TY - CPAPER T1 - Strategic Regulation of Excision Repair Through Structural and Chemical Biology T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40116683; 4084285 DE: JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Wilson, Samuel H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=Strategic+Regulation+of+Excision+Repair+Through+Structural+and+Chemical+Biology&rft.au=Wilson%2C+Samuel+H&rft.aulast=Wilson&rft.aufirst=Samuel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - All in the Family: the Role of the Polypeptide:GalNac Transferases in Development and Disease in the Craniofacial Complex T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40116600; 4084265 JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Tabak, Larry Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Transferases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=All+in+the+Family%3A+the+Role+of+the+Polypeptide%3AGalNac+Transferases+in+Development+and+Disease+in+the+Craniofacial+Complex&rft.au=Tabak%2C+Larry&rft.aulast=Tabak&rft.aufirst=Larry&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Studies of Post-Transcriptional Gene Regulation T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40075413; 4084307 JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Hall, Traci M.T. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene regulation KW - Post-transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40075413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=Structural+Studies+of+Post-Transcriptional+Gene+Regulation&rft.au=Hall%2C+Traci+M.T.&rft.aulast=Hall&rft.aufirst=Traci&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Fibroblast Growth Factor Receptor-1 (FGFR1) by Thyroid Hormone (T3): Identification of a Thyroid Hormone Response Element (TRE) in the Murine FGFR1 Promoter T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 40030152; 4233946 JF - 8th European Congress of Endocrinology (ECE 2006) AU - O'Shea, P J AU - Williams, G R AU - Cheng, S Y Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hormones KW - Thyroid hormones KW - Fibroblast growth factor receptor 1 KW - Regulatory sequences KW - Promoters KW - Triiodothyronine KW - Fibroblast growth factor KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40030152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Regulation+of+Fibroblast+Growth+Factor+Receptor-1+%28FGFR1%29+by+Thyroid+Hormone+%28T3%29%3A+Identification+of+a+Thyroid+Hormone+Response+Element+%28TRE%29+in+the+Murine+FGFR1+Promoter&rft.au=O%27Shea%2C+P+J%3BWilliams%2C+G+R%3BCheng%2C+S+Y&rft.aulast=O%27Shea&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Chemoimmunotherapy in a Pancreatic Cancer Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40019292; 4185929 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hance, Kenneth W AU - Rogers, Connie J AU - Zaharoff, David A AU - Schlom, Jeffrey AU - Greiner, John W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pancreatic cancer KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Combination+Chemoimmunotherapy+in+a+Pancreatic+Cancer+Model&rft.au=Hance%2C+Kenneth+W%3BRogers%2C+Connie+J%3BZaharoff%2C+David+A%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Hance&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Papilloma Virus: What it is and What it Does T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40014954; 4181503 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lowy, Douglas Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Cancer KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40014954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Papilloma+Virus%3A+What+it+is+and+What+it+Does&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nm23-H1 Mediates Metastasis Suppression through the Receptors Edg2 and C-Met in MDA-MB-435 Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40013075; 4184255 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Horak, Christine E AU - Lee, Jong Heun AU - Elkahoun, Abdel AU - Palmieri, Diane AU - Halverson, Douglas O AU - Meltzer, Paul AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nm23-H1+Mediates+Metastasis+Suppression+through+the+Receptors+Edg2+and+C-Met+in+MDA-MB-435+Cells&rft.au=Horak%2C+Christine+E%3BLee%2C+Jong+Heun%3BElkahoun%2C+Abdel%3BPalmieri%2C+Diane%3BHalverson%2C+Douglas+O%3BMeltzer%2C+Paul%3BSteeg%2C+Patricia+S&rft.aulast=Horak&rft.aufirst=Christine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Fluid Concentrations of Platinum Analogs in Brain, Blood and Muscle Using Microdialysis in a Nonhuman Primate Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009878; 4186203 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jacobs, Shana S AU - McCully, Cynthia L AU - Bacher, John AU - Balis, Frank AU - Fox, Elizabeth Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Blood KW - Platinum KW - Muscles KW - Brain KW - Microdialysis KW - Analogs KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Extracellular+Fluid+Concentrations+of+Platinum+Analogs+in+Brain%2C+Blood+and+Muscle+Using+Microdialysis+in+a+Nonhuman+Primate+Model&rft.au=Jacobs%2C+Shana+S%3BMcCully%2C+Cynthia+L%3BBacher%2C+John%3BBalis%2C+Frank%3BFox%2C+Elizabeth&rft.aulast=Jacobs&rft.aufirst=Shana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association between the Anti-Inflammatory Protein CC10 and Smoking Status Among Participants in a Chemoprevention Trial T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009877; 4186207 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chen, Jiping AU - Lam, Stephen AU - Pilon, Aprile AU - Szabo, Eva Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Smoking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Association+between+the+Anti-Inflammatory+Protein+CC10+and+Smoking+Status+Among+Participants+in+a+Chemoprevention+Trial&rft.au=Chen%2C+Jiping%3BLam%2C+Stephen%3BPilon%2C+Aprile%3BSzabo%2C+Eva&rft.aulast=Chen&rft.aufirst=Jiping&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Functional Group of Thalidomide Analogues Selectively Kill Leukemic Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009505; 4184111 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ge, Yun AU - Montano, Idalia AU - Freebern, Wendy J AU - Haggerty, Cynthia M AU - Cui, Wenwu AU - Ponciano-Jackson, Damaris AU - Chandramouli, G V R AU - Lepper, Erin AU - Figg, William D AU - Jackson, Sharon H AU - Gardner, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Leukemia KW - Thalidomide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Novel+Functional+Group+of+Thalidomide+Analogues+Selectively+Kill+Leukemic+Cells&rft.au=Ge%2C+Yun%3BMontano%2C+Idalia%3BFreebern%2C+Wendy+J%3BHaggerty%2C+Cynthia+M%3BCui%2C+Wenwu%3BPonciano-Jackson%2C+Damaris%3BChandramouli%2C+G+V+R%3BLepper%2C+Erin%3BFigg%2C+William+D%3BJackson%2C+Sharon+H%3BGardner%2C+Kevin&rft.aulast=Ge&rft.aufirst=Yun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Cancer Cell Lines Resistant to Either Tamoxifen or Herceptin Exhibit Sensitivity to the Anti-IGF Receptor Antibody A12 In Vitro T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009220; 4184478 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Best, Carolyn J.M. AU - Ludwig, Dale L AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Antibodies KW - Tumor cell lines KW - Tamoxifen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Breast+Cancer+Cell+Lines+Resistant+to+Either+Tamoxifen+or+Herceptin+Exhibit+Sensitivity+to+the+Anti-IGF+Receptor+Antibody+A12+In+Vitro&rft.au=Best%2C+Carolyn+J.M.%3BLudwig%2C+Dale+L%3BSteeg%2C+Patricia+S&rft.aulast=Best&rft.aufirst=Carolyn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Cell Spreading and Migration by Candidate Tumor Suppressor ING4 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008861; 4186945 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Shen, Jiang C AU - Kumamoto, Kensuke AU - Unoki, Motoko AU - Varticovski, Lyuba AU - Pedeux, Remy AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cell migration KW - Tumor suppressor genes KW - Cell spreading KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Regulation+of+Cell+Spreading+and+Migration+by+Candidate+Tumor+Suppressor+ING4&rft.au=Shen%2C+Jiang+C%3BKumamoto%2C+Kensuke%3BUnoki%2C+Motoko%3BVarticovski%2C+Lyuba%3BPedeux%2C+Remy%3BHarris%2C+Curtis+C&rft.aulast=Shen&rft.aufirst=Jiang&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Profiling Distinguishes Astrocytomas of Different Grades and Identifies Differential Tumor Markers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008550; 4186448 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Jie AU - Weil, Robert AU - Okamoto, Hiroaki AU - Vortmeyer, Alexander AU - Lubensky, Irina AU - Park, Deric AU - Furuta, Makoto AU - Lee, Youn-Soo AU - Zeng, Weifen AU - Oldfield, Edward H AU - Zhuang, Zhengping Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor markers KW - Proteomics KW - Astrocytoma KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Profiling+Distinguishes+Astrocytomas+of+Different+Grades+and+Identifies+Differential+Tumor+Markers&rft.au=Li%2C+Jie%3BWeil%2C+Robert%3BOkamoto%2C+Hiroaki%3BVortmeyer%2C+Alexander%3BLubensky%2C+Irina%3BPark%2C+Deric%3BFuruta%2C+Makoto%3BLee%2C+Youn-Soo%3BZeng%2C+Weifen%3BOldfield%2C+Edward+H%3BZhuang%2C+Zhengping&rft.aulast=Li&rft.aufirst=Jie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Barriers to Eye Care: Results of Qualitative Research T2 - 3rd Annual International Health Conference of the Unite For Sight AN - 40004322; 4194600 JF - 3rd Annual International Health Conference of the Unite For Sight AU - Alexander, Robert Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Eye KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Barriers+to+Eye+Care%3A+Results+of+Qualitative+Research&rft.au=Alexander%2C+Robert&rft.aulast=Alexander&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.uniteforsight.org/2006_annual_conference.php#cliffocallahan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SCIMS: A New Algorithm for Associating Anticancer Drug Mechanisms with Gene Ontology Categories T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002915; 4184991 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Eichler, Gabriel S AU - Reimers, Mark AU - Weinstein, John N Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Algorithms KW - Mathematical models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=SCIMS%3A+A+New+Algorithm+for+Associating+Anticancer+Drug+Mechanisms+with+Gene+Ontology+Categories&rft.au=Eichler%2C+Gabriel+S%3BReimers%2C+Mark%3BWeinstein%2C+John+N&rft.aulast=Eichler&rft.aufirst=Gabriel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Aryl Hydrocarbon Receptor Repressor, a Candidate Tumor Suppressor Gene T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000778; 4182617 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zudaire, Enrique AU - Cuesta, Natalia AU - Murty, Vundavalli AU - Martinez, Alfredo AU - Narayan, Gopeshwar AU - Birrer, Mike AU - Kirsch, IlanR AU - Cuttitta, Frank Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hydrocarbons KW - Repressors KW - Tumor suppressor genes KW - Aryl hydrocarbon receptors KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Aryl+Hydrocarbon+Receptor+Repressor%2C+a+Candidate+Tumor+Suppressor+Gene&rft.au=Zudaire%2C+Enrique%3BCuesta%2C+Natalia%3BMurty%2C+Vundavalli%3BMartinez%2C+Alfredo%3BNarayan%2C+Gopeshwar%3BBirrer%2C+Mike%3BKirsch%2C+IlanR%3BCuttitta%2C+Frank&rft.aulast=Zudaire&rft.aufirst=Enrique&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Transmembrane Chemokine CXCL16 is Highly Expressed in Inflammation-Associated Cancers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000623; 4182209 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Darash-Yahana, Merav AU - Gillespie, John W AU - Hewitt, Stephen M AU - Chen, Yun-Yun K AU - Maeda, Shin AU - Stein, Ilan AU - Peled, Amnon AU - Pikarsky, Eli AU - Karin, Michael AU - Farber, Joshua M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - CXCL16 protein KW - Chemokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Transmembrane+Chemokine+CXCL16+is+Highly+Expressed+in+Inflammation-Associated+Cancers&rft.au=Darash-Yahana%2C+Merav%3BGillespie%2C+John+W%3BHewitt%2C+Stephen+M%3BChen%2C+Yun-Yun+K%3BMaeda%2C+Shin%3BStein%2C+Ilan%3BPeled%2C+Amnon%3BPikarsky%2C+Eli%3BKarin%2C+Michael%3BFarber%2C+Joshua+M&rft.aulast=Darash-Yahana&rft.aufirst=Merav&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling Enhances TRAIL-Induced Apoptosis in Breast Cancer Cells by a PI3-Kinase Dependant but Akt Independent Mechanism T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39998655; 4182344 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rahman, Monzur AU - Bao, Jing AU - Nau, Marion M AU - Nguyen, Dao M AU - Lipkowitz, Stan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Epidermal growth factor receptors KW - Signal transduction KW - 1-Phosphatidylinositol 3-kinase KW - Apoptosis KW - AKT protein KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Inhibition+of+Epidermal+Growth+Factor+Receptor+%28EGFR%29+Signaling+Enhances+TRAIL-Induced+Apoptosis+in+Breast+Cancer+Cells+by+a+PI3-Kinase+Dependant+but+Akt+Independent+Mechanism&rft.au=Rahman%2C+Monzur%3BBao%2C+Jing%3BNau%2C+Marion+M%3BNguyen%2C+Dao+M%3BLipkowitz%2C+Stan&rft.aulast=Rahman&rft.aufirst=Monzur&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - XAF1 mRNA Expression Does not Predict Pathological Response Nor Prognosis in Advanced Bladder Cancer Patients Treated with Neoadjuvant Chemotherapy T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39987608; 4183894 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pinho, Marcos B AU - Sellos, Joao AU - Costas, Fernanda AU - Herchenhorn, Daniel AU - Peixoto, Fabio Afonso AU - Diengsm, Rodrigo AU - Small, Isabelle A AU - Xavier, Marisa AU - Cardoso, Hedilene AU - Guimaraes, Denise P AU - Ferreira, Carlos G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Chemotherapy KW - Cancer KW - Gene expression KW - Urinary bladder KW - Prognosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=XAF1+mRNA+Expression+Does+not+Predict+Pathological+Response+Nor+Prognosis+in+Advanced+Bladder+Cancer+Patients+Treated+with+Neoadjuvant+Chemotherapy&rft.au=Pinho%2C+Marcos+B%3BSellos%2C+Joao%3BCostas%2C+Fernanda%3BHerchenhorn%2C+Daniel%3BPeixoto%2C+Fabio+Afonso%3BDiengsm%2C+Rodrigo%3BSmall%2C+Isabelle+A%3BXavier%2C+Marisa%3BCardoso%2C+Hedilene%3BGuimaraes%2C+Denise+P%3BFerreira%2C+Carlos+G&rft.aulast=Pinho&rft.aufirst=Marcos&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges Associated with the Diagnosis, Differential Diagnosis and Treatment of 4 Cases of ACTH-Dependent Cushing's Syndrome due to Intermittent Hypercortisolism T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 39987301; 4233497 JF - 8th European Congress of Endocrinology (ECE 2006) AU - Lindsay, J R AU - Nieman, L K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cushing's syndrome KW - Differential diagnosis KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Challenges+Associated+with+the+Diagnosis%2C+Differential+Diagnosis+and+Treatment+of+4+Cases+of+ACTH-Dependent+Cushing%27s+Syndrome+due+to+Intermittent+Hypercortisolism&rft.au=Lindsay%2C+J+R%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression Associated with Achaete-Scute Homologue-1 (hASH1) in a Mouse Neuroendocrine Lung Cancer Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39985626; 4187082 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, Heungnam AU - Wang, Xiaoyang AU - Dakir, El Habib AU - Demayo, Franco AU - Linnoila, Ilona Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Gene expression KW - Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Differential+Gene+Expression+Associated+with+Achaete-Scute+Homologue-1+%28hASH1%29+in+a+Mouse+Neuroendocrine+Lung+Cancer+Model&rft.au=Kim%2C+Heungnam%3BWang%2C+Xiaoyang%3BDakir%2C+El+Habib%3BDemayo%2C+Franco%3BLinnoila%2C+Ilona&rft.aulast=Kim&rft.aufirst=Heungnam&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma and Cerobrospinal Fluid (CSF) Pharmacokinetics of the Histone Deacetylase (HDAC) Inhibitor, PXD101, in Non-Human Primates T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39982982; 4187345 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Warren, Katherine E AU - McCully, Cindy M AU - Dvinge, Henrik AU - Sehested, Maxwell AU - Tjornelund, Jette AU - Lichenstein, Henri S AU - Balis, Frank M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pharmacokinetics KW - Histone deacetylase KW - Colony-stimulating factor KW - Histones KW - Inhibitors KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39982982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=An+O-Glycosyltransferase+is+Required+during+Multiple+Stages+of+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Operative Serum Cortisol for Prediction of Long-Term Remission from Cushing's Syndrome T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 39977642; 4233538 JF - 8th European Congress of Endocrinology (ECE 2006) AU - Lindsay, J R AU - Oldfield, E H AU - Nieman, L K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cushing's syndrome KW - Remission KW - Hydrocortisone KW - Serum KW - Symptoms KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Post-Operative+Serum+Cortisol+for+Prediction+of+Long-Term+Remission+from+Cushing%27s+Syndrome&rft.au=Lindsay%2C+J+R%3BOldfield%2C+E+H%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Therapy of a Murine Model of Anaplastic Large Cell Lymphoma with an Anti-CD30 Monoclonal Antibody, HeFi-1, Armed with the Alpha Emitter, @@u211@At T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39977318; 4186205 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zhang, Meili AU - Yao, Zhengsheng AU - Patel, Hiral AU - Zhang, Zhuo AU - Garmestani, Kayhan AU - Talanov, Vladimir S AU - Plascjak, Paul S AU - Goldman, Carolyn K AU - Brechbiel, Martin W AU - Waldmann, Thomas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Monoclonal antibodies KW - Animal models KW - Anaplastic large-cell lymphoma KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Drosophila+Homologue+of+the+Human+Tumor+Suppressor+Gene+BHD+Regulates+Male+Germline+Stem+Cell+Maintenance+and+Functions+Downstream+of+Dpp&rft.au=Singh%2C+Shree+R%3BZen%2C+Wei%3BZheng%2C+Zhiyu%3BWang%2C+Hong%3BOh%2C+Su-Wan%3BLiu%2C+Wei%3BZbar%2C+Berton%3BSchmidt%2C+Laura+S%3BHou%2C+Steven+X&rft.aulast=Singh&rft.aufirst=Shree&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Somatic Sequence Alterations in Genes Selected by Expression Profile Analysis of Breast Carcinomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39977148; 4186165 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chanock, Stephen AU - Burdett, Laurie AU - Yeager, Meredith AU - Llaca, Victor AU - Langerod, Anita AU - Presswalla, Shafaq AU - Kaaresen, Rolf AU - Strausberg, Robert L AU - Gerhard, Daniela S AU - Kristensen, Vessela AU - Perou, Charles M AU - Borresen-Dale, Anne-Lise Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Breast carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Somatic+Sequence+Alterations+in+Genes+Selected+by+Expression+Profile+Analysis+of+Breast+Carcinomas&rft.au=Chanock%2C+Stephen%3BBurdett%2C+Laurie%3BYeager%2C+Meredith%3BLlaca%2C+Victor%3BLangerod%2C+Anita%3BPresswalla%2C+Shafaq%3BKaaresen%2C+Rolf%3BStrausberg%2C+Robert+L%3BGerhard%2C+Daniela+S%3BKristensen%2C+Vessela%3BPerou%2C+Charles+M%3BBorresen-Dale%2C+Anne-Lise&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MRI Assessment of Nitroxide-Mediated Selective Normal Tissue Radioprotection T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39976055; 4184303 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Cotrim, Ana P AU - Hyodo, Fuminori AU - Sowers, Anastasia L AU - Matsumoto, Ken-Ichiro AU - Baum, Bruce J AU - Krishna, Murali C AU - Mitchell, James B Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Magnetic resonance imaging KW - Radioprotection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39976055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=MRI+Assessment+of+Nitroxide-Mediated+Selective+Normal+Tissue+Radioprotection&rft.au=Cotrim%2C+Ana+P%3BHyodo%2C+Fuminori%3BSowers%2C+Anastasia+L%3BMatsumoto%2C+Ken-Ichiro%3BBaum%2C+Bruce+J%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Second Cancer Incidence and Cause-Specific Mortality Following Hairy Cell Leukemia: A Population-Based Study of 3,104 Patients T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39975164; 4183768 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hisada, Michie AU - Jaffe, Elaine S AU - Travis, Lois B Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Leukemia KW - Mortality KW - Cancer KW - Hairy cell leukemia KW - Population studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39975164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Second+Cancer+Incidence+and+Cause-Specific+Mortality+Following+Hairy+Cell+Leukemia%3A+A+Population-Based+Study+of+3%2C104+Patients&rft.au=Hisada%2C+Michie%3BJaffe%2C+Elaine+S%3BTravis%2C+Lois+B&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of STAT3 Signaling in Wnt5a-Mediated Regulation of MART1 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39974844; 4186889 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dissanayake, Samudra K AU - Rosenthal, Devin T AU - Hewitt, Kyle J AU - Yang, Sherry AU - Wade, Michael AU - Taub, Dennis D AU - Nickoloff, Brian J AU - Trent, Jeffrey M AU - Bittner, Michael AU - Riker, Adam I AU - Weeraratna, Ashani T Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction KW - Stat3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39974844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Involvement+of+STAT3+Signaling+in+Wnt5a-Mediated+Regulation+of+MART1&rft.au=Dissanayake%2C+Samudra+K%3BRosenthal%2C+Devin+T%3BHewitt%2C+Kyle+J%3BYang%2C+Sherry%3BWade%2C+Michael%3BTaub%2C+Dennis+D%3BNickoloff%2C+Brian+J%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael%3BRiker%2C+Adam+I%3BWeeraratna%2C+Ashani+T&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Hsp90 compromises the DNA Damage Response to Radiation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39974117; 4184569 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dote, Hideaki AU - Burgan, William E AU - Camphausen, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Radiation KW - DNA damage KW - Hsp90 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39974117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Inhibition+of+Hsp90+compromises+the+DNA+Damage+Response+to+Radiation&rft.au=Dote%2C+Hideaki%3BBurgan%2C+William+E%3BCamphausen%2C+Kevin&rft.aulast=Dote&rft.aufirst=Hideaki&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromogenic in Situ Hybridization (CISH) for X- And Y-Chromosomes in Sex Determination of Anatomic Pathology Specimens T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973504; 4183827 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Silva, Aloisio S AU - Palau, Mauricio AU - Merino, Maria J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pathology KW - Sex determination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chromogenic+in+Situ+Hybridization+%28CISH%29+for+X-+And+Y-Chromosomes+in+Sex+Determination+of+Anatomic+Pathology+Specimens&rft.au=Silva%2C+Aloisio+S%3BPalau%2C+Mauricio%3BMerino%2C+Maria+J&rft.aulast=Silva&rft.aufirst=Aloisio&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Sequence Analysis of Known Cancer Genes in the NCI-60 Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973061; 4186166 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ikediobi, Ogechi AU - Edkins, Sarah AU - Stevens, Claire AU - O'Meara, Sarah AU - Bignell, Graham AU - Teague, Jon AU - Butler, Adam AU - Buck, Gemma AU - Gray, Kristian AU - Halliday, Kelly AU - Kosmidou, Vivienne AU - Lugg, Richard AU - Menzies, Andrew AU - Perry, Janet AU - Petty, Robert AU - Raine, Keiran AU - Reinhold, William AU - Shepherd, Rebecca AU - Small, Alex AU - Widaa, Sara AU - Varian, Jennifer AU - Weinstein, John AU - Stratton, Micheal AU - Futreal, Andrew AU - Wooster, Richard Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Preliminary+Evaluation+of+Haptic+Feedback+Tools+for+CT-Guided+Robotic+Interventions.&rft.au=Viswanathan%2C+A%3BYanof%2C+J+H%3BBauer%2C+C%3BXu%2C+S.%3BKruecker%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Evidence of Synergism between DNA Damaging Agents and the HSP90 Inhibitor, 17-DMAG, in Tumors with Mutant P53 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39972743; 4184088 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Robles, Ana I AU - Wright, Mollie H AU - Ghandi, Bheru AU - Feis, Steven AU - Harris, Curtis C AU - Varticovski, Lyuba Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mutants KW - Synergism KW - P53 protein KW - DNA damage KW - Hsp90 protein KW - Tumors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39972743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Preclinical+Evidence+of+Synergism+between+DNA+Damaging+Agents+and+the+HSP90+Inhibitor%2C+17-DMAG%2C+in+Tumors+with+Mutant+P53&rft.au=Robles%2C+Ana+I%3BWright%2C+Mollie+H%3BGhandi%2C+Bheru%3BFeis%2C+Steven%3BHarris%2C+Curtis+C%3BVarticovski%2C+Lyuba&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Gene Expression Profiling of Mucinous Ovarian Tumors and Cystadenomas Identifies Genes of Clinicopathologic Importance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39971067; 4183876 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wamunyokoli, Fred W A AU - Bonome, Tomas AU - Lee, Ji-Young AU - Feltmate, Colleen M AU - Welch, William R AU - Radonovich, Mike AU - Pise-Masison, Cindy AU - Brady, John AU - Hao, Ke AU - Berkowitz, Ross S AU - Mok, Samuel AU - Birrer, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Global+Gene+Expression+Profiling+of+Mucinous+Ovarian+Tumors+and+Cystadenomas+Identifies+Genes+of+Clinicopathologic+Importance&rft.au=Wamunyokoli%2C+Fred+W+A%3BBonome%2C+Tomas%3BLee%2C+Ji-Young%3BFeltmate%2C+Colleen+M%3BWelch%2C+William+R%3BRadonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBrady%2C+John%3BHao%2C+Ke%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel%3BBirrer%2C+Michael+J&rft.aulast=Wamunyokoli&rft.aufirst=Fred+W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imprinted Adaptor Protein Grb10 Interacts Genetically with Nf1/p53 in Development and Tumorigenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969837; 4187461 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reilly, Karlyne M AU - Tuskan, Robert AU - Kumar, Krishan AU - Stewart, Colin AU - Hagan, John AU - Fox, Kristi Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumorigenesis KW - P53 protein KW - Adaptor proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Imprinted+Adaptor+Protein+Grb10+Interacts+Genetically+with+Nf1%2Fp53+in+Development+and+Tumorigenesis&rft.au=Reilly%2C+Karlyne+M%3BTuskan%2C+Robert%3BKumar%2C+Krishan%3BStewart%2C+Colin%3BHagan%2C+John%3BFox%2C+Kristi&rft.aulast=Reilly&rft.aufirst=Karlyne&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Growth of Alveolar Soft Part Sarcoma (ASPS) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968853; 4182169 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Vistica, David T AU - Kenney, Susan AU - Borgel, Suzanne D AU - Hollingshead, Melinda G AU - Wallqvist, Anders S AU - Covell, David G AU - Schrump, David S AU - Zhao, Ming AU - Krosky, Paula M AU - Stockwin, Luke H AU - Butcher, Donna O AU - Scudiero, Dominic A AU - Shoemaker, Robert H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Sarcoma KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Zenapax+Therapy+for+Uveitis&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging and Semiquantitation of Polycyclic Aromatic Hydrocarbon (PAH)-DNA Adducts in Human Cervix, Vulva, Placenta and Prostate Using Immunohistochemistry (IHC) and the Automated Cellular Imaging System (ACIS) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967776; 4185287 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pratt, M Margaret AU - Sirajuddin, Paul AU - Castle, Philip E AU - Phillips, David H AU - Afework, Senait AU - MacLean, Allen B AU - Ragavan, Narasimhan AU - Martin, Francis L AU - ram, Radim J AU - Manchester, David K AU - Olivero, Ofelia A AU - Poirier, Miriam C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Polycyclic aromatic hydrocarbons KW - Imaging techniques KW - Adducts KW - Cervix KW - Immunohistochemistry KW - Prostate KW - Vulva KW - Placenta KW - Aromatic hydrocarbons KW - Automation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Imaging+and+Semiquantitation+of+Polycyclic+Aromatic+Hydrocarbon+%28PAH%29-DNA+Adducts+in+Human+Cervix%2C+Vulva%2C+Placenta+and+Prostate+Using+Immunohistochemistry+%28IHC%29+and+the+Automated+Cellular+Imaging+System+%28ACIS%29&rft.au=Pratt%2C+M+Margaret%3BSirajuddin%2C+Paul%3BCastle%2C+Philip+E%3BPhillips%2C+David+H%3BAfework%2C+Senait%3BMacLean%2C+Allen+B%3BRagavan%2C+Narasimhan%3BMartin%2C+Francis+L%3Bram%2C+Radim+J%3BManchester%2C+David+K%3BOlivero%2C+Ofelia+A%3BPoirier%2C+Miriam+C&rft.aulast=Pratt&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Novel Prognostic Subtype of Hepatocellular Carcinoma Derived from Hepatic Stem Cells by Comparative Functional Genomic Approach T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967054; 4186161 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lee, Ju-Seog AU - Heo, Jeonghoon AU - Libbrecht, Louis AU - Chu, In-Sun AU - Kaposi-Novak, Pal AU - Calvisi, Diego F AU - Mikaelyan, Arsen AU - Roberts, Lewis R AU - Demetris, Anthony J AU - Sun, Zongtang AU - Nevens, Frederik AU - Roskams, Tania AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocellular carcinoma KW - Genomics KW - Stem cells KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Novel+Prognostic+Subtype+of+Hepatocellular+Carcinoma+Derived+from+Hepatic+Stem+Cells+by+Comparative+Functional+Genomic+Approach&rft.au=Lee%2C+Ju-Seog%3BHeo%2C+Jeonghoon%3BLibbrecht%2C+Louis%3BChu%2C+In-Sun%3BKaposi-Novak%2C+Pal%3BCalvisi%2C+Diego+F%3BMikaelyan%2C+Arsen%3BRoberts%2C+Lewis+R%3BDemetris%2C+Anthony+J%3BSun%2C+Zongtang%3BNevens%2C+Frederik%3BRoskams%2C+Tania%3BThorgeirsson%2C+Snorri+S&rft.aulast=Lee&rft.aufirst=Ju-Seog&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p53 Transactivation from Response Element Sequences within Cells may not Reflect In Vitro DNA Binding Ability T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966840; 4183199 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jordan, Jennifer J AU - Inga, Alberto AU - Darden, Thomas A AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Regulatory sequences KW - P53 protein KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=p53+Transactivation+from+Response+Element+Sequences+within+Cells+may+not+Reflect+In+Vitro+DNA+Binding+Ability&rft.au=Jordan%2C+Jennifer+J%3BInga%2C+Alberto%3BDarden%2C+Thomas+A%3BResnick%2C+Michael+A&rft.aulast=Jordan&rft.aufirst=Jennifer&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccines Containing Multiple Comstimulatory Molecules Promote the Proliferation and Activation of Human Antigen Specific Memory CD8 T Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964571; 4185921 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Sixun AU - Grosenbach, Doug AU - Schlom, Jeffrey Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Memory cells KW - Cell proliferation KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Cell activation KW - Antigens KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Vaccines+Containing+Multiple+Comstimulatory+Molecules+Promote+the+Proliferation+and+Activation+of+Human+Antigen+Specific+Memory+CD8+T+Cells&rft.au=Yang%2C+Sixun%3BGrosenbach%2C+Doug%3BSchlom%2C+Jeffrey&rft.aulast=Yang&rft.aufirst=Sixun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Keratin 14 Expression in Mouse Lung Induces Early Squamous Differentiation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964444; 4182127 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dakir, El Habib AU - Feigenbaum, Lionel AU - Linnoila, R Ilona Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Differentiation KW - Keratin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Keratin+14+Expression+in+Mouse+Lung+Induces+Early+Squamous+Differentiation&rft.au=Dakir%2C+El+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=El&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Tumor Suppressor Gene, hCas, Inhibits Neuroblastoma Tumorigenicity T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964031; 4182613 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Xuezhong AU - Liu, Zhihui AU - Barenloim-Stapleton, Linda AU - Ried, Thomas AU - London, Wendy AU - Maris, John AU - Thiele, Carol J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor suppressor genes KW - Tumorigenicity KW - Neuroblastoma KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Redundancy+of+DNA+helicases+in+p53-mediated+apoptosis.&rft.au=Spillare%2C+E+A%3BWang%2C+X+W%3Bvon+Kobbe%2C+C%3BBohr%2C+V+A%3BHickson%2C+I+D%3BHarris%2C+C+C&rft.aulast=Spillare&rft.aufirst=E&rft.date=2006-03-30&rft.volume=25&rft.issue=14&rft.spage=2119&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclin E Overexpression Correlates with Inflammation in Breast Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39958865; 4185205 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Howe, Tiffany M AU - Boersma, Brenda J AU - Goodman, Julie E AU - Yfantis, Harry G AU - Cottrell, John R AU - Prueitt, Robyn L AU - Bowman, Elise D AU - Lee, Dong H AU - Ambs, Stefan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Inflammation KW - Cyclin E UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cyclin+E+Overexpression+Correlates+with+Inflammation+in+Breast+Cancer&rft.au=Howe%2C+Tiffany+M%3BBoersma%2C+Brenda+J%3BGoodman%2C+Julie+E%3BYfantis%2C+Harry+G%3BCottrell%2C+John+R%3BPrueitt%2C+Robyn+L%3BBowman%2C+Elise+D%3BLee%2C+Dong+H%3BAmbs%2C+Stefan&rft.aulast=Howe&rft.aufirst=Tiffany&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Host Derived Insulin-Like Growth Factor I on Murine Osteosarcoma Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39958853; 4182224 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hong, Sung-Hyeok AU - Newman, Rachel AU - Hoffman, Karen AU - Mendoza, Arnulfo AU - Yakar, Shoshana AU - LeRoith, Derek AU - Helman, Lee AU - Khanna, Chand Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - Insulin-like growth factor I KW - Metastases KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Role+of+Host+Derived+Insulin-Like+Growth+Factor+I+on+Murine+Osteosarcoma+Metastasis&rft.au=Hong%2C+Sung-Hyeok%3BNewman%2C+Rachel%3BHoffman%2C+Karen%3BMendoza%2C+Arnulfo%3BYakar%2C+Shoshana%3BLeRoith%2C+Derek%3BHelman%2C+Lee%3BKhanna%2C+Chand&rft.aulast=Hong&rft.aufirst=Sung-Hyeok&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peripheral Blood Immunologic Phenotype of Population-Based Post-Menopausal Breast Cancer Cases and Matched Controls T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39956670; 4182776 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Goedert, James J AU - Kopp, William C AU - Pfeiffer, Ruth AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Ortaldo, John R Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Peripheral blood KW - Breast cancer KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Peripheral+Blood+Immunologic+Phenotype+of+Population-Based+Post-Menopausal+Breast+Cancer+Cases+and+Matched+Controls&rft.au=Goedert%2C+James+J%3BKopp%2C+William+C%3BPfeiffer%2C+Ruth%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BOrtaldo%2C+John+R&rft.aulast=Goedert&rft.aufirst=James&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Cells and the Natural History of Cervical HPV Infections T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955872; 4181894 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kovacic, Melinda Butsch AU - Kreimer, Aimee AU - Schiffman, Mark AU - ShermanMark, E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Infection KW - Historical account KW - Cervix UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Immune+Cells+and+the+Natural+History+of+Cervical+HPV+Infections&rft.au=Kovacic%2C+Melinda+Butsch%3BKreimer%2C+Aimee%3BSchiffman%2C+Mark%3BShermanMark%2C+E&rft.aulast=Kovacic&rft.aufirst=Melinda&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction in Frataxin Activates the p53 Stress Pathway: Implications for Friedreichs Ataxia T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955407; 4182428 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Halweg, Christopher J AU - Menendez, Daniel AU - Karthikeyan, Gopalakrishnan AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Stress KW - Friedreich's ataxia KW - P53 protein KW - Frataxin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Reduction+in+Frataxin+Activates+the+p53+Stress+Pathway%3A+Implications+for+Friedreichs+Ataxia&rft.au=Halweg%2C+Christopher+J%3BMenendez%2C+Daniel%3BKarthikeyan%2C+Gopalakrishnan%3BResnick%2C+Michael+A&rft.aulast=Halweg&rft.aufirst=Christopher&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of DLC-1 Tumor Suppressor Gene Expression in Breast Cancer Cells by Proapoptotic Dietary Flavone and its Potential Implication in Chemoprevetion T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955274; 4182990 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ullmannova, Veronika AU - Popescu, Nicolae C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Flavones KW - Tumor suppressor genes KW - Gene expression KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+DLC-1+Tumor+Suppressor+Gene+Expression+in+Breast+Cancer+Cells+by+Proapoptotic+Dietary+Flavone+and+its+Potential+Implication+in+Chemoprevetion&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicolae+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phased Gene Expression Profiles of the Cell Cycle in Human Leukemic Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949972; 4181567 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rustici, Gabriella AU - De Siervi, Adriana AU - Gardner, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Cell cycle KW - Leukemia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phased+Gene+Expression+Profiles+of+the+Cell+Cycle+in+Human+Leukemic+Cell+Lines&rft.au=Rustici%2C+Gabriella%3BDe+Siervi%2C+Adriana%3BGardner%2C+Kevin&rft.aulast=Rustici&rft.aufirst=Gabriella&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bisindolylmaleimide and Indolocarbazole Protein Kinase (PK) Inhibitors Reverse ABCG2-Mediated Drug Transport and Resistance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39944489; 4181960 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Robey, Robert W AU - Shukla, Suneet AU - Steadman, Kenneth AU - Ambudkar, Suresh V AU - Bates, Susan E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drug resistance KW - Protein kinase KW - Indolocarbazoles KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Bisindolylmaleimide+and+Indolocarbazole+Protein+Kinase+%28PK%29+Inhibitors+Reverse+ABCG2-Mediated+Drug+Transport+and+Resistance&rft.au=Robey%2C+Robert+W%3BShukla%2C+Suneet%3BSteadman%2C+Kenneth%3BAmbudkar%2C+Suresh+V%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication Checkpoint Selectivity for Late S Phase Cells Induced by Topoisomerase I Cleavage Complexes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39940984; 4185452 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Seiler, Jennifer A AU - Syed, Ali AU - Aladjem, Mirit I AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Replication KW - DNA topoisomerase KW - S phase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39940984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Barriers+to+Eye+Care%3A+Results+of+Qualitative+Research&rft.au=Alexander%2C+Robert&rft.aulast=Alexander&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mining the National Cancer Institutes Drug Screening Database in Search for Antineoplastics that Selectively Target MDR1/P-Glycoprotein-Overexpressing Cancer Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39934978; 4183772 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Szakacs, Gergely AU - Chu, Benjamin F AU - Ludwig, Joseph A AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Drugs KW - Drug screening KW - Databases KW - Screening KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mining+the+National+Cancer+Institutes+Drug+Screening+Database+in+Search+for+Antineoplastics+that+Selectively+Target+MDR1%2FP-Glycoprotein-Overexpressing+Cancer+Cells&rft.au=Szakacs%2C+Gergely%3BChu%2C+Benjamin+F%3BLudwig%2C+Joseph+A%3BGottesman%2C+Michael+M&rft.aulast=Szakacs&rft.aufirst=Gergely&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically Engineered Mouse Cancer Models and Translational Applications T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39932917; 4186438 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Marks, Cheryl L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Translation KW - Animal models KW - Genetic engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Genetically+Engineered+Mouse+Cancer+Models+and+Translational+Applications&rft.au=Marks%2C+Cheryl+L&rft.aulast=Marks&rft.aufirst=Cheryl&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Biomarkers of Arsenic Exposure and Toxicity in Urine Using SELDI Technology T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39929522; 4182812 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Moore, Lee E AU - Skibola, Christine F AU - Hegedus, Christine AU - Skibola, Danica R AU - Pfeiffer, Ruth AU - Warner, Marcella AU - Clark, Michael AU - Steinmaus, Craig AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Smith, Martyn T AU - Smith, Allan H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Heavy metals KW - Bioindicators KW - Arsenic KW - Urine KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Biomarkers+of+Arsenic+Exposure+and+Toxicity+in+Urine+Using+SELDI+Technology&rft.au=Moore%2C+Lee+E%3BSkibola%2C+Christine+F%3BHegedus%2C+Christine%3BSkibola%2C+Danica+R%3BPfeiffer%2C+Ruth%3BWarner%2C+Marcella%3BClark%2C+Michael%3BSteinmaus%2C+Craig%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T%3BSmith%2C+Allan+H&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Study and Application of RNAi Against Cancer-Related Genes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928987; 4186075 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Martin, Scott E AU - Jones, Tamara L AU - Thomas, Cheryl L AU - Nguyen, Dac AU - Runfola, Timothy AU - Szakacs, Gergely AU - Gottesman, Michael M AU - Ludwig, Joseph A AU - Weinstein, John N AU - Gunsior, Michele AU - Goldsmith, Paul AU - Lader, Eric AU - Huppi, Konrad AU - Caplen, Natasha J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - RNA-mediated interference UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Study+and+Application+of+RNAi+Against+Cancer-Related+Genes&rft.au=Martin%2C+Scott+E%3BJones%2C+Tamara+L%3BThomas%2C+Cheryl+L%3BNguyen%2C+Dac%3BRunfola%2C+Timothy%3BSzakacs%2C+Gergely%3BGottesman%2C+Michael+M%3BLudwig%2C+Joseph+A%3BWeinstein%2C+John+N%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul%3BLader%2C+Eric%3BHuppi%2C+Konrad%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Haplotype Block in IGF2R Associated with Increased Risk For Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928596; 4187192 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Savage, Sharon A AU - Modi, William S AU - Douglass, Chester AU - Hoover, Robert N AU - Chanock, Stephen J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - Insulin-like growth factor II receptors KW - Haplotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+a+Haplotype+Block+in+IGF2R+Associated+with+Increased+Risk+For+Osteosarcoma&rft.au=Savage%2C+Sharon+A%3BModi%2C+William+S%3BDouglass%2C+Chester%3BHoover%2C+Robert+N%3BChanock%2C+Stephen+J&rft.aulast=Savage&rft.aufirst=Sharon&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Matrix: A Gatekeeper in the Transition from Dormancy to Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39927780; 4186758 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Barkan, Dalit AU - Costes, Sylvain V AU - Cho, Edward H AU - Simmons, Justin L AU - Asmussen, Holly AU - Kamaraju, Anil K AU - Hoenorhoff, Mark AU - Lockett, Stephen AU - Kleinman, Hynda AU - Chambers, Ann AU - Green, Jeffrey E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Extracellular matrix KW - Metastases KW - Dormancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Post-Operative+Serum+Cortisol+for+Prediction+of+Long-Term+Remission+from+Cushing%27s+Syndrome&rft.au=Lindsay%2C+J+R%3BOldfield%2C+E+H%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleotide Damage Proximal to DNA Double-Strand Break ends is a Stronger Inhibitor of Non-Homologous end Joining than Blocked 3 Ends T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39925603; 4186637 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Datta, Kamal AU - Neumann, Ronald D AU - Winters, Thomas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Non-homologous end joining KW - Nucleotides KW - DNA damage KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nucleotide+Damage+Proximal+to+DNA+Double-Strand+Break+ends+is+a+Stronger+Inhibitor+of+Non-Homologous+end+Joining+than+Blocked+3+Ends&rft.au=Datta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Datta&rft.aufirst=Kamal&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Network Profiling of Multiple Myeloma Bone Marrow Aspirates Using Reverse Phase Protein Microarrays T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39922371; 4184817 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sheehan, Katherine M AU - Burington, Bart AU - Rasmussen, Erik AU - Crowley, John AU - Huang, Yongsheng AU - Tricot, Guido AU - Barlogie, Bart AU - Shaughnessy Jr, John D AU - Gulmann, Christian AU - Kay, Elaine W AU - Wulfkuhle, Julia D AU - Liotta, Lance A AU - Petricoin III, Emanuel F. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bone marrow KW - Protein arrays KW - Multiple myeloma KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Network+Profiling+of+Multiple+Myeloma+Bone+Marrow+Aspirates+Using+Reverse+Phase+Protein+Microarrays&rft.au=Sheehan%2C+Katherine+M%3BBurington%2C+Bart%3BRasmussen%2C+Erik%3BCrowley%2C+John%3BHuang%2C+Yongsheng%3BTricot%2C+Guido%3BBarlogie%2C+Bart%3BShaughnessy+Jr%2C+John+D%3BGulmann%2C+Christian%3BKay%2C+Elaine+W%3BWulfkuhle%2C+Julia+D%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Sheehan&rft.aufirst=Katherine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor-Induced Downregulation of Interferon Consensus Sequence Binding Protein (ICSBP) in CD11b+Gr-1+ Myeloid Suppressor Cells may Underlie a Mechanism for their Aberrant Expansion and Function T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39922014; 4183046 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Greeneltch, Kristy M AU - Stewart, Trina J AU - Schneider, Monika AU - Liu, Kebin AU - Abrams, Scott I Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Conserved sequence KW - Interferon KW - CD11b antigen KW - Amino acid sequence KW - Suppressor cells KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Tumor-Induced+Downregulation+of+Interferon+Consensus+Sequence+Binding+Protein+%28ICSBP%29+in+CD11b%2BGr-1%2B+Myeloid+Suppressor+Cells+may+Underlie+a+Mechanism+for+their+Aberrant+Expansion+and+Function&rft.au=Greeneltch%2C+Kristy+M%3BStewart%2C+Trina+J%3BSchneider%2C+Monika%3BLiu%2C+Kebin%3BAbrams%2C+Scott+I&rft.aulast=Greeneltch&rft.aufirst=Kristy&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations of the Biophysical Milieu of Membranes Induce Conformational Changes Into Membrane Bound P-Glycoprotein T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39920864; 4183785 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Aszalos, Adorjan AU - Taylor, Barbara AU - Yin, Jun-Jie AU - Chen, Kevin G AU - Cardarelli, Carol AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Membranes KW - P-Glycoprotein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Alterations+of+the+Biophysical+Milieu+of+Membranes+Induce+Conformational+Changes+Into+Membrane+Bound+P-Glycoprotein&rft.au=Aszalos%2C+Adorjan%3BTaylor%2C+Barbara%3BYin%2C+Jun-Jie%3BChen%2C+Kevin+G%3BCardarelli%2C+Carol%3BGottesman%2C+Michael+M&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro and In Vivo Effects of CXCR4 Inhibition in Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39920381; 4182208 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, Su Young AU - Midura, Brieanne V AU - Mendoza, Arnulfo AU - Khanna, Chand AU - Korz, Walter AU - Wong, Donald AU - Salari, Hassan AU - Helman, Lee J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - CXCR4 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=In+Vitro+and+In+Vivo+Effects+of+CXCR4+Inhibition+in+Osteosarcoma&rft.au=Kim%2C+Su+Young%3BMidura%2C+Brieanne+V%3BMendoza%2C+Arnulfo%3BKhanna%2C+Chand%3BKorz%2C+Walter%3BWong%2C+Donald%3BSalari%2C+Hassan%3BHelman%2C+Lee+J&rft.aulast=Kim&rft.aufirst=Su&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Pathogenesis of Human Hepatocellular Carcinoma: Mechanistic and Prognostic Significance of Aberrant Methylation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39918121; 4182490 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Calvisi, Diego F AU - Ladu, Sara AU - Gorden, Alexis AU - Farina, Miriam AU - Lee, Ju-Seog AU - Conner, Elizabeth A AU - Schroeder, Insa S AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocellular carcinoma KW - Methylation KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Pathogenesis+of+Human+Hepatocellular+Carcinoma%3A+Mechanistic+and+Prognostic+Significance+of+Aberrant+Methylation&rft.au=Calvisi%2C+Diego+F%3BLadu%2C+Sara%3BGorden%2C+Alexis%3BFarina%2C+Miriam%3BLee%2C+Ju-Seog%3BConner%2C+Elizabeth+A%3BSchroeder%2C+Insa+S%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Calvisi&rft.aufirst=Diego&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sustained Expression of Mect1-Maml2 is Essential for Viability of Salivary Gland Tumors Carrying the t(11;19) Translocation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39917888; 4182392 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Komiya, Takefumi AU - Park, Yoonsoo AU - Modi, Sanjay AU - Coxon, Amy AU - Oh, Hye AU - Kaye, Frederic Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Salivary gland KW - Translocation KW - Tumors KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Sustained+Expression+of+Mect1-Maml2+is+Essential+for+Viability+of+Salivary+Gland+Tumors+Carrying+the+t%2811%3B19%29+Translocation&rft.au=Komiya%2C+Takefumi%3BPark%2C+Yoonsoo%3BModi%2C+Sanjay%3BCoxon%2C+Amy%3BOh%2C+Hye%3BKaye%2C+Frederic&rft.aulast=Komiya&rft.aufirst=Takefumi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of Cancer Disparities: Barriers to Cancer Screening, Diagnosis, and Treatment T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39896060; 4183299 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chu, Kenneth C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Screening KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Determinants+of+Cancer+Disparities%3A+Barriers+to+Cancer+Screening%2C+Diagnosis%2C+and+Treatment&rft.au=Chu%2C+Kenneth+C&rft.aulast=Chu&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Topoisomerase I-DNA Complexes: An Early and General Process of Programmed Cell Death Induced by TRAIL, Fas, Tubulin Inhibitors, BH3 Mimetics and DNA Targeted Agents T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39894428; 4185493 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sordet, Olivier AU - Rao, Ashutosh V AU - Goldman, Abby AU - Almanza, Carlos AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mortality KW - Apoptosis KW - CD95 antigen KW - TRAIL protein KW - Tubulin KW - Fas antigen KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Apoptotic+Topoisomerase+I-DNA+Complexes%3A+An+Early+and+General+Process+of+Programmed+Cell+Death+Induced+by+TRAIL%2C+Fas%2C+Tubulin+Inhibitors%2C+BH3+Mimetics+and+DNA+Targeted+Agents&rft.au=Sordet%2C+Olivier%3BRao%2C+Ashutosh+V%3BGoldman%2C+Abby%3BAlmanza%2C+Carlos%3BPommier%2C+Yves&rft.aulast=Sordet&rft.aufirst=Olivier&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxic Gene Therapy of Esophageal Cancers Using the Recombinant RGD-Modified Adenovirus Expressing Membrane-Bound TRAIL (TNF-Related Apoptosis-Inducing Ligand): An In Vitro and In Vivo Analysis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39893714; 4187308 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Nguyen, Duc M AU - Sehgal, Shailen AU - Fang, Bingliang AU - Schrump, David S AU - Nguyen, Dao M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - TRAIL protein KW - Cytotoxicity KW - Gene therapy KW - Ligands KW - Recombinants KW - Adenovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cytotoxic+Gene+Therapy+of+Esophageal+Cancers+Using+the+Recombinant+RGD-Modified+Adenovirus+Expressing+Membrane-Bound+TRAIL+%28TNF-Related+Apoptosis-Inducing+Ligand%29%3A+An+In+Vitro+and+In+Vivo+Analysis&rft.au=Yeow%2C+Wen-Shuz%3BChua%2C+Alex%3BNguyen%2C+Duc+M%3BSehgal%2C+Shailen%3BFang%2C+Bingliang%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Yeow&rft.aufirst=Wen-Shuz&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemoprevention and Therapeutic Treatment of BRCA1 Associated Breast Cancer in Conditional Knockout Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892871; 4182102 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Tominaga, Yohei AU - De Soto III, Joseph A. AU - Wang, Rui-Hong AU - Deng, Chu-Xia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Breast cancer KW - BRCA1 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chemoprevention+and+Therapeutic+Treatment+of+BRCA1+Associated+Breast+Cancer+in+Conditional+Knockout+Mice&rft.au=Tominaga%2C+Yohei%3BDe+Soto+III%2C+Joseph+A.%3BWang%2C+Rui-Hong%3BDeng%2C+Chu-Xia&rft.aulast=Tominaga&rft.aufirst=Yohei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Menopausal Hormone Therapy and Ovarian Cancer Risk T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892288; 4181891 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lacey Jr, James V AU - Brinton, Louise A AU - Leitzmann, Michael F AU - Mouw, Traci AU - Hartge, Patricia AU - Hollenbeck, Albert R AU - Schatzkin, Arthur Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Hormones KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Menopausal+Hormone+Therapy+and+Ovarian+Cancer+Risk&rft.au=Lacey+Jr%2C+James+V%3BBrinton%2C+Louise+A%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BHartge%2C+Patricia%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Lacey+Jr&rft.aufirst=James&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Patterns Distinguish Human Aberrant Crypt Foci from Normal Colonic Mucosa T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892004; 4181798 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Glebov, Oleg K AU - Rodriguez, Luz M AU - Soballe, Peter AU - DeNobile, John AU - Cliatt, Janet AU - Nakahara, Kenneth AU - Kirsch, Ilan R Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Mucosa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Gene+Expression+Patterns+Distinguish+Human+Aberrant+Crypt+Foci+from+Normal+Colonic+Mucosa&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaphostin Induced Toxicity in Lung Tumor Cell Lines Implicates Oxidative Stress that is Mediated through the Nrf-2/Heme Oxygenase Pathway T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39891314; 4184048 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reifsnider, Nicole D AU - Hose, Curtis D AU - Monks, Anne Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Lung KW - Stress KW - GA-binding protein KW - Oxidative stress KW - Tumor cell lines KW - Heme oxygenase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Adaphostin+Induced+Toxicity+in+Lung+Tumor+Cell+Lines+Implicates+Oxidative+Stress+that+is+Mediated+through+the+Nrf-2%2FHeme+Oxygenase+Pathway&rft.au=Reifsnider%2C+Nicole+D%3BHose%2C+Curtis+D%3BMonks%2C+Anne&rft.aulast=Reifsnider&rft.aufirst=Nicole&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cox-2 and Other Inflammatory Response Proteins Mediate Prevention of Human Papilloma Virus (HPV) E7-Driven Tumorigenesis by Dominant Negative Cjun (TAM67) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885984; 4184854 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Matthews, Connie P AU - Young, Matthew R AU - Colburn, Nancy H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prevention KW - Tumorigenesis KW - Inflammation KW - Cyclooxygenase-2 KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cox-2+and+Other+Inflammatory+Response+Proteins+Mediate+Prevention+of+Human+Papilloma+Virus+%28HPV%29+E7-Driven+Tumorigenesis+by+Dominant+Negative+Cjun+%28TAM67%29&rft.au=Matthews%2C+Connie+P%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H&rft.aulast=Matthews&rft.aufirst=Connie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo Molecular Imaging of Disseminated Peritoneal Cancer Microfoci Using a Targeted Optical Fluorescence Agent Conjugated to Avidin T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885354; 4184728 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Kamiya, Mako AU - Bernardo, Marcelino AU - Paik, Ronald S AU - Krishna, Murali C AU - Choyke, Peter L AU - Kobayashi, Hisataka Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Fluorescence KW - Cancer KW - Imaging techniques KW - Avidin KW - Peritoneum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=In+vivo+Molecular+Imaging+of+Disseminated+Peritoneal+Cancer+Microfoci+Using+a+Targeted+Optical+Fluorescence+Agent+Conjugated+to+Avidin&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BKamiya%2C+Mako%3BBernardo%2C+Marcelino%3BPaik%2C+Ronald+S%3BKrishna%2C+Murali+C%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overexpression of BP1 Confers a More Aggressive Phenotype on MCF7 Breast Cancer Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39884248; 4185068 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ginsburg, Erika AU - Fu, Sidney AU - Campbell, Cassandra L AU - Baxter, Kristin K AU - Kluk, Brian AU - Vonderhaar, Barbara AU - Berg, Patricia E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Overexpression+of+BP1+Confers+a+More+Aggressive+Phenotype+on+MCF7+Breast+Cancer+Cells&rft.au=Ginsburg%2C+Erika%3BFu%2C+Sidney%3BCampbell%2C+Cassandra+L%3BBaxter%2C+Kristin+K%3BKluk%2C+Brian%3BVonderhaar%2C+Barbara%3BBerg%2C+Patricia+E&rft.aulast=Ginsburg&rft.aufirst=Erika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of ETS Transcription Factors in the HIF-2 Target Gene Selection T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879726; 4186080 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Aprelikova, Olga AU - Wood, Matthew AU - Tackett, Sean AU - Chandramouli, G.V.R. AU - Barrett, J.Carl Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - ETS protein KW - Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Role+of+ETS+Transcription+Factors+in+the+HIF-2+Target+Gene+Selection&rft.au=Aprelikova%2C+Olga%3BWood%2C+Matthew%3BTackett%2C+Sean%3BChandramouli%2C+G.V.R.%3BBarrett%2C+J.Carl&rft.aulast=Aprelikova&rft.aufirst=Olga&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age-Related Eye Diseases Study (AREDS): Past Findings and Current Efforts, and How it Relates to Public Health T2 - 3rd Annual International Health Conference of the Unite For Sight AN - 39879615; 4194585 JF - 3rd Annual International Health Conference of the Unite For Sight AU - Huang, Lynn L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Public health KW - Eye diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Age-Related+Eye+Diseases+Study+%28AREDS%29%3A+Past+Findings+and+Current+Efforts%2C+and+How+it+Relates+to+Public+Health&rft.au=Huang%2C+Lynn+L&rft.aulast=Huang&rft.aufirst=Lynn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.uniteforsight.org/2006_annual_conference.php#cliffocallahan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Role of Elevated PhosphoSTAT5a in 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine-Induced Rat Mammary Gland Carcinomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879324; 4185994 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Papaconstantinou, Andriana D AU - Snyderwine, Elizabeth G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mammary gland KW - Carcinoma KW - Tumors KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Possible+Role+of+Elevated+PhosphoSTAT5a+in+2-Amino-1-Methyl-6-Phenylimidazo%5B4%2C5-b%5DPyridine-Induced+Rat+Mammary+Gland+Carcinomas&rft.au=Papaconstantinou%2C+Andriana+D%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opening Comments on the NanoAlliance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39877670; 4181542 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Barker, Anna D Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Global+Gene+Expression+Profiling+of+Mucinous+Ovarian+Tumors+and+Cystadenomas+Identifies+Genes+of+Clinicopathologic+Importance&rft.au=Wamunyokoli%2C+Fred+W+A%3BBonome%2C+Tomas%3BLee%2C+Ji-Young%3BFeltmate%2C+Colleen+M%3BWelch%2C+William+R%3BRadonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBrady%2C+John%3BHao%2C+Ke%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel%3BBirrer%2C+Michael+J&rft.aulast=Wamunyokoli&rft.aufirst=Fred+W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of MAP3K8 Levels in Lung Cancer Cell Lines and the Effects on Downstream Pathways T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39876311; 4183418 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dempsey, Jamie M AU - Pandey, Jyotsna AU - Gunsior, Michele AU - Goldsmith, Paul AU - Wiest, Jonathan S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Tumor cell lines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Differential+Expression+of+MAP3K8+Levels+in+Lung+Cancer+Cell+Lines+and+the+Effects+on+Downstream+Pathways&rft.au=Dempsey%2C+Jamie+M%3BPandey%2C+Jyotsna%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul%3BWiest%2C+Jonathan+S&rft.aulast=Dempsey&rft.aufirst=Jamie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV Protease Inhibitors as Cancer Therapeutics: Is Off-The-Shelf Right on Target? T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39860099; 4184513 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Gills, Joell J AU - Lopiccolo, Jaclyn AU - Abu-Asab, Mones S AU - Shoemaker, Robert AU - Borojerdi, Jennifer AU - Dennis, Phillip A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Proteinase inhibitors KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=HIV+Protease+Inhibitors+as+Cancer+Therapeutics%3A+Is+Off-The-Shelf+Right+on+Target%3F&rft.au=Gills%2C+Joell+J%3BLopiccolo%2C+Jaclyn%3BAbu-Asab%2C+Mones+S%3BShoemaker%2C+Robert%3BBorojerdi%2C+Jennifer%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Closing Remarks and Introduction of Mentors T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39859339; 4186552 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Johnson, Alfred C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Closing+Remarks+and+Introduction+of+Mentors&rft.au=Johnson%2C+Alfred+C&rft.aulast=Johnson&rft.aufirst=Alfred&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Redundancy of DNA helicases in p53-mediated apoptosis. AN - 67811986; 16288211 AB - A subset of DNA helicases, the RecQ family, has been found to be associated with the p53-mediated apoptotic pathway and is involved in maintaining genomic integrity. This family contains the BLM and WRN helicases, in which germline mutations are responsible for Bloom and Werner syndromes, respectively. TFIIH DNA helicases, XPB and XPD, are also components in this apoptotic pathway. We hypothesized that there may be some redundancy between helicases in their ability to complement the attenuated p53-mediated apoptotic levels seen in cells from individuals with diseases associated with these defective helicase genes. The attenuated apoptotic phenotype in Bloom syndrome cells was rescued not only by ectopic expression of BLM, but also by WRN or XPB, both 3' --> 5' helicases, but not expression of the 5' --> 3' helicase XPD. Overexpression of Sgs1, a WRN/BLM yeast homolog, corrected the reduction in BS cells only, which is consistent with Sgs1 being evolutionarily most homologous to BLM. A restoration of apoptotic levels in cells from WS, XPB or XPD patients was attained only by overexpression of the specific helicase. Our data suggest a limited redundancy in the pathways of these RecQ helicases in p53-induced apoptosis. JF - Oncogene AU - Spillare, E A AU - Wang, X W AU - von Kobbe, C AU - Bohr, V A AU - Hickson, I D AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 SP - 2119 EP - 2123 VL - 25 IS - 14 SN - 0950-9232, 0950-9232 KW - Tumor Suppressor Protein p53 KW - 0 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Werner Syndrome -- enzymology KW - Humans KW - Germ-Line Mutation KW - Bloom Syndrome -- enzymology KW - Tumor Suppressor Protein p53 -- physiology KW - DNA Helicases -- metabolism KW - Apoptosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67811986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Redundancy+of+DNA+helicases+in+p53-mediated+apoptosis.&rft.au=Spillare%2C+E+A%3BWang%2C+X+W%3Bvon+Kobbe%2C+C%3BBohr%2C+V+A%3BHickson%2C+I+D%3BHarris%2C+C+C&rft.aulast=Spillare&rft.aufirst=E&rft.date=2006-03-30&rft.volume=25&rft.issue=14&rft.spage=2119&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-26 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2001 Aug;8(2):351-61 [11545737] Cancer Res. 2005 Jul 1;65(13):5520-2 [15994923] Acta Oncol. 2001;40(6):696-701 [11765063] J Biol Chem. 2002 Jun 14;277(24):22035-44 [11919194] Mutat Res. 2002 Jul 25;504(1-2):157-72 [12106656] Mol Cell Biol. 2002 Oct;22(20):6971-8 [12242278] J Biol Chem. 2002 Oct 25;277(43):41110-9 [12181313] Hum Mol Genet. 2002 Dec 1;11(25):3135-44 [12444098] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] Genes Cells. 1999 Nov;4(11):619-25 [10620009] J Biol Chem. 2000 Feb 11;275(6):4258-66 [10660593] Mutat Res. 2000 Apr 28;459(3):203-9 [10812332] J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Cytogenet Cell Genet. 2000;91(1-4):217-23 [11173860] EMBO J. 2001 Feb 15;20(4):905-13 [11179234] J Biol Chem. 2001 Aug 31;276(35):32948-55 [11399766] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] J Cell Sci. 2003 Oct 15;116(Pt 20):4077-85 [12972501] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Oncogene. 2004 Jan 8;23(1):149-56 [14712220] Trends Pharmacol Sci. 2004 Apr;25(4):177-81 [15116721] Eur J Biochem. 2004 May;271(10):1849-63 [15128295] Carcinogenesis. 2004 Jul;25(7):1077-81 [15205365] Cell. 1990 Aug 24;62(4):777-91 [2167179] EMBO J. 1994 Apr 1;13(7):1645-53 [8157004] Genes Dev. 1996 May 15;10(10):1219-32 [8675009] EMBO J. 1996 Jul 15;15(14):3693-701 [8758936] Genetics. 1996 Nov;144(3):935-45 [8913739] Cell. 1997 Feb 7;88(3):323-31 [9039259] EMBO J. 1997 Oct 1;16(19):5955-65 [9312053] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8733-8 [9671747] EMBO J. 1999 Mar 1;18(5):1357-66 [10064601] Mol Biol Cell. 1999 Mar;10(3):665-76 [10069810] Genes Dev. 1999 Jun 1;13(11):1355-60 [10364153] J Biol Chem. 1999 Jun 25;274(26):18341-50 [10373438] J Biol Chem. 1999 Aug 6;274(32):22127-30 [10428772] Annu Rev Genomics Hum Genet. 2000;1:409-59 [11701636] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Clinical Approach to Diagnosing Immune Mechanisms of Ocular Surface Disease T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40159915; 4148097 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Smith, J A AU - Reed, G AU - Vitale, S AU - Chan, C-C Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Immunology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40159915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Clinical+Approach+to+Diagnosing+Immune+Mechanisms+of+Ocular+Surface+Disease&rft.au=Smith%2C+J+A%3BReed%2C+G%3BVitale%2C+S%3BChan%2C+C-C&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Blindness Despite Steroid Therapy T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40143795; 4148032 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Nussenblatt, R B Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Blindness KW - Steroid hormones KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40143795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Prevalence+of+Blindness+Despite+Steroid+Therapy&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Nutrition and Supplementation in Age-Related Macular Degeneration T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40125960; 4148051 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Cooney, M J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Nutrition KW - Supplementation KW - Macular degeneration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40125960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=The+Role+of+Nutrition+and+Supplementation+in+Age-Related+Macular+Degeneration&rft.au=Cooney%2C+M+J&rft.aulast=Cooney&rft.aufirst=M&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Zenapax Therapy for Uveitis T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40101566; 4148023 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Nussenblatt, R B Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Uveitis KW - Zenapax KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Zenapax+Therapy+for+Uveitis&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CT-Integrated Treatment Planning for Thermal Ablation with Intraprocedural Adaptive Modifications. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 40006847; 4208904 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Wood, B AU - Bauer, C AU - Viswanathan, A AU - Kruecker, J AU - Haemmerich, D AU - Yanof, J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Possible+Role+of+Elevated+PhosphoSTAT5a+in+2-Amino-1-Methyl-6-Phenylimidazo%5B4%2C5-b%5DPyridine-Induced+Rat+Mammary+Gland+Carcinomas&rft.au=Papaconstantinou%2C+Andriana+D%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diagnostic and Interventional CT Shielding: A Dramatic Decrease in Scattered Radiation for Patients. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39995809; 4208837 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Neeman, Z AU - Jacobus, J AU - Oberoi, J AU - Sudheendra, D AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Diagnostic+and+Interventional+CT+Shielding%3A+A+Dramatic+Decrease+in+Scattered+Radiation+for+Patients.&rft.au=Neeman%2C+Z%3BJacobus%2C+J%3BOberoi%2C+J%3BSudheendra%2C+D%3BWood%2C+B+J&rft.aulast=Neeman&rft.aufirst=Z&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electromagnetic Tracking of Surgical Devices for Multimodality Navigation during Interventions. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39990474; 4208706 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Viswanathan, A AU - Glossop, N AU - Kruecker, J AU - Xu, S. AU - Locklin, J AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39990474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Electromagnetic+Tracking+of+Surgical+Devices+for+Multimodality+Navigation+during+Interventions.&rft.au=Viswanathan%2C+A%3BGlossop%2C+N%3BKruecker%2C+J%3BXu%2C+S.%3BLocklin%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Evaluation of Haptic Feedback Tools for CT-Guided Robotic Interventions. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39953154; 4208894 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Viswanathan, A AU - Yanof, J H AU - Bauer, C AU - Xu, S. AU - Kruecker, J AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Robotics KW - Feedback KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39953154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Preliminary+Evaluation+of+Haptic+Feedback+Tools+for+CT-Guided+Robotic+Interventions.&rft.au=Viswanathan%2C+A%3BYanof%2C+J+H%3BBauer%2C+C%3BXu%2C+S.%3BKruecker%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of the Crossover Outcome of Meiotic Recombination T2 - 2006 Conference of the Biochemical Society and the Genetics Society on Meiosis AN - 40065575; 4219203 JF - 2006 Conference of the Biochemical Society and the Genetics Society on Meiosis AU - Lichten, Michael Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Recombination KW - Meiosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40065575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Aryl+Hydrocarbon+Receptor+Repressor%2C+a+Candidate+Tumor+Suppressor+Gene&rft.au=Zudaire%2C+Enrique%3BCuesta%2C+Natalia%3BMurty%2C+Vundavalli%3BMartinez%2C+Alfredo%3BNarayan%2C+Gopeshwar%3BBirrer%2C+Mike%3BKirsch%2C+IlanR%3BCuttitta%2C+Frank&rft.aulast=Zudaire&rft.aufirst=Enrique&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biochemistry.org/meetings/programme.cfm?Meeting_No=SA049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Pattern of H4AcK16 Location on the Male X Chromosome T2 - 47th Annual Drosophila Research Conference AN - 40041079; 4195248 JF - 47th Annual Drosophila Research Conference AU - Zhang, Yu AU - Gupta, Vaijayanti AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Chromosomes KW - X chromosome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40041079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Global+Pattern+of+H4AcK16+Location+on+the+Male+X+Chromosome&rft.au=Zhang%2C+Yu%3BGupta%2C+Vaijayanti%3BOliver%2C+Brian&rft.aulast=Zhang&rft.aufirst=Yu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Foiled Coil Gene is Required for Testis Elongation and Coiling T2 - 47th Annual Drosophila Research Conference AN - 40040788; 4195122 JF - 47th Annual Drosophila Research Conference AU - Smith, John AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Coiling KW - Elongation KW - Testes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Foiled+Coil+Gene+is+Required+for+Testis+Elongation+and+Coiling&rft.au=Smith%2C+John%3BOliver%2C+Brian&rft.aulast=Smith&rft.aufirst=John&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is there a Telomere-Linked Stress Response in Drosophila? T2 - 47th Annual Drosophila Research Conference AN - 40037285; 4195246 JF - 47th Annual Drosophila Research Conference AU - Mason, James M AU - Biessmann, Harald AU - Walter, Marika F AU - Bradley, Tim Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Stress KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Is+there+a+Telomere-Linked+Stress+Response+in+Drosophila%3F&rft.au=Mason%2C+James+M%3BBiessmann%2C+Harald%3BWalter%2C+Marika+F%3BBradley%2C+Tim&rft.aulast=Mason&rft.aufirst=James&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pairing-Sensitive Elements Regulate Polycomb Responsiveness and Enhancer-Promoter Interactions at the Drosophila engrailed gene T2 - 47th Annual Drosophila Research Conference AN - 40035283; 4195259 JF - 47th Annual Drosophila Research Conference AU - Kassis, Judith AU - DeVido, Sarah AU - Kwon, Deborah Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Engrailed gene KW - Polycomb group proteins KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40035283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Pairing-Sensitive+Elements+Regulate+Polycomb+Responsiveness+and+Enhancer-Promoter+Interactions+at+the+Drosophila+engrailed+gene&rft.au=Kassis%2C+Judith%3BDeVido%2C+Sarah%3BKwon%2C+Deborah&rft.aulast=Kassis&rft.aufirst=Judith&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Drosophila Lipid Droplet-Associated Proteins T2 - 47th Annual Drosophila Research Conference AN - 40028186; 4195596 JF - 47th Annual Drosophila Research Conference AU - Beller, Mathias AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Lipids KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40028186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Opening+Comments+on+the+NanoAlliance&rft.au=Barker%2C+Anna+D&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decoding CIS-Regulatory Sequences Involved in Neural Precursor Coordinate Gene Regulation T2 - 47th Annual Drosophila Research Conference AN - 40027783; 4195677 JF - 47th Annual Drosophila Research Conference AU - Brody, Thomas AU - Rasband, Wayne AU - Baler, Kevin AU - Kuzin, Alexander AU - Odenwald, Ward Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Decoding+CIS-Regulatory+Sequences+Involved+in+Neural+Precursor+Coordinate+Gene+Regulation&rft.au=Brody%2C+Thomas%3BRasband%2C+Wayne%3BBaler%2C+Kevin%3BKuzin%2C+Alexander%3BOdenwald%2C+Ward&rft.aulast=Brody&rft.aufirst=Thomas&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishing the Incidence of Putative Genetic Modifiers in DNA Samples of Newborns with Sickle Cell Disease from a State Newborn Screening Program T2 - 67th Annual Meeting of the Association of Southeastern Biologists (ASB 2006) AN - 40002283; 4205861 JF - 67th Annual Meeting of the Association of Southeastern Biologists (ASB 2006) AU - Cobb, Crystal AU - Ackah, Diana AU - Carolyn, Hoppe M.D. AU - James, G. Taylor VI M.D. Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Neonates KW - Sickle cell disease KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.atitle=Establishing+the+Incidence+of+Putative+Genetic+Modifiers+in+DNA+Samples+of+Newborns+with+Sickle+Cell+Disease+from+a+State+Newborn+Screening+Program&rft.au=Cobb%2C+Crystal%3BAckah%2C+Diana%3BCarolyn%2C+Hoppe+M.D.%3BJames%2C+G.+Taylor+VI+M.D.&rft.aulast=Cobb&rft.aufirst=Crystal&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asb.appstate.edu/ASB%202006%20schedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Dynamin Function in Membrane Trafficking during Early Drosophila Embryogenesis T2 - 47th Annual Drosophila Research Conference AN - 39996510; 4194988 JF - 47th Annual Drosophila Research Conference AU - Rikhy, Richa AU - Mavrakis, Manos AU - Lippincott-Schwartz, Jennifer Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Membranes KW - Embryogenesis KW - Dynamin KW - Membrane trafficking KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39996510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Characterization+of+Dynamin+Function+in+Membrane+Trafficking+during+Early+Drosophila+Embryogenesis&rft.au=Rikhy%2C+Richa%3BMavrakis%2C+Manos%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Rikhy&rft.aufirst=Richa&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An O-Glycosyltransferase is Required during Multiple Stages of Drosophila Development T2 - 47th Annual Drosophila Research Conference AN - 39993632; 4195455 JF - 47th Annual Drosophila Research Conference AU - Tian, E AU - Hagen, Kelly G. Ten Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Developmental stages KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=An+O-Glycosyltransferase+is+Required+during+Multiple+Stages+of+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nerfin-1 Gene and mRNA Regulation: Enhancer and miRNA Analysis T2 - 47th Annual Drosophila Research Conference AN - 39993440; 4195425 JF - 47th Annual Drosophila Research Conference AU - Kuzin, Alexander AU - Kundu, Mukta AU - Brody, Thomas AU - Odenwald, Ward F Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - MiRNA KW - Transcription KW - Enhancers KW - Gene regulation KW - MRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Nerfin-1+Gene+and+mRNA+Regulation%3A+Enhancer+and+miRNA+Analysis&rft.au=Kuzin%2C+Alexander%3BKundu%2C+Mukta%3BBrody%2C+Thomas%3BOdenwald%2C+Ward+F&rft.aulast=Kuzin&rft.aufirst=Alexander&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Terminal Telomeric Region is Euchromatic in Drosophila melanogaster T2 - 47th Annual Drosophila Research Conference AN - 39987334; 4195244 JF - 47th Annual Drosophila Research Conference AU - Prasad, Sudha AU - Biessmann, Harald AU - Semeshin, Valery F AU - Andreyeva, Eugenia N AU - Walter, Marika F AU - Nguyen, Quang AU - Mason, James M Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Chromosomes KW - Genomes KW - Drosophila melanogaster UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Terminal+Telomeric+Region+is+Euchromatic+in+Drosophila+melanogaster&rft.au=Prasad%2C+Sudha%3BBiessmann%2C+Harald%3BSemeshin%2C+Valery+F%3BAndreyeva%2C+Eugenia+N%3BWalter%2C+Marika+F%3BNguyen%2C+Quang%3BMason%2C+James+M&rft.aulast=Prasad&rft.aufirst=Sudha&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Rap-GEF/Rap GTPase Signaling Controls Stem Cell Anchoring to their Niche through Regulating DE-Cadherin-Mediated Cell Adhesion in the Drosophila Testis T2 - 47th Annual Drosophila Research Conference AN - 39983947; 4195739 JF - 47th Annual Drosophila Research Conference AU - Zheng, Zhiyu AU - Hong, Wang AU - Singh, Shree Ram AU - Oh, Su-wan AU - Chen, Xiu Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Signal transduction KW - Cell adhesion KW - Guanosinetriphosphatase KW - Testes KW - Stem cells KW - Anchoring KW - Niches KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=A+Rap-GEF%2FRap+GTPase+Signaling+Controls+Stem+Cell+Anchoring+to+their+Niche+through+Regulating+DE-Cadherin-Mediated+Cell+Adhesion+in+the+Drosophila+Testis&rft.au=Zheng%2C+Zhiyu%3BHong%2C+Wang%3BSingh%2C+Shree+Ram%3BOh%2C+Su-wan%3BChen%2C+Xiu&rft.aulast=Zheng&rft.aufirst=Zhiyu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Density Tiling Path and Multiple-Species Expression Arrays T2 - 47th Annual Drosophila Research Conference AN - 39945422; 4195789 JF - 47th Annual Drosophila Research Conference AU - Zhang, Yu AU - Sturgill, David AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=High+Density+Tiling+Path+and+Multiple-Species+Expression+Arrays&rft.au=Zhang%2C+Yu%3BSturgill%2C+David%3BOliver%2C+Brian&rft.aulast=Zhang&rft.aufirst=Yu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Telomeric Retrotransposons may be Stimulated by Terminal Deficiencies in Trans T2 - 47th Annual Drosophila Research Conference AN - 39945419; 4195247 JF - 47th Annual Drosophila Research Conference AU - Frydrychova, Radmila Capkova AU - Archer, Trevor AU - Mason, James Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Retrotransposons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Regulation+of+Cell+Spreading+and+Migration+by+Candidate+Tumor+Suppressor+ING4&rft.au=Shen%2C+Jiang+C%3BKumamoto%2C+Kensuke%3BUnoki%2C+Motoko%3BVarticovski%2C+Lyuba%3BPedeux%2C+Remy%3BHarris%2C+Curtis+C&rft.aulast=Shen&rft.aufirst=Jiang&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Drosophila Homologue of the Human Tumor Suppressor Gene BHD Regulates Male Germline Stem Cell Maintenance and Functions Downstream of Dpp T2 - 47th Annual Drosophila Research Conference AN - 39937191; 4195032 JF - 47th Annual Drosophila Research Conference AU - Singh, Shree R AU - Zen, Wei AU - Zheng, Zhiyu AU - Wang, Hong AU - Oh, Su-Wan AU - Liu, Wei AU - Zbar, Berton AU - Schmidt, Laura S AU - Hou, Steven X Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Tumor suppressor genes KW - Stem cells KW - Tumors KW - Suppressors KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39937191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Drosophila+Homologue+of+the+Human+Tumor+Suppressor+Gene+BHD+Regulates+Male+Germline+Stem+Cell+Maintenance+and+Functions+Downstream+of+Dpp&rft.au=Singh%2C+Shree+R%3BZen%2C+Wei%3BZheng%2C+Zhiyu%3BWang%2C+Hong%3BOh%2C+Su-Wan%3BLiu%2C+Wei%3BZbar%2C+Berton%3BSchmidt%2C+Laura+S%3BHou%2C+Steven+X&rft.aulast=Singh&rft.aufirst=Shree&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dacapo Promotes the Licensing of DNA Replication Origins during Drosophila Endocycles T2 - 47th Annual Drosophila Research Conference AN - 39936154; 4194929 JF - 47th Annual Drosophila Research Conference AU - Lilly, Mary AU - Hong, Amy AU - Narbonne, Karine AU - Fu, Haiquing AU - Aladjem, Mirit Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Licensing KW - Replication origins KW - DNA biosynthesis KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39936154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Dacapo+Promotes+the+Licensing+of+DNA+Replication+Origins+during+Drosophila+Endocycles&rft.au=Lilly%2C+Mary%3BHong%2C+Amy%3BNarbonne%2C+Karine%3BFu%2C+Haiquing%3BAladjem%2C+Mirit&rft.aulast=Lilly&rft.aufirst=Mary&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhodopsin-Mutant Induced Changes in Drosophila Retinal Gene Expression T2 - 47th Annual Drosophila Research Conference AN - 39906090; 4195680 JF - 47th Annual Drosophila Research Conference AU - Padilla, Robert M AU - Li, Moyi AU - Edmundson, Christine AU - Davidson, Florence F Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene expression KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Rhodopsin-Mutant+Induced+Changes+in+Drosophila+Retinal+Gene+Expression&rft.au=Dissanayake%2C+Samudra+K%3BRosenthal%2C+Devin+T%3BHewitt%2C+Kyle+J%3BYang%2C+Sherry%3BWade%2C+Michael%3BTaub%2C+Dennis+D%3BNickoloff%2C+Brian+J%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael%3BRiker%2C+Adam+I%3BWeeraratna%2C+Ashani+T&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Drosophila Tis11 T2 - 47th Annual Drosophila Research Conference AN - 39905970; 4195649 JF - 47th Annual Drosophila Research Conference AU - Fedic, Robert AU - Kennington, Elisabeth A AU - Blackshear, Perry J AU - Mason, James M Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene expression KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Characterization+of+Drosophila+Tis11&rft.au=Fedic%2C+Robert%3BKennington%2C+Elisabeth+A%3BBlackshear%2C+Perry+J%3BMason%2C+James+M&rft.aulast=Fedic&rft.aufirst=Robert&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational Identification of Regulatory Elements in Drosophila Core Promoters: Is there a "Core Promoter Code?". T2 - 47th Annual Drosophila Research Conference AN - 39905499; 4195551 JF - 47th Annual Drosophila Research Conference AU - Sturgill, David AU - FitzGerald, Peter AU - Shyakhtenko, Andrey AU - Oliver, Brian AU - Vinson, Charles Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Promoters KW - Cores KW - Computer applications KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Computational+Identification+of+Regulatory+Elements+in+Drosophila+Core+Promoters%3A+Is+there+a+%22Core+Promoter+Code%3F%22.&rft.au=Sturgill%2C+David%3BFitzGerald%2C+Peter%3BShyakhtenko%2C+Andrey%3BOliver%2C+Brian%3BVinson%2C+Charles&rft.aulast=Sturgill&rft.aufirst=David&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Rac GTPase signaling through the PP5 protein phosphatase. AN - 67810890; 16549782 AB - We have investigated the Rac-dependent mechanism of KCNH2 channel stimulation by thyroid hormone in a rat pituitary cell line, GH(4)C(1), with the patch-clamp technique. Here we present physiological evidence for the protein serine/threonine phosphatase, PP5, as an effector of Rac GTPase signaling. We also propose and test a specific molecular mechanism for PP5 stimulation by Rac-GTP. Inhibition of PP5 with the microbial toxin, okadaic acid, blocked channel stimulation by thyroid hormone and by Rac, but signaling was restored by expression of a toxin-insensitive mutant of PP5, Y451A, which we engineered. PP5 is unique among protein phosphatases in that it contains an N-terminal regulatory domain with three tetratricopeptide repeats (TPR) that inhibit its activity. Expression of the TPR domain coupled to GFP blocked channel stimulation by the thyroid hormone. We also show that the published structures of the PP5 TPR domain and the TPR domain of p67, the Rac-binding subunit of NADPH oxidase, superimpose over 92 alpha carbons. Mutation of the PP5 TPR domain at two predicted contact points with Rac-GTP prevents the TPR domain from functioning as a dominant negative and blocks the ability of Y451A to rescue signaling in the presence of okadaic acid. PP5 stimulation by Rac provides a unique molecular mechanism for the antagonism of Rho-dependent signaling through protein kinases in many cellular processes, including metastasis, immune cell chemotaxis, and neuronal development. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gentile, Saverio AU - Darden, Thomas AU - Erxleben, Christian AU - Romeo, Charles AU - Russo, Angela AU - Martin, Negin AU - Rossie, Sandra AU - Armstrong, David L AD - Environmental Biology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 SP - 5202 EP - 5206 VL - 103 IS - 13 SN - 0027-8424, 0027-8424 KW - ERG1 Potassium Channel KW - 0 KW - Ether-A-Go-Go Potassium Channels KW - KCNH2 protein, human KW - Kcnh2 protein, rat KW - Nuclear Proteins KW - Potassium Channels, Voltage-Gated KW - Thyroid Hormones KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Tyrosine KW - 42HK56048U KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - protein phosphatase 5 KW - rac GTP-Binding Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Thyroid Hormones -- pharmacology KW - Models, Molecular KW - Amino Acid Sequence KW - Electrophysiology KW - Protein Structure, Quaternary KW - Ion Channel Gating -- drug effects KW - Rats KW - Patch-Clamp Techniques KW - Sequence Alignment KW - Molecular Sequence Data KW - Okadaic Acid -- pharmacology KW - Tyrosine -- genetics KW - Tyrosine -- metabolism KW - Potassium Channels, Voltage-Gated -- metabolism KW - Cell Line KW - rac GTP-Binding Proteins -- metabolism KW - rac GTP-Binding Proteins -- chemistry KW - Nuclear Proteins -- genetics KW - Phosphoprotein Phosphatases -- metabolism KW - Phosphoprotein Phosphatases -- genetics KW - Phosphoprotein Phosphatases -- chemistry KW - Nuclear Proteins -- chemistry KW - Nuclear Proteins -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Rac+GTPase+signaling+through+the+PP5+protein+phosphatase.&rft.au=Gentile%2C+Saverio%3BDarden%2C+Thomas%3BErxleben%2C+Christian%3BRomeo%2C+Charles%3BRusso%2C+Angela%3BMartin%2C+Negin%3BRossie%2C+Sandra%3BArmstrong%2C+David+L&rft.aulast=Gentile&rft.aufirst=Saverio&rft.date=2006-03-28&rft.volume=103&rft.issue=13&rft.spage=5202&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-10 N1 - Date created - 2006-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2000 Oct;6(4):899-907 [11090627] Trends Biochem Sci. 2005 Apr;30(4):194-204 [15817396] Brain Res Mol Brain Res. 2001 Jun 20;90(2):101-9 [11406288] EMBO J. 2001 Nov 1;20(21):6028-36 [11689443] J Biol Chem. 2001 Nov 23;276(47):44078-82 [11535607] Trends Cell Biol. 2001 Dec;11(12):471-7 [11719051] Curr Biol. 2002 Jan 8;12(1):27-33 [11790300] Trends Neurosci. 2002 Apr;25(4):191-9 [11998687] Curr Biol. 2002 Aug 6;12(15):1353-8 [12176367] Curr Med Chem. 2002 Nov;9(22):2055-75 [12369870] FEBS Lett. 2003 Jul 3;546(1):93-7 [12829242] Physiol Rev. 2003 Jul;83(3):965-1016 [12843413] Physiol Rev. 2003 Oct;83(4):1325-58 [14506307] Curr Opin Cell Biol. 2003 Oct;15(5):583-9 [14519393] Science. 2003 Nov 14;302(5648):1215-7 [14615541] Trends Biochem Sci. 2003 Dec;28(12):655-62 [14659697] Cell. 2004 Jan 23;116(2):167-79 [14744429] J Cell Mol Med. 2004 Jan-Mar;8(1):22-30 [15090257] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Trends Neurosci. 1992 Oct;15(10):403-8 [1279866] FEBS Lett. 1993 Dec 28;336(3):433-9 [8282106] Biochemistry. 1996 Feb 6;35(5):1606-11 [8634292] J Biol Chem. 1996 Dec 13;271(50):32315-20 [8943293] FEBS Lett. 1997 Jan 2;400(1):136-40 [9000529] J Biol Chem. 1997 Sep 5;272(36):22464-71 [9278397] EMBO J. 1998 Mar 2;17(5):1192-9 [9482716] J Physiol. 1998 Aug 15;511 ( Pt 1):3-14 [9679158] J Biol Chem. 1999 Aug 13;274(33):23666-72 [10438550] J Biol Chem. 1999 Sep 24;274(39):27457-62 [10488078] Genes Dev. 2005 Jan 1;19(1):1-49 [15630019] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5197-201 [16549781] J Biol Chem. 2005 Jan 21;280(3):1790-6 [15546861] EMBO J. 2005 Jan 12;24(1):1-10 [15577939] J Biol Chem. 2005 Feb 11;280(6):4532-43 [15579468] Biochem J. 2005 Mar 1;386(Pt 2):201-14 [15548136] Trends Cell Biol. 2005 Mar;15(3):163-71 [15752980] Trends Endocrinol Metab. 2001 Jan-Feb;12(1):28-32 [11137038] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenously administered vitamin C as cancer therapy: three cases. AN - 67796770; 16567755 AB - Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer. Double-blind placebo-controlled studies of oral vitamin C therapy showed no benefit. Recent evidence shows that oral administration of the maximum tolerated dose of vitamin C (18 g/d) produces peak plasma concentrations of only 220 micromol/L, whereas intravenous administration of the same dose produces plasma concentrations about 25-fold higher. Larger doses (50-100 g) given intravenously may result in plasma concentrations of about 14,000 micromol/L. At concentrations above 1000 micromol/L, vitamin C is toxic to some cancer cells but not to normal cells in vitro. We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy. We examined clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines. Tumour pathology was verified by pathologists at the NCI who were unaware of diagnosis or treatment. In light of recent clinical pharmacokinetic findings and in vitro evidence of anti-tumour mechanisms, these case reports indicate that the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed. JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne AU - Padayatty, Sebastian J AU - Riordan, Hugh D AU - Hewitt, Stephen M AU - Katz, Arie AU - Hoffer, L John AU - Levine, Mark AD - Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md 20892-1372, USA. Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 SP - 937 EP - 942 VL - 174 IS - 7 KW - Vitamins KW - 0 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Abridged Index Medicus KW - Index Medicus KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Kidney Neoplasms -- drug therapy KW - Lymphoma, B-Cell -- drug therapy KW - Ascorbic Acid -- therapeutic use KW - Ascorbic Acid -- administration & dosage KW - Vitamins -- therapeutic use KW - Vitamins -- administration & dosage KW - Urinary Bladder Neoplasms -- drug therapy KW - Carcinoma, Renal Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67796770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.atitle=Intravenously+administered+vitamin+C+as+cancer+therapy%3A+three+cases.&rft.au=Padayatty%2C+Sebastian+J%3BRiordan%2C+Hugh+D%3BHewitt%2C+Stephen+M%3BKatz%2C+Arie%3BHoffer%2C+L+John%3BLevine%2C+Mark&rft.aulast=Padayatty&rft.aufirst=Sebastian&rft.date=2006-03-28&rft.volume=174&rft.issue=7&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.issn=1488-2329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Urol Oncol. 2003 Nov-Dec;21(6):468-74 [14693275] J Urol. 2004 Feb;171(2 Pt 1):561-9 [14713760] Oncologist. 2004;9(1):80-9 [14755017] Integr Cancer Ther. 2003 Jun;2(2):158-9 [15035904] P R Health Sci J. 2004 Jun;23(2):115-8 [15377059] Oncology. 1969;23(1):33-43 [5774953] Chem Biol Interact. 1974 Oct;9(4):285-315 [4430016] Chem Biol Interact. 1975 Nov;11(5):387-93 [1104207] Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9 [1068480] Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42 [279931] N Engl J Med. 1979 Sep 27;301(13):687-90 [384241] Scott Med J. 1979 Apr;24(2):151-3 [227054] Nature. 1980 Apr 17;284(5757):629-31 [7366735] JAMA. 1984 Oct 5;252(13):1684 [6471294] N Engl J Med. 1985 Jan 17;312(3):137-41 [3880867] N Engl J Med. 1985 Jan 17;312(3):178-9 [3965937] J Natl Med Assoc. 2000 Jun;92(6):285-94 [10918764] J Am Coll Nutr. 2000 Aug;19(4):423-5 [10963459] CMAJ. 2001 Feb 6;164(3):351-3 [11232135] CMAJ. 2001 Feb 6;164(3):353-5 [11232136] Br J Cancer. 2001 Jun 1;84(11):1544-50 [11384106] Circulation. 2001 Jun 12;103(23):E117 [11401949] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9842-6 [11504949] Oncology (Williston Park). 2001 Oct;15(10):1267-72; discussion 1272-8, 1283 [11702957] Clin Cancer Res. 2002 Dec;8(12):3658-68 [12473574] Semin Oncol. 2002 Dec;29(6):546-51 [12516037] Semin Oncol. 2002 Dec;29(6):552-62 [12516038] CMAJ. 2003 Jan 21;168(2):180-2 [12538547] Gynecol Oncol. 2003 Mar;88(3):434-9 [12648599] J Am Coll Nutr. 2003 Apr;22(2):118-23 [12672707] BMJ. 2003 Jun 28;326(7404):1453-5 [12829562] Ann N Y Acad Sci. 1987;498:445-54 [3304071] J Urol. 1987 Nov;138(5):1162-3 [3669160] Med Hypotheses. 1991 Nov;36(3):190-4 [1787808] J Urol. 1992 Jun;147(6):1513-5 [1593678] Anticancer Res. 1993 Mar-Apr;13(2):475-80 [8517665] Aust N Z J Med. 1994 Aug;24(4):410-1 [7980244] Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9 [8623000] World J Urol. 1996;14(3):175-81 [8806196] Am J Clin Oncol. 1997 Aug;20(4):416-8 [9256902] JAMA. 1999 Apr 21;281(15):1415-23 [10217058] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9 [16157892] Ann Intern Med. 2004 Apr 6;140(7):533-7 [15068981] Comment In: CMAJ. 2006 Mar 28;174(7):956-7 [16567756] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Immunodominance Rules T2 - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AN - 40003913; 4143131 JF - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AU - Bennink, Jack R Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Immunodominance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.atitle=Immunodominance+Rules&rft.au=Bennink%2C+Jack+R&rft.aulast=Bennink&rft.aufirst=Jack&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=801 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Live Attenuated Pandemic Vaccines T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39906046; 4143208 JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - Subbarao, Kanta Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Vaccines KW - Pandemics KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=Evaluation+of+Live+Attenuated+Pandemic+Vaccines&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PB1-F2: What Does it Do and How Does it Do it? T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39905964; 4143192 DE: JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - Yewdell, Jonathan W Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=PB1-F2%3A+What+Does+it+Do+and+How+Does+it+Do+it%3F&rft.au=Yewdell%2C+Jonathan+W&rft.aulast=Yewdell&rft.aufirst=Jonathan&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigenic Relatedness Among Avian Influenza A H7 Subtype Viruses with Post Infection Mouse Sera T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39802982; 4143189 JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - McAuliffe, Josephine M Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Infection KW - Viruses KW - Fowl plague UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39802982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=Antigenic+Relatedness+Among+Avian+Influenza+A+H7+Subtype+Viruses+with+Post+Infection+Mouse+Sera&rft.au=McAuliffe%2C+Josephine+M&rft.aulast=McAuliffe&rft.aufirst=Josephine&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toll-Like Receptor Ligands Influence the Magnitude and Quality of HIV Specific Immune Responses in Non-Human Primates T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 40008792; 4150868 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Seder, Robert A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Toll-like receptors KW - Ligands KW - Human immunodeficiency virus KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Toll-Like+Receptor+Ligands+Influence+the+Magnitude+and+Quality+of+HIV+Specific+Immune+Responses+in+Non-Human+Primates&rft.au=Seder%2C+Robert+A&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circumventing CD4 Deficiency to Induce Long-Lived Memory CTL T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39956046; 4150917 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Berzofsky, Jay A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Memory cells KW - Cytotoxicity KW - Lymphocytes T KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Circumventing+CD4+Deficiency+to+Induce+Long-Lived+Memory+CTL&rft.au=Berzofsky%2C+Jay+A&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunization with Vaccinia Virus Induces Polyfunctional T Cell Responses T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39955999; 4150901 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Precopio, Melissa L Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Immunization KW - Lymphocytes T KW - Vaccinia virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Immunization+with+Vaccinia+Virus+Induces+Polyfunctional+T+Cell+Responses&rft.au=Precopio%2C+Melissa+L&rft.aulast=Precopio&rft.aufirst=Melissa&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Regulatory T Cell Markers and Indoleamine 2,3 Dioxygenase in Spleen and Gut of SIV-Infected Macaques T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39951782; 4150887 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Boasso, Adriano Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Digestive tract KW - Lymphocytes T KW - Immunoregulation KW - Dioxygenase KW - Spleen KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39951782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Increased+Regulatory+T+Cell+Markers+and+Indoleamine+2%2C3+Dioxygenase+in+Spleen+and+Gut+of+SIV-Infected+Macaques&rft.au=Boasso%2C+Adriano&rft.aulast=Boasso&rft.aufirst=Adriano&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Immunity Following Systemic SIV DNA Priming/Mucosal Replication-Competent Ad-SIV Boosting of Rhesus Macaques is Enhanced by Cytokine DNAs and Includes Potent Mucosal CD8+T Cell Memory Responses T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39922193; 4150918 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Robert-Guroff, Marjorie Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Cytokines KW - Immunological memory KW - Immunity (cell-mediated) KW - Immunity KW - Simian immunodeficiency virus KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Cellular+Immunity+Following+Systemic+SIV+DNA+Priming%2FMucosal+Replication-Competent+Ad-SIV+Boosting+of+Rhesus+Macaques+is+Enhanced+by+Cytokine+DNAs+and+Includes+Potent+Mucosal+CD8%2BT+Cell+Memory+Responses&rft.au=Robert-Guroff%2C+Marjorie&rft.aulast=Robert-Guroff&rft.aufirst=Marjorie&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenicity and Protective Efficacy of Prime/Boost Vaccine Regimens Based on Replication-Competent Ad Recombinants Encoding HIVtat, HIVenv, SIVgag, and SIVnef in a Rhesus Macaque SHIV89.6P Challenge Model T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39921748; 4150894 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Demberg, Thorsten Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Vaccines KW - Immunogenicity KW - Models KW - Recombinants KW - Disease control KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Immunogenicity+and+Protective+Efficacy+of+Prime%2FBoost+Vaccine+Regimens+Based+on+Replication-Competent+Ad+Recombinants+Encoding+HIVtat%2C+HIVenv%2C+SIVgag%2C+and+SIVnef+in+a+Rhesus+Macaque+SHIV89.6P+Challenge+Model&rft.au=Demberg%2C+Thorsten&rft.aulast=Demberg&rft.aufirst=Thorsten&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Envelope Glycoprotein Structural Analysis for Improved Immunogen Design T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39916156; 4150879 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Wyatt, Richard T Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Structural analysis KW - Envelopes KW - Glycoproteins KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39916156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=HIV-1+Envelope+Glycoprotein+Structural+Analysis+for+Improved+Immunogen+Design&rft.au=Wyatt%2C+Richard+T&rft.aulast=Wyatt&rft.aufirst=Richard&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DC-SIGN Capture of HIV gp120 Relies on Avidity Effects, and is Altered by CD4 Ligation T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39914863; 4150869 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Van Ryk, Donald I Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Avidity KW - CD4 antigen KW - Glycoprotein gp120 KW - DC-SIGN protein KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39914863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=DC-SIGN+Capture+of+HIV+gp120+Relies+on+Avidity+Effects%2C+and+is+Altered+by+CD4+Ligation&rft.au=Van+Ryk%2C+Donald+I&rft.aulast=Van+Ryk&rft.aufirst=Donald&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39906235; 4143279 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Price, David A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Vaccines KW - CD8 antigen KW - Antigen presentation KW - Major histocompatibility complex KW - Antigens KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Functional+Consequences+of+Peptide-Major+Histocompatibility+Complex+Class+I+Antigen+Presentation+in+the+Context+of+Enhanced+CD8+Coreceptor+Binding%3A+Implications+for+Vaccine+Delivery&rft.au=Price%2C+David+A&rft.aulast=Price&rft.aufirst=David&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stem Cell Renewal and Regeneration in the CNS T2 - 2006 Keystone Symposia on Stem Cells (G4) AN - 39901442; 4142045 JF - 2006 Keystone Symposia on Stem Cells (G4) AU - McKay, Ronald D Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Central nervous system KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Stem+Cells+%28G4%29&rft.atitle=Stem+Cell+Renewal+and+Regeneration+in+the+CNS&rft.au=McKay%2C+Ronald+D&rft.aulast=McKay&rft.aufirst=Ronald&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Stem+Cells+%28G4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Antigen Designs for Env Responses T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39895609; 4143271 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Nabel, Gary J Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=New+Antigen+Designs+for+Env+Responses&rft.au=Nabel%2C+Gary+J&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recombination and Complementation: Two Modes of Interactions Among HIVs T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39895576; 4143255 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Hu, Wei-Shau Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Recombination KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Recombination+and+Complementation%3A+Two+Modes+of+Interactions+Among+HIVs&rft.au=Hu%2C+Wei-Shau&rft.aulast=Hu&rft.aufirst=Wei-Shau&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39893355; 4143294 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Brenchley, Jason M Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antiretroviral agents KW - Infection KW - Lymphocytes T KW - Antiretroviral therapy KW - CD4 antigen KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Continued+Infection+of+Mucosal+CD4%2B+T+Cells+is+Associated+with+Mucosal+Depletion+Despite+Years+of+Antiretroviral+Therapy&rft.au=Brenchley%2C+Jason+M&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39893014; 4143285 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Duvall, Melody G Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Infection KW - Lymphocytes T KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Profiling+Distinguishes+Astrocytomas+of+Different+Grades+and+Identifies+Differential+Tumor+Markers&rft.au=Li%2C+Jie%3BWeil%2C+Robert%3BOkamoto%2C+Hiroaki%3BVortmeyer%2C+Alexander%3BLubensky%2C+Irina%3BPark%2C+Deric%3BFuruta%2C+Makoto%3BLee%2C+Youn-Soo%3BZeng%2C+Weifen%3BOldfield%2C+Edward+H%3BZhuang%2C+Zhengping&rft.aulast=Li&rft.aufirst=Jie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39892954; 4143261 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Strebel, Klaus Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Infectivity KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Degradation+of+APOBEC3G+and+Rescue+of+Viral+Infectivity+are+Separable+Activities+of+HIV-1+Vif&rft.au=Strebel%2C+Klaus&rft.aulast=Strebel&rft.aufirst=Klaus&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on VRC Clinical Trials T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39880736; 4150903 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Graham, Barney S Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Imprinted+Adaptor+Protein+Grb10+Interacts+Genetically+with+Nf1%2Fp53+in+Development+and+Tumorigenesis&rft.au=Reilly%2C+Karlyne+M%3BTuskan%2C+Robert%3BKumar%2C+Krishan%3BStewart%2C+Colin%3BHagan%2C+John%3BFox%2C+Kristi&rft.aulast=Reilly&rft.aufirst=Karlyne&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of the Neutralizing Specificity in Complex Polyclonal Sera T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39879070; 4150921 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Li, Yuxing Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Analysis+of+the+Neutralizing+Specificity+in+Complex+Polyclonal+Sera&rft.au=Li%2C+Yuxing&rft.aulast=Li&rft.aufirst=Yuxing&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of CD4+ T Cells in the Maintenance of SIV-Specific CD8+ T Memory Cells and their Role in Protection from SIVmac251 T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39864407; 4150900 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Franchini, Genoveffa Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Memory cells KW - CD8 antigen KW - Lymphocytes T KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39864407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Importance+of+CD4%2B+T+Cells+in+the+Maintenance+of+SIV-Specific+CD8%2B+T+Memory+Cells+and+their+Role+in+Protection+from+SIVmac251&rft.au=Franchini%2C+Genoveffa&rft.aulast=Franchini&rft.aufirst=Genoveffa&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6 T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39840571; 4143262 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Lee, Kyeongeun Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Target cells KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=HIV-1+Cell+Killing+Blocked+by+Pre-mRNA+Factor+CPSF6&rft.au=Lee%2C+Kyeongeun&rft.aulast=Lee&rft.aufirst=Kyeongeun&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CTLA4 Blockade in Antiretroviral Therapy-Treated SIVmac251-Infected Macaques Does Not Augment Global T Cell Activation and Viral Replication T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39789678; 4150911 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Vaccari, Monica Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antiretroviral agents KW - Replication KW - CTLA-4 protein KW - Lymphocytes T KW - Cell activation KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39789678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=CTLA4+Blockade+in+Antiretroviral+Therapy-Treated+SIVmac251-Infected+Macaques+Does+Not+Augment+Global+T+Cell+Activation+and+Viral+Replication&rft.au=Vaccari%2C+Monica&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pseudorotational Cycle as a Tool for Drug Design and Discovery T2 - 231st National Meeting of the American Chemical Society AN - 40129966; 4118547 JF - 231st National Meeting of the American Chemical Society AU - Marquez, Victor E Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Drug development KW - Drug discovery KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=The+Pseudorotational+Cycle+as+a+Tool+for+Drug+Design+and+Discovery&rft.au=Marquez%2C+Victor+E&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products as Inhibitors and Mechanistic Probes in Infectious Diseases T2 - 231st National Meeting of the American Chemical Society AN - 40103080; 4118369 JF - 231st National Meeting of the American Chemical Society AU - Bewley, Carole A Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - infectious diseases KW - Inhibitors KW - Probes KW - natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40103080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Marine+Natural+Products+as+Inhibitors+and+Mechanistic+Probes+in+Infectious+Diseases&rft.au=Bewley%2C+Carole+A&rft.aulast=Bewley&rft.aufirst=Carole&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery? T2 - 231st National Meeting of the American Chemical Society AN - 40061651; 4118367 JF - 231st National Meeting of the American Chemical Society AU - Newman, David J Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Drug discovery KW - natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40061651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Natural+Products+as+Leads+to+Potential+Drugs%3A+An+Old+Process+or+the+New+Hope+for+Drug+Discovery%3F&rft.au=Newman%2C+David+J&rft.aulast=Silva&rft.aufirst=Aloisio&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Symbiotic relationship of pharmacogenetics and drugs of abuse. AN - 67828507; 16584126 AB - Pharmacogenetics/pharmacogenomics is the study of how genetic variation affects pharmacology, the use of drugs to treat disease. When drug responses are predicted in advance, it is easier to tailor medications to different diseases and individuals. Pharmacogenetics provides the tools required to identify genetic predictors of probable drug response, drug efficacy, and drug-induced adverse events-identifications that would ideally precede treatment decisions. Drug abuse and addiction genetic data have advanced the field of pharmacogenetics in general. Although major findings have emerged, pharmacotherapy remains hindered by issues such as adverse events, time lag to drug efficacy, and heterogeneity of the disorders being treated. The sequencing of the human genome and high-throughput technologies are enabling pharmacogenetics to have greater influence on treatment approaches. This review highlights key studies and identifies important genes in drug abuse pharmacogenetics that provide a basis for better diagnosis and treatment of drug abuse disorders. JF - The AAPS journal AU - Rutter, Joni L AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Boulevard, Bethesda, MD 20892, USA. jrutter@mail.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - E174 EP - E184 VL - 8 IS - 1 KW - Street Drugs KW - 0 KW - Index Medicus KW - Humans KW - Genetic Variation -- genetics KW - Pharmacogenetics -- methods KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Symbiotic+relationship+of+pharmacogenetics+and+drugs+of+abuse.&rft.au=Rutter%2C+Joni+L&rft.aulast=Rutter&rft.aufirst=Joni&rft.date=2006-03-24&rft.volume=8&rft.issue=1&rft.spage=E174&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 2005 Jun;81(2):381-6 [15925402] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] J Med Genet. 2005 Jul;42(7):583-7 [15994880] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] J Neurochem. 2005 Jul;94(2):352-9 [15998286] Pharmacogenomics J. 2005;5(4):218-20 [16041391] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12938-43 [16118273] J Biol Chem. 2005 Sep 23;280(38):32618-24 [16046395] PLoS Med. 2005 Sep;2(9):e266; 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author reply 1445-7 [15178784] Arch Gen Psychiatry. 2004 Jun;61(6):597-606 [15184239] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Arch Gen Psychiatry. 1998 Nov;55(11):973-9 [9819065] J Am Med Inform Assoc. 2005 Mar-Apr;12(2):121-9 [15561790] J Pain. 2005 Mar;6(3):159-67 [15772909] Pharmacogenomics J. 2005;5(2):89-95 [15772696] Am J Hum Genet. 2005 May;76(5):859-64 [15759211] Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):5-9 [15729709] Trends Pharmacol Sci. 2005 Jun;26(6):311-7 [15925706] Neuropsychopharmacology. 2005 Jul;30(7):1374-82 [15827573] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhancement of functional antibody responses to AMA1- C1/Alhydrogel super([registered]), a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide AN - 17070564; 6698522 AB - Apical membrane antigen 1 (AMA1) has been shown to be a promising malaria vaccine candidate. The multiallelic AMA1-C1 vaccine currently in Phase 1 trials in the US and Mali contains an equal mixture of the ectodomain portion of recombinant AMA1 from the FVO and 3D7 clones of Plasmodium falciparum, formulated on Alhydrogel. It is hoped that inclusion of a human-optimized CpG oligodeoxynucleotide (ODN) (CPG 7909) with our existing AMA1-C1/Alhydrogel vaccine will lead to a higher concentration of functional AMA1-C1 antibodies. Preclinical studies were performed in mice, rats and guinea pigs to assess the safety, immunogenicity and functionality of the immune response to AMA1-C1 with Alhydrogel + CPG 7909 compared to antigen with Alhydrogel alone. Day 42 mean anti-AMA1 ELISA titer values derived from individual animals were compared between Alhydrogel and Alhydrogel + CPG 7909 groups at each antigen dose for each species. Sera from Alhydrogel + CPG 7909 groups displayed significantly higher antibody titers (P - 0.025) than their comparable Alhydrogel alone group. Mouse IgG isotype analysis showed that AMA1-C1/Alhydrogel induced a predominately Th2 type response while AMA1-C1/Alhydrogel + CPG 7909 gave a mixed Th1/Th2 type response. When tested for functional activity by in vitro inhibition of parasite invasion, IgG isolated from serum pools of AMA1- C1/Alhydrogel + CPG 7909 animals was more effective against both FVO and 3D7 parasites than an equal concentration of IgG from animals receiving vaccines adjuvanted with Alhydrogel alone. These promising preclinical results have recently led to the start of a Phase 1 trial in the US. JF - Vaccine AU - Mullen, Gregory ED AU - Giersing, Birgitte K AU - Ajose-Popoola, Olubunmi AU - Davis, Heather L AU - Kothe, Cheryl AU - Zhou, Hong AU - Aebig, Joan AU - Dobrescu, Gelu AU - Saul, Allan AU - Long, Carole A AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, gmullen@niaid.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2497 EP - 2505 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Apical membrane antigen 1 KW - Parasites KW - Helper cells KW - Malaria KW - Oligonucleotides KW - Lymphocytes T KW - Enzyme-linked immunosorbent assay KW - CpG islands KW - Plasmodium falciparum KW - Immunogenicity KW - Immunoglobulin G KW - Immune response KW - Vaccines KW - K 03086:Immunology & vaccination KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17070564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhancement+of+functional+antibody+responses+to+AMA1-+C1%2FAlhydrogel+super%28%5Bregistered%5D%29%2C+a+Plasmodium+falciparum+malaria+vaccine%2C+with+CpG+oligodeoxynucleotide&rft.au=Mullen%2C+Gregory+ED%3BGiersing%2C+Birgitte+K%3BAjose-Popoola%2C+Olubunmi%3BDavis%2C+Heather+L%3BKothe%2C+Cheryl%3BZhou%2C+Hong%3BAebig%2C+Joan%3BDobrescu%2C+Gelu%3BSaul%2C+Allan%3BLong%2C+Carole+A&rft.aulast=Mullen&rft.aufirst=Gregory&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2497&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.12.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Plasmodium falciparum; CpG islands; Vaccines; Helper cells; Immunoglobulin G; Lymphocytes T; Oligonucleotides; Parasites; Malaria; Apical membrane antigen 1; Immunogenicity; Enzyme-linked immunosorbent assay; Immune response DO - http://dx.doi.org/10.1016/j.vaccine.2005.12.034 ER - TY - JOUR T1 - Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates AN - 17068488; 6698543 AB - The P/C gene of human parainfluenza virus type 1 (HPIV1) encodes a nested set of related accessory C proteins, C'/C/Y1/Y2, which have been shown in other paramyxoviruses to have a role in evasion of the type I interferon (IFN) response following virus infection. We previously demonstrated that a set of two amino acid substitutions, C super(R84G)/HN super(T553A), and a separate amino acid substitution, C super(F170S), are independently attenuating for HPIV1 in African green monkeys (AGMs). However, in each case the attenuation (att) phenotype is vulnerable to reversion by a single nucleotide change back to wild type. Using reverse genetics, recombinant HPIV1 (rHPIV1) vaccine candidates were generated that were designed for increased genetic and phenotypic stability by: (i) creating a two-amino acid deletion and substitution at the site of the C super(F170S) mutation, yielding C super( Delta 170); (ii) introducing a six amino acid deletion in the N-terminal region of C, C super( Delta 10-15); and (iii) combining these stable deletion mutations with the att C super(R84G)/HN super(T553A) mutation. The resulting rHPIV1 vaccine candidates were evaluated for attenuation in hamsters and AGMs and for immunogenicity and protective efficacy in AGMs. The C super( Delta 10- 15) mutation was attenuating in hamsters but not in AGMs, and likely will be of limited value for an HPIV1 vaccine. Conversely, the C super(R84G)/HN super(T553A) mutation set was attenuating in AGMs but not in hamsters. Thus, these two mutations demonstrated reciprocal host range phenotypes involving different regions of C. The C super( Delta 170) mutation conferred a significant level of attenuation in hamsters and AGMs that closely resembled that of C super(F170S) and will be of particular utility for vaccine development because it involves a deletion of six nucleotides rendering it highly refractory to reversion. The combination of the C super(R84G)/HN super(T553A) mutation set and the C super( Delta 170) deletion mutation yielded a virus, rC super(R84G/ Delta 170)HN super(T553A), that exhibited a satisfactory level of attenuation in hamsters and AGMs and was immunogenic and highly protective against HPIV1 wt challenge. This virus will be evaluated clinically as a live intranasal HPIV1 vaccine, one that can be further attenuated as necessary by the introduction of additional stabilized att mutations previously developed in the L protein. JF - Vaccine AU - Bartlett, Emmalene J AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Collins, Peter L AU - Murphy, Brian R AU - Skiadopoulos, Mario H AD - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bldg 50, Room 6511, 50 South Drive MSC 8007; Bethesda, MD 20892-8007, USA, EBartlett@niaid.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2674 EP - 2684 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Human parainfluenza virus KW - Attenuating mutations KW - Interferon antagonist KW - Vaccine candidates KW - Non-human primate study KW - double prime L protein KW - Host range KW - Amino acid substitution KW - Reversion KW - double prime C gene KW - Infection KW - Nucleotides KW - Parainfluenza virus KW - Parainfluenza KW - Interferon KW - Gene deletion KW - Immunogenicity KW - double prime C protein KW - Vaccines KW - Mutation KW - W3 33365:Vaccines (other) KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17068488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Introducing+point+and+deletion+mutations+into+the+P%2FC+gene+of+human+parainfluenza+virus+type+1+%28HPIV1%29+by+reverse+genetics+generates+attenuated+and+efficacious+vaccine+candidates&rft.au=Bartlett%2C+Emmalene+J%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSkiadopoulos%2C+Mario+H&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2674&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.10.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - double prime L protein; Amino acid substitution; Host range; Reversion; Infection; double prime C gene; Nucleotides; Parainfluenza; Interferon; Gene deletion; Immunogenicity; double prime C protein; Vaccines; Mutation; Parainfluenza virus DO - http://dx.doi.org/10.1016/j.vaccine.2005.10.047 ER - TY - JOUR T1 - Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. AN - 67756196; 16539384 AB - This paper examines two biological models of anticancer activity, cytotoxicity and hollow fiber (HF) activity, for chemotherapeutic agents evaluated as part of the National Cancer Institute's (NCI's) drug screening effort. Our analysis proposes strategies to globally assess compounds tested in the NCI's 60-cell (NCI60) in vitro anticancer screen in terms of structural features, biological activity, target specificity, and mechanism of action by data integration via our self-organizing maps of structural and biological response patterns. We have built statistical models to predict compound potency and HF activity based on physicochemical properties. Our results find that it is the combination of different structural properties that determines a compound's biological activity. A direct correlation is also found between compound potency and specificity, indicating that specific targeting, rather than promiscuous poisoning, gives rise to potency. Finally, we offer a strategy to exploit this relationship for future mining of novel anticancer candidates. JF - Journal of medicinal chemistry AU - Huang, Ruili AU - Wallqvist, Anders AU - Covell, David G AD - Developmental Therapeutics Program, Screening Technologies Branch, Laboratory of Computational Technologies, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA. Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 SP - 1964 EP - 1979 VL - 49 IS - 6 SN - 0022-2623, 0022-2623 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - United States KW - National Institutes of Health (U.S.) KW - Databases, Factual KW - Drug Screening Assays, Antitumor KW - Quantitative Structure-Activity Relationship KW - Models, Statistical KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67756196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Assessment+of+in+vitro+and+in+vivo+activities+in+the+National+Cancer+Institute%27s+anticancer+screen+with+respect+to+chemical+structure%2C+target+specificity%2C+and+mechanism+of+action.&rft.au=Huang%2C+Ruili%3BWallqvist%2C+Anders%3BCovell%2C+David+G&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2006-03-23&rft.volume=49&rft.issue=6&rft.spage=1964&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Roles of NF-kappaB in Control of Autoimmunity T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 40006123; 4141937 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Siebenlist, Ulrich K Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Roles+of+NF-kappaB+in+Control+of+Autoimmunity&rft.au=Siebenlist%2C+Ulrich+K&rft.aulast=Siebenlist&rft.aufirst=Ulrich&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Becoming an NCI-Approved Clinical Investigator T2 - 59th Annual Cancer Symposium of the Society of Surgical Oncology (SSO 2006) AN - 39982595; 4195897 DE: JF - 59th Annual Cancer Symposium of the Society of Surgical Oncology (SSO 2006) AU - Mooney, Margaret M Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39982595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Cancer+Symposium+of+the+Society+of+Surgical+Oncology+%28SSO+2006%29&rft.atitle=Becoming+an+NCI-Approved+Clinical+Investigator&rft.au=Mooney%2C+Margaret+M&rft.aulast=Mooney&rft.aufirst=Margaret&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Cancer+Symposium+of+the+Society+of+Surgical+Oncology+%28SSO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.surgonc.org/pdf/SSO_06_Prelim_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor Receptor 3 Related Craniosynostosis (Muenke Syndrome): A Further Description of Phenotype T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39946230; 4150599 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Doherty, Emily AU - Lacbawan, Felicitas AU - Rosenbaum, Kenneth AU - Hadley, Donald AU - Domingo, Demetrio AU - Hart, Thomas AU - Brewer, Carmen AU - Zalewski, Christopher AU - Kim, H AU - Solomon, Beth AU - Glass, Penny AU - Brooks, Brian AU - Immken, LaDonna AU - Kimonis, Virginia AU - Knightly, Carol AU - McDonald-McGinn, Donna AU - Zackai, Elaine AU - Muenke, Maximilian Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Craniosynostosis KW - Fibroblast growth factor receptor 3 KW - Phenotypes KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Fibroblast+Growth+Factor+Receptor+3+Related+Craniosynostosis+%28Muenke+Syndrome%29%3A+A+Further+Description+of+Phenotype&rft.au=Doherty%2C+Emily%3BLacbawan%2C+Felicitas%3BRosenbaum%2C+Kenneth%3BHadley%2C+Donald%3BDomingo%2C+Demetrio%3BHart%2C+Thomas%3BBrewer%2C+Carmen%3BZalewski%2C+Christopher%3BKim%2C+H%3BSolomon%2C+Beth%3BGlass%2C+Penny%3BBrooks%2C+Brian%3BImmken%2C+LaDonna%3BKimonis%2C+Virginia%3BKnightly%2C+Carol%3BMcDonald-McGinn%2C+Donna%3BZackai%2C+Elaine%3BMuenke%2C+Maximilian&rft.aulast=Doherty&rft.aufirst=Emily&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self-Assembly of the Influenza Hemagglutinin in the Plasma Membrane T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39935635; 4141908 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Zimmerberg, Joshua Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Plasma membranes KW - Self-assembly KW - Hemagglutinins KW - Influenza UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=Self-Assembly+of+the+Influenza+Hemagglutinin+in+the+Plasma+Membrane&rft.au=Zimmerberg%2C+Joshua&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Glycine Substitutions in the Amino end of Type I Collagen by Biochemical Screening of Fibroblast Collagen Requires Supplementation by Direct Sequencing for Osteogenesis Imperfecta Probands T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39914914; 4150538 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Cabral, Wayne AU - Milgrom, Sarah AU - Letocha, Anne AU - Moriarty, Emily AU - Marini, Joan Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Fibroblasts KW - Glycine KW - Collagen (type I) KW - Supplementation KW - Osteogenesis imperfecta KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39914914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Novel+Functional+Group+of+Thalidomide+Analogues+Selectively+Kill+Leukemic+Cells&rft.au=Ge%2C+Yun%3BMontano%2C+Idalia%3BFreebern%2C+Wendy+J%3BHaggerty%2C+Cynthia+M%3BCui%2C+Wenwu%3BPonciano-Jackson%2C+Damaris%3BChandramouli%2C+G+V+R%3BLepper%2C+Erin%3BFigg%2C+William+D%3BJackson%2C+Sharon+H%3BGardner%2C+Kevin&rft.aulast=Ge&rft.aufirst=Yun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Antigen-Induced Association of the B Cell Receptor with Lipid Rafts Visualized in Living Cells by FRET T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39897381; 4141896 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Pierce, Susan K Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Lipid rafts KW - Lymphocytes B KW - Fluorescence resonance energy transfer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=The+Antigen-Induced+Association+of+the+B+Cell+Receptor+with+Lipid+Rafts+Visualized+in+Living+Cells+by+FRET&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consortium for Osteogenesis Imperfecta Mutations: Lethal Regions in the Helical Portion of Type I Collagen Chains Align with Collagen Binding Sites for Integrin and Proteoglycans T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39875098; 4150756 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Marini, Joan AU - Forlino, Antonella AU - Cabral, Wayne AU - Barnes, Aileen AU - San Antonio, James AU - Milgrom, Sarah AU - Hyland, James AU - Korkko, Jarmo AU - Prockop, Darwin AU - DePaepe, Anne AU - Coucke, Paul AU - Glorieux, Francis AU - Roughley, Peter AU - Lund, Allan AU - Kuurila, Kaija AU - Cohn, Dan AU - Krakow, Deborah AU - Mottes, Monica AU - Dalgleish, Raymond AU - Byers, Peter Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Mutation KW - Collagen (type I) KW - Osteogenesis imperfecta KW - Proteoglycans KW - Integrins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Consortium+for+Osteogenesis+Imperfecta+Mutations%3A+Lethal+Regions+in+the+Helical+Portion+of+Type+I+Collagen+Chains+Align+with+Collagen+Binding+Sites+for+Integrin+and+Proteoglycans&rft.au=Marini%2C+Joan%3BForlino%2C+Antonella%3BCabral%2C+Wayne%3BBarnes%2C+Aileen%3BSan+Antonio%2C+James%3BMilgrom%2C+Sarah%3BHyland%2C+James%3BKorkko%2C+Jarmo%3BProckop%2C+Darwin%3BDePaepe%2C+Anne%3BCoucke%2C+Paul%3BGlorieux%2C+Francis%3BRoughley%2C+Peter%3BLund%2C+Allan%3BKuurila%2C+Kaija%3BCohn%2C+Dan%3BKrakow%2C+Deborah%3BMottes%2C+Monica%3BDalgleish%2C+Raymond%3BByers%2C+Peter&rft.aulast=Marini&rft.aufirst=Joan&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Breakpoint-Phenotype Analysis and Stereophotogrammetry of Chromosome 2q37 Deletion Syndrome T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39874470; 4150612 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Lacbawan, Felicitas AU - Domingo, Demetrio AU - Jones, Marypat AU - Hart, Thomas AU - Chandrasekharappa, Settara AU - Doherty, Emily Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Chromosome deletion KW - Chromosome 2 KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Molecular+Breakpoint-Phenotype+Analysis+and+Stereophotogrammetry+of+Chromosome+2q37+Deletion+Syndrome&rft.au=Lacbawan%2C+Felicitas%3BDomingo%2C+Demetrio%3BJones%2C+Marypat%3BHart%2C+Thomas%3BChandrasekharappa%2C+Settara%3BDoherty%2C+Emily&rft.aulast=Lacbawan&rft.aufirst=Felicitas&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The National Ophthalmic Disease Genotyping Network (EyeGENE) T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39869971; 4150779 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Smaoui, Nizar AU - Tumminia, Santa AU - Blain, Delphine AU - Chin, Hemin AU - Sieving, Paul AU - Brooks, Brian Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Genotyping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=The+National+Ophthalmic+Disease+Genotyping+Network+%28EyeGENE%29&rft.au=Smaoui%2C+Nizar%3BTumminia%2C+Santa%3BBlain%2C+Delphine%3BChin%2C+Hemin%3BSieving%2C+Paul%3BBrooks%2C+Brian&rft.aulast=Smaoui&rft.aufirst=Nizar&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Disruption of the Deubiquitinating Enzyme CYLD Causes Heightened Mucosal Inflammation and Tumorigenesis T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39853454; 4141916 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Zhang, Jun Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Enzymes KW - Tumorigenesis KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39853454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Genetic+Disruption+of+the+Deubiquitinating+Enzyme+CYLD+Causes+Heightened+Mucosal+Inflammation+and+Tumorigenesis&rft.au=Zhang%2C+Jun&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Lipid Microdomains in HIV-1 Replication T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39853375; 4141907 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Freed, Eric O Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Lipid rafts KW - Replication KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39853375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=Role+of+Lipid+Microdomains+in+HIV-1+Replication&rft.au=Freed%2C+Eric+O&rft.aulast=Freed&rft.aufirst=Eric&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and TP53 Status T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39842478; 4141934 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Chen, Zhong Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - P53 protein KW - Squamous cell carcinoma KW - Head and neck cancer KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Molecular+Profiling+Distinguishes+Head+and+Neck+Squamous+Cell+Carcinomas+Expressing+Novel+Gene+Signatures+Related+to+NF-kappaB+and+TP53+Status&rft.au=Chen%2C+Zhong&rft.aulast=Chen&rft.aufirst=Zhong&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39839402; 4141947 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Van Waes, Carter Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Squamous cell carcinoma KW - P53 protein KW - Proteasomes KW - Head and neck cancer KW - IKK protein KW - Tumors KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=The+Proteasome%2C+IKK%2C+and+p53+in+Activation+of+NF-kappaB+and+Therapy+of+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Van+Waes%2C+Carter&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39783608; 4141963 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Staudt, Louis M Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Cancer KW - RNA-mediated interference KW - Genetic screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39783608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Genetic+Screens+with+an+RNA+Interference+Library+to+Identify+New+Molecular+Targets+in+Cancer&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction between Secretory Leukocyte Protease Inhibitor (SLPI) and Granulin-Epithelin Precursor (prgn) is Necessary for Proliferation and Survival in Ovarian Cancer T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 40025523; 4196366 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Simpkins, Fiona AU - Kamrava, Mitchell AU - Devoogdt, Nick AU - Tchabo, Nana AU - Alejandro, Emilyn AU - Kohn, Elise C Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovarian cancer KW - Proteinase inhibitors KW - Leukocytes KW - Cell survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40025523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=HIV+Protease+Inhibitors+as+Cancer+Therapeutics%3A+Is+Off-The-Shelf+Right+on+Target%3F&rft.au=Gills%2C+Joell+J%3BLopiccolo%2C+Jaclyn%3BAbu-Asab%2C+Mones+S%3BShoemaker%2C+Robert%3BBorojerdi%2C+Jennifer%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profiling of Mucinous Tumors of the Ovary Identifies Genes of Clinicopathologic Importance T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 40020837; 4196286 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Wamunyokoli, Fred W AU - Bonome, Tomas AU - Lee, Ji-Young AU - Feltmate, Colleen M AU - Welch, William R AU - Radonovich, Mike AU - Pise-Masison, Cindy AU - Brady, John AU - Hao, Ke AU - Berkowitz, Ross S AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovaries KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Network+Profiling+of+Multiple+Myeloma+Bone+Marrow+Aspirates+Using+Reverse+Phase+Protein+Microarrays&rft.au=Sheehan%2C+Katherine+M%3BBurington%2C+Bart%3BRasmussen%2C+Erik%3BCrowley%2C+John%3BHuang%2C+Yongsheng%3BTricot%2C+Guido%3BBarlogie%2C+Bart%3BShaughnessy+Jr%2C+John+D%3BGulmann%2C+Christian%3BKay%2C+Elaine+W%3BWulfkuhle%2C+Julia+D%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Sheehan&rft.aufirst=Katherine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Gene Expression Signature able to Predict for Survival in Patients with High-Grade Late-Stage Serous Ovarian Cancer: Identification of a Prognostic Gene Implicated in Angiogenesis T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 39952238; 4196084 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Bonome, Tomas AU - Park, Dong-Choon AU - Hao, Ke AU - Donninger, Howard AU - Bell, Aaron AU - Brady, John AU - Radonovich, Mike AU - Barrett, J Carl AU - Koon, Colin E AU - Wong, Wing H AU - Lee, Ji-Young AU - Welch, William R AU - Berkowitz, Ross S AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovarian cancer KW - Angiogenesis KW - Survival KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+on+Women%27s+Cancer%40%40uTM%40&rft.atitle=Characterization+of+a+Gene+Expression+Signature+able+to+Predict+for+Survival+in+Patients+with+High-Grade+Late-Stage+Serous+Ovarian+Cancer%3A+Identification+of+a+Prognostic+Gene+Implicated+in+Angiogenesis&rft.au=Bonome%2C+Tomas%3BPark%2C+Dong-Choon%3BHao%2C+Ke%3BDonninger%2C+Howard%3BBell%2C+Aaron%3BBrady%2C+John%3BRadonovich%2C+Mike%3BBarrett%2C+J+Carl%3BKoon%2C+Colin+E%3BWong%2C+Wing+H%3BLee%2C+Ji-Young%3BWelch%2C+William+R%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Bonome&rft.aufirst=Tomas&rft.date=2006-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+on+Women%27s+Cancer%40%40uTM%40&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. AN - 67773734; 16537416 AB - Free radical formation has been investigated in diverse experimental models of LPS-induced inflammation. Here, using electron spin resonance (ESR) and the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone, we have detected an ESR spectrum of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in the lipid extract of mouse skin treated with LPS for 6 h. The ESR spectrum was consistent with the trapping of lipid-derived radical adducts. In addition, a secondary radical-trapping technique using dimethyl sulfoxide (DMSO) demonstrated methyl radical formation, revealing the production of hydroxyl radical. Radical adduct formation was suppressed by aminoguanidine, N-(3-aminomethyl)benzylacetamidine (1400W), or allopurinol, suggesting a role for both inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO) in free radical formation. The radical formation was also suppressed in iNOS knockout (iNOS(-/-)) mice, demonstrating the involvement of iNOS. NADPH oxidase was not required in the formation of these radical adducts because the ESR signal intensity was increased by LPS treatment in NADPH oxidase knockout (gp91(phox-/-)) mice as much as it was in the wild-type mouse. Nitric oxide (*NO) end products were increased in LPS-treated skin. As expected, the *NO end products were not suppressed by allopurinol but were by aminoguanidine. Interestingly, nitrotyrosine formation in LPS-treated skin was also suppressed by aminoguanidine and allopurinol independently. Pretreatment with the ferric iron chelator Desferal had no effect on free radical formation. Our results imply that both iNOS and XO, but neither NADPH oxidase nor ferric iron, work synergistically to form lipid radical and nitrotyrosine early in the skin inflammation caused by LPS. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Nakai, Kozo AU - Kadiiska, Maria B AU - Jiang, Jin-Jie AU - Stadler, Krisztian AU - Mason, Ronald P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, MD F0-01, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 SP - 4616 EP - 4621 VL - 103 IS - 12 SN - 0027-8424, 0027-8424 KW - Enzyme Inhibitors KW - 0 KW - Free Radicals KW - Guanidines KW - Lipopolysaccharides KW - Allopurinol KW - 63CZ7GJN5I KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Xanthine Oxidase KW - EC 1.17.3.2 KW - pimagedine KW - SCQ4EZQ113 KW - Index Medicus KW - Animals KW - Allopurinol -- pharmacology KW - Electron Spin Resonance Spectroscopy KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Mice KW - Guanidines -- pharmacology KW - Xanthine Oxidase -- metabolism KW - Xanthine Oxidase -- antagonists & inhibitors KW - Skin -- enzymology KW - Skin -- drug effects KW - Skin -- metabolism KW - Nitric Oxide Synthase Type II -- antagonists & inhibitors KW - Lipopolysaccharides -- toxicity KW - Nitric Oxide Synthase Type II -- metabolism KW - Dermatitis -- enzymology KW - Free Radicals -- metabolism KW - Dermatitis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67773734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Determinants+of+Cancer+Disparities%3A+Barriers+to+Cancer+Screening%2C+Diagnosis%2C+and+Treatment&rft.au=Chu%2C+Kenneth+C&rft.aulast=Chu&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1994 Apr;310(1):118-25 [8161194] J Clin Invest. 1989 Apr;83(4):1137-43 [2539390] Nature. 1995 Jun 1;375(6530):408-11 [7539113] J Invest Dermatol. 1996 Jan;106(1):113-8 [8592060] Biochem Pharmacol. 1996 Jun 28;51(12):1727-38 [8687488] Chem Res Toxicol. 1996 Jul-Aug;9(5):845-50 [8828919] J Exp Med. 1996 Nov 1;184(5):2007-12 [8920887] Br J Dermatol. 1997 Jan;136(1):18-23 [9039289] J Clin Invest. 1997 Feb 15;99(4):635-42 [9045865] Chem Res Toxicol. 1997 Oct;10(10):1104-8 [9348432] J Clin Invest. 1998 Mar 1;101(5):967-71 [9486966] Br J Pharmacol. 1998 Apr;123(7):1325-30 [9579726] J Invest Dermatol. 1998 Jul;111(1):149-53 [9665402] Cancer Res. 1998 Nov 1;58(21):4832-9 [9809987] J Biol Chem. 1999 Apr 16;274(16):10689-92 [10196138] J Biol Chem. 1999 Apr 16;274(16):10802-6 [10196155] Free Radic Biol Med. 2005 Jan 1;38(1):125-35 [15589381] Am J Respir Crit Care Med. 2005 Feb 15;171(4):379-87 [15477498] Free Radic Biol Med. 2005 Oct 15;39(8):1050-8 [16198232] Curr Opin Microbiol. 2000 Feb;3(1):23-8 [10679425] Br J Pharmacol. 2000 May;130(1):90-4 [10781002] Nature. 2000 Aug 17;406(6797):782-7 [10963608] Chem Res Toxicol. 2001 Sep;14(9):1273-6 [11559043] Nat Rev Immunol. 2001 Nov;1(2):135-45 [11905821] J Trauma. 2002 Apr;52(4):683-7 [11956382] Nature. 2002 Sep 5;419(6902):77-81 [12214235] FASEB J. 2002 Nov;16(13):1713-20 [12409313] Pharmacol Res. 2002 Dec;46(6):557-64 [12457631] J Ethnopharmacol. 2003 Mar;85(1):33-41 [12576200] FASEB J. 2003 Apr;17(6):636-43 [12665476] Redox Rep. 2003;8(2):105-12 [12804013] FEBS Lett. 2004 Mar 26;562(1-3):129-33 [15044013] J Invest Dermatol. 2004 Apr;122(4):1000-9 [15102091] Diabetes. 2004 May;53(5):1344-51 [15111505] Spectrochim Acta A Mol Biomol Spectrosc. 2004 May;60(6):1371-7 [15134737] Biochimie. 2004 Jul;86(7):425-9 [15308331] Infect Immun. 2004 Sep;72(9):4933-9 [15321984] Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Aug;32(2):195-202 [302250] J Biol Chem. 1981 Sep 10;256(17):9006-103 [6267059] Cancer Res. 1987 Apr 1;47(7):1775-9 [3469021] FEBS Lett. 1987 Mar 9;213(1):23-8 [3030809] J Magn Reson B. 1994 Jun;104(2):105-10 [8049862] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Autoimmunity and Impaired T Cell Apoptosis in Wiskott-Aldrich Syndrome Protein Deficiency: A FasL Connection T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 40003814; 4143105 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Nikolov, Nikolay P Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - FasL protein KW - Protein deficiency KW - Apoptosis KW - Wiskott-Aldrich syndrome KW - Lymphocytes T KW - Autoimmunity KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Autoimmunity+and+Impaired+T+Cell+Apoptosis+in+Wiskott-Aldrich+Syndrome+Protein+Deficiency%3A+A+FasL+Connection&rft.au=Nikolov%2C+Nikolay+P&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Distinct Subset of MHC-Independent FoxP3+ T Cells Participates in the Control of Adaptive Immune Responses In Vivo T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39949670; 4143059 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Stephens, Geoffrey L Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes T UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Keratin+14+Expression+in+Mouse+Lung+Induces+Early+Squamous+Differentiation&rft.au=Dakir%2C+El+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=El&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstitution of Lymphopenic Mice with Limited T-Cell Repertoire Results in Severe Multiorgan Eosinophilic Disease T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39921172; 4143080 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Milner, Joshua D Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Mice KW - Lymphocytes T KW - Lymphopenia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Reconstitution+of+Lymphopenic+Mice+with+Limited+T-Cell+Repertoire+Results+in+Severe+Multiorgan+Eosinophilic+Disease&rft.au=Milner%2C+Joshua+D&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Expression of IRBP is Dispensable for Generation of CD4+CD25+ Regulatory T Cells that Protect Against IRBP-Induced Experimental Autoimmune Uveitis (EAU) T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39921107; 4143062 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Grajewski, Rafael S Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Experimental autoimmune uveitis KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Endogenous+Expression+of+IRBP+is+Dispensable+for+Generation+of+CD4%2BCD25%2B+Regulatory+T+Cells+that+Protect+Against+IRBP-Induced+Experimental+Autoimmune+Uveitis+%28EAU%29&rft.au=Grajewski%2C+Rafael+S&rft.aulast=Grajewski&rft.aufirst=Rafael&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of Pathogenic and Regulatory T Cells in a Model of Retinal Autoimmunity: Dependency on Innate Immune Responses T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913799; 4143074 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Caspi, Rachel R Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes T KW - Immunoregulation KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Generation+of+Pathogenic+and+Regulatory+T+Cells+in+a+Model+of+Retinal+Autoimmunity%3A+Dependency+on+Innate+Immune+Responses&rft.au=Caspi%2C+Rachel+R&rft.aulast=Caspi&rft.aufirst=Rachel&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR7/8 Gene Duplication in the Pseudoautosomal Region of Y-Linked Autoimmune Accelerating (Yaa) Mice T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913733; 4143068 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Bolland, Silvia Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Mice KW - Gene duplication KW - Toll-like receptors KW - TLR7 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Bisindolylmaleimide+and+Indolocarbazole+Protein+Kinase+%28PK%29+Inhibitors+Reverse+ABCG2-Mediated+Drug+Transport+and+Resistance&rft.au=Robey%2C+Robert+W%3BShukla%2C+Suneet%3BSteadman%2C+Kenneth%3BAmbudkar%2C+Suresh+V%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C-Abl Family Kinases Mediate Apoptosis in B Cells in Response to Fc Receptor Stimulation T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913684; 4143054 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Tzeng, Shiang-Jong Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes B KW - Apoptosis KW - Fc receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=C-Abl+Family+Kinases+Mediate+Apoptosis+in+B+Cells+in+Response+to+Fc+Receptor+Stimulation&rft.au=Tzeng%2C+Shiang-Jong&rft.aulast=Tzeng&rft.aufirst=Shiang-Jong&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polyclonal and Organ Specific CD4+CD25+Foxp3+ Regulatory T Cells (nTregs): Different Mechanisms of Suppressing Organ Specific Autoimmunity In Vivo T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39839852; 4143108 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - DiPaolo, Rich J Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Organs KW - Lymphocytes T KW - Immunoregulation KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Polyclonal+and+Organ+Specific+CD4%2BCD25%2BFoxp3%2B+Regulatory+T+Cells+%28nTregs%29%3A+Different+Mechanisms+of+Suppressing+Organ+Specific+Autoimmunity+In+Vivo&rft.au=DiPaolo%2C+Rich+J&rft.aulast=DiPaolo&rft.aufirst=Rich&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Sequence: Different Types of HIV-1 Strains are Likely to have been Introduced from Neighboring Countries to Mali. T2 - 6th Congress of the Federation of African Immunological Societies AN - 40116605; 4257138 JF - 6th Congress of the Federation of African Immunological Societies AU - Koita, Ousmane A AU - Cisse, Aissata B AU - Dao, Sounkalo AU - Sogoba, Dramane AU - Ibrah, Mahamadou AU - Dabitao, Djeneba AU - Traore, Abdel Kader AU - Tounkara, Anatole AU - Imamichi, Hiromi Y1 - 2006/03/20/ PY - 2006 DA - 2006 Mar 20 KW - Mali KW - Strains KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Congress+of+the+Federation+of+African+Immunological+Societies&rft.atitle=HIV-1+Sequence%3A+Different+Types+of+HIV-1+Strains+are+Likely+to+have+been+Introduced+from+Neighboring+Countries+to+Mali.&rft.au=Koita%2C+Ousmane+A%3BCisse%2C+Aissata+B%3BDao%2C+Sounkalo%3BSogoba%2C+Dramane%3BIbrah%2C+Mahamadou%3BDabitao%2C+Djeneba%3BTraore%2C+Abdel+Kader%3BTounkara%2C+Anatole%3BImamichi%2C+Hiromi&rft.aulast=Koita&rft.aufirst=Ousmane&rft.date=2006-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Congress+of+the+Federation+of+African+Immunological+Societies&rft.issn=&rft_id=info:doi/ L2 - http://www.faisoc.org/English/Conferences/6_Dakar/Dakar.Htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Actions Addressing the Obesity Epidemic and Research Directions for the Future T2 - 2nd National Conference on Obesity and Health AN - 39933517; 4204698 JF - 2nd National Conference on Obesity and Health AU - Hubbard, Van S Y1 - 2006/03/20/ PY - 2006 DA - 2006 Mar 20 KW - Obesity KW - Epidemics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+National+Conference+on+Obesity+and+Health&rft.atitle=National+Actions+Addressing+the+Obesity+Epidemic+and+Research+Directions+for+the+Future&rft.au=Hubbard%2C+Van+S&rft.aulast=Hubbard&rft.aufirst=Van&rft.date=2006-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+National+Conference+on+Obesity+and+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.obesityandhealth.co.uk/programme_2006.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-Inflammatory Actions T2 - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AN - 40005946; 4141862 JF - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AU - Cidlowski, John A Y1 - 2006/03/18/ PY - 2006 DA - 2006 Mar 18 KW - Translation KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nucleotide+Damage+Proximal+to+DNA+Double-Strand+Break+ends+is+a+Stronger+Inhibitor+of+Non-Homologous+end+Joining+than+Blocked+3+Ends&rft.au=Datta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Datta&rft.aufirst=Kamal&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=815 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Physiological Gene Responsiveness in ERKO Mice T2 - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AN - 39847905; 4141827 JF - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AU - Korach, Kenneth S Y1 - 2006/03/18/ PY - 2006 DA - 2006 Mar 18 KW - Mice KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39847905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28X4%29&rft.atitle=Differential+Physiological+Gene+Responsiveness+in+ERKO+Mice&rft.au=Korach%2C+Kenneth+S&rft.aulast=Korach&rft.aufirst=Kenneth&rft.date=2006-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=815 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Astrocytes promote myelination in response to electrical impulses. AN - 67764440; 16543131 AB - Myelin, the insulating layers of membrane wrapped around axons by oligodendrocytes, is essential for normal impulse conduction. It forms during late stages of fetal development but continues into early adult life. Myelination correlates with cognitive development and can be regulated by impulse activity through unknown molecular mechanisms. Astrocytes do not form myelin, but these nonneuronal cells can promote myelination in ways that are not understood. Here, we identify a link between myelination, astrocytes, and electrical impulse activity in axons that is mediated by the cytokine leukemia inhibitory factor (LIF). These findings show that LIF is released by astrocytes in response to ATP liberated from axons firing action potentials, and LIF promotes myelination by mature oligodendrocytes. This activity-dependent mechanism promoting myelination could regulate myelination according to functional activity or environmental experience and may offer new approaches to treating demyelinating diseases. JF - Neuron AU - Ishibashi, Tomoko AU - Dakin, Kelly A AU - Stevens, Beth AU - Lee, Philip R AU - Kozlov, Serguei V AU - Stewart, Colin L AU - Fields, R Douglas AD - Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. Y1 - 2006/03/16/ PY - 2006 DA - 2006 Mar 16 SP - 823 EP - 832 VL - 49 IS - 6 SN - 0896-6273, 0896-6273 KW - Anesthetics, Local KW - 0 KW - Antibodies KW - Azo Compounds KW - Bearded protein, Drosophila KW - DNA-Binding Proteins KW - Drosophila Proteins KW - Interleukin-6 KW - Leukemia Inhibitory Factor KW - Lif protein, mouse KW - MOG protein, human KW - Mog protein, mouse KW - Mog protein, rat KW - Myelin Basic Protein KW - Myelin Proteins KW - Myelin-Associated Glycoprotein KW - Myelin-Oligodendrocyte Glycoprotein KW - Naphthalenes KW - O Antigens KW - RNA, Messenger KW - Thionucleotides KW - Adenosine-5'-(N-ethylcarboxamide) KW - 35920-39-9 KW - 2-methylthio-ATP KW - 43170-89-4 KW - Tetrodotoxin KW - 4368-28-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Sudan Black B KW - 9YDL1Q990E KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Gene Expression -- drug effects KW - Axons -- radiation effects KW - Animals KW - Cerebral Cortex -- cytology KW - Drug Interactions KW - Neurons -- drug effects KW - Adenosine-5'-(N-ethylcarboxamide) -- pharmacology KW - Blotting, Western -- methods KW - Models, Biological KW - RNA, Messenger -- biosynthesis KW - Rats KW - Antibodies -- pharmacology KW - Adenosine Triphosphate -- analogs & derivatives KW - Neurons -- physiology KW - Myelin Basic Protein -- metabolism KW - Interleukin-6 -- immunology KW - Stem Cells KW - Time Factors KW - Drosophila Proteins -- metabolism KW - Embryo, Mammalian KW - DNA-Binding Proteins -- metabolism KW - Action Potentials -- physiology KW - Axons -- drug effects KW - Anesthetics, Local -- pharmacology KW - Coculture Techniques -- methods KW - Action Potentials -- radiation effects KW - Dose-Response Relationship, Drug KW - Interleukin-6 -- metabolism KW - Mice KW - Immunohistochemistry -- methods KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Ganglia, Spinal -- cytology KW - Thionucleotides -- pharmacology KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Adenosine -- pharmacology KW - Axons -- metabolism KW - O Antigens -- metabolism KW - Cell Count -- methods KW - Cells, Cultured KW - Neurons -- cytology KW - Adenosine Triphosphate -- metabolism KW - Myelin-Associated Glycoprotein -- metabolism KW - Tetrodotoxin -- pharmacology KW - Adenosine Triphosphate -- pharmacology KW - Cell Communication -- radiation effects KW - Electric Stimulation -- methods KW - Cell Communication -- drug effects KW - Astrocytes -- physiology KW - Cell Communication -- physiology KW - Astrocytes -- radiation effects KW - Myelin Proteins -- metabolism KW - Oligodendroglia -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67764440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+DLC-1+Tumor+Suppressor+Gene+Expression+in+Breast+Cancer+Cells+by+Proapoptotic+Dietary+Flavone+and+its+Potential+Implication+in+Chemoprevetion&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicolae+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1993 Jan 21;361(6409):258-60 [8093806] Nature. 1992 Sep 3;359(6390):76-9 [1522892] Development. 1989 May;106(1):119-32 [2697546] J Neuroimmunol. 1989 May;22(3):169-76 [2649509] Ann N Y Acad Sci. 2004 Jun;1021:77-85 [15251877] Curr Top Med Chem. 2004;4(8):793-803 [15078211] Sci Am. 2004 Apr;290(4):54-61 [15045754] Neuron. 2002 Dec 5;36(5):855-68 [12467589] J Neurosci. 2002 Nov 1;22(21):9221-7 [12417647] Development. 1994 Jan;120(1):143-53 [8119123] Cell Tissue Res. 2002 Nov;310(2):155-61 [12397370] Science. 2002 Oct 18;298(5593):556-62 [12386325] Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):391-4 [12175878] Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):259-68 [12175861] J Neuroimmunol. 2002 Aug;129(1-2):43-50 [12161019] Nat Med. 2002 Jun;8(6):613-9 [12042813] Dev Neurosci. 2001;23(4-5):327-37 [11756748] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7109-13 [8041754] Science. 1995 Nov 24;270(5240):1369-72 [7481827] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9887-92 [8790426] Neuron. 1996 Oct;17(4):607-15 [8893019] J Neurobiol. 1998 Sep 15;36(4):509-24 [9740023] J Neurosci. 1998 Nov 15;18(22):9303-11 [9801369] Folia Neuropathol. 1999;37(2):81-6 [10464425] Nat Neurosci. 2005 Sep;8(9):1148-50 [16116456] Hum Brain Mapp. 2005 Oct;26(2):139-47 [15858815] Neuroscientist. 2005 Dec;11(6):528-31 [16282593] Mol Cell Neurosci. 1999 Oct-Nov;14(4-5):385-97 [10588392] Science. 2000 Mar 24;287(5461):2267-71 [10731149] Trends Neurosci. 2000 Dec;23(12):625-33 [11137153] Comment In: Neuron. 2006 Mar 16;49(6):777-8 [16543121] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886. AN - 67773084; 16551867 AB - The small molecular inhibitor MK886 is known to block 5-lipoxygenase-activating protein ALOX5AP and shows antitumor activity in multiple human cell lines. The broad antitumor therapeutic window reported in vivo for MK886 in rodents supports further consideration of this structural class. Better understanding of the mode of action of the drug is important for application in humans to take place. Affymetrix microarray study was conducted to explore MK886 pharmacologic mechanism. Ingenuity Pathway Analysis software was applied to validate the results at the transcriptional level by putting them in the context of an experimental proteomic network. Genes most affected by MK886 included actin B and focal adhesion components. A subsequent National Cancer Institute-60 panel study, RT-PCR validation followed by confocal microscopy, and Western blotting also pointed to actin B down-regulation, filamentous actin loss, and disorganization of the transcription machinery. In agreement with these observations, MK886 was found to enhance the effect of UV radiation in H720 lung cancer cell line. In light of the modification of cytoskeleton and cell motility by lipid phosphoinositide 3-kinase products, MK886 interaction with actin B might be biologically important. The low toxicity of MK886 in vivo was modeled and explained by binding and transport by dietary lipids. The rate of lipid absorbance is generally higher for tumors, suggesting a promise of a targeted liposome-based delivery system for this drug. These results suggest a novel antitumor pharmacologic mechanism. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Mayburd, Anatoly L AU - Martlínez, Alfredo AU - Sackett, Daniel AU - Liu, Huaitian AU - Shih, Joanna AU - Tauler, Jordy AU - Avis, Ingalill AU - Mulshine, James L AD - Intervention Section, National Cancer Institute, NIH, Bethesda, MD 20859, USA. mayburna@mail.nih.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 1820 EP - 1827 VL - 12 IS - 6 SN - 1078-0432, 1078-0432 KW - Actins KW - 0 KW - Indoles KW - Lipoxygenase Inhibitors KW - MK-886 KW - 080626SQ8C KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Cytoskeleton -- metabolism KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - Actins -- metabolism KW - Cell Line, Tumor KW - Signal Transduction -- radiation effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Cytoskeleton -- drug effects KW - Blotting, Western KW - Actins -- genetics KW - Lipoxygenase Inhibitors -- pharmacology KW - Signal Transduction -- drug effects KW - Signal Transduction -- genetics KW - Gene Expression Regulation, Neoplastic -- radiation effects KW - Cytoskeleton -- radiation effects KW - Gene Expression Profiling KW - Transcription, Genetic -- drug effects KW - Transcription, Genetic -- radiation effects KW - Indoles -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67773084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Ingenuity+network-assisted+transcription+profiling%3A+Identification+of+a+new+pharmacologic+mechanism+for+MK886.&rft.au=Mayburd%2C+Anatoly+L%3BMartl%C3%ADnez%2C+Alfredo%3BSackett%2C+Daniel%3BLiu%2C+Huaitian%3BShih%2C+Joanna%3BTauler%2C+Jordy%3BAvis%2C+Ingalill%3BMulshine%2C+James+L&rft.aulast=Mayburd&rft.aufirst=Anatoly&rft.date=2006-03-15&rft.volume=12&rft.issue=6&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pooled analysis of second primary pancreatic cancer. AN - 67717857; 16421239 AB - Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries with a registration period up to year 2000. Cancer patients were followed up from the initial cancer diagnosis, and the occurrence of second primary malignant neoplasms was compared with expected values derived from local rates, adjusting for age, sex, and period of diagnosis. Results from individual registries were pooled by use of a fixed-effects model. People were at higher risk of developing pancreatic cancer within 10 years of a diagnosis of cancers of the pharynx, stomach, gallbladder, larynx, lung, cervix, corpus uteri, bladder, and eye and 10 years or later following a diagnosis of cancers of the stomach, colon, gallbladder, breast, cervix, placenta, corpus uteri, ovary, testis, bladder, kidney, and eye, as well as Hodgkin's and non-Hodgkin's lymphomas. Pancreatic cancer was connected with smoking-related cancers, confirming the etiologic role of tobacco. The associations with uterine and ovarian cancers suggest that reproductive factors might be implicated in pancreatic carcinogenesis. The elevated pancreatic cancer risk in young patients observed among several types of cancer implies a role of genetic factors. Radiotherapy is also suggested as a risk factor. JF - American journal of epidemiology AU - Shen, Min AU - Boffetta, Paolo AU - Olsen, Jørgen H AU - Andersen, Aage AU - Hemminki, Kari AU - Pukkala, Eero AU - Tracey, Elizabeth AU - Brewster, David H AU - McBride, Mary L AU - Pompe-Kirn, Vera AU - Kliewer, Erich V AU - Tonita, Jon M AU - Chia, Kee-Seng AU - Martos, Carmen AU - Jonasson, Jon G AU - Colin, Didier AU - Scélo, Ghislaine AU - Brennan, Paul AD - International Agency for Research on Cancer, Lyon, France. shenmi@mail.nih.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 502 EP - 511 VL - 163 IS - 6 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Registries KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Neoplasms, Second Primary -- epidemiology KW - Smoking -- adverse effects KW - Pancreatic Neoplasms -- epidemiology KW - Risk Assessment KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67717857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=A+pooled+analysis+of+second+primary+pancreatic+cancer.&rft.au=Shen%2C+Min%3BBoffetta%2C+Paolo%3BOlsen%2C+J%C3%B8rgen+H%3BAndersen%2C+Aage%3BHemminki%2C+Kari%3BPukkala%2C+Eero%3BTracey%2C+Elizabeth%3BBrewster%2C+David+H%3BMcBride%2C+Mary+L%3BPompe-Kirn%2C+Vera%3BKliewer%2C+Erich+V%3BTonita%2C+Jon+M%3BChia%2C+Kee-Seng%3BMartos%2C+Carmen%3BJonasson%2C+Jon+G%3BColin%2C+Didier%3BSc%C3%A9lo%2C+Ghislaine%3BBrennan%2C+Paul&rft.aulast=Shen&rft.aufirst=Min&rft.date=2006-03-15&rft.volume=163&rft.issue=6&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. AN - 67702627; 16446309 AB - Smith-Lemli-Opitz syndrome (SLOS) is a genetic syndrome caused by mutations in the 3beta-hydroxysterol Delta(7)-reductase gene (DHCR7). SLOS patients have decreased cholesterol and increased 7-dehydrocholesterol (7-DHC) levels. Dietary cholesterol supplementation improves systemic biochemical abnormalities; however, because of the blood-brain barrier, the central nervous system (CNS) is not treated. Simvastatin therapy has been proposed as a means to treat the CNS. Mice homozygous for a null disruption of Dhcr7, Dhcr7(Delta3-5/Delta3-5), die soon after birth, thus they cannot be used to study postnatal development or therapy. To circumvent this problem, we produced a hypomorphic SLOS mouse model by introducing a mutation corresponding to DHCR7(T93M). Both Dhcr7(T93M/T93M) and Dhcr7(Delta3-5/T93M) mice are viable. Phenotypic findings in Dhcr7(T93M/Delta3-5) mice include CNS ventricular dilatation and two to three syndactyly. Biochemically, both Dhcr7(T93M/T93M) and Dhcr7(T93M/Delta3-5) mice have elevated tissue 7-DHC levels; however, the biochemical defect improved with age. This has not been observed in human patients, and is due to elevated Dhcr7 expression in mouse tissues. Dietary cholesterol therapy improved sterol profiles in peripheral, but not CNS tissues. However, treatment of Dhcr7(T93M/Delta3-5) mice with simvastatin decreased 7-DHC levels in both peripheral and brain tissues. Expression of Dhcr7 increased in Dhcr7(T93M/Delta3-5) tissues after simvastatin therapy, consistent with the hypothesis that simvastatin therapy improves the biochemical phenotype by increasing the expression of a Dhcr7 allele with residual enzymatic activity. We conclude that simvastatin treatment is efficacious in improving the SLOS-associated sterol abnormality found in the brain, and thus has the potential to be an effective therapeutic intervention for behavioral and learning problems associated with SLOS. JF - Human molecular genetics AU - Correa-Cerro, Lina S AU - Wassif, Christopher A AU - Kratz, Lisa AU - Miller, Georgina F AU - Munasinghe, Jeeva P AU - Grinberg, Alexander AU - Fliesler, Steven J AU - Porter, Forbes D AD - Unit on Molecular Dysmorphology, Heritable Disorders Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 839 EP - 851 VL - 15 IS - 6 SN - 0964-6906, 0964-6906 KW - Threonine KW - 2ZD004190S KW - Methionine KW - AE28F7PNPL KW - Simvastatin KW - AGG2FN16EV KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - 7-dehydrocholesterol reductase KW - EC 1.3.1.21 KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Threonine -- genetics KW - Mice KW - Magnetic Resonance Spectroscopy KW - Phenotype KW - Mutagenesis, Site-Directed KW - Methionine -- genetics KW - Alleles KW - Embryonic Stem Cells -- transplantation KW - Amino Acid Substitution -- genetics KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Female KW - Simvastatin -- therapeutic use KW - Smith-Lemli-Opitz Syndrome -- drug therapy KW - Disease Models, Animal KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Smith-Lemli-Opitz Syndrome -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67702627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Development+and+characterization+of+a+hypomorphic+Smith-Lemli-Opitz+syndrome+mouse+model+and+efficacy+of+simvastatin+therapy.&rft.au=Correa-Cerro%2C+Lina+S%3BWassif%2C+Christopher+A%3BKratz%2C+Lisa%3BMiller%2C+Georgina+F%3BMunasinghe%2C+Jeeva+P%3BGrinberg%2C+Alexander%3BFliesler%2C+Steven+J%3BPorter%2C+Forbes+D&rft.aulast=Correa-Cerro&rft.aufirst=Lina&rft.date=2006-03-15&rft.volume=15&rft.issue=6&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humans. AN - 67701092; 16144747 AB - The rate hypothesis of psychoactive drug action holds that the faster a drug reaches the brain and starts to act, the greater its reinforcing effects and abuse liability. A previous human study using a single cocaine dose confirmed the rate hypothesis for subjective responses, but found no rate effect on cardiovascular responses. We evaluated the rate hypothesis in 17 experienced cocaine users (7 [all men] provided complete data; 6 participated in only 1-2 sessions) by administering IV cocaine at each of three doses (10, 25, 50 mg) and injection durations (10, 30, 60 s) in a double-blind, placebo-controlled, escalating dose design. Heart rate, blood pressure, and positive (e.g., rush, high) and negative (e.g., feel bad, anxious) subjective effects (100-mm visual analogue scales) were measured for 1h after dosing. Peak change from baseline, time to peak, and area under the time-response curve were evaluated with repeated measures mixed linear regression analyses, allowing use of data from all sessions for all subjects, including non-completers. Both dose (mg) and infusion rate (mg/s) significantly influenced most subjective and cardiovascular variables. Analysis of the interaction suggested that dose had a stronger impact than rate. Rate had a stronger influence on positive subjective effects than on negative subjective effects or cardiovascular variables. These findings provide support for the rate hypothesis as it applies to both subjective and cardiovascular effects of IV cocaine administration in humans. JF - Drug and alcohol dependence AU - Nelson, Richard A AU - Boyd, Susan J AU - Ziegelstein, Roy C AU - Herning, Ronald AU - Cadet, Jean L AU - Henningfield, Jack E AU - Schuster, Charles R AU - Contoreggi, Carlo AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health & Human Services, Baltimore, MD 21224, USA. Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 19 EP - 24 VL - 82 IS - 1 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Electrocardiography KW - Electroencephalography KW - Adult KW - Male KW - Prevalence KW - Heart Rate -- drug effects KW - Anxiety -- chemically induced KW - Cocaine-Related Disorders -- physiopathology KW - Substance Abuse, Intravenous -- physiopathology KW - Substance Abuse, Intravenous -- epidemiology KW - Periodicity KW - Cocaine-Related Disorders -- epidemiology KW - Blood Pressure -- drug effects KW - Cocaine -- adverse effects KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67701092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Effect+of+rate+of+administration+on+subjective+and+physiological+effects+of+intravenous+cocaine+in+humans.&rft.au=Nelson%2C+Richard+A%3BBoyd%2C+Susan+J%3BZiegelstein%2C+Roy+C%3BHerning%2C+Ronald%3BCadet%2C+Jean+L%3BHenningfield%2C+Jack+E%3BSchuster%2C+Charles+R%3BContoreggi%2C+Carlo%3BGorelick%2C+David+A&rft.aulast=Nelson&rft.aufirst=Richard&rft.date=2006-03-15&rft.volume=82&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Borrelia burgdorferi Lipoprotein-Mediated TLR2 Stimulation Causes the Down-Regulation of TLR5 in Human Monocytes AN - 17092970; 6725963 AB - Toll-like receptors (TLRs) trigger innate immune responses via the recognition of conserved pathogen-associated molecular patterns. Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease, activate inflammatory cells through TLR2 and TLR1. We show that stimulation of human monocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipopeptide Pam sub(3)CysSerLys sub(4) results in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for bacterial flagellin, and that this effect is mediated via TLR2. TLR4 stimulation had no effect on TLR2, TLR1, and TLRS expression. Human monocytes stimulated with TLR5 ligands (including p37 or flaA, the minor protein from B. burgdorferi flagella) up-regulated TLR5. In addition, TLR2 stimulation rendered cells hyporesponsive to a TLR5 agonist. There results indicate that diverse stimuli can cause differential TLR expression, and we hypothesize that these changes may be useful for either the pathogen and/or the host. JF - Journal of Infectious Diseases AU - Cabral, E S AU - Gelderblom, H AU - Hornung, R L AU - Munson, P J AU - Martin, R AU - Marques, A R AD - ClinicaI Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, and Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 849 EP - 859 VL - 193 IS - 6 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Borrelia burgdorferi KW - TLR2 protein KW - TLR5 protein KW - Inflammatory diseases KW - outer surface protein A KW - Lipoproteins KW - Monocytes KW - lipopeptides KW - Flagellin KW - TLR4 protein KW - Toll-like receptors KW - Flagella KW - Lyme disease KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17092970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Borrelia+burgdorferi+Lipoprotein-Mediated+TLR2+Stimulation+Causes+the+Down-Regulation+of+TLR5+in+Human+Monocytes&rft.au=Cabral%2C+E+S%3BGelderblom%2C+H%3BHornung%2C+R+L%3BMunson%2C+P+J%3BMartin%2C+R%3BMarques%2C+A+R&rft.aulast=Cabral&rft.aufirst=E&rft.date=2006-03-15&rft.volume=193&rft.issue=6&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - outer surface protein A; Inflammatory diseases; TLR5 protein; Lipoproteins; TLR2 protein; Monocytes; lipopeptides; TLR4 protein; Flagellin; Toll-like receptors; Lyme disease; Flagella; Borrelia burgdorferi ER - TY - JOUR T1 - A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. AN - 67740976; 16481597 AB - Creatine and minocycline were prioritized for testing in Phase II clinical trials based on a systematic evaluation of potentially disease modifying compounds for Parkinson disease (PD). To test whether creatine and minocycline alter the course of early PD relative to a predetermined futility threshold for progression of PD in a randomized, double-blind, Phase II futility clinical trial. Agents that do not perform better than the futility threshold are rejected as futile and are not considered for further study. Participants had a diagnosis of PD within 5 years, but did not require medications for the management of symptoms. The primary outcome was the change in the total Unified Parkinson's Disease Rating Scale (UPDRS) score from baseline to either the time when there was sufficient disability to warrant symptomatic therapy for PD or 12 months, whichever came first. Subjects were randomized 1:1:1 to receive creatine 10 g/day, minocycline 200 mg/day, or matching placebo. The futility threshold was set as a 30% reduction in UPDRS progression based on the placebo/tocopherol arm of the Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism (DATATOP) trial. p values < or = 0.1 indicate futility. Two hundred subjects were randomized to the three groups. Neither creatine (p = 0.96) nor minocycline (p = 0.66) could be rejected as futile based on the DATATOP futility threshold. The rate of progression for the calibration placebo group fell outside the 95% CI for the DATATOP historical control. In a sensitivity analysis, based on the threshold derived from the calibration placebo group, again neither drug could be rejected as futile. Tolerability was 91% in the creatine group and 77% in the minocycline group. Common adverse events included upper respiratory symptoms (26%), joint pain (19%), and nausea (17%). Both creatine and minocycline should be considered for definitive Phase III trials to determine if they alter the long term progression of Parkinson disease (PD). Additional factors must be weighed before selecting agents for Phase III trials, including safety, tolerability, activity, cost, and availability of these two agents in comparison with other agents currently in development for PD. JF - Neurology AU - NINDS NET-PD Investigators AD - NINDS NET-PD Investigators Y1 - 2006/03/14/ PY - 2006 DA - 2006 Mar 14 SP - 664 EP - 671 VL - 66 IS - 5 KW - Anti-Bacterial Agents KW - 0 KW - Minocycline KW - FYY3R43WGO KW - Creatine KW - MU72812GK0 KW - Abridged Index Medicus KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Double-Blind Method KW - Humans KW - Aged KW - Middle Aged KW - Anti-Bacterial Agents -- toxicity KW - Disabled Persons KW - Male KW - Female KW - Minocycline -- toxicity KW - Creatine -- toxicity KW - Creatine -- therapeutic use KW - Parkinson Disease -- physiopathology KW - Minocycline -- therapeutic use KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67740976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=A+randomized%2C+double-blind%2C+futility+clinical+trial+of+creatine+and+minocycline+in+early+Parkinson+disease.&rft.au=NINDS+NET-PD+Investigators&rft.aulast=NINDS+NET-PD+Investigators&rft.aufirst=&rft.date=2006-03-14&rft.volume=66&rft.issue=5&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-24 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 2006 Mar 14;66(5):626-7 [16534098] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Prevalence of Recognized and Unrecognized Myocardial Infarction: The ICELAND MI Substudy to the AGES-Reykjavik Study T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40129299; 4154567 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Arai, Andrew E AU - Cao, Jie J AU - Sigurdsson, Sigurdur AU - Jonasson, Torfi AU - Vincent, Pamela AU - Kellman, Peter AU - Aletras, Anthony H AU - Aspelund, Thor AU - Thorgeirsson, Gudmunder AU - Launer, Lenore AU - Eiriksdottir, Gudny AU - Harris, Tamara AU - Gudnason, Vilmundur Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Atlantic, Iceland KW - Myocardial infarction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Prevalence+of+Recognized+and+Unrecognized+Myocardial+Infarction%3A+The+ICELAND+MI+Substudy+to+the+AGES-Reykjavik+Study&rft.au=Arai%2C+Andrew+E%3BCao%2C+Jie+J%3BSigurdsson%2C+Sigurdur%3BJonasson%2C+Torfi%3BVincent%2C+Pamela%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BAspelund%2C+Thor%3BThorgeirsson%2C+Gudmunder%3BLauner%2C+Lenore%3BEiriksdottir%2C+Gudny%3BHarris%2C+Tamara%3BGudnason%2C+Vilmundur&rft.aulast=Arai&rft.aufirst=Andrew&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relation Between Aortic Distensibility and Calcified Aortic Atherosclerosis: Cardiovascular Magentic Resonance Imaging and Computed Tomography Correlations T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40124934; 4154940 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Cao, Jie J AU - Gudnason, Vilmundur AU - Pang, Johnny AU - Johannes, Jimmy AU - Karlsdottir, Gyda AU - Sigurdsson, Sigurdur AU - Bandettini, W Patricia AU - Eiriksdottir, Gudny AU - Launer, Lenore AU - Harris, Tamara AU - Arai, Andrew E Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Arteriosclerosis KW - Imaging techniques KW - Computed tomography KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=The+Relation+Between+Aortic+Distensibility+and+Calcified+Aortic+Atherosclerosis%3A+Cardiovascular+Magentic+Resonance+Imaging+and+Computed+Tomography+Correlations&rft.au=Cao%2C+Jie+J%3BGudnason%2C+Vilmundur%3BPang%2C+Johnny%3BJohannes%2C+Jimmy%3BKarlsdottir%2C+Gyda%3BSigurdsson%2C+Sigurdur%3BBandettini%2C+W+Patricia%3BEiriksdottir%2C+Gudny%3BLauner%2C+Lenore%3BHarris%2C+Tamara%3BArai%2C+Andrew+E&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship Between Cardiopulmonary Exercise Testing and Pulmonary Pressures in Hypertrophic Cardiomyopathy T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 39161912; 4155107 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Arena, Ross AU - Owens, David S AU - Smith, Kevin AU - Mohiddin, Saidi A AU - McAreavey, Dorothea AU - Ulisney, Karen L AU - Fananapazir, Lameh AU - Plehn, Jonathan F Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Cardiomyopathy KW - Lung KW - Pressure KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39161912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Relationship+Between+Cardiopulmonary+Exercise+Testing+and+Pulmonary+Pressures+in+Hypertrophic+Cardiomyopathy&rft.au=Arena%2C+Ross%3BOwens%2C+David+S%3BSmith%2C+Kevin%3BMohiddin%2C+Saidi+A%3BMcAreavey%2C+Dorothea%3BUlisney%2C+Karen+L%3BFananapazir%2C+Lameh%3BPlehn%2C+Jonathan+F&rft.aulast=Arena&rft.aufirst=Ross&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Design and Synthesis of Promiscuous High-Affinity Monoamine Transporter Ligands: Unraveling Transporter Selectivity AN - 19394510; 7159766 AB - A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). All of the compounds showed high binding affinities for the DAT in the low to subnanomolar range. Their ability to bind to the SERT and the NET, while maintaining their high affinity for the DAT, could be altered by substitution in positions C2 and C3 of the phenylpropyl side-chain. This approach gave rise to a new set of compounds with selectivity for the DAT, the DAT and the SERT, or the DAT and the NET. Six compounds (7, 9, 11, 12, 14, and 20) with relatively low SERT/DAT ratios were selected for additional study in biogenic amine uptake inhibition assays based on the biogenic amine transporter binding results. Some of the new ligands can serve as pharmacological tools to block DAT or DAT and another transporter simultaneously. JF - Journal of Medicinal Chemistry AU - Greiner, E AU - Boos, T L AU - Prisinzano, TE AU - De Martino, MG AU - Zeglis, B AU - Dersch, C M AU - Marcus, J AU - Partilla, J S AU - Rothman, R B AU - Jacobson, A E AU - Rice, K C AD - Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA Y1 - 2006/03/09/ PY - 2006 DA - 2006 Mar 09 SP - 1766 EP - 1772 VL - 49 IS - 5 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Biogenic amines KW - Dopamine transporter KW - Norepinephrine transporter KW - Monoamine transporter KW - Serotonin transporter KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Design+and+Synthesis+of+Promiscuous+High-Affinity+Monoamine+Transporter+Ligands%3A+Unraveling+Transporter+Selectivity&rft.au=Greiner%2C+E%3BBoos%2C+T+L%3BPrisinzano%2C+TE%3BDe+Martino%2C+MG%3BZeglis%2C+B%3BDersch%2C+C+M%3BMarcus%2C+J%3BPartilla%2C+J+S%3BRothman%2C+R+B%3BJacobson%2C+A+E%3BRice%2C+K+C&rft.aulast=Greiner&rft.aufirst=E&rft.date=2006-03-09&rft.volume=49&rft.issue=5&rft.spage=1766&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050766f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dopamine transporter; Serotonin transporter; Biogenic amines; Norepinephrine transporter; Monoamine transporter DO - http://dx.doi.org/10.1021/jm050766f ER - TY - CPAPER T1 - Altered TGF-Beta Function in Temporomandibular Joint Osteoarthritis T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 40005129; 4202731 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Embree, M AU - Bi, Y. AU - Wadhwa, S AU - Ameye, L AU - Wimer, H AU - Li, L. AU - Young, M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Temporomandibular joint KW - Transforming growth factor-^b KW - Osteoarthritis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Altered+TGF-Beta+Function+in+Temporomandibular+Joint+Osteoarthritis&rft.au=Embree%2C+M%3BBi%2C+Y.%3BWadhwa%2C+S%3BAmeye%2C+L%3BWimer%2C+H%3BLi%2C+L.%3BYoung%2C+M&rft.aulast=Embree&rft.aufirst=M&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salivary Biomarkers in Parotid Saliva of Sjogren's Syndrome T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39996627; 4204422 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Atkinson, J C AU - Ryu, O AU - Hoehn, G AU - Illei, G AU - Hart, T Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Bioindicators KW - Sjogren's syndrome KW - Saliva KW - Biomarkers KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39996627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Salivary+Biomarkers+in+Parotid+Saliva+of+Sjogren%27s+Syndrome&rft.au=Atkinson%2C+J+C%3BRyu%2C+O%3BHoehn%2C+G%3BIllei%2C+G%3BHart%2C+T&rft.aulast=Atkinson&rft.aufirst=J&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Craniofacial and Intraoral Soft Tissue Findings in Hyper-IgE Syndrome Patients T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39975428; 4202788 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Domingo, D L AU - Tomona, N AU - Singh, G D AU - Hart, T Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Soft tissues KW - Job's syndrome KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39975428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Craniofacial+and+Intraoral+Soft+Tissue+Findings+in+Hyper-IgE+Syndrome+Patients&rft.au=Domingo%2C+D+L%3BTomona%2C+N%3BSingh%2C+G+D%3BHart%2C+T&rft.aulast=Domingo&rft.aufirst=D&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Mammalian-SIRT, Homolog of Yeast-Sir2-Protein during Adipogenesis and Calorie-Restriction T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39944732; 4203555 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Liu, S AU - Michishita, E AU - Nunez, N AU - Hursting, S AU - Barrett, C AU - Horikawa, I Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Adipogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Analysis+of+Mammalian-SIRT%2C+Homolog+of+Yeast-Sir2-Protein+during+Adipogenesis+and+Calorie-Restriction&rft.au=Liu%2C+S%3BMichishita%2C+E%3BNunez%2C+N%3BHursting%2C+S%3BBarrett%2C+C%3BHorikawa%2C+I&rft.aulast=Liu&rft.aufirst=S&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FGF-Receptors Regulate Laminina5 and MMPs Expression During Submandibular Gland Morphogenesis T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39930242; 4204437 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Layvey, A AU - Rebustini, I AU - Hoffman, M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Morphogenesis KW - Submandibular gland KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=FGF-Receptors+Regulate+Laminina5+and+MMPs+Expression+During+Submandibular+Gland+Morphogenesis&rft.au=Layvey%2C+A%3BRebustini%2C+I%3BHoffman%2C+M&rft.aulast=Layvey&rft.aufirst=A&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Periodontal Disease Severity Using Partial Recording Protocols T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39922668; 4202632 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Kingman, A AU - Susin, C AU - Albandar, J M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Periodontal diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Assessing+Periodontal+Disease+Severity+Using+Partial+Recording+Protocols&rft.au=Kingman%2C+A%3BSusin%2C+C%3BAlbandar%2C+J+M&rft.aulast=Kingman&rft.aufirst=A&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. AN - 67749098; 16537462 AB - Calcium channels in the plasma membrane rarely remain open for much more than a millisecond at any one time, which avoids raising intracellular calcium to toxic levels. However, the dihydropyridine-sensitive calcium channels of the CaV1 family, which selectively couple electrical excitation to endocrine secretion, cardiovascular contractility, and neuronal transcription, have a unique second mode of gating, "mode 2," that involves frequent openings of much longer duration. Here we report that two human conditions, cyclosporin neurotoxicity and Timothy syndrome, increase mode 2 gating of the recombinant rabbit CaV1.2 channel. In each case, mode 2 gating depends on a Ser residue at the cytoplasmic end of the S6 helix in domain I (Ser-439, Timothy syndrome) or domain IV (Ser-1517, cyclosporin). Both Ser reside in consensus sequences for type II calmodulin-dependent protein kinase. Pharmacologically inhibiting type II calmodulin-dependent protein kinase or mutating the Ser residues to Ala prevents the increase in mode 2 gating. We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Erxleben, Christian AU - Liao, Yanhong AU - Gentile, Saverio AU - Chin, David AU - Gomez-Alegria, Claudio AU - Mori, Yasuo AU - Birnbaumer, Lutz AU - Armstrong, David L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3932 EP - 3937 VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Calcium Channels, L-Type KW - 0 KW - L-type calcium channel alpha(1C) KW - Recombinant Proteins KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Animals KW - Models, Molecular KW - Humans KW - Rabbits KW - Recombinant Proteins -- genetics KW - Ion Channel Gating -- drug effects KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Syndrome KW - In Vitro Techniques KW - Point Mutation KW - Recombinant Proteins -- chemistry KW - Amino Acid Substitution KW - Protein Conformation KW - Calcium Channels, L-Type -- drug effects KW - Metal Metabolism, Inborn Errors -- genetics KW - Metal Metabolism, Inborn Errors -- metabolism KW - Calcium Channels, L-Type -- chemistry KW - Calcium Channels, L-Type -- metabolism KW - Cyclosporine -- toxicity KW - Calcium Channels, L-Type -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67749098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Cyclosporin+and+Timothy+syndrome+increase+mode+2+gating+of+CaV1.2+calcium+channels+through+aberrant+phosphorylation+of+S6+helices.&rft.au=Erxleben%2C+Christian%3BLiao%2C+Yanhong%3BGentile%2C+Saverio%3BChin%2C+David%3BGomez-Alegria%2C+Claudio%3BMori%2C+Yasuo%3BBirnbaumer%2C+Lutz%3BArmstrong%2C+David+L&rft.aulast=Erxleben&rft.aufirst=Christian&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3932&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-17 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Physiol. 1986 Sep;378:31-51 [2432251] J Cell Biol. 2005 Nov 7;171(3):537-47 [16275756] Am J Physiol. 1990 Aug;259(2 Pt 2):H639-42 [2167026] Ann N Y Acad Sci. 1991;635:26-34 [1660238] Immunol Today. 1992 Apr;13(4):136-42 [1374612] J Gen Physiol. 1997 Nov;110(5):503-13 [9348323] J Biol Chem. 1998 Dec 25;273(52):34857-67 [9857013] Am J Physiol Cell Physiol. 2004 Dec;287(6):C1717-24 [15525689] Nat Neurosci. 2005 Jun;8(6):791-6 [15880107] J Clin Invest. 2005 Aug;115(8):1986-9 [16075038] J Gen Physiol. 2005 Sep;126(3):205-12 [16129771] Nat Cell Biol. 2000 Mar;2(3):173-7 [10707089] Curr Top Cell Regul. 2000;36:237-95 [10842755] Trends Cell Biol. 2000 Aug;10(8):322-8 [10884684] Annu Rev Cell Dev Biol. 2000;16:521-55 [11031246] Biochem J. 2000 Oct 1;351(Pt 1):95-105 [10998351] Science. 2001 Oct 12;294(5541):333-9 [11598293] J Physiol. 2002 Oct 1;544(Pt 1):57-69 [12356880] Biochemistry. 2002 Nov 26;41(47):14001-9 [12437357] Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2929-34 [12601159] J Neurosci. 2003 Nov 5;23(31):10116-21 [14602827] Mol Interv. 2004 Apr;4(2):97-107 [15087483] Trends Cardiovasc Med. 2004 May;14(4):152-61 [15177266] Cell. 2004 Oct 1;119(1):19-31 [15454078] J Neurosci. 2004 Sep 29;24(39):8391-3 [15456809] J Neurosci. 2004 Sep 29;24(39):8404-9 [15456812] Proc Natl Acad Sci U S A. 1984 Aug;81(15):4824-7 [6205402] Nature. 1984 Oct 11-17;311(5986):538-44 [6207437] J Mol Cell Cardiol. 1986 Jul;18(7):691-710 [2427730] J Neurosci. 2005 Oct 26;25(43):9883-92 [16251435] Biochem J. 1988 Nov 15;256(1):283-90 [2851982] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Observed Changes in Liver-Associated Enzymes During Long Term Inpatient Phase 1 Clinical Trials T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40139889; 4079179 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Cherstniakova, Svetlana Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - clinical trials KW - Enzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40139889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Observed+Changes+in+Liver-Associated+Enzymes+During+Long+Term+Inpatient+Phase+1+Clinical+Trials&rft.au=Cherstniakova%2C+Svetlana&rft.aulast=Cherstniakova&rft.aufirst=Svetlana&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges Encountered in Development of Anti-Obesity Drugs T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40139846; 4079166 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Staten, Myrlene Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40139846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Challenges+Encountered+in+Development+of+Anti-Obesity+Drugs&rft.au=Staten%2C+Myrlene&rft.aulast=Staten&rft.aufirst=Myrlene&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Cytochrome P450 3A4 (CYP3A4) by Vinblastine: Role of the Nuclear Receptor NR1I2 T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40116505; 4079226 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Smith, Nicola F Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Cytochrome P450 KW - Nuclear receptors KW - Vinblastine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Induction+of+Cytochrome+P450+3A4+%28CYP3A4%29+by+Vinblastine%3A+Role+of+the+Nuclear+Receptor+NR1I2&rft.au=Smith%2C+Nicola+F&rft.aulast=Smith&rft.aufirst=Nicola&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From a Policy Makers Perspective The Present and Future of the Race and Pharmacogenetics Debate in the Imminent Theranostics Age T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40066667; 4079229 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Arena, J Fernando Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Policies KW - Subpopulations KW - Races KW - Pharmacogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=From+a+Policy+Makers+Perspective+The+Present+and+Future+of+the+Race+and+Pharmacogenetics+Debate+in+the+Imminent+Theranostics+Age&rft.au=Arena%2C+J+Fernando&rft.aulast=Arena&rft.aufirst=J&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outlier Detection as a Spatial Data Mining Tool for National Cancer Surveillance T2 - 2006 Meeting of the Association of American Geographers AN - 39768601; 4082651 JF - 2006 Meeting of the Association of American Geographers AU - Stinchcomb, David AU - Pickle, Linda Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Cancer KW - Data processing KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+of+the+Association+of+American+Geographers&rft.atitle=Outlier+Detection+as+a+Spatial+Data+Mining+Tool+for+National+Cancer+Surveillance&rft.au=Stinchcomb%2C+David%3BPickle%2C+Linda&rft.aulast=Stinchcomb&rft.aufirst=David&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+of+the+Association+of+American+Geographers&rft.issn=&rft_id=info:doi/ L2 - http://communicate.aag.org/eseries/aag_org/program/index.cfm?mtgID=51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A milestone for hepatitis C virus research: A virus generated in cell culture is fully viable in vivo AN - 20198710; 6749234 JF - Proceedings of the National Academy of Sciences, USA AU - Bukh, Jens AU - Purcell, Robert H AD - Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3500 EP - 3501 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Hepatitis C virus KW - Cell culture KW - V 22410:Animal Diseases KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20198710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+milestone+for+hepatitis+C+virus+research%3A+A+virus+generated+in+cell+culture+is+fully+viable+in+vivo&rft.au=Bukh%2C+Jens%3BPurcell%2C+Robert+H&rft.aulast=Bukh&rft.aufirst=Jens&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3500&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell culture; Hepatitis C virus ER - TY - JOUR T1 - Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants AN - 17120761; 6749302 AB - Neurotrophic factors are agents with a promising ability to retard progression of neurodegenerative diseases and are effective in slowing photoreceptor degeneration in animal models of retinitis pigmentosa. Here we report a human clinical trial of a neurotrophic factor for retinal neurodegeneration. In this Phase I safety trial, human ciliary neurotrophic factor (CNTF) was delivered by cells transfected with the human CNTF gene and sequestered within capsules that were surgically implanted into the vitreous of the eye. The outer membrane of the encapsulated cell implant is semipermeable to allow CNTF to reach the retina. Ten participants received CNTF implants in one eye. When the implants were removed after 6 months, they contained viable cells with minimal cell loss and gave CNTF output at levels previously shown to be therapeutic for retinal degeneration in rcd1 dogs. Although the trial was not powered to form a judgment as to clinical efficacy, of seven eyes for which visual acuity could be tracked by conventional reading charts, three eyes reached and maintained improved acuities of 10-15 letters, equivalent to two- to three-line improvement on standard Snellen acuity charts. A surgically related choroidal detachment in one eye resulted in a transient acuity decrease that resolved with conservative management. This Phase I trial indicated that CNTF is safe for the human retina even with severely compromised photoreceptors. The approach to delivering therapeutic proteins to degenerating retinas using encapsulated cell implants may have application beyond disease caused by genetic mutations. JF - Proceedings of the National Academy of Sciences, USA AU - Sieving, Paul A AU - Caruso, Rafael C AU - Tao, Weng AU - Coleman, Hanna R AU - Thompson, Darby JS AU - Fullmer, Keri R AU - Bush, Ronald A AD - National Eye Institute and National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3896 EP - 3901 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; CSA Neurosciences Abstracts KW - retinal degeneration KW - Ciliary neurotrophic factor KW - Animal models KW - Acuity KW - Photoreceptors KW - Neurodegenerative diseases KW - Eye diseases KW - Retinitis pigmentosa KW - N3 11015:Visual systems (retinal and central) KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17120761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Ciliary+neurotrophic+factor+%28CNTF%29+for+human+retinal+degeneration%3A+Phase+I+trial+of+CNTF+delivered+by+encapsulated+cell+intraocular+implants&rft.au=Sieving%2C+Paul+A%3BCaruso%2C+Rafael+C%3BTao%2C+Weng%3BColeman%2C+Hanna+R%3BThompson%2C+Darby+JS%3BFullmer%2C+Keri+R%3BBush%2C+Ronald+A&rft.aulast=Sieving&rft.aufirst=Paul&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3896&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acuity; Eye diseases; Ciliary neurotrophic factor; retinal degeneration; Animal models; Photoreceptors; Retinitis pigmentosa; Neurodegenerative diseases ER - TY - JOUR T1 - Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial. AN - 67679617; 16256250 AB - HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines. JF - Vaccine AU - Deloria-Knoll, Maria AU - Steinhoff, Mark AU - Semba, Richard D AU - Nelson, Kenrad AU - Vlahov, David AU - Meinert, Curtis L AD - National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. mknoll@jhsph.edu Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 SP - 1670 EP - 1679 VL - 24 IS - 10 SN - 0264-410X, 0264-410X KW - Antibodies, Bacterial KW - 0 KW - Pneumococcal Vaccines KW - Vaccines, Conjugate KW - Vitamin A KW - 11103-57-4 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Vaccines, Conjugate -- immunology KW - Humans KW - Adult KW - Middle Aged KW - Dietary Supplements KW - Male KW - Immunization KW - Female KW - Zinc -- administration & dosage KW - Vitamin A -- blood KW - Pneumococcal Vaccines -- adverse effects KW - Vitamin A -- administration & dosage KW - Antibodies, Bacterial -- blood KW - Substance Abuse, Intravenous -- immunology KW - HIV Seropositivity -- immunology KW - Pneumococcal Vaccines -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Effect+of+zinc+and+vitamin+A+supplementation+on+antibody+responses+to+a+pneumococcal+conjugate+vaccine+in+HIV-positive+injection+drug+users%3A+a+randomized+trial.&rft.au=Deloria-Knoll%2C+Maria%3BSteinhoff%2C+Mark%3BSemba%2C+Richard+D%3BNelson%2C+Kenrad%3BVlahov%2C+David%3BMeinert%2C+Curtis+L&rft.aulast=Deloria-Knoll&rft.aufirst=Maria&rft.date=2006-03-06&rft.volume=24&rft.issue=10&rft.spage=1670&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-12 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Pdcd4 Targets eIF4A to Inhibit Translation, Transcription Tumorigenesis, and Invasion T2 - 2006 Keystone Symposia on Molecular Targets for Cancer Prevention (C7) AN - 40141332; 4098786 JF - 2006 Keystone Symposia on Molecular Targets for Cancer Prevention (C7) AU - Colburn, Nancy H Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Translation KW - Transcription KW - Tumorigenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Targets+for+Cancer+Prevention+%28C7%29&rft.atitle=Pdcd4+Targets+eIF4A+to+Inhibit+Translation%2C+Transcription+Tumorigenesis%2C+and+Invasion&rft.au=Colburn%2C+Nancy+H&rft.aulast=Colburn&rft.aufirst=Nancy&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Targets+for+Cancer+Prevention+%28C7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging of Cardiac Autonomic Involvement in Neurodegenerative Disorders T2 - Second Annual Update Symposium Series on Clinical Neurology and Neurophysiology AN - 39823640; 4084659 JF - Second Annual Update Symposium Series on Clinical Neurology and Neurophysiology AU - Goldstein, David S Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Neuroimaging KW - Neurodegenerative diseases KW - Heart KW - Autonomic nervous system KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Update+Symposium+Series+on+Clinical+Neurology+and+Neurophysiology&rft.atitle=Imaging+of+Cardiac+Autonomic+Involvement+in+Neurodegenerative+Disorders&rft.au=Goldstein%2C+David+S&rft.aulast=Goldstein&rft.aufirst=David&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Update+Symposium+Series+on+Clinical+Neurology+and+Neurophysiology&rft.issn=&rft_id=info:doi/ L2 - http://www.neurophysiology-symposium.com/program_neurology2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deducing Mammalian Genome Function by Multi-Species Comparative Sequencing T2 - 2006 Keystone Symposia on Systems Biology: Integrating Biology, Technology and Computation (C6) AN - 40085014; 4098771 JF - 2006 Keystone Symposia on Systems Biology: Integrating Biology, Technology and Computation (C6) AU - Green, Eric D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40085014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Systems+Biology%3A+Integrating+Biology%2C+Technology+and+Computation+%28C6%29&rft.atitle=Deducing+Mammalian+Genome+Function+by+Multi-Species+Comparative+Sequencing&rft.au=Green%2C+Eric+D&rft.aulast=Green&rft.aufirst=Eric&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Systems+Biology%3A+Integrating+Biology%2C+Technology+and+Computation+%28C6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=789 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Alterations in Immune System Pathways Following Exposure to Immunosuppressive Chemicals T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40003250; 4146179 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Patterson, R AU - Walker, N AU - White Jr, K AU - Brown, R AU - Musgrove, D AU - Harrison, S AU - Germolec, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Immune system KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Gene+Expression+Alterations+in+Immune+System+Pathways+Following+Exposure+to+Immunosuppressive+Chemicals&rft.au=Patterson%2C+R%3BWalker%2C+N%3BWhite+Jr%2C+K%3BBrown%2C+R%3BMusgrove%2C+D%3BHarrison%2C+S%3BGermolec%2C+D&rft.aulast=Patterson&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Resistance In Cadmium-Transformed Human Prostate Epithelial Cells. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40002722; 4146464 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Qu, W. AU - Ke, H. AU - Broderick, D AU - French, J E AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Epithelial cells KW - Prostate KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Apoptotic+Resistance+In+Cadmium-Transformed+Human+Prostate+Epithelial+Cells.&rft.au=Qu%2C+W.%3BKe%2C+H.%3BBroderick%2C+D%3BFrench%2C+J+E%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Qu&rft.aufirst=W.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40002571; 4146428 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Doerrer, N AU - Boobis, A AU - Bucher, J AU - Cohen, S AU - Jacobson Kram, D AU - MacDonald, J AU - Wolf, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cancer KW - Hazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Data-Based+Assessment+of+Alternative+Strategies+for+Identification+of+Potential+Human+Cancer+Hazards&rft.au=Doerrer%2C+N%3BBoobis%2C+A%3BBucher%2C+J%3BCohen%2C+S%3BJacobson+Kram%2C+D%3BMacDonald%2C+J%3BWolf%2C+D&rft.aulast=Doerrer&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-Specific Toxicity Reduction by Encapsulating Toxins in Nanoliposomes: A Theoretical Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39964166; 4146523 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Dimitrov, D AU - Sidorov, I A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Toxins KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Non-Specific+Toxicity+Reduction+by+Encapsulating+Toxins+in+Nanoliposomes%3A+A+Theoretical+Model&rft.au=Dimitrov%2C+D%3BSidorov%2C+I+A&rft.aulast=Dimitrov&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis of Hepatoprotective Zinc Exposure in Mice and Rats. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39961714; 4146463 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Liu, J AU - Boos, J AU - Zhang, W AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Zinc KW - Mice KW - Rats KW - Genomic analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genomic+Analysis+of+Hepatoprotective+Zinc+Exposure+in+Mice+and+Rats.&rft.au=Liu%2C+J%3BBoos%2C+J%3BZhang%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diet, Obesity and Chemical Carcinogenesis: Experimental Approaches. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39961323; 4146348 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Hursting, S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Diets KW - Obesity KW - Carcinogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Diet%2C+Obesity+and+Chemical+Carcinogenesis%3A+Experimental+Approaches.&rft.au=Hursting%2C+S&rft.aulast=Hursting&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Mitochondrial DNA and Telomerase in Toxic Oxidative Stress Responses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946836; 4144936 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Van Houten, B AU - Santos, J H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Stress KW - Oxidative stress KW - Mitochondrial DNA KW - Telomerase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Role+of+Mitochondrial+DNA+and+Telomerase+in+Toxic+Oxidative+Stress+Responses&rft.au=Van+Houten%2C+B%3BSantos%2C+J+H&rft.aulast=Van+Houten&rft.aufirst=B&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is There a Threshold Level for Alterations in Thyroid Hormone concentrations in the Production of Thyroid Tumors in F344/N Rats? T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946411; 4146097 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Travlos, G AU - Pearse, G AU - Betz, L AU - Hooth, M AU - Harvey, E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hormones KW - Rats KW - Thyroid hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Is+There+a+Threshold+Level+for+Alterations+in+Thyroid+Hormone+concentrations+in+the+Production+of+Thyroid+Tumors+in+F344%2FN+Rats%3F&rft.au=Travlos%2C+G%3BPearse%2C+G%3BBetz%2C+L%3BHooth%2C+M%3BHarvey%2C+E&rft.aulast=Travlos&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrasonic Analysis, A Tool for Early Detection of Cardiotoxic Lesions: Preliminary Findings T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946209; 4146453 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Dunnick, J AU - Rouse, D AU - Myers, P AU - Vanderklok, C AU - Nyska, A AU - Johnson, J AU - Horton, J AU - Lieuallen, W AU - Malarkey, D AU - Maronpot, R R AU - Johnson, K Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Ultrasonics KW - Lesions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Ultrasonic+Analysis%2C+A+Tool+for+Early+Detection+of+Cardiotoxic+Lesions%3A+Preliminary+Findings&rft.au=Dunnick%2C+J%3BRouse%2C+D%3BMyers%2C+P%3BVanderklok%2C+C%3BNyska%2C+A%3BJohnson%2C+J%3BHorton%2C+J%3BLieuallen%2C+W%3BMalarkey%2C+D%3BMaronpot%2C+R+R%3BJohnson%2C+K&rft.aulast=Dunnick&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on the Role of Metallothionein and Synuclein in Lead-Induced Inclusion Body Formation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39943888; 4146637 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Zuo, P AU - Qu, W. AU - Cooper, R AU - Goyer, R A AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lead KW - Inclusion bodies KW - Synuclein KW - Metallothionein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39943888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+on+the+Role+of+Metallothionein+and+Synuclein+in+Lead-Induced+Inclusion+Body+Formation&rft.au=Zuo%2C+P%3BQu%2C+W.%3BCooper%2C+R%3BGoyer%2C+R+A%3BWaalkes%2C+M+P&rft.aulast=Zuo&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of Nur77 and Cell Signaling Pathways in Tributyltin-Induced Apoptosis in Mouse Testicular Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39942640; 4146496 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lee, K AU - Jeong, H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Signal transduction KW - Apoptosis KW - Nur77 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Involvement+of+Nur77+and+Cell+Signaling+Pathways+in+Tributyltin-Induced+Apoptosis+in+Mouse+Testicular+Cells&rft.au=Lee%2C+K%3BJeong%2C+H&rft.aulast=Lee&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Whole Blood Carries Gene Expression Signatures Indicative of APAP-induced Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39935663; 4144587 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Heinloth, A N AU - Parker, J AU - Chou, J AU - Boorman, G AU - Irwin, R AU - Cunningham, M AU - Snell, M AU - Tennant, R AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Blood KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Whole+Blood+Carries+Gene+Expression+Signatures+Indicative+of+APAP-induced+Toxicity&rft.au=Heinloth%2C+A+N%3BParker%2C+J%3BChou%2C+J%3BBoorman%2C+G%3BIrwin%2C+R%3BCunningham%2C+M%3BSnell%2C+M%3BTennant%2C+R%3BPaules%2C+R+S&rft.aulast=Heinloth&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Oral and Dermal Toxicity of Tert-Butyl Hydroperoxide in Fischer 344 Rats and B6C3F1 Mice. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39935262; 4144513 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Aldridge, J AU - Doi, A AU - Ritchie, G D AU - Colleton, C A AU - Hejtmancik, M AU - Chhabra, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Mice KW - Rats KW - Skin KW - Tert-butyl hydroperoxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Oral+and+Dermal+Toxicity+of+Tert-Butyl+Hydroperoxide+in+Fischer+344+Rats+and+B6C3F1+Mice.&rft.au=Aldridge%2C+J%3BDoi%2C+A%3BRitchie%2C+G+D%3BColleton%2C+C+A%3BHejtmancik%2C+M%3BChhabra%2C+R&rft.aulast=Aldridge&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reference Substances for the Validation of in Vitro Ocular Toxicity Test Methods for the Evaluation of Ocular Corrosives and Severe Irritants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39934518; 4144856 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Allen, D AU - Blackard, B AU - Choksi, N AU - Truax, J AU - Tice, R AU - Stokes, W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Corrosion KW - Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reference+Substances+for+the+Validation+of+in+Vitro+Ocular+Toxicity+Test+Methods+for+the+Evaluation+of+Ocular+Corrosives+and+Severe+Irritants&rft.au=Allen%2C+D%3BBlackard%2C+B%3BChoksi%2C+N%3BTruax%2C+J%3BTice%2C+R%3BStokes%2C+W&rft.aulast=Allen&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Prion Transduces Neuroprotective Signals via PI3K/AKT Pathways T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39931428; 4144454 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lee, K J AU - Jeong, H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - 1-Phosphatidylinositol 3-kinase KW - Neuroprotection KW - Prion protein KW - AKT protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Cellular+Prion+Transduces+Neuroprotective+Signals+via+PI3K%2FAKT+Pathways&rft.au=Lee%2C+K+J%3BJeong%2C+H&rft.aulast=Lee&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39930064; 4145180 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Guo, G L AU - Moffit, J S AU - Nicol, C J AU - Ward, J M AU - Aleksunes, L A AU - Kliewer, S A AU - Manauto, J E AU - Gonzalez, F J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Pregnane X receptors KW - Acetaminophen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Enhanced+Acetaminophen+Toxicity+by+Activation+of+the+Pregnane+X+Receptor&rft.au=Guo%2C+G+L%3BMoffit%2C+J+S%3BNicol%2C+C+J%3BWard%2C+J+M%3BAleksunes%2C+L+A%3BKliewer%2C+S+A%3BManauto%2C+J+E%3BGonzalez%2C+F+J&rft.aulast=Guo&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relative Carcinogenic Potency of PCB 126 and PeCDF in Dermally Exposed Female Tg.AC Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39927201; 4146029 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Wyde, M E AU - Nyska, A AU - Vallant, M AU - Fomby, L M AU - Hejtmancik, M AU - Easterling, M AU - Bucher, J R AU - Walker, N J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Carcinogenicity KW - PCB KW - Polychlorinated biphenyls UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Relative+Carcinogenic+Potency+of+PCB+126+and+PeCDF+in+Dermally+Exposed+Female+Tg.AC+Mice&rft.au=Wyde%2C+M+E%3BNyska%2C+A%3BVallant%2C+M%3BFomby%2C+L+M%3BHejtmancik%2C+M%3BEasterling%2C+M%3BBucher%2C+J+R%3BWalker%2C+N+J&rft.aulast=Wyde&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alteration in Carcinogenic Potency of PCB126 by PCB153 Following Chronic Exposure in Female Rats. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39927153; 4146028 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Walker, N J AU - Wyde, M E AU - Easterling, M AU - Nyska, A AU - Portier, C R AU - Bucher, J R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Carcinogenicity KW - Rats KW - Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Alteration+in+Carcinogenic+Potency+of+PCB126+by+PCB153+Following+Chronic+Exposure+in+Female+Rats.&rft.au=Walker%2C+N+J%3BWyde%2C+M+E%3BEasterling%2C+M%3BNyska%2C+A%3BPortier%2C+C+R%3BBucher%2C+J+R&rft.aulast=Walker&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 14-Week Oral Toxicity Studies of Kava In F344 Rats: Immunohistochemical Analysis of Expressions of Hepatic Cytochrome P450 T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39918190; 4146260 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Clayton, N P AU - Yoshizawa, K AU - Kissling, G AU - Chan, P AU - Burka, L T AU - Nyska, A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cytochrome P450 KW - Toxicity KW - Rats KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=14-Week+Oral+Toxicity+Studies+of+Kava+In+F344+Rats%3A+Immunohistochemical+Analysis+of+Expressions+of+Hepatic+Cytochrome+P450&rft.au=Clayton%2C+N+P%3BYoshizawa%2C+K%3BKissling%2C+G%3BChan%2C+P%3BBurka%2C+L+T%3BNyska%2C+A&rft.aulast=Clayton&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on Blood Metallothionein as a Biomarker of Tissue Metallothionein Expression. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39917137; 4146477 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Shen, J AU - Liu, J AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Blood KW - Metallothionein KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+on+Blood+Metallothionein+as+a+Biomarker+of+Tissue+Metallothionein+Expression.&rft.au=Shen%2C+J%3BLiu%2C+J%3BWaalkes%2C+M+P&rft.aulast=Shen&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Epigenetics in the Fetal Basis of Adult Disease T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39912814; 4146708 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jirtle, R AU - Heindel, J J AU - Newbold, R AU - Archer, T k AU - Skinner, M AU - Walker, C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Fetuses KW - Epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Role+of+Epigenetics+in+the+Fetal+Basis+of+Adult+Disease&rft.au=Jirtle%2C+R%3BHeindel%2C+J+J%3BNewbold%2C+R%3BArcher%2C+T+k%3BSkinner%2C+M%3BWalker%2C+C&rft.aulast=Jirtle&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidation of a Gene Regulatory Network for Forebrain Development using Bioinformatics Approaches for the Analysis of Compiled Microarray Datasets T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910801; 4146366 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Gohlke, J M AU - Parham, F M AU - Parker, J S AU - Smith, M V AU - Portier, C J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Forebrain KW - Computer programs KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Elucidation+of+a+Gene+Regulatory+Network+for+Forebrain+Development+using+Bioinformatics+Approaches+for+the+Analysis+of+Compiled+Microarray+Datasets&rft.au=Gohlke%2C+J+M%3BParham%2C+F+M%3BParker%2C+J+S%3BSmith%2C+M+V%3BPortier%2C+C+J&rft.aulast=Gohlke&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility and Ozone Exacerbation of Allergic Asthma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910669; 4146342 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kleeberger, S R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Respiratory diseases KW - Ozone KW - Asthma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genetic+Susceptibility+and+Ozone+Exacerbation+of+Allergic+Asthma&rft.au=Kleeberger%2C+S+R&rft.aulast=Kleeberger&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility of the TRP53 Haploinsufficient Mouse to Radiation Induced Lymphoma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910017; 4144634 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - French, J E AU - Parron, V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lymphoma KW - Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genetic+Susceptibility+of+the+TRP53+Haploinsufficient+Mouse+to+Radiation+Induced+Lymphoma&rft.au=French%2C+J+E%3BParron%2C+V&rft.aulast=French&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hepatoprotective Interleukin-13 Diversely Affects Cytokines and Chemokines in Acetaminophen-Induced Murine Liver Disease T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39909816; 4144597 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Yee, S B AU - Bourdi, M AU - Pohl, L R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Liver diseases KW - Chemokines KW - Interleukin 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Hepatoprotective+Interleukin-13+Diversely+Affects+Cytokines+and+Chemokines+in+Acetaminophen-Induced+Murine+Liver+Disease&rft.au=Yee%2C+S+B%3BBourdi%2C+M%3BPohl%2C+L+R&rft.aulast=Yee&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reproducibility Analyses for In Vitro Neutral Red Uptake Methods from a Validation Study to Evaluate In Vitro Cytotoxicity Assays for Estimating Rodent Acute Systemic Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39909542; 4146410 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Paris, M AU - Strickland, J AU - Casati, S AU - Tice, R AU - Stokes, W AU - Raabe, H AU - Cao, C AU - Clothier, R AU - Clothier,J. AU - Mun, G AU - Sizemore, A AU - Moyer, G O AU - Madren-Whalley, J AU - Krishna, C AU - Owen, M AU - Bourne, N AU - Harvey,E. AU - Lee, R AU - Haseman, J AU - Crockett, P AU - Wenk, M AU - Vallant, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Cytotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reproducibility+Analyses+for+In+Vitro+Neutral+Red+Uptake+Methods+from+a+Validation+Study+to+Evaluate+In+Vitro+Cytotoxicity+Assays+for+Estimating+Rodent+Acute+Systemic+Toxicity&rft.au=Paris%2C+M%3BStrickland%2C+J%3BCasati%2C+S%3BTice%2C+R%3BStokes%2C+W%3BRaabe%2C+H%3BCao%2C+C%3BClothier%2C+R%3BClothier%2CJ.%3BMun%2C+G%3BSizemore%2C+A%3BMoyer%2C+G+O%3BMadren-Whalley%2C+J%3BKrishna%2C+C%3BOwen%2C+M%3BBourne%2C+N%3BHarvey%2CE.%3BLee%2C+R%3BHaseman%2C+J%3BCrockett%2C+P%3BWenk%2C+M%3BVallant%2C+M&rft.aulast=Paris&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Baseline Animal Microarray Database for Biological Response Identification and Biomarker Validation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39906595; 4144870 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Fostel, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Databases KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Baseline+Animal+Microarray+Database+for+Biological+Response+Identification+and+Biomarker+Validation&rft.au=Fostel%2C+J&rft.aulast=Fostel&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Relationship Between In Vivo Rabbit Eye Test Scores and their Reversibility T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39906564; 4144859 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tice, R R AU - Allen, D G AU - Choksi, N Y AU - Truax, J F AU - Stokes, W S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Eye UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Evaluation+of+the+Relationship+Between+In+Vivo+Rabbit+Eye+Test+Scores+and+their+Reversibility&rft.au=Tice%2C+R+R%3BAllen%2C+D+G%3BChoksi%2C+N+Y%3BTruax%2C+J+F%3BStokes%2C+W+S&rft.aulast=Tice&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of Magnetic Resonance Imaging in Developmental Neurotoxicity Testing: A Pilot Study T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39905331; 4145114 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Johnson, K AU - Ryan, L AU - Davis, J AU - Elmore, A AU - Guenther, B AU - Marcus, J AU - Maronpot, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Neurotoxicity KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Application+of+Magnetic+Resonance+Imaging+in+Developmental+Neurotoxicity+Testing%3A+A+Pilot+Study&rft.au=Johnson%2C+K%3BRyan%2C+L%3BDavis%2C+J%3BElmore%2C+A%3BGuenther%2C+B%3BMarcus%2C+J%3BMaronpot%2C+R+R&rft.aulast=Johnson&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mice Deficient in Cyclooxygenase-2 are More Susceptible than Wild-Types to Kainic Acid Excitotoxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39905060; 4144427 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Toscano, C D AU - Bosetti, F Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Excitotoxicity KW - Kainic acid KW - Cyclooxygenase-2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Mice+Deficient+in+Cyclooxygenase-2+are+More+Susceptible+than+Wild-Types+to+Kainic+Acid+Excitotoxicity&rft.au=Toscano%2C+C+D%3BBosetti%2C+F&rft.aulast=Toscano&rft.aufirst=C&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integration of Genomics with Traditional Toxicology T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39904007; 4145287 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Boorman, G Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Integration KW - Genomics KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39904007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Integration+of+Genomics+with+Traditional+Toxicology&rft.au=Boorman%2C+G&rft.aulast=Boorman&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fertilization Rate and Oocyte Quality is Adversely Affected Following Neonatal Exposure to the Phytoestrogen Genistein T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39903591; 4145718 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jefferson, W N AU - Padilla-Banks, E AU - Goulding, E H AU - Eddy, E M AU - Newbold, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Oocytes KW - Phytoestrogens KW - Genistein KW - Neonates KW - Fertilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Fertilization+Rate+and+Oocyte+Quality+is+Adversely+Affected+Following+Neonatal+Exposure+to+the+Phytoestrogen+Genistein&rft.au=Jefferson%2C+W+N%3BPadilla-Banks%2C+E%3BGoulding%2C+E+H%3BEddy%2C+E+M%3BNewbold%2C+R+R&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploiting Phenotypic Anchoring to Reveal Gene Expression Indicators of Incipient Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39902050; 4145966 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Gene expression KW - Anchoring KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Exploiting+Phenotypic+Anchoring+to+Reveal+Gene+Expression+Indicators+of+Incipient+Toxicity&rft.au=Paules%2C+R+S&rft.aulast=Paules&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicokinetic Profile of Batracylin in Beagle Dogs T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901966; 4145953 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jia, L AU - Tomaszewski, J E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Toxicokinetic+Profile+of+Batracylin+in+Beagle+Dogs&rft.au=Jia%2C+L%3BTomaszewski%2C+J+E&rft.aulast=Jia&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Differential Gene Expression in Blood and Liver of Lipopolysaccharide Treated Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901656; 4144879 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Fannin, R D AU - Auman, J T AU - Bruno, M E AU - Sieber, S O AU - Tucker, C J AU - Merrick, B A AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Blood KW - Liver KW - Rats KW - Gene expression KW - Lipopolysaccharides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparison+of+Differential+Gene+Expression+in+Blood+and+Liver+of+Lipopolysaccharide+Treated+Rats&rft.au=Fannin%2C+R+D%3BAuman%2C+J+T%3BBruno%2C+M+E%3BSieber%2C+S+O%3BTucker%2C+C+J%3BMerrick%2C+B+A%3BPaules%2C+R+S&rft.aulast=Fannin&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unique Execution of NO-Mediated Toxicity within Naive and NGF-Differentiated PC12 Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901273; 4144784 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Brynczka, C AU - Merrick, B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Pheochromocytoma cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Unique+Execution+of+NO-Mediated+Toxicity+within+Naive+and+NGF-Differentiated+PC12+Cells&rft.au=Brynczka%2C+C%3BMerrick%2C+B&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selection of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Non-Target Tissue T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39897998; 4144891 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Auman, J T AU - Chou, J AU - Gerrish, K AU - Huang, Q AU - Jayadev, S AU - Blanchard, K T AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hepatotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Selection+of+Genes+Implicated+in+Methapyrilene-Induced+Hepatotoxicity+by+Comparing+Differential+Gene+Expression+in+Target+and+Non-Target+Tissue&rft.au=Auman%2C+J+T%3BChou%2C+J%3BGerrish%2C+K%3BHuang%2C+Q%3BJayadev%2C+S%3BBlanchard%2C+K+T%3BPaules%2C+R+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Antiretroviral Zidovudine Alters the Cell Cycle and Induces Metabolic Resistance in Human Lymphoblastoid Cells Exposed Long-Term In Vitro T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39896601; 4145751 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Olivero, O AU - Ming, J M AU - Vazquez, I L AU - Robinson, E J AU - Poirier, M C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Antiretroviral agents KW - Cell cycle KW - Zidovudine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Antiretroviral+Zidovudine+Alters+the+Cell+Cycle+and+Induces+Metabolic+Resistance+in+Human+Lymphoblastoid+Cells+Exposed+Long-Term+In+Vitro&rft.au=Olivero%2C+O%3BMing%2C+J+M%3BVazquez%2C+I+L%3BRobinson%2C+E+J%3BPoirier%2C+M+C&rft.aulast=Olivero&rft.aufirst=O&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposure to Environmental Estrogens During Development is Associated with Obesity Later in Life T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39893288; 4144338 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Newbold, R AU - Padilla-Banks, E AU - Snyder, R AU - Jefferson, W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Obesity KW - Estrogens KW - Sex hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Exposure+to+Environmental+Estrogens+During+Development+is+Associated+with+Obesity+Later+in+Life&rft.au=Newbold%2C+R%3BPadilla-Banks%2C+E%3BSnyder%2C+R%3BJefferson%2C+W&rft.aulast=Newbold&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Arsenic with Human Prostate Progenitor Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39883281; 4145671 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tokar, E J AU - Qu, W. AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Arsenic KW - Prostate KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Interactions+of+Arsenic+with+Human+Prostate+Progenitor+Cells&rft.au=Tokar%2C+E+J%3BQu%2C+W.%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Tokar&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - WormTox: Toxicological Screening Tools Using the Nematode Caenorhabditis Elegans T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39871048; 4145317 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Boyd, W AU - McBride, S AU - Rice, J AU - Snyder, D AU - Freedman, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Screening KW - Nematoda KW - Caenorhabditis elegans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39871048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=WormTox%3A+Toxicological+Screening+Tools+Using+the+Nematode+Caenorhabditis+Elegans&rft.au=Boyd%2C+W%3BMcBride%2C+S%3BRice%2C+J%3BSnyder%2C+D%3BFreedman%2C+J&rft.aulast=Boyd&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Gene Expression Associated with Exposure to Environmental Toxicants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870821; 4144959 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Freedman, J H AU - Chen, M AU - Coughlan, S AU - Boyd, W A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicants KW - Gene expression KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Changes+in+Gene+Expression+Associated+with+Exposure+to+Environmental+Toxicants&rft.au=Freedman%2C+J+H%3BChen%2C+M%3BCoughlan%2C+S%3BBoyd%2C+W+A&rft.aulast=Freedman&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nuclear Receptor CAR Regulates Dio1 and Alters Thyroid Hormone Activity in Regenerating Liver T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870596; 4145185 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tien, E AU - Negishi, M AU - Matsui, K AU - Moore, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Liver KW - Hormones KW - Nuclear receptors KW - Thyroid hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Nuclear+Receptor+CAR+Regulates+Dio1+and+Alters+Thyroid+Hormone+Activity+in+Regenerating+Liver&rft.au=Tien%2C+E%3BNegishi%2C+M%3BMatsui%2C+K%3BMoore%2C+R&rft.aulast=Tien&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Urogenital Carcinogenesis in Female CD1 Mice Induced by In Utero Arsenic Exposure is Enhanced by Postnatal Diethylstilbestrol Treatment T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870473; 4145673 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Waalkes, M P AU - Liu, J AU - Ward, J M AU - Powell, D A AU - Diwan, B A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Mice KW - Arsenic KW - Carcinogenesis KW - Intrauterine exposure KW - Diethylstilbestrol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Urogenital+Carcinogenesis+in+Female+CD1+Mice+Induced+by+In+Utero+Arsenic+Exposure+is+Enhanced+by+Postnatal+Diethylstilbestrol+Treatment&rft.au=Waalkes%2C+M+P%3BLiu%2C+J%3BWard%2C+J+M%3BPowell%2C+D+A%3BDiwan%2C+B+A&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemangiosarcomas Induced in Mice By N-(4-Hydroxyphenyl) Retinamide T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870297; 4146422 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Crowell, J A AU - Goldenthal, E I Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Hemangiosarcomas+Induced+in+Mice+By+N-%284-Hydroxyphenyl%29+Retinamide&rft.au=Crowell%2C+J+A%3BGoldenthal%2C+E+I&rft.aulast=Crowell&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disposition of a Mixture of Polybrominated Diphenyl Ethers (PBDES) in Male F344 Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870094; 4145563 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lebetkin, E H AU - Sanders, J M AU - Chen, L AU - Creech, A C AU - Burka, L T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Polybrominated diphenyl ethers KW - Rats KW - Disposition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Disposition+of+a+Mixture+of+Polybrominated+Diphenyl+Ethers+%28PBDES%29+in+Male+F344+Rats&rft.au=Lebetkin%2C+E+H%3BSanders%2C+J+M%3BChen%2C+L%3BCreech%2C+A+C%3BBurka%2C+L+T&rft.aulast=Lebetkin&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered S-Adenosylmethionine Metabolism and Glutathione Production in the Early Stages of Chronic Arsenic Exposure in Human Prostate Epithelial Cells: Implications in Arsenic Adaptation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39869764; 4145672 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Coppin, J AU - Benbrahim-Tallaa, L AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Arsenic KW - Metabolism KW - Adaptations KW - Epithelial cells KW - Prostate KW - Glutathione KW - S-Adenosylmethionine KW - Coenzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Altered+S-Adenosylmethionine+Metabolism+and+Glutathione+Production+in+the+Early+Stages+of+Chronic+Arsenic+Exposure+in+Human+Prostate+Epithelial+Cells%3A+Implications+in+Arsenic+Adaptation&rft.au=Coppin%2C+J%3BBenbrahim-Tallaa%2C+L%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Coppin&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respiratory Tract Toxicity of Diacetyl in C57Bl/6 Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39860475; 4144813 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Morgan, D L AU - Flake, G AU - Kirby, P J AU - Burka, L T AU - Kleeberger, S R AU - Garantziotis, S AU - Germolec, D R AU - Palmer, S M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Mice KW - Respiratory tract KW - Diacetyl KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Respiratory+Tract+Toxicity+of+Diacetyl+in+C57Bl%2F6+Mice&rft.au=Morgan%2C+D+L%3BFlake%2C+G%3BKirby%2C+P+J%3BBurka%2C+L+T%3BKleeberger%2C+S+R%3BGarantziotis%2C+S%3BGermolec%2C+D+R%3BPalmer%2C+S+M&rft.aulast=Morgan&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulating the Genome with Chromatin and Epigenetic Changes T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39859686; 4146709 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Archer, T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Genomes KW - Chromatin KW - Epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Regulating+the+Genome+with+Chromatin+and+Epigenetic+Changes&rft.au=Archer%2C+T&rft.aulast=Archer&rft.aufirst=T&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequential Phosphorylation by Protein Kinase CK2 Regulates NRF2 Activation and Degradation: Potential Role in Arsenic-Induced Skin Carcinogenesis T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858650; 4145335 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Pi, J. AU - Diwan, B A AU - Qu, W. AU - Liu, J AU - Bai, Y AU - Fahl, W AU - Yamauchi, H AU - Collins, S AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Skin KW - Carcinogenesis KW - Casein kinase II KW - Phosphorylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Sequential+Phosphorylation+by+Protein+Kinase+CK2+Regulates+NRF2+Activation+and+Degradation%3A+Potential+Role+in+Arsenic-Induced+Skin+Carcinogenesis&rft.au=Pi%2C+J.%3BDiwan%2C+B+A%3BQu%2C+W.%3BLiu%2C+J%3BBai%2C+Y%3BFahl%2C+W%3BYamauchi%2C+H%3BCollins%2C+S%3BWaalkes%2C+M+P&rft.aulast=Pi&rft.aufirst=J.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Animal Use in Acute Systemic Toxicity Testing by Using In Vitro Cytotoxicity Assays for Estimating Starting Doses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858576; 4146408 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Strickland, J A AU - Paris, M W AU - Casati, S AU - Tice, R R AU - Stokes, W S AU - Lee, R AU - Harvey, E AU - Haseman, J AU - Raabe, H AU - Cao, C AU - Clothier, R AU - Mun, G AU - Sizemore, A AU - Moyer, G AU - Madren-Whalley, J AU - Krishna, C AU - Owen, M AU - Bourne, N AU - Wenk, N AU - Vallant, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cytotoxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reducing+Animal+Use+in+Acute+Systemic+Toxicity+Testing+by+Using+In+Vitro+Cytotoxicity+Assays+for+Estimating+Starting+Doses&rft.au=Strickland%2C+J+A%3BParis%2C+M+W%3BCasati%2C+S%3BTice%2C+R+R%3BStokes%2C+W+S%3BLee%2C+R%3BHarvey%2C+E%3BHaseman%2C+J%3BRaabe%2C+H%3BCao%2C+C%3BClothier%2C+R%3BMun%2C+G%3BSizemore%2C+A%3BMoyer%2C+G%3BMadren-Whalley%2C+J%3BKrishna%2C+C%3BOwen%2C+M%3BBourne%2C+N%3BWenk%2C+N%3BVallant%2C+M&rft.aulast=Strickland&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of the Mechanisms of Toxicity of Polybrominated Diphenyl Ethers (PBDES). T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858459; 4146371 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Sanders, J M AU - Chen, L AU - Lebetkin, E H AU - Cunningham, M L AU - Burka, L T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Polybrominated diphenyl ethers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+of+the+Mechanisms+of+Toxicity+of+Polybrominated+Diphenyl+Ethers+%28PBDES%29.&rft.au=Sanders%2C+J+M%3BChen%2C+L%3BLebetkin%2C+E+H%3BCunningham%2C+M+L%3BBurka%2C+L+T&rft.aulast=Sanders&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Pathology of Hemangiosarcoma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39854217; 4145982 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Malarkey, D E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39854217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Pathology+of+Hemangiosarcoma&rft.au=Malarkey%2C+D+E&rft.aulast=Malarkey&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Performance of Four in Vitro Test Methods for the Classification of Ocular Corrosives and Severe Irritants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39810126; 4144858 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Stokes, W S AU - Choksi, N Y AU - Allen, D G AU - Truax, J F AU - Tice, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Corrosion KW - Classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39810126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Performance+of+Four+in+Vitro+Test+Methods+for+the+Classification+of+Ocular+Corrosives+and+Severe+Irritants&rft.au=Stokes%2C+W+S%3BChoksi%2C+N+Y%3BAllen%2C+D+G%3BTruax%2C+J+F%3BTice%2C+R+R&rft.aulast=Stokes&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ozone-Induced Exacerbation of Response to Recombinant Cockroach Allergen in a TLR4-Deficient Mouse Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39809998; 4144803 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Backus, G S AU - Walker, C R AU - Kleeberger, S R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Allergens KW - Ozonation KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Ozone-Induced+Exacerbation+of+Response+to+Recombinant+Cockroach+Allergen+in+a+TLR4-Deficient+Mouse+Model&rft.au=Backus%2C+G+S%3BWalker%2C+C+R%3BKleeberger%2C+S+R&rft.aulast=Backus&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Toxicity of Indium Phosphide Particulate in B6C3F1 Mice After Oropharyngeal Aspiration T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39809716; 4144756 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kirby, P J AU - Shines1, C. J. AU - Price, H C AU - Taylor, G AU - Everitt, J AU - Hill, G AU - Morgan, D L Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Particulates KW - Indium KW - Mice KW - Lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Pulmonary+Toxicity+of+Indium+Phosphide+Particulate+in+B6C3F1+Mice+After+Oropharyngeal+Aspiration&rft.au=Kirby%2C+P+J%3BShines1%2C+C.+J.%3BPrice%2C+H+C%3BTaylor%2C+G%3BEveritt%2C+J%3BHill%2C+G%3BMorgan%2C+D+L&rft.aulast=Kirby&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of the Di-(2-Ethylhexyl)Phthalate (Dehp) Noael for Reproductive Development in the Rat: Importance of Retention Of Extra F1 Animals. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39807821; 4146611 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Foster, P M AU - Bishop, J AU - Chapin, R E AU - Kissling, G E AU - Wolfe, G W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Determination+of+the+Di-%282-Ethylhexyl%29Phthalate+%28Dehp%29+Noael+for+Reproductive+Development+in+the+Rat%3A+Importance+of+Retention+Of+Extra+F1+Animals.&rft.au=Foster%2C+P+M%3BBishop%2C+J%3BChapin%2C+R+E%3BKissling%2C+G+E%3BWolfe%2C+G+W&rft.aulast=Foster&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Over-Expression of Dnmt3B is Sufficient for Global and Gene Specific DNA Hypermethylation During Cadmium-Induced Malignant Transformation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39806628; 4146474 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Benbrahim-Tallaa, L AU - Coppin, J AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Transformation KW - Overexpression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Selective+Over-Expression+of+Dnmt3B+is+Sufficient+for+Global+and+Gene+Specific+DNA+Hypermethylation+During+Cadmium-Induced+Malignant+Transformation&rft.au=Benbrahim-Tallaa%2C+L%3BCoppin%2C+J%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of an In Vitro Screening Assays to Predict Human Sensitivity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39805146; 4146005 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tomaszewski, J E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39805146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Use+of+an+In+Vitro+Screening+Assays+to+Predict+Human+Sensitivity&rft.au=Tomaszewski%2C+J+E&rft.aulast=Tomaszewski&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - One-time General Consent for Research on Biological Samples AN - 57196111; 200609983 AB - Clinicians and clinical researchers routinely obtain human biological samples and store them for future research. Previously, samples were often stored and used without informed consent. Most investigators thought that the protections in place for research with human participants were not needed for research with human samples. Recent commentators recognise the importance of informed consent for research with biological samples, but they disagree about when it is required and what types of consent should be obtained. Some argue that people should provide consent for each new study, at the time the study is proposed. Others support prospective consent, but they endorse different sets of options regarding the storage of samples, which investigators can use the samples, and what types of research can be performed. This profusion of guidance has led to divergent practices, with one study finding that institutional review boards in the United States recommend "various consent options, all of which are different'. Such variation may undermine the scientific value of patients' contributed samples and greatly increase the costs of such research. Assessing whether people's views support one of the recommended options for consent could provide a solution to these problems. 1 Table, 32 References. P. Broxis JF - BMJ (British Medical Journal) AU - Wendler, David AD - Dept Clinical Bioethics, NIH Clinical Center, Bethesda, MD dwendler@nih.gov Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 SP - 544 EP - 547 PB - British Medical Association, BMJ Publishing Group, London UK VL - 332 IS - 7540 SN - 0959-535X, 0959-535X KW - Evaluative research KW - Consent KW - Biological materials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57196111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=One-time+General+Consent+for+Research+on+Biological+Samples&rft.au=Wendler%2C+David&rft.aulast=Wendler&rft.aufirst=David&rft.date=2006-03-04&rft.volume=332&rft.issue=7540&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.332.7540.544 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Biological materials; Evaluative research; Consent DO - http://dx.doi.org/10.1136/bmj.332.7540.544 ER - TY - CPAPER T1 - Psychiatric Disorders in a Palliative Care Unit T2 - 14th European Congress of Psychiatry AN - 39899240; 4166267 JF - 14th European Congress of Psychiatry AU - Muniz, P S AU - Campos, F C AU - Nardi, A E Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+European+Congress+of+Psychiatry&rft.atitle=Psychiatric+Disorders+in+a+Palliative+Care+Unit&rft.au=Muniz%2C+P+S%3BCampos%2C+F+C%3BNardi%2C+A+E&rft.aulast=Muniz&rft.aufirst=P&rft.date=2006-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+European+Congress+of+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aep2006/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Refractory Pain-Depression Syndrome Treated with Tianeptine T2 - 14th European Congress of Psychiatry AN - 39890258; 4165746 JF - 14th European Congress of Psychiatry AU - Muniz, P S AU - Nardi, A E Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 KW - Tianeptine KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39890258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+European+Congress+of+Psychiatry&rft.atitle=Refractory+Pain-Depression+Syndrome+Treated+with+Tianeptine&rft.au=Muniz%2C+P+S%3BNardi%2C+A+E&rft.aulast=Muniz&rft.aufirst=P&rft.date=2006-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+European+Congress+of+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aep2006/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. AN - 67691974; 16380375 AB - RecQ helicases are believed to function in repairing replication forks stalled by DNA damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of damaged DNA, thus permitting repair to occur. Since little is known regarding the effects of DNA damage on RecQ helicases, and because the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of damaged DNA associated with the replication fork, we examined the effects of specific bulky, covalent adducts at N(6) of deoxyadenosine (dA) or N(2) of deoxyguanosine (dG) on Werner (WRN) syndrome helicase activity. The adducts are derived from the optically active 7,8-diol 9,10-epoxide (DE) metabolites of the carcinogen benzo[a]pyrene (BaP). The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand. These adducts either occupy the minor groove without significant perturbation of DNA structure (trans adducts) or cause base displacement at the adduct site (cis adducts). In contrast, helicase activity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helical structure. This differs from our previous observation that intercalating dA adducts derived from benzo[c]phenanthrene (BcPh) DEs inhibit WRN activity in a strand- and stereospecific manner. Partial unwinding of the DNA helix at BaP DE-dA adduct sites may make such adducted DNAs more susceptible to the action of helicase than DNA containing the corresponding BcPh DE-dA adducts, which cause little or no destabilization of duplex DNA. The single-stranded DNA binding protein RPA, an auxiliary factor for WRN helicase, enabled the DNA unwinding enzyme to overcome inhibition by either the trans-R or cis-R BaP DE-dG adduct, suggesting that WRN and RPA may function together to unwind duplex DNA harboring specific covalent adducts that otherwise block WRN helicase acting alone. JF - The Journal of biological chemistry AU - Choudhary, Saba AU - Doherty, Kevin M AU - Handy, Christopher J AU - Sayer, Jane M AU - Yagi, Haruhiko AU - Jerina, Donald M AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health/DHHS, Baltimore, MD 21224, USA. Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 SP - 6000 EP - 6009 VL - 281 IS - 9 SN - 0021-9258, 0021-9258 KW - DNA Adducts KW - 0 KW - Deoxyadenosines KW - Dihydroxydihydrobenzopyrenes KW - Epoxy Compounds KW - Replication Protein A KW - DNA KW - 9007-49-2 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Molecular Structure KW - Animals KW - DNA Damage KW - DNA -- metabolism KW - Deoxyadenosines -- chemistry KW - Deoxyadenosines -- metabolism KW - Deoxyguanosine -- chemistry KW - Nucleic Acid Conformation KW - Deoxyguanosine -- metabolism KW - DNA -- chemistry KW - DNA Replication KW - DNA Helicases -- metabolism KW - DNA Helicases -- antagonists & inhibitors KW - Epoxy Compounds -- metabolism KW - Epoxy Compounds -- chemistry KW - Dihydroxydihydrobenzopyrenes -- chemistry KW - Replication Protein A -- metabolism KW - Dihydroxydihydrobenzopyrenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67691974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Inhibition+of+Werner+syndrome+helicase+activity+by+benzo%5Ba%5Dpyrene+diol+epoxide+adducts+can+be+overcome+by+replication+protein+A.&rft.au=Choudhary%2C+Saba%3BDoherty%2C+Kevin+M%3BHandy%2C+Christopher+J%3BSayer%2C+Jane+M%3BYagi%2C+Haruhiko%3BJerina%2C+Donald+M%3BBrosh%2C+Robert+M&rft.aulast=Choudhary&rft.aufirst=Saba&rft.date=2006-03-03&rft.volume=281&rft.issue=9&rft.spage=6000&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Role of Innate Immunity in Suppression of Allergic Inflammation by Ascaris Suum Antigens T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39952701; 4147729 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Boesen, A AU - Wetzel, B AU - Norris, H AU - Bundoc, V AU - Urban, J AU - Keane-Myers, A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Immunity KW - Inflammation KW - Antigens KW - Ascaris suum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=The+Role+of+Innate+Immunity+in+Suppression+of+Allergic+Inflammation+by+Ascaris+Suum+Antigens&rft.au=Boesen%2C+A%3BWetzel%2C+B%3BNorris%2C+H%3BBundoc%2C+V%3BUrban%2C+J%3BKeane-Myers%2C+A&rft.aulast=Boesen&rft.aufirst=A&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pilot Study of Omalizumab (anti-IgE) in Eosinophilic Gastroenteritis T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39952244; 4147802 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Foroughi, S AU - Mannon, P J AU - Bernardino, L B AU - Foster, B AU - Scott, L M AU - Metcalfe, D D AU - Prussin, C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Gastroenteritis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Pilot+Study+of+Omalizumab+%28anti-IgE%29+in+Eosinophilic+Gastroenteritis&rft.au=Foroughi%2C+S%3BMannon%2C+P+J%3BBernardino%2C+L+B%3BFoster%2C+B%3BScott%2C+L+M%3BMetcalfe%2C+D+D%3BPrussin%2C+C&rft.aulast=Foroughi&rft.aufirst=S&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoimmune Lymphoproliferative Syndrome Caused by Defects in Mitochondria-Mediated Apoptotic Pathways T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39939966; 4147234 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Oliveira, J B AU - Lenardo, M J AU - Fleisher, T A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mitochondria KW - Apoptosis KW - Defects KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39939966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Autoimmune+Lymphoproliferative+Syndrome+Caused+by+Defects+in+Mitochondria-Mediated+Apoptotic+Pathways&rft.au=Oliveira%2C+J+B%3BLenardo%2C+M+J%3BFleisher%2C+T+A&rft.aulast=Oliveira&rft.aufirst=J&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FceR1 and Toll-Like Receptors Mediate Synergistic Signals to Markedly Augment Production of Inflammatory Cytokines in Murine Mast Cells T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39926923; 4147742 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Qiao, H AU - Beaven, M A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mast cells KW - Cytokines KW - Inflammation KW - Toll-like receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=FceR1+and+Toll-Like+Receptors+Mediate+Synergistic+Signals+to+Markedly+Augment+Production+of+Inflammatory+Cytokines+in+Murine+Mast+Cells&rft.au=Qiao%2C+H%3BBeaven%2C+M+A&rft.aulast=Qiao&rft.aufirst=H&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Regulation of Normal and SLE Plasma Cells by DCC (Deleted in Colon Cancer) and its Ligand Netrin-1 T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39910295; 4146938 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Lugar, P L AU - Slota, R AU - Fischer, R T AU - Withers, D AU - Pisitkun, P AU - Lipsky, P E AU - Grammer, A C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Colon cancer KW - DCC protein KW - Plasma cells KW - Ligands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Functional+Regulation+of+Normal+and+SLE+Plasma+Cells+by+DCC+%28Deleted+in+Colon+Cancer%29+and+its+Ligand+Netrin-1&rft.au=Lugar%2C+P+L%3BSlota%2C+R%3BFischer%2C+R+T%3BWithers%2C+D%3BPisitkun%2C+P%3BLipsky%2C+P+E%3BGrammer%2C+A+C&rft.aulast=Lugar&rft.aufirst=P&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Pathogens and Asthma: A Potential Connection T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39878328; 4147275 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Arbes Jr, S J AU - Cohen, E A AU - Sever, M L AU - Zeldin, D C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Respiratory diseases KW - Asthma KW - Pathogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Oral+Pathogens+and+Asthma%3A+A+Potential+Connection&rft.au=Arbes+Jr%2C+S+J%3BCohen%2C+E+A%3BSever%2C+M+L%3BZeldin%2C+D+C&rft.aulast=Arbes+Jr&rft.aufirst=S&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serotonin Induces Mast Cell Adhesion and Chemotaxis through the 5-HT1A Receptor T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39877625; 4147123 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Kushnir-Sukhov, N M AU - Gilfillan, A M AU - Coleman, J W AU - Toth, M AU - Bruening, S AU - Metcalfe, D D Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mast cells KW - Serotonin S1 receptors KW - Chemotaxis KW - Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Serotonin+Induces+Mast+Cell+Adhesion+and+Chemotaxis+through+the+5-HT1A+Receptor&rft.au=Kushnir-Sukhov%2C+N+M%3BGilfillan%2C+A+M%3BColeman%2C+J+W%3BToth%2C+M%3BBruening%2C+S%3BMetcalfe%2C+D+D&rft.aulast=Kushnir-Sukhov&rft.aufirst=N&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cockroach Allergen Reduction by Extermination Alone in Low-Income, Urban Homes-A Randomized Control Trial T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39869363; 4146970 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Sever, M AU - Arbes Jr, S J AU - Gore, J C AU - Santangelo, R G AU - Vaughn, B AU - Mitchell, H AU - Schal, C AU - Zeldin, D C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Socio-economic aspects KW - Allergens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Cockroach+Allergen+Reduction+by+Extermination+Alone+in+Low-Income%2C+Urban+Homes-A+Randomized+Control+Trial&rft.au=Sever%2C+M%3BArbes+Jr%2C+S+J%3BGore%2C+J+C%3BSantangelo%2C+R+G%3BVaughn%2C+B%3BMitchell%2C+H%3BSchal%2C+C%3BZeldin%2C+D+C&rft.aulast=Sever&rft.aufirst=M&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lichenoid Drug Eruption Associated with TNF Inhibitors T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39860661; 4147663 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Wilson, T M AU - Louie, G H AU - Rapkiewicz, A V AU - Foster, B AU - Turner, M L AU - Goldbach-Mansky, R AU - Rabin, R L AU - Prussin, C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Eruptions KW - Drugs KW - Tumor necrosis factor KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Lichenoid+Drug+Eruption+Associated+with+TNF+Inhibitors&rft.au=Wilson%2C+T+M%3BLouie%2C+G+H%3BRapkiewicz%2C+A+V%3BFoster%2C+B%3BTurner%2C+M+L%3BGoldbach-Mansky%2C+R%3BRabin%2C+R+L%3BPrussin%2C+C&rft.aulast=Wilson&rft.aufirst=T&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology T2 - 2006 Hepatitis Single Topic Conference AN - 39826328; 4094899 JF - 2006 Hepatitis Single Topic Conference AU - Kleiner, David Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Pathology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Hepatitis+Single+Topic+Conference&rft.atitle=Pathology&rft.au=Kleiner%2C+David&rft.aulast=Kleiner&rft.aufirst=David&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Hepatitis+Single+Topic+Conference&rft.issn=&rft_id=info:doi/ L2 - https://www.aasld.org/eweb/DynamicPage.aspx?webcode=eventsummary&evt_key=3c f16fd0-9b53-4758-8e12-534336848c6c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genes for Diabetes and Obesity (NIDDK Pima Indian Study) T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40148628; 4157372 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Bogardus, Clifton Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Obesity KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40148628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Genes+for+Diabetes+and+Obesity+%28NIDDK+Pima+Indian+Study%29&rft.au=Bogardus%2C+Clifton&rft.aulast=Bogardus&rft.aufirst=Clifton&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subcutaneous and Visceral Adipose Tissue Compartments and Association with 21 Metabolic Risk Factors: The Framingham Heart Study T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40102549; 4157348 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Fox, Caroline S AU - Massaro, Joseph M AU - Hoffmann, Udo AU - Maurovich-Horvat, Pal AU - Vasan, Ramachandran S AU - Meigs, James B AU - O'Donnell, Christopher J Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Adipose tissue KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+Compartments+and+Association+with+21+Metabolic+Risk+Factors%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BMassaro%2C+Joseph+M%3BHoffmann%2C+Udo%3BMaurovich-Horvat%2C+Pal%3BVasan%2C+Ramachandran+S%3BMeigs%2C+James+B%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abdominal Aortic Calcium as a Risk Factor for Development of Intermittent Claudication: The Framingham Heart Study T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40099554; 4157607 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Levitzky, Yamini S AU - Cupples, L Adrienne AU - Murabito, Joanne M AU - Wilson, Peter W AU - Kiel, Douglas P AU - Kannel, William AU - O'Donnell, Christopher J Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Calcium KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Abdominal+Aortic+Calcium+as+a+Risk+Factor+for+Development+of+Intermittent+Claudication%3A+The+Framingham+Heart+Study&rft.au=Levitzky%2C+Yamini+S%3BCupples%2C+L+Adrienne%3BMurabito%2C+Joanne+M%3BWilson%2C+Peter+W%3BKiel%2C+Douglas+P%3BKannel%2C+William%3BO%27Donnell%2C+Christopher+J&rft.aulast=Levitzky&rft.aufirst=Yamini&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mass determination of major plasma proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry AN - 954577925; 13860372 AB - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) serves as a rapid and accurate means to determine masses of proteins independent of their shapes or interactions with other molecules. It provides one of the most fundamental characterizations of major plasma proteins. Purified proteins in saline or serum specimens were prepared for analysis by dilution, mixing with a solution of sinapinic acid, and drying on a target plate. Specimens were analyzed in a linear TOF mode with external calibration. Analyses of 24 purified plasma proteins showed predominance of singly charged ions with lesser amounts of dimer and doubly charged monomer, and provided measured masses for these proteins. A number of proteins, including albumin, transferrin, apolipoproteins A-I, A-II, C-I, C-II, and C-III, and prealbumin, could be analyzed directly in serum with appropriate dilution. Measured values for masses of major plasma proteins will assist in analysis of serum and plasma. It is possible to analyze a number of components by MALDI-TOF/MS directly in diluted serum. Extremely simple sample preparation techniques may be useful in analyzing structural variation of several major plasma proteins, particularly those with masses <30 kDa, including a number of apolipoproteins and markers of nutritional status or acute phase responses. JF - Clinical Proteomics AU - Hortin, Glen L AU - Remaley, Alan T AD - Department of Laboratory Medicine, National Institutes of Health, Building 10, Room 2C-407, 20892, Bethesda, MD, ghortin@mail.cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 103 EP - 115 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 2 IS - 1-2 SN - 1542-6416, 1542-6416 KW - Toxicology Abstracts KW - Nutritional status KW - Ions KW - Apolipoproteins KW - sinapinic acid KW - Drying KW - Apolipoprotein A-I KW - Mass spectroscopy KW - Monomers KW - Plasma proteins KW - Transferrin KW - Albumin KW - Lasers KW - proteomics KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954577925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Proteomics&rft.atitle=Mass+determination+of+major+plasma+proteins+by+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometry&rft.au=Hortin%2C+Glen+L%3BRemaley%2C+Alan+T&rft.aulast=Hortin&rft.aufirst=Glen&rft.date=2006-03-01&rft.volume=2&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Clinical+Proteomics&rft.issn=15426416&rft_id=info:doi/10.1385%2FCP%3A2%3A1%3A103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Nutritional status; Ions; Apolipoproteins; sinapinic acid; Drying; Apolipoprotein A-I; Mass spectroscopy; Plasma proteins; Monomers; Transferrin; Albumin; Lasers; proteomics DO - http://dx.doi.org/10.1385/CP:2:1:103 ER - TY - JOUR T1 - Evaluation of cell recycle on Thermomyces lanuginosus xylanase a production by Pichia pastoris GS 115 AN - 860392269; 13858393 AB - This work aims to evaluate cell recycle of a recombinant strain of Pichia pastoris GS115 on the Xylanase A (XynA) production of Thermomyces lanuginosus IOC-4145 in submerged fermentation. Fed-batch processes were carried out with methanol feeding at each 12h and recycling cell at 24, 48, and 72 h. Additionally, the influence of the initial cell concentration was investigated. XynA production was not decreased with the recycling time, during four cell recycles, using an initial cell concentration of 2.5 g/L. The maximum activity was 14,050 U/L obtained in 24h of expression. However, when the initial cell concentration of 0.25 g/L was investigated, the enzymatic activity was reduced by 30 and 75% after the third and fourth cycles, respectively. Finally, it could be concluded that the initial cell concentration influenced the process performance and the interval of cell recycle affected enzymatic production. JF - Applied Biochemistry and Biotechnology AU - Ferreira, Veronica AU - Nolasco, Patricia C AU - Castro, Aline M AU - Silva, Juliana NC AU - Santos, Alexandre S AU - Damaso, Monica CT AU - Pereira, Nei AD - Escola de Quimica-Universidade Federal do Rio de Janeiro, Caixa Postal 68542, CEP 21945-970, Rio de Janeiro, RJ, Brazil, nei@eq.ufri.br Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 226 EP - 233 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 129 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Feeding KW - Xylan endo-1,3-b-xylosidase KW - Fermentation KW - Methanol KW - Thermomyces lanuginosus KW - XynA protein KW - Enzymatic activity KW - Pichia pastoris KW - Recycling KW - Batch culture KW - Xylan endo-1,3- beta -xylosidase KW - K 03330:Biochemistry KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860392269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Evaluation+of+cell+recycle+on+Thermomyces+lanuginosus+xylanase+a+production+by+Pichia+pastoris+GS+115&rft.au=Ferreira%2C+Veronica%3BNolasco%2C+Patricia+C%3BCastro%2C+Aline+M%3BSilva%2C+Juliana+NC%3BSantos%2C+Alexandre+S%3BDamaso%2C+Monica+CT%3BPereira%2C+Nei&rft.aulast=Ferreira&rft.aufirst=Veronica&rft.date=2006-03-01&rft.volume=129&rft.issue=1-3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A129%3A1%3A226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Feeding; Xylan endo-1,3-b-xylosidase; Fermentation; Methanol; Enzymatic activity; XynA protein; Recycling; Xylan endo-1,3- beta -xylosidase; Batch culture; Thermomyces lanuginosus; Pichia pastoris DO - http://dx.doi.org/10.1385/ABAB:129:1:226 ER - TY - JOUR T1 - RSM analysis of the effects of the oxygen transfer coefficient and inoculum size on the xylitol production by Candida guilliermondii AN - 856760981; 13858396 AB - Biotechnology production of xylitol is an excellent alternative to the industrial chemical process for the production of this polyalcohol. In this work the behavior of Candida guilliermondii yeast was studied when crucial process variables were modified. The K sub(L)a (between 18 and 40/h) and the initial cell mass (between 4 and 10 g) were considered as control variables. A response surface methodology was applied to the experimental design to study the resulting effect when the control variables were modified. A regression model was developed and used to determine an optimal value that was further validated experimentally. The optimal values determined for K sub(L)a and X sub(0) were 32.85/h and 9.86 g, respectively, leading to maximum values for productivity (1.628 g/h) and xylitol yield (0.708 g/g). JF - Applied Biochemistry and Biotechnology AU - Vasquez, Mariana Penuela AU - Bezerra, Mauricio AU - Souza, Souza AU - Pereira, Nei AD - Departamento de Engenharia Bioquimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, CEP 21.949-900, Rio de Janeiro, RJ, Brasil, nei@eq.ufrj.br Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 256 EP - 264 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 129 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Oxygen KW - Xylitol KW - Inoculum KW - Regression analysis KW - Candida guilliermondii KW - K 03330:Biochemistry KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856760981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=RSM+analysis+of+the+effects+of+the+oxygen+transfer+coefficient+and+inoculum+size+on+the+xylitol+production+by+Candida+guilliermondii&rft.au=Vasquez%2C+Mariana+Penuela%3BBezerra%2C+Mauricio%3BSouza%2C+Souza%3BPereira%2C+Nei&rft.aulast=Vasquez&rft.aufirst=Mariana&rft.date=2006-03-01&rft.volume=129&rft.issue=1-3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A129%3A1%3A256 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Oxygen; Xylitol; Regression analysis; Inoculum; Candida guilliermondii DO - http://dx.doi.org/10.1385/ABAB:129:1:256 ER - TY - JOUR T1 - Placebo-controlled study of rTMS for the treatment of Parkinson's disease. AN - 85385719; pmid-16211618 AB - The objective of this study is to assess the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for gait and bradykinesia in patients with Parkinson's disease (PD). In a double-blind placebo-controlled study, we evaluated the effects of 25 Hz rTMS in 18 PD patients. Eight rTMS sessions were performed over a 4-week period. Four cortical targets (left and right motor and dorsolateral prefrontal cortex) were stimulated in each session, with 300 pulses each, 100% of motor threshold intensity. Left motor cortex (MC) excitability was assessed using motor evoked potentials (MEPs) from the abductor pollicis brevis. During the 4 weeks, times for executing walking and complex hand movements tests gradually decreased. The therapeutic rTMS effect lasted for at least 1 month after treatment ended. Right-hand bradykinesia improvement correlated with increased MEP amplitude evoked by left MC rTMS after individual sessions, but improvement overall did not correlate with MC excitability. rTMS sessions appear to have a cumulative benefit for improving gait, as well as reducing upper limb bradykinesia in PD patients. Although short-term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation.(c) 2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Lomarev, Mikhail P AU - Kanchana, Sulada AU - Bara-Jimenez, William AU - Iyer, Meena AU - Wassermann, Eric M AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA. lomarev@ninds.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 325 EP - 331 VL - 21 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Evoked Potentials, Motor: physiology KW - Female KW - Hand: physiopathology KW - Humans KW - Hypokinesia: physiopathology KW - Hypokinesia: therapy KW - Male KW - Middle Aged KW - Motor Cortex: physiopathology KW - Parkinson Disease: diagnosis KW - Parkinson Disease: physiopathology KW - *Parkinson Disease: therapy KW - Prefrontal Cortex: physiopathology KW - Severity of Illness Index KW - *Transcranial Magnetic Stimulation: instrumentation KW - Walking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Placebo-controlled+study+of+rTMS+for+the+treatment+of+Parkinson%27s+disease.&rft.au=Lomarev%2C+Mikhail+P%3BKanchana%2C+Sulada%3BBara-Jimenez%2C+William%3BIyer%2C+Meena%3BWassermann%2C+Eric+M%3BHallett%2C+Mark&rft.aulast=Lomarev&rft.aufirst=Mikhail&rft.date=2006-03-01&rft.volume=21&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth. AN - 85384012; pmid-16500445 AB - To analyze the therapeutic implications of the distribution of neck metastases (NM) in patients with squamous cell carcinoma (SCC) of the tongue and the floor of the mouth (FOM).From January 1987 through December 1997, 339 previously untreated patients with T1-2 N0 M0 SCC of the tongue and the FOM underwent primary surgical treatment in our institution. A retrospective review of the pathology reports and outcome of these patients was made to ascertain the prevalence and distribution of NM. Patients were grouped by clinical neck status at the time of neck dissection: elective neck dissection (END) in the NO neck and subsequent therapeutic dissection (STD) in the neck observed which converted clinically to N+ or regional recurrences after END. All patients were classified according to the American Joint Committee on Cancer (AJCC)/UICC 2002 TNM classification.All patients underwent surgical treatment of the primary cancer and had negative margins at frozen section. Overall incidence of NM was 41.3%. Twenty-seven point eight percent of T1 N0 M0 and 48.2% of T2 N0 M0 patients developed NM (P = .0004). Occult neck metastases occurred in 24.1% of patients. Clinically, N+ metastases occurred in 23.6% of patients. The overall incidence of NM in levels IV and V was 8.5%. Neck level IV nodes were involved in only 1.5% of patients in the END group versus 23.7% in the STD group (P < 0.001). Level V was always associated to nodal metastases in other neck levels. Only 2% of patients in our study presented "skip metastases" in the neck.Neck levels I and II were at great risk for the development of NM (46.9% and 75.3% respectively). Levels IV (6.5%) and V (2%) were rarely involved in our group of patients. The results found in this study support the indication of supraomohyoid neck dissection for N0 and a more comprehensive neck dissection (levels I-V) for N+ patients in Stage I-II SCC of the tongue and FOM. EBM rating: C-4. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Dias, Fernando L AU - Lima, Roberto A AU - Kligerman, Jacob AU - Farias, Terence P AU - Soares, Jose Roberto N AU - Manfro, Gabriel AU - Sa, Geraldo M AD - Department of Head and Neck Surgery, Brazilian National Cancer Institute, Av. Alexandre Ferreira 190, Rio de Janeiro, RJ 22470-220, Brazil. fdias@inca.gov.br Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 460 EP - 465 VL - 134 IS - 3 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Carcinoma, Squamous Cell: pathology KW - *Carcinoma, Squamous Cell: secondary KW - Follow-Up Studies KW - Humans KW - Lymph Nodes: pathology KW - *Lymphatic Metastasis: pathology KW - *Mouth Floor: pathology KW - *Mouth Neoplasms: pathology KW - Neck KW - Neck Dissection KW - Neoplasm Recurrence, Local: pathology KW - Neoplasm Staging KW - Retrospective Studies KW - Surgical Procedures, Elective KW - *Tongue Neoplasms: pathology KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85384012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Relevance+of+skip+metastases+for+squamous+cell+carcinoma+of+the+oral+tongue+and+the+floor+of+the+mouth.&rft.au=Dias%2C+Fernando+L%3BLima%2C+Roberto+A%3BKligerman%2C+Jacob%3BFarias%2C+Terence+P%3BSoares%2C+Jose+Roberto+N%3BManfro%2C+Gabriel%3BSa%2C+Geraldo+M&rft.aulast=Dias&rft.aufirst=Fernando&rft.date=2006-03-01&rft.volume=134&rft.issue=3&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Biosurfactant production by Rhodococcus erythropolis grown on glycerol as sole carbon source AN - 807290978; 13859271 AB - The production of biosurfactant by Rhodococcus erythropolis during the growth on glycerol was investigated. The process was carried out at 28C in a 1.5-L bioreactor using glycerol as carbon source. The bioprocess was monitored through measurements of biosurfactant concentration and glycerol consumption. After 51 h of cultivation, 1.7 g/L of biosurfactant, surface, and interfacial tensions values (with n-hexadecane) of 43 and 15 mN/m, respectively, 67% of Emulsifying Index (E sub(24)), and 94% of oil removal were obtained. The use of glycerol rather than what happens with hydrophobic carbon source allowed the release of the biosurfactant, originally associated to the cell wall. JF - Applied Biochemistry and Biotechnology AU - Ciapina, Elisa MP AU - Melo, Walber C AU - Santa Anna, Lidia MM AU - Santos, Alexandre S AU - Freire, Denise MG AU - Pereira, Nei AD - Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, CEP 21949-900, Rio de Janeiro, RJ, Brasil, nei@eq.ufrj.br Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 880 EP - 886 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 131 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts KW - Surface tension KW - biosurfactants KW - Hydrophobicity KW - Carbon sources KW - Oil KW - Growth KW - Carbon KW - Glycerol KW - Bioreactors KW - Rhodococcus erythropolis KW - Oil removal KW - Manganese KW - Biotechnology KW - Cell walls KW - Pollution control KW - Q1 08206:Physiology, biochemistry, biophysics KW - W 30950:Waste Treatment & Pollution Clean-up KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807290978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Biosurfactant+production+by+Rhodococcus+erythropolis+grown+on+glycerol+as+sole+carbon+source&rft.au=Ciapina%2C+Elisa+MP%3BMelo%2C+Walber+C%3BSanta+Anna%2C+Lidia+MM%3BSantos%2C+Alexandre+S%3BFreire%2C+Denise+MG%3BPereira%2C+Nei&rft.aulast=Ciapina&rft.aufirst=Elisa&rft.date=2006-03-01&rft.volume=131&rft.issue=1-3&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A131%3A1%3A880 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Growth; Surface tension; Glycerol; Carbon; Bioreactors; Oil removal; Biotechnology; Pollution control; Cell walls; Oil; Hydrophobicity; biosurfactants; Carbon sources; Manganese; Rhodococcus erythropolis DO - http://dx.doi.org/10.1385/ABAB:131:1:880 ER - TY - JOUR T1 - Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: Acute renal failure is dependent on MyD88 but not renal cell apoptosis AN - 807260170; 13631303 AB - Toll-like receptors (TLRs) are important in sepsis. Myeloid differentiation factor 88 (MyD88) is a key molecule involved in signal transduction by multiple TLRs. The objective of this study was to investigate the contribution of TLR4 and MyD88 to acute renal failure (ARF) induced by polymicrobial sepsis. Liver dysfunction and apoptosis in the spleen contribute to sepsis severity after cecal ligation and puncture (CLP). Therefore, we also investigated liver injury and splenic apoptosis. We used a mouse model of sepsis-induced ARF using CLP to generate polymicrobial sepsis. Despite fluid and antibiotic resuscitation the mice developed multi-organ failure, including ARF, which resembles human sepsis. We investigated the role of the TLR4 receptor by comparing C3H/HeJ mice (which lack TLR4) with C3H/He0UJ normal controls. The role of MyD88 was investigated by comparing MyD88 knockout mice (MyD88 super(-/-)) with wild-type controls. Following CLP, mice lacking TLR4 and wild-type mice both developed comparable ARF. However, MyD88 super(-/-) mice did not develop ARF compared to wild-type controls. In contrast, MyD88 super(-/-) mice developed liver injury comparable to wild type. After CLP, MyD88 super(-/-) mice had significantly reduced apoptosis in the spleen compared with wild type. Apoptosis was not detected in the kidney of wild-type or MyD88 super(-/-) mice after CLP. In summary, ARF induced by polymicrobial sepsis is dependent on MyD88, but not TLR4. The absence of MyD88 dissociates ARF from liver injury; liver injury is MyD88-independent. There was MyD88-dependent apoptosis in the spleen, but no apoptosis in the kidney. MyD88 may be a good drug target for some, but not all, organ dysfunctions following sepsis.Kidney International (2006) 69, 832-836. doi:10.1038/sj.ki.5000165; published online 11 January 2006 JF - Kidney International AU - Dear, J W AU - Yasuda, H AU - Hu, X AU - Hieny, S AU - Yuen, P S T AU - Hewitt, S M AU - Sher, A AU - Star, R A AD - 1 Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, Bethesda, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 832 EP - 836 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 69 IS - 5 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Apoptosis KW - Injuries KW - MyD88 protein KW - Kidney KW - Liver KW - Spleen KW - TLR4 protein KW - Toll-like receptors KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807260170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Sepsis-induced+organ+failure+is+mediated+by+different+pathways+in+the+kidney+and+liver%3A+Acute+renal+failure+is+dependent+on+MyD88+but+not+renal+cell+apoptosis&rft.au=Dear%2C+J+W%3BYasuda%2C+H%3BHu%2C+X%3BHieny%2C+S%3BYuen%2C+P+S+T%3BHewitt%2C+S+M%3BSher%2C+A%3BStar%2C+R+A&rft.aulast=Dear&rft.aufirst=J&rft.date=2006-03-01&rft.volume=69&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fsj.ki.5000165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sepsis; Apoptosis; Injuries; MyD88 protein; Liver; Kidney; Spleen; TLR4 protein; Toll-like receptors DO - http://dx.doi.org/10.1038/sj.ki.5000165 ER - TY - JOUR T1 - Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects. AN - 68921013; 17017365 JF - La Medicina del lavoro AU - Paules, R S AD - Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA. Paules@niehs.nih.gov PY - 2006 SP - 322 EP - 323 VL - 97 IS - 2 SN - 0025-7818, 0025-7818 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Noxae KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - United States KW - Gene Expression Profiling KW - Animals KW - Mutagenicity Tests KW - Liver -- drug effects KW - Humans KW - Liver -- metabolism KW - Organ Specificity KW - Rodentia KW - Acetaminophen -- toxicity KW - Noxae -- adverse effects KW - Noxae -- toxicity KW - Genomics -- methods KW - Biomarkers -- analysis KW - National Institutes of Health (U.S.) -- organization & administration KW - Toxicology -- methods KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68921013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=La+Medicina+del+lavoro&rft.atitle=Toxicogenomics+and+environmental+diseases%3A+the+search+for+biomarkers+predictive+of+adverse+effects.&rft.au=Paules%2C+R+S&rft.aulast=Paules&rft.aufirst=R&rft.date=2006-03-01&rft.volume=97&rft.issue=2&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=La+Medicina+del+lavoro&rft.issn=00257818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is occupational exposure to mineral oil a risk factor for rheumatoid arthritis? AN - 68784597; 16932671 JF - Nature clinical practice. Rheumatology AU - Miller, Frederick W AD - Environmental Autoimmunity Group, National Institutes of Health, DHHS, Clinical Research Center, Bethesda, MD 20892-1301, USA. millerf@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 130 EP - 131 VL - 2 IS - 3 SN - 1745-8382, 1745-8382 KW - Emollients KW - 0 KW - Citrulline KW - 29VT07BGDA KW - Mineral Oil KW - 8020-83-5 KW - Rheumatoid Factor KW - 9009-79-4 KW - Index Medicus KW - Rheumatoid Factor -- blood KW - Humans KW - Seroepidemiologic Studies KW - Aged KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Sweden -- epidemiology KW - Citrulline -- immunology KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Arthritis, Rheumatoid -- epidemiology KW - Occupational Diseases -- blood KW - Arthritis, Rheumatoid -- blood KW - Arthritis, Rheumatoid -- etiology KW - Occupational Diseases -- etiology KW - Mineral Oil -- adverse effects KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Emollients -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68784597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Rheumatology&rft.atitle=Is+occupational+exposure+to+mineral+oil+a+risk+factor+for+rheumatoid+arthritis%3F&rft.au=Miller%2C+Frederick+W&rft.aulast=Miller&rft.aufirst=Frederick&rft.date=2006-03-01&rft.volume=2&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Rheumatology&rft.issn=17458382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant treatment of high-risk adult soft tissue sarcomas: a survey by the Italian Sarcoma Group. AN - 68008789; 16724686 AB - After the first adjuvant study on adult soft tissue sarcomas was concluded, the participating institutions continued to select and treat patients according to that protocol. The aim of this study was to test the protocol reproducibility when applied as a standard practice. A call for retrospective data was launched in June 1999 (self-referral of consecutive unregistered patients); thereafter, a prospective follow-up was performed. The treatment regimen consisted of epirubicin (60 mg/m2 days 1 and 2), ifosfamide (3 g/m2/die for 3 days) and equimolar doses of 6-mercapto-ethansulfonate (MESNA), with 300 microg G-CSF administered subcutaneously from day +8 until recovery, every 3 weeks for a total of 5 cycles. From November 1996 to June 1999, 55 high-risk, adult patients were treated. The average median dose intensity was 89% of the planned program. Grade 3-4 toxicities were leukopenia (49%), thrombocytopenia (14%), transfusion requiring anemia in 7 patients (16%), and alopecia in all patients (100%). After a median follow-up of 70 months, 23 patients (41.8%) relapsed and 19 died. Median disease-free, local disease-free and overall survival rates have not yet been reached. The disease-free survival rates at 2 and 4 years were 73% and 57%, respectively; the corresponding overall survival rates were 91% and 70%, respectively. The feasibility and reproducibility of the original protocol were confirmed, since disease-specific overall survival and disease-free survival rates at the same period of observation and with the same prolonged follow-up did not differ. JF - Tumori AU - Frustaci, Sergio AU - Berretta, Massimiliano AU - Comandone, Alessandro AU - Bidoli, Ettore AU - De Paoli, Antonino AU - Gherlinzoni, Franco AU - De Pas, Tommaso AU - Barbieri, Enza AU - Pertici, Maurizio AU - Apice, Gaetano AU - Picci, Piero AU - Italian Sarcoma Group AD - Department of Medical Oncology, National Cancer Institute, Aviano. sfrustaci@cro.it ; Italian Sarcoma Group PY - 2006 SP - 92 EP - 97 VL - 92 IS - 2 SN - 0300-8916, 0300-8916 KW - Protective Agents KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Epirubicin KW - 3Z8479ZZ5X KW - Mesna KW - NR7O1405Q9 KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Humans KW - Aged KW - Italy KW - Risk Assessment KW - Feasibility Studies KW - Adult KW - Protective Agents -- therapeutic use KW - Treatment Outcome KW - Epirubicin -- administration & dosage KW - Adolescent KW - Chemotherapy, Adjuvant KW - Male KW - Survival Analysis KW - Alopecia -- chemically induced KW - Ifosfamide -- administration & dosage KW - Drug Administration Schedule KW - Granulocyte Colony-Stimulating Factor -- therapeutic use KW - Neoplasm Staging KW - Reproducibility of Results KW - Hematologic Diseases -- chemically induced KW - Prospective Studies KW - Risk Factors KW - Blood Transfusion KW - Follow-Up Studies KW - Middle Aged KW - Hematologic Diseases -- therapy KW - Female KW - Mesna -- therapeutic use KW - Sarcoma -- surgery KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Sarcoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68008789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tumori&rft.atitle=Adjuvant+treatment+of+high-risk+adult+soft+tissue+sarcomas%3A+a+survey+by+the+Italian+Sarcoma+Group.&rft.au=Frustaci%2C+Sergio%3BBerretta%2C+Massimiliano%3BComandone%2C+Alessandro%3BBidoli%2C+Ettore%3BDe+Paoli%2C+Antonino%3BGherlinzoni%2C+Franco%3BDe+Pas%2C+Tommaso%3BBarbieri%2C+Enza%3BPertici%2C+Maurizio%3BApice%2C+Gaetano%3BPicci%2C+Piero%3BItalian+Sarcoma+Group&rft.aulast=Frustaci&rft.aufirst=Sergio&rft.date=2006-03-01&rft.volume=92&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Tumori&rft.issn=03008916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ETS-TMPRSS2 fusion gene products in prostate cancer. AN - 67956878; 16575200 AB - Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlins et al. uses bioinformatics techniques to identify candidate oncogenic chromosomal changes based on analysis of outlier gene expression. The authors determined that two ETS transcription factors, ERG and ETV1 were outliers in prostate cancer. The group reports recurrent fusions of the 5' untranslated region of the TMPRSS2 gene to ERG and ETV1 in the majority of prostate cancer samples containing the outlier expression. In cell lines containing the fusion gene, androgen appears to play a role in mediating ETS overexpression. This fusion gene product may play an important role in the development, diagnosis, and treatment of prostate cancer. JF - Cancer biology & therapy AU - Ahlers, Christoph M AU - Figg, William D AD - Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 254 EP - 255 VL - 5 IS - 3 SN - 1538-4047, 1538-4047 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67956878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=ETS-TMPRSS2+fusion+gene+products+in+prostate+cancer.&rft.au=Ahlers%2C+Christoph+M%3BFigg%2C+William+D&rft.aulast=Ahlers&rft.aufirst=Christoph&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 67927165; 16649821 AB - To present nationally representative data on the prevalence, correlates, and comorbidity of DSM-IV panic disorder (PAN), including the differentiation between panic with agoraphobia (PDA) and without agoraphobia (PDWA) and agoraphobia without a history of panic disorder (AG). The data were derived from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093). Prevalence, correlates, and comorbidity of PAN, PDA, and PDWA with Axis I and II disorders were determined. Prevalences of 12-month and lifetime PAN were 2.1% and 5.1%. Rates of 12-month and lifetime PDWA were 1.6% and 4.0%, exceeding those of 12-month (0.6%) and lifetime (1.1%) PDA. Rates of 12-month and lifetime AG were extremely low, 0.05% and 0.17%. Being female, Native American, middle-aged, widowed/ separated/divorced, and of low income increased risk, while being Asian, Hispanic, or black decreased risk for PAN, PDA, and PDWA. Individuals with PDA were more likely to seek treatment and had earlier ages at onset and first treatment, longer episodes, and more severe disability, impairment, panic symptomatology, and Axis I and II comorbidity than those with PDWA. PDA may be a more severe variant of PAN. Overrepresentation of PDA in treatment settings reflects increased treatment seeking and the severity of PDA relative to PDWA. The very low prevalence of AG leaves open questions about the meaning of the disorder as a distinct clinical entity as defined in the DSM-IV. JF - The Journal of clinical psychiatry AU - Grant, Bridget F AU - Hasin, Deborah S AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Goldstein, Rise B AU - Smith, Sharon AU - Huang, Boji AU - Saha, Tulshi D AD - Laboratory of Epidemiology and Biometry, Division of Clinical and Biological Intramural Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. bgrant@wilco.niaaa.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 363 EP - 374 VL - 67 IS - 3 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Sex Factors KW - Age of Onset KW - Mental Disorders -- epidemiology KW - Humans KW - Aged KW - Indians, North American -- statistics & numerical data KW - Comorbidity KW - Ethnic Groups -- statistics & numerical data KW - Patient Acceptance of Health Care KW - Risk Factors KW - Adult KW - Health Surveys KW - Middle Aged KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Agoraphobia -- diagnosis KW - Panic Disorder -- epidemiology KW - Agoraphobia -- epidemiology KW - Panic Disorder -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67927165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=The+epidemiology+of+DSM-IV+panic+disorder+and+agoraphobia+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise+B%3BSmith%2C+Sharon%3BHuang%2C+Boji%3BSaha%2C+Tulshi+D&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2006-03-01&rft.volume=67&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Ment Health. 2006 Nov;9(4):114 [17065311] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic transformation and mechanism of action of mononitroso caffeidine- a new interpretation. AN - 67856672; 16611159 AB - Although caffeine is not carcinogenic, its hydrolysed product, caffeidine causes human cancer, possibly through endogenous nitrosation to form mononitroso caffeidine (MNC). MNC undergoes enzymatic demethylation and reacts with cellular nucleophiles, notably DNA, via the formation of a putative imidazole diazonium ion. Its interaction with proteins has not been reported. The present work is based on the hypothesis that some active metabolites of MNC covalently interact with cellular DNA and/or proteins to initiate carcinogenesis. We report here the synthesis of a possible reactive metabolite of MNC, viz., N, 1-methyl-4(N-methyl-N-nitrosamino)-imidazole-5-carboxylic acid (MNIC). Its structure has been determined by uv, ir, nmr and mass spectral analyses and its interaction with egg albumin and human serum protein has been examined by uv and CD spectroscopy. We concluded that metabolic activation of MNC occurs through the formation of MNIC. Avoiding consumption of salted tea or coffee that prevents the intake of caffeidine will possibly eliminate the risk of MNC carcinogenicity. JF - Endocrine, metabolic & immune disorders drug targets AU - Panda, G S AU - Bhattacharya, R K AU - Choudhuri, S K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P.Mukherjee Road, Calcutta-700 026, India. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1 EP - 6 VL - 6 IS - 1 SN - 1871-5303, 1871-5303 KW - Amino Acids KW - 0 KW - Anticarcinogenic Agents KW - Blood Proteins KW - Carcinogens KW - Coffee KW - Nitroimidazoles KW - Tea KW - 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone KW - 131134-91-3 KW - caffeidine KW - 20041-90-1 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Animals KW - Mass Spectrometry KW - Coffee -- chemistry KW - Humans KW - Spectrophotometry, Ultraviolet KW - Carcinogens -- toxicity KW - Blood Proteins -- chemistry KW - Circular Dichroism KW - Tea -- chemistry KW - Mice KW - Nitroimidazoles -- antagonists & inhibitors KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Spectrophotometry, Infrared KW - Amino Acids -- chemistry KW - Biotransformation KW - Nitroimidazoles -- toxicity KW - Male KW - Caffeine -- pharmacokinetics KW - Caffeine -- analogs & derivatives KW - Caffeine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67856672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine%2C+metabolic+%26+immune+disorders+drug+targets&rft.atitle=Metabolic+transformation+and+mechanism+of+action+of+mononitroso+caffeidine-+a+new+interpretation.&rft.au=Panda%2C+G+S%3BBhattacharya%2C+R+K%3BChoudhuri%2C+S+K&rft.aulast=Panda&rft.aufirst=G&rft.date=2006-03-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Endocrine%2C+metabolic+%26+immune+disorders+drug+targets&rft.issn=18715303&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-01 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris. AN - 67799192; 16450379 AB - Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are likely to cause osteolysis. Because multipotent mesenchymal stem cells (MSCs) located adjacent to the implant have an osteoprogenitor function and are critical contributors to osseous tissue integrity, when their functions or activities are compromised, osteolysis will most likely occur. To date, it is not certain or sufficiently confirmed whether MSCs endocytose titanium particles, and if so, whether particulate endocytosis has any effect on cellular responses to wear debris. This study seeks to clarify the phenomenon of titanium endocytosis by human MSCs (hMSCs), and investigates the influence of endocytosis on their activities. hMSCs incubated with commercially pure titanium particles exhibited internalized particles, as observed by scanning electron microscopy and confocal laser scanning microscopy, with time-dependent reduction in the number of extracellular particles. Particulate endocytosis was associated with reduced rates of cellular proliferation and cell-substrate adhesion, suppressed osteogenic differentiation, and increased rate of apoptosis. These cellular effects of exposure to titanium particles were reduced when endocytosis was inhibited by treatment with cytochalasin D, and no significant effect was seen when hMSCs were treated only with conditioned medium obtained from particulate-treated cells. These findings strongly suggest that the biological responses of hMSCs to wear debris are triggered primarily by the direct endocytosis of titanium particulates, and not mediated by secreted soluble factors. In this manner, therapeutical approaches that suppress particle endocytosis could reduce the bioreactivity of hMSCs to particulates, and enhance long-term orthopedic implant prognosis by minimizing wear-debris periprosthethic osteolysis. Copyright 2006 Orthopaedic Research Society. JF - Journal of orthopaedic research : official publication of the Orthopaedic Research Society AU - Okafor, Chukwuka C AU - Haleem-Smith, Hana AU - Laqueriere, Patrice AU - Manner, Paul A AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC8022, Department of Health and Human Services, Bethesda, Maryland 20892-8022, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 461 EP - 473 VL - 24 IS - 3 SN - 0736-0266, 0736-0266 KW - Cytochalasin D KW - 22144-77-0 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Osteolysis KW - Cell Proliferation -- drug effects KW - Microscopy, Confocal KW - Humans KW - Arthroplasty, Replacement -- methods KW - Cells, Cultured KW - Apoptosis -- drug effects KW - Arthroplasty, Replacement -- adverse effects KW - Cytochalasin D -- pharmacology KW - Osteogenesis -- drug effects KW - Cell Adhesion -- drug effects KW - Cell Differentiation -- drug effects KW - Arthroplasty, Replacement -- instrumentation KW - Mesenchymal Stromal Cells -- ultrastructure KW - Mesenchymal Stromal Cells -- drug effects KW - Titanium -- adverse effects KW - Joint Prosthesis -- adverse effects KW - Endocytosis -- drug effects KW - Titanium -- metabolism KW - Mesenchymal Stromal Cells -- metabolism KW - Endocytosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67799192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.atitle=Particulate+endocytosis+mediates+biological+responses+of+human+mesenchymal+stem+cells+to+titanium+wear+debris.&rft.au=Okafor%2C+Chukwuka+C%3BHaleem-Smith%2C+Hana%3BLaqueriere%2C+Patrice%3BManner%2C+Paul+A%3BTuan%2C+Rocky+S&rft.aulast=Okafor&rft.aufirst=Chukwuka&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.issn=07360266&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deliberate self-harm and childhood hyperactivity in junior high school students. AN - 67794381; 16447027 AB - The present study aimed to explore the status of deliberate self-harm (DSH) among junior high-school students, and investigate the relationship between DSH and substance use and childhood hyperactivity. Subjects were 239 boys (mean age = 14.16 years, SD = 0.67) and 238 girls (14.22, 0.68) from a junior high-school in Kanagawa, Japan. A self-reporting questionnaire consisting of original questions on self-cutting, self-hitting, and tobacco and alcohol use was employed with the Wender Utah Rating Scale (WURS) for assessing childhood hyperactivity. Overall, 8.00% and 27.70% of males and 9.30% and 12.20% of females reported self-cutting and self-hitting, respectively. Regarding substance use, 33.10% and 74.10% of males and 14.30% and 63.40% of females reported tobacco and alcohol use, respectively. Comparisons of WURS scores between those with and without experience of problematic behaviors revealed that with all problematic behaviors in both genders, scores of those with experience were significantly higher than those without (P < 0.01 except for self-cutting in females, P < 0.05). The present study indicated that DSH is an important problem, even among children as young as junior high-school age. An association between DSH and childhood hyperactivity was also suggested. JF - European child & adolescent psychiatry AU - Izutsu, Takashi AU - Shimotsu, Sakie AU - Matsumoto, Toshihiko AU - Okada, Takayuki AU - Kikuchi, Akiko AU - Kojimoto, Miwa AU - Noguchi, Hirofumi AU - Yoshikawa, Kazuo AD - Dept. of Forensic Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187, Japan. izutsu@gakushikai.jp Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 172 EP - 176 VL - 15 IS - 3 SN - 1018-8827, 1018-8827 KW - Index Medicus KW - Schools KW - Humans KW - Surveys and Questionnaires KW - Sex Distribution KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Attention Deficit Disorder with Hyperactivity -- epidemiology KW - Students -- statistics & numerical data KW - Self-Injurious Behavior -- epidemiology KW - Intention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67794381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+child+%26+adolescent+psychiatry&rft.atitle=Deliberate+self-harm+and+childhood+hyperactivity+in+junior+high+school+students.&rft.au=Izutsu%2C+Takashi%3BShimotsu%2C+Sakie%3BMatsumoto%2C+Toshihiko%3BOkada%2C+Takayuki%3BKikuchi%2C+Akiko%3BKojimoto%2C+Miwa%3BNoguchi%2C+Hirofumi%3BYoshikawa%2C+Kazuo&rft.aulast=Izutsu&rft.aufirst=Takashi&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=European+child+%26+adolescent+psychiatry&rft.issn=10188827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-27 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions. AN - 67775412; 16553875 AB - We previously reported that Chlamydia trachomatis expresses the genes encoding tryptophan synthase (trpBA) and the tryptophan repressor (trpR). Here we employ primer extension analysis to identify the transcriptional origins of both trpR and trpBA, allowing for the identification of the putative operator sequences for both trpR and trpBA. Moreover we demonstrate that native recombinant chlamydial TrpR binds to the predicted operator sequence upstream of trpR. A restriction endonuclease protection assay was designed and used to demonstrate that 5-fluorotryptophan was the only tryptophan analogue capable of activating binding of native recombinant chlamydial TrpR to its operator. Additionally, 5-fluorotryptophan was the only analogue that repressed expression of trpBA at a level analogous to L-tryptophan itself. Based on these findings, a mutant selection protocol was designed and a C. trachomatis isolate containing a frameshift mutation in trpR was isolated. This chlamydial mutant synthesizes a truncated TrpR protein that cannot regulate expression of trpBA and trpR in response to changes in tryptophan levels. These findings provide the first genetic proof that TrpR acts as a negative regulator of transcription in C. trachomatis. JF - Molecular microbiology AU - Carlson, John H AU - Wood, Heidi AU - Roshick, Christine AU - Caldwell, Harlan D AU - McClarty, Grant AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, MT 59840, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1678 EP - 1691 VL - 59 IS - 6 SN - 0950-382X, 0950-382X KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - Repressor Proteins KW - TRPR protein, E coli KW - 5-fluorotryptophan KW - 343-91-9 KW - Tryptophan KW - 8DUH1N11BX KW - Tryptophan Synthase KW - EC 4.2.1.20 KW - Index Medicus KW - Gene Expression -- drug effects KW - Tryptophan -- pharmacology KW - Tryptophan -- analogs & derivatives KW - Base Sequence KW - Molecular Sequence Data KW - DNA, Bacterial -- metabolism KW - Amino Acid Sequence KW - Tryptophan -- metabolism KW - Tryptophan Synthase -- genetics KW - Mutation KW - Mutagenesis KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- genetics KW - Chlamydia trachomatis -- metabolism KW - Operator Regions, Genetic KW - Repressor Proteins -- metabolism KW - Bacterial Proteins -- metabolism KW - Chlamydia trachomatis -- drug effects KW - Regulon -- genetics KW - Chlamydia trachomatis -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67775412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=In+vivo+and+in+vitro+studies+of+Chlamydia+trachomatis+TrpR%3ADNA+interactions.&rft.au=Carlson%2C+John+H%3BWood%2C+Heidi%3BRoshick%2C+Christine%3BCaldwell%2C+Harlan+D%3BMcClarty%2C+Grant&rft.aulast=Carlson&rft.aufirst=John&rft.date=2006-03-01&rft.volume=59&rft.issue=6&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1989 Jun 5;264(16):9149-54 [2656696] J Mol Biol. 1988 Aug 20;202(4):769-77 [3050131] J Infect Dis. 1991 May;163(5):1103-7 [1673464] Microbiol Rev. 1991 Mar;55(1):143-90 [2030670] J Bacteriol. 1991 Jun;173(11):3601-4 [1904443] J Bacteriol. 1991 Aug;173(16):4932-40 [1860812] Eur J Biochem. 1991 Dec 5;202(2):459-70 [1761046] J Bacteriol. 1992 Jan;174(1):331-5 [1530846] Prog Nucleic Acid Res Mol Biol. 1992;42:1-38 [1574585] Biochemistry. 1992 Jun 30;31(25):5925-36 [1610835] J Mol Biol. 1994 May 13;238(4):592-614 [8176748] J Biol Chem. 1996 Jun 28;271(26):15393-400 [8663065] FEMS Microbiol Lett. 1997 Jun 15;151(2):225-30 [9228757] Science. 1998 Oct 23;282(5389):754-9 [9784136] Hautarzt. 1955 Nov;6(11):494-6 [13294661] Antimicrob Agents Chemother. 2005 Jan;49(1):406-7 [15616321] Antimicrob Agents Chemother. 2005 Mar;49(3):903-7 [15728882] Antimicrob Agents Chemother. 2005 Mar;49(3):1120-6 [15728912] Antimicrob Agents Chemother. 2005 Jul;49(7):2865-73 [15980362] Annu Rev Genet. 2005;39:47-68 [16285852] J Bacteriol. 2000 Jan;182(1):1-8 [10613855] Infect Immun. 2000 Mar;68(3):1337-49 [10678946] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12170-5 [11027315] J Biol Chem. 2000 Dec 1;275(48):38111-9 [10984489] J Exp Med. 2001 Apr 16;193(8):935-42 [11304554] Mol Microbiol. 2001 May;40(4):1027-36 [11401709] J Bacteriol. 2001 Sep;183(18):5414-25 [11514527] J Biol Chem. 2002 Jul 26;277(30):26893-903 [12011099] Genome Biol. 2002 Aug 29;3(9):research0051 [12225590] J Bacteriol. 2002 Dec;184(23):6566-71 [12426345] Biochemistry. 2002 Dec 17;41(50):14866-78 [12475235] J Clin Invest. 2003 Jun;111(11):1757-69 [12782678] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8478-83 [12815105] Mol Microbiol. 2003 Sep;49(5):1347-59 [12940992] Antimicrob Agents Chemother. 2004 Apr;48(4):1347-9 [15047540] Mol Microbiol. 2004 May;52(3):903-16 [15101993] Mol Gen Mikrobiol Virusol. 2004;(3):3-7 [15354934] Antimicrob Agents Chemother. 2004 Oct;48(10):3989-95 [15388463] Biochem Biophys Res Commun. 1970 Apr 8;39(1):13-9 [4910032] Biochemistry. 1975 Jul;14(13):3035-40 [1096937] J Mol Biol. 1975 Feb 15;92(1):93-111 [1097702] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2351-5 [1088825] Cell. 1980 Jun;20(2):269-81 [6248238] Proc Natl Acad Sci U S A. 1980 Dec;77(12):7117-21 [7012834] J Mol Biol. 1980 Dec 5;144(2):133-42 [7014917] J Mol Biol. 1981 Jan 5;145(1):47-73 [6167722] J Biol Chem. 1987 Apr 5;262(10):4922-7 [3549712] Nature. 1988 Sep 22;335(6188):321-9 [3419502] Biochim Biophys Acta. 1990 Apr 6;1048(2-3):113-26 [2182120] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Haplotype-based association analysis in cohort and nested case-control studies. AN - 67752104; 16542226 AB - Genetic epidemiologic studies often collect genotype data at multiple loci within a genomic region of interest from a sample of unrelated individuals. One popular method for analyzing such data is to assess whether haplotypes, i.e., the arrangements of alleles along individual chromosomes, are associated with the disease phenotype or not. For many study subjects, however, the exact haplotype configuration on the pair of homologous chromosomes cannot be derived with certainty from the available locus-specific genotype data (phase ambiguity). In this article, we consider estimating haplotype-specific association parameters in the Cox proportional hazards model, using genotype, environmental exposure, and the disease endpoint data collected from cohort or nested case-control studies. We study alternative Expectation-Maximization algorithms for estimating haplotype frequencies from cohort and nested case-control studies. Based on a hazard function of the disease derived from the observed genotype data, we then propose a semiparametric method for joint estimation of relative-risk parameters and the cumulative baseline hazard function. The method is greatly simplified under a rare disease assumption, for which an asymptotic variance estimator is also proposed. The performance of the proposed estimators is assessed via simulation studies. An application of the proposed method is presented, using data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. JF - Biometrics AU - Chen, Jinbo AU - Chatterjee, Nilanjan AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, Maryland 20852, USA. chenjin@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 28 EP - 35 VL - 62 IS - 1 SN - 0006-341X, 0006-341X KW - Index Medicus KW - Genotype KW - Epidemiologic Studies KW - Risk Factors KW - Humans KW - Neoplasms -- epidemiology KW - Environmental Exposure KW - Algorithms KW - Genetic Predisposition to Disease -- epidemiology KW - Neoplasms -- genetics KW - Haplotypes KW - Cohort Studies KW - Case-Control Studies KW - Proportional Hazards Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67752104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Haplotype-based+association+analysis+in+cohort+and+nested+case-control+studies.&rft.au=Chen%2C+Jinbo%3BChatterjee%2C+Nilanjan&rft.aulast=Chen&rft.aufirst=Jinbo&rft.date=2006-03-01&rft.volume=62&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176). AN - 67751091; 16533780 AB - The increased expression of markers associated with a differentiated phenotype, such as P-glycoprotein (Pgp), follows treatment with histone deacetylase inhibitors. Because depsipeptide (FR901228, FK228, NSC630176) is a substrate for Pgp, up-regulation of the gene that encodes it, MDR1, would mean that depsipeptide induces its own mechanism of resistance. To examine the effect of depsipeptide on expression of ATP-binding cassette transporters associated with multidrug resistance, the kidney cancer cell lines 108, 121, 127, and 143 were treated with depsipeptide and evaluated by quantitative reverse transcription-PCR. Increased levels of MDR1 (1.3- to 6.3-fold) and ABCG2 (3.2- to 11.1-fold) but not MRP1 (0.9- to 1.3-fold) were observed. The induced Pgp transported the fluorescent substrates rhodamine 123, bisantrene, calcein-AM, BODIPY-vinblastine, and BODIPY-paclitaxel. In normal peripheral blood mononuclear cells (PBMC) and circulating tumor cells obtained from patients receiving depsipeptide, increased levels of histone H3 acetylation were found. We next examined MDR1 levels in normal and malignant PBMCs obtained from 15 patients enrolled in clinical trials with depsipeptide and detected up to a 6-fold increase in normal PBMCs and up to an 8-fold increase in circulating tumor cells after depsipeptide administration. In one patient with Sézary syndrome, increased MDR1 gene expression was accompanied by increased cell surface Pgp expression in circulating Sézary cells as determined by measurement of MRK-16 staining by flow cytometry. These studies suggest that depsipeptide induces its own mechanism of resistance and thus provide a basis for clinical trials evaluating depsipeptide in combination with a Pgp inhibitor. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Robey, Robert W AU - Zhan, Zhirong AU - Piekarz, Richard L AU - Kayastha, Ganesh L AU - Fojo, Tito AU - Bates, Susan E AD - Cancer Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute, Bethesda, Maryland 20892, USA. robeyr@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1547 EP - 1555 VL - 12 IS - 5 SN - 1078-0432, 1078-0432 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Antibiotics, Antineoplastic KW - Antimetabolites KW - Antineoplastic Agents KW - Depsipeptides KW - Histones KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - RNA, Messenger KW - Hippocalcin KW - 149223-81-4 KW - Doxorubicin KW - 80168379AG KW - romidepsin KW - CX3T89XQBK KW - Didanosine KW - K3GDH6OH08 KW - Paclitaxel KW - P88XT4IS4D KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Kidney Neoplasms -- drug therapy KW - Humans KW - Hippocalcin -- pharmacology KW - Paclitaxel -- pharmacology KW - Carcinoma, Renal Cell -- drug therapy KW - Drug Resistance, Neoplasm KW - RNA, Messenger -- genetics KW - Drug Resistance, Multiple KW - Antimetabolites -- pharmacology KW - Tumor Cells, Cultured KW - Doxorubicin -- pharmacology KW - Sezary Syndrome -- metabolism KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Neoplasm Proteins -- genetics KW - Flow Cytometry KW - Neoplasm Proteins -- metabolism KW - Neoplastic Cells, Circulating -- metabolism KW - Kidney -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Kidney -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Sezary Syndrome -- drug therapy KW - Acetylation KW - Carcinoma, Renal Cell -- metabolism KW - RNA, Messenger -- metabolism KW - Histones -- metabolism KW - Colonic Neoplasms -- drug therapy KW - Kidney Neoplasms -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Colonic Neoplasms -- metabolism KW - Antineoplastic Agents -- pharmacology KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Leukocytes, Mononuclear -- metabolism KW - Depsipeptides -- pharmacology KW - Didanosine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67751091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Increased+MDR1+expression+in+normal+and+malignant+peripheral+blood+mononuclear+cells+obtained+from+patients+receiving+depsipeptide+%28FR901228%2C+FK228%2C+NSC630176%29.&rft.au=Robey%2C+Robert+W%3BZhan%2C+Zhirong%3BPiekarz%2C+Richard+L%3BKayastha%2C+Ganesh+L%3BFojo%2C+Tito%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-03-01&rft.volume=12&rft.issue=5&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial. AN - 67748781; 16537707 AB - Pro- and anti-inflammatory cytokine genes may be important in the maintenance and progression of colorectal cancer. It is possible that single-nucleotide polymorphisms in inflammatory genes may play a role in chronic colonic inflammation and development of colorectal adenomas. Furthermore, common variants in cytokine genes may modify the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer. We examined the association between cytokine gene polymorphisms and risk of recurrent adenomas among 1,723 participants in the Polyp Prevention Trial. We used logistic regression to calculate odds ratios (OR) for the association between genotype, NSAID use, and risk of adenoma recurrence. Cytokine gene polymorphisms were not statistically significantly associated with risk of adenoma recurrence in our study. We observed statistically significant interactions between NSAID use, IL-10 -1082 G>A genotype, and risk of adenoma recurrence (P = 0.01) and multiple adenoma recurrence (P = 0.01). Carriers of the IL-10 -1082 G>A variant allele who were non-NSAID users had a statistically significant decreased risk of multiple adenoma recurrence (OR, 0.43; 95% confidence interval, 0.24-0.77) as well as a nonsignificant 30% decreased risk of any adenoma recurrence. In contrast, NSAID users who were carriers of the IL-10 -1082 G>A variant allele were at an increased risk of any adenoma recurrence (OR, 1.55; 95% confidence interval, 1.00-2.43). These findings suggest that individuals who are carriers of the IL-10 -1082 G>A variant allele may not benefit from the chemoprotective effect of NSAIDs on adenoma polyp recurrence. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Sansbury, Leah B AU - Bergen, Andrew W AU - Wanke, Kay L AU - Yu, Binbing AU - Caporaso, Neil E AU - Chatterjee, Nilanjan AU - Ratnasinghe, Luke AU - Schatzkin, Arthur AU - Lehman, Teresa A AU - Kalidindi, Aravind AU - Modali, Ramakrishna AU - Lanza, Elaine AD - Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Suite 702, 6116 Executive Boulevard, MSC 8235, Bethesda, MD 20892-8325, USA. sansburl@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 494 EP - 501 VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Biomarkers, Tumor KW - Cytokines KW - Index Medicus KW - Sensitivity and Specificity KW - Genetic Variation KW - Odds Ratio KW - Neoplasm Staging KW - Humans KW - Aged KW - Biopsy, Needle KW - Risk Assessment KW - Polymerase Chain Reaction KW - Colonoscopy KW - Survival Rate KW - Logistic Models KW - Biomarkers, Tumor -- analysis KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Male KW - Colorectal Neoplasms -- mortality KW - Cytokines -- drug effects KW - Cytokines -- genetics KW - Neoplasm Recurrence, Local -- epidemiology KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Polymorphism, Genetic KW - Adenomatous Polyps -- therapy KW - Adenomatous Polyps -- pathology KW - Cytokines -- metabolism KW - Neoplasm Recurrence, Local -- prevention & control KW - Adenomatous Polyps -- mortality KW - Colorectal Neoplasms -- pathology KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Colorectal Neoplasms -- therapy KW - Neoplasm Recurrence, Local -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67748781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Inflammatory+cytokine+gene+polymorphisms%2C+nonsteroidal+anti-inflammatory+drug+use%2C+and+risk+of+adenoma+polyp+recurrence+in+the+polyp+prevention+trial.&rft.au=Sansbury%2C+Leah+B%3BBergen%2C+Andrew+W%3BWanke%2C+Kay+L%3BYu%2C+Binbing%3BCaporaso%2C+Neil+E%3BChatterjee%2C+Nilanjan%3BRatnasinghe%2C+Luke%3BSchatzkin%2C+Arthur%3BLehman%2C+Teresa+A%3BKalidindi%2C+Aravind%3BModali%2C+Ramakrishna%3BLanza%2C+Elaine&rft.aulast=Sansbury&rft.aufirst=Leah&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. AN - 67748657; 16537713 AB - Nucleotide excision repair (NER) is critical for protecting against damage from carcinogens in tobacco smoke. We evaluated the influence of common genetic variation in the NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6). Our study population included 1,150 patients with transitional cell carcinoma of the urinary bladder and 1,149 control subjects from Spain. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, and smoking status. Subjects with the variant genotypes for SNPs in four of the seven genes evaluated had small increases in bladder cancer risk compared to subjects with the homozygous wild-type genotypes: RAD23B IVS5-15A>G (OR, 1.3; 95% CI, 1.1-1.5; P = 0.01), ERCC2 R156R (OR, 1.3; 95% CI, 1.1-1.6; P = 0.006), ERCC1 IVS5+33A>C (OR, 1.2; 95% CI, 1.0-1.5; P = 0.06; P(trend) = 0.04), and ERCC5 M254V (OR, 1.4; 95% CI, 1.0-2.0; P = 0.04). A global test for pathway effects indicated that genetic variation in NER characterized by the 22 SNPs analyzed in this study significantly predicts bladder cancer risk (P = 0.04). Pairwise comparisons suggested that carrying variants in two genes could result in substantial increases in risk. Classification tree analyses suggested the presence of subgroups of individuals defined by smoking and NER genotypes that could have substantial increases in risk. In conclusion, these findings provide support for the influence of genetic variation in NER on bladder cancer risk. A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - García-Closas, Montserrat AU - Malats, Núria AU - Real, Francisco X AU - Welch, Robert AU - Kogevinas, Manolis AU - Chatterjee, Nilanjan AU - Pfeiffer, Ruth AU - Silverman, Debra AU - Dosemeci, Mustafa AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - Chanock, Stephen AU - Yeager, Meredith AU - Rothman, Nathaniel AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852-7234, USA. montse@nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 536 EP - 542 VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - DNA excision repair protein ERCC-5 KW - 0 KW - DNA-Binding Proteins KW - Genetic Markers KW - Nuclear Proteins KW - RAD23B protein, human KW - Transcription Factors KW - RAD23A protein, human KW - 156533-33-4 KW - ERCC1 protein, human KW - EC 3.1.- KW - Endonucleases KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Sensitivity and Specificity KW - Reference Values KW - Odds Ratio KW - Humans KW - Retrospective Studies KW - Prognosis KW - Aged KW - Risk Assessment KW - Age Distribution KW - Gene Expression Regulation, Neoplastic KW - Aged, 80 and over KW - Adult KW - Case-Control Studies KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Spain -- epidemiology KW - Sex Distribution KW - Male KW - Female KW - Survival Analysis KW - Urinary Bladder Neoplasms -- pathology KW - Nuclear Proteins -- genetics KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - DNA-Binding Proteins -- genetics KW - Genetic Variation -- genetics KW - Genetic Predisposition to Disease -- epidemiology KW - Endonucleases -- genetics KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67748657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Genetic+variation+in+the+nucleotide+excision+repair+pathway+and+bladder+cancer+risk.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BMalats%2C+N%C3%BAria%3BReal%2C+Francisco+X%3BWelch%2C+Robert%3BKogevinas%2C+Manolis%3BChatterjee%2C+Nilanjan%3BPfeiffer%2C+Ruth%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BRothman%2C+Nathaniel&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. AN - 67747168; 16533763 AB - The deleted in liver cancer-1 (DLC-1) gene that encodes a Rho GTPase-activating protein with tumor suppressor function is located on chromosome 8p21-22, a region frequently deleted in prostate carcinomas. This study was designed to determine whether DLC-1 is deregulated in prostate carcinomas and to assess the contribution of DLC-1 alterations to prostate carcinogenesis. Primary prostate carcinomas, prostate carcinoma cell lines, benign prostatic hyperplasias, and normal prostatic tissues were examined for detection of functional and structural alterations of the DLC-1 gene by real-time PCR, methylation-specific PCR, and Southern and Western blots. Down-regulation or loss of DCL-1 mRNA expression was detected in 10 of 27 (37%) prostate carcinomas, 3 of 5 (60%) prostate carcinoma cell lines, and 5 of 21 (24%) benign prostatic hyperplasias. DLC-1 promoter methylation was identified in 13 of 27 (48%) prostate carcinomas and 2 matching normal tissues and in 15 of 21 (71%) benign prostatic hyperplasias but was absent in 10 normal prostatic tissues from noncancerous individuals. Genomic deletions were found in only 3 prostate carcinomas and 1 benign prostatic hyperplasia. DLC-1 protein was not detected in 8 of 27 (30%) prostate carcinomas and 11 of 21 (52%) benign prostatic hyperplasias. Methylation of DLC-1 correlated with age in prostate carcinoma patients (P = 0.006) and with prostate-specific antigen blood levels in benign prostatic hyperplasia patients (P = 0.029). Treatment of the three prostate carcinoma cell lines (PC-3, LNCaP, and 22Rv1) expressing a low level of DLC-1 transcripts with inhibitors of DNA methyltransferase or histone deacetylase increased DLC-1 expression. These results show that the transcriptional silencing of DLC-1 by two epigenetic mechanisms is common and may be involved in the pathogenesis of prostate carcinomas and benign prostatic hyperplasias and could have potential clinical application in the early detection and gene therapy of prostate cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Guan, Ming AU - Zhou, Xiaoling AU - Soulitzis, Nikolaos AU - Spandidos, Demetrios A AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4262, USA. Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1412 EP - 1419 VL - 12 IS - 5 SN - 1078-0432, 1078-0432 KW - DLC1 protein, human KW - 0 KW - Enzyme Inhibitors KW - GTPase-Activating Proteins KW - RNA, Messenger KW - Tumor Suppressor Proteins KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Humans KW - Aged KW - RNA, Messenger -- genetics KW - Tumor Cells, Cultured KW - Down-Regulation KW - Blotting, Southern KW - Aged, 80 and over KW - Adult KW - Chromatin Immunoprecipitation KW - Molecular Sequence Data KW - Prostatic Hyperplasia -- metabolism KW - Promoter Regions, Genetic -- genetics KW - Prostatic Hyperplasia -- pathology KW - Male KW - Prostate -- metabolism KW - Acetylation KW - Blotting, Western KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Middle Aged KW - Prostatic Hyperplasia -- genetics KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - DNA Methylation KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Prostatic Neoplasms -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67747168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Aberrant+methylation+and+deacetylation+of+deleted+in+liver+cancer-1+gene+in+prostate+cancer%3A+potential+clinical+applications.&rft.au=Guan%2C+Ming%3BZhou%2C+Xiaoling%3BSoulitzis%2C+Nikolaos%3BSpandidos%2C+Demetrios+A%3BPopescu%2C+Nicholas+C&rft.aulast=Guan&rft.aufirst=Ming&rft.date=2006-03-01&rft.volume=12&rft.issue=5&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines. AN - 67738301; 16531823 AB - Efforts to develop effective cancer vaccines often use combinations of immunogenic peptides to increase the applicability and effectiveness of the immunizations. The immunologic consequences of combining more than 1 self/tumor antigen in a single vaccine emulsion remain unclear, however. We performed 2 sequential clinical trials in patients at high risk for melanoma recurrence. Patients were given the highly immunogenic gp100:209-217(210M) peptide and the less immunogenic tyrosinase:368-376(370D) peptide once every 3 weeks for 4 weeks. This vaccination course was 12 weeks long, and patients were vaccinated for up to 4 courses (16 total vaccinations). In the first trial in 31 patients, the peptides were emulsified separately in incomplete Freund adjuvant and injected at 2 different sites. In the second trial in 33 patients, the peptides were emulsified together and injected at the same site. Cryopreserved lymphocytes were obtained by apheresis after each course and were evaluated for antipeptide activity using tetramer, enzyme-linked immunospot, and in vitro sensitization boost assays. When the peptides were injected at separate sites, robust specific reactivity to the native gp100:209-217 peptide was measured by each of the assays, whereas immunization with the tyrosinase:368-376(370D) peptide was far less effective. When the peptides were emulsified and injected together at the same site, immunization to the gp100:209-217(210M) epitope dropped precipitously, whereas reactivity to the tyrosinase:368-376(370D) peptide was enhanced. These cautionary data indicate that mixing peptides in the same emulsion can alter reactivity compared with peptides injected separately by mechanisms that may include the induction of localized nonspecific inflammation or competitive binding of peptides to major histocompatibility complex molecules. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Rosenberg, Steven A AU - Sherry, Richard M AU - Morton, Kathleen E AU - Yang, James C AU - Topalian, Suzanne L AU - Royal, Richard E AU - Kammula, Udai S AU - Restifo, Nicholas P AU - Hughes, Marybeth S AU - Schwarz, Susan L AU - Ngo, Lien T AU - Mavroukakis, Sharon A AU - White, Donald E AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. SAR@nih.gov PY - 2006 SP - 224 EP - 231 VL - 29 IS - 2 SN - 1524-9557, 1524-9557 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Membrane Glycoproteins KW - PMEL protein, human KW - gp100 Melanoma Antigen KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Index Medicus KW - Monophenol Monooxygenase -- immunology KW - Monophenol Monooxygenase -- administration & dosage KW - Humans KW - Aged KW - Monophenol Monooxygenase -- chemistry KW - Antigens, Neoplasm -- administration & dosage KW - Drug Interactions -- immunology KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Antigens, Neoplasm -- immunology KW - Secondary Prevention KW - Female KW - Male KW - Cancer Vaccines -- administration & dosage KW - Cancer Vaccines -- immunology KW - Melanoma -- pathology KW - Melanoma -- therapy KW - Melanoma -- immunology KW - Membrane Glycoproteins -- immunology KW - Membrane Glycoproteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67738301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Altered+CD8%28%2B%29+T-cell+responses+when+immunizing+with+multiepitope+peptide+vaccines.&rft.au=Rosenberg%2C+Steven+A%3BSherry%2C+Richard+M%3BMorton%2C+Kathleen+E%3BYang%2C+James+C%3BTopalian%2C+Suzanne+L%3BRoyal%2C+Richard+E%3BKammula%2C+Udai+S%3BRestifo%2C+Nicholas+P%3BHughes%2C+Marybeth+S%3BSchwarz%2C+Susan+L%3BNgo%2C+Lien+T%3BMavroukakis%2C+Sharon+A%3BWhite%2C+Donald+E&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2006-03-01&rft.volume=29&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2001 Oct;7(10):3012-24 [11595689] J Immunother. 2001 Jul-Aug;24(4):363-73 [11565838] J Clin Oncol. 2003 Apr 15;21(8):1562-73 [12697882] J Clin Oncol. 2003 Jun 15;21(12):2415-32 [12805342] Cancer Immun. 2003 Oct 28;3:15 [14580186] J Clin Oncol. 2003 Nov 1;21(21):4016-26 [14581425] Cancer Invest. 2003;21(6):873-86 [14735692] J Immunol. 2004 Apr 1;172(7):4575-82 [15034075] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 1996 Feb 1;183(2):527-34 [8627164] J Immunol. 1996 Sep 15;157(6):2539-48 [8805655] J Immunol. 1998 Feb 15;160(4):1750-8 [9469433] Nat Med. 1998 Mar;4(3):321-7 [9500606] Annu Rev Immunol. 1999;17:51-88 [10358753] J Immunother. 2004 Nov-Dec;27(6):425-31 [15534486] J Immunol. 2005 Nov 1;175(9):6169-76 [16237114] Clin Cancer Res. 1999 Oct;5(10):2756-65 [10537339] Cancer Res. 1999 Dec 15;59(24):6230-8 [10626817] J Immunother. 2000 Mar-Apr;23(2):275-81 [10746554] Nature. 2001 May 17;411(6835):380-4 [11357146] Clin Cancer Res. 2002 May;8(5):967-72 [12006508] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. AN - 67737351; 16530703 AB - MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer. JF - Cancer cell AU - Yanaihara, Nozomu AU - Caplen, Natasha AU - Bowman, Elise AU - Seike, Masahiro AU - Kumamoto, Kensuke AU - Yi, Ming AU - Stephens, Robert M AU - Okamoto, Aikou AU - Yokota, Jun AU - Tanaka, Tadao AU - Calin, George Adrian AU - Liu, Chang-Gong AU - Croce, Carlo M AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 189 EP - 198 VL - 9 IS - 3 SN - 1535-6108, 1535-6108 KW - Biomarkers, Tumor KW - 0 KW - MicroRNAs KW - Index Medicus KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Aged KW - Middle Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Female KW - Survival Analysis KW - Biomarkers, Tumor -- genetics KW - Adenocarcinoma -- mortality KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- mortality KW - Adenocarcinoma -- genetics KW - MicroRNAs -- analysis KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67737351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+cell&rft.atitle=Unique+microRNA+molecular+profiles+in+lung+cancer+diagnosis+and+prognosis.&rft.au=Yanaihara%2C+Nozomu%3BCaplen%2C+Natasha%3BBowman%2C+Elise%3BSeike%2C+Masahiro%3BKumamoto%2C+Kensuke%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BOkamoto%2C+Aikou%3BYokota%2C+Jun%3BTanaka%2C+Tadao%3BCalin%2C+George+Adrian%3BLiu%2C+Chang-Gong%3BCroce%2C+Carlo+M%3BHarris%2C+Curtis+C&rft.aulast=Yanaihara&rft.aufirst=Nozomu&rft.date=2006-03-01&rft.volume=9&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Cancer+cell&rft.issn=15356108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Chem. 2013 Dec;59(12):1811-2 [23462030] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. AN - 67736831; 16531821 AB - CD4(+)CD25(+) T-regulatory cells (T(reg)) can inhibit the proliferation and cytokine secretion of CD4(+)CD25(-) helper T cells in mice and humans. In murine tumor models, the presence of these T(reg) cells can inhibit the antitumor effectiveness of T-cell transfer and active immunization approaches. We have thus initiated efforts to eliminate T(reg) cells selectively from human peripheral blood mononuclear cells (PBMCs) to potentially bolster antitumor responses. LMB-2 is a recombinant immunotoxin that is a fusion of a single-chain Fv fragment of the anti-Tac anti-CD25 monoclonal antibody to a truncated form of the bacterial Pseudomonas exotoxin A. In vitro incubation of human PBMCs with LMB-2 reduced the levels of CD4(+)CD25(+) and Foxp3-expressing cells without impairing the function of the remaining lymphocytes. The short in vivo half-life of LMB-2 makes it an attractive candidate for reducing human T(reg) cells in vivo before the administration of cancer vaccine or cell transfer immunotherapy approaches. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Attia, Peter AU - Powell, Daniel J AU - Maker, Ajay V AU - Kreitman, Robert J AU - Pastan, Ira AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. PY - 2006 SP - 208 EP - 214 VL - 29 IS - 2 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD4 KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Cancer Vaccines KW - Exotoxins KW - Immunotoxins KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Exotoxins -- administration & dosage KW - Humans KW - Immunotherapy KW - Mice KW - Exotoxins -- immunology KW - Antigens, CD4 -- immunology KW - Cell Death -- immunology KW - Receptors, Interleukin-2 -- immunology KW - Cells, Cultured KW - Recombinant Proteins -- immunology KW - Lymphocyte Depletion -- methods KW - Recombinant Proteins -- administration & dosage KW - Immunotoxins -- immunology KW - Immunotoxins -- administration & dosage KW - T-Lymphocytes, Regulatory -- pathology KW - Antibodies, Monoclonal -- administration & dosage KW - T-Lymphocytes, Regulatory -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67736831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Selective+elimination+of+human+regulatory+T+lymphocytes+in+vitro+with+the+recombinant+immunotoxin+LMB-2.&rft.au=Attia%2C+Peter%3BPowell%2C+Daniel+J%3BMaker%2C+Ajay+V%3BKreitman%2C+Robert+J%3BPastan%2C+Ira%3BRosenberg%2C+Steven+A&rft.aulast=Attia&rft.aufirst=Peter&rft.date=2006-03-01&rft.volume=29&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1999 Nov 15;94(10):3340-8 [10552943] J Immunother. 2005 Nov-Dec;28(6):582-92 [16224276] Nat Genet. 2001 Jan;27(1):20-1 [11137993] Cancer Res. 2002 Jul 15;62(14):3914-9 [12124318] Science. 2002 Oct 25;298(5594):850-4 [12242449] J Immunother. 2003 Jan-Feb;26(1):85-93 [12514432] Curr Opin Mol Ther. 2003 Feb;5(1):44-51 [12669470] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] J Leukoc Biol. 2003 Dec;74(6):961-5 [12960253] Immunity. 2004 Jan;20(1):107-18 [14738769] Novartis Found Symp. 2004;256:149-52; discussion 152-7, 259-69 [15027488] Annu Rev Immunol. 2004;22:531-62 [15032588] J Immunol. 2004 Jul 15;173(2):1444-53 [15240741] Expert Opin Biol Ther. 2004 Jul;4(7):1115-28 [15268678] Nat Med. 2004 Sep;10(9):942-9 [15322536] Blood. 1988 Nov;72(5):1805-16 [2846094] Nature. 1989 Jun 1;339(6223):394-7 [2498664] Proc Natl Acad Sci U S A. 1989 Dec;86(23):9485-8 [2594781] Transplantation. 1990 Jan;49(1):198-201 [2301012] Eur J Immunol. 1990 Apr;20(4):785-91 [2140788] Blood. 1993 Sep 15;82(6):1701-12 [8400227] Blood. 1994 Jan 15;83(2):426-34 [8286741] Bioconjug Chem. 1993 Nov-Dec;4(6):581-5 [8305530] Bioconjug Chem. 1993 Mar-Apr;4(2):112-20 [7873642] Transplant Proc. 1998 Aug;30(5):2155-8 [9723424] Immunity. 1999 Mar;10(3):281-7 [10204484] J Immunol. 1999 Aug 1;163(3):1690-5 [10415076] J Immunother. 2005 Mar-Apr;28(2):120-8 [15725955] J Immunol. 2005 Mar 1;174(5):2591-601 [15728465] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] J Immunother. 2005 Jul-Aug;28(4):403-11 [16000960] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment and management of chronic hepatitis B. AN - 67735212; 16527649 AB - An understanding of the natural history of CHB is critical for the management of the liver disease. Three clinical patterns with different clinical outcomes are recognized: HBeAg-positive CHB, HBeAg-negative CHB,and inactive CHB. Patients with elevated aminotransferase levels and HBV DNA greater than 105 viral copies per mL in serum and with features of chronic hepatitis on liver biopsy are candidates for therapy regardless of HBeAg status. Multiple host and viral factors and safety profiles of current therapies need to be considered carefully before recommending therapy. There appears to be no role for HBV genotyping in the management of patients. Three antiviral agents are approved for use against CHB infection:IFN-a, lamivudine, and adefovir. Efficacy is moderate at best and is limited by the poor tolerability of IFN and the development of resistance, coupled with concerns regarding the long-term safety with nucleoside analogs. Several new nucleoside and nucleotide analogs and novel agents are at various stages of development as potential therapies for CHB. The ideal compound would be one that is active against all replicative intermediates of the virus and has a low toxicity profile. Despite current shortcomings, the future of therapy for HBV is promising, as newer therapeutic options are being developed based on an understanding of the HBV life cycle. JF - Infectious disease clinics of North America AU - Ghany, Marc G AU - Doo, Edward C AD - Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-06, 10 Center Drive, MSC 1800, Bethesda, MD 29892-1800, USA. marcg@bldg10.niddk.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 63 EP - 79 VL - 20 IS - 1 SN - 0891-5520, 0891-5520 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67735212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disease+clinics+of+North+America&rft.atitle=Assessment+and+management+of+chronic+hepatitis+B.&rft.au=Ghany%2C+Marc+G%3BDoo%2C+Edward+C&rft.aulast=Ghany&rft.aufirst=Marc&rft.date=2006-03-01&rft.volume=20&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Infectious+disease+clinics+of+North+America&rft.issn=08915520&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2006-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint Of: Gastroenterol Clin North Am. 2004 Sep;33(3):563-79, ix [15324944] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors. AN - 67729245; 16522397 AB - Vasoactive intestinal peptide (VIP)-related peptides prevented the learning deficit in the offspring in a model for fetal alcohol syndrome. We evaluated whether the mechanism of the peptide protection included NR2B, NR2A, and GABAAalpha5. Timed, pregnant C57BL6/J mice were injected on gestational day 8 with alcohol (0.03 mL/kg), placebo, or alcohol plus peptides. Embryos were harvested after 6 hours, 24 hours, and on gestational day 18. Some of the litters were allowed to deliver, and the adult brains harvested after the offspring were tested for learning. Calibrator-normalized relative real-time polymerase chain reaction (PCR) was performed using primers for NR2B, NR2A, and GABAAalpha5 with GAPDH standardization. Statistic: analysis of variance (ANOVA) and Fisher PLSD, P < .05 was considered significant. In the embryo, the peptides prevented NR2B rise (P < .001) at 6 hours, NR2B down-regulation (P = .002), and GABAAalpha5 decrease (P < .01) on gestational day 18. In the adult, the peptides prevented NR2B down-regulation (P = .01) and NR2A up-regulation (P < .001). VIP-related peptides prevented alcohol-induced changes in NR2B, NR2A, and GABAAalpha5. This may explain, at least in part, the peptides' prevention of alcohol-induced learning deficits. JF - American journal of obstetrics and gynecology AU - Toso, Laura AU - Poggi, Sarah H AU - Roberson, Robin AU - Woodard, Jade AU - Park, Jane AU - Abebe, Daniel AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD 20892-0925, USA. laura_toso@hotmail.com Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 681 EP - 686 VL - 194 IS - 3 KW - Gabra5 protein, mouse KW - 0 KW - NR2A NMDA receptor KW - NR2B NMDA receptor KW - Oligopeptides KW - Protein Subunits KW - Receptors, GABA-A KW - Receptors, N-Methyl-D-Aspartate KW - activity-dependent neurotrophic factor KW - davunetide KW - GF00K3IIWE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Pregnancy KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, GABA-A -- physiology KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Oligopeptides -- therapeutic use KW - Receptors, GABA-A -- drug effects KW - Fetal Alcohol Spectrum Disorders KW - Learning Disorders -- etiology KW - Learning Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Prevention+of+alcohol-induced+learning+deficits+in+fetal+alcohol+syndrome+mediated+through+NMDA+and+GABA+receptors.&rft.au=Toso%2C+Laura%3BPoggi%2C+Sarah+H%3BRoberson%2C+Robin%3BWoodard%2C+Jade%3BPark%2C+Jane%3BAbebe%2C+Daniel%3BSpong%2C+Catherine+Y&rft.aulast=Toso&rft.aufirst=Laura&rft.date=2006-03-01&rft.volume=194&rft.issue=3&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemotherapy-induced neutropenia: a useful predictor of treatment efficacy? AN - 67726663; 16520781 JF - Nature clinical practice. Oncology AU - Di Maio, Massimo AU - Gridelli, Cesare AU - Gallo, Ciro AU - Perrone, Francesco AD - Clinical Trials Unit of the National Cancer Institute of Naples, Italy. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 114 EP - 115 VL - 3 IS - 3 SN - 1743-4254, 1743-4254 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Survival Analysis KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Neutropenia -- chemically induced KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67726663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Oncology&rft.atitle=Chemotherapy-induced+neutropenia%3A+a+useful+predictor+of+treatment+efficacy%3F&rft.au=Di+Maio%2C+Massimo%3BGridelli%2C+Cesare%3BGallo%2C+Ciro%3BPerrone%2C+Francesco&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2006-03-01&rft.volume=3&rft.issue=3&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Oncology&rft.issn=17434254&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-27 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weekly paclitaxel, 5-fluorouracil and folinic acid with granulocyte colony-stimulating factor support in metastatic breast cancer patients: a phase II study. AN - 67720903; 16520664 AB - We conducted a phase II study to determine the activity and tolerability of weekly paclitaxel, 5-fluorouracil (5-FU) and folinic acid plus granulocyte colony-stimulating factor (G-CSF) support in anthracycline-pre-treated or -resistant metastatic breast cancer patients. The phase II study was designed following the Simon optimal-two stage method. Patients received paclitaxel 80 mg/m, folinic acid 10 mg/m and bolus infusion of 5-FU 300 mg/m every week plus G-CSF on day 3 for 24 consecutive weeks in the absence of disease progression. From May 1998 to May 2000, 51 patients entered the study. Patients received a median relative dose intensity of 97.5% (range 81-100%). No severe toxicities were observed. Seven patients (14%) experienced neutropenia grade 2. Seven patients (14%) experienced grade 2 anemia. Two patients (4%) experienced severe asthenia. Three out of 50 evaluable patients [6%, 95% confidence interval (CI) 2-12.6%] showed a complete response, whereas 23 (46%, 95% CI 32.2-59.8%) had a partial response, with an overall response rate of 52% (95% CI 38.2-65.8%). In addition, eight patients (15.7%) had stable disease. In the 13 patients untreated for metastatic disease, the overall response rate was 92.3% (CI 77.8-100), with one complete response and 11 partial responses (84.6% CI 65-100%). In the whole group, the median time to progression and overall survival were 8 (range 1-18) and 14 months (95% CI 11-17), respectively. Thus, in metastatic breast cancer patients pre-treated with anthracyclines, the weekly administration of paclitaxel, 5-FU and folinic acid with G-CSF support seems to be extremely tolerable and active. JF - Anti-cancer drugs AU - Nistico, Cecilia AU - Bria, Emilio AU - Agostara, Biagio AU - Barni, Sandro AU - Colella, Elvira AU - Frontini, Luciano AU - D'Ottavio, Anna Maria AU - Cuppone, Federica AU - Valenza, Roberto AU - Sperduti, Isabella AU - Izzo, Fiorentino AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Roma, Italy. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 345 EP - 351 VL - 17 IS - 3 SN - 0959-4973, 0959-4973 KW - Anthracyclines KW - 0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Paclitaxel KW - P88XT4IS4D KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Drug Administration Schedule KW - Anthracyclines -- pharmacology KW - Humans KW - Leucovorin -- administration & dosage KW - Aged KW - Leucovorin -- adverse effects KW - Drug Resistance, Neoplasm KW - Fluorouracil -- administration & dosage KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Fluorouracil -- adverse effects KW - Paclitaxel -- adverse effects KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67720903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Weekly+paclitaxel%2C+5-fluorouracil+and+folinic+acid+with+granulocyte+colony-stimulating+factor+support+in+metastatic+breast+cancer+patients%3A+a+phase+II+study.&rft.au=Nistico%2C+Cecilia%3BBria%2C+Emilio%3BAgostara%2C+Biagio%3BBarni%2C+Sandro%3BColella%2C+Elvira%3BFrontini%2C+Luciano%3BD%27Ottavio%2C+Anna+Maria%3BCuppone%2C+Federica%3BValenza%2C+Roberto%3BSperduti%2C+Isabella%3BIzzo%2C+Fiorentino%3BTerzoli%2C+Edmondo&rft.aulast=Nistico&rft.aufirst=Cecilia&rft.date=2006-03-01&rft.volume=17&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers. AN - 67714355; 16325293 AB - Alcoholism and heavy drinking are associated with a number of physiological, behavioral, affective, and cognitive problems. One such problem involves dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, with alcoholics showing higher basal cortisol levels and reduced inhibitory feedback control. In addition, alcohol consumption is associated with decreased heart rate variability (HRV). In the present study we examined the relationships among alcohol consumption, cortisol excretion, and HRV in 542 apparently healthy men. Men in the top tertile of self-reported alcohol consumption had higher cortisol levels and lower HRV compared to men in the lower two tertiles of alcohol consumption. In addition, the inverse relationship between cortisol and HRV was greatly attenuated in the heavy drinking group even after accounting for a number of potential confounding factors. These results support prior research on the HPA axis dysregulation in alcoholics and suggest impaired inhibitory control of the HPA axis in heavy drinkers. The findings are consistent with the neurovisceral integration model, which links central and peripheral processes, and may provide a comprehensive framework for the future investigation of the complex mix of physiological, behavioral, affective, and cognitive factors which comprise the heavy drinking phenotype. JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology AU - Thayer, Julian F AU - Hall, Martica AU - Sollers, John J AU - Fischer, Joachim E AD - National Institute on Aging, NIA/GRC/LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224, United States. thayerj@grc.nia.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 244 EP - 250 VL - 59 IS - 3 SN - 0167-8760, 0167-8760 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Reference Values KW - Electrocardiography, Ambulatory KW - Humans KW - Prefrontal Cortex -- physiopathology KW - Neural Inhibition -- physiology KW - Heart -- innervation KW - Amygdala -- physiopathology KW - Feedback -- physiology KW - Electrocardiography KW - Adult KW - Middle Aged KW - Parasympathetic Nervous System -- physiopathology KW - Adolescent KW - Male KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Pituitary-Adrenal System -- physiopathology KW - Heart Rate -- physiology KW - Alcohol Drinking -- physiopathology KW - Alcohol Drinking -- adverse effects KW - Hydrocortisone -- urine KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67714355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+psychophysiology+%3A+official+journal+of+the+International+Organization+of+Psychophysiology&rft.atitle=Alcohol+use%2C+urinary+cortisol%2C+and+heart+rate+variability+in+apparently+healthy+men%3A+Evidence+for+impaired+inhibitory+control+of+the+HPA+axis+in+heavy+drinkers.&rft.au=Thayer%2C+Julian+F%3BHall%2C+Martica%3BSollers%2C+John+J%3BFischer%2C+Joachim+E&rft.aulast=Thayer&rft.aufirst=Julian&rft.date=2006-03-01&rft.volume=59&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=International+journal+of+psychophysiology+%3A+official+journal+of+the+International+Organization+of+Psychophysiology&rft.issn=01678760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-01 N1 - Date created - 2006-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure. AN - 67704885; 16507464 AB - Our previous work has shown that exposure to inorganic arsenic in utero produces hepatocellular carcinoma (HCC) in adult male mice. To explore further the molecular mechanisms of transplacental arsenic hepatocarcinogenesis, we conducted a second arsenic transplacental carcinogenesis study and used a genomewide microarray to profile arsenic-induced aberrant gene expression more extensively. Briefly, pregnant C3H mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from days 8 to 18 of gestation. The incidence of HCC in adult male offspring was increased 4-fold and tumor multiplicity 3-fold after transplacental arsenic exposure. Samples of normal liver and liver tumors were taken at autopsy for genomic analysis. Arsenic exposure in utero resulted in significant alterations (p 90% concordance. Arsenic-altered gene expression included activation of oncogenes and HCC biomarkers, and increased expression of cell proliferation-related genes, stress proteins, and insulin-like growth factors and genes involved in cell-cell communications. Liver feminization was evidenced by increased expression of estrogen-linked genes and altered expression of genes that encode gender-related metabolic enzymes. These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis. JF - Environmental health perspectives AU - Liu, Jie AU - Xie, Yaxiong AU - Ducharme, Danica M K AU - Shen, Jun AU - Diwan, Bhalchandra A AU - Merrick, B Alex AU - Grissom, Sherry F AU - Tucker, Charles J AU - Paules, Richard S AU - Tennant, Raymond AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 404 EP - 411 VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Maternal-Fetal Exchange KW - Gene Expression Profiling KW - Animals KW - Mice, Inbred C3H KW - Toxicogenetics KW - Mice KW - Male KW - Female KW - Pregnancy KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Arsenic -- toxicity KW - Liver -- drug effects KW - Liver -- metabolism KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67704885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+gene+expression+associated+with+hepatocarcinogenesis+in+adult+male+mice+induced+by+in+utero+arsenic+exposure.&rft.au=Liu%2C+Jie%3BXie%2C+Yaxiong%3BDucharme%2C+Danica+M+K%3BShen%2C+Jun%3BDiwan%2C+Bhalchandra+A%3BMerrick%2C+B+Alex%3BGrissom%2C+Sherry+F%3BTucker%2C+Charles+J%3BPaules%2C+Richard+S%3BTennant%2C+Raymond%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Carcinog. 2001 Feb;30(2):79-87 [11241755] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Anticancer Res. 2001 Mar-Apr;21(2B):1339-45 [11396210] Toxicol Appl Pharmacol. 2000 Apr 15;164(2):161-70 [10764629] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] Cancer Res. 2000 Jul 1;60(13):3445-53 [10910055] Environ Health Perspect. 2000 Jul;108(7):655-61 [10903620] J Toxicol Clin Toxicol. 2000;38(4):395-405 [10930056] Toxicol Sci. 2001 Jan;59(1):185-92 [11134558] Cancer Res. 2001 Jul 15;61(14):5389-95 [11454681] Mol Pharmacol. 2001 Aug;60(2):302-9 [11455017] Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8 [11559025] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Environ Health Perspect. 2002 Feb;110(2):119-22 [11836136] Toxicol Lett. 2002 Mar 10;128(1-3):73-84 [11869819] Carcinogenesis. 2002 May;23(5):777-85 [12016150] Int J Cancer. 2002 Jun 10;99(5):629-34 [12115494] Carcinogenesis. 2002 Aug;23(8):1387-97 [12151359] Alcohol. 2002 Jul;27(3):155-62 [12163143] Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 [12426152] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Carcinogenesis. 2003 Apr;24(4):757-70 [12727805] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Horm Metab Res. 2003 Nov-Dec;35(11-12):685-93 [14710347] Toxicol Pathol. 2004 Jan-Feb;32(1):64-72 [14713550] Toxicol Sci. 2004 Feb;77(2):249-57 [14691202] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Am J Public Health. 2004 May;94(5):741-4 [15117692] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Lab Invest. 2004 Sep;84(9):1137-47 [15220935] Environ Health Perspect. 2004 Aug;112(12):1255-63 [15345372] J Toxicol Environ Health A. 2004 Oct 8;67(19):1491-500 [15371225] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] J Hyg Epidemiol Microbiol Immunol. 1988;32(2):137-46 [2457611] J Pharmacol Exp Ther. 1996 May;277(2):1026-33 [8627513] J Gastroenterol Hepatol. 1997 Oct;12(9-10):S294-308 [9407350] Mol Cell Biol. 1998 Aug;18(8):4499-508 [9671459] Toxicol Sci. 1998 Aug;44(2):185-90 [9742656] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] World J Gastroenterol. 2004 Dec 1;10(23):3414-8 [15526358] Int J Oncol. 2005 Feb;26(2):369-77 [15645121] FEBS J. 2005 Jan;272(2):413-21 [15654879] Oncogene. 2005 Mar 10;24(11):1831-46 [15674350] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8644-9 [15937110] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice. AN - 67703469; 16180012 AB - Fifteen-day and 14-week studies of 2-methylimidazole (2MI) and 4-methylimidazole (4MI) were conducted because of widespread human exposure via ingestion of food products containing the compounds and lack of toxicity data. Groups of five male and five female Fischer rats and B6C3F1 mice were administered 2MI by dosed feed at 0, 1,200, 3,300, or 10,000 ppm or 4MI at 0, 300, 800, or 2,500 ppm for 15 days, and groups of 10 male and 10 female Fischer rats and B6C3F1 mice were administered 2MI or 4MI at 0, 625, 1,250, 2,500, 5,000 or 10,000 ppm for 14 weeks. In the 15-day studies, 2MI induced thyroid follicular-cell hyperplasia and pituitary pars-distalis hypertrophy in rats and thyroid follicular-cell hypertrophy and spleen hematopoietic-cell proliferation in mice; 4MI induced no histopathological changes in rats and mice. In the 14-week studies, 2MI increased concentrations of thyroid-stimulating hormone (TSH) and decreased those of thyroxine (T(4)) and triiodothyroxine (T(3)) in male and female rats according to the dosage. Incidences of diffuse follicular-cell hyperplasia of the thyroid gland increased significantly in male rats exposed to 1,250 ppm or greater and female rats exposed to 2,500 ppm or greater. Thyroid follicular-cell adenoma was diagnosed in two males in the 10,000-ppm group. A dose-related anemia occurred in female rats. In mice, follicular-cell hypertrophy of the thyroid gland, anemia, splenic hematopoietic-cell proliferation, and hemosiderin in kidney tubules appeared. In rats, 4MI induced tremors and ataxia in the high-dose groups. Serum T(3), T(4), and TSH levels were not altered, and no thyroid lesions occurred. Anemia, hepatocytic vacuolation, testicular degeneration, and prostatic atrophy were observed. In mice, anemia, liver cytoplasmic vacuolization, and renal degeneration and dilation occurred. Our studies demonstrated that, in rats and mice, 2MI induces thyroid hyperplasia and hypertrophy, and both 2MI and 4MI induce anemia; 2MI induces thyroid follicular-cell adenoma in male rats. JF - Archives of toxicology AU - Chan, Po AU - Mahler, Joel AU - Travlos, Greg AU - Nyska, Abraham AU - Wenk, M AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. chanp@niehs.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 169 EP - 180 VL - 80 IS - 3 SN - 0340-5761, 0340-5761 KW - Imidazoles KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyroxine KW - Q51BO43MG4 KW - 4-methylimidazole KW - Q64GF9FV4I KW - 2-methylimidazole KW - T0049Z45LZ KW - Index Medicus KW - Neoplasms, Experimental -- epidemiology KW - Molecular Structure KW - Animals KW - Hyperplasia -- pathology KW - Sex Factors KW - Triiodothyronine -- blood KW - Dose-Response Relationship, Drug KW - Toxicity Tests, Acute -- methods KW - Mice KW - Thyroxine -- blood KW - Neoplasms, Experimental -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Hyperplasia -- chemically induced KW - Hypertrophy -- pathology KW - Neoplasms, Experimental -- chemically induced KW - Incidence KW - Hypertrophy -- chemically induced KW - Female KW - Male KW - Toxicity Tests, Chronic -- methods KW - Thyroid Diseases -- pathology KW - Imidazoles -- toxicity KW - Imidazoles -- administration & dosage KW - Thyroid Diseases -- chemically induced KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67703469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Induction+of+thyroid+lesions+in+14-week+toxicity+studies+of+2+and+4-methylimidazole+in+Fischer+344%2FN+rats+and+B6C3F1+mice.&rft.au=Chan%2C+Po%3BMahler%2C+Joel%3BTravlos%2C+Greg%3BNyska%2C+Abraham%3BWenk%2C+M&rft.aulast=Chan&rft.aufirst=Po&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. AN - 67698974; 16314872 AB - The neuropeptide galanin (GAL) is widely expressed in the central nervous system. Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. The coding sequence of the galanin gene, GAL, is highly conserved and a functional polymorphism has not yet been found. The aim of our study was, for the first time, to identify GAL haplotypes and investigate associations with alcoholism and anxiety. Seven single-nucleotide polymorphisms (SNPs) spanning GAL were genotyped in 65 controls from five populations: US and Finnish Caucasians, African Americans, Plains and Southwestern Indians. A single haplotype block with little evidence of historical recombination was observed for each population. Four tag SNPs were then genotyped in DSM-III-R lifetime alcoholics and nonalcoholics from two population isolates: 514 Finnish Caucasian men and 331 Plains Indian men and women. Tridimensional Personality Questionnaire harm avoidance (HA) scores, a dimensional measure of anxiety, were obtained. There was a haplotype association with alcoholism in both the Finnish (P=0.001) and Plains Indian (P=0.004) men. The SNPs were also significantly associated. Alcoholics were divided into high and low HA groups (>or= and or =10 cigarettes/d), only 12% of alcoholic men and 8% of alcoholic women smoked heavily (>20/d). In women, the COMT Val158 allele frequency was maximal in alcoholic smokers (0.85), decreasing to 0.74 in nonalcoholic smokers, 0.67 in alcoholic nonsmokers, and 0.64 in nonalcoholic nonsmokers (chi2 = 11.1, 3 df, p = 0.011). Women showed a main effect of Val158 on smoking (p=0.003). Both male and female alcoholics were more likely to have at least 1 Val158 allele compared with nonalcoholics (0.95 vs 0.88, p < 0.05). Approximately 30% of all participants were long-term, nonaddicted light, social smokers (3.6+/-1.7 cigarettes/d); they had the same Val158Met frequencies as nonsmokers. Haplotype analyses supported the Val158Met findings; however, only 1 of the 2 Val158 haplotypes was implicated. Plains Indians have different smoking and drinking patterns and considerably less comorbidity between alcoholism and heavy smoking compared with the general U.S. population. Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women. JF - Alcoholism, clinical and experimental research AU - Enoch, Mary-Anne AU - Waheed, Juwaria F AU - Harris, Claudia R AU - Albaugh, Bernard AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892-9412, USA. maennoch@niaaa.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 399 EP - 406 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Phosphodiesterase I KW - EC 3.1.4.1 KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Psychiatric Status Rating Scales KW - Haplotypes KW - Sex Characteristics KW - Polymorphism, Genetic KW - Humans KW - Adult KW - Phosphodiesterase I -- genetics KW - Indians, North American -- statistics & numerical data KW - Male KW - Female KW - Catechol O-Methyltransferase -- genetics KW - Alcoholism -- epidemiology KW - Smoking -- genetics KW - Alcoholism -- genetics KW - Alcoholism -- complications KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67690740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Sex+differences+in+the+influence+of+COMT+Val158Met+on+alcoholism+and+smoking+in+plains+American+Indians.&rft.au=Enoch%2C+Mary-Anne%3BWaheed%2C+Juwaria+F%3BHarris%2C+Claudia+R%3BAlbaugh%2C+Bernard%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion: analysis of morbidity and mortality in 209 peritoneal surface malignancies treated with closed abdomen technique. AN - 67688149; 16456817 AB - The purpose of this prospective Phase II study was to analyze morbidity and mortality of cytoreductive surgery (CRS) and intraperitoneal hyperthermic perfusion (IPHP) in the treatment of peritoneal surface malignancies. A total of 205 patients (50 with peritoneal mesothelioma, 49 with pseudomyxoma peritonei, 41 with ovarian cancer, 32 with abdominal sarcomatosis, 13 with colon cancer, 12 with gastric cancer, and 8 with carcinomatosis from other origins) underwent 209 consecutive procedures. Four patients underwent the intervention twice because of disease relapse. There were 70 men and 135 women. Mean age was 52 years (range, 22-76 yrs). CRS was performed by using peritonectomy procedures. IPHP through the closed abdomen technique was conducted with a preheated (42.5 degrees C) perfusate containing cisplatin + mitomycin C or cisplatin + doxorubicin. Major morbidity rate was 12%. The most significant complications were 23 anastomotic leaks or bowel perforations, 4 abdominal bleeds, and 4 sepses. Operative mortality rate was 0.9%. On logistic regression model multivariate analysis, extent of cytoreduction (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.29-6.40) and dose of cisplatin for IPHP > or = 240 mg (OR, 3.13; 95% CI, 1.24-7.90) were independent risk factors for major morbidity. Ten patients presented with Grade 3 to 4 toxicity. CRS + IPHP presented acceptable morbidity, toxicity, and mortality rates, all of which support prospective Phase III clinical trials. JF - Cancer AU - Kusamura, Shigeki AU - Younan, Rami AU - Baratti, Dario AU - Costanzo, Pasqualina AU - Favaro, Myriam AU - Gavazzi, Cecilia AU - Deraco, Marcello AD - Department of Surgery, National Cancer Institute of Milan, Milan, Italy. Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1144 EP - 1153 VL - 106 IS - 5 SN - 0008-543X, 0008-543X KW - Mitomycin KW - 50SG953SK6 KW - Doxorubicin KW - 80168379AG KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Neoplasm Recurrence, Local KW - Mitomycin -- administration & dosage KW - Infusions, Parenteral KW - Morbidity KW - Male KW - Female KW - Cisplatin -- administration & dosage KW - Hyperthermia, Induced KW - Peritoneal Neoplasms -- surgery KW - Peritoneal Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67688149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Psychotherapy+and+Counselling&rft.atitle=The+HoST+programme%3A+A+pilot+evaluation+of+modified+dialectical+behaviour+therapy+with+female+offenders+diagnosed+with+borderline+personality+disorder&rft.au=Gee%2C+Joanna%3BReed%2C+Simon&rft.aulast=Gee&rft.aufirst=Joanna&rft.date=2013-09-01&rft.volume=15&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Psychotherapy+and+Counselling&rft.issn=13642537&rft_id=info:doi/10.1080%2F13642537.2013.810659 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. AN - 67687356; 16495727 AB - This study assessed the effects of nicotine pre-exposure on subsequent locomotor and rewarding effects of repeated Delta-9-tetrahydrocannabinol administration in Sprague-Dawley rats. Repeated administration of the same dose of Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) did not produce significant tolerance or behavioral sensitization to Delta-9-tetrahydrocannabinol's locomotor effects. An unbiased place conditioning paradigm was then used to obtain a measure of the rewarding effects of Delta-9-tetrahydrocannabinol. Rats received an injection of either Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials) of a two-compartment apparatus. Control rats received saline injections associated with both compartments. Significant conditioned place preferences developed with 0.1 mg/kg Delta-9-tetrahydrocannabinol in control rats, but not in nicotine pre-exposed rats. Surprisingly, significant place aversions developed at higher 1 and 2 mg/kg doses of Delta-9-tetrahydrocannabinol in nicotine pre-exposed rats. To the extent that behavioral sensitization may reflect reward processes in drug dependence, the lack of behavioral sensitization on repeated Delta-9-tetrahydrocannabinol administration is consistent with the difficulties usually encountered in demonstrating rewarding or reinforcing effects of Delta-9-tetrahydrocannabinol in rats. The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol. JF - Behavioural pharmacology AU - Le Foll, Bernard AU - Wiggins, Marcus AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. blefoll@intra.nida.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 195 EP - 199 VL - 17 IS - 2 SN - 0955-8810, 0955-8810 KW - Hallucinogens KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Male KW - Reward KW - Nicotine -- pharmacology KW - Dronabinol -- pharmacology KW - Hallucinogens -- pharmacology KW - Motor Activity -- drug effects KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67687356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Nicotine+pre-exposure+does+not+potentiate+the+locomotor+or+rewarding+effects+of+Delta-9-tetrahydrocannabinol+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWiggins%2C+Marcus%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2006-03-01&rft.volume=17&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-06 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. AN - 67687246; 16495266 AB - Although transmissible spongiform encephalopathies (TSEs) are incurable, a key therapeutic approach is prevention of conversion of the normal, protease-sensitive form of prion protein (PrP-sen) to the disease-specific protease-resistant form of prion protein (PrP-res). Here degenerate phosphorothioate oligonucleotides (PS-ONs) are introduced as low-nM PrP-res conversion inhibitors with strong antiscrapie activities in vivo. Comparisons of various PS-ON analogs indicated that hydrophobicity and size were important, while base composition was only minimally influential. PS-ONs bound avidly to PrP-sen but could be displaced by sulfated glycan PrP-res inhibitors, indicating the presence of overlapping binding sites. Labeled PS-ONs also bound to PrP-sen on live cells and were internalized. This binding likely accounts for the antiscrapie activity. Prophylactic PS-ON treatments more than tripled scrapie survival periods in mice. Survival times also increased when PS-ONs were mixed with scrapie brain inoculum. With these antiscrapie activities and their much lower anticoagulant activities than that of pentosan polysulfate, degenerate PS-ONs are attractive new compounds for the treatment of TSEs. JF - Antimicrobial agents and chemotherapy AU - Kocisko, David A AU - Vaillant, Andrew AU - Lee, Kil Sun AU - Arnold, Kevin M AU - Bertholet, Nadine AU - Race, Richard E AU - Olsen, Emily A AU - Juteau, Jean-Marc AU - Caughey, Byron AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1034 EP - 1044 VL - 50 IS - 3 SN - 0066-4804, 0066-4804 KW - Oligonucleotides KW - 0 KW - Phosphates KW - PrPSc Proteins KW - phosphorodithioic acid KW - 8056RR93HU KW - Index Medicus KW - Injections, Intraperitoneal KW - Hydrophobic and Hydrophilic Interactions KW - Animals KW - Base Composition KW - Injections, Subcutaneous KW - Survival KW - Mice KW - Inhibitory Concentration 50 KW - Mice, Transgenic KW - Nucleic Acid Conformation KW - Molecular Weight KW - Cell Line KW - Cricetinae KW - PrPSc Proteins -- antagonists & inhibitors KW - Oligonucleotides -- pharmacology KW - Oligonucleotides -- chemistry KW - Phosphates -- chemistry KW - Scrapie -- prevention & control KW - PrPSc Proteins -- genetics KW - Oligonucleotides -- administration & dosage KW - Scrapie -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67687246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Potent+antiscrapie+activities+of+degenerate+phosphorothioate+oligonucleotides.&rft.au=Kocisko%2C+David+A%3BVaillant%2C+Andrew%3BLee%2C+Kil+Sun%3BArnold%2C+Kevin+M%3BBertholet%2C+Nadine%3BRace%2C+Richard+E%3BOlsen%2C+Emily+A%3BJuteau%2C+Jean-Marc%3BCaughey%2C+Byron&rft.aulast=Kocisko&rft.aufirst=David&rft.date=2006-03-01&rft.volume=50&rft.issue=3&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1986 Mar;67 ( Pt 3):463-73 [2419489] Neurosci Lett. 2005 Nov 11;388(2):106-11 [16039063] J Gen Virol. 1991 Feb;72 ( Pt 2):457-60 [1704414] J Gen Virol. 1992 Mar;73 ( Pt 3):661-5 [1372039] Nucleic Acids Symp Ser. 1991;(25):101-2 [1842039] J Virol. 1993 Feb;67(2):643-50 [7678300] FEBS Lett. 1993 Jun 28;325(1-2):123-7 [7685712] J Cell Physiol. 1993 Nov;157(2):319-25 [7901226] J Virol. 1994 Apr;68(4):2135-41 [7511169] Arch Virol. 1999;144(9):1751-63 [10542024] Eur J Immunol. 1999 Nov;29(11):3496-506 [10556804] J Virol. 2000 Jan;74(2):828-33 [10623745] Science. 2000 Feb 25;287(5457):1503-6 [10688802] Clin Cancer Res. 2000 May;6(5):1626-31 [10815879] J Virol. 2000 Jun;74(12):5432-40 [10823847] Immunology. 2000 Sep;101(1):46-52 [11012752] EMBO J. 2001 Feb 1;20(3):377-86 [11157745] J Biol Chem. 2001 Jun 1;276(22):19301-9 [11278562] J Pharm Biomed Anal. 1994 Nov;12(11):1345-53 [7849130] J Biol Chem. 1995 Dec 15;270(50):30221-9 [8530433] Toxicol Lett. 1995 Dec;82-83:425-30 [8597088] EMBO J. 2001 Jul 2;20(13):3351-8 [11432823] J Neurochem. 2001 Oct;79(1):79-87 [11595760] J Biol Chem. 2001 Dec 28;276(52):49400-9 [11604397] Clin Cancer Res. 2002 Mar;8(3):679-83 [11895895] J Mol Biol. 2002 Apr 19;318(1):149-59 [12054775] Lancet. 2002 Jul 20;360(9328):229-30 [12133662] J Biol Chem. 2003 Apr 4;278(14):12522-9 [12551897] J Virol. 2003 Oct;77(19):10288-94 [12970413] Br Med Bull. 2003;66:281-92 [14522865] Annu Rev Neurosci. 2003;26:267-98 [12704221] J Biol Chem. 2003 Oct 10;278(41):40041-9 [12871949] Nature. 2003 Oct 16;425(6959):717-20 [14562104] Nat Med. 2004 Feb;10(2):187-92 [14745443] J Virol. 2004 May;78(10):4999-5006 [15113880] Nat Rev Drug Discov. 2004 Oct;3(10):874-84 [15459678] J Clin Invest. 1996 Sep 1;98(5):1119-29 [8787674] FEBS Lett. 1997 Aug 18;413(2):277-81 [9280297] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83 [9811807] J Infect. 2005 Jun;50(5):394-6 [15907546] J Neurosci. 2005 May 25;25(21):5207-16 [15917460] J Biol Chem. 2005 Jul 22;280(29):26873-9 [15917229] J Chromatogr. 1990 Jun 22;509(2):396-9 [2211903] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds. AN - 67685003; 16492992 AB - In one study of children in 27 families with maternal retardation, those children with higher intelligence quotient (IQ) were more likely to have multiple behavior problems than those with lower IQ. If true, this result would affect clinical practice, but it has not been replicated. Because the setting of the initial observation is similar to the setting of childhood lead poisoning, we attempted a replication using data from the Treatment of Lead-Exposed Children (TLC) study, in which 780 children aged 12-33 mo with blood lead levels 20-44 microg/dL were randomized to either succimer treatment or placebo and then followed up to 5 y. Of 656 mothers of TLC children with IQ measured, 113 demonstrated mental retardation (IQ or=70, children with IQ >or=85 were rated more favorably on cognitive tests and behavioral questionnaires than children with IQ or=85 did not show more severe clinical behavioral problems, nor were they more likely to show multiple behavior problems. Children with higher IQ have fewer behavior problems, irrespective of the mother's IQ. In the special setting of mothers with IQ <70, children with higher IQ are not at greater risk of behavior problems. JF - Pediatric research AU - Chen, Aimin AU - Schwarz, Donald AU - Radcliffe, Jerilynn AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 471 EP - 477 VL - 59 IS - 3 SN - 0031-3998, 0031-3998 KW - Chelating Agents KW - 0 KW - Lead KW - 2P299V784P KW - Succimer KW - DX1U2629QE KW - Index Medicus KW - Lead Poisoning -- drug therapy KW - Succimer -- therapeutic use KW - Random Allocation KW - Humans KW - Mothers KW - Child KW - Intellectual Disability KW - Lead -- blood KW - Child, Preschool KW - Lead Poisoning -- physiopathology KW - Chelating Agents -- therapeutic use KW - Neuropsychological Tests KW - Female KW - Male KW - Social Environment KW - Intelligence Tests KW - Child Behavior Disorders -- physiopathology KW - Urban Population KW - Intelligence -- physiology KW - Achievement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+research&rft.atitle=Maternal+IQ%2C+child+IQ%2C+behavior%2C+and+achievement+in+urban+5-7+year+olds.&rft.au=Chen%2C+Aimin%3BSchwarz%2C+Donald%3BRadcliffe%2C+Jerilynn%3BRogan%2C+Walter+J&rft.aulast=Chen&rft.aufirst=Aimin&rft.date=2006-03-01&rft.volume=59&rft.issue=3&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Pediatric+research&rft.issn=00313998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Dec 2;402(6761 Suppl):C25-9 [10591222] Environ Health Perspect. 2005 Jul;113(7):894-9 [16002379] N Engl J Med. 2001 May 10;344(19):1421-6 [11346806] Psychol Rev. 2001 Apr;108(2):346-69 [11381833] Scand J Psychol. 2001 Dec;42(5):437-44 [11771813] J Child Psychol Psychiatry. 2004 May;45(4):779-88 [15056309] Pediatrics. 2004 Jul;114(1):19-26 [15231903] J Child Psychol Psychiatry. 1981 Oct;22(4):375-92 [7053050] Psychol Med. 1983 Nov;13(4):891-4 [6665104] J Clin Psychol. 1985 Jan;41(1):95-7 [3973047] Child Psychiatry Hum Dev. 1985 Summer;15(4):255-68 [4042738] Am J Ment Defic. 1985 Nov;90(3):253-8 [2417482] Psychopharmacol Bull. 1985;21(4):773-800 [4089106] Arch Gen Psychiatry. 1987 Sep;44(9):832-6 [3498458] Analyst. 1987 Dec;112(12):1701-4 [3445938] J Genet Psychol. 1990 Jun;151(2):139-51 [2388050] J Clin Psychol. 1992 Mar;48(2):151-64 [1573013] J Child Psychol Psychiatry. 1992 Oct;33(7):1255-61 [1400707] Am J Public Health. 1992 Oct;82(10):1356-60 [1415859] Environ Res. 1994 Apr;65(1):42-55 [8162884] BMJ. 1994 Nov 5;309(6963):1189-97 [7987149] J Child Psychol Psychiatry. 1995 Mar;36(3):409-25 [7782405] Am J Ment Retard. 1997 Jan;101(4):352-64 [9017082] Am J Public Health. 1998 Mar;88(3):481-6 [9518990] J Pediatr Psychol. 1998 Jun;23(3):197-205 [9640899] Paediatr Perinat Epidemiol. 1998 Jul;12(3):313-33 [9690266] Am J Epidemiol. 1999 Apr 15;149(8):740-9 [10206624] Psychol Bull. 1999 Jul;125(4):392-409 [10414224] J Dev Behav Pediatr. 2004 Dec;25(6):407-14 [15613989] Eur Child Adolesc Psychiatry. 1999;8 Suppl 4:41-7 [10654132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monoclonal antibodies and multifunctional cytochrome P450: drug metabolism as paradigm. AN - 67679581; 16490812 AB - Monoclonal antibodies are reagents par excellence for analyzing the role of individual cytochrome P450 isoforms in multifunctional biological activities catalyzed by cytochrome P450 enzymes. The precision and utility of the monoclonal antibodies have heretofore been applied primarily to studies of human drug metabolism. The unique and precise specificity and high inhibitory activity toward individual cytochrome P450s make the monoclonal antibodies extraordinary tools for identifying and quantifying the role of each P450 isoform in the metabolism of a drug or nondrug xenobiotic. The monoclonal antibodies identify drugs metabolized by individual, several, or polymorphic P450s. A comprehensive collection of monoclonal antibodies has been isolated to human P450s: 1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C family, 2C19, 2D6, 2E1, 3A4/5, and 2J2. The monoclonal antibodies can also be used for identifying drugs and/or metabolites useful as markers for in vivo phenotyping. Clinical identification of a patient's phenotype, coupled with precise knowledge of a drug's metabolism, should lead to a reduction of adverse drug reactions and improved drug therapeutics, thereby promoting advances in drug discovery. JF - Journal of clinical pharmacology AU - Gelboin, Harry V AU - Krausz, Kristopher AD - Laboratory of Metabolism, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892-0001, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 353 EP - 372 VL - 46 IS - 3 SN - 0091-2700, 0091-2700 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - Pharmaceutical Preparations KW - Protein Isoforms KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Phenotype KW - Alleles KW - Humans KW - Pharmaceutical Preparations -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Microsomes, Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- physiology KW - Inactivation, Metabolic -- physiology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Inactivation, Metabolic -- genetics KW - Antibodies, Monoclonal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Disorders&rft.atitle=The+specific+role+of+childhood+abuse%2C+parental+bonding%2C+and+family+functioning+in+female+adolescents+with+borderline+personality+disorder&rft.au=Infurna%2C+Maria+Rita%3BBrunner%2C+Romuald%3BHolz%2C+Birger%3BParzer%2C+Peter%3BGiannone%2C+Francesca%3BReichl%2C+Corinna%3BFischer%2C+Gloria%3BResch%2C+Franz%3BKaess%2C+Michael&rft.aulast=Infurna&rft.aufirst=Maria&rft.date=2016-04-01&rft.volume=30&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Disorders&rft.issn=0885579X&rft_id=info:doi/10.1521%2Fpedi_2015_29_186 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-06 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. AN - 67677468; 16043203 AB - Indole-3-carbinol (I-3-C) and 3,3'-diindolylmethane (DIM) have been shown to reduce the incidence and multiplicity of cancers in laboratory animal models. Based on the observation that I-3-C induced hepatocyte hypertrophy when administered orally for 13 weeks to rats, a treatment and recovery study was undertaken to test the hypothesis that the induction of hepatocyte hypertrophy and cytochrome P450 (CYP) activity by I-3-C are adaptive, reversible responses. Additionally, we directly compared the effects of I-3-C to those of its principle metabolite DIM. Rats were treated orally for 28 days with 2 doses of I-3-C (5 and 50 mg I-3-C/kg body weight/day) and DIM (7.5 and 75 mg DIM/kg body weight/day) and then one-half of the animals were not treated for an additional 28 days. Organ weights, histopathology, and the CYP enzyme activities of 1A1/2, 2B1/2, 2C9, 2D6, 2E1, 3A4, and 19 A were measured both after treatment and after recovery. Oral administration of 50 mg I-3-C/kg body weight/day to rats for 28 days significantly increased liver weights and CYP enzyme activities. The effects in males were more pronounced and persistent after recovery than the effects in females. The increased organ weights returned to control values after treatment. Conversely, DIM did not alter liver weights and had no effect on CYP activities after the 28-day treatment. Some changes in CYP activities were measured after the DIM recovery period but the magnitudes of the changes were considered biologically insignificant. The results show that I-3-C, but not DIM, induces reversible adaptive responses in the liver. JF - Toxicology and applied pharmacology AU - Crowell, James A AU - Page, John G AU - Levine, Barry S AU - Tomlinson, Michael J AU - Hebert, Charles D AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7322, USA. jc94@nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 115 EP - 123 VL - 211 IS - 2 SN - 0041-008X, 0041-008X KW - Indoles KW - 0 KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - indole-3-carbinol KW - C11E72455F KW - Aldehyde Reductase KW - EC 1.1.1.21 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - 3,3'-diindolylmethane KW - SSZ9HQT61Z KW - Index Medicus KW - Administration, Oral KW - Prostate -- drug effects KW - Animals KW - Kidney -- pathology KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Glutathione Transferase -- metabolism KW - Prostate -- metabolism KW - Kidney -- drug effects KW - Spleen -- pathology KW - Cell Enlargement -- drug effects KW - Aldehyde Reductase -- metabolism KW - Metabolic Detoxication, Phase II -- physiology KW - Uterus -- drug effects KW - Isoenzymes -- metabolism KW - Uterus -- metabolism KW - Rats KW - Toxicity Tests, Chronic -- methods KW - Rats, Sprague-Dawley KW - Spleen -- drug effects KW - Time Factors KW - Female KW - Male KW - Organ Size -- drug effects KW - Hepatocytes -- drug effects KW - Indoles -- toxicity KW - Hepatocytes -- ultrastructure KW - Indoles -- administration & dosage KW - Indoles -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Hepatocytes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67677468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Indole-3-carbinol%2C+but+not+its+major+digestive+product+3%2C3%27-diindolylmethane%2C+induces+reversible+hepatocyte+hypertrophy+and+cytochromes+P450.&rft.au=Crowell%2C+James+A%3BPage%2C+John+G%3BLevine%2C+Barry+S%3BTomlinson%2C+Michael+J%3BHebert%2C+Charles+D&rft.aulast=Crowell&rft.aufirst=James&rft.date=2006-03-01&rft.volume=211&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-19 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. AN - 67672162; 16426829 AB - There is increasing evidence that dysregulation of energy homeostasis is associated with colorectal carcinogenesis. Epidemiological data have consistently demonstrated a positive relation between increased body size and colorectal malignancy, whereas mechanistic studies have sought to uncover obesity-related carcinogenic pathways. The phenomenon of "insulin resistance" or the impaired ability to normalize plasma glucose levels has formed the core of these pathways, but other mechanisms have also been advanced. Obesity-induced insulin resistance leads to elevated levels of plasma insulin, glucose and fatty acids. Exposure of the colonocyte to heightened concentrations of insulin may induce a mitogenic effect within these cells, whereas exposure to glucose and fatty acids may induce metabolic perturbations, alterations in cell signaling pathways and oxidative stress. The importance of chronic inflammation in the pathogenesis of obesity has recently been highlighted and may represent an additional mechanism linking increased adiposity to colorectal carcinogenesis. This review provides an overview of the epidemiology of body size and colorectal neoplasia and outlines current knowledge of putative mechanisms advanced to explain this relation. Family based studies have shown that the propensity to become obese is heritable, but this is only manifest in conditions of excess energy intake over expenditure. Inheritance of a genetic profile that predisposes to increased body size may also be predictive of colorectal cancer. Genomewide scans, linkage studies and candidate gene investigations have highlighted more than 400 chromosomal regions that may harbor variants that predispose to increased body size. The genetics underlying the pathogenesis of obesity are likely to be complex, but variants in a range of different genes have already been associated with increased body size and insulin resistance. These include genes encoding elements of insulin signaling, adipocyte metabolism and differentiation, and regulation of energy expenditure. A number of investigators have begun to study genetic variants within these pathways in relation to colorectal neoplasia, but at present data remain limited to a handful of studies. These pathways will be discussed with particular reference to genetic polymorphisms that have been associated with obesity and insulin resistance. JF - The Journal of nutritional biochemistry AU - Gunter, Marc J AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA. gunterm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 145 EP - 156 VL - 17 IS - 3 SN - 0955-2863, 0955-2863 KW - Insulin KW - 0 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Insulin-Like Growth Factor II KW - 67763-97-7 KW - Growth Hormone KW - 9002-72-6 KW - Index Medicus KW - Animals KW - Humans KW - Energy Metabolism -- genetics KW - Insulin -- genetics KW - Insulin-Like Growth Factor II -- genetics KW - Insulin -- metabolism KW - Cell Differentiation -- genetics KW - Exercise KW - Inflammation KW - Insulin-Like Growth Factor I -- genetics KW - Growth Hormone -- genetics KW - Signal Transduction -- genetics KW - Adipocytes -- metabolism KW - Chronic Disease KW - Insulin Resistance KW - Diet KW - Body Size KW - Colonic Neoplasms -- epidemiology KW - Colonic Neoplasms -- genetics KW - Obesity -- genetics KW - Colonic Neoplasms -- complications KW - Obesity -- epidemiology KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67672162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=Obesity+and+colorectal+cancer%3A+epidemiology%2C+mechanisms+and+candidate+genes.&rft.au=Gunter%2C+Marc+J%3BLeitzmann%2C+Michael+F&rft.aulast=Gunter&rft.aufirst=Marc&rft.date=2006-03-01&rft.volume=17&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=09552863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-06 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Allyl sulfur compounds from garlic modulate aberrant crypt formation. AN - 67669952; 16484579 AB - The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided. JF - The Journal of nutrition AU - Ross, Sharon A AU - Finley, John W AU - Milner, John A AD - Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Rockville, MD 20892-7328, USA. rosssha@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 852S EP - 854S VL - 136 IS - 3 Suppl SN - 0022-3166, 0022-3166 KW - Anticarcinogenic Agents KW - 0 KW - Plant Extracts KW - Sulfinic Acids KW - Index Medicus KW - Animals KW - Adenoma -- prevention & control KW - Sulfinic Acids -- therapeutic use KW - Disease Models, Animal KW - Rodentia KW - Anticarcinogenic Agents -- therapeutic use KW - Precancerous Conditions -- prevention & control KW - Plant Extracts -- therapeutic use KW - Garlic KW - Colonic Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67669952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Development&rft.atitle=Prosocial+behavior%3A+Long%E2%80%90term+trajectories+and+psychosocial+outcomes&rft.au=Flynn%2C+Elinor%3BEhrenreich%2C+Samuel+E.%3BBeron%2C+Kurt+J.%3BUnderwood%2C+Marion+K.&rft.aulast=Flynn&rft.aufirst=Elinor&rft.date=2015-08-01&rft.volume=24&rft.issue=3&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Social+Development&rft.issn=0961205X&rft_id=info:doi/10.1111%2Fsode.12100 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74. Phase II study. AN - 67665479; 16175356 AB - Febrile neutropenia (FN) remains a potentially life-threatening complication of anticancer chemotherapy. Bacterial translocation via intestinal mucosa is a significant mechanism of FN development. Competitive inhibition of bowel colonization by pathogenic microorganisms by lactic acid bacteria could be a useful prevention of FN. The aim of the study was the prevention of FN by probiotic strain Enterococcus faecium M-74 enriched with selenium in leukemic patients. Fourteen (six males/eight females) patients with myelogenous leukemia treated by induction or consolidation chemotherapy were included in the study. Patients received prophylaxis with E. faecium M-74 during one cycle of chemotherapy. The daily dose was 36 x 10(9) CFU tid. Prophylaxis started between day -2 and day +2 of chemotherapy and continued until the absolute neutrophile count (ANC) was >1,000/microl. All patients experienced febrile neutropenia. During 231 days of severe neutropenia, 30 febrile episodes occurred. No any febrile episode or infection provoked by the strain tested was noticed. Tolerance of therapy was excellent without significant adverse effects. Our results demonstrate the safety of the probiotic strain E. faecium M-74 enriched with selenium in leukemic patients with severe neutropenia. However, its administration was not effective in the prevention of febrile neutropenia, but this does not preclude the protective effect of other probiotic strains. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Mego, M AU - Koncekova, R AU - Mikuskova, E AU - Drgona, L AU - Ebringer, L AU - Demitrovicova, L AU - Nemova, I AU - Trupl, J AU - Mardiak, J AU - Koza, I AU - Zajac, V AD - Department of Medical Oncology, National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovakia. misomego@mediclub.sk Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 285 EP - 290 VL - 14 IS - 3 SN - 0941-4355, 0941-4355 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Slovakia -- epidemiology KW - Middle Aged KW - Male KW - Female KW - Fever -- prevention & control KW - Fever -- complications KW - Neutropenia -- epidemiology KW - Neutropenia -- complications KW - Neutropenia -- prevention & control KW - Neutropenia -- chemically induced KW - Probiotics -- therapeutic use KW - Enterococcus faecium KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67665479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Prevention+of+febrile+neutropenia+in+cancer+patients+by+probiotic+strain+Enterococcus+faecium+M-74.+Phase+II+study.&rft.au=Mego%2C+M%3BKoncekova%2C+R%3BMikuskova%2C+E%3BDrgona%2C+L%3BEbringer%2C+L%3BDemitrovicova%2C+L%3BNemova%2C+I%3BTrupl%2C+J%3BMardiak%2C+J%3BKoza%2C+I%3BZajac%2C+V&rft.aulast=Mego&rft.aufirst=M&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. AN - 67658244; 16476034 AB - We examined the toxicity and biodistribution associated with a single administration of a first-generation, serotype 5, adenoviral vector encoding human growth hormone (hGH; AdCMVhGH) to a single rat submandibular gland in the presence of hydroxychloroquine (HCQ). Previously, we showed that hGH is primarily secreted into saliva (approximately ninefold serum level) when expressed as a transgene in salivary glands (e.g. Baum et al, 1999), but administration of HCQ substantially increases the hGH levels secreted into the bloodstream (Hoque et al, 2001). A potential application of this observation is for patients with adult hGH deficiency. Six groups of male and female adult rats (n = 12 each) were studied, with zero to 1.5 x 10(11) particles of AdCMVhGH, +/-HCQ, administered retroductally. Multiple clinical and pathological parameters, as well as vector tissue distribution, were assessed. All animals survived until the scheduled day of sacrifice, and essentially no untoward events were observed clinically or at gross necropsy. We observed no vector-related effects on clinical hematology evaluations and a single, transient significant change on clinical chemistry evaluations (increased serum globulin levels). Three days after AdCMVhGH administration, the vector distributed to all tissues analyzed with the exception of gonads and heart. By day 29, most organs, other than the targeted and contralateral submandibular glands, were negative for the presence of vector. On day 3, none of the animals tested positive for the presence of replication competent adenovirus in either their blood or saliva. Salivary gland delivery of AdCMVhGH +/-HCQ appears associated with limited toxicity in rats. JF - Oral diseases AU - Zheng, C AU - Voutetakis, A AU - Kok, M R AU - Goldsmith, C M AU - Smith, G B J AU - Elmore, S AU - Nyska, A AU - Vallant, M AU - Irwin, R D AU - Baum, B J AD - Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD 20892-1190, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 137 EP - 144 VL - 12 IS - 2 SN - 1354-523X, 1354-523X KW - Antirheumatic Agents KW - 0 KW - Recombinant Proteins KW - Serum Globulins KW - Human Growth Hormone KW - 12629-01-5 KW - Hydroxychloroquine KW - 4QWG6N8QKH KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Amylases KW - EC 3.2.1.- KW - Dentistry KW - Virus Replication KW - Animals KW - Plasmids -- genetics KW - Humans KW - Tissue Distribution KW - Alkaline Phosphatase -- blood KW - Rats KW - Alanine Transaminase -- blood KW - Rats, Inbred F344 KW - L-Lactate Dehydrogenase -- blood KW - Amylases -- blood KW - Serum Globulins -- analysis KW - Female KW - Male KW - Submandibular Gland -- metabolism KW - Human Growth Hormone -- toxicity KW - Human Growth Hormone -- genetics KW - Hydroxychloroquine -- pharmacology KW - Submandibular Gland -- drug effects KW - Antirheumatic Agents -- pharmacology KW - Genetic Vectors -- genetics KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67658244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+diseases&rft.atitle=Toxicity+and+biodistribution+of+a+first-generation+recombinant+adenoviral+vector%2C+in+the+presence+of+hydroxychloroquine%2C+following+retroductal+delivery+to+a+single+rat+submandibular+gland.&rft.au=Zheng%2C+C%3BVoutetakis%2C+A%3BKok%2C+M+R%3BGoldsmith%2C+C+M%3BSmith%2C+G+B+J%3BElmore%2C+S%3BNyska%2C+A%3BVallant%2C+M%3BIrwin%2C+R+D%3BBaum%2C+B+J&rft.aulast=Zheng&rft.aufirst=C&rft.date=2006-03-01&rft.volume=12&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Oral+diseases&rft.issn=1354523X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deamidation of peptides in aerobic nitric oxide solution by a nitrosative pathway. AN - 67630435; 16249103 AB - Hydrolytic deamidation of asparagine (Asn) and glutamine (Gln) residues to aspartate (Asp) and glutamate (Glu), respectively, can have significant biological consequences. We hypothesize that a wholly different mechanism of deamidation might occur in the presence of aerobic nitric oxide (NO). Accordingly, we examined the deamidating ability of aerobic NO toward three model peptides, 2,4-dinitrophenyl (DNP)-Pro-Gln-Gly, Lys-Trp-Asp-Asn-Gln, and Ser-Glu-Asn-Tyr-Pro-Ile-Val, incubating them with the NO-generating compound, Et(2)N[N(O)NO]Na (DEA/NO, 30-48 mM), in aerobic, pH 7.4, buffer at 37 degrees C. DNP-Pro-Glu-Gly was detected after 2 h, while Lys-Trp-Asp-Asp-Gln, Lys-Trp-Asp-Asn-Glu, and Ser-Glu-Asp-Tyr-Pro-Ile-Val were detected within 10 min, accumulating in apparent yields of up to approximately 10%. In the latter case, tyrosine nitration was also observed, producing the expected nitrotyrosine residue. DEA/NO solutions preincubated to exhaust the NO before the peptides were added did not induce detectable deamidation. The data demonstrate that aerobic NO exposures can lead to nitrosative deamidation of peptides, a pathway that differs from the established hydrolytic deamidation mechanism in several key respects: the by-products of the former are molecular nitrogen and an acid (HONO) while that of the latter is a base (NH(3)); the nitrosative path can in principle proceed in the absence of water molecules; Asn is much more easily deamidated than Gln in the hydrolytic pathway, while the two amino acid residues were deamidated to a similar extent by exposure to NO in the presence of oxygen. JF - Nitric oxide : biology and chemistry AU - Kong, Li AU - Saavedra, Joseph E AU - Buzard, Gregory S AU - Xu, Xia AU - Hood, Brian L AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 144 EP - 151 VL - 14 IS - 2 SN - 1089-8603, 1089-8603 KW - Amino Acids KW - 0 KW - Macromolecular Substances KW - Peptides KW - Pharmaceutical Preparations KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Models, Chemical KW - Amino Acids -- chemistry KW - Peptides -- metabolism KW - Peptides -- chemistry KW - Nitric Oxide -- physiology KW - Amino Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67630435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Deamidation+of+peptides+in+aerobic+nitric+oxide+solution+by+a+nitrosative+pathway.&rft.au=Kong%2C+Li%3BSaavedra%2C+Joseph+E%3BBuzard%2C+Gregory+S%3BXu%2C+Xia%3BHood%2C+Brian+L%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BKeefer%2C+Larry+K&rft.aulast=Kong&rft.aufirst=Li&rft.date=2006-03-01&rft.volume=14&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=10898603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-16 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A lifetime of caring: Dimensions and dynamics in late-life close relationships AN - 61582524; 200704645 AB - This review of research on close relationships in old age is informed by principles of life span developmental psychology and life course theory in sociology. It begins with an elaboration of life span and life course concepts as applied to relationships and an analysis of the multiple forms that caring can take. The discussion continues with presentation of research on the effects of sociohistorical contexts on relationships in old age and studies of the effects of personal development and life events on relationships as well. A section examining problems in late-life close relationships is followed by examples of new directions for research on the intersections of personal development and close relationships. Figures, References. Adapted from the source document. JF - Personal Relationships AU - Blieszner, Rosemary AD - aVirginia Polytechnic Institute and State University Rosemary Blieszner, Alumni Distinguished Professor, is a Professor of Gerontology and Family Studies in the Department of Human Development and Associate Director of the Center for Gerontology at Virginia Polytechnic Institute and State University, Blacksburg. She received her Ph.D. from the Pennsylvania State University in Human Development-Family Studies with a major concentration in adult development and aging and a minor in sociology/social psychology. Her doctoral education was supported by the U. S. Administration on Aging and the National Institute on Aging. Her research, funded by the U. S. Administration on Aging, U. S. Departments of Health and Human Services and Agriculture, AARP Andrus Foundation, Alzheimer's Association, Virginia Tech ASPIRES Program, Virginia Tech Women's Research Institute, and Virginia Tech Educational Foundation, focuses on family and friend relationships, life events, and psycholog Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1 EP - 18 PB - Blackwell Publishing, Malden MA VL - 13 IS - 1 SN - 1350-4126, 1350-4126 KW - Friendship KW - Life History KW - Interpersonal Relations KW - Elderly KW - Life Events KW - article KW - 0665: complex organization; social network analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61582524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personal+Relationships&rft.atitle=A+lifetime+of+caring%3A+Dimensions+and+dynamics+in+late-life+close+relationships&rft.au=Blieszner%2C+Rosemary&rft.aulast=Blieszner&rft.aufirst=Rosemary&rft.date=2006-03-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Personal+Relationships&rft.issn=13504126&rft_id=info:doi/10.1111%2Fj.1475-6811.2006.00101.x LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PRRLEY N1 - SubjectsTermNotLitGenreText - Life Events; Life History; Elderly; Friendship; Interpersonal Relations DO - http://dx.doi.org/10.1111/j.1475-6811.2006.00101.x ER - TY - JOUR T1 - Untangling the Web: A Close Look at Diagnosis Disclosure among HIV-Infected Adolescents AN - 57214640; 200613744 AB - As children living with human immunodeficiency virus (HIV) survive into adolescence & young adulthood, attention to the relationship of diagnosis disclosure to psychological functioning, interpersonal relationships, & HIV prevention is needed. This exploratory study describes the level of adolescents' diagnosis disclosure to family, friends, & potential sexual partners, & the relationship between disclosure & psychosocial variables. 2 Tables, 10 References. [Copyright 2006 The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wiener, Lori S AU - Battles, Haven B AD - National Cancer Instit, Bethesda, MD wienerl@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 307 EP - 309 PB - Elsevier, New York NY VL - 38 IS - 3 SN - 1054-139X, 1054-139X KW - HIV-positive adolescents KW - Diagnosis disclosure KW - Posttraumatic stress symptoms KW - Psychological distress KW - Interpersonal relationships KW - Young adults KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57214640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Mental+Health&rft.atitle=Treatment+of+borderline+personality+disorder+with+schizotypal+traits&rft.au=Maffei%2C+Cesare&rft.aulast=Maffei&rft.aufirst=Cesare&rft.date=2010-08-01&rft.volume=4&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Personality+and+Mental+Health&rft.issn=19328621&rft_id=info:doi/10.1002%2Fpmh.136 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - HIV; Young adults; Interpersonal relationships DO - http://dx.doi.org/10.1016/j.jadohealth.2005.03.024 ER - TY - JOUR T1 - Maturing Out of Alcohol Dependence: The Impact of Transitional Life Events AN - 57203510; 200608254 AB - Objective: The purpose of this study was to investigate the effects of transitional life events related to education, employment, & family formation on the likelihood of recovery from alcohol dependence as defined by the Diagnostic & Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), distinguishing the short- & long-term effects of these events & potential effect modification by treatment history, gender, & severity of dependence. Method: This analysis is based on data from the Wave 1 2001-2002 National Epidemiologic Survey on Alcohol & Related Conditions (NESARC), a cross-sectional, retrospective survey of a nationally representative sample of U.S. adults 18 years of age & older. The analytic sample consisted of 4,422 individuals with prior-to-past-year (PPY) onset of DSM-IV alcohol dependence. Time-dependent proportional hazards models were used to estimate the effects of completing school, starting full-time work, getting married, becoming separated/divorced/widowed, & becoming a parent on the outcomes of nonabstinent recovery (NR; e.g., low-risk asymptomatic drinking) & abstinent recovery (AR). Results: Entry into & exit from a first marriage each increased the likelihood of NR during the first 3 years after those events occurred (hazard rate ratio [HRRI = 1.37 & 1.76, respectively). However, individuals who were still dependent 3 or more years after those events occurred had a decreased likelihood of subsequent NR (HRR = 0.70 for both events), as did those who were still dependent 3 or more years after completing schooling (HRR = 0.54). The likelihood of AR was more than doubled in the 3 years after first becoming a parent (HRR = 2.22) but was decreased among individuals still dependent 3 or more years after starting full-time work. For the outcome of NR, all of the negative effects associated with still being dependent 3 or more years after the occurrence of key life events were more strongly negative among individuals with less severe eases of dependence. Conclusions: Transitional life events demonstrate many effects on recovery, including both direct effects consistent with role socialization & associations more reflective of selectivity than causation. Taken as a whole, these events appear to contribute to (but by no means fully explain) the high rates of recovery from alcohol dependence that have been observed even in the absence of treatment. 3 Tables, 45 References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - Dawson, Deborah A AU - Grant, Bridget F AU - Stinson, Frederick S AU - Chou, Patricia S AD - Laboratory Epidemiology & Biometry, Division Intramural Clinical & Biological Research, National Instit Alco ddawson@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 195 EP - 203 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 67 IS - 2 SN - 0096-882X, 0096-882X KW - Education KW - Alcohol Dependence KW - Family Development KW - Life Events KW - Employment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57203510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Maturing+Out+of+Alcohol+Dependence%3A+The+Impact+of+Transitional+Life+Events&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BStinson%2C+Frederick+S%3BChou%2C+Patricia+S&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2006-03-01&rft.volume=67&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Alcohol Dependence; Life Events; Education; Employment; Family Development ER - TY - JOUR T1 - Triadic Model of the Neurobioglogy of Motivated Behavior in Adolescence AN - 57175071; 200608394 AB - Background. Risk-taking behavior is a major cause of morbidity & mortality in adolescence. In the context of decision theory & motivated (goal-directed) behavior, risk-taking reflects a pattern of decision-making that favors the selection of courses of action with uncertain & possibly harmful consequences. We present a triadic, neuroscience systems-based model of adolescent decision-making. Method. We review the functional role & neurodevelopmental findings of three key structures in the control of motivated behavior, i.e. amygdala, nucleus accumbens, & medial/ventral prefrontal cortex. We adopt a cognitive neuroscience approach to motivated behavior that uses a temporal fragmentation of a generic motivated action. Predictions about the relative contributions of the triadic nodes to the three stages of a motivated action during adolescence are proposed. Results. The propensity during adolescence for reward/novelty seeking in the face of uncertainty or potential harm might be explained by a strong reward system (nucleus accumbens), a weak harm-avoidant system (amygdala), &/or an inefficient supervisory system (medial/ventral prefrontal cortex). Perturbations in these systems may contribute to the expression of psychopathology, illustrated here with depression & anxiety. Conclusions. A triadic model, integrated in a temporally organized map of motivated behavior, can provide a helpful framework that suggests specific hypotheses of neural bases of typical & atypical adolescent behavior. 2 Figures, 151 References. Adapted from the source document. JF - Psychological Medicine AU - Ernst, Monique AU - Pine, Daniel S AU - Hardin, Michael AD - Section Developmental & Affective Neuroscience, Mood & Anxiety Disorders Program, National Instit Mental Hea ernstm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 299 EP - 312 PB - Cambridge U Press, UK VL - 36 IS - 3 SN - 0033-2917, 0033-2917 KW - Systemic models KW - Decision making KW - Motivation KW - Neurobiology KW - Risk taking KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57175071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Triadic+Model+of+the+Neurobioglogy+of+Motivated+Behavior+in+Adolescence&rft.au=Ernst%2C+Monique%3BPine%2C+Daniel+S%3BHardin%2C+Michael&rft.aulast=Ernst&rft.aufirst=Monique&rft.date=2006-03-01&rft.volume=36&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291705005891 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Adolescents; Decision making; Systemic models; Neurobiology; Motivation; Risk taking DO - http://dx.doi.org/10.1017/S0033291705005891 ER - TY - JOUR T1 - What Do Two-Year-Old Understand about Hidden-Object Events? AN - 57161076; 200609113 AB - Preferential-looking studies suggest that by 2 months of age, infants may have knowledge about some object properties, such as solidity. Manual search studies of toddlers examining these same concepts, however, have failed to provide evidence for the same understanding. Investigators have recently attempted to reconcile this disparity but failed to control for the visual novelty of test outcomes. The current design corrected this problem & also tested toddlers' predictions of the object's location. The task involved the same events & apparatus that have been used in manual search tasks but used looking as the dependent measure. Children looked longer when an agent opened the correct door & found no ball than when an incorrect door was opened to reveal no ball. A 2nd experiment indicated that children's preferential-looking performance did not differ from that in manual search tasks simply because additional response time had been allowed to respond. Previous comparisons of looking versus reaching tested children's postdiction response to an object in an unexpected location, but these findings indicate that toddlers can predict where the object should be. 4 Figures, 37 References. [Copyright 2006 American Psychological Association] JF - Developmental Psychology AU - Mash, Clay AU - Novak, Elizabeth AU - Berthier, Neil E AU - Keen, Rachel AD - NICHD Section Child & Family Research, Bethesda, MD mashc@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 263 EP - 271 PB - American Psychological Association, Washington DC VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - reasoning, manual search, toddlers, development KW - Reasoning KW - Hidden objects KW - Development KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57161076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Psychology&rft.atitle=What+Do+Two-Year-Old+Understand+about+Hidden-Object+Events%3F&rft.au=Mash%2C+Clay%3BNovak%2C+Elizabeth%3BBerthier%2C+Neil+E%3BKeen%2C+Rachel&rft.aulast=Mash&rft.aufirst=Clay&rft.date=2006-03-01&rft.volume=42&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Developmental+Psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.42.2.263 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - DEVPA9 N1 - SubjectsTermNotLitGenreText - Children; Hidden objects; Reasoning; Development DO - http://dx.doi.org/10.1037/0012-1649.42.2.263 ER - TY - JOUR T1 - Reward and Punishment Sensitivity in Shy and Non-Shy Adults: Relations between Social and Motivated Behavior AN - 57150046; 200606611 AB - Few studies have examined underlying mechanisms linking social behavior, motivated behavior, & reward & punishment systems. The current study was designed to investigate these mechanisms by examining responses to both rewarding & punishing non-social stimuli in shy & non-shy adults. Ninety-three participants, comprising three social behavior groups (Shy, Non-shy, Control) completed the Monetary Incentive Delay task. Consistent with previous research, all participants were sensitive to incentive manipulations. There were also significant individual differences in response. Non-shy participants demonstrated sensitivity to both reward & punishment stimuli, & behavior indicative of high levels of arousal in approach motivation. Shy individuals demonstrated a large discrepancy in sensitivity to reward compared to punishment, with this discrepancy being driven by enhanced sensitivity to reward. Their behavior suggested conflict generated by increased arousal in both approach & withdrawal motivation systems. Current findings contribute to theoretical accounts of relations between social behavior & behavior modulated by reward & punishment. These findings carry implications for the study of psychopathology & neuroimaging research designed to examine relationships between social behavior, motivated behavior, & underlying reward & punishment systems. 3 Tables, 3 Figures, 42 References. [Copyright 2005 Elsevier Ltd.] JF - Personality and Individual Differences AU - Hardin, Michael G AU - Perez-Edgar, Koraly AU - Guyer, Amanda E AU - Pine, Daniel S AU - Fox, Nathan A AU - Ernst, Monique AD - Section Development & Affective Neuroscience, National Instit Mental Health, NIH/DHHS, Bethesda, MD hardinm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 699 EP - 711 PB - Elsevier, UK VL - 40 IS - 4 SN - 0191-8869, 0191-8869 KW - Motivation KW - Reward KW - Punishment KW - Social behavior KW - Shyness KW - Anxiety KW - Behavioral inhibition KW - Inhibited behaviour KW - Social behaviour KW - Extrinsic motivation KW - Incentives KW - Shy people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57150046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Individual+Differences&rft.atitle=Reward+and+Punishment+Sensitivity+in+Shy+and+Non-Shy+Adults%3A+Relations+between+Social+and+Motivated+Behavior&rft.au=Hardin%2C+Michael+G%3BPerez-Edgar%2C+Koraly%3BGuyer%2C+Amanda+E%3BPine%2C+Daniel+S%3BFox%2C+Nathan+A%3BErnst%2C+Monique&rft.aulast=Hardin&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=40&rft.issue=4&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Personality+and+Individual+Differences&rft.issn=01918869&rft_id=info:doi/10.1016%2Fj.paid.2005.08.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PEIDD9 N1 - SubjectsTermNotLitGenreText - Incentives; Extrinsic motivation; Shy people; Punishment; Social behaviour; Inhibited behaviour DO - http://dx.doi.org/10.1016/j.paid.2005.08.010 ER - TY - JOUR T1 - Relationship between Age and Aspects of Depression: Consistency and Reliability across Two Longitudinal Studies AN - 57072159; 200618686 AB - In this study, the authors examined cross-sectional & longitudinal age & gender differences in each of the Center for Epidemiological Studies Depression Scale's 4 subscales of depressive symptomatology. Two independent studies (Sample 1 = 2,076; Sample 2 = 943) were used for purposes of establishing stability of findings. Results indicate a reasonable degree of stability among adults under 70 years of age. However, there were significant age-related increases in somatic symptoms & lack of well-being after approximately 70 years of age, whereas symptoms related to depressed affect & interpersonal problems remained stable. Notably, depressive affect symptoms remained stable given significant age-related somatic changes. The addition of comorbid physical illness to the analysis did not reduce the association between age & depressive symptoms, indicating that part of the association was not substantially accounted for by physical health. Tables, Figures, References. [Copyright 2006 American Psychological Association.] JF - Psychology and Aging AU - Nguyen, Ha T AU - Zonderman, Alan B AD - Gerontology Research Center, National Instit Aging, Baltimore, MD nguyenha@grc.nia.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 119 EP - 126 PB - American Psychological Association, Washington DC VL - 21 IS - 1 SN - 0882-7974, 0882-7974 KW - age, depression, CES-D, subscales KW - Age KW - Depression KW - Somatic symptoms KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57072159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Relationship+between+Age+and+Aspects+of+Depression%3A+Consistency+and+Reliability+across+Two+Longitudinal+Studies&rft.au=Nguyen%2C+Ha+T%3BZonderman%2C+Alan+B&rft.aulast=Nguyen&rft.aufirst=Ha&rft.date=2006-03-01&rft.volume=21&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2F0882-7974.21.1.119 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Age; Depression; Gender differences; Somatic symptoms DO - http://dx.doi.org/10.1037/0882-7974.21.1.119 ER - TY - CPAPER T1 - A Model of Neurovisceral Integration: An Overview with Implications for Health and Disease T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39931422; 4156909 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Thayer, Julian F Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Integration KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=A+Model+of+Neurovisceral+Integration%3A+An+Overview+with+Implications+for+Health+and+Disease&rft.au=Thayer%2C+Julian+F&rft.aulast=Thayer&rft.aufirst=Julian&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Neural Network of Mirror Neuron System and Mentalizing in Alexithymia T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39929349; 4157024 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Moriguchi, Yoshiya AU - Ohnishi, Takashi AU - Maeda, Motonari AU - Komaki, Gen Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Artificial intelligence KW - Neural networks KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=The+Neural+Network+of+Mirror+Neuron+System+and+Mentalizing+in+Alexithymia&rft.au=Moriguchi%2C+Yoshiya%3BOhnishi%2C+Takashi%3BMaeda%2C+Motonari%3BKomaki%2C+Gen&rft.aulast=Moriguchi&rft.aufirst=Yoshiya&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health, Diurnal Rhythm and Awakening Cortisol Response in Midterm and Late Pregnant Women T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39922463; 4157167 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Nagamine, Mitsue AU - Saito, Satoru AU - Okabayashi, Hideki AU - Kim, Yoshiharu Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Diurnal variations KW - Hydrocortisone KW - Rhythms KW - Circadian rhythms KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=Mental+Health%2C+Diurnal+Rhythm+and+Awakening+Cortisol+Response+in+Midterm+and+Late+Pregnant+Women&rft.au=Nagamine%2C+Mitsue%3BSaito%2C+Satoru%3BOkabayashi%2C+Hideki%3BKim%2C+Yoshiharu&rft.aulast=Nagamine&rft.aufirst=Mitsue&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Aspects of Alexithymia: A Japanese Community Based Study T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39922072; 4157039 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Komaki, Gen AU - Moriguchi, Yoshiya AU - Maeda, Motonari Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Japan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=Developmental+Aspects+of+Alexithymia%3A+A+Japanese+Community+Based+Study&rft.au=Komaki%2C+Gen%3BMoriguchi%2C+Yoshiya%3BMaeda%2C+Motonari&rft.aulast=Komaki&rft.aufirst=Gen&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Personality and subjective well-being in orangutans (Pongo pygmaeus and pongo abelii) AN - 37721397; 3265037 AB - Orangutans (Pongo pygmaeus and Pongo abelii) are semisolitary apes and, among the great apes, the most distantly related to humans. Raters assessed 152 orangutans on 48 personality descriptors; 140 of these orangutans were also rated on a subjective well-being questionnaire. Principal-components analysis yielded 5 reliable personality factors: Extraversion, Dominance, Neuroticism, Agreeableness, and Intellect. The athors found no factor analogous to human Conscientiousness. Among the orangutans rated on all 48 personality descriptors and the subjective well-being questionnaire, Extraversion, Agreeableness, and low Neuroticism were related to subjective well-being. These findings suggest that analogues of human, chimpanzee, and orangutan personality domains existed in a common ape ancestor. Reprinted by permission of the American Psychological Association JF - Journal of personality and social psychology AU - Weiss, Alexander AU - King, James E AD - National Institutes of Health ; University of Arizona Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 501 EP - 511 VL - 90 IS - 3 SN - 0022-3514, 0022-3514 KW - Sociology KW - Animals KW - Social psychology KW - Psychology KW - Well-being KW - Personality KW - Orang-utans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37721397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Personality+and+subjective+well-being+in+orangutans+%28Pongo+pygmaeus+and+pongo+abelii%29&rft.au=Weiss%2C+Alexander%3BKing%2C+James+E&rft.aulast=Weiss&rft.aufirst=Alexander&rft.date=2006-03-01&rft.volume=90&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2F0022-3514.90.3.501 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 13530 13521; 8983 10148; 1046; 11901 10404; 10404 DO - http://dx.doi.org/10.1037/0022-3514.90.3.501 ER - TY - JOUR T1 - Depression, self-esteem, and anger in emerging adulthood: seven-year trajectories AN - 37715686; 3261998 AB - This study used a school-based community sample (N = 920) to examine trajectories of depressive symptoms, self-esteem, and expressed anger in the critical years of emerging adulthood (ages 18-25). Using data from 5 waves, the authors discovered that multilevel models indicated that, on average, depressive symptoms and expressed anger declined, whereas self-esteem increased. Between-persons predictors of variability in trajectories included gender (gender gaps in depressive symptoms and self-esteem narrowed), parents' education, and conflict with parents (depressive symptoms and expressed anger improved fastest in participants with highly educated parents and in those with higher conflict). Across time, increases in social support and marriage were associated with increased psychological well-being, whereas longer periods of unemployment were connected with higher depression and lower self-esteem. Emerging adulthood is a time of improving psychological well-being, but individual trajectories depend on specific individual and family characteristics as well as role changes. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Galambos, Nancy L AU - Barker, Erin T AU - Krahn, Harvey J AD - University of Alberta ; National Institute of Child Health and Human Development Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 350 EP - 365 VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - Sociology KW - Survey analysis KW - Depression KW - Social support KW - Adulthood KW - Time series KW - Parent-child relations KW - Sample surveys KW - Developmental psychology KW - Youth KW - Anger KW - Self-esteem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37715686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prison+Journal&rft.atitle=Whatever+is+next+after+the+prison-building+boom+will+be+next+in+Texas&rft.au=Fabelo%2C+Tony&rft.aulast=Fabelo&rft.aufirst=Tony&rft.date=1996-12-01&rft.volume=76&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=The+Prison+Journal&rft.issn=00328855&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 3439 4196 7951 6220 7954; 11473 11442 6191; 1022 4196; 13779 652 5676 646 6091; 12759 12228 10919; 11253 12429; 12426 3279 971 3286; 9178 4777 6093 6823; 11938 11949 13521; 602 652 5676 646 6091 DO - http://dx.doi.org/10.1037/0012-1649.42.2.350 ER - TY - JOUR T1 - What do two-year-olds understand about hidden-object events? AN - 37711606; 3261990 AB - Preferential-looking studies suggest that by 2 months of age, infants may have knowledge about some object properties, such as solidity. Manual search studies of toddlers examining these same concepts, however, have failed to provide evidence for the same understanding. Investigators have recently attempted to reconcile this disparity but failed to control for the visual novelty of test outcomes. The current design corrected this problem and also tested toddlers' predictions of the object's location. The task involved the same events and apparatus that have been used in manual search tasks but used looking as the dependent measure. Children looked longer when an agent opened the correct door and found no ball than when an incorrect door was opened to reveal no ball. A 2nd experiment indicated that children's preferential-looking performance did not differ from that in manual search tasks simply because additional response time had been allowed to respond. Previous comparisons of looking versus reaching tested children's postdiction response to an object in an unexpected location, but these findings indicate that toddlers can predict where the object should be. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Mash, Clay AU - Novak, Elizabeth AU - Berthier, Neil E AU - Keen, Rachel AD - National Institute of Child Health and Human Development ; University of Massachusetts Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 263 EP - 271 VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - Sociology KW - Reasoning KW - Childhood KW - Regression analysis KW - Empirical research KW - Developmental psychology KW - Cognition KW - Object UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37711606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=What+do+two-year-olds+understand+about+hidden-object+events%3F&rft.au=Mash%2C+Clay%3BNovak%2C+Elizabeth%3BBerthier%2C+Neil+E%3BKeen%2C+Rachel&rft.aulast=Mash&rft.aufirst=Clay&rft.date=2006-03-01&rft.volume=42&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.42.2.263 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 8824; 2449 10404; 4200 10902; 2211 652 5676 646 6091 2212; 10643 10642 2688 2449 10404; 10739 12228 10919 DO - http://dx.doi.org/10.1037/0012-1649.42.2.263 ER - TY - JOUR T1 - Atrial Fibrillation among African Americans, Hispanics and Caucasians: Clinical Features and Outcomes from the AFFIRM Trial AN - 214046315; 16573295 AB - The Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study concluded that rate control with anticoagulation was equivalent overall to rhythm control with cardioversion for long-term survival and that anticoagulation reduced the risk of stroke. We compared baseline and follow-up data for three ethnic groups: Caucasians (n=3,599), African Americans (n=265) and Hispanics (n=132). Caucasians were older and more likely male, African Americans were more likely female and hypertensive, and Hispanics had higher prevalence of cardiomyopathy. Survival was better for rate control than rhythm control in Caucasians, equivalent in African Americans and better for rhythm control in Hispanics. Outcomes may be influenced by differential baseline characteristics, but low numbers of African Americans and Hispanics warrant caution in data interpretation. The AFFIRM study compared a rate-control strategy to a rhythm-control strategy for the treatment of atrial fibrillation (AF) in patients at high risk for stroke or death. It concluded that the rhythm-control strategy offered no survival advantage, and it also confirmed the value of anticoagulation to prevent complications of AF. Data have not previously been available for specific racial ethnic populations. We compared baseline and follow-up data for the patients randomized to rate-control versus rhythm-control in three population groups-Caucasian, African-American and Hispanic. Among 4,060 total patients, 3,599 were Caucasian, 265 were African-American and 132 were Hispanic. At baseline, Caucasians were older and had a higher percentage of males, normal ejection fractions, AF as their only cardiac diagnosis, a prior antiarrhythmic drug failure and less congestive heart failure. African Americans were more likely to be female, had more hypertension and qualified for the study with a first episode of AF, compared to Caucasians. Hispanics had more cardiomyopathy at baseline than Caucasians. Overall survival in Caucasians at five years for the rate-control and rhythm-control groups was 78.9% vs. 76.4%, respectively (p=0.04); for African Americans, 79.0% vs. 69.4% (p=0.22); and for Hispanics, 66.5% vs. 83.9% (p=0.01). Overall, survival was not different between the three populations. However, lower rates of event-free survival were recorded for Hispanics and for African Americans (p=0.0182). Different survival rates were found for rate-control versus rhythm-control in African-American and Hispanic patients, compared to Caucasian. These findings may be influenced by differences in baseline characteristics, but must be interpreted with caution because of the small sample sizes for African-American and Hispanic participants. JF - Journal of the National Medical Association AU - Bush, David AU - Martin, Lisa W AU - Leman, Robert AU - Chandler, Mary AU - Haywood, L Julian Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 330 EP - 9 CY - Washington PB - National Medical Association VL - 98 IS - 3 SN - 00279684 KW - Medical Sciences KW - Anticoagulants KW - Atrial Fibrillation -- mortality KW - Electric Countershock KW - Survival Rate KW - Anticoagulants -- therapeutic use KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Hispanic Americans KW - European Continental Ancestry Group KW - African Americans KW - Atrial Fibrillation -- therapy KW - Atrial Fibrillation -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/214046315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Medical+Association&rft.atitle=Atrial+Fibrillation+among+African+Americans%2C+Hispanics+and+Caucasians%3A+Clinical+Features+and+Outcomes+from+the+AFFIRM+Trial&rft.au=Bush%2C+David%3BMartin%2C+Lisa+W%3BLeman%2C+Robert%3BChandler%2C+Mary%3BHaywood%2C+L+Julian&rft.aulast=Bush&rft.aufirst=David&rft.date=2006-03-01&rft.volume=98&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Medical+Association&rft.issn=00279684&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright National Medical Association Mar 2006 N1 - Last updated - 2014-04-30 N1 - CODEN - JNMAAE ER - TY - JOUR T1 - Imaging genomics applied to anxiety, stress response, and resiliency AN - 21220615; 11280690 AB - Anxiety and stress response/resiliency are heritable traits central to the etiology of multiple psychiatric diseases, but efforts to identify genetic variation influencing this broad domain of neurobiological function are hampered by the coarseness of the phenotypic measures and the effects of environmental factors. Neuroimaging offers a powerful approach for assessing functional neuronal activity. Neurophysiological measures can serve as intermediate phenotypes more directly linked to small gene effects, compared with behavioral end points of neural dysfunction. Imaging genomics is a relatively new research area that is concerned with linking functional gene variants and brain information processing. Here, we will focus on processes affected by anxiety and stress. Neuroimaging has been combined with genetic analysis to reveal genetic effects of functional variants of the serotonin transporter (5-HTT) and catechol-O-methyltransferase (COMT) genes on brain response to stressful stimuli. The low-expressing allele of the 5-HTT promoter polymorphism (HTTLPR) is associated with anxiety and with greater amygdala and other regional responses to emotional. The COMT Met158 allele leads to lower COMT activity and has also been associated with anxiety, and the effect of this gene is apparently additive with HTTLPR. Individuals with Met158 genotypes are more sensitive to pain stress and, as shown by C Carfentanil imaging, have diminished ability to upregulate opioid release after pain/stress. These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety. JF - Neuroinformatics AU - Xu, Ke AU - Ernst, Monique AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, 5625 Fishers Lane, Room 3S32, 20852 Rockville, MD, ke@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 51 EP - 64 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 4 IS - 1 SN - 1539-2791, 1539-2791 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Emotions KW - Neuroimaging KW - Etiology KW - Anxiety KW - Gene polymorphism KW - Genetic analysis KW - Genetic diversity KW - Stress KW - Pain KW - Environmental factors KW - Mental disorders KW - Catechol O-methyltransferase KW - Information processing KW - Amygdala KW - Opioids KW - Bioinformatics KW - genomics KW - Serotonin transporter KW - G 07880:Human Genetics KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=Imaging+genomics+applied+to+anxiety%2C+stress+response%2C+and+resiliency&rft.au=Xu%2C+Ke%3BErnst%2C+Monique%3BGoldman%2C+David&rft.aulast=Xu&rft.aufirst=Ke&rft.date=2006-03-01&rft.volume=4&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1385%2FNI%3A4%3A1%3A51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Emotions; Etiology; Neuroimaging; Anxiety; Gene polymorphism; Genetic analysis; Stress; Genetic diversity; Pain; Environmental factors; Mental disorders; Catechol O-methyltransferase; Information processing; Opioids; Amygdala; genomics; Bioinformatics; Serotonin transporter DO - http://dx.doi.org/10.1385/NI:4:1:51 ER - TY - JOUR T1 - Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI AN - 21152271; 11177673 AB - The availability of structural information on glycosyltransferases is beginning to make structure-based reengineering of these enzymes possible. Mutant glycosyltransferases have been generated that can transfer a sugar residue with a chemically reactive unique functional group to a sugar moiety of glycoproteins, glycolipids, and proteoglycans (glyco-conjugates). The presence of modified sugar moiety on a glycoprotein makes it possible to link bioactive molecules via modified glycan chains, thereby assisting in the assembly of bionanoparticles that are useful for developing the targeted drug delivery system and contrast agents for magnetic resonance imaging. The reengineered recombinant glycosyltransferases also make it possible to (1) remodel the oligosaccharide chains of glycoprotein drugs, and (2) synthesize oligosaccharides for vaccine development. JF - AAPS Journal AU - Qasba, Pradman K AU - Ramakrishnan, Boopathy AU - Boeggeman, Elizabeth AD - Basic Research Program, SAIC-Frederick Inc, Frederick, MD, qasba@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - E190 EP - E195 PB - American Association of Pharmaceutical Scientists VL - 8 IS - 1 SN - 1550-7416, 1550-7416 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Sugar KW - oligosaccharides KW - Magnetic resonance imaging KW - Enzymes KW - Drug development KW - Polysaccharides KW - Glycosyltransferase KW - Glycolipids KW - Proteoglycans KW - Contrast media KW - Vaccines KW - Glycoproteins KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21152271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Mutant+glycosyltransferases+assist+in+the+development+of+a+targeted+drug+delivery+system+and+contrast+agents+for+MRI&rft.au=Qasba%2C+Pradman+K%3BRamakrishnan%2C+Boopathy%3BBoeggeman%2C+Elizabeth&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2006-03-01&rft.volume=8&rft.issue=1&rft.spage=E190&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Faapsj080123 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sugar; Drug delivery; oligosaccharides; Magnetic resonance imaging; Enzymes; Drug development; Polysaccharides; Glycosyltransferase; Proteoglycans; Glycolipids; Contrast media; Glycoproteins; Vaccines DO - http://dx.doi.org/10.1208/aapsj080123 ER - TY - JOUR T1 - A new method of wet scanning electron microscopy for the analysis of myelination in EAE mouse model of multiple sclerosis AN - 21047930; 6676083 AB - Development of effective therapies for multiple sclerosis (MS) is dependent on the advancement of improved tools for evaluation of progression of this disease in animal models. We present a novel technique utilizing scanning electron microscopy (SEM) for imaging wet biological specimens thus enabling rapid and high-resolution imaging of myelin in mouse spinal cord (SC). We demonstrate the advantages of using the wet SEM technique to image myelin in a murine model of MS, experimental autoimmune encephalomyelitis (EAE) induced in the Biozzi (antibody-high) mouse, by sensitization with spinal cord homogenate (SCH) in adjuvant. Our studies show that the methodology allows easy identification of normal and pathological components with great clarity, which is then correlated with light microscopy (LM) and validated thereby. Furthermore, we demonstrate gold immunolabeling of specific epitopes. We conclude that the new technique provides a quick, accurate, and detailed structural evaluation of the SC that can be applied to advance the research of MS. JF - Experimental and Toxicologic Pathology AU - Nyska, Abraham AU - Horowitz, Miri AU - Anaby, Debbie AU - Sabban, Alon AU - Leizerman, Ilit AU - Blaugrund, Eran AU - Mayk, Adi AU - Behar, Vered AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, NC, USA, anyska@bezeqint.net Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 291 EP - 297 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 57 IS - 4 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Wet scanning electron microscopy KW - Myelin KW - Multiple sclerosis KW - Scanning electron microscopy KW - Spinal cord KW - Animal models KW - Gold KW - Adjuvants KW - Experimental allergic encephalomyelitis KW - Myelination KW - imaging KW - Epitopes KW - N3 11021:Neuroimaging techniques KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21047930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=A+new+method+of+wet+scanning+electron+microscopy+for+the+analysis+of+myelination+in+EAE+mouse+model+of+multiple+sclerosis&rft.au=Nyska%2C+Abraham%3BHorowitz%2C+Miri%3BAnaby%2C+Debbie%3BSabban%2C+Alon%3BLeizerman%2C+Ilit%3BBlaugrund%2C+Eran%3BMayk%2C+Adi%3BBehar%2C+Vered&rft.aulast=Nyska&rft.aufirst=Abraham&rft.date=2006-03-01&rft.volume=57&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2005.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Scanning electron microscopy; Spinal cord; Multiple sclerosis; Animal models; Gold; Adjuvants; Myelination; Experimental allergic encephalomyelitis; imaging; Epitopes DO - http://dx.doi.org/10.1016/j.etp.2005.11.001 ER - TY - JOUR T1 - Interaction of Zwitterionic Penicillins with the OmpF Channel Facilitates Their Translocation AN - 20987494; 7453451 AB - To study translocation of beta -lactam antibiotics of different size and charge across the outer bacterial membrane, we combine an analysis of ion currents through single trimeric outer membrane protein F (OmpF) porins in planar lipid bilayers with molecular dynamics simulations. Because the size of penicillin molecules is close to the size of the narrowest part of the OmpF pore, penicillins occlude the pore during their translocation. Favorably interacting penicillins cause time-resolvable transient blockages of the small-ion current through the channel and thereby provide information about their dynamics within the pore. Analyzing these random fluctuations, we find that ampicillin and amoxicillin have a relatively high affinity for OmpF. In contrast, no or only a weak interaction is detected for carbenicillin, azlocillin, and piperacillin. Molecular dynamics simulations suggest a possible pathway of these drugs through the OmpF channel and rationalize our experimental findings. For zwitterionic ampicillin and amoxicillin, we identify a region of binding sites near the narrowest part of the channel pore. Interactions with these sites partially compensate for the entropic cost of drug confinement by the channel. Whereas azlocillin and piperacillin are clearly too big to pass through the channel constriction, dianionic carbenicillin does not find an efficient binding region in the constriction zone. Carbenicillin's favorable interactions are limited to the extracellular vestibule. These observations confirm our earlier suggestion that a set of high-affinity sites at the narrowest part of the OmpF channel improves a drug's ability to cross the membrane via the pore. JF - Biophysical Journal AU - Danelon, Christophe AU - Nestorovich, Ekaterina M AU - Winterhalter, Mathias AU - Ceccarelli, Matteo AU - Bezrukov, Sergey M AD - Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, bezrukos@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1617 EP - 1627 PB - Biophysical Society, [mailto:ckenney@biophysics.org], [URL:http://www.biophysics.org/] VL - 90 IS - 5 SN - 0006-3495, 0006-3495 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - Lipid bilayers KW - Amoxicillin KW - outer membrane proteins KW - Channel pores KW - Porins KW - Ion currents KW - Ampicillin KW - Carbenicillin KW - Penicillin KW - Azlocillin KW - beta -Lactam antibiotics KW - Piperacillin KW - Drugs KW - Translocation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=Interaction+of+Zwitterionic+Penicillins+with+the+OmpF+Channel+Facilitates+Their+Translocation&rft.au=Danelon%2C+Christophe%3BNestorovich%2C+Ekaterina+M%3BWinterhalter%2C+Mathias%3BCeccarelli%2C+Matteo%3BBezrukov%2C+Sergey+M&rft.aulast=Danelon&rft.aufirst=Christophe&rft.date=2006-03-01&rft.volume=90&rft.issue=5&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Biophysical+Journal&rft.issn=00063495&rft_id=info:doi/10.1529%2Fbiophysj.105.075192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein transport; Amoxicillin; Lipid bilayers; outer membrane proteins; Channel pores; Porins; Ampicillin; Ion currents; Carbenicillin; Penicillin; Azlocillin; beta -Lactam antibiotics; Piperacillin; Translocation; Drugs DO - http://dx.doi.org/10.1529/biophysj.105.075192 ER - TY - JOUR T1 - A Factorial Trial Including Garlic Supplements Assesses Effect in Reducing Precancerous Gastric Lesions AN - 20871745; 6714680 AB - The Shandong Intervention Trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in Linqu County, Shandong Province, China, a region with high gastric cancer mortality rates and a prevalence in adults of Helicobacter pylori of similar to 67%. The 3 interventions were one-time treatment with amoxicillin and omeprazole for Helicobacter pylori infection, and long-term administration of a garlic supplement (aged garlic extract and steam-distilled garlic oil) and a vitamin supplement (vitamins E and C and selenium). This paper describes the design and initial findings on treatment compliance, completeness of follow-up data, and eradication of Helicobacter pylori. JF - Journal of Nutrition AU - Gail, Mitchell H AU - You, Wei-Cheng AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 and Beijing Institute of Cancer Research, Haidian District, Beijing, China 100036 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 813S EP - 815S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 3 SN - 0022-3166, 0022-3166 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Mortality KW - Amoxicillin KW - Data processing KW - Allium sativum KW - Infection KW - Oil KW - Selenium KW - Vitamin E KW - Dietary supplements KW - Vitamins KW - Gastric cancer KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20871745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=A+Factorial+Trial+Including+Garlic+Supplements+Assesses+Effect+in+Reducing+Precancerous+Gastric+Lesions&rft.au=Gail%2C+Mitchell+H%3BYou%2C+Wei-Cheng&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2006-03-01&rft.volume=136&rft.issue=3&rft.spage=813S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Oil; Selenium; Mortality; Amoxicillin; Vitamin E; Data processing; Vitamins; Dietary supplements; Infection; Gastric cancer; Helicobacter pylori; Allium sativum ER - TY - JOUR T1 - Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping AN - 20857786; 8368065 AB - There has been growing interest in using manganese-enhanced MRI (MEMRI) to detect neuronal activation, neural architecture, and neuronal connections. Usually Mn2+ produces a very wide range of T1 change. In particular, in neuronal tract tracing experiments the site of Mn2+ injection can have very short T1 while distant regions have small T1 reductions, primarily due to dilution of Mn2+. Most MEMRI studies use T1-weighted sequences, which can only give optimal contrast for a narrow range of T1 changes. To improve sensitivity to the full extent of Mn2+ concentrations and to optimize detection of low concentrations of Mn2+, a fast T1 mapping sequence based on the Look and Locker technique was implemented. Phantom studies demonstrated less than 6.5% error in T1 compared to more conventional T1 measurements. Using center-out segmented EPI, whole-brain 3D T1 maps with 200-m isotropic resolution were obtained in 2 h from rat brain. Mn2+ transport from the rat olfactory bulb through appropriate brain structures could be detected to the amygdala in individual animals. The method reliably detected less than 7% reductions in T1. With this quantitative imaging it should be possible to study more extensive pathways using MEMRI and decrease the dose of Mn2+ used. JF - Magnetic Resonance in Medicine AU - Chuang, Kai-Hsiang AU - Koretsky, Alan AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA, KoretskyA@ninds.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 604 EP - 611 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Neuroimaging KW - Magnetic resonance imaging KW - Brain KW - Olfactory bulb KW - Amygdala KW - N.M.R. KW - Manganese KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Improved+neuronal+tract+tracing+using+manganese+enhanced+magnetic+resonance+imaging+with+fast+T1+mapping&rft.au=Chuang%2C+Kai-Hsiang%3BKoretsky%2C+Alan&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2006-03-01&rft.volume=55&rft.issue=3&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Brain; Neuroimaging; N.M.R.; Amygdala; Brain mapping; Manganese; Olfactory bulb DO - http://dx.doi.org/10.1002/mrm.20797 ER - TY - JOUR T1 - Noninvasive measurement of myocardial tissue volume change during systolic contraction and diastolic relaxation in the canine left ventricle AN - 20855098; 8368050 AB - In coronary circulation the flow in epicardial arteries and veins is observed to be pulsatile and out of phase with each other. Theoretical considerations predict that this phenomenon extends to all levels of the vascular tree and leads to a cyclic fluctuation of regional tissue volume. Intramyocardial tissue volume change between end-systole and end-diastole was measured noninvasively with MRI in 10 closed-chest beagles. The displacement encoding with stimulated-echo technique was used to obtain pixel-by-pixel tissue displacement field between end-diastole and end-systole and vice versa in the midlevel left ventricle, from which the 3D strain matrix and volume changes were calculated. The volume change was between 0.8 - 0.5% (mean - STD) in the epicardial layer and 1.5 - 0.6% in the subendocardial layer of the left ventricle. Tissue volume fluctuation reflects the amount of arterial inflow in a heartbeat under the assumption that regional arterial inflow and venous outflow have little time overlap. The corresponding perfusion level was estimated to be from (1.0 - 0.6) ml/min/g in the epicardial layer to (1.7 - 0.6) ml/min/g in the subendocardial layer, in good agreement with microsphere measurements in the same dog model. The result supports the notion of high arterial resistance at the microvascular level from intramyocardial pressure during systole. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Rodriguez, Ignacio AU - Ennis, Daniel B AU - Wen, Han AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, wenh@nhlbi.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 484 EP - 490 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Microvasculature KW - Perfusion KW - Arteries KW - Magnetic resonance imaging KW - Models KW - Ventricle KW - Veins KW - microspheres KW - N.M.R. KW - Pressure KW - Vascular system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Noninvasive+measurement+of+myocardial+tissue+volume+change+during+systolic+contraction+and+diastolic+relaxation+in+the+canine+left+ventricle&rft.au=Rodriguez%2C+Ignacio%3BEnnis%2C+Daniel+B%3BWen%2C+Han&rft.aulast=Rodriguez&rft.aufirst=Ignacio&rft.date=2006-03-01&rft.volume=55&rft.issue=3&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ventricle; Models; N.M.R.; Veins; Heart; Pressure; Vascular system; Arteries; Perfusion; Magnetic resonance imaging; Microvasculature; microspheres DO - http://dx.doi.org/10.1002/mrm.20786 ER - TY - JOUR T1 - Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis AN - 20633677; 9360755 AB - The metastasis of prostate cancer cells to the bone marrow constitutes the major source of morbidity and mortality in prostate cancer. Studying this process has been hampered by the lack of preclinical models to evaluate novel therapeutics and to study the biology of the disease. One proposed model utilizes human fetal bone implants to serve as the target for prostate cancer cells injected via the tail vein. We employed this model to test the ability of zoledronic acid to prophylax and to treat bone metastases. To improve the rate of bone metastasis, we used two bone implants instead of one to evaluate the cell lines PC3 and PC3M, a more metastatic subline. For this purpose we generated the novel cell line PC3EGFPLuc, which can be used for luminescence and/or fluorescence imaging in vivo. We did not observe bone implant metastases in 52 mice, with 90 bone implants following tail vein injection of 1x106 PC3 or PC3M cells. Soft tissue lesions in the buttocks and hind limbs as well as cellular growth in the hindlimbs were observed via bioluminescence imaging. This evidence together with literature findings suggests that this model produces artifactual 'bone metastasis' lesions. JF - Oncology Reports AU - Singh, A S AU - MacPherson, G R AU - Price, D K AU - Schimel, D AU - Figg, W D AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 519 EP - 524 VL - 15 IS - 3 SN - 1021-335X, 1021-335X KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Mortality KW - Bone cancer KW - Zoledronic acid KW - Fluorescence KW - Bioluminescence KW - Animal models KW - Bone marrow KW - imaging KW - Morbidity KW - Fetuses KW - Metastases KW - Veins KW - Prostate cancer KW - Limbs KW - Bone implants KW - Luminescence KW - Soft tissues KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20633677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=Evaluation+of+human+fetal+bone+implants+in+SCID+mice+as+a+model+of+prostate+cancer+bone+metastasis&rft.au=Singh%2C+A+S%3BMacPherson%2C+G+R%3BPrice%2C+D+K%3BSchimel%2C+D%3BFigg%2C+W+D&rft.aulast=Singh&rft.aufirst=A&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Oncology+Reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bone cancer; Mortality; Fluorescence; Zoledronic acid; Bioluminescence; Bone marrow; Animal models; imaging; Fetuses; Morbidity; Metastases; Limbs; Prostate cancer; Veins; Bone implants; Soft tissues; Luminescence ER - TY - JOUR T1 - Surviving inside a macrophage: The many ways of Brucella AN - 20630603; 6681099 AB - Bacteria of the genus Brucella are intracellular pathogens capable of survival and replication within macrophages of mammalian hosts. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication. JF - Research in Microbiology AU - Celli, Jean AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT, 59840, USA, jcelli@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 93 EP - 98 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 157 IS - 2 SN - 0923-2508, 0923-2508 KW - Microbiology Abstracts B: Bacteriology KW - Brucella KW - Replication KW - Macrophage KW - Virulence factors KW - Permissivity Abstract + References KW - Macrophages KW - Cell survival KW - virulence factors KW - Reviews KW - Life cycle KW - Pathogens KW - Defense mechanisms KW - Organelles KW - J 02750:Phage-host interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20630603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Microbiology&rft.atitle=Surviving+inside+a+macrophage%3A+The+many+ways+of+Brucella&rft.au=Celli%2C+Jean&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2006-03-01&rft.volume=157&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Research+in+Microbiology&rft.issn=09232508&rft_id=info:doi/10.1016%2Fj.resmic.2005.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Macrophages; virulence factors; Replication; Reviews; Life cycle; Defense mechanisms; Pathogens; Organelles; Brucella DO - http://dx.doi.org/10.1016/j.resmic.2005.10.002 ER - TY - JOUR T1 - Intracellular cytokine optimization and standard operating procedure AN - 20529514; 7635944 AB - We describe here a method for optimizing the use of polychromatic flow cytometry (with up to 17 fluorochromes simultaneously) in surface and intracellular staining of human T lymphocytes. We will highlight and discuss how to procedurally optimize key steps in the experimental process before an intracellular cytokine staining assay protocol is finalized. These include but are not limited to the titration of monoclonal antibodies, use of a dead- cell discriminator and 'dump' channel, selection of a cytokine secretion inhibitor, selection of fixation and permeabilization reagents, and inclusion of compensation controls. Building on this basic protocol, we then establish a polychromatic assay designed to detect five separate functions of T lymphocytes (production of three cytokines and one chemokine, and degranulation) while simultaneously identifying multiple surface markers on the responding cells. JF - Nature Protocols AU - Lamoreaux, Laurie AU - Roederer, Mario AU - Koup, Richard Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1507 EP - 1516 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 1 IS - 3 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cytometry KW - Functional analysis KW - Immunological techniques KW - Flow cytometry KW - Chemokines KW - Monoclonal antibodies KW - Degranulation KW - Titration KW - Lymphocytes T KW - Cytokines KW - fluorochromes KW - Surface markers KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20529514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Intracellular+cytokine+optimization+and+standard+operating+procedure&rft.au=Lamoreaux%2C+Laurie%3BRoederer%2C+Mario%3BKoup%2C+Richard&rft.aulast=Lamoreaux&rft.aufirst=Laurie&rft.date=2006-03-01&rft.volume=1&rft.issue=3&rft.spage=1507&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2006.268 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Chemokines; Monoclonal antibodies; Degranulation; Titration; Lymphocytes T; Cytokines; fluorochromes; Surface markers DO - http://dx.doi.org/10.1038/nprot.2006.268 ER - TY - JOUR T1 - Curcumin is an Inhibitor of p300 Histone Acetylatransferase AN - 20234684; 8011386 AB - Histone acetyltransferases (HATs), and p300/CBP in particular, have been implicated in cancer cell growth and survival, and as such, HATs represent novel, therapeutically relevant molecular targets for drug development. In this study, we demonstrate that the small molecule natural product curcumin, whose medicinal properties have long been recognized in India and Southeast Asia, is a selective HAT inhibitor. Furthermore the data indicate that alpha , beta unsaturated carbonyl groups in the curcumin side chain function as Michael reaction sites and that the Michael reaction acceptor functionality of curcumin is required for its HAT-inhibitory activity. In cells, curcumin promoted proteasome-dependent degradation of p300 and the closely related CBP protein without affecting the HATs PCAF or GCN5. In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate. Radiolabeled curcumin formed a covalent association with p300, and tetrahydrocurcumin displayed no p300 inhibitory activity, consistent with a Michael reaction- dependent mechanism. Finally, curcumin was able to effectively block histone hyperacetylation in both PC3-M prostate cancer cells and peripheral blood lymphocytes induced by the histone deacetylase inhibitor MS-275. These data thus identify the medicinal natural product curcumin as a novel lead compound for development of possibly therapeutic, p300/CBP-specific HAT inhibitors. JF - Medicinal Chemistry AU - Marcu, Monica G AU - Jung, Yun-Jin AU - Lee, Sunmin AU - Chung, Eun-Joo AU - Lee, Min-Jung AU - Trepel, Jane AU - Neckers, Len AD - Urologic Oncology Branch and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 169 EP - 174 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 2 IS - 2 SN - 1573-4064, 1573-4064 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Curcumin KW - p300/CBP KW - acetylation KW - Michael reaction acceptor KW - Cell survival KW - Histone deacetylase KW - Data processing KW - Histone acetyltransferase KW - Peripheral blood KW - Drug development KW - natural products KW - Lymphocytes KW - Prostate cancer KW - CBP protein KW - Histone H3 KW - carbonyls KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicinal+Chemistry&rft.atitle=Curcumin+is+an+Inhibitor+of+p300+Histone+Acetylatransferase&rft.au=Marcu%2C+Monica+G%3BJung%2C+Yun-Jin%3BLee%2C+Sunmin%3BChung%2C+Eun-Joo%3BLee%2C+Min-Jung%3BTrepel%2C+Jane%3BNeckers%2C+Len&rft.aulast=Marcu&rft.aufirst=Monica&rft.date=2006-03-01&rft.volume=2&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Medicinal+Chemistry&rft.issn=15734064&rft_id=info:doi/10.2174%2F157340606776056133 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Histone deacetylase; Curcumin; Data processing; Histone acetyltransferase; natural products; Drug development; Peripheral blood; Lymphocytes; Prostate cancer; CBP protein; Histone H3; carbonyls DO - http://dx.doi.org/10.2174/157340606776056133 ER - TY - JOUR T1 - Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth AN - 20227434; 7332323 AB - Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels greater than or equal to 1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% "viable" (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects. JF - Environmental Pollution AU - De Nicola, Elena AU - Meric, Suereyya AU - Gallo, Marialuisa AU - Iaccarino, Mario AU - Della Rocca, Claudio AU - Lofrano, Giusy AU - Russo, Teresa AU - Pagano, Giovanni AD - Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I- 80131 Naples, Italy, gbpagano@tin.it Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 46 EP - 54 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 146 IS - 1 SN - 0269-7491, 0269-7491 KW - Heart urchins KW - Sand dollars KW - Sea urchins KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Vegetable tannin KW - Synthetic tannin KW - Leather tanning KW - Toxicity KW - Hormesis KW - Algae KW - Echinoderms KW - Vegetables KW - Cell culture KW - Sperm KW - Toxicity tests KW - Bioassay KW - Defects KW - Mimosa KW - Fertilization KW - Pollution indicators KW - Algal culture KW - Larvae KW - Embryonic development KW - Tannins KW - Sphaerechinus granularis KW - Embryogenesis KW - fertilization KW - Bioassays KW - hormesis KW - Water Pollution Effects KW - Progeny KW - Echinoidea KW - Abnormalities KW - Algal Growth KW - Growth KW - Dunaliella tertiolecta KW - Tannic acid KW - Pollution KW - Aquaculture techniques KW - offspring KW - Paracentrotus lividus KW - Marine KW - tannic acid KW - mimosa KW - Bioaccumulation KW - Cultures KW - Marine aquaculture KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24370:Natural Toxins KW - Q5 08504:Effects on organisms KW - AQ 00008:Effects of Pollution KW - SW 3030:Effects of pollution KW - K 03320:Cell Biology KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution&rft.atitle=Vegetable+and+synthetic+tannins+induce+hormesis%2Ftoxicity+in+sea+urchin+early+development+and+in+algal+growth&rft.au=De+Nicola%2C+Elena%3BMeric%2C+Suereyya%3BGallo%2C+Marialuisa%3BIaccarino%2C+Mario%3BDella+Rocca%2C+Claudio%3BLofrano%2C+Giusy%3BRusso%2C+Teresa%3BPagano%2C+Giovanni&rft.aulast=De+Nicola&rft.aufirst=Elena&rft.date=2006-03-01&rft.volume=146&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution&rft.issn=02697491&rft_id=info:doi/10.1016%2Fj.envpol.2006.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Algal culture; Growth; Bioassays; Bioaccumulation; Embryonic development; Marine aquaculture; Toxicity; Pollution indicators; Toxicity tests; Abnormalities; Aquaculture techniques; Defects; Embryogenesis; Fertilization; Vegetables; hormesis; Cell culture; Progeny; Sperm; Tannic acid; Pollution; Algae; fertilization; tannic acid; Larvae; offspring; Echinoderms; Water Pollution Effects; Cultures; Tannins; Algal Growth; Bioassay; Paracentrotus lividus; Mimosa; Dunaliella tertiolecta; mimosa; Echinoidea; Sphaerechinus granularis; Marine DO - http://dx.doi.org/10.1016/j.envpol.2006.06.018 ER - TY - JOUR T1 - Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen AN - 20221802; 6719606 AB - We have analyzed the level of gene coregulation, using gene expression patterns measured across the National Cancer Institute's 60 tumor cell panels (NCI sub(6) sub(0)), in the context of predefined pathways or functional categories annotated by KEGG (Kyoto Encyclopedia of Genes and Genomes), BioCarta, and GO (Gene Ontology). Statistical methods were used to evaluate the level of gene expression coherence (coordinated expression) by comparing intra- and interpathway gene-gene correlations. Our results show that gene expression in pathways, or groups of functionally related genes, has a significantly higher level of coherence than that of a randomly selected set of genes. Transcriptional-level gene regulation appears to be on a ''need to be'' basis, such that pathways comprising genes encoding closely interacting proteins and pathways responsible for vital cellular processes or processes that are related to growth or proliferation, specifically in cancer cells, such as those engaged in genetic information processing, cell cycle, energy metabolism, and nucleotide metabolism, tend to be more modular (lower degree of gene sharing) and to have genes significantly more coherently expressed than most signaling and regular metabolic pathways. Hierarchical clustering of pathways based on their differential gene expression in the NCI sub(6) sub(0) further revealed interesting interpathway communications or interactions indicative of a higher level of pathway regulation. The knowledge of the nature of gene expression regulation and biological pathways can be applied to understanding the mechanism by which small drug molecules interfere with biological systems. JF - Genomics AU - Huang, R AU - Wallqvist, A AU - Covell, D G AD - Developmental Therapeutics Program, Screening Technologies Branch, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA, covell@ncifcrf.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 315 EP - 328 PB - Elsevier Inc. VL - 87 IS - 3 SN - 0888-7543, 0888-7543 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Statistics KW - Energy metabolism KW - Cell cycle KW - Communication KW - Transcription KW - double prime GO gene KW - Tumor cells KW - Nucleotides KW - Cancer KW - Gene expression KW - Information processing KW - Gene regulation KW - Metabolic pathways KW - Cell proliferation KW - Drugs KW - Signal transduction KW - W 30940:Products KW - G 07470:Cytogenetics & general UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20221802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Comprehensive+analysis+of+pathway+or+functionally+related+gene+expression+in+the+National+Cancer+Institute%27s+anticancer+screen&rft.au=Huang%2C+R%3BWallqvist%2C+A%3BCovell%2C+D+G&rft.aulast=Huang&rft.aufirst=R&rft.date=2006-03-01&rft.volume=87&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2005.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Statistics; Energy metabolism; Cell cycle; Communication; Transcription; double prime GO gene; Tumor cells; Cancer; Nucleotides; Gene expression; Gene regulation; Information processing; Metabolic pathways; Cell proliferation; Drugs; Signal transduction DO - http://dx.doi.org/10.1016/j.ygeno.2005.11.011 ER - TY - JOUR T1 - Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay AN - 20220726; 6685596 AB - Monolayers of Hep G2/C3A cells were inoculated with genotype 1 Hepatitis E virus (HEV) mixed with either anti-HEV or an appropriate control. After 5 or 6 days, cell monolayers were stained with anti-HEV and infected cells were identified by immunofluorescence microscopy and counted. Anti-HEV from vaccinated or infected rhesus monkeys neutralized the virus, as did mAbs that recognized epitopes on the C terminus of a recombinant vaccine protein. Antibodies were broadly cross-reactive, since convalescent serum from animals infected with any one of the four mammalian genotypes all neutralized the genotype 1 virus. JF - Journal of General Virology AU - Emerson, Suzanne U AU - Clemente-Casares, Pilar AU - Moiduddin, Nasser AU - Arankalle, Vidya A AU - Torian, Udana AU - Purcell, Robert H AD - Molecular Hepatitis and Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC-8009, Bethesda, MD 20892-8009, USA, semerson@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 697 EP - 704 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 87 IS - 3 SN - 0022-1317, 0022-1317 KW - Rhesus monkey KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Monoclonal antibodies KW - Hepatitis E virus KW - Cell culture KW - Genotypes KW - Immunofluorescence KW - Vaccination KW - Antibodies KW - Microscopy KW - Macaca mulatta KW - Vaccines KW - Neutralization KW - Epitopes KW - W 30915:Pharmaceuticals & Vaccines KW - V 22092:Viral antigenic properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20220726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Virology&rft.atitle=Putative+neutralization+epitopes+and+broad+cross-genotype+neutralization+of+Hepatitis+E+virus+confirmed+by+a+quantitative+cell-culture+assay&rft.au=Emerson%2C+Suzanne+U%3BClemente-Casares%2C+Pilar%3BMoiduddin%2C+Nasser%3BArankalle%2C+Vidya+A%3BTorian%2C+Udana%3BPurcell%2C+Robert+H&rft.aulast=Emerson&rft.aufirst=Suzanne&rft.date=2006-03-01&rft.volume=87&rft.issue=3&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Virology&rft.issn=00221317&rft_id=info:doi/10.1099%2Fvir.0.81545-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; Monoclonal antibodies; Microscopy; Cell culture; Immunofluorescence; Vaccines; Genotypes; Vaccination; Neutralization; Epitopes; Macaca mulatta; Hepatitis E virus DO - http://dx.doi.org/10.1099/vir.0.81545-0 ER - TY - JOUR T1 - Characterization of a New NIH-Registered Variant Human Embryonic Stem Cell Line, BG01V: A Tool for Human Embryonic Stem Cell Research AN - 20204731; 6752836 AB - Human embryonic stem cells (hESCs) offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent manipulations. For example, identifying genes expressed during culture, as well as their temporal expression order after passaging and conditions influencing the formation of all three germ layers may be helpful for the production of functional beta islet cells used in treating type I diabetes. Although several hESC lines have demonstrated karyotypic instability during extended time in culture, select variant lines exhibit characteristics similar to their normal parental lines. Such variant lines may be excellent tools and abundant sources of cells for pilot studies and in vitro differentiation research in which chromosome number is not a concern, similar to the role currently played by embryonal carcinoma cell lines. It is crucial that the cells be surveyed at a genetic and proteomic level during extensive propagation, expansion, and manipulation in vitro. Here we describe a comprehensive characterization of the variant hESC line BG01V, which was derived from the karyotypically normal, parental hESC line BG01. Our characterization process employs cytogenetic analysis, short tandem repeat and HLA typing, mitochondrial DNA sequencing, gene expression analysis using quantitative reverse transcription-polymerase chain reaction and microarray, assessment of telomerase activity, methylation analysis, and immunophenotyping and teratoma formation, in addition to screening for bacterial, fungal, mycoplasma, and human pathogen contamination. JF - Stem Cells AU - Plaia, Todd W AU - Josephson, Richard AU - Liu, Ying AU - Zeng, Xianmin AU - Ording, Carol AU - Toumadje, Arazdordi AU - Brimble, Sandii N AU - Sherrer, Eric S AU - Uhl, Elizabeth W AU - Freed, William J AU - Schulz, Thomas C AU - Maitra, Anirban AU - Rao, Mahendra S AU - Auerbach, Jonathan M AD - Stem Cell Center, American Type Culture Collection, Manassas, Virginia, USA. Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Cellular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. BresaGen, Inc., Athens, Georgia, USA. Department of Veterinary Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, USA. Department of Pathology, Oncology, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 531 EP - 546 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - Short tandem repeats KW - Contamination KW - Telomerase KW - Tissue typing KW - Chromosome number KW - Islet cells KW - Cell culture KW - Pathogens KW - DNA microarrays KW - Diabetes mellitus KW - Differentiation KW - Tumor cell lines KW - Mitochondrial DNA KW - Stem cells KW - Embryo cells KW - teratoma KW - DNA methylation KW - proteomics KW - Mycoplasma KW - J 02310:Genetics & Taxonomy KW - W 30905:Medical Applications KW - G 07770:Bacteria KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20204731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Characterization+of+a+New+NIH-Registered+Variant+Human+Embryonic+Stem+Cell+Line%2C+BG01V%3A+A+Tool+for+Human+Embryonic+Stem+Cell+Research&rft.au=Plaia%2C+Todd+W%3BJosephson%2C+Richard%3BLiu%2C+Ying%3BZeng%2C+Xianmin%3BOrding%2C+Carol%3BToumadje%2C+Arazdordi%3BBrimble%2C+Sandii+N%3BSherrer%2C+Eric+S%3BUhl%2C+Elizabeth+W%3BFreed%2C+William+J%3BSchulz%2C+Thomas+C%3BMaitra%2C+Anirban%3BRao%2C+Mahendra+S%3BAuerbach%2C+Jonathan+M&rft.aulast=Plaia&rft.aufirst=Todd&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Short tandem repeats; Contamination; Telomerase; Tissue typing; Chromosome number; Cell culture; Islet cells; Pathogens; DNA microarrays; Diabetes mellitus; Differentiation; Stem cells; Mitochondrial DNA; Tumor cell lines; teratoma; Embryo cells; DNA methylation; proteomics; Mycoplasma ER - TY - JOUR T1 - [beta]-Adrenergic Receptor Polymorphisms and Response to Salmeterol AN - 199623443; 16322642 AB - Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists. We investigated whether such genotype-specific effects occur when patients are treated with long-acting beta-agonists and whether such effects are modified by concurrent inhaled corticosteroid (ICS) use. We compared salmeterol response in patients with asthma homozygous for arginine at B16 (B16Arg/Arg) with those homozygous for glycine at B16 (B16Gly/Gly) in two separate cohorts. In the first, subjects were randomized to regular therapy with salmeterol while simultaneously discontinuing ICS therapy. In the second, subjects were randomized to regular therapy with salmeterol while continuing concomitant ICS. In both trials, B16Arg/Arg subjects did not benefit compared with B16Gly/Gly subjects after salmeterol was initiated. In the first cohort, compared with placebo, the addition of salmeterol was associated with a 51.4 L/min lower A.M. peak expiratory flow (PEF; p = 0.005) in B16Arg/Arg subjects(salmeterol, n = 12; placebo, n = 5) as compared with B16Gly/Gly subjects (salmeterol, n = 13; placebo, n = 13). In the second cohort, B16Arg/Arg subjects treated with salmeterol and ICS concurrently (n = 8) had a lower A.M. PEF (36.8 L/min difference, p = 0.048) than B16Gly/Gly subjects (n = 22) treated with the same regimen. In addition, B16 Arg/Arg subjects in the second cohort had lower FEV1 (0.42 L, p = 0.003), increased symptom scores (0.2 units, p = 0.034), and increased albuterol rescue use (0.95 puffs/d, p = 0.004) compared with B16Gly/Gly subjects. Relative to B16Gly/Gly patients with asthma, B16Arg/Arg patients with asthma may have an impaired therapeutic response to salmeterol in either the absence or presence of concurrent ICS use. Investigation of alternate treatment strategies may benefit this group. JF - American Journal of Respiratory and Critical Care Medicine AU - Wechsler, Michael E AU - Lehman, Erik AU - Lazarus, Stephen C AU - Lemanske, Robert F, Jr AU - et al Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 519 EP - 26 CY - New York PB - American Thoracic Society VL - 173 IS - 5 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Adrenergic beta-Agonists KW - Glucocorticoids KW - Receptors, Adrenergic, beta KW - Triamcinolone KW - salmeterol KW - Albuterol KW - Genotype KW - Drug Therapy, Combination KW - Albuterol -- therapeutic use KW - Triamcinolone -- administration & dosage KW - Humans KW - Glucocorticoids -- administration & dosage KW - Adult KW - Administration, Inhalation KW - Male KW - Female KW - Asthma -- drug therapy KW - Receptors, Adrenergic, beta -- genetics KW - Albuterol -- analogs & derivatives KW - Polymorphism, Genetic KW - Asthma -- genetics KW - Adrenergic beta-Agonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199623443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=%5Bbeta%5D-Adrenergic+Receptor+Polymorphisms+and+Response+to+Salmeterol&rft.au=Wechsler%2C+Michael+E%3BLehman%2C+Erik%3BLazarus%2C+Stephen+C%3BLemanske%2C+Robert+F%2C+Jr%3Bet+al&rft.aulast=Wechsler&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=173&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Mar 1, 2006 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans AN - 19954424; 6787158 AB - The observation that Toll-like receptor (TLR)2-deficient mice are highly susceptible to mycobacteria suggests that mutations altering TLR2 expression may impair host response to Mycobacterium tuberculosis. We evaluated the association between guanine-thymine (GT) repeat polymorphism in intron II of the TLR2 gene and the presence of tuberculosis (TB) in Koreans. The numbers of GT repeats were determined by PCR and gene scans for 176 TB patients and 196 controls. The recombinant TLR2 promoter/exonl/exonll/intronll/luciferase constructs including three representative repeats: (GT) sub(13), (GT) sub(20), and (GT) sub(24) were transfected into K562 cells, and iuciferase activities were estimated and compared. The expression of TLR2 on CD14 + peripheral blood mononuclear cells (PBMC) from healthy volunteers were measured with flow cytometry. Genotypes with shorter GT repeats were more common among TB patients (49.4 vs37.7%, P=0.02). This observation was confirmed among 82 other TB patients as a validation cohort. Shorter GT repeats were associated with weaker promoter activities and lower TLR2 expression on CD14+ PBMCs. In conclusion, the development of TB disease in Koreans was associated with shorter GT repeats in intron II of the TLR2 gene. This association is correlated with lower expression of TLR2 through weaker promoter activity for genes with shorter GT repeats. JF - Genes and Immunity AU - Yim, J-J AU - Lee, H W AU - Lee, H S AU - Kim, Y W AU - Han, S K AU - Shim, Y-S AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, CRC B3-4141, 10 Center Drive, MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 150 EP - 155 VL - 7 IS - 2 SN - 1466-4879, 1466-4879 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Gene polymorphism KW - TLR2 protein KW - Microsatellites KW - CD14 antigen KW - Flow cytometry KW - Promoters KW - Peripheral blood mononuclear cells KW - Introns KW - Polymerase chain reaction KW - Tuberculosis KW - Korea, Rep. KW - Mutation KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - G 07240:Immunogenetics KW - J 02350:Immunology KW - F 06414:Other genes (e.g. cytokine genes) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19954424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+and+Immunity&rft.atitle=The+association+between+microsatellite+polymorphisms+in+intron+II+of+the+human+Toll-like+receptor+2+gene+and+tuberculosis+among+Koreans&rft.au=Yim%2C+J-J%3BLee%2C+H+W%3BLee%2C+H+S%3BKim%2C+Y+W%3BHan%2C+S+K%3BShim%2C+Y-S%3BHolland%2C+S+M&rft.aulast=Yim&rft.aufirst=J-J&rft.date=2006-03-01&rft.volume=7&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Genes+and+Immunity&rft.issn=14664879&rft_id=info:doi/10.1038%2Fsj.gene.6364274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Promoters; Peripheral blood mononuclear cells; Gene polymorphism; TLR2 protein; Microsatellites; Introns; Polymerase chain reaction; Tuberculosis; CD14 antigen; Mutation; Toll-like receptors; Mycobacterium tuberculosis; Korea, Rep. DO - http://dx.doi.org/10.1038/sj.gene.6364274 ER - TY - JOUR T1 - Synthesis of hypermodified adenosine derivatives as selective adenosine A sub(3) receptor ligands AN - 19950299; 6659438 AB - We investigated the A sub(3)AR affinity and selectivity of a series of 2- substituted 3'-azido and 3'-amino adenosine derivatives as well as some 5'- uronamide derivatives thereof. All compounds showed high A sub(3)AR selectivity. While the 3'-azides appeared to be A sub(3)AR antagonists with moderate A sub(3)AR affinity, their 3'-amino congeners exhibit significantly improved A sub(3)AR affinity and behave as partial agonists. For both the 3'-azides and the 3'- amines, the 5'-methylcarbamoyl modification improved the overall affinity. Introduction of a 2-phenylethynyl substituent provided high affinity for the A sub(3)AR. JF - Bioorganic and Medicinal Chemistry AU - Cosyn, Liesbet AU - Gao, Zhan-Guo AU - Van Rompaey, Philippe AU - Lu, Changrui AU - Jacobson, Kenneth A AU - Van Calenbergh, Serge AD - Laboratory for Medicinal Chemistry (FFW), UGent, Harelbekestraat 72, B-9000, Belgium, kajacobs@helix.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1403 EP - 1412 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 5 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Adenosine A sub(3) receptor KW - Selectivity KW - Affinity KW - Ribose and purine modifications KW - amines KW - Adenosine A3 receptors KW - Congeners KW - Adenosine KW - Antagonists KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19950299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+of+hypermodified+adenosine+derivatives+as+selective+adenosine+A+sub%283%29+receptor+ligands&rft.au=Cosyn%2C+Liesbet%3BGao%2C+Zhan-Guo%3BVan+Rompaey%2C+Philippe%3BLu%2C+Changrui%3BJacobson%2C+Kenneth+A%3BVan+Calenbergh%2C+Serge&rft.aulast=Cosyn&rft.aufirst=Liesbet&rft.date=2006-03-01&rft.volume=14&rft.issue=5&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2005.09.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Adenosine A3 receptors; amines; Congeners; Adenosine; Antagonists DO - http://dx.doi.org/10.1016/j.bmc.2005.09.062 ER - TY - JOUR T1 - The Newborn Drug Development Initiative AN - 19901528; 6715433 AB - The Best Pharmaceuticals for Children Act (BPCA; Pub L 107-109) was enacted in January 2002 and will sunset in October 2007. The BPCA established processes for studying off-patent and on-patent drugs that are used in pediatric population. Although some drugs have been successfully developed for the neonate (eg, surfactant, nitric oxide), drug development for the youngest, least mature, and most vulnerable pediatric patients is generally lacking. Most drugs are empirically administered to newborns once efficacy has been demonstrated in adults and usefulness is suspected or demonstrated in the older pediatric population. Unfortunately, this process undermines the ability to perform the appropriate studies necessary to demonstrate a drug's short- and long-term safety and efficacy and establish appropriate dosing in neonates. The Newborn Drug Development Initiative Workshop I (held March 29-30, 2004) specifically addressed scientific, clinical, and ethical concerns in the development of trials of pediatric therapeutic agents for neonates. Implementation of the BPCA for all pediatric populations will foster collaboration among federal agencies and academic institutions on scientific investigation, clinical-study design, and consideration of the weight of evidence and address ethical issues related to the performance of drug studies. JF - Pediatrics AU - Giacoia, George P AU - Birenbaum, Debra L AU - Sachs, Hari Cheryl AU - Mattison, Donald R AD - Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Division of Pediatric Drug Development, Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - S1 EP - S8 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 3 SN - 0031-4005, 0031-4005 KW - Biotechnology and Bioengineering Abstracts KW - Conferences KW - Pediatrics KW - Ethics KW - Pharmaceuticals KW - Drug development KW - Nitric oxide KW - Neonates KW - Children KW - Drugs KW - Clinical trials KW - Surfactants KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19901528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=The+Newborn+Drug+Development+Initiative&rft.au=Giacoia%2C+George+P%3BBirenbaum%2C+Debra+L%3BSachs%2C+Hari+Cheryl%3BMattison%2C+Donald+R&rft.aulast=Giacoia&rft.aufirst=George&rft.date=2006-03-01&rft.volume=117&rft.issue=3&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Conferences; Pediatrics; Ethics; Pharmaceuticals; Nitric oxide; Drug development; Neonates; Children; Surfactants; Clinical trials; Drugs ER - TY - JOUR T1 - Natural Products from Marine Invertebrates and Microbes as Modulators of Antitumor Targets AN - 19895300; 7643279 AB - Over the last twenty-five to thirty years, exploration of the marine fauna and microbial flora has progressed from a random search by natural product chemists who liked to dive and wished to combine their hobby with their profession, to fully integrated programs of systemic investigation of the chemical agents elaborated by marine organisms of all phyla (as presumably defensive agents against predators) for their potential as leads to human-use drug candidates where the putative mechanisms have been identified as modulation of, and/or interaction with, potential molecular targets, rather than just exhibiting general cytotoxicity. This review is not exhaustive but is meant to cover the highlights of such agents and is arranged on a (nominal) target basis rather than by organism or chemical class. JF - Current Drug Targets AU - Newman, D J AU - Cragg, G M AD - Natural Products Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD, 21702, USA. Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 279 EP - 304 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 3 SN - 1389-4501, 1389-4501 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts KW - Marine natural products KW - molecular targets KW - cancer KW - structural modification KW - Cytotoxicity KW - Marine fauna KW - Reviews KW - Invertebrata KW - Marine organisms KW - natural products KW - Predators KW - Drug development KW - Antitumor agents KW - Q4 27740:Products KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=The+psychology+of+the+crowd&rft.au=Katz%2C+Daniel&rft.aulast=Katz&rft.aufirst=Daniel&rft.date=1950-01-01&rft.volume=&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=Fields+of+psychology%3A+Basic+and+applied+%282nd+ed.%2C+3rd+printing%29&rft.title=Fields+of+psychology%3A+Basic+and+applied+%282nd+ed.%2C+3rd+printing%29&rft.issn=&rft_id=info:doi/10.1037%2F11550-007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Marine fauna; Reviews; Marine organisms; Drug development; Predators; natural products; Antitumor agents; Invertebrata DO - http://dx.doi.org/10.2174/138945006776054960 ER - TY - JOUR T1 - Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task AN - 19843654; 6854294 AB - The neuropeptide galanin impairs learning and memory in rodents. The mechanism underlying the cognitive effects of galanin may be related to inhibitory effects of galanin on cholinergic transmission. As cholinergic function is thought to modulate sustained attention, the present study examined whether galanin-overexpressing transgenic mice have impairments in sustained attention. Galanin transgenic (GAL-tg) mice and wild-type (WT) littermate controls were trained in a 5-choice serial reaction time task, modified to assess sustained attention. GAL-tg and WT mice performed similarly during acquisition with respect to accuracy, total omissions, and response speed. Attentional mechanisms were challenged by parametric changes including increased event rate, event asynchrony, or decreased stimulus duration. Singly, these challenges did not differentially affect performance between genotypes. Concurrent administration of these challenges, which represents an optimal test of sustained attention, also had similar effects on GAL-tg and WT mice. When stimulus discriminability was reduced by constant illumination of the house light, GAL-tg mice omitted more trials than WT mice, but other measures of performance did not differ by genotype. Moreover, intraventricular injection of galanin in WT mice did not affect sustained attention. These data indicate that previously reported learning and memory effects of galanin are not secondary to attentional dysfunction. JF - Pharmacology Biochemistry and Behavior AU - Wrenn, Craige C AU - Turchi, Janita N AU - Schlosser, Sophie AU - Dreiling, Jennifer L AU - Stephenson, Dejaimenay A AU - Crawley, Jacqueline N AD - Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA, craige.wrenn@drake.edu Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 428 EP - 440 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 83 IS - 3 SN - 0091-3057, 0091-3057 KW - Transgenic mice KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Galanin KW - Attention KW - Mice KW - Five-choice KW - Operant KW - Transgenic KW - Neuropeptide KW - Acetylcholine KW - Learning KW - Data processing KW - Genotypes KW - Light effects KW - Memory KW - Serial learning KW - Illumination KW - Cholinergic transmission KW - Cognitive ability KW - Reaction time task KW - Neuropeptides KW - W 30925:Genetic Engineering KW - N3 11046:Memory and learning KW - Y 25517:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Performance+of+galanin+transgenic+mice+in+the+5-choice+serial+reaction+time+attentional+task&rft.au=Wrenn%2C+Craige+C%3BTurchi%2C+Janita+N%3BSchlosser%2C+Sophie%3BDreiling%2C+Jennifer+L%3BStephenson%2C+Dejaimenay+A%3BCrawley%2C+Jacqueline+N&rft.aulast=Wrenn&rft.aufirst=Craige&rft.date=2006-03-01&rft.volume=83&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2006.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Learning; Data processing; Genotypes; Transgenic mice; Light effects; Galanin; Serial learning; Memory; Cholinergic transmission; Illumination; Reaction time task; Cognitive ability; Attention; Neuropeptides DO - http://dx.doi.org/10.1016/j.pbb.2006.03.003 ER - TY - JOUR T1 - Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani AN - 19841166; 6765881 AB - Fusarium spp. have emerged as important causes of invasive fungal infections in immunocompromised patients. Rabbit pulmonary alveolar macrophages (PAMs) exhibited fungicidal activity against conidia of Fusarium solani and achieved a time-dependent increase in killing. Neither deoxycholate amphotericin B (DAMB) nor amphotericin B lipid complex (ABLC) exerted a suppressive effect on PAMs by decreasing their conidiocidal activity against F. solani. On the contrary, at a concentration of 0.125 mu g ml super(-1), ABLC and, to a lesser degree, DAMB additively augmented the fungicidal activity of pulmonary alveolar macrophages against conidia of Fusarium solani. JF - Mycoses AU - Roilides, Emmanuel AU - Lyman, Caron A AU - Armstrong, Derek AU - Stergiopoulou, Theodouli AU - Petraitiene, Ruta AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MA, USA, walsht@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 109 EP - 113 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 49 IS - 2 SN - 0933-7407, 0933-7407 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Fusarium solani KW - pulmonary alveolar macrophages KW - amphotericin B formulations KW - Macrophages KW - Amphotericin B KW - Lung KW - Lipids KW - Immunocompromised hosts KW - Fungicidal activity KW - Antifungal activity KW - Conidia KW - Infection KW - Alveoli KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19841166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mycoses&rft.atitle=Deoxycholate+amphotericin+B+and+amphotericin+B+lipid+complex+exert+additive+antifungal+activity+in+combination+with+pulmonary+alveolar+macrophages+against+Fusarium+solani&rft.au=Roilides%2C+Emmanuel%3BLyman%2C+Caron+A%3BArmstrong%2C+Derek%3BStergiopoulou%2C+Theodouli%3BPetraitiene%2C+Ruta%3BWalsh%2C+Thomas+J&rft.aulast=Roilides&rft.aufirst=Emmanuel&rft.date=2006-03-01&rft.volume=49&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Mycoses&rft.issn=09337407&rft_id=info:doi/10.1111%2Fj.1439-0507.2006.01202.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 1; tables, 1. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Amphotericin B; Lung; Immunocompromised hosts; Lipids; Antifungal activity; Fungicidal activity; Conidia; Infection; Alveoli; Fusarium solani DO - http://dx.doi.org/10.1111/j.1439-0507.2006.01202.x ER - TY - JOUR T1 - AAV transcytosis through barrier epithelia and endothelium AN - 19836948; 6818145 AB - To transduce efficiently barrier epithelia such as the lung is the goal of several gene therapy applications. However, experiments with AAV-2 suggest that transduction is limited in this type of barrier epithelia. In contrast, other serotypes of AAV transduce barrier epithelia and exhibit broad dissemination throughout the tissue. Transcytosis is a process by which proteins and pathogens overcome barrier layers to reach the opposite cell surface. To understand better the entry pathway of AAV particles and their ability to penetrate barrier epithelia, we tested the hypothesis that the limited transduction of some barrier epithelia in vitro or the spread of some AAV serotypes through tissue in vivo is due to transcytosis. Our experiments demonstrate that dependoviruses can penetrate barrier cells by transcytosis. The process is rapid as well as serotype and cell-type specific and can be blocked by neutralizing antibodies, temperature, or chemical inhibitors of transcytosis. The particles isolated following apical-to-basolateral transport are still encapsulated and they can transduce permissive cell lines in vitro. Furthermore, the entry pathway used by AAV-5 for transcytosis appears to be independent of the one used for transduction. Importantly, inhibition of virus transcytosis results in a dramatic increase in intracellular vector and transduction. JF - Molecular Therapy AU - Di Pasquale, Giovanni AU - Chiorini, John A AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 506 EP - 516 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 3 SN - 1525-0016, 1525-0016 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - adeno-associated virus KW - transcytosis KW - virus entry KW - virus trafficking KW - Temperature effects KW - Expression vectors KW - Cell surface KW - Antibodies KW - Serotypes KW - Gene therapy KW - Permissive cells KW - Lung KW - Endothelium KW - Pathogens KW - Adeno-associated virus KW - W3 33181:Gene therapy vectors KW - V 22410:Animal Diseases KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19836948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=AAV+transcytosis+through+barrier+epithelia+and+endothelium&rft.au=Di+Pasquale%2C+Giovanni%3BChiorini%2C+John+A&rft.aulast=Di+Pasquale&rft.aufirst=Giovanni&rft.date=2006-03-01&rft.volume=13&rft.issue=3&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1016%2Fj.ymthe.2005.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Expression vectors; Temperature effects; Cell surface; Antibodies; Serotypes; Gene therapy; Lung; Permissive cells; Endothelium; Pathogens; Adeno-associated virus DO - http://dx.doi.org/10.1016/j.ymthe.2005.11.007 ER - TY - JOUR T1 - High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes AN - 19772084; 6749405 AB - With current concerns of antibiotic-resistant bacteria and biodefense, it has become important to rapidly identify infectious bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are time-consuming. We report a rapid and simple method that combines in vivo biotinylation of engineered host-specific bacteriophage and conjugation of the phage to streptavidin-coated quantum dots. The method provides specific detection of as few as 10 bacterial cells per milliliter in experimental samples, with an approximately 100-fold amplification of the signal over background in 1 h. We believe that the method can be applied to any bacteria susceptible to specific phages and would be particularly useful for detection of bacterial strains that are slow growing, e.g., Mycobacterium, or are highly infectious, e.g., Bacillus anthracis. The potential for simultaneous detection of different bacterial species in a single sample and applications in the study of phage biology are discussed. JF - Proceedings of the National Academy of Sciences, USA AU - Edgar, Rotem AU - McKinstry, Michael AU - Hwang, Jeeseong AU - Oppenheim, Amos B AU - Fekete, Richard A AU - Giulian, Gary AU - Merril, Carl AU - Nagashima, Kunio AU - Adhya, Sankar AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 4841 EP - 4845 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 13 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Conjugation KW - Mycobacterium KW - Quantum dots KW - Bacillus anthracis KW - Biotinylation KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=High-sensitivity+bacterial+detection+using+biotin-tagged+phage+and+quantum-dot+nanocomplexes&rft.au=Edgar%2C+Rotem%3BMcKinstry%2C+Michael%3BHwang%2C+Jeeseong%3BOppenheim%2C+Amos+B%3BFekete%2C+Richard+A%3BGiulian%2C+Gary%3BMerril%2C+Carl%3BNagashima%2C+Kunio%3BAdhya%2C+Sankar&rft.aulast=Edgar&rft.aufirst=Rotem&rft.date=2006-03-01&rft.volume=103&rft.issue=13&rft.spage=4841&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Conjugation; Quantum dots; Biotinylation; Mycobacterium; Bacillus anthracis ER - TY - JOUR T1 - Enhanced soluble protein expression using two new fusion tags AN - 19770442; 6726517 AB - Production of soluble recombinant proteins is vital for structure-function analysis and therapeutic applications. Unfortunately, when expressed in a heterologous host, such as Escherichia coli, most proteins are expressed as insoluble aggregates. Two new fusion partners have been identified to address these solubility problems. One of the tags was derived from a bacteriophage T7 protein kinase and the other one from a small E. coli chaperone, Skp. We have expressed a panel of insoluble human proteins including Hifl alpha , IL13, and folliculin as fusion proteins using these tags. Most of these fusion proteins were able to be expressed in a soluble form and could be purified by virtue of a Strep-tag II installed at the amino-terminal end of the fusion partners. In addition, we show that some of these proteins remained soluble after removal of the fusion tags by a site-specific protease. The results with these tags compare favorably to results with the most commonly used solubility tags described in the literature. Therefore, these two new fusion tags have the potential to express soluble proteins when fused with many recalcitrant proteins. JF - Protein Expression and Purification AU - Chatterjee, D K AU - Esposito, D AD - Protein Expression Laboratory, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Building 327 Frederick, MD 21702, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 122 EP - 129 VL - 46 IS - 1 SN - 1046-5928, 1046-5928 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Phages KW - Interleukin 13 KW - Solubility KW - T7 protein KW - Escherichia coli KW - Therapeutic applications KW - Proteinase KW - Chaperones KW - Fusion protein KW - protein purification KW - W 30925:Genetic Engineering KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Enhanced+soluble+protein+expression+using+two+new+fusion+tags&rft.au=Chatterjee%2C+D+K%3BEsposito%2C+D&rft.aulast=Chatterjee&rft.aufirst=D&rft.date=2006-03-01&rft.volume=46&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2005.07.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Interleukin 13; Solubility; T7 protein; Therapeutic applications; Chaperones; Proteinase; protein purification; Fusion protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.pep.2005.07.028 ER - TY - JOUR T1 - Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals AN - 19715644; 7494338 AB - Studies [Zhou, D., Chen, L.-M., Hernandez, L., Shears, S.B., and Galan, J.E. (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host-cell actin cytoskeleton rearrangements and bacterial internalization. Mol. Microbiol. 39, 248-259] with engineered Salmonella mutants showed that deletion of SopE attenuated the pathogen's ability to deplete host-cell InsP5 and remodel the cytoskeleton. We pursued these observations: In SopE-transfected host-cells, membrane ruffling was induced, but SopE did not dephosphorylate InsP5, nor did it recruit PTEN (a cytosolic InsP5 phosphatase) for this task. However, PTEN strengthened SopE-mediated membrane ruffling. We conclude SopE promotes host-cell InsP5 hydrolysis only with the assistance of other Salmonella proteins. Our demonstration that Salmonella-mediated cytoskeletal modifications are independent of inositolphosphates will focus future studies on elucidating alternate pathogenic consequences of InsP5 metabolism, including ion channel conductance and apoptosis. JF - FEBS Letters AU - Deleu, Sandrine AU - Choi, Kuicheon AU - Reece, Jeff M AU - Shears, Stephen B AD - Inositol Signaling Section, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA, shears@niehs.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1709 EP - 1715 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 580 IS - 7 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology KW - SopE KW - InsP5 KW - Inositolphosphate KW - Cytoskeleton KW - Membrane ruffling KW - Salmonella KW - Apoptosis KW - Conductance KW - Inositol KW - PTEN protein KW - Hydrolysis KW - inositol phosphate KW - Pathogenicity KW - Ion channels KW - Actin KW - Metabolism KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19715644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Pathogenicity+of+Salmonella%3A+SopE-mediated+membrane+ruffling+is+independent+of+inositol+phosphate+signals&rft.au=Deleu%2C+Sandrine%3BChoi%2C+Kuicheon%3BReece%2C+Jeff+M%3BShears%2C+Stephen+B&rft.aulast=Deleu&rft.aufirst=Sandrine&rft.date=2006-03-01&rft.volume=580&rft.issue=7&rft.spage=1709&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2006.02.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Apoptosis; Pathogenicity; inositol phosphate; Conductance; Membrane ruffling; Inositol; Ion channels; Actin; PTEN protein; Hydrolysis; Metabolism; Salmonella DO - http://dx.doi.org/10.1016/j.febslet.2006.02.019 ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19690714; 7456858 AB - To compare global and regional myocardial infarction (MI) measurements on clinical gadolinium-enhanced magnetic resonance (MR) images using human manual contouring and a computer algorithm previously validated by histopathology, and to study the degree to which visual assessment and human contouring of infarct extent agreed with the computer algorithm. Infarct size in 20 patients was measured by human manual contouring and with an automated feature analysis and combined thresholding (FACT) computer algorithm. Short-axis slices were divided into myocardial sectors for regional analysis. Extent of infarction was also graded visually by consensus of expert readers and compared to human and computer contouring. Despite good correlations (R = 0.93-0.95) between human contouring and the FACT algorithm, human contouring overestimated infarct size by 3.8% of the left ventricle (23.8% of the MI) area (P < 0.001). Human contouring also overestimated the circumferential extent, transmural extent, and extent of infarction within a sector by 7.1%, 18.2%, and 27.9%, respectively (all P < 0.001). Both consensus reading and human contouring overestimated infarct grades compared with the FACT algorithm (P = 0.002 and P < 0.001). Clinically relevant overestimation of MI can occur in visual interpretation and in human manual contouring, particularly with respect to extent of infarction on a regional basis. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Ingkanisorn, WPatricia AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 309 EP - 314 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - myocardial viability KW - magnetic resonance imaging KW - computer aided diagnosis KW - contrast agent KW - gadolinium KW - Ventricle KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+II%3A+Clinical+application+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BIngkanisorn%2C+WPatricia%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20495 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ventricle; Computers; Magnetic resonance imaging; Algorithms; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20495 ER - TY - JOUR T1 - Quantitative myocardial perfusion analysis with a dual-bolus contrast- enhanced first-pass MRI technique in humans AN - 19690396; 7456868 AB - To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual-bolus first-pass perfusion MRI method in humans. Rest and dipyridamole stress perfusion imaging was performed on 10 healthy humans by administering gadolinium contrast using a dual-bolus protocol. Ventricular and myocardial time-signal intensity curves were generated from a series of T1-weighted images and adjusted for surface-coil intensity variations. Corrected signal intensity curves were then fitted using fully quantitative model constrained deconvolution (MCD) to quantify MBF (mL/min/g) and MPR. The results were compared with semiquantitative contrast enhancement ratio (CER) and upslope index (SLP) measurements. MBF (mL/min/g) estimated with MCD averaged 1.02 +/- 0.22 at rest and 3.39 +/- 0.59 for stress with no overlap in measures. MPR was 3.43 +/- 0.71, 1.91 +/- 0.65, and 1.16 +/- 0.19 using MCD, SLP, and CER. Both semiquantitative parameters (SLP and CER) significantly underestimated MPR (P < 0.001) and failed to completely discriminate rest and stress perfusion. Rest and stress MBF (mL/min/g) and MPR estimated by dual-bolus perfusion MRI fit within published ranges. Semiquantitative methods (SLP and CER) significantly underestimated MPR. J. Magn. Reson. Imaging 2006. Published by Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Rhoads, Kenneth L AU - Holly, Jessica E AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 315 EP - 322 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - magnetic resonance imaging KW - myocardial perfusion KW - myocardial blood flow KW - myocardial perfusion reserve KW - contrast agent KW - gadolinium KW - Perfusion KW - Magnetic resonance imaging KW - Gadolinium KW - Stress KW - Dipyridamole KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+perfusion+analysis+with+a+dual-bolus+contrast-+enhanced+first-pass+MRI+technique+in+humans&rft.au=Hsu%2C+Li-Yueh%3BRhoads%2C+Kenneth+L%3BHolly%2C+Jessica+E%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Perfusion; Gadolinium; Magnetic resonance imaging; Stress; Dipyridamole; Models DO - http://dx.doi.org/10.1002/jmri.20502 ER - TY - JOUR T1 - Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents AN - 19681921; 8169528 AB - Aberrant signaling through protein-tyrosine kinase (PTK)-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth factor receptor bound protein 2 (Grb2) is an important downstream mediator of PTK signaling that serves obligatory roles in many pathogenic processes. One of the primary functions of Grb2 is to bind to specific phosphotyrosyl (pTyr)-containing sequences through its Src homology 2 (SH2) domain. Agents that bind to the Grb2 SH2 domain and prevent its normal function could disrupt associated PTK signaling and serve as alternatives to kinase-directed inhibitors. Starting from the X-ray crystal structure of a lead peptide bound to the Grb2 SH2 domain, this review will summarize important contributions to these efforts. The presentation will be thematically arranged according to the region of peptide modified, proceeding from the N-terminus to the C-terminus, with a special section devoted to aspects of conformational constraint. JF - International Journal of Peptide Research and Therapeutics AU - Burke, Terrence R AD - NCI-Frederick, Bldg. 376 Boyles St., P.O. Box B, Frederick, MD, 21702-1201, USA, tburke@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 33 EP - 48 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 12 IS - 1 SN - 1573-3149, 1573-3149 KW - Biotechnology and Bioengineering Abstracts KW - Grb2 protein KW - C-Terminus KW - Cancer KW - Antagonists KW - N-Terminus KW - Homology KW - Growth factor receptors KW - Reviews KW - Ionizing radiation KW - Protein-tyrosine kinase KW - Src protein KW - Crystal structure KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Peptide+Research+and+Therapeutics&rft.atitle=Development+of+Grb2+SH2+Domain+Signaling+Antagonists%3A+A+Potential+New+Class+of+Antiproliferative+Agents&rft.au=Burke%2C+Terrence+R&rft.aulast=Burke&rft.aufirst=Terrence&rft.date=2006-03-01&rft.volume=XI&rft.issue=2-3&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Journal+of+British+Cinema+and+Television&rft.issn=17434521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Grb2 protein; C-Terminus; Antagonists; Cancer; N-Terminus; Homology; Ionizing radiation; Reviews; Growth factor receptors; Protein-tyrosine kinase; Crystal structure; Src protein; Signal transduction DO - http://dx.doi.org/10.1007/s10989-006-9014-7 ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19681796; 7456859 AB - To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference. Delayed enhancement MR was performed in 11 dogs with myocardial infarction (MI) determined by triphenyltetrazolium chloride (TTC). Infarct size on in vivo and ex vivo images was measured by a computer algorithm based on automated feature analysis and combined thresholding (FACT). For comparison, infarct size by human manual contouring and simple intensity thresholding (based on two standard deviation [2SD] and full width at half maximum [FWHM]) were studied. Both in vivo and ex vivo MR infarct size measured by the FACT algorithm correlated well with TTC (R = 0.95-0.97) and showed no significant bias on Bland Altman analysis (P = not significant). Despite similar correlations (R = 0.91-0.97), human manual contouring overestimated in vivo MR infarct size by 5.4% of the left ventricular (LV) area (equivalent to 55.1% of the MI area) vs. TTC (P < 0.001). Infarct size measured by simple intensity thresholdings was less accurate than the proposed algorithm (P < 0.001 and P = 0.007). The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Natanzon, Alex AU - Kellman, Peter AU - Hirsch, Glenn A AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 298 EP - 308 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - magnetic resonance imaging KW - computer algorithm KW - image processing KW - expert system KW - contrast agent KW - gadolinium KW - Standard deviation KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Triphenyltetrazolium chloride KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+I%3A+Animal+validation+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BNatanzon%2C+Alex%3BKellman%2C+Peter%3BHirsch%2C+Glenn+A%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standard deviation; Computers; Magnetic resonance imaging; Algorithms; Triphenyltetrazolium chloride; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20496 ER - TY - JOUR T1 - Bombesin/Gastrin-Releasing Peptide Receptor Antagonists Increase the Ability of Histone Deacetylase Inhibitors to Reduce Lung Cancer Proliferation AN - 19648772; 7393109 AB - The effects of a bombesin/gastrin releasing peptide (BB/GRP) receptor antagonist, PD176252, and histone deacetylase (HDAC) Inhibitor, MS-275, were investigated on human lung cancer cell lines. Using the MTT assay, PD176252 and MS-275 inhibited the proliferation of NCI-H1299 cells with IC sub(50) values of 7 and 5 mu g/mL, respectively. Using MS-275 and PD176252 together, the ability to inhibit lung cancer cellular growth increased significantly. The combination index for MS-275 and PD176252 was <0.2, indicating that the compounds are highly synergistic in inhibiting lung cancer cellular growth. Also, MS-275 and PD176252 together strongly inhibited the cional growth of NCI-H345 or NCI-H1299 cells. MS-275 had little effect on the expression of lung cancer cellular GRP or GRP receptors, but increased expression of transforming growth factor- beta receptor II (TGF- beta RII). These results indicate that GRP receptor antagonists may potentiate the action of histone deacetylase inhibitors on lung cancer cellular proliferation by increasing expression of tumor suppressor genes. JF - Journal of Molecular Neuroscience AU - Moody, T W AU - Nakagawa, T AU - Kang, Y AU - Jakowlew, S AU - Chan, D AU - Jensen, R T AD - Department of Health and Human Services, Office of the Director, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 231 EP - 238 VL - 28 IS - 3 SN - 0895-8696, 0895-8696 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gastrin-releasing peptide KW - Histone deacetylase KW - Tumor suppressor genes KW - Tumor cell lines KW - Transforming growth factor- beta KW - Bombesin KW - Gastrin KW - transforming growth factor- beta receptors KW - Cell proliferation KW - Antagonists KW - Lung cancer KW - N3 11007:Neurobiology KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19648772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Neuroscience&rft.atitle=Bombesin%2FGastrin-Releasing+Peptide+Receptor+Antagonists+Increase+the+Ability+of+Histone+Deacetylase+Inhibitors+to+Reduce+Lung+Cancer+Proliferation&rft.au=Moody%2C+T+W%3BNakagawa%2C+T%3BKang%2C+Y%3BJakowlew%2C+S%3BChan%2C+D%3BJensen%2C+R+T&rft.aulast=Moody&rft.aufirst=T&rft.date=2006-03-01&rft.volume=28&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Neuroscience&rft.issn=08958696&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gastrin-releasing peptide; Tumor suppressor genes; Histone deacetylase; Tumor cell lines; Transforming growth factor- beta; Gastrin; Bombesin; transforming growth factor- beta receptors; Cell proliferation; Antagonists; Lung cancer ER - TY - JOUR T1 - Effects of early and later family violence on children's behavior problems and depression: A longitudinal, multi-informant perspective AN - 19455695; 7639264 AB - Objectives To examine the effects of different forms of family violence at two developmental stages by assessing a sample of 110 Israeli children, drawn from the case files of Israeli family service agencies, studied longitudinally in both middle childhood and adolescence. Methods Information about the children's adjustment was obtained from parents, teachers, and the children themselves when the children averaged 10.6 and 15.9 years of age using the Child Behavior Checklist (CBCL), Teacher Report Form (TRF), Youth Self-Report (YSR), and Children's Depression Inventory (CDI). Information about the history of family violence was obtained from the mothers, fathers, children, and social workers. Results The results paint a mixed picture of the effects of family violence on children and adolescents. The relationship between concurrent behavior problems and abuse group varied by informant and study phase, although they were strongest when children were the informants. Predictions regarding the relationship between early abuse and later adjustment were only partially confirmed. Different informants did not agree about which groups of children were most adversely affected, there was little stability over time in the pattern of reported effects, and children were more likely than other informants to report levels of maladjustment that varied depending on recent or concurrent exposure to family violence. Many families changed their abuse status over time, and children who were new victims at follow-up had the most internalizing problems. Girls were found to be at more risk for internalizing and externalizing behavior problems than boys. Conclusions Multiple informants are necessary to evaluate and assess the effects of family violence on children's behavior. Younger children may be more susceptible to the effects of family violence than older children, but problems manifest by some children may not carry over to adolescence. Changes in family and parenting practices, as well as in children's capacity to appraise and cope with family violence may help mitigate the adverse effects of family violence. JF - Child Abuse & Neglect AU - Sternberg, Kathleen J AU - Lamb, Michael E AU - Guterman, Eva AU - Abbott, Craig B AD - National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, United States Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 283 EP - 306 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 3 SN - 0145-2134, 0145-2134 KW - Risk Abstracts KW - Family violence KW - Child abuse KW - Internalizing behavior problems KW - Externalizing behavior problems KW - Maladjustment KW - Historical account KW - Behavior KW - developmental stages KW - Children KW - Violence KW - depression KW - Side effects KW - Adolescents KW - Paints KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19455695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+%26+Neglect&rft.atitle=Effects+of+early+and+later+family+violence+on+children%27s+behavior+problems+and+depression%3A+A+longitudinal%2C+multi-informant+perspective&rft.au=Sternberg%2C+Kathleen+J%3BLamb%2C+Michael+E%3BGuterman%2C+Eva%3BAbbott%2C+Craig+B&rft.aulast=Sternberg&rft.aufirst=Kathleen&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+%26+Neglect&rft.issn=01452134&rft_id=info:doi/10.1016%2Fj.chiabu.2005.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Historical account; Behavior; developmental stages; Children; depression; Violence; Adolescents; Side effects; Paints DO - http://dx.doi.org/10.1016/j.chiabu.2005.10.008 ER - TY - JOUR T1 - Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease AN - 19447141; 6752862 AB - The umbilical cord contains an inexhaustible, noncontroversial source of stem cells for therapy. In the U.S., stem cells found in the umbilical cord are routinely placed into bio-hazardous waste after birth. Here, stem cells derived from human umbilical cord Wharton's Jelly, called umbilical cord matrix stem (UCMS) cells, are characterized. UCMS cells have several properties that make them of interest as a source of cells for therapeutic use. For example, they 1) can be isolated in large numbers, 2) are negative for CD34 and CD45, 3) grow robustly and can be frozen/thawed, 4) can be clonally expanded, and 5) can easily be engineered to express exogenous proteins. UCMS cells have genetic and surface markers of mesenchymal stem cells (positive for CD10, CD13, CD29, CD44, and CD90 and negative for CD14, CD33, CD56, CD31, CD34, CD45, and HLA-DR) and appear to be stable in terms of their surface marker expression in early passage (passages 4-8). Unlike traditional mesenchymal stem cells derived from adult bone marrow stromal cells, small populations of UCMS cells express endoglin (SH2, CD105) and CD49e at passage 8. UCMS cells express growth factors and angiogenic factors, suggesting that they may be used to treat neurodegenerative disease. To test the therapeutic value of UCMS cells, undifferentiated human UCMS cells were transplanted into the brains of hemiparkinsonian rats that were not immune-suppressed. UCMS cells ameliorated apomorphine-induced rotations in the pilot test. UCMS cells transplanted into normal rats did not produce brain tumors, rotational behavior, or a frank host immune rejection response. In summary, the umbilical cord matrix appears to be a rich, noncontroversial, and inexhaustible source of primitive mesenchymal stem cells. JF - Stem Cells AU - Weiss, Mark L AU - Medicetty, Satish AU - Bledsoe, Amber R AU - Rachakatla, Raja Shekar AU - Choi, Michael AU - Merchav, Shosh AU - Luo, Yongquan AU - Rao, Mahendra S AU - Velagaleti, Gopalrao AU - Troyer, Deryl AD - Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, USA. ViaCell Singapore Research Centre, Singapore. Laboratory of Neuroscience, National Institute on Aging, Bethesda, Maryland, USA. Children's Hospital, Galveston, Texas, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 781 EP - 792 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Histocompatibility antigen HLA KW - CD13 antigen KW - stromal cells KW - Parkinson's disease KW - Umbilical cord KW - Stem cells KW - CD105 antigen KW - CD45 antigen KW - Wastes KW - CD34 antigen KW - Movement disorders KW - CD90 antigen KW - Endoglin KW - CD44 antigen KW - Animal models KW - Bone marrow KW - Angiogenesis KW - CD14 antigen KW - Rotational behavior KW - Growth factors KW - Mesenchyme KW - Transplantation KW - CD56 antigen KW - Brain tumors KW - Neurodegenerative diseases KW - Surface markers KW - W 30905:Medical Applications KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19447141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Human+Umbilical+Cord+Matrix+Stem+Cells%3A+Preliminary+Characterization+and+Effect+of+Transplantation+in+a+Rodent+Model+of+Parkinson%27s+Disease&rft.au=Weiss%2C+Mark+L%3BMedicetty%2C+Satish%3BBledsoe%2C+Amber+R%3BRachakatla%2C+Raja+Shekar%3BChoi%2C+Michael%3BMerchav%2C+Shosh%3BLuo%2C+Yongquan%3BRao%2C+Mahendra+S%3BVelagaleti%2C+Gopalrao%3BTroyer%2C+Deryl&rft.aulast=Weiss&rft.aufirst=Mark&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stem cells; Umbilical cord; Mesenchyme; Neurodegenerative diseases; CD45 antigen; CD34 antigen; Surface markers; Angiogenesis; CD13 antigen; CD56 antigen; CD105 antigen; Bone marrow; Movement disorders; CD90 antigen; Histocompatibility antigen HLA; Endoglin; CD14 antigen; Wastes; Rotational behavior; Animal models; stromal cells; Transplantation; CD44 antigen; Brain tumors; Parkinson's disease; Growth factors ER - TY - JOUR T1 - Graph Theoretical Insights into Evolution of Multidomain Proteins AN - 19440070; 6833527 AB - We study properties of multidomain proteins from a graph theoretical perspective. In particular, we demonstrate connections between properties of the domain overlap graph and certain variants of Dollo parsimony models. We apply our graph theoretical results to address several interrelated questions: do proteins acquire new domains infrequently, or often enough that the same combinations of domains will be created repeatedly through independent events? Once domain architectures are created do they persist? In other words, is the existence of ancestral proteins with domain compositions not observed in contemporary proteins unlikely? Our experimental results indicate that independent merges of domain pairs are not uncommon in large superfamilies. JF - Journal of Computational Biology AU - Przytycka, T AU - Davis, G AU - Song, N AU - Durand, D AD - National Center for Biotechnology Information, US Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, przytyck@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 351 EP - 363 VL - 13 IS - 2 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Computer applications KW - Evolution KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Graph+Theoretical+Insights+into+Evolution+of+Multidomain+Proteins&rft.au=Przytycka%2C+T%3BDavis%2C+G%3BSong%2C+N%3BDurand%2C+D&rft.aulast=Przytycka&rft.aufirst=T&rft.date=2006-03-01&rft.volume=13&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Evolution; Models; Computer applications ER - TY - JOUR T1 - Assessing Self-Renewal and Differentiation in Human Embryonic Stem Cell Lines AN - 19438241; 6752835 AB - Like other cell populations, undifferentiated human embryonic stem cells (hESCs) express a characteristic set of proteins and mRNA that is unique to the cells regardless of culture conditions, number of passages, and methods of propagation. We sought to identify a small set of markers that would serve as a reliable indicator of the balance of undifferentiated and differentiated cells in hESC populations. Markers of undifferentiated cells should be rapidly downregulated as the cells differentiate to form embryoid bodies (EBs), whereas markers that are absent or low during the undifferentiated state but that are induced as hESCs differentiate could be used to assess the presence of differentiated cells in the cultures. In this paper, we describe a list of markers that reliably distinguish undifferentiated and differentiated cells. An initial list of approximately 150 genes was generated by scanning published massively parallel signature sequencing, expressed sequence tag scan, and microarray datasets. From this list, a subset of 109 genes was selected that included 55 candidate markers of undifferentiated cells, 46 markers of hESC derivatives, four germ cell markers, and four trophoblast markers. Expression of these candidate marker genes was analyzed in undifferentiated hESCs and differentiating EB populations in four different lines by immunocytochemistry, reverse transcription-polymer-ase chain reaction (RT-PCR), microarray analysis, and quantitative RT-PCR (qPCR). We show that qPCR, with as few as 12 selected genes, can reliably distinguish differentiated cells from undifferentiated hESC populations. JF - Stem Cells AU - Cai, Jingli AU - Chen, Jia AU - Liu, Ying AU - Miura, Takumi AU - Luo, Yongquan AU - Loring, Jeanne F AU - Freed, William J AU - Rao, Mahendra S AU - Zeng, Xianmin AD - Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services (DHHS), Baltimore, Maryland, USA. Cellular Neurobiology Branch, National Institute on Drug Abuse, DHHS, Baltimore, Maryland, USA. Program in Stem Cells and Regeneration, The Burnham Institute, La Jolla, California, USA. Invitrogen, Carlsbad, California, USA. Buck Insititute, Novato, California, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 516 EP - 530 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunocytochemistry KW - Differentiation KW - Stem cells KW - Embryo cells KW - Scanning KW - Germ cells KW - Polymerase chain reaction KW - Trophoblasts KW - Cell culture KW - DNA microarrays KW - expressed sequence tags KW - W 30905:Medical Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessing+Self-Renewal+and+Differentiation+in+Human+Embryonic+Stem+Cell+Lines&rft.au=Cai%2C+Jingli%3BChen%2C+Jia%3BLiu%2C+Ying%3BMiura%2C+Takumi%3BLuo%2C+Yongquan%3BLoring%2C+Jeanne+F%3BFreed%2C+William+J%3BRao%2C+Mahendra+S%3BZeng%2C+Xianmin&rft.aulast=Cai&rft.aufirst=Jingli&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Immunocytochemistry; Stem cells; Scanning; Embryo cells; Germ cells; Trophoblasts; Polymerase chain reaction; Cell culture; expressed sequence tags; DNA microarrays ER - TY - JOUR T1 - IMMUNOHEMATOLOGY: The gene overexpressed in polycythemia rubra vera, PRV-1, and the gene encoding a neutrophil alloantigen, NB1, are alleles of a single gene, CD177, in chromosome band 19q13.31 AN - 19438183; 6767049 AB - BACKGROUND: PRV-1 mRNA is overexpressed by neutrophils from polycythemia vera patients and is homologous to NB1 a gene overexpressed in reactive neutrophilia. STUDY DESIGN AND METHODS: These investigations were designed to confirm searches of genome databases suggesting that PRV-1 and NB1 are alleles of the same gene, CD177, and confirm a pseudogene adjacent to CD177. Methods included polymerase chain reaction (PCR), cloning, sequencing, and fluorescent hybridization studies. RESULTS: The coding region of PRV-1 was PCR-amplified from human fetal RNA, cloned, and used to screen the RPCI-11 bacterial artificial chromosome (BAC) library. Five BACs were reactive with the PRV-1 probe. PCR analysis of the BACs with primers encompassing PRV-1 exons, containing four known single-nucleotide polymorphisms, followed by sequencing rendered amplicons identical to PRV-1 in all five BACs. Analysis of all five by restriction digestion yielded fragments possible only if both the gene and the pseudogene are present. End sequencing of the BACs localized them to the same chromosome region. G-banding and fluorescence in situ hybridization at the 400- and 850-band levels of resolution mapped one BAC to chromosome band 19q13.2 and sublocalized the BAC to band 19q13.31, respectively. CONCLUSION: PRV-1 and NB1 are alleles of the same gene now referred to as CD177. Changes in CD177 expression may be a marker of increased or decreased myelopoiesis and are therefore an effect of, rather than a cause of, myeloproliferative disorders. JF - Transfusion AU - Caruccio, Lorraine AU - Bettinotti, Maria AU - Myska, Alison E AU - Arthur, Diane C AU - Stroncek, David AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, lcaruccio@mail.cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 441 EP - 447 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 46 IS - 3 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Polycythemia KW - Genomes KW - Pseudogenes KW - Myelopoiesis KW - Exons KW - DNA probes KW - Leukocytes (neutrophilic) KW - Polycythemia vera KW - Fetuses KW - mRNA KW - Bacterial artificial chromosomes KW - Databases KW - Chromosomes KW - Single-nucleotide polymorphism KW - Alloantigens KW - Polymerase chain reaction KW - Myeloproliferative diseases KW - Primers KW - Neutrophilia KW - Fluorescence in situ hybridization KW - G 07880:Human Genetics KW - J 02400:Human Diseases KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=IMMUNOHEMATOLOGY%3A+The+gene+overexpressed+in+polycythemia+rubra+vera%2C+PRV-1%2C+and+the+gene+encoding+a+neutrophil+alloantigen%2C+NB1%2C+are+alleles+of+a+single+gene%2C+CD177%2C+in+chromosome+band+19q13.31&rft.au=Caruccio%2C+Lorraine%3BBettinotti%2C+Maria%3BMyska%2C+Alison+E%3BArthur%2C+Diane+C%3BStroncek%2C+David&rft.aulast=Caruccio&rft.aufirst=Lorraine&rft.date=2006-03-01&rft.volume=46&rft.issue=3&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2006.00741.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - SuppNotes - Figures, 3; tables, 2; references, 11. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Polycythemia; Pseudogenes; Myelopoiesis; Exons; DNA probes; Leukocytes (neutrophilic); Polycythemia vera; Fetuses; mRNA; Bacterial artificial chromosomes; Databases; Chromosomes; Single-nucleotide polymorphism; Alloantigens; Polymerase chain reaction; Primers; Myeloproliferative diseases; Neutrophilia; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1111/j.1537-2995.2006.00741.x ER - TY - JOUR T1 - Magnetic Resonance Imaging and Confocal Microscopy Studies of Magnetically Labeled Endothelial Progenitor Cells Trafficking to Sites of Tumor Angiogenesis AN - 19432401; 6752850 AB - AC133 cells, a subpopulation of CD34 super(+) hematopoietic stem cells, can transform into endothelial cells that may integrate into the neovasculature of tumors or ischemic tissue. Most current imaging modalities do not allow monitoring of early migration and incorporation of endothelial progenitor cells (EPCs) into tumor neovasculature. The goals of this study were to use magnetic resonance imaging (MRI) to track the migration and incorporation of intravenously injected, magnetically labeled EPCs into the blood vessels in a rapidly growing flank tumor model and to determine whether the pattern of EPC incorporation is related to the time of injection or tumor size. Materials and Methods: EPCs labeled with ferumoxide-protamine sulfate (FePro) complexes were injected into mice bearing xenografted glioma, and MRI was obtained at different stages of tumor development and size. Results: Migration and incorporation of labeled EPCs into tumor neovasculature were detected as low signal intensity on MRI at the tumor periphery as early as 3 days after EPC administration in preformed tumors. However, low signal intensities were not observed in tumors implanted at the time of EPC administration until tumor size reached 1 cm at 12 to 14 days. Prussian blue staining showed iron-positive cells at the sites corresponding to low signal intensity on MRI. Confocal microcopy showed incorporation into the neovasculature, and immunohistochemistry clearly demonstrated the transformation of the administered EPCs into endothelial cells. Conclusion: MRI demonstrated the incorporation of FePro-labeled human CD34 super(+)/AC133 super(+) EPCs into the neovasculature of implanted flank tumors. JF - Stem Cells AU - Arbab, Ali S AU - Frenkel, Victor AU - Pandit, Sunil D AU - Anderson, Stasia A AU - Yocum, Gene T AU - Bur, Monica AU - Khuu, Hanh M AU - Read, Elizabeth J AU - Frank, Joseph A AD - Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Molecular Imaging Laboratory, Clinical Center, National Institute of Neurological Disorders and Stroke, Clinical Center, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA. Radiology, Henry Ford Health System, Detroit, Michigan, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 671 EP - 678 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Magnetic resonance imaging KW - Animal models KW - Angiogenesis KW - Developmental stages KW - CD34 antigen KW - Ischemia KW - Tumors KW - Sulfate KW - Brain tumors KW - Endothelial cells KW - Stem cells KW - Blood vessels KW - Confocal microscopy KW - Glioma KW - Cell migration KW - Immunohistochemistry KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19432401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Magnetic+Resonance+Imaging+and+Confocal+Microscopy+Studies+of+Magnetically+Labeled+Endothelial+Progenitor+Cells+Trafficking+to+Sites+of+Tumor+Angiogenesis&rft.au=Arbab%2C+Ali+S%3BFrenkel%2C+Victor%3BPandit%2C+Sunil+D%3BAnderson%2C+Stasia+A%3BYocum%2C+Gene+T%3BBur%2C+Monica%3BKhuu%2C+Hanh+M%3BRead%2C+Elizabeth+J%3BFrank%2C+Joseph+A&rft.aulast=Arbab&rft.aufirst=Ali&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Magnetic resonance imaging; Stem cells; Cell migration; Endothelial cells; CD34 antigen; Angiogenesis; Developmental stages; Confocal microscopy; Ischemia; Blood vessels; Animal models; Glioma; Brain tumors; Immunohistochemistry; Sulfate; Transformation ER - TY - JOUR T1 - Targeting multidrug resistance in cancer AN - 19429522; 6702422 AB - Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In most cases, multiple drugs are used, as resistance to single agents occurs almost universally. For this reason, elucidation of mechanisms that confer simultaneous resistance to different drugs with different targets and chemical structures-multidrug resistance-has been a major goal of cancer biologists during the past 35 years. Here, we review the most common of these mechanisms, one that relies on drug efflux from cancer cells mediated by ATP- binding cassette (ABC) transporters. We describe various approaches to combating multidrug-resistant cancer, including the development of drugs that engage, evade or exploit efflux by ABC transporters. JF - Nature Reviews: Drug Discovery AU - Szakacs, Gergely AU - Paterson, Jill K AU - Ludwig, Joseph A AU - Booth-Genthe, Catherine AU - Gottesman, Michael M AD - Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest Karolina ut 29; H-1518, Hungary., MGottesman@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 219 EP - 234 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 5 IS - 3 SN - 1474-1776, 1474-1776 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - ABC transporter KW - Drug resistance KW - Chemotherapy KW - Reviews KW - Drug development KW - Multidrug resistance KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19429522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Targeting+multidrug+resistance+in+cancer&rft.au=Szakacs%2C+Gergely%3BPaterson%2C+Jill+K%3BLudwig%2C+Joseph+A%3BBooth-Genthe%2C+Catherine%3BGottesman%2C+Michael+M&rft.aulast=Szakacs&rft.aufirst=Gergely&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd1984 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Reviews; ABC transporter; Chemotherapy; Drug resistance; Multidrug resistance; Drug development; Metastases DO - http://dx.doi.org/10.1038/nrd1984 ER - TY - JOUR T1 - Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt AN - 19428793; 6753773 AB - The serine/threonine kinase Akt is a promising target in cancer. We previously identified five phosphatidylinositol ether lipid analogues (PIA) that inhibited Akt activation and selectively killed lung and breast cancer cells with high levels of Akt activity. To assess the spectrum of activity in other cell types and to compare PIAs with other inhibitors of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, we compared growth inhibition by PIAs against the PI3K inhibitors LY294002 and wortmannin and the mTOR inhibitor rapamycin in the NCI60 cell line panel. Although each of these compounds inhibited the growth of all the cell lines, distinct patterns were observed. The PIAs were the least potent but the most cytotoxic. The broad spectrum of activity of PIAs was confirmed in vivo in hollow fiber assays. The response to PIAs was significantly correlated with levels of active but not total Akt in the NCI60, as assessed using COMPARE analysis. However, a number of molecular targets were identified whose expression was more highly correlated with sensitivity to PIAs than active Akt. Expression of these molecular targets did not overlap with those that correlated with sensitivity to LY294002, wortmannin, or rapamycin. A COMPARE analysis of the National Cancer Institute chemical screening database revealed that the patterns of activity of PIAs correlated best with patterns of activity of other lipid-based compounds. These studies show that although PIAs are widely active in cancer cells, which correlates with the presence of its intended target, active Akt, PIAs are biologically distinct from other known inhibitors of the PI3K/Akt/mTOR pathway. [Mol Cancer Ther 2006; 5(3):713-22] JF - Molecular Cancer Therapeutics AU - Gills, Joell J AU - Holbeck, Susan AU - Hollingshead, Melinda AU - Hewitt, Stephen M AU - Kozikowski, Alan P AU - Dennis, Phillip A AD - Medical Oncology Branch and Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 713 EP - 722 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 5 IS - 3 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Protein-serine/threonine kinase KW - phosphatidylinositol KW - Lipids KW - Fibers KW - Databases KW - Cytotoxicity KW - 1-Phosphatidylinositol 3-kinase KW - AKT protein KW - Breast cancer KW - Ethers KW - TOR protein KW - Rapamycin KW - Lung cancer KW - Wortmannin KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Spectrum+of+activity+and+molecular+correlates+of+response+to+phosphatidylinositol+ether+lipid+analogues%2C+novel+lipid-based+inhibitors+of+Akt&rft.au=Gills%2C+Joell+J%3BHolbeck%2C+Susan%3BHollingshead%2C+Melinda%3BHewitt%2C+Stephen+M%3BKozikowski%2C+Alan+P%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - AKT protein; 1-Phosphatidylinositol 3-kinase; Lipids; Ethers; Wortmannin; phosphatidylinositol; Rapamycin; Lung cancer; Breast cancer; Databases; Protein-serine/threonine kinase; TOR protein; Cytotoxicity; Fibers ER - TY - JOUR T1 - Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization AN - 19427387; 6703424 AB - Understanding the cell biology of many proteins requires knowledge of their in vivo topological distribution. Here we describe a new fluorescence-based technique, fluorescence protease protection (FPP), for investigating the topology of proteins and for localizing protein subpopulations within the complex environment of the living cell. In the FPP assay, adapted from biochemical protease protection assays, GFP fusion proteins are used as noninvasive tools to obtain details of protein topology and localization within living cells in a rapid and straightforward manner. To demonstrate the broad applicability of FPP, we used the technique to define the topology of proteins localized to a wide range of organelles including the endoplasmic reticulum (ER), Golgi apparatus, mitochondria, peroxisomes and autophagosomes. The success of the FPP assay in characterizing the topology of the tested proteins within their appropriate compartments suggests this technique has wide applicability in studying protein topology and localization within the cell. JF - Nature Methods AU - Lorenz, Holger AU - Hailey, Dale W AU - Lippincott-Schwartz, Jennifer AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 18T Library Drive, Bethesda, Maryland 20892, USA., jlippin@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 205 EP - 210 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 3 SN - 1548-7091, 1548-7091 KW - Biotechnology and Bioengineering Abstracts KW - Golgi apparatus KW - Chimeras KW - Endoplasmic reticulum KW - Fluorescence KW - Mitochondria KW - Proteinase KW - Fusion protein KW - Organelles KW - Peroxisomes KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19427387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=Fluorescence+protease+protection+of+GFP+chimeras+to+reveal+protein+topology+and+subcellular+localization&rft.au=Lorenz%2C+Holger%3BHailey%2C+Dale+W%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Lorenz&rft.aufirst=Holger&rft.date=2006-03-01&rft.volume=3&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth857 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Proteinase; Fluorescence; Endoplasmic reticulum; Organelles; Mitochondria; Fusion protein; Peroxisomes; Chimeras; Golgi apparatus DO - http://dx.doi.org/10.1038/nmeth857 ER - TY - JOUR T1 - How do we do it? Practical advice on imaging-based techniques and investigations AN - 19283253; 8633095 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Goncalves, L F AU - Lee, W AU - Espinoza, J AU - Romero, R AD - Perinatology Research Branch, National Institute of Child Health and Human Development, NIH/DHHS, Bethesda, MD, USA, warfiela@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 336 EP - 348 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 27 IS - 3 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19283253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Risk+of+Large-Scale+Evacuation+Based+on+the+Effectiveness+of+Rescue+Strategies+Under+Different+Crowd+Densities&rft.au=Wang%2C+Jinghong%3BLo%2C+Siuming%3BWang%2C+Qingsong%3BSun%2C+Jinhua%3BMu%2C+Honglin&rft.aulast=Wang&rft.aufirst=Jinghong&rft.date=2013-08-01&rft.volume=33&rft.issue=8&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2012.01923.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Gynecology; Ultrasound DO - http://dx.doi.org/10.1002/uog.2724 ER - TY - JOUR T1 - NMR and Crystallographic Characterization of Adventitious Borate Binding by Trypsin AN - 17699535; 7599126 AB - Recent super(11) B NMR studies of the formation of ternary complexes of trypsin, borate, and S1-binding alcohols revealed evidence for an additional binding interaction external to the enzyme active site. We have explored this binding interaction as a prototypical interaction of borate and boronate ligands with residues on the protein surface. NMR studies of trypsin in which the active site is blocked with leupeptin or with the irreversible inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) indicate the existence of a low-affinity borate binding site with an apparent dissociation constant of 97 mM, measured at pH 8.0. Observation of a field-dependent dynamic frequency shift of the super(11)B resonance indicates that it corresponds to a complex for which cot >> 1. The 0.12 ppm shift difference of the borate resonances measured at 11.75 and 7.05 T, corresponds to a quadrupole coupling constant of 260 kHz. A much larger 2.0 ppm shift is observed in the super(11)B NMR spectra of trypsin complexed with benzene boronic acid (BBA), leading to a calculated quadrupole coupling constant of 1.1 MHz for this complex. Crystallographic studies identify the second borate binding site as a serine-rich region on the surface of the molecule. Specifically, a complex obtained at pH 10.6 shows a borate ion covalently bonded to the hydroxyl oxygen atoms of Ser164 and Ser167, with additional stabilization coming from two hydrogen-bonding interactions. A similar structure, although with low occupancy (30%), is observed for a trypsin-BBA complex. In this case, the BBA is also observed in the active site, covalently bound in two different conformations to both His57 N epsilon and Ser195 O gamma . An analysis of pairwise hydroxyl oxygen distances was able to predict the secondary borate binding site in porcine trypsin, and this approach is potentially useful for prediction of borate binding sites on the surfaces of other proteins. However, the distances between the Ser164/Ser167 O gamma atoms in all of the reported trypsin crystal structures is significantly greater than the O gamma distances of 2.2 and 1.9 A observed in the trypsin complexes with borate and BBA, respectively. Thus, the ability of the hydroxyl oxygens to adopt a sufficiently close orientation to allow bidentate ligation is a critical limit on the borate binding affinity of surface-accessible serine/threonine/tyrosine residues. JF - Bioconjugate Chemistry AU - Transue, T R AU - Gabel, SA AU - London, R E AD - National Institute of Environmental Health Sciences, Laboratory of Structural Biology, Box 12233, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 300 EP - 308 VL - 17 IS - 2 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Leupeptin KW - Trypsin KW - Tyrosine KW - Enzymes KW - Benzene KW - Oxygen KW - Fluoride KW - alcohols KW - Crystal structure KW - N.M.R. KW - Threonine KW - pH effects KW - Serine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17699535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=NMR+and+Crystallographic+Characterization+of+Adventitious+Borate+Binding+by+Trypsin&rft.au=Transue%2C+T+R%3BGabel%2C+SA%3BLondon%2C+R+E&rft.aulast=Transue&rft.aufirst=T&rft.date=2006-03-01&rft.volume=17&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0502210 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Leupeptin; Trypsin; Enzymes; Tyrosine; Benzene; Oxygen; Fluoride; Crystal structure; alcohols; N.M.R.; pH effects; Threonine; Serine DO - http://dx.doi.org/10.1021/bc0502210 ER - TY - JOUR T1 - Pharmacogenetics of irinotecan metabolism and transport: An update AN - 17473213; 6654160 AB - The anticancer agent irinotecan (CPT-11) is converted to SN-38, which is approximately 100 to 1000-fold more cytotoxic than the parent drug. The pharmacokinetics of irinotecan are extremely complex and have been the subject of intensive investigation in recent years. Irinotecan is subject to extensive metabolism by various polymorphic enzymes, including CES2 to form SN-38, members of the UGT1A subfamily, and CYP3A4 and CYP3A5, which form several pharmacologically inactive oxidation products. Elimination of irinotecan is also dependent on drug-transporting proteins, notably ABCB1 (P-glycoprotein), ABCC2 (cMOAT) and ABCG2 (BCRP), present on the bile canalicular membrane. The various processes mediating drug elimination, either through metabolic breakdown or excretion, likely impact substantially on interindividual variability in drug handling. This report provides an update on current strategies to individualize irinotecan chemotherapy based on each patient's genetic constitution, which may ultimately lead to more selective use of this agent. JF - Toxicology In Vitro AU - Smith, Nicola F AU - Figg, William D AU - Sparreboom, Alex AD - Molecular Pharmacology Section, Medical Oncology Branch, National Cancer Institute, 9000 Rockville Pike, Building 10/Room 5A01, Bethesda, MD, USA, wdfigg@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 163 EP - 175 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 20 IS - 2 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - CPT-11 KW - SN-38 KW - CYP3A KW - CES KW - UGT1A KW - ABCB1 KW - ABCC1 KW - ABCC2 KW - ABCG2 KW - Chemotherapy KW - Irinotecan KW - Enzymes KW - Antitumor agents KW - Pharmacokinetics KW - Pharmacogenetics KW - Cytotoxicity KW - P-Glycoprotein KW - Bile KW - Oxidation KW - Excretion KW - Drugs KW - Metabolism KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17473213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Pharmacogenetics+of+irinotecan+metabolism+and+transport%3A+An+update&rft.au=Smith%2C+Nicola+F%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Smith&rft.aufirst=Nicola&rft.date=2006-03-01&rft.volume=20&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2005.06.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemotherapy; Irinotecan; Enzymes; Antitumor agents; Pharmacogenetics; Pharmacokinetics; P-Glycoprotein; Cytotoxicity; Bile; Oxidation; Excretion; Drugs; Metabolism DO - http://dx.doi.org/10.1016/j.tiv.2005.06.045 ER - TY - JOUR T1 - A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 Activity AN - 17260323; 6988132 AB - ABCG2 is a member of the adenosine triphosphate (ATP)-binding cassette family of multidrug transporters associated with resistance of tumor cells to many cytotoxic agents. Evaluation of modulators of ABCG2 activity has relied on methods such as drug sensitization, biochemical characterization, and transport studies. To search for novel inhibitors of ABCG2, a fluorescent cell-based assay was developed for application in high-throughput screening. Accumulation of pheophorbide a (PhA), an ABCG2-specific substrate, forms the basis for the assay in NCI-H460/MX20 cells overexpressing wild-type ABCG2. Treatment of these cells with 10 mu M fumitremorgin C (FTC), a specific ABCG2 inhibitor, increased cell accumulation of PhA to 5.6 times control (Z' 0.5). Validation included confirmation with known ABCG2 inhibitors: FTC, novobiocin, tariquidar, and quercetin. Verapamil, reported to inhibit P-glycoprotein but not ABCG2, had insignificant activity. Screening of a library of 3523 natural products identified 11 compounds with high activity (> 50% of FTC, confirmed by reassay), including 3 flavonoids, members of a family of compounds that include ABCG2 inhibitors. One of the inhibitors detected, eupatin, was moderately potent (IC sub(50) of 2.2 mu M) and, like FTC, restored sensitivity of resistant cells to mitoxantrone. Application of this assay to other libraries of synthetic compounds and natural products is expected to identify novel inhibitors of ABCG2 activity. JF - Journal of Biomolecular Screening AU - Henrich, C J AU - Bokesch, H R AU - Dean, M AU - Bates, SE AU - Robey, R W AU - Goncharova, E I AU - Wilson, JA AU - McMahon, J B AD - Basic Research Program, SAIC-Frederick, Inc., NCI Frederick, Frederick, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 176 EP - 183 VL - 11 IS - 2 SN - 1087-0571, 1087-0571 KW - ABCG2 protein KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - P-Glycoprotein KW - Flavonoids KW - Verapamil KW - Novobiocin KW - ATP KW - natural products KW - Cytotoxic agents KW - high-throughput screening KW - mitoxantrone KW - Tumor cells KW - Quercetin KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17260323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=A+High-Throughput+Cell-Based+Assay+for+Inhibitors+of+ABCG2+Activity&rft.au=Henrich%2C+C+J%3BBokesch%2C+H+R%3BDean%2C+M%3BBates%2C+SE%3BRobey%2C+R+W%3BGoncharova%2C+E+I%3BWilson%2C+JA%3BMcMahon%2C+J+B&rft.aulast=Henrich&rft.aufirst=C&rft.date=2006-03-01&rft.volume=11&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057105284576 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flavonoids; P-Glycoprotein; Verapamil; Novobiocin; ATP; high-throughput screening; Cytotoxic agents; natural products; Quercetin; Tumor cells; mitoxantrone DO - http://dx.doi.org/10.1177/1087057105284576 ER - TY - JOUR T1 - Parthenolide has limited effects on nuclear factor-[kappa] beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice AN - 17191630; 6865622 AB - Parthenolide, a sesquiterpene lactone, inhibited lipopolysaccharide (LPS) stimulated nuclear factor (NF)-[kappa] beta and cytokine production in vitro and in rats, and improved survival in LPS challenged Swiss albino mice. We investigated whether increased survival with parthenolide was associated directly with inhibition of NF-[kappa] beta and cytokines in LPS challenged C57BL/6J mice. In RAW 264.7 cells, parthenolide inhibited LPS-stimulated NF-[kappa] beta and cytokines (interleukin [IL]-1 alpha , -1 beta , -2, -4, -6, and -10, interferon- gamma , tumor necrosis factor- alpha , granulocyte macrophage-colony stimulating factor, migratory inhibitory protein-1 and -2 alpha , JE, and RANTES). In mice (n = 366) receiving lethal intraperitoneal (i.p.) LPS (40 mg/kg), compared to placebo, each of 5 parthenolide doses (0.25 to 4 mg/kg i.p. following LPS) reduced survival at 168 h and overall worsened the hazards ratio of survival (mean +/- S.E.M.) (1.29 +/- 0.12, p = 0.04). In other mice (241), compared to saline challenge, nonlethal LPS (2.5 mg/kg) increased NF-[kappa] beta in lung and kidney combined and 12 of 13 plasma cytokines early (1 and 3 h) and late (6, 9 and 12 h) (p <= 0.002 for each). Compared to nonlethal LPS, lethal LPS increased NF-[kappa] beta and 12 of 13 cytokines early but not significantly and late significantly (p <= 0.05 for each). With lethal LPS, compared to placebo, parthenolide (1 mg/kg) decreased NF-[kappa] beta and 10 of 13 cytokines early and increased NF-[kappa] beta and 11 of 13 cytokines late (p <= 0.02 for early vs. late). Although parthenolide inhibits NF-[kappa] beta and cytokines in vitro, its effects on these mediators and survival in animal sepsis models vary. Theses differences must be understood before parthenolide or related agents are applied clinically for sepsis. JF - Cytokine AU - Li, Xuemei AU - Cui, Xizhong AU - Li, Yan AU - Fitz, Yvonne AU - Hsu, Lewis AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA, peichacker@cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 299 EP - 308 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 33 IS - 6 SN - 1043-4666, 1043-4666 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anti-inflammatory agent KW - Lipopolysaccharide KW - Treatment KW - Signaling molecules KW - gamma -Interferon KW - Interleukins KW - Granulocyte-macrophage colony-stimulating factor KW - Animal models KW - Survival KW - RANTES KW - sesquiterpene lactones KW - NF- Kappa B protein KW - Sepsis KW - Lung KW - Kidney KW - Cytokines KW - Lipopolysaccharides KW - Tumor necrosis factor- alpha KW - Cell migration KW - J 02350:Immunology KW - F 06512:Immunopharmacology and general Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17191630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Parthenolide+has+limited+effects+on+nuclear+factor-%5Bkappa%5D+beta+increases+and+worsens+survival+in+lipopolysaccharide-challenged+C57BL%2F6J+mice&rft.au=Li%2C+Xuemei%3BCui%2C+Xizhong%3BLi%2C+Yan%3BFitz%2C+Yvonne%3BHsu%2C+Lewis%3BEichacker%2C+Peter+Q&rft.aulast=Li&rft.aufirst=Xuemei&rft.date=2006-03-01&rft.volume=33&rft.issue=6&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/10.1016%2Fj.cyto.2006.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Animal models; Granulocyte-macrophage colony-stimulating factor; Interleukins; RANTES; Survival; sesquiterpene lactones; NF- Kappa B protein; Sepsis; Lung; Kidney; Lipopolysaccharides; Cytokines; Cell migration; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.cyto.2006.03.002 ER - TY - JOUR T1 - Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism AN - 17172625; 6761917 AB - Coxiella burnetii directs the synthesis of a large parasitophorous vacuole (PV) required for replication. While some lysosomal characteristics of the PV have been described, the origin and composition of the PV membrane is largely undefined. Cholesterol is an essential component of mammalian cell membranes where it plays important regulatory and structural roles. Here we investigated the role of host cholesterol in biogenesis and maintenance of the C. burnetii PV in Vero cells. The C. burnetii PV membrane stained with filipin and was positive for the lipid raft protein flotillin-1, suggesting PV membranes are enriched in cholesterol and contain lipid raft microdomains. C. burnetii infection increased host cell cholesterol content by 1.75-fold with a coincident upregulation of host genes involved in cholesterol metabolism. Treatment with U18666A, lovastatin, or 25-hydroxycholesterol, pharmacological agents that inhibit cholesterol uptake and-or biosynthesis, altered PV morphology and partially inhibited C. burnetii replication. Complete inhibition of C. burnetii PV development and replication was observed when infected cells were treated with imipramine or ketoconazole, inhibitors of cholesterol uptake and biosynthesis respectively. We conclude that C. burnetii infection perturbs host cell cholesterol metabolism and that free access to host cholesterol stores is required for optimal C. burnetii replication. JF - Cellular Microbiology AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, rheinzen@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 496 EP - 507 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 8 IS - 3 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Vero cells KW - Replication KW - Cholesterol KW - Ketoconazole KW - Infection KW - Lipid rafts KW - Lipid metabolism KW - parasitophorous vacuole KW - Coxiella burnetii KW - Mammalian cells KW - imipramine KW - Vacuoles KW - Lovastatin KW - Evolution KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17172625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Coxiella+burnetii+inhabits+a+cholesterol-rich+vacuole+and+influences+cellular+cholesterol+metabolism&rft.au=Howe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2006-03-01&rft.volume=8&rft.issue=3&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2005.00641.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 7; references, 60. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Vero cells; Replication; Cholesterol; Infection; Ketoconazole; Lipid metabolism; Lipid rafts; parasitophorous vacuole; imipramine; Mammalian cells; Vacuoles; Evolution; Lovastatin; Coxiella burnetii DO - http://dx.doi.org/10.1111/j.1462-5822.2005.00641.x ER - TY - JOUR T1 - Case Reports: Successful Renal Transplantation in Patients with Chronic Granulomatous Disease AN - 17161484; 6760556 AB - Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population, and is often attributed to the necessary use of nephrotoxic anti-infectives. In this report, we present the experiences of two centers in transplantation of three patients with CGD: one transplanted with CGD, one cured of his CGD with bone marrow transplantation who subsequently underwent kidney transplantation and one that received a kidney transplant prior to being cured of CGD via a sequential peripheral blood stem cell transplant (SCT). All three recipients have enjoyed excellent outcomes. Their courses demonstrate the absolute requirements for a multidisciplinary and compulsive approach before, during and after transplantation. These case reports also highlight the unexpectedly benign effects of immunosuppressive therapy in this patient population. JF - American Journal of Transplantation AU - Bolanowski, A AU - Mannon, R B AU - Holland, S M AU - Malech, H L AU - Aschan, J AU - Palmblad, J AU - Hale, DA AU - Kirk, AD AD - Allan D. Kirk, AllanK@intra.niddk.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 636 EP - 639 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 6 IS - 3 SN - 1600-6135, 1600-6135 KW - NADPH oxidase KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Chronic granulomatous disease KW - kidney KW - transplant KW - Kidney transplantation KW - Immunodeficiency KW - Enzymes KW - Peripheral blood KW - Immunosuppressive agents KW - Case reports KW - NAD(P)H oxidase KW - Mutation KW - Bone marrow transplantation KW - Benign KW - End-stage renal disease KW - F 06204:Kidney KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17161484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Transplantation&rft.atitle=Case+Reports%3A+Successful+Renal+Transplantation+in+Patients+with+Chronic+Granulomatous+Disease&rft.au=Bolanowski%2C+A%3BMannon%2C+R+B%3BHolland%2C+S+M%3BMalech%2C+H+L%3BAschan%2C+J%3BPalmblad%2C+J%3BHale%2C+DA%3BKirk%2C+AD&rft.aulast=Bolanowski&rft.aufirst=A&rft.date=2006-03-01&rft.volume=6&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Transplantation&rft.issn=16006135&rft_id=info:doi/10.1111%2Fj.1600-6143.2006.01232.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - SuppNotes - References, 13. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Case reports; Kidney transplantation; Immunodeficiency; Enzymes; NAD(P)H oxidase; Peripheral blood; Chronic granulomatous disease; Mutation; Immunosuppressive agents; Bone marrow transplantation; End-stage renal disease; Benign DO - http://dx.doi.org/10.1111/j.1600-6143.2006.01232.x ER - TY - JOUR T1 - Assessing Weight-Related Quality of Life in Adolescents AN - 17147578; 6814659 AB - OBJECTIVE: The development of a new weight-related measure to assess quality of life in adolescents [Impact of Weight on Quality of Life (IWQOL)-Kids] is described. RESEARCH METHODS AND PROCEDURES: Using a literature search, clinical experience, and consultation with pediatric clinicians, 73 items were developed, pilot tested, and administered to 642 participants, 11 to 19 years old, recruited from weight loss programs/studies and community samples (mean z-BMI, 1.5; range, -1.2 to 3.4; mean age, 14.0; 60% female; 56% white). Participants completed the 73 items and the Pediatric Quality of Life Inventory and were weighed and measured. RESULTS: Four factors (27 items) were identified (physical comfort, body esteem, social life, and family relations), accounting for 71% of the variance. The IWQOL-Kids demonstrated excellent psychometric properties. Internal consistency coefficients ranged from 0.88 to 0.95 for scales and equaled 0.96 for total score. Convergent validity was demonstrated with strong correlations between IWQOL-Kids total score and the Pediatric Quality of Life Inventory (r = 0.76, p < 0.0001). Significant differences were found across BMI groups and between clinical and community samples, supporting the sensitivity of this measure. Participants in a weight loss camp demonstrated improved IWQOL-Kids scores, suggesting responsiveness of the IWQOL-Kids to weight loss/social support intervention. DISCUSSION: The present study provides preliminary evidence regarding the psychometric properties of the IWQOL-Kids, a weight-related quality of life measure for adolescents. Given the rise of obesity in youth, the development of a reliable and valid weight-related measure of quality of life is timely. JF - Obesity Research AU - Kolotkin, Ronette L AU - Zeller, Meg AU - Modi, Avani C AU - Samsa, Gregory P AU - Polanichka Quinlan, Nicole AU - Yanovski, Jack A AU - Bell, Stephen K AU - Maahs, David M AU - Gonzales de Serna, Daniela AU - Roehrig, Helmut R AD - Obesity and Quality of Life Consulting, Durham, North Carolina. Community and Family Medicine, Center for Clinical Health Policy Research, and. Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina. Division of Psychology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio. Department of Psychology, Social and Health Sciences, Duke University, Durham, North Carolina. Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Children's Health System, Children's Behavioral Health, Birmingham, Alabama. Barbara Davis Center for Diabetes, University of Colorado Health Sciences Center, Denver, Colorado. Department of Internal Medicine, University Hospital, Albuquerque, New Mexico Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 448 EP - 457 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 3 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Camps KW - Obesity KW - Measurement KW - Programs KW - Weight control KW - Pediatrics KW - Adolescence KW - Consultation KW - Validity KW - scoring KW - Lifestyle KW - Experience KW - Literature reviews KW - Social support KW - Family KW - Body concept KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Assessing+Weight-Related+Quality+of+Life+in+Adolescents&rft.au=Kolotkin%2C+Ronette+L%3BZeller%2C+Meg%3BModi%2C+Avani+C%3BSamsa%2C+Gregory+P%3BPolanichka+Quinlan%2C+Nicole%3BYanovski%2C+Jack+A%3BBell%2C+Stephen+K%3BMaahs%2C+David+M%3BGonzales+de+Serna%2C+Daniela%3BRoehrig%2C+Helmut+R&rft.aulast=Kolotkin&rft.aufirst=Ronette&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Camps; Measurement; Obesity; Programs; Weight control; Pediatrics; Consultation; Adolescence; Validity; Lifestyle; scoring; Experience; Social support; Literature reviews; Family; Body concept; Youth ER - TY - JOUR T1 - Cigarette Smoking and Lung Cancer: Modeling Total Exposure and Intensity AN - 17129101; 6752815 AB - Investigators typically analyze cigarette smoking using smoking duration and intensity (number of cigarettes smoked per day) as risk factors. However, odds ratios (OR) for categories of intensity either adjusted for, or jointly with, duration of smoking may be distorted by differences in total pack-years of exposure to cigarette smoke. To study effects of intensity, we apply a linear excess OR model to compare total exposure delivered at low intensity for a long period of time with an equal total exposure delivered at high intensity for a short period of time to data from a large case-control study of lung cancer. The excess OR per pack-year increases with intensity for subjects who smoke less than or equal to 20 cigarettes per day and decreases with intensity for subjects who smoke >20 cigarettes per day. The intensity patterns are homogeneous by histologic type of lung cancer, suggesting that observed differences in risks by histologic type are related to total smoking exposure or smoking duration and not smoking intensity. At lower smoking intensities, there is an "exposure enhancement" effect such that for equal total exposure, the excess OR per pack-year increases with intensity. At higher smoking intensities, there is a "reduced potency" or "wasted exposure" effect such that for equal total exposure, the excess OR per pack-year decreases with intensity (i.e., smoking at a lower intensity for longer duration is more deleterious than smoking at a higher intensity for shorter duration). (Cancer Epidemiol Biomarkers Prev 2006; 15(3):517-23) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Lubin, Jay H AU - Caporaso, Neil E AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 517 EP - 523 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - Toxicology Abstracts KW - Smoke KW - Mathematical models KW - Risk factors KW - Cigarette smoking KW - Cigarette smoke KW - biomarkers KW - Lung cancer KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17129101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Cigarette+Smoking+and+Lung+Cancer%3A+Modeling+Total+Exposure+and+Intensity&rft.au=Lubin%2C+Jay+H%3BCaporaso%2C+Neil+E&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoke; Mathematical models; Risk factors; Cigarette smoking; Cigarette smoke; biomarkers; Lung cancer ER - TY - JOUR T1 - Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene AN - 17126767; 6746665 AB - Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable with wild-type murine p53; however, transactivation, induction of apoptosis, and G sub(1)-S checkpoint, but not transrepression or regulation of a centrosomal checkpoint, were deregulated. Although multiple functions of p53 were abrogated, mice carrying the human p53 transgene did not show early onset of tumors as typically seen for p53-null mice. In contrast, human p53 in the p53-null background did not prevent accelerated tumor development after genotoxic or oncogenic stress. Such behavior of human p53 expressed at physiologic levels in transgenic cells could be explained by unexpectedly high binding with Mdm2. By using Nutlin-3a, an inhibitor of the interaction between Mdm2 and p53, we were able to partially reconstitute p53 transactivation and apoptosis in transgenic cells. Our findings indicate that the interaction between p53 and Mdm2 controls p53 transcriptional activity in homeostatic tissues and regulates DNA damage- and oncogene-induced, but not spontaneous, tumorigenesis.(Cancer Res 2006; 66(6): 2928-36) JF - Cancer Research AU - Dudgeon, Crissy AU - Kek, Calvina AU - Demidov, Oleg N AU - Saito, Shin-ichi AU - Fernandes, Kenneth AU - Diot, Alexandra AU - Bourdon, Jean-Christophe AU - Lane, David P AU - Appella, Ettore AU - Fornace, Albert JJr AU - Bulavin, Dmitry V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 2928 EP - 2936 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 6 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - MDM2 protein KW - Tumor suppressor genes KW - Apoptosis KW - Genotoxicity KW - Stress KW - Transcription KW - Tumors KW - Transgenic mice KW - p53 protein KW - DNA KW - W 30925:Genetic Engineering KW - B 26670:Tumor Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17126767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Tumor+Susceptibility+and+Apoptosis+Defect+in+a+Mouse+Strain+Expressing+a+Human+p53+Transgene&rft.au=Dudgeon%2C+Crissy%3BKek%2C+Calvina%3BDemidov%2C+Oleg+N%3BSaito%2C+Shin-ichi%3BFernandes%2C+Kenneth%3BDiot%2C+Alexandra%3BBourdon%2C+Jean-Christophe%3BLane%2C+David+P%3BAppella%2C+Ettore%3BFornace%2C+Albert+JJr%3BBulavin%2C+Dmitry+V&rft.aulast=Dudgeon&rft.aufirst=Crissy&rft.date=2006-03-01&rft.volume=66&rft.issue=6&rft.spage=2928&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - p53 protein; Apoptosis; MDM2 protein; Tumors; Transcription; Stress; Transgenic mice; DNA; Tumor suppressor genes; Genotoxicity ER - TY - JOUR T1 - Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state AN - 17121342; 6749332 AB - We have used a bioinformatic approach to predict the natural substrate proteins for the Escherichia coli chaperonin GroEL based on two simple criteria. Natural substrate proteins should contain binding motifs similar in sequence to the mobile loop peptide of GroES that displaces the binding motif during the chaperonin cycle. Secondly, each substrate protein should contain multiple copies of the binding motif so that the chaperonin can perform "work" on the substrate protein. To validate these criteria, we have used a database of 252 proteins that have been experimentally shown to interact with the chaperonin machinery in vivo. More than 80% are identified by these criteria. The binding motifs of all 79 proteins in the database with a known three-dimensional structure are buried (<50% solvent-accessible surface area) in the native state. Our results show that the binding motifs are inaccessible in the native state but become solvent-exposed in unfolded state, thus enabling GroEL to distinguish between unfolded and native states. The structures of the binding motif in the native states of the substrate proteins include alpha -helices, beta -strands, and random coils. The diversity of secondary structures implies that there are large and varied conformational transitions in the recognition motifs after their displacement by the mobile loops of GroES. JF - Proceedings of the National Academy of Sciences, USA AU - Stan, George AU - Brooks, Bernard R AU - Lorimer, George H AU - Thirumalai, D AD - Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 4433 EP - 4438 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 12 SN - 0027-8424, 0027-8424 KW - GroEL protein KW - Microbiology Abstracts B: Bacteriology KW - Protein structure KW - Databases KW - Surface area KW - Chaperonins KW - Secondary structure KW - Escherichia coli KW - Bioinformatics KW - Random coil KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17121342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Residues+in+substrate+proteins+that+interact+with+GroEL+in+the+capture+process+are+buried+in+the+native+state&rft.au=Stan%2C+George%3BBrooks%2C+Bernard+R%3BLorimer%2C+George+H%3BThirumalai%2C+D&rft.aulast=Stan&rft.aufirst=George&rft.date=2006-03-01&rft.volume=103&rft.issue=12&rft.spage=4433&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein structure; Databases; Surface area; Secondary structure; Chaperonins; Bioinformatics; Random coil; Escherichia coli ER - TY - JOUR T1 - Solution Structure of a Post-transition State Analog of the Phosphotransfer Reaction between the A and B Cytoplasmic Domains of the Mannitol Transporter II super(Mannitol) of the Escherichia coli Phosphotransferase System AN - 17113145; 6747791 AB - The solution structure of the post-transition state complex between the isolated cytoplasmic A (IIA super(Mtl)) and phosphorylated B (phospho-IIB super(Mtl)) domains of the mannitol transporter of the Escherichia coli phosphotransferase system has been solved by NMR. The active site His-554 of IIA super(Mtl) was mutated to glutamine to block phosphoryl transfer activity, and the active site Cys-384 of IIB super(Mtl) (residues of IIB super(Mtl) are denoted in italic type) was substituted by serine to permit the formation of a stable phosphorylated form of IIB super(Mtl). The two complementary interaction surfaces are predominantly hydrophobic, and two methionines on IIB super(Mtl), Met-388 and Met-393, serve as anchors by interacting with two deep pockets on the surface of IIA super(Mtl). With the exception of a salt bridge between the conserved Arg-538 of IIA super(Mtl) and the phosphoryl group of phospho-IIB super(Mtl), electrostatic interactions between the two proteins are limited to the outer edges of the interface, are few in number, and appear to be weak. This accounts for the low affinity of the complex (K sub(d) similar to 3.7 mM), which is optimally tuned to the intact biological system in which the A and B domains are expressed as a single polypeptide connected by a flexible 21-residue linker. The phosphoryl transition state can readily be modeled with no change in protein-protein orientation and minimal perturbations in both the backbone immediately adjacent to His-554 and Cys-384 and the side chains in close proximity to the phosphoryl group. Comparison with the previously solved structure of the IIA super(Mtl)-HPr complex reveals how IIA super(Mtl) uses the same interaction surface to recognize two structurally unrelated proteins and explains the much higher affinity of IIA super(Mtl) for HPr than IIB super(Mtl) JF - Journal of Biological Chemistry AU - Suh, Jeong-Yong AU - Cai, Mengli AU - Williams, David CJr AU - Clore, GMarius AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 8939 EP - 8949 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 13 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Salts KW - Glutamine KW - Mannitol KW - Escherichia coli KW - N.M.R. KW - Hydrophobicity KW - phosphotransferase KW - Serine KW - Methionine KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17113145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Solution+Structure+of+a+Post-transition+State+Analog+of+the+Phosphotransfer+Reaction+between+the+A+and+B+Cytoplasmic+Domains+of+the+Mannitol+Transporter+II+super%28Mannitol%29+of+the+Escherichia+coli+Phosphotransferase+System&rft.au=Suh%2C+Jeong-Yong%3BCai%2C+Mengli%3BWilliams%2C+David+CJr%3BClore%2C+GMarius&rft.aulast=Suh&rft.aufirst=Jeong-Yong&rft.date=2006-03-01&rft.volume=281&rft.issue=13&rft.spage=8939&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Salts; Glutamine; Mannitol; Hydrophobicity; N.M.R.; phosphotransferase; Methionine; Serine; Escherichia coli ER - TY - JOUR T1 - In Vitro Reconstitution of Catabolite Repression in Escherichia coli AN - 17112235; 6747509 AB - A widely accepted model for catabolite repression posits that phospho-IIA super(Glc) of the bacterial phosphotransferase system activates adenylyl cyclase (AC) activity. For many years, attempts to observe such regulatory properties of AC in vitro have been unsuccessful. To further study the regulation, AC was produced fused to the transmembrane segments of the serine chemoreceptor Tsr. Cells harboring Tsr-AC and normal AC, expressed from the cya promoter on a low copy number vector, exhibit similar behavior with respect to elevation of cAMP levels resulting from deletion of crp, expressing the catabolite regulatory protein. Membrane-bound Tsr-AC exhibits activity comparable with the native form of AC. Tsr-AC binds IIA super(Glc) specifically, regardless of its phosphorylation state, but not the two general phosphotransferase system proteins, enzyme I and HPr; IIA super(Glc) binding is localized to the C-terminal region of AC. Binding to membranes of either dephospho- or phospho-IIA super(Glc) has no effect on AC activity. However, in the presence of an Escherichia coli extract, P-IIA super(Glc), but not IIA super(Glc), stimulates AC activity. Based on these findings of a direct interaction of IIA super(Glc) with AC, but activity regulation only in the presence of E. coli extract, a revised model for AC activity regulation is proposed. JF - Journal of Biological Chemistry AU - Park, Young-Ha AU - Lee, Byeong R AU - Seok, Yeong-Jae AU - Peterkofsky, Alan AD - Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 151-742, Korea, the Department of Biology, Seowon University, Chongju City 361-742, Korea, and the Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-8017 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 6448 EP - 6454 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 10 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Chemoreceptors KW - Clonal deletion KW - Catabolites KW - Cyclic AMP KW - Enzyme I KW - phosphotransferase KW - copy number KW - Promoters KW - Gene deletion KW - regulatory proteins KW - Phosphorylation KW - Escherichia coli KW - Catabolite repression KW - Serine KW - Adenylate cyclase KW - J 02721:Cell cycle, morphology and motility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17112235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=In+Vitro+Reconstitution+of+Catabolite+Repression+in+Escherichia+coli&rft.au=Park%2C+Young-Ha%3BLee%2C+Byeong+R%3BSeok%2C+Yeong-Jae%3BPeterkofsky%2C+Alan&rft.aulast=Park&rft.aufirst=Young-Ha&rft.date=2006-03-01&rft.volume=281&rft.issue=10&rft.spage=6448&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemoreceptors; Clonal deletion; Catabolites; Cyclic AMP; Enzyme I; phosphotransferase; copy number; Promoters; Gene deletion; Phosphorylation; regulatory proteins; Catabolite repression; Serine; Adenylate cyclase; Escherichia coli ER - TY - JOUR T1 - A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection AN - 17107447; 6742383 AB - West Nile virus (WNV) is a neurotropic flavivirus within the Japanese encephalitis antigenic complex that is responsible for causing West Nile encephalitis in humans. The surface of WNV virions is covered by a highly ordered icosahedral array of envelope proteins that is responsible for mediating attachment and fusion with target cells. These envelope proteins are also primary targets for the generation of neutralizing antibodies in vivo. In this study, we describe a novel approach for measuring antibody-mediated neutralization of WNV infection using virus-like particles that measure infection as a function of reporter gene expression. These reporter virus particles (RVPs) are produced by complementation of a sub-genomic replicon with WNV structural proteins provided in trans using conventional DNA expression vectors. The precision and accuracy of this approach stem from an ability to measure the outcome of the interaction between antibody and viral antigens under conditions that satisfy the assumptions of the law of mass action as applied to virus neutralization. In addition to its quantitative strengths, this approach allows the production of WNV RVPs bearing the prM-E proteins of different WNV strains and mutants, offering considerable flexibility for the study of the humoral immune response to WNV in vitro. WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody. JF - Virology AU - Pierson, T C AU - Sanchez, MD AU - Puffer, BA AU - Ahmed, A A AU - Geiss, B J AU - Valentine, LE AU - Altamura, LA AU - Diamond AU - Doms, R W AD - University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, piersontc@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 53 EP - 65 VL - 346 IS - 1 SN - 0042-6822, 0042-6822 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Virions KW - Virology KW - Virus-like particles KW - Immunity KW - Infection KW - Flavivirus KW - Structural proteins KW - Encephalitis KW - Public health KW - Disease transmission KW - Expression vectors KW - Gene expression KW - Japanese encephalitis KW - Antibodies KW - Complementation KW - Antigens KW - Viral diseases KW - Reporter gene KW - Envelope protein KW - DNA KW - Immune response (humoral) KW - West Nile virus KW - Q1 08205:Genetics and evolution KW - V 22091:Immunological techniques & reagents KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17107447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=A+rapid+and+quantitative+assay+for+measuring+antibody-mediated+neutralization+of+West+Nile+virus+infection&rft.au=Pierson%2C+T+C%3BSanchez%2C+MD%3BPuffer%2C+BA%3BAhmed%2C+A+A%3BGeiss%2C+B+J%3BValentine%2C+LE%3BAltamura%2C+LA%3BDiamond%3BDoms%2C+R+W&rft.aulast=Pierson&rft.aufirst=T&rft.date=2006-03-01&rft.volume=346&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2005.10.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Virology; Gene expression; Antibodies; Antigens; Viral diseases; Immunity; Disease transmission; Public health; Virions; Virus-like particles; Infection; Encephalitis; Structural proteins; Expression vectors; Japanese encephalitis; Complementation; Reporter gene; Envelope protein; DNA; Immune response (humoral); West Nile virus; Flavivirus DO - http://dx.doi.org/10.1016/j.virol.2005.10.030 ER - TY - JOUR T1 - HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane AN - 17105899; 6742377 AB - We examined the association of HTLV-1 Gag with tetraspanin-enriched microdomains in the plasma membrane. Immunofluorescent staining and confocal image analysis showed that HTLV-1 Gag protein colocalized with CD82 and other tetraspanins at the plasma membrane of T cells. HTLV-1 Gag, which is associated with the inner surface of the plasma membrane, was concentrated to the patches formed by antibody-mediated cross-linking of CD82 on the cell surface. Also, CD82 and HTLV-1 Gag rapidly segregated to the immune synapse that is formed between Raji B cells and Jurkat T cells in the presence of bacterial superantigen. CD82, which was immunoprecipitated from cell extracts prepared in Brij97 detergent conditions, was associated with the matrix (MA) protein. Stable interaction of MA and CD82 in Brij97-disrupted cell extracts required Gag multimerization and proteolytic processing. The form of MA that coimmunoprecipitated with CD82 was a cysteine-linked homodimer. The viral envelope glycoprotein was not required for the association of Gag with CD82-enriched membrane regions. In contrast to HTLV-1, HIV-1 Gag did not colocalize, cosegregate, or coimmunoprecipitate with CD82. Our data suggest that once at the plasma membrane, HTLV-1 virion components associate with CD82-containing microdomains, which may facilitate the mobilization of nascent virions to sites of intercellular adhesion. JF - Virology AU - Mazurov, D AU - Heidecker, G AU - Derse, D AD - HIV Drug Resistance Program, Bld 535, Rm. 110, NCI-Frederick, Frederick, MD 21702-1201, USA, derse@ncifcrf.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 194 EP - 204 VL - 346 IS - 1 SN - 0042-6822, 0042-6822 KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Proteolysis KW - Virions KW - Cell surface KW - Data processing KW - Detergents KW - Lymphocytes B KW - Human T-lymphotropic virus 1 KW - Image processing KW - Gag protein KW - Cell adhesion KW - Superantigens KW - Envelopes KW - Plasma membranes KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Glycoproteins KW - Immunological synapses KW - J 02330:Biochemistry KW - V 22042:Adsorption, penetration & uncoating UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17105899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=HTLV-1+Gag+protein+associates+with+CD82+tetraspanin+microdomains+at+the+plasma+membrane&rft.au=Mazurov%2C+D%3BHeidecker%2C+G%3BDerse%2C+D&rft.aulast=Mazurov&rft.aufirst=D&rft.date=2006-03-01&rft.volume=346&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2005.10.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Proteolysis; Cell surface; Data processing; Lymphocytes B; Detergents; Image processing; Gag protein; Cell adhesion; Superantigens; Envelopes; Plasma membranes; Lymphocytes T; Glycoproteins; Immunological synapses; Human immunodeficiency virus 1; Human T-lymphotropic virus 1 DO - http://dx.doi.org/10.1016/j.virol.2005.10.033 ER - TY - JOUR T1 - SMC complexes in bacterial chromosome condensation and segregation AN - 17092940; 6722040 AB - Bacterial chromosomes segregate via a partition apparatus that employs a score of specialized proteins. The SMC complexes play a crucial role in the chromosome partitioning process by organizing bacterial chromosomes through their ATP-dependent chromatin-compacting activity. Recent progress in the composition of these complexes and elucidation of their structural and enzymatic properties has advanced our comprehension of chromosome condensation and segregation mechanics in bacteria. egregation mechanics in bacteria. JF - Plasmid AU - Strunnikov, A V AD - NICHD, Bethesda, MD, USA, strunnik@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 135 EP - 144 PB - Elsevier Inc. VL - 55 IS - 2 SN - 0147-619X, 0147-619X KW - SMC protein KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Bacteria KW - Chromosomes KW - Condensation KW - Plasmids KW - G 07203:Plasmids KW - A 01300:Methods KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17092940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=SMC+complexes+in+bacterial+chromosome+condensation+and+segregation&rft.au=Strunnikov%2C+A+V&rft.aulast=Strunnikov&rft.aufirst=A&rft.date=2006-03-01&rft.volume=55&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2005.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; Condensation; Plasmids; Bacteria DO - http://dx.doi.org/10.1016/j.plasmid.2005.08.004 ER - TY - JOUR T1 - Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen AN - 17090834; 6725886 AB - Four single-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal factor (LF) of anthrax were isolated from a phage display library generated from immunized chimpanzees. Only 2 scFvs recognizing PA (Wl and W2) neutralized the cytotoxicity of lethal toxin in a macrophage lysis assay. Full-length immunoglobulin G (IgG) of W1 and W2 efficiently protected rats from anthrax toxin challenge. The epitope recognized by W1 and W2 was conformational and was formed by C-terminal amino acids 614-735 of PA. W1 and W2 each bound to PA with an equilibrium dissociation constant of 4 x 10 super(-11) mol/L to 5 x 10 super(-11) mol/L, which is an affinity that is 20-100-fold higher than that for the interaction of the receptor and PA. W1 and W2 inhibited the binding of PA to the receptor, suggesting that this was the mechanism of protection. These data suggest that W1 and W2 chimpanzee monoclonal antibodies may serve as PA entry inhibitors for use in the emergency prophylaxis against and treatment of anthrax. JF - Journal of Infectious Diseases AU - Chen, Z AU - Moayeri, M AU - Zhou, Y-H AU - Leppla, S AU - Emerson, S AU - Sebrell, A AU - Yu, F AU - Svitel, J AU - Schuck, P AU - Claire AU - Purcell, R AD - Hepatitis Viruses Section and Molecular Hepatitis Section, Laboratory of Infectious Diseases, and Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, and Protein Biophysics Resource, National Institutes of Health, Bethesda, and Bioqual, Rockville, Maryland, USA Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 625 EP - 633 VL - 193 IS - 5 SN - 0022-1899, 0022-1899 KW - Chimpanzee KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Amino acids KW - Data processing KW - Monoclonal antibodies KW - Lethal factor KW - Phage display KW - C-Terminus KW - protective antigen KW - Bacillus anthracis KW - Fv KW - Toxins KW - Pan troglodytes KW - Cytotoxicity KW - Prophylaxis KW - Immunoglobulin G KW - Anthrax KW - Epitopes KW - Amino acid sequence KW - J 02832:Antigenic properties and virulence KW - X 24370:Natural Toxins KW - F 06700:Monoclonal antibodies, hybridoma, antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17090834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Efficient+Neutralization+of+Anthrax+Toxin+by+Chimpanzee+Monoclonal+Antibodies+against+Protective+Antigen&rft.au=Chen%2C+Z%3BMoayeri%2C+M%3BZhou%2C+Y-H%3BLeppla%2C+S%3BEmerson%2C+S%3BSebrell%2C+A%3BYu%2C+F%3BSvitel%2C+J%3BSchuck%2C+P%3BClaire%3BPurcell%2C+R&rft.aulast=Chen&rft.aufirst=Z&rft.date=2006-03-01&rft.volume=193&rft.issue=5&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Data processing; Amino acids; Monoclonal antibodies; Lethal factor; protective antigen; C-Terminus; Phage display; Toxins; Fv; Cytotoxicity; Immunoglobulin G; Prophylaxis; Anthrax; Epitopes; Amino acid sequence; Bacillus anthracis; Pan troglodytes ER - TY - JOUR T1 - Effective Dosing of Lipid A Analogue E5564 in Rats Depends on the Timing of Treatment and the Route of Escherichia coli Infection AN - 17090326; 6725887 AB - Background. E5564, a competitive lipid A antagonist, inhibits endotoxin-stimulated inflammation and is under study in patients with sepsis. Methods. We tested whether clinically relevant variables, including the timing of treatment and the route of infection, influenced the effective dosing of E5564 in Escherichia coli-challenged rats. Results. All E5564 doses (0.3, 1.0, 2.0, and 3.0 mg/kg intravascular bolus followed by 10% of the bolus dose infused hourly for 24 h) administered 1 h before intravascular E. coli challenge similarly reduced the risk of death. Delaying the start of E5564 to 1 or 3 h after intravascular E. coli challenge significantly reduced the beneficial effect of the doses tested. However, increasing the dose of E5564 reversed some loss of efficacy for delayed treatment (P = .004, for increasing benefit with increasing dose at 1 h). During intrabronchial or intraperitoneal (extravascular) E. coli challenge, the pattern of effective E5564 dosing was the inverse of that for intravascular E. coli challenge (P = .001, for the interaction)-- lower doses of E5564 were beneficial and higher doses were not (0.03, 0.3, 1.0, 2.0, and 3.0 mg/kg bolus followed by infusion) (P = .05, for decreasing benefit with increasing dose at 1 h). Conclusion. These findings suggest that, for maximal clinical benefit, E5564 should be given early and that dosing should be adjusted upward for intravascular infection and downward for extravascular infection. JF - Journal of Infectious Diseases AU - Solomon, S B AU - Cui, X AU - Gerstenberger, E AU - Danner, R L AU - Fitz, Y AU - Banks, S M AU - Natanson, C AU - Eichacker, P Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 634 EP - 644 VL - 193 IS - 5 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Sepsis KW - Escherichia coli KW - Lipid A KW - Inflammation KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17090326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Effective+Dosing+of+Lipid+A+Analogue+E5564+in+Rats+Depends+on+the+Timing+of+Treatment+and+the+Route+of+Escherichia+coli+Infection&rft.au=Solomon%2C+S+B%3BCui%2C+X%3BGerstenberger%2C+E%3BDanner%2C+R+L%3BFitz%2C+Y%3BBanks%2C+S+M%3BNatanson%2C+C%3BEichacker%2C+P+Q&rft.aulast=Solomon&rft.aufirst=S&rft.date=2006-03-01&rft.volume=193&rft.issue=5&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Sepsis; Lipid A; Inflammation; Escherichia coli ER - TY - JOUR T1 - Preclinical Perspectives on Garlic and Cancer AN - 17089327; 6714683 AB - Evidence continues to point to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds generated by processing garlic. These anticarcinogenic and antitumorigenic characteristics appear to arise through both dose- and temporal-related changes in a number of cellular events involved with the cancer process, including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis, and angiogenesis. The ability of garlic and related allyl sulfur compounds to block tumors in the colon, lung, breast, and liver suggests general mechanisms that are not tissue specific. Whereas relatively few studies have compared the relative efficacy of water- and lipid-soluble allyl sulfur compounds, those that have when using chemically induced carcinogen models suggest little difference in response, whereas tumor proliferation/apoptosis is highly dependent on the species provided. A shift in sulfhydryl groups, alterations in glutathione:oxidized glutathione ratios, and resultant changes in cellular redox status may be involved in some of the phenotypic changes caused by allyl sulfur compounds. Such changes in thiols by allyl sulfurs may also account for the observed hyperphosphorylation of specific cell cycle proteins and the histone hyperacetylation that has been correlated with suppressed tumor cell proliferation. Whereas the anticarcinogenic and antitumorigenic data to date are impressive, additional studies are needed with more modest exposure to allyl sulfur compounds over prolonged periods. Likewise, additional studies are needed that incorporate transgenic and knockout models to assist in the identification of molecular targets for garlic and its associated allyl sulfur components. JF - Journal of Nutrition AU - Milner, John A AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20854 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 827S EP - 831S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 3 SN - 0022-3166, 0022-3166 KW - garlic KW - Risk Abstracts KW - Diets KW - Allium sativum KW - Liver KW - Proteins KW - Risk reduction KW - Nutrition KW - Cancer KW - Metabolism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17089327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Preclinical+Perspectives+on+Garlic+and+Cancer&rft.au=Milner%2C+John+A&rft.aulast=Milner&rft.aufirst=John&rft.date=2006-03-01&rft.volume=136&rft.issue=3&rft.spage=827S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Liver; Proteins; Risk reduction; Nutrition; Metabolism; Cancer; Allium sativum ER - TY - JOUR T1 - Effects of Lipid Formulations of Amphotericin B on Activity of Human Monocytes against Aspergillus fumigatus AN - 17087977; 6715631 AB - The immunomodulatory effects of liposomal amphotericin B (LAMB), amphotericin B lipid complex, and amphotericin B colloidal dispersion (ABCD) on antifungal activity of human monocytes (MNCs), an important component of antifungal host defense, against Aspergillus fumigatus were compared to those of deoxycholate amphotericin B (DAMB). MNCs from healthy volunteers were incubated with 1 or 5 mu g/ml DAMB and 5 or 25 mu g/ml lipid formulations for 22 h. Drug-pretreated or untreated MNCs were then washed and assayed for the following: (i) activity against A. fumigatus hyphae by XTT assay at MNC:hypha ratios of 10:1 and 20:1; (ii) production of superoxide anion (O sub(2) super(-)) from MNCs in response to hyphae by cytochrome c reduction; (iii) production of hydrogen peroxide (H sub(2)O sub(2)) and H sub(2)O sub(2)-dependent intracellular intermediates (DIIs), such as OH super(-) and HOCl, from MNCs in response to A. fumigatus culture supernatant by flow cytometric measurement of dihydrorhodamine-1,2,3 oxidation. With the exception of 1 mu g/ml DAMB and 5 mu g/ml LAMB or ABCD at 10:1, all amphotericin B formulations at both concentrations and MNC:hypha ratios enhanced MNC-induced damage of A. fumigatus hyphae compared to results with untreated cells (P < 0.01). While MNC O sub(2) super(-) production upon hyphal challenge, an early event in oxidative burst, was not affected by the drugs, production of H sub(2)O sub(2) and DIIs, late events, were significantly increased by all four drugs (P < 0.01). At clinically relevant concentrations, both conventional amphotericin B and its lipid formulations enhance antihyphal activity of MNCs against A. fumigatus in association with significant augmentation of H sub(2)O sub(2) and DIIs but not O sub(2) super(-), further demonstrating the immunomodulatory antifungal activities of these agents. JF - Antimicrobial Agents & Chemotherapy AU - Dotis, J AU - Simitsopoulou, M AU - Dalakiouridou, M AU - Konstantinou, T AU - Taparkou, A AU - Kanakoudi-Tsakalidou, F AU - Walsh, T J AU - Roilides, E AD - Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece. Laboratory of Clinical Immunology, 1st Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 868 EP - 873 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amphotericin B KW - Lipids KW - Hyphae KW - Cell culture KW - Antimicrobial agents KW - Cytochrome c KW - Hydrogen peroxide KW - Aspergillus fumigatus KW - Antifungal activity KW - Oxidation KW - superoxide anions KW - Monocytes KW - Drugs KW - A 01067:Antifungal & fungicidal KW - K 03063:Effects of physical & chemical factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effects+of+Lipid+Formulations+of+Amphotericin+B+on+Activity+of+Human+Monocytes+against+Aspergillus+fumigatus&rft.au=Dotis%2C+J%3BSimitsopoulou%2C+M%3BDalakiouridou%2C+M%3BKonstantinou%2C+T%3BTaparkou%2C+A%3BKanakoudi-Tsakalidou%2C+F%3BWalsh%2C+T+J%3BRoilides%2C+E&rft.aulast=Dotis&rft.aufirst=J&rft.date=2006-03-01&rft.volume=50&rft.issue=3&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Cytochrome c; Hydrogen peroxide; Lipids; Oxidation; Antifungal activity; Hyphae; superoxide anions; Cell culture; Monocytes; Drugs; Antimicrobial agents; Aspergillus fumigatus ER - TY - JOUR T1 - Human Immunodeficiency Virus (HIV) Vaccine Trials: a Novel Assay for Differential Diagnosis of HIV Infections in the Face of Vaccine-Generated Antibodies AN - 17087780; 6714736 AB - All current human immunodeficiency virus (HIV) vaccine candidates contain multiple viral components and elicit antibodies that react positively in licensed HIV diagnostic tests, which contain similar viral products. Thus, vaccine trial participants could be falsely diagnosed as infected with HIV. Additionally, uninfected, seropositive vaccinees may encounter long-term social and economic harms. Moreover, this also interferes with early detection of true HIV infections during preventive HIV vaccine trials. An HIV-seropositive test result among uninfected vaccine trial participants is a major public health concern for volunteers who want to participate in future HIV vaccine trials. Based on the increased number of HIV vaccines being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Using a whole-HIV-genome phage display library, we identified conserved sequences in Env-gp41 and Gag-p6 which are recognized soon after infection, do not contain protective epitopes, and are not part of most current HIV vaccines. We established a new HIV serodetection assay based on these peptides. To date, this assay, termed HIV-SELECTEST, demonstrates >99% specificity and sensitivity. Importantly, in testing of plasma samples from multiple HIV vaccine trials, uninfected trial participants scored negative, while all intercurrent infections were detected within 1 to 3 months of HIV infection. The new HIV-SELECTEST is a simple but robust diagnostic tool for easy implementation in HIV vaccine trials and blood banks worldwide. JF - Journal of Virology AU - Khurana, Surender AU - Needham, James AU - Mathieson, Bonnie AU - Rodriguez-Chavez, Isaac R AU - Catanzaro, Andrew T AU - Bailer, Robert T AU - Kim, Jerome AU - Polonis, Vicky AU - Cooper, David A AU - Guerin, Jan AU - Peterson, Michael L AU - Gurwith, Marc AU - Nguyen, Nga AU - Graham, Barney S AU - Golding, Hana AD - Division of Viral Products. Core Facility, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, Maryland 20892. Office of AIDS Research, NIH, Bethesda, Maryland 20892. Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. U.S. Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), APO AP 96546. U.S. Military HIV Research Program, Rockville, Maryland 20850. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia 2010. VaxGen, Inc., Brisbane, California 94005 Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 2092 EP - 2099 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 5 SN - 0022-538X, 0022-538X KW - HIV KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Public health KW - Economics KW - Epitopes KW - Phage display KW - Blood KW - Antibodies KW - Differential diagnosis KW - Human immunodeficiency virus KW - Vaccines KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - V 22003:AIDS: Immunological aspects KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Human+Immunodeficiency+Virus+%28HIV%29+Vaccine+Trials%3A+a+Novel+Assay+for+Differential+Diagnosis+of+HIV+Infections+in+the+Face+of+Vaccine-Generated+Antibodies&rft.au=Khurana%2C+Surender%3BNeedham%2C+James%3BMathieson%2C+Bonnie%3BRodriguez-Chavez%2C+Isaac+R%3BCatanzaro%2C+Andrew+T%3BBailer%2C+Robert+T%3BKim%2C+Jerome%3BPolonis%2C+Vicky%3BCooper%2C+David+A%3BGuerin%2C+Jan%3BPeterson%2C+Michael+L%3BGurwith%2C+Marc%3BNguyen%2C+Nga%3BGraham%2C+Barney+S%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2006-03-01&rft.volume=80&rft.issue=5&rft.spage=2092&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Vaccines; Antibodies; Public health; Phage display; Blood; Economics; Differential diagnosis; Epitopes ER - TY - JOUR T1 - A Single Intranasal Inoculation with a Paramyxovirus-Vectored Vaccine Protects Guinea Pigs against a Lethal-Dose Ebola Virus Challenge AN - 17087609; 6714753 AB - To determine whether intranasal inoculation with a paramyxovirus-vectored vaccine can induce protective immunity against Ebola virus (EV), recombinant human parainfluenza virus type 3 (HPIV3) was modified to express either the EV structural glycoprotein (GP) by itself (HPIV3/EboGP) or together with the EV nucleoprotein (NP) (HPIV3/EboGP-NP). Expression of EV GP by these recombinant viruses resulted in its efficient incorporation into virus particles and increased cytopathic effect in Vero cells. HPIV3/EboGP was 100-fold more efficiently neutralized by antibodies to EV than by antibodies to HPIV3. Guinea pigs infected with a single intranasal inoculation of 10 super(5.3) PFU of HPIV3/EboGP or HPIV3/EboGP-NP showed no apparent signs of disease yet developed a strong humoral response specific to the EV proteins. When these animals were challenged with an intraperitoneal injection of 10 super(3) PFU of EV, there were no outward signs of disease, no viremia or detectable EV antigen in the blood, and no evidence of infection in the spleen, liver, and lungs. In contrast, all of the control animals died or developed severe EV disease following challenge. The highly effective immunity achieved with a single vaccine dose suggests that intranasal immunization with live vectored vaccines based on recombinant respiratory viruses may be an advantageous approach to inducing protective responses against severe systemic infections, such as those caused by hemorrhagic fever agents. JF - Journal of Virology AU - Bukreyev, Alexander AU - Yang, Lijuan AU - Zaki, Sherif R AU - Shieh, Wun-Ju AU - Rollin, Pierre E AU - Murphy, Brian R AU - Collins, Peter L AU - Sanchez, Anthony AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 2267 EP - 2279 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 5 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Disseminated infection KW - Nucleoproteins KW - Ebola virus KW - Parainfluenza KW - Parainfluenza virus KW - Glycoproteins KW - Vero cells KW - Spleen KW - Paramyxovirus KW - Immunity KW - Antibody response KW - Blood KW - Hemorrhagic fever KW - Viremia KW - Vaccines KW - W3 33365:Vaccines (other) KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A+Single+Intranasal+Inoculation+with+a+Paramyxovirus-Vectored+Vaccine+Protects+Guinea+Pigs+against+a+Lethal-Dose+Ebola+Virus+Challenge&rft.au=Bukreyev%2C+Alexander%3BYang%2C+Lijuan%3BZaki%2C+Sherif+R%3BShieh%2C+Wun-Ju%3BRollin%2C+Pierre+E%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L%3BSanchez%2C+Anthony&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2006-03-01&rft.volume=80&rft.issue=5&rft.spage=2267&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ebola virus; Parainfluenza virus; Paramyxovirus; Vaccines; Antibody response; Immunity; Hemorrhagic fever; Blood; Parainfluenza; Vero cells; Viremia; Spleen; Glycoproteins; Nucleoproteins; Disseminated infection ER - TY - JOUR T1 - Delta super(9)-Tetrahydrocannabinol and Endogenous Cannabinoid Anandamide Directly Potentiate the Function of Glycine Receptors AN - 17086411; 6714886 AB - Anandamide (AEA) and Delta super(9)-tetrahydrocannabinol (THC) are endogenous and exogenous ligands, respectively, for cannabinoid receptors. Whereas most of the pharmacological actions of cannabinoids are mediated by CB1 receptors, there is also evidence that these compounds can produce effects that are not mediated by the activation of identified cannabinoid receptors. Here, we report that THC and AEA, in a CB1 receptor-independent manner, cause a significant potentiation of the amplitudes of glycine-activated currents (I sub(Gly)) in acutely isolated neurons from rat ventral tegmental area (VTA) and in Xenopus laevis oocytes expressing human homomeric ( alpha 1) and heteromeric ( alpha 1 beta 1) subunits of glycine receptors (GlyRs). The potentiation of I sub(Gly) by THC and AEA is concentration-dependent, with respective EC sub(50) values of 86 plus or minus 9 and 319 plus or minus 31 nM for alpha 1 homomeric receptors, 73 plus or minus 8 and 318 plus or minus 24 nM for alpha 1 beta 1 heteromeric receptors, and 115 plus or minus 13 and 230 plus or minus 29 nM for native GlyRs in VTA neurons. The effects of THC and AEA are selective for I sub(Gly), because GABA-activated current in VTA neurons or in X. laevis oocytes expressing alpha 2 beta 3 gamma 2 GABA sub(A) receptor subunits were unaffected by these compounds. The maximal potentiation by THC and AEA was observed at the lowest concentration of glycine; with increasing concentrations of glycine, the potentiation significantly decreased. The site for THC and AEA seems to be distinct from that of the alcohol and volatile anesthetics. The results indicate that THC and AEA, in pharmacologically relevant concentrations, directly potentiate the function of GlyRs through an allosteric mechanism. JF - Molecular Pharmacology AU - Hejazi, Nadia AU - Zhou, Chunyi AU - Oz, Murat AU - Sun, Hui AU - Ye, Jiang Hong AU - Zhang, Li AD - Laboratory of Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland (N.H., H.S., L.Z.) Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 991 EP - 997 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 69 IS - 3 SN - 0026-895X, 0026-895X KW - African clawed frog KW - Toxicology Abstracts KW - Anandamide KW - Glycine receptors KW - Anesthetics KW - Ventral tegmentum KW - Tetrahydrocannabinol KW - Xenopus laevis KW - Volatiles KW - Neurons KW - Allosteric properties KW - gamma -Aminobutyric acid A receptors KW - alcohols KW - Oocytes KW - Cannabinoid CB1 receptors KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17086411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Delta+super%289%29-Tetrahydrocannabinol+and+Endogenous+Cannabinoid+Anandamide+Directly+Potentiate+the+Function+of+Glycine+Receptors&rft.au=Hejazi%2C+Nadia%3BZhou%2C+Chunyi%3BOz%2C+Murat%3BSun%2C+Hui%3BYe%2C+Jiang+Hong%3BZhang%2C+Li&rft.aulast=Hejazi&rft.aufirst=Nadia&rft.date=2006-03-01&rft.volume=69&rft.issue=3&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Tetrahydrocannabinol; Anandamide; Volatiles; Allosteric properties; Neurons; gamma -Aminobutyric acid A receptors; alcohols; Glycine receptors; Ventral tegmentum; Anesthetics; Oocytes; Cannabinoid CB1 receptors; Xenopus laevis ER - TY - JOUR T1 - Pertussis toxin as an adjuvant suppresses the number and function of CD4 super(+)CD25 super(+) T regulatory cells AN - 17082458; 6707379 AB - We observed a remarkable reduction in the frequency and immunosuppressive activity of splenic CD4 super(+)CD25 super(+) T cells in C57BL/6 mice with MOG sub(33-55)- induced experimental autoimmune encephalomyelitis (EAE). Our study revealed that pertussis toxin (PTx), one component of the immunogen used to induce murine EAE, was responsible for down-regulating splenic CD4 super(+)CD25 super(+) cells. Treatment of normal BALB/c mice with PTx in vivo reduced the frequency, suppressive activity and FoxP3 expression by splenic CD4 super(+)CD25 super(+) T cells. However, PTx treatment did not alter the expression of characteristic phenotypic markers (CD45RB, CD103, GITR and CTLA-4) and did not increase the expression of CD44 and CD69 by the residual splenic and lymph node CD4 super(+)CD25 super(+) T cells. This property of PTx was attributable to its ADP-ribosyltransferase activity. PTx did not inhibit suppressive activity of purified CD4 super(+)CD25 super(+) T regulatory (Treg) cells in vitro, but did so in vivo, presumably due to an indirect effect. Although the exact molecular target of PTx that reduces Treg activity remains to be defined, our data suggests that alteration of both distribution and function of splenic immunocytes should play a role. This study concludes that an underlying cause for the immunological adjuvanticity of PTx is down- regulation of Treg cell number and function. JF - European Journal of Immunology AU - Chen, Xin AU - Winkler-Pickett, Robin T AU - Carbonetti, Nicholas H AU - Ortaldo, John R AU - Oppenheim, Joost J AU - Howard, OMZack AD - Basic Research Program, SAIC-Frederick, Inc., Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick. Frederick, MD, USA, xinc@mail.ncifcrf.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 671 EP - 680 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 36 IS - 3 SN - 0014-2980, 0014-2980 KW - Toxicology Abstracts; Immunology Abstracts KW - CD4 super(+)CD25 super(+) T regulatory cells Experimental autoimmune encephalomyelitis Pertussis toxin KW - CD69 antigen KW - Immunoregulation KW - CD45RB antigen KW - Data processing KW - Cell number KW - CTLA-4 protein KW - NAD(P) super(+)-arginine ADP-ribosyltransferase KW - CD44 antigen KW - Spleen KW - Adjuvants KW - CD25 antigen KW - Immunosuppressive agents KW - Lymph nodes KW - pertussis toxin KW - Bordetella pertussis KW - Adjuvanticity KW - CD103 antigen KW - CD4 antigen KW - Foxp3 protein KW - Lymphocytes T KW - Experimental allergic encephalomyelitis KW - X 24310:Pharmaceuticals KW - F 06324:Multiple Sclerosis: Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17082458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=Pertussis+toxin+as+an+adjuvant+suppresses+the+number+and+function+of+CD4+super%28%2B%29CD25+super%28%2B%29+T+regulatory+cells&rft.au=Chen%2C+Xin%3BWinkler-Pickett%2C+Robin+T%3BCarbonetti%2C+Nicholas+H%3BOrtaldo%2C+John+R%3BOppenheim%2C+Joost+J%3BHoward%2C+OMZack&rft.aulast=Chen&rft.aufirst=Xin&rft.date=2006-03-01&rft.volume=36&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200535353 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - CD69 antigen; Immunoregulation; CD45RB antigen; Data processing; Cell number; NAD(P) super(+)-arginine ADP-ribosyltransferase; CTLA-4 protein; CD44 antigen; Spleen; Adjuvants; CD25 antigen; Immunosuppressive agents; Lymph nodes; pertussis toxin; CD4 antigen; CD103 antigen; Adjuvanticity; Foxp3 protein; Lymphocytes T; Experimental allergic encephalomyelitis; Bordetella pertussis DO - http://dx.doi.org/10.1002/eji.200535353 ER - TY - JOUR T1 - Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: a multisite effectiveness study. AN - 70730545; 16169159 AB - Despite recent emphasis on integrating empirically validated treatment into clinical practice, there are little data on whether manual-guided behavioral therapies can be implemented in standard clinical practice and whether incorporation of such techniques is associated with improved outcomes. The effectiveness of integrating motivational interviewing (MI) techniques into the initial contact and evaluation session was evaluated in a multisite randomized clinical trial. Participants were 423 substance users entering outpatient treatment in five community-based treatment settings, who were randomized to receive either the standard intake/evaluation session at each site or the same session in which MI techniques and strategies were integrated. Clinicians were drawn from the staff of the participating programs and were randomized either to learn and implement MI or to deliver the standard intake/evaluation session. Independent analyses of 315 session audiotapes suggested the two forms of treatment were highly discriminable and that clinicians trained to implement MI tended to have higher skill ratings. Regarding outcomes, for the sample as a whole, participants assigned to MI had significantly better retention through the 28-day follow-up than those assigned to the standard intervention. There were no significant effects of MI on substance use outcomes at either the 28-day or 84-day follow-up. Results suggest that community-based clinicians can effectively implement MI when provided training and supervision, and that integrating MI techniques in the earliest phases of treatment may have positive effects on retention early in the course of treatment. JF - Drug and alcohol dependence AU - Carroll, Kathleen M AU - Ball, Samuel A AU - Nich, Charla AU - Martino, Steve AU - Frankforter, Tami L AU - Farentinos, Christiane AU - Kunkel, Lynn E AU - Mikulich-Gilbertson, Susan K AU - Morgenstern, Jon AU - Obert, Jeanne L AU - Polcin, Doug AU - Snead, Ned AU - Woody, George E AU - National Institute on Drug Abuse Clinical Trials Network AD - Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA. kathleen.carroll@yale.edu ; National Institute on Drug Abuse Clinical Trials Network Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 SP - 301 EP - 312 VL - 81 IS - 3 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Female KW - Patient Compliance -- statistics & numerical data KW - Interview, Psychological KW - Motivation KW - Patient Acceptance of Health Care KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70730545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Motivational+interviewing+to+improve+treatment+engagement+and+outcome+in+individuals+seeking+treatment+for+substance+abuse%3A+a+multisite+effectiveness+study.&rft.au=Carroll%2C+Kathleen+M%3BBall%2C+Samuel+A%3BNich%2C+Charla%3BMartino%2C+Steve%3BFrankforter%2C+Tami+L%3BFarentinos%2C+Christiane%3BKunkel%2C+Lynn+E%3BMikulich-Gilbertson%2C+Susan+K%3BMorgenstern%2C+Jon%3BObert%2C+Jeanne+L%3BPolcin%2C+Doug%3BSnead%2C+Ned%3BWoody%2C+George+E%3BNational+Institute+on+Drug+Abuse+Clinical+Trials+Network&rft.aulast=Carroll&rft.aufirst=Kathleen&rft.date=2006-02-28&rft.volume=81&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2003 Oct;71(5):843-61 [14516234] Addiction. 2004 Jan;99(1):39-52 [14678061] J Subst Abuse Treat. 2003 Sep;25(2):117-21 [14680015] Drug Alcohol Depend. 2004 Jan 7;73(1):99-106 [14687964] J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] AIDS. 1991 Feb;5(2):181-5 [2031690] J Subst Abuse. 1990;2(2):217-35 [2136111] Br J Addict. 1992 Jul;87(7):1013-24 [1322747] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] Drug Alcohol Depend. 1994 Feb;34(3):201-9 [8033757] Drug Alcohol Depend. 1994 Apr;35(2):127-32 [8055734] J Consult Clin Psychol. 1994 Aug;62(4):843-50 [7962889] J Stud Alcohol Suppl. 1994 Dec;12:112-8 [7722987] J Stud Alcohol Suppl. 1994 Dec;12:70-5 [7723001] J Stud Alcohol. 1997 Jan;58(1):7-29 [8979210] J Clin Psychol. 1998 Apr;54(3):297-301 [9545167] J Stud Alcohol. 2000 Jan;61(1):55-63 [10627097] Drug Alcohol Depend. 2000 Jan 1;57(3):225-38 [10661673] J Consult Clin Psychol. 2000 Feb;68(1):134-44 [10710848] Psychol Addict Behav. 2001 Jun;15(2):159-62 [11419233] Addiction. 2001 Aug;96(8):1149-60 [11487421] J Consult Clin Psychol. 2001 Dec;69(6):1007-17 [11777104] Addiction. 2001 Dec;96(12):1725-42 [11784466] Addiction. 2002 Mar;97(3):265-77 [11964100] J Subst Abuse Treat. 2002 Sep;23(2):73-80 [12220604] J Subst Abuse Treat. 2002 Dec;23(4):309-18 [12495792] Psychiatr Serv. 2003 Mar;54(3):333-9 [12610240] Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] J Consult Clin Psychol. 2003 Aug;71(4):754-63 [12924680] J Consult Clin Psychol. 1998 Apr;66(2):290-303 [9583332] Drug Alcohol Depend. 1998 Aug 1;51(3):253-63; discussion 267-8 [9787998] J Consult Clin Psychol. 1999 Feb;67(1):37-42 [10028207] J Consult Clin Psychol. 2004 Dec;72(6):1050-62 [15612851] Psychol Bull. 1979 Mar;86(2):420-8 [18839484] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. AN - 67724611; 16520553 AB - Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and apigenin suppressed PMA-induced PLD activation in a dose-dependent manner as well as basal PLD activity, suggesting the involvement of CKII in the activation of both PLD1 and PLD2. CKII was associated with PLD1 and PLD2 in co-transfection experiments. Furthermore, CKII induced serine/threonine phosphorylation of PLD2 in vivo, and the multiple regions of PLD2 were phosphorylated by CKII in vitro kinase assay using glutathione S-transferase-PLD2 fusion protein fragments. Elevated expression of CKII or PLD increased cell proliferation but pretreatment of cells with 1-butanol suppressed CKII-induced cell proliferation. These results suggest that CKII is involved in proliferation of U87 cells at least in part, through stimulation of PLD activity. JF - Experimental & molecular medicine AU - Ahn, Bong-Hyun AU - Min, Gyesik AU - Bae, Yoe-Sik AU - Bae, Young-Seuk AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute (NHLBI), NIH Bldg 10/CRC 5-3288, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 SP - 55 EP - 62 VL - 38 IS - 1 SN - 1226-3613, 1226-3613 KW - Enzyme Inhibitors KW - 0 KW - Recombinant Fusion Proteins KW - 1-Butanol KW - 8PJ61P6TS3 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Casein Kinase II KW - EC 2.7.11.1 KW - Phospholipase D KW - EC 3.1.4.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - 1-Butanol -- pharmacology KW - Cell Proliferation -- drug effects KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Humans KW - Glutathione Transferase -- metabolism KW - Cell Line, Tumor KW - Precipitin Tests KW - Phosphorylation -- drug effects KW - Recombinant Fusion Proteins -- metabolism KW - Blotting, Western KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Phospholipase D -- metabolism KW - Casein Kinase II -- analysis KW - Astrocytoma -- enzymology KW - Phospholipase D -- genetics KW - Casein Kinase II -- pharmacology KW - Astrocytoma -- pathology KW - Astrocytoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67724611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+%26+molecular+medicine&rft.atitle=Phospholipase+D+is+activated+and+phosphorylated+by+casein+kinase-II+in+human+U87+astroglioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BMin%2C+Gyesik%3BBae%2C+Yoe-Sik%3BBae%2C+Young-Seuk%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2006-02-28&rft.volume=38&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Experimental+%26+molecular+medicine&rft.issn=12263613&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Structures of the Essential Mosquito-Stage Protein P25 and its Complex with a Transmission-Blocking Antibody T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39942297; 4143219 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Garboczi, David Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Antibodies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Structures+of+the+Essential+Mosquito-Stage+Protein+P25+and+its+Complex+with+a+Transmission-Blocking+Antibody&rft.au=Garboczi%2C+David&rft.aulast=Garboczi&rft.aufirst=David&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population Structure and Evolution in P. falciparum T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39933528; 4143224 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Su, Xin-Zhuan Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Population structure KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Population+Structure+and+Evolution+in+P.+falciparum&rft.au=Su%2C+Xin-Zhuan&rft.aulast=Su&rft.aufirst=Xin-Zhuan&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Responses to Malaria Vaccine Candidates T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39892884; 4143232 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Long, Carole A Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Vaccines KW - Malaria KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Immune+Responses+to+Malaria+Vaccine+Candidates&rft.au=Long%2C+Carole+A&rft.aulast=Long&rft.aufirst=Carole&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combinatorial Vaccine Strategies T2 - 2006 Conference of the Sidney Kimmel Cancer Center AN - 39930509; 4161750 JF - 2006 Conference of the Sidney Kimmel Cancer Center AU - Schlom, Jeffrey Y1 - 2006/02/27/ PY - 2006 DA - 2006 Feb 27 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Sidney+Kimmel+Cancer+Center&rft.atitle=Combinatorial+Vaccine+Strategies&rft.au=Schlom%2C+Jeffrey&rft.aulast=Schlom&rft.aufirst=Jeffrey&rft.date=2006-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Sidney+Kimmel+Cancer+Center&rft.issn=&rft_id=info:doi/ L2 - http://skcc.org/SKCC_conf_program_06.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ebola Virus Immunity T2 - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AN - 40140288; 4099028 JF - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AU - Sullivan, Nancy J Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Immunity KW - Ebola virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40140288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.atitle=Ebola+Virus+Immunity&rft.au=Sullivan%2C+Nancy+J&rft.aulast=Sullivan&rft.aufirst=Nancy&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins T2 - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AN - 40116965; 4098995 JF - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AU - Blumenthal, Robert P Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Glycoproteins KW - Envelopes KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.atitle=Conformational+Changes+and+Fusion+Activity+of+HIV+Envelope+Glycoproteins&rft.au=Blumenthal%2C+Robert+P&rft.aulast=Blumenthal&rft.aufirst=Robert&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ty1 Suicide: Formation of LTR Joint Molecules and Autointegration T2 - 2006 Conference of the American Society for Microbiology on Mobile DNA AN - 39979561; 4159276 JF - 2006 Conference of the American Society for Microbiology on Mobile DNA AU - Garfinkel, David J Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Suicide KW - Joints UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39979561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.atitle=Ty1+Suicide%3A+Formation+of+LTR+Joint+Molecules+and+Autointegration&rft.au=Garfinkel%2C+David+J&rft.aulast=Garfinkel&rft.aufirst=David&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.issn=&rft_id=info:doi/ L2 - http://www.asm.org/Meetings/index.asp?bid=37149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The LTR-Retrotransposon Tf1 Integrates Specifically into the Promoters of Pol II Transcribed Genes T2 - 2006 Conference of the American Society for Microbiology on Mobile DNA AN - 39878787; 4159289 JF - 2006 Conference of the American Society for Microbiology on Mobile DNA AU - Levin, Henry Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Promoters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.atitle=The+LTR-Retrotransposon+Tf1+Integrates+Specifically+into+the+Promoters+of+Pol+II+Transcribed+Genes&rft.au=Levin%2C+Henry&rft.aulast=Levin&rft.aufirst=Henry&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.issn=&rft_id=info:doi/ L2 - http://www.asm.org/Meetings/index.asp?bid=37149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis. AN - 67685651; 16205634 AB - The CCAAT/enhancer binding protein beta (C/EBP beta) is implicated in the regulation of many different molecular and physiological processes. Mice with a germline deletion of C/EBP beta (C/EBP beta(-/-)) display phenotypes in a multitude of cell types and organ systems, including skin where C/EBP beta(-/-) mice exhibit increased apoptosis in epidermal keratinocytes in response to carcinogen treatment and are completely resistant to carcinogen-induced skin tumorigenesis. To determine the contribution of systemic versus cell autonomous functions of C/EBP beta to specific phenotypes, mice with a conditional 'floxed' C/EBP beta null allele were generated. Epidermal-specific deletion of C/EBP beta was achieved by Cre recombinase expression from a keratin 5 (K5) promoter. Similar to C/EBP beta(-/-) mice, K5-Cre;C/EBP beta(fl/fl) mice were completely refractory to 7,12 dimethylbenz[a]anthracene (DMBA)-induced skin tumorigenesis and these mice displayed increased DMBA-induced apoptosis in epidermal keratinocytes compared to wild-type mice. In contrast, mice lacking the related gene, C/EBP delta, were not resistant to DMBA-induced skin tumorigenesis, indicating a unique role of C/EBP beta in skin tumor development. Our findings demonstrate that C/EBP beta exerts an essential, keratinocyte-intrinsic role in cell survival in response to carcinogen treatment and the elimination of C/EBP beta in keratinocytes is sufficient to confer complete resistance of the skin to chemical carcinogenesis. Oncogene (2006) 25, 1272-1276. doi:10.1038/sj.onc.1209144; published online 3 October 2005. JF - Oncogene AU - Sterneck, E AU - Zhu, S AU - Ramirez, A AU - Jorcano, J L AU - Smart, R C AD - Molecular Mechanisms in Development Group, Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD , USA. Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 SP - 1272 EP - 1276 VL - 25 IS - 8 SN - 0950-9232, 0950-9232 KW - CCAAT-Enhancer-Binding Protein-beta KW - 0 KW - Carcinogens KW - Keratin-15 KW - Keratin-5 KW - Krt1-15 protein, mouse KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Keratins KW - 68238-35-7 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Keratins -- genetics KW - Tetradecanoylphorbol Acetate -- toxicity KW - Animals KW - Carcinogens -- toxicity KW - Mice KW - Mice, Knockout KW - Integrases -- metabolism KW - Promoter Regions, Genetic KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mice, Inbred C57BL KW - Female KW - Apoptosis KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- pathology KW - CCAAT-Enhancer-Binding Protein-beta -- physiology KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Skin Neoplasms -- metabolism KW - CCAAT-Enhancer-Binding Protein-beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Conditional+ablation+of+C%2FEBP+beta+demonstrates+its+keratinocyte-specific+requirement+for+cell+survival+and+mouse+skin+tumorigenesis.&rft.au=Sterneck%2C+E%3BZhu%2C+S%3BRamirez%2C+A%3BJorcano%2C+J+L%3BSmart%2C+R+C&rft.aulast=Sterneck&rft.aufirst=E&rft.date=2006-02-23&rft.volume=25&rft.issue=8&rft.spage=1272&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2003 Feb;23(3):1044-53 [12529408] Toxicol Sci. 2002 Sep;69(1):42-8 [12215659] Carcinogenesis. 2003 May;24(5):817-26 [12771024] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6546-51 [12732721] Cell. 2003 Aug 8;114(3):323-34 [12914697] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Oncogene. 2004 Feb 26;23(8):1549-57 [14716301] Mol Cell Biol. 2004 Apr;24(8):3238-50 [15060147] Genesis. 2004 May;39(1):52-7 [15124227] Mol Cell Biol. 2004 Sep;24(17):7380-91 [15314150] Cancer Res. 1983 May;43(5 Suppl):2465s-2468s [6339050] Cell. 1995 Jan 27;80(2):353-61 [7530603] EMBO J. 1995 May 1;14(9):1932-41 [7744000] J Exp Med. 1996 Oct 1;184(4):1561-6 [8879230] Genes Dev. 1997 Sep 1;11(17):2153-62 [9303532] J Invest Dermatol. 1998 Jun;110(6):939-45 [9620302] Genes Dev. 1998 Jun 15;12(12):1907-16 [9637691] J Biol Chem. 1998 Oct 16;273(42):27686-94 [9765305] J Biol Chem. 1998 Nov 6;273(45):29279-82 [9792624] Br J Cancer. 1999 Mar;79(7-8):1240-8 [10098766] Mol Cell Biol. 1999 Oct;19(10):7181-90 [10490653] Cancer Cell. 2004 Nov;6(5):447-58 [15542429] Cancer Res. 2005 Feb 1;65(3):861-7 [15705884] Cancer Res. 2005 Apr 1;65(7):2592-601 [15805255] J Cell Sci. 2005 Jun 15;118(Pt 12):2545-55 [15944395] Int J Cancer. 2000 May 1;86(3):337-43 [10760820] Methods Mol Biol. 2001;158:47-63 [11236671] Nat Rev Genet. 2001 Oct;2(10):743-55 [11584291] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):207-12 [11756662] Biochem J. 2002 Aug 1;365(Pt 3):561-75 [12006103] Oncogene. 2003 Feb 13;22(6):869-83 [12584567] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Immune Aspects of Type 1 Diabetes and Islet Transplantation T2 - 2006 Keystone Symposia on Towards Understanding Islet Biology (X1) AN - 40096403; 4098926 JF - 2006 Keystone Symposia on Towards Understanding Islet Biology (X1) AU - Harlan, David M Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 KW - Transplantation KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40096403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Towards+Understanding+Islet+Biology+%28X1%29&rft.atitle=Immune+Aspects+of+Type+1+Diabetes+and+Islet+Transplantation&rft.au=Harlan%2C+David+M&rft.aulast=Harlan&rft.aufirst=David&rft.date=2006-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Towards+Understanding+Islet+Biology+%28X1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=779 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Islet Precursors from Mature Islet Cells T2 - 2006 Keystone Symposia on Pancreatic Islets: From Development to Transplantation (X2) AN - 39899146; 4143380 JF - 2006 Keystone Symposia on Pancreatic Islets: From Development to Transplantation (X2) AU - Gershengorn, Marvin C Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 KW - Islets of Langerhans KW - Islet cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Pancreatic+Islets%3A+From+Development+to+Transplantation+%28X2%29&rft.atitle=Human+Islet+Precursors+from+Mature+Islet+Cells&rft.au=Gershengorn%2C+Marvin+C&rft.aulast=Gershengorn&rft.aufirst=Marvin&rft.date=2006-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Pancreatic+Islets%3A+From+Development+to+Transplantation+%28X2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=778 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI Research Training and Early Career Development Opportunities T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40143119; 4098813 JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Skarlatos, Sonia I Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Training KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40143119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=NHLBI+Research+Training+and+Early+Career+Development+Opportunities&rft.au=Skarlatos%2C+Sonia+I&rft.aulast=Skarlatos&rft.aufirst=Sonia&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vascular Proliferation and Inflammation: Lessons Learned from Genetic Diseases T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40140004; 4098814 JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Nabel, Elizabeth G Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Vascular system KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40140004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=Vascular+Proliferation+and+Inflammation%3A+Lessons+Learned+from+Genetic+Diseases&rft.au=Nabel%2C+Elizabeth+G&rft.aulast=Nabel&rft.aufirst=Elizabeth&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI and NIH Programs in Cell-Based Therapeutics T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40121913; 4098812 DE: JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Mockrin, Stephen C Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=NHLBI+and+NIH+Programs+in+Cell-Based+Therapeutics&rft.au=Mockrin%2C+Stephen+C&rft.aulast=Mockrin&rft.aufirst=Stephen&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fostering the Independence of New Investigators: NHLBI initiatives T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40095988; 4098811 DE: JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Nabel, Elizabeth G Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=Fostering+the+Independence+of+New+Investigators%3A+NHLBI+initiatives&rft.au=Nabel%2C+Elizabeth+G&rft.aulast=Nabel&rft.aufirst=Elizabeth&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association of Vision Science Librarians: Providing Information and Information Resources for Vision Care, Research and Education Worldwide T2 - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AN - 39852124; 4169796 JF - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AU - Sieving, Pamela C AU - Young, Judith Schaeffer Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Vision KW - Education KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.atitle=The+Association+of+Vision+Science+Librarians%3A+Providing+Information+and+Information+Resources+for+Vision+Care%2C+Research+and+Education+Worldwide&rft.au=Sieving%2C+Pamela+C%3BYoung%2C+Judith+Schaeffer&rft.aulast=Sieving&rft.aufirst=Pamela&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingeventos.com.br/site/inicio.asp?action=CTL&congresso= woctl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Adamantiades-Behcets Disease-A Trend in Time T2 - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AN - 39849960; 4171257 JF - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AU - Kump, Leila I AU - Moeller, Kristy L AU - Kurup, Shree K AU - Reed, George F AU - Levy-Clarke, Grace AU - Nussenblatt, Robert B Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Acquired immune deficiency syndrome KW - Uveitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.atitle=Ocular+Adamantiades-Behcets+Disease-A+Trend+in+Time&rft.au=Kump%2C+Leila+I%3BMoeller%2C+Kristy+L%3BKurup%2C+Shree+K%3BReed%2C+George+F%3BLevy-Clarke%2C+Grace%3BNussenblatt%2C+Robert+B&rft.aulast=Kump&rft.aufirst=Leila&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingeventos.com.br/site/inicio.asp?action=CTL&congresso= woctl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Refolding of HIV-1 Gp41 in the Course of Gp41-Mediated Membrane Fusion. T2 - 50th Annual Meeting of the Biophysical Society AN - 39863940; 4084017 JF - 50th Annual Meeting of the Biophysical Society AU - Blumenthal, Robert P Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Membrane fusion KW - Glycoprotein gp41 KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Refolding+of+HIV-1+Gp41+in+the+Course+of+Gp41-Mediated+Membrane+Fusion.&rft.au=Blumenthal%2C+Robert+P&rft.aulast=Blumenthal&rft.aufirst=Robert&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From Antibodies to the Innate Immune System T2 - 50th Annual Meeting of the Biophysical Society AN - 39822550; 4083955 JF - 50th Annual Meeting of the Biophysical Society AU - Davies, David R Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Immune system KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39822550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=From+Antibodies+to+the+Innate+Immune+System&rft.au=Davies%2C+David+R&rft.aulast=Davies&rft.aufirst=David&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Watching Proteins Function with Picosecond Time-Resolved X-Ray Crystallography T2 - 50th Annual Meeting of the Biophysical Society AN - 39811865; 4084027 JF - 50th Annual Meeting of the Biophysical Society AU - Anfinrud, Philip A Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - X-ray crystallography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Watching+Proteins+Function+with+Picosecond+Time-Resolved+X-Ray+Crystallography&rft.au=Anfinrud%2C+Philip+A&rft.aulast=Anfinrud&rft.aufirst=Philip&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast Kinetics and Mechanisms in Protein Folding T2 - 50th Annual Meeting of the Biophysical Society AN - 39811662; 4083992 JF - 50th Annual Meeting of the Biophysical Society AU - Eaton, William A Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Kinetics KW - Protein folding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Fast+Kinetics+and+Mechanisms+in+Protein+Folding&rft.au=Eaton%2C+William+A&rft.aulast=Eaton&rft.aufirst=William&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanostructures Design with Protein Building Blocks T2 - 50th Annual Meeting of the Biophysical Society AN - 39708355; 4083974 JF - 50th Annual Meeting of the Biophysical Society AU - Nussinov, Ruth Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nanostructures+Design+with+Protein+Building+Blocks&rft.au=Nussinov%2C+Ruth&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A new peptide input to learning and addiction. AN - 67657603; 16476658 AB - In this issue of Neuron, Borgland et al. report that the arousal-associated peptide orexin enhances LTP-like changes in glutamatergic excitability of ventral tegmental dopamine neurons. This parallels a similar effect of corticotropin-releasing factor and suggests a form of neuroadaptation that increases the likelihood of addiction relapse. JF - Neuron AU - Wise, Roy A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2006/02/16/ PY - 2006 DA - 2006 Feb 16 SP - 483 EP - 484 VL - 49 IS - 4 SN - 0896-6273, 0896-6273 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Neuropeptides KW - Orexins KW - Index Medicus KW - Rats KW - Animals KW - Ventral Tegmental Area -- drug effects KW - Ventral Tegmental Area -- physiology KW - Neuropeptides -- physiology KW - Learning -- physiology KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=A+new+peptide+input+to+learning+and+addiction.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2006-02-16&rft.volume=49&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Neuron. 2006 Feb 16;49(4):589-601 [16476667] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells. AN - 70719242; 16152591 AB - Vascular endothelial growth factor-D (VEGF-D) stimulates growth of vascular and lymphatic endothelial cells by signaling through the tyrosine kinase receptors KDR (VEGFR-2) and Flt-4 (VEGFR-3). In the present study, we examined the effects of VEGF-D on apoptosis in human MCF-7 and MDA-MB-231 breast carcinoma cells. Because VEGF-D was not expressed constitutively in vitro, stable VEGF-D transfectants were produced. The VEGF-D-expressing MCF-7 and MDA-MB-231 lines displayed resistance to apoptosis induced by hypoxia, staurosporin and cycloheximide. Increased Bcl-2 expression, decreased homogenous caspase activities and inhibition of poly(ADP-ribose) polymerase cleavage were associated with inhibition of apoptosis in VEGF-D-expressing clones. Also, caspase-3 activation was suppressed in the VEGF-D expressing MDA-MB-231 clone. The antiapoptotic effect of VEGF-D in vitro was recapitulated in vivo using VEGF-D-expressing MDA-MB-231 xenografts. The lack of VEGFR-2 protein expression by Western blot and ineffectiveness of a neutralizing VEGFR-2 antibody in eliminating the antiapoptotic effects of VEGF-D suggest a different and yet unknown signaling mechanism. Our findings indicate that VEGF-D has a novel function as a survival factor of breast carcinoma cells in addition to its established functions as an angiogenic and lymphangiogenic factor. JF - International journal of cancer AU - Akahane, Manabu AU - Akahane, Takemi AU - Matheny, Shannon L AU - Shah, Amy AU - Okajima, Eijiro AU - Thorgeirsson, Unnur P AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 841 EP - 849 VL - 118 IS - 4 SN - 0020-7136, 0020-7136 KW - Vascular Endothelial Growth Factor D KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Transfection KW - Humans KW - Antibody Formation KW - Neovascularization, Pathologic KW - Cell Hypoxia KW - Signal Transduction KW - Female KW - Vascular Endothelial Growth Factor D -- physiology KW - Apoptosis KW - Breast Neoplasms -- pathology KW - Vascular Endothelial Growth Factor D -- biosynthesis KW - Cell Survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Vascular+endothelial+growth+factor-D+is+a+survival+factor+for+human+breast+carcinoma+cells.&rft.au=Akahane%2C+Manabu%3BAkahane%2C+Takemi%3BMatheny%2C+Shannon+L%3BShah%2C+Amy%3BOkajima%2C+Eijiro%3BThorgeirsson%2C+Unnur+P&rft.aulast=Akahane&rft.aufirst=Manabu&rft.date=2006-02-15&rft.volume=118&rft.issue=4&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. AN - 70717682; 16262601 AB - Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a profound inflammatory syndrome with erosive arthritis, autoimmunity and myeloid hyperplasia. Previous studies showed that TTP is phosphorylated extensively in intact cells. However, limited information is available about the identities of these phosphorylation sites. We investigated the phosphorylation sites in human TTP from transfected HEK-293 cells by MS and site-directed mutagenesis. A number of phosphorylation sites including Ser66, Ser88, Thr92, Ser169, Ser186, Ser197, Ser218, Ser228, Ser276 and Ser296 were identified by MS analyses using MALDI (matrix-assisted laser-desorption-ionization)-MS, MALDI-tandem MS, LC (liquid chromatography)-tandem MS and multidimensional protein identification technology. Mutations of Ser197, Ser218 and Ser228 to alanine in the human protein significantly increased TTP's gel mobility (likely to be stoichiometric), whereas mutations at the other sites had little effect on its gel mobility. Dephosphorylation and in vivo labelling studies showed that mutant proteins containing multiple mutations were still phosphorylated, and all were able to bind to RNA probes containing AREs. Confocal microscopy showed a similar cytosolic localization of TTP among the various proteins. Ser197, Ser218 and Ser228 are predicted by motif scanning to be potential sites for protein kinase A, glycogen synthase kinase-3 and extracellular-signal-regulated kinase 1 (both Ser218 and Ser228) respectively. The present study has identified multiple phosphorylation sites in the anti-inflammatory protein TTP in mammalian cells and should provide the molecular basis for further studies on the function and regulation of TTP in controlling pro-inflammatory cytokines. JF - The Biochemical journal AU - Cao, Heping AU - Deterding, Leesa J AU - Venable, John D AU - Kennington, Elizabeth A AU - Yates, John R AU - Tomer, Kenneth B AU - Blackshear, Perry J AD - Laboratories of Neurobiology and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. caoh@ba.ars.usda.gov Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 285 EP - 297 VL - 394 KW - Anti-Inflammatory Agents KW - 0 KW - Tristetraprolin KW - Index Medicus KW - Mass Spectrometry KW - Sequence Alignment KW - Phosphorylation KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Mutation KW - Cell Line KW - Protein Transport KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Anti-Inflammatory Agents -- metabolism KW - Anti-Inflammatory Agents -- chemistry KW - Tristetraprolin -- chemistry KW - Tristetraprolin -- metabolism KW - Tristetraprolin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70717682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Identification+of+the+anti-inflammatory+protein+tristetraprolin+as+a+hyperphosphorylated+protein+by+mass+spectrometry+and+site-directed+mutagenesis.&rft.au=Cao%2C+Heping%3BDeterding%2C+Leesa+J%3BVenable%2C+John+D%3BKennington%2C+Elizabeth+A%3BYates%2C+John+R%3BTomer%2C+Kenneth+B%3BBlackshear%2C+Perry+J&rft.aulast=Cao&rft.aufirst=Heping&rft.date=2006-02-15&rft.volume=394&rft.issue=&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-24 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 2001 Oct 1;359(Pt 1):1-16 [11563964] Mol Cell Biol. 2001 Oct;21(19):6461-9 [11533235] J Biol Chem. 2002 Mar 15;277(11):9606-13 [11782475] J Biol Chem. 2002 May 17;277(20):18029-36 [11886850] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5 [12060738] Biochem Soc Trans. 2002 Nov;30(Pt 6):945-52 [12440952] Arch Biochem Biophys. 2003 Apr 1;412(1):106-20 [12646273] Mol Cell Biol. 2003 Jun;23(11):3798-812 [12748283] Nucleic Acids Res. 2003 Jul 1;31(13):3635-41 [12824383] J Biol Chem. 2003 Oct 3;278(40):38593-600 [14514795] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2011-6 [14769925] J Biol Chem. 2004 Mar 12;279(11):10176-84 [14688255] EMBO J. 2004 Mar 24;23(6):1313-24 [15014438] J Biol Chem. 2004 May 14;279(20):21489-99 [15010466] Anal Chem. 2004 May 15;76(10):2928-37 [15144207] Proteomics. 2004 Jun;4(6):1633-49 [15174133] Mol Cell Biol. 2004 Jul;24(14):6445-55 [15226444] J Biol Chem. 2004 Aug 13;279(33):34496-504 [15194681] Development. 2004 Oct;131(19):4883-93 [15342461] Biochemistry. 2004 Nov 2;43(43):13724-38 [15504035] J Biol Chem. 1975 Oct 10;250(19):7795-801 [170270] J Biol Chem. 1979 Apr 10;254(7):2499-508 [218941] Oncogene. 1989 Jan;4(1):119-20 [2915901] J Biol Chem. 1990 Sep 25;265(27):16556-63 [2204625] J Biol Chem. 1990 Nov 5;265(31):19185-91 [1699942] J Biol Chem. 1995 Jun 2;270(22):13341-7 [7768935] Immunity. 1996 May;4(5):445-54 [8630730] Mol Endocrinol. 1996 Feb;10(2):140-6 [8825554] J Biol Chem. 1997 Jan 10;272(2):952-60 [8995387] Science. 1998 Aug 14;281(5379):1001-5 [9703499] Mol Cell Biol. 1999 Jun;19(6):4311-23 [10330172] Biol Reprod. 2005 Aug;73(2):297-307 [15814898] Blood. 2000 Mar 15;95(6):1891-9 [10706852] J Biol Chem. 2000 Apr 7;275(14):10463-71 [10744736] J Am Soc Mass Spectrom. 2000 Apr;11(4):273-82 [10757163] Arch Biochem Biophys. 2000 Oct 15;382(2):310-3 [11068883] Nat Biotechnol. 2001 Apr;19(4):348-53 [11283593] Endocr Rev. 2001 Apr;22(2):153-83 [11294822] J Biol Chem. 2001 Jun 22;276(25):23144-54 [11279239] Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508 [11435226] Mol Cell Biol. 2001 Sep;21(17):5778-89 [11486017] J Biol Chem. 2001 Nov 9;276(45):42580-7 [11546803] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. AN - 67672794; 16488997 AB - The vast majority of deaths associated with cancer are a consequence of a complex phenotypic behavior, metastasis, by which tumor cells spread from their primary site of origin to regional and distant sites. This process requires the tumor cell to make numerous adjustments, both subtle and dramatic, to successfully reach, survive, and flourish at favorable secondary sites. It has been suggested that molecular mechanisms accounting for metastatic behavior can recapitulate those employed during embryogenesis. We have shown that the homeodomain transcription factor Six1, known to be required for normal development of migratory myogenic progenitor cells, is sufficient to promote metastatic spread in a mouse model of the pediatric skeletal muscle cancer rhabdomyosarcoma. Here, we report that Six1 is able to activate the expression of a set of protumorigenic genes (encoding cyclin D1, c-Myc, and Ezrin) that can control cell proliferation, survival, and motility. Although the role of Ezrin in cytoskeletal organization and adhesion has been well studied, the means by which its expression is regulated are poorly understood. We now show that the gene encoding Ezrin is a direct transcriptional target of Six1. Moreover, Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers. Our data indicate that Ezrin represents a promising therapeutic target for patients with advanced-stage rhabdomyosarcoma and perhaps other malignancies. JF - Cancer research AU - Yu, Yanlin AU - Davicioni, Elai AU - Triche, Timothy J AU - Merlino, Glenn AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 1982 EP - 1989 VL - 66 IS - 4 SN - 0008-5472, 0008-5472 KW - Cytoskeletal Proteins KW - 0 KW - Homeodomain Proteins KW - Proto-Oncogene Proteins c-myc KW - RNA, Small Interfering KW - SIX1 protein, human KW - Six1 protein, mouse KW - ezrin KW - Cyclin D1 KW - 136601-57-5 KW - Index Medicus KW - Animals KW - Humans KW - Proto-Oncogene Proteins c-myc -- genetics KW - RNA, Small Interfering -- genetics KW - Cyclin D1 -- biosynthesis KW - Cyclin D1 -- genetics KW - Mice KW - Mice, Nude KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transcriptional Activation KW - Gene Expression Regulation, Neoplastic KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Transfection KW - Neoplasm Metastasis KW - RNA Interference KW - Male KW - Cytoskeletal Proteins -- biosynthesis KW - Rhabdomyosarcoma -- genetics KW - Homeodomain Proteins -- biosynthesis KW - Homeodomain Proteins -- genetics KW - Rhabdomyosarcoma -- pathology KW - Cytoskeletal Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67672794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+homeoprotein+six1+transcriptionally+activates+multiple+protumorigenic+genes+but+requires+ezrin+to+promote+metastasis.&rft.au=Yu%2C+Yanlin%3BDavicioni%2C+Elai%3BTriche%2C+Timothy+J%3BMerlino%2C+Glenn&rft.aulast=Yu&rft.aufirst=Yanlin&rft.date=2006-02-15&rft.volume=66&rft.issue=4&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene promoter methylation in prostate tumor-associated stromal cells. AN - 67660566; 16478744 AB - Gene expression can be silenced through the methylation of specific sites in the promoter region. This mechanism of gene silencing has an important role in the carcinogenesis of prostate and other cancers. Although tumor-associated stromal cells also exhibit changes in gene expression, promoter methylation has not been described in these cells. Tumor epithelia, tumor-associated stroma and normal epithelia, and stroma adjacent to tumor tissues were isolated from whole-mount prostatectomy specimens (two per patient) of patients (n = 5) with localized prostate cancer and from normal epithelia and stroma from benign prostate hyperplasia specimens (two per patient) from men (n = 5) without prostate cancer by using laser capture microdissection or expression microdissection. The methylation status of three genes important in prostate carcinogenesis, GSTP1, RARbeta2, and CD44, were evaluated using quantitative methylation-sensitive polymerase chain reaction. GSTP1 and RARbeta2 were methylated in the tumor epithelium of all five prostate cancer patients and in the tumor-associated stroma in four of the five patients. CD44 was methylated in the tumor epithelium from four of the five patients but not in the tumor stroma. GSTP1 and RARbeta2 were methylated in normal epithelium of two and four patients, respectively, and in normal stroma of one and two patients, respectively, that were isolated from regions adjacent to the tumors and may have resulted from a tumor-field effect; CD44 methylation was not observed in normal epithelium or stroma. In contrast, normal epithelia and stroma from benign prostate hyperplasia specimens showed no promoter methylation in GSTP1, RARbeta2, or CD44. The observation of promoter methylation in the non-neoplastic cells of the prostate tumor microenvironment may advance our understanding of prostate cancer development and progression and lead to new diagnostic and prognostic markers and therapeutic targets. JF - Journal of the National Cancer Institute AU - Hanson, Jeffrey A AU - Gillespie, John W AU - Grover, Amelia AU - Tangrea, Michael A AU - Chuaqui, Rodrigo F AU - Emmert-Buck, Michael R AU - Tangrea, Joseph A AU - Libutti, Stephen K AU - Linehan, W Marston AU - Woodson, Karen G AD - Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 255 EP - 261 VL - 98 IS - 4 KW - Antigens, CD44 KW - 0 KW - Receptors, Retinoic Acid KW - retinoic acid receptor beta KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Index Medicus KW - Microdissection KW - Epithelial Cells -- metabolism KW - Prostatectomy KW - Humans KW - Polymerase Chain Reaction -- methods KW - Aged KW - Middle Aged KW - Laser Therapy KW - Cell Line, Tumor KW - Prostate -- cytology KW - Male KW - Receptors, Retinoic Acid -- genetics KW - Prostatic Neoplasms -- metabolism KW - Glutathione S-Transferase pi -- genetics KW - Promoter Regions, Genetic KW - DNA Methylation KW - Gene Silencing KW - Prostatic Neoplasms -- surgery KW - Antigens, CD44 -- genetics KW - Prostatic Neoplasms -- genetics KW - Stromal Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67660566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Gene+promoter+methylation+in+prostate+tumor-associated+stromal+cells.&rft.au=Hanson%2C+Jeffrey+A%3BGillespie%2C+John+W%3BGrover%2C+Amelia%3BTangrea%2C+Michael+A%3BChuaqui%2C+Rodrigo+F%3BEmmert-Buck%2C+Michael+R%3BTangrea%2C+Joseph+A%3BLibutti%2C+Stephen+K%3BLinehan%2C+W+Marston%3BWoodson%2C+Karen+G&rft.aulast=Hanson&rft.aufirst=Jeffrey&rft.date=2006-02-15&rft.volume=98&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The limitations due to exposure detection limits for regression models. AN - 67634569; 16394206 AB - Biomarker use in exposure assessment is increasingly common, and consideration of related issues is of growing importance. Exposure quantification may be compromised when measurement is subject to a lower threshold. Statistical modeling of such data requires a decision regarding the handling of such readings. Various authors have considered this problem. In the context of linear regression analysis, Richardson and Ciampi (Am J Epidemiol 2003;157:355-63) proposed replacement of data below a threshold by a constant equal to the expectation for such data to yield unbiased estimates. Use of such an imputation has some limitations; distributional assumptions are required, and bias reduction in estimation of regression parameters is asymptotic, thereby presenting concerns about small studies. In this paper, the authors propose distribution-free methods for managing values below detection limits and evaluate the biases that may result when exposure measurement is constrained by a lower threshold. The authors utilize an analytical approach and a simulation study to assess the effects of the proposed replacement method on estimates. These results may inform decisions regarding analytical plans for future studies and provide a possible explanation for some amount of the discordance seen in extant literature. JF - American journal of epidemiology AU - Schisterman, Enrique F AU - Vexler, Albert AU - Whitcomb, Brian W AU - Liu, Aiyi AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rm. 7B03, Rockville, MD 20852, USA. schistee@mail.nih.gov Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 374 EP - 383 VL - 163 IS - 4 SN - 0002-9262, 0002-9262 KW - Biomarkers KW - 0 KW - Index Medicus KW - Humans KW - Monte Carlo Method KW - Decision Making KW - Statistical Distributions KW - Risk Assessment KW - Logistic Models KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Bias (Epidemiology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67634569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3At