft.aufirst=Hongmei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conserved Genetic Networks Define ER-Alpha Status and Luminal and Basal Phenotypes in Mouse and Human Mammary Cancer: Added Value from the Mouse T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002823; 4184977 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Michalowska, Aleksandra M AU - Qiu, Ting-Hu AU - Kavanaugh, Claudine AU - Lee, Eva Y.-H.P. AU - Medina, Daniel AU - Xu, Xiaoling AU - Deng, Chu-Xia AU - Powell, John I AU - Shih, Joanna H AU - Green, Jeffrey E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Conserved+Genetic+Networks+Define+ER-Alpha+Status+and+Luminal+and+Basal+Phenotypes+in+Mouse+and+Human+Mammary+Cancer%3A+Added+Value+from+the+Mouse&rft.au=Michalowska%2C+Aleksandra+M%3BQiu%2C+Ting-Hu%3BKavanaugh%2C+Claudine%3BLee%2C+Eva+Y.-H.P.%3BMedina%2C+Daniel%3BXu%2C+Xiaoling%3BDeng%2C+Chu-Xia%3BPowell%2C+John+I%3BShih%2C+Joanna+H%3BGreen%2C+Jeffrey+E&rft.aulast=Michalowska&rft.aufirst=Aleksandra&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Identification of Novel miRNAs within the Non-Coding PVT1 Transcript may be Associated with Regulation of MYC T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002659; 4186077 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Huppi, Konrad AU - Volfovsky, Natalia AU - Runfola, Timothy AU - Stephens, Robert AU - Thomas, Cheryl AU - Lader, Eric AU - Mushinski, J Frederic AU - Caplen, Natasha J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - MiRNA KW - Transcription KW - Myc protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Identification+of+Novel+miRNAs+within+the+Non-Coding+PVT1+Transcript+may+be+Associated+with+Regulation+of+MYC&rft.au=Huppi%2C+Konrad%3BVolfovsky%2C+Natalia%3BRunfola%2C+Timothy%3BStephens%2C+Robert%3BThomas%2C+Cheryl%3BLader%2C+Eric%3BMushinski%2C+J+Frederic%3BCaplen%2C+Natasha+J&rft.aulast=Huppi&rft.aufirst=Konrad&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A SNP in the FLT1 Promoter Integrates the VEGF System Into the p53 Master Regulatory Network and Leads to Synergistic Transcriptional Responses to Environmental Stresses Via p53 and Estrogen Receptor T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002568; 4185093 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Menendez, Daniel AU - Inga, Alberto AU - Snipe, Joyce AU - Krysiak, Oliver AU - Schonfelder, Gilbert AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Environmental stress KW - Estrogen receptors KW - P53 protein KW - Promoters KW - Transcription KW - Single-nucleotide polymorphism KW - Vascular endothelial growth factor KW - Sex hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+SNP+in+the+FLT1+Promoter+Integrates+the+VEGF+System+Into+the+p53+Master+Regulatory+Network+and+Leads+to+Synergistic+Transcriptional+Responses+to+Environmental+Stresses+Via+p53+and+Estrogen+Receptor&rft.au=Menendez%2C+Daniel%3BInga%2C+Alberto%3BSnipe%2C+Joyce%3BKrysiak%2C+Oliver%3BSchonfelder%2C+Gilbert%3BResnick%2C+Michael+A&rft.aulast=Menendez&rft.aufirst=Daniel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Functional Polymorphisms in Transcription Factor Binding Sites in Human Genome by Association of Genotype-Expression Phenotype T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002100; 4184978 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wang, Xuting AU - Chorley, Brian N AU - Cheung, Vivian G AU - Kleeberger, Steven R AU - Bell, Douglas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Genomes KW - Gene polymorphism KW - Transcription factors KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Functional+Polymorphisms+in+Transcription+Factor+Binding+Sites+in+Human+Genome+by+Association+of+Genotype-Expression+Phenotype&rft.au=Wang%2C+Xuting%3BChorley%2C+Brian+N%3BCheung%2C+Vivian+G%3BKleeberger%2C+Steven+R%3BBell%2C+Douglas+A&rft.aulast=Wang&rft.aufirst=Xuting&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphoproteomic Profiling of the Epithelial and Stromal Components of Matched Normal and Colonic Carcinomas Using Protein Microarrays Reveals Novel Insights into Functional Pathway Derangements T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000986; 4182677 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sheehan, Katherine M AU - Gulmann, Christian AU - Eichler, Gabriel S AU - Barrett, Helen L AU - Kay, Elaine W AU - Liotta, Lance A AU - Petricoin III, Emanuel F. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Protein arrays KW - Carcinoma KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phosphoproteomic+Profiling+of+the+Epithelial+and+Stromal+Components+of+Matched+Normal+and+Colonic+Carcinomas+Using+Protein+Microarrays+Reveals+Novel+Insights+into+Functional+Pathway+Derangements&rft.au=Sheehan%2C+Katherine+M%3BGulmann%2C+Christian%3BEichler%2C+Gabriel+S%3BBarrett%2C+Helen+L%3BKay%2C+Elaine+W%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Sheehan&rft.aufirst=Katherine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Intrinsic and Tissue-Specific Oncogenic Pathways Induced by Simian Virus 40 T/t-Antigens: A Network Systems Analysis of Expression Profiles of Mouse Models of Human Cancers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000897; 4182289 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kee, Kristin AU - Michalowska, Aleksandra M AU - Yoon, Cheol-yong AU - Krummey, Scott M AU - Johnson, Mac A AU - Greenberg, Norman M AU - Linnoila, Ilona AU - Green, Jeffrey E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Systems analysis KW - Cancer KW - Animal models KW - Simian virus 40 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Intrinsic+and+Tissue-Specific+Oncogenic+Pathways+Induced+by+Simian+Virus+40+T%2Ft-Antigens%3A+A+Network+Systems+Analysis+of+Expression+Profiles+of+Mouse+Models+of+Human+Cancers&rft.au=Kee%2C+Kristin%3BMichalowska%2C+Aleksandra+M%3BYoon%2C+Cheol-yong%3BKrummey%2C+Scott+M%3BJohnson%2C+Mac+A%3BGreenberg%2C+Norman+M%3BLinnoila%2C+Ilona%3BGreen%2C+Jeffrey+E&rft.aulast=Kee&rft.aufirst=Kristin&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Gene Signature that can Predict Survival in Suboptimally Debulked Patients with High-Grade Late-Stage Serous Ovarian Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39999093; 4182451 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Bonome, Tomas AU - Levine, Douglas A AU - Shih, Joanna AU - Brady, John AU - Randonovich, Mike AU - Pise-Masison, Cindy AU - Boyd, Jeff AU - Birrer, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39999093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+a+Gene+Signature+that+can+Predict+Survival+in+Suboptimally+Debulked+Patients+with+High-Grade+Late-Stage+Serous+Ovarian+Cancer&rft.au=Bonome%2C+Tomas%3BLevine%2C+Douglas+A%3BShih%2C+Joanna%3BBrady%2C+John%3BRandonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBoyd%2C+Jeff%3BBirrer%2C+Michael+J&rft.aulast=Bonome&rft.aufirst=Tomas&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Molecular Profiling of the NCI-60 Cancer Cell Panel: A Human Cancer Cell Line Integromics Project (HCLIP) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39998736; 4181627 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Weinstein, John N AU - Kane, David W AU - Zeeberg, Barry R AU - Reimers, Mark AU - Nishizuka, Satoshi AU - Shankavaram, Uma AU - Bussey, Kimberly J AU - Lorenzi, Philip AU - Ikediobi, Ogechi AU - Kohn, Kurt W AU - Aladjem, Mirit AU - Pommier, Yves AU - Scudiero, Dominic AU - Holbeck, Susan AU - Reinhold, William C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Tumor cell lines KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Comprehensive+Molecular+Profiling+of+the+NCI-60+Cancer+Cell+Panel%3A+A+Human+Cancer+Cell+Line+Integromics+Project+%28HCLIP%29&rft.au=Weinstein%2C+John+N%3BKane%2C+David+W%3BZeeberg%2C+Barry+R%3BReimers%2C+Mark%3BNishizuka%2C+Satoshi%3BShankavaram%2C+Uma%3BBussey%2C+Kimberly+J%3BLorenzi%2C+Philip%3BIkediobi%2C+Ogechi%3BKohn%2C+Kurt+W%3BAladjem%2C+Mirit%3BPommier%2C+Yves%3BScudiero%2C+Dominic%3BHolbeck%2C+Susan%3BReinhold%2C+William+C&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen/ER Signaling Plays an Active Role in the Early Stages of BRCA1-Associated Mammary Tumor Formation in Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39997933; 4182750 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Wenmei AU - Deng, Chuxia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Estrogen receptors KW - Mammary gland KW - Signal transduction KW - Tumors KW - Sex hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39997933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Estrogen%2FER+Signaling+Plays+an+Active+Role+in+the+Early+Stages+of+BRCA1-Associated+Mammary+Tumor+Formation+in+Mice&rft.au=Li%2C+Wenmei%3BDeng%2C+Chuxia&rft.aulast=Li&rft.aufirst=Wenmei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclooxygenase-2 Inhibits UVB-Induced Skin Damage and Apoptosis in Mouse Skin Through Stimulation of EP2 and EP4 Receptor Signaling Pathways T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39997179; 4181835 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chun, Kyung-Soo AU - Langenbach, Robert Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Skin KW - Signal transduction KW - Apoptosis KW - Cyclooxygenase-2 KW - Environmental effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39997179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cyclooxygenase-2+Inhibits+UVB-Induced+Skin+Damage+and+Apoptosis+in+Mouse+Skin+Through+Stimulation+of+EP2+and+EP4+Receptor+Signaling+Pathways&rft.au=Chun%2C+Kyung-Soo%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aberrant DNA Double-Strand Break Repair in the ovarian Cancer Cell Line OVCAR-8 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39994995; 4183544 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Cheng, Yue AU - Varga, Tamas AU - Aplan, Peter Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Tumor cell lines KW - DNA damage KW - Double-strand break repair KW - DNA repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Aberrant+DNA+Double-Strand+Break+Repair+in+the+ovarian+Cancer+Cell+Line+OVCAR-8&rft.au=Cheng%2C+Yue%3BVarga%2C+Tamas%3BAplan%2C+Peter&rft.aulast=Cheng&rft.aufirst=Yue&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Staurosporine Induced CAIR-1/BAG-3 Degradation is Mediated by Caspases and the Proteasome T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39994573; 4183523 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Virador, Victoria M AU - Davidson, Ben AU - Czechowicz, Josephine AU - Kohn, Elise Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Caspase KW - Proteasomes KW - Staurosporine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39994573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Staurosporine+Induced+CAIR-1%2FBAG-3+Degradation+is+Mediated+by+Caspases+and+the+Proteasome&rft.au=Virador%2C+Victoria+M%3BDavidson%2C+Ben%3BCzechowicz%2C+Josephine%3BKohn%2C+Elise&rft.aulast=Virador&rft.aufirst=Victoria&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphorylation of the Blooms Syndrome Protein (BLM) and Co-Assembly with Checkpoint Response Proteins After Topoisomerase I-Induced Replication Damage by Camptothecin T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39991846; 4181996 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rao, V Ashutosh AU - Hickson, Ian AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Camptothecin KW - Replication KW - Bloom's syndrome KW - Phosphorylation KW - Phytoplankton KW - Symptoms KW - Algal blooms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phosphorylation+of+the+Blooms+Syndrome+Protein+%28BLM%29+and+Co-Assembly+with+Checkpoint+Response+Proteins+After+Topoisomerase+I-Induced+Replication+Damage+by+Camptothecin&rft.au=Rao%2C+V+Ashutosh%3BHickson%2C+Ian%3BPommier%2C+Yves&rft.aulast=Rao&rft.aufirst=V&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PI3K/Akt Signaling Pathway Regulates c-Myc via NFkB and GSK3b in Mouse iMyc-Em B Lymphoma Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39991699; 4182976 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, Ki-Hwan AU - Davis, R Eric AU - Chung, Seung-Tae AU - Janz, Siegfried Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Signal transduction KW - 1-Phosphatidylinositol 3-kinase KW - C-Myc protein KW - NF-^KB protein KW - B-cell lymphoma KW - AKT protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=PI3K%2FAkt+Signaling+Pathway+Regulates+c-Myc+via+NFkB+and+GSK3b+in+Mouse+iMyc-Em+B+Lymphoma+Cells&rft.au=Kim%2C+Ki-Hwan%3BDavis%2C+R+Eric%3BChung%2C+Seung-Tae%3BJanz%2C+Siegfried&rft.aulast=Kim&rft.aufirst=Ki-Hwan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of HGF/C-Met Signaling Pathway Accelerates Early Stages of DEN-Induced Hepatocarcinogenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39991136; 4181812 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Takami, Taro AU - Uchida, Kiochi AU - xKaposi-Novak, Kiochi AU - Conner, Elizabeth A AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Loss+of+HGF%2FC-Met+Signaling+Pathway+Accelerates+Early+Stages+of+DEN-Induced+Hepatocarcinogenesis&rft.au=Takami%2C+Taro%3BUchida%2C+Kiochi%3BxKaposi-Novak%2C+Kiochi%3BConner%2C+Elizabeth+A%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Takami&rft.aufirst=Taro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ionizing Radiation Induces Mast Cell Degranulation and May Contribute to Fibrosis in Patients Undergoing Radiation Therapy T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39988833; 4181973 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Simone, Nicole L AU - Soule, Benjamin P AU - Brown, Jared AU - Metcalf, Dean AU - Mitchell, James M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Radiation therapy KW - Ionizing radiation KW - Mast cells KW - Fibrosis KW - Degranulation KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39988833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ionizing+Radiation+Induces+Mast+Cell+Degranulation+and+May+Contribute+to+Fibrosis+in+Patients+Undergoing+Radiation+Therapy&rft.au=Simone%2C+Nicole+L%3BSoule%2C+Benjamin+P%3BBrown%2C+Jared%3BMetcalf%2C+Dean%3BMitchell%2C+James+M&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Assessment of New Cancer Tests: Path to the Clinic T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39985915; 4186722 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lively, Tracy G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Assessment+of+New+Cancer+Tests%3A+Path+to+the+Clinic&rft.au=Lively%2C+Tracy+G&rft.aulast=Lively&rft.aufirst=Tracy&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The AKT/mTor Pathway as a Target for Chemoprevention T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39981455; 4181426 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dennis, Phillip A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - AKT protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39981455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+AKT%2FmTor+Pathway+as+a+Target+for+Chemoprevention&rft.au=Dennis%2C+Phillip+A&rft.aulast=Dennis&rft.aufirst=Phillip&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromogenic in Situ Hybridization (CISH) for X- And Y-Chromosomes in Sex Determination of Anatomic Pathology Specimens T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973504; 4183827 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Silva, Aloisio S AU - Palau, Mauricio AU - Merino, Maria J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pathology KW - Sex determination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chromogenic+in+Situ+Hybridization+%28CISH%29+for+X-+And+Y-Chromosomes+in+Sex+Determination+of+Anatomic+Pathology+Specimens&rft.au=Silva%2C+Aloisio+S%3BPalau%2C+Mauricio%3BMerino%2C+Maria+J&rft.aulast=Silva&rft.aufirst=Aloisio&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ecteinascidin-Induced DNA Double Strand Breaks: A Link between Histone Gamma-H2AX, Transcription-Coupled Nucleotide Excision Repair and Mre11 Endonuclease T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39972581; 4184040 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Guirouilh-Barbat, Josee AU - Sedelnikova, Olga A AU - Bonner, William M AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Histones KW - Transcription KW - DNA damage KW - Endonuclease KW - Nucleotide excision repair KW - Nucleotides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39972581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ecteinascidin-Induced+DNA+Double+Strand+Breaks%3A+A+Link+between+Histone+Gamma-H2AX%2C+Transcription-Coupled+Nucleotide+Excision+Repair+and+Mre11+Endonuclease&rft.au=Guirouilh-Barbat%2C+Josee%3BSedelnikova%2C+Olga+A%3BBonner%2C+William+M%3BPommier%2C+Yves&rft.aulast=Guirouilh-Barbat&rft.aufirst=Josee&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Analysis of Control and Nm23-H1 Overexpressing Breast Carcinoma Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39972557; 4184823 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lee, Jong Heun AU - Horak, Christine E AU - Elkahoun, Abdel AU - Conrads, Thomas P AU - Palmieri, Diane AU - Halverson, Douglas O AU - Meltzer, Paul AU - Veenstra, Timothy D AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast carcinoma KW - Proteomics KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39972557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Analysis+of+Control+and+Nm23-H1+Overexpressing+Breast+Carcinoma+Cells&rft.au=Lee%2C+Jong+Heun%3BHorak%2C+Christine+E%3BElkahoun%2C+Abdel%3BConrads%2C+Thomas+P%3BPalmieri%2C+Diane%3BHalverson%2C+Douglas+O%3BMeltzer%2C+Paul%3BVeenstra%2C+Timothy+D%3BSteeg%2C+Patricia+S&rft.aulast=Lee&rft.aufirst=Jong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Haplotypes of IL8RB and Survival of Patients with B-Cell Lymphoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39972127; 4183954 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Brown, Elizabeth E AU - Domingo-Domenech, Eva AU - Benavente, Yolanda AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Wang, Sophia AU - Yeager, Meredith AU - Lan, Qing AU - Whitby, Denise AU - Desanjose, Silvia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - B-cell lymphoma KW - Survival KW - Haplotypes KW - Cell survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39972127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Haplotypes+of+IL8RB+and+Survival+of+Patients+with+B-Cell+Lymphoma&rft.au=Brown%2C+Elizabeth+E%3BDomingo-Domenech%2C+Eva%3BBenavente%2C+Yolanda%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BWang%2C+Sophia%3BYeager%2C+Meredith%3BLan%2C+Qing%3BWhitby%2C+Denise%3BDesanjose%2C+Silvia&rft.aulast=Brown&rft.aufirst=Elizabeth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain-Derived Neurotrophic Factor Activation of TrkB Induces VEGF Expression via HIF-1a in Neuroblastoma Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39971514; 4186511 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Nakamura, Katsuya AU - Jackson, Jennifer K AU - Martin, Kelly C AU - Kiichiro, Beppu AU - Woo, Chan-Wook AU - Thiele, Carol J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hypoxia-inducible factor 1a KW - Neuroblastoma cells KW - Brain-derived neurotrophic factor KW - TrkB receptors KW - Vascular endothelial growth factor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Brain-Derived+Neurotrophic+Factor+Activation+of+TrkB+Induces+VEGF+Expression+via+HIF-1a+in+Neuroblastoma+Cells&rft.au=Nakamura%2C+Katsuya%3BJackson%2C+Jennifer+K%3BMartin%2C+Kelly+C%3BKiichiro%2C+Beppu%3BWoo%2C+Chan-Wook%3BThiele%2C+Carol+J&rft.aulast=Nakamura&rft.aufirst=Katsuya&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cytotoxic T-Lymphocyte Epitope(s) and its Agonist Epitope(s) of a Novel Target for Vaccine Therapy T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39970947; 4186375 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yokokawa, Junko AU - Bera, Tapan K AU - Palena, Claudia AU - Poole, Diane J AU - Arlen, Philip AU - Gulley, James AU - Pastan, Ira AU - Schlom, Jeffrey AU - Tsang, Kwong Y Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Cytotoxicity KW - Lymphocytes T KW - Therapy KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39970947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Cytotoxic+T-Lymphocyte+Epitope%28s%29+and+its+Agonist+Epitope%28s%29+of+a+Novel+Target+for+Vaccine+Therapy&rft.au=Yokokawa%2C+Junko%3BBera%2C+Tapan+K%3BPalena%2C+Claudia%3BPoole%2C+Diane+J%3BArlen%2C+Philip%3BGulley%2C+James%3BPastan%2C+Ira%3BSchlom%2C+Jeffrey%3BTsang%2C+Kwong+Y&rft.aulast=Yokokawa&rft.aufirst=Junko&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ubiquitin Mediated Down-Regulation of Receptor Tyrosine Kinases and Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39970904; 4181462 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lipkowitz, Stanley Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Ubiquitin KW - Protein-tyrosine kinase receptors KW - Tyrosine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39970904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ubiquitin+Mediated+Down-Regulation+of+Receptor+Tyrosine+Kinases+and+Cancer&rft.au=Lipkowitz%2C+Stanley&rft.aulast=Lipkowitz&rft.aufirst=Stanley&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asparagine Synthetase as a Biomarker for L-Asparaginase Activity in Ovarian Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39970854; 4187330 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lorenzi, Philip L AU - Thomas, Cheryl L AU - Gunsior, Michele AU - Goldsmith, Paul K AU - Bussey, Kimberly J AU - Raffeld, Mark AU - Scherf, Uwe AU - Reinhold, William C AU - Martin, Scott E AU - Rudelius, Martina AU - Von Hoff, Daniel D AU - Caplen, Natasha J AU - Weinstein, John N Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bioindicators KW - Ovarian cancer KW - L-asparaginase KW - Aspartate-ammonia ligase KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39970854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Asparagine+Synthetase+as+a+Biomarker+for+L-Asparaginase+Activity+in+Ovarian+Cancer&rft.au=Lorenzi%2C+Philip+L%3BThomas%2C+Cheryl+L%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul+K%3BBussey%2C+Kimberly+J%3BRaffeld%2C+Mark%3BScherf%2C+Uwe%3BReinhold%2C+William+C%3BMartin%2C+Scott+E%3BRudelius%2C+Martina%3BVon+Hoff%2C+Daniel+D%3BCaplen%2C+Natasha+J%3BWeinstein%2C+John+N&rft.aulast=Lorenzi&rft.aufirst=Philip&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Enhancement of Tumor Vaccine by Blockade of TGF-b T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39970186; 4183203 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Terabe, Masaki AU - Ambrosino, Elana AU - Takaku, Shun AU - Peng, Judy AU - Berzofsky, Jay A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Cancer vaccines KW - Transforming growth factor-^b KW - Tumors KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39970186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Synergistic+Enhancement+of+Tumor+Vaccine+by+Blockade+of+TGF-b&rft.au=Terabe%2C+Masaki%3BAmbrosino%2C+Elana%3BTakaku%2C+Shun%3BPeng%2C+Judy%3BBerzofsky%2C+Jay+A&rft.aulast=Terabe&rft.aufirst=Masaki&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imprinted Adaptor Protein Grb10 Interacts Genetically with Nf1/p53 in Development and Tumorigenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969837; 4187461 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reilly, Karlyne M AU - Tuskan, Robert AU - Kumar, Krishan AU - Stewart, Colin AU - Hagan, John AU - Fox, Kristi Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumorigenesis KW - P53 protein KW - Adaptor proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Imprinted+Adaptor+Protein+Grb10+Interacts+Genetically+with+Nf1%2Fp53+in+Development+and+Tumorigenesis&rft.au=Reilly%2C+Karlyne+M%3BTuskan%2C+Robert%3BKumar%2C+Krishan%3BStewart%2C+Colin%3BHagan%2C+John%3BFox%2C+Kristi&rft.aulast=Reilly&rft.aufirst=Karlyne&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Permanently Altered Uterine Gene Expression in CD-1 Mice Following Developmental Treatment with Diethylstilbestrol (DES): Potential Mechanisms Involved in Transmission of Cancer to Subsequent Generations T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969542; 4187061 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Newbold, Retha R AU - Grissom, Sherry F AU - Padilla-Banks, Elizabeth AU - Snyder, Ryan J AU - Lobenhofer, Edward K AU - Jefferson, Wendy N Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Uterine cancer KW - Gene expression KW - Uterus KW - Diethylstilbestrol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Permanently+Altered+Uterine+Gene+Expression+in+CD-1+Mice+Following+Developmental+Treatment+with+Diethylstilbestrol+%28DES%29%3A+Potential+Mechanisms+Involved+in+Transmission+of+Cancer+to+Subsequent+Generations&rft.au=Newbold%2C+Retha+R%3BGrissom%2C+Sherry+F%3BPadilla-Banks%2C+Elizabeth%3BSnyder%2C+Ryan+J%3BLobenhofer%2C+Edward+K%3BJefferson%2C+Wendy+N&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Variation Patterns as Indicators of Functional Changes in Breast Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969351; 4182313 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reimers, Mark AU - Boersma, Brenda AU - Weinstein, John N AU - Ambs, Stefan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Gene+Expression+Variation+Patterns+as+Indicators+of+Functional+Changes+in+Breast+Cancer&rft.au=Reimers%2C+Mark%3BBoersma%2C+Brenda%3BWeinstein%2C+John+N%3BAmbs%2C+Stefan&rft.aulast=Reimers&rft.aufirst=Mark&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting the Oncogenic Consequences of p19Arf/p53- and p16Ink4a/pRB-Pathway Disruption T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969123; 4186958 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ichikawa, Takeshi AU - Sviderskaya, Elena AU - Ha, Linan AU - Anver, Miriam AU - Sharpless, Norman E AU - DePinho, Ronald A AU - Bennett, Dorothy C AU - Merlino, Glenn Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - INK4a protein KW - P16 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Dissecting+the+Oncogenic+Consequences+of+p19Arf%2Fp53-+and+p16Ink4a%2FpRB-Pathway+Disruption&rft.au=Ichikawa%2C+Takeshi%3BSviderskaya%2C+Elena%3BHa%2C+Linan%3BAnver%2C+Miriam%3BSharpless%2C+Norman+E%3BDePinho%2C+Ronald+A%3BBennett%2C+Dorothy+C%3BMerlino%2C+Glenn&rft.aulast=Ichikawa&rft.aufirst=Takeshi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Pattern of MAP3K8 and MMP9 in Lung Cancer Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969073; 4186941 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pandey, Jyotsna AU - Dempsey, Jamie AU - Clark, Adam AU - Brooks, John AU - Wiest, Jonathan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Tumor cell lines KW - Gelatinase B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Expression+Pattern+of+MAP3K8+and+MMP9+in+Lung+Cancer+Cell+Lines&rft.au=Pandey%2C+Jyotsna%3BDempsey%2C+Jamie%3BClark%2C+Adam%3BBrooks%2C+John%3BWiest%2C+Jonathan&rft.aulast=Pandey&rft.aufirst=Jyotsna&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Growth of Alveolar Soft Part Sarcoma (ASPS) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968853; 4182169 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Vistica, David T AU - Kenney, Susan AU - Borgel, Suzanne D AU - Hollingshead, Melinda G AU - Wallqvist, Anders S AU - Covell, David G AU - Schrump, David S AU - Zhao, Ming AU - Krosky, Paula M AU - Stockwin, Luke H AU - Butcher, Donna O AU - Scudiero, Dominic A AU - Shoemaker, Robert H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Sarcoma KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Zenapax+Therapy+for+Uveitis&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGFa and TGFb 1 Contrarily Effect Alveolar Survival and Tumorigenesis in Mouse Mammary Epithelium T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968609; 4186412 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Booth, Brian W AU - Jhappan, Chamelli AU - Merlino, Glenn AU - Smith, Gilbert H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumorigenesis KW - Survival KW - Transforming growth factor-^b KW - Epithelium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=TGFa+and+TGFb+1+Contrarily+Effect+Alveolar+Survival+and+Tumorigenesis+in+Mouse+Mammary+Epithelium&rft.au=Booth%2C+Brian+W%3BJhappan%2C+Chamelli%3BMerlino%2C+Glenn%3BSmith%2C+Gilbert+H&rft.aulast=Booth&rft.aufirst=Brian&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-Time In Vivo Proteomic Cell Signaling Profiles of Human Tumor Responses to Regional Perfusion Chemotherapy Identifies Phosphorylation Changes in Akt and mTor that Correlate with Clinical Outcome T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968517; 4182687 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Calvo, Katherine R AU - Mundinger, Gerhard S AU - Marks, Clifford AU - Winters, Mary AU - Espina, Virginia AU - Petricoin III, Emanuel F. 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4185883 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Antony, Smitha AU - Agama, Keli A AU - Nagarajan, Muthukaman AU - Cushman, Mark AU - Bonner, William M AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bioindicators KW - Histones KW - DNA topoisomerase KW - Biomarkers KW - Pharmacodynamics KW - Pharmacology KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Histone+U-H2AX+as+a+Pharmacodynamic+Biomarker+for+the+Indenoisoquinoline+Topoisomerase+I+Inhibitors+Selected+for+Preclinical+Development&rft.au=Antony%2C+Smitha%3BAgama%2C+Keli+A%3BNagarajan%2C+Muthukaman%3BCushman%2C+Mark%3BBonner%2C+William+M%3BPommier%2C+Yves&rft.aulast=Antony&rft.aufirst=Smitha&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Formation via Loss of a Chromatin-Associated Molecular Motor.Protein T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968039; 4182507 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Mazumdar, Manjari AU - Lee, Ji-Hyeon AU - Sengupta, Kundan AU - Ried, Thomas AU - Rane, Sushil AU - Misteli, Tom Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Tumor+Formation+via+Loss+of+a+Chromatin-Associated+Molecular+Motor.Protein&rft.au=Mazumdar%2C+Manjari%3BLee%2C+Ji-Hyeon%3BSengupta%2C+Kundan%3BRied%2C+Thomas%3BRane%2C+Sushil%3BMisteli%2C+Tom&rft.aulast=Mazumdar&rft.aufirst=Manjari&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacologic Inhibition of the Mitogen-Activated Protein Kinase/Extracellular Signal Regulated Kinase (MEK) Pathway not Only Results in Inhibition of Cell Proliferation but Also Profound Suppression of IL1- or EGF-Induced Production of Pro-Angiogenesis Cytokines in Cultured Thoracic Cancer Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967924; 4185314 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sehgal, Shailen AU - Nguyen, Duc M AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Zuo, JingTong AU - Schrump, David S AU - Nguyen, Dao M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Cell proliferation KW - Interleukin 1 KW - MAP kinase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Pharmacologic+Inhibition+of+the+Mitogen-Activated+Protein+Kinase%2FExtracellular+Signal+Regulated+Kinase+%28MEK%29+Pathway+not+Only+Results+in+Inhibition+of+Cell+Proliferation+but+Also+Profound+Suppression+of+IL1-+or+EGF-Induced+Production+of+Pro-Angiogenesis+Cytokines+in+Cultured+Thoracic+Cancer+Cells&rft.au=Sehgal%2C+Shailen%3BNguyen%2C+Duc+M%3BYeow%2C+Wen-Shuz%3BChua%2C+Alex%3BZuo%2C+JingTong%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Sehgal&rft.aufirst=Shailen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p53 Transactivation from Response Element Sequences within Cells may not Reflect In Vitro DNA Binding Ability T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966840; 4183199 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jordan, Jennifer J AU - Inga, Alberto AU - Darden, Thomas A AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Regulatory sequences KW - P53 protein KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=p53+Transactivation+from+Response+Element+Sequences+within+Cells+may+not+Reflect+In+Vitro+DNA+Binding+Ability&rft.au=Jordan%2C+Jennifer+J%3BInga%2C+Alberto%3BDarden%2C+Thomas+A%3BResnick%2C+Michael+A&rft.aulast=Jordan&rft.aufirst=Jennifer&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Acquired Resistance to Iodonium-Class Nadph Oxidase Inhibitors in Human Colorectal Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966252; 4184027 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Doroshow, James H AU - Strong, Edward AU - Dulack, Austin AU - Wood, Amanda AU - Eagleton, Jessie AU - Lwin, Waymee AU - Roy, Krishnendu Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Colorectal cancer KW - NADPH oxidase KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mechanisms+of+Acquired+Resistance+to+Iodonium-Class+Nadph+Oxidase+Inhibitors+in+Human+Colorectal+Cancer&rft.au=Doroshow%2C+James+H%3BStrong%2C+Edward%3BDulack%2C+Austin%3BWood%2C+Amanda%3BEagleton%2C+Jessie%3BLwin%2C+Waymee%3BRoy%2C+Krishnendu&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Novel Therapeutic Strategies for Lung Cancer: Targeting the Cholinergic System T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966216; 4184016 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Russo, Patrizia A AU - Sessa, Fausto AU - Catassi, Alessia AU - Viaggi, Silvia AU - Cilli, Michele AU - Ognio, Emanuela AU - Doria-Miglietta, Guido AU - Paolucci, Massimo AU - Calcaterra, Andrea AU - Pericelli, Andrea AU - Fini, Massimo AU - Cesario, Alfredo AU - Granone, Pierluigi AU - Servent, Denis AU - Dominioni, Lorenzo Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Development+of+Novel+Therapeutic+Strategies+for+Lung+Cancer%3A+Targeting+the+Cholinergic+System&rft.au=Russo%2C+Patrizia+A%3BSessa%2C+Fausto%3BCatassi%2C+Alessia%3BViaggi%2C+Silvia%3BCilli%2C+Michele%3BOgnio%2C+Emanuela%3BDoria-Miglietta%2C+Guido%3BPaolucci%2C+Massimo%3BCalcaterra%2C+Andrea%3BPericelli%2C+Andrea%3BFini%2C+Massimo%3BCesario%2C+Alfredo%3BGranone%2C+Pierluigi%3BServent%2C+Denis%3BDominioni%2C+Lorenzo&rft.aulast=Russo&rft.aufirst=Patrizia&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational Identification of p53 Response Elements: Evaluating the (f)Utility of Comparative Genomics Approaches T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966009; 4184976 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Horvath, Monica M AU - Tomso, Daniel J AU - Resnick, Michael A AU - Bell, Douglas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Regulatory sequences KW - P53 protein KW - Genomics KW - Computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Computational+Identification+of+p53+Response+Elements%3A+Evaluating+the+%28f%29Utility+of+Comparative+Genomics+Approaches&rft.au=Horvath%2C+Monica+M%3BTomso%2C+Daniel+J%3BResnick%2C+Michael+A%3BBell%2C+Douglas+A&rft.aulast=Horvath&rft.aufirst=Monica&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Contribution of Her-2 to Breast Cancer Brain Metastases T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39965601; 4184477 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Bronder, Julie L AU - Palmieri, Diane AU - Yoneda, Toshiyuki AU - Weil, Robert J AU - Stark, Andreas M AU - Mehdorn, H Maximilian AU - Davis, Sean AU - Walker, Robert AU - Meltzer, Paul S AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Brain KW - Breast cancer KW - HER2 protein KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39965601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Contribution+of+Her-2+to+Breast+Cancer+Brain+Metastases&rft.au=Bronder%2C+Julie+L%3BPalmieri%2C+Diane%3BYoneda%2C+Toshiyuki%3BWeil%2C+Robert+J%3BStark%2C+Andreas+M%3BMehdorn%2C+H+Maximilian%3BDavis%2C+Sean%3BWalker%2C+Robert%3BMeltzer%2C+Paul+S%3BSteeg%2C+Patricia+S&rft.aulast=Bronder&rft.aufirst=Julie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating the Role of Evil, a Drosophila Melanogaster Homologue of Human BAG-Family Proteins, in Apoptosis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964563; 4183357 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Mai, Shu-Fen AU - Frueauf, Jeremiah B AU - Aderson, Ellen M AU - Vrailas, Alysia D AU - Davidson, Florence AU - Kohn, Elise C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Apoptosis KW - Drosophila melanogaster UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Investigating+the+Role+of+Evil%2C+a+Drosophila+Melanogaster+Homologue+of+Human+BAG-Family+Proteins%2C+in+Apoptosis&rft.au=Mai%2C+Shu-Fen%3BFrueauf%2C+Jeremiah+B%3BAderson%2C+Ellen+M%3BVrailas%2C+Alysia+D%3BDavidson%2C+Florence%3BKohn%2C+Elise+C&rft.aulast=Mai&rft.aufirst=Shu-Fen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphism of Gnes Rlated to Insulin Sensitivity and the Risk or Biliary Tract Cancer and Biliary Stones: A Population-Based Case -Control Study in Shanghai, China T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964190; 4187203 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chang, Shih-Chen AU - Gao, Yu-Tang AU - Rashid, Asif AU - Sakoda, Lori AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Leitzmann, Michael F AU - Androetti, Gabriella AU - Chen, BingShu E AU - Rosenberg, Philip AU - Chen, Jinbo AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Fraumeni Jr, Joseph F AU - Hsing, Ann W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - Insulin KW - Biliary tract KW - Biopolymorphism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Polymorphism+of+Gnes+Rlated+to+Insulin+Sensitivity+and+the+Risk+or+Biliary+Tract+Cancer+and+Biliary+Stones%3A+A+Population-Based+Case+-Control+Study+in+Shanghai%2C+China&rft.au=Chang%2C+Shih-Chen%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BSakoda%2C+Lori%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BLeitzmann%2C+Michael+F%3BAndroetti%2C+Gabriella%3BChen%2C+BingShu+E%3BRosenberg%2C+Philip%3BChen%2C+Jinbo%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BFraumeni+Jr%2C+Joseph+F%3BHsing%2C+Ann+W&rft.aulast=Chang&rft.aufirst=Shih-Chen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination of Effects of Calorie Restriction and Exercise on Mammary Gland Gene Expression in C57BL/6 Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39963597; 4186213 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Padovani, Michela AU - Lavigne, Jackie A AU - Chandramouli, Gadisetti V.R. AU - Perkins, Susan N AU - Barrett, Carl J AU - Hursting, Stephen D AU - Bennett, Michelle L AU - Berrigan, David Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Gene expression KW - Mammary gland KW - Calories KW - Physical training KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39963597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Combination+of+Effects+of+Calorie+Restriction+and+Exercise+on+Mammary+Gland+Gene+Expression+in+C57BL%2F6+Mice&rft.au=Padovani%2C+Michela%3BLavigne%2C+Jackie+A%3BChandramouli%2C+Gadisetti+V.R.%3BPerkins%2C+Susan+N%3BBarrett%2C+Carl+J%3BHursting%2C+Stephen+D%3BBennett%2C+Michelle+L%3BBerrigan%2C+David&rft.aulast=Padovani&rft.aufirst=Michela&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mre11 is Commonly Inactivated in Human Colon Carcinoma Cells and is Required to Stabilize Rad50-Nbs1 and to Cooperate with ATM to Activate Chk2 in Response to Replication-Dependent DNA Double-Strand Breaks T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39962916; 4183540 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pommier, Yves G AU - Takemura, Haruyuki AU - Rao, Ashutosh AU - Sordet, Olivier AU - Furuta, Takahisa AU - Meng, Linghua AU - Miao, Zehong AU - Zhang, Hongliang Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Colon KW - DNA damage KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39962916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mre11+is+Commonly+Inactivated+in+Human+Colon+Carcinoma+Cells+and+is+Required+to+Stabilize+Rad50-Nbs1+and+to+Cooperate+with+ATM+to+Activate+Chk2+in+Response+to+Replication-Dependent+DNA+Double-Strand+Breaks&rft.au=Pommier%2C+Yves+G%3BTakemura%2C+Haruyuki%3BRao%2C+Ashutosh%3BSordet%2C+Olivier%3BFuruta%2C+Takahisa%3BMeng%2C+Linghua%3BMiao%2C+Zehong%3BZhang%2C+Hongliang&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resistance of PPARa to Wy-14,643-Induced Liver Tumorigenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39962354; 4184809 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Morimura, Keiichirou AU - Cheung, Connie AU - Ward, Jerrold M AU - Reddy, Janardan K AU - Gonzalez, Frank J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Liver KW - Tumorigenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39962354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Resistance+of+PPARa+to+Wy-14%2C643-Induced+Liver+Tumorigenesis&rft.au=Morimura%2C+Keiichirou%3BCheung%2C+Connie%3BWard%2C+Jerrold+M%3BReddy%2C+Janardan+K%3BGonzalez%2C+Frank+J&rft.aulast=Morimura&rft.aufirst=Keiichirou&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of Tumor Redox Status in Mice with Magnetic Resonance Imaging: Nitroxides as Functional Redox-Sensitive Contrast Agents T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39961637; 4184721 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - Hyodo, Fuminori AU - Koretsky, Alan P AU - Sowers, Anastasia L AU - Mitchell, James B AU - Krishna, Murali C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Magnetic resonance imaging KW - Contrast media KW - Nitroxide KW - Tumors KW - Redox reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Assessment+of+Tumor+Redox+Status+in+Mice+with+Magnetic+Resonance+Imaging%3A+Nitroxides+as+Functional+Redox-Sensitive+Contrast+Agents&rft.au=Matsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BHyodo%2C+Fuminori%3BKoretsky%2C+Alan+P%3BSowers%2C+Anastasia+L%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Matsumoto&rft.aufirst=Ken-ichiro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association between Birthweight and Puberty Onset Among Girls in the United States T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39961316; 4185251 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Olivo-Marston, Susan E AU - Graubard, Barry AU - Forman, Michele R Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - USA KW - Puberty UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Association+between+Birthweight+and+Puberty+Onset+Among+Girls+in+the+United+States&rft.au=Olivo-Marston%2C+Susan+E%3BGraubard%2C+Barry%3BForman%2C+Michele+R&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cu/Zn Superoxide Dismutase Confers Resistance to the Anti-Leukemic Agent Adaphostin (NSC680410) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39961239; 4184574 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Stockwin, Luke H AU - Bumke, Maja A AU - Yu, Sherry X AU - Webb, Simon AU - Collins, Jack R AU - Hollingshead, Mellinda AU - NewtonDianne, L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Zinc KW - Superoxide dismutase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cu%2FZn+Superoxide+Dismutase+Confers+Resistance+to+the+Anti-Leukemic+Agent+Adaphostin+%28NSC680410%29&rft.au=Stockwin%2C+Luke+H%3BBumke%2C+Maja+A%3BYu%2C+Sherry+X%3BWebb%2C+Simon%3BCollins%2C+Jack+R%3BHollingshead%2C+Mellinda%3BNewtonDianne%2C+L&rft.aulast=Stockwin&rft.aufirst=Luke&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profiling of the Lipid-Based Akt Inhibitors Phosphatidylinositol Ether Lipid Analogues (PIAs) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39961187; 4184572 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zhang, Chunyu AU - Elkahloun, Abdel G AU - Liao, Hongling AU - Delaney, Shannon AU - Dennis, Phillip A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ethers KW - Lipids KW - Phosphatidylinositol KW - AKT protein KW - Inhibitors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Expression+Profiling+of+the+Lipid-Based+Akt+Inhibitors+Phosphatidylinositol+Ether+Lipid+Analogues+%28PIAs%29&rft.au=Zhang%2C+Chunyu%3BElkahloun%2C+Abdel+G%3BLiao%2C+Hongling%3BDelaney%2C+Shannon%3BDennis%2C+Phillip+A&rft.aulast=Zhang&rft.aufirst=Chunyu&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nicotine-Induced Progression of Prostate Cancer through Activation of the Akt Signaling Pathway T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39960889; 4183099 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Prueitt, Robyn L AU - Howe, Tiffany M AU - Ambs, Stefan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prostate cancer KW - Signal transduction KW - AKT protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39960889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nicotine-Induced+Progression+of+Prostate+Cancer+through+Activation+of+the+Akt+Signaling+Pathway&rft.au=Prueitt%2C+Robyn+L%3BHowe%2C+Tiffany+M%3BAmbs%2C+Stefan&rft.aulast=Prueitt&rft.aufirst=Robyn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ras Transformation is Associated with Down-Regulation of C/EBPb Expression in Immortalized Fibroblasts T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39958438; 4183572 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sebastian, Thomas AU - Johnson, Peter F Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Fibroblasts KW - Ras protein KW - Transformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Ras+Transformation+is+Associated+with+Down-Regulation+of+C%2FEBPb+Expression+in+Immortalized+Fibroblasts&rft.au=Sebastian%2C+Thomas%3BJohnson%2C+Peter+F&rft.aulast=Sebastian&rft.aufirst=Thomas&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Characterization of BRG1: Distinct Regions Required for Chromatin Remodeling and Transcription T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39957049; 4182278 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Trotter, Kevin AU - Archer, Trevor K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Chromatin remodeling KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39957049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Characterization+of+BRG1%3A+Distinct+Regions+Required+for+Chromatin+Remodeling+and+Transcription&rft.au=Trotter%2C+Kevin%3BArcher%2C+Trevor+K&rft.aulast=Trotter&rft.aufirst=Kevin&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Construction of a Human-BAC Array for a High Resolution Analysis of Genomic Changes in Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39956904; 4181639 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rodriguez, Virginia W AU - Elkahloun, Abdel AU - Dutra, Amalia AU - Pak, Evgenia AU - Chandrasekharappa, Settara Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Construction+of+a+Human-BAC+Array+for+a+High+Resolution+Analysis+of+Genomic+Changes+in+Cancer&rft.au=Rodriguez%2C+Virginia+W%3BElkahloun%2C+Abdel%3BDutra%2C+Amalia%3BPak%2C+Evgenia%3BChandrasekharappa%2C+Settara&rft.aulast=Rodriguez&rft.aufirst=Virginia&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of DLC-1 Tumor Suppressor Gene Expression in Breast Cancer Cells by Proapoptotic Dietary Flavone and its Potential Implication in Chemoprevetion T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955274; 4182990 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ullmannova, Veronika AU - Popescu, Nicolae C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Flavones KW - Tumor suppressor genes KW - Gene expression KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+DLC-1+Tumor+Suppressor+Gene+Expression+in+Breast+Cancer+Cells+by+Proapoptotic+Dietary+Flavone+and+its+Potential+Implication+in+Chemoprevetion&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicolae+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Protein Complexes Involved in Transcription-Coupled Repair T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39950773; 4183558 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Bradsher, John N AU - Zhang, Ran AU - Wang, Xin W AU - Harris, Curt C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Transcription-coupled repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39950773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Isolation+of+Protein+Complexes+Involved+in+Transcription-Coupled+Repair&rft.au=Bradsher%2C+John+N%3BZhang%2C+Ran%3BWang%2C+Xin+W%3BHarris%2C+Curt+C&rft.aulast=Bradsher&rft.aufirst=John&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitochondrial DNA Repair T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949902; 4181536 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Van Houten, Bennett Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mitochondrial DNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mitochondrial+DNA+Repair&rft.au=Van+Houten%2C+Bennett&rft.aulast=Van+Houten&rft.aufirst=Bennett&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ABCG2 Expression, Function and a SNP Variant in the NCI Drug Screen Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949416; 4181956 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Deeken, John F AU - Robey, Rob AU - Zhan, Zhirong AU - Bates, Susan E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Single-nucleotide polymorphism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=ABCG2+Expression%2C+Function+and+a+SNP+Variant+in+the+NCI+Drug+Screen+Cell+Lines&rft.au=Deeken%2C+John+F%3BRobey%2C+Rob%3BZhan%2C+Zhirong%3BBates%2C+Susan+E&rft.aulast=Deeken&rft.aufirst=John&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between TP53 Polymorphisms and Haplotype with Lung Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949218; 4181913 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Mechanic, Leah E AU - Bowman, Elise D AU - Khan, Mohammed AU - Welsh, Judith AU - Burdette, Laurie AU - Chanock, Stephen AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - P53 protein KW - Gene polymorphism KW - Haplotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Association+between+TP53+Polymorphisms+and+Haplotype+with+Lung+Cancer&rft.au=Mechanic%2C+Leah+E%3BBowman%2C+Elise+D%3BKhan%2C+Mohammed%3BWelsh%2C+Judith%3BBurdette%2C+Laurie%3BChanock%2C+Stephen%3BHarris%2C+Curtis+C&rft.aulast=Mechanic&rft.aufirst=Leah&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated Risk of Lung Cancer Among People with AIDS T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949138; 4181902 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chaturvedi, Anil AU - Chang, Leonard AU - Pfeiffer, Ruth AU - Goedert, James AU - Engels, Eric Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Acquired immune deficiency syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Elevated+Risk+of+Lung+Cancer+Among+People+with+AIDS&rft.au=Chaturvedi%2C+Anil%3BChang%2C+Leonard%3BPfeiffer%2C+Ruth%3BGoedert%2C+James%3BEngels%2C+Eric&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Costimulatory Modalities Enhance CTL Avidity T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39947427; 4185902 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Garnett, Charlie T AU - Chakraborty, Mala AU - Kudo-Saito, Chie AU - Schlom, Jeffrey AU - Hodge, James W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Avidity KW - Cytotoxicity KW - Lymphocytes T UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39947427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Multiple+Costimulatory+Modalities+Enhance+CTL+Avidity&rft.au=Garnett%2C+Charlie+T%3BChakraborty%2C+Mala%3BKudo-Saito%2C+Chie%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Garnett&rft.aufirst=Charlie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Conserved Residues within the D- and H-loop in the ATP Sites for the Catalytic Cycle of ATP Hydrolysis by Human P-Glycoprotein (ABCB1) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39944415; 4181947 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, In-Wha AU - Sauna, Zuben E AU - AmbudkarSuresh, V Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Residues KW - Hydrolysis KW - ATP KW - P-Glycoprotein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Role+of+Conserved+Residues+within+the+D-+and+H-loop+in+the+ATP+Sites+for+the+Catalytic+Cycle+of+ATP+Hydrolysis+by+Human+P-Glycoprotein+%28ABCB1%29&rft.au=Kim%2C+In-Wha%3BSauna%2C+Zuben+E%3BAmbudkarSuresh%2C+V&rft.aulast=Kim&rft.aufirst=In-Wha&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Presentation Title: Imaging as a Biomarker in Cancer Therapy Trials: Overview T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39943122; 4181450 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sullivan, Daniel C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bioindicators KW - Cancer KW - Reviews KW - Imaging techniques KW - Biomarkers KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39943122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Presentation+Title%3A+Imaging+as+a+Biomarker+in+Cancer+Therapy+Trials%3A+Overview&rft.au=Sullivan%2C+Daniel+C&rft.aulast=Sullivan&rft.aufirst=Daniel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exercise Enhances Antigen Specific T Cell Responses in Both Systemic and Mucosal Compartments T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39941401; 4184158 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rogers, Connie J AU - Hance, Kenneth W AU - Zaharoff, David A AU - Perkins, Susan N AU - Schlom, Jeffrey AU - Hursting, Stephen D AU - Greiner, John W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphocytes T KW - Physical training KW - Antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39941401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Exercise+Enhances+Antigen+Specific+T+Cell+Responses+in+Both+Systemic+and+Mucosal+Compartments&rft.au=Rogers%2C+Connie+J%3BHance%2C+Kenneth+W%3BZaharoff%2C+David+A%3BPerkins%2C+Susan+N%3BSchlom%2C+Jeffrey%3BHursting%2C+Stephen+D%3BGreiner%2C+John+W&rft.aulast=Rogers&rft.aufirst=Connie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Signaling Network Analysis of Pharmacologic Epigenome Modification T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39937007; 4186579 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Killian, Jonathan K AU - Geho, David AU - Espina, Virginia AU - Speer, Runa AU - Wulfkuhle, Julia AU - Calvert, Valerie AU - Herrmann, Paul AU - Petricoin, Emmanuel F AU - Liotta, Lance A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction KW - Proteomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39937007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Signaling+Network+Analysis+of+Pharmacologic+Epigenome+Modification&rft.au=Killian%2C+Jonathan+K%3BGeho%2C+David%3BEspina%2C+Virginia%3BSpeer%2C+Runa%3BWulfkuhle%2C+Julia%3BCalvert%2C+Valerie%3BHerrmann%2C+Paul%3BPetricoin%2C+Emmanuel+F%3BLiotta%2C+Lance+A&rft.aulast=Killian&rft.aufirst=Jonathan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selected Base Excision Repair Gene Variants and Risk of Biliary Tract Cancers and Biliary Stones: A Population-Based Study T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39934397; 4185283 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Huang, Wen-Yi AU - Gao, Yu-Tang AU - Sakoda, Lori AU - Rashid, Asif AU - Deng, Jie AU - Sheng, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chanock, Stephen J AU - Fraumeni Jr, Joseph F AU - Hsing, Ann W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Base excision repair KW - Population studies KW - Biliary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Selected+Base+Excision+Repair+Gene+Variants+and+Risk+of+Biliary+Tract+Cancers+and+Biliary+Stones%3A+A+Population-Based+Study&rft.au=Huang%2C+Wen-Yi%3BGao%2C+Yu-Tang%3BSakoda%2C+Lori%3BRashid%2C+Asif%3BDeng%2C+Jie%3BSheng%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChanock%2C+Stephen+J%3BFraumeni+Jr%2C+Joseph+F%3BHsing%2C+Ann+W&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secondary Sexual Characteristics and Body Size at Different Ages in Relation to Risk of Prostate Cancer: Results from a Case-Control Study T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39934243; 4185248 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Barba, Maddalena AU - Terrenato, Irene AU - Fuhrman, Barbara AU - Teter, Barbara AU - Schuenemann, Holger J AU - Muti, Paola Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prostate cancer KW - Body size UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Secondary+Sexual+Characteristics+and+Body+Size+at+Different+Ages+in+Relation+to+Risk+of+Prostate+Cancer%3A+Results+from+a+Case-Control+Study&rft.au=Barba%2C+Maddalena%3BTerrenato%2C+Irene%3BFuhrman%2C+Barbara%3BTeter%2C+Barbara%3BSchuenemann%2C+Holger+J%3BMuti%2C+Paola&rft.aulast=Barba&rft.aufirst=Maddalena&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - First Phase I Study of IL-7 Administration in Humans T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39933883; 4187115 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sportes, Claude AU - Babb, Rebecca AU - Krumlauf, Michael AU - Foruraghi, Ladan AU - Daub, Janine AU - Chow, Catherine AU - Fry, Terry AU - Hakim, Frances AU - Fleisher, Thomas AU - Brown, Magaret AU - Engel, Julie AU - Buffet, Renaud AU - Morre, Michel AU - Mackal, Crystal AU - Gress, Ronald Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Interleukin 7 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=First+Phase+I+Study+of+IL-7+Administration+in+Humans&rft.au=Sportes%2C+Claude%3BBabb%2C+Rebecca%3BKrumlauf%2C+Michael%3BForuraghi%2C+Ladan%3BDaub%2C+Janine%3BChow%2C+Catherine%3BFry%2C+Terry%3BHakim%2C+Frances%3BFleisher%2C+Thomas%3BBrown%2C+Magaret%3BEngel%2C+Julie%3BBuffet%2C+Renaud%3BMorre%2C+Michel%3BMackal%2C+Crystal%3BGress%2C+Ronald&rft.aulast=Sportes&rft.aufirst=Claude&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HKH40A (RTA 502) Potently Down-Regulates Ribonucleotide Reductase and Produces Tumor Regression In Vivo T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39932455; 4186347 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kosakowska-Cholody, Teresa AU - Meyer, Colin J AU - Wick, Michael J AU - Stinson, Sherman F AU - Monks, Anne P AU - Cholody, Wieslaw M AU - Haripraksha, Humcha AU - Michejda, Christopher J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ribonucleotide reductase KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=HKH40A+%28RTA+502%29+Potently+Down-Regulates+Ribonucleotide+Reductase+and+Produces+Tumor+Regression+In+Vivo&rft.au=Kosakowska-Cholody%2C+Teresa%3BMeyer%2C+Colin+J%3BWick%2C+Michael+J%3BStinson%2C+Sherman+F%3BMonks%2C+Anne+P%3BCholody%2C+Wieslaw+M%3BHaripraksha%2C+Humcha%3BMichejda%2C+Christopher+J&rft.aulast=Kosakowska-Cholody&rft.aufirst=Teresa&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blood: Collection, Shipment, Processing and Storage T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39931653; 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4181469 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Libutti, Steven K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Clinical trials KW - Imaging techniques KW - Angiogenesis KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Imaging+Angiogenesis+in+Preclinical+Models+and+Clinical+Trials&rft.au=Libutti%2C+Steven+K&rft.aulast=Libutti&rft.aufirst=Steven&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of the Ubiquitin System and the Challenge of Developing Inhibitors of Substratespecific Ubiquitin Ligases T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39931515; 4181461 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Weissman, Allan M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ubiquitin KW - Reviews KW - Ubiquitin-protein ligase KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Overview+of+the+Ubiquitin+System+and+the+Challenge+of+Developing+Inhibitors+of+Substratespecific+Ubiquitin+Ligases&rft.au=Weissman%2C+Allan+M&rft.aulast=Weissman&rft.aufirst=Allan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Cloning and Characterization of Human Castor (CASZ1), a Novel Human Gene Encoding a Zinc Finger Protein T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39930751; 4182519 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Liu, Zhihui AU - Yang, Xuezhong AU - Cullion, Kathleen AU - Thiele, Carol J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Zinc finger proteins KW - Castor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Cloning+and+Characterization+of+Human+Castor+%28CASZ1%29%2C+a+Novel+Human+Gene+Encoding+a+Zinc+Finger+Protein&rft.au=Liu%2C+Zhihui%3BYang%2C+Xuezhong%3BCullion%2C+Kathleen%3BThiele%2C+Carol+J&rft.aulast=Liu&rft.aufirst=Zhihui&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VHL Suppresses Hepatocyte Growth Factor Stimulated Branching and Invasion Mediated by Beta Catenin T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39930606; 4183191 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Peruzzi, Benedetta AU - Athauda, Gagani P AU - Bottaro, Donald P Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocyte growth factor KW - VHL protein KW - Catenin KW - Hepatocytes KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=VHL+Suppresses+Hepatocyte+Growth+Factor+Stimulated+Branching+and+Invasion+Mediated+by+Beta+Catenin&rft.au=Peruzzi%2C+Benedetta%3BAthauda%2C+Gagani+P%3BBottaro%2C+Donald+P&rft.aulast=Peruzzi&rft.aufirst=Benedetta&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancers as Wounds that do Not Heal: Similarities and Differences between Renal Regeneration and Repair and Renal Cell Carcinoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39929864; 4182322 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Riss, Joseph AU - Khanna, Chand AU - Koo, Seongjoon AU - Chandramouli, Gadisetti V.R. AU - Yang, Howard H AU - Hu, Ying AU - Kleiner, David E AU - Rosenwald, Andreas AU - Schaefer, Carl F AU - Ben-Sasson, Shmuel A AU - Powell, John AU - Kane, David W AU - Star, Robert A AU - Aprelikova, Olga AU - Bauer, Kristin AU - Vasselli, James R AU - Maranchie, Jodi K AU - Kohn, Kurt W AU - Zeeberg, Barry R AU - Buetow, Ken H AU - Linehan, W Marston AU - Weinstein, John N AU - Lee, Maxwell P AU - Klausner, Richard D AU - Barrett, J Carl Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Wounds KW - Kidneys KW - Renal cell carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cancers+as+Wounds+that+do+Not+Heal%3A+Similarities+and+Differences+between+Renal+Regeneration+and+Repair+and+Renal+Cell+Carcinoma&rft.au=Riss%2C+Joseph%3BKhanna%2C+Chand%3BKoo%2C+Seongjoon%3BChandramouli%2C+Gadisetti+V.R.%3BYang%2C+Howard+H%3BHu%2C+Ying%3BKleiner%2C+David+E%3BRosenwald%2C+Andreas%3BSchaefer%2C+Carl+F%3BBen-Sasson%2C+Shmuel+A%3BPowell%2C+John%3BKane%2C+David+W%3BStar%2C+Robert+A%3BAprelikova%2C+Olga%3BBauer%2C+Kristin%3BVasselli%2C+James+R%3BMaranchie%2C+Jodi+K%3BKohn%2C+Kurt+W%3BZeeberg%2C+Barry+R%3BBuetow%2C+Ken+H%3BLinehan%2C+W+Marston%3BWeinstein%2C+John+N%3BLee%2C+Maxwell+P%3BKlausner%2C+Richard+D%3BBarrett%2C+J+Carl&rft.aulast=Riss&rft.aufirst=Joseph&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Cloning of Cisplatin Resistance Genes from KB-CP.5, a Cisplatin-Resistant Cell Line T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39929679; 4182842 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Suzuki, Toshihiro AU - Shen, Ding-Wu AU - Okabe, Mitsunori AU - Togawa, Tadayasu AU - Tanabe, Shinzo AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cisplatin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Functional+Cloning+of+Cisplatin+Resistance+Genes+from+KB-CP.5%2C+a+Cisplatin-Resistant+Cell+Line&rft.au=Suzuki%2C+Toshihiro%3BShen%2C+Ding-Wu%3BOkabe%2C+Mitsunori%3BTogawa%2C+Tadayasu%3BTanabe%2C+Shinzo%3BGottesman%2C+Michael+M&rft.aulast=Suzuki&rft.aufirst=Toshihiro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Biomarkers of Arsenic Exposure and Toxicity in Urine Using SELDI Technology T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39929522; 4182812 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Moore, Lee E AU - Skibola, Christine F AU - Hegedus, Christine AU - Skibola, Danica R AU - Pfeiffer, Ruth AU - Warner, Marcella AU - Clark, Michael AU - Steinmaus, Craig AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Smith, Martyn T AU - Smith, Allan H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Heavy metals KW - Bioindicators KW - Arsenic KW - Urine KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Biomarkers+of+Arsenic+Exposure+and+Toxicity+in+Urine+Using+SELDI+Technology&rft.au=Moore%2C+Lee+E%3BSkibola%2C+Christine+F%3BHegedus%2C+Christine%3BSkibola%2C+Danica+R%3BPfeiffer%2C+Ruth%3BWarner%2C+Marcella%3BClark%2C+Michael%3BSteinmaus%2C+Craig%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T%3BSmith%2C+Allan+H&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Study and Application of RNAi Against Cancer-Related Genes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928987; 4186075 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Martin, Scott E AU - Jones, Tamara L AU - Thomas, Cheryl L AU - Nguyen, Dac AU - Runfola, Timothy AU - Szakacs, Gergely AU - Gottesman, Michael M AU - Ludwig, Joseph A AU - Weinstein, John N AU - Gunsior, Michele AU - Goldsmith, Paul AU - Lader, Eric AU - Huppi, Konrad AU - Caplen, Natasha J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - RNA-mediated interference UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Study+and+Application+of+RNAi+Against+Cancer-Related+Genes&rft.au=Martin%2C+Scott+E%3BJones%2C+Tamara+L%3BThomas%2C+Cheryl+L%3BNguyen%2C+Dac%3BRunfola%2C+Timothy%3BSzakacs%2C+Gergely%3BGottesman%2C+Michael+M%3BLudwig%2C+Joseph+A%3BWeinstein%2C+John+N%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul%3BLader%2C+Eric%3BHuppi%2C+Konrad%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Haplotype Block in IGF2R Associated with Increased Risk For Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928596; 4187192 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Savage, Sharon A AU - Modi, William S AU - Douglass, Chester AU - Hoover, Robert N AU - Chanock, Stephen J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - Insulin-like growth factor II receptors KW - Haplotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+a+Haplotype+Block+in+IGF2R+Associated+with+Increased+Risk+For+Osteosarcoma&rft.au=Savage%2C+Sharon+A%3BModi%2C+William+S%3BDouglass%2C+Chester%3BHoover%2C+Robert+N%3BChanock%2C+Stephen+J&rft.aulast=Savage&rft.aufirst=Sharon&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phyloproteomics: What Phylogenetic Analysis Reveals about Serum Proteomics T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39927555; 4187096 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Abu-Asab, Mones AU - Chaouchi, Mohamed AU - Amri, Hakima Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Proteomics KW - Phylogenetics KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phyloproteomics%3A+What+Phylogenetic+Analysis+Reveals+about+Serum+Proteomics&rft.au=Abu-Asab%2C+Mones%3BChaouchi%2C+Mohamed%3BAmri%2C+Hakima&rft.aulast=Abu-Asab&rft.aufirst=Mones&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Common Variants in Genes that Mediate Inflammation and Multiple Myeloma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39926139; 4183961 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Brown, Elizabeth E AU - Lan, Qing AU - Zheng, Tongzhang AU - Zhang, Yawei AU - Wang, Sophia AU - Hoar-Zahm, Shelia AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Baris, Dalsu Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Inflammation KW - Multiple myeloma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Common+Variants+in+Genes+that+Mediate+Inflammation+and+Multiple+Myeloma&rft.au=Brown%2C+Elizabeth+E%3BLan%2C+Qing%3BZheng%2C+Tongzhang%3BZhang%2C+Yawei%3BWang%2C+Sophia%3BHoar-Zahm%2C+Shelia%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BBaris%2C+Dalsu&rft.aulast=Brown&rft.aufirst=Elizabeth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaphostin Disrupts Mitogenic and Anti-Apoptotic Signaling by NPM-ALK in Anaplastic Large Cell Lymphomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39925975; 4184503 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Burke, Jason AU - Shoemaker, Robert H AU - Kondapaka, Sudhir B Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Signal transduction KW - Anaplastic large-cell lymphoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Adaphostin+Disrupts+Mitogenic+and+Anti-Apoptotic+Signaling+by+NPM-ALK+in+Anaplastic+Large+Cell+Lymphomas&rft.au=Burke%2C+Jason%3BShoemaker%2C+Robert+H%3BKondapaka%2C+Sudhir+B&rft.aulast=Burke&rft.aufirst=Jason&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleotide Damage Proximal to DNA Double-Strand Break ends is a Stronger Inhibitor of Non-Homologous end Joining than Blocked 3 Ends T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39925603; 4186637 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Datta, Kamal AU - Neumann, Ronald D AU - Winters, Thomas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Non-homologous end joining KW - Nucleotides KW - DNA damage KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nucleotide+Damage+Proximal+to+DNA+Double-Strand+Break+ends+is+a+Stronger+Inhibitor+of+Non-Homologous+end+Joining+than+Blocked+3+Ends&rft.au=Datta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Datta&rft.aufirst=Kamal&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Biphasic Gene Expression Response to Cisplatin Treatment in Ovarian Cancer: An Immediate Early Gene Response Followed by a p53 Response T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39924798; 4184584 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Jianghong AU - Wood, William AU - Becker, Kevin AU - Weeraratna, Ashani AU - Morin, Patrice J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Cisplatin KW - Gene expression KW - P53 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Biphasic+Gene+Expression+Response+to+Cisplatin+Treatment+in+Ovarian+Cancer%3A+An+Immediate+Early+Gene+Response+Followed+by+a+p53+Response&rft.au=Li%2C+Jianghong%3BWood%2C+William%3BBecker%2C+Kevin%3BWeeraratna%2C+Ashani%3BMorin%2C+Patrice+J&rft.aulast=Li&rft.aufirst=Jianghong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Large-Scale Evaluation of Candidate Genes for Urinary Bladder Cancer Susceptibility Using Illumina@@uRG@ in the Spanish Bladder Cancer Study T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39924258; 4186597 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Garcia-Closas, Montserrat AU - Rothman, Nathaniel AU - Malats, Nuria AU - Real, Francisco X AU - Welch, Robert AU - Yeager, Meredith AU - Silverman, Debra AU - Kogevinas, Manolis AU - Dosemeci, Mustafa AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Castano-Vinyals, Gemma AU - Chanock, Stephen Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Urine KW - Urinary bladder UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Large-Scale+Evaluation+of+Candidate+Genes+for+Urinary+Bladder+Cancer+Susceptibility+Using+Illumina%40%40uRG%40+in+the+Spanish+Bladder+Cancer+Study&rft.au=Garcia-Closas%2C+Montserrat%3BRothman%2C+Nathaniel%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BWelch%2C+Robert%3BYeager%2C+Meredith%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BDosemeci%2C+Mustafa%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BCastano-Vinyals%2C+Gemma%3BChanock%2C+Stephen&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do GRP Receptors Regulate Lung Carcinogenesis? T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39923659; 4184905 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Moody, Terry W AU - Jakowlew, Sonia AU - Purdom, Sally AU - Walters, James AU - Hampton, Lori AU - Battey, James AU - Jensen, Robert Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Carcinogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Do+GRP+Receptors+Regulate+Lung+Carcinogenesis%3F&rft.au=Moody%2C+Terry+W%3BJakowlew%2C+Sonia%3BPurdom%2C+Sally%3BWalters%2C+James%3BHampton%2C+Lori%3BBattey%2C+James%3BJensen%2C+Robert&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatin Protein Dynamics in Pluripotent Stem Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39922517; 4184873 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Misteli, Tom Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Chromatin KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chromatin+Protein+Dynamics+in+Pluripotent+Stem+Cells&rft.au=Misteli%2C+Tom&rft.aulast=Misteli&rft.aufirst=Tom&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential Tumor Suppressor Genes Identified by Gene Expression Profiling of Microdissected Serous Ovarian Tumor Tissue and 5-Aza-2'-Deoxycytidine Treated Serous Ovarian Cancer Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39921907; 4185053 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Stephen P AU - Ozbun, Laurent L AU - Kwong, Joseph AU - Bonome, Tomas AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Gene expression KW - Tumor cell lines KW - Tumor suppressor genes KW - 5-aza-2'-deoxycytidine KW - Tumors KW - Suppressors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Potential+Tumor+Suppressor+Genes+Identified+by+Gene+Expression+Profiling+of+Microdissected+Serous+Ovarian+Tumor+Tissue+and+5-Aza-2%27-Deoxycytidine+Treated+Serous+Ovarian+Cancer+Cell+Lines&rft.au=Yang%2C+Stephen+P%3BOzbun%2C+Laurent+L%3BKwong%2C+Joseph%3BBonome%2C+Tomas%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Yang&rft.aufirst=Stephen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Expression of Myeloid Markers by Modulation of an Isoprenyl Pathway T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39921770; 4182953 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Caruccio, Lorraine AU - Stroncek, David Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Antitumor agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Altered+Expression+of+Myeloid+Markers+by+Modulation+of+an+Isoprenyl+Pathway&rft.au=Caruccio%2C+Lorraine%3BStroncek%2C+David&rft.aulast=Caruccio&rft.aufirst=Lorraine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39921292; 4185860 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ludwig IV, Joseph A AU - Szakacs, Gergely AU - Martin, Scott E AU - Caplen, Natasha J AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Cancer KW - Multidrug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Selective+Toxicity+of+NSC73306+in+MDR1-Positive+Cells+as+a+New+Strategy+to+Circumvent+Multidrug+Resistance+in+Cancer&rft.au=Ludwig+IV%2C+Joseph+A%3BSzakacs%2C+Gergely%3BMartin%2C+Scott+E%3BCaplen%2C+Natasha+J%3BGottesman%2C+Michael+M&rft.aulast=Ludwig+IV&rft.aufirst=Joseph&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mining of Biomarkers from Archival Formalin-Fixed Paraffin-Embedded Tissue Sections by Multiplex Tissue Immunoblotting T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39918863; 4182699 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chung, Joon-Yong AU - Braunschweig, Till AU - Hu, Nan AU - Roth, Mark AU - Traicoff, June L AU - Knezevic, Vladimir AU - Taylor, Philip R AU - Hewitt, Stephen M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bioindicators KW - Immunoblotting KW - Biomarkers KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mining+of+Biomarkers+from+Archival+Formalin-Fixed+Paraffin-Embedded+Tissue+Sections+by+Multiplex+Tissue+Immunoblotting&rft.au=Chung%2C+Joon-Yong%3BBraunschweig%2C+Till%3BHu%2C+Nan%3BRoth%2C+Mark%3BTraicoff%2C+June+L%3BKnezevic%2C+Vladimir%3BTaylor%2C+Philip+R%3BHewitt%2C+Stephen+M&rft.aulast=Chung&rft.aufirst=Joon-Yong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Pathogenesis of Human Hepatocellular Carcinoma: Mechanistic and Prognostic Significance of Aberrant Methylation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39918121; 4182490 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Calvisi, Diego F AU - Ladu, Sara AU - Gorden, Alexis AU - Farina, Miriam AU - Lee, Ju-Seog AU - Conner, Elizabeth A AU - Schroeder, Insa S AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocellular carcinoma KW - Methylation KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Pathogenesis+of+Human+Hepatocellular+Carcinoma%3A+Mechanistic+and+Prognostic+Significance+of+Aberrant+Methylation&rft.au=Calvisi%2C+Diego+F%3BLadu%2C+Sara%3BGorden%2C+Alexis%3BFarina%2C+Miriam%3BLee%2C+Ju-Seog%3BConner%2C+Elizabeth+A%3BSchroeder%2C+Insa+S%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Calvisi&rft.aufirst=Diego&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - E-Cadherin Expression in Inflammatory Breast Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39917816; 4182737 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Sherry X AU - Wedam, Suparna B AU - Nguyen, Diana AU - Steinberg, Seth M AU - Sherman, Mark AU - Levine, Paul H AU - Swain, Sandra M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Inflammation KW - E-Cadherin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=E-Cadherin+Expression+in+Inflammatory+Breast+Cancer&rft.au=Yang%2C+Sherry+X%3BWedam%2C+Suparna+B%3BNguyen%2C+Diana%3BSteinberg%2C+Seth+M%3BSherman%2C+Mark%3BLevine%2C+Paul+H%3BSwain%2C+Sandra+M&rft.aulast=Yang&rft.aufirst=Sherry&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in Carcinogen Metabolizing Enzymes and Bladder Cancer Risk T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39917118; 4182813 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Figueroa, Jonine AU - Malats, Nuria AU - Real, Francisco AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Welch, Robert AU - Dosemeci, Mustafa AU - Lan, Qing AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Castano-Vinyals, Gemma AU - Rothman, Nathaniel AU - Garcia-Closas, Montserrat Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Carcinogens KW - Cancer KW - Enzymes KW - Urinary bladder KW - Genetic diversity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Genetic+Variation+in+Carcinogen+Metabolizing+Enzymes+and+Bladder+Cancer+Risk&rft.au=Figueroa%2C+Jonine%3BMalats%2C+Nuria%3BReal%2C+Francisco%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BLan%2C+Qing%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BCastano-Vinyals%2C+Gemma%3BRothman%2C+Nathaniel%3BGarcia-Closas%2C+Montserrat&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of the Interleukin-1 Signal Transduction Pathway Significantly Contributes to Nuclear Factor kB Activity in Human Head and Neck Squamous Cell Carcinoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39911971; 4183044 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Bagain, Lorena AU - Nicholas-Figueroa, Linda AU - Yang, XingPing AU - Chen, Zhong AU - VanWaes, Carter Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction KW - Interleukin 1 KW - Squamous cell carcinoma KW - NF-^KB protein KW - Head and neck cancer KW - Tumors KW - Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Activation+of+the+Interleukin-1+Signal+Transduction+Pathway+Significantly+Contributes+to+Nuclear+Factor+kB+Activity+in+Human+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Bagain%2C+Lorena%3BNicholas-Figueroa%2C+Linda%3BYang%2C+XingPing%3BChen%2C+Zhong%3BVanWaes%2C+Carter&rft.aulast=Bagain&rft.aufirst=Lorena&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Melanoma Associated Fibroblasts Promote Melanoma Invasiveness: Possible Cross Talk between CXCR4 and VEGF Receptor T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39905487; 4181701 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Giuliano Jr, Paola AU - Ierano, Caterina AU - Ascierto, Paolo Antonio AU - Napolitano, Maria AU - Lombardi, Marisa AU - Liguori, Monica AU - Calemma, Rosa AU - Simeone, Ester AU - Mauro, Francesca AU - Aloj, Luigi AU - Ottaiano, Alessandro AU - Castello, Giuseppe Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Melanoma KW - Fibroblasts KW - Invasiveness KW - CXCR4 protein KW - Vascular endothelial growth factor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Melanoma+Associated+Fibroblasts+Promote+Melanoma+Invasiveness%3A+Possible+Cross+Talk+between+CXCR4+and+VEGF+Receptor&rft.au=Giuliano+Jr%2C+Paola%3BIerano%2C+Caterina%3BAscierto%2C+Paolo+Antonio%3BNapolitano%2C+Maria%3BLombardi%2C+Marisa%3BLiguori%2C+Monica%3BCalemma%2C+Rosa%3BSimeone%2C+Ester%3BMauro%2C+Francesca%3BAloj%2C+Luigi%3BOttaiano%2C+Alessandro%3BCastello%2C+Giuseppe&rft.aulast=Giuliano+Jr&rft.aufirst=Paola&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topographical Analysis of GSTP1 Methylation Patterns in the Stroma of Prostatic Carcinomas Using Laser Capture Microdissection (LCM) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39903369; 4181728 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rodriguez-canales, Jaime AU - Richardson, Annely AU - Hanson, Jeffrey AU - Wallis, Benjamin AU - Tangrea, Michael AU - Gillespie, John W AU - Erickson, Heidi S AU - Josephson, John W AU - Gannot, Gallya AU - Pinto, Peter A AU - Linehan, W Marston AU - Woodson, Karen AU - Emmert-Buck, Michael AU - Chuaqui, Rodrigo F Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lasers KW - Stroma KW - Glutathione transferase KW - Methylation KW - Carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Topographical+Analysis+of+GSTP1+Methylation+Patterns+in+the+Stroma+of+Prostatic+Carcinomas+Using+Laser+Capture+Microdissection+%28LCM%29&rft.au=Rodriguez-canales%2C+Jaime%3BRichardson%2C+Annely%3BHanson%2C+Jeffrey%3BWallis%2C+Benjamin%3BTangrea%2C+Michael%3BGillespie%2C+John+W%3BErickson%2C+Heidi+S%3BJosephson%2C+John+W%3BGannot%2C+Gallya%3BPinto%2C+Peter+A%3BLinehan%2C+W+Marston%3BWoodson%2C+Karen%3BEmmert-Buck%2C+Michael%3BChuaqui%2C+Rodrigo+F&rft.aulast=Rodriguez-canales&rft.aufirst=Jaime&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Paternal Preconceptional Exposure to Chromium(III) on Methylation and Expression of the 45S Ribosomal RNA Gene in Lungs and Livers of Offspring T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39897777; 4185554 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wang, Cuiju AU - Choe, Jihee AU - Anderson, Lucy M AU - Shiao, Yih-Horng Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Offspring KW - Lung KW - Liver KW - Progeny KW - RRNA 45S KW - DNA methylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Effects+of+Paternal+Preconceptional+Exposure+to+Chromium%28III%29+on+Methylation+and+Expression+of+the+45S+Ribosomal+RNA+Gene+in+Lungs+and+Livers+of+Offspring&rft.au=Wang%2C+Cuiju%3BChoe%2C+Jihee%3BAnderson%2C+Lucy+M%3BShiao%2C+Yih-Horng&rft.aulast=Wang&rft.aufirst=Cuiju&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radicals, Inflammation and Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39897416; 4181490 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Radicals KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Radicals%2C+Inflammation+and+Cancer&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signal Transduction by Reactive Oxygen Species: Implications for Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39897356; 4181488 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Finkel, Toren Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Reactive oxygen species KW - Cancer KW - Signal transduction KW - Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Signal+Transduction+by+Reactive+Oxygen+Species%3A+Implications+for+Cancer&rft.au=Finkel%2C+Toren&rft.aulast=Finkel&rft.aufirst=Toren&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Harnessing Transposons for Cancer Gene Discovery T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39896966; 4181413 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jenkins, Nancy A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Transposons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Harnessing+Transposons+for+Cancer+Gene+Discovery&rft.au=Jenkins%2C+Nancy+A&rft.aulast=Jenkins&rft.aufirst=Nancy&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Microarray Analysis of Gene Expression in PC3 Prostate Carcinoma Cells Following Treatment with NSAIDs Ibuprofen and COX-2 Specific NS398 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39894908; 4181585 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Aryankalayil, Moly John AU - Palayoor, Sanjeewani T AU - Coleman, C Norman Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prostate carcinoma KW - Gene expression KW - DNA microarrays KW - Ibuprofen KW - Cyclooxygenase-2 KW - Nonsteroidal antiinflammatory drugs KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Comparative+Microarray+Analysis+of+Gene+Expression+in+PC3+Prostate+Carcinoma+Cells+Following+Treatment+with+NSAIDs+Ibuprofen+and+COX-2+Specific+NS398&rft.au=Aryankalayil%2C+Moly+John%3BPalayoor%2C+Sanjeewani+T%3BColeman%2C+C+Norman&rft.aulast=Aryankalayil&rft.aufirst=Moly&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hepatitis C Virus (HCV) Infection and Risk of Post-Transplant Lymphoproliferative Disorder (PTLD) After Liver Transplantation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39894092; 4181900 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Morton, Lindsay M AU - Landgren, Ola AU - Chatterjee, Nilanjan AU - Castenson, David AU - Parsons, Ruth AU - Hoover, Robert N AU - Engels, Eric A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatitis KW - Infectious diseases KW - Liver KW - Immunoproliferative diseases KW - Posttransplant lymphoproliferative disorders KW - Transplantation KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Hepatitis+C+Virus+%28HCV%29+Infection+and+Risk+of+Post-Transplant+Lymphoproliferative+Disorder+%28PTLD%29+After+Liver+Transplantation&rft.au=Morton%2C+Lindsay+M%3BLandgren%2C+Ola%3BChatterjee%2C+Nilanjan%3BCastenson%2C+David%3BParsons%2C+Ruth%3BHoover%2C+Robert+N%3BEngels%2C+Eric+A&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxic Gene Therapy of Esophageal Cancers Using the Recombinant RGD-Modified Adenovirus Expressing Membrane-Bound TRAIL (TNF-Related Apoptosis-Inducing Ligand): An In Vitro and In Vivo Analysis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39893714; 4187308 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Nguyen, Duc M AU - Sehgal, Shailen AU - Fang, Bingliang AU - Schrump, David S AU - Nguyen, Dao M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - TRAIL protein KW - Cytotoxicity KW - Gene therapy KW - Ligands KW - Recombinants KW - Adenovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cytotoxic+Gene+Therapy+of+Esophageal+Cancers+Using+the+Recombinant+RGD-Modified+Adenovirus+Expressing+Membrane-Bound+TRAIL+%28TNF-Related+Apoptosis-Inducing+Ligand%29%3A+An+In+Vitro+and+In+Vivo+Analysis&rft.au=Yeow%2C+Wen-Shuz%3BChua%2C+Alex%3BNguyen%2C+Duc+M%3BSehgal%2C+Shailen%3BFang%2C+Bingliang%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Yeow&rft.aufirst=Wen-Shuz&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemoprevention and Therapeutic Treatment of BRCA1 Associated Breast Cancer in Conditional Knockout Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892871; 4182102 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Tominaga, Yohei AU - De Soto III, Joseph A. AU - Wang, Rui-Hong AU - Deng, Chu-Xia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Breast cancer KW - BRCA1 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chemoprevention+and+Therapeutic+Treatment+of+BRCA1+Associated+Breast+Cancer+in+Conditional+Knockout+Mice&rft.au=Tominaga%2C+Yohei%3BDe+Soto+III%2C+Joseph+A.%3BWang%2C+Rui-Hong%3BDeng%2C+Chu-Xia&rft.aulast=Tominaga&rft.aufirst=Yohei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Regulation of Alternative Programs of Cell Death T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39891718; 4186149 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lenardo, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mortality KW - Cell death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Regulation+of+Alternative+Programs+of+Cell+Death&rft.au=Lenardo%2C+Michael+J&rft.aulast=Lenardo&rft.aufirst=Michael&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prediction of Metastatic Potential, Recurrence and Prognosis in Hepatocellular Carcinoma Based on a Unique Immune Response Signature of the Liver Microenvironment T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39886039; 4184859 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Budhu, Anuradha S AU - Forgues, Marshonna AU - Ye, Qing-hai AU - Jia, Hu-liang AU - He, Ping AU - Zanetti, Krista AU - Kammula, Udai AU - Chen, Yidong AU - Qin, Lun-Xiu AU - Tang, Zhao-You AU - Wang, Xin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Liver KW - Immune response KW - Hepatocellular carcinoma KW - Microenvironments KW - Prognosis KW - Metastases KW - Tumors KW - Immunity KW - Defense mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39886039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Prediction+of+Metastatic+Potential%2C+Recurrence+and+Prognosis+in+Hepatocellular+Carcinoma+Based+on+a+Unique+Immune+Response+Signature+of+the+Liver+Microenvironment&rft.au=Budhu%2C+Anuradha+S%3BForgues%2C+Marshonna%3BYe%2C+Qing-hai%3BJia%2C+Hu-liang%3BHe%2C+Ping%3BZanetti%2C+Krista%3BKammula%2C+Udai%3BChen%2C+Yidong%3BQin%2C+Lun-Xiu%3BTang%2C+Zhao-You%3BWang%2C+Xin&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Resolution Oligonucleotide Array CGH Analysis of the NCI-60 Cell Line Panel T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885585; 4187027 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Weinstein, John N AU - Reinhold, William C AU - Bussey, Kimberly J AU - Reimers, Mark AU - Selzer, Rebecca R AU - Richmond, Todd A AU - Eis, Peggy S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - DNA microarrays UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=High-Resolution+Oligonucleotide+Array+CGH+Analysis+of+the+NCI-60+Cell+Line+Panel&rft.au=Weinstein%2C+John+N%3BReinhold%2C+William+C%3BBussey%2C+Kimberly+J%3BReimers%2C+Mark%3BSelzer%2C+Rebecca+R%3BRichmond%2C+Todd+A%3BEis%2C+Peggy+S&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo Molecular Imaging of Disseminated Peritoneal Cancer Microfoci Using a Targeted Optical Fluorescence Agent Conjugated to Avidin T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885354; 4184728 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Kamiya, Mako AU - Bernardo, Marcelino AU - Paik, Ronald S AU - Krishna, Murali C AU - Choyke, Peter L AU - Kobayashi, Hisataka Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Fluorescence KW - Cancer KW - Imaging techniques KW - Avidin KW - Peritoneum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=In+vivo+Molecular+Imaging+of+Disseminated+Peritoneal+Cancer+Microfoci+Using+a+Targeted+Optical+Fluorescence+Agent+Conjugated+to+Avidin&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BKamiya%2C+Mako%3BBernardo%2C+Marcelino%3BPaik%2C+Ronald+S%3BKrishna%2C+Murali+C%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Illumina@@uRG@ - Based Multiplexed Genotyping Indicates a Role for Altered DNA Repair and Genomic Maintenance in Susceptibility to Benzene Toxicity T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885163; 4185261 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lan, Qing AU - Smith, Martyn T AU - Shen, Min AU - Zhang, Luoping AU - Li, Guilan AU - Vermeulen, Roel AU - Rappaport, Stephen M AU - Hayes, Richard AU - Linet, Martha AU - Alter, Blanche P AU - Yin, Songnian AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Rothmann, Nathaniel Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Benzene KW - Genotyping KW - Genomics KW - DNA repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Illumina%40%40uRG%40+-+Based+Multiplexed+Genotyping+Indicates+a+Role+for+Altered+DNA+Repair+and+Genomic+Maintenance+in+Susceptibility+to+Benzene+Toxicity&rft.au=Lan%2C+Qing%3BSmith%2C+Martyn+T%3BShen%2C+Min%3BZhang%2C+Luoping%3BLi%2C+Guilan%3BVermeulen%2C+Roel%3BRappaport%2C+Stephen+M%3BHayes%2C+Richard%3BLinet%2C+Martha%3BAlter%2C+Blanche+P%3BYin%2C+Songnian%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BRothmann%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Gene Expression Analysis of Canine and Human Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39881897; 4182317 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Paoloni, Melissa AU - Khanna, Chand AU - Davis, Sean AU - Meltzer, Paul Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Osteosarcoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39881897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Comparative+Gene+Expression+Analysis+of+Canine+and+Human+Osteosarcoma&rft.au=Paoloni%2C+Melissa%3BKhanna%2C+Chand%3BDavis%2C+Sean%3BMeltzer%2C+Paul&rft.aulast=Paoloni&rft.aufirst=Melissa&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Germline Polymorphism and Tumor Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879988; 4187543 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hunter, Kent W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Metastases KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Germline+Polymorphism+and+Tumor+Metastasis&rft.au=Hunter%2C+Kent+W&rft.aulast=Hunter&rft.aufirst=Kent&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Enhancement of Human Cancer Cells by Guggulsterone T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879712; 4186059 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Choudhuri, Rajani AU - DeGraff, William AU - Mitchell, James B AU - Cook, John A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Radiation+Enhancement+of+Human+Cancer+Cells+by+Guggulsterone&rft.au=Choudhuri%2C+Rajani%3BDeGraff%2C+William%3BMitchell%2C+James+B%3BCook%2C+John+A&rft.aulast=Choudhuri&rft.aufirst=Rajani&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Cholangiocellular Carcinoma by Liver Specific Disruption of Smad4 and Pten in Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879256; 4185971 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Xu, Xiaoling AU - Qiao, Wenhui AU - Li, Cuiling AU - Xiao, Cuiying AU - Radaeva, Sevitlana AU - Wang, Rui-Hong AU - Stiles, Bangyan AU - LeRoith, Derek AU - Torbenson, Michael S AU - Wu, Hong AU - Gao, Bin AU - Deng, Chuxia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Liver KW - PTEN protein KW - Carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+Cholangiocellular+Carcinoma+by+Liver+Specific+Disruption+of+Smad4+and+Pten+in+Mice&rft.au=Xu%2C+Xiaoling%3BQiao%2C+Wenhui%3BLi%2C+Cuiling%3BXiao%2C+Cuiying%3BRadaeva%2C+Sevitlana%3BWang%2C+Rui-Hong%3BStiles%2C+Bangyan%3BLeRoith%2C+Derek%3BTorbenson%2C+Michael+S%3BWu%2C+Hong%3BGao%2C+Bin%3BDeng%2C+Chuxia&rft.aulast=Xu&rft.aufirst=Xiaoling&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Proteasome Inhibitor Bortezomib Sensitizes Human Tumor Cells to Apo2L/TRAIL-Mediated Apoptosis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879145; 4182339 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sayers, Thomas J AU - Brooks, Alan D AU - Ramirez, Teresa AU - Elliott, Peter J AU - Murphy, William J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor cells KW - Proteasome inhibitors KW - Apoptosis KW - Tumors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Proteasome+Inhibitor+Bortezomib+Sensitizes+Human+Tumor+Cells+to+Apo2L%2FTRAIL-Mediated+Apoptosis&rft.au=Sayers%2C+Thomas+J%3BBrooks%2C+Alan+D%3BRamirez%2C+Teresa%3BElliott%2C+Peter+J%3BMurphy%2C+William+J&rft.aulast=Sayers&rft.aufirst=Thomas&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systemic Radioimmunotherapy in Synergy with Vaccine Renders Antitumor Effects in a Preclinical Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39875073; 4183691 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chakraborty, Mala AU - Gelbard, Alexander AU - Carrasquillo, Jorge A AU - Yu, Sarah AU - Mamede, Marcelo AU - Paik, Chang H AU - Camphausen, Kevin AU - Schlom, Jeffrey AU - Hodge, James W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Systemic+Radioimmunotherapy+in+Synergy+with+Vaccine+Renders+Antitumor+Effects+in+a+Preclinical+Model&rft.au=Chakraborty%2C+Mala%3BGelbard%2C+Alexander%3BCarrasquillo%2C+Jorge+A%3BYu%2C+Sarah%3BMamede%2C+Marcelo%3BPaik%2C+Chang+H%3BCamphausen%2C+Kevin%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Chakraborty&rft.aufirst=Mala&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Minimal Residual Disease in Hairy Cell Leukemia Patients Treated by BL22 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39865777; 4183721 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Arons, Evgeny AU - Margulies, Inger AU - Sorbara, Lynn AU - Raffeld, Mark AU - Stetler-Stevenson, Maryalice AU - Pastan, Ira AU - Kreitman, Robert J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Leukemia KW - Hairy cell leukemia KW - Minimal residual disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Minimal+Residual+Disease+in+Hairy+Cell+Leukemia+Patients+Treated+by+BL22&rft.au=Arons%2C+Evgeny%3BMargulies%2C+Inger%3BSorbara%2C+Lynn%3BRaffeld%2C+Mark%3BStetler-Stevenson%2C+Maryalice%3BPastan%2C+Ira%3BKreitman%2C+Robert+J&rft.aulast=Arons&rft.aufirst=Evgeny&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unique microRNA Molecular Profiles in Lung Cancer Diagnosis and Prognosis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39865658; 4186815 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yanaihara, Nozomu AU - Caplen, Natasha AU - Bowman, Elise AU - Seike, Masahiro AU - Kumamoto, Kensuke AU - Yi, Ming AU - Stephens, Robert M AU - Okamoto, Aikou AU - Tanaka, Tadao AU - Yokota, Jun AU - Calin, George A AU - Liu, Chang-Gong AU - Croce, Carlo M AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - MiRNA KW - Prognosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Unique+microRNA+Molecular+Profiles+in+Lung+Cancer+Diagnosis+and+Prognosis&rft.au=Yanaihara%2C+Nozomu%3BCaplen%2C+Natasha%3BBowman%2C+Elise%3BSeike%2C+Masahiro%3BKumamoto%2C+Kensuke%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BOkamoto%2C+Aikou%3BTanaka%2C+Tadao%3BYokota%2C+Jun%3BCalin%2C+George+A%3BLiu%2C+Chang-Gong%3BCroce%2C+Carlo+M%3BHarris%2C+Curtis+C&rft.aulast=Yanaihara&rft.aufirst=Nozomu&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic, Genomic and Functional Characterization of Topoisomerase I siRNA Cell Lines Derived from Human Breast and Colon Carcinomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39865391; 4186770 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Miao, Ze_Hong AU - Player, Audrey AU - Shankavaram, Uma AU - Wang, Yong-Hong AU - Liao, Zhi-Yong AU - Zimonjic, Drazen AU - Zhang, HongLiang AU - Meng, Ling-Hua AU - Kawasaki, Ernest S AU - Popescu, Nicholas C AU - Weinstein, John AU - Goldstein, David AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Colon KW - Breast carcinoma KW - SiRNA KW - DNA topoisomerase KW - Breast KW - Genomics KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Genetic%2C+Genomic+and+Functional+Characterization+of+Topoisomerase+I+siRNA+Cell+Lines+Derived+from+Human+Breast+and+Colon+Carcinomas&rft.au=Miao%2C+Ze_Hong%3BPlayer%2C+Audrey%3BShankavaram%2C+Uma%3BWang%2C+Yong-Hong%3BLiao%2C+Zhi-Yong%3BZimonjic%2C+Drazen%3BZhang%2C+HongLiang%3BMeng%2C+Ling-Hua%3BKawasaki%2C+Ernest+S%3BPopescu%2C+Nicholas+C%3BWeinstein%2C+John%3BGoldstein%2C+David%3BPommier%2C+Yves&rft.aulast=Miao&rft.aufirst=Ze_Hong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 4-Nitroquinoline-1-Oxide Induces the Formation of Cellular Topoisomerase I-DNA Cleavage Complexes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39864099; 4185586 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Miao, Ze-Hong AU - Rao, V Ashutosh AU - Agama, Keli AU - Antony, Smitha AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Carcinogenesis KW - DNA repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39864099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=4-Nitroquinoline-1-Oxide+Induces+the+Formation+of+Cellular+Topoisomerase+I-DNA+Cleavage+Complexes&rft.au=Miao%2C+Ze-Hong%3BRao%2C+V+Ashutosh%3BAgama%2C+Keli%3BAntony%2C+Smitha%3BPommier%2C+Yves&rft.aulast=Miao&rft.aufirst=Ze-Hong&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Claudin 16 Overexpression and Ovarian Tumorigenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39862485; 4183121 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Agarwal, Rachana AU - Morin, Patrice J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumorigenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Claudin+16+Overexpression+and+Ovarian+Tumorigenesis&rft.au=Agarwal%2C+Rachana%3BMorin%2C+Patrice+J&rft.aulast=Agarwal&rft.aufirst=Rachana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gefitinib Effectiveness in an Head and Neck Squamous Cell Carcinoma In Vitro Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39862060; 4184145 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sebastian, Sinto AU - Azzariti, Amalia AU - Porcelli, Letizia AU - Simone, Grazia M AU - Tommasino, Massimo AU - Paradiso, Angelo Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Squamous cell carcinoma KW - Head and neck cancer KW - Gefitinib KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Gefitinib+Effectiveness+in+an+Head+and+Neck+Squamous+Cell+Carcinoma+In+Vitro+Model&rft.au=Sebastian%2C+Sinto%3BAzzariti%2C+Amalia%3BPorcelli%2C+Letizia%3BSimone%2C+Grazia+M%3BTommasino%2C+Massimo%3BParadiso%2C+Angelo&rft.aulast=Sebastian&rft.aufirst=Sinto&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Novel Chk2 Inhibitors T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39861728; 4185345 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jobson, Andrew G AU - Scudiero, Dominic AU - Currens, Michael AU - Shoemaker, Robert AU - Cardellina, John AU - Zhang, Hongliang AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39861728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+and+Characterization+of+Novel+Chk2+Inhibitors&rft.au=Jobson%2C+Andrew+G%3BScudiero%2C+Dominic%3BCurrens%2C+Michael%3BShoemaker%2C+Robert%3BCardellina%2C+John%3BZhang%2C+Hongliang%3BPommier%2C+Yves&rft.aulast=Jobson&rft.aufirst=Andrew&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Closing Remarks and Introduction of Mentors T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39859339; 4186552 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Johnson, Alfred C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Closing+Remarks+and+Introduction+of+Mentors&rft.au=Johnson%2C+Alfred+C&rft.aulast=Johnson&rft.aufirst=Alfred&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PAK3 is a cJun Transcriptional Target Gene Involved in cJun-Induced Anchorage-Independent Growth of Rat1a Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39856835; 4185070 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Donninger, Howard AU - Leaner, Virna D AU - Chick, Jeffrey F.B. AU - Birrer, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Transcription KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39856835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=PAK3+is+a+cJun+Transcriptional+Target+Gene+Involved+in+cJun-Induced+Anchorage-Independent+Growth+of+Rat1a+Cells&rft.au=Donninger%2C+Howard%3BLeaner%2C+Virna+D%3BChick%2C+Jeffrey+F.B.%3BBirrer%2C+Michael+J&rft.aulast=Donninger&rft.aufirst=Howard&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nonsense-Mediated Decay Microarray Analysis Identifies Potential Tumor Suppressor Genes in Neuroblastoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39855358; 4182612 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Song, Young K AU - Huusko, Pia AU - Bilke, Sven AU - Greer, Braden AU - Wei, Jun S AU - Chen, Qing-Rong AU - Khan, Javed Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Decay KW - Tumor suppressor genes KW - Neuroblastoma KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39855358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nonsense-Mediated+Decay+Microarray+Analysis+Identifies+Potential+Tumor+Suppressor+Genes+in+Neuroblastoma&rft.au=Song%2C+Young+K%3BHuusko%2C+Pia%3BBilke%2C+Sven%3BGreer%2C+Braden%3BWei%2C+Jun+S%3BChen%2C+Qing-Rong%3BKhan%2C+Javed&rft.aulast=Song&rft.aufirst=Young&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curcumin is a Potent Modulator of Multidrug Resistance-Linked ABC Drug Transporter ABCG2 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39851787; 4181959 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Shukla, Suneet AU - Chearwae, Wanida AU - Limtrakul, Pornngarm AU - Ambudkar, Suresh V Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Curcumin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39851787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Curcumin+is+a+Potent+Modulator+of+Multidrug+Resistance-Linked+ABC+Drug+Transporter+ABCG2&rft.au=Shukla%2C+Suneet%3BChearwae%2C+Wanida%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - What do I think you're doing? Action identification and mind attribution AN - 37744623; 3274970 AB - The authors examined how a perceiver's identification of a target person's actions covaries with attributions of mind to the target. The authors found in Study 1 that the attribution of intentionality and cognition to a target was associated with identifying the target's action in terms of high-level effects rather than low-level details. In Study 2, both action identification and mind attribution were greater for a liked target, and in Study 3, they were reduced for a target suffering misfortune. In Study 4, it was again found that action identification and mind attribution were greater for a liked target, but like that for the self or a liked other, positive actions were identified at higher levels than negative actions, with the reverse being true for disliked others. In Study 5, the authors found that instructing participants to adopt the target's perspective did not affect mind attribution but did lead to higher level identifications of the target's actions. Reprinted by permission of the American Psychological Association JF - Journal of personality and social psychology AU - Kozak, Megan N AU - Marsh, Abigail A AU - Wegner, Daniel M AD - Harvard University ; National Institute of Mental Health Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 543 EP - 555 VL - 90 IS - 4 SN - 0022-3514, 0022-3514 KW - Sociology KW - Action theory KW - Social psychology KW - Perception KW - Observation KW - Empirical research KW - Covariance KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37744623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=What+do+I+think+you%27re+doing%3F+Action+identification+and+mind+attribution&rft.au=Kozak%2C+Megan+N%3BMarsh%2C+Abigail+A%3BWegner%2C+Daniel+M&rft.aulast=Kozak&rft.aufirst=Megan&rft.date=2006-04-01&rft.volume=90&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2F0022-3514.90.4.543 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11901 10404; 549 12004 12008; 2449 10404; 9382; 2977 13249 10214 12224 971; 8829; 4200 10902 DO - http://dx.doi.org/10.1037/0022-3514.90.4.543 ER - TY - JOUR T1 - Perceived partner serostatus, attribution of responsibility for prevention of HIV transmission, and sexual risk behavior with 'main' partner among adults living with HIV AN - 36471676; 3340207 AB - Persons living with HIV (PLH) often attribute HIV status to sexual partners based on observable partner characteristics. The present study investigated the relationship of sexual behavior with most recent 'main' partner to that partner's perceived serostatus among 1,232 PLH interviewed in clinics and community agencies in Los Angeles, California. PLH who believed their most recent main partner to be HIV-negative more often identified partner appearance as a basis for their perceptions than those who believed their most recent main partner to be HIV-positive. PLH who perceived their most recent main partner as HIV-negative more likely to assume responsibility for partner protection and always to use condoms, and less likely to report recent unprotected vaginal or anal sex with that partner. Unprotected receptive anal intercourse with their most recent main partner was less common among African American, Latino, and White participants who believed that partner to be HIV-negative. Although PLH appear protective toward HIV-negative main partners, interventions to encourage valid methods of identifying partner serostatus are needed. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Hong, Daniel S AU - Goldstein, Risë B AU - Rotheram-Borus, Mary Jane AU - Wong, F Lennie AU - Gore-Felton, Cheryl AD - University of California ; Medical College of Wisconsin Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 150 EP - 162 VL - 18 IS - 2 SN - 0899-9546, 0899-9546 KW - Sociology KW - U.S.A. KW - California KW - Attitudes KW - Partners KW - Sexual behaviour KW - Responsibility KW - Ethnicity KW - Perception KW - Physical appearance KW - HIV KW - Sexually transmitted diseases KW - Judgement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36471676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Perceived+partner+serostatus%2C+attribution+of+responsibility+for+prevention+of+HIV+transmission%2C+and+sexual+risk+behavior+with+%27main%27+partner+among+adults+living+with+HIV&rft.au=Hong%2C+Daniel+S%3BGoldstein%2C+Ris%C3%AB+B%3BRotheram-Borus%2C+Mary+Jane%3BWong%2C+F+Lennie%3BGore-Felton%2C+Cheryl&rft.aulast=Hong&rft.aufirst=Daniel&rft.date=2006-04-01&rft.volume=18&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9382; 5703 3617 6220; 9234 7615; 7007 3322 6071 1542 11325 4551; 4435; 10970; 1378 10404; 9508; 11581 3617 6220; 11563 1025 1542 11325 6071; 72 433 293 14 ER - TY - JOUR T1 - Multidirectional chromosome painting reveals a remarkable syntenic homology between the greater galagos and the slow loris AN - 36439950; 3328227 AB - We report on the first reciprocal chromosome painting of lorisoids and humans. The chromosome painting showed a remarkable syntenic homology between Otolemur and Nycticebus. Eight derived syntenic associations of human segments are common to both Otolemur and Nycticebus, indicative of a considerable period of common evolution between the greater galago and the slow loris. Five additional Robertsonian translocations form the slow loris karyotype, while the remaining chromosomes are syntenically equivalent, although some differ in terms of centromere position and heterochromatin additions. Strikingly, the breakpoints of the human chromosomes found fragmented in these two species are apparently identical. Only fissions of homologs to human chromosomes 1 and 15 provide significant evidence of a cytogenetic link between Lemuriformes and Lorisiformes. The association of human chromosomes 7/16 in both lorisoids strongly suggests that this chromosome was present in the ancestral primate genome. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Stanyon, R AU - Dumas, F AU - Stone, G AU - Bigoni, F AD - National Cancer Institute-Frederick ; Università degli Studi di Palermo Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 349 EP - 360 VL - 68 IS - 4 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Biological anthropology KW - Phylogeny KW - Chromosomes KW - Primatology KW - Primate genetics KW - Evolutionary anthropology KW - DNA KW - Primates KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36439950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Multidirectional+chromosome+painting+reveals+a+remarkable+syntenic+homology+between+the+greater+galagos+and+the+slow+loris&rft.au=Stanyon%2C+R%3BDumas%2C+F%3BStone%2C+G%3BBigoni%2C+F&rft.aulast=Stanyon&rft.aufirst=R&rft.date=2006-04-01&rft.volume=68&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20229 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2257 5455 1678; 3254 5460 1615 8573 11325; 9504 4562; 4562; 10146 10148 10149 5460 1615 8573 11325; 1608 1077; 4563 1608 1077; 10148; 10149 DO - http://dx.doi.org/10.1002/ajp.20229 ER - TY - JOUR T1 - Data and safety monitoring in social behavioral intervention trials: the REACH II experience AN - 21334087; 10893825 AB - Background Psychosocial and behavioral interventions trials targeting a broad range of complex social and behavioral problems such as smoking, obesity and family caregiving have proliferated in the past 30 years. At the same time the use of Data and Safety Monitoring Boards (DSMBs) to monitor the progress and quality of intervention trials and the safety of study participants has increased substantially. Most of the existing literature and guidelines for safety monitoring and reporting of adverse events focuses on medical interventions. Consequently, there is little guidance for investigators conducting social and behavior trials.Purpose This paper summarizes how issues associated with safety monitoring and adverse event reporting were handled in the Resources for Enhancing Alzheimer's Caregiver Health (REACH II) program, a multi-site randomized clinical trial, funded by the National Institutes on Aging (NIA) and the National Institutes of Nursing Research (NINR), that tested the efficacy of a multicomponent social/behavioral intervention for caregivers of persons with Alzheimer's disease.Methods A task force was formed to define adverse events for the trial and protocols for reporting and resolving events that occurred. The task force conducted a review of existing policies and protocols for data and safety monitoring and adverse event reporting and identified potential risks particular to the study population. An informal survey regarding data and safety monitoring procedures with investigators on psychosocial intervention trials was also conducted.Results Two categories of events were defined for both caregivers and patients; adverse events and safety alerts. A distinction was also made between events detected at baseline assessment and those detected post-randomization. Standardized protocols were also developed for the reporting and resolution of events that occurred and training of study personnel. Results from the informal survey indicated wide variability in practices for data safety and monitoring across psychosocial intervention trials.Conclusions Overall, the REACH II experience demonstrates that existing guidelines regarding safety monitoring and adverse event reporting pose unique challenges for social/behavioral intervention trials. Challenges encountered in the REACH II program included defining and classifying adverse events, defining 'resolution' of adverse events and attributing causes for events that occurred. These challenges are highlighted and recommendations for addressing them in future studies are discussed. JF - Clinical Trials AU - Czaja, Sara J AU - Schulz, Richard AU - Belle, Steven H AU - Burgio, Louis D AU - Armstrong, Nell AU - Gitlin, Laura N AU - Coon, David W AU - Martindale-Adams, Jennifer AU - Klinger, Julie AU - Stahl, Sidney M AD - Behavioral and Social Research Program, National Institute on Aging/National Institutes of Health, Bethesda, MD, USA, sczaja@med.miami.edu Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 107 EP - 118 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 3 IS - 2 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts; Risk Abstracts KW - obesity KW - clinical trials KW - Smoking KW - guidelines KW - intervention KW - aging KW - Training KW - Reviews KW - Standards KW - Side effects KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21334087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Data+and+safety+monitoring+in+social+behavioral+intervention+trials%3A+the+REACH+II+experience&rft.au=Czaja%2C+Sara+J%3BSchulz%2C+Richard%3BBelle%2C+Steven+H%3BBurgio%2C+Louis+D%3BArmstrong%2C+Nell%3BGitlin%2C+Laura+N%3BCoon%2C+David+W%3BMartindale-Adams%2C+Jennifer%3BKlinger%2C+Julie%3BStahl%2C+Sidney+M&rft.aulast=Czaja&rft.aufirst=Sara&rft.date=2006-04-01&rft.volume=3&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1191%2F1740774506cn136oa LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Side effects; intervention; clinical trials; guidelines; Standards; Reviews; Training; obesity; aging; Smoking DO - http://dx.doi.org/10.1191/1740774506cn136oa ER - TY - JOUR T1 - The new drugs advent: clinical or economic outcomes? AN - 21294700; 6752026 JF - Annals of Oncology AU - De Maio, E AU - Perrone, F AU - Bisagni, G AU - Boni, C AD - Clinical Trials Unit, National Cancer Institute of Naples, Naples Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - ii88 EP - ii90 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 17 SN - 0923-7534, 0923-7534 KW - Biotechnology and Bioengineering Abstracts KW - Economics KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21294700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=The+new+drugs+advent%3A+clinical+or+economic+outcomes%3F&rft.au=De+Maio%2C+E%3BPerrone%2C+F%3BBisagni%2C+G%3BBoni%2C+C&rft.aulast=De+Maio&rft.aufirst=E&rft.date=2006-04-01&rft.volume=17&rft.issue=&rft.spage=ii88&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Economics; Drugs ER - TY - JOUR T1 - Critical Resources for Gene Therapy in Heart, Lung, and Blood Diseases Working Group AN - 21294487; 6838922 JF - Molecular Therapy AU - Woo, Savio LC AU - Skarlatos, Sonia I AU - Joyce, Mary M AU - Croxton, Thomas L AU - Qasba, Pankaj AD - Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA, skarlats@nhlbi.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 641 EP - 643 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 4 SN - 1525-0016, 1525-0016 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Gene therapy KW - Lung diseases KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21294487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Critical+Resources+for+Gene+Therapy+in+Heart%2C+Lung%2C+and+Blood+Diseases+Working+Group&rft.au=Woo%2C+Savio+LC%3BSkarlatos%2C+Sonia+I%3BJoyce%2C+Mary+M%3BCroxton%2C+Thomas+L%3BQasba%2C+Pankaj&rft.aulast=Woo&rft.aufirst=Savio&rft.date=2006-04-01&rft.volume=13&rft.issue=4&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1016%2Fj.ymthe.2005.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood; Gene therapy; Lung diseases DO - http://dx.doi.org/10.1016/j.ymthe.2005.12.007 ER - TY - JOUR T1 - Theoretical analysis of carbon-13 magnetization transfer for in vivo exchange between alpha -ketoglutarate and glutamate AN - 21063531; 8632129 AB - Many enzymes catalyze fast exchange between a small pool and a large pool in vivo. For example, aspartate aminotransferase catalyzes fast exchanges between -ketoglutarate and glutamate and between oxaloacetate and aspartate, which can be detected using in vivo13C MRS while saturating -carbons of the keto acids. Unlike in the traditional saturation transfer experiments studied using 31P MRS, the tricarboxylic acid cycle intermediates -ketoglutarate and oxaloacetate are below the detection limit of in vivo NMR. In this work, a theoretical analysis of the saturation transfer between -ketoglutarate and glutamate catalyzed by aspartate aminotransferase was presented to examine the requirements for complete saturation of the rapidly turning over -ketoglutarate pool without affecting the longitudinal magnetization of glutamate. The fast turnover of the small -ketoglutarate pool also allows a quasi-steady-state approximation of its dynamic longitudinal relaxation. The theoretical analysis provides a useful guide for designing experimental methods to characterize saturation transfer processes associated with fast turning over small pools in vivo. JF - NMR in Biomedicine AU - Shen, Jun AU - Xu, Su AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892, USA, shenj@intra.nimh.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 248 EP - 254 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 19 IS - 2 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Aspartate aminotransferase KW - Acids KW - Enzymes KW - N.M.R. KW - Glutamic acid KW - Tricarboxylic acid cycle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Theoretical+analysis+of+carbon-13+magnetization+transfer+for+in+vivo+exchange+between+alpha+-ketoglutarate+and+glutamate&rft.au=Shen%2C+Jun%3BXu%2C+Su&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2006-04-01&rft.volume=19&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Glutamic acid; N.M.R.; Aspartate aminotransferase; Tricarboxylic acid cycle; Enzymes; Acids DO - http://dx.doi.org/10.1002/nbm.1021 ER - TY - JOUR T1 - TRANSFUSION COMPLICATIONS: Streptococcus agalactiae sepsis after transfusion of a plateletpheresis concentrate: benefit of donor evaluation AN - 20870007; 6774873 AB - BACKGROUND:Bacterial contamination of platelet (PLT) components is an important cause of transfusion reactions. Recent efforts have focused on heightened surveillance to detect contamination before transfusion to limit recipient morbidity and mortality. Although identifying the cause of contamination is most often viewed in the context of recipient safety, this case illustrates the importance of a thorough evaluation on donor safety. CASE REPORT:A 68-year-old woman experienced a severe febrile reaction after a plateletpheresis transfusion. Blood cultures from the patient and from the plateletpheresis component were both positive for the presence of Streptococcus agalactiae. No abnormalities were identified on review of collection and processing records. The donor was asymptomatic and had a negative review of systems, a normal physical exam, normal laboratory values, and negative blood and urine cultures. One of three stool samples was positive for the presence of occult blood. Colonoscopy revealed a Dukes Stage B colonic adenocarcinoma. Fifteen months after surgical resection and adjuvant chemotherapy, the donor had no evidence of recurrent tumor. CONCLUSION:Identification of bacteria in blood components should trigger a comprehensive donor evaluation, particularly if donor bacteremia is suspected. Organisms that may be associated with an enteric source should prompt a thorough gastrointestinal evaluation. Because the primary reservoir of S. agalactiae in the human body is the gastrointestinal tract, and because no findings suggested an alternate portal of entry in our male donor, a gastrointestinal source was suspected. In this case, an evaluation for organism-specific pathology led to early identification of a potentially curable large bowel lesion. JF - Transfusion AU - Stevens, Wesley T AU - Bolan, Charles D AU - Oblitas, Jaime M AU - Stroncek, David F AU - Bennett, John E AU - Leitman, Susan F AD - Susan F. Leitman, Department of Transfusion Medicine, National Institutes of Health, Building 10, Room 1C711, MSC 1184, Bethesda, MD 20892-1184, sleitman@mail.cc.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 649 EP - 651 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 46 IS - 4 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts B: Bacteriology KW - Blood culture KW - Mortality KW - Contamination KW - Chemotherapy KW - Bacteremia KW - Tumors KW - Adjuvants KW - Transfusion KW - Morbidity KW - Sepsis KW - Urine KW - Streptococcus agalactiae KW - Reviews KW - Intestine KW - Platelets KW - Gastrointestinal tract KW - Adenocarcinoma KW - Feces KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20870007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=TRANSFUSION+COMPLICATIONS%3A+Streptococcus+agalactiae+sepsis+after+transfusion+of+a+plateletpheresis+concentrate%3A+benefit+of+donor+evaluation&rft.au=Stevens%2C+Wesley+T%3BBolan%2C+Charles+D%3BOblitas%2C+Jaime+M%3BStroncek%2C+David+F%3BBennett%2C+John+E%3BLeitman%2C+Susan+F&rft.aulast=Stevens&rft.aufirst=Wesley&rft.date=2006-04-01&rft.volume=46&rft.issue=4&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2006.00760.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - SuppNotes - References, 15. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Blood culture; Mortality; Contamination; Chemotherapy; Bacteremia; Adjuvants; Tumors; Transfusion; Morbidity; Sepsis; Urine; Reviews; Platelets; Intestine; Gastrointestinal tract; Feces; Adenocarcinoma; Streptococcus agalactiae DO - http://dx.doi.org/10.1111/j.1537-2995.2006.00760.x ER - TY - JOUR T1 - Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI AN - 20857398; 8368082 AB - In mammalian hearts the capillaries are closely aligned with the muscle fibers. We report our observation of a main-field direction-dependent contrast in MR spin-echo (SE) images of the heart in the presence of Ferumoxtran-10, an intravascular iron-oxide nanoparticle contrast agent (CA). We describe a novel MRI method for mapping the preferential orientation of capillaries in the myocardial wall. The eigenvector corresponding to the minimum eigen value of the R2 relaxation rate tensor is consistent with the expected orientation of the capillary network. Preliminary results also demonstrate the feasibility of this method for in vivo application to rodent imaging. Published. JF - Magnetic Resonance in Medicine AU - Vignaud, Alexandre AU - Rodriguez, Ignacio AU - Ennis, Daniel B AU - Desilva, Ranil AU - Kellman, Peter AU - Taylor, Joni AU - Bennett, Eric AU - Wen, Han AD - Laboratory of Cardiac Energetics, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, wenh@nhlbi.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 725 EP - 730 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Magnetic resonance imaging KW - Muscles KW - Contrast media KW - Cardiac muscle KW - N.M.R. KW - Mapping KW - nanoparticles KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Detection+of+myocardial+capillary+orientation+with+intravascular+iron-oxide+nanoparticles+in+spin-echo+MRI&rft.au=Vignaud%2C+Alexandre%3BRodriguez%2C+Ignacio%3BEnnis%2C+Daniel+B%3BDesilva%2C+Ranil%3BKellman%2C+Peter%3BTaylor%2C+Joni%3BBennett%2C+Eric%3BWen%2C+Han&rft.aulast=Vignaud&rft.aufirst=Alexandre&rft.date=2006-04-01&rft.volume=55&rft.issue=4&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20827 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; nanoparticles; Cardiac muscle; Mapping; N.M.R.; Contrast media; Heart; Muscles DO - http://dx.doi.org/10.1002/mrm.20827 ER - TY - JOUR T1 - Investigation of anomalous estimates of tensor-derived quantities in diffusion tensor imaging AN - 20855389; 8368107 AB - The diffusion tensor is typically assumed to be positive definite. However, noise in the measurements may cause the eigenvalues of the tensor estimate to be negative, thereby violating this assumption. Negative eigenvalues in diffusion tensor imaging (DTI) data occur predominately in regions of high anisotropy and may cause the fractional anisotropy (FA) to exceed unity. Two constrained least squares methods for eliminating negative eigenvalues are explored. These methods, the constrained linear least squares method (CLLS) and the constrained nonlinear least squares method (CNLS), are compared with other commonly used algebraic constrained methods. The CLLS tensor estimator can be shown to be equivalent to the linear least squares (LLS) tensor estimator when the LLS tensor estimate is positive definite. Similarly, the CNLS tensor estimator can be shown to be equivalent to the nonlinear least squares (NLS) tensor estimator when the NLS tensor estimate is positive definite. The constrained least squares methods for eliminating negative eigenvalues are evaluated with both simulations and in vivo human brain DTI data. Simulation results show that the CNLS method is, in terms of mean squared error for estimating trace and FA, the most effective method for correcting negative eigenvalues. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Koay, Cheng Guan AU - Carew, John D AU - Alexander, Andrew L AU - Basser, Peter J AU - Meyerand, M Elizabeth AD - Department of Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA, guankoac@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 930 EP - 936 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Anisotropy KW - Magnetic resonance imaging KW - Brain KW - Chronic lymphatic leukemia KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Investigation+of+anomalous+estimates+of+tensor-derived+quantities+in+diffusion+tensor+imaging&rft.au=Koay%2C+Cheng+Guan%3BCarew%2C+John+D%3BAlexander%2C+Andrew+L%3BBasser%2C+Peter+J%3BMeyerand%2C+M+Elizabeth&rft.aulast=Koay&rft.aufirst=Cheng&rft.date=2006-04-01&rft.volume=55&rft.issue=4&rft.spage=930&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20832 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Anisotropy; Data processing; Chronic lymphatic leukemia; Brain DO - http://dx.doi.org/10.1002/mrm.20832 ER - TY - JOUR T1 - A Novel Bacterium Associated with Lymphadenitis in a Patient with Chronic Granulomatous Disease AN - 20722167; 6933198 AB - Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life- threatening infections. We identified a novel gram-negative rod in excised lymph nodes from a patient with CGD. Gram-negative rods grew on charcoal-yeast extract, but conventional tests could not identify it. The best 50 matches of the 16S rRNA (using BLAST) were all members of the family Acetobacteraceae, with the closest match being Gluconobacter sacchari. Patient serum showed specific band recognition in whole lysate immunoblot. We used mouse models of CGD to determine whether this organism was a genuine CGD pathogen. Intraperitoneal injection of gp91 super(phox) super(-/-) (X-linked) and p47 super(phox -/-) (autosomal recessive) mice with this bacterium led to larger burdens of organism recovered from knockout compared with wild-type mice. Knockout mouse lymph nodes had histopathology that was similar to that seen in our patient. We recovered organisms with 16S rRNA sequence identical to the patient's original isolate from the infected mice. We identified a novel gram-negative rod from a patient with CGD. To confirm its pathogenicity, we demonstrated specific immune reaction by high titer antibody, showed that it was able to cause similar disease when introduced into CGD, but not wild-type mice, and we recovered the same organism from pathologic lesions in these mice. Therefore, we have fulfilled Koch's postulates for a new pathogen. This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. Polyphasic taxonomic analysis shows this organism to be a new genus and species for which we propose the name Granulobacter bethesdensis. JF - PLoS Pathogens AU - Greenberg, David E AU - Ding, Li AU - Zelazny, Adrian M AU - Stock, Frida AU - Wong, Alexandra AU - Anderson, Victoria L AU - Miller, Georgina AU - Kleiner, David E AU - Tenorio, Allan R AU - Brinster, Lauren AU - Dorward, David W AU - Murray, Patrick R AU - Holland, Steven M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, smh@nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 2 IS - 4 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Hereditary diseases KW - X chromosome KW - Animal models KW - Metabolites KW - Pathogens KW - Lymph nodes KW - Oxygen KW - Antibodies KW - Lymphadenitis KW - Pathogenicity KW - Phagocytes KW - Chronic infection KW - Gluconobacter KW - Recurrent infection KW - NAD(P)H oxidase KW - Chronic granulomatous disease KW - rRNA 16S KW - Rods KW - New species KW - K 03410:Animal Diseases KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=A+Novel+Bacterium+Associated+with+Lymphadenitis+in+a+Patient+with+Chronic+Granulomatous+Disease&rft.au=Greenberg%2C+David+E%3BDing%2C+Li%3BZelazny%2C+Adrian+M%3BStock%2C+Frida%3BWong%2C+Alexandra%3BAnderson%2C+Victoria+L%3BMiller%2C+Georgina%3BKleiner%2C+David+E%3BTenorio%2C+Allan+R%3BBrinster%2C+Lauren%3BDorward%2C+David+W%3BMurray%2C+Patrick+R%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2006-04-01&rft.volume=2&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.0020028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hereditary diseases; X chromosome; Animal models; Metabolites; Pathogens; Lymph nodes; Oxygen; Lymphadenitis; Antibodies; Pathogenicity; Phagocytes; Chronic infection; NAD(P)H oxidase; Recurrent infection; Chronic granulomatous disease; rRNA 16S; Rods; New species; Bacteria; Gluconobacter DO - http://dx.doi.org/10.1371/journal.ppat.0020028 ER - TY - JOUR T1 - COX-2 Polymorphism, Use of Nonsteroidal Anti-Inflammatory Drugs, and Risk of Colon Cancer in African Americans (United States) AN - 20721225; 7023313 AB - Introduction: The inducible Cyclooxygenase (COX)-2 enzyme plays an important role in inflammation and carcinogenesis. Recent reports suggest that single nucleotide polymorphisms (SNPs) in the COX-2 gene may alter enzyme function and in turn modify an individual's risk of colon cancer. We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina. Methods: We used unconditional logistic regression models to determine the odds ratios (ORs) for genotype and risk of colon cancer. Results: We observed a non-statistically significant inverse association between any Ala COX-2 genotype and risk of colon cancer (OR = 0.62, 95% CI: 0.33, 1.16) among African Americans. The inverse association was present among non-regular NSAID users, use less than or equal to 3 times/week, (OR = 0.66; 95% CI: 0.32, 1.37) and regular NSAID users, use greater than or equal to 3 times/week for greater than or equal to 3 months, (OR = 0.41; 95% CI: 0.11, 1.54). Conclusions: Our results suggest that the COX-2 Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the COX-2 Val511Ala SNP may contribute to a reduced risk of colon cancer among African Americans. JF - Cancer Causes & Control AU - Sansbury, Leah B AU - Millikan, Robert C AU - Schroeder, Jane C AU - North, Kari E AU - Moorman, Patricia G AU - Keku, Temitope O AU - Cotret, Allan Rene' AU - Player, Jon AU - Sandler, Robert S AD - National Cancer Institute, NIH, DHHS, 6116 Executive Boulevard, MSC 8325, Suite 702, Room 7207, Bethesda, MD, 20892-8325, USA, sansburl@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 257 EP - 266 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 3 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - USA, North Carolina KW - risk reduction KW - antiinflammatory agents KW - Carcinogenesis KW - Africa KW - Enzymes KW - Genotypes KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=COX-2+Polymorphism%2C+Use+of+Nonsteroidal+Anti-Inflammatory+Drugs%2C+and+Risk+of+Colon+Cancer+in+African+Americans+%28United+States%29&rft.au=Sansbury%2C+Leah+B%3BMillikan%2C+Robert+C%3BSchroeder%2C+Jane+C%3BNorth%2C+Kari+E%3BMoorman%2C+Patricia+G%3BKeku%2C+Temitope+O%3BCotret%2C+Allan+Rene%27%3BPlayer%2C+Jon%3BSandler%2C+Robert+S&rft.aulast=Sansbury&rft.aufirst=Leah&rft.date=2006-04-01&rft.volume=17&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-005-0417-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; antiinflammatory agents; Carcinogenesis; Enzymes; Genotypes; Ethnic groups; Cancer; USA, North Carolina; Africa DO - http://dx.doi.org/10.1007/s10552-005-0417-0 ER - TY - JOUR T1 - Quaternary Structure and Cleavage Specificity of a Poxvirus Holliday Junction Resolvase AN - 20717430; 6810711 AB - Recently, poxviruses were found to encode a protein with signature motifs present in the RuvC family of Holliday junction (HJ) resolvases, which have a key role in homologous recombination in bacteria. The vaccinia virus homolog A22 specifically cleaved synthetic HJ DNA in vitro and was required for the in vivo resolution of viral DNA concatemers into unit-length genomes with hairpin telomeres. It was of interest to further characterize a poxvirus resolvase in view of the low sequence similarity with RuvC, the absence of virus-encoded RuvA and RuvB to interact with, and the different functions of the viral and bacterial resolvases. Because purified A22 aggregated severely, studies were carried out with maltose-binding protein fused to A22 as well as to RuvC. Using gel filtration, chemical cross-linking, analytical ultracentrifugation, and light scattering, we demonstrated that A22 and RuvC are homodimers in solution. Furthermore, the dimeric form of the resolvase associated with HJ DNA, presumably facilitating the symmetrical cleavage of such structures. Like RuvC, A22 symmetrically cleaved fixed HJ junctions as well as junctions allowing strand mobility. Unlike RuvC and other members of the family, however, the poxvirus enzyme exhibited little cleavage sequence specificity. Structural and enzymatic similarities of poxvirus, bacterial, and fungal mitochondrial HJ resolvases are consistent with their predicted evolutionary relationship based on sequence analysis. The absence of a homologous resolvase in mammalian cells makes these microbial enzymes excellent potential therapeutic targets. JF - Journal of Biological Chemistry AU - Garcia, Alonzo D AU - Otero, Joel AU - Lebowitz, Jacob AU - Schuck, Peter AU - Moss, Bernard AD - Laboratory of Viral Diseases, NIAID and the Division of Bioengineering and Physical Science, Office of Research Services, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 11618 EP - 11626 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 17 SN - 0021-9258, 0021-9258 KW - RuvA protein KW - RuvB protein KW - RuvC protein KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Holliday junctions KW - Mobility KW - Light scattering KW - Enzymes KW - Mitochondria KW - Quaternary structure KW - Ultracentrifugation KW - Protein structure KW - Telomeres KW - Filtration KW - Vaccinia virus KW - Mammalian cells KW - Poxvirus KW - DNA KW - homologous recombination KW - maltose-binding protein KW - Evolution KW - Resolvase KW - J 02410:Animal Diseases KW - K 03410:Animal Diseases KW - N 14835:Protein-Nucleic Acids Association KW - V 22031:Viral nucleic acids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20717430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Quaternary+Structure+and+Cleavage+Specificity+of+a+Poxvirus+Holliday+Junction+Resolvase&rft.au=Garcia%2C+Alonzo+D%3BOtero%2C+Joel%3BLebowitz%2C+Jacob%3BSchuck%2C+Peter%3BMoss%2C+Bernard&rft.aulast=Garcia&rft.aufirst=Alonzo&rft.date=2006-04-01&rft.volume=281&rft.issue=17&rft.spage=11618&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Holliday junctions; Mobility; Light scattering; Mitochondria; Enzymes; Quaternary structure; Ultracentrifugation; Protein structure; Telomeres; Filtration; Mammalian cells; DNA; maltose-binding protein; homologous recombination; Evolution; Resolvase; Vaccinia virus; Poxvirus ER - TY - JOUR T1 - Staphylococcus quorum sensing in biofilm formation and infection AN - 20622795; 8210858 AB - Cell population density-dependent regulation of gene expression is an important determinant of bacterial pathogenesis. Staphylococci have two quorum-sensing (QS) systems. The accessory gene regulator (agr) is genus specific and uses a post-translationally modified peptide as an autoinducing signal. In the pathogens Staphylococcus aureus and Staphylococcus epidermidis, agr controls the expression of a series of toxins and virulence factors and the interaction with the innate immune system. However, the role of agr during infection is controversial. A possible second QS system of staphylococci, luxS, is found in a variety of Gram-positive and Gram-negative bacteria. Importantly, unlike many QS systems described in Gram-negative bacteria, agr and luxS of staphylococci reduce rather than induce biofilm formation and virulence during biofilm-associated infection. agr enhances biofilm detachment by up-regulation of the expression of detergent-like peptides, whereas luxS reduces cell-to-cell adhesion by down-regulating expression of biofilm exopolysaccharide. Significant QS activity in staphylococci is observed for actively growing cells at a high cell density, such as during the initial stages of an infection and under optimal environmental conditions. In contrast, the metabolically quiescent biofilm mode of growth appears to be characterized by an overall low activity of the staphylococcal QS systems. It remains to be shown whether QS control in staphylococci represents a promising target for the development of novel antibacterial agents. JF - International Journal of Medical Microbiology AU - Kong, Kok-Fai AU - Vuong, Cuong AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 903 S 4th Street, Hamilton, MT 59840, USA, MOtto@niaid.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 133 EP - 139 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 296 IS - 2-3 SN - 1438-4221, 1438-4221 KW - Microbiology Abstracts B: Bacteriology; Chemoreception Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20622795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Medical+Microbiology&rft.atitle=Staphylococcus+quorum+sensing+in+biofilm+formation+and+infection&rft.au=Kong%2C+Kok-Fai%3BVuong%2C+Cuong%3BOtto%2C+Michael&rft.aulast=Kong&rft.aufirst=Kok-Fai&rft.date=2006-04-01&rft.volume=296&rft.issue=2-3&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Medical+Microbiology&rft.issn=14384221&rft_id=info:doi/10.1016%2Fj.ijmm.2006.01.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.ijmm.2006.01.042 ER - TY - JOUR T1 - An analysis of the integration between articular cartilage and nondegradable hydrogel using magnetic resonance imaging AN - 20559166; 8027084 AB - A hydrogel is a highly hydrated polymer gel suitable for use as a scaffold for tissue engineering. One important application is to the repair of cartilage defects due to injury or osteoarthritis. Integration of the hydrogel with surrounding tissue is critical for the long-term functionality of the implant; however direct visualization of integration is difficult and invasive. Accordingly, we used MRI to noninvasively investigate the integration of hydrogel in cartilage. Two integration methods were assessed: (1) cartilage-initiated and (2) chemical, using chondroitin sulphate-methacrylate-aldehyde (CS-MA-ald) as an adhesive. These were compared to a control group, that is, standard, nonintegrated hydrogel photopolymerization. Spatial variation of the transverse relaxation time, T2, across the transition region was used to determine the effectiveness of integration. In the CS-MA-ald group only, two interfaces were found. This provides evidence of an intermediate adhesive layer between hydrogel and cartilage. Second, the thickness of the transition region between hydrogel to cartilage in the CS-MA-ald group was 1.32 mm as compared to 1.20 mm and 1.17 mm in the tissue-initiated and nonintegrated groups, respectively. We interpret this as a more gradual transition region of hydrogel to cartilage and hence a greater degree of integration when an adhesive layer is present. JF - Journal of Biomedical Materials Research Part B AU - Ramaswamy, Sharan AU - Wang, Dong-An AU - Fishbein, Kenneth W AU - Elisseeff, Jennifer H AU - Spencer, Richard G AD - National Institute on Aging, National Institutes of Health, Laboratory of Clinical Investigation, Gerontology Research Center, Room 4D-08, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, spencer@helix.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 144 EP - 148 PB - John Wiley & Sons, Inc. VL - 77B IS - 1 SN - 1552-4973, 1552-4973 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Cartilage diseases KW - Injuries KW - Osteoarthritis KW - Magnetic resonance imaging KW - Tissue engineering KW - scaffolds KW - Integration KW - spatial variations KW - hydrogels KW - Cartilage (articular) KW - Adhesives KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research+Part+B&rft.atitle=An+analysis+of+the+integration+between+articular+cartilage+and+nondegradable+hydrogel+using+magnetic+resonance+imaging&rft.au=Ramaswamy%2C+Sharan%3BWang%2C+Dong-An%3BFishbein%2C+Kenneth+W%3BElisseeff%2C+Jennifer+H%3BSpencer%2C+Richard+G&rft.aulast=Ramaswamy&rft.aufirst=Sharan&rft.date=2006-04-01&rft.volume=77B&rft.issue=1&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research+Part+B&rft.issn=15524973&rft_id=info:doi/10.1002%2Fjbm.b.30404 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - hydrogels; Integration; Cartilage diseases; Adhesives; Magnetic resonance imaging; Cartilage (articular); Tissue engineering; Osteoarthritis; spatial variations; scaffolds; Injuries DO - http://dx.doi.org/10.1002/jbm.b.30404 ER - TY - JOUR T1 - The Role of Functional Neuroimaging in Pediatric Brain Injury AN - 20239447; 6749681 AB - The aim of this article is to review empirical studies published in the last 10 years that used various functional neuroimaging techniques to assess pediatric patients with brain injury. Overall, these studies have demonstrated the ability of functional neuroimaging to offer unique information concerning the diagnosis, clinical outcome, and recovery mechanisms after pediatric brain injury. Future research using functional neuroimaging is recommended to better understand the functional reorganization and neurodevelopmental consequences resulting from brain injury. Such research might allow clinicians to design tailored early-intervention and rehabilitation programs to maximize the recovery process for pediatric patients. Limitations and advantages associated with the use of functional neuroimaging in pediatric populations are discussed. JF - Pediatrics AU - Munson, Suzanne AU - Schroth, Elizabeth AU - Ernst, Monique AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1372 EP - 1381 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 4 SN - 0031-4005, 0031-4005 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Brain injury KW - Rehabilitation KW - Pediatrics KW - N3 11027:Neurology & neuropathology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=The+Role+of+Functional+Neuroimaging+in+Pediatric+Brain+Injury&rft.au=Munson%2C+Suzanne%3BSchroth%2C+Elizabeth%3BErnst%2C+Monique&rft.aulast=Munson&rft.aufirst=Suzanne&rft.date=2006-04-01&rft.volume=117&rft.issue=4&rft.spage=1372&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Brain injury; Rehabilitation; Pediatrics ER - TY - JOUR T1 - Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium AN - 20225660; 6799838 AB - Scytovirin (SVN) is a novel anti-human immunodeficiency virus (HIV) protein isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein consists of a single 95-amino acid chain with significant internal sequence duplication and 10 cysteines forming five intrachain disulfide bonds. A synthetic gene that encodes scytovirin was constructed, and expressed in Escherichia coli, with thioredoxin (TRX) fused to its N-terminus (TRX-SVN). Most of the expressed protein was in soluble form, which was purified by a polyhistidine tag affinity purification step. SVN was then cleaved from TRX with enterokinase and separated from the TRX partner by C18 reversed-phase HPLC. This production method has proven superior to earlier synthetic attempts and recombinant procedures using a standard expression system. The current system resulted in yields of 5-10 mg/L of purified SVN for structural studies and for preclinical development of SVN as a topical microbicide for HIV prophylaxis. JF - Protein Expression and Purification AU - Xiong, C AU - O'Keefe, B R AU - Botos, I AU - Wlodawer, A AU - McMahon, J B AD - Molecular Targets Development Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 233 EP - 239 VL - 46 IS - 2 SN - 1046-5928, 1046-5928 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - High-performance liquid chromatography KW - Thioredoxin KW - Pharmacology KW - Disulfide bonds KW - Phytoplankton KW - Cell culture KW - Scytonema KW - Scytonema varium KW - protein purification KW - polyhistidine KW - N-Terminus KW - Recombinants KW - Gene expression KW - Cyanobacteria KW - Human immunodeficiency virus KW - Cysteine KW - Aquatic drugs KW - Escherichia coli KW - Prophylaxis KW - Proteins KW - Cyanophyta KW - microbicides KW - J 02310:Genetics & Taxonomy KW - W 30925:Genetic Engineering KW - K 03330:Biochemistry KW - V 22002:AIDS: Molecular and in vitro aspects KW - Q1 08625:Non-edible products KW - Q4 27380:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20225660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Overexpression+and+purification+of+scytovirin%2C+a+potent%2C+novel+anti-HIV+protein+from+the+cultured+cyanobacterium+Scytonema+varium&rft.au=Xiong%2C+C%3BO%27Keefe%2C+B+R%3BBotos%2C+I%3BWlodawer%2C+A%3BMcMahon%2C+J+B&rft.aulast=Xiong&rft.aufirst=C&rft.date=2006-04-01&rft.volume=46&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2005.09.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Recombinants; Pharmacology; Aquatic drugs; Phytoplankton; Proteins; Cell culture; Thioredoxin; High-performance liquid chromatography; Cysteine; Disulfide bonds; Prophylaxis; protein purification; polyhistidine; microbicides; N-Terminus; Cyanobacteria; Human immunodeficiency virus; Escherichia coli; Scytonema varium; Scytonema; Cyanophyta DO - http://dx.doi.org/10.1016/j.pep.2005.09.019 ER - TY - JOUR T1 - Genetic Diversity of the Q Fever Agent, Coxiella burnetii, Assessed by Microarray-Based Whole-Genome Comparisons AN - 20076111; 6747341 AB - Coxiella burnetii, a gram-negative obligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterrorism. Distinct genomic groups of C. burnetii are revealed by restriction fragment-length polymorphisms (RFLP). Here we comprehensively define the genetic diversity of C. burnetii by hybridizing the genomes of 20 RFLP-grouped and four ungrouped isolates from disparate sources to a high-density custom Affymetrix GeneChip containing all open reading frames (ORFs) of the Nine Mile phase I (NMI) reference isolate. We confirmed the relatedness of RFLP-grouped isolates and showed that two ungrouped isolates represent distinct genomic groups. Isolates contained up to 20 genomic polymorphisms consisting of 1 to 18 ORFs each. These were mostly complete ORF deletions, although partial deletions, point mutations, and insertions were also identified. A total of 139 chromosomal and plasmid ORFs were polymorphic among all C. burnetii isolates, representing ca. 7% of the NMI coding capacity. Approximately 67% of all deleted ORFs were hypothetical, while 9% were annotated in NMI as nonfunctional (e.g., frameshifted). The remaining deleted ORFs were associated with diverse cellular functions. The only deletions associated with isogenic NMI variants of attenuated virulence were previously described large deletions containing genes involved in lipopolysaccharide (LPS) biosynthesis, suggesting that these polymorphisms alone are responsible for the lower virulence of these variants. Interestingly, a variant of the Australia QD isolate producing truncated LPS had no detectable deletions, indicating LPS truncation can occur via small genetic changes. Our results provide new insight into the genetic diversity and virulence potential of Coxiella species. JF - Journal of Bacteriology AU - Beare, Paul A AU - Samuel, James E AU - Howe, Dale AU - Virtaneva, Kimmo AU - Porcella, Stephen F AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites. Laboratory of Persistent Viral Diseases. Genomics Core Facility, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840. Department of Medical Microbiology and Immunology, Texas A&M University System, Health Science Center, College Station, Texas 77843 Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 2309 EP - 2324 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 7 SN - 0021-9193, 0021-9193 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - bioterrorism KW - Gene polymorphism KW - Point mutation KW - Genetic diversity KW - Plasmids KW - double prime Q fever KW - Virulence KW - Genetic relationship KW - Coxiella burnetii KW - Gene deletion KW - Insertion KW - Gram-negative bacteria KW - Lipopolysaccharides KW - genomics KW - Genetic structure KW - Open reading frames KW - G 07320:Bacterial genetics KW - W 30930:Agricultural Applications KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20076111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genetic+Diversity+of+the+Q+Fever+Agent%2C+Coxiella+burnetii%2C+Assessed+by+Microarray-Based+Whole-Genome+Comparisons&rft.au=Beare%2C+Paul+A%3BSamuel%2C+James+E%3BHowe%2C+Dale%3BVirtaneva%2C+Kimmo%3BPorcella%2C+Stephen+F%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2006-04-01&rft.volume=188&rft.issue=7&rft.spage=2309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; bioterrorism; Gene polymorphism; Point mutation; Genetic diversity; Plasmids; double prime Q fever; Genetic relationship; Virulence; Gene deletion; Insertion; Gram-negative bacteria; Lipopolysaccharides; genomics; Genetic structure; Open reading frames; Coxiella burnetii ER - TY - JOUR T1 - Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans AN - 19991053; 7475562 AB - To define gene expression profiles that occur during the initial activation of human innate immunity, we administered intravenous endotoxin (n = 8) or saline (n = 4) to healthy subjects and hybridized RNA from blood mononuclear cells (0, 0.5, 6, 24, 168 h) or whole blood (0, 3, 6, 24, 168 h) to oligonucleotide probe arrays. The greatest change in mononuclear cell gene expression occurred at 6 h (439 induced and 428 repressed genes, 1% false discovery rate, and 50% fold change) including increased expression of genes associated with pathogen recognition molecules and signaling cascades linked to receptors associated with cell mobility and activation. Induced defense response genes included cytokines, chemokines, and their respective receptors, acute-phase transcription factors, proteases, arachidonate metabolites, and oxidases. Repressed defense response genes included those associated with co-stimulatory molecules, T and cytotoxic lymphocytes, natural killer (NK) cells, and protein synthesis. Gene expression profiles of whole blood had similar biological themes. Over 100 genes not typically associated with acute inflammation were differentially regulated after endotoxin. By 24 h, gene expression had returned to baseline values. Thus the inflammatory response of circulating leukocytes to endotoxin in humans is characterized by a rapid amplification and subsidence of gene expression. These results indicate that a single intravascular exposure to endotoxin produces a large but temporally short perturbation of the blood transcriptome. JF - Physiological Genomics AU - Talwar, S AU - Munson, P J AU - Barb, J AU - Fiuza, C AU - Cintron AU - Logan, C AU - Tropea, M AU - Khan, S AU - Reda, D AU - Shelhamer, J H AU - Danner, R L AU - Suffredini, A F AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 203 EP - 215 VL - 25 IS - 2 SN - 1094-8341, 1094-8341 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts KW - Endotoxins KW - Chemokines KW - Mobility KW - DNA probes KW - double prime H gene KW - Metabolites KW - Lymphocytes KW - H gene KW - Oligonucleotides KW - Cell activation KW - Gene expression KW - Subsidence KW - Lymphocytes T KW - Cytokines KW - Proteinase KW - Leukocytes (mononuclear) KW - Intravenous administration KW - Protein biosynthesis KW - Natural killer cells KW - Peripheral blood KW - Pathogens KW - Immunity KW - Inflammation KW - Cytotoxicity KW - RNA KW - Transcription factors KW - Signal transduction KW - A 01490:Miscellaneous KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19991053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+Genomics&rft.atitle=Gene+expression+profiles+of+peripheral+blood+leukocytes+after+endotoxin+challenge+in+humans&rft.au=Talwar%2C+S%3BMunson%2C+P+J%3BBarb%2C+J%3BFiuza%2C+C%3BCintron%3BLogan%2C+C%3BTropea%2C+M%3BKhan%2C+S%3BReda%2C+D%3BShelhamer%2C+J+H%3BDanner%2C+R+L%3BSuffredini%2C+A+F&rft.aulast=Talwar&rft.aufirst=S&rft.date=2006-04-01&rft.volume=25&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Physiological+Genomics&rft.issn=10948341&rft_id=info:doi/10.1152%2Fphysiolgenomics.00192.2005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endotoxins; Chemokines; Mobility; double prime H gene; DNA probes; Metabolites; H gene; Lymphocytes; Oligonucleotides; Cell activation; Gene expression; Subsidence; Lymphocytes T; Cytokines; Proteinase; Leukocytes (mononuclear); Intravenous administration; Protein biosynthesis; Natural killer cells; Peripheral blood; Immunity; Pathogens; Inflammation; Cytotoxicity; RNA; Transcription factors; Signal transduction DO - http://dx.doi.org/10.1152/physiolgenomics.00192.2005 ER - TY - JOUR T1 - Candida glabrata PDR1, a Transcriptional Regulator of a Pleiotropic Drug Resistance Network, Mediates Azole Resistance in Clinical Isolates and Petite Mutants AN - 19970502; 6750076 AB - Candida glabrata, a yeast with intrinsically low susceptibility to azoles, frequently develops increased azole resistance during prolonged treatment. Transposon mutagenesis revealed that disruption of CgPDR1 resulted in an 8- to 16-fold increase in fluconazole susceptibility of C. glabrata. CgPDR1 is a homolog of Saccharomyces cerevisiae PDR1, which encodes a transcriptional regulator of multidrug transporters. Northern blot analyses indicated that CgPDR1 regulated both constitutive and drug-induced expression of CgCDR1, a multidrug transporter gene. In agreement with the Northern analysis, the Cgpdr1 mutant had increased rhodamine accumulation, in contrast to the decreased accumulation in the CgPDR1-overexpressing strain. Northern analyses also indicated the importance of CgPDR1 in fluconazole resistance arising during therapy. Two clinically resistant isolates had higher expression of CgPDR1 and CgCDR1 compared to their paired susceptible isolates. Integrative transformation of CgPDR1 from the two resistant isolates converted the Cgpdr1 mutant into azole-resistant strains with upregulated CgPDR1 expression. Two different amino acid substitutions, W297S in one isolate and F575L in the other, accounted for the upregulated CgPDR1 expression and the resistance. Finally, CgPDR1 was shown to be required for the azole resistance due to mitochondrial deficiency. Thus, CgPDR1 encodes a transcriptional regulator of a pleiotropic drug resistance network and contributes to the azole resistance of clinical isolates and petite mutants. JF - Antimicrobial Agents & Chemotherapy AU - Tsai, Huei-Fung AU - Krol, Anna A AU - Sarti, Kelly E AU - Bennett, John E AD - Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1384 EP - 1392 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 4 SN - 0066-4804, 0066-4804 KW - budding yeast KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Clinical isolates KW - Transformation KW - Amino acid substitution KW - Drug resistance KW - Candida glabrata KW - Transcription KW - Mitochondria KW - Saccharomyces cerevisiae KW - Antimicrobial agents KW - fluconazole KW - transposon mutagenesis KW - rhodamine KW - azoles KW - Petite mutant KW - A 01340:Antibiotics & Antimicrobials KW - K 03087:Fungi: human KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19970502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Candida+glabrata+PDR1%2C+a+Transcriptional+Regulator+of+a+Pleiotropic+Drug+Resistance+Network%2C+Mediates+Azole+Resistance+in+Clinical+Isolates+and+Petite+Mutants&rft.au=Tsai%2C+Huei-Fung%3BKrol%2C+Anna+A%3BSarti%2C+Kelly+E%3BBennett%2C+John+E&rft.aulast=Tsai&rft.aufirst=Huei-Fung&rft.date=2006-04-01&rft.volume=50&rft.issue=4&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Clinical isolates; Amino acid substitution; fluconazole; transposon mutagenesis; Drug resistance; Mitochondria; Transcription; rhodamine; azoles; Antimicrobial agents; Petite mutant; Candida glabrata; Saccharomyces cerevisiae ER - TY - JOUR T1 - High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India AN - 19966738; 6753502 AB - BACKGROUND: Recent syphilis outbreaks have raised concern regarding the potential enhancement of HIV transmission. The incidence of syphilis and its association with HIV-1 infection rates among a cohort of sexually transmitted infection (STI) clinic attendees was investigated. METHODS: 2732 HIV-1 seronegative patients attending three STI and one gynaecology clinic, were enrolled from 1993-2000 in an ongoing prospective cohort study of acute HIV-1 infection in Pune, India. At screening and quarterly follow up visits, participants underwent HIV-1 risk reduction counselling, risk behaviour assessment and HIV/STI screening that included testing for serological evidence of syphilis by RPR with TPHA confirmation. Patients with genital ulcers were screened with dark field microscopy. RESULTS: Among 2324 participants who were HIV-1 and RPR seronegative at baseline, 172 participants were found to have clinical or laboratory evidence of syphilis during follow up (5.4 per 100 person years, 95% CI 4.8 to 6.5 per 100 person years). Independent predictors of syphilis acquisition based on a Cox proportional hazards model included age less than 20 years, lack of formal education, earlier calendar year of follow up, and recent HIV-1 infection. Based on a median follow up time of 11 months, the incidence of HIV-1 was 5.8 per 100 person years (95% CI 5.0 to 6.6 per 100 person years). Using a Cox proportional hazards model to adjust for known HIV risk factors, the adjusted hazard ratio of HIV-1 infection associated with incident syphilis was 4.44 (95% CI 2.96 to 6.65; p<0.001). CONCLUSIONS: A high incidence rate of syphilis was observed among STI clinic attendees. The elevated risk of HIV-1 infection that was observed among participants with incident syphilis supports the hypothesis that syphilis enhances the sexual transmission of HIV-1 and highlights the importance of early diagnosis and treatment of syphilis. JF - Sexually Transmitted Infections AU - Reynolds, S J AU - Risbud, A R AU - Shepherd, M E AU - Rompalo, A M AU - Ghate, M V AU - Godbole, S V AU - Joshi, S N AU - Divekar, A D AU - Gangakhedkar, R R AU - Bollinger, R C AU - Mehendale, S M AD - Johns Hopkins University, Baltimore, MD, USA. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. National AIDS Research Institute, Pune, India Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 121 EP - 126 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 82 IS - 2 SN - 1368-4973, 1368-4973 KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Risk assessment KW - Age KW - Ulcers KW - Risk factors KW - Human immunodeficiency virus 1 KW - Treponema pallidum KW - Microscopy KW - Infection KW - Syphilis KW - Disease transmission KW - Models KW - V 22005:AIDS: Epidemiological aspects KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19966738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=High+rates+of+syphilis+among+STI+patients+are+contributing+to+the+spread+of+HIV-1+in+India&rft.au=Reynolds%2C+S+J%3BRisbud%2C+A+R%3BShepherd%2C+M+E%3BRompalo%2C+A+M%3BGhate%2C+M+V%3BGodbole%2C+S+V%3BJoshi%2C+S+N%3BDivekar%2C+A+D%3BGangakhedkar%2C+R+R%3BBollinger%2C+R+C%3BMehendale%2C+S+M&rft.aulast=Reynolds&rft.aufirst=S&rft.date=2006-04-01&rft.volume=82&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; Ulcers; Risk factors; Microscopy; Infection; Syphilis; Models; Disease transmission; Treponema pallidum; Human immunodeficiency virus 1 ER - TY - JOUR T1 - National Prevalence and Exposure Risk for Cockroach Allergen in U.S. Households AN - 19961991; 6963711 AB - We characterized the prevalence of cockroach allergen exposure in a nationally representative sample of U.S. homes and assessed risk factors for elevated concentrations. We used data from the National Survey of Lead and Allergens in Housing, a population-based cross-sectional survey. Participants were residents of 831 U.S. homes in the survey. We analyzed allergen, questionnaire, and observational data of 831 U.S. homes. Cockroach allergen (Bla g 1) concentrations exceed 2.0 U/g, a level associated with allergic sensitization, in 11% of U.S. living room floors and 13% of kitchen floors. Concentrations exceed 8.0 U/g, a level associated with asthma morbidity, in 3% of living room floors and 10% of kitchen floors. Elevated concentrations were observed in high-rise apartments, urban settings, pre-1940 constructions, and households with incomes 8.0 U/g were greatest when roach problems were reported or observed and increased with the number of cockroaches observed and with indications of recent cockroach activity. Household cockroach allergen exposure is characterized in a nationally representative context. The allergen is prevalent in many settings, at levels that may contribute to allergic sensitization and asthma morbidity. Likelihood of exposure can be assessed by consideration of demographic and household determinants. JF - Environmental Health Perspectives AU - Cohn, R D AU - Arbes, SJ Jr AU - Jaramillo, R AU - Reid, L H AU - Zeldin, D C AD - National Institute of Environmental Health Sciences/National Institutes of Health, 111 Alexander Dr., Mail Drop D2-02, Research Triangle Park, NC 27709, USA, zeldin@niehs.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 522 EP - 526 VL - 114 IS - 4 SN - 0091-6765, 0091-6765 KW - American cockroaches KW - Entomology Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Data processing KW - Housing KW - Environmental health KW - Asthma KW - Respiratory diseases KW - Kitchens KW - Morbidity KW - Lead KW - Demography KW - USA KW - Blattidae KW - Allergens KW - Risk factors KW - Residential areas KW - Z 05300:General KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - X 24173:Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19961991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=National+Prevalence+and+Exposure+Risk+for+Cockroach+Allergen+in+U.S.+Households&rft.au=Cohn%2C+R+D%3BArbes%2C+SJ+Jr%3BJaramillo%2C+R%3BReid%2C+L+H%3BZeldin%2C+D+C&rft.aulast=Cohn&rft.aufirst=R&rft.date=2006-04-01&rft.volume=114&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8561 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Housing; Risk factors; Allergens; Asthma; Lead; Morbidity; Kitchens; Residential areas; Environmental health; Respiratory diseases; Blattidae; USA DO - http://dx.doi.org/10.1289/ehp.8561 ER - TY - JOUR T1 - Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation AN - 19960020; 6814586 AB - Despite recent emerging evidence suggesting that cancer stem cells subsist in a variety of tumors, it is not yet fully elucidated whether postnatal stem cells are directly involved in tumorigenesis. We used murine bone marrow-derived mesenchymal stem cells (BMMSCs) as a model to test a hypothesis that tumorigenesis may originate from spontaneous mutation of stem cells. In this study, we demonstrated that murine BMMSCs, after numerous passages, obtained unlimited population doublings and proceeded to a malignant transformation state, resulting in fibrosarcoma formation in vivo. Transformed BMMSCs colonized to multiple organs when delivered systemically through the tail vein. Fibrosarcoma cells formed by transformed BMMSCs contained cancer progenitors, which were capable of generating colony clusters in vitro and fibrosarcoma in vivo by the second administration. The mechanism by which BMMSCs transformed to malignant cells was associated with accumulated chromosomal abnormalities, gradual elevation in telomerase activity, and increased c-myc expression. Moreover, BMMSCs and their transformed counterpart, fibrosarcoma-forming cells, demonstrated different sensitivity to anti-cancer drugs. BMMSCs/fibrosarcoma transformation system may provide an ideal system to elucidate the mechanism of how stem cells become cancer cells and to screen anti-sarcoma drugs. JF - Stem Cells AU - Miura, Masako AU - Miura, Yasuo AU - Padilla-Nash, Hesed M AU - Molinolo, Alfredo A AU - Fu, Baojin AU - Patel, Vyomesh AU - Seo, Byoung-Moo AU - Sonoyama, Wataru AU - Zheng, Jenny J AU - Baker, Carl C AU - Chen, Wanjun AU - Ried, Thomas AU - Shi, Songtao AD - Dental Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1095 EP - 1103 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Transformation KW - Fibrosarcoma KW - Telomerase KW - Tails KW - Tumorigenesis KW - Animal models KW - Bone marrow KW - Cancer KW - Colonies KW - Stem cells KW - Veins KW - Genomic instability KW - Mesenchyme KW - Mutation KW - c-Myc protein KW - G 07470:Cytogenetics & general KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Accumulated+Chromosomal+Instability+in+Murine+Bone+Marrow+Mesenchymal+Stem+Cells+Leads+to+Malignant+Transformation&rft.au=Miura%2C+Masako%3BMiura%2C+Yasuo%3BPadilla-Nash%2C+Hesed+M%3BMolinolo%2C+Alfredo+A%3BFu%2C+Baojin%3BPatel%2C+Vyomesh%3BSeo%2C+Byoung-Moo%3BSonoyama%2C+Wataru%3BZheng%2C+Jenny+J%3BBaker%2C+Carl+C%3BChen%2C+Wanjun%3BRied%2C+Thomas%3BShi%2C+Songtao&rft.aulast=Miura&rft.aufirst=Masako&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Fibrosarcoma; Tails; Telomerase; Tumorigenesis; Bone marrow; Animal models; Cancer; Stem cells; Colonies; Genomic instability; Veins; Mesenchyme; Mutation; c-Myc protein ER - TY - JOUR T1 - Enhanced transduction of mouse salivary glands with AAV5-based vectors AN - 19853814; 6782987 AB - We previously demonstrated that recombinant adeno-asso-ciated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells in vitro and in vivo. However, it is not known how other rAAV serotypes perform when infused into salivary glands. The capsids of serotypes 4 and 5 are distinct from rAAV2 and from each other, suggesting that they may direct binding and entry into different cell types. In the present study, we investigated the tropisms, transduction efficiencies, and antibody response to AAV vectors based on AAV serotypes 2, 4, and 5. Administration of rAAV2 beta -galactosidase ( beta gal), rAAV4 beta gal, or rAAV5 beta gal to murine submandibular salivary glands by retrograde ductal instillation resulted in efficient transduction of salivary epithelial cells, with AAV4 and AAV5 producing 2.3 and 7.3 times more beta gal activity compared with AAV2. improved transduction with AAV5 was confirmed by QPCR of DNA extracted from glands and immunohisto-chemical staining for transgene expression. Like AAV2, AAV5 primarily transduced striated and intercalated ductal cells. AAV4 transduction was evident in striated, intercalated, and excretory ductal cells, as well as in convoluted granular tubules. In keeping with the encapsulated nature of the salivary gland, the majority of persistent viral genomes were found in the gland and not in other tissues. Neutralizing antibodies (NABs) found in the serum of virus-infused animals were serotype specific and there was no cross-reactivity between serotypes. No NABs were detected in saliva but sialic acid conjugates present in saliva could neutralize AAV4 at low dilutions. Together our data suggest that because of differences in receptor binding and transduction pathways, other serotypes may have improved utility as gene transfer vectors in the salivary gland and these differences could be exploited in gene therapy applications. JF - Gene Therapy AU - Katano, H AU - Kok, M R AU - Cotrim, A P AU - Yamano, S AU - Schmidt, M AU - Afione, S AU - Baum, B J AU - Chiorini, JA AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, US Department of Health and Human Services, NIH 10/1N113, 10 Center Dr, MSC1190, Bethesda, MD 20892, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 594 EP - 601 VL - 13 IS - 7 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Capsids KW - Genomes KW - Epithelial cells KW - Data processing KW - Cross-reactivity KW - Serotypes KW - Gene therapy KW - Tropism KW - Antibody response KW - Salivary gland KW - Adeno-associated virus KW - Expression vectors KW - DNA KW - Saliva KW - Sialic acids KW - Tubules KW - W3 33181:Gene therapy vectors KW - V 22410:Animal Diseases KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19853814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Enhanced+transduction+of+mouse+salivary+glands+with+AAV5-based+vectors&rft.au=Katano%2C+H%3BKok%2C+M+R%3BCotrim%2C+A+P%3BYamano%2C+S%3BSchmidt%2C+M%3BAfione%2C+S%3BBaum%2C+B+J%3BChiorini%2C+JA&rft.aulast=Katano&rft.aufirst=H&rft.date=2006-04-01&rft.volume=13&rft.issue=7&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fsj.gt.3302691 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Capsids; Epithelial cells; Serotypes; Cross-reactivity; Data processing; Gene therapy; Tropism; Antibody response; Salivary gland; Expression vectors; DNA; Saliva; Sialic acids; Tubules; Adeno-associated virus DO - http://dx.doi.org/10.1038/sj.gt.3302691 ER - TY - JOUR T1 - Evaluation of Prime/Boost Regimens Using Recombinant Poxvirus/Tyrosinase Vaccines for the Treatment of Patients with Metastatic Melanoma AN - 19844633; 6814719 AB - PURPOSE: Two clinical trials were conducted to evaluate the clinical efficacy and immunologic impact of vaccination against the tyrosinase protein plus systemic interleukin 2 (IL-2) administration in patients with advanced metastatic melanoma. Experimental Design: Full-length tyrosinase was employed as an immunogen to induce diverse immunologic responses against a commonly expressed melanoma antigen. Heterologous prime/boost vaccination with recombinant vaccinia and fowlpox vectors encoding tyrosinase was first explored in a randomized three-arm phase II trial, in which vaccines were administered alone or concurrently with low-dose or high-dose IL-2. In a subsequent single cohort phase II trial, all patients received the same vaccines and high-dose IL-2 sequentially rather than concurrently. RESULTS: Among a total of 64 patients treated on these trials, 8 objective partial responses (12.5%) were observed, all in patients receiving high-dose IL-2. Additional patients showed evidence of lesional regression (mixed tumor response) or overall regression that did not achieve partial response status (minor response). In vitro evidence of enhanced immunity against tyrosinase following protocol treatments was documented in 3 of 49 (6%) patients tested serologically, 3 of 23 (13%) patients tested for T-cell recognition of individual tyrosinase peptides, and 4 of 16 (25%) patients tested for T-cell recognition of full-length tyrosinase protein with real-time reverse transcription-PCR techniques. CONCLUSIONS: Whereas prime/boost immunization with recombinant vaccinia and fowlpox viruses enhanced antityrosinase immunity in some patients with metastatic melanoma, it was ineffective alone in mediating clinical benefit, and in combination with IL-2 did not mediate clinical benefit significantly different from that expected from treatment with IL-2 alone. JF - Clinical Cancer Research AU - Lindsey, Kimberly R AU - Gritz, Linda AU - Sherry, Richard AU - Abati, Andrea AU - Fetsch, Patricia A AU - Goldfeder, Lisa C AU - Gonzales, Monica I AU - Zinnack, Kimberly A AU - Rogers-Freezer, Linda AU - Haworth, Leah AU - Mavroukakis, Sharon A AU - White, Donald E AU - Steinberg, Seth M AU - Restifo, Nicholas P AU - Panicali, Dennis L AU - Rosenberg, Steven A AU - Topalian, Suzanne L AD - Surgery Branch, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2526 EP - 2537 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 8 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Fowlpox KW - Interleukin 2 KW - Vaccinia KW - tyrosinase KW - Tumors KW - Immunity KW - Clinical trials KW - Monophenol monooxygenase KW - Melanoma KW - Metastases KW - Poxvirus KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Vaccines KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Evaluation+of+Prime%2FBoost+Regimens+Using+Recombinant+Poxvirus%2FTyrosinase+Vaccines+for+the+Treatment+of+Patients+with+Metastatic+Melanoma&rft.au=Lindsey%2C+Kimberly+R%3BGritz%2C+Linda%3BSherry%2C+Richard%3BAbati%2C+Andrea%3BFetsch%2C+Patricia+A%3BGoldfeder%2C+Lisa+C%3BGonzales%2C+Monica+I%3BZinnack%2C+Kimberly+A%3BRogers-Freezer%2C+Linda%3BHaworth%2C+Leah%3BMavroukakis%2C+Sharon+A%3BWhite%2C+Donald+E%3BSteinberg%2C+Seth+M%3BRestifo%2C+Nicholas+P%3BPanicali%2C+Dennis+L%3BRosenberg%2C+Steven+A%3BTopalian%2C+Suzanne+L&rft.aulast=Lindsey&rft.aufirst=Kimberly&rft.date=2006-04-01&rft.volume=12&rft.issue=8&rft.spage=2526&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 2; Fowlpox; Vaccinia; tyrosinase; Immunity; Tumors; Clinical trials; Monophenol monooxygenase; Melanoma; Metastases; Antigen (tumor-associated); Lymphocytes T; Vaccines; Poxvirus ER - TY - JOUR T1 - Multidimensional Volumetric Imaging of Pulmonary Infiltrates for Measuring Therapeutic Response to Antifungal Therapy in Experimental Invasive Pulmonary Aspergillosis AN - 19837922; 6750091 AB - Pulmonary infiltrates in neutropenic hosts with invasive pulmonary aspergillosis are caused by vascular invasion, hemorrhagic infarction, and tissue necrosis. Monitoring the dynamics of pulmonary infiltrates of invasive aspergillosis is an important tool for assessing response to antifungal therapy. We, therefore, introduced a multidimensional volumetric imaging (MDVI) method for analysis of the response of the volume of pulmonary infiltrates over time to antifungal therapy in experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. We developed a semiautomatic method to measure the volume of lung lesions, which was implemented as an extension of the MEDx visualization and analysis software using ultrafast computerized tomography (UFCT). Volumetric infiltrate measures were compared with UFCT reading, histopathological resolution of lesions, microbiological clearance of Aspergillus fumigatus, and galactomannan index (GMI). We also studied the MDVI method for consistency and reproducibility in comparison to UFCT. Treatment groups consisted of deoxycholate amphotericin B (DAMB) at 0.5 or 1 mg/kg of body weight/day and untreated controls (UC). Therapeutic monitoring of pulmonary infiltrates using MDVI demonstrated a significant decrease in the infiltrate volume in DAMB-treated rabbits in comparison to UC (P less than or equal to 0.001). Volumetric data by MDVI correlated with conventional CT pulmonary scores (r = 0.83, P less than or equal to 0.001). These results correlated with validated biological endpoints: pulmonary infarct scores (r = 0.85, P less than or equal to 0.001), lung weights (r = 0.76, P less than or equal to 0.01), residual fungal burden (r = 0.65, P less than or equal to 0.05), and GMI (r = 0.78, P less than or equal to 0.01). MDVI correlated with key biological markers, improved the objectivity of radiological assessment of therapeutic response to antifungal therapy, and warrants evaluation for monitoring therapeutic response in immunocompromised patients with invasive aspergillosis. JF - Antimicrobial Agents & Chemotherapy AU - Petraitis, Vidmantas AU - Petraitiene, Ruta AU - Solomon, Jeffrey AU - Kelaher, Amy M AU - Murray, Heidi A AU - Mya-San, Christine AU - Bhandary, Avi K AU - Sein, Tin AU - Avila, Nilo A AU - Basevicius, Algidas AU - Bacher, John AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. SAIC-Frederick, Inc., Frederick, Maryland. Medical Numerics, Inc., Sterling, Virginia. Department of Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland. Departments of Radiology, Kaunas University of Medicine, Kaunus, Lithuania. Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1510 EP - 1517 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Data processing KW - Aspergillosis KW - Hemorrhage KW - biomarkers KW - Antimicrobial agents KW - Computer programs KW - Neutropenia KW - Necrosis KW - software KW - Body weight KW - Lung KW - Aspergillus fumigatus KW - Immunocompromised hosts KW - Computed tomography KW - Language KW - Infarction KW - Vascular system KW - A 01340:Antibiotics & Antimicrobials KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19837922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Multidimensional+Volumetric+Imaging+of+Pulmonary+Infiltrates+for+Measuring+Therapeutic+Response+to+Antifungal+Therapy+in+Experimental+Invasive+Pulmonary+Aspergillosis&rft.au=Petraitis%2C+Vidmantas%3BPetraitiene%2C+Ruta%3BSolomon%2C+Jeffrey%3BKelaher%2C+Amy+M%3BMurray%2C+Heidi+A%3BMya-San%2C+Christine%3BBhandary%2C+Avi+K%3BSein%2C+Tin%3BAvila%2C+Nilo+A%3BBasevicius%2C+Algidas%3BBacher%2C+John%3BWalsh%2C+Thomas+J&rft.aulast=Petraitis&rft.aufirst=Vidmantas&rft.date=2006-04-01&rft.volume=50&rft.issue=4&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Data processing; Aspergillosis; Hemorrhage; biomarkers; Antimicrobial agents; Neutropenia; Computer programs; software; Necrosis; Body weight; Lung; Immunocompromised hosts; Computed tomography; Language; Infarction; Vascular system; Aspergillus fumigatus ER - TY - JOUR T1 - Down-regulation of CXCL5 Inhibits Squamous Carcinogenesis AN - 19823910; 6810055 AB - We report a novel role for the CXC-chemokine, CXCL5, in the proliferation and invasion of head and neck squamous cell carcinoma (HNSCC). Previously, we reported transcriptional up-regulation of CXCL5 in metastatic cells. In this study, we provide biological validation of these findings and show that CXCL5 is intimately involved in tumor cell proliferation, migration, and invasion. Cells derived from a lymph node metastasis, but not from a synchronous primary tumor, secreted CXCL5 as judged by Western blotting of conditioned media. We used RNA interference to generate cell lines (shL5) in which CXCL5 expression was greatly reduced, and tested whether this modulated the cell phenotype. shL5 cells showed decreased proliferation compared with cells harboring nontargeting control sequences. In addition, we found that the ability of shL5 cells to migrate and invade in vitro through a basement membrane substitute was greatly impaired compared with control cells. Finally, whereas control cells were highly tumorigenic in nude mice, the tumorigenic potential in vivo of shL5 cells was found to be ablated. Taken together, these data suggest that CXCL5 production contributes to both enhanced proliferation and invasion of squamous cell carcinomas and that targeting of chemokine pathways may represent a potential therapeutic modality for these lesions. (Cancer Res 2006; 66(8):4279-84) JF - Cancer Research AU - Miyazaki, Hiroshi AU - Patel, Vyomesh AU - Wang, Huixin AU - Edmunds, Ryan K AU - Gutkind, JSilvio AU - Yeudall, WAndrew AD - Philips Institute, Department of Biochemistry, and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia and Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4279 EP - 4284 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 8 SN - 0008-5472, 0008-5472 KW - CXCL5 protein KW - Toxicology Abstracts; Immunology Abstracts KW - Western blotting KW - Chemokines KW - Data processing KW - Transcription KW - squamous cell carcinoma KW - Tumors KW - Tumor cells KW - Lymph nodes KW - Metastases KW - Basement membranes KW - Carcinogenesis KW - RNA-mediated interference KW - Head and neck cancer KW - Cell migration KW - Cell proliferation KW - F 06152:Tumor Immunology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19823910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Down-regulation+of+CXCL5+Inhibits+Squamous+Carcinogenesis&rft.au=Miyazaki%2C+Hiroshi%3BPatel%2C+Vyomesh%3BWang%2C+Huixin%3BEdmunds%2C+Ryan+K%3BGutkind%2C+JSilvio%3BYeudall%2C+WAndrew&rft.aulast=Miyazaki&rft.aufirst=Hiroshi&rft.date=2006-04-01&rft.volume=66&rft.issue=8&rft.spage=4279&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Western blotting; Chemokines; Data processing; Transcription; squamous cell carcinoma; Tumors; Tumor cells; Lymph nodes; Metastases; Basement membranes; Carcinogenesis; Head and neck cancer; RNA-mediated interference; Cell migration; Cell proliferation ER - TY - JOUR T1 - Effect of Serotype 5 Adenoviral and Serotype 2 Adeno-Associated Viral Vector-Mediated Gene Transfer to Salivary Glands on the Composition of Saliva AN - 19773776; 6819734 AB - Key to the development of a useful clinical therapy is the minimization of side effects. Routine safety testing, however, does not provide information about the physiological status of many potentially useful gene transfer target sites. In this study, we evaluated the longitudinal effects of intrasalivary duct delivery of recombinant serotype 5 adenoviral (rAd5; 10 super(9)-10 super(10) particles/gland in rats) and recombinant serotype 2 adeno-asso-ciated viral (rAAV2; 10 super(8)-10 super(9) particles/gland in mice) vectors on salivary composition. Both vectors led to modest, transient alterations in several salivary components that thereafter returned to normal. The changes suggested two initial specific consequences of rAd5 and rAAV2 vector administration: (1) a modest breach of the mucosal barrier in the targeted glands, indicated by elevations in salivary albumin, total protein, and Na super(+) levels, and (2) an innate host response, indicated by transient elevations in either salivary lactoferrin and IgA levels (rAd5) or mucin (rAAV2). These studies are consistent with the notion that administration of modest doses of rAd5 and rAAV2 vectors to salivary glands for a therapeutic purpose can be accomplished without severe or permanent injury to the target tissue, or compromise to its essential exocrine physiological function. JF - Human Gene Therapy AU - Wang, J AU - Voutetakis, A AU - Mineshiba, F AU - Illei, G G AU - Dang, H AU - Yeh, C-K AU - Baum, B J AD - GTTB, NIDCR, NIH, Building 10, Room 1N113, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 455 EP - 463 VL - 17 IS - 4 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Serotypes KW - Gene therapy KW - Injuries KW - Mucosa KW - Adenovirus KW - Therapeutic applications KW - Vectors KW - Salivary gland KW - Expression vectors KW - Immunoglobulin A KW - lactoferrin KW - Albumin KW - mucin KW - Saliva KW - Side effects KW - W3 33181:Gene therapy vectors KW - V 22410:Animal Diseases KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Effect+of+Serotype+5+Adenoviral+and+Serotype+2+Adeno-Associated+Viral+Vector-Mediated+Gene+Transfer+to+Salivary+Glands+on+the+Composition+of+Saliva&rft.au=Wang%2C+J%3BVoutetakis%2C+A%3BMineshiba%2C+F%3BIllei%2C+G+G%3BDang%2C+H%3BYeh%2C+C-K%3BBaum%2C+B+J&rft.aulast=Wang&rft.aufirst=J&rft.date=2006-04-01&rft.volume=17&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serotypes; Injuries; Gene therapy; Mucosa; Vectors; Therapeutic applications; Salivary gland; Expression vectors; Immunoglobulin A; Albumin; lactoferrin; mucin; Saliva; Side effects; Adenovirus ER - TY - JOUR T1 - Characterization of a Soluble Ligand Binding Domain of the NMDA Receptor Regulatory Subunit NR3A AN - 19770089; 6813187 AB - NR3A is expressed widely in the developing CNS of mammals. Coassembly of NR3A with NR1 and NR2 modifies NMDA receptor-mediated responses, reducing calcium permeability and single-channel conductance. The ligand binding properties of NR3A are unknown but shape the role NR3A plays when incorporated into NMDA receptors. Here, a soluble NR3A ligand binding domain (NR3A S1S2) was constructed based on amino acid sequence alignments with other glutamate receptor ion channels and is expressed in Escherichia coli. After purification by affinity, gel filtration, and ion exchange chromatography, NR3A S1S2 behaves as a monomer even at a concentration of 20 mg/ml, as determined by size-exclusion chromatography and dynamic light scattering. NR3A S1S2 has very high affinity for glycine with an apparent dissociation constant (K sub(d)) of 40 nM, 650-fold less than the K sub(d) for NR1. Glutamate, which binds to NR2 subunits, also binds to NR3A, but with very low affinity (K sub(d) = 9.6 mM); in contrast, binding of glutamate to NR1 was not detectable even at a 300 mM concentration. The antagonist binding profiles of NR3A and NR1 also show striking differences. 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX), and its analog CGP78608, bind to NR3A S1S2 with low micromolar affinity, whereas for NR1, the affinity of CGP78608 increases 1000-fold compared with CNQX. Other high-affinity NR1 antagonists also show very weak binding to NR3A. Proteolysis protection experiments reveal that CNQX and CGP78608 bind to and stabilize domain 1 of NR3A S1S2 but increase proteolysis of domain 2, indicating that they produce conformational changes distinct from those induced by glycine and D-serine. JF - Journal of Neuroscience AU - Yao, Yongneng AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4559 EP - 4566 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 17 SN - 0270-6474, 0270-6474 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Proteolysis KW - Central nervous system KW - N-Methyl-D-aspartic acid receptors KW - Receptor mechanisms KW - Glycine KW - Chromatography KW - Conductance KW - Light scattering KW - Glutamic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Calcium permeability KW - Monomers KW - Filtration KW - D-Serine KW - Nervous system KW - Regulatory subunits KW - Ion channels KW - Escherichia coli KW - Purification KW - Ion exchange KW - Amino acid sequence KW - N3 11071:Membranes, receptors, and channels KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Characterization+of+a+Soluble+Ligand+Binding+Domain+of+the+NMDA+Receptor+Regulatory+Subunit+NR3A&rft.au=Yao%2C+Yongneng%3BMayer%2C+Mark+L&rft.aulast=Yao&rft.aufirst=Yongneng&rft.date=2006-04-01&rft.volume=26&rft.issue=17&rft.spage=4559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Central nervous system; N-Methyl-D-aspartic acid receptors; Receptor mechanisms; Conductance; Chromatography; Glycine; Light scattering; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Calcium permeability; Monomers; Nervous system; D-Serine; Filtration; Regulatory subunits; Ion channels; Purification; Ion exchange; Amino acid sequence; Escherichia coli ER - TY - JOUR T1 - Defining a Developmental Path to Neural Fate by Global Expression Profiling of Mouse Embryonic Stem Cells and Adult Neural Stem/Progenitor Cells AN - 19769819; 6814603 AB - To understand global features of gene expression changes during in vitro neural differentiation, we carried out the microarray analysis of embryonic stem cells (ESCs), embryonal carcinoma cells, and adult neural stem/progenitor (NS) cells. Expression profiling of ESCs during differentiation in monolayer culture revealed three distinct phases: undifferentiated ESCs, primitive ectoderm-like cells, and neural progenitor cells. Principal component (PC) analysis revealed that these cells were aligned on PC1 over the course of 6 days. This PC1 represents approximately 4,000 genes, the expression of which increased with neural commitment/differentiation. Furthermore, NS cells derived from adult brain and their differentiated cells were positioned along this PC axis further away from undifferentiated ESCs than embryonic stem-derived neural progenitors. We suggest that this PC1 defines a path to neural fate, providing a scale for the degree of commitment/differentiation. JF - Stem Cells AU - Aiba, Kazuhiro AU - Sharov, Alexei A AU - Carter, Mark G AU - Foroni, Chiara AU - Vescovi, Angelo L AU - Ko, Minoru SH AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Institute for Stem Cell Research, Ospedale San Raffaele, Milan, Italy Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 889 EP - 895 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 4 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Gene expression KW - Differentiation KW - Stem cells KW - Embryo cells KW - Brain KW - Embryos KW - Cell culture KW - Neural stem cells KW - N3 11003:Developmental neuroscience KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19769819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Defining+a+Developmental+Path+to+Neural+Fate+by+Global+Expression+Profiling+of+Mouse+Embryonic+Stem+Cells+and+Adult+Neural+Stem%2FProgenitor+Cells&rft.au=Aiba%2C+Kazuhiro%3BSharov%2C+Alexei+A%3BCarter%2C+Mark+G%3BForoni%2C+Chiara%3BVescovi%2C+Angelo+L%3BKo%2C+Minoru+SH&rft.aulast=Aiba&rft.aufirst=Kazuhiro&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Differentiation; Stem cells; Embryo cells; Brain; Cell culture; Embryos; Neural stem cells ER - TY - JOUR T1 - Modulating RssB activity: IraP, a novel regulator of sigma super(S) stability in Escherichia coli AN - 19768048; 6751997 AB - The sigma super(S) subunit of Escherichia coli RNA polymerase regulates the expression of stationary phase and stress response genes. sigma super(S) is highly unstable in exponentially growing cells, whereas its stability increases dramatically upon starvation or under certain stress conditions. The degradation of sigma super(S) is controlled by the phosphorylatable adaptor protein RssB and the ClpXP protease. RssB specifically directs sigma super(S) to ClpXP. An unanswered question is how RssB-mediated degradation of sigma super(S) is blocked by conditions such as glucose or phosphate starvation. We report here the identification and characterization of a new regulator of sigma super(S) stability, IraP (inhibitor of RssB activity during phosphate starvation), that stabilizes sigma super(S) both in vivo and in vitro. Deletion of iraP interferes with sigma super(S) stabilization during phosphate starvation, but not during carbon starvation, and has a partial effect in stationary phase and nitrogen starvation. IraP interferes with RssB-dependent degradation of sigma super(S) through a direct protein-protein interaction with RssB. A point mutant of IraP was isolated and found to be defective both for inhibition of sigma super(S) degradation and interaction with RssB. Our results reveal a novel mechanism of regulation of sigma super(S) stability through the regulation of RssB activity and identify IraP as a member of a new class of regulators, the anti-adaptor proteins. JF - Genes & Development AU - Bougdour, Alexandre AU - Wickner, Sue AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 884 EP - 897 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 20 IS - 7 SN - 0890-9369, 0890-9369 KW - ClpXP protease KW - IraP protein KW - RssB protein KW - sigma S factor KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Starvation KW - Glucose KW - Stress KW - stationary phase KW - DNA-directed RNA polymerase KW - adaptor proteins KW - Gene deletion KW - Carbon KW - Phosphate KW - Escherichia coli KW - Protein turnover KW - Proteinase KW - Environmental stress KW - Protein interaction KW - Nitrogen KW - J 02410:Animal Diseases KW - G 07320:Bacterial genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19768048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Modulating+RssB+activity%3A+IraP%2C+a+novel+regulator+of+sigma+super%28S%29+stability+in+Escherichia+coli&rft.au=Bougdour%2C+Alexandre%3BWickner%2C+Sue%3BGottesman%2C+Susan&rft.aulast=Bougdour&rft.aufirst=Alexandre&rft.date=2006-04-01&rft.volume=20&rft.issue=7&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Starvation; Glucose; Stress; stationary phase; Gene deletion; adaptor proteins; DNA-directed RNA polymerase; Carbon; Phosphate; Protein turnover; Environmental stress; Proteinase; Protein interaction; Nitrogen; Escherichia coli ER - TY - JOUR T1 - Multi-slice Computed Tomography Appearance of Abscess of Cavum Septum Pellucidum: A Case Report and Review of the Literature AN - 19615125; 7331515 AB - Abscesses involving the cavum septum pellucidum are rare and, owing to their location, detection may be difficult with routine conventional computed tomography (CT). Only a few isolated cases have been reported and mostly in children. We report a case of abscess involving the cavum septum pellucidum in an adult and its appearance on multi-slice spiral CT. JF - Acta Radiologica AU - Vasudev, M K AU - Chavan, R G AU - Nagarajan, K AU - Shukla, D AU - Devi, B I AD - Departments of Neuroimaging and Interventional Radiology and Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 301 EP - 302 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 47 IS - 3 SN - 0284-1851, 0284-1851 KW - Biotechnology and Bioengineering Abstracts KW - Abscess KW - cavum septum pellucidum KW - multi-slice CT KW - surgery KW - Case reports KW - Computed tomography KW - Septum KW - Abscesses KW - Children KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19615125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Radiologica&rft.atitle=Multi-slice+Computed+Tomography+Appearance+of+Abscess+of+Cavum+Septum+Pellucidum%3A+A+Case+Report+and+Review+of+the+Literature&rft.au=Vasudev%2C+M+K%3BChavan%2C+R+G%3BNagarajan%2C+K%3BShukla%2C+D%3BDevi%2C+B+I&rft.aulast=Vasudev&rft.aufirst=M&rft.date=2006-04-01&rft.volume=47&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Acta+Radiologica&rft.issn=02841851&rft_id=info:doi/10.1080%2F02841850500492449 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Case reports; Computed tomography; Septum; Children; Abscesses DO - http://dx.doi.org/10.1080/02841850500492449 ER - TY - JOUR T1 - Imaging specific cell-surface proteolytic activity in single living cells AN - 19442399; 6866122 AB - We describe a simple, sensitive and noninvasive assay that uses nontoxic, reengineered anthrax toxin-beta-lactamase fusion proteins with altered protease cleavage specificity to visualize specific cell-surface proteolytic activity in single living cells. The assay could be used to specifically image endogenous cell-surface furin, urokinase plasminogen activator and metalloprotease activity. We have adapted the assay for fluorescence microscopy, flow cytometry and fluorescent plate reader formats, and it is amenable for automation and high-throughput analysis. JF - Nature Methods AU - Hobson, John P AU - Liu, Shihui AU - Roenoe, Birgitte AU - Leppla, Stephen H AU - Bugge, Thomas H AD - Proteases and Tissue Remodeling Unit, National Institute of Dental and Craniofacial Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland 20892, USA., leppla@nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 259 EP - 261 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 4 SN - 1548-7091, 1548-7091 KW - Biotechnology and Bioengineering Abstracts KW - Metalloproteinase KW - Flow cytometry KW - Proteolysis KW - Fluorescence KW - Automation KW - Anthrax KW - Fusion protein KW - u-Plasminogen activator KW - imaging KW - plasminogen KW - furin KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=Imaging+specific+cell-surface+proteolytic+activity+in+single+living+cells&rft.au=Hobson%2C+John+P%3BLiu%2C+Shihui%3BRoenoe%2C+Birgitte%3BLeppla%2C+Stephen+H%3BBugge%2C+Thomas+H&rft.aulast=Hobson&rft.aufirst=John&rft.date=2006-04-01&rft.volume=3&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth862 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Proteolysis; u-Plasminogen activator; imaging; furin; Flow cytometry; Metalloproteinase; Fusion protein; Fluorescence; plasminogen; Anthrax; Automation DO - http://dx.doi.org/10.1038/nmeth862 ER - TY - JOUR T1 - An Efficient Method for the Derivation of Mouse Embryonic Stem Cells AN - 19441470; 6814598 AB - Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers; however, the process of ESC derivation is often very inefficient and requires high specialization, training, and expertise. To circumvent these limitations, we aimed to develop a simple and efficient protocol based on the use of commercially available products. Here, we present an optimized protocol that we successfully applied to derive ESCs from several knockout mouse strains (Wnt-1, Wnt-5a, Lrp6, and parkin) with 50%-75% efficiency. The methodology is based on the use of mouse embryonic fibroblast feeders, knockout serum replacement (SR), and minimal handling of the blastocyst. In this protocol, all centrifugation steps (as well as the use of trypsin inhibitor) were avoided and replaced by an ESC medium containing fetal calf serum (FCS) after the trypsinizations. We define the potential advantages and disadvantages of using SR and FCS in individual steps of the protocol. We also characterize the ESCs for the expression of ESC markers by immunohistochemistry, Western blot, and a stem cell focused microarray. In summary, we provide a simplified and improved protocol to derive mESCs that can be useful for laboratories aiming to isolate transgenic mESCs for the first time. JF - Stem Cells AU - Bryja, Vitezlav AU - Bonilla, Sonia AU - Cajanek, Lukas AU - Parish, Clare L AU - Schwartz, Catherine M AU - Luo, Yongquan AU - Rao, Mahendra S AU - Arenas, Ernest AD - Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 844 EP - 849 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Western blotting KW - parkin protein KW - Trypsin KW - Fetal calf serum KW - Specialization KW - Fibroblasts KW - Centrifugation KW - blastocysts KW - Stem cells KW - Embryo cells KW - Embryos KW - Immunohistochemistry KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19441470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=An+Efficient+Method+for+the+Derivation+of+Mouse+Embryonic+Stem+Cells&rft.au=Bryja%2C+Vitezlav%3BBonilla%2C+Sonia%3BCajanek%2C+Lukas%3BParish%2C+Clare+L%3BSchwartz%2C+Catherine+M%3BLuo%2C+Yongquan%3BRao%2C+Mahendra+S%3BArenas%2C+Ernest&rft.aulast=Bryja&rft.aufirst=Vitezlav&rft.date=2006-04-01&rft.volume=24&rft.issue=4&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stem cells; Embryo cells; Fibroblasts; parkin protein; Embryos; Trypsin; blastocysts; Immunohistochemistry; Western blotting; Specialization; Centrifugation; Fetal calf serum ER - TY - JOUR T1 - A Prospective Study of Night Shift Work, Sleep Duration, and Risk of Parkinson's Disease AN - 19440152; 6743209 AB - The authors prospectively investigated whether working rotating night shifts was associated with the risk of Parkinson's disease among 84,794 female nurses who reported years of night shift work in 1988 (the US Nurses' Health Study). After 975,912 person-years of follow-up (1988-2000), 181 incident Parkinson's disease cases were documented. Compared with nurses who never worked rotating night shifts, those with 15 years or more of night shift work had a 50% lower risk of Parkinson's disease after adjustment for age and smoking (95% confidence interval: 0.26, 0.97; p sub(trend) = 0.01). Sleep duration was positively associated with Parkinson's disease risk: The relative risk was 1.84 (95% confidence interval: 0.99, 3.42) when comparing nurses who reported 9 or more hours of sleep per day with those who slept 6 hours or less (p sub(trend) = 0.005). These data suggest that working night shifts may be protective against Parkinson's disease or that low tolerance for night shift work is an early marker of Parkinson's disease. Conversely, habitual longer sleep duration may be an earlier marker of Parkinson's disease. Because of the novelty and the exploratory nature of these findings, confirmation is needed. JF - American Journal of Epidemiology AU - Chen, Honglei AU - Schernhammer, Eva AU - Schwarzschild, Michael A AU - Ascherio, Alberto AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 726 EP - 730 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 163 IS - 8 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Smoking KW - shift work KW - Epidemiology KW - Parkinson's disease KW - nursing KW - working conditions KW - Medical personnel KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=A+Prospective+Study+of+Night+Shift+Work%2C+Sleep+Duration%2C+and+Risk+of+Parkinson%27s+Disease&rft.au=Chen%2C+Honglei%3BSchernhammer%2C+Eva%3BSchwarzschild%2C+Michael+A%3BAscherio%2C+Alberto&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2006-04-01&rft.volume=163&rft.issue=8&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoking; shift work; Epidemiology; Parkinson's disease; nursing; Medical personnel; working conditions; Occupational health ER - TY - JOUR T1 - Delivery of Liposomal Doxorubicin (Doxil) in a Breast Cancer Tumor Model: Investigation of Potential Enhancement by Pulsed-High Intensity Focused Ultrasound AN - 19438930; 6759080 AB - Rationale and Objectives To investigate the potential of using pulsed high-intensity focused ultrasound (HIFU) exposures to enhance the delivery, and hence therapeutic effect of liposomal doxorubicin (Doxil) in a murine breast cancer tumor model. Materials and Methods Tumors were grown in the bilateral flanks of mice using a mammary adenocarcinoma cell line. Experiments consisted of exposing one of two tumors to pulsed-HIFU, followed by tail vein injections of Doxil. Tumor growth rates were monitored, and assays carried out for doxorubicin concentration in these tumors as well as in a second (squamous cell carcinoma) tumor model and in muscle. Laser scanning confocal microscopy was used with fluorescent probes to observe both the uptake of polystyrene nanoparticles and dilation of exposed blood vessels. Additional experiments involving histologic analysis and real-time temperature measurements were performed to determine the safety of the exposures. Results Pulsed-HIFU exposures were shown to be safe, producing no apparent deleterious effects in the tumors. The exposures, however, were not found to enhance the delivery of Doxil, and consequently did not allow for lower doses for obtaining tumor regression. Imaging with a fluorescent dextran showed blood vessels to be dilated as a result of the exposures. Experiments with polystyrene nanoparticles of similar size to the liposomes showed a greater abundance to be present in the treated tumors. Conclusion Although past studies have shown the advantages of pulsed-HIFU exposures for enhancing delivery, this was not observed with the liposomes, apparently because of their inherent ability to preferentially accumulate into tumors on their own. Potential mechanisms for enhanced uptake of non-liposomal nanoparticles are discussed. JF - Academic Radiology AU - Frenkel, V AU - Etherington, A AU - Greene, M AU - Quijano, J AU - Xie, J AU - Hunter, F AU - Dromi, S AU - Li, KCP AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Building 10, Room 1N306a, 10 Center Drive, Bethesda, MD 20892, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 469 EP - 479 VL - 13 IS - 4 SN - 1076-6332, 1076-6332 KW - Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Temperature effects KW - Dextran KW - Tails KW - Abundance KW - Muscles KW - Animal models KW - Cell culture KW - squamous cell carcinoma KW - Tumors KW - imaging KW - Liposomes KW - Doxorubicin KW - Tumor cell lines KW - Veins KW - Blood vessels KW - Confocal microscopy KW - polystyrene KW - Fluorescent indicators KW - Breast cancer KW - Adenocarcinoma KW - Ultrasound KW - nanoparticles KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+Radiology&rft.atitle=Delivery+of+Liposomal+Doxorubicin+%28Doxil%29+in+a+Breast+Cancer+Tumor+Model%3A+Investigation+of+Potential+Enhancement+by+Pulsed-High+Intensity+Focused+Ultrasound&rft.au=Frenkel%2C+V%3BEtherington%2C+A%3BGreene%2C+M%3BQuijano%2C+J%3BXie%2C+J%3BHunter%2C+F%3BDromi%2C+S%3BLi%2C+KCP&rft.aulast=Frenkel&rft.aufirst=V&rft.date=2006-04-01&rft.volume=13&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Academic+Radiology&rft.issn=10766332&rft_id=info:doi/10.1016%2Fj.acra.2005.08.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; nanoparticles; Doxorubicin; Animal models; Blood vessels; Liposomes; Breast cancer; Ultrasound; polystyrene; Dextran; squamous cell carcinoma; Veins; Confocal microscopy; Temperature effects; Tumor cell lines; Growth rate; Cell culture; imaging; Tails; Adenocarcinoma; Abundance; Fluorescent indicators; Muscles DO - http://dx.doi.org/10.1016/j.acra.2005.08.024 ER - TY - JOUR T1 - Array-based proteomics: mapping of protein circuitries for diagnostics, prognostics, and therapy guidance in cancer AN - 19438747; 6708574 AB - The human proteome, due to the enormity of post-translational permutations that result in large numbers of isoforms, is much more complex than the genome and alterations in cancer can occur in ways that are not predictable by translational analysis alone. Proteomic analysis therefore represents a more direct way of investigating disease at the individual patient level. Furthermore, since most novel therapeutic targets are proteins, proteomic analysis potentially has a central role in patient care. At the same time, it is becoming clear that mapping entire networks rather than individual markers may be necessary for robust diagnostics as well as tailoring of therapy. Consequently, there is a need for high-throughput multiplexed proteomic techniques, with the capability of scanning multiple cases and analysing large numbers of endpoints. New types of protein arrays combined with advanced bioinformatics are currently being used to identify molecular signatures of individual tumours based on protein pathways and signalling cascades. It is envisaged that analysing the cellular "circuitry" of ongoing molecular networks will become a powerful clinical tool in patient management. JF - Journal of Pathology AU - Gulmann, C AU - Sheehan, Km AU - Kay, Ew AU - Petricoin III, Ef AD - NCI-FDA Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA, cgulmann@rcsi.ie Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 595 EP - 606 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 208 IS - 5 SN - 0022-3417, 0022-3417 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Translation KW - Peptide mapping KW - Tumors KW - Cancer KW - Computer programs KW - Scanning KW - Post-translation KW - Protein arrays KW - Bioinformatics KW - proteomics KW - Signal transduction KW - Gene mapping KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pathology&rft.atitle=Array-based+proteomics%3A+mapping+of+protein+circuitries+for+diagnostics%2C+prognostics%2C+and+therapy+guidance+in+cancer&rft.au=Gulmann%2C+C%3BSheehan%2C+Km%3BKay%2C+Ew%3BPetricoin+III%2C+Ef&rft.aulast=Gulmann&rft.aufirst=C&rft.date=2006-04-01&rft.volume=208&rft.issue=5&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pathology&rft.issn=00223417&rft_id=info:doi/10.1002%2Fpath.1958 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; Computer programs; Cancer; Gene mapping; Post-translation; Bioinformatics; Translation; Peptide mapping; Scanning; Signal transduction; Genomes; Tumors; Protein arrays DO - http://dx.doi.org/10.1002/path.1958 ER - TY - JOUR T1 - The MGED Ontology: a resource for semantics-based description of microarray experiments AN - 19438371; 6753451 AB - MOTIVATION: The generation of large amounts of microarray data and the need to share these data bring challenges for both data management and annotation and highlights the need for standards. MIAME specifies the minimum information needed to describe a microarray experiment and the Microarray Gene Expression Object Model (MAGE-OM) and resulting MAGE-ML provide a mechanism to standardize data representation for data exchange, however a common terminology for data annotation is needed to support these standards. RESULTS: Here we describe the MGED Ontology (MO) developed by the Ontology Working Group of the Microarray Gene Expression Data (MGED) Society. The MO provides terms for annotating all aspects of a microarray experiment from the design of the experiment and array layout, through to the preparation of the biological sample and the protocols used to hybridize the RNA and analyze the data. The MO was developed to provide terms for annotating experiments in line with the MIAME guidelines, i.e. to provide the semantics to describe a microarray experiment according to the concepts specified in MIAME. The MO does not attempt to incorporate terms from existing ontologies, e.g. those that deal with anatomical parts or developmental stages terms, but provides a framework to reference terms in other ontologies and therefore facilitates the use of ontologies in microarray data annotation. AVAILABILITY: The MGED Ontology version.1.2.0 is available as a file in both DAML and OWL formats at http://mged.sourceforge.net/ontologies/index.php. Release notes and annotation examples are provided. The MO is also provided via the NCICB's Enterprise Vocabulary System (http://nciterms.nci.nih.gov/NCIBrowser/Dictionary.do). CONTACT: Stoeckrtcbi.upenn.edu Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Whetzel, Patricia L AU - Parkinson, Helen AU - Causton, Helen C AU - Fan, Liju AU - Fostel, Jennifer AU - Fragoso, Gilberto AU - Game, Laurence AU - Heiskanen, Mervi AU - Morrison, Norman AU - Rocca-Serra, Philippe AU - Sansone, Susanna-Assunta AU - Taylor, Chris AU - White, Joseph AU - Stoeckert, Christian JJr AD - Center for Bioinformatics and Department of Genetics, University of Pennsylvania School of Medicine USA. European Bioinformatics Institute Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College Hammersmith Hospital Campus, DuCane Road, London W12 0NN, UK. Ontology Workshop LLC PO Box 182, Columbia, MD 21045-9998, USA. NIEHS PO Box 12233 MD F1-05, 111 Alexander Drive Research Triangle Park, NC 27709-2233, USA. NCICB, NCI Center for Bioinformatics 6116 Executive Boulevard, Rockville, MD 20852, USA. Department of Computer Science, Kilburn Building University of Manchester Oxford Road, Manchester M13 9PL, UK. Dana-Farber Cancer Institute 44 Binney Street, Boston, MA 02115, USA Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 866 EP - 873 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 7 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Developmental stages KW - Language KW - Bioinformatics KW - DNA microarrays KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=The+MGED+Ontology%3A+a+resource+for+semantics-based+description+of+microarray+experiments&rft.au=Whetzel%2C+Patricia+L%3BParkinson%2C+Helen%3BCauston%2C+Helen+C%3BFan%2C+Liju%3BFostel%2C+Jennifer%3BFragoso%2C+Gilberto%3BGame%2C+Laurence%3BHeiskanen%2C+Mervi%3BMorrison%2C+Norman%3BRocca-Serra%2C+Philippe%3BSansone%2C+Susanna-Assunta%3BTaylor%2C+Chris%3BWhite%2C+Joseph%3BStoeckert%2C+Christian+JJr&rft.aulast=Whetzel&rft.aufirst=Patricia&rft.date=2006-04-01&rft.volume=22&rft.issue=7&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Data processing; Gene expression; DNA microarrays; Bioinformatics; Language; RNA; Developmental stages; Models ER - TY - JOUR T1 - Measuring Tissue-Based Biomarkers by Immunochromatography Coupled with Reverse-Phase Lysate Microarray AN - 19437805; 6814710 AB - PURPOSE: There is a need for new technologies to study tissue-based biomarkers. The current gold standard, immunohistochemistry, is compromised by variability in tissue processing and observer bias. Reverse transcription-PCR (RT-PCR), immunocytochemistry, and reverse-phase lysate microarrays (RPM) are promising alternative technologies but have not yet been validated, or correlated, on the same patient-derived tissues. Furthermore, RPM is currently limited by time-consuming microdissection and low amounts of evaluable protein lysates. Experimental Design: Metastatic melanoma was surgically excised from 30 patients and macroscopically dissected from surrounding stroma. Each specimen was processed by formalin-fixation (immunohistochemistry), cytospin (immunocytochemistry), or disaggreagation and enrichment (RT-PCR and RPM). The latter protocol uses immunochromatography to remove hematopoetic-derived cells, thus enriching for melanoma cells. Each sample was measured for the expression of gp100 or MART-1 normalized to actin. RESULTS: Immunochromatography coupled with RPM (I-RPM) is reproducible (r greater than or equal to 0.70) and, for gp100, correlates strongly with immunohistochemistry and immunocytochemistry (r = 0.78 and 0.76, respectively) and moderately with transcript levels, measured by RT-PCR (r = 0.61). In contrast, for MART-1, I-RPM correlates strongly with transcript level (r = 0.78) but only moderately strong correlations are noted with immunohistochemistry and immunocytochemistry (r = 0.64 and 0.59, respectively). In general, transcript levels show only moderately strong correlations with immunohistochemistry and immunocytochemistry (r = 0.41-0.64). CONCLUSION: I-RPM is a promising technology for quantitative grading of tissue biomarkers; however, antigen-dependent correlations are noted. JF - Clinical Cancer Research AU - Romeo, Martin J AU - Wunderlich, John AU - Ngo, Lien AU - Rosenberg, Steven A AU - Steinberg, Seth M AU - Berman, David M AD - Authors' Affiliations: Laboratory of Pathology, Surgery Branch, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2463 EP - 2467 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 8 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Stroma KW - Immunocytochemistry KW - Transcription KW - DNA microarrays KW - biomarkers KW - Melanoma KW - Metastases KW - MART-1 antigen KW - Glycoprotein gp100 KW - Polymerase chain reaction KW - Actin KW - Immunohistochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19437805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Measuring+Tissue-Based+Biomarkers+by+Immunochromatography+Coupled+with+Reverse-Phase+Lysate+Microarray&rft.au=Romeo%2C+Martin+J%3BWunderlich%2C+John%3BNgo%2C+Lien%3BRosenberg%2C+Steven+A%3BSteinberg%2C+Seth+M%3BBerman%2C+David+M&rft.aulast=Romeo&rft.aufirst=Martin&rft.date=2006-04-01&rft.volume=12&rft.issue=8&rft.spage=2463&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Immunocytochemistry; Immunohistochemistry; biomarkers; Transcription; Polymerase chain reaction; DNA microarrays; MART-1 antigen; Glycoprotein gp100; Melanoma; Actin; Stroma; Metastases ER - TY - JOUR T1 - COCO-CL: hierarchical clustering of homology relations based on evolutionary correlations AN - 19434880; 6753439 AB - MOTIVATION: Determining orthology relations among genes across multiple genomes is an important problem in the post-genomic era. Identifying orthologous genes can not only help predict functional annotations for newly sequenced or poorly characterized genomes, but can also help predict new protein-protein interactions. Unfortunately, determining orthology relation through computational methods is not straightforward due to the presence of paralogs. Traditional approaches have relied on pairwise sequence comparisons to construct graphs, which were then partitioned into putative clusters of orthologous groups. These methods do not attempt to preserve the non-transitivity and hierarchic nature of the orthology relation. RESULTS: We propose a new method, COCO-CL, for hierarchical clustering of homology relations and identification of orthologous groups of genes. Unlike previous approaches, which are based on pairwise sequence comparisons, our method explores the correlation of evolutionary histories of individual genes in a more global context. COCO-CL can be used as a semi-independent method to delineate the orthology/paralogy relation for a refined set of homologous proteins obtained using a less-conservative clustering approach, or as a refiner that removes putative out-paralogs from clusters computed using a more inclusive approach. We analyze our clustering results manually, with support from literature and functional annotations. Since our orthology determination procedure does not employ a species tree to infer duplication events, it can be used in situations when the species tree is unknown or uncertain. CONTACT: jothiail.nih.gov, przytyckail.nih.gov Supplementary information: Supplementary materials are available at Bioinformatics online. JF - Bioinformatics AU - Jothi, Raja AU - Zotenko, Elena AU - Tasneem, Asba AU - Przytycka, Teresa M AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA. Department of Computer Science, University of Maryland College Park, MD 20742, USA. Beckman Institute, University of Illinois at Urbana-Champaign Urbana, IL 61801, USA Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 779 EP - 788 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 7 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Homology KW - Bioinformatics KW - Computer applications KW - Protein interaction KW - orthology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19434880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=COCO-CL%3A+hierarchical+clustering+of+homology+relations+based+on+evolutionary+correlations&rft.au=Jothi%2C+Raja%3BZotenko%2C+Elena%3BTasneem%2C+Asba%3BPrzytycka%2C+Teresa+M&rft.aulast=Jothi&rft.aufirst=Raja&rft.date=2006-04-01&rft.volume=22&rft.issue=7&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - orthology; Genomes; Homology; Bioinformatics; Protein interaction; Computer applications ER - TY - JOUR T1 - Pulsed High-Intensity Focused Ultrasound Enhances Thrombolysis in an in Vitro Model AN - 19433734; 6749938 AB - PURPOSE: To evaluate the use of pulsed high-intensity focused ultrasound exposures to improve tissue plasminogen activator (tPA)-mediated thrombolysis in an in vitro model. MATERIALS AND METHODS: All experimental work was compliant with institutional guidelines and HIPAA. Clots were formed by placing 1 mL of human blood in closed-off sections of pediatric Penrose tubes. Four experimental groups were evaluated: control (nontreated) clots, clots treated with pulsed high-intensity focused ultrasound only, clots treated with tPA only, and clots treated with pulsed high-intensity focused ultrasound plus tPA. The focused ultrasound exposures (real or sham) were followed by incubations of the clots in tPA with saline or in saline only. Thrombolysis was measured as the relative reduction in the mass of the clot. D-Dimer assays also were performed. Two additional experiments were performed and yielded dose-response curves for two exposure parameters: number of pulses per raster point and total acoustic power. Radiation force-induced displacements caused by focused ultrasound exposures were simulated in the clots. A Tukey-Kramer honestly significant difference test was performed for comparisons between all pairs of experimental groups. RESULTS: The clots treated with focused ultrasound alone did not show significant increases in thrombolysis compared with the control clots. The clots treated with focused ultrasound plus tPA showed a 50% ([30.2/20.1]/20.1) increase in the degree of thrombolysis compared with the clots treated with tPA only (P < .001), further corroborating the D-dimer assay results (P < .001). Additional experiments revealed how increasing both the number of pulses per raster point and the total acoustic power yielded corresponding increases in the thrombolysis rate. In the latter experiment, simulations performed at a range of power settings revealed a direct correlation between increased displacement and observed thrombolysis rate. CONCLUSION: The rate of tPA-mediated thrombolysis can be enhanced by using pulsed high-intensity focused ultrasound exposure in vitro. [copy ] RSNA, 2006 JF - Radiology AU - Frenkel, Victor AU - Oberoi, Jay AU - Stone, Michael J AU - Park, Melissa AU - Deng, Cheri AU - Wood, Bradford J AU - Neeman, Ziv AU - Horne, McDonald III AU - Li, King CP AD - Departments of Diagnostic Radiology (V.F., J.O., M.J.S., B.J.W., Z.N., K.C.P.L.) and Laboratory Medicine (M.P., M.H.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C657, Bethesda, MD 20892 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 86 EP - 93 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 239 IS - 1 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - thrombolysis KW - Radiation KW - Pediatrics KW - Acoustics KW - t-Plasminogen activator KW - Ultrasound KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19433734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Pulsed+High-Intensity+Focused+Ultrasound+Enhances+Thrombolysis+in+an+in+Vitro+Model&rft.au=Frenkel%2C+Victor%3BOberoi%2C+Jay%3BStone%2C+Michael+J%3BPark%2C+Melissa%3BDeng%2C+Cheri%3BWood%2C+Bradford+J%3BNeeman%2C+Ziv%3BHorne%2C+McDonald+III%3BLi%2C+King+CP&rft.aulast=Frenkel&rft.aufirst=Victor&rft.date=2006-04-01&rft.volume=239&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ultrasound; thrombolysis; t-Plasminogen activator; Acoustics; Models; Pediatrics; Radiation; Blood ER - TY - JOUR T1 - Chemical effects in biological systems (CEBS) object model for toxicology data, SysTox-OM: design and application AN - 19431839; 6753452 AB - MOTIVATION: The CEBS data repository is being developed to promote a systems biology approach to understand the biological effects of environmental stressors. CEBS will house data from multiple gene expression platforms (transcriptomics), protein expression and protein-protein interaction (proteomics), and changes in low molecular weight metabolite levels (metabolomics) aligned by their detailed toxicological context. The system will accommodate extensive complex querying in a user-friendly manner. CEBS will store toxicological contexts including the study design details, treatment protocols, animal characteristics and conventional toxicological endpoints such as histopathology findings and clinical chemistry measures. All of these data types can be integrated in a seamless fashion to enable data query and analysis in a biologically meaningful manner. RESULTS: An object model, the SysBio-OM (Xirasagar et al., 2004) has been designed to facilitate the integration of microarray gene expression, proteomics and metabolomics data in the CEBS database system. We now report SysTox-OM as an open source systems toxicology model designed to integrate toxicological context into gene expression experiments. The SysTox-OM model is comprehensive and leverages other open source efforts, namely, the Standard for Exchange of Nonclinical Data (http://www.cdisc.org/models/send/v2/index.html) which is a data standard for capturing toxicological information for animal studies and Clinical Data Interchange Standards Consortium (http://www.cdisc.org/models/sdtm/index.html) that serves as a standard for the exchange of clinical data. Such standardization increases the accuracy of data mining, interpretation and exchange. The open source SysTox-OM model, which can be implemented on various software platforms, is presented here. AVAILABILITY: A universal modeling language (UML) depiction of the entire SysTox-OM is available at http://cebs.niehs.nih.gov and the Rational Rose object model package is distributed under an open source license that permits unrestricted academic and commercial use and is available at http://cebs.niehs.nih.gov/cebsdownloads. Currently, the public toxicological data in CEBS can be queried via a web application based on the SysTox-OM at http://cebs.niehs.nih.gov. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Xirasagar, Sandhya AU - Gustafson, Scott F AU - Huang, Cheng-Cheng AU - Pan, Qinyan AU - Fostel, Jennifer AU - Boyer, Paul AU - Merrick, BAlex AU - Tomer, Kenneth B AU - Chan, Denny D AU - Yost, Kenneth JIII AU - Choi, Danielle AU - Xiao, Nianqing AU - Stasiewicz, Stanley AU - Bushel, Pierre AU - Waters, Michael D AD - Science Applications International Corporation 20201 Century Boulevard, 3rd Floor, Germantown, MD 20874, USA. NIEHS, National Center for Toxicogenomics PO Box 12233, Research Triangle Park, NC 27709, USA. Lockheed Martin Information Technologies PO Box 12233, Research Triangle Park, NC 27709, USA. Research Triangle Institute PO Box 12194, Research Triangle Park, NC 27709, USA, xirasagars@saic.com Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 874 EP - 882 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 7 SN - 1367-4803, 1367-4803 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Houses KW - Data processing KW - Metabolites KW - DNA microarrays KW - Models KW - Gene expression KW - Databases KW - Computer programs KW - Integration KW - Standardization KW - software KW - Language KW - proteomics KW - Bioinformatics KW - Protein interaction KW - metabolomics KW - X 24360:Metals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19431839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Chemical+effects+in+biological+systems+%28CEBS%29+object+model+for+toxicology+data%2C+SysTox-OM%3A+design+and+application&rft.au=Xirasagar%2C+Sandhya%3BGustafson%2C+Scott+F%3BHuang%2C+Cheng-Cheng%3BPan%2C+Qinyan%3BFostel%2C+Jennifer%3BBoyer%2C+Paul%3BMerrick%2C+BAlex%3BTomer%2C+Kenneth+B%3BChan%2C+Denny+D%3BYost%2C+Kenneth+JIII%3BChoi%2C+Danielle%3BXiao%2C+Nianqing%3BStasiewicz%2C+Stanley%3BBushel%2C+Pierre%3BWaters%2C+Michael+D&rft.aulast=Xirasagar&rft.aufirst=Sandhya&rft.date=2006-04-01&rft.volume=22&rft.issue=7&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Houses; Data processing; Metabolites; DNA microarrays; Models; Gene expression; Standardization; Integration; Computer programs; Databases; software; Language; Bioinformatics; proteomics; metabolomics; Protein interaction ER - TY - JOUR T1 - Evolutionary genomics of nucleo-cytoplasmic large DNA viruses AN - 17181284; 6842754 AB - A previous comparative-genomic study of large nuclear and cytoplasmic DNA viruses (NCLDVs) of eukaryotes revealed the monophyletic origin of four viral families: poxviruses, asfarviruses, iridoviruses, and phycodnaviruses [Iyer, L.M., Aravind, L., Koonin, E.V., 2001. Common origin of four diverse families of large eukaryotic DNA viruses. J. Virol. 75 (23), 11720-11734]. Here we update this analysis by including the recently sequenced giant genome of the mimiviruses and several additional genomes of iridoviruses, phycodnaviruses, and poxviruses. The parsimonious reconstruction of the gene complement of the ancestral NCLDV shows that it was a complex virus with at least 41 genes that encoded the replication machinery, up to four RNA polymerase subunits, at least three transcription factors, capping and polyadenylation enzymes, the DNA packaging apparatus, and structural components of an icosahedral capsid and the viral membrane. The phylogeny of the NCLDVs is reconstructed by cladistic analysis of the viral gene complements, and it is shown that the two principal lineages of NCLDVs are comprised of poxviruses grouped with asfarviruses and iridoviruses grouped with phycodnaviruses-mimiviruses. The phycodna-mimivirus grouping was strongly supported by several derived shared characters, which seemed to rule out the previously suggested basal position of the mimivirus [Raoult, D., Audic, S., Robert, C., Abergel, C., Renesto, P., Ogata, H., La Scola, B., Suzan, M., Claverie, J.M. 2004. The 1.2-megabase genome sequence of Mimivirus. Science 306 (5700), 1344-1350]. These results indicate that the divergence of the major NCLDV families occurred at an early stage of evolution, prior to the divergence of the major eukaryotic lineages. It is shown that subsequent evolution of the NCLDV genomes involved lineage-specific expansion of paralogous gene families and acquisition of numerous genes via horizontal gene transfer from the eukaryotic hosts, other viruses, and bacteria (primarily, endosymbionts and parasites). Amongst the expansions, there are multiple families of predicted virus-specific signaling and regulatory domains. Most NCLDVs have also acquired large arrays of genes related to ubiquitin signaling, and the animal viruses in particular have independently evolved several defenses against apoptosis and immune response, including growth factors and potential inhibitors of cytokine signaling. The mimivirus displays an enormous array of genes of bacterial provenance, including a representative of a new class of predicted papain-like peptidases. It is further demonstrated that a significant number of genes found in NCLDVs also have homologs in bacteriophages, although a vertical relationship between the NCLDVs and a particular bacteriophage group could not be established. On the basis of these observations, two alternative scenarios for the origin of the NCLDVs and other groups of large DNA viruses of eukaryotes are considered. One of these scenarios posits an early assembly of an already large DNA virus precursor from which various large DNA viruses diverged through an ongoing process of displacement of the original genes by xenologous or non-orthologous genes from various sources. The second scenario posits convergent emergence, on multiple occasions, of large DNA viruses from small plasmid-like precursors through independent accretion of similar sets of genes due to strong selective pressures imposed by their life cycles and hosts. JF - Virus Research AU - Iyer, L M AU - Balaji, S AU - Koonin, E V AU - Aravind, L AD - National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, aravind@ncbi.nlm.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 156 EP - 184 VL - 117 IS - 1 SN - 0168-1702, 0168-1702 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Phages KW - Parasites KW - Apoptosis KW - Endosymbionts KW - Nucleotide sequence KW - Polyadenylation KW - Gene families KW - DNA viruses KW - peptidase KW - DNA-directed RNA polymerase KW - Cytokines KW - Growth factors KW - Evolutionary genetics KW - genomics KW - Packaging KW - Ubiquitin KW - Phylogeny KW - Capsids KW - Replication KW - Enzymes KW - Eukaryotes KW - Gene transfer KW - Transcription factors KW - DNA KW - Immune response KW - cladistics KW - Evolution KW - Signal transduction KW - J 02310:Genetics & Taxonomy KW - G 07740:Evolution KW - N 14830:RNA KW - V 22010:Virus taxonomy & classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17181284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virus+Research&rft.atitle=Evolutionary+genomics+of+nucleo-cytoplasmic+large+DNA+viruses&rft.au=Iyer%2C+L+M%3BBalaji%2C+S%3BKoonin%2C+E+V%3BAravind%2C+L&rft.aulast=Iyer&rft.aufirst=L&rft.date=2006-04-01&rft.volume=117&rft.issue=1&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Virus+Research&rft.issn=01681702&rft_id=info:doi/10.1016%2Fj.virusres.2006.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Genomes; Parasites; Apoptosis; Endosymbionts; Nucleotide sequence; Polyadenylation; Gene families; peptidase; DNA viruses; DNA-directed RNA polymerase; Cytokines; genomics; Evolutionary genetics; Growth factors; Ubiquitin; Packaging; Capsids; Phylogeny; Replication; Enzymes; Eukaryotes; Gene transfer; Transcription factors; DNA; Immune response; cladistics; Evolution; Signal transduction DO - http://dx.doi.org/10.1016/j.virusres.2006.01.009 ER - TY - JOUR T1 - The role of the endocannabinoid system in the control of energy homeostasis AN - 17178677; 6852878 AB - The endocannabinoid system has recently emerged as an important regulator of energy homeostasis, involved in the control of both appetite and peripheral fat metabolism. We briefly review current understanding of the possible sites of action and cellular mechanisms involved in the central appetitive and peripheral metabolic effects of endocannabinoids. Studies in our laboratory, using leptin-deficient obese rodents and CB1 cannabinoid receptor (CB1)-deficient mice, have indicated that endocannabinoids acting via CB1 are involved in the hunger-induced increase in food intake and are negatively regulated by leptin in brain areas involved in appetite control, including the hypothalamus, limbic forebrain and amygdala. CB1 super(-/-) mice are lean and are resistant to diet-induced obesity (DIO) despite similar energy intake to wild-type mice with DIO, suggesting that CB1 regulation of body weight involves additional peripheral targets. Such targets appear to include both adipose tissue and the liver. CB1 expressed in adipocytes has been implicated in the control of adiponectin secretion and lipoprotein lipase activity. Recent findings indicate that both endocannabinoids and CB1 are present in the liver and are upreguiated in DIO. CB1 stimulation increases de novo hepatic lipogenesis through activation of the fatty acid biosynthetic pathway. Components of this pathway are also expressed in the hypothalamus where they have been implicated in the regulation of appetite. The fatty acid biosynthetic pathway may thus represent a common molecular target for the central appetitive and peripheral metabolic effects of endocannabinoids. JF - International Journal of Obesity AU - Osei-Hyiaman, D AU - Harvey-White, J AU - Batkai, S AU - Kunos, G AD - NIAAA/NIH, 5625 Fishers Lane, MSC-9413, Bethesda, MD 20892-9413 USA, gkunos@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - S33 EP - S38 VL - 30 SN - 0307-0565, 0307-0565 KW - Physical Education Index KW - Obesity KW - Arousal KW - Animal subjects KW - Lipids KW - Brain KW - Diet (weight control) KW - Enzymes KW - Hormones KW - Liver KW - Stimuli KW - Fats KW - Metabolism KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17178677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=The+role+of+the+endocannabinoid+system+in+the+control+of+energy+homeostasis&rft.au=Osei-Hyiaman%2C+D%3BHarvey-White%2C+J%3BBatkai%2C+S%3BKunos%2C+G&rft.aulast=Osei-Hyiaman&rft.aufirst=D&rft.date=2006-04-01&rft.volume=30&rft.issue=&rft.spage=S33&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0803276 LA - English DB - Physical Education Index N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Arousal; Lipids; Animal subjects; Diet (weight control); Brain; Liver; Enzymes; Fats; Stimuli; Hormones; Metabolism DO - http://dx.doi.org/10.1038/sj.ijo.0803276 ER - TY - JOUR T1 - Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon- gamma -dependent signaling AN - 17167448; 6836959 AB - Mendelian defects in interferon- gamma (IFN- gamma ) signaling most commonly lead to infection with nontuberculous mycobacteria. Mutations have been identified in the genes encoding IFN- gamma -receptor-1, IFN- gamma -receptor-2 and Stat-1. Partial and complete deficiencies in signaling are found, leading to parallel clinical, pathological, and cellular phenotypes. These rare defects have led to better molecular and mechanistic understanding of the role of IFN- gamma in the human immune system. JF - Microbes and Infection AU - Haverkamp, M H AU - Van Dissel, JT AU - Holland, S M AD - Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef, Postbus 9600, 2300 RC Leiden, The Netherlands, mhaverkamp@niaid.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1157 EP - 1166 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 8 IS - 4 SN - 1286-4579, 1286-4579 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interferon- gamma KW - Interferon- gamma receptor KW - Stat-1 KW - Mycobacterium KW - Mutation KW - gamma -Interferon KW - Genetic factors KW - Stat1 protein KW - Immune system KW - Immunity KW - Infection KW - Signal transduction KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17167448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Human+host+genetic+factors+in+nontuberculous+mycobacterial+infection%3A+lessons+from+single+gene+disorders+affecting+innate+and+adaptive+immunity+and+lessons+from+molecular+defects+in+interferon-+gamma+-dependent+signaling&rft.au=Haverkamp%2C+M+H%3BVan+Dissel%2C+JT%3BHolland%2C+S+M&rft.aulast=Haverkamp&rft.aufirst=M&rft.date=2006-04-01&rft.volume=8&rft.issue=4&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2005.10.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Genetic factors; Stat1 protein; Immune system; Immunity; Infection; Mutation; Signal transduction; Mycobacterium DO - http://dx.doi.org/10.1016/j.micinf.2005.10.029 ER - TY - JOUR T1 - Using Electronic Diaries to Examine Physical Activity and Other Health Behaviors of Adults Age 50+ AN - 17151243; 6817148 AB - This pilot investigation used portable electronic diaries to assess the physical activity and other health behaviors of 20 adults age 50+ (mean age = 61 years). Study aims were to examine whether computerized cognitive-behavioral strategies could increase adherence to the assessments, the acceptability of electronic diaries to assess everyday health, and the relationship between computerized physical activity assessments with a standardized physical activity measure. Although approximately two thirds of participants had never used an electronic diary, results indicated that a large majority (83%) reported enjoying the use of the electronic diaries, and most (72%) reported enjoying answering all of the health questions. The cognitive-behavioral strategies employed did not enhance assessment adherence, but electronic-diary-based activity levels corresponded more strongly with the poststudy standardized activity measure than the baseline standardized measure, providing evidence of temporal convergence. Findings suggest that the use of portable electronic technology in physical activity assessment of middle-aged and older adults deserves further study. JF - Journal of Aging and Physical Activity AU - Atienza, A A AU - Oliveira, B AU - Fogg, B J AU - King, A C AD - Health Promotion Research Branch, National Cancer Institute, Bethesda, MD 20982-7335, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 192 EP - 202 VL - 14 IS - 2 SN - 1063-8652, 1063-8652 KW - Physical Education Index KW - Evaluation KW - Strategy KW - Compliance KW - Gerontology KW - Health (behavior) KW - Health KW - Exercise KW - Adults KW - Technology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17151243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Physical+Activity&rft.atitle=Using+Electronic+Diaries+to+Examine+Physical+Activity+and+Other+Health+Behaviors+of+Adults+Age+50%2B&rft.au=Atienza%2C+A+A%3BOliveira%2C+B%3BFogg%2C+B+J%3BKing%2C+A+C&rft.aulast=Atienza&rft.aufirst=A&rft.date=2006-04-01&rft.volume=14&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Physical+Activity&rft.issn=10638652&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Evaluation; Compliance; Strategy; Gerontology; Health (behavior); Health; Adults; Exercise; Technology ER - TY - JOUR T1 - Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation AN - 17147485; 6810667 AB - Helicobacter pylori vacuolating cytotoxin, VacA, which causes vacuolation of gastric epithelial cells and other types of cultured cells, is known to stimulate apoptosis via a mitochondria-dependent pathway. In the present study, we examined the mechanisms of VacA-induced mitochondrial damage. Intracellular VacA localization was monitored by immunostaining and confocal microscopy; in AZ-521 cells in which cytochrome c release was stimulated, most of VacA was localized to vacuoles rather than mitochondria. VacA reduced the membrane potential of isolated mitochondria without inducing cytochrome c release, suggesting that it did not act directly to induce cytochrome c release from mitochondria and that in intact cells, VacA-induced cytochrome c release involved apoptosis-related factor(s), such as a proapoptotic Bcl-2 family protein. In agreement, flow cyto-metric analyses using antibodies specific for activated Bax revealed that intracellular Bax was activated by VacA in a concentration- and time-dependent manner. Using active form-specific antibodies, we also observed that the Bcl-2 family protein, Bak, was activated. By confocal microscopy, Bax and Bak were activated in AZ-521 cells in which cyto-chrome c release was induced by VacA. In addition, small interfering RNA-induced silencing of the bax gene resulted in reduction of VacA-stimulated cytochrome c release, consistent with a contribution of VacA-induced Bax activation to cytochrome c release. NH sub(4)Cl enhanced both VacA-induced vacuolation and Bax activation, whereas Bax activation was not inhibited by bafilomycin A1, which inhibited vacuolation caused by VacA. These results suggest that VacA acts through different signaling pathways to induce apoptosis via Bax activation, independent of vacuolation. JF - Journal of Biological Chemistry AU - Yamasaki, Eiki AU - Wada, Akihiro AU - Kumatori, Atsushi AU - Nakagawa, Ichiro AU - Funao, Junko AU - Nakayama, Masaaki AU - Hisatsune, Junzo AU - Kimura, Miyuki AU - Moss, Joel AU - Hirayama, Toshiya AD - PRESTO, Japan Science and Technology Corporation, Saitama 332-0012, Japan, the Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan, the Division of Medical Science, Department of Disaster Prevention System, Faculty of Risk and Crisis Management, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan, the Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan, the Department of Medical Technology, Faculty of Health Sciences, Okayama University Medical School, Okayama 700-8558, Japan, and the Pulmonary-Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 11250 EP - 11259 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 16 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Epithelial cells KW - Apoptosis KW - Cytotoxins KW - Mitochondria KW - Antibodies KW - Cytochrome c KW - Bax protein KW - Confocal microscopy KW - Vacuoles KW - Bcl-2 protein KW - Signal transduction KW - Membrane potential KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Helicobacter+pylori+Vacuolating+Cytotoxin+Induces+Activation+of+the+Proapoptotic+Proteins+Bax+and+Bak%2C+Leading+to+Cytochrome+c+Release+and+Cell+Death%2C+Independent+of+Vacuolation&rft.au=Yamasaki%2C+Eiki%3BWada%2C+Akihiro%3BKumatori%2C+Atsushi%3BNakagawa%2C+Ichiro%3BFunao%2C+Junko%3BNakayama%2C+Masaaki%3BHisatsune%2C+Junzo%3BKimura%2C+Miyuki%3BMoss%2C+Joel%3BHirayama%2C+Toshiya&rft.aulast=Yamasaki&rft.aufirst=Eiki&rft.date=2006-04-01&rft.volume=281&rft.issue=16&rft.spage=11250&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Antibodies; Apoptosis; Cytochrome c; Cytotoxins; Bax protein; Vacuoles; Confocal microscopy; Mitochondria; Bcl-2 protein; Membrane potential; Signal transduction; Helicobacter pylori ER - TY - JOUR T1 - Recent Tanning Bed Use: A Risk Factor for Melanoma AN - 17147222; 6809060 AB - BACKGROUND: Individuals at increased risk of melanoma should use sun-protective measures to decrease their risk of developing melanoma. OBSERVATION: We report a case of a 39-year-old patient with a CDKN2A mutation who developed 3 primary melanomas within a few years of initiating tanning bed use. CONCLUSION: Intense UV exposure as an adult likely contributed to the development of additional primary melanomas in this individual. JF - Archives of Dermatology AU - Buckel, Tamy BH AU - Goldstein, Alisa M AU - Fraser, Mary C AU - Rogers, Barbara AU - Tucker, Margaret A AD - Division of Cancer Prevention and Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 485 EP - 488 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 142 IS - 4 SN - 0003-987X, 0003-987X KW - tanning beds KW - Health & Safety Science Abstracts; Risk Abstracts KW - Consumer products KW - Ultraviolet radiation KW - Cancer KW - R2 23020:Technological risks KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Dermatology&rft.atitle=Recent+Tanning+Bed+Use%3A+A+Risk+Factor+for+Melanoma&rft.au=Buckel%2C+Tamy+BH%3BGoldstein%2C+Alisa+M%3BFraser%2C+Mary+C%3BRogers%2C+Barbara%3BTucker%2C+Margaret+A&rft.aulast=Buckel&rft.aufirst=Tamy&rft.date=2006-04-01&rft.volume=142&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Archives+of+Dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Consumer products; Ultraviolet radiation; Cancer ER - TY - JOUR T1 - Clinical and Laboratory Features of the Nocardia spp. Based on Current Molecular Taxonomy AN - 17144357; 6813795 AB - The recent explosion of newly described species of Nocardia results from the impact in the last decade of newer molecular technology, including PCR restriction enzyme analysis and 16S rRNA sequencing. These molecular techniques have revolutionized the identification of the nocardiae by providing rapid and accurate identification of recognized nocardiae and, at the same time, revealing new species and a number of yet-to-be-described species. There are currently more than 30 species of nocardiae of human clinical significance, with the majority of isolates being N. nova complex, N. abscessus, N. transvalensis complex, N. farcinica, N. asteroides type VI (N. cyriacigeorgica), and N. brasiliensis. These species cause a wide variety of diseases and have variable drug susceptibilities. Accurate identification often requires referral to a reference laboratory with molecular capabilities, as many newer species are genetically distinct from established species yet have few or no distinguishing phenotypic characteristics. Correct identification is important in deciding the clinical relevance of a species and in the clinical management and treatment of patients with nocardial disease. This review characterizes the currently known pathogenic species of Nocardia, including clinical disease, drug susceptibility, and methods of identification. JF - Clinical Microbiology Reviews AU - Brown-Elliott, Barbara A AU - Brown, June M AU - Conville, Patricia S AU - Wallace, Richard JJr AD - University of Texas Health Center, Department of Microbiology, Tyler, Texas. Centers for Disease Control and Prevention, Division of Bacterial and Mycotic Diseases, Atlanta, Georgia. National Institutes of Health, Department of Laboratory Medicine, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 259 EP - 282 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 19 IS - 2 SN - 0893-8512, 0893-8512 KW - Microbiology Abstracts B: Bacteriology KW - Reviews KW - Polymerase chain reaction KW - Enzymes KW - Taxonomy KW - Nocardia KW - Drugs KW - rRNA 16S KW - New species KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17144357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Clinical+and+Laboratory+Features+of+the+Nocardia+spp.+Based+on+Current+Molecular+Taxonomy&rft.au=Brown-Elliott%2C+Barbara+A%3BBrown%2C+June+M%3BConville%2C+Patricia+S%3BWallace%2C+Richard+JJr&rft.aulast=Brown-Elliott&rft.aufirst=Barbara&rft.date=2006-04-01&rft.volume=19&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Reviews; Enzymes; Polymerase chain reaction; Taxonomy; rRNA 16S; Drugs; New species; Nocardia ER - TY - JOUR T1 - NMR study of the tetrameric KcsA potassium channel in detergent micelles AN - 17131490; 6752637 AB - Nuclear magnetic resonance (NMR) studies of large membrane-associated proteins are limited by the difficulties in preparation of stable protein-detergent mixed micelles and by line broadening, which is typical of these macroassemblies. We have used the 68-kDa homotetrameric KcsA, a thermostable N-terminal deletion mutant of a bacterial potassium channel from Streptomyces lividans, as a model system for applying NMR methods to membrane proteins. Optimization of measurement conditions enabled us to perform the backbone assignment of KcsA in SDS micelles and establish its secondary structure, which was found to closely agree with the KcsA crystal structure. The C-terminal cytoplasmic domain, absent in the original structure, contains a 14-residue helix that could participate in tetramerization by forming an intersubunit four-helix bundle. A quantitative estimate of cross- relaxation between detergent and KcsA backbone amide protons, together with relaxation and light scattering data, suggests SDS-KcsA mixed micelles form an oblate spheroid with approximately 180 SDS molecules per channel. K super(+) ions bind to the micelle-solubilized channel with a K sub(D) of 3 plus or minus 0.5 mM, resulting in chemical shift changes in the selectivity filter. Related pH-induced changes in chemical shift along the "outer" transmembrane helix and the cytoplasmic membrane interface hint at a possible structural explanation for the observed pH-gating of the potassium channel. JF - Protein Science AU - Chill, Jordan H AU - Louis, John M AU - Miller, Christopher AU - Bax, Ad AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 684 EP - 698 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 15 IS - 4 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Ions KW - Deletion mutant KW - Protons KW - Detergents KW - Secondary structure KW - Light scattering KW - Potassium KW - Membrane proteins KW - Protein structure KW - Filters KW - Micelles KW - Streptomyces lividans KW - Cytoplasmic membranes KW - Sodium lauryl sulfate KW - Crystal structure KW - N.M.R. KW - spheroids KW - Potassium channels KW - amides KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17131490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=NMR+study+of+the+tetrameric+KcsA+potassium+channel+in+detergent+micelles&rft.au=Chill%2C+Jordan+H%3BLouis%2C+John+M%3BMiller%2C+Christopher%3BBax%2C+Ad&rft.aulast=Chill&rft.aufirst=Jordan&rft.date=2006-04-01&rft.volume=15&rft.issue=4&rft.spage=684&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ions; Deletion mutant; Detergents; Protons; Secondary structure; Light scattering; Potassium; Membrane proteins; Filters; Protein structure; Micelles; Crystal structure; Sodium lauryl sulfate; Cytoplasmic membranes; N.M.R.; spheroids; Potassium channels; amides; Streptomyces lividans ER - TY - JOUR T1 - Systemic Immunization with an ALVAC-HIV-1/Protein Boost Vaccine Strategy Protects Rhesus Macaques from CD4 super(+) T-Cell Loss and Reduces both Systemic and Mucosal Simian-Human Immunodeficiency Virus SHIV sub(KU2) RNA Levels AN - 17129242; 6749132 AB - Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombinant vaccines expressing Gag, Pol, and gp120 (vCP250) or Gag, Pol, and gp160 (vCP1420) in a prime-boost protocol with their homologous vaccine native Env proteins. The relative efficacy was measured against a high-dose mucosal exposure to the pathogenic neutralization-resistant variant SHIV sub(KU2) (simian-human immunodeficiency virus). Systemic immunization with both vaccine regimens decreased viral load levels not only in blood but unexpectedly also in mucosal sites and protected macaques from peripheral CD4 super(+) T-cell loss. This protective effect was stronger when the gp120 antigen was included in the vaccine. Inclusion of recombinant Tat protein in the boosting phase along with the Env protein did not contribute further to the preservation of CD4 super(+) T cells. Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques. JF - Journal of Virology AU - Pal, Ranajit AU - Venzon, David AU - Santra, Sampa AU - Kalyanaraman, Vaniambadi S AU - Montefiori, David C AU - Hocker, Lindsey AU - Hudacik, Lauren AU - Rose, Nicolas AU - Nacsa, Janos AU - Edghill-Smith, Yvette AU - Moniuszko, Marcin AU - Hel, Zdenek AU - Belyakov, Igor M AU - Berzofsky, Jay A AU - Parks, Robyn Washington AU - Markham, Phillip D AU - Letvin, Norman L AU - Tartaglia, Jim AU - Franchini, Genoveffa AD - Advanced BioScience Laboratories, Inc., 5510 Nicholson Lane, Kensington, Maryland 20895. Biostatistics and Data Management Section, National Cancer Institute, 6116 Executive Boulevard, MSC 8325, Suite 702, Bethesda, Maryland 20892. Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P. O. Box 15732, Boston, Massachusetts 02215. Department of Surgery, Center for AIDS Research, Duke University Medical Center, Box 2926, Durham, North Carolina 27710. Animal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, 41/D804, Bethesda, Maryland 20892. Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701. Department of Allergology and Internal Diseases, Medical University of Bialystok, ul. Sklodowskiej 24 A, 15-276, Bialystok, Poland. Department of Pathology, Center for AIDS Research, University of Alabama at Birmingham, 619 19th Street South, Room SW-W286, Birmingham, Alabama 35249. Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 3732 EP - 3742 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 8 SN - 0022-538X, 0022-538X KW - HIV-1 KW - Rhesus monkey KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Simian/human immunodeficiency virus KW - RNA viruses KW - CD4 antigen KW - glycoprotein gp160 KW - Lymphocytes T KW - Mucosal immunity KW - Tat protein KW - Replication KW - Immunization KW - RNA KW - Immunogenicity KW - Preservation KW - Vaccines KW - Glycoprotein gp120 KW - Envelope protein KW - Human immunodeficiency virus 1 KW - Macaca mulatta KW - Blood KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - V 22003:AIDS: Immunological aspects KW - W 30965:Miscellaneous, Reviews KW - N 14030:DNA: biosynthesis, repair & replication cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17129242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Systemic+Immunization+with+an+ALVAC-HIV-1%2FProtein+Boost+Vaccine+Strategy+Protects+Rhesus+Macaques+from+CD4+super%28%2B%29+T-Cell+Loss+and+Reduces+both+Systemic+and+Mucosal+Simian-Human+Immunodeficiency+Virus+SHIV+sub%28KU2%29+RNA+Levels&rft.au=Pal%2C+Ranajit%3BVenzon%2C+David%3BSantra%2C+Sampa%3BKalyanaraman%2C+Vaniambadi+S%3BMontefiori%2C+David+C%3BHocker%2C+Lindsey%3BHudacik%2C+Lauren%3BRose%2C+Nicolas%3BNacsa%2C+Janos%3BEdghill-Smith%2C+Yvette%3BMoniuszko%2C+Marcin%3BHel%2C+Zdenek%3BBelyakov%2C+Igor+M%3BBerzofsky%2C+Jay+A%3BParks%2C+Robyn+Washington%3BMarkham%2C+Phillip+D%3BLetvin%2C+Norman+L%3BTartaglia%2C+Jim%3BFranchini%2C+Genoveffa&rft.aulast=Pal&rft.aufirst=Ranajit&rft.date=2006-04-01&rft.volume=80&rft.issue=8&rft.spage=3732&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Simian/human immunodeficiency virus; Macaca mulatta; Vaccines; Immunization; CD4 antigen; Lymphocytes T; Glycoprotein gp120; Envelope protein; Immunogenicity; Replication; Blood; Mucosal immunity; RNA viruses; RNA; Tat protein; glycoprotein gp160; Preservation ER - TY - JOUR T1 - Translating accelerometer counts into energy expenditure: advancing the quest AN - 17126623; 6753948 JF - Journal of Applied Physiology AU - Troiano, Richard P AD - Applied Research Program , Risk Factor Monitoring and Methods Branch , National Cancer Institute , National Institutes of Health , Bethesda, Maryland, troianor@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1107 EP - 1108 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 100 IS - 4 SN - 8750-7587, 8750-7587 KW - Physical Education Index KW - Energy cost KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17126623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Physiology&rft.atitle=Translating+accelerometer+counts+into+energy+expenditure%3A+advancing+the+quest&rft.au=Troiano%2C+Richard+P&rft.aulast=Troiano&rft.aufirst=Richard&rft.date=2006-04-01&rft.volume=100&rft.issue=4&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Physiology&rft.issn=87507587&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Energy cost ER - TY - JOUR T1 - A Prospective Study of Psychological Predictors of Body Fat Gain Among Children at High Risk for Adult Obesity AN - 17125781; 6749662 AB - OBJECTIVE. Limited data suggest that psychological factors, including binge eating, dieting, and depressive symptoms, may predispose children to excessive weight gain. We investigated the relationship between baseline psychological measures and changes in body fat (measured with dual-energy x-ray absorptiometry) over time among children thought to be at high risk for adult obesity. METHODS. A cohort study of a convenience sample of children (age: 6-12 years) recruited from Washington, DC, and its suburbs was performed. Subjects were selected to be at increased risk for adult obesity, either because they were overweight when first examined or because their parents were overweight. Children completed questionnaires at baseline that assessed dieting, binge eating, disordered eating attitudes, and depressive symptoms; they underwent measurements of body fat mass at baseline and annually for an average of 4.2 years (SD: 1.8 years). RESULTS. Five hundred sixty-eight measurements were obtained between July 1996 and December 2004, for 146 children. Both binge eating and dieting predicted increases in body fat. Neither depressive symptoms nor disturbed eating attitudes served as significant predictors. Children who reported binge eating gained, on average, 15% more fat mass, compared with children who did not report binge eating. CONCLUSIONS. Children's reports of binge eating and dieting were salient predictors of gains in fat mass during middle childhood among children at high risk for adult obesity. Interventions targeting disordered eating behaviors may be useful in preventing excessive fat gain in this high-risk group. JF - Pediatrics AU - Tanofsky-Kraff, Marian AU - Cohen, Marc L AU - Yanovski, Susan Z AU - Cox, Christopher AU - Theim, Kelly R AU - Keil, Margaret AU - Reynolds, James C AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch. Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1203 EP - 1209 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 4 SN - 0031-4005, 0031-4005 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Measurement KW - Age KW - Eating disorders KW - Psychology KW - Pediatrics KW - Diet (weight control) KW - Surveys KW - Adults KW - Children KW - X-Ray KW - Attitudes KW - R2 23110:Psychological aspects KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17125781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=A+Prospective+Study+of+Psychological+Predictors+of+Body+Fat+Gain+Among+Children+at+High+Risk+for+Adult+Obesity&rft.au=Tanofsky-Kraff%2C+Marian%3BCohen%2C+Marc+L%3BYanovski%2C+Susan+Z%3BCox%2C+Christopher%3BTheim%2C+Kelly+R%3BKeil%2C+Margaret%3BReynolds%2C+James+C%3BYanovski%2C+Jack+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2006-04-01&rft.volume=117&rft.issue=4&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - X-Ray; Measurement; Obesity; Age; Attitudes; Pediatrics; Psychology; Eating disorders; Diet (weight control); Surveys; Adults; Children ER - TY - JOUR T1 - Swimming Pool Drownings Among US Residents Aged 5-24 Years: Understanding Racial/Ethnic Disparities AN - 17125715; 6750240 AB - OBJECTIVE: We examined circumstances surrounding swimming pool drownings among US residents aged 5 to 24 years to understand why Black males and other racial/ethnic groups have high drowning rates. METHODS: We obtained data about drowning deaths in the United States (1995-1998) from death certificates, medical examiner reports, and newspaper clippings collected by the US Consumer Product Safety Commission. RESULTS: During the study period, 678 US residents aged 5 to 24 years drowned in pools. Seventy-five percent were male, 47% were Black, 33% were White, and 12% were Hispanic. Drowning rates were highest among Black males, and this increased risk persisted after we controlled for income. The majority of Black victims (51%) drowned in public pools, the majority of White victims (55%) drowned in residential pools, and the majority of Hispanic victims (35%) drowned in neighborhood pools (e.g., an apartment complex pool). Foreign-born males also had an increased risk for drowning compared with American-born males. CONCLUSIONS: Targeted interventions are needed to reduce the incidence of swimming pool drownings across racial/ethnic groups, particularly adult supervision at public pools. JF - American Journal of Public Health AU - Saluja, Gitanjali AU - Brenner, Ruth A AU - Trumble, Ann C AU - Smith, Gordon S AU - Schroeder, Tom AU - Cox, Christopher AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 728 EP - 733 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 4 SN - 0090-0036, 0090-0036 KW - Health & Safety Science Abstracts; Physical Education Index; Risk Abstracts KW - Newspapers KW - Mortality KW - Death KW - Drowning KW - Blacks KW - Safety KW - Intervention KW - Adults KW - Public health KW - USA KW - Hispanic Americans KW - Recreation areas KW - Swimming pools KW - Supervision KW - drowning KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17125715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Swimming+Pool+Drownings+Among+US+Residents+Aged+5-24+Years%3A+Understanding+Racial%2FEthnic+Disparities&rft.au=Saluja%2C+Gitanjali%3BBrenner%2C+Ruth+A%3BTrumble%2C+Ann+C%3BSmith%2C+Gordon+S%3BSchroeder%2C+Tom%3BCox%2C+Christopher&rft.aulast=Saluja&rft.aufirst=Gitanjali&rft.date=2006-04-01&rft.volume=96&rft.issue=4&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Newspapers; Death; Hispanic Americans; Drowning; Blacks; Safety; Intervention; Swimming pools; Adults; Supervision; Ethnic groups; Public health; Mortality; Recreation areas; drowning; USA ER - TY - JOUR T1 - CpG Oligodeoxynucleotides Protect Newborn Mice from a Lethal Challenge with the Neurotropic Tacaribe Arenavirus AN - 17122492; 6748803 AB - The innate immune system is key to limiting the early spread of most pathogens and directing the development of Ag-specific immunity. Recently, a number of synthetic molecules that activate the innate immune system by stimulating TLRs have been identified. Among them, synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs (CpG ODNs) were shown to activate TLR9-bearing B cells, macrophages, and dendritic cells to induce a strong proinflammatory milieu and a type 1-biased immune response that protects mice from a variety of parasitic, bacterial, and viral infections. Although the protective effect of CpG ODN in adult mice was well established, its effectiveness in neonates, which have lower numbers of dendritic, B, and T cells and tend to favor Th2 responses, was unclear. This study uses the New World arenavirus Tacaribe, a neurotropic pathogen that is lethal in newborn mice, to explore the effectiveness of TLR-mediated innate immune responses. Neonatal BALB/c mice treated with CpG ODN at the time of infection had reduced viral load (p < 0.01) and increased survival (52%, p < 0.001 i.p.; 36%, p < 0.05 intranasally). Protection was achieved in mice treated no later than 3 days postchallenge and appears to be mediated by an increase in Ag-specific Abs (IgG and IgM) and to require inducible NO synthase expression and NO production. To our knowledge, this is the first study assessing the mechanisms by which CpG ODN can protect mice from a neurotropic viral infection. JF - Journal of Immunology AU - Pedras-Vasconcelos, Joao A AU - Goucher, David AU - Puig, Montserrat AU - Tonelli, Leonardo H AU - Wang, Vivian AU - Ito, Shuichi AU - Verthelyi, Daniela AD - Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Federal Drug Administration, Bethesda, MD 20892. Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892. Division of Viral Products, Center for Biologics Evaluation and Research, Federal Drug Administration, Rockville, MD 20852 Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 4940 EP - 4949 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 8 SN - 0022-1767, 0022-1767 KW - mice KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Macrophages KW - Lymphocytes B KW - Immune system KW - Helper cells KW - Survival KW - Pathogens KW - CpG islands KW - Infection KW - Oligonucleotides KW - Arenavirus KW - Inflammation KW - Nitric-oxide synthase KW - Dendritic cells KW - Lymphocytes T KW - Immunoglobulin G KW - Nitric oxide KW - Neonates KW - Immunoglobulin M KW - V 22099:Immune response & immune mechanisms KW - J 02350:Immunology KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17122492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CpG+Oligodeoxynucleotides+Protect+Newborn+Mice+from+a+Lethal+Challenge+with+the+Neurotropic+Tacaribe+Arenavirus&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BGoucher%2C+David%3BPuig%2C+Montserrat%3BTonelli%2C+Leonardo+H%3BWang%2C+Vivian%3BIto%2C+Shuichi%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2006-04-01&rft.volume=176&rft.issue=8&rft.spage=4940&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Lymphocytes B; Helper cells; Immune system; Survival; CpG islands; Pathogens; Infection; Oligonucleotides; Inflammation; Nitric-oxide synthase; Dendritic cells; Immunoglobulin G; Lymphocytes T; Nitric oxide; Neonates; Immunoglobulin M; Arenavirus ER - TY - JOUR T1 - Molecular Characterization of Subject-Specific Oral Microflora during Initial Colonization of Enamel AN - 17121761; 6750764 AB - The initial microbial colonization of tooth surfaces is a repeatable and selective process, with certain bacterial species predominating in the nascent biofilm. Characterization of the initial microflora is the first step in understanding interactions among community members that shape ensuing biofilm development. Using molecular methods and a retrievable enamel chip model, we characterized the microbial diversity of early dental biofilms in three subjects. A total of 531 16S rRNA gene sequences were analyzed, and 97 distinct phylotypes were identified. Microbial community composition was shown to be statistically different among subjects. In all subjects, however, 4-h and 8-h communities were dominated by Streptococcus spp. belonging to the Streptococcus oralis/Streptococcus mitis group. Other frequently observed genera (comprising at least 5% of clone sequences in at least one of the six clone libraries) were Actinomyces, Gemella, Granulicatella, Neisseria, Prevotella, Rothia, and VEILLONELLA: Fluorescence in situ hybridization (FISH) confirmed that the proportion of Streptococcus sp. sequences in the clone libraries coincided with the proportion of streptococcus probe-positive organisms on the chip. FISH also revealed that, in the undisturbed plaque, not only Streptococcus spp. but also the rarer Prevotella spp. were usually seen in small multigeneric clusters of cells. This study shows that the initial dental plaque community of each subject is unique in terms of diversity and composition. Repetitive and distinctive community composition within subjects suggests that the spatiotemporal interactions and ecological shifts that accompany biofilm maturation also occur in a subject-dependent manner. JF - Applied and Environmental Microbiology AU - Diaz, Patricia I AU - Chalmers, Natalia I AU - Rickard, Alexander H AU - Kong, Colin AU - Milburn, Craig L AU - Palmer, Robert J, Jr AU - Kolenbrander, Paul E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland. Department of Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2837 EP - 2848 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 4 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Ecology Abstracts KW - Prevotella KW - Teeth KW - Molecular modelling KW - Neisseria KW - Dental plaque KW - Colonization KW - Community composition KW - Oral microflora KW - Veillonella KW - Biofilms KW - Streptococcus mitis KW - rRNA 16S KW - Actinomyces KW - Dental enamel KW - Streptococcus oralis KW - Fluorescence in situ hybridization KW - D 04620:Microorganisms KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17121761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Molecular+Characterization+of+Subject-Specific+Oral+Microflora+during+Initial+Colonization+of+Enamel&rft.au=Diaz%2C+Patricia+I%3BChalmers%2C+Natalia+I%3BRickard%2C+Alexander+H%3BKong%2C+Colin%3BMilburn%2C+Craig+L%3BPalmer%2C+Robert+J%2C+Jr%3BKolenbrander%2C+Paul+E&rft.aulast=Diaz&rft.aufirst=Patricia&rft.date=2006-04-01&rft.volume=72&rft.issue=4&rft.spage=2837&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Teeth; Molecular modelling; Colonization; Community composition; Oral microflora; Biofilms; Dental plaque; rRNA 16S; Dental enamel; Fluorescence in situ hybridization; Prevotella; Neisseria; Veillonella; Streptococcus mitis; Actinomyces; Streptococcus oralis ER - TY - JOUR T1 - Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study AN - 17120544; 6750392 AB - This study compares the phylogenetic lineages of invasive serotype III group B streptococci (GBS) to those of colonizing strains in order to determine lineages associated with invasive disease. Isolates from 29 infants with early-onset disease (EOD) and from 196 colonized infants, collected in a prospective, multicenter study, were assigned a sequence type (ST) by multilocus sequence typing. Overall, 54.5% of the isolates were in the ST-19 complex, and 40.4% were in the ST-17 complex. Invasive strains were more likely to be in the ST-17 complex than were colonizing strains (59% versus 38%, P = 0.03). After we adjusted for potential confounders, the ST-17 complex was more likely to be associated with EOD than were other lineages (odds ratio = 2.51, 95% confidence interval = 1.02 to 6.20). These data support the hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS. JF - Journal of Clinical Microbiology AU - Lin, Feng-Ying C AU - Whiting, April AU - Adderson, Elisabeth AU - Takahashi, Shinji AU - Dunn, Diane Marie AU - Weiss, Robert AU - Azimi, Parvin H AU - Philips, Joseph BIII AU - Weisman, Leonard E AU - Regan, Joan AU - Clark, Penny AU - Rhoads, George G AU - Frasch, Carl E AU - Troendle, James AU - Moyer, Patricia AU - Bohnsack, John F AD - National Institute of Child Health and Human Development, National Institutes of Health. Center for Biologics Research and Review, Food and Drug Administration, Department of Health and Human Services, Bethesda, Maryland. Department of Pediatrics. Genome Center, University of Utah Health Sciences Center, Salt Lake City, Utah. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee. Division of Microbiology, Joshi-Eiyoh University, Saitama, Japan. Children's Hospital Medical Center of Northern California, Oakland, California. University of Alabama at Birmingham, Birmingham, Alabama. Baylor College of Medicine, Houston, Texas. Columbia University Health Sciences, New York, New York. University of Florida, Gainesville, Florida. University of Dentistry and Medicine of New Jersey, Piscataway, New Jersey Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1257 EP - 1261 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Serotypes KW - Guillain-Barre syndrome KW - Neonates KW - Infants KW - multilocus sequence typing KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17120544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Phylogenetic+Lineages+of+Invasive+and+Colonizing+Strains+of+Serotype+III+Group+B+Streptococci+from+Neonates%3A+a+Multicenter+Prospective+Study&rft.au=Lin%2C+Feng-Ying+C%3BWhiting%2C+April%3BAdderson%2C+Elisabeth%3BTakahashi%2C+Shinji%3BDunn%2C+Diane+Marie%3BWeiss%2C+Robert%3BAzimi%2C+Parvin+H%3BPhilips%2C+Joseph+BIII%3BWeisman%2C+Leonard+E%3BRegan%2C+Joan%3BClark%2C+Penny%3BRhoads%2C+George+G%3BFrasch%2C+Carl+E%3BTroendle%2C+James%3BMoyer%2C+Patricia%3BBohnsack%2C+John+F&rft.aulast=Lin&rft.aufirst=Feng-Ying&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phylogeny; Serotypes; Guillain-Barre syndrome; Neonates; multilocus sequence typing; Infants ER - TY - JOUR T1 - Performance of the Gen-Probe Transmission-Mediated Amplification Research Assay Compared to That of a Multitarget Real-Time PCR for Mycoplasma genitalium Detection AN - 17118153; 6750388 AB - Mycoplasma genitalium (MG) can cause nongonococcal urethritis and is potentially associated with urethritis, endometritis, and cervicitis. Several assays have been developed to detect MG. Molecular amplification assays for organism detection can be problematic due to the potential for false-positive and false-negative results. Confirmatory testing is often required in these situations, requiring additional time and resources. Use of multigene targets could integrate both detection and verification at lower cost. Utilizing two targets, the MgPa adhesion gene and the 16S rRNA gene, a multitarget real-time (MTRT) PCR for the detection of MG was developed. Samples from patients attending sexually transmitted disease clinics were collected in duplicate. Urine samples from males (n = 286) and self-collected vaginal swabs from females (n = 321) were analyzed by MTRT PCR for MG and the Gen-Probe transmission-mediated amplification (TMA) assay, which targets MG rRNA for detection (TMA-MG research use only). Utilizing the criteria of any two targets being positively amplified, the MTRT PCR had a sensitivity and specificity of 91.8% (101 positive samples/110 samples tested) and 99.5% (495/497), respectively, with a positive predictive value (PPV) of 98.1% (101/103) and a negative predictive value (NPV) of 98.2% (495/504). The Gen-Probe TMA-MG assay had a sensitivity, specificity, PPV, and NPV of 98.1% (108/110), 98.1% (488/497), 92.3% (108/117), and 99.5% (488/490), respectively. Comparison between the MTRT PCR and TMA-MG assay by kappa statistic analysis indicated that an overall kappa value was 0.941 (95% confidence interval, 0.907 and 0.976). Both assays demonstrated accuracy in the detection of MG from urine samples from male patients and self-collected vaginal swabs from female patients. JF - Journal of Clinical Microbiology AU - Hardick, Justin AU - Giles, Julie AU - Hardick, Andrew AU - Hsieh, Yu-Hsiang AU - Quinn, Thomas AU - Gaydos, Charlotte AD - Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland. Johns Hopkins University Department of Emergency Medicine, Baltimore, Maryland. National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 1236 EP - 1240 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - rRNA KW - Endometritis KW - Sexually-transmitted diseases KW - Urine KW - Mycoplasma genitalium KW - Vagina KW - Polymerase chain reaction KW - rRNA 16S KW - Urethritis KW - Cervicitis KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17118153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Performance+of+the+Gen-Probe+Transmission-Mediated+Amplification+Research+Assay+Compared+to+That+of+a+Multitarget+Real-Time+PCR+for+Mycoplasma+genitalium+Detection&rft.au=Hardick%2C+Justin%3BGiles%2C+Julie%3BHardick%2C+Andrew%3BHsieh%2C+Yu-Hsiang%3BQuinn%2C+Thomas%3BGaydos%2C+Charlotte&rft.aulast=Hardick&rft.aufirst=Justin&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=1236&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - rRNA; Endometritis; Sexually-transmitted diseases; Urine; Vagina; Polymerase chain reaction; rRNA 16S; Urethritis; Cervicitis; Mycoplasma genitalium ER - TY - JOUR T1 - Role of oxyR in the Oral Anaerobe Porphyromonas gingivalis AN - 17115136; 6747356 AB - Porphyromonas gingivalis is an anaerobic microorganism that inhabits the oral cavity, where oxidative stress represents a constant challenge. A putative transcriptional regulator associated with oxidative stress, an oxyR homologue, is known from the P. gingivalis W83 genome sequence. We used microarrays to characterize the response of P. gingivalis to H sub(2)O sub(2) and examine the role of oxyR in the regulation of this response. Most organisms in which oxyR has been investigated are facultative anaerobes or aerobes. In contrast to the OxyR-regulated response of these microorganisms to H sub(2)O sub(2), the main feature of the response in P. gingivalis was a concerted up-regulation of insertion sequence elements related to IS1 transposases. Common OxyR-regulated genes such as dps and ahpFC were not positively regulated in P. gingivalis in response to H sub(2)O sub(2). However, their expression was dependent on the presence of a functional OxyR, as revealed by microarray comparison of an oxyR mutant to the wild type. Phenotypic characterization of the oxyR mutant showed that OxyR plays a role in both the resistance to H sub(2)O sub(2) and the aerotolerance of P. gingivalis. Escherichia coli and other bacteria with more complex respiratory requirements use OxyR for regulating resistance to H sub(2)O sub(2) and use a separate regulator for aerotolerance. In P. gingivalis, the presence of a single protein combining the two functions might be related to the comparatively smaller genome size of this anaerobic microorganism. In conclusion, these results suggest that OxyR does not act as a sensor of H sub(2)O sub(2) in P. gingivalis but constitutively activates transcription of oxidative-stress-related genes under anaerobic growth. JF - Journal of Bacteriology AU - Diaz, Patricia I AU - Slakeski, Nada AU - Reynolds, Eric C AU - Morona, Renato AU - Rogers, Anthony H AU - Kolenbrander, Paul E AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland. School of Dental Science, The University of Melbourne, VIC, Australia. Department of Molecular and Life Sciences, The University of Adelaide, SA, Australia. Oral Microbiology Laboratory, Dental School, The University of Adelaide, SA, Australia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 2454 EP - 2462 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Porphyromonas gingivalis KW - Nucleotide sequence KW - Aerotolerance KW - Transcription KW - Anaerobic microorganisms KW - Insertion sequences KW - Oral cavity KW - transposase KW - Hydrogen peroxide KW - Oxidative stress KW - Escherichia coli KW - Microorganisms KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17115136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+oxyR+in+the+Oral+Anaerobe+Porphyromonas+gingivalis&rft.au=Diaz%2C+Patricia+I%3BSlakeski%2C+Nada%3BReynolds%2C+Eric+C%3BMorona%2C+Renato%3BRogers%2C+Anthony+H%3BKolenbrander%2C+Paul+E&rft.aulast=Diaz&rft.aufirst=Patricia&rft.date=2006-04-01&rft.volume=188&rft.issue=7&rft.spage=2454&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; transposase; Oxidative stress; Hydrogen peroxide; Nucleotide sequence; Aerotolerance; Microorganisms; Transcription; Anaerobic microorganisms; Insertion sequences; Oral cavity; Porphyromonas gingivalis; Escherichia coli ER - TY - JOUR T1 - A Database of Bacterial Lipoproteins (DOLOP) with Functional Assignments to Predicted Lipoproteins AN - 17111528; 6747393 AB - Lipid modification of the N-terminal Cys residue (N-acyl-S-diacylglyceryl-Cys) has been found to be an essential, ubiquitous, and unique bacterial posttranslational modification. Such a modification allows anchoring of even highly hydrophilic proteins to the membrane which carry out a variety of functions important for bacteria, including pathogenesis. Hence, being able to identify such proteins is of great value. To this end, we have created a comprehensive database of bacterial lipoproteins, called DOLOP, which contains information and links to molecular details for about 278 distinct lipoproteins and predicted lipoproteins from 234 completely sequenced bacterial genomes. The website also features a tool that applies a predictive algorithm to identify the presence or absence of the lipoprotein signal sequence in a user-given sequence. The experimentally verified lipoproteins have been classified into different functional classes and more importantly functional domain assignments using hidden Markov models from the SUPERFAMILY database that have been provided for the predicted lipoproteins. Other features include the following: primary sequence analysis, signal sequence analysis, and search facility and information exchange facility to allow researchers to exchange results on newly characterized lipoproteins. The website, along with additional information on the biosynthetic pathway, statistics on predicted lipoproteins, and related figures, is available at http://www.mrc-lmb.cam.ac.uk/genomes/dolop/. JF - Journal of Bacteriology AU - Babu, MMadan AU - Priya, MLeena AU - Selvan, ATamil AU - Madera, Martin AU - Gough, Julian AU - Aravind, L AU - Sankaran, K AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894. Centre for Biotechnology, Anna University, Chennai 600025, India. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. RIKEN Genomic Sciences Centre, W121 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 2761 EP - 2773 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 8 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteria KW - Databases KW - Statistics KW - hidden Markov models KW - Lipids KW - Lipoproteins KW - Algorithms KW - Statistical analysis KW - Amino acid sequence KW - A 01300:Methods KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17111528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=A+Database+of+Bacterial+Lipoproteins+%28DOLOP%29+with+Functional+Assignments+to+Predicted+Lipoproteins&rft.au=Babu%2C+MMadan%3BPriya%2C+MLeena%3BSelvan%2C+ATamil%3BMadera%2C+Martin%3BGough%2C+Julian%3BAravind%2C+L%3BSankaran%2C+K&rft.aulast=Babu&rft.aufirst=MMadan&rft.date=2006-04-01&rft.volume=188&rft.issue=8&rft.spage=2761&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Statistics; hidden Markov models; Lipids; Lipoproteins; Statistical analysis; Algorithms; Amino acid sequence; Bacteria ER - TY - JOUR T1 - Risk factors for human herpesvirus 8 seropositivity in the AIDS Cancer Cohort Study AN - 17110107; 6742078 AB - Background: Cigarette smoking has been associated with a decreased risk for AIDS-related and classical KS, but whether it is associated with decreased risk of human herpesvirus 8 (HHV-8) infection is unknown. Study design: We evaluated factors associated with HHV-8 seropositivity in 2795 participants (132 with KS) in the National Cancer Institute AIDS Cancer Cohort, including 1621 men who have sex with men (MSM), 660 heterosexual men and 514 women. Odds ratios (OR) and 95% confidence intervals were estimated using logistic regression models. Results: Among non-KS subjects, HHV-8 seropositivity was 6%, 13% and 29% among women, heterosexual men and MSM, respectively. HHV-8 seropositivity was decreased in heavier (>=1/2 pack/day) compared to lighter smokers among women (5% versus 8%; adjusted OR (aOR) 0.4; 95% CI 0.2-0.8) and MSM (27% versus 32%; aOR 0.7; 95% CI 0.6-1.0), but not among heterosexual men (12% versus 16%; aOR 0.7; 95% CI 0.4-1.2). HHV-8 seroprevalence was increased in heavier (>=1 drink/day) compared to lighter consumers of alcohol among women (16% versus 4%; adjusted OR 5.2; 95% CI 2.3-12), but not among MSM (33% versus 28%; aOR 1.2; 95% CI 0.9-1.6) or heterosexual men (13% versus 13%; aOR 1.1; 95% CI 0.6-2.0). In analyses adjusted for smoking and drinking, HHV-8 seropositivity was positively associated with chlamydia infection (OR=4.3; 95% CI 1.2-13) and with marital status among women p sub(h) sub(e) sub(t) sub(e) sub(r) sub(o) sub(g) sub(e) sub(n) sub(e) sub(i) sub(t) sub(y)=0.03, and with hepatitis (OR=1.6; 95% CI 1.2-2.1), gonorrhea (OR=1.5; 95% CI 1.1-1.9), genital warts (OR=1.5; 95% CI 1.1-2.0) and nitrate inhalant use (OR=1.7; 95% CI 1.3-2.3) among MSM. Conclusions: Inverse association of HHV-8 seropositivity with cigarette smoking may indicate protective effect of tobacco smoke on HHV-8 infection, whereas positive associations with alcohol may reflect either behavioral factors or biological effects modulating susceptibility. Smoking and drinking may influence KS risk, at least in part, by altering the natural history of HHV-8 infection. JF - Journal of Clinical Virology AU - Mbulaiteye, S M AU - Atkinson, JO AU - Whitby, D AU - Wohl, DA AU - Gallant, JE AU - Royal, S AU - Goedert, J J AU - Rabkin, C S AD - National Cancer Institute, Department of Health and Human Services, 6120 Executive Blvd, Executive Plaza South Rm 8006. Mail Stop Center 7248, Rockville, MD 20852, United States, mbulaits@mail.nih.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 442 EP - 449 PB - Elsevier B.V. VL - 35 IS - 4 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Risk assessment KW - Drinking KW - Nitrate KW - Acquired immune deficiency syndrome KW - Beverages KW - Human herpesvirus 8 KW - Infection KW - Cancer KW - Models KW - Hepatitis KW - Smoke KW - Inhalants KW - Warts KW - Risk factors KW - Cigarette smoking KW - Regression analysis KW - alcohols KW - Tobacco KW - Drinking behavior KW - Gonorrhea KW - Consumers KW - Chlamydia KW - Sex KW - V 22006:AIDS: Other aspects KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17110107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Risk+factors+for+human+herpesvirus+8+seropositivity+in+the+AIDS+Cancer+Cohort+Study&rft.au=Mbulaiteye%2C+S+M%3BAtkinson%2C+JO%3BWhitby%2C+D%3BWohl%2C+DA%3BGallant%2C+JE%3BRoyal%2C+S%3BGoedert%2C+J+J%3BRabkin%2C+C+S&rft.aulast=Mbulaiteye&rft.aufirst=S&rft.date=2006-04-01&rft.volume=35&rft.issue=4&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2005.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Drinking; Risk assessment; Nitrate; Acquired immune deficiency syndrome; Beverages; Infection; Cancer; Models; Smoke; Hepatitis; Inhalants; Warts; Risk factors; Cigarette smoking; Tobacco; alcohols; Regression analysis; Drinking behavior; Consumers; Gonorrhea; Sex; Human herpesvirus 8; Chlamydia DO - http://dx.doi.org/10.1016/j.jcv.2005.10.010 ER - TY - JOUR T1 - Development of an improved method of detection of infectious parvovirus B19 AN - 17107561; 6742071 AB - Background: Parvovirus B19, the only known pathogenic human parvovirus is the aetiologic agent of erythema infectiosum, transient aplastic crisis, pure red cell aplasia, and hydrops fetalis. Transmission is either by respiratory secretions or, as it can be present at high titre in plasma, by blood and blood products. B19 is only cultured with difficulty in vitro, and there is no readily available assay for detecting B19 infectivity or neutralizing antibodies. Objectives: In this study, we evaluated different methods to detect viral infection for the purpose of developing automated methods for large-scale testing of viral infectivity, development of neutralizing antibody and viral inactivation assays. Study design: Different cell lines were evaluated for their ability to support B19 infection and assays tested for sensitivity and ease of performing. A high-throughput assay was validated by determining infectious virus in blood pools and for determining neutralizing antibody in sera. Results: B19 protein production was detected by immunofluorescence (IF) staining and increased viral DNA production by dot blot hybridization and quantitative PCR. The detection of RNA transcripts by RT-PCR assay and quantitative RT-PCR (qRT-PCR) was used as an indirect marker for infection. Of the cell lines tested, the subclone UT7/Epo-S1 showed the greatest sensitivity to B19 infection, with detection of viral transcripts by qRT-PCR the preferred assay. The assays were validated by experiments to determine the infectious titre of sera from acutely infected humans, to evaluate the presence of infectious virus in human donor plasma pools and to measure neutralizing antibodies. JF - Journal of Clinical Virology AU - Wong, S AU - Brown, KE AD - National Heart, Lung and Blood Institute, Bethesda, MD, USA, Kevin.Brown@HPA.org.uk Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 407 EP - 413 PB - Elsevier B.V. VL - 35 IS - 4 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Blood products KW - Secretions KW - Automation KW - Immunofluorescence KW - Infection KW - Blood KW - Aplasia KW - Antibodies KW - Infectivity KW - Erythema infectiosum KW - Parvovirus B19 KW - RNA KW - Polymerase chain reaction KW - A 01114:Viruses KW - V 22121:Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17107561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Development+of+an+improved+method+of+detection+of+infectious+parvovirus+B19&rft.au=Wong%2C+S%3BBrown%2C+KE&rft.aulast=Wong&rft.aufirst=S&rft.date=2006-04-01&rft.volume=35&rft.issue=4&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2005.12.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Aplasia; Blood products; Blood; Erythema infectiosum; Infectivity; Antibodies; RNA; Secretions; Automation; Polymerase chain reaction; Immunofluorescence; Infection; Parvovirus B19 DO - http://dx.doi.org/10.1016/j.jcv.2005.12.008 ER - TY - JOUR T1 - Development and evaluation of a rapid IgM capture ELISA (JEV-Chex) for the diagnosis of Japanese encephalitis AN - 17106412; 6742076 AB - Background: The IgM capture ELISA has been the most widely used diagnostic method for Japanese encephalitis. However, the lack of availability of validated commercial kits as well as the short shelf life of the kit reagents has limited the use of this technique to very few centres in Asia. Objectives: Development and evaluation of a rapid IgM capture ELISA (JEV Chex) in comparison to the conventional IgM capture ELISA. Produce key reagents such as cell culture derived JEV antigen and biotinylated monoclonal antibody which are stable at room temperature. Study design: The conventional IgM capture ELISA was modified to reduce the total assay time and two key reagents used in the assay JEV antigen and biotinylated anti-JEV monoclonal antibodies were rendered stable at room temperature using a special procedure. A multi-centric evaluation of this rapid ELISA was carried out using well characterized stored CSF and serum samples. Long term stability of the key reagents was also assessed over a period of 6 months. Results: The rapid IgM capture ELISA developed by us showed complete concordance with the results obtained using the conventional ELISA at all the three centres where it was evaluated. In addition, the stability studies carried out with the inactivated cell culture antigen and the biotinylated monoclonal antibodies stored at room temperature for a period of 180 days revealed that both these reagents yielded consistent optical density values in the ELISA. Conclusions: The rapid ELISA format of the IgM capture ELISA (JEV-Chex) developed by us as well as the stability of reagents achieved by us in this study is what renders this rapid IgM capture ELISA very robust and user friendly since reagents can be stored at 4 super(o)C by peripheral labs. JF - Journal of Clinical Virology AU - Ravi, V AU - Desai, A AU - Balaji, M AU - Apte, M P AU - Lakshman, L AU - Subbakrishna, D K AU - Sridharan, G AU - Dhole, T N AU - Ravikumar, B V AD - National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India, vravi@nimhans.kar.nic.in Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 429 EP - 434 PB - Elsevier B.V. VL - 35 IS - 4 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Temperature effects KW - Enzyme-linked immunosorbent assay KW - Japanese encephalitis KW - Monoclonal antibodies KW - Colony-stimulating factor KW - Optical density KW - Cell culture KW - Shelf life KW - Immunoglobulin M KW - A 01114:Viruses KW - V 22091:Immunological techniques & reagents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Development+and+evaluation+of+a+rapid+IgM+capture+ELISA+%28JEV-Chex%29+for+the+diagnosis+of+Japanese+encephalitis&rft.au=Ravi%2C+V%3BDesai%2C+A%3BBalaji%2C+M%3BApte%2C+M+P%3BLakshman%2C+L%3BSubbakrishna%2C+D+K%3BSridharan%2C+G%3BDhole%2C+T+N%3BRavikumar%2C+B+V&rft.aulast=Ravi&rft.aufirst=V&rft.date=2006-04-01&rft.volume=35&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2005.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Japanese encephalitis; Enzyme-linked immunosorbent assay; Colony-stimulating factor; Monoclonal antibodies; Optical density; Cell culture; Shelf life; Immunoglobulin M DO - http://dx.doi.org/10.1016/j.jcv.2005.11.004 ER -