TY - CPAPER T1 - Strategic Regulation of Excision Repair Through Structural and Chemical Biology T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40116683; 4084285 DE: JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Wilson, Samuel H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=Strategic+Regulation+of+Excision+Repair+Through+Structural+and+Chemical+Biology&rft.au=Wilson%2C+Samuel+H&rft.aulast=Wilson&rft.aufirst=Samuel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - All in the Family: the Role of the Polypeptide:GalNac Transferases in Development and Disease in the Craniofacial Complex T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40116600; 4084265 JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Tabak, Larry Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Transferases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=All+in+the+Family%3A+the+Role+of+the+Polypeptide%3AGalNac+Transferases+in+Development+and+Disease+in+the+Craniofacial+Complex&rft.au=Tabak%2C+Larry&rft.aulast=Tabak&rft.aufirst=Larry&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Studies of Post-Transcriptional Gene Regulation T2 - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AN - 40075413; 4084307 JF - 2006 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB 2006) AU - Hall, Traci M.T. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene regulation KW - Post-transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40075413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.atitle=Structural+Studies+of+Post-Transcriptional+Gene+Regulation&rft.au=Hall%2C+Traci+M.T.&rft.aulast=Hall&rft.aufirst=Traci&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asbmb.org/ASBMB/site.nsf/web/A2EAB5EAFE39C7518525707E006FC437?Op enDocument LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Fibroblast Growth Factor Receptor-1 (FGFR1) by Thyroid Hormone (T3): Identification of a Thyroid Hormone Response Element (TRE) in the Murine FGFR1 Promoter T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 40030152; 4233946 JF - 8th European Congress of Endocrinology (ECE 2006) AU - O'Shea, P J AU - Williams, G R AU - Cheng, S Y Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hormones KW - Thyroid hormones KW - Fibroblast growth factor receptor 1 KW - Regulatory sequences KW - Promoters KW - Triiodothyronine KW - Fibroblast growth factor KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40030152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Regulation+of+Fibroblast+Growth+Factor+Receptor-1+%28FGFR1%29+by+Thyroid+Hormone+%28T3%29%3A+Identification+of+a+Thyroid+Hormone+Response+Element+%28TRE%29+in+the+Murine+FGFR1+Promoter&rft.au=O%27Shea%2C+P+J%3BWilliams%2C+G+R%3BCheng%2C+S+Y&rft.aulast=O%27Shea&rft.aufirst=P&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Chemoimmunotherapy in a Pancreatic Cancer Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40019292; 4185929 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hance, Kenneth W AU - Rogers, Connie J AU - Zaharoff, David A AU - Schlom, Jeffrey AU - Greiner, John W Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pancreatic cancer KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Combination+Chemoimmunotherapy+in+a+Pancreatic+Cancer+Model&rft.au=Hance%2C+Kenneth+W%3BRogers%2C+Connie+J%3BZaharoff%2C+David+A%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Hance&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Papilloma Virus: What it is and What it Does T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40014954; 4181503 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lowy, Douglas Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Cancer KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40014954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Papilloma+Virus%3A+What+it+is+and+What+it+Does&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nm23-H1 Mediates Metastasis Suppression through the Receptors Edg2 and C-Met in MDA-MB-435 Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40013075; 4184255 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Horak, Christine E AU - Lee, Jong Heun AU - Elkahoun, Abdel AU - Palmieri, Diane AU - Halverson, Douglas O AU - Meltzer, Paul AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nm23-H1+Mediates+Metastasis+Suppression+through+the+Receptors+Edg2+and+C-Met+in+MDA-MB-435+Cells&rft.au=Horak%2C+Christine+E%3BLee%2C+Jong+Heun%3BElkahoun%2C+Abdel%3BPalmieri%2C+Diane%3BHalverson%2C+Douglas+O%3BMeltzer%2C+Paul%3BSteeg%2C+Patricia+S&rft.aulast=Horak&rft.aufirst=Christine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Fluid Concentrations of Platinum Analogs in Brain, Blood and Muscle Using Microdialysis in a Nonhuman Primate Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009878; 4186203 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jacobs, Shana S AU - McCully, Cynthia L AU - Bacher, John AU - Balis, Frank AU - Fox, Elizabeth Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Blood KW - Platinum KW - Muscles KW - Brain KW - Microdialysis KW - Analogs KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Extracellular+Fluid+Concentrations+of+Platinum+Analogs+in+Brain%2C+Blood+and+Muscle+Using+Microdialysis+in+a+Nonhuman+Primate+Model&rft.au=Jacobs%2C+Shana+S%3BMcCully%2C+Cynthia+L%3BBacher%2C+John%3BBalis%2C+Frank%3BFox%2C+Elizabeth&rft.aulast=Jacobs&rft.aufirst=Shana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association between the Anti-Inflammatory Protein CC10 and Smoking Status Among Participants in a Chemoprevention Trial T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009877; 4186207 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chen, Jiping AU - Lam, Stephen AU - Pilon, Aprile AU - Szabo, Eva Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Smoking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Association+between+the+Anti-Inflammatory+Protein+CC10+and+Smoking+Status+Among+Participants+in+a+Chemoprevention+Trial&rft.au=Chen%2C+Jiping%3BLam%2C+Stephen%3BPilon%2C+Aprile%3BSzabo%2C+Eva&rft.aulast=Chen&rft.aufirst=Jiping&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Functional Group of Thalidomide Analogues Selectively Kill Leukemic Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009505; 4184111 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ge, Yun AU - Montano, Idalia AU - Freebern, Wendy J AU - Haggerty, Cynthia M AU - Cui, Wenwu AU - Ponciano-Jackson, Damaris AU - Chandramouli, G V R AU - Lepper, Erin AU - Figg, William D AU - Jackson, Sharon H AU - Gardner, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Leukemia KW - Thalidomide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Novel+Functional+Group+of+Thalidomide+Analogues+Selectively+Kill+Leukemic+Cells&rft.au=Ge%2C+Yun%3BMontano%2C+Idalia%3BFreebern%2C+Wendy+J%3BHaggerty%2C+Cynthia+M%3BCui%2C+Wenwu%3BPonciano-Jackson%2C+Damaris%3BChandramouli%2C+G+V+R%3BLepper%2C+Erin%3BFigg%2C+William+D%3BJackson%2C+Sharon+H%3BGardner%2C+Kevin&rft.aulast=Ge&rft.aufirst=Yun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Cancer Cell Lines Resistant to Either Tamoxifen or Herceptin Exhibit Sensitivity to the Anti-IGF Receptor Antibody A12 In Vitro T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40009220; 4184478 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Best, Carolyn J.M. AU - Ludwig, Dale L AU - Steeg, Patricia S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Antibodies KW - Tumor cell lines KW - Tamoxifen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40009220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Breast+Cancer+Cell+Lines+Resistant+to+Either+Tamoxifen+or+Herceptin+Exhibit+Sensitivity+to+the+Anti-IGF+Receptor+Antibody+A12+In+Vitro&rft.au=Best%2C+Carolyn+J.M.%3BLudwig%2C+Dale+L%3BSteeg%2C+Patricia+S&rft.aulast=Best&rft.aufirst=Carolyn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Cell Spreading and Migration by Candidate Tumor Suppressor ING4 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008861; 4186945 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Shen, Jiang C AU - Kumamoto, Kensuke AU - Unoki, Motoko AU - Varticovski, Lyuba AU - Pedeux, Remy AU - Harris, Curtis C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cell migration KW - Tumor suppressor genes KW - Cell spreading KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Regulation+of+Cell+Spreading+and+Migration+by+Candidate+Tumor+Suppressor+ING4&rft.au=Shen%2C+Jiang+C%3BKumamoto%2C+Kensuke%3BUnoki%2C+Motoko%3BVarticovski%2C+Lyuba%3BPedeux%2C+Remy%3BHarris%2C+Curtis+C&rft.aulast=Shen&rft.aufirst=Jiang&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Profiling Distinguishes Astrocytomas of Different Grades and Identifies Differential Tumor Markers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40008550; 4186448 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Li, Jie AU - Weil, Robert AU - Okamoto, Hiroaki AU - Vortmeyer, Alexander AU - Lubensky, Irina AU - Park, Deric AU - Furuta, Makoto AU - Lee, Youn-Soo AU - Zeng, Weifen AU - Oldfield, Edward H AU - Zhuang, Zhengping Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor markers KW - Proteomics KW - Astrocytoma KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Profiling+Distinguishes+Astrocytomas+of+Different+Grades+and+Identifies+Differential+Tumor+Markers&rft.au=Li%2C+Jie%3BWeil%2C+Robert%3BOkamoto%2C+Hiroaki%3BVortmeyer%2C+Alexander%3BLubensky%2C+Irina%3BPark%2C+Deric%3BFuruta%2C+Makoto%3BLee%2C+Youn-Soo%3BZeng%2C+Weifen%3BOldfield%2C+Edward+H%3BZhuang%2C+Zhengping&rft.aulast=Li&rft.aufirst=Jie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Barriers to Eye Care: Results of Qualitative Research T2 - 3rd Annual International Health Conference of the Unite For Sight AN - 40004322; 4194600 JF - 3rd Annual International Health Conference of the Unite For Sight AU - Alexander, Robert Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Eye KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Barriers+to+Eye+Care%3A+Results+of+Qualitative+Research&rft.au=Alexander%2C+Robert&rft.aulast=Alexander&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.uniteforsight.org/2006_annual_conference.php#cliffocallahan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SCIMS: A New Algorithm for Associating Anticancer Drug Mechanisms with Gene Ontology Categories T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40002915; 4184991 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Eichler, Gabriel S AU - Reimers, Mark AU - Weinstein, John N Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drugs KW - Algorithms KW - Mathematical models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=SCIMS%3A+A+New+Algorithm+for+Associating+Anticancer+Drug+Mechanisms+with+Gene+Ontology+Categories&rft.au=Eichler%2C+Gabriel+S%3BReimers%2C+Mark%3BWeinstein%2C+John+N&rft.aulast=Eichler&rft.aufirst=Gabriel&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Aryl Hydrocarbon Receptor Repressor, a Candidate Tumor Suppressor Gene T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000778; 4182617 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zudaire, Enrique AU - Cuesta, Natalia AU - Murty, Vundavalli AU - Martinez, Alfredo AU - Narayan, Gopeshwar AU - Birrer, Mike AU - Kirsch, IlanR AU - Cuttitta, Frank Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hydrocarbons KW - Repressors KW - Tumor suppressor genes KW - Aryl hydrocarbon receptors KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Aryl+Hydrocarbon+Receptor+Repressor%2C+a+Candidate+Tumor+Suppressor+Gene&rft.au=Zudaire%2C+Enrique%3BCuesta%2C+Natalia%3BMurty%2C+Vundavalli%3BMartinez%2C+Alfredo%3BNarayan%2C+Gopeshwar%3BBirrer%2C+Mike%3BKirsch%2C+IlanR%3BCuttitta%2C+Frank&rft.aulast=Zudaire&rft.aufirst=Enrique&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Transmembrane Chemokine CXCL16 is Highly Expressed in Inflammation-Associated Cancers T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 40000623; 4182209 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Darash-Yahana, Merav AU - Gillespie, John W AU - Hewitt, Stephen M AU - Chen, Yun-Yun K AU - Maeda, Shin AU - Stein, Ilan AU - Peled, Amnon AU - Pikarsky, Eli AU - Karin, Michael AU - Farber, Joshua M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - CXCL16 protein KW - Chemokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Transmembrane+Chemokine+CXCL16+is+Highly+Expressed+in+Inflammation-Associated+Cancers&rft.au=Darash-Yahana%2C+Merav%3BGillespie%2C+John+W%3BHewitt%2C+Stephen+M%3BChen%2C+Yun-Yun+K%3BMaeda%2C+Shin%3BStein%2C+Ilan%3BPeled%2C+Amnon%3BPikarsky%2C+Eli%3BKarin%2C+Michael%3BFarber%2C+Joshua+M&rft.aulast=Darash-Yahana&rft.aufirst=Merav&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling Enhances TRAIL-Induced Apoptosis in Breast Cancer Cells by a PI3-Kinase Dependant but Akt Independent Mechanism T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39998655; 4182344 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rahman, Monzur AU - Bao, Jing AU - Nau, Marion M AU - Nguyen, Dao M AU - Lipkowitz, Stan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Epidermal growth factor receptors KW - Signal transduction KW - 1-Phosphatidylinositol 3-kinase KW - Apoptosis KW - AKT protein KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Inhibition+of+Epidermal+Growth+Factor+Receptor+%28EGFR%29+Signaling+Enhances+TRAIL-Induced+Apoptosis+in+Breast+Cancer+Cells+by+a+PI3-Kinase+Dependant+but+Akt+Independent+Mechanism&rft.au=Rahman%2C+Monzur%3BBao%2C+Jing%3BNau%2C+Marion+M%3BNguyen%2C+Dao+M%3BLipkowitz%2C+Stan&rft.aulast=Rahman&rft.aufirst=Monzur&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - XAF1 mRNA Expression Does not Predict Pathological Response Nor Prognosis in Advanced Bladder Cancer Patients Treated with Neoadjuvant Chemotherapy T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39987608; 4183894 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pinho, Marcos B AU - Sellos, Joao AU - Costas, Fernanda AU - Herchenhorn, Daniel AU - Peixoto, Fabio Afonso AU - Diengsm, Rodrigo AU - Small, Isabelle A AU - Xavier, Marisa AU - Cardoso, Hedilene AU - Guimaraes, Denise P AU - Ferreira, Carlos G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Chemotherapy KW - Cancer KW - Gene expression KW - Urinary bladder KW - Prognosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=XAF1+mRNA+Expression+Does+not+Predict+Pathological+Response+Nor+Prognosis+in+Advanced+Bladder+Cancer+Patients+Treated+with+Neoadjuvant+Chemotherapy&rft.au=Pinho%2C+Marcos+B%3BSellos%2C+Joao%3BCostas%2C+Fernanda%3BHerchenhorn%2C+Daniel%3BPeixoto%2C+Fabio+Afonso%3BDiengsm%2C+Rodrigo%3BSmall%2C+Isabelle+A%3BXavier%2C+Marisa%3BCardoso%2C+Hedilene%3BGuimaraes%2C+Denise+P%3BFerreira%2C+Carlos+G&rft.aulast=Pinho&rft.aufirst=Marcos&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges Associated with the Diagnosis, Differential Diagnosis and Treatment of 4 Cases of ACTH-Dependent Cushing's Syndrome due to Intermittent Hypercortisolism T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 39987301; 4233497 JF - 8th European Congress of Endocrinology (ECE 2006) AU - Lindsay, J R AU - Nieman, L K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cushing's syndrome KW - Differential diagnosis KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Challenges+Associated+with+the+Diagnosis%2C+Differential+Diagnosis+and+Treatment+of+4+Cases+of+ACTH-Dependent+Cushing%27s+Syndrome+due+to+Intermittent+Hypercortisolism&rft.au=Lindsay%2C+J+R%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression Associated with Achaete-Scute Homologue-1 (hASH1) in a Mouse Neuroendocrine Lung Cancer Model T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39985626; 4187082 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, Heungnam AU - Wang, Xiaoyang AU - Dakir, El Habib AU - Demayo, Franco AU - Linnoila, Ilona Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Gene expression KW - Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Differential+Gene+Expression+Associated+with+Achaete-Scute+Homologue-1+%28hASH1%29+in+a+Mouse+Neuroendocrine+Lung+Cancer+Model&rft.au=Kim%2C+Heungnam%3BWang%2C+Xiaoyang%3BDakir%2C+El+Habib%3BDemayo%2C+Franco%3BLinnoila%2C+Ilona&rft.aulast=Kim&rft.aufirst=Heungnam&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma and Cerobrospinal Fluid (CSF) Pharmacokinetics of the Histone Deacetylase (HDAC) Inhibitor, PXD101, in Non-Human Primates T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39982982; 4187345 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Warren, Katherine E AU - McCully, Cindy M AU - Dvinge, Henrik AU - Sehested, Maxwell AU - Tjornelund, Jette AU - Lichenstein, Henri S AU - Balis, Frank M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pharmacokinetics KW - Histone deacetylase KW - Colony-stimulating factor KW - Histones KW - Inhibitors KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39982982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=An+O-Glycosyltransferase+is+Required+during+Multiple+Stages+of+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Operative Serum Cortisol for Prediction of Long-Term Remission from Cushing's Syndrome T2 - 8th European Congress of Endocrinology (ECE 2006) AN - 39977642; 4233538 JF - 8th European Congress of Endocrinology (ECE 2006) AU - Lindsay, J R AU - Oldfield, E H AU - Nieman, L K Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cushing's syndrome KW - Remission KW - Hydrocortisone KW - Serum KW - Symptoms KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Post-Operative+Serum+Cortisol+for+Prediction+of+Long-Term+Remission+from+Cushing%27s+Syndrome&rft.au=Lindsay%2C+J+R%3BOldfield%2C+E+H%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0011/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Therapy of a Murine Model of Anaplastic Large Cell Lymphoma with an Anti-CD30 Monoclonal Antibody, HeFi-1, Armed with the Alpha Emitter, @@u211@At T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39977318; 4186205 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Zhang, Meili AU - Yao, Zhengsheng AU - Patel, Hiral AU - Zhang, Zhuo AU - Garmestani, Kayhan AU - Talanov, Vladimir S AU - Plascjak, Paul S AU - Goldman, Carolyn K AU - Brechbiel, Martin W AU - Waldmann, Thomas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lymphoma KW - Monoclonal antibodies KW - Animal models KW - Anaplastic large-cell lymphoma KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Drosophila+Homologue+of+the+Human+Tumor+Suppressor+Gene+BHD+Regulates+Male+Germline+Stem+Cell+Maintenance+and+Functions+Downstream+of+Dpp&rft.au=Singh%2C+Shree+R%3BZen%2C+Wei%3BZheng%2C+Zhiyu%3BWang%2C+Hong%3BOh%2C+Su-Wan%3BLiu%2C+Wei%3BZbar%2C+Berton%3BSchmidt%2C+Laura+S%3BHou%2C+Steven+X&rft.aulast=Singh&rft.aufirst=Shree&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Somatic Sequence Alterations in Genes Selected by Expression Profile Analysis of Breast Carcinomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39977148; 4186165 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chanock, Stephen AU - Burdett, Laurie AU - Yeager, Meredith AU - Llaca, Victor AU - Langerod, Anita AU - Presswalla, Shafaq AU - Kaaresen, Rolf AU - Strausberg, Robert L AU - Gerhard, Daniela S AU - Kristensen, Vessela AU - Perou, Charles M AU - Borresen-Dale, Anne-Lise Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Breast carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39977148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Somatic+Sequence+Alterations+in+Genes+Selected+by+Expression+Profile+Analysis+of+Breast+Carcinomas&rft.au=Chanock%2C+Stephen%3BBurdett%2C+Laurie%3BYeager%2C+Meredith%3BLlaca%2C+Victor%3BLangerod%2C+Anita%3BPresswalla%2C+Shafaq%3BKaaresen%2C+Rolf%3BStrausberg%2C+Robert+L%3BGerhard%2C+Daniela+S%3BKristensen%2C+Vessela%3BPerou%2C+Charles+M%3BBorresen-Dale%2C+Anne-Lise&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MRI Assessment of Nitroxide-Mediated Selective Normal Tissue Radioprotection T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39976055; 4184303 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Cotrim, Ana P AU - Hyodo, Fuminori AU - Sowers, Anastasia L AU - Matsumoto, Ken-Ichiro AU - Baum, Bruce J AU - Krishna, Murali C AU - Mitchell, James B Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Magnetic resonance imaging KW - Radioprotection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39976055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=MRI+Assessment+of+Nitroxide-Mediated+Selective+Normal+Tissue+Radioprotection&rft.au=Cotrim%2C+Ana+P%3BHyodo%2C+Fuminori%3BSowers%2C+Anastasia+L%3BMatsumoto%2C+Ken-Ichiro%3BBaum%2C+Bruce+J%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Second Cancer Incidence and Cause-Specific Mortality Following Hairy Cell Leukemia: A Population-Based Study of 3,104 Patients T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39975164; 4183768 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hisada, Michie AU - Jaffe, Elaine S AU - Travis, Lois B Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Leukemia KW - Mortality KW - Cancer KW - Hairy cell leukemia KW - Population studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39975164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Second+Cancer+Incidence+and+Cause-Specific+Mortality+Following+Hairy+Cell+Leukemia%3A+A+Population-Based+Study+of+3%2C104+Patients&rft.au=Hisada%2C+Michie%3BJaffe%2C+Elaine+S%3BTravis%2C+Lois+B&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of STAT3 Signaling in Wnt5a-Mediated Regulation of MART1 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39974844; 4186889 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dissanayake, Samudra K AU - Rosenthal, Devin T AU - Hewitt, Kyle J AU - Yang, Sherry AU - Wade, Michael AU - Taub, Dennis D AU - Nickoloff, Brian J AU - Trent, Jeffrey M AU - Bittner, Michael AU - Riker, Adam I AU - Weeraratna, Ashani T Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Signal transduction KW - Stat3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39974844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Involvement+of+STAT3+Signaling+in+Wnt5a-Mediated+Regulation+of+MART1&rft.au=Dissanayake%2C+Samudra+K%3BRosenthal%2C+Devin+T%3BHewitt%2C+Kyle+J%3BYang%2C+Sherry%3BWade%2C+Michael%3BTaub%2C+Dennis+D%3BNickoloff%2C+Brian+J%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael%3BRiker%2C+Adam+I%3BWeeraratna%2C+Ashani+T&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Hsp90 compromises the DNA Damage Response to Radiation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39974117; 4184569 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dote, Hideaki AU - Burgan, William E AU - Camphausen, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Radiation KW - DNA damage KW - Hsp90 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39974117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Inhibition+of+Hsp90+compromises+the+DNA+Damage+Response+to+Radiation&rft.au=Dote%2C+Hideaki%3BBurgan%2C+William+E%3BCamphausen%2C+Kevin&rft.aulast=Dote&rft.aufirst=Hideaki&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromogenic in Situ Hybridization (CISH) for X- And Y-Chromosomes in Sex Determination of Anatomic Pathology Specimens T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973504; 4183827 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Silva, Aloisio S AU - Palau, Mauricio AU - Merino, Maria J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Pathology KW - Sex determination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chromogenic+in+Situ+Hybridization+%28CISH%29+for+X-+And+Y-Chromosomes+in+Sex+Determination+of+Anatomic+Pathology+Specimens&rft.au=Silva%2C+Aloisio+S%3BPalau%2C+Mauricio%3BMerino%2C+Maria+J&rft.aulast=Silva&rft.aufirst=Aloisio&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Sequence Analysis of Known Cancer Genes in the NCI-60 Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39973061; 4186166 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ikediobi, Ogechi AU - Edkins, Sarah AU - Stevens, Claire AU - O'Meara, Sarah AU - Bignell, Graham AU - Teague, Jon AU - Butler, Adam AU - Buck, Gemma AU - Gray, Kristian AU - Halliday, Kelly AU - Kosmidou, Vivienne AU - Lugg, Richard AU - Menzies, Andrew AU - Perry, Janet AU - Petty, Robert AU - Raine, Keiran AU - Reinhold, William AU - Shepherd, Rebecca AU - Small, Alex AU - Widaa, Sara AU - Varian, Jennifer AU - Weinstein, John AU - Stratton, Micheal AU - Futreal, Andrew AU - Wooster, Richard Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39973061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Preliminary+Evaluation+of+Haptic+Feedback+Tools+for+CT-Guided+Robotic+Interventions.&rft.au=Viswanathan%2C+A%3BYanof%2C+J+H%3BBauer%2C+C%3BXu%2C+S.%3BKruecker%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Evidence of Synergism between DNA Damaging Agents and the HSP90 Inhibitor, 17-DMAG, in Tumors with Mutant P53 T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39972743; 4184088 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Robles, Ana I AU - Wright, Mollie H AU - Ghandi, Bheru AU - Feis, Steven AU - Harris, Curtis C AU - Varticovski, Lyuba Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mutants KW - Synergism KW - P53 protein KW - DNA damage KW - Hsp90 protein KW - Tumors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39972743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Preclinical+Evidence+of+Synergism+between+DNA+Damaging+Agents+and+the+HSP90+Inhibitor%2C+17-DMAG%2C+in+Tumors+with+Mutant+P53&rft.au=Robles%2C+Ana+I%3BWright%2C+Mollie+H%3BGhandi%2C+Bheru%3BFeis%2C+Steven%3BHarris%2C+Curtis+C%3BVarticovski%2C+Lyuba&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Gene Expression Profiling of Mucinous Ovarian Tumors and Cystadenomas Identifies Genes of Clinicopathologic Importance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39971067; 4183876 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Wamunyokoli, Fred W A AU - Bonome, Tomas AU - Lee, Ji-Young AU - Feltmate, Colleen M AU - Welch, William R AU - Radonovich, Mike AU - Pise-Masison, Cindy AU - Brady, John AU - Hao, Ke AU - Berkowitz, Ross S AU - Mok, Samuel AU - Birrer, Michael J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Global+Gene+Expression+Profiling+of+Mucinous+Ovarian+Tumors+and+Cystadenomas+Identifies+Genes+of+Clinicopathologic+Importance&rft.au=Wamunyokoli%2C+Fred+W+A%3BBonome%2C+Tomas%3BLee%2C+Ji-Young%3BFeltmate%2C+Colleen+M%3BWelch%2C+William+R%3BRadonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBrady%2C+John%3BHao%2C+Ke%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel%3BBirrer%2C+Michael+J&rft.aulast=Wamunyokoli&rft.aufirst=Fred+W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imprinted Adaptor Protein Grb10 Interacts Genetically with Nf1/p53 in Development and Tumorigenesis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39969837; 4187461 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reilly, Karlyne M AU - Tuskan, Robert AU - Kumar, Krishan AU - Stewart, Colin AU - Hagan, John AU - Fox, Kristi Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumorigenesis KW - P53 protein KW - Adaptor proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39969837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Imprinted+Adaptor+Protein+Grb10+Interacts+Genetically+with+Nf1%2Fp53+in+Development+and+Tumorigenesis&rft.au=Reilly%2C+Karlyne+M%3BTuskan%2C+Robert%3BKumar%2C+Krishan%3BStewart%2C+Colin%3BHagan%2C+John%3BFox%2C+Kristi&rft.aulast=Reilly&rft.aufirst=Karlyne&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Growth of Alveolar Soft Part Sarcoma (ASPS) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39968853; 4182169 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Vistica, David T AU - Kenney, Susan AU - Borgel, Suzanne D AU - Hollingshead, Melinda G AU - Wallqvist, Anders S AU - Covell, David G AU - Schrump, David S AU - Zhao, Ming AU - Krosky, Paula M AU - Stockwin, Luke H AU - Butcher, Donna O AU - Scudiero, Dominic A AU - Shoemaker, Robert H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Sarcoma KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39968853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Zenapax+Therapy+for+Uveitis&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging and Semiquantitation of Polycyclic Aromatic Hydrocarbon (PAH)-DNA Adducts in Human Cervix, Vulva, Placenta and Prostate Using Immunohistochemistry (IHC) and the Automated Cellular Imaging System (ACIS) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967776; 4185287 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Pratt, M Margaret AU - Sirajuddin, Paul AU - Castle, Philip E AU - Phillips, David H AU - Afework, Senait AU - MacLean, Allen B AU - Ragavan, Narasimhan AU - Martin, Francis L AU - ram, Radim J AU - Manchester, David K AU - Olivero, Ofelia A AU - Poirier, Miriam C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Polycyclic aromatic hydrocarbons KW - Imaging techniques KW - Adducts KW - Cervix KW - Immunohistochemistry KW - Prostate KW - Vulva KW - Placenta KW - Aromatic hydrocarbons KW - Automation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Imaging+and+Semiquantitation+of+Polycyclic+Aromatic+Hydrocarbon+%28PAH%29-DNA+Adducts+in+Human+Cervix%2C+Vulva%2C+Placenta+and+Prostate+Using+Immunohistochemistry+%28IHC%29+and+the+Automated+Cellular+Imaging+System+%28ACIS%29&rft.au=Pratt%2C+M+Margaret%3BSirajuddin%2C+Paul%3BCastle%2C+Philip+E%3BPhillips%2C+David+H%3BAfework%2C+Senait%3BMacLean%2C+Allen+B%3BRagavan%2C+Narasimhan%3BMartin%2C+Francis+L%3Bram%2C+Radim+J%3BManchester%2C+David+K%3BOlivero%2C+Ofelia+A%3BPoirier%2C+Miriam+C&rft.aulast=Pratt&rft.aufirst=M&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Novel Prognostic Subtype of Hepatocellular Carcinoma Derived from Hepatic Stem Cells by Comparative Functional Genomic Approach T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39967054; 4186161 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lee, Ju-Seog AU - Heo, Jeonghoon AU - Libbrecht, Louis AU - Chu, In-Sun AU - Kaposi-Novak, Pal AU - Calvisi, Diego F AU - Mikaelyan, Arsen AU - Roberts, Lewis R AU - Demetris, Anthony J AU - Sun, Zongtang AU - Nevens, Frederik AU - Roskams, Tania AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocellular carcinoma KW - Genomics KW - Stem cells KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Novel+Prognostic+Subtype+of+Hepatocellular+Carcinoma+Derived+from+Hepatic+Stem+Cells+by+Comparative+Functional+Genomic+Approach&rft.au=Lee%2C+Ju-Seog%3BHeo%2C+Jeonghoon%3BLibbrecht%2C+Louis%3BChu%2C+In-Sun%3BKaposi-Novak%2C+Pal%3BCalvisi%2C+Diego+F%3BMikaelyan%2C+Arsen%3BRoberts%2C+Lewis+R%3BDemetris%2C+Anthony+J%3BSun%2C+Zongtang%3BNevens%2C+Frederik%3BRoskams%2C+Tania%3BThorgeirsson%2C+Snorri+S&rft.aulast=Lee&rft.aufirst=Ju-Seog&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p53 Transactivation from Response Element Sequences within Cells may not Reflect In Vitro DNA Binding Ability T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39966840; 4183199 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Jordan, Jennifer J AU - Inga, Alberto AU - Darden, Thomas A AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Regulatory sequences KW - P53 protein KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39966840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=p53+Transactivation+from+Response+Element+Sequences+within+Cells+may+not+Reflect+In+Vitro+DNA+Binding+Ability&rft.au=Jordan%2C+Jennifer+J%3BInga%2C+Alberto%3BDarden%2C+Thomas+A%3BResnick%2C+Michael+A&rft.aulast=Jordan&rft.aufirst=Jennifer&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccines Containing Multiple Comstimulatory Molecules Promote the Proliferation and Activation of Human Antigen Specific Memory CD8 T Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964571; 4185921 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Sixun AU - Grosenbach, Doug AU - Schlom, Jeffrey Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Vaccines KW - Memory cells KW - Cell proliferation KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Cell activation KW - Antigens KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Vaccines+Containing+Multiple+Comstimulatory+Molecules+Promote+the+Proliferation+and+Activation+of+Human+Antigen+Specific+Memory+CD8+T+Cells&rft.au=Yang%2C+Sixun%3BGrosenbach%2C+Doug%3BSchlom%2C+Jeffrey&rft.aulast=Yang&rft.aufirst=Sixun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Keratin 14 Expression in Mouse Lung Induces Early Squamous Differentiation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964444; 4182127 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dakir, El Habib AU - Feigenbaum, Lionel AU - Linnoila, R Ilona Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung KW - Differentiation KW - Keratin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Keratin+14+Expression+in+Mouse+Lung+Induces+Early+Squamous+Differentiation&rft.au=Dakir%2C+El+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=El&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Tumor Suppressor Gene, hCas, Inhibits Neuroblastoma Tumorigenicity T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39964031; 4182613 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yang, Xuezhong AU - Liu, Zhihui AU - Barenloim-Stapleton, Linda AU - Ried, Thomas AU - London, Wendy AU - Maris, John AU - Thiele, Carol J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Tumor suppressor genes KW - Tumorigenicity KW - Neuroblastoma KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Redundancy+of+DNA+helicases+in+p53-mediated+apoptosis.&rft.au=Spillare%2C+E+A%3BWang%2C+X+W%3Bvon+Kobbe%2C+C%3BBohr%2C+V+A%3BHickson%2C+I+D%3BHarris%2C+C+C&rft.aulast=Spillare&rft.aufirst=E&rft.date=2006-03-30&rft.volume=25&rft.issue=14&rft.spage=2119&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclin E Overexpression Correlates with Inflammation in Breast Cancer T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39958865; 4185205 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Howe, Tiffany M AU - Boersma, Brenda J AU - Goodman, Julie E AU - Yfantis, Harry G AU - Cottrell, John R AU - Prueitt, Robyn L AU - Bowman, Elise D AU - Lee, Dong H AU - Ambs, Stefan Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Inflammation KW - Cyclin E UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cyclin+E+Overexpression+Correlates+with+Inflammation+in+Breast+Cancer&rft.au=Howe%2C+Tiffany+M%3BBoersma%2C+Brenda+J%3BGoodman%2C+Julie+E%3BYfantis%2C+Harry+G%3BCottrell%2C+John+R%3BPrueitt%2C+Robyn+L%3BBowman%2C+Elise+D%3BLee%2C+Dong+H%3BAmbs%2C+Stefan&rft.aulast=Howe&rft.aufirst=Tiffany&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Host Derived Insulin-Like Growth Factor I on Murine Osteosarcoma Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39958853; 4182224 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hong, Sung-Hyeok AU - Newman, Rachel AU - Hoffman, Karen AU - Mendoza, Arnulfo AU - Yakar, Shoshana AU - LeRoith, Derek AU - Helman, Lee AU - Khanna, Chand Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - Insulin-like growth factor I KW - Metastases KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39958853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Role+of+Host+Derived+Insulin-Like+Growth+Factor+I+on+Murine+Osteosarcoma+Metastasis&rft.au=Hong%2C+Sung-Hyeok%3BNewman%2C+Rachel%3BHoffman%2C+Karen%3BMendoza%2C+Arnulfo%3BYakar%2C+Shoshana%3BLeRoith%2C+Derek%3BHelman%2C+Lee%3BKhanna%2C+Chand&rft.aulast=Hong&rft.aufirst=Sung-Hyeok&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Society+for+Biochemistry+and+Molecular+Biology+%28ASBMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peripheral Blood Immunologic Phenotype of Population-Based Post-Menopausal Breast Cancer Cases and Matched Controls T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39956670; 4182776 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Goedert, James J AU - Kopp, William C AU - Pfeiffer, Ruth AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Ortaldo, John R Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Peripheral blood KW - Breast cancer KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Peripheral+Blood+Immunologic+Phenotype+of+Population-Based+Post-Menopausal+Breast+Cancer+Cases+and+Matched+Controls&rft.au=Goedert%2C+James+J%3BKopp%2C+William+C%3BPfeiffer%2C+Ruth%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BOrtaldo%2C+John+R&rft.aulast=Goedert&rft.aufirst=James&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Cells and the Natural History of Cervical HPV Infections T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955872; 4181894 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kovacic, Melinda Butsch AU - Kreimer, Aimee AU - Schiffman, Mark AU - ShermanMark, E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Infection KW - Historical account KW - Cervix UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Immune+Cells+and+the+Natural+History+of+Cervical+HPV+Infections&rft.au=Kovacic%2C+Melinda+Butsch%3BKreimer%2C+Aimee%3BSchiffman%2C+Mark%3BShermanMark%2C+E&rft.aulast=Kovacic&rft.aufirst=Melinda&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction in Frataxin Activates the p53 Stress Pathway: Implications for Friedreichs Ataxia T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955407; 4182428 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Halweg, Christopher J AU - Menendez, Daniel AU - Karthikeyan, Gopalakrishnan AU - Resnick, Michael A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Stress KW - Friedreich's ataxia KW - P53 protein KW - Frataxin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Reduction+in+Frataxin+Activates+the+p53+Stress+Pathway%3A+Implications+for+Friedreichs+Ataxia&rft.au=Halweg%2C+Christopher+J%3BMenendez%2C+Daniel%3BKarthikeyan%2C+Gopalakrishnan%3BResnick%2C+Michael+A&rft.aulast=Halweg&rft.aufirst=Christopher&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of DLC-1 Tumor Suppressor Gene Expression in Breast Cancer Cells by Proapoptotic Dietary Flavone and its Potential Implication in Chemoprevetion T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39955274; 4182990 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ullmannova, Veronika AU - Popescu, Nicolae C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Flavones KW - Tumor suppressor genes KW - Gene expression KW - Tumors KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+DLC-1+Tumor+Suppressor+Gene+Expression+in+Breast+Cancer+Cells+by+Proapoptotic+Dietary+Flavone+and+its+Potential+Implication+in+Chemoprevetion&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicolae+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phased Gene Expression Profiles of the Cell Cycle in Human Leukemic Cell Lines T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39949972; 4181567 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Rustici, Gabriella AU - De Siervi, Adriana AU - Gardner, Kevin Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Cell cycle KW - Leukemia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Phased+Gene+Expression+Profiles+of+the+Cell+Cycle+in+Human+Leukemic+Cell+Lines&rft.au=Rustici%2C+Gabriella%3BDe+Siervi%2C+Adriana%3BGardner%2C+Kevin&rft.aulast=Rustici&rft.aufirst=Gabriella&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bisindolylmaleimide and Indolocarbazole Protein Kinase (PK) Inhibitors Reverse ABCG2-Mediated Drug Transport and Resistance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39944489; 4181960 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Robey, Robert W AU - Shukla, Suneet AU - Steadman, Kenneth AU - Ambudkar, Suresh V AU - Bates, Susan E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Drug resistance KW - Protein kinase KW - Indolocarbazoles KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Bisindolylmaleimide+and+Indolocarbazole+Protein+Kinase+%28PK%29+Inhibitors+Reverse+ABCG2-Mediated+Drug+Transport+and+Resistance&rft.au=Robey%2C+Robert+W%3BShukla%2C+Suneet%3BSteadman%2C+Kenneth%3BAmbudkar%2C+Suresh+V%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication Checkpoint Selectivity for Late S Phase Cells Induced by Topoisomerase I Cleavage Complexes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39940984; 4185452 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Seiler, Jennifer A AU - Syed, Ali AU - Aladjem, Mirit I AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Replication KW - DNA topoisomerase KW - S phase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39940984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Barriers+to+Eye+Care%3A+Results+of+Qualitative+Research&rft.au=Alexander%2C+Robert&rft.aulast=Alexander&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mining the National Cancer Institutes Drug Screening Database in Search for Antineoplastics that Selectively Target MDR1/P-Glycoprotein-Overexpressing Cancer Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39934978; 4183772 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Szakacs, Gergely AU - Chu, Benjamin F AU - Ludwig, Joseph A AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Drugs KW - Drug screening KW - Databases KW - Screening KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Mining+the+National+Cancer+Institutes+Drug+Screening+Database+in+Search+for+Antineoplastics+that+Selectively+Target+MDR1%2FP-Glycoprotein-Overexpressing+Cancer+Cells&rft.au=Szakacs%2C+Gergely%3BChu%2C+Benjamin+F%3BLudwig%2C+Joseph+A%3BGottesman%2C+Michael+M&rft.aulast=Szakacs&rft.aufirst=Gergely&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically Engineered Mouse Cancer Models and Translational Applications T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39932917; 4186438 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Marks, Cheryl L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Translation KW - Animal models KW - Genetic engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Genetically+Engineered+Mouse+Cancer+Models+and+Translational+Applications&rft.au=Marks%2C+Cheryl+L&rft.aulast=Marks&rft.aufirst=Cheryl&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Biomarkers of Arsenic Exposure and Toxicity in Urine Using SELDI Technology T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39929522; 4182812 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Moore, Lee E AU - Skibola, Christine F AU - Hegedus, Christine AU - Skibola, Danica R AU - Pfeiffer, Ruth AU - Warner, Marcella AU - Clark, Michael AU - Steinmaus, Craig AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Smith, Martyn T AU - Smith, Allan H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Heavy metals KW - Bioindicators KW - Arsenic KW - Urine KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+Biomarkers+of+Arsenic+Exposure+and+Toxicity+in+Urine+Using+SELDI+Technology&rft.au=Moore%2C+Lee+E%3BSkibola%2C+Christine+F%3BHegedus%2C+Christine%3BSkibola%2C+Danica+R%3BPfeiffer%2C+Ruth%3BWarner%2C+Marcella%3BClark%2C+Michael%3BSteinmaus%2C+Craig%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T%3BSmith%2C+Allan+H&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Study and Application of RNAi Against Cancer-Related Genes T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928987; 4186075 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Martin, Scott E AU - Jones, Tamara L AU - Thomas, Cheryl L AU - Nguyen, Dac AU - Runfola, Timothy AU - Szakacs, Gergely AU - Gottesman, Michael M AU - Ludwig, Joseph A AU - Weinstein, John N AU - Gunsior, Michele AU - Goldsmith, Paul AU - Lader, Eric AU - Huppi, Konrad AU - Caplen, Natasha J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - RNA-mediated interference UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Study+and+Application+of+RNAi+Against+Cancer-Related+Genes&rft.au=Martin%2C+Scott+E%3BJones%2C+Tamara+L%3BThomas%2C+Cheryl+L%3BNguyen%2C+Dac%3BRunfola%2C+Timothy%3BSzakacs%2C+Gergely%3BGottesman%2C+Michael+M%3BLudwig%2C+Joseph+A%3BWeinstein%2C+John+N%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul%3BLader%2C+Eric%3BHuppi%2C+Konrad%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Haplotype Block in IGF2R Associated with Increased Risk For Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39928596; 4187192 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Savage, Sharon A AU - Modi, William S AU - Douglass, Chester AU - Hoover, Robert N AU - Chanock, Stephen J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - Insulin-like growth factor II receptors KW - Haplotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Identification+of+a+Haplotype+Block+in+IGF2R+Associated+with+Increased+Risk+For+Osteosarcoma&rft.au=Savage%2C+Sharon+A%3BModi%2C+William+S%3BDouglass%2C+Chester%3BHoover%2C+Robert+N%3BChanock%2C+Stephen+J&rft.aulast=Savage&rft.aufirst=Sharon&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Matrix: A Gatekeeper in the Transition from Dormancy to Metastasis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39927780; 4186758 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Barkan, Dalit AU - Costes, Sylvain V AU - Cho, Edward H AU - Simmons, Justin L AU - Asmussen, Holly AU - Kamaraju, Anil K AU - Hoenorhoff, Mark AU - Lockett, Stephen AU - Kleinman, Hynda AU - Chambers, Ann AU - Green, Jeffrey E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Extracellular matrix KW - Metastases KW - Dormancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.atitle=Post-Operative+Serum+Cortisol+for+Prediction+of+Long-Term+Remission+from+Cushing%27s+Syndrome&rft.au=Lindsay%2C+J+R%3BOldfield%2C+E+H%3BNieman%2C+L+K&rft.aulast=Lindsay&rft.aufirst=J&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+European+Congress+of+Endocrinology+%28ECE+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleotide Damage Proximal to DNA Double-Strand Break ends is a Stronger Inhibitor of Non-Homologous end Joining than Blocked 3 Ends T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39925603; 4186637 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Datta, Kamal AU - Neumann, Ronald D AU - Winters, Thomas A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Non-homologous end joining KW - Nucleotides KW - DNA damage KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nucleotide+Damage+Proximal+to+DNA+Double-Strand+Break+ends+is+a+Stronger+Inhibitor+of+Non-Homologous+end+Joining+than+Blocked+3+Ends&rft.au=Datta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Datta&rft.aufirst=Kamal&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Network Profiling of Multiple Myeloma Bone Marrow Aspirates Using Reverse Phase Protein Microarrays T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39922371; 4184817 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sheehan, Katherine M AU - Burington, Bart AU - Rasmussen, Erik AU - Crowley, John AU - Huang, Yongsheng AU - Tricot, Guido AU - Barlogie, Bart AU - Shaughnessy Jr, John D AU - Gulmann, Christian AU - Kay, Elaine W AU - Wulfkuhle, Julia D AU - Liotta, Lance A AU - Petricoin III, Emanuel F. Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Bone marrow KW - Protein arrays KW - Multiple myeloma KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Network+Profiling+of+Multiple+Myeloma+Bone+Marrow+Aspirates+Using+Reverse+Phase+Protein+Microarrays&rft.au=Sheehan%2C+Katherine+M%3BBurington%2C+Bart%3BRasmussen%2C+Erik%3BCrowley%2C+John%3BHuang%2C+Yongsheng%3BTricot%2C+Guido%3BBarlogie%2C+Bart%3BShaughnessy+Jr%2C+John+D%3BGulmann%2C+Christian%3BKay%2C+Elaine+W%3BWulfkuhle%2C+Julia+D%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Sheehan&rft.aufirst=Katherine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor-Induced Downregulation of Interferon Consensus Sequence Binding Protein (ICSBP) in CD11b+Gr-1+ Myeloid Suppressor Cells may Underlie a Mechanism for their Aberrant Expansion and Function T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39922014; 4183046 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Greeneltch, Kristy M AU - Stewart, Trina J AU - Schneider, Monika AU - Liu, Kebin AU - Abrams, Scott I Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Conserved sequence KW - Interferon KW - CD11b antigen KW - Amino acid sequence KW - Suppressor cells KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Tumor-Induced+Downregulation+of+Interferon+Consensus+Sequence+Binding+Protein+%28ICSBP%29+in+CD11b%2BGr-1%2B+Myeloid+Suppressor+Cells+may+Underlie+a+Mechanism+for+their+Aberrant+Expansion+and+Function&rft.au=Greeneltch%2C+Kristy+M%3BStewart%2C+Trina+J%3BSchneider%2C+Monika%3BLiu%2C+Kebin%3BAbrams%2C+Scott+I&rft.aulast=Greeneltch&rft.aufirst=Kristy&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations of the Biophysical Milieu of Membranes Induce Conformational Changes Into Membrane Bound P-Glycoprotein T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39920864; 4183785 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Aszalos, Adorjan AU - Taylor, Barbara AU - Yin, Jun-Jie AU - Chen, Kevin G AU - Cardarelli, Carol AU - Gottesman, Michael M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Membranes KW - P-Glycoprotein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Alterations+of+the+Biophysical+Milieu+of+Membranes+Induce+Conformational+Changes+Into+Membrane+Bound+P-Glycoprotein&rft.au=Aszalos%2C+Adorjan%3BTaylor%2C+Barbara%3BYin%2C+Jun-Jie%3BChen%2C+Kevin+G%3BCardarelli%2C+Carol%3BGottesman%2C+Michael+M&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro and In Vivo Effects of CXCR4 Inhibition in Osteosarcoma T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39920381; 4182208 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Kim, Su Young AU - Midura, Brieanne V AU - Mendoza, Arnulfo AU - Khanna, Chand AU - Korz, Walter AU - Wong, Donald AU - Salari, Hassan AU - Helman, Lee J Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Osteosarcoma KW - CXCR4 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=In+Vitro+and+In+Vivo+Effects+of+CXCR4+Inhibition+in+Osteosarcoma&rft.au=Kim%2C+Su+Young%3BMidura%2C+Brieanne+V%3BMendoza%2C+Arnulfo%3BKhanna%2C+Chand%3BKorz%2C+Walter%3BWong%2C+Donald%3BSalari%2C+Hassan%3BHelman%2C+Lee+J&rft.aulast=Kim&rft.aufirst=Su&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Pathogenesis of Human Hepatocellular Carcinoma: Mechanistic and Prognostic Significance of Aberrant Methylation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39918121; 4182490 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Calvisi, Diego F AU - Ladu, Sara AU - Gorden, Alexis AU - Farina, Miriam AU - Lee, Ju-Seog AU - Conner, Elizabeth A AU - Schroeder, Insa S AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Hepatocellular carcinoma KW - Methylation KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Pathogenesis+of+Human+Hepatocellular+Carcinoma%3A+Mechanistic+and+Prognostic+Significance+of+Aberrant+Methylation&rft.au=Calvisi%2C+Diego+F%3BLadu%2C+Sara%3BGorden%2C+Alexis%3BFarina%2C+Miriam%3BLee%2C+Ju-Seog%3BConner%2C+Elizabeth+A%3BSchroeder%2C+Insa+S%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Calvisi&rft.aufirst=Diego&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sustained Expression of Mect1-Maml2 is Essential for Viability of Salivary Gland Tumors Carrying the t(11;19) Translocation T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39917888; 4182392 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Komiya, Takefumi AU - Park, Yoonsoo AU - Modi, Sanjay AU - Coxon, Amy AU - Oh, Hye AU - Kaye, Frederic Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Salivary gland KW - Translocation KW - Tumors KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Sustained+Expression+of+Mect1-Maml2+is+Essential+for+Viability+of+Salivary+Gland+Tumors+Carrying+the+t%2811%3B19%29+Translocation&rft.au=Komiya%2C+Takefumi%3BPark%2C+Yoonsoo%3BModi%2C+Sanjay%3BCoxon%2C+Amy%3BOh%2C+Hye%3BKaye%2C+Frederic&rft.aulast=Komiya&rft.aufirst=Takefumi&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of Cancer Disparities: Barriers to Cancer Screening, Diagnosis, and Treatment T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39896060; 4183299 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Chu, Kenneth C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Screening KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Determinants+of+Cancer+Disparities%3A+Barriers+to+Cancer+Screening%2C+Diagnosis%2C+and+Treatment&rft.au=Chu%2C+Kenneth+C&rft.aulast=Chu&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Topoisomerase I-DNA Complexes: An Early and General Process of Programmed Cell Death Induced by TRAIL, Fas, Tubulin Inhibitors, BH3 Mimetics and DNA Targeted Agents T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39894428; 4185493 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Sordet, Olivier AU - Rao, Ashutosh V AU - Goldman, Abby AU - Almanza, Carlos AU - Pommier, Yves Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mortality KW - Apoptosis KW - CD95 antigen KW - TRAIL protein KW - Tubulin KW - Fas antigen KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Apoptotic+Topoisomerase+I-DNA+Complexes%3A+An+Early+and+General+Process+of+Programmed+Cell+Death+Induced+by+TRAIL%2C+Fas%2C+Tubulin+Inhibitors%2C+BH3+Mimetics+and+DNA+Targeted+Agents&rft.au=Sordet%2C+Olivier%3BRao%2C+Ashutosh+V%3BGoldman%2C+Abby%3BAlmanza%2C+Carlos%3BPommier%2C+Yves&rft.aulast=Sordet&rft.aufirst=Olivier&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxic Gene Therapy of Esophageal Cancers Using the Recombinant RGD-Modified Adenovirus Expressing Membrane-Bound TRAIL (TNF-Related Apoptosis-Inducing Ligand): An In Vitro and In Vivo Analysis T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39893714; 4187308 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Nguyen, Duc M AU - Sehgal, Shailen AU - Fang, Bingliang AU - Schrump, David S AU - Nguyen, Dao M Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - TRAIL protein KW - Cytotoxicity KW - Gene therapy KW - Ligands KW - Recombinants KW - Adenovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cytotoxic+Gene+Therapy+of+Esophageal+Cancers+Using+the+Recombinant+RGD-Modified+Adenovirus+Expressing+Membrane-Bound+TRAIL+%28TNF-Related+Apoptosis-Inducing+Ligand%29%3A+An+In+Vitro+and+In+Vivo+Analysis&rft.au=Yeow%2C+Wen-Shuz%3BChua%2C+Alex%3BNguyen%2C+Duc+M%3BSehgal%2C+Shailen%3BFang%2C+Bingliang%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Yeow&rft.aufirst=Wen-Shuz&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemoprevention and Therapeutic Treatment of BRCA1 Associated Breast Cancer in Conditional Knockout Mice T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892871; 4182102 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Tominaga, Yohei AU - De Soto III, Joseph A. AU - Wang, Rui-Hong AU - Deng, Chu-Xia Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mice KW - Breast cancer KW - BRCA1 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Chemoprevention+and+Therapeutic+Treatment+of+BRCA1+Associated+Breast+Cancer+in+Conditional+Knockout+Mice&rft.au=Tominaga%2C+Yohei%3BDe+Soto+III%2C+Joseph+A.%3BWang%2C+Rui-Hong%3BDeng%2C+Chu-Xia&rft.aulast=Tominaga&rft.aufirst=Yohei&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Menopausal Hormone Therapy and Ovarian Cancer Risk T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892288; 4181891 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Lacey Jr, James V AU - Brinton, Louise A AU - Leitzmann, Michael F AU - Mouw, Traci AU - Hartge, Patricia AU - Hollenbeck, Albert R AU - Schatzkin, Arthur Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Ovarian cancer KW - Hormones KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Menopausal+Hormone+Therapy+and+Ovarian+Cancer+Risk&rft.au=Lacey+Jr%2C+James+V%3BBrinton%2C+Louise+A%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BHartge%2C+Patricia%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Lacey+Jr&rft.aufirst=James&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Patterns Distinguish Human Aberrant Crypt Foci from Normal Colonic Mucosa T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39892004; 4181798 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Glebov, Oleg K AU - Rodriguez, Luz M AU - Soballe, Peter AU - DeNobile, John AU - Cliatt, Janet AU - Nakahara, Kenneth AU - Kirsch, Ilan R Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Gene expression KW - Mucosa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Gene+Expression+Patterns+Distinguish+Human+Aberrant+Crypt+Foci+from+Normal+Colonic+Mucosa&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaphostin Induced Toxicity in Lung Tumor Cell Lines Implicates Oxidative Stress that is Mediated through the Nrf-2/Heme Oxygenase Pathway T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39891314; 4184048 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Reifsnider, Nicole D AU - Hose, Curtis D AU - Monks, Anne Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Toxicity KW - Lung KW - Stress KW - GA-binding protein KW - Oxidative stress KW - Tumor cell lines KW - Heme oxygenase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Adaphostin+Induced+Toxicity+in+Lung+Tumor+Cell+Lines+Implicates+Oxidative+Stress+that+is+Mediated+through+the+Nrf-2%2FHeme+Oxygenase+Pathway&rft.au=Reifsnider%2C+Nicole+D%3BHose%2C+Curtis+D%3BMonks%2C+Anne&rft.aulast=Reifsnider&rft.aufirst=Nicole&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cox-2 and Other Inflammatory Response Proteins Mediate Prevention of Human Papilloma Virus (HPV) E7-Driven Tumorigenesis by Dominant Negative Cjun (TAM67) T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885984; 4184854 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Matthews, Connie P AU - Young, Matthew R AU - Colburn, Nancy H Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Prevention KW - Tumorigenesis KW - Inflammation KW - Cyclooxygenase-2 KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Cox-2+and+Other+Inflammatory+Response+Proteins+Mediate+Prevention+of+Human+Papilloma+Virus+%28HPV%29+E7-Driven+Tumorigenesis+by+Dominant+Negative+Cjun+%28TAM67%29&rft.au=Matthews%2C+Connie+P%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H&rft.aulast=Matthews&rft.aufirst=Connie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo Molecular Imaging of Disseminated Peritoneal Cancer Microfoci Using a Targeted Optical Fluorescence Agent Conjugated to Avidin T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39885354; 4184728 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Kamiya, Mako AU - Bernardo, Marcelino AU - Paik, Ronald S AU - Krishna, Murali C AU - Choyke, Peter L AU - Kobayashi, Hisataka Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Fluorescence KW - Cancer KW - Imaging techniques KW - Avidin KW - Peritoneum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=In+vivo+Molecular+Imaging+of+Disseminated+Peritoneal+Cancer+Microfoci+Using+a+Targeted+Optical+Fluorescence+Agent+Conjugated+to+Avidin&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BKamiya%2C+Mako%3BBernardo%2C+Marcelino%3BPaik%2C+Ronald+S%3BKrishna%2C+Murali+C%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overexpression of BP1 Confers a More Aggressive Phenotype on MCF7 Breast Cancer Cells T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39884248; 4185068 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Ginsburg, Erika AU - Fu, Sidney AU - Campbell, Cassandra L AU - Baxter, Kristin K AU - Kluk, Brian AU - Vonderhaar, Barbara AU - Berg, Patricia E Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Breast cancer KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Overexpression+of+BP1+Confers+a+More+Aggressive+Phenotype+on+MCF7+Breast+Cancer+Cells&rft.au=Ginsburg%2C+Erika%3BFu%2C+Sidney%3BCampbell%2C+Cassandra+L%3BBaxter%2C+Kristin+K%3BKluk%2C+Brian%3BVonderhaar%2C+Barbara%3BBerg%2C+Patricia+E&rft.aulast=Ginsburg&rft.aufirst=Erika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of ETS Transcription Factors in the HIF-2 Target Gene Selection T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879726; 4186080 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Aprelikova, Olga AU - Wood, Matthew AU - Tackett, Sean AU - Chandramouli, G.V.R. AU - Barrett, J.Carl Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - ETS protein KW - Transcription factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Role+of+ETS+Transcription+Factors+in+the+HIF-2+Target+Gene+Selection&rft.au=Aprelikova%2C+Olga%3BWood%2C+Matthew%3BTackett%2C+Sean%3BChandramouli%2C+G.V.R.%3BBarrett%2C+J.Carl&rft.aulast=Aprelikova&rft.aufirst=Olga&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age-Related Eye Diseases Study (AREDS): Past Findings and Current Efforts, and How it Relates to Public Health T2 - 3rd Annual International Health Conference of the Unite For Sight AN - 39879615; 4194585 JF - 3rd Annual International Health Conference of the Unite For Sight AU - Huang, Lynn L Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Public health KW - Eye diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.atitle=Age-Related+Eye+Diseases+Study+%28AREDS%29%3A+Past+Findings+and+Current+Efforts%2C+and+How+it+Relates+to+Public+Health&rft.au=Huang%2C+Lynn+L&rft.aulast=Huang&rft.aufirst=Lynn&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+International+Health+Conference+of+the+Unite+For+Sight&rft.issn=&rft_id=info:doi/ L2 - http://www.uniteforsight.org/2006_annual_conference.php#cliffocallahan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Role of Elevated PhosphoSTAT5a in 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine-Induced Rat Mammary Gland Carcinomas T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39879324; 4185994 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Papaconstantinou, Andriana D AU - Snyderwine, Elizabeth G Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Mammary gland KW - Carcinoma KW - Tumors KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Possible+Role+of+Elevated+PhosphoSTAT5a+in+2-Amino-1-Methyl-6-Phenylimidazo%5B4%2C5-b%5DPyridine-Induced+Rat+Mammary+Gland+Carcinomas&rft.au=Papaconstantinou%2C+Andriana+D%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opening Comments on the NanoAlliance T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39877670; 4181542 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Barker, Anna D Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Global+Gene+Expression+Profiling+of+Mucinous+Ovarian+Tumors+and+Cystadenomas+Identifies+Genes+of+Clinicopathologic+Importance&rft.au=Wamunyokoli%2C+Fred+W+A%3BBonome%2C+Tomas%3BLee%2C+Ji-Young%3BFeltmate%2C+Colleen+M%3BWelch%2C+William+R%3BRadonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBrady%2C+John%3BHao%2C+Ke%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel%3BBirrer%2C+Michael+J&rft.aulast=Wamunyokoli&rft.aufirst=Fred+W&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of MAP3K8 Levels in Lung Cancer Cell Lines and the Effects on Downstream Pathways T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39876311; 4183418 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Dempsey, Jamie M AU - Pandey, Jyotsna AU - Gunsior, Michele AU - Goldsmith, Paul AU - Wiest, Jonathan S Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Lung cancer KW - Tumor cell lines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Differential+Expression+of+MAP3K8+Levels+in+Lung+Cancer+Cell+Lines+and+the+Effects+on+Downstream+Pathways&rft.au=Dempsey%2C+Jamie+M%3BPandey%2C+Jyotsna%3BGunsior%2C+Michele%3BGoldsmith%2C+Paul%3BWiest%2C+Jonathan+S&rft.aulast=Dempsey&rft.aufirst=Jamie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV Protease Inhibitors as Cancer Therapeutics: Is Off-The-Shelf Right on Target? T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39860099; 4184513 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Gills, Joell J AU - Lopiccolo, Jaclyn AU - Abu-Asab, Mones S AU - Shoemaker, Robert AU - Borojerdi, Jennifer AU - Dennis, Phillip A Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer KW - Proteinase inhibitors KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=HIV+Protease+Inhibitors+as+Cancer+Therapeutics%3A+Is+Off-The-Shelf+Right+on+Target%3F&rft.au=Gills%2C+Joell+J%3BLopiccolo%2C+Jaclyn%3BAbu-Asab%2C+Mones+S%3BShoemaker%2C+Robert%3BBorojerdi%2C+Jennifer%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Closing Remarks and Introduction of Mentors T2 - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AN - 39859339; 4186552 JF - 97th Annual Meeting of the American Association for the Cancer Research (AACR 2006) AU - Johnson, Alfred C Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Closing+Remarks+and+Introduction+of+Mentors&rft.au=Johnson%2C+Alfred+C&rft.aulast=Johnson&rft.aufirst=Alfred&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B3B61E3 56%2D411F%2D435F%2DACCA%2D167F0FDA48AD%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Redundancy of DNA helicases in p53-mediated apoptosis. AN - 67811986; 16288211 AB - A subset of DNA helicases, the RecQ family, has been found to be associated with the p53-mediated apoptotic pathway and is involved in maintaining genomic integrity. This family contains the BLM and WRN helicases, in which germline mutations are responsible for Bloom and Werner syndromes, respectively. TFIIH DNA helicases, XPB and XPD, are also components in this apoptotic pathway. We hypothesized that there may be some redundancy between helicases in their ability to complement the attenuated p53-mediated apoptotic levels seen in cells from individuals with diseases associated with these defective helicase genes. The attenuated apoptotic phenotype in Bloom syndrome cells was rescued not only by ectopic expression of BLM, but also by WRN or XPB, both 3' --> 5' helicases, but not expression of the 5' --> 3' helicase XPD. Overexpression of Sgs1, a WRN/BLM yeast homolog, corrected the reduction in BS cells only, which is consistent with Sgs1 being evolutionarily most homologous to BLM. A restoration of apoptotic levels in cells from WS, XPB or XPD patients was attained only by overexpression of the specific helicase. Our data suggest a limited redundancy in the pathways of these RecQ helicases in p53-induced apoptosis. JF - Oncogene AU - Spillare, E A AU - Wang, X W AU - von Kobbe, C AU - Bohr, V A AU - Hickson, I D AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 SP - 2119 EP - 2123 VL - 25 IS - 14 SN - 0950-9232, 0950-9232 KW - Tumor Suppressor Protein p53 KW - 0 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Werner Syndrome -- enzymology KW - Humans KW - Germ-Line Mutation KW - Bloom Syndrome -- enzymology KW - Tumor Suppressor Protein p53 -- physiology KW - DNA Helicases -- metabolism KW - Apoptosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67811986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Redundancy+of+DNA+helicases+in+p53-mediated+apoptosis.&rft.au=Spillare%2C+E+A%3BWang%2C+X+W%3Bvon+Kobbe%2C+C%3BBohr%2C+V+A%3BHickson%2C+I+D%3BHarris%2C+C+C&rft.aulast=Spillare&rft.aufirst=E&rft.date=2006-03-30&rft.volume=25&rft.issue=14&rft.spage=2119&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-26 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2001 Aug;8(2):351-61 [11545737] Cancer Res. 2005 Jul 1;65(13):5520-2 [15994923] Acta Oncol. 2001;40(6):696-701 [11765063] J Biol Chem. 2002 Jun 14;277(24):22035-44 [11919194] Mutat Res. 2002 Jul 25;504(1-2):157-72 [12106656] Mol Cell Biol. 2002 Oct;22(20):6971-8 [12242278] J Biol Chem. 2002 Oct 25;277(43):41110-9 [12181313] Hum Mol Genet. 2002 Dec 1;11(25):3135-44 [12444098] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] Genes Cells. 1999 Nov;4(11):619-25 [10620009] J Biol Chem. 2000 Feb 11;275(6):4258-66 [10660593] Mutat Res. 2000 Apr 28;459(3):203-9 [10812332] J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Cytogenet Cell Genet. 2000;91(1-4):217-23 [11173860] EMBO J. 2001 Feb 15;20(4):905-13 [11179234] J Biol Chem. 2001 Aug 31;276(35):32948-55 [11399766] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] J Cell Sci. 2003 Oct 15;116(Pt 20):4077-85 [12972501] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Oncogene. 2004 Jan 8;23(1):149-56 [14712220] Trends Pharmacol Sci. 2004 Apr;25(4):177-81 [15116721] Eur J Biochem. 2004 May;271(10):1849-63 [15128295] Carcinogenesis. 2004 Jul;25(7):1077-81 [15205365] Cell. 1990 Aug 24;62(4):777-91 [2167179] EMBO J. 1994 Apr 1;13(7):1645-53 [8157004] Genes Dev. 1996 May 15;10(10):1219-32 [8675009] EMBO J. 1996 Jul 15;15(14):3693-701 [8758936] Genetics. 1996 Nov;144(3):935-45 [8913739] Cell. 1997 Feb 7;88(3):323-31 [9039259] EMBO J. 1997 Oct 1;16(19):5955-65 [9312053] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8733-8 [9671747] EMBO J. 1999 Mar 1;18(5):1357-66 [10064601] Mol Biol Cell. 1999 Mar;10(3):665-76 [10069810] Genes Dev. 1999 Jun 1;13(11):1355-60 [10364153] J Biol Chem. 1999 Jun 25;274(26):18341-50 [10373438] J Biol Chem. 1999 Aug 6;274(32):22127-30 [10428772] Annu Rev Genomics Hum Genet. 2000;1:409-59 [11701636] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Clinical Approach to Diagnosing Immune Mechanisms of Ocular Surface Disease T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40159915; 4148097 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Smith, J A AU - Reed, G AU - Vitale, S AU - Chan, C-C Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Immunology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40159915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Clinical+Approach+to+Diagnosing+Immune+Mechanisms+of+Ocular+Surface+Disease&rft.au=Smith%2C+J+A%3BReed%2C+G%3BVitale%2C+S%3BChan%2C+C-C&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Blindness Despite Steroid Therapy T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40143795; 4148032 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Nussenblatt, R B Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Blindness KW - Steroid hormones KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40143795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Prevalence+of+Blindness+Despite+Steroid+Therapy&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Nutrition and Supplementation in Age-Related Macular Degeneration T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40125960; 4148051 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Cooney, M J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Nutrition KW - Supplementation KW - Macular degeneration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40125960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=The+Role+of+Nutrition+and+Supplementation+in+Age-Related+Macular+Degeneration&rft.au=Cooney%2C+M+J&rft.aulast=Cooney&rft.aufirst=M&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Zenapax Therapy for Uveitis T2 - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AN - 40101566; 4148023 JF - 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT 2006) AU - Nussenblatt, R B Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Uveitis KW - Zenapax KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.atitle=Zenapax+Therapy+for+Uveitis&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Symposium+on+Ocular+Pharmacology+and+Therapeutics+%28ISOPT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isopt2004/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CT-Integrated Treatment Planning for Thermal Ablation with Intraprocedural Adaptive Modifications. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 40006847; 4208904 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Wood, B AU - Bauer, C AU - Viswanathan, A AU - Kruecker, J AU - Haemmerich, D AU - Yanof, J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Possible+Role+of+Elevated+PhosphoSTAT5a+in+2-Amino-1-Methyl-6-Phenylimidazo%5B4%2C5-b%5DPyridine-Induced+Rat+Mammary+Gland+Carcinomas&rft.au=Papaconstantinou%2C+Andriana+D%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diagnostic and Interventional CT Shielding: A Dramatic Decrease in Scattered Radiation for Patients. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39995809; 4208837 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Neeman, Z AU - Jacobus, J AU - Oberoi, J AU - Sudheendra, D AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Diagnostic+and+Interventional+CT+Shielding%3A+A+Dramatic+Decrease+in+Scattered+Radiation+for+Patients.&rft.au=Neeman%2C+Z%3BJacobus%2C+J%3BOberoi%2C+J%3BSudheendra%2C+D%3BWood%2C+B+J&rft.aulast=Neeman&rft.aufirst=Z&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electromagnetic Tracking of Surgical Devices for Multimodality Navigation during Interventions. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39990474; 4208706 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Viswanathan, A AU - Glossop, N AU - Kruecker, J AU - Xu, S. AU - Locklin, J AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39990474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Electromagnetic+Tracking+of+Surgical+Devices+for+Multimodality+Navigation+during+Interventions.&rft.au=Viswanathan%2C+A%3BGlossop%2C+N%3BKruecker%2C+J%3BXu%2C+S.%3BLocklin%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Evaluation of Haptic Feedback Tools for CT-Guided Robotic Interventions. T2 - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AN - 39953154; 4208894 JF - 31st Annual Scientific Meeting of the Society of Interventional Radiology (SIR 2006) AU - Viswanathan, A AU - Yanof, J H AU - Bauer, C AU - Xu, S. AU - Kruecker, J AU - Wood, B J Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 KW - Robotics KW - Feedback KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39953154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.atitle=Preliminary+Evaluation+of+Haptic+Feedback+Tools+for+CT-Guided+Robotic+Interventions.&rft.au=Viswanathan%2C+A%3BYanof%2C+J+H%3BBauer%2C+C%3BXu%2C+S.%3BKruecker%2C+J%3BWood%2C+B+J&rft.aulast=Viswanathan&rft.aufirst=A&rft.date=2006-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Meeting+of+the+Society+of+Interventional+Radiology+%28SIR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sirmeeting.org/index.cfm?fuseaction=Custom.Content&MenuID=1 000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of the Crossover Outcome of Meiotic Recombination T2 - 2006 Conference of the Biochemical Society and the Genetics Society on Meiosis AN - 40065575; 4219203 JF - 2006 Conference of the Biochemical Society and the Genetics Society on Meiosis AU - Lichten, Michael Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Recombination KW - Meiosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40065575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Aryl+Hydrocarbon+Receptor+Repressor%2C+a+Candidate+Tumor+Suppressor+Gene&rft.au=Zudaire%2C+Enrique%3BCuesta%2C+Natalia%3BMurty%2C+Vundavalli%3BMartinez%2C+Alfredo%3BNarayan%2C+Gopeshwar%3BBirrer%2C+Mike%3BKirsch%2C+IlanR%3BCuttitta%2C+Frank&rft.aulast=Zudaire&rft.aufirst=Enrique&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biochemistry.org/meetings/programme.cfm?Meeting_No=SA049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Pattern of H4AcK16 Location on the Male X Chromosome T2 - 47th Annual Drosophila Research Conference AN - 40041079; 4195248 JF - 47th Annual Drosophila Research Conference AU - Zhang, Yu AU - Gupta, Vaijayanti AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Chromosomes KW - X chromosome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40041079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Global+Pattern+of+H4AcK16+Location+on+the+Male+X+Chromosome&rft.au=Zhang%2C+Yu%3BGupta%2C+Vaijayanti%3BOliver%2C+Brian&rft.aulast=Zhang&rft.aufirst=Yu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Foiled Coil Gene is Required for Testis Elongation and Coiling T2 - 47th Annual Drosophila Research Conference AN - 40040788; 4195122 JF - 47th Annual Drosophila Research Conference AU - Smith, John AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Coiling KW - Elongation KW - Testes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40040788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Foiled+Coil+Gene+is+Required+for+Testis+Elongation+and+Coiling&rft.au=Smith%2C+John%3BOliver%2C+Brian&rft.aulast=Smith&rft.aufirst=John&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is there a Telomere-Linked Stress Response in Drosophila? T2 - 47th Annual Drosophila Research Conference AN - 40037285; 4195246 JF - 47th Annual Drosophila Research Conference AU - Mason, James M AU - Biessmann, Harald AU - Walter, Marika F AU - Bradley, Tim Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Stress KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40037285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Is+there+a+Telomere-Linked+Stress+Response+in+Drosophila%3F&rft.au=Mason%2C+James+M%3BBiessmann%2C+Harald%3BWalter%2C+Marika+F%3BBradley%2C+Tim&rft.aulast=Mason&rft.aufirst=James&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pairing-Sensitive Elements Regulate Polycomb Responsiveness and Enhancer-Promoter Interactions at the Drosophila engrailed gene T2 - 47th Annual Drosophila Research Conference AN - 40035283; 4195259 JF - 47th Annual Drosophila Research Conference AU - Kassis, Judith AU - DeVido, Sarah AU - Kwon, Deborah Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Engrailed gene KW - Polycomb group proteins KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40035283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Pairing-Sensitive+Elements+Regulate+Polycomb+Responsiveness+and+Enhancer-Promoter+Interactions+at+the+Drosophila+engrailed+gene&rft.au=Kassis%2C+Judith%3BDeVido%2C+Sarah%3BKwon%2C+Deborah&rft.aulast=Kassis&rft.aufirst=Judith&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Drosophila Lipid Droplet-Associated Proteins T2 - 47th Annual Drosophila Research Conference AN - 40028186; 4195596 JF - 47th Annual Drosophila Research Conference AU - Beller, Mathias AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Lipids KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40028186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Opening+Comments+on+the+NanoAlliance&rft.au=Barker%2C+Anna+D&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decoding CIS-Regulatory Sequences Involved in Neural Precursor Coordinate Gene Regulation T2 - 47th Annual Drosophila Research Conference AN - 40027783; 4195677 JF - 47th Annual Drosophila Research Conference AU - Brody, Thomas AU - Rasband, Wayne AU - Baler, Kevin AU - Kuzin, Alexander AU - Odenwald, Ward Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Decoding+CIS-Regulatory+Sequences+Involved+in+Neural+Precursor+Coordinate+Gene+Regulation&rft.au=Brody%2C+Thomas%3BRasband%2C+Wayne%3BBaler%2C+Kevin%3BKuzin%2C+Alexander%3BOdenwald%2C+Ward&rft.aulast=Brody&rft.aufirst=Thomas&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishing the Incidence of Putative Genetic Modifiers in DNA Samples of Newborns with Sickle Cell Disease from a State Newborn Screening Program T2 - 67th Annual Meeting of the Association of Southeastern Biologists (ASB 2006) AN - 40002283; 4205861 JF - 67th Annual Meeting of the Association of Southeastern Biologists (ASB 2006) AU - Cobb, Crystal AU - Ackah, Diana AU - Carolyn, Hoppe M.D. AU - James, G. Taylor VI M.D. Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Neonates KW - Sickle cell disease KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.atitle=Establishing+the+Incidence+of+Putative+Genetic+Modifiers+in+DNA+Samples+of+Newborns+with+Sickle+Cell+Disease+from+a+State+Newborn+Screening+Program&rft.au=Cobb%2C+Crystal%3BAckah%2C+Diana%3BCarolyn%2C+Hoppe+M.D.%3BJames%2C+G.+Taylor+VI+M.D.&rft.aulast=Cobb&rft.aufirst=Crystal&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=67th+Annual+Meeting+of+the+Association+of+Southeastern+Biologists+%28ASB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asb.appstate.edu/ASB%202006%20schedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Dynamin Function in Membrane Trafficking during Early Drosophila Embryogenesis T2 - 47th Annual Drosophila Research Conference AN - 39996510; 4194988 JF - 47th Annual Drosophila Research Conference AU - Rikhy, Richa AU - Mavrakis, Manos AU - Lippincott-Schwartz, Jennifer Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Membranes KW - Embryogenesis KW - Dynamin KW - Membrane trafficking KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39996510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Characterization+of+Dynamin+Function+in+Membrane+Trafficking+during+Early+Drosophila+Embryogenesis&rft.au=Rikhy%2C+Richa%3BMavrakis%2C+Manos%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Rikhy&rft.aufirst=Richa&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An O-Glycosyltransferase is Required during Multiple Stages of Drosophila Development T2 - 47th Annual Drosophila Research Conference AN - 39993632; 4195455 JF - 47th Annual Drosophila Research Conference AU - Tian, E AU - Hagen, Kelly G. Ten Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Developmental stages KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=An+O-Glycosyltransferase+is+Required+during+Multiple+Stages+of+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nerfin-1 Gene and mRNA Regulation: Enhancer and miRNA Analysis T2 - 47th Annual Drosophila Research Conference AN - 39993440; 4195425 JF - 47th Annual Drosophila Research Conference AU - Kuzin, Alexander AU - Kundu, Mukta AU - Brody, Thomas AU - Odenwald, Ward F Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - MiRNA KW - Transcription KW - Enhancers KW - Gene regulation KW - MRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Nerfin-1+Gene+and+mRNA+Regulation%3A+Enhancer+and+miRNA+Analysis&rft.au=Kuzin%2C+Alexander%3BKundu%2C+Mukta%3BBrody%2C+Thomas%3BOdenwald%2C+Ward+F&rft.aulast=Kuzin&rft.aufirst=Alexander&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Terminal Telomeric Region is Euchromatic in Drosophila melanogaster T2 - 47th Annual Drosophila Research Conference AN - 39987334; 4195244 JF - 47th Annual Drosophila Research Conference AU - Prasad, Sudha AU - Biessmann, Harald AU - Semeshin, Valery F AU - Andreyeva, Eugenia N AU - Walter, Marika F AU - Nguyen, Quang AU - Mason, James M Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Chromosomes KW - Genomes KW - Drosophila melanogaster UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39987334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Terminal+Telomeric+Region+is+Euchromatic+in+Drosophila+melanogaster&rft.au=Prasad%2C+Sudha%3BBiessmann%2C+Harald%3BSemeshin%2C+Valery+F%3BAndreyeva%2C+Eugenia+N%3BWalter%2C+Marika+F%3BNguyen%2C+Quang%3BMason%2C+James+M&rft.aulast=Prasad&rft.aufirst=Sudha&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Rap-GEF/Rap GTPase Signaling Controls Stem Cell Anchoring to their Niche through Regulating DE-Cadherin-Mediated Cell Adhesion in the Drosophila Testis T2 - 47th Annual Drosophila Research Conference AN - 39983947; 4195739 JF - 47th Annual Drosophila Research Conference AU - Zheng, Zhiyu AU - Hong, Wang AU - Singh, Shree Ram AU - Oh, Su-wan AU - Chen, Xiu Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Signal transduction KW - Cell adhesion KW - Guanosinetriphosphatase KW - Testes KW - Stem cells KW - Anchoring KW - Niches KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=A+Rap-GEF%2FRap+GTPase+Signaling+Controls+Stem+Cell+Anchoring+to+their+Niche+through+Regulating+DE-Cadherin-Mediated+Cell+Adhesion+in+the+Drosophila+Testis&rft.au=Zheng%2C+Zhiyu%3BHong%2C+Wang%3BSingh%2C+Shree+Ram%3BOh%2C+Su-wan%3BChen%2C+Xiu&rft.aulast=Zheng&rft.aufirst=Zhiyu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Density Tiling Path and Multiple-Species Expression Arrays T2 - 47th Annual Drosophila Research Conference AN - 39945422; 4195789 JF - 47th Annual Drosophila Research Conference AU - Zhang, Yu AU - Sturgill, David AU - Oliver, Brian Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=High+Density+Tiling+Path+and+Multiple-Species+Expression+Arrays&rft.au=Zhang%2C+Yu%3BSturgill%2C+David%3BOliver%2C+Brian&rft.aulast=Zhang&rft.aufirst=Yu&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Telomeric Retrotransposons may be Stimulated by Terminal Deficiencies in Trans T2 - 47th Annual Drosophila Research Conference AN - 39945419; 4195247 JF - 47th Annual Drosophila Research Conference AU - Frydrychova, Radmila Capkova AU - Archer, Trevor AU - Mason, James Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Retrotransposons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Regulation+of+Cell+Spreading+and+Migration+by+Candidate+Tumor+Suppressor+ING4&rft.au=Shen%2C+Jiang+C%3BKumamoto%2C+Kensuke%3BUnoki%2C+Motoko%3BVarticovski%2C+Lyuba%3BPedeux%2C+Remy%3BHarris%2C+Curtis+C&rft.aulast=Shen&rft.aufirst=Jiang&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Drosophila Homologue of the Human Tumor Suppressor Gene BHD Regulates Male Germline Stem Cell Maintenance and Functions Downstream of Dpp T2 - 47th Annual Drosophila Research Conference AN - 39937191; 4195032 JF - 47th Annual Drosophila Research Conference AU - Singh, Shree R AU - Zen, Wei AU - Zheng, Zhiyu AU - Wang, Hong AU - Oh, Su-Wan AU - Liu, Wei AU - Zbar, Berton AU - Schmidt, Laura S AU - Hou, Steven X Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Tumor suppressor genes KW - Stem cells KW - Tumors KW - Suppressors KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39937191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=The+Drosophila+Homologue+of+the+Human+Tumor+Suppressor+Gene+BHD+Regulates+Male+Germline+Stem+Cell+Maintenance+and+Functions+Downstream+of+Dpp&rft.au=Singh%2C+Shree+R%3BZen%2C+Wei%3BZheng%2C+Zhiyu%3BWang%2C+Hong%3BOh%2C+Su-Wan%3BLiu%2C+Wei%3BZbar%2C+Berton%3BSchmidt%2C+Laura+S%3BHou%2C+Steven+X&rft.aulast=Singh&rft.aufirst=Shree&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dacapo Promotes the Licensing of DNA Replication Origins during Drosophila Endocycles T2 - 47th Annual Drosophila Research Conference AN - 39936154; 4194929 JF - 47th Annual Drosophila Research Conference AU - Lilly, Mary AU - Hong, Amy AU - Narbonne, Karine AU - Fu, Haiquing AU - Aladjem, Mirit Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Licensing KW - Replication origins KW - DNA biosynthesis KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39936154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Dacapo+Promotes+the+Licensing+of+DNA+Replication+Origins+during+Drosophila+Endocycles&rft.au=Lilly%2C+Mary%3BHong%2C+Amy%3BNarbonne%2C+Karine%3BFu%2C+Haiquing%3BAladjem%2C+Mirit&rft.aulast=Lilly&rft.aufirst=Mary&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhodopsin-Mutant Induced Changes in Drosophila Retinal Gene Expression T2 - 47th Annual Drosophila Research Conference AN - 39906090; 4195680 JF - 47th Annual Drosophila Research Conference AU - Padilla, Robert M AU - Li, Moyi AU - Edmundson, Christine AU - Davidson, Florence F Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene expression KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Rhodopsin-Mutant+Induced+Changes+in+Drosophila+Retinal+Gene+Expression&rft.au=Dissanayake%2C+Samudra+K%3BRosenthal%2C+Devin+T%3BHewitt%2C+Kyle+J%3BYang%2C+Sherry%3BWade%2C+Michael%3BTaub%2C+Dennis+D%3BNickoloff%2C+Brian+J%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael%3BRiker%2C+Adam+I%3BWeeraratna%2C+Ashani+T&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Drosophila Tis11 T2 - 47th Annual Drosophila Research Conference AN - 39905970; 4195649 JF - 47th Annual Drosophila Research Conference AU - Fedic, Robert AU - Kennington, Elisabeth A AU - Blackshear, Perry J AU - Mason, James M Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Gene expression KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Characterization+of+Drosophila+Tis11&rft.au=Fedic%2C+Robert%3BKennington%2C+Elisabeth+A%3BBlackshear%2C+Perry+J%3BMason%2C+James+M&rft.aulast=Fedic&rft.aufirst=Robert&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational Identification of Regulatory Elements in Drosophila Core Promoters: Is there a "Core Promoter Code?". T2 - 47th Annual Drosophila Research Conference AN - 39905499; 4195551 JF - 47th Annual Drosophila Research Conference AU - Sturgill, David AU - FitzGerald, Peter AU - Shyakhtenko, Andrey AU - Oliver, Brian AU - Vinson, Charles Y1 - 2006/03/29/ PY - 2006 DA - 2006 Mar 29 KW - Promoters KW - Cores KW - Computer applications KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Drosophila+Research+Conference&rft.atitle=Computational+Identification+of+Regulatory+Elements+in+Drosophila+Core+Promoters%3A+Is+there+a+%22Core+Promoter+Code%3F%22.&rft.au=Sturgill%2C+David%3BFitzGerald%2C+Peter%3BShyakhtenko%2C+Andrey%3BOliver%2C+Brian%3BVinson%2C+Charles&rft.aulast=Sturgill&rft.aufirst=David&rft.date=2006-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://genetics.faseb.org/genetics/dros06/dros06s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Rac GTPase signaling through the PP5 protein phosphatase. AN - 67810890; 16549782 AB - We have investigated the Rac-dependent mechanism of KCNH2 channel stimulation by thyroid hormone in a rat pituitary cell line, GH(4)C(1), with the patch-clamp technique. Here we present physiological evidence for the protein serine/threonine phosphatase, PP5, as an effector of Rac GTPase signaling. We also propose and test a specific molecular mechanism for PP5 stimulation by Rac-GTP. Inhibition of PP5 with the microbial toxin, okadaic acid, blocked channel stimulation by thyroid hormone and by Rac, but signaling was restored by expression of a toxin-insensitive mutant of PP5, Y451A, which we engineered. PP5 is unique among protein phosphatases in that it contains an N-terminal regulatory domain with three tetratricopeptide repeats (TPR) that inhibit its activity. Expression of the TPR domain coupled to GFP blocked channel stimulation by the thyroid hormone. We also show that the published structures of the PP5 TPR domain and the TPR domain of p67, the Rac-binding subunit of NADPH oxidase, superimpose over 92 alpha carbons. Mutation of the PP5 TPR domain at two predicted contact points with Rac-GTP prevents the TPR domain from functioning as a dominant negative and blocks the ability of Y451A to rescue signaling in the presence of okadaic acid. PP5 stimulation by Rac provides a unique molecular mechanism for the antagonism of Rho-dependent signaling through protein kinases in many cellular processes, including metastasis, immune cell chemotaxis, and neuronal development. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gentile, Saverio AU - Darden, Thomas AU - Erxleben, Christian AU - Romeo, Charles AU - Russo, Angela AU - Martin, Negin AU - Rossie, Sandra AU - Armstrong, David L AD - Environmental Biology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 SP - 5202 EP - 5206 VL - 103 IS - 13 SN - 0027-8424, 0027-8424 KW - ERG1 Potassium Channel KW - 0 KW - Ether-A-Go-Go Potassium Channels KW - KCNH2 protein, human KW - Kcnh2 protein, rat KW - Nuclear Proteins KW - Potassium Channels, Voltage-Gated KW - Thyroid Hormones KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Tyrosine KW - 42HK56048U KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - protein phosphatase 5 KW - rac GTP-Binding Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Thyroid Hormones -- pharmacology KW - Models, Molecular KW - Amino Acid Sequence KW - Electrophysiology KW - Protein Structure, Quaternary KW - Ion Channel Gating -- drug effects KW - Rats KW - Patch-Clamp Techniques KW - Sequence Alignment KW - Molecular Sequence Data KW - Okadaic Acid -- pharmacology KW - Tyrosine -- genetics KW - Tyrosine -- metabolism KW - Potassium Channels, Voltage-Gated -- metabolism KW - Cell Line KW - rac GTP-Binding Proteins -- metabolism KW - rac GTP-Binding Proteins -- chemistry KW - Nuclear Proteins -- genetics KW - Phosphoprotein Phosphatases -- metabolism KW - Phosphoprotein Phosphatases -- genetics KW - Phosphoprotein Phosphatases -- chemistry KW - Nuclear Proteins -- chemistry KW - Nuclear Proteins -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Rac+GTPase+signaling+through+the+PP5+protein+phosphatase.&rft.au=Gentile%2C+Saverio%3BDarden%2C+Thomas%3BErxleben%2C+Christian%3BRomeo%2C+Charles%3BRusso%2C+Angela%3BMartin%2C+Negin%3BRossie%2C+Sandra%3BArmstrong%2C+David+L&rft.aulast=Gentile&rft.aufirst=Saverio&rft.date=2006-03-28&rft.volume=103&rft.issue=13&rft.spage=5202&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-10 N1 - Date created - 2006-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2000 Oct;6(4):899-907 [11090627] Trends Biochem Sci. 2005 Apr;30(4):194-204 [15817396] Brain Res Mol Brain Res. 2001 Jun 20;90(2):101-9 [11406288] EMBO J. 2001 Nov 1;20(21):6028-36 [11689443] J Biol Chem. 2001 Nov 23;276(47):44078-82 [11535607] Trends Cell Biol. 2001 Dec;11(12):471-7 [11719051] Curr Biol. 2002 Jan 8;12(1):27-33 [11790300] Trends Neurosci. 2002 Apr;25(4):191-9 [11998687] Curr Biol. 2002 Aug 6;12(15):1353-8 [12176367] Curr Med Chem. 2002 Nov;9(22):2055-75 [12369870] FEBS Lett. 2003 Jul 3;546(1):93-7 [12829242] Physiol Rev. 2003 Jul;83(3):965-1016 [12843413] Physiol Rev. 2003 Oct;83(4):1325-58 [14506307] Curr Opin Cell Biol. 2003 Oct;15(5):583-9 [14519393] Science. 2003 Nov 14;302(5648):1215-7 [14615541] Trends Biochem Sci. 2003 Dec;28(12):655-62 [14659697] Cell. 2004 Jan 23;116(2):167-79 [14744429] J Cell Mol Med. 2004 Jan-Mar;8(1):22-30 [15090257] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Trends Neurosci. 1992 Oct;15(10):403-8 [1279866] FEBS Lett. 1993 Dec 28;336(3):433-9 [8282106] Biochemistry. 1996 Feb 6;35(5):1606-11 [8634292] J Biol Chem. 1996 Dec 13;271(50):32315-20 [8943293] FEBS Lett. 1997 Jan 2;400(1):136-40 [9000529] J Biol Chem. 1997 Sep 5;272(36):22464-71 [9278397] EMBO J. 1998 Mar 2;17(5):1192-9 [9482716] J Physiol. 1998 Aug 15;511 ( Pt 1):3-14 [9679158] J Biol Chem. 1999 Aug 13;274(33):23666-72 [10438550] J Biol Chem. 1999 Sep 24;274(39):27457-62 [10488078] Genes Dev. 2005 Jan 1;19(1):1-49 [15630019] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5197-201 [16549781] J Biol Chem. 2005 Jan 21;280(3):1790-6 [15546861] EMBO J. 2005 Jan 12;24(1):1-10 [15577939] J Biol Chem. 2005 Feb 11;280(6):4532-43 [15579468] Biochem J. 2005 Mar 1;386(Pt 2):201-14 [15548136] Trends Cell Biol. 2005 Mar;15(3):163-71 [15752980] Trends Endocrinol Metab. 2001 Jan-Feb;12(1):28-32 [11137038] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenously administered vitamin C as cancer therapy: three cases. AN - 67796770; 16567755 AB - Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer. Double-blind placebo-controlled studies of oral vitamin C therapy showed no benefit. Recent evidence shows that oral administration of the maximum tolerated dose of vitamin C (18 g/d) produces peak plasma concentrations of only 220 micromol/L, whereas intravenous administration of the same dose produces plasma concentrations about 25-fold higher. Larger doses (50-100 g) given intravenously may result in plasma concentrations of about 14,000 micromol/L. At concentrations above 1000 micromol/L, vitamin C is toxic to some cancer cells but not to normal cells in vitro. We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy. We examined clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines. Tumour pathology was verified by pathologists at the NCI who were unaware of diagnosis or treatment. In light of recent clinical pharmacokinetic findings and in vitro evidence of anti-tumour mechanisms, these case reports indicate that the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed. JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne AU - Padayatty, Sebastian J AU - Riordan, Hugh D AU - Hewitt, Stephen M AU - Katz, Arie AU - Hoffer, L John AU - Levine, Mark AD - Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md 20892-1372, USA. Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 SP - 937 EP - 942 VL - 174 IS - 7 KW - Vitamins KW - 0 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Abridged Index Medicus KW - Index Medicus KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Kidney Neoplasms -- drug therapy KW - Lymphoma, B-Cell -- drug therapy KW - Ascorbic Acid -- therapeutic use KW - Ascorbic Acid -- administration & dosage KW - Vitamins -- therapeutic use KW - Vitamins -- administration & dosage KW - Urinary Bladder Neoplasms -- drug therapy KW - Carcinoma, Renal Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67796770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.atitle=Intravenously+administered+vitamin+C+as+cancer+therapy%3A+three+cases.&rft.au=Padayatty%2C+Sebastian+J%3BRiordan%2C+Hugh+D%3BHewitt%2C+Stephen+M%3BKatz%2C+Arie%3BHoffer%2C+L+John%3BLevine%2C+Mark&rft.aulast=Padayatty&rft.aufirst=Sebastian&rft.date=2006-03-28&rft.volume=174&rft.issue=7&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=CMAJ+%3A+Canadian+Medical+Association+journal+%3D+journal+de+l%27Association+medicale+canadienne&rft.issn=1488-2329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Urol Oncol. 2003 Nov-Dec;21(6):468-74 [14693275] J Urol. 2004 Feb;171(2 Pt 1):561-9 [14713760] Oncologist. 2004;9(1):80-9 [14755017] Integr Cancer Ther. 2003 Jun;2(2):158-9 [15035904] P R Health Sci J. 2004 Jun;23(2):115-8 [15377059] Oncology. 1969;23(1):33-43 [5774953] Chem Biol Interact. 1974 Oct;9(4):285-315 [4430016] Chem Biol Interact. 1975 Nov;11(5):387-93 [1104207] Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9 [1068480] Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42 [279931] N Engl J Med. 1979 Sep 27;301(13):687-90 [384241] Scott Med J. 1979 Apr;24(2):151-3 [227054] Nature. 1980 Apr 17;284(5757):629-31 [7366735] JAMA. 1984 Oct 5;252(13):1684 [6471294] N Engl J Med. 1985 Jan 17;312(3):137-41 [3880867] N Engl J Med. 1985 Jan 17;312(3):178-9 [3965937] J Natl Med Assoc. 2000 Jun;92(6):285-94 [10918764] J Am Coll Nutr. 2000 Aug;19(4):423-5 [10963459] CMAJ. 2001 Feb 6;164(3):351-3 [11232135] CMAJ. 2001 Feb 6;164(3):353-5 [11232136] Br J Cancer. 2001 Jun 1;84(11):1544-50 [11384106] Circulation. 2001 Jun 12;103(23):E117 [11401949] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9842-6 [11504949] Oncology (Williston Park). 2001 Oct;15(10):1267-72; discussion 1272-8, 1283 [11702957] Clin Cancer Res. 2002 Dec;8(12):3658-68 [12473574] Semin Oncol. 2002 Dec;29(6):546-51 [12516037] Semin Oncol. 2002 Dec;29(6):552-62 [12516038] CMAJ. 2003 Jan 21;168(2):180-2 [12538547] Gynecol Oncol. 2003 Mar;88(3):434-9 [12648599] J Am Coll Nutr. 2003 Apr;22(2):118-23 [12672707] BMJ. 2003 Jun 28;326(7404):1453-5 [12829562] Ann N Y Acad Sci. 1987;498:445-54 [3304071] J Urol. 1987 Nov;138(5):1162-3 [3669160] Med Hypotheses. 1991 Nov;36(3):190-4 [1787808] J Urol. 1992 Jun;147(6):1513-5 [1593678] Anticancer Res. 1993 Mar-Apr;13(2):475-80 [8517665] Aust N Z J Med. 1994 Aug;24(4):410-1 [7980244] Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9 [8623000] World J Urol. 1996;14(3):175-81 [8806196] Am J Clin Oncol. 1997 Aug;20(4):416-8 [9256902] JAMA. 1999 Apr 21;281(15):1415-23 [10217058] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9 [16157892] Ann Intern Med. 2004 Apr 6;140(7):533-7 [15068981] Comment In: CMAJ. 2006 Mar 28;174(7):956-7 [16567756] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Immunodominance Rules T2 - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AN - 40003913; 4143131 JF - 2006 Keystone Symposia on Viral Immunity: From Basic Mechanisms to Vaccines (X7) AU - Bennink, Jack R Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Immunodominance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.atitle=Immunodominance+Rules&rft.au=Bennink%2C+Jack+R&rft.aulast=Bennink&rft.aufirst=Jack&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Viral+Immunity%3A+From+Basic+Mechanisms+to+Vaccines+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=801 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Live Attenuated Pandemic Vaccines T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39906046; 4143208 JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - Subbarao, Kanta Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Vaccines KW - Pandemics KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=Evaluation+of+Live+Attenuated+Pandemic+Vaccines&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PB1-F2: What Does it Do and How Does it Do it? T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39905964; 4143192 DE: JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - Yewdell, Jonathan W Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=PB1-F2%3A+What+Does+it+Do+and+How+Does+it+Do+it%3F&rft.au=Yewdell%2C+Jonathan+W&rft.aulast=Yewdell&rft.aufirst=Jonathan&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigenic Relatedness Among Avian Influenza A H7 Subtype Viruses with Post Infection Mouse Sera T2 - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AN - 39802982; 4143189 JF - 2006 Keystone Symposia on Advances in Influenza Research: From Birds to Bench to Bedside AU - McAuliffe, Josephine M Y1 - 2006/03/28/ PY - 2006 DA - 2006 Mar 28 KW - Infection KW - Viruses KW - Fowl plague UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39802982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.atitle=Antigenic+Relatedness+Among+Avian+Influenza+A+H7+Subtype+Viruses+with+Post+Infection+Mouse+Sera&rft.au=McAuliffe%2C+Josephine+M&rft.aulast=McAuliffe&rft.aufirst=Josephine&rft.date=2006-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+Influenza+Research%3A+From+Birds+to+Bench+to+Bedside&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toll-Like Receptor Ligands Influence the Magnitude and Quality of HIV Specific Immune Responses in Non-Human Primates T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 40008792; 4150868 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Seder, Robert A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Toll-like receptors KW - Ligands KW - Human immunodeficiency virus KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40008792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Toll-Like+Receptor+Ligands+Influence+the+Magnitude+and+Quality+of+HIV+Specific+Immune+Responses+in+Non-Human+Primates&rft.au=Seder%2C+Robert+A&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circumventing CD4 Deficiency to Induce Long-Lived Memory CTL T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39956046; 4150917 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Berzofsky, Jay A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Memory cells KW - Cytotoxicity KW - Lymphocytes T KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39956046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Circumventing+CD4+Deficiency+to+Induce+Long-Lived+Memory+CTL&rft.au=Berzofsky%2C+Jay+A&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunization with Vaccinia Virus Induces Polyfunctional T Cell Responses T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39955999; 4150901 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Precopio, Melissa L Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Immunization KW - Lymphocytes T KW - Vaccinia virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39955999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Immunization+with+Vaccinia+Virus+Induces+Polyfunctional+T+Cell+Responses&rft.au=Precopio%2C+Melissa+L&rft.aulast=Precopio&rft.aufirst=Melissa&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Regulatory T Cell Markers and Indoleamine 2,3 Dioxygenase in Spleen and Gut of SIV-Infected Macaques T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39951782; 4150887 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Boasso, Adriano Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Digestive tract KW - Lymphocytes T KW - Immunoregulation KW - Dioxygenase KW - Spleen KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39951782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Increased+Regulatory+T+Cell+Markers+and+Indoleamine+2%2C3+Dioxygenase+in+Spleen+and+Gut+of+SIV-Infected+Macaques&rft.au=Boasso%2C+Adriano&rft.aulast=Boasso&rft.aufirst=Adriano&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Immunity Following Systemic SIV DNA Priming/Mucosal Replication-Competent Ad-SIV Boosting of Rhesus Macaques is Enhanced by Cytokine DNAs and Includes Potent Mucosal CD8+T Cell Memory Responses T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39922193; 4150918 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Robert-Guroff, Marjorie Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Cytokines KW - Immunological memory KW - Immunity (cell-mediated) KW - Immunity KW - Simian immunodeficiency virus KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Cellular+Immunity+Following+Systemic+SIV+DNA+Priming%2FMucosal+Replication-Competent+Ad-SIV+Boosting+of+Rhesus+Macaques+is+Enhanced+by+Cytokine+DNAs+and+Includes+Potent+Mucosal+CD8%2BT+Cell+Memory+Responses&rft.au=Robert-Guroff%2C+Marjorie&rft.aulast=Robert-Guroff&rft.aufirst=Marjorie&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenicity and Protective Efficacy of Prime/Boost Vaccine Regimens Based on Replication-Competent Ad Recombinants Encoding HIVtat, HIVenv, SIVgag, and SIVnef in a Rhesus Macaque SHIV89.6P Challenge Model T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39921748; 4150894 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Demberg, Thorsten Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Vaccines KW - Immunogenicity KW - Models KW - Recombinants KW - Disease control KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Immunogenicity+and+Protective+Efficacy+of+Prime%2FBoost+Vaccine+Regimens+Based+on+Replication-Competent+Ad+Recombinants+Encoding+HIVtat%2C+HIVenv%2C+SIVgag%2C+and+SIVnef+in+a+Rhesus+Macaque+SHIV89.6P+Challenge+Model&rft.au=Demberg%2C+Thorsten&rft.aulast=Demberg&rft.aufirst=Thorsten&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Envelope Glycoprotein Structural Analysis for Improved Immunogen Design T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39916156; 4150879 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Wyatt, Richard T Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Structural analysis KW - Envelopes KW - Glycoproteins KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39916156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=HIV-1+Envelope+Glycoprotein+Structural+Analysis+for+Improved+Immunogen+Design&rft.au=Wyatt%2C+Richard+T&rft.aulast=Wyatt&rft.aufirst=Richard&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DC-SIGN Capture of HIV gp120 Relies on Avidity Effects, and is Altered by CD4 Ligation T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39914863; 4150869 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Van Ryk, Donald I Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Avidity KW - CD4 antigen KW - Glycoprotein gp120 KW - DC-SIGN protein KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39914863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=DC-SIGN+Capture+of+HIV+gp120+Relies+on+Avidity+Effects%2C+and+is+Altered+by+CD4+Ligation&rft.au=Van+Ryk%2C+Donald+I&rft.aulast=Van+Ryk&rft.aufirst=Donald&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39906235; 4143279 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Price, David A Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Vaccines KW - CD8 antigen KW - Antigen presentation KW - Major histocompatibility complex KW - Antigens KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Functional+Consequences+of+Peptide-Major+Histocompatibility+Complex+Class+I+Antigen+Presentation+in+the+Context+of+Enhanced+CD8+Coreceptor+Binding%3A+Implications+for+Vaccine+Delivery&rft.au=Price%2C+David+A&rft.aulast=Price&rft.aufirst=David&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stem Cell Renewal and Regeneration in the CNS T2 - 2006 Keystone Symposia on Stem Cells (G4) AN - 39901442; 4142045 JF - 2006 Keystone Symposia on Stem Cells (G4) AU - McKay, Ronald D Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Central nervous system KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Stem+Cells+%28G4%29&rft.atitle=Stem+Cell+Renewal+and+Regeneration+in+the+CNS&rft.au=McKay%2C+Ronald+D&rft.aulast=McKay&rft.aufirst=Ronald&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Stem+Cells+%28G4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Antigen Designs for Env Responses T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39895609; 4143271 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Nabel, Gary J Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=New+Antigen+Designs+for+Env+Responses&rft.au=Nabel%2C+Gary+J&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recombination and Complementation: Two Modes of Interactions Among HIVs T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39895576; 4143255 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Hu, Wei-Shau Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Recombination KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Recombination+and+Complementation%3A+Two+Modes+of+Interactions+Among+HIVs&rft.au=Hu%2C+Wei-Shau&rft.aulast=Hu&rft.aufirst=Wei-Shau&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39893355; 4143294 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Brenchley, Jason M Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antiretroviral agents KW - Infection KW - Lymphocytes T KW - Antiretroviral therapy KW - CD4 antigen KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Continued+Infection+of+Mucosal+CD4%2B+T+Cells+is+Associated+with+Mucosal+Depletion+Despite+Years+of+Antiretroviral+Therapy&rft.au=Brenchley%2C+Jason+M&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39893014; 4143285 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Duvall, Melody G Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Infection KW - Lymphocytes T KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Proteomic+Profiling+Distinguishes+Astrocytomas+of+Different+Grades+and+Identifies+Differential+Tumor+Markers&rft.au=Li%2C+Jie%3BWeil%2C+Robert%3BOkamoto%2C+Hiroaki%3BVortmeyer%2C+Alexander%3BLubensky%2C+Irina%3BPark%2C+Deric%3BFuruta%2C+Makoto%3BLee%2C+Youn-Soo%3BZeng%2C+Weifen%3BOldfield%2C+Edward+H%3BZhuang%2C+Zhengping&rft.aulast=Li&rft.aufirst=Jie&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39892954; 4143261 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Strebel, Klaus Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Infectivity KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=Degradation+of+APOBEC3G+and+Rescue+of+Viral+Infectivity+are+Separable+Activities+of+HIV-1+Vif&rft.au=Strebel%2C+Klaus&rft.aulast=Strebel&rft.aufirst=Klaus&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on VRC Clinical Trials T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39880736; 4150903 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Graham, Barney S Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=The+Imprinted+Adaptor+Protein+Grb10+Interacts+Genetically+with+Nf1%2Fp53+in+Development+and+Tumorigenesis&rft.au=Reilly%2C+Karlyne+M%3BTuskan%2C+Robert%3BKumar%2C+Krishan%3BStewart%2C+Colin%3BHagan%2C+John%3BFox%2C+Kristi&rft.aulast=Reilly&rft.aufirst=Karlyne&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of the Neutralizing Specificity in Complex Polyclonal Sera T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39879070; 4150921 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Li, Yuxing Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Analysis+of+the+Neutralizing+Specificity+in+Complex+Polyclonal+Sera&rft.au=Li%2C+Yuxing&rft.aulast=Li&rft.aufirst=Yuxing&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of CD4+ T Cells in the Maintenance of SIV-Specific CD8+ T Memory Cells and their Role in Protection from SIVmac251 T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39864407; 4150900 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Franchini, Genoveffa Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Memory cells KW - CD8 antigen KW - Lymphocytes T KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39864407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=Importance+of+CD4%2B+T+Cells+in+the+Maintenance+of+SIV-Specific+CD8%2B+T+Memory+Cells+and+their+Role+in+Protection+from+SIVmac251&rft.au=Franchini%2C+Genoveffa&rft.aulast=Franchini&rft.aufirst=Genoveffa&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6 T2 - 2006 Keystone Symposia on HIV Pathogenesis (X5) AN - 39840571; 4143262 JF - 2006 Keystone Symposia on HIV Pathogenesis (X5) AU - Lee, Kyeongeun Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Target cells KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.atitle=HIV-1+Cell+Killing+Blocked+by+Pre-mRNA+Factor+CPSF6&rft.au=Lee%2C+Kyeongeun&rft.aulast=Lee&rft.aufirst=Kyeongeun&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Pathogenesis+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=805 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CTLA4 Blockade in Antiretroviral Therapy-Treated SIVmac251-Infected Macaques Does Not Augment Global T Cell Activation and Viral Replication T2 - 2006 Keystone Symposia on HIV Vaccines (X6) AN - 39789678; 4150911 JF - 2006 Keystone Symposia on HIV Vaccines (X6) AU - Vaccari, Monica Y1 - 2006/03/27/ PY - 2006 DA - 2006 Mar 27 KW - Antiretroviral agents KW - Replication KW - CTLA-4 protein KW - Lymphocytes T KW - Cell activation KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39789678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.atitle=CTLA4+Blockade+in+Antiretroviral+Therapy-Treated+SIVmac251-Infected+Macaques+Does+Not+Augment+Global+T+Cell+Activation+and+Viral+Replication&rft.au=Vaccari%2C+Monica&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2006-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+HIV+Vaccines+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pseudorotational Cycle as a Tool for Drug Design and Discovery T2 - 231st National Meeting of the American Chemical Society AN - 40129966; 4118547 JF - 231st National Meeting of the American Chemical Society AU - Marquez, Victor E Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Drug development KW - Drug discovery KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=The+Pseudorotational+Cycle+as+a+Tool+for+Drug+Design+and+Discovery&rft.au=Marquez%2C+Victor+E&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products as Inhibitors and Mechanistic Probes in Infectious Diseases T2 - 231st National Meeting of the American Chemical Society AN - 40103080; 4118369 JF - 231st National Meeting of the American Chemical Society AU - Bewley, Carole A Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - infectious diseases KW - Inhibitors KW - Probes KW - natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40103080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Marine+Natural+Products+as+Inhibitors+and+Mechanistic+Probes+in+Infectious+Diseases&rft.au=Bewley%2C+Carole+A&rft.aulast=Bewley&rft.aufirst=Carole&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery? T2 - 231st National Meeting of the American Chemical Society AN - 40061651; 4118367 JF - 231st National Meeting of the American Chemical Society AU - Newman, David J Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Drug discovery KW - natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40061651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Natural+Products+as+Leads+to+Potential+Drugs%3A+An+Old+Process+or+the+New+Hope+for+Drug+Discovery%3F&rft.au=Newman%2C+David+J&rft.aulast=Silva&rft.aufirst=Aloisio&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Symbiotic relationship of pharmacogenetics and drugs of abuse. AN - 67828507; 16584126 AB - Pharmacogenetics/pharmacogenomics is the study of how genetic variation affects pharmacology, the use of drugs to treat disease. When drug responses are predicted in advance, it is easier to tailor medications to different diseases and individuals. Pharmacogenetics provides the tools required to identify genetic predictors of probable drug response, drug efficacy, and drug-induced adverse events-identifications that would ideally precede treatment decisions. Drug abuse and addiction genetic data have advanced the field of pharmacogenetics in general. Although major findings have emerged, pharmacotherapy remains hindered by issues such as adverse events, time lag to drug efficacy, and heterogeneity of the disorders being treated. The sequencing of the human genome and high-throughput technologies are enabling pharmacogenetics to have greater influence on treatment approaches. This review highlights key studies and identifies important genes in drug abuse pharmacogenetics that provide a basis for better diagnosis and treatment of drug abuse disorders. JF - The AAPS journal AU - Rutter, Joni L AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Boulevard, Bethesda, MD 20892, USA. jrutter@mail.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - E174 EP - E184 VL - 8 IS - 1 KW - Street Drugs KW - 0 KW - Index Medicus KW - Humans KW - Genetic Variation -- genetics KW - Pharmacogenetics -- methods KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Symbiotic+relationship+of+pharmacogenetics+and+drugs+of+abuse.&rft.au=Rutter%2C+Joni+L&rft.aulast=Rutter&rft.aufirst=Joni&rft.date=2006-03-24&rft.volume=8&rft.issue=1&rft.spage=E174&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 2005 Jun;81(2):381-6 [15925402] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] J Med Genet. 2005 Jul;42(7):583-7 [15994880] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] J Neurochem. 2005 Jul;94(2):352-9 [15998286] Pharmacogenomics J. 2005;5(4):218-20 [16041391] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12938-43 [16118273] J Biol Chem. 2005 Sep 23;280(38):32618-24 [16046395] PLoS Med. 2005 Sep;2(9):e266; 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author reply 1445-7 [15178784] Arch Gen Psychiatry. 2004 Jun;61(6):597-606 [15184239] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Arch Gen Psychiatry. 1998 Nov;55(11):973-9 [9819065] J Am Med Inform Assoc. 2005 Mar-Apr;12(2):121-9 [15561790] J Pain. 2005 Mar;6(3):159-67 [15772909] Pharmacogenomics J. 2005;5(2):89-95 [15772696] Am J Hum Genet. 2005 May;76(5):859-64 [15759211] Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):5-9 [15729709] Trends Pharmacol Sci. 2005 Jun;26(6):311-7 [15925706] Neuropsychopharmacology. 2005 Jul;30(7):1374-82 [15827573] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhancement of functional antibody responses to AMA1- C1/Alhydrogel super([registered]), a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide AN - 17070564; 6698522 AB - Apical membrane antigen 1 (AMA1) has been shown to be a promising malaria vaccine candidate. The multiallelic AMA1-C1 vaccine currently in Phase 1 trials in the US and Mali contains an equal mixture of the ectodomain portion of recombinant AMA1 from the FVO and 3D7 clones of Plasmodium falciparum, formulated on Alhydrogel. It is hoped that inclusion of a human-optimized CpG oligodeoxynucleotide (ODN) (CPG 7909) with our existing AMA1-C1/Alhydrogel vaccine will lead to a higher concentration of functional AMA1-C1 antibodies. Preclinical studies were performed in mice, rats and guinea pigs to assess the safety, immunogenicity and functionality of the immune response to AMA1-C1 with Alhydrogel + CPG 7909 compared to antigen with Alhydrogel alone. Day 42 mean anti-AMA1 ELISA titer values derived from individual animals were compared between Alhydrogel and Alhydrogel + CPG 7909 groups at each antigen dose for each species. Sera from Alhydrogel + CPG 7909 groups displayed significantly higher antibody titers (P - 0.025) than their comparable Alhydrogel alone group. Mouse IgG isotype analysis showed that AMA1-C1/Alhydrogel induced a predominately Th2 type response while AMA1-C1/Alhydrogel + CPG 7909 gave a mixed Th1/Th2 type response. When tested for functional activity by in vitro inhibition of parasite invasion, IgG isolated from serum pools of AMA1- C1/Alhydrogel + CPG 7909 animals was more effective against both FVO and 3D7 parasites than an equal concentration of IgG from animals receiving vaccines adjuvanted with Alhydrogel alone. These promising preclinical results have recently led to the start of a Phase 1 trial in the US. JF - Vaccine AU - Mullen, Gregory ED AU - Giersing, Birgitte K AU - Ajose-Popoola, Olubunmi AU - Davis, Heather L AU - Kothe, Cheryl AU - Zhou, Hong AU - Aebig, Joan AU - Dobrescu, Gelu AU - Saul, Allan AU - Long, Carole A AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, gmullen@niaid.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2497 EP - 2505 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Apical membrane antigen 1 KW - Parasites KW - Helper cells KW - Malaria KW - Oligonucleotides KW - Lymphocytes T KW - Enzyme-linked immunosorbent assay KW - CpG islands KW - Plasmodium falciparum KW - Immunogenicity KW - Immunoglobulin G KW - Immune response KW - Vaccines KW - K 03086:Immunology & vaccination KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17070564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhancement+of+functional+antibody+responses+to+AMA1-+C1%2FAlhydrogel+super%28%5Bregistered%5D%29%2C+a+Plasmodium+falciparum+malaria+vaccine%2C+with+CpG+oligodeoxynucleotide&rft.au=Mullen%2C+Gregory+ED%3BGiersing%2C+Birgitte+K%3BAjose-Popoola%2C+Olubunmi%3BDavis%2C+Heather+L%3BKothe%2C+Cheryl%3BZhou%2C+Hong%3BAebig%2C+Joan%3BDobrescu%2C+Gelu%3BSaul%2C+Allan%3BLong%2C+Carole+A&rft.aulast=Mullen&rft.aufirst=Gregory&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2497&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.12.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Plasmodium falciparum; CpG islands; Vaccines; Helper cells; Immunoglobulin G; Lymphocytes T; Oligonucleotides; Parasites; Malaria; Apical membrane antigen 1; Immunogenicity; Enzyme-linked immunosorbent assay; Immune response DO - http://dx.doi.org/10.1016/j.vaccine.2005.12.034 ER - TY - JOUR T1 - Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates AN - 17068488; 6698543 AB - The P/C gene of human parainfluenza virus type 1 (HPIV1) encodes a nested set of related accessory C proteins, C'/C/Y1/Y2, which have been shown in other paramyxoviruses to have a role in evasion of the type I interferon (IFN) response following virus infection. We previously demonstrated that a set of two amino acid substitutions, C super(R84G)/HN super(T553A), and a separate amino acid substitution, C super(F170S), are independently attenuating for HPIV1 in African green monkeys (AGMs). However, in each case the attenuation (att) phenotype is vulnerable to reversion by a single nucleotide change back to wild type. Using reverse genetics, recombinant HPIV1 (rHPIV1) vaccine candidates were generated that were designed for increased genetic and phenotypic stability by: (i) creating a two-amino acid deletion and substitution at the site of the C super(F170S) mutation, yielding C super( Delta 170); (ii) introducing a six amino acid deletion in the N-terminal region of C, C super( Delta 10-15); and (iii) combining these stable deletion mutations with the att C super(R84G)/HN super(T553A) mutation. The resulting rHPIV1 vaccine candidates were evaluated for attenuation in hamsters and AGMs and for immunogenicity and protective efficacy in AGMs. The C super( Delta 10- 15) mutation was attenuating in hamsters but not in AGMs, and likely will be of limited value for an HPIV1 vaccine. Conversely, the C super(R84G)/HN super(T553A) mutation set was attenuating in AGMs but not in hamsters. Thus, these two mutations demonstrated reciprocal host range phenotypes involving different regions of C. The C super( Delta 170) mutation conferred a significant level of attenuation in hamsters and AGMs that closely resembled that of C super(F170S) and will be of particular utility for vaccine development because it involves a deletion of six nucleotides rendering it highly refractory to reversion. The combination of the C super(R84G)/HN super(T553A) mutation set and the C super( Delta 170) deletion mutation yielded a virus, rC super(R84G/ Delta 170)HN super(T553A), that exhibited a satisfactory level of attenuation in hamsters and AGMs and was immunogenic and highly protective against HPIV1 wt challenge. This virus will be evaluated clinically as a live intranasal HPIV1 vaccine, one that can be further attenuated as necessary by the introduction of additional stabilized att mutations previously developed in the L protein. JF - Vaccine AU - Bartlett, Emmalene J AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Collins, Peter L AU - Murphy, Brian R AU - Skiadopoulos, Mario H AD - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bldg 50, Room 6511, 50 South Drive MSC 8007; Bethesda, MD 20892-8007, USA, EBartlett@niaid.nih.gov Y1 - 2006/03/24/ PY - 2006 DA - 2006 Mar 24 SP - 2674 EP - 2684 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 14 SN - 0264-410X, 0264-410X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Human parainfluenza virus KW - Attenuating mutations KW - Interferon antagonist KW - Vaccine candidates KW - Non-human primate study KW - double prime L protein KW - Host range KW - Amino acid substitution KW - Reversion KW - double prime C gene KW - Infection KW - Nucleotides KW - Parainfluenza virus KW - Parainfluenza KW - Interferon KW - Gene deletion KW - Immunogenicity KW - double prime C protein KW - Vaccines KW - Mutation KW - W3 33365:Vaccines (other) KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17068488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Introducing+point+and+deletion+mutations+into+the+P%2FC+gene+of+human+parainfluenza+virus+type+1+%28HPIV1%29+by+reverse+genetics+generates+attenuated+and+efficacious+vaccine+candidates&rft.au=Bartlett%2C+Emmalene+J%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSkiadopoulos%2C+Mario+H&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2006-03-24&rft.volume=24&rft.issue=14&rft.spage=2674&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.10.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - double prime L protein; Amino acid substitution; Host range; Reversion; Infection; double prime C gene; Nucleotides; Parainfluenza; Interferon; Gene deletion; Immunogenicity; double prime C protein; Vaccines; Mutation; Parainfluenza virus DO - http://dx.doi.org/10.1016/j.vaccine.2005.10.047 ER - TY - JOUR T1 - Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. AN - 67756196; 16539384 AB - This paper examines two biological models of anticancer activity, cytotoxicity and hollow fiber (HF) activity, for chemotherapeutic agents evaluated as part of the National Cancer Institute's (NCI's) drug screening effort. Our analysis proposes strategies to globally assess compounds tested in the NCI's 60-cell (NCI60) in vitro anticancer screen in terms of structural features, biological activity, target specificity, and mechanism of action by data integration via our self-organizing maps of structural and biological response patterns. We have built statistical models to predict compound potency and HF activity based on physicochemical properties. Our results find that it is the combination of different structural properties that determines a compound's biological activity. A direct correlation is also found between compound potency and specificity, indicating that specific targeting, rather than promiscuous poisoning, gives rise to potency. Finally, we offer a strategy to exploit this relationship for future mining of novel anticancer candidates. JF - Journal of medicinal chemistry AU - Huang, Ruili AU - Wallqvist, Anders AU - Covell, David G AD - Developmental Therapeutics Program, Screening Technologies Branch, Laboratory of Computational Technologies, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA. Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 SP - 1964 EP - 1979 VL - 49 IS - 6 SN - 0022-2623, 0022-2623 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - United States KW - National Institutes of Health (U.S.) KW - Databases, Factual KW - Drug Screening Assays, Antitumor KW - Quantitative Structure-Activity Relationship KW - Models, Statistical KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67756196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Assessment+of+in+vitro+and+in+vivo+activities+in+the+National+Cancer+Institute%27s+anticancer+screen+with+respect+to+chemical+structure%2C+target+specificity%2C+and+mechanism+of+action.&rft.au=Huang%2C+Ruili%3BWallqvist%2C+Anders%3BCovell%2C+David+G&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2006-03-23&rft.volume=49&rft.issue=6&rft.spage=1964&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Roles of NF-kappaB in Control of Autoimmunity T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 40006123; 4141937 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Siebenlist, Ulrich K Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Roles+of+NF-kappaB+in+Control+of+Autoimmunity&rft.au=Siebenlist%2C+Ulrich+K&rft.aulast=Siebenlist&rft.aufirst=Ulrich&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Becoming an NCI-Approved Clinical Investigator T2 - 59th Annual Cancer Symposium of the Society of Surgical Oncology (SSO 2006) AN - 39982595; 4195897 DE: JF - 59th Annual Cancer Symposium of the Society of Surgical Oncology (SSO 2006) AU - Mooney, Margaret M Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39982595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Cancer+Symposium+of+the+Society+of+Surgical+Oncology+%28SSO+2006%29&rft.atitle=Becoming+an+NCI-Approved+Clinical+Investigator&rft.au=Mooney%2C+Margaret+M&rft.aulast=Mooney&rft.aufirst=Margaret&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Cancer+Symposium+of+the+Society+of+Surgical+Oncology+%28SSO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.surgonc.org/pdf/SSO_06_Prelim_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor Receptor 3 Related Craniosynostosis (Muenke Syndrome): A Further Description of Phenotype T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39946230; 4150599 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Doherty, Emily AU - Lacbawan, Felicitas AU - Rosenbaum, Kenneth AU - Hadley, Donald AU - Domingo, Demetrio AU - Hart, Thomas AU - Brewer, Carmen AU - Zalewski, Christopher AU - Kim, H AU - Solomon, Beth AU - Glass, Penny AU - Brooks, Brian AU - Immken, LaDonna AU - Kimonis, Virginia AU - Knightly, Carol AU - McDonald-McGinn, Donna AU - Zackai, Elaine AU - Muenke, Maximilian Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Craniosynostosis KW - Fibroblast growth factor receptor 3 KW - Phenotypes KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Fibroblast+Growth+Factor+Receptor+3+Related+Craniosynostosis+%28Muenke+Syndrome%29%3A+A+Further+Description+of+Phenotype&rft.au=Doherty%2C+Emily%3BLacbawan%2C+Felicitas%3BRosenbaum%2C+Kenneth%3BHadley%2C+Donald%3BDomingo%2C+Demetrio%3BHart%2C+Thomas%3BBrewer%2C+Carmen%3BZalewski%2C+Christopher%3BKim%2C+H%3BSolomon%2C+Beth%3BGlass%2C+Penny%3BBrooks%2C+Brian%3BImmken%2C+LaDonna%3BKimonis%2C+Virginia%3BKnightly%2C+Carol%3BMcDonald-McGinn%2C+Donna%3BZackai%2C+Elaine%3BMuenke%2C+Maximilian&rft.aulast=Doherty&rft.aufirst=Emily&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self-Assembly of the Influenza Hemagglutinin in the Plasma Membrane T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39935635; 4141908 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Zimmerberg, Joshua Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Plasma membranes KW - Self-assembly KW - Hemagglutinins KW - Influenza UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=Self-Assembly+of+the+Influenza+Hemagglutinin+in+the+Plasma+Membrane&rft.au=Zimmerberg%2C+Joshua&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Glycine Substitutions in the Amino end of Type I Collagen by Biochemical Screening of Fibroblast Collagen Requires Supplementation by Direct Sequencing for Osteogenesis Imperfecta Probands T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39914914; 4150538 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Cabral, Wayne AU - Milgrom, Sarah AU - Letocha, Anne AU - Moriarty, Emily AU - Marini, Joan Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Fibroblasts KW - Glycine KW - Collagen (type I) KW - Supplementation KW - Osteogenesis imperfecta KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39914914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=A+Novel+Functional+Group+of+Thalidomide+Analogues+Selectively+Kill+Leukemic+Cells&rft.au=Ge%2C+Yun%3BMontano%2C+Idalia%3BFreebern%2C+Wendy+J%3BHaggerty%2C+Cynthia+M%3BCui%2C+Wenwu%3BPonciano-Jackson%2C+Damaris%3BChandramouli%2C+G+V+R%3BLepper%2C+Erin%3BFigg%2C+William+D%3BJackson%2C+Sharon+H%3BGardner%2C+Kevin&rft.aulast=Ge&rft.aufirst=Yun&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Antigen-Induced Association of the B Cell Receptor with Lipid Rafts Visualized in Living Cells by FRET T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39897381; 4141896 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Pierce, Susan K Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Lipid rafts KW - Lymphocytes B KW - Fluorescence resonance energy transfer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=The+Antigen-Induced+Association+of+the+B+Cell+Receptor+with+Lipid+Rafts+Visualized+in+Living+Cells+by+FRET&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consortium for Osteogenesis Imperfecta Mutations: Lethal Regions in the Helical Portion of Type I Collagen Chains Align with Collagen Binding Sites for Integrin and Proteoglycans T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39875098; 4150756 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Marini, Joan AU - Forlino, Antonella AU - Cabral, Wayne AU - Barnes, Aileen AU - San Antonio, James AU - Milgrom, Sarah AU - Hyland, James AU - Korkko, Jarmo AU - Prockop, Darwin AU - DePaepe, Anne AU - Coucke, Paul AU - Glorieux, Francis AU - Roughley, Peter AU - Lund, Allan AU - Kuurila, Kaija AU - Cohn, Dan AU - Krakow, Deborah AU - Mottes, Monica AU - Dalgleish, Raymond AU - Byers, Peter Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Mutation KW - Collagen (type I) KW - Osteogenesis imperfecta KW - Proteoglycans KW - Integrins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Consortium+for+Osteogenesis+Imperfecta+Mutations%3A+Lethal+Regions+in+the+Helical+Portion+of+Type+I+Collagen+Chains+Align+with+Collagen+Binding+Sites+for+Integrin+and+Proteoglycans&rft.au=Marini%2C+Joan%3BForlino%2C+Antonella%3BCabral%2C+Wayne%3BBarnes%2C+Aileen%3BSan+Antonio%2C+James%3BMilgrom%2C+Sarah%3BHyland%2C+James%3BKorkko%2C+Jarmo%3BProckop%2C+Darwin%3BDePaepe%2C+Anne%3BCoucke%2C+Paul%3BGlorieux%2C+Francis%3BRoughley%2C+Peter%3BLund%2C+Allan%3BKuurila%2C+Kaija%3BCohn%2C+Dan%3BKrakow%2C+Deborah%3BMottes%2C+Monica%3BDalgleish%2C+Raymond%3BByers%2C+Peter&rft.aulast=Marini&rft.aufirst=Joan&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Breakpoint-Phenotype Analysis and Stereophotogrammetry of Chromosome 2q37 Deletion Syndrome T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39874470; 4150612 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Lacbawan, Felicitas AU - Domingo, Demetrio AU - Jones, Marypat AU - Hart, Thomas AU - Chandrasekharappa, Settara AU - Doherty, Emily Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Chromosome deletion KW - Chromosome 2 KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=Molecular+Breakpoint-Phenotype+Analysis+and+Stereophotogrammetry+of+Chromosome+2q37+Deletion+Syndrome&rft.au=Lacbawan%2C+Felicitas%3BDomingo%2C+Demetrio%3BJones%2C+Marypat%3BHart%2C+Thomas%3BChandrasekharappa%2C+Settara%3BDoherty%2C+Emily&rft.aulast=Lacbawan&rft.aufirst=Felicitas&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The National Ophthalmic Disease Genotyping Network (EyeGENE) T2 - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AN - 39869971; 4150779 JF - 2006 Annual Clinical Genetics Meeting (ACMG 2006) AU - Smaoui, Nizar AU - Tumminia, Santa AU - Blain, Delphine AU - Chin, Hemin AU - Sieving, Paul AU - Brooks, Brian Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Genotyping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.atitle=The+National+Ophthalmic+Disease+Genotyping+Network+%28EyeGENE%29&rft.au=Smaoui%2C+Nizar%3BTumminia%2C+Santa%3BBlain%2C+Delphine%3BChin%2C+Hemin%3BSieving%2C+Paul%3BBrooks%2C+Brian&rft.aulast=Smaoui&rft.aufirst=Nizar&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Clinical+Genetics+Meeting+%28ACMG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/ACMG/Browse.aspx?colID=-1&defID=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Disruption of the Deubiquitinating Enzyme CYLD Causes Heightened Mucosal Inflammation and Tumorigenesis T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39853454; 4141916 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Zhang, Jun Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Enzymes KW - Tumorigenesis KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39853454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Genetic+Disruption+of+the+Deubiquitinating+Enzyme+CYLD+Causes+Heightened+Mucosal+Inflammation+and+Tumorigenesis&rft.au=Zhang%2C+Jun&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Lipid Microdomains in HIV-1 Replication T2 - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AN - 39853375; 4141907 JF - 2006 Keystone Symposia on Lipid Rafts and Cell Function (D2) AU - Freed, Eric O Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Lipid rafts KW - Replication KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39853375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lipid+Rafts+and+Cell+Function+%28D2%29&rft.atitle=Role+of+Lipid+Microdomains+in+HIV-1+Replication&rft.au=Freed%2C+Eric+O&rft.aulast=Freed&rft.aufirst=Eric&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and TP53 Status T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39842478; 4141934 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Chen, Zhong Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - P53 protein KW - Squamous cell carcinoma KW - Head and neck cancer KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Molecular+Profiling+Distinguishes+Head+and+Neck+Squamous+Cell+Carcinomas+Expressing+Novel+Gene+Signatures+Related+to+NF-kappaB+and+TP53+Status&rft.au=Chen%2C+Zhong&rft.aulast=Chen&rft.aufirst=Zhong&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39839402; 4141947 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Van Waes, Carter Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Squamous cell carcinoma KW - P53 protein KW - Proteasomes KW - Head and neck cancer KW - IKK protein KW - Tumors KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=The+Proteasome%2C+IKK%2C+and+p53+in+Activation+of+NF-kappaB+and+Therapy+of+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Van+Waes%2C+Carter&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer T2 - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AN - 39783608; 4141963 JF - 2006 Keystone Symposia on NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3) AU - Staudt, Louis M Y1 - 2006/03/23/ PY - 2006 DA - 2006 Mar 23 KW - Cancer KW - RNA-mediated interference KW - Genetic screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39783608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.atitle=Genetic+Screens+with+an+RNA+Interference+Library+to+Identify+New+Molecular+Targets+in+Cancer&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2006-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+NF-kappaB%3A+20+Years+on+the+Road+from+Biochemistry+to+Pathology+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=811 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction between Secretory Leukocyte Protease Inhibitor (SLPI) and Granulin-Epithelin Precursor (prgn) is Necessary for Proliferation and Survival in Ovarian Cancer T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 40025523; 4196366 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Simpkins, Fiona AU - Kamrava, Mitchell AU - Devoogdt, Nick AU - Tchabo, Nana AU - Alejandro, Emilyn AU - Kohn, Elise C Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovarian cancer KW - Proteinase inhibitors KW - Leukocytes KW - Cell survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40025523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=HIV+Protease+Inhibitors+as+Cancer+Therapeutics%3A+Is+Off-The-Shelf+Right+on+Target%3F&rft.au=Gills%2C+Joell+J%3BLopiccolo%2C+Jaclyn%3BAbu-Asab%2C+Mones+S%3BShoemaker%2C+Robert%3BBorojerdi%2C+Jennifer%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profiling of Mucinous Tumors of the Ovary Identifies Genes of Clinicopathologic Importance T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 40020837; 4196286 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Wamunyokoli, Fred W AU - Bonome, Tomas AU - Lee, Ji-Young AU - Feltmate, Colleen M AU - Welch, William R AU - Radonovich, Mike AU - Pise-Masison, Cindy AU - Brady, John AU - Hao, Ke AU - Berkowitz, Ross S AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovaries KW - Tumors KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40020837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Molecular+Network+Profiling+of+Multiple+Myeloma+Bone+Marrow+Aspirates+Using+Reverse+Phase+Protein+Microarrays&rft.au=Sheehan%2C+Katherine+M%3BBurington%2C+Bart%3BRasmussen%2C+Erik%3BCrowley%2C+John%3BHuang%2C+Yongsheng%3BTricot%2C+Guido%3BBarlogie%2C+Bart%3BShaughnessy+Jr%2C+John+D%3BGulmann%2C+Christian%3BKay%2C+Elaine+W%3BWulfkuhle%2C+Julia+D%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Sheehan&rft.aufirst=Katherine&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Gene Expression Signature able to Predict for Survival in Patients with High-Grade Late-Stage Serous Ovarian Cancer: Identification of a Prognostic Gene Implicated in Angiogenesis T2 - 2006 Annual Meeting on Women's Cancer@@uTM@ AN - 39952238; 4196084 JF - 2006 Annual Meeting on Women's Cancer@@uTM@ AU - Bonome, Tomas AU - Park, Dong-Choon AU - Hao, Ke AU - Donninger, Howard AU - Bell, Aaron AU - Brady, John AU - Radonovich, Mike AU - Barrett, J Carl AU - Koon, Colin E AU - Wong, Wing H AU - Lee, Ji-Young AU - Welch, William R AU - Berkowitz, Ross S AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2006/03/22/ PY - 2006 DA - 2006 Mar 22 KW - Ovarian cancer KW - Angiogenesis KW - Survival KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+on+Women%27s+Cancer%40%40uTM%40&rft.atitle=Characterization+of+a+Gene+Expression+Signature+able+to+Predict+for+Survival+in+Patients+with+High-Grade+Late-Stage+Serous+Ovarian+Cancer%3A+Identification+of+a+Prognostic+Gene+Implicated+in+Angiogenesis&rft.au=Bonome%2C+Tomas%3BPark%2C+Dong-Choon%3BHao%2C+Ke%3BDonninger%2C+Howard%3BBell%2C+Aaron%3BBrady%2C+John%3BRadonovich%2C+Mike%3BBarrett%2C+J+Carl%3BKoon%2C+Colin+E%3BWong%2C+Wing+H%3BLee%2C+Ji-Young%3BWelch%2C+William+R%3BBerkowitz%2C+Ross+S%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Bonome&rft.aufirst=Tomas&rft.date=2006-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+on+Women%27s+Cancer%40%40uTM%40&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7BFB92C837%2 D401D%2D4EE4%2D8CD3%2DB843E2E1E5B9%7D&AKey=%7BB7907D10%2DF8DC%2D4B3E %2D9A2D%2D09190825CF75%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. AN - 67773734; 16537416 AB - Free radical formation has been investigated in diverse experimental models of LPS-induced inflammation. Here, using electron spin resonance (ESR) and the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone, we have detected an ESR spectrum of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in the lipid extract of mouse skin treated with LPS for 6 h. The ESR spectrum was consistent with the trapping of lipid-derived radical adducts. In addition, a secondary radical-trapping technique using dimethyl sulfoxide (DMSO) demonstrated methyl radical formation, revealing the production of hydroxyl radical. Radical adduct formation was suppressed by aminoguanidine, N-(3-aminomethyl)benzylacetamidine (1400W), or allopurinol, suggesting a role for both inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO) in free radical formation. The radical formation was also suppressed in iNOS knockout (iNOS(-/-)) mice, demonstrating the involvement of iNOS. NADPH oxidase was not required in the formation of these radical adducts because the ESR signal intensity was increased by LPS treatment in NADPH oxidase knockout (gp91(phox-/-)) mice as much as it was in the wild-type mouse. Nitric oxide (*NO) end products were increased in LPS-treated skin. As expected, the *NO end products were not suppressed by allopurinol but were by aminoguanidine. Interestingly, nitrotyrosine formation in LPS-treated skin was also suppressed by aminoguanidine and allopurinol independently. Pretreatment with the ferric iron chelator Desferal had no effect on free radical formation. Our results imply that both iNOS and XO, but neither NADPH oxidase nor ferric iron, work synergistically to form lipid radical and nitrotyrosine early in the skin inflammation caused by LPS. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Nakai, Kozo AU - Kadiiska, Maria B AU - Jiang, Jin-Jie AU - Stadler, Krisztian AU - Mason, Ronald P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, MD F0-01, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 SP - 4616 EP - 4621 VL - 103 IS - 12 SN - 0027-8424, 0027-8424 KW - Enzyme Inhibitors KW - 0 KW - Free Radicals KW - Guanidines KW - Lipopolysaccharides KW - Allopurinol KW - 63CZ7GJN5I KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Xanthine Oxidase KW - EC 1.17.3.2 KW - pimagedine KW - SCQ4EZQ113 KW - Index Medicus KW - Animals KW - Allopurinol -- pharmacology KW - Electron Spin Resonance Spectroscopy KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Mice KW - Guanidines -- pharmacology KW - Xanthine Oxidase -- metabolism KW - Xanthine Oxidase -- antagonists & inhibitors KW - Skin -- enzymology KW - Skin -- drug effects KW - Skin -- metabolism KW - Nitric Oxide Synthase Type II -- antagonists & inhibitors KW - Lipopolysaccharides -- toxicity KW - Nitric Oxide Synthase Type II -- metabolism KW - Dermatitis -- enzymology KW - Free Radicals -- metabolism KW - Dermatitis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67773734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Determinants+of+Cancer+Disparities%3A+Barriers+to+Cancer+Screening%2C+Diagnosis%2C+and+Treatment&rft.au=Chu%2C+Kenneth+C&rft.aulast=Chu&rft.aufirst=Kenneth&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1994 Apr;310(1):118-25 [8161194] J Clin Invest. 1989 Apr;83(4):1137-43 [2539390] Nature. 1995 Jun 1;375(6530):408-11 [7539113] J Invest Dermatol. 1996 Jan;106(1):113-8 [8592060] Biochem Pharmacol. 1996 Jun 28;51(12):1727-38 [8687488] Chem Res Toxicol. 1996 Jul-Aug;9(5):845-50 [8828919] J Exp Med. 1996 Nov 1;184(5):2007-12 [8920887] Br J Dermatol. 1997 Jan;136(1):18-23 [9039289] J Clin Invest. 1997 Feb 15;99(4):635-42 [9045865] Chem Res Toxicol. 1997 Oct;10(10):1104-8 [9348432] J Clin Invest. 1998 Mar 1;101(5):967-71 [9486966] Br J Pharmacol. 1998 Apr;123(7):1325-30 [9579726] J Invest Dermatol. 1998 Jul;111(1):149-53 [9665402] Cancer Res. 1998 Nov 1;58(21):4832-9 [9809987] J Biol Chem. 1999 Apr 16;274(16):10689-92 [10196138] J Biol Chem. 1999 Apr 16;274(16):10802-6 [10196155] Free Radic Biol Med. 2005 Jan 1;38(1):125-35 [15589381] Am J Respir Crit Care Med. 2005 Feb 15;171(4):379-87 [15477498] Free Radic Biol Med. 2005 Oct 15;39(8):1050-8 [16198232] Curr Opin Microbiol. 2000 Feb;3(1):23-8 [10679425] Br J Pharmacol. 2000 May;130(1):90-4 [10781002] Nature. 2000 Aug 17;406(6797):782-7 [10963608] Chem Res Toxicol. 2001 Sep;14(9):1273-6 [11559043] Nat Rev Immunol. 2001 Nov;1(2):135-45 [11905821] J Trauma. 2002 Apr;52(4):683-7 [11956382] Nature. 2002 Sep 5;419(6902):77-81 [12214235] FASEB J. 2002 Nov;16(13):1713-20 [12409313] Pharmacol Res. 2002 Dec;46(6):557-64 [12457631] J Ethnopharmacol. 2003 Mar;85(1):33-41 [12576200] FASEB J. 2003 Apr;17(6):636-43 [12665476] Redox Rep. 2003;8(2):105-12 [12804013] FEBS Lett. 2004 Mar 26;562(1-3):129-33 [15044013] J Invest Dermatol. 2004 Apr;122(4):1000-9 [15102091] Diabetes. 2004 May;53(5):1344-51 [15111505] Spectrochim Acta A Mol Biomol Spectrosc. 2004 May;60(6):1371-7 [15134737] Biochimie. 2004 Jul;86(7):425-9 [15308331] Infect Immun. 2004 Sep;72(9):4933-9 [15321984] Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Aug;32(2):195-202 [302250] J Biol Chem. 1981 Sep 10;256(17):9006-103 [6267059] Cancer Res. 1987 Apr 1;47(7):1775-9 [3469021] FEBS Lett. 1987 Mar 9;213(1):23-8 [3030809] J Magn Reson B. 1994 Jun;104(2):105-10 [8049862] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Autoimmunity and Impaired T Cell Apoptosis in Wiskott-Aldrich Syndrome Protein Deficiency: A FasL Connection T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 40003814; 4143105 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Nikolov, Nikolay P Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - FasL protein KW - Protein deficiency KW - Apoptosis KW - Wiskott-Aldrich syndrome KW - Lymphocytes T KW - Autoimmunity KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Autoimmunity+and+Impaired+T+Cell+Apoptosis+in+Wiskott-Aldrich+Syndrome+Protein+Deficiency%3A+A+FasL+Connection&rft.au=Nikolov%2C+Nikolay+P&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Distinct Subset of MHC-Independent FoxP3+ T Cells Participates in the Control of Adaptive Immune Responses In Vivo T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39949670; 4143059 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Stephens, Geoffrey L Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes T UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39949670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Human+Keratin+14+Expression+in+Mouse+Lung+Induces+Early+Squamous+Differentiation&rft.au=Dakir%2C+El+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=El&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstitution of Lymphopenic Mice with Limited T-Cell Repertoire Results in Severe Multiorgan Eosinophilic Disease T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39921172; 4143080 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Milner, Joshua D Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Mice KW - Lymphocytes T KW - Lymphopenia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Reconstitution+of+Lymphopenic+Mice+with+Limited+T-Cell+Repertoire+Results+in+Severe+Multiorgan+Eosinophilic+Disease&rft.au=Milner%2C+Joshua+D&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Expression of IRBP is Dispensable for Generation of CD4+CD25+ Regulatory T Cells that Protect Against IRBP-Induced Experimental Autoimmune Uveitis (EAU) T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39921107; 4143062 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Grajewski, Rafael S Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Experimental autoimmune uveitis KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Endogenous+Expression+of+IRBP+is+Dispensable+for+Generation+of+CD4%2BCD25%2B+Regulatory+T+Cells+that+Protect+Against+IRBP-Induced+Experimental+Autoimmune+Uveitis+%28EAU%29&rft.au=Grajewski%2C+Rafael+S&rft.aulast=Grajewski&rft.aufirst=Rafael&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of Pathogenic and Regulatory T Cells in a Model of Retinal Autoimmunity: Dependency on Innate Immune Responses T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913799; 4143074 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Caspi, Rachel R Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes T KW - Immunoregulation KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Generation+of+Pathogenic+and+Regulatory+T+Cells+in+a+Model+of+Retinal+Autoimmunity%3A+Dependency+on+Innate+Immune+Responses&rft.au=Caspi%2C+Rachel+R&rft.aulast=Caspi&rft.aufirst=Rachel&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR7/8 Gene Duplication in the Pseudoautosomal Region of Y-Linked Autoimmune Accelerating (Yaa) Mice T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913733; 4143068 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Bolland, Silvia Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Mice KW - Gene duplication KW - Toll-like receptors KW - TLR7 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Bisindolylmaleimide+and+Indolocarbazole+Protein+Kinase+%28PK%29+Inhibitors+Reverse+ABCG2-Mediated+Drug+Transport+and+Resistance&rft.au=Robey%2C+Robert+W%3BShukla%2C+Suneet%3BSteadman%2C+Kenneth%3BAmbudkar%2C+Suresh+V%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C-Abl Family Kinases Mediate Apoptosis in B Cells in Response to Fc Receptor Stimulation T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39913684; 4143054 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - Tzeng, Shiang-Jong Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Lymphocytes B KW - Apoptosis KW - Fc receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=C-Abl+Family+Kinases+Mediate+Apoptosis+in+B+Cells+in+Response+to+Fc+Receptor+Stimulation&rft.au=Tzeng%2C+Shiang-Jong&rft.aulast=Tzeng&rft.aufirst=Shiang-Jong&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polyclonal and Organ Specific CD4+CD25+Foxp3+ Regulatory T Cells (nTregs): Different Mechanisms of Suppressing Organ Specific Autoimmunity In Vivo T2 - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AN - 39839852; 4143108 JF - 2006 Keystone Symposia on Tolerance, Autoimmunity and Immune Regulation (D1) AU - DiPaolo, Rich J Y1 - 2006/03/21/ PY - 2006 DA - 2006 Mar 21 KW - Organs KW - Lymphocytes T KW - Immunoregulation KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.atitle=Polyclonal+and+Organ+Specific+CD4%2BCD25%2BFoxp3%2B+Regulatory+T+Cells+%28nTregs%29%3A+Different+Mechanisms+of+Suppressing+Organ+Specific+Autoimmunity+In+Vivo&rft.au=DiPaolo%2C+Rich+J&rft.aulast=DiPaolo&rft.aufirst=Rich&rft.date=2006-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Tolerance%2C+Autoimmunity+and+Immune+Regulation+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=799&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Sequence: Different Types of HIV-1 Strains are Likely to have been Introduced from Neighboring Countries to Mali. T2 - 6th Congress of the Federation of African Immunological Societies AN - 40116605; 4257138 JF - 6th Congress of the Federation of African Immunological Societies AU - Koita, Ousmane A AU - Cisse, Aissata B AU - Dao, Sounkalo AU - Sogoba, Dramane AU - Ibrah, Mahamadou AU - Dabitao, Djeneba AU - Traore, Abdel Kader AU - Tounkara, Anatole AU - Imamichi, Hiromi Y1 - 2006/03/20/ PY - 2006 DA - 2006 Mar 20 KW - Mali KW - Strains KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Congress+of+the+Federation+of+African+Immunological+Societies&rft.atitle=HIV-1+Sequence%3A+Different+Types+of+HIV-1+Strains+are+Likely+to+have+been+Introduced+from+Neighboring+Countries+to+Mali.&rft.au=Koita%2C+Ousmane+A%3BCisse%2C+Aissata+B%3BDao%2C+Sounkalo%3BSogoba%2C+Dramane%3BIbrah%2C+Mahamadou%3BDabitao%2C+Djeneba%3BTraore%2C+Abdel+Kader%3BTounkara%2C+Anatole%3BImamichi%2C+Hiromi&rft.aulast=Koita&rft.aufirst=Ousmane&rft.date=2006-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Congress+of+the+Federation+of+African+Immunological+Societies&rft.issn=&rft_id=info:doi/ L2 - http://www.faisoc.org/English/Conferences/6_Dakar/Dakar.Htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Actions Addressing the Obesity Epidemic and Research Directions for the Future T2 - 2nd National Conference on Obesity and Health AN - 39933517; 4204698 JF - 2nd National Conference on Obesity and Health AU - Hubbard, Van S Y1 - 2006/03/20/ PY - 2006 DA - 2006 Mar 20 KW - Obesity KW - Epidemics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+National+Conference+on+Obesity+and+Health&rft.atitle=National+Actions+Addressing+the+Obesity+Epidemic+and+Research+Directions+for+the+Future&rft.au=Hubbard%2C+Van+S&rft.aulast=Hubbard&rft.aufirst=Van&rft.date=2006-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+National+Conference+on+Obesity+and+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.obesityandhealth.co.uk/programme_2006.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-Inflammatory Actions T2 - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AN - 40005946; 4141862 JF - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AU - Cidlowski, John A Y1 - 2006/03/18/ PY - 2006 DA - 2006 Mar 18 KW - Translation KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Nucleotide+Damage+Proximal+to+DNA+Double-Strand+Break+ends+is+a+Stronger+Inhibitor+of+Non-Homologous+end+Joining+than+Blocked+3+Ends&rft.au=Datta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Datta&rft.aufirst=Kamal&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=815 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Physiological Gene Responsiveness in ERKO Mice T2 - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AN - 39847905; 4141827 JF - 2006 Keystone Symposia on Nuclear Receptors: Steroid Sisters (X4) AU - Korach, Kenneth S Y1 - 2006/03/18/ PY - 2006 DA - 2006 Mar 18 KW - Mice KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39847905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28X4%29&rft.atitle=Differential+Physiological+Gene+Responsiveness+in+ERKO+Mice&rft.au=Korach%2C+Kenneth+S&rft.aulast=Korach&rft.aufirst=Kenneth&rft.date=2006-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=815 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Astrocytes promote myelination in response to electrical impulses. AN - 67764440; 16543131 AB - Myelin, the insulating layers of membrane wrapped around axons by oligodendrocytes, is essential for normal impulse conduction. It forms during late stages of fetal development but continues into early adult life. Myelination correlates with cognitive development and can be regulated by impulse activity through unknown molecular mechanisms. Astrocytes do not form myelin, but these nonneuronal cells can promote myelination in ways that are not understood. Here, we identify a link between myelination, astrocytes, and electrical impulse activity in axons that is mediated by the cytokine leukemia inhibitory factor (LIF). These findings show that LIF is released by astrocytes in response to ATP liberated from axons firing action potentials, and LIF promotes myelination by mature oligodendrocytes. This activity-dependent mechanism promoting myelination could regulate myelination according to functional activity or environmental experience and may offer new approaches to treating demyelinating diseases. JF - Neuron AU - Ishibashi, Tomoko AU - Dakin, Kelly A AU - Stevens, Beth AU - Lee, Philip R AU - Kozlov, Serguei V AU - Stewart, Colin L AU - Fields, R Douglas AD - Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. Y1 - 2006/03/16/ PY - 2006 DA - 2006 Mar 16 SP - 823 EP - 832 VL - 49 IS - 6 SN - 0896-6273, 0896-6273 KW - Anesthetics, Local KW - 0 KW - Antibodies KW - Azo Compounds KW - Bearded protein, Drosophila KW - DNA-Binding Proteins KW - Drosophila Proteins KW - Interleukin-6 KW - Leukemia Inhibitory Factor KW - Lif protein, mouse KW - MOG protein, human KW - Mog protein, mouse KW - Mog protein, rat KW - Myelin Basic Protein KW - Myelin Proteins KW - Myelin-Associated Glycoprotein KW - Myelin-Oligodendrocyte Glycoprotein KW - Naphthalenes KW - O Antigens KW - RNA, Messenger KW - Thionucleotides KW - Adenosine-5'-(N-ethylcarboxamide) KW - 35920-39-9 KW - 2-methylthio-ATP KW - 43170-89-4 KW - Tetrodotoxin KW - 4368-28-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Sudan Black B KW - 9YDL1Q990E KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Gene Expression -- drug effects KW - Axons -- radiation effects KW - Animals KW - Cerebral Cortex -- cytology KW - Drug Interactions KW - Neurons -- drug effects KW - Adenosine-5'-(N-ethylcarboxamide) -- pharmacology KW - Blotting, Western -- methods KW - Models, Biological KW - RNA, Messenger -- biosynthesis KW - Rats KW - Antibodies -- pharmacology KW - Adenosine Triphosphate -- analogs & derivatives KW - Neurons -- physiology KW - Myelin Basic Protein -- metabolism KW - Interleukin-6 -- immunology KW - Stem Cells KW - Time Factors KW - Drosophila Proteins -- metabolism KW - Embryo, Mammalian KW - DNA-Binding Proteins -- metabolism KW - Action Potentials -- physiology KW - Axons -- drug effects KW - Anesthetics, Local -- pharmacology KW - Coculture Techniques -- methods KW - Action Potentials -- radiation effects KW - Dose-Response Relationship, Drug KW - Interleukin-6 -- metabolism KW - Mice KW - Immunohistochemistry -- methods KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Ganglia, Spinal -- cytology KW - Thionucleotides -- pharmacology KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Adenosine -- pharmacology KW - Axons -- metabolism KW - O Antigens -- metabolism KW - Cell Count -- methods KW - Cells, Cultured KW - Neurons -- cytology KW - Adenosine Triphosphate -- metabolism KW - Myelin-Associated Glycoprotein -- metabolism KW - Tetrodotoxin -- pharmacology KW - Adenosine Triphosphate -- pharmacology KW - Cell Communication -- radiation effects KW - Electric Stimulation -- methods KW - Cell Communication -- drug effects KW - Astrocytes -- physiology KW - Cell Communication -- physiology KW - Astrocytes -- radiation effects KW - Myelin Proteins -- metabolism KW - Oligodendroglia -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67764440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.atitle=Induction+of+DLC-1+Tumor+Suppressor+Gene+Expression+in+Breast+Cancer+Cells+by+Proapoptotic+Dietary+Flavone+and+its+Potential+Implication+in+Chemoprevetion&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicolae+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+the+American+Association+for+the+Cancer+Research+%28AACR+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1993 Jan 21;361(6409):258-60 [8093806] Nature. 1992 Sep 3;359(6390):76-9 [1522892] Development. 1989 May;106(1):119-32 [2697546] J Neuroimmunol. 1989 May;22(3):169-76 [2649509] Ann N Y Acad Sci. 2004 Jun;1021:77-85 [15251877] Curr Top Med Chem. 2004;4(8):793-803 [15078211] Sci Am. 2004 Apr;290(4):54-61 [15045754] Neuron. 2002 Dec 5;36(5):855-68 [12467589] J Neurosci. 2002 Nov 1;22(21):9221-7 [12417647] Development. 1994 Jan;120(1):143-53 [8119123] Cell Tissue Res. 2002 Nov;310(2):155-61 [12397370] Science. 2002 Oct 18;298(5593):556-62 [12386325] Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):391-4 [12175878] Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):259-68 [12175861] J Neuroimmunol. 2002 Aug;129(1-2):43-50 [12161019] Nat Med. 2002 Jun;8(6):613-9 [12042813] Dev Neurosci. 2001;23(4-5):327-37 [11756748] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7109-13 [8041754] Science. 1995 Nov 24;270(5240):1369-72 [7481827] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9887-92 [8790426] Neuron. 1996 Oct;17(4):607-15 [8893019] J Neurobiol. 1998 Sep 15;36(4):509-24 [9740023] J Neurosci. 1998 Nov 15;18(22):9303-11 [9801369] Folia Neuropathol. 1999;37(2):81-6 [10464425] Nat Neurosci. 2005 Sep;8(9):1148-50 [16116456] Hum Brain Mapp. 2005 Oct;26(2):139-47 [15858815] Neuroscientist. 2005 Dec;11(6):528-31 [16282593] Mol Cell Neurosci. 1999 Oct-Nov;14(4-5):385-97 [10588392] Science. 2000 Mar 24;287(5461):2267-71 [10731149] Trends Neurosci. 2000 Dec;23(12):625-33 [11137153] Comment In: Neuron. 2006 Mar 16;49(6):777-8 [16543121] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886. AN - 67773084; 16551867 AB - The small molecular inhibitor MK886 is known to block 5-lipoxygenase-activating protein ALOX5AP and shows antitumor activity in multiple human cell lines. The broad antitumor therapeutic window reported in vivo for MK886 in rodents supports further consideration of this structural class. Better understanding of the mode of action of the drug is important for application in humans to take place. Affymetrix microarray study was conducted to explore MK886 pharmacologic mechanism. Ingenuity Pathway Analysis software was applied to validate the results at the transcriptional level by putting them in the context of an experimental proteomic network. Genes most affected by MK886 included actin B and focal adhesion components. A subsequent National Cancer Institute-60 panel study, RT-PCR validation followed by confocal microscopy, and Western blotting also pointed to actin B down-regulation, filamentous actin loss, and disorganization of the transcription machinery. In agreement with these observations, MK886 was found to enhance the effect of UV radiation in H720 lung cancer cell line. In light of the modification of cytoskeleton and cell motility by lipid phosphoinositide 3-kinase products, MK886 interaction with actin B might be biologically important. The low toxicity of MK886 in vivo was modeled and explained by binding and transport by dietary lipids. The rate of lipid absorbance is generally higher for tumors, suggesting a promise of a targeted liposome-based delivery system for this drug. These results suggest a novel antitumor pharmacologic mechanism. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Mayburd, Anatoly L AU - Martlínez, Alfredo AU - Sackett, Daniel AU - Liu, Huaitian AU - Shih, Joanna AU - Tauler, Jordy AU - Avis, Ingalill AU - Mulshine, James L AD - Intervention Section, National Cancer Institute, NIH, Bethesda, MD 20859, USA. mayburna@mail.nih.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 1820 EP - 1827 VL - 12 IS - 6 SN - 1078-0432, 1078-0432 KW - Actins KW - 0 KW - Indoles KW - Lipoxygenase Inhibitors KW - MK-886 KW - 080626SQ8C KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Cytoskeleton -- metabolism KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - Actins -- metabolism KW - Cell Line, Tumor KW - Signal Transduction -- radiation effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Cytoskeleton -- drug effects KW - Blotting, Western KW - Actins -- genetics KW - Lipoxygenase Inhibitors -- pharmacology KW - Signal Transduction -- drug effects KW - Signal Transduction -- genetics KW - Gene Expression Regulation, Neoplastic -- radiation effects KW - Cytoskeleton -- radiation effects KW - Gene Expression Profiling KW - Transcription, Genetic -- drug effects KW - Transcription, Genetic -- radiation effects KW - Indoles -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67773084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Ingenuity+network-assisted+transcription+profiling%3A+Identification+of+a+new+pharmacologic+mechanism+for+MK886.&rft.au=Mayburd%2C+Anatoly+L%3BMartl%C3%ADnez%2C+Alfredo%3BSackett%2C+Daniel%3BLiu%2C+Huaitian%3BShih%2C+Joanna%3BTauler%2C+Jordy%3BAvis%2C+Ingalill%3BMulshine%2C+James+L&rft.aulast=Mayburd&rft.aufirst=Anatoly&rft.date=2006-03-15&rft.volume=12&rft.issue=6&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pooled analysis of second primary pancreatic cancer. AN - 67717857; 16421239 AB - Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries with a registration period up to year 2000. Cancer patients were followed up from the initial cancer diagnosis, and the occurrence of second primary malignant neoplasms was compared with expected values derived from local rates, adjusting for age, sex, and period of diagnosis. Results from individual registries were pooled by use of a fixed-effects model. People were at higher risk of developing pancreatic cancer within 10 years of a diagnosis of cancers of the pharynx, stomach, gallbladder, larynx, lung, cervix, corpus uteri, bladder, and eye and 10 years or later following a diagnosis of cancers of the stomach, colon, gallbladder, breast, cervix, placenta, corpus uteri, ovary, testis, bladder, kidney, and eye, as well as Hodgkin's and non-Hodgkin's lymphomas. Pancreatic cancer was connected with smoking-related cancers, confirming the etiologic role of tobacco. The associations with uterine and ovarian cancers suggest that reproductive factors might be implicated in pancreatic carcinogenesis. The elevated pancreatic cancer risk in young patients observed among several types of cancer implies a role of genetic factors. Radiotherapy is also suggested as a risk factor. JF - American journal of epidemiology AU - Shen, Min AU - Boffetta, Paolo AU - Olsen, Jørgen H AU - Andersen, Aage AU - Hemminki, Kari AU - Pukkala, Eero AU - Tracey, Elizabeth AU - Brewster, David H AU - McBride, Mary L AU - Pompe-Kirn, Vera AU - Kliewer, Erich V AU - Tonita, Jon M AU - Chia, Kee-Seng AU - Martos, Carmen AU - Jonasson, Jon G AU - Colin, Didier AU - Scélo, Ghislaine AU - Brennan, Paul AD - International Agency for Research on Cancer, Lyon, France. shenmi@mail.nih.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 502 EP - 511 VL - 163 IS - 6 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Registries KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Neoplasms, Second Primary -- epidemiology KW - Smoking -- adverse effects KW - Pancreatic Neoplasms -- epidemiology KW - Risk Assessment KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67717857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=A+pooled+analysis+of+second+primary+pancreatic+cancer.&rft.au=Shen%2C+Min%3BBoffetta%2C+Paolo%3BOlsen%2C+J%C3%B8rgen+H%3BAndersen%2C+Aage%3BHemminki%2C+Kari%3BPukkala%2C+Eero%3BTracey%2C+Elizabeth%3BBrewster%2C+David+H%3BMcBride%2C+Mary+L%3BPompe-Kirn%2C+Vera%3BKliewer%2C+Erich+V%3BTonita%2C+Jon+M%3BChia%2C+Kee-Seng%3BMartos%2C+Carmen%3BJonasson%2C+Jon+G%3BColin%2C+Didier%3BSc%C3%A9lo%2C+Ghislaine%3BBrennan%2C+Paul&rft.aulast=Shen&rft.aufirst=Min&rft.date=2006-03-15&rft.volume=163&rft.issue=6&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. AN - 67702627; 16446309 AB - Smith-Lemli-Opitz syndrome (SLOS) is a genetic syndrome caused by mutations in the 3beta-hydroxysterol Delta(7)-reductase gene (DHCR7). SLOS patients have decreased cholesterol and increased 7-dehydrocholesterol (7-DHC) levels. Dietary cholesterol supplementation improves systemic biochemical abnormalities; however, because of the blood-brain barrier, the central nervous system (CNS) is not treated. Simvastatin therapy has been proposed as a means to treat the CNS. Mice homozygous for a null disruption of Dhcr7, Dhcr7(Delta3-5/Delta3-5), die soon after birth, thus they cannot be used to study postnatal development or therapy. To circumvent this problem, we produced a hypomorphic SLOS mouse model by introducing a mutation corresponding to DHCR7(T93M). Both Dhcr7(T93M/T93M) and Dhcr7(Delta3-5/T93M) mice are viable. Phenotypic findings in Dhcr7(T93M/Delta3-5) mice include CNS ventricular dilatation and two to three syndactyly. Biochemically, both Dhcr7(T93M/T93M) and Dhcr7(T93M/Delta3-5) mice have elevated tissue 7-DHC levels; however, the biochemical defect improved with age. This has not been observed in human patients, and is due to elevated Dhcr7 expression in mouse tissues. Dietary cholesterol therapy improved sterol profiles in peripheral, but not CNS tissues. However, treatment of Dhcr7(T93M/Delta3-5) mice with simvastatin decreased 7-DHC levels in both peripheral and brain tissues. Expression of Dhcr7 increased in Dhcr7(T93M/Delta3-5) tissues after simvastatin therapy, consistent with the hypothesis that simvastatin therapy improves the biochemical phenotype by increasing the expression of a Dhcr7 allele with residual enzymatic activity. We conclude that simvastatin treatment is efficacious in improving the SLOS-associated sterol abnormality found in the brain, and thus has the potential to be an effective therapeutic intervention for behavioral and learning problems associated with SLOS. JF - Human molecular genetics AU - Correa-Cerro, Lina S AU - Wassif, Christopher A AU - Kratz, Lisa AU - Miller, Georgina F AU - Munasinghe, Jeeva P AU - Grinberg, Alexander AU - Fliesler, Steven J AU - Porter, Forbes D AD - Unit on Molecular Dysmorphology, Heritable Disorders Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 839 EP - 851 VL - 15 IS - 6 SN - 0964-6906, 0964-6906 KW - Threonine KW - 2ZD004190S KW - Methionine KW - AE28F7PNPL KW - Simvastatin KW - AGG2FN16EV KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - 7-dehydrocholesterol reductase KW - EC 1.3.1.21 KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Threonine -- genetics KW - Mice KW - Magnetic Resonance Spectroscopy KW - Phenotype KW - Mutagenesis, Site-Directed KW - Methionine -- genetics KW - Alleles KW - Embryonic Stem Cells -- transplantation KW - Amino Acid Substitution -- genetics KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Female KW - Simvastatin -- therapeutic use KW - Smith-Lemli-Opitz Syndrome -- drug therapy KW - Disease Models, Animal KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Smith-Lemli-Opitz Syndrome -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67702627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Development+and+characterization+of+a+hypomorphic+Smith-Lemli-Opitz+syndrome+mouse+model+and+efficacy+of+simvastatin+therapy.&rft.au=Correa-Cerro%2C+Lina+S%3BWassif%2C+Christopher+A%3BKratz%2C+Lisa%3BMiller%2C+Georgina+F%3BMunasinghe%2C+Jeeva+P%3BGrinberg%2C+Alexander%3BFliesler%2C+Steven+J%3BPorter%2C+Forbes+D&rft.aulast=Correa-Cerro&rft.aufirst=Lina&rft.date=2006-03-15&rft.volume=15&rft.issue=6&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humans. AN - 67701092; 16144747 AB - The rate hypothesis of psychoactive drug action holds that the faster a drug reaches the brain and starts to act, the greater its reinforcing effects and abuse liability. A previous human study using a single cocaine dose confirmed the rate hypothesis for subjective responses, but found no rate effect on cardiovascular responses. We evaluated the rate hypothesis in 17 experienced cocaine users (7 [all men] provided complete data; 6 participated in only 1-2 sessions) by administering IV cocaine at each of three doses (10, 25, 50 mg) and injection durations (10, 30, 60 s) in a double-blind, placebo-controlled, escalating dose design. Heart rate, blood pressure, and positive (e.g., rush, high) and negative (e.g., feel bad, anxious) subjective effects (100-mm visual analogue scales) were measured for 1h after dosing. Peak change from baseline, time to peak, and area under the time-response curve were evaluated with repeated measures mixed linear regression analyses, allowing use of data from all sessions for all subjects, including non-completers. Both dose (mg) and infusion rate (mg/s) significantly influenced most subjective and cardiovascular variables. Analysis of the interaction suggested that dose had a stronger impact than rate. Rate had a stronger influence on positive subjective effects than on negative subjective effects or cardiovascular variables. These findings provide support for the rate hypothesis as it applies to both subjective and cardiovascular effects of IV cocaine administration in humans. JF - Drug and alcohol dependence AU - Nelson, Richard A AU - Boyd, Susan J AU - Ziegelstein, Roy C AU - Herning, Ronald AU - Cadet, Jean L AU - Henningfield, Jack E AU - Schuster, Charles R AU - Contoreggi, Carlo AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health & Human Services, Baltimore, MD 21224, USA. Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 19 EP - 24 VL - 82 IS - 1 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Electrocardiography KW - Electroencephalography KW - Adult KW - Male KW - Prevalence KW - Heart Rate -- drug effects KW - Anxiety -- chemically induced KW - Cocaine-Related Disorders -- physiopathology KW - Substance Abuse, Intravenous -- physiopathology KW - Substance Abuse, Intravenous -- epidemiology KW - Periodicity KW - Cocaine-Related Disorders -- epidemiology KW - Blood Pressure -- drug effects KW - Cocaine -- adverse effects KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67701092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Effect+of+rate+of+administration+on+subjective+and+physiological+effects+of+intravenous+cocaine+in+humans.&rft.au=Nelson%2C+Richard+A%3BBoyd%2C+Susan+J%3BZiegelstein%2C+Roy+C%3BHerning%2C+Ronald%3BCadet%2C+Jean+L%3BHenningfield%2C+Jack+E%3BSchuster%2C+Charles+R%3BContoreggi%2C+Carlo%3BGorelick%2C+David+A&rft.aulast=Nelson&rft.aufirst=Richard&rft.date=2006-03-15&rft.volume=82&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Borrelia burgdorferi Lipoprotein-Mediated TLR2 Stimulation Causes the Down-Regulation of TLR5 in Human Monocytes AN - 17092970; 6725963 AB - Toll-like receptors (TLRs) trigger innate immune responses via the recognition of conserved pathogen-associated molecular patterns. Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease, activate inflammatory cells through TLR2 and TLR1. We show that stimulation of human monocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipopeptide Pam sub(3)CysSerLys sub(4) results in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for bacterial flagellin, and that this effect is mediated via TLR2. TLR4 stimulation had no effect on TLR2, TLR1, and TLRS expression. Human monocytes stimulated with TLR5 ligands (including p37 or flaA, the minor protein from B. burgdorferi flagella) up-regulated TLR5. In addition, TLR2 stimulation rendered cells hyporesponsive to a TLR5 agonist. There results indicate that diverse stimuli can cause differential TLR expression, and we hypothesize that these changes may be useful for either the pathogen and/or the host. JF - Journal of Infectious Diseases AU - Cabral, E S AU - Gelderblom, H AU - Hornung, R L AU - Munson, P J AU - Martin, R AU - Marques, A R AD - ClinicaI Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, and Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 849 EP - 859 VL - 193 IS - 6 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Borrelia burgdorferi KW - TLR2 protein KW - TLR5 protein KW - Inflammatory diseases KW - outer surface protein A KW - Lipoproteins KW - Monocytes KW - lipopeptides KW - Flagellin KW - TLR4 protein KW - Toll-like receptors KW - Flagella KW - Lyme disease KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17092970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Borrelia+burgdorferi+Lipoprotein-Mediated+TLR2+Stimulation+Causes+the+Down-Regulation+of+TLR5+in+Human+Monocytes&rft.au=Cabral%2C+E+S%3BGelderblom%2C+H%3BHornung%2C+R+L%3BMunson%2C+P+J%3BMartin%2C+R%3BMarques%2C+A+R&rft.aulast=Cabral&rft.aufirst=E&rft.date=2006-03-15&rft.volume=193&rft.issue=6&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - outer surface protein A; Inflammatory diseases; TLR5 protein; Lipoproteins; TLR2 protein; Monocytes; lipopeptides; TLR4 protein; Flagellin; Toll-like receptors; Lyme disease; Flagella; Borrelia burgdorferi ER - TY - JOUR T1 - A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. AN - 67740976; 16481597 AB - Creatine and minocycline were prioritized for testing in Phase II clinical trials based on a systematic evaluation of potentially disease modifying compounds for Parkinson disease (PD). To test whether creatine and minocycline alter the course of early PD relative to a predetermined futility threshold for progression of PD in a randomized, double-blind, Phase II futility clinical trial. Agents that do not perform better than the futility threshold are rejected as futile and are not considered for further study. Participants had a diagnosis of PD within 5 years, but did not require medications for the management of symptoms. The primary outcome was the change in the total Unified Parkinson's Disease Rating Scale (UPDRS) score from baseline to either the time when there was sufficient disability to warrant symptomatic therapy for PD or 12 months, whichever came first. Subjects were randomized 1:1:1 to receive creatine 10 g/day, minocycline 200 mg/day, or matching placebo. The futility threshold was set as a 30% reduction in UPDRS progression based on the placebo/tocopherol arm of the Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism (DATATOP) trial. p values < or = 0.1 indicate futility. Two hundred subjects were randomized to the three groups. Neither creatine (p = 0.96) nor minocycline (p = 0.66) could be rejected as futile based on the DATATOP futility threshold. The rate of progression for the calibration placebo group fell outside the 95% CI for the DATATOP historical control. In a sensitivity analysis, based on the threshold derived from the calibration placebo group, again neither drug could be rejected as futile. Tolerability was 91% in the creatine group and 77% in the minocycline group. Common adverse events included upper respiratory symptoms (26%), joint pain (19%), and nausea (17%). Both creatine and minocycline should be considered for definitive Phase III trials to determine if they alter the long term progression of Parkinson disease (PD). Additional factors must be weighed before selecting agents for Phase III trials, including safety, tolerability, activity, cost, and availability of these two agents in comparison with other agents currently in development for PD. JF - Neurology AU - NINDS NET-PD Investigators AD - NINDS NET-PD Investigators Y1 - 2006/03/14/ PY - 2006 DA - 2006 Mar 14 SP - 664 EP - 671 VL - 66 IS - 5 KW - Anti-Bacterial Agents KW - 0 KW - Minocycline KW - FYY3R43WGO KW - Creatine KW - MU72812GK0 KW - Abridged Index Medicus KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Double-Blind Method KW - Humans KW - Aged KW - Middle Aged KW - Anti-Bacterial Agents -- toxicity KW - Disabled Persons KW - Male KW - Female KW - Minocycline -- toxicity KW - Creatine -- toxicity KW - Creatine -- therapeutic use KW - Parkinson Disease -- physiopathology KW - Minocycline -- therapeutic use KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67740976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=A+randomized%2C+double-blind%2C+futility+clinical+trial+of+creatine+and+minocycline+in+early+Parkinson+disease.&rft.au=NINDS+NET-PD+Investigators&rft.aulast=NINDS+NET-PD+Investigators&rft.aufirst=&rft.date=2006-03-14&rft.volume=66&rft.issue=5&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-24 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 2006 Mar 14;66(5):626-7 [16534098] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Prevalence of Recognized and Unrecognized Myocardial Infarction: The ICELAND MI Substudy to the AGES-Reykjavik Study T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40129299; 4154567 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Arai, Andrew E AU - Cao, Jie J AU - Sigurdsson, Sigurdur AU - Jonasson, Torfi AU - Vincent, Pamela AU - Kellman, Peter AU - Aletras, Anthony H AU - Aspelund, Thor AU - Thorgeirsson, Gudmunder AU - Launer, Lenore AU - Eiriksdottir, Gudny AU - Harris, Tamara AU - Gudnason, Vilmundur Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Atlantic, Iceland KW - Myocardial infarction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Prevalence+of+Recognized+and+Unrecognized+Myocardial+Infarction%3A+The+ICELAND+MI+Substudy+to+the+AGES-Reykjavik+Study&rft.au=Arai%2C+Andrew+E%3BCao%2C+Jie+J%3BSigurdsson%2C+Sigurdur%3BJonasson%2C+Torfi%3BVincent%2C+Pamela%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BAspelund%2C+Thor%3BThorgeirsson%2C+Gudmunder%3BLauner%2C+Lenore%3BEiriksdottir%2C+Gudny%3BHarris%2C+Tamara%3BGudnason%2C+Vilmundur&rft.aulast=Arai&rft.aufirst=Andrew&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relation Between Aortic Distensibility and Calcified Aortic Atherosclerosis: Cardiovascular Magentic Resonance Imaging and Computed Tomography Correlations T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40124934; 4154940 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Cao, Jie J AU - Gudnason, Vilmundur AU - Pang, Johnny AU - Johannes, Jimmy AU - Karlsdottir, Gyda AU - Sigurdsson, Sigurdur AU - Bandettini, W Patricia AU - Eiriksdottir, Gudny AU - Launer, Lenore AU - Harris, Tamara AU - Arai, Andrew E Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Arteriosclerosis KW - Imaging techniques KW - Computed tomography KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=The+Relation+Between+Aortic+Distensibility+and+Calcified+Aortic+Atherosclerosis%3A+Cardiovascular+Magentic+Resonance+Imaging+and+Computed+Tomography+Correlations&rft.au=Cao%2C+Jie+J%3BGudnason%2C+Vilmundur%3BPang%2C+Johnny%3BJohannes%2C+Jimmy%3BKarlsdottir%2C+Gyda%3BSigurdsson%2C+Sigurdur%3BBandettini%2C+W+Patricia%3BEiriksdottir%2C+Gudny%3BLauner%2C+Lenore%3BHarris%2C+Tamara%3BArai%2C+Andrew+E&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship Between Cardiopulmonary Exercise Testing and Pulmonary Pressures in Hypertrophic Cardiomyopathy T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 39161912; 4155107 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Arena, Ross AU - Owens, David S AU - Smith, Kevin AU - Mohiddin, Saidi A AU - McAreavey, Dorothea AU - Ulisney, Karen L AU - Fananapazir, Lameh AU - Plehn, Jonathan F Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Cardiomyopathy KW - Lung KW - Pressure KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39161912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Relationship+Between+Cardiopulmonary+Exercise+Testing+and+Pulmonary+Pressures+in+Hypertrophic+Cardiomyopathy&rft.au=Arena%2C+Ross%3BOwens%2C+David+S%3BSmith%2C+Kevin%3BMohiddin%2C+Saidi+A%3BMcAreavey%2C+Dorothea%3BUlisney%2C+Karen+L%3BFananapazir%2C+Lameh%3BPlehn%2C+Jonathan+F&rft.aulast=Arena&rft.aufirst=Ross&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Design and Synthesis of Promiscuous High-Affinity Monoamine Transporter Ligands: Unraveling Transporter Selectivity AN - 19394510; 7159766 AB - A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). All of the compounds showed high binding affinities for the DAT in the low to subnanomolar range. Their ability to bind to the SERT and the NET, while maintaining their high affinity for the DAT, could be altered by substitution in positions C2 and C3 of the phenylpropyl side-chain. This approach gave rise to a new set of compounds with selectivity for the DAT, the DAT and the SERT, or the DAT and the NET. Six compounds (7, 9, 11, 12, 14, and 20) with relatively low SERT/DAT ratios were selected for additional study in biogenic amine uptake inhibition assays based on the biogenic amine transporter binding results. Some of the new ligands can serve as pharmacological tools to block DAT or DAT and another transporter simultaneously. JF - Journal of Medicinal Chemistry AU - Greiner, E AU - Boos, T L AU - Prisinzano, TE AU - De Martino, MG AU - Zeglis, B AU - Dersch, C M AU - Marcus, J AU - Partilla, J S AU - Rothman, R B AU - Jacobson, A E AU - Rice, K C AD - Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA Y1 - 2006/03/09/ PY - 2006 DA - 2006 Mar 09 SP - 1766 EP - 1772 VL - 49 IS - 5 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Biogenic amines KW - Dopamine transporter KW - Norepinephrine transporter KW - Monoamine transporter KW - Serotonin transporter KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Design+and+Synthesis+of+Promiscuous+High-Affinity+Monoamine+Transporter+Ligands%3A+Unraveling+Transporter+Selectivity&rft.au=Greiner%2C+E%3BBoos%2C+T+L%3BPrisinzano%2C+TE%3BDe+Martino%2C+MG%3BZeglis%2C+B%3BDersch%2C+C+M%3BMarcus%2C+J%3BPartilla%2C+J+S%3BRothman%2C+R+B%3BJacobson%2C+A+E%3BRice%2C+K+C&rft.aulast=Greiner&rft.aufirst=E&rft.date=2006-03-09&rft.volume=49&rft.issue=5&rft.spage=1766&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050766f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dopamine transporter; Serotonin transporter; Biogenic amines; Norepinephrine transporter; Monoamine transporter DO - http://dx.doi.org/10.1021/jm050766f ER - TY - CPAPER T1 - Altered TGF-Beta Function in Temporomandibular Joint Osteoarthritis T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 40005129; 4202731 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Embree, M AU - Bi, Y. AU - Wadhwa, S AU - Ameye, L AU - Wimer, H AU - Li, L. AU - Young, M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Temporomandibular joint KW - Transforming growth factor-^b KW - Osteoarthritis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40005129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Altered+TGF-Beta+Function+in+Temporomandibular+Joint+Osteoarthritis&rft.au=Embree%2C+M%3BBi%2C+Y.%3BWadhwa%2C+S%3BAmeye%2C+L%3BWimer%2C+H%3BLi%2C+L.%3BYoung%2C+M&rft.aulast=Embree&rft.aufirst=M&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salivary Biomarkers in Parotid Saliva of Sjogren's Syndrome T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39996627; 4204422 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Atkinson, J C AU - Ryu, O AU - Hoehn, G AU - Illei, G AU - Hart, T Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Bioindicators KW - Sjogren's syndrome KW - Saliva KW - Biomarkers KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39996627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Salivary+Biomarkers+in+Parotid+Saliva+of+Sjogren%27s+Syndrome&rft.au=Atkinson%2C+J+C%3BRyu%2C+O%3BHoehn%2C+G%3BIllei%2C+G%3BHart%2C+T&rft.aulast=Atkinson&rft.aufirst=J&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Craniofacial and Intraoral Soft Tissue Findings in Hyper-IgE Syndrome Patients T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39975428; 4202788 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Domingo, D L AU - Tomona, N AU - Singh, G D AU - Hart, T Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Soft tissues KW - Job's syndrome KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39975428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Craniofacial+and+Intraoral+Soft+Tissue+Findings+in+Hyper-IgE+Syndrome+Patients&rft.au=Domingo%2C+D+L%3BTomona%2C+N%3BSingh%2C+G+D%3BHart%2C+T&rft.aulast=Domingo&rft.aufirst=D&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Mammalian-SIRT, Homolog of Yeast-Sir2-Protein during Adipogenesis and Calorie-Restriction T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39944732; 4203555 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Liu, S AU - Michishita, E AU - Nunez, N AU - Hursting, S AU - Barrett, C AU - Horikawa, I Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Adipogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Analysis+of+Mammalian-SIRT%2C+Homolog+of+Yeast-Sir2-Protein+during+Adipogenesis+and+Calorie-Restriction&rft.au=Liu%2C+S%3BMichishita%2C+E%3BNunez%2C+N%3BHursting%2C+S%3BBarrett%2C+C%3BHorikawa%2C+I&rft.aulast=Liu&rft.aufirst=S&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FGF-Receptors Regulate Laminina5 and MMPs Expression During Submandibular Gland Morphogenesis T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39930242; 4204437 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Layvey, A AU - Rebustini, I AU - Hoffman, M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Morphogenesis KW - Submandibular gland KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=FGF-Receptors+Regulate+Laminina5+and+MMPs+Expression+During+Submandibular+Gland+Morphogenesis&rft.au=Layvey%2C+A%3BRebustini%2C+I%3BHoffman%2C+M&rft.aulast=Layvey&rft.aufirst=A&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Periodontal Disease Severity Using Partial Recording Protocols T2 - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AN - 39922668; 4202632 JF - 35th Annual Meeting and Exhibition of the American Association for Dental Research, 30th Annual Meeting of the Canadian Association for Dental Research and 83rd Annual Meeting and Exhibition of American Dental Education Association AU - Kingman, A AU - Susin, C AU - Albandar, J M Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 KW - Periodontal diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.atitle=Assessing+Periodontal+Disease+Severity+Using+Partial+Recording+Protocols&rft.au=Kingman%2C+A%3BSusin%2C+C%3BAlbandar%2C+J+M&rft.aulast=Kingman&rft.aufirst=A&rft.date=2006-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+and+Exhibition+of+the+American+Association+for+Dental+Research%2C+30th+Annual+Meeting+of+the+Canadian+Association+for+Dental+Research+and+83rd+Annual+Meeting+and+Exhibition+of+American+Dental+Education+Association&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Orld/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. AN - 67749098; 16537462 AB - Calcium channels in the plasma membrane rarely remain open for much more than a millisecond at any one time, which avoids raising intracellular calcium to toxic levels. However, the dihydropyridine-sensitive calcium channels of the CaV1 family, which selectively couple electrical excitation to endocrine secretion, cardiovascular contractility, and neuronal transcription, have a unique second mode of gating, "mode 2," that involves frequent openings of much longer duration. Here we report that two human conditions, cyclosporin neurotoxicity and Timothy syndrome, increase mode 2 gating of the recombinant rabbit CaV1.2 channel. In each case, mode 2 gating depends on a Ser residue at the cytoplasmic end of the S6 helix in domain I (Ser-439, Timothy syndrome) or domain IV (Ser-1517, cyclosporin). Both Ser reside in consensus sequences for type II calmodulin-dependent protein kinase. Pharmacologically inhibiting type II calmodulin-dependent protein kinase or mutating the Ser residues to Ala prevents the increase in mode 2 gating. We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Erxleben, Christian AU - Liao, Yanhong AU - Gentile, Saverio AU - Chin, David AU - Gomez-Alegria, Claudio AU - Mori, Yasuo AU - Birnbaumer, Lutz AU - Armstrong, David L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3932 EP - 3937 VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Calcium Channels, L-Type KW - 0 KW - L-type calcium channel alpha(1C) KW - Recombinant Proteins KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Animals KW - Models, Molecular KW - Humans KW - Rabbits KW - Recombinant Proteins -- genetics KW - Ion Channel Gating -- drug effects KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Syndrome KW - In Vitro Techniques KW - Point Mutation KW - Recombinant Proteins -- chemistry KW - Amino Acid Substitution KW - Protein Conformation KW - Calcium Channels, L-Type -- drug effects KW - Metal Metabolism, Inborn Errors -- genetics KW - Metal Metabolism, Inborn Errors -- metabolism KW - Calcium Channels, L-Type -- chemistry KW - Calcium Channels, L-Type -- metabolism KW - Cyclosporine -- toxicity KW - Calcium Channels, L-Type -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67749098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Cyclosporin+and+Timothy+syndrome+increase+mode+2+gating+of+CaV1.2+calcium+channels+through+aberrant+phosphorylation+of+S6+helices.&rft.au=Erxleben%2C+Christian%3BLiao%2C+Yanhong%3BGentile%2C+Saverio%3BChin%2C+David%3BGomez-Alegria%2C+Claudio%3BMori%2C+Yasuo%3BBirnbaumer%2C+Lutz%3BArmstrong%2C+David+L&rft.aulast=Erxleben&rft.aufirst=Christian&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3932&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-17 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Physiol. 1986 Sep;378:31-51 [2432251] J Cell Biol. 2005 Nov 7;171(3):537-47 [16275756] Am J Physiol. 1990 Aug;259(2 Pt 2):H639-42 [2167026] Ann N Y Acad Sci. 1991;635:26-34 [1660238] Immunol Today. 1992 Apr;13(4):136-42 [1374612] J Gen Physiol. 1997 Nov;110(5):503-13 [9348323] J Biol Chem. 1998 Dec 25;273(52):34857-67 [9857013] Am J Physiol Cell Physiol. 2004 Dec;287(6):C1717-24 [15525689] Nat Neurosci. 2005 Jun;8(6):791-6 [15880107] J Clin Invest. 2005 Aug;115(8):1986-9 [16075038] J Gen Physiol. 2005 Sep;126(3):205-12 [16129771] Nat Cell Biol. 2000 Mar;2(3):173-7 [10707089] Curr Top Cell Regul. 2000;36:237-95 [10842755] Trends Cell Biol. 2000 Aug;10(8):322-8 [10884684] Annu Rev Cell Dev Biol. 2000;16:521-55 [11031246] Biochem J. 2000 Oct 1;351(Pt 1):95-105 [10998351] Science. 2001 Oct 12;294(5541):333-9 [11598293] J Physiol. 2002 Oct 1;544(Pt 1):57-69 [12356880] Biochemistry. 2002 Nov 26;41(47):14001-9 [12437357] Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2929-34 [12601159] J Neurosci. 2003 Nov 5;23(31):10116-21 [14602827] Mol Interv. 2004 Apr;4(2):97-107 [15087483] Trends Cardiovasc Med. 2004 May;14(4):152-61 [15177266] Cell. 2004 Oct 1;119(1):19-31 [15454078] J Neurosci. 2004 Sep 29;24(39):8391-3 [15456809] J Neurosci. 2004 Sep 29;24(39):8404-9 [15456812] Proc Natl Acad Sci U S A. 1984 Aug;81(15):4824-7 [6205402] Nature. 1984 Oct 11-17;311(5986):538-44 [6207437] J Mol Cell Cardiol. 1986 Jul;18(7):691-710 [2427730] J Neurosci. 2005 Oct 26;25(43):9883-92 [16251435] Biochem J. 1988 Nov 15;256(1):283-90 [2851982] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Observed Changes in Liver-Associated Enzymes During Long Term Inpatient Phase 1 Clinical Trials T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40139889; 4079179 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Cherstniakova, Svetlana Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - clinical trials KW - Enzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40139889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Observed+Changes+in+Liver-Associated+Enzymes+During+Long+Term+Inpatient+Phase+1+Clinical+Trials&rft.au=Cherstniakova%2C+Svetlana&rft.aulast=Cherstniakova&rft.aufirst=Svetlana&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges Encountered in Development of Anti-Obesity Drugs T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40139846; 4079166 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Staten, Myrlene Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40139846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Challenges+Encountered+in+Development+of+Anti-Obesity+Drugs&rft.au=Staten%2C+Myrlene&rft.aulast=Staten&rft.aufirst=Myrlene&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Cytochrome P450 3A4 (CYP3A4) by Vinblastine: Role of the Nuclear Receptor NR1I2 T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40116505; 4079226 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Smith, Nicola F Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Cytochrome P450 KW - Nuclear receptors KW - Vinblastine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=Induction+of+Cytochrome+P450+3A4+%28CYP3A4%29+by+Vinblastine%3A+Role+of+the+Nuclear+Receptor+NR1I2&rft.au=Smith%2C+Nicola+F&rft.aulast=Smith&rft.aufirst=Nicola&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From a Policy Makers Perspective The Present and Future of the Race and Pharmacogenetics Debate in the Imminent Theranostics Age T2 - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AN - 40066667; 4079229 JF - 2006 Annaul Meeting of the American Society for Clinical Pharmacology and Therapeutics AU - Arena, J Fernando Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Policies KW - Subpopulations KW - Races KW - Pharmacogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40066667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.atitle=From+a+Policy+Makers+Perspective+The+Present+and+Future+of+the+Race+and+Pharmacogenetics+Debate+in+the+Imminent+Theranostics+Age&rft.au=Arena%2C+J+Fernando&rft.aulast=Arena&rft.aufirst=J&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annaul+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2006/2006_brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outlier Detection as a Spatial Data Mining Tool for National Cancer Surveillance T2 - 2006 Meeting of the Association of American Geographers AN - 39768601; 4082651 JF - 2006 Meeting of the Association of American Geographers AU - Stinchcomb, David AU - Pickle, Linda Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 KW - Cancer KW - Data processing KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+of+the+Association+of+American+Geographers&rft.atitle=Outlier+Detection+as+a+Spatial+Data+Mining+Tool+for+National+Cancer+Surveillance&rft.au=Stinchcomb%2C+David%3BPickle%2C+Linda&rft.aulast=Stinchcomb&rft.aufirst=David&rft.date=2006-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+of+the+Association+of+American+Geographers&rft.issn=&rft_id=info:doi/ L2 - http://communicate.aag.org/eseries/aag_org/program/index.cfm?mtgID=51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A milestone for hepatitis C virus research: A virus generated in cell culture is fully viable in vivo AN - 20198710; 6749234 JF - Proceedings of the National Academy of Sciences, USA AU - Bukh, Jens AU - Purcell, Robert H AD - Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3500 EP - 3501 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Hepatitis C virus KW - Cell culture KW - V 22410:Animal Diseases KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20198710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+milestone+for+hepatitis+C+virus+research%3A+A+virus+generated+in+cell+culture+is+fully+viable+in+vivo&rft.au=Bukh%2C+Jens%3BPurcell%2C+Robert+H&rft.aulast=Bukh&rft.aufirst=Jens&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3500&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell culture; Hepatitis C virus ER - TY - JOUR T1 - Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants AN - 17120761; 6749302 AB - Neurotrophic factors are agents with a promising ability to retard progression of neurodegenerative diseases and are effective in slowing photoreceptor degeneration in animal models of retinitis pigmentosa. Here we report a human clinical trial of a neurotrophic factor for retinal neurodegeneration. In this Phase I safety trial, human ciliary neurotrophic factor (CNTF) was delivered by cells transfected with the human CNTF gene and sequestered within capsules that were surgically implanted into the vitreous of the eye. The outer membrane of the encapsulated cell implant is semipermeable to allow CNTF to reach the retina. Ten participants received CNTF implants in one eye. When the implants were removed after 6 months, they contained viable cells with minimal cell loss and gave CNTF output at levels previously shown to be therapeutic for retinal degeneration in rcd1 dogs. Although the trial was not powered to form a judgment as to clinical efficacy, of seven eyes for which visual acuity could be tracked by conventional reading charts, three eyes reached and maintained improved acuities of 10-15 letters, equivalent to two- to three-line improvement on standard Snellen acuity charts. A surgically related choroidal detachment in one eye resulted in a transient acuity decrease that resolved with conservative management. This Phase I trial indicated that CNTF is safe for the human retina even with severely compromised photoreceptors. The approach to delivering therapeutic proteins to degenerating retinas using encapsulated cell implants may have application beyond disease caused by genetic mutations. JF - Proceedings of the National Academy of Sciences, USA AU - Sieving, Paul A AU - Caruso, Rafael C AU - Tao, Weng AU - Coleman, Hanna R AU - Thompson, Darby JS AU - Fullmer, Keri R AU - Bush, Ronald A AD - National Eye Institute and National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03/07/ PY - 2006 DA - 2006 Mar 07 SP - 3896 EP - 3901 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 10 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; CSA Neurosciences Abstracts KW - retinal degeneration KW - Ciliary neurotrophic factor KW - Animal models KW - Acuity KW - Photoreceptors KW - Neurodegenerative diseases KW - Eye diseases KW - Retinitis pigmentosa KW - N3 11015:Visual systems (retinal and central) KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17120761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Ciliary+neurotrophic+factor+%28CNTF%29+for+human+retinal+degeneration%3A+Phase+I+trial+of+CNTF+delivered+by+encapsulated+cell+intraocular+implants&rft.au=Sieving%2C+Paul+A%3BCaruso%2C+Rafael+C%3BTao%2C+Weng%3BColeman%2C+Hanna+R%3BThompson%2C+Darby+JS%3BFullmer%2C+Keri+R%3BBush%2C+Ronald+A&rft.aulast=Sieving&rft.aufirst=Paul&rft.date=2006-03-07&rft.volume=103&rft.issue=10&rft.spage=3896&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acuity; Eye diseases; Ciliary neurotrophic factor; retinal degeneration; Animal models; Photoreceptors; Retinitis pigmentosa; Neurodegenerative diseases ER - TY - JOUR T1 - Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial. AN - 67679617; 16256250 AB - HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines. JF - Vaccine AU - Deloria-Knoll, Maria AU - Steinhoff, Mark AU - Semba, Richard D AU - Nelson, Kenrad AU - Vlahov, David AU - Meinert, Curtis L AD - National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. mknoll@jhsph.edu Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 SP - 1670 EP - 1679 VL - 24 IS - 10 SN - 0264-410X, 0264-410X KW - Antibodies, Bacterial KW - 0 KW - Pneumococcal Vaccines KW - Vaccines, Conjugate KW - Vitamin A KW - 11103-57-4 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Vaccines, Conjugate -- immunology KW - Humans KW - Adult KW - Middle Aged KW - Dietary Supplements KW - Male KW - Immunization KW - Female KW - Zinc -- administration & dosage KW - Vitamin A -- blood KW - Pneumococcal Vaccines -- adverse effects KW - Vitamin A -- administration & dosage KW - Antibodies, Bacterial -- blood KW - Substance Abuse, Intravenous -- immunology KW - HIV Seropositivity -- immunology KW - Pneumococcal Vaccines -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Effect+of+zinc+and+vitamin+A+supplementation+on+antibody+responses+to+a+pneumococcal+conjugate+vaccine+in+HIV-positive+injection+drug+users%3A+a+randomized+trial.&rft.au=Deloria-Knoll%2C+Maria%3BSteinhoff%2C+Mark%3BSemba%2C+Richard+D%3BNelson%2C+Kenrad%3BVlahov%2C+David%3BMeinert%2C+Curtis+L&rft.aulast=Deloria-Knoll&rft.aufirst=Maria&rft.date=2006-03-06&rft.volume=24&rft.issue=10&rft.spage=1670&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-12 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Pdcd4 Targets eIF4A to Inhibit Translation, Transcription Tumorigenesis, and Invasion T2 - 2006 Keystone Symposia on Molecular Targets for Cancer Prevention (C7) AN - 40141332; 4098786 JF - 2006 Keystone Symposia on Molecular Targets for Cancer Prevention (C7) AU - Colburn, Nancy H Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Translation KW - Transcription KW - Tumorigenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Targets+for+Cancer+Prevention+%28C7%29&rft.atitle=Pdcd4+Targets+eIF4A+to+Inhibit+Translation%2C+Transcription+Tumorigenesis%2C+and+Invasion&rft.au=Colburn%2C+Nancy+H&rft.aulast=Colburn&rft.aufirst=Nancy&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Targets+for+Cancer+Prevention+%28C7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging of Cardiac Autonomic Involvement in Neurodegenerative Disorders T2 - Second Annual Update Symposium Series on Clinical Neurology and Neurophysiology AN - 39823640; 4084659 JF - Second Annual Update Symposium Series on Clinical Neurology and Neurophysiology AU - Goldstein, David S Y1 - 2006/03/06/ PY - 2006 DA - 2006 Mar 06 KW - Neuroimaging KW - Neurodegenerative diseases KW - Heart KW - Autonomic nervous system KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Update+Symposium+Series+on+Clinical+Neurology+and+Neurophysiology&rft.atitle=Imaging+of+Cardiac+Autonomic+Involvement+in+Neurodegenerative+Disorders&rft.au=Goldstein%2C+David+S&rft.aulast=Goldstein&rft.aufirst=David&rft.date=2006-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Update+Symposium+Series+on+Clinical+Neurology+and+Neurophysiology&rft.issn=&rft_id=info:doi/ L2 - http://www.neurophysiology-symposium.com/program_neurology2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deducing Mammalian Genome Function by Multi-Species Comparative Sequencing T2 - 2006 Keystone Symposia on Systems Biology: Integrating Biology, Technology and Computation (C6) AN - 40085014; 4098771 JF - 2006 Keystone Symposia on Systems Biology: Integrating Biology, Technology and Computation (C6) AU - Green, Eric D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40085014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Systems+Biology%3A+Integrating+Biology%2C+Technology+and+Computation+%28C6%29&rft.atitle=Deducing+Mammalian+Genome+Function+by+Multi-Species+Comparative+Sequencing&rft.au=Green%2C+Eric+D&rft.aulast=Green&rft.aufirst=Eric&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Systems+Biology%3A+Integrating+Biology%2C+Technology+and+Computation+%28C6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=789 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Alterations in Immune System Pathways Following Exposure to Immunosuppressive Chemicals T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40003250; 4146179 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Patterson, R AU - Walker, N AU - White Jr, K AU - Brown, R AU - Musgrove, D AU - Harrison, S AU - Germolec, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Immune system KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Gene+Expression+Alterations+in+Immune+System+Pathways+Following+Exposure+to+Immunosuppressive+Chemicals&rft.au=Patterson%2C+R%3BWalker%2C+N%3BWhite+Jr%2C+K%3BBrown%2C+R%3BMusgrove%2C+D%3BHarrison%2C+S%3BGermolec%2C+D&rft.aulast=Patterson&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Resistance In Cadmium-Transformed Human Prostate Epithelial Cells. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40002722; 4146464 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Qu, W. AU - Ke, H. AU - Broderick, D AU - French, J E AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Epithelial cells KW - Prostate KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Apoptotic+Resistance+In+Cadmium-Transformed+Human+Prostate+Epithelial+Cells.&rft.au=Qu%2C+W.%3BKe%2C+H.%3BBroderick%2C+D%3BFrench%2C+J+E%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Qu&rft.aufirst=W.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 40002571; 4146428 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Doerrer, N AU - Boobis, A AU - Bucher, J AU - Cohen, S AU - Jacobson Kram, D AU - MacDonald, J AU - Wolf, D Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cancer KW - Hazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Data-Based+Assessment+of+Alternative+Strategies+for+Identification+of+Potential+Human+Cancer+Hazards&rft.au=Doerrer%2C+N%3BBoobis%2C+A%3BBucher%2C+J%3BCohen%2C+S%3BJacobson+Kram%2C+D%3BMacDonald%2C+J%3BWolf%2C+D&rft.aulast=Doerrer&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-Specific Toxicity Reduction by Encapsulating Toxins in Nanoliposomes: A Theoretical Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39964166; 4146523 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Dimitrov, D AU - Sidorov, I A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Toxins KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39964166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Non-Specific+Toxicity+Reduction+by+Encapsulating+Toxins+in+Nanoliposomes%3A+A+Theoretical+Model&rft.au=Dimitrov%2C+D%3BSidorov%2C+I+A&rft.aulast=Dimitrov&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis of Hepatoprotective Zinc Exposure in Mice and Rats. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39961714; 4146463 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Liu, J AU - Boos, J AU - Zhang, W AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Zinc KW - Mice KW - Rats KW - Genomic analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genomic+Analysis+of+Hepatoprotective+Zinc+Exposure+in+Mice+and+Rats.&rft.au=Liu%2C+J%3BBoos%2C+J%3BZhang%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diet, Obesity and Chemical Carcinogenesis: Experimental Approaches. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39961323; 4146348 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Hursting, S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Diets KW - Obesity KW - Carcinogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39961323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Diet%2C+Obesity+and+Chemical+Carcinogenesis%3A+Experimental+Approaches.&rft.au=Hursting%2C+S&rft.aulast=Hursting&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Mitochondrial DNA and Telomerase in Toxic Oxidative Stress Responses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946836; 4144936 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Van Houten, B AU - Santos, J H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Stress KW - Oxidative stress KW - Mitochondrial DNA KW - Telomerase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Role+of+Mitochondrial+DNA+and+Telomerase+in+Toxic+Oxidative+Stress+Responses&rft.au=Van+Houten%2C+B%3BSantos%2C+J+H&rft.aulast=Van+Houten&rft.aufirst=B&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is There a Threshold Level for Alterations in Thyroid Hormone concentrations in the Production of Thyroid Tumors in F344/N Rats? T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946411; 4146097 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Travlos, G AU - Pearse, G AU - Betz, L AU - Hooth, M AU - Harvey, E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hormones KW - Rats KW - Thyroid hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Is+There+a+Threshold+Level+for+Alterations+in+Thyroid+Hormone+concentrations+in+the+Production+of+Thyroid+Tumors+in+F344%2FN+Rats%3F&rft.au=Travlos%2C+G%3BPearse%2C+G%3BBetz%2C+L%3BHooth%2C+M%3BHarvey%2C+E&rft.aulast=Travlos&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrasonic Analysis, A Tool for Early Detection of Cardiotoxic Lesions: Preliminary Findings T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39946209; 4146453 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Dunnick, J AU - Rouse, D AU - Myers, P AU - Vanderklok, C AU - Nyska, A AU - Johnson, J AU - Horton, J AU - Lieuallen, W AU - Malarkey, D AU - Maronpot, R R AU - Johnson, K Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Ultrasonics KW - Lesions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39946209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Ultrasonic+Analysis%2C+A+Tool+for+Early+Detection+of+Cardiotoxic+Lesions%3A+Preliminary+Findings&rft.au=Dunnick%2C+J%3BRouse%2C+D%3BMyers%2C+P%3BVanderklok%2C+C%3BNyska%2C+A%3BJohnson%2C+J%3BHorton%2C+J%3BLieuallen%2C+W%3BMalarkey%2C+D%3BMaronpot%2C+R+R%3BJohnson%2C+K&rft.aulast=Dunnick&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on the Role of Metallothionein and Synuclein in Lead-Induced Inclusion Body Formation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39943888; 4146637 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Zuo, P AU - Qu, W. AU - Cooper, R AU - Goyer, R A AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lead KW - Inclusion bodies KW - Synuclein KW - Metallothionein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39943888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+on+the+Role+of+Metallothionein+and+Synuclein+in+Lead-Induced+Inclusion+Body+Formation&rft.au=Zuo%2C+P%3BQu%2C+W.%3BCooper%2C+R%3BGoyer%2C+R+A%3BWaalkes%2C+M+P&rft.aulast=Zuo&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of Nur77 and Cell Signaling Pathways in Tributyltin-Induced Apoptosis in Mouse Testicular Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39942640; 4146496 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lee, K AU - Jeong, H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Signal transduction KW - Apoptosis KW - Nur77 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Involvement+of+Nur77+and+Cell+Signaling+Pathways+in+Tributyltin-Induced+Apoptosis+in+Mouse+Testicular+Cells&rft.au=Lee%2C+K%3BJeong%2C+H&rft.aulast=Lee&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Whole Blood Carries Gene Expression Signatures Indicative of APAP-induced Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39935663; 4144587 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Heinloth, A N AU - Parker, J AU - Chou, J AU - Boorman, G AU - Irwin, R AU - Cunningham, M AU - Snell, M AU - Tennant, R AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Blood KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Whole+Blood+Carries+Gene+Expression+Signatures+Indicative+of+APAP-induced+Toxicity&rft.au=Heinloth%2C+A+N%3BParker%2C+J%3BChou%2C+J%3BBoorman%2C+G%3BIrwin%2C+R%3BCunningham%2C+M%3BSnell%2C+M%3BTennant%2C+R%3BPaules%2C+R+S&rft.aulast=Heinloth&rft.aufirst=A&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Oral and Dermal Toxicity of Tert-Butyl Hydroperoxide in Fischer 344 Rats and B6C3F1 Mice. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39935262; 4144513 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Aldridge, J AU - Doi, A AU - Ritchie, G D AU - Colleton, C A AU - Hejtmancik, M AU - Chhabra, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Mice KW - Rats KW - Skin KW - Tert-butyl hydroperoxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39935262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Oral+and+Dermal+Toxicity+of+Tert-Butyl+Hydroperoxide+in+Fischer+344+Rats+and+B6C3F1+Mice.&rft.au=Aldridge%2C+J%3BDoi%2C+A%3BRitchie%2C+G+D%3BColleton%2C+C+A%3BHejtmancik%2C+M%3BChhabra%2C+R&rft.aulast=Aldridge&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reference Substances for the Validation of in Vitro Ocular Toxicity Test Methods for the Evaluation of Ocular Corrosives and Severe Irritants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39934518; 4144856 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Allen, D AU - Blackard, B AU - Choksi, N AU - Truax, J AU - Tice, R AU - Stokes, W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Corrosion KW - Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reference+Substances+for+the+Validation+of+in+Vitro+Ocular+Toxicity+Test+Methods+for+the+Evaluation+of+Ocular+Corrosives+and+Severe+Irritants&rft.au=Allen%2C+D%3BBlackard%2C+B%3BChoksi%2C+N%3BTruax%2C+J%3BTice%2C+R%3BStokes%2C+W&rft.aulast=Allen&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Prion Transduces Neuroprotective Signals via PI3K/AKT Pathways T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39931428; 4144454 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lee, K J AU - Jeong, H Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - 1-Phosphatidylinositol 3-kinase KW - Neuroprotection KW - Prion protein KW - AKT protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Cellular+Prion+Transduces+Neuroprotective+Signals+via+PI3K%2FAKT+Pathways&rft.au=Lee%2C+K+J%3BJeong%2C+H&rft.aulast=Lee&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39930064; 4145180 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Guo, G L AU - Moffit, J S AU - Nicol, C J AU - Ward, J M AU - Aleksunes, L A AU - Kliewer, S A AU - Manauto, J E AU - Gonzalez, F J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Pregnane X receptors KW - Acetaminophen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Enhanced+Acetaminophen+Toxicity+by+Activation+of+the+Pregnane+X+Receptor&rft.au=Guo%2C+G+L%3BMoffit%2C+J+S%3BNicol%2C+C+J%3BWard%2C+J+M%3BAleksunes%2C+L+A%3BKliewer%2C+S+A%3BManauto%2C+J+E%3BGonzalez%2C+F+J&rft.aulast=Guo&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relative Carcinogenic Potency of PCB 126 and PeCDF in Dermally Exposed Female Tg.AC Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39927201; 4146029 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Wyde, M E AU - Nyska, A AU - Vallant, M AU - Fomby, L M AU - Hejtmancik, M AU - Easterling, M AU - Bucher, J R AU - Walker, N J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Carcinogenicity KW - PCB KW - Polychlorinated biphenyls UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Relative+Carcinogenic+Potency+of+PCB+126+and+PeCDF+in+Dermally+Exposed+Female+Tg.AC+Mice&rft.au=Wyde%2C+M+E%3BNyska%2C+A%3BVallant%2C+M%3BFomby%2C+L+M%3BHejtmancik%2C+M%3BEasterling%2C+M%3BBucher%2C+J+R%3BWalker%2C+N+J&rft.aulast=Wyde&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alteration in Carcinogenic Potency of PCB126 by PCB153 Following Chronic Exposure in Female Rats. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39927153; 4146028 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Walker, N J AU - Wyde, M E AU - Easterling, M AU - Nyska, A AU - Portier, C R AU - Bucher, J R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Carcinogenicity KW - Rats KW - Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Alteration+in+Carcinogenic+Potency+of+PCB126+by+PCB153+Following+Chronic+Exposure+in+Female+Rats.&rft.au=Walker%2C+N+J%3BWyde%2C+M+E%3BEasterling%2C+M%3BNyska%2C+A%3BPortier%2C+C+R%3BBucher%2C+J+R&rft.aulast=Walker&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 14-Week Oral Toxicity Studies of Kava In F344 Rats: Immunohistochemical Analysis of Expressions of Hepatic Cytochrome P450 T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39918190; 4146260 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Clayton, N P AU - Yoshizawa, K AU - Kissling, G AU - Chan, P AU - Burka, L T AU - Nyska, A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cytochrome P450 KW - Toxicity KW - Rats KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=14-Week+Oral+Toxicity+Studies+of+Kava+In+F344+Rats%3A+Immunohistochemical+Analysis+of+Expressions+of+Hepatic+Cytochrome+P450&rft.au=Clayton%2C+N+P%3BYoshizawa%2C+K%3BKissling%2C+G%3BChan%2C+P%3BBurka%2C+L+T%3BNyska%2C+A&rft.aulast=Clayton&rft.aufirst=N&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on Blood Metallothionein as a Biomarker of Tissue Metallothionein Expression. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39917137; 4146477 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Shen, J AU - Liu, J AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Blood KW - Metallothionein KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+on+Blood+Metallothionein+as+a+Biomarker+of+Tissue+Metallothionein+Expression.&rft.au=Shen%2C+J%3BLiu%2C+J%3BWaalkes%2C+M+P&rft.aulast=Shen&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Epigenetics in the Fetal Basis of Adult Disease T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39912814; 4146708 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jirtle, R AU - Heindel, J J AU - Newbold, R AU - Archer, T k AU - Skinner, M AU - Walker, C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Fetuses KW - Epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Role+of+Epigenetics+in+the+Fetal+Basis+of+Adult+Disease&rft.au=Jirtle%2C+R%3BHeindel%2C+J+J%3BNewbold%2C+R%3BArcher%2C+T+k%3BSkinner%2C+M%3BWalker%2C+C&rft.aulast=Jirtle&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidation of a Gene Regulatory Network for Forebrain Development using Bioinformatics Approaches for the Analysis of Compiled Microarray Datasets T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910801; 4146366 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Gohlke, J M AU - Parham, F M AU - Parker, J S AU - Smith, M V AU - Portier, C J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Forebrain KW - Computer programs KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Elucidation+of+a+Gene+Regulatory+Network+for+Forebrain+Development+using+Bioinformatics+Approaches+for+the+Analysis+of+Compiled+Microarray+Datasets&rft.au=Gohlke%2C+J+M%3BParham%2C+F+M%3BParker%2C+J+S%3BSmith%2C+M+V%3BPortier%2C+C+J&rft.aulast=Gohlke&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility and Ozone Exacerbation of Allergic Asthma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910669; 4146342 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kleeberger, S R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Respiratory diseases KW - Ozone KW - Asthma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genetic+Susceptibility+and+Ozone+Exacerbation+of+Allergic+Asthma&rft.au=Kleeberger%2C+S+R&rft.aulast=Kleeberger&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility of the TRP53 Haploinsufficient Mouse to Radiation Induced Lymphoma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39910017; 4144634 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - French, J E AU - Parron, V Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Lymphoma KW - Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Genetic+Susceptibility+of+the+TRP53+Haploinsufficient+Mouse+to+Radiation+Induced+Lymphoma&rft.au=French%2C+J+E%3BParron%2C+V&rft.aulast=French&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hepatoprotective Interleukin-13 Diversely Affects Cytokines and Chemokines in Acetaminophen-Induced Murine Liver Disease T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39909816; 4144597 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Yee, S B AU - Bourdi, M AU - Pohl, L R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Liver diseases KW - Chemokines KW - Interleukin 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Hepatoprotective+Interleukin-13+Diversely+Affects+Cytokines+and+Chemokines+in+Acetaminophen-Induced+Murine+Liver+Disease&rft.au=Yee%2C+S+B%3BBourdi%2C+M%3BPohl%2C+L+R&rft.aulast=Yee&rft.aufirst=S&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reproducibility Analyses for In Vitro Neutral Red Uptake Methods from a Validation Study to Evaluate In Vitro Cytotoxicity Assays for Estimating Rodent Acute Systemic Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39909542; 4146410 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Paris, M AU - Strickland, J AU - Casati, S AU - Tice, R AU - Stokes, W AU - Raabe, H AU - Cao, C AU - Clothier, R AU - Clothier,J. AU - Mun, G AU - Sizemore, A AU - Moyer, G O AU - Madren-Whalley, J AU - Krishna, C AU - Owen, M AU - Bourne, N AU - Harvey,E. AU - Lee, R AU - Haseman, J AU - Crockett, P AU - Wenk, M AU - Vallant, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Cytotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reproducibility+Analyses+for+In+Vitro+Neutral+Red+Uptake+Methods+from+a+Validation+Study+to+Evaluate+In+Vitro+Cytotoxicity+Assays+for+Estimating+Rodent+Acute+Systemic+Toxicity&rft.au=Paris%2C+M%3BStrickland%2C+J%3BCasati%2C+S%3BTice%2C+R%3BStokes%2C+W%3BRaabe%2C+H%3BCao%2C+C%3BClothier%2C+R%3BClothier%2CJ.%3BMun%2C+G%3BSizemore%2C+A%3BMoyer%2C+G+O%3BMadren-Whalley%2C+J%3BKrishna%2C+C%3BOwen%2C+M%3BBourne%2C+N%3BHarvey%2CE.%3BLee%2C+R%3BHaseman%2C+J%3BCrockett%2C+P%3BWenk%2C+M%3BVallant%2C+M&rft.aulast=Paris&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Baseline Animal Microarray Database for Biological Response Identification and Biomarker Validation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39906595; 4144870 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Fostel, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Bioindicators KW - Databases KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=A+Baseline+Animal+Microarray+Database+for+Biological+Response+Identification+and+Biomarker+Validation&rft.au=Fostel%2C+J&rft.aulast=Fostel&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Relationship Between In Vivo Rabbit Eye Test Scores and their Reversibility T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39906564; 4144859 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tice, R R AU - Allen, D G AU - Choksi, N Y AU - Truax, J F AU - Stokes, W S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Eye UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Evaluation+of+the+Relationship+Between+In+Vivo+Rabbit+Eye+Test+Scores+and+their+Reversibility&rft.au=Tice%2C+R+R%3BAllen%2C+D+G%3BChoksi%2C+N+Y%3BTruax%2C+J+F%3BStokes%2C+W+S&rft.aulast=Tice&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of Magnetic Resonance Imaging in Developmental Neurotoxicity Testing: A Pilot Study T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39905331; 4145114 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Johnson, K AU - Ryan, L AU - Davis, J AU - Elmore, A AU - Guenther, B AU - Marcus, J AU - Maronpot, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Neurotoxicity KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Application+of+Magnetic+Resonance+Imaging+in+Developmental+Neurotoxicity+Testing%3A+A+Pilot+Study&rft.au=Johnson%2C+K%3BRyan%2C+L%3BDavis%2C+J%3BElmore%2C+A%3BGuenther%2C+B%3BMarcus%2C+J%3BMaronpot%2C+R+R&rft.aulast=Johnson&rft.aufirst=K&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mice Deficient in Cyclooxygenase-2 are More Susceptible than Wild-Types to Kainic Acid Excitotoxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39905060; 4144427 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Toscano, C D AU - Bosetti, F Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice KW - Excitotoxicity KW - Kainic acid KW - Cyclooxygenase-2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Mice+Deficient+in+Cyclooxygenase-2+are+More+Susceptible+than+Wild-Types+to+Kainic+Acid+Excitotoxicity&rft.au=Toscano%2C+C+D%3BBosetti%2C+F&rft.aulast=Toscano&rft.aufirst=C&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integration of Genomics with Traditional Toxicology T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39904007; 4145287 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Boorman, G Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Integration KW - Genomics KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39904007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Integration+of+Genomics+with+Traditional+Toxicology&rft.au=Boorman%2C+G&rft.aulast=Boorman&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fertilization Rate and Oocyte Quality is Adversely Affected Following Neonatal Exposure to the Phytoestrogen Genistein T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39903591; 4145718 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jefferson, W N AU - Padilla-Banks, E AU - Goulding, E H AU - Eddy, E M AU - Newbold, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Oocytes KW - Phytoestrogens KW - Genistein KW - Neonates KW - Fertilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Fertilization+Rate+and+Oocyte+Quality+is+Adversely+Affected+Following+Neonatal+Exposure+to+the+Phytoestrogen+Genistein&rft.au=Jefferson%2C+W+N%3BPadilla-Banks%2C+E%3BGoulding%2C+E+H%3BEddy%2C+E+M%3BNewbold%2C+R+R&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploiting Phenotypic Anchoring to Reveal Gene Expression Indicators of Incipient Toxicity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39902050; 4145966 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Gene expression KW - Anchoring KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Exploiting+Phenotypic+Anchoring+to+Reveal+Gene+Expression+Indicators+of+Incipient+Toxicity&rft.au=Paules%2C+R+S&rft.aulast=Paules&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicokinetic Profile of Batracylin in Beagle Dogs T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901966; 4145953 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Jia, L AU - Tomaszewski, J E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Toxicokinetic+Profile+of+Batracylin+in+Beagle+Dogs&rft.au=Jia%2C+L%3BTomaszewski%2C+J+E&rft.aulast=Jia&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Differential Gene Expression in Blood and Liver of Lipopolysaccharide Treated Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901656; 4144879 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Fannin, R D AU - Auman, J T AU - Bruno, M E AU - Sieber, S O AU - Tucker, C J AU - Merrick, B A AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Blood KW - Liver KW - Rats KW - Gene expression KW - Lipopolysaccharides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparison+of+Differential+Gene+Expression+in+Blood+and+Liver+of+Lipopolysaccharide+Treated+Rats&rft.au=Fannin%2C+R+D%3BAuman%2C+J+T%3BBruno%2C+M+E%3BSieber%2C+S+O%3BTucker%2C+C+J%3BMerrick%2C+B+A%3BPaules%2C+R+S&rft.aulast=Fannin&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unique Execution of NO-Mediated Toxicity within Naive and NGF-Differentiated PC12 Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39901273; 4144784 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Brynczka, C AU - Merrick, B Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Pheochromocytoma cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Unique+Execution+of+NO-Mediated+Toxicity+within+Naive+and+NGF-Differentiated+PC12+Cells&rft.au=Brynczka%2C+C%3BMerrick%2C+B&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selection of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Non-Target Tissue T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39897998; 4144891 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Auman, J T AU - Chou, J AU - Gerrish, K AU - Huang, Q AU - Jayadev, S AU - Blanchard, K T AU - Paules, R S Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Hepatotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Selection+of+Genes+Implicated+in+Methapyrilene-Induced+Hepatotoxicity+by+Comparing+Differential+Gene+Expression+in+Target+and+Non-Target+Tissue&rft.au=Auman%2C+J+T%3BChou%2C+J%3BGerrish%2C+K%3BHuang%2C+Q%3BJayadev%2C+S%3BBlanchard%2C+K+T%3BPaules%2C+R+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Antiretroviral Zidovudine Alters the Cell Cycle and Induces Metabolic Resistance in Human Lymphoblastoid Cells Exposed Long-Term In Vitro T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39896601; 4145751 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Olivero, O AU - Ming, J M AU - Vazquez, I L AU - Robinson, E J AU - Poirier, M C Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Antiretroviral agents KW - Cell cycle KW - Zidovudine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Antiretroviral+Zidovudine+Alters+the+Cell+Cycle+and+Induces+Metabolic+Resistance+in+Human+Lymphoblastoid+Cells+Exposed+Long-Term+In+Vitro&rft.au=Olivero%2C+O%3BMing%2C+J+M%3BVazquez%2C+I+L%3BRobinson%2C+E+J%3BPoirier%2C+M+C&rft.aulast=Olivero&rft.aufirst=O&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposure to Environmental Estrogens During Development is Associated with Obesity Later in Life T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39893288; 4144338 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Newbold, R AU - Padilla-Banks, E AU - Snyder, R AU - Jefferson, W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Obesity KW - Estrogens KW - Sex hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Exposure+to+Environmental+Estrogens+During+Development+is+Associated+with+Obesity+Later+in+Life&rft.au=Newbold%2C+R%3BPadilla-Banks%2C+E%3BSnyder%2C+R%3BJefferson%2C+W&rft.aulast=Newbold&rft.aufirst=R&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Arsenic with Human Prostate Progenitor Cells T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39883281; 4145671 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tokar, E J AU - Qu, W. AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Arsenic KW - Prostate KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Interactions+of+Arsenic+with+Human+Prostate+Progenitor+Cells&rft.au=Tokar%2C+E+J%3BQu%2C+W.%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Tokar&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - WormTox: Toxicological Screening Tools Using the Nematode Caenorhabditis Elegans T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39871048; 4145317 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Boyd, W AU - McBride, S AU - Rice, J AU - Snyder, D AU - Freedman, J Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Screening KW - Nematoda KW - Caenorhabditis elegans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39871048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=WormTox%3A+Toxicological+Screening+Tools+Using+the+Nematode+Caenorhabditis+Elegans&rft.au=Boyd%2C+W%3BMcBride%2C+S%3BRice%2C+J%3BSnyder%2C+D%3BFreedman%2C+J&rft.aulast=Boyd&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Gene Expression Associated with Exposure to Environmental Toxicants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870821; 4144959 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Freedman, J H AU - Chen, M AU - Coughlan, S AU - Boyd, W A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicants KW - Gene expression KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Changes+in+Gene+Expression+Associated+with+Exposure+to+Environmental+Toxicants&rft.au=Freedman%2C+J+H%3BChen%2C+M%3BCoughlan%2C+S%3BBoyd%2C+W+A&rft.aulast=Freedman&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nuclear Receptor CAR Regulates Dio1 and Alters Thyroid Hormone Activity in Regenerating Liver T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870596; 4145185 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tien, E AU - Negishi, M AU - Matsui, K AU - Moore, R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Liver KW - Hormones KW - Nuclear receptors KW - Thyroid hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Nuclear+Receptor+CAR+Regulates+Dio1+and+Alters+Thyroid+Hormone+Activity+in+Regenerating+Liver&rft.au=Tien%2C+E%3BNegishi%2C+M%3BMatsui%2C+K%3BMoore%2C+R&rft.aulast=Tien&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Urogenital Carcinogenesis in Female CD1 Mice Induced by In Utero Arsenic Exposure is Enhanced by Postnatal Diethylstilbestrol Treatment T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870473; 4145673 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Waalkes, M P AU - Liu, J AU - Ward, J M AU - Powell, D A AU - Diwan, B A Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Mice KW - Arsenic KW - Carcinogenesis KW - Intrauterine exposure KW - Diethylstilbestrol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Urogenital+Carcinogenesis+in+Female+CD1+Mice+Induced+by+In+Utero+Arsenic+Exposure+is+Enhanced+by+Postnatal+Diethylstilbestrol+Treatment&rft.au=Waalkes%2C+M+P%3BLiu%2C+J%3BWard%2C+J+M%3BPowell%2C+D+A%3BDiwan%2C+B+A&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemangiosarcomas Induced in Mice By N-(4-Hydroxyphenyl) Retinamide T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870297; 4146422 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Crowell, J A AU - Goldenthal, E I Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Hemangiosarcomas+Induced+in+Mice+By+N-%284-Hydroxyphenyl%29+Retinamide&rft.au=Crowell%2C+J+A%3BGoldenthal%2C+E+I&rft.aulast=Crowell&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disposition of a Mixture of Polybrominated Diphenyl Ethers (PBDES) in Male F344 Rats T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39870094; 4145563 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Lebetkin, E H AU - Sanders, J M AU - Chen, L AU - Creech, A C AU - Burka, L T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Polybrominated diphenyl ethers KW - Rats KW - Disposition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Disposition+of+a+Mixture+of+Polybrominated+Diphenyl+Ethers+%28PBDES%29+in+Male+F344+Rats&rft.au=Lebetkin%2C+E+H%3BSanders%2C+J+M%3BChen%2C+L%3BCreech%2C+A+C%3BBurka%2C+L+T&rft.aulast=Lebetkin&rft.aufirst=E&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered S-Adenosylmethionine Metabolism and Glutathione Production in the Early Stages of Chronic Arsenic Exposure in Human Prostate Epithelial Cells: Implications in Arsenic Adaptation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39869764; 4145672 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Coppin, J AU - Benbrahim-Tallaa, L AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Heavy metals KW - Arsenic KW - Metabolism KW - Adaptations KW - Epithelial cells KW - Prostate KW - Glutathione KW - S-Adenosylmethionine KW - Coenzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Altered+S-Adenosylmethionine+Metabolism+and+Glutathione+Production+in+the+Early+Stages+of+Chronic+Arsenic+Exposure+in+Human+Prostate+Epithelial+Cells%3A+Implications+in+Arsenic+Adaptation&rft.au=Coppin%2C+J%3BBenbrahim-Tallaa%2C+L%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Coppin&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respiratory Tract Toxicity of Diacetyl in C57Bl/6 Mice T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39860475; 4144813 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Morgan, D L AU - Flake, G AU - Kirby, P J AU - Burka, L T AU - Kleeberger, S R AU - Garantziotis, S AU - Germolec, D R AU - Palmer, S M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Mice KW - Respiratory tract KW - Diacetyl KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Respiratory+Tract+Toxicity+of+Diacetyl+in+C57Bl%2F6+Mice&rft.au=Morgan%2C+D+L%3BFlake%2C+G%3BKirby%2C+P+J%3BBurka%2C+L+T%3BKleeberger%2C+S+R%3BGarantziotis%2C+S%3BGermolec%2C+D+R%3BPalmer%2C+S+M&rft.aulast=Morgan&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulating the Genome with Chromatin and Epigenetic Changes T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39859686; 4146709 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Archer, T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Genomes KW - Chromatin KW - Epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Regulating+the+Genome+with+Chromatin+and+Epigenetic+Changes&rft.au=Archer%2C+T&rft.aulast=Archer&rft.aufirst=T&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequential Phosphorylation by Protein Kinase CK2 Regulates NRF2 Activation and Degradation: Potential Role in Arsenic-Induced Skin Carcinogenesis T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858650; 4145335 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Pi, J. AU - Diwan, B A AU - Qu, W. AU - Liu, J AU - Bai, Y AU - Fahl, W AU - Yamauchi, H AU - Collins, S AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Skin KW - Carcinogenesis KW - Casein kinase II KW - Phosphorylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Sequential+Phosphorylation+by+Protein+Kinase+CK2+Regulates+NRF2+Activation+and+Degradation%3A+Potential+Role+in+Arsenic-Induced+Skin+Carcinogenesis&rft.au=Pi%2C+J.%3BDiwan%2C+B+A%3BQu%2C+W.%3BLiu%2C+J%3BBai%2C+Y%3BFahl%2C+W%3BYamauchi%2C+H%3BCollins%2C+S%3BWaalkes%2C+M+P&rft.aulast=Pi&rft.aufirst=J.&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Animal Use in Acute Systemic Toxicity Testing by Using In Vitro Cytotoxicity Assays for Estimating Starting Doses T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858576; 4146408 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Strickland, J A AU - Paris, M W AU - Casati, S AU - Tice, R R AU - Stokes, W S AU - Lee, R AU - Harvey, E AU - Haseman, J AU - Raabe, H AU - Cao, C AU - Clothier, R AU - Mun, G AU - Sizemore, A AU - Moyer, G AU - Madren-Whalley, J AU - Krishna, C AU - Owen, M AU - Bourne, N AU - Wenk, N AU - Vallant, M Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Cytotoxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Reducing+Animal+Use+in+Acute+Systemic+Toxicity+Testing+by+Using+In+Vitro+Cytotoxicity+Assays+for+Estimating+Starting+Doses&rft.au=Strickland%2C+J+A%3BParis%2C+M+W%3BCasati%2C+S%3BTice%2C+R+R%3BStokes%2C+W+S%3BLee%2C+R%3BHarvey%2C+E%3BHaseman%2C+J%3BRaabe%2C+H%3BCao%2C+C%3BClothier%2C+R%3BMun%2C+G%3BSizemore%2C+A%3BMoyer%2C+G%3BMadren-Whalley%2C+J%3BKrishna%2C+C%3BOwen%2C+M%3BBourne%2C+N%3BWenk%2C+N%3BVallant%2C+M&rft.aulast=Strickland&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of the Mechanisms of Toxicity of Polybrominated Diphenyl Ethers (PBDES). T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39858459; 4146371 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Sanders, J M AU - Chen, L AU - Lebetkin, E H AU - Cunningham, M L AU - Burka, L T Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Polybrominated diphenyl ethers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Studies+of+the+Mechanisms+of+Toxicity+of+Polybrominated+Diphenyl+Ethers+%28PBDES%29.&rft.au=Sanders%2C+J+M%3BChen%2C+L%3BLebetkin%2C+E+H%3BCunningham%2C+M+L%3BBurka%2C+L+T&rft.aulast=Sanders&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Pathology of Hemangiosarcoma T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39854217; 4145982 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Malarkey, D E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39854217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Pathology+of+Hemangiosarcoma&rft.au=Malarkey%2C+D+E&rft.aulast=Malarkey&rft.aufirst=D&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Performance of Four in Vitro Test Methods for the Classification of Ocular Corrosives and Severe Irritants T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39810126; 4144858 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Stokes, W S AU - Choksi, N Y AU - Allen, D G AU - Truax, J F AU - Tice, R R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Corrosion KW - Classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39810126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Comparative+Performance+of+Four+in+Vitro+Test+Methods+for+the+Classification+of+Ocular+Corrosives+and+Severe+Irritants&rft.au=Stokes%2C+W+S%3BChoksi%2C+N+Y%3BAllen%2C+D+G%3BTruax%2C+J+F%3BTice%2C+R+R&rft.aulast=Stokes&rft.aufirst=W&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ozone-Induced Exacerbation of Response to Recombinant Cockroach Allergen in a TLR4-Deficient Mouse Model T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39809998; 4144803 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Backus, G S AU - Walker, C R AU - Kleeberger, S R Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Allergens KW - Ozonation KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Ozone-Induced+Exacerbation+of+Response+to+Recombinant+Cockroach+Allergen+in+a+TLR4-Deficient+Mouse+Model&rft.au=Backus%2C+G+S%3BWalker%2C+C+R%3BKleeberger%2C+S+R&rft.aulast=Backus&rft.aufirst=G&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Toxicity of Indium Phosphide Particulate in B6C3F1 Mice After Oropharyngeal Aspiration T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39809716; 4144756 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Kirby, P J AU - Shines1, C. J. AU - Price, H C AU - Taylor, G AU - Everitt, J AU - Hill, G AU - Morgan, D L Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity KW - Particulates KW - Indium KW - Mice KW - Lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Pulmonary+Toxicity+of+Indium+Phosphide+Particulate+in+B6C3F1+Mice+After+Oropharyngeal+Aspiration&rft.au=Kirby%2C+P+J%3BShines1%2C+C.+J.%3BPrice%2C+H+C%3BTaylor%2C+G%3BEveritt%2C+J%3BHill%2C+G%3BMorgan%2C+D+L&rft.aulast=Kirby&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of the Di-(2-Ethylhexyl)Phthalate (Dehp) Noael for Reproductive Development in the Rat: Importance of Retention Of Extra F1 Animals. T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39807821; 4146611 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Foster, P M AU - Bishop, J AU - Chapin, R E AU - Kissling, G E AU - Wolfe, G W Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Determination+of+the+Di-%282-Ethylhexyl%29Phthalate+%28Dehp%29+Noael+for+Reproductive+Development+in+the+Rat%3A+Importance+of+Retention+Of+Extra+F1+Animals.&rft.au=Foster%2C+P+M%3BBishop%2C+J%3BChapin%2C+R+E%3BKissling%2C+G+E%3BWolfe%2C+G+W&rft.aulast=Foster&rft.aufirst=P&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Over-Expression of Dnmt3B is Sufficient for Global and Gene Specific DNA Hypermethylation During Cadmium-Induced Malignant Transformation T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39806628; 4146474 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Benbrahim-Tallaa, L AU - Coppin, J AU - Webber, M M AU - Waalkes, M P Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Transformation KW - Overexpression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=Selective+Over-Expression+of+Dnmt3B+is+Sufficient+for+Global+and+Gene+Specific+DNA+Hypermethylation+During+Cadmium-Induced+Malignant+Transformation&rft.au=Benbrahim-Tallaa%2C+L%3BCoppin%2C+J%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=L&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of an In Vitro Screening Assays to Predict Human Sensitivity T2 - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AN - 39805146; 4146005 JF - 45th Annual Meeting of the Society of Toxicology (SOT 2006) AU - Tomaszewski, J E Y1 - 2006/03/05/ PY - 2006 DA - 2006 Mar 05 KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39805146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.atitle=The+Use+of+an+In+Vitro+Screening+Assays+to+Predict+Human+Sensitivity&rft.au=Tomaszewski%2C+J+E&rft.aulast=Tomaszewski&rft.aufirst=J&rft.date=2006-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2006/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - One-time General Consent for Research on Biological Samples AN - 57196111; 200609983 AB - Clinicians and clinical researchers routinely obtain human biological samples and store them for future research. Previously, samples were often stored and used without informed consent. Most investigators thought that the protections in place for research with human participants were not needed for research with human samples. Recent commentators recognise the importance of informed consent for research with biological samples, but they disagree about when it is required and what types of consent should be obtained. Some argue that people should provide consent for each new study, at the time the study is proposed. Others support prospective consent, but they endorse different sets of options regarding the storage of samples, which investigators can use the samples, and what types of research can be performed. This profusion of guidance has led to divergent practices, with one study finding that institutional review boards in the United States recommend "various consent options, all of which are different'. Such variation may undermine the scientific value of patients' contributed samples and greatly increase the costs of such research. Assessing whether people's views support one of the recommended options for consent could provide a solution to these problems. 1 Table, 32 References. P. Broxis JF - BMJ (British Medical Journal) AU - Wendler, David AD - Dept Clinical Bioethics, NIH Clinical Center, Bethesda, MD dwendler@nih.gov Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 SP - 544 EP - 547 PB - British Medical Association, BMJ Publishing Group, London UK VL - 332 IS - 7540 SN - 0959-535X, 0959-535X KW - Evaluative research KW - Consent KW - Biological materials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57196111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=One-time+General+Consent+for+Research+on+Biological+Samples&rft.au=Wendler%2C+David&rft.aulast=Wendler&rft.aufirst=David&rft.date=2006-03-04&rft.volume=332&rft.issue=7540&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.332.7540.544 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Biological materials; Evaluative research; Consent DO - http://dx.doi.org/10.1136/bmj.332.7540.544 ER - TY - CPAPER T1 - Psychiatric Disorders in a Palliative Care Unit T2 - 14th European Congress of Psychiatry AN - 39899240; 4166267 JF - 14th European Congress of Psychiatry AU - Muniz, P S AU - Campos, F C AU - Nardi, A E Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+European+Congress+of+Psychiatry&rft.atitle=Psychiatric+Disorders+in+a+Palliative+Care+Unit&rft.au=Muniz%2C+P+S%3BCampos%2C+F+C%3BNardi%2C+A+E&rft.aulast=Muniz&rft.aufirst=P&rft.date=2006-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+European+Congress+of+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aep2006/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Refractory Pain-Depression Syndrome Treated with Tianeptine T2 - 14th European Congress of Psychiatry AN - 39890258; 4165746 JF - 14th European Congress of Psychiatry AU - Muniz, P S AU - Nardi, A E Y1 - 2006/03/04/ PY - 2006 DA - 2006 Mar 04 KW - Tianeptine KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39890258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+European+Congress+of+Psychiatry&rft.atitle=Refractory+Pain-Depression+Syndrome+Treated+with+Tianeptine&rft.au=Muniz%2C+P+S%3BNardi%2C+A+E&rft.aulast=Muniz&rft.aufirst=P&rft.date=2006-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+European+Congress+of+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aep2006/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. AN - 67691974; 16380375 AB - RecQ helicases are believed to function in repairing replication forks stalled by DNA damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of damaged DNA, thus permitting repair to occur. Since little is known regarding the effects of DNA damage on RecQ helicases, and because the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of damaged DNA associated with the replication fork, we examined the effects of specific bulky, covalent adducts at N(6) of deoxyadenosine (dA) or N(2) of deoxyguanosine (dG) on Werner (WRN) syndrome helicase activity. The adducts are derived from the optically active 7,8-diol 9,10-epoxide (DE) metabolites of the carcinogen benzo[a]pyrene (BaP). The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand. These adducts either occupy the minor groove without significant perturbation of DNA structure (trans adducts) or cause base displacement at the adduct site (cis adducts). In contrast, helicase activity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helical structure. This differs from our previous observation that intercalating dA adducts derived from benzo[c]phenanthrene (BcPh) DEs inhibit WRN activity in a strand- and stereospecific manner. Partial unwinding of the DNA helix at BaP DE-dA adduct sites may make such adducted DNAs more susceptible to the action of helicase than DNA containing the corresponding BcPh DE-dA adducts, which cause little or no destabilization of duplex DNA. The single-stranded DNA binding protein RPA, an auxiliary factor for WRN helicase, enabled the DNA unwinding enzyme to overcome inhibition by either the trans-R or cis-R BaP DE-dG adduct, suggesting that WRN and RPA may function together to unwind duplex DNA harboring specific covalent adducts that otherwise block WRN helicase acting alone. JF - The Journal of biological chemistry AU - Choudhary, Saba AU - Doherty, Kevin M AU - Handy, Christopher J AU - Sayer, Jane M AU - Yagi, Haruhiko AU - Jerina, Donald M AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health/DHHS, Baltimore, MD 21224, USA. Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 SP - 6000 EP - 6009 VL - 281 IS - 9 SN - 0021-9258, 0021-9258 KW - DNA Adducts KW - 0 KW - Deoxyadenosines KW - Dihydroxydihydrobenzopyrenes KW - Epoxy Compounds KW - Replication Protein A KW - DNA KW - 9007-49-2 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Molecular Structure KW - Animals KW - DNA Damage KW - DNA -- metabolism KW - Deoxyadenosines -- chemistry KW - Deoxyadenosines -- metabolism KW - Deoxyguanosine -- chemistry KW - Nucleic Acid Conformation KW - Deoxyguanosine -- metabolism KW - DNA -- chemistry KW - DNA Replication KW - DNA Helicases -- metabolism KW - DNA Helicases -- antagonists & inhibitors KW - Epoxy Compounds -- metabolism KW - Epoxy Compounds -- chemistry KW - Dihydroxydihydrobenzopyrenes -- chemistry KW - Replication Protein A -- metabolism KW - Dihydroxydihydrobenzopyrenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67691974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Inhibition+of+Werner+syndrome+helicase+activity+by+benzo%5Ba%5Dpyrene+diol+epoxide+adducts+can+be+overcome+by+replication+protein+A.&rft.au=Choudhary%2C+Saba%3BDoherty%2C+Kevin+M%3BHandy%2C+Christopher+J%3BSayer%2C+Jane+M%3BYagi%2C+Haruhiko%3BJerina%2C+Donald+M%3BBrosh%2C+Robert+M&rft.aulast=Choudhary&rft.aufirst=Saba&rft.date=2006-03-03&rft.volume=281&rft.issue=9&rft.spage=6000&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Role of Innate Immunity in Suppression of Allergic Inflammation by Ascaris Suum Antigens T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39952701; 4147729 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Boesen, A AU - Wetzel, B AU - Norris, H AU - Bundoc, V AU - Urban, J AU - Keane-Myers, A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Immunity KW - Inflammation KW - Antigens KW - Ascaris suum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=The+Role+of+Innate+Immunity+in+Suppression+of+Allergic+Inflammation+by+Ascaris+Suum+Antigens&rft.au=Boesen%2C+A%3BWetzel%2C+B%3BNorris%2C+H%3BBundoc%2C+V%3BUrban%2C+J%3BKeane-Myers%2C+A&rft.aulast=Boesen&rft.aufirst=A&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pilot Study of Omalizumab (anti-IgE) in Eosinophilic Gastroenteritis T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39952244; 4147802 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Foroughi, S AU - Mannon, P J AU - Bernardino, L B AU - Foster, B AU - Scott, L M AU - Metcalfe, D D AU - Prussin, C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Gastroenteritis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39952244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Pilot+Study+of+Omalizumab+%28anti-IgE%29+in+Eosinophilic+Gastroenteritis&rft.au=Foroughi%2C+S%3BMannon%2C+P+J%3BBernardino%2C+L+B%3BFoster%2C+B%3BScott%2C+L+M%3BMetcalfe%2C+D+D%3BPrussin%2C+C&rft.aulast=Foroughi&rft.aufirst=S&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoimmune Lymphoproliferative Syndrome Caused by Defects in Mitochondria-Mediated Apoptotic Pathways T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39939966; 4147234 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Oliveira, J B AU - Lenardo, M J AU - Fleisher, T A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mitochondria KW - Apoptosis KW - Defects KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39939966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Autoimmune+Lymphoproliferative+Syndrome+Caused+by+Defects+in+Mitochondria-Mediated+Apoptotic+Pathways&rft.au=Oliveira%2C+J+B%3BLenardo%2C+M+J%3BFleisher%2C+T+A&rft.aulast=Oliveira&rft.aufirst=J&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FceR1 and Toll-Like Receptors Mediate Synergistic Signals to Markedly Augment Production of Inflammatory Cytokines in Murine Mast Cells T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39926923; 4147742 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Qiao, H AU - Beaven, M A Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mast cells KW - Cytokines KW - Inflammation KW - Toll-like receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=FceR1+and+Toll-Like+Receptors+Mediate+Synergistic+Signals+to+Markedly+Augment+Production+of+Inflammatory+Cytokines+in+Murine+Mast+Cells&rft.au=Qiao%2C+H%3BBeaven%2C+M+A&rft.aulast=Qiao&rft.aufirst=H&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Regulation of Normal and SLE Plasma Cells by DCC (Deleted in Colon Cancer) and its Ligand Netrin-1 T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39910295; 4146938 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Lugar, P L AU - Slota, R AU - Fischer, R T AU - Withers, D AU - Pisitkun, P AU - Lipsky, P E AU - Grammer, A C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Colon cancer KW - DCC protein KW - Plasma cells KW - Ligands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Functional+Regulation+of+Normal+and+SLE+Plasma+Cells+by+DCC+%28Deleted+in+Colon+Cancer%29+and+its+Ligand+Netrin-1&rft.au=Lugar%2C+P+L%3BSlota%2C+R%3BFischer%2C+R+T%3BWithers%2C+D%3BPisitkun%2C+P%3BLipsky%2C+P+E%3BGrammer%2C+A+C&rft.aulast=Lugar&rft.aufirst=P&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Pathogens and Asthma: A Potential Connection T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39878328; 4147275 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Arbes Jr, S J AU - Cohen, E A AU - Sever, M L AU - Zeldin, D C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Respiratory diseases KW - Asthma KW - Pathogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Oral+Pathogens+and+Asthma%3A+A+Potential+Connection&rft.au=Arbes+Jr%2C+S+J%3BCohen%2C+E+A%3BSever%2C+M+L%3BZeldin%2C+D+C&rft.aulast=Arbes+Jr&rft.aufirst=S&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serotonin Induces Mast Cell Adhesion and Chemotaxis through the 5-HT1A Receptor T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39877625; 4147123 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Kushnir-Sukhov, N M AU - Gilfillan, A M AU - Coleman, J W AU - Toth, M AU - Bruening, S AU - Metcalfe, D D Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Mast cells KW - Serotonin S1 receptors KW - Chemotaxis KW - Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Serotonin+Induces+Mast+Cell+Adhesion+and+Chemotaxis+through+the+5-HT1A+Receptor&rft.au=Kushnir-Sukhov%2C+N+M%3BGilfillan%2C+A+M%3BColeman%2C+J+W%3BToth%2C+M%3BBruening%2C+S%3BMetcalfe%2C+D+D&rft.aulast=Kushnir-Sukhov&rft.aufirst=N&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cockroach Allergen Reduction by Extermination Alone in Low-Income, Urban Homes-A Randomized Control Trial T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39869363; 4146970 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Sever, M AU - Arbes Jr, S J AU - Gore, J C AU - Santangelo, R G AU - Vaughn, B AU - Mitchell, H AU - Schal, C AU - Zeldin, D C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Socio-economic aspects KW - Allergens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Cockroach+Allergen+Reduction+by+Extermination+Alone+in+Low-Income%2C+Urban+Homes-A+Randomized+Control+Trial&rft.au=Sever%2C+M%3BArbes+Jr%2C+S+J%3BGore%2C+J+C%3BSantangelo%2C+R+G%3BVaughn%2C+B%3BMitchell%2C+H%3BSchal%2C+C%3BZeldin%2C+D+C&rft.aulast=Sever&rft.aufirst=M&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lichenoid Drug Eruption Associated with TNF Inhibitors T2 - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AN - 39860661; 4147663 JF - 2006 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2006) AU - Wilson, T M AU - Louie, G H AU - Rapkiewicz, A V AU - Foster, B AU - Turner, M L AU - Goldbach-Mansky, R AU - Rabin, R L AU - Prussin, C Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Eruptions KW - Drugs KW - Tumor necrosis factor KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.atitle=Lichenoid+Drug+Eruption+Associated+with+TNF+Inhibitors&rft.au=Wilson%2C+T+M%3BLouie%2C+G+H%3BRapkiewicz%2C+A+V%3BFoster%2C+B%3BTurner%2C+M+L%3BGoldbach-Mansky%2C+R%3BRabin%2C+R+L%3BPrussin%2C+C&rft.aulast=Wilson&rft.aufirst=T&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchAdvanc ed&MKey=%7B9A8B4883%2DF89A%2D4186%2DBA8D%2D7CDE6CE1C2C4%7D&AKey={49ACE221-6 B99-48C0-B846-ED9A52CF75BC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology T2 - 2006 Hepatitis Single Topic Conference AN - 39826328; 4094899 JF - 2006 Hepatitis Single Topic Conference AU - Kleiner, David Y1 - 2006/03/03/ PY - 2006 DA - 2006 Mar 03 KW - Pathology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Hepatitis+Single+Topic+Conference&rft.atitle=Pathology&rft.au=Kleiner%2C+David&rft.aulast=Kleiner&rft.aufirst=David&rft.date=2006-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Hepatitis+Single+Topic+Conference&rft.issn=&rft_id=info:doi/ L2 - https://www.aasld.org/eweb/DynamicPage.aspx?webcode=eventsummary&evt_key=3c f16fd0-9b53-4758-8e12-534336848c6c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genes for Diabetes and Obesity (NIDDK Pima Indian Study) T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40148628; 4157372 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Bogardus, Clifton Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Obesity KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40148628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Genes+for+Diabetes+and+Obesity+%28NIDDK+Pima+Indian+Study%29&rft.au=Bogardus%2C+Clifton&rft.aulast=Bogardus&rft.aufirst=Clifton&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subcutaneous and Visceral Adipose Tissue Compartments and Association with 21 Metabolic Risk Factors: The Framingham Heart Study T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40102549; 4157348 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Fox, Caroline S AU - Massaro, Joseph M AU - Hoffmann, Udo AU - Maurovich-Horvat, Pal AU - Vasan, Ramachandran S AU - Meigs, James B AU - O'Donnell, Christopher J Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Adipose tissue KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40102549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+Compartments+and+Association+with+21+Metabolic+Risk+Factors%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BMassaro%2C+Joseph+M%3BHoffmann%2C+Udo%3BMaurovich-Horvat%2C+Pal%3BVasan%2C+Ramachandran+S%3BMeigs%2C+James+B%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abdominal Aortic Calcium as a Risk Factor for Development of Intermittent Claudication: The Framingham Heart Study T2 - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AN - 40099554; 4157607 JF - 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention AU - Levitzky, Yamini S AU - Cupples, L Adrienne AU - Murabito, Joanne M AU - Wilson, Peter W AU - Kiel, Douglas P AU - Kannel, William AU - O'Donnell, Christopher J Y1 - 2006/03/02/ PY - 2006 DA - 2006 Mar 02 KW - Calcium KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.atitle=Abdominal+Aortic+Calcium+as+a+Risk+Factor+for+Development+of+Intermittent+Claudication%3A+The+Framingham+Heart+Study&rft.au=Levitzky%2C+Yamini+S%3BCupples%2C+L+Adrienne%3BMurabito%2C+Joanne+M%3BWilson%2C+Peter+W%3BKiel%2C+Douglas+P%3BKannel%2C+William%3BO%27Donnell%2C+Christopher+J&rft.aulast=Levitzky&rft.aufirst=Yamini&rft.date=2006-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3031496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mass determination of major plasma proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry AN - 954577925; 13860372 AB - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) serves as a rapid and accurate means to determine masses of proteins independent of their shapes or interactions with other molecules. It provides one of the most fundamental characterizations of major plasma proteins. Purified proteins in saline or serum specimens were prepared for analysis by dilution, mixing with a solution of sinapinic acid, and drying on a target plate. Specimens were analyzed in a linear TOF mode with external calibration. Analyses of 24 purified plasma proteins showed predominance of singly charged ions with lesser amounts of dimer and doubly charged monomer, and provided measured masses for these proteins. A number of proteins, including albumin, transferrin, apolipoproteins A-I, A-II, C-I, C-II, and C-III, and prealbumin, could be analyzed directly in serum with appropriate dilution. Measured values for masses of major plasma proteins will assist in analysis of serum and plasma. It is possible to analyze a number of components by MALDI-TOF/MS directly in diluted serum. Extremely simple sample preparation techniques may be useful in analyzing structural variation of several major plasma proteins, particularly those with masses <30 kDa, including a number of apolipoproteins and markers of nutritional status or acute phase responses. JF - Clinical Proteomics AU - Hortin, Glen L AU - Remaley, Alan T AD - Department of Laboratory Medicine, National Institutes of Health, Building 10, Room 2C-407, 20892, Bethesda, MD, ghortin@mail.cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 103 EP - 115 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 2 IS - 1-2 SN - 1542-6416, 1542-6416 KW - Toxicology Abstracts KW - Nutritional status KW - Ions KW - Apolipoproteins KW - sinapinic acid KW - Drying KW - Apolipoprotein A-I KW - Mass spectroscopy KW - Monomers KW - Plasma proteins KW - Transferrin KW - Albumin KW - Lasers KW - proteomics KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954577925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Proteomics&rft.atitle=Mass+determination+of+major+plasma+proteins+by+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometry&rft.au=Hortin%2C+Glen+L%3BRemaley%2C+Alan+T&rft.aulast=Hortin&rft.aufirst=Glen&rft.date=2006-03-01&rft.volume=2&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Clinical+Proteomics&rft.issn=15426416&rft_id=info:doi/10.1385%2FCP%3A2%3A1%3A103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Nutritional status; Ions; Apolipoproteins; sinapinic acid; Drying; Apolipoprotein A-I; Mass spectroscopy; Plasma proteins; Monomers; Transferrin; Albumin; Lasers; proteomics DO - http://dx.doi.org/10.1385/CP:2:1:103 ER - TY - JOUR T1 - Evaluation of cell recycle on Thermomyces lanuginosus xylanase a production by Pichia pastoris GS 115 AN - 860392269; 13858393 AB - This work aims to evaluate cell recycle of a recombinant strain of Pichia pastoris GS115 on the Xylanase A (XynA) production of Thermomyces lanuginosus IOC-4145 in submerged fermentation. Fed-batch processes were carried out with methanol feeding at each 12h and recycling cell at 24, 48, and 72 h. Additionally, the influence of the initial cell concentration was investigated. XynA production was not decreased with the recycling time, during four cell recycles, using an initial cell concentration of 2.5 g/L. The maximum activity was 14,050 U/L obtained in 24h of expression. However, when the initial cell concentration of 0.25 g/L was investigated, the enzymatic activity was reduced by 30 and 75% after the third and fourth cycles, respectively. Finally, it could be concluded that the initial cell concentration influenced the process performance and the interval of cell recycle affected enzymatic production. JF - Applied Biochemistry and Biotechnology AU - Ferreira, Veronica AU - Nolasco, Patricia C AU - Castro, Aline M AU - Silva, Juliana NC AU - Santos, Alexandre S AU - Damaso, Monica CT AU - Pereira, Nei AD - Escola de Quimica-Universidade Federal do Rio de Janeiro, Caixa Postal 68542, CEP 21945-970, Rio de Janeiro, RJ, Brazil, nei@eq.ufri.br Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 226 EP - 233 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 129 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Feeding KW - Xylan endo-1,3-b-xylosidase KW - Fermentation KW - Methanol KW - Thermomyces lanuginosus KW - XynA protein KW - Enzymatic activity KW - Pichia pastoris KW - Recycling KW - Batch culture KW - Xylan endo-1,3- beta -xylosidase KW - K 03330:Biochemistry KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860392269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Evaluation+of+cell+recycle+on+Thermomyces+lanuginosus+xylanase+a+production+by+Pichia+pastoris+GS+115&rft.au=Ferreira%2C+Veronica%3BNolasco%2C+Patricia+C%3BCastro%2C+Aline+M%3BSilva%2C+Juliana+NC%3BSantos%2C+Alexandre+S%3BDamaso%2C+Monica+CT%3BPereira%2C+Nei&rft.aulast=Ferreira&rft.aufirst=Veronica&rft.date=2006-03-01&rft.volume=129&rft.issue=1-3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A129%3A1%3A226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Feeding; Xylan endo-1,3-b-xylosidase; Fermentation; Methanol; Enzymatic activity; XynA protein; Recycling; Xylan endo-1,3- beta -xylosidase; Batch culture; Thermomyces lanuginosus; Pichia pastoris DO - http://dx.doi.org/10.1385/ABAB:129:1:226 ER - TY - JOUR T1 - RSM analysis of the effects of the oxygen transfer coefficient and inoculum size on the xylitol production by Candida guilliermondii AN - 856760981; 13858396 AB - Biotechnology production of xylitol is an excellent alternative to the industrial chemical process for the production of this polyalcohol. In this work the behavior of Candida guilliermondii yeast was studied when crucial process variables were modified. The K sub(L)a (between 18 and 40/h) and the initial cell mass (between 4 and 10 g) were considered as control variables. A response surface methodology was applied to the experimental design to study the resulting effect when the control variables were modified. A regression model was developed and used to determine an optimal value that was further validated experimentally. The optimal values determined for K sub(L)a and X sub(0) were 32.85/h and 9.86 g, respectively, leading to maximum values for productivity (1.628 g/h) and xylitol yield (0.708 g/g). JF - Applied Biochemistry and Biotechnology AU - Vasquez, Mariana Penuela AU - Bezerra, Mauricio AU - Souza, Souza AU - Pereira, Nei AD - Departamento de Engenharia Bioquimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, CEP 21.949-900, Rio de Janeiro, RJ, Brasil, nei@eq.ufrj.br Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 256 EP - 264 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 129 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Oxygen KW - Xylitol KW - Inoculum KW - Regression analysis KW - Candida guilliermondii KW - K 03330:Biochemistry KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856760981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=RSM+analysis+of+the+effects+of+the+oxygen+transfer+coefficient+and+inoculum+size+on+the+xylitol+production+by+Candida+guilliermondii&rft.au=Vasquez%2C+Mariana+Penuela%3BBezerra%2C+Mauricio%3BSouza%2C+Souza%3BPereira%2C+Nei&rft.aulast=Vasquez&rft.aufirst=Mariana&rft.date=2006-03-01&rft.volume=129&rft.issue=1-3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A129%3A1%3A256 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Oxygen; Xylitol; Regression analysis; Inoculum; Candida guilliermondii DO - http://dx.doi.org/10.1385/ABAB:129:1:256 ER - TY - JOUR T1 - Placebo-controlled study of rTMS for the treatment of Parkinson's disease. AN - 85385719; pmid-16211618 AB - The objective of this study is to assess the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for gait and bradykinesia in patients with Parkinson's disease (PD). In a double-blind placebo-controlled study, we evaluated the effects of 25 Hz rTMS in 18 PD patients. Eight rTMS sessions were performed over a 4-week period. Four cortical targets (left and right motor and dorsolateral prefrontal cortex) were stimulated in each session, with 300 pulses each, 100% of motor threshold intensity. Left motor cortex (MC) excitability was assessed using motor evoked potentials (MEPs) from the abductor pollicis brevis. During the 4 weeks, times for executing walking and complex hand movements tests gradually decreased. The therapeutic rTMS effect lasted for at least 1 month after treatment ended. Right-hand bradykinesia improvement correlated with increased MEP amplitude evoked by left MC rTMS after individual sessions, but improvement overall did not correlate with MC excitability. rTMS sessions appear to have a cumulative benefit for improving gait, as well as reducing upper limb bradykinesia in PD patients. Although short-term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation.(c) 2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Lomarev, Mikhail P AU - Kanchana, Sulada AU - Bara-Jimenez, William AU - Iyer, Meena AU - Wassermann, Eric M AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA. lomarev@ninds.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 325 EP - 331 VL - 21 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Evoked Potentials, Motor: physiology KW - Female KW - Hand: physiopathology KW - Humans KW - Hypokinesia: physiopathology KW - Hypokinesia: therapy KW - Male KW - Middle Aged KW - Motor Cortex: physiopathology KW - Parkinson Disease: diagnosis KW - Parkinson Disease: physiopathology KW - *Parkinson Disease: therapy KW - Prefrontal Cortex: physiopathology KW - Severity of Illness Index KW - *Transcranial Magnetic Stimulation: instrumentation KW - Walking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Placebo-controlled+study+of+rTMS+for+the+treatment+of+Parkinson%27s+disease.&rft.au=Lomarev%2C+Mikhail+P%3BKanchana%2C+Sulada%3BBara-Jimenez%2C+William%3BIyer%2C+Meena%3BWassermann%2C+Eric+M%3BHallett%2C+Mark&rft.aulast=Lomarev&rft.aufirst=Mikhail&rft.date=2006-03-01&rft.volume=21&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth. AN - 85384012; pmid-16500445 AB - To analyze the therapeutic implications of the distribution of neck metastases (NM) in patients with squamous cell carcinoma (SCC) of the tongue and the floor of the mouth (FOM).From January 1987 through December 1997, 339 previously untreated patients with T1-2 N0 M0 SCC of the tongue and the FOM underwent primary surgical treatment in our institution. A retrospective review of the pathology reports and outcome of these patients was made to ascertain the prevalence and distribution of NM. Patients were grouped by clinical neck status at the time of neck dissection: elective neck dissection (END) in the NO neck and subsequent therapeutic dissection (STD) in the neck observed which converted clinically to N+ or regional recurrences after END. All patients were classified according to the American Joint Committee on Cancer (AJCC)/UICC 2002 TNM classification.All patients underwent surgical treatment of the primary cancer and had negative margins at frozen section. Overall incidence of NM was 41.3%. Twenty-seven point eight percent of T1 N0 M0 and 48.2% of T2 N0 M0 patients developed NM (P = .0004). Occult neck metastases occurred in 24.1% of patients. Clinically, N+ metastases occurred in 23.6% of patients. The overall incidence of NM in levels IV and V was 8.5%. Neck level IV nodes were involved in only 1.5% of patients in the END group versus 23.7% in the STD group (P < 0.001). Level V was always associated to nodal metastases in other neck levels. Only 2% of patients in our study presented "skip metastases" in the neck.Neck levels I and II were at great risk for the development of NM (46.9% and 75.3% respectively). Levels IV (6.5%) and V (2%) were rarely involved in our group of patients. The results found in this study support the indication of supraomohyoid neck dissection for N0 and a more comprehensive neck dissection (levels I-V) for N+ patients in Stage I-II SCC of the tongue and FOM. EBM rating: C-4. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Dias, Fernando L AU - Lima, Roberto A AU - Kligerman, Jacob AU - Farias, Terence P AU - Soares, Jose Roberto N AU - Manfro, Gabriel AU - Sa, Geraldo M AD - Department of Head and Neck Surgery, Brazilian National Cancer Institute, Av. Alexandre Ferreira 190, Rio de Janeiro, RJ 22470-220, Brazil. fdias@inca.gov.br Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 460 EP - 465 VL - 134 IS - 3 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Carcinoma, Squamous Cell: pathology KW - *Carcinoma, Squamous Cell: secondary KW - Follow-Up Studies KW - Humans KW - Lymph Nodes: pathology KW - *Lymphatic Metastasis: pathology KW - *Mouth Floor: pathology KW - *Mouth Neoplasms: pathology KW - Neck KW - Neck Dissection KW - Neoplasm Recurrence, Local: pathology KW - Neoplasm Staging KW - Retrospective Studies KW - Surgical Procedures, Elective KW - *Tongue Neoplasms: pathology KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85384012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Relevance+of+skip+metastases+for+squamous+cell+carcinoma+of+the+oral+tongue+and+the+floor+of+the+mouth.&rft.au=Dias%2C+Fernando+L%3BLima%2C+Roberto+A%3BKligerman%2C+Jacob%3BFarias%2C+Terence+P%3BSoares%2C+Jose+Roberto+N%3BManfro%2C+Gabriel%3BSa%2C+Geraldo+M&rft.aulast=Dias&rft.aufirst=Fernando&rft.date=2006-03-01&rft.volume=134&rft.issue=3&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Biosurfactant production by Rhodococcus erythropolis grown on glycerol as sole carbon source AN - 807290978; 13859271 AB - The production of biosurfactant by Rhodococcus erythropolis during the growth on glycerol was investigated. The process was carried out at 28C in a 1.5-L bioreactor using glycerol as carbon source. The bioprocess was monitored through measurements of biosurfactant concentration and glycerol consumption. After 51 h of cultivation, 1.7 g/L of biosurfactant, surface, and interfacial tensions values (with n-hexadecane) of 43 and 15 mN/m, respectively, 67% of Emulsifying Index (E sub(24)), and 94% of oil removal were obtained. The use of glycerol rather than what happens with hydrophobic carbon source allowed the release of the biosurfactant, originally associated to the cell wall. JF - Applied Biochemistry and Biotechnology AU - Ciapina, Elisa MP AU - Melo, Walber C AU - Santa Anna, Lidia MM AU - Santos, Alexandre S AU - Freire, Denise MG AU - Pereira, Nei AD - Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, CEP 21949-900, Rio de Janeiro, RJ, Brasil, nei@eq.ufrj.br Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 880 EP - 886 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 131 IS - 1-3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts KW - Surface tension KW - biosurfactants KW - Hydrophobicity KW - Carbon sources KW - Oil KW - Growth KW - Carbon KW - Glycerol KW - Bioreactors KW - Rhodococcus erythropolis KW - Oil removal KW - Manganese KW - Biotechnology KW - Cell walls KW - Pollution control KW - Q1 08206:Physiology, biochemistry, biophysics KW - W 30950:Waste Treatment & Pollution Clean-up KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807290978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Biosurfactant+production+by+Rhodococcus+erythropolis+grown+on+glycerol+as+sole+carbon+source&rft.au=Ciapina%2C+Elisa+MP%3BMelo%2C+Walber+C%3BSanta+Anna%2C+Lidia+MM%3BSantos%2C+Alexandre+S%3BFreire%2C+Denise+MG%3BPereira%2C+Nei&rft.aulast=Ciapina&rft.aufirst=Elisa&rft.date=2006-03-01&rft.volume=131&rft.issue=1-3&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1385%2FABAB%3A131%3A1%3A880 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Growth; Surface tension; Glycerol; Carbon; Bioreactors; Oil removal; Biotechnology; Pollution control; Cell walls; Oil; Hydrophobicity; biosurfactants; Carbon sources; Manganese; Rhodococcus erythropolis DO - http://dx.doi.org/10.1385/ABAB:131:1:880 ER - TY - JOUR T1 - Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: Acute renal failure is dependent on MyD88 but not renal cell apoptosis AN - 807260170; 13631303 AB - Toll-like receptors (TLRs) are important in sepsis. Myeloid differentiation factor 88 (MyD88) is a key molecule involved in signal transduction by multiple TLRs. The objective of this study was to investigate the contribution of TLR4 and MyD88 to acute renal failure (ARF) induced by polymicrobial sepsis. Liver dysfunction and apoptosis in the spleen contribute to sepsis severity after cecal ligation and puncture (CLP). Therefore, we also investigated liver injury and splenic apoptosis. We used a mouse model of sepsis-induced ARF using CLP to generate polymicrobial sepsis. Despite fluid and antibiotic resuscitation the mice developed multi-organ failure, including ARF, which resembles human sepsis. We investigated the role of the TLR4 receptor by comparing C3H/HeJ mice (which lack TLR4) with C3H/He0UJ normal controls. The role of MyD88 was investigated by comparing MyD88 knockout mice (MyD88 super(-/-)) with wild-type controls. Following CLP, mice lacking TLR4 and wild-type mice both developed comparable ARF. However, MyD88 super(-/-) mice did not develop ARF compared to wild-type controls. In contrast, MyD88 super(-/-) mice developed liver injury comparable to wild type. After CLP, MyD88 super(-/-) mice had significantly reduced apoptosis in the spleen compared with wild type. Apoptosis was not detected in the kidney of wild-type or MyD88 super(-/-) mice after CLP. In summary, ARF induced by polymicrobial sepsis is dependent on MyD88, but not TLR4. The absence of MyD88 dissociates ARF from liver injury; liver injury is MyD88-independent. There was MyD88-dependent apoptosis in the spleen, but no apoptosis in the kidney. MyD88 may be a good drug target for some, but not all, organ dysfunctions following sepsis.Kidney International (2006) 69, 832-836. doi:10.1038/sj.ki.5000165; published online 11 January 2006 JF - Kidney International AU - Dear, J W AU - Yasuda, H AU - Hu, X AU - Hieny, S AU - Yuen, P S T AU - Hewitt, S M AU - Sher, A AU - Star, R A AD - 1 Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, Bethesda, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 832 EP - 836 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 69 IS - 5 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Apoptosis KW - Injuries KW - MyD88 protein KW - Kidney KW - Liver KW - Spleen KW - TLR4 protein KW - Toll-like receptors KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807260170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Sepsis-induced+organ+failure+is+mediated+by+different+pathways+in+the+kidney+and+liver%3A+Acute+renal+failure+is+dependent+on+MyD88+but+not+renal+cell+apoptosis&rft.au=Dear%2C+J+W%3BYasuda%2C+H%3BHu%2C+X%3BHieny%2C+S%3BYuen%2C+P+S+T%3BHewitt%2C+S+M%3BSher%2C+A%3BStar%2C+R+A&rft.aulast=Dear&rft.aufirst=J&rft.date=2006-03-01&rft.volume=69&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fsj.ki.5000165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sepsis; Apoptosis; Injuries; MyD88 protein; Liver; Kidney; Spleen; TLR4 protein; Toll-like receptors DO - http://dx.doi.org/10.1038/sj.ki.5000165 ER - TY - JOUR T1 - Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects. AN - 68921013; 17017365 JF - La Medicina del lavoro AU - Paules, R S AD - Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA. Paules@niehs.nih.gov PY - 2006 SP - 322 EP - 323 VL - 97 IS - 2 SN - 0025-7818, 0025-7818 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Noxae KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - United States KW - Gene Expression Profiling KW - Animals KW - Mutagenicity Tests KW - Liver -- drug effects KW - Humans KW - Liver -- metabolism KW - Organ Specificity KW - Rodentia KW - Acetaminophen -- toxicity KW - Noxae -- adverse effects KW - Noxae -- toxicity KW - Genomics -- methods KW - Biomarkers -- analysis KW - National Institutes of Health (U.S.) -- organization & administration KW - Toxicology -- methods KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68921013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=La+Medicina+del+lavoro&rft.atitle=Toxicogenomics+and+environmental+diseases%3A+the+search+for+biomarkers+predictive+of+adverse+effects.&rft.au=Paules%2C+R+S&rft.aulast=Paules&rft.aufirst=R&rft.date=2006-03-01&rft.volume=97&rft.issue=2&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=La+Medicina+del+lavoro&rft.issn=00257818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is occupational exposure to mineral oil a risk factor for rheumatoid arthritis? AN - 68784597; 16932671 JF - Nature clinical practice. Rheumatology AU - Miller, Frederick W AD - Environmental Autoimmunity Group, National Institutes of Health, DHHS, Clinical Research Center, Bethesda, MD 20892-1301, USA. millerf@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 130 EP - 131 VL - 2 IS - 3 SN - 1745-8382, 1745-8382 KW - Emollients KW - 0 KW - Citrulline KW - 29VT07BGDA KW - Mineral Oil KW - 8020-83-5 KW - Rheumatoid Factor KW - 9009-79-4 KW - Index Medicus KW - Rheumatoid Factor -- blood KW - Humans KW - Seroepidemiologic Studies KW - Aged KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Sweden -- epidemiology KW - Citrulline -- immunology KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Arthritis, Rheumatoid -- epidemiology KW - Occupational Diseases -- blood KW - Arthritis, Rheumatoid -- blood KW - Arthritis, Rheumatoid -- etiology KW - Occupational Diseases -- etiology KW - Mineral Oil -- adverse effects KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Emollients -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68784597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Rheumatology&rft.atitle=Is+occupational+exposure+to+mineral+oil+a+risk+factor+for+rheumatoid+arthritis%3F&rft.au=Miller%2C+Frederick+W&rft.aulast=Miller&rft.aufirst=Frederick&rft.date=2006-03-01&rft.volume=2&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Rheumatology&rft.issn=17458382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-05 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant treatment of high-risk adult soft tissue sarcomas: a survey by the Italian Sarcoma Group. AN - 68008789; 16724686 AB - After the first adjuvant study on adult soft tissue sarcomas was concluded, the participating institutions continued to select and treat patients according to that protocol. The aim of this study was to test the protocol reproducibility when applied as a standard practice. A call for retrospective data was launched in June 1999 (self-referral of consecutive unregistered patients); thereafter, a prospective follow-up was performed. The treatment regimen consisted of epirubicin (60 mg/m2 days 1 and 2), ifosfamide (3 g/m2/die for 3 days) and equimolar doses of 6-mercapto-ethansulfonate (MESNA), with 300 microg G-CSF administered subcutaneously from day +8 until recovery, every 3 weeks for a total of 5 cycles. From November 1996 to June 1999, 55 high-risk, adult patients were treated. The average median dose intensity was 89% of the planned program. Grade 3-4 toxicities were leukopenia (49%), thrombocytopenia (14%), transfusion requiring anemia in 7 patients (16%), and alopecia in all patients (100%). After a median follow-up of 70 months, 23 patients (41.8%) relapsed and 19 died. Median disease-free, local disease-free and overall survival rates have not yet been reached. The disease-free survival rates at 2 and 4 years were 73% and 57%, respectively; the corresponding overall survival rates were 91% and 70%, respectively. The feasibility and reproducibility of the original protocol were confirmed, since disease-specific overall survival and disease-free survival rates at the same period of observation and with the same prolonged follow-up did not differ. JF - Tumori AU - Frustaci, Sergio AU - Berretta, Massimiliano AU - Comandone, Alessandro AU - Bidoli, Ettore AU - De Paoli, Antonino AU - Gherlinzoni, Franco AU - De Pas, Tommaso AU - Barbieri, Enza AU - Pertici, Maurizio AU - Apice, Gaetano AU - Picci, Piero AU - Italian Sarcoma Group AD - Department of Medical Oncology, National Cancer Institute, Aviano. sfrustaci@cro.it ; Italian Sarcoma Group PY - 2006 SP - 92 EP - 97 VL - 92 IS - 2 SN - 0300-8916, 0300-8916 KW - Protective Agents KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Epirubicin KW - 3Z8479ZZ5X KW - Mesna KW - NR7O1405Q9 KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Humans KW - Aged KW - Italy KW - Risk Assessment KW - Feasibility Studies KW - Adult KW - Protective Agents -- therapeutic use KW - Treatment Outcome KW - Epirubicin -- administration & dosage KW - Adolescent KW - Chemotherapy, Adjuvant KW - Male KW - Survival Analysis KW - Alopecia -- chemically induced KW - Ifosfamide -- administration & dosage KW - Drug Administration Schedule KW - Granulocyte Colony-Stimulating Factor -- therapeutic use KW - Neoplasm Staging KW - Reproducibility of Results KW - Hematologic Diseases -- chemically induced KW - Prospective Studies KW - Risk Factors KW - Blood Transfusion KW - Follow-Up Studies KW - Middle Aged KW - Hematologic Diseases -- therapy KW - Female KW - Mesna -- therapeutic use KW - Sarcoma -- surgery KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Sarcoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68008789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tumori&rft.atitle=Adjuvant+treatment+of+high-risk+adult+soft+tissue+sarcomas%3A+a+survey+by+the+Italian+Sarcoma+Group.&rft.au=Frustaci%2C+Sergio%3BBerretta%2C+Massimiliano%3BComandone%2C+Alessandro%3BBidoli%2C+Ettore%3BDe+Paoli%2C+Antonino%3BGherlinzoni%2C+Franco%3BDe+Pas%2C+Tommaso%3BBarbieri%2C+Enza%3BPertici%2C+Maurizio%3BApice%2C+Gaetano%3BPicci%2C+Piero%3BItalian+Sarcoma+Group&rft.aulast=Frustaci&rft.aufirst=Sergio&rft.date=2006-03-01&rft.volume=92&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Tumori&rft.issn=03008916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ETS-TMPRSS2 fusion gene products in prostate cancer. AN - 67956878; 16575200 AB - Genes playing a role in carcinogenesis have often been identified through analysis of recurrent chromosomal rearrangements. Although such rearrangements are well known in leukemias, lymphomas, and sarcomas, they have not been well characterized in carcinomas. In the October 28, 2005 issue of Science, a study by Tomlins et al. uses bioinformatics techniques to identify candidate oncogenic chromosomal changes based on analysis of outlier gene expression. The authors determined that two ETS transcription factors, ERG and ETV1 were outliers in prostate cancer. The group reports recurrent fusions of the 5' untranslated region of the TMPRSS2 gene to ERG and ETV1 in the majority of prostate cancer samples containing the outlier expression. In cell lines containing the fusion gene, androgen appears to play a role in mediating ETS overexpression. This fusion gene product may play an important role in the development, diagnosis, and treatment of prostate cancer. JF - Cancer biology & therapy AU - Ahlers, Christoph M AU - Figg, William D AD - Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 254 EP - 255 VL - 5 IS - 3 SN - 1538-4047, 1538-4047 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67956878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=ETS-TMPRSS2+fusion+gene+products+in+prostate+cancer.&rft.au=Ahlers%2C+Christoph+M%3BFigg%2C+William+D&rft.aulast=Ahlers&rft.aufirst=Christoph&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 67927165; 16649821 AB - To present nationally representative data on the prevalence, correlates, and comorbidity of DSM-IV panic disorder (PAN), including the differentiation between panic with agoraphobia (PDA) and without agoraphobia (PDWA) and agoraphobia without a history of panic disorder (AG). The data were derived from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093). Prevalence, correlates, and comorbidity of PAN, PDA, and PDWA with Axis I and II disorders were determined. Prevalences of 12-month and lifetime PAN were 2.1% and 5.1%. Rates of 12-month and lifetime PDWA were 1.6% and 4.0%, exceeding those of 12-month (0.6%) and lifetime (1.1%) PDA. Rates of 12-month and lifetime AG were extremely low, 0.05% and 0.17%. Being female, Native American, middle-aged, widowed/ separated/divorced, and of low income increased risk, while being Asian, Hispanic, or black decreased risk for PAN, PDA, and PDWA. Individuals with PDA were more likely to seek treatment and had earlier ages at onset and first treatment, longer episodes, and more severe disability, impairment, panic symptomatology, and Axis I and II comorbidity than those with PDWA. PDA may be a more severe variant of PAN. Overrepresentation of PDA in treatment settings reflects increased treatment seeking and the severity of PDA relative to PDWA. The very low prevalence of AG leaves open questions about the meaning of the disorder as a distinct clinical entity as defined in the DSM-IV. JF - The Journal of clinical psychiatry AU - Grant, Bridget F AU - Hasin, Deborah S AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Goldstein, Rise B AU - Smith, Sharon AU - Huang, Boji AU - Saha, Tulshi D AD - Laboratory of Epidemiology and Biometry, Division of Clinical and Biological Intramural Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. bgrant@wilco.niaaa.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 363 EP - 374 VL - 67 IS - 3 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Sex Factors KW - Age of Onset KW - Mental Disorders -- epidemiology KW - Humans KW - Aged KW - Indians, North American -- statistics & numerical data KW - Comorbidity KW - Ethnic Groups -- statistics & numerical data KW - Patient Acceptance of Health Care KW - Risk Factors KW - Adult KW - Health Surveys KW - Middle Aged KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Agoraphobia -- diagnosis KW - Panic Disorder -- epidemiology KW - Agoraphobia -- epidemiology KW - Panic Disorder -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67927165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=The+epidemiology+of+DSM-IV+panic+disorder+and+agoraphobia+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise+B%3BSmith%2C+Sharon%3BHuang%2C+Boji%3BSaha%2C+Tulshi+D&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2006-03-01&rft.volume=67&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Ment Health. 2006 Nov;9(4):114 [17065311] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic transformation and mechanism of action of mononitroso caffeidine- a new interpretation. AN - 67856672; 16611159 AB - Although caffeine is not carcinogenic, its hydrolysed product, caffeidine causes human cancer, possibly through endogenous nitrosation to form mononitroso caffeidine (MNC). MNC undergoes enzymatic demethylation and reacts with cellular nucleophiles, notably DNA, via the formation of a putative imidazole diazonium ion. Its interaction with proteins has not been reported. The present work is based on the hypothesis that some active metabolites of MNC covalently interact with cellular DNA and/or proteins to initiate carcinogenesis. We report here the synthesis of a possible reactive metabolite of MNC, viz., N, 1-methyl-4(N-methyl-N-nitrosamino)-imidazole-5-carboxylic acid (MNIC). Its structure has been determined by uv, ir, nmr and mass spectral analyses and its interaction with egg albumin and human serum protein has been examined by uv and CD spectroscopy. We concluded that metabolic activation of MNC occurs through the formation of MNIC. Avoiding consumption of salted tea or coffee that prevents the intake of caffeidine will possibly eliminate the risk of MNC carcinogenicity. JF - Endocrine, metabolic & immune disorders drug targets AU - Panda, G S AU - Bhattacharya, R K AU - Choudhuri, S K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P.Mukherjee Road, Calcutta-700 026, India. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1 EP - 6 VL - 6 IS - 1 SN - 1871-5303, 1871-5303 KW - Amino Acids KW - 0 KW - Anticarcinogenic Agents KW - Blood Proteins KW - Carcinogens KW - Coffee KW - Nitroimidazoles KW - Tea KW - 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone KW - 131134-91-3 KW - caffeidine KW - 20041-90-1 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Animals KW - Mass Spectrometry KW - Coffee -- chemistry KW - Humans KW - Spectrophotometry, Ultraviolet KW - Carcinogens -- toxicity KW - Blood Proteins -- chemistry KW - Circular Dichroism KW - Tea -- chemistry KW - Mice KW - Nitroimidazoles -- antagonists & inhibitors KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Spectrophotometry, Infrared KW - Amino Acids -- chemistry KW - Biotransformation KW - Nitroimidazoles -- toxicity KW - Male KW - Caffeine -- pharmacokinetics KW - Caffeine -- analogs & derivatives KW - Caffeine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67856672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine%2C+metabolic+%26+immune+disorders+drug+targets&rft.atitle=Metabolic+transformation+and+mechanism+of+action+of+mononitroso+caffeidine-+a+new+interpretation.&rft.au=Panda%2C+G+S%3BBhattacharya%2C+R+K%3BChoudhuri%2C+S+K&rft.aulast=Panda&rft.aufirst=G&rft.date=2006-03-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Endocrine%2C+metabolic+%26+immune+disorders+drug+targets&rft.issn=18715303&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-01 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris. AN - 67799192; 16450379 AB - Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are likely to cause osteolysis. Because multipotent mesenchymal stem cells (MSCs) located adjacent to the implant have an osteoprogenitor function and are critical contributors to osseous tissue integrity, when their functions or activities are compromised, osteolysis will most likely occur. To date, it is not certain or sufficiently confirmed whether MSCs endocytose titanium particles, and if so, whether particulate endocytosis has any effect on cellular responses to wear debris. This study seeks to clarify the phenomenon of titanium endocytosis by human MSCs (hMSCs), and investigates the influence of endocytosis on their activities. hMSCs incubated with commercially pure titanium particles exhibited internalized particles, as observed by scanning electron microscopy and confocal laser scanning microscopy, with time-dependent reduction in the number of extracellular particles. Particulate endocytosis was associated with reduced rates of cellular proliferation and cell-substrate adhesion, suppressed osteogenic differentiation, and increased rate of apoptosis. These cellular effects of exposure to titanium particles were reduced when endocytosis was inhibited by treatment with cytochalasin D, and no significant effect was seen when hMSCs were treated only with conditioned medium obtained from particulate-treated cells. These findings strongly suggest that the biological responses of hMSCs to wear debris are triggered primarily by the direct endocytosis of titanium particulates, and not mediated by secreted soluble factors. In this manner, therapeutical approaches that suppress particle endocytosis could reduce the bioreactivity of hMSCs to particulates, and enhance long-term orthopedic implant prognosis by minimizing wear-debris periprosthethic osteolysis. Copyright 2006 Orthopaedic Research Society. JF - Journal of orthopaedic research : official publication of the Orthopaedic Research Society AU - Okafor, Chukwuka C AU - Haleem-Smith, Hana AU - Laqueriere, Patrice AU - Manner, Paul A AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC8022, Department of Health and Human Services, Bethesda, Maryland 20892-8022, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 461 EP - 473 VL - 24 IS - 3 SN - 0736-0266, 0736-0266 KW - Cytochalasin D KW - 22144-77-0 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Osteolysis KW - Cell Proliferation -- drug effects KW - Microscopy, Confocal KW - Humans KW - Arthroplasty, Replacement -- methods KW - Cells, Cultured KW - Apoptosis -- drug effects KW - Arthroplasty, Replacement -- adverse effects KW - Cytochalasin D -- pharmacology KW - Osteogenesis -- drug effects KW - Cell Adhesion -- drug effects KW - Cell Differentiation -- drug effects KW - Arthroplasty, Replacement -- instrumentation KW - Mesenchymal Stromal Cells -- ultrastructure KW - Mesenchymal Stromal Cells -- drug effects KW - Titanium -- adverse effects KW - Joint Prosthesis -- adverse effects KW - Endocytosis -- drug effects KW - Titanium -- metabolism KW - Mesenchymal Stromal Cells -- metabolism KW - Endocytosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67799192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.atitle=Particulate+endocytosis+mediates+biological+responses+of+human+mesenchymal+stem+cells+to+titanium+wear+debris.&rft.au=Okafor%2C+Chukwuka+C%3BHaleem-Smith%2C+Hana%3BLaqueriere%2C+Patrice%3BManner%2C+Paul+A%3BTuan%2C+Rocky+S&rft.aulast=Okafor&rft.aufirst=Chukwuka&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.issn=07360266&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deliberate self-harm and childhood hyperactivity in junior high school students. AN - 67794381; 16447027 AB - The present study aimed to explore the status of deliberate self-harm (DSH) among junior high-school students, and investigate the relationship between DSH and substance use and childhood hyperactivity. Subjects were 239 boys (mean age = 14.16 years, SD = 0.67) and 238 girls (14.22, 0.68) from a junior high-school in Kanagawa, Japan. A self-reporting questionnaire consisting of original questions on self-cutting, self-hitting, and tobacco and alcohol use was employed with the Wender Utah Rating Scale (WURS) for assessing childhood hyperactivity. Overall, 8.00% and 27.70% of males and 9.30% and 12.20% of females reported self-cutting and self-hitting, respectively. Regarding substance use, 33.10% and 74.10% of males and 14.30% and 63.40% of females reported tobacco and alcohol use, respectively. Comparisons of WURS scores between those with and without experience of problematic behaviors revealed that with all problematic behaviors in both genders, scores of those with experience were significantly higher than those without (P < 0.01 except for self-cutting in females, P < 0.05). The present study indicated that DSH is an important problem, even among children as young as junior high-school age. An association between DSH and childhood hyperactivity was also suggested. JF - European child & adolescent psychiatry AU - Izutsu, Takashi AU - Shimotsu, Sakie AU - Matsumoto, Toshihiko AU - Okada, Takayuki AU - Kikuchi, Akiko AU - Kojimoto, Miwa AU - Noguchi, Hirofumi AU - Yoshikawa, Kazuo AD - Dept. of Forensic Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187, Japan. izutsu@gakushikai.jp Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 172 EP - 176 VL - 15 IS - 3 SN - 1018-8827, 1018-8827 KW - Index Medicus KW - Schools KW - Humans KW - Surveys and Questionnaires KW - Sex Distribution KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Attention Deficit Disorder with Hyperactivity -- epidemiology KW - Students -- statistics & numerical data KW - Self-Injurious Behavior -- epidemiology KW - Intention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67794381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+child+%26+adolescent+psychiatry&rft.atitle=Deliberate+self-harm+and+childhood+hyperactivity+in+junior+high+school+students.&rft.au=Izutsu%2C+Takashi%3BShimotsu%2C+Sakie%3BMatsumoto%2C+Toshihiko%3BOkada%2C+Takayuki%3BKikuchi%2C+Akiko%3BKojimoto%2C+Miwa%3BNoguchi%2C+Hirofumi%3BYoshikawa%2C+Kazuo&rft.aulast=Izutsu&rft.aufirst=Takashi&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=European+child+%26+adolescent+psychiatry&rft.issn=10188827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-27 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions. AN - 67775412; 16553875 AB - We previously reported that Chlamydia trachomatis expresses the genes encoding tryptophan synthase (trpBA) and the tryptophan repressor (trpR). Here we employ primer extension analysis to identify the transcriptional origins of both trpR and trpBA, allowing for the identification of the putative operator sequences for both trpR and trpBA. Moreover we demonstrate that native recombinant chlamydial TrpR binds to the predicted operator sequence upstream of trpR. A restriction endonuclease protection assay was designed and used to demonstrate that 5-fluorotryptophan was the only tryptophan analogue capable of activating binding of native recombinant chlamydial TrpR to its operator. Additionally, 5-fluorotryptophan was the only analogue that repressed expression of trpBA at a level analogous to L-tryptophan itself. Based on these findings, a mutant selection protocol was designed and a C. trachomatis isolate containing a frameshift mutation in trpR was isolated. This chlamydial mutant synthesizes a truncated TrpR protein that cannot regulate expression of trpBA and trpR in response to changes in tryptophan levels. These findings provide the first genetic proof that TrpR acts as a negative regulator of transcription in C. trachomatis. JF - Molecular microbiology AU - Carlson, John H AU - Wood, Heidi AU - Roshick, Christine AU - Caldwell, Harlan D AU - McClarty, Grant AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, MT 59840, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1678 EP - 1691 VL - 59 IS - 6 SN - 0950-382X, 0950-382X KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - Repressor Proteins KW - TRPR protein, E coli KW - 5-fluorotryptophan KW - 343-91-9 KW - Tryptophan KW - 8DUH1N11BX KW - Tryptophan Synthase KW - EC 4.2.1.20 KW - Index Medicus KW - Gene Expression -- drug effects KW - Tryptophan -- pharmacology KW - Tryptophan -- analogs & derivatives KW - Base Sequence KW - Molecular Sequence Data KW - DNA, Bacterial -- metabolism KW - Amino Acid Sequence KW - Tryptophan -- metabolism KW - Tryptophan Synthase -- genetics KW - Mutation KW - Mutagenesis KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- genetics KW - Chlamydia trachomatis -- metabolism KW - Operator Regions, Genetic KW - Repressor Proteins -- metabolism KW - Bacterial Proteins -- metabolism KW - Chlamydia trachomatis -- drug effects KW - Regulon -- genetics KW - Chlamydia trachomatis -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67775412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=In+vivo+and+in+vitro+studies+of+Chlamydia+trachomatis+TrpR%3ADNA+interactions.&rft.au=Carlson%2C+John+H%3BWood%2C+Heidi%3BRoshick%2C+Christine%3BCaldwell%2C+Harlan+D%3BMcClarty%2C+Grant&rft.aulast=Carlson&rft.aufirst=John&rft.date=2006-03-01&rft.volume=59&rft.issue=6&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1989 Jun 5;264(16):9149-54 [2656696] J Mol Biol. 1988 Aug 20;202(4):769-77 [3050131] J Infect Dis. 1991 May;163(5):1103-7 [1673464] Microbiol Rev. 1991 Mar;55(1):143-90 [2030670] J Bacteriol. 1991 Jun;173(11):3601-4 [1904443] J Bacteriol. 1991 Aug;173(16):4932-40 [1860812] Eur J Biochem. 1991 Dec 5;202(2):459-70 [1761046] J Bacteriol. 1992 Jan;174(1):331-5 [1530846] Prog Nucleic Acid Res Mol Biol. 1992;42:1-38 [1574585] Biochemistry. 1992 Jun 30;31(25):5925-36 [1610835] J Mol Biol. 1994 May 13;238(4):592-614 [8176748] J Biol Chem. 1996 Jun 28;271(26):15393-400 [8663065] FEMS Microbiol Lett. 1997 Jun 15;151(2):225-30 [9228757] Science. 1998 Oct 23;282(5389):754-9 [9784136] Hautarzt. 1955 Nov;6(11):494-6 [13294661] Antimicrob Agents Chemother. 2005 Jan;49(1):406-7 [15616321] Antimicrob Agents Chemother. 2005 Mar;49(3):903-7 [15728882] Antimicrob Agents Chemother. 2005 Mar;49(3):1120-6 [15728912] Antimicrob Agents Chemother. 2005 Jul;49(7):2865-73 [15980362] Annu Rev Genet. 2005;39:47-68 [16285852] J Bacteriol. 2000 Jan;182(1):1-8 [10613855] Infect Immun. 2000 Mar;68(3):1337-49 [10678946] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12170-5 [11027315] J Biol Chem. 2000 Dec 1;275(48):38111-9 [10984489] J Exp Med. 2001 Apr 16;193(8):935-42 [11304554] Mol Microbiol. 2001 May;40(4):1027-36 [11401709] J Bacteriol. 2001 Sep;183(18):5414-25 [11514527] J Biol Chem. 2002 Jul 26;277(30):26893-903 [12011099] Genome Biol. 2002 Aug 29;3(9):research0051 [12225590] J Bacteriol. 2002 Dec;184(23):6566-71 [12426345] Biochemistry. 2002 Dec 17;41(50):14866-78 [12475235] J Clin Invest. 2003 Jun;111(11):1757-69 [12782678] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8478-83 [12815105] Mol Microbiol. 2003 Sep;49(5):1347-59 [12940992] Antimicrob Agents Chemother. 2004 Apr;48(4):1347-9 [15047540] Mol Microbiol. 2004 May;52(3):903-16 [15101993] Mol Gen Mikrobiol Virusol. 2004;(3):3-7 [15354934] Antimicrob Agents Chemother. 2004 Oct;48(10):3989-95 [15388463] Biochem Biophys Res Commun. 1970 Apr 8;39(1):13-9 [4910032] Biochemistry. 1975 Jul;14(13):3035-40 [1096937] J Mol Biol. 1975 Feb 15;92(1):93-111 [1097702] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2351-5 [1088825] Cell. 1980 Jun;20(2):269-81 [6248238] Proc Natl Acad Sci U S A. 1980 Dec;77(12):7117-21 [7012834] J Mol Biol. 1980 Dec 5;144(2):133-42 [7014917] J Mol Biol. 1981 Jan 5;145(1):47-73 [6167722] J Biol Chem. 1987 Apr 5;262(10):4922-7 [3549712] Nature. 1988 Sep 22;335(6188):321-9 [3419502] Biochim Biophys Acta. 1990 Apr 6;1048(2-3):113-26 [2182120] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Haplotype-based association analysis in cohort and nested case-control studies. AN - 67752104; 16542226 AB - Genetic epidemiologic studies often collect genotype data at multiple loci within a genomic region of interest from a sample of unrelated individuals. One popular method for analyzing such data is to assess whether haplotypes, i.e., the arrangements of alleles along individual chromosomes, are associated with the disease phenotype or not. For many study subjects, however, the exact haplotype configuration on the pair of homologous chromosomes cannot be derived with certainty from the available locus-specific genotype data (phase ambiguity). In this article, we consider estimating haplotype-specific association parameters in the Cox proportional hazards model, using genotype, environmental exposure, and the disease endpoint data collected from cohort or nested case-control studies. We study alternative Expectation-Maximization algorithms for estimating haplotype frequencies from cohort and nested case-control studies. Based on a hazard function of the disease derived from the observed genotype data, we then propose a semiparametric method for joint estimation of relative-risk parameters and the cumulative baseline hazard function. The method is greatly simplified under a rare disease assumption, for which an asymptotic variance estimator is also proposed. The performance of the proposed estimators is assessed via simulation studies. An application of the proposed method is presented, using data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. JF - Biometrics AU - Chen, Jinbo AU - Chatterjee, Nilanjan AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, Maryland 20852, USA. chenjin@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 28 EP - 35 VL - 62 IS - 1 SN - 0006-341X, 0006-341X KW - Index Medicus KW - Genotype KW - Epidemiologic Studies KW - Risk Factors KW - Humans KW - Neoplasms -- epidemiology KW - Environmental Exposure KW - Algorithms KW - Genetic Predisposition to Disease -- epidemiology KW - Neoplasms -- genetics KW - Haplotypes KW - Cohort Studies KW - Case-Control Studies KW - Proportional Hazards Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67752104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Haplotype-based+association+analysis+in+cohort+and+nested+case-control+studies.&rft.au=Chen%2C+Jinbo%3BChatterjee%2C+Nilanjan&rft.aulast=Chen&rft.aufirst=Jinbo&rft.date=2006-03-01&rft.volume=62&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176). AN - 67751091; 16533780 AB - The increased expression of markers associated with a differentiated phenotype, such as P-glycoprotein (Pgp), follows treatment with histone deacetylase inhibitors. Because depsipeptide (FR901228, FK228, NSC630176) is a substrate for Pgp, up-regulation of the gene that encodes it, MDR1, would mean that depsipeptide induces its own mechanism of resistance. To examine the effect of depsipeptide on expression of ATP-binding cassette transporters associated with multidrug resistance, the kidney cancer cell lines 108, 121, 127, and 143 were treated with depsipeptide and evaluated by quantitative reverse transcription-PCR. Increased levels of MDR1 (1.3- to 6.3-fold) and ABCG2 (3.2- to 11.1-fold) but not MRP1 (0.9- to 1.3-fold) were observed. The induced Pgp transported the fluorescent substrates rhodamine 123, bisantrene, calcein-AM, BODIPY-vinblastine, and BODIPY-paclitaxel. In normal peripheral blood mononuclear cells (PBMC) and circulating tumor cells obtained from patients receiving depsipeptide, increased levels of histone H3 acetylation were found. We next examined MDR1 levels in normal and malignant PBMCs obtained from 15 patients enrolled in clinical trials with depsipeptide and detected up to a 6-fold increase in normal PBMCs and up to an 8-fold increase in circulating tumor cells after depsipeptide administration. In one patient with Sézary syndrome, increased MDR1 gene expression was accompanied by increased cell surface Pgp expression in circulating Sézary cells as determined by measurement of MRK-16 staining by flow cytometry. These studies suggest that depsipeptide induces its own mechanism of resistance and thus provide a basis for clinical trials evaluating depsipeptide in combination with a Pgp inhibitor. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Robey, Robert W AU - Zhan, Zhirong AU - Piekarz, Richard L AU - Kayastha, Ganesh L AU - Fojo, Tito AU - Bates, Susan E AD - Cancer Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute, Bethesda, Maryland 20892, USA. robeyr@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1547 EP - 1555 VL - 12 IS - 5 SN - 1078-0432, 1078-0432 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Antibiotics, Antineoplastic KW - Antimetabolites KW - Antineoplastic Agents KW - Depsipeptides KW - Histones KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - RNA, Messenger KW - Hippocalcin KW - 149223-81-4 KW - Doxorubicin KW - 80168379AG KW - romidepsin KW - CX3T89XQBK KW - Didanosine KW - K3GDH6OH08 KW - Paclitaxel KW - P88XT4IS4D KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Kidney Neoplasms -- drug therapy KW - Humans KW - Hippocalcin -- pharmacology KW - Paclitaxel -- pharmacology KW - Carcinoma, Renal Cell -- drug therapy KW - Drug Resistance, Neoplasm KW - RNA, Messenger -- genetics KW - Drug Resistance, Multiple KW - Antimetabolites -- pharmacology KW - Tumor Cells, Cultured KW - Doxorubicin -- pharmacology KW - Sezary Syndrome -- metabolism KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Neoplasm Proteins -- genetics KW - Flow Cytometry KW - Neoplasm Proteins -- metabolism KW - Neoplastic Cells, Circulating -- metabolism KW - Kidney -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Kidney -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Sezary Syndrome -- drug therapy KW - Acetylation KW - Carcinoma, Renal Cell -- metabolism KW - RNA, Messenger -- metabolism KW - Histones -- metabolism KW - Colonic Neoplasms -- drug therapy KW - Kidney Neoplasms -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Colonic Neoplasms -- metabolism KW - Antineoplastic Agents -- pharmacology KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Leukocytes, Mononuclear -- metabolism KW - Depsipeptides -- pharmacology KW - Didanosine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67751091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Increased+MDR1+expression+in+normal+and+malignant+peripheral+blood+mononuclear+cells+obtained+from+patients+receiving+depsipeptide+%28FR901228%2C+FK228%2C+NSC630176%29.&rft.au=Robey%2C+Robert+W%3BZhan%2C+Zhirong%3BPiekarz%2C+Richard+L%3BKayastha%2C+Ganesh+L%3BFojo%2C+Tito%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-03-01&rft.volume=12&rft.issue=5&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial. AN - 67748781; 16537707 AB - Pro- and anti-inflammatory cytokine genes may be important in the maintenance and progression of colorectal cancer. It is possible that single-nucleotide polymorphisms in inflammatory genes may play a role in chronic colonic inflammation and development of colorectal adenomas. Furthermore, common variants in cytokine genes may modify the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer. We examined the association between cytokine gene polymorphisms and risk of recurrent adenomas among 1,723 participants in the Polyp Prevention Trial. We used logistic regression to calculate odds ratios (OR) for the association between genotype, NSAID use, and risk of adenoma recurrence. Cytokine gene polymorphisms were not statistically significantly associated with risk of adenoma recurrence in our study. We observed statistically significant interactions between NSAID use, IL-10 -1082 G>A genotype, and risk of adenoma recurrence (P = 0.01) and multiple adenoma recurrence (P = 0.01). Carriers of the IL-10 -1082 G>A variant allele who were non-NSAID users had a statistically significant decreased risk of multiple adenoma recurrence (OR, 0.43; 95% confidence interval, 0.24-0.77) as well as a nonsignificant 30% decreased risk of any adenoma recurrence. In contrast, NSAID users who were carriers of the IL-10 -1082 G>A variant allele were at an increased risk of any adenoma recurrence (OR, 1.55; 95% confidence interval, 1.00-2.43). These findings suggest that individuals who are carriers of the IL-10 -1082 G>A variant allele may not benefit from the chemoprotective effect of NSAIDs on adenoma polyp recurrence. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Sansbury, Leah B AU - Bergen, Andrew W AU - Wanke, Kay L AU - Yu, Binbing AU - Caporaso, Neil E AU - Chatterjee, Nilanjan AU - Ratnasinghe, Luke AU - Schatzkin, Arthur AU - Lehman, Teresa A AU - Kalidindi, Aravind AU - Modali, Ramakrishna AU - Lanza, Elaine AD - Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Suite 702, 6116 Executive Boulevard, MSC 8235, Bethesda, MD 20892-8325, USA. sansburl@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 494 EP - 501 VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Biomarkers, Tumor KW - Cytokines KW - Index Medicus KW - Sensitivity and Specificity KW - Genetic Variation KW - Odds Ratio KW - Neoplasm Staging KW - Humans KW - Aged KW - Biopsy, Needle KW - Risk Assessment KW - Polymerase Chain Reaction KW - Colonoscopy KW - Survival Rate KW - Logistic Models KW - Biomarkers, Tumor -- analysis KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Male KW - Colorectal Neoplasms -- mortality KW - Cytokines -- drug effects KW - Cytokines -- genetics KW - Neoplasm Recurrence, Local -- epidemiology KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Polymorphism, Genetic KW - Adenomatous Polyps -- therapy KW - Adenomatous Polyps -- pathology KW - Cytokines -- metabolism KW - Neoplasm Recurrence, Local -- prevention & control KW - Adenomatous Polyps -- mortality KW - Colorectal Neoplasms -- pathology KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Colorectal Neoplasms -- therapy KW - Neoplasm Recurrence, Local -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67748781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Inflammatory+cytokine+gene+polymorphisms%2C+nonsteroidal+anti-inflammatory+drug+use%2C+and+risk+of+adenoma+polyp+recurrence+in+the+polyp+prevention+trial.&rft.au=Sansbury%2C+Leah+B%3BBergen%2C+Andrew+W%3BWanke%2C+Kay+L%3BYu%2C+Binbing%3BCaporaso%2C+Neil+E%3BChatterjee%2C+Nilanjan%3BRatnasinghe%2C+Luke%3BSchatzkin%2C+Arthur%3BLehman%2C+Teresa+A%3BKalidindi%2C+Aravind%3BModali%2C+Ramakrishna%3BLanza%2C+Elaine&rft.aulast=Sansbury&rft.aufirst=Leah&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. AN - 67748657; 16537713 AB - Nucleotide excision repair (NER) is critical for protecting against damage from carcinogens in tobacco smoke. We evaluated the influence of common genetic variation in the NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6). Our study population included 1,150 patients with transitional cell carcinoma of the urinary bladder and 1,149 control subjects from Spain. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, and smoking status. Subjects with the variant genotypes for SNPs in four of the seven genes evaluated had small increases in bladder cancer risk compared to subjects with the homozygous wild-type genotypes: RAD23B IVS5-15A>G (OR, 1.3; 95% CI, 1.1-1.5; P = 0.01), ERCC2 R156R (OR, 1.3; 95% CI, 1.1-1.6; P = 0.006), ERCC1 IVS5+33A>C (OR, 1.2; 95% CI, 1.0-1.5; P = 0.06; P(trend) = 0.04), and ERCC5 M254V (OR, 1.4; 95% CI, 1.0-2.0; P = 0.04). A global test for pathway effects indicated that genetic variation in NER characterized by the 22 SNPs analyzed in this study significantly predicts bladder cancer risk (P = 0.04). Pairwise comparisons suggested that carrying variants in two genes could result in substantial increases in risk. Classification tree analyses suggested the presence of subgroups of individuals defined by smoking and NER genotypes that could have substantial increases in risk. In conclusion, these findings provide support for the influence of genetic variation in NER on bladder cancer risk. A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - García-Closas, Montserrat AU - Malats, Núria AU - Real, Francisco X AU - Welch, Robert AU - Kogevinas, Manolis AU - Chatterjee, Nilanjan AU - Pfeiffer, Ruth AU - Silverman, Debra AU - Dosemeci, Mustafa AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - Chanock, Stephen AU - Yeager, Meredith AU - Rothman, Nathaniel AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852-7234, USA. montse@nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 536 EP - 542 VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - DNA excision repair protein ERCC-5 KW - 0 KW - DNA-Binding Proteins KW - Genetic Markers KW - Nuclear Proteins KW - RAD23B protein, human KW - Transcription Factors KW - RAD23A protein, human KW - 156533-33-4 KW - ERCC1 protein, human KW - EC 3.1.- KW - Endonucleases KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Sensitivity and Specificity KW - Reference Values KW - Odds Ratio KW - Humans KW - Retrospective Studies KW - Prognosis KW - Aged KW - Risk Assessment KW - Age Distribution KW - Gene Expression Regulation, Neoplastic KW - Aged, 80 and over KW - Adult KW - Case-Control Studies KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Spain -- epidemiology KW - Sex Distribution KW - Male KW - Female KW - Survival Analysis KW - Urinary Bladder Neoplasms -- pathology KW - Nuclear Proteins -- genetics KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - DNA-Binding Proteins -- genetics KW - Genetic Variation -- genetics KW - Genetic Predisposition to Disease -- epidemiology KW - Endonucleases -- genetics KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67748657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Genetic+variation+in+the+nucleotide+excision+repair+pathway+and+bladder+cancer+risk.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BMalats%2C+N%C3%BAria%3BReal%2C+Francisco+X%3BWelch%2C+Robert%3BKogevinas%2C+Manolis%3BChatterjee%2C+Nilanjan%3BPfeiffer%2C+Ruth%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BRothman%2C+Nathaniel&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. AN - 67747168; 16533763 AB - The deleted in liver cancer-1 (DLC-1) gene that encodes a Rho GTPase-activating protein with tumor suppressor function is located on chromosome 8p21-22, a region frequently deleted in prostate carcinomas. This study was designed to determine whether DLC-1 is deregulated in prostate carcinomas and to assess the contribution of DLC-1 alterations to prostate carcinogenesis. Primary prostate carcinomas, prostate carcinoma cell lines, benign prostatic hyperplasias, and normal prostatic tissues were examined for detection of functional and structural alterations of the DLC-1 gene by real-time PCR, methylation-specific PCR, and Southern and Western blots. Down-regulation or loss of DCL-1 mRNA expression was detected in 10 of 27 (37%) prostate carcinomas, 3 of 5 (60%) prostate carcinoma cell lines, and 5 of 21 (24%) benign prostatic hyperplasias. DLC-1 promoter methylation was identified in 13 of 27 (48%) prostate carcinomas and 2 matching normal tissues and in 15 of 21 (71%) benign prostatic hyperplasias but was absent in 10 normal prostatic tissues from noncancerous individuals. Genomic deletions were found in only 3 prostate carcinomas and 1 benign prostatic hyperplasia. DLC-1 protein was not detected in 8 of 27 (30%) prostate carcinomas and 11 of 21 (52%) benign prostatic hyperplasias. Methylation of DLC-1 correlated with age in prostate carcinoma patients (P = 0.006) and with prostate-specific antigen blood levels in benign prostatic hyperplasia patients (P = 0.029). Treatment of the three prostate carcinoma cell lines (PC-3, LNCaP, and 22Rv1) expressing a low level of DLC-1 transcripts with inhibitors of DNA methyltransferase or histone deacetylase increased DLC-1 expression. These results show that the transcriptional silencing of DLC-1 by two epigenetic mechanisms is common and may be involved in the pathogenesis of prostate carcinomas and benign prostatic hyperplasias and could have potential clinical application in the early detection and gene therapy of prostate cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Guan, Ming AU - Zhou, Xiaoling AU - Soulitzis, Nikolaos AU - Spandidos, Demetrios A AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4262, USA. Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1412 EP - 1419 VL - 12 IS - 5 SN - 1078-0432, 1078-0432 KW - DLC1 protein, human KW - 0 KW - Enzyme Inhibitors KW - GTPase-Activating Proteins KW - RNA, Messenger KW - Tumor Suppressor Proteins KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Humans KW - Aged KW - RNA, Messenger -- genetics KW - Tumor Cells, Cultured KW - Down-Regulation KW - Blotting, Southern KW - Aged, 80 and over KW - Adult KW - Chromatin Immunoprecipitation KW - Molecular Sequence Data KW - Prostatic Hyperplasia -- metabolism KW - Promoter Regions, Genetic -- genetics KW - Prostatic Hyperplasia -- pathology KW - Male KW - Prostate -- metabolism KW - Acetylation KW - Blotting, Western KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Middle Aged KW - Prostatic Hyperplasia -- genetics KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - DNA Methylation KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Prostatic Neoplasms -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67747168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Aberrant+methylation+and+deacetylation+of+deleted+in+liver+cancer-1+gene+in+prostate+cancer%3A+potential+clinical+applications.&rft.au=Guan%2C+Ming%3BZhou%2C+Xiaoling%3BSoulitzis%2C+Nikolaos%3BSpandidos%2C+Demetrios+A%3BPopescu%2C+Nicholas+C&rft.aulast=Guan&rft.aufirst=Ming&rft.date=2006-03-01&rft.volume=12&rft.issue=5&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-03 N1 - Date created - 2006-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines. AN - 67738301; 16531823 AB - Efforts to develop effective cancer vaccines often use combinations of immunogenic peptides to increase the applicability and effectiveness of the immunizations. The immunologic consequences of combining more than 1 self/tumor antigen in a single vaccine emulsion remain unclear, however. We performed 2 sequential clinical trials in patients at high risk for melanoma recurrence. Patients were given the highly immunogenic gp100:209-217(210M) peptide and the less immunogenic tyrosinase:368-376(370D) peptide once every 3 weeks for 4 weeks. This vaccination course was 12 weeks long, and patients were vaccinated for up to 4 courses (16 total vaccinations). In the first trial in 31 patients, the peptides were emulsified separately in incomplete Freund adjuvant and injected at 2 different sites. In the second trial in 33 patients, the peptides were emulsified together and injected at the same site. Cryopreserved lymphocytes were obtained by apheresis after each course and were evaluated for antipeptide activity using tetramer, enzyme-linked immunospot, and in vitro sensitization boost assays. When the peptides were injected at separate sites, robust specific reactivity to the native gp100:209-217 peptide was measured by each of the assays, whereas immunization with the tyrosinase:368-376(370D) peptide was far less effective. When the peptides were emulsified and injected together at the same site, immunization to the gp100:209-217(210M) epitope dropped precipitously, whereas reactivity to the tyrosinase:368-376(370D) peptide was enhanced. These cautionary data indicate that mixing peptides in the same emulsion can alter reactivity compared with peptides injected separately by mechanisms that may include the induction of localized nonspecific inflammation or competitive binding of peptides to major histocompatibility complex molecules. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Rosenberg, Steven A AU - Sherry, Richard M AU - Morton, Kathleen E AU - Yang, James C AU - Topalian, Suzanne L AU - Royal, Richard E AU - Kammula, Udai S AU - Restifo, Nicholas P AU - Hughes, Marybeth S AU - Schwarz, Susan L AU - Ngo, Lien T AU - Mavroukakis, Sharon A AU - White, Donald E AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. SAR@nih.gov PY - 2006 SP - 224 EP - 231 VL - 29 IS - 2 SN - 1524-9557, 1524-9557 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Membrane Glycoproteins KW - PMEL protein, human KW - gp100 Melanoma Antigen KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Index Medicus KW - Monophenol Monooxygenase -- immunology KW - Monophenol Monooxygenase -- administration & dosage KW - Humans KW - Aged KW - Monophenol Monooxygenase -- chemistry KW - Antigens, Neoplasm -- administration & dosage KW - Drug Interactions -- immunology KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Antigens, Neoplasm -- immunology KW - Secondary Prevention KW - Female KW - Male KW - Cancer Vaccines -- administration & dosage KW - Cancer Vaccines -- immunology KW - Melanoma -- pathology KW - Melanoma -- therapy KW - Melanoma -- immunology KW - Membrane Glycoproteins -- immunology KW - Membrane Glycoproteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67738301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Altered+CD8%28%2B%29+T-cell+responses+when+immunizing+with+multiepitope+peptide+vaccines.&rft.au=Rosenberg%2C+Steven+A%3BSherry%2C+Richard+M%3BMorton%2C+Kathleen+E%3BYang%2C+James+C%3BTopalian%2C+Suzanne+L%3BRoyal%2C+Richard+E%3BKammula%2C+Udai+S%3BRestifo%2C+Nicholas+P%3BHughes%2C+Marybeth+S%3BSchwarz%2C+Susan+L%3BNgo%2C+Lien+T%3BMavroukakis%2C+Sharon+A%3BWhite%2C+Donald+E&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2006-03-01&rft.volume=29&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2001 Oct;7(10):3012-24 [11595689] J Immunother. 2001 Jul-Aug;24(4):363-73 [11565838] J Clin Oncol. 2003 Apr 15;21(8):1562-73 [12697882] J Clin Oncol. 2003 Jun 15;21(12):2415-32 [12805342] Cancer Immun. 2003 Oct 28;3:15 [14580186] J Clin Oncol. 2003 Nov 1;21(21):4016-26 [14581425] Cancer Invest. 2003;21(6):873-86 [14735692] J Immunol. 2004 Apr 1;172(7):4575-82 [15034075] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 1996 Feb 1;183(2):527-34 [8627164] J Immunol. 1996 Sep 15;157(6):2539-48 [8805655] J Immunol. 1998 Feb 15;160(4):1750-8 [9469433] Nat Med. 1998 Mar;4(3):321-7 [9500606] Annu Rev Immunol. 1999;17:51-88 [10358753] J Immunother. 2004 Nov-Dec;27(6):425-31 [15534486] J Immunol. 2005 Nov 1;175(9):6169-76 [16237114] Clin Cancer Res. 1999 Oct;5(10):2756-65 [10537339] Cancer Res. 1999 Dec 15;59(24):6230-8 [10626817] J Immunother. 2000 Mar-Apr;23(2):275-81 [10746554] Nature. 2001 May 17;411(6835):380-4 [11357146] Clin Cancer Res. 2002 May;8(5):967-72 [12006508] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. AN - 67737351; 16530703 AB - MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer. JF - Cancer cell AU - Yanaihara, Nozomu AU - Caplen, Natasha AU - Bowman, Elise AU - Seike, Masahiro AU - Kumamoto, Kensuke AU - Yi, Ming AU - Stephens, Robert M AU - Okamoto, Aikou AU - Yokota, Jun AU - Tanaka, Tadao AU - Calin, George Adrian AU - Liu, Chang-Gong AU - Croce, Carlo M AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 189 EP - 198 VL - 9 IS - 3 SN - 1535-6108, 1535-6108 KW - Biomarkers, Tumor KW - 0 KW - MicroRNAs KW - Index Medicus KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Aged KW - Middle Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Female KW - Survival Analysis KW - Biomarkers, Tumor -- genetics KW - Adenocarcinoma -- mortality KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- mortality KW - Adenocarcinoma -- genetics KW - MicroRNAs -- analysis KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67737351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+cell&rft.atitle=Unique+microRNA+molecular+profiles+in+lung+cancer+diagnosis+and+prognosis.&rft.au=Yanaihara%2C+Nozomu%3BCaplen%2C+Natasha%3BBowman%2C+Elise%3BSeike%2C+Masahiro%3BKumamoto%2C+Kensuke%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BOkamoto%2C+Aikou%3BYokota%2C+Jun%3BTanaka%2C+Tadao%3BCalin%2C+George+Adrian%3BLiu%2C+Chang-Gong%3BCroce%2C+Carlo+M%3BHarris%2C+Curtis+C&rft.aulast=Yanaihara&rft.aufirst=Nozomu&rft.date=2006-03-01&rft.volume=9&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Cancer+cell&rft.issn=15356108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Chem. 2013 Dec;59(12):1811-2 [23462030] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. AN - 67736831; 16531821 AB - CD4(+)CD25(+) T-regulatory cells (T(reg)) can inhibit the proliferation and cytokine secretion of CD4(+)CD25(-) helper T cells in mice and humans. In murine tumor models, the presence of these T(reg) cells can inhibit the antitumor effectiveness of T-cell transfer and active immunization approaches. We have thus initiated efforts to eliminate T(reg) cells selectively from human peripheral blood mononuclear cells (PBMCs) to potentially bolster antitumor responses. LMB-2 is a recombinant immunotoxin that is a fusion of a single-chain Fv fragment of the anti-Tac anti-CD25 monoclonal antibody to a truncated form of the bacterial Pseudomonas exotoxin A. In vitro incubation of human PBMCs with LMB-2 reduced the levels of CD4(+)CD25(+) and Foxp3-expressing cells without impairing the function of the remaining lymphocytes. The short in vivo half-life of LMB-2 makes it an attractive candidate for reducing human T(reg) cells in vivo before the administration of cancer vaccine or cell transfer immunotherapy approaches. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Attia, Peter AU - Powell, Daniel J AU - Maker, Ajay V AU - Kreitman, Robert J AU - Pastan, Ira AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. PY - 2006 SP - 208 EP - 214 VL - 29 IS - 2 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD4 KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Cancer Vaccines KW - Exotoxins KW - Immunotoxins KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Exotoxins -- administration & dosage KW - Humans KW - Immunotherapy KW - Mice KW - Exotoxins -- immunology KW - Antigens, CD4 -- immunology KW - Cell Death -- immunology KW - Receptors, Interleukin-2 -- immunology KW - Cells, Cultured KW - Recombinant Proteins -- immunology KW - Lymphocyte Depletion -- methods KW - Recombinant Proteins -- administration & dosage KW - Immunotoxins -- immunology KW - Immunotoxins -- administration & dosage KW - T-Lymphocytes, Regulatory -- pathology KW - Antibodies, Monoclonal -- administration & dosage KW - T-Lymphocytes, Regulatory -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67736831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Selective+elimination+of+human+regulatory+T+lymphocytes+in+vitro+with+the+recombinant+immunotoxin+LMB-2.&rft.au=Attia%2C+Peter%3BPowell%2C+Daniel+J%3BMaker%2C+Ajay+V%3BKreitman%2C+Robert+J%3BPastan%2C+Ira%3BRosenberg%2C+Steven+A&rft.aulast=Attia&rft.aufirst=Peter&rft.date=2006-03-01&rft.volume=29&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1999 Nov 15;94(10):3340-8 [10552943] J Immunother. 2005 Nov-Dec;28(6):582-92 [16224276] Nat Genet. 2001 Jan;27(1):20-1 [11137993] Cancer Res. 2002 Jul 15;62(14):3914-9 [12124318] Science. 2002 Oct 25;298(5594):850-4 [12242449] J Immunother. 2003 Jan-Feb;26(1):85-93 [12514432] Curr Opin Mol Ther. 2003 Feb;5(1):44-51 [12669470] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] J Leukoc Biol. 2003 Dec;74(6):961-5 [12960253] Immunity. 2004 Jan;20(1):107-18 [14738769] Novartis Found Symp. 2004;256:149-52; discussion 152-7, 259-69 [15027488] Annu Rev Immunol. 2004;22:531-62 [15032588] J Immunol. 2004 Jul 15;173(2):1444-53 [15240741] Expert Opin Biol Ther. 2004 Jul;4(7):1115-28 [15268678] Nat Med. 2004 Sep;10(9):942-9 [15322536] Blood. 1988 Nov;72(5):1805-16 [2846094] Nature. 1989 Jun 1;339(6223):394-7 [2498664] Proc Natl Acad Sci U S A. 1989 Dec;86(23):9485-8 [2594781] Transplantation. 1990 Jan;49(1):198-201 [2301012] Eur J Immunol. 1990 Apr;20(4):785-91 [2140788] Blood. 1993 Sep 15;82(6):1701-12 [8400227] Blood. 1994 Jan 15;83(2):426-34 [8286741] Bioconjug Chem. 1993 Nov-Dec;4(6):581-5 [8305530] Bioconjug Chem. 1993 Mar-Apr;4(2):112-20 [7873642] Transplant Proc. 1998 Aug;30(5):2155-8 [9723424] Immunity. 1999 Mar;10(3):281-7 [10204484] J Immunol. 1999 Aug 1;163(3):1690-5 [10415076] J Immunother. 2005 Mar-Apr;28(2):120-8 [15725955] J Immunol. 2005 Mar 1;174(5):2591-601 [15728465] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] J Immunother. 2005 Jul-Aug;28(4):403-11 [16000960] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment and management of chronic hepatitis B. AN - 67735212; 16527649 AB - An understanding of the natural history of CHB is critical for the management of the liver disease. Three clinical patterns with different clinical outcomes are recognized: HBeAg-positive CHB, HBeAg-negative CHB,and inactive CHB. Patients with elevated aminotransferase levels and HBV DNA greater than 105 viral copies per mL in serum and with features of chronic hepatitis on liver biopsy are candidates for therapy regardless of HBeAg status. Multiple host and viral factors and safety profiles of current therapies need to be considered carefully before recommending therapy. There appears to be no role for HBV genotyping in the management of patients. Three antiviral agents are approved for use against CHB infection:IFN-a, lamivudine, and adefovir. Efficacy is moderate at best and is limited by the poor tolerability of IFN and the development of resistance, coupled with concerns regarding the long-term safety with nucleoside analogs. Several new nucleoside and nucleotide analogs and novel agents are at various stages of development as potential therapies for CHB. The ideal compound would be one that is active against all replicative intermediates of the virus and has a low toxicity profile. Despite current shortcomings, the future of therapy for HBV is promising, as newer therapeutic options are being developed based on an understanding of the HBV life cycle. JF - Infectious disease clinics of North America AU - Ghany, Marc G AU - Doo, Edward C AD - Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-06, 10 Center Drive, MSC 1800, Bethesda, MD 29892-1800, USA. marcg@bldg10.niddk.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 63 EP - 79 VL - 20 IS - 1 SN - 0891-5520, 0891-5520 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67735212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disease+clinics+of+North+America&rft.atitle=Assessment+and+management+of+chronic+hepatitis+B.&rft.au=Ghany%2C+Marc+G%3BDoo%2C+Edward+C&rft.aulast=Ghany&rft.aufirst=Marc&rft.date=2006-03-01&rft.volume=20&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Infectious+disease+clinics+of+North+America&rft.issn=08915520&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2006-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint Of: Gastroenterol Clin North Am. 2004 Sep;33(3):563-79, ix [15324944] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors. AN - 67729245; 16522397 AB - Vasoactive intestinal peptide (VIP)-related peptides prevented the learning deficit in the offspring in a model for fetal alcohol syndrome. We evaluated whether the mechanism of the peptide protection included NR2B, NR2A, and GABAAalpha5. Timed, pregnant C57BL6/J mice were injected on gestational day 8 with alcohol (0.03 mL/kg), placebo, or alcohol plus peptides. Embryos were harvested after 6 hours, 24 hours, and on gestational day 18. Some of the litters were allowed to deliver, and the adult brains harvested after the offspring were tested for learning. Calibrator-normalized relative real-time polymerase chain reaction (PCR) was performed using primers for NR2B, NR2A, and GABAAalpha5 with GAPDH standardization. Statistic: analysis of variance (ANOVA) and Fisher PLSD, P < .05 was considered significant. In the embryo, the peptides prevented NR2B rise (P < .001) at 6 hours, NR2B down-regulation (P = .002), and GABAAalpha5 decrease (P < .01) on gestational day 18. In the adult, the peptides prevented NR2B down-regulation (P = .01) and NR2A up-regulation (P < .001). VIP-related peptides prevented alcohol-induced changes in NR2B, NR2A, and GABAAalpha5. This may explain, at least in part, the peptides' prevention of alcohol-induced learning deficits. JF - American journal of obstetrics and gynecology AU - Toso, Laura AU - Poggi, Sarah H AU - Roberson, Robin AU - Woodard, Jade AU - Park, Jane AU - Abebe, Daniel AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD 20892-0925, USA. laura_toso@hotmail.com Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 681 EP - 686 VL - 194 IS - 3 KW - Gabra5 protein, mouse KW - 0 KW - NR2A NMDA receptor KW - NR2B NMDA receptor KW - Oligopeptides KW - Protein Subunits KW - Receptors, GABA-A KW - Receptors, N-Methyl-D-Aspartate KW - activity-dependent neurotrophic factor KW - davunetide KW - GF00K3IIWE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Pregnancy KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, GABA-A -- physiology KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Oligopeptides -- therapeutic use KW - Receptors, GABA-A -- drug effects KW - Fetal Alcohol Spectrum Disorders KW - Learning Disorders -- etiology KW - Learning Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Prevention+of+alcohol-induced+learning+deficits+in+fetal+alcohol+syndrome+mediated+through+NMDA+and+GABA+receptors.&rft.au=Toso%2C+Laura%3BPoggi%2C+Sarah+H%3BRoberson%2C+Robin%3BWoodard%2C+Jade%3BPark%2C+Jane%3BAbebe%2C+Daniel%3BSpong%2C+Catherine+Y&rft.aulast=Toso&rft.aufirst=Laura&rft.date=2006-03-01&rft.volume=194&rft.issue=3&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemotherapy-induced neutropenia: a useful predictor of treatment efficacy? AN - 67726663; 16520781 JF - Nature clinical practice. Oncology AU - Di Maio, Massimo AU - Gridelli, Cesare AU - Gallo, Ciro AU - Perrone, Francesco AD - Clinical Trials Unit of the National Cancer Institute of Naples, Italy. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 114 EP - 115 VL - 3 IS - 3 SN - 1743-4254, 1743-4254 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Survival Analysis KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Neutropenia -- chemically induced KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67726663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Oncology&rft.atitle=Chemotherapy-induced+neutropenia%3A+a+useful+predictor+of+treatment+efficacy%3F&rft.au=Di+Maio%2C+Massimo%3BGridelli%2C+Cesare%3BGallo%2C+Ciro%3BPerrone%2C+Francesco&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2006-03-01&rft.volume=3&rft.issue=3&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Oncology&rft.issn=17434254&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-27 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weekly paclitaxel, 5-fluorouracil and folinic acid with granulocyte colony-stimulating factor support in metastatic breast cancer patients: a phase II study. AN - 67720903; 16520664 AB - We conducted a phase II study to determine the activity and tolerability of weekly paclitaxel, 5-fluorouracil (5-FU) and folinic acid plus granulocyte colony-stimulating factor (G-CSF) support in anthracycline-pre-treated or -resistant metastatic breast cancer patients. The phase II study was designed following the Simon optimal-two stage method. Patients received paclitaxel 80 mg/m, folinic acid 10 mg/m and bolus infusion of 5-FU 300 mg/m every week plus G-CSF on day 3 for 24 consecutive weeks in the absence of disease progression. From May 1998 to May 2000, 51 patients entered the study. Patients received a median relative dose intensity of 97.5% (range 81-100%). No severe toxicities were observed. Seven patients (14%) experienced neutropenia grade 2. Seven patients (14%) experienced grade 2 anemia. Two patients (4%) experienced severe asthenia. Three out of 50 evaluable patients [6%, 95% confidence interval (CI) 2-12.6%] showed a complete response, whereas 23 (46%, 95% CI 32.2-59.8%) had a partial response, with an overall response rate of 52% (95% CI 38.2-65.8%). In addition, eight patients (15.7%) had stable disease. In the 13 patients untreated for metastatic disease, the overall response rate was 92.3% (CI 77.8-100), with one complete response and 11 partial responses (84.6% CI 65-100%). In the whole group, the median time to progression and overall survival were 8 (range 1-18) and 14 months (95% CI 11-17), respectively. Thus, in metastatic breast cancer patients pre-treated with anthracyclines, the weekly administration of paclitaxel, 5-FU and folinic acid with G-CSF support seems to be extremely tolerable and active. JF - Anti-cancer drugs AU - Nistico, Cecilia AU - Bria, Emilio AU - Agostara, Biagio AU - Barni, Sandro AU - Colella, Elvira AU - Frontini, Luciano AU - D'Ottavio, Anna Maria AU - Cuppone, Federica AU - Valenza, Roberto AU - Sperduti, Isabella AU - Izzo, Fiorentino AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Roma, Italy. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 345 EP - 351 VL - 17 IS - 3 SN - 0959-4973, 0959-4973 KW - Anthracyclines KW - 0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Paclitaxel KW - P88XT4IS4D KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Drug Administration Schedule KW - Anthracyclines -- pharmacology KW - Humans KW - Leucovorin -- administration & dosage KW - Aged KW - Leucovorin -- adverse effects KW - Drug Resistance, Neoplasm KW - Fluorouracil -- administration & dosage KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Fluorouracil -- adverse effects KW - Paclitaxel -- adverse effects KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67720903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Weekly+paclitaxel%2C+5-fluorouracil+and+folinic+acid+with+granulocyte+colony-stimulating+factor+support+in+metastatic+breast+cancer+patients%3A+a+phase+II+study.&rft.au=Nistico%2C+Cecilia%3BBria%2C+Emilio%3BAgostara%2C+Biagio%3BBarni%2C+Sandro%3BColella%2C+Elvira%3BFrontini%2C+Luciano%3BD%27Ottavio%2C+Anna+Maria%3BCuppone%2C+Federica%3BValenza%2C+Roberto%3BSperduti%2C+Isabella%3BIzzo%2C+Fiorentino%3BTerzoli%2C+Edmondo&rft.aulast=Nistico&rft.aufirst=Cecilia&rft.date=2006-03-01&rft.volume=17&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers. AN - 67714355; 16325293 AB - Alcoholism and heavy drinking are associated with a number of physiological, behavioral, affective, and cognitive problems. One such problem involves dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, with alcoholics showing higher basal cortisol levels and reduced inhibitory feedback control. In addition, alcohol consumption is associated with decreased heart rate variability (HRV). In the present study we examined the relationships among alcohol consumption, cortisol excretion, and HRV in 542 apparently healthy men. Men in the top tertile of self-reported alcohol consumption had higher cortisol levels and lower HRV compared to men in the lower two tertiles of alcohol consumption. In addition, the inverse relationship between cortisol and HRV was greatly attenuated in the heavy drinking group even after accounting for a number of potential confounding factors. These results support prior research on the HPA axis dysregulation in alcoholics and suggest impaired inhibitory control of the HPA axis in heavy drinkers. The findings are consistent with the neurovisceral integration model, which links central and peripheral processes, and may provide a comprehensive framework for the future investigation of the complex mix of physiological, behavioral, affective, and cognitive factors which comprise the heavy drinking phenotype. JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology AU - Thayer, Julian F AU - Hall, Martica AU - Sollers, John J AU - Fischer, Joachim E AD - National Institute on Aging, NIA/GRC/LPC, 5600 Nathan Shock Drive, Baltimore, MD 21224, United States. thayerj@grc.nia.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 244 EP - 250 VL - 59 IS - 3 SN - 0167-8760, 0167-8760 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Reference Values KW - Electrocardiography, Ambulatory KW - Humans KW - Prefrontal Cortex -- physiopathology KW - Neural Inhibition -- physiology KW - Heart -- innervation KW - Amygdala -- physiopathology KW - Feedback -- physiology KW - Electrocardiography KW - Adult KW - Middle Aged KW - Parasympathetic Nervous System -- physiopathology KW - Adolescent KW - Male KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Pituitary-Adrenal System -- physiopathology KW - Heart Rate -- physiology KW - Alcohol Drinking -- physiopathology KW - Alcohol Drinking -- adverse effects KW - Hydrocortisone -- urine KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67714355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+psychophysiology+%3A+official+journal+of+the+International+Organization+of+Psychophysiology&rft.atitle=Alcohol+use%2C+urinary+cortisol%2C+and+heart+rate+variability+in+apparently+healthy+men%3A+Evidence+for+impaired+inhibitory+control+of+the+HPA+axis+in+heavy+drinkers.&rft.au=Thayer%2C+Julian+F%3BHall%2C+Martica%3BSollers%2C+John+J%3BFischer%2C+Joachim+E&rft.aulast=Thayer&rft.aufirst=Julian&rft.date=2006-03-01&rft.volume=59&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=International+journal+of+psychophysiology+%3A+official+journal+of+the+International+Organization+of+Psychophysiology&rft.issn=01678760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-01 N1 - Date created - 2006-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure. AN - 67704885; 16507464 AB - Our previous work has shown that exposure to inorganic arsenic in utero produces hepatocellular carcinoma (HCC) in adult male mice. To explore further the molecular mechanisms of transplacental arsenic hepatocarcinogenesis, we conducted a second arsenic transplacental carcinogenesis study and used a genomewide microarray to profile arsenic-induced aberrant gene expression more extensively. Briefly, pregnant C3H mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from days 8 to 18 of gestation. The incidence of HCC in adult male offspring was increased 4-fold and tumor multiplicity 3-fold after transplacental arsenic exposure. Samples of normal liver and liver tumors were taken at autopsy for genomic analysis. Arsenic exposure in utero resulted in significant alterations (p 90% concordance. Arsenic-altered gene expression included activation of oncogenes and HCC biomarkers, and increased expression of cell proliferation-related genes, stress proteins, and insulin-like growth factors and genes involved in cell-cell communications. Liver feminization was evidenced by increased expression of estrogen-linked genes and altered expression of genes that encode gender-related metabolic enzymes. These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis. JF - Environmental health perspectives AU - Liu, Jie AU - Xie, Yaxiong AU - Ducharme, Danica M K AU - Shen, Jun AU - Diwan, Bhalchandra A AU - Merrick, B Alex AU - Grissom, Sherry F AU - Tucker, Charles J AU - Paules, Richard S AU - Tennant, Raymond AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 404 EP - 411 VL - 114 IS - 3 SN - 0091-6765, 0091-6765 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Maternal-Fetal Exchange KW - Gene Expression Profiling KW - Animals KW - Mice, Inbred C3H KW - Toxicogenetics KW - Mice KW - Male KW - Female KW - Pregnancy KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Arsenic -- toxicity KW - Liver -- drug effects KW - Liver -- metabolism KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67704885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+gene+expression+associated+with+hepatocarcinogenesis+in+adult+male+mice+induced+by+in+utero+arsenic+exposure.&rft.au=Liu%2C+Jie%3BXie%2C+Yaxiong%3BDucharme%2C+Danica+M+K%3BShen%2C+Jun%3BDiwan%2C+Bhalchandra+A%3BMerrick%2C+B+Alex%3BGrissom%2C+Sherry+F%3BTucker%2C+Charles+J%3BPaules%2C+Richard+S%3BTennant%2C+Raymond%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-03-01&rft.volume=114&rft.issue=3&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Carcinog. 2001 Feb;30(2):79-87 [11241755] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Anticancer Res. 2001 Mar-Apr;21(2B):1339-45 [11396210] Toxicol Appl Pharmacol. 2000 Apr 15;164(2):161-70 [10764629] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] Cancer Res. 2000 Jul 1;60(13):3445-53 [10910055] Environ Health Perspect. 2000 Jul;108(7):655-61 [10903620] J Toxicol Clin Toxicol. 2000;38(4):395-405 [10930056] Toxicol Sci. 2001 Jan;59(1):185-92 [11134558] Cancer Res. 2001 Jul 15;61(14):5389-95 [11454681] Mol Pharmacol. 2001 Aug;60(2):302-9 [11455017] Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8 [11559025] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Environ Health Perspect. 2002 Feb;110(2):119-22 [11836136] Toxicol Lett. 2002 Mar 10;128(1-3):73-84 [11869819] Carcinogenesis. 2002 May;23(5):777-85 [12016150] Int J Cancer. 2002 Jun 10;99(5):629-34 [12115494] Carcinogenesis. 2002 Aug;23(8):1387-97 [12151359] Alcohol. 2002 Jul;27(3):155-62 [12163143] Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 [12426152] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Carcinogenesis. 2003 Apr;24(4):757-70 [12727805] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Horm Metab Res. 2003 Nov-Dec;35(11-12):685-93 [14710347] Toxicol Pathol. 2004 Jan-Feb;32(1):64-72 [14713550] Toxicol Sci. 2004 Feb;77(2):249-57 [14691202] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Am J Public Health. 2004 May;94(5):741-4 [15117692] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Lab Invest. 2004 Sep;84(9):1137-47 [15220935] Environ Health Perspect. 2004 Aug;112(12):1255-63 [15345372] J Toxicol Environ Health A. 2004 Oct 8;67(19):1491-500 [15371225] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] J Hyg Epidemiol Microbiol Immunol. 1988;32(2):137-46 [2457611] J Pharmacol Exp Ther. 1996 May;277(2):1026-33 [8627513] J Gastroenterol Hepatol. 1997 Oct;12(9-10):S294-308 [9407350] Mol Cell Biol. 1998 Aug;18(8):4499-508 [9671459] Toxicol Sci. 1998 Aug;44(2):185-90 [9742656] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] World J Gastroenterol. 2004 Dec 1;10(23):3414-8 [15526358] Int J Oncol. 2005 Feb;26(2):369-77 [15645121] FEBS J. 2005 Jan;272(2):413-21 [15654879] Oncogene. 2005 Mar 10;24(11):1831-46 [15674350] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8644-9 [15937110] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice. AN - 67703469; 16180012 AB - Fifteen-day and 14-week studies of 2-methylimidazole (2MI) and 4-methylimidazole (4MI) were conducted because of widespread human exposure via ingestion of food products containing the compounds and lack of toxicity data. Groups of five male and five female Fischer rats and B6C3F1 mice were administered 2MI by dosed feed at 0, 1,200, 3,300, or 10,000 ppm or 4MI at 0, 300, 800, or 2,500 ppm for 15 days, and groups of 10 male and 10 female Fischer rats and B6C3F1 mice were administered 2MI or 4MI at 0, 625, 1,250, 2,500, 5,000 or 10,000 ppm for 14 weeks. In the 15-day studies, 2MI induced thyroid follicular-cell hyperplasia and pituitary pars-distalis hypertrophy in rats and thyroid follicular-cell hypertrophy and spleen hematopoietic-cell proliferation in mice; 4MI induced no histopathological changes in rats and mice. In the 14-week studies, 2MI increased concentrations of thyroid-stimulating hormone (TSH) and decreased those of thyroxine (T(4)) and triiodothyroxine (T(3)) in male and female rats according to the dosage. Incidences of diffuse follicular-cell hyperplasia of the thyroid gland increased significantly in male rats exposed to 1,250 ppm or greater and female rats exposed to 2,500 ppm or greater. Thyroid follicular-cell adenoma was diagnosed in two males in the 10,000-ppm group. A dose-related anemia occurred in female rats. In mice, follicular-cell hypertrophy of the thyroid gland, anemia, splenic hematopoietic-cell proliferation, and hemosiderin in kidney tubules appeared. In rats, 4MI induced tremors and ataxia in the high-dose groups. Serum T(3), T(4), and TSH levels were not altered, and no thyroid lesions occurred. Anemia, hepatocytic vacuolation, testicular degeneration, and prostatic atrophy were observed. In mice, anemia, liver cytoplasmic vacuolization, and renal degeneration and dilation occurred. Our studies demonstrated that, in rats and mice, 2MI induces thyroid hyperplasia and hypertrophy, and both 2MI and 4MI induce anemia; 2MI induces thyroid follicular-cell adenoma in male rats. JF - Archives of toxicology AU - Chan, Po AU - Mahler, Joel AU - Travlos, Greg AU - Nyska, Abraham AU - Wenk, M AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. chanp@niehs.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 169 EP - 180 VL - 80 IS - 3 SN - 0340-5761, 0340-5761 KW - Imidazoles KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyroxine KW - Q51BO43MG4 KW - 4-methylimidazole KW - Q64GF9FV4I KW - 2-methylimidazole KW - T0049Z45LZ KW - Index Medicus KW - Neoplasms, Experimental -- epidemiology KW - Molecular Structure KW - Animals KW - Hyperplasia -- pathology KW - Sex Factors KW - Triiodothyronine -- blood KW - Dose-Response Relationship, Drug KW - Toxicity Tests, Acute -- methods KW - Mice KW - Thyroxine -- blood KW - Neoplasms, Experimental -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Hyperplasia -- chemically induced KW - Hypertrophy -- pathology KW - Neoplasms, Experimental -- chemically induced KW - Incidence KW - Hypertrophy -- chemically induced KW - Female KW - Male KW - Toxicity Tests, Chronic -- methods KW - Thyroid Diseases -- pathology KW - Imidazoles -- toxicity KW - Imidazoles -- administration & dosage KW - Thyroid Diseases -- chemically induced KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67703469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Induction+of+thyroid+lesions+in+14-week+toxicity+studies+of+2+and+4-methylimidazole+in+Fischer+344%2FN+rats+and+B6C3F1+mice.&rft.au=Chan%2C+Po%3BMahler%2C+Joel%3BTravlos%2C+Greg%3BNyska%2C+Abraham%3BWenk%2C+M&rft.aulast=Chan&rft.aufirst=Po&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. AN - 67698974; 16314872 AB - The neuropeptide galanin (GAL) is widely expressed in the central nervous system. Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. The coding sequence of the galanin gene, GAL, is highly conserved and a functional polymorphism has not yet been found. The aim of our study was, for the first time, to identify GAL haplotypes and investigate associations with alcoholism and anxiety. Seven single-nucleotide polymorphisms (SNPs) spanning GAL were genotyped in 65 controls from five populations: US and Finnish Caucasians, African Americans, Plains and Southwestern Indians. A single haplotype block with little evidence of historical recombination was observed for each population. Four tag SNPs were then genotyped in DSM-III-R lifetime alcoholics and nonalcoholics from two population isolates: 514 Finnish Caucasian men and 331 Plains Indian men and women. Tridimensional Personality Questionnaire harm avoidance (HA) scores, a dimensional measure of anxiety, were obtained. There was a haplotype association with alcoholism in both the Finnish (P=0.001) and Plains Indian (P=0.004) men. The SNPs were also significantly associated. Alcoholics were divided into high and low HA groups (>or= and or =10 cigarettes/d), only 12% of alcoholic men and 8% of alcoholic women smoked heavily (>20/d). In women, the COMT Val158 allele frequency was maximal in alcoholic smokers (0.85), decreasing to 0.74 in nonalcoholic smokers, 0.67 in alcoholic nonsmokers, and 0.64 in nonalcoholic nonsmokers (chi2 = 11.1, 3 df, p = 0.011). Women showed a main effect of Val158 on smoking (p=0.003). Both male and female alcoholics were more likely to have at least 1 Val158 allele compared with nonalcoholics (0.95 vs 0.88, p < 0.05). Approximately 30% of all participants were long-term, nonaddicted light, social smokers (3.6+/-1.7 cigarettes/d); they had the same Val158Met frequencies as nonsmokers. Haplotype analyses supported the Val158Met findings; however, only 1 of the 2 Val158 haplotypes was implicated. Plains Indians have different smoking and drinking patterns and considerably less comorbidity between alcoholism and heavy smoking compared with the general U.S. population. Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women. JF - Alcoholism, clinical and experimental research AU - Enoch, Mary-Anne AU - Waheed, Juwaria F AU - Harris, Claudia R AU - Albaugh, Bernard AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892-9412, USA. maennoch@niaaa.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 399 EP - 406 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Phosphodiesterase I KW - EC 3.1.4.1 KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Psychiatric Status Rating Scales KW - Haplotypes KW - Sex Characteristics KW - Polymorphism, Genetic KW - Humans KW - Adult KW - Phosphodiesterase I -- genetics KW - Indians, North American -- statistics & numerical data KW - Male KW - Female KW - Catechol O-Methyltransferase -- genetics KW - Alcoholism -- epidemiology KW - Smoking -- genetics KW - Alcoholism -- genetics KW - Alcoholism -- complications KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67690740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Sex+differences+in+the+influence+of+COMT+Val158Met+on+alcoholism+and+smoking+in+plains+American+Indians.&rft.au=Enoch%2C+Mary-Anne%3BWaheed%2C+Juwaria+F%3BHarris%2C+Claudia+R%3BAlbaugh%2C+Bernard%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion: analysis of morbidity and mortality in 209 peritoneal surface malignancies treated with closed abdomen technique. AN - 67688149; 16456817 AB - The purpose of this prospective Phase II study was to analyze morbidity and mortality of cytoreductive surgery (CRS) and intraperitoneal hyperthermic perfusion (IPHP) in the treatment of peritoneal surface malignancies. A total of 205 patients (50 with peritoneal mesothelioma, 49 with pseudomyxoma peritonei, 41 with ovarian cancer, 32 with abdominal sarcomatosis, 13 with colon cancer, 12 with gastric cancer, and 8 with carcinomatosis from other origins) underwent 209 consecutive procedures. Four patients underwent the intervention twice because of disease relapse. There were 70 men and 135 women. Mean age was 52 years (range, 22-76 yrs). CRS was performed by using peritonectomy procedures. IPHP through the closed abdomen technique was conducted with a preheated (42.5 degrees C) perfusate containing cisplatin + mitomycin C or cisplatin + doxorubicin. Major morbidity rate was 12%. The most significant complications were 23 anastomotic leaks or bowel perforations, 4 abdominal bleeds, and 4 sepses. Operative mortality rate was 0.9%. On logistic regression model multivariate analysis, extent of cytoreduction (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.29-6.40) and dose of cisplatin for IPHP > or = 240 mg (OR, 3.13; 95% CI, 1.24-7.90) were independent risk factors for major morbidity. Ten patients presented with Grade 3 to 4 toxicity. CRS + IPHP presented acceptable morbidity, toxicity, and mortality rates, all of which support prospective Phase III clinical trials. JF - Cancer AU - Kusamura, Shigeki AU - Younan, Rami AU - Baratti, Dario AU - Costanzo, Pasqualina AU - Favaro, Myriam AU - Gavazzi, Cecilia AU - Deraco, Marcello AD - Department of Surgery, National Cancer Institute of Milan, Milan, Italy. Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1144 EP - 1153 VL - 106 IS - 5 SN - 0008-543X, 0008-543X KW - Mitomycin KW - 50SG953SK6 KW - Doxorubicin KW - 80168379AG KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Neoplasm Recurrence, Local KW - Mitomycin -- administration & dosage KW - Infusions, Parenteral KW - Morbidity KW - Male KW - Female KW - Cisplatin -- administration & dosage KW - Hyperthermia, Induced KW - Peritoneal Neoplasms -- surgery KW - Peritoneal Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67688149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Psychotherapy+and+Counselling&rft.atitle=The+HoST+programme%3A+A+pilot+evaluation+of+modified+dialectical+behaviour+therapy+with+female+offenders+diagnosed+with+borderline+personality+disorder&rft.au=Gee%2C+Joanna%3BReed%2C+Simon&rft.aulast=Gee&rft.aufirst=Joanna&rft.date=2013-09-01&rft.volume=15&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Psychotherapy+and+Counselling&rft.issn=13642537&rft_id=info:doi/10.1080%2F13642537.2013.810659 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. AN - 67687356; 16495727 AB - This study assessed the effects of nicotine pre-exposure on subsequent locomotor and rewarding effects of repeated Delta-9-tetrahydrocannabinol administration in Sprague-Dawley rats. Repeated administration of the same dose of Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) did not produce significant tolerance or behavioral sensitization to Delta-9-tetrahydrocannabinol's locomotor effects. An unbiased place conditioning paradigm was then used to obtain a measure of the rewarding effects of Delta-9-tetrahydrocannabinol. Rats received an injection of either Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials) of a two-compartment apparatus. Control rats received saline injections associated with both compartments. Significant conditioned place preferences developed with 0.1 mg/kg Delta-9-tetrahydrocannabinol in control rats, but not in nicotine pre-exposed rats. Surprisingly, significant place aversions developed at higher 1 and 2 mg/kg doses of Delta-9-tetrahydrocannabinol in nicotine pre-exposed rats. To the extent that behavioral sensitization may reflect reward processes in drug dependence, the lack of behavioral sensitization on repeated Delta-9-tetrahydrocannabinol administration is consistent with the difficulties usually encountered in demonstrating rewarding or reinforcing effects of Delta-9-tetrahydrocannabinol in rats. The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol. JF - Behavioural pharmacology AU - Le Foll, Bernard AU - Wiggins, Marcus AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. blefoll@intra.nida.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 195 EP - 199 VL - 17 IS - 2 SN - 0955-8810, 0955-8810 KW - Hallucinogens KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Male KW - Reward KW - Nicotine -- pharmacology KW - Dronabinol -- pharmacology KW - Hallucinogens -- pharmacology KW - Motor Activity -- drug effects KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67687356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Nicotine+pre-exposure+does+not+potentiate+the+locomotor+or+rewarding+effects+of+Delta-9-tetrahydrocannabinol+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWiggins%2C+Marcus%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2006-03-01&rft.volume=17&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-06 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. AN - 67687246; 16495266 AB - Although transmissible spongiform encephalopathies (TSEs) are incurable, a key therapeutic approach is prevention of conversion of the normal, protease-sensitive form of prion protein (PrP-sen) to the disease-specific protease-resistant form of prion protein (PrP-res). Here degenerate phosphorothioate oligonucleotides (PS-ONs) are introduced as low-nM PrP-res conversion inhibitors with strong antiscrapie activities in vivo. Comparisons of various PS-ON analogs indicated that hydrophobicity and size were important, while base composition was only minimally influential. PS-ONs bound avidly to PrP-sen but could be displaced by sulfated glycan PrP-res inhibitors, indicating the presence of overlapping binding sites. Labeled PS-ONs also bound to PrP-sen on live cells and were internalized. This binding likely accounts for the antiscrapie activity. Prophylactic PS-ON treatments more than tripled scrapie survival periods in mice. Survival times also increased when PS-ONs were mixed with scrapie brain inoculum. With these antiscrapie activities and their much lower anticoagulant activities than that of pentosan polysulfate, degenerate PS-ONs are attractive new compounds for the treatment of TSEs. JF - Antimicrobial agents and chemotherapy AU - Kocisko, David A AU - Vaillant, Andrew AU - Lee, Kil Sun AU - Arnold, Kevin M AU - Bertholet, Nadine AU - Race, Richard E AU - Olsen, Emily A AU - Juteau, Jean-Marc AU - Caughey, Byron AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1034 EP - 1044 VL - 50 IS - 3 SN - 0066-4804, 0066-4804 KW - Oligonucleotides KW - 0 KW - Phosphates KW - PrPSc Proteins KW - phosphorodithioic acid KW - 8056RR93HU KW - Index Medicus KW - Injections, Intraperitoneal KW - Hydrophobic and Hydrophilic Interactions KW - Animals KW - Base Composition KW - Injections, Subcutaneous KW - Survival KW - Mice KW - Inhibitory Concentration 50 KW - Mice, Transgenic KW - Nucleic Acid Conformation KW - Molecular Weight KW - Cell Line KW - Cricetinae KW - PrPSc Proteins -- antagonists & inhibitors KW - Oligonucleotides -- pharmacology KW - Oligonucleotides -- chemistry KW - Phosphates -- chemistry KW - Scrapie -- prevention & control KW - PrPSc Proteins -- genetics KW - Oligonucleotides -- administration & dosage KW - Scrapie -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67687246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Potent+antiscrapie+activities+of+degenerate+phosphorothioate+oligonucleotides.&rft.au=Kocisko%2C+David+A%3BVaillant%2C+Andrew%3BLee%2C+Kil+Sun%3BArnold%2C+Kevin+M%3BBertholet%2C+Nadine%3BRace%2C+Richard+E%3BOlsen%2C+Emily+A%3BJuteau%2C+Jean-Marc%3BCaughey%2C+Byron&rft.aulast=Kocisko&rft.aufirst=David&rft.date=2006-03-01&rft.volume=50&rft.issue=3&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1986 Mar;67 ( Pt 3):463-73 [2419489] Neurosci Lett. 2005 Nov 11;388(2):106-11 [16039063] J Gen Virol. 1991 Feb;72 ( Pt 2):457-60 [1704414] J Gen Virol. 1992 Mar;73 ( Pt 3):661-5 [1372039] Nucleic Acids Symp Ser. 1991;(25):101-2 [1842039] J Virol. 1993 Feb;67(2):643-50 [7678300] FEBS Lett. 1993 Jun 28;325(1-2):123-7 [7685712] J Cell Physiol. 1993 Nov;157(2):319-25 [7901226] J Virol. 1994 Apr;68(4):2135-41 [7511169] Arch Virol. 1999;144(9):1751-63 [10542024] Eur J Immunol. 1999 Nov;29(11):3496-506 [10556804] J Virol. 2000 Jan;74(2):828-33 [10623745] Science. 2000 Feb 25;287(5457):1503-6 [10688802] Clin Cancer Res. 2000 May;6(5):1626-31 [10815879] J Virol. 2000 Jun;74(12):5432-40 [10823847] Immunology. 2000 Sep;101(1):46-52 [11012752] EMBO J. 2001 Feb 1;20(3):377-86 [11157745] J Biol Chem. 2001 Jun 1;276(22):19301-9 [11278562] J Pharm Biomed Anal. 1994 Nov;12(11):1345-53 [7849130] J Biol Chem. 1995 Dec 15;270(50):30221-9 [8530433] Toxicol Lett. 1995 Dec;82-83:425-30 [8597088] EMBO J. 2001 Jul 2;20(13):3351-8 [11432823] J Neurochem. 2001 Oct;79(1):79-87 [11595760] J Biol Chem. 2001 Dec 28;276(52):49400-9 [11604397] Clin Cancer Res. 2002 Mar;8(3):679-83 [11895895] J Mol Biol. 2002 Apr 19;318(1):149-59 [12054775] Lancet. 2002 Jul 20;360(9328):229-30 [12133662] J Biol Chem. 2003 Apr 4;278(14):12522-9 [12551897] J Virol. 2003 Oct;77(19):10288-94 [12970413] Br Med Bull. 2003;66:281-92 [14522865] Annu Rev Neurosci. 2003;26:267-98 [12704221] J Biol Chem. 2003 Oct 10;278(41):40041-9 [12871949] Nature. 2003 Oct 16;425(6959):717-20 [14562104] Nat Med. 2004 Feb;10(2):187-92 [14745443] J Virol. 2004 May;78(10):4999-5006 [15113880] Nat Rev Drug Discov. 2004 Oct;3(10):874-84 [15459678] J Clin Invest. 1996 Sep 1;98(5):1119-29 [8787674] FEBS Lett. 1997 Aug 18;413(2):277-81 [9280297] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83 [9811807] J Infect. 2005 Jun;50(5):394-6 [15907546] J Neurosci. 2005 May 25;25(21):5207-16 [15917460] J Biol Chem. 2005 Jul 22;280(29):26873-9 [15917229] J Chromatogr. 1990 Jun 22;509(2):396-9 [2211903] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds. AN - 67685003; 16492992 AB - In one study of children in 27 families with maternal retardation, those children with higher intelligence quotient (IQ) were more likely to have multiple behavior problems than those with lower IQ. If true, this result would affect clinical practice, but it has not been replicated. Because the setting of the initial observation is similar to the setting of childhood lead poisoning, we attempted a replication using data from the Treatment of Lead-Exposed Children (TLC) study, in which 780 children aged 12-33 mo with blood lead levels 20-44 microg/dL were randomized to either succimer treatment or placebo and then followed up to 5 y. Of 656 mothers of TLC children with IQ measured, 113 demonstrated mental retardation (IQ or=70, children with IQ >or=85 were rated more favorably on cognitive tests and behavioral questionnaires than children with IQ or=85 did not show more severe clinical behavioral problems, nor were they more likely to show multiple behavior problems. Children with higher IQ have fewer behavior problems, irrespective of the mother's IQ. In the special setting of mothers with IQ <70, children with higher IQ are not at greater risk of behavior problems. JF - Pediatric research AU - Chen, Aimin AU - Schwarz, Donald AU - Radcliffe, Jerilynn AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 471 EP - 477 VL - 59 IS - 3 SN - 0031-3998, 0031-3998 KW - Chelating Agents KW - 0 KW - Lead KW - 2P299V784P KW - Succimer KW - DX1U2629QE KW - Index Medicus KW - Lead Poisoning -- drug therapy KW - Succimer -- therapeutic use KW - Random Allocation KW - Humans KW - Mothers KW - Child KW - Intellectual Disability KW - Lead -- blood KW - Child, Preschool KW - Lead Poisoning -- physiopathology KW - Chelating Agents -- therapeutic use KW - Neuropsychological Tests KW - Female KW - Male KW - Social Environment KW - Intelligence Tests KW - Child Behavior Disorders -- physiopathology KW - Urban Population KW - Intelligence -- physiology KW - Achievement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+research&rft.atitle=Maternal+IQ%2C+child+IQ%2C+behavior%2C+and+achievement+in+urban+5-7+year+olds.&rft.au=Chen%2C+Aimin%3BSchwarz%2C+Donald%3BRadcliffe%2C+Jerilynn%3BRogan%2C+Walter+J&rft.aulast=Chen&rft.aufirst=Aimin&rft.date=2006-03-01&rft.volume=59&rft.issue=3&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Pediatric+research&rft.issn=00313998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Dec 2;402(6761 Suppl):C25-9 [10591222] Environ Health Perspect. 2005 Jul;113(7):894-9 [16002379] N Engl J Med. 2001 May 10;344(19):1421-6 [11346806] Psychol Rev. 2001 Apr;108(2):346-69 [11381833] Scand J Psychol. 2001 Dec;42(5):437-44 [11771813] J Child Psychol Psychiatry. 2004 May;45(4):779-88 [15056309] Pediatrics. 2004 Jul;114(1):19-26 [15231903] J Child Psychol Psychiatry. 1981 Oct;22(4):375-92 [7053050] Psychol Med. 1983 Nov;13(4):891-4 [6665104] J Clin Psychol. 1985 Jan;41(1):95-7 [3973047] Child Psychiatry Hum Dev. 1985 Summer;15(4):255-68 [4042738] Am J Ment Defic. 1985 Nov;90(3):253-8 [2417482] Psychopharmacol Bull. 1985;21(4):773-800 [4089106] Arch Gen Psychiatry. 1987 Sep;44(9):832-6 [3498458] Analyst. 1987 Dec;112(12):1701-4 [3445938] J Genet Psychol. 1990 Jun;151(2):139-51 [2388050] J Clin Psychol. 1992 Mar;48(2):151-64 [1573013] J Child Psychol Psychiatry. 1992 Oct;33(7):1255-61 [1400707] Am J Public Health. 1992 Oct;82(10):1356-60 [1415859] Environ Res. 1994 Apr;65(1):42-55 [8162884] BMJ. 1994 Nov 5;309(6963):1189-97 [7987149] J Child Psychol Psychiatry. 1995 Mar;36(3):409-25 [7782405] Am J Ment Retard. 1997 Jan;101(4):352-64 [9017082] Am J Public Health. 1998 Mar;88(3):481-6 [9518990] J Pediatr Psychol. 1998 Jun;23(3):197-205 [9640899] Paediatr Perinat Epidemiol. 1998 Jul;12(3):313-33 [9690266] Am J Epidemiol. 1999 Apr 15;149(8):740-9 [10206624] Psychol Bull. 1999 Jul;125(4):392-409 [10414224] J Dev Behav Pediatr. 2004 Dec;25(6):407-14 [15613989] Eur Child Adolesc Psychiatry. 1999;8 Suppl 4:41-7 [10654132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monoclonal antibodies and multifunctional cytochrome P450: drug metabolism as paradigm. AN - 67679581; 16490812 AB - Monoclonal antibodies are reagents par excellence for analyzing the role of individual cytochrome P450 isoforms in multifunctional biological activities catalyzed by cytochrome P450 enzymes. The precision and utility of the monoclonal antibodies have heretofore been applied primarily to studies of human drug metabolism. The unique and precise specificity and high inhibitory activity toward individual cytochrome P450s make the monoclonal antibodies extraordinary tools for identifying and quantifying the role of each P450 isoform in the metabolism of a drug or nondrug xenobiotic. The monoclonal antibodies identify drugs metabolized by individual, several, or polymorphic P450s. A comprehensive collection of monoclonal antibodies has been isolated to human P450s: 1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C family, 2C19, 2D6, 2E1, 3A4/5, and 2J2. The monoclonal antibodies can also be used for identifying drugs and/or metabolites useful as markers for in vivo phenotyping. Clinical identification of a patient's phenotype, coupled with precise knowledge of a drug's metabolism, should lead to a reduction of adverse drug reactions and improved drug therapeutics, thereby promoting advances in drug discovery. JF - Journal of clinical pharmacology AU - Gelboin, Harry V AU - Krausz, Kristopher AD - Laboratory of Metabolism, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892-0001, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 353 EP - 372 VL - 46 IS - 3 SN - 0091-2700, 0091-2700 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - Pharmaceutical Preparations KW - Protein Isoforms KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Phenotype KW - Alleles KW - Humans KW - Pharmaceutical Preparations -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Microsomes, Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- physiology KW - Inactivation, Metabolic -- physiology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Inactivation, Metabolic -- genetics KW - Antibodies, Monoclonal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Disorders&rft.atitle=The+specific+role+of+childhood+abuse%2C+parental+bonding%2C+and+family+functioning+in+female+adolescents+with+borderline+personality+disorder&rft.au=Infurna%2C+Maria+Rita%3BBrunner%2C+Romuald%3BHolz%2C+Birger%3BParzer%2C+Peter%3BGiannone%2C+Francesca%3BReichl%2C+Corinna%3BFischer%2C+Gloria%3BResch%2C+Franz%3BKaess%2C+Michael&rft.aulast=Infurna&rft.aufirst=Maria&rft.date=2016-04-01&rft.volume=30&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Disorders&rft.issn=0885579X&rft_id=info:doi/10.1521%2Fpedi_2015_29_186 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-06 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. AN - 67677468; 16043203 AB - Indole-3-carbinol (I-3-C) and 3,3'-diindolylmethane (DIM) have been shown to reduce the incidence and multiplicity of cancers in laboratory animal models. Based on the observation that I-3-C induced hepatocyte hypertrophy when administered orally for 13 weeks to rats, a treatment and recovery study was undertaken to test the hypothesis that the induction of hepatocyte hypertrophy and cytochrome P450 (CYP) activity by I-3-C are adaptive, reversible responses. Additionally, we directly compared the effects of I-3-C to those of its principle metabolite DIM. Rats were treated orally for 28 days with 2 doses of I-3-C (5 and 50 mg I-3-C/kg body weight/day) and DIM (7.5 and 75 mg DIM/kg body weight/day) and then one-half of the animals were not treated for an additional 28 days. Organ weights, histopathology, and the CYP enzyme activities of 1A1/2, 2B1/2, 2C9, 2D6, 2E1, 3A4, and 19 A were measured both after treatment and after recovery. Oral administration of 50 mg I-3-C/kg body weight/day to rats for 28 days significantly increased liver weights and CYP enzyme activities. The effects in males were more pronounced and persistent after recovery than the effects in females. The increased organ weights returned to control values after treatment. Conversely, DIM did not alter liver weights and had no effect on CYP activities after the 28-day treatment. Some changes in CYP activities were measured after the DIM recovery period but the magnitudes of the changes were considered biologically insignificant. The results show that I-3-C, but not DIM, induces reversible adaptive responses in the liver. JF - Toxicology and applied pharmacology AU - Crowell, James A AU - Page, John G AU - Levine, Barry S AU - Tomlinson, Michael J AU - Hebert, Charles D AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7322, USA. jc94@nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 115 EP - 123 VL - 211 IS - 2 SN - 0041-008X, 0041-008X KW - Indoles KW - 0 KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - indole-3-carbinol KW - C11E72455F KW - Aldehyde Reductase KW - EC 1.1.1.21 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - 3,3'-diindolylmethane KW - SSZ9HQT61Z KW - Index Medicus KW - Administration, Oral KW - Prostate -- drug effects KW - Animals KW - Kidney -- pathology KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Glutathione Transferase -- metabolism KW - Prostate -- metabolism KW - Kidney -- drug effects KW - Spleen -- pathology KW - Cell Enlargement -- drug effects KW - Aldehyde Reductase -- metabolism KW - Metabolic Detoxication, Phase II -- physiology KW - Uterus -- drug effects KW - Isoenzymes -- metabolism KW - Uterus -- metabolism KW - Rats KW - Toxicity Tests, Chronic -- methods KW - Rats, Sprague-Dawley KW - Spleen -- drug effects KW - Time Factors KW - Female KW - Male KW - Organ Size -- drug effects KW - Hepatocytes -- drug effects KW - Indoles -- toxicity KW - Hepatocytes -- ultrastructure KW - Indoles -- administration & dosage KW - Indoles -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Hepatocytes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67677468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Indole-3-carbinol%2C+but+not+its+major+digestive+product+3%2C3%27-diindolylmethane%2C+induces+reversible+hepatocyte+hypertrophy+and+cytochromes+P450.&rft.au=Crowell%2C+James+A%3BPage%2C+John+G%3BLevine%2C+Barry+S%3BTomlinson%2C+Michael+J%3BHebert%2C+Charles+D&rft.aulast=Crowell&rft.aufirst=James&rft.date=2006-03-01&rft.volume=211&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-19 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. AN - 67672162; 16426829 AB - There is increasing evidence that dysregulation of energy homeostasis is associated with colorectal carcinogenesis. Epidemiological data have consistently demonstrated a positive relation between increased body size and colorectal malignancy, whereas mechanistic studies have sought to uncover obesity-related carcinogenic pathways. The phenomenon of "insulin resistance" or the impaired ability to normalize plasma glucose levels has formed the core of these pathways, but other mechanisms have also been advanced. Obesity-induced insulin resistance leads to elevated levels of plasma insulin, glucose and fatty acids. Exposure of the colonocyte to heightened concentrations of insulin may induce a mitogenic effect within these cells, whereas exposure to glucose and fatty acids may induce metabolic perturbations, alterations in cell signaling pathways and oxidative stress. The importance of chronic inflammation in the pathogenesis of obesity has recently been highlighted and may represent an additional mechanism linking increased adiposity to colorectal carcinogenesis. This review provides an overview of the epidemiology of body size and colorectal neoplasia and outlines current knowledge of putative mechanisms advanced to explain this relation. Family based studies have shown that the propensity to become obese is heritable, but this is only manifest in conditions of excess energy intake over expenditure. Inheritance of a genetic profile that predisposes to increased body size may also be predictive of colorectal cancer. Genomewide scans, linkage studies and candidate gene investigations have highlighted more than 400 chromosomal regions that may harbor variants that predispose to increased body size. The genetics underlying the pathogenesis of obesity are likely to be complex, but variants in a range of different genes have already been associated with increased body size and insulin resistance. These include genes encoding elements of insulin signaling, adipocyte metabolism and differentiation, and regulation of energy expenditure. A number of investigators have begun to study genetic variants within these pathways in relation to colorectal neoplasia, but at present data remain limited to a handful of studies. These pathways will be discussed with particular reference to genetic polymorphisms that have been associated with obesity and insulin resistance. JF - The Journal of nutritional biochemistry AU - Gunter, Marc J AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA. gunterm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 145 EP - 156 VL - 17 IS - 3 SN - 0955-2863, 0955-2863 KW - Insulin KW - 0 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Insulin-Like Growth Factor II KW - 67763-97-7 KW - Growth Hormone KW - 9002-72-6 KW - Index Medicus KW - Animals KW - Humans KW - Energy Metabolism -- genetics KW - Insulin -- genetics KW - Insulin-Like Growth Factor II -- genetics KW - Insulin -- metabolism KW - Cell Differentiation -- genetics KW - Exercise KW - Inflammation KW - Insulin-Like Growth Factor I -- genetics KW - Growth Hormone -- genetics KW - Signal Transduction -- genetics KW - Adipocytes -- metabolism KW - Chronic Disease KW - Insulin Resistance KW - Diet KW - Body Size KW - Colonic Neoplasms -- epidemiology KW - Colonic Neoplasms -- genetics KW - Obesity -- genetics KW - Colonic Neoplasms -- complications KW - Obesity -- epidemiology KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67672162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=Obesity+and+colorectal+cancer%3A+epidemiology%2C+mechanisms+and+candidate+genes.&rft.au=Gunter%2C+Marc+J%3BLeitzmann%2C+Michael+F&rft.aulast=Gunter&rft.aufirst=Marc&rft.date=2006-03-01&rft.volume=17&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=09552863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-06 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Allyl sulfur compounds from garlic modulate aberrant crypt formation. AN - 67669952; 16484579 AB - The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided. JF - The Journal of nutrition AU - Ross, Sharon A AU - Finley, John W AU - Milner, John A AD - Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Rockville, MD 20892-7328, USA. rosssha@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 852S EP - 854S VL - 136 IS - 3 Suppl SN - 0022-3166, 0022-3166 KW - Anticarcinogenic Agents KW - 0 KW - Plant Extracts KW - Sulfinic Acids KW - Index Medicus KW - Animals KW - Adenoma -- prevention & control KW - Sulfinic Acids -- therapeutic use KW - Disease Models, Animal KW - Rodentia KW - Anticarcinogenic Agents -- therapeutic use KW - Precancerous Conditions -- prevention & control KW - Plant Extracts -- therapeutic use KW - Garlic KW - Colonic Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67669952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Development&rft.atitle=Prosocial+behavior%3A+Long%E2%80%90term+trajectories+and+psychosocial+outcomes&rft.au=Flynn%2C+Elinor%3BEhrenreich%2C+Samuel+E.%3BBeron%2C+Kurt+J.%3BUnderwood%2C+Marion+K.&rft.aulast=Flynn&rft.aufirst=Elinor&rft.date=2015-08-01&rft.volume=24&rft.issue=3&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Social+Development&rft.issn=0961205X&rft_id=info:doi/10.1111%2Fsode.12100 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74. Phase II study. AN - 67665479; 16175356 AB - Febrile neutropenia (FN) remains a potentially life-threatening complication of anticancer chemotherapy. Bacterial translocation via intestinal mucosa is a significant mechanism of FN development. Competitive inhibition of bowel colonization by pathogenic microorganisms by lactic acid bacteria could be a useful prevention of FN. The aim of the study was the prevention of FN by probiotic strain Enterococcus faecium M-74 enriched with selenium in leukemic patients. Fourteen (six males/eight females) patients with myelogenous leukemia treated by induction or consolidation chemotherapy were included in the study. Patients received prophylaxis with E. faecium M-74 during one cycle of chemotherapy. The daily dose was 36 x 10(9) CFU tid. Prophylaxis started between day -2 and day +2 of chemotherapy and continued until the absolute neutrophile count (ANC) was >1,000/microl. All patients experienced febrile neutropenia. During 231 days of severe neutropenia, 30 febrile episodes occurred. No any febrile episode or infection provoked by the strain tested was noticed. Tolerance of therapy was excellent without significant adverse effects. Our results demonstrate the safety of the probiotic strain E. faecium M-74 enriched with selenium in leukemic patients with severe neutropenia. However, its administration was not effective in the prevention of febrile neutropenia, but this does not preclude the protective effect of other probiotic strains. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Mego, M AU - Koncekova, R AU - Mikuskova, E AU - Drgona, L AU - Ebringer, L AU - Demitrovicova, L AU - Nemova, I AU - Trupl, J AU - Mardiak, J AU - Koza, I AU - Zajac, V AD - Department of Medical Oncology, National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovakia. misomego@mediclub.sk Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 285 EP - 290 VL - 14 IS - 3 SN - 0941-4355, 0941-4355 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Slovakia -- epidemiology KW - Middle Aged KW - Male KW - Female KW - Fever -- prevention & control KW - Fever -- complications KW - Neutropenia -- epidemiology KW - Neutropenia -- complications KW - Neutropenia -- prevention & control KW - Neutropenia -- chemically induced KW - Probiotics -- therapeutic use KW - Enterococcus faecium KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67665479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Prevention+of+febrile+neutropenia+in+cancer+patients+by+probiotic+strain+Enterococcus+faecium+M-74.+Phase+II+study.&rft.au=Mego%2C+M%3BKoncekova%2C+R%3BMikuskova%2C+E%3BDrgona%2C+L%3BEbringer%2C+L%3BDemitrovicova%2C+L%3BNemova%2C+I%3BTrupl%2C+J%3BMardiak%2C+J%3BKoza%2C+I%3BZajac%2C+V&rft.aulast=Mego&rft.aufirst=M&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. AN - 67658244; 16476034 AB - We examined the toxicity and biodistribution associated with a single administration of a first-generation, serotype 5, adenoviral vector encoding human growth hormone (hGH; AdCMVhGH) to a single rat submandibular gland in the presence of hydroxychloroquine (HCQ). Previously, we showed that hGH is primarily secreted into saliva (approximately ninefold serum level) when expressed as a transgene in salivary glands (e.g. Baum et al, 1999), but administration of HCQ substantially increases the hGH levels secreted into the bloodstream (Hoque et al, 2001). A potential application of this observation is for patients with adult hGH deficiency. Six groups of male and female adult rats (n = 12 each) were studied, with zero to 1.5 x 10(11) particles of AdCMVhGH, +/-HCQ, administered retroductally. Multiple clinical and pathological parameters, as well as vector tissue distribution, were assessed. All animals survived until the scheduled day of sacrifice, and essentially no untoward events were observed clinically or at gross necropsy. We observed no vector-related effects on clinical hematology evaluations and a single, transient significant change on clinical chemistry evaluations (increased serum globulin levels). Three days after AdCMVhGH administration, the vector distributed to all tissues analyzed with the exception of gonads and heart. By day 29, most organs, other than the targeted and contralateral submandibular glands, were negative for the presence of vector. On day 3, none of the animals tested positive for the presence of replication competent adenovirus in either their blood or saliva. Salivary gland delivery of AdCMVhGH +/-HCQ appears associated with limited toxicity in rats. JF - Oral diseases AU - Zheng, C AU - Voutetakis, A AU - Kok, M R AU - Goldsmith, C M AU - Smith, G B J AU - Elmore, S AU - Nyska, A AU - Vallant, M AU - Irwin, R D AU - Baum, B J AD - Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD 20892-1190, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 137 EP - 144 VL - 12 IS - 2 SN - 1354-523X, 1354-523X KW - Antirheumatic Agents KW - 0 KW - Recombinant Proteins KW - Serum Globulins KW - Human Growth Hormone KW - 12629-01-5 KW - Hydroxychloroquine KW - 4QWG6N8QKH KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Amylases KW - EC 3.2.1.- KW - Dentistry KW - Virus Replication KW - Animals KW - Plasmids -- genetics KW - Humans KW - Tissue Distribution KW - Alkaline Phosphatase -- blood KW - Rats KW - Alanine Transaminase -- blood KW - Rats, Inbred F344 KW - L-Lactate Dehydrogenase -- blood KW - Amylases -- blood KW - Serum Globulins -- analysis KW - Female KW - Male KW - Submandibular Gland -- metabolism KW - Human Growth Hormone -- toxicity KW - Human Growth Hormone -- genetics KW - Hydroxychloroquine -- pharmacology KW - Submandibular Gland -- drug effects KW - Antirheumatic Agents -- pharmacology KW - Genetic Vectors -- genetics KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67658244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+diseases&rft.atitle=Toxicity+and+biodistribution+of+a+first-generation+recombinant+adenoviral+vector%2C+in+the+presence+of+hydroxychloroquine%2C+following+retroductal+delivery+to+a+single+rat+submandibular+gland.&rft.au=Zheng%2C+C%3BVoutetakis%2C+A%3BKok%2C+M+R%3BGoldsmith%2C+C+M%3BSmith%2C+G+B+J%3BElmore%2C+S%3BNyska%2C+A%3BVallant%2C+M%3BIrwin%2C+R+D%3BBaum%2C+B+J&rft.aulast=Zheng&rft.aufirst=C&rft.date=2006-03-01&rft.volume=12&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Oral+diseases&rft.issn=1354523X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deamidation of peptides in aerobic nitric oxide solution by a nitrosative pathway. AN - 67630435; 16249103 AB - Hydrolytic deamidation of asparagine (Asn) and glutamine (Gln) residues to aspartate (Asp) and glutamate (Glu), respectively, can have significant biological consequences. We hypothesize that a wholly different mechanism of deamidation might occur in the presence of aerobic nitric oxide (NO). Accordingly, we examined the deamidating ability of aerobic NO toward three model peptides, 2,4-dinitrophenyl (DNP)-Pro-Gln-Gly, Lys-Trp-Asp-Asn-Gln, and Ser-Glu-Asn-Tyr-Pro-Ile-Val, incubating them with the NO-generating compound, Et(2)N[N(O)NO]Na (DEA/NO, 30-48 mM), in aerobic, pH 7.4, buffer at 37 degrees C. DNP-Pro-Glu-Gly was detected after 2 h, while Lys-Trp-Asp-Asp-Gln, Lys-Trp-Asp-Asn-Glu, and Ser-Glu-Asp-Tyr-Pro-Ile-Val were detected within 10 min, accumulating in apparent yields of up to approximately 10%. In the latter case, tyrosine nitration was also observed, producing the expected nitrotyrosine residue. DEA/NO solutions preincubated to exhaust the NO before the peptides were added did not induce detectable deamidation. The data demonstrate that aerobic NO exposures can lead to nitrosative deamidation of peptides, a pathway that differs from the established hydrolytic deamidation mechanism in several key respects: the by-products of the former are molecular nitrogen and an acid (HONO) while that of the latter is a base (NH(3)); the nitrosative path can in principle proceed in the absence of water molecules; Asn is much more easily deamidated than Gln in the hydrolytic pathway, while the two amino acid residues were deamidated to a similar extent by exposure to NO in the presence of oxygen. JF - Nitric oxide : biology and chemistry AU - Kong, Li AU - Saavedra, Joseph E AU - Buzard, Gregory S AU - Xu, Xia AU - Hood, Brian L AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 144 EP - 151 VL - 14 IS - 2 SN - 1089-8603, 1089-8603 KW - Amino Acids KW - 0 KW - Macromolecular Substances KW - Peptides KW - Pharmaceutical Preparations KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Models, Chemical KW - Amino Acids -- chemistry KW - Peptides -- metabolism KW - Peptides -- chemistry KW - Nitric Oxide -- physiology KW - Amino Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67630435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Deamidation+of+peptides+in+aerobic+nitric+oxide+solution+by+a+nitrosative+pathway.&rft.au=Kong%2C+Li%3BSaavedra%2C+Joseph+E%3BBuzard%2C+Gregory+S%3BXu%2C+Xia%3BHood%2C+Brian+L%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BKeefer%2C+Larry+K&rft.aulast=Kong&rft.aufirst=Li&rft.date=2006-03-01&rft.volume=14&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=10898603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-16 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A lifetime of caring: Dimensions and dynamics in late-life close relationships AN - 61582524; 200704645 AB - This review of research on close relationships in old age is informed by principles of life span developmental psychology and life course theory in sociology. It begins with an elaboration of life span and life course concepts as applied to relationships and an analysis of the multiple forms that caring can take. The discussion continues with presentation of research on the effects of sociohistorical contexts on relationships in old age and studies of the effects of personal development and life events on relationships as well. A section examining problems in late-life close relationships is followed by examples of new directions for research on the intersections of personal development and close relationships. Figures, References. Adapted from the source document. JF - Personal Relationships AU - Blieszner, Rosemary AD - aVirginia Polytechnic Institute and State University Rosemary Blieszner, Alumni Distinguished Professor, is a Professor of Gerontology and Family Studies in the Department of Human Development and Associate Director of the Center for Gerontology at Virginia Polytechnic Institute and State University, Blacksburg. She received her Ph.D. from the Pennsylvania State University in Human Development-Family Studies with a major concentration in adult development and aging and a minor in sociology/social psychology. Her doctoral education was supported by the U. S. Administration on Aging and the National Institute on Aging. Her research, funded by the U. S. Administration on Aging, U. S. Departments of Health and Human Services and Agriculture, AARP Andrus Foundation, Alzheimer's Association, Virginia Tech ASPIRES Program, Virginia Tech Women's Research Institute, and Virginia Tech Educational Foundation, focuses on family and friend relationships, life events, and psycholog Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 1 EP - 18 PB - Blackwell Publishing, Malden MA VL - 13 IS - 1 SN - 1350-4126, 1350-4126 KW - Friendship KW - Life History KW - Interpersonal Relations KW - Elderly KW - Life Events KW - article KW - 0665: complex organization; social network analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61582524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personal+Relationships&rft.atitle=A+lifetime+of+caring%3A+Dimensions+and+dynamics+in+late-life+close+relationships&rft.au=Blieszner%2C+Rosemary&rft.aulast=Blieszner&rft.aufirst=Rosemary&rft.date=2006-03-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Personal+Relationships&rft.issn=13504126&rft_id=info:doi/10.1111%2Fj.1475-6811.2006.00101.x LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PRRLEY N1 - SubjectsTermNotLitGenreText - Life Events; Life History; Elderly; Friendship; Interpersonal Relations DO - http://dx.doi.org/10.1111/j.1475-6811.2006.00101.x ER - TY - JOUR T1 - Untangling the Web: A Close Look at Diagnosis Disclosure among HIV-Infected Adolescents AN - 57214640; 200613744 AB - As children living with human immunodeficiency virus (HIV) survive into adolescence & young adulthood, attention to the relationship of diagnosis disclosure to psychological functioning, interpersonal relationships, & HIV prevention is needed. This exploratory study describes the level of adolescents' diagnosis disclosure to family, friends, & potential sexual partners, & the relationship between disclosure & psychosocial variables. 2 Tables, 10 References. [Copyright 2006 The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wiener, Lori S AU - Battles, Haven B AD - National Cancer Instit, Bethesda, MD wienerl@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 307 EP - 309 PB - Elsevier, New York NY VL - 38 IS - 3 SN - 1054-139X, 1054-139X KW - HIV-positive adolescents KW - Diagnosis disclosure KW - Posttraumatic stress symptoms KW - Psychological distress KW - Interpersonal relationships KW - Young adults KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57214640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Mental+Health&rft.atitle=Treatment+of+borderline+personality+disorder+with+schizotypal+traits&rft.au=Maffei%2C+Cesare&rft.aulast=Maffei&rft.aufirst=Cesare&rft.date=2010-08-01&rft.volume=4&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Personality+and+Mental+Health&rft.issn=19328621&rft_id=info:doi/10.1002%2Fpmh.136 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - HIV; Young adults; Interpersonal relationships DO - http://dx.doi.org/10.1016/j.jadohealth.2005.03.024 ER - TY - JOUR T1 - Maturing Out of Alcohol Dependence: The Impact of Transitional Life Events AN - 57203510; 200608254 AB - Objective: The purpose of this study was to investigate the effects of transitional life events related to education, employment, & family formation on the likelihood of recovery from alcohol dependence as defined by the Diagnostic & Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), distinguishing the short- & long-term effects of these events & potential effect modification by treatment history, gender, & severity of dependence. Method: This analysis is based on data from the Wave 1 2001-2002 National Epidemiologic Survey on Alcohol & Related Conditions (NESARC), a cross-sectional, retrospective survey of a nationally representative sample of U.S. adults 18 years of age & older. The analytic sample consisted of 4,422 individuals with prior-to-past-year (PPY) onset of DSM-IV alcohol dependence. Time-dependent proportional hazards models were used to estimate the effects of completing school, starting full-time work, getting married, becoming separated/divorced/widowed, & becoming a parent on the outcomes of nonabstinent recovery (NR; e.g., low-risk asymptomatic drinking) & abstinent recovery (AR). Results: Entry into & exit from a first marriage each increased the likelihood of NR during the first 3 years after those events occurred (hazard rate ratio [HRRI = 1.37 & 1.76, respectively). However, individuals who were still dependent 3 or more years after those events occurred had a decreased likelihood of subsequent NR (HRR = 0.70 for both events), as did those who were still dependent 3 or more years after completing schooling (HRR = 0.54). The likelihood of AR was more than doubled in the 3 years after first becoming a parent (HRR = 2.22) but was decreased among individuals still dependent 3 or more years after starting full-time work. For the outcome of NR, all of the negative effects associated with still being dependent 3 or more years after the occurrence of key life events were more strongly negative among individuals with less severe eases of dependence. Conclusions: Transitional life events demonstrate many effects on recovery, including both direct effects consistent with role socialization & associations more reflective of selectivity than causation. Taken as a whole, these events appear to contribute to (but by no means fully explain) the high rates of recovery from alcohol dependence that have been observed even in the absence of treatment. 3 Tables, 45 References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - Dawson, Deborah A AU - Grant, Bridget F AU - Stinson, Frederick S AU - Chou, Patricia S AD - Laboratory Epidemiology & Biometry, Division Intramural Clinical & Biological Research, National Instit Alco ddawson@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 195 EP - 203 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 67 IS - 2 SN - 0096-882X, 0096-882X KW - Education KW - Alcohol Dependence KW - Family Development KW - Life Events KW - Employment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57203510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Maturing+Out+of+Alcohol+Dependence%3A+The+Impact+of+Transitional+Life+Events&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BStinson%2C+Frederick+S%3BChou%2C+Patricia+S&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2006-03-01&rft.volume=67&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Alcohol Dependence; Life Events; Education; Employment; Family Development ER - TY - JOUR T1 - Triadic Model of the Neurobioglogy of Motivated Behavior in Adolescence AN - 57175071; 200608394 AB - Background. Risk-taking behavior is a major cause of morbidity & mortality in adolescence. In the context of decision theory & motivated (goal-directed) behavior, risk-taking reflects a pattern of decision-making that favors the selection of courses of action with uncertain & possibly harmful consequences. We present a triadic, neuroscience systems-based model of adolescent decision-making. Method. We review the functional role & neurodevelopmental findings of three key structures in the control of motivated behavior, i.e. amygdala, nucleus accumbens, & medial/ventral prefrontal cortex. We adopt a cognitive neuroscience approach to motivated behavior that uses a temporal fragmentation of a generic motivated action. Predictions about the relative contributions of the triadic nodes to the three stages of a motivated action during adolescence are proposed. Results. The propensity during adolescence for reward/novelty seeking in the face of uncertainty or potential harm might be explained by a strong reward system (nucleus accumbens), a weak harm-avoidant system (amygdala), &/or an inefficient supervisory system (medial/ventral prefrontal cortex). Perturbations in these systems may contribute to the expression of psychopathology, illustrated here with depression & anxiety. Conclusions. A triadic model, integrated in a temporally organized map of motivated behavior, can provide a helpful framework that suggests specific hypotheses of neural bases of typical & atypical adolescent behavior. 2 Figures, 151 References. Adapted from the source document. JF - Psychological Medicine AU - Ernst, Monique AU - Pine, Daniel S AU - Hardin, Michael AD - Section Developmental & Affective Neuroscience, Mood & Anxiety Disorders Program, National Instit Mental Hea ernstm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 299 EP - 312 PB - Cambridge U Press, UK VL - 36 IS - 3 SN - 0033-2917, 0033-2917 KW - Systemic models KW - Decision making KW - Motivation KW - Neurobiology KW - Risk taking KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57175071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Triadic+Model+of+the+Neurobioglogy+of+Motivated+Behavior+in+Adolescence&rft.au=Ernst%2C+Monique%3BPine%2C+Daniel+S%3BHardin%2C+Michael&rft.aulast=Ernst&rft.aufirst=Monique&rft.date=2006-03-01&rft.volume=36&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291705005891 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Adolescents; Decision making; Systemic models; Neurobiology; Motivation; Risk taking DO - http://dx.doi.org/10.1017/S0033291705005891 ER - TY - JOUR T1 - What Do Two-Year-Old Understand about Hidden-Object Events? AN - 57161076; 200609113 AB - Preferential-looking studies suggest that by 2 months of age, infants may have knowledge about some object properties, such as solidity. Manual search studies of toddlers examining these same concepts, however, have failed to provide evidence for the same understanding. Investigators have recently attempted to reconcile this disparity but failed to control for the visual novelty of test outcomes. The current design corrected this problem & also tested toddlers' predictions of the object's location. The task involved the same events & apparatus that have been used in manual search tasks but used looking as the dependent measure. Children looked longer when an agent opened the correct door & found no ball than when an incorrect door was opened to reveal no ball. A 2nd experiment indicated that children's preferential-looking performance did not differ from that in manual search tasks simply because additional response time had been allowed to respond. Previous comparisons of looking versus reaching tested children's postdiction response to an object in an unexpected location, but these findings indicate that toddlers can predict where the object should be. 4 Figures, 37 References. [Copyright 2006 American Psychological Association] JF - Developmental Psychology AU - Mash, Clay AU - Novak, Elizabeth AU - Berthier, Neil E AU - Keen, Rachel AD - NICHD Section Child & Family Research, Bethesda, MD mashc@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 263 EP - 271 PB - American Psychological Association, Washington DC VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - reasoning, manual search, toddlers, development KW - Reasoning KW - Hidden objects KW - Development KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57161076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Psychology&rft.atitle=What+Do+Two-Year-Old+Understand+about+Hidden-Object+Events%3F&rft.au=Mash%2C+Clay%3BNovak%2C+Elizabeth%3BBerthier%2C+Neil+E%3BKeen%2C+Rachel&rft.aulast=Mash&rft.aufirst=Clay&rft.date=2006-03-01&rft.volume=42&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Developmental+Psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.42.2.263 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-28 N1 - Last updated - 2016-09-27 N1 - CODEN - DEVPA9 N1 - SubjectsTermNotLitGenreText - Children; Hidden objects; Reasoning; Development DO - http://dx.doi.org/10.1037/0012-1649.42.2.263 ER - TY - JOUR T1 - Reward and Punishment Sensitivity in Shy and Non-Shy Adults: Relations between Social and Motivated Behavior AN - 57150046; 200606611 AB - Few studies have examined underlying mechanisms linking social behavior, motivated behavior, & reward & punishment systems. The current study was designed to investigate these mechanisms by examining responses to both rewarding & punishing non-social stimuli in shy & non-shy adults. Ninety-three participants, comprising three social behavior groups (Shy, Non-shy, Control) completed the Monetary Incentive Delay task. Consistent with previous research, all participants were sensitive to incentive manipulations. There were also significant individual differences in response. Non-shy participants demonstrated sensitivity to both reward & punishment stimuli, & behavior indicative of high levels of arousal in approach motivation. Shy individuals demonstrated a large discrepancy in sensitivity to reward compared to punishment, with this discrepancy being driven by enhanced sensitivity to reward. Their behavior suggested conflict generated by increased arousal in both approach & withdrawal motivation systems. Current findings contribute to theoretical accounts of relations between social behavior & behavior modulated by reward & punishment. These findings carry implications for the study of psychopathology & neuroimaging research designed to examine relationships between social behavior, motivated behavior, & underlying reward & punishment systems. 3 Tables, 3 Figures, 42 References. [Copyright 2005 Elsevier Ltd.] JF - Personality and Individual Differences AU - Hardin, Michael G AU - Perez-Edgar, Koraly AU - Guyer, Amanda E AU - Pine, Daniel S AU - Fox, Nathan A AU - Ernst, Monique AD - Section Development & Affective Neuroscience, National Instit Mental Health, NIH/DHHS, Bethesda, MD hardinm@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 699 EP - 711 PB - Elsevier, UK VL - 40 IS - 4 SN - 0191-8869, 0191-8869 KW - Motivation KW - Reward KW - Punishment KW - Social behavior KW - Shyness KW - Anxiety KW - Behavioral inhibition KW - Inhibited behaviour KW - Social behaviour KW - Extrinsic motivation KW - Incentives KW - Shy people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57150046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Individual+Differences&rft.atitle=Reward+and+Punishment+Sensitivity+in+Shy+and+Non-Shy+Adults%3A+Relations+between+Social+and+Motivated+Behavior&rft.au=Hardin%2C+Michael+G%3BPerez-Edgar%2C+Koraly%3BGuyer%2C+Amanda+E%3BPine%2C+Daniel+S%3BFox%2C+Nathan+A%3BErnst%2C+Monique&rft.aulast=Hardin&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=40&rft.issue=4&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Personality+and+Individual+Differences&rft.issn=01918869&rft_id=info:doi/10.1016%2Fj.paid.2005.08.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PEIDD9 N1 - SubjectsTermNotLitGenreText - Incentives; Extrinsic motivation; Shy people; Punishment; Social behaviour; Inhibited behaviour DO - http://dx.doi.org/10.1016/j.paid.2005.08.010 ER - TY - JOUR T1 - Relationship between Age and Aspects of Depression: Consistency and Reliability across Two Longitudinal Studies AN - 57072159; 200618686 AB - In this study, the authors examined cross-sectional & longitudinal age & gender differences in each of the Center for Epidemiological Studies Depression Scale's 4 subscales of depressive symptomatology. Two independent studies (Sample 1 = 2,076; Sample 2 = 943) were used for purposes of establishing stability of findings. Results indicate a reasonable degree of stability among adults under 70 years of age. However, there were significant age-related increases in somatic symptoms & lack of well-being after approximately 70 years of age, whereas symptoms related to depressed affect & interpersonal problems remained stable. Notably, depressive affect symptoms remained stable given significant age-related somatic changes. The addition of comorbid physical illness to the analysis did not reduce the association between age & depressive symptoms, indicating that part of the association was not substantially accounted for by physical health. Tables, Figures, References. [Copyright 2006 American Psychological Association.] JF - Psychology and Aging AU - Nguyen, Ha T AU - Zonderman, Alan B AD - Gerontology Research Center, National Instit Aging, Baltimore, MD nguyenha@grc.nia.nih.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 119 EP - 126 PB - American Psychological Association, Washington DC VL - 21 IS - 1 SN - 0882-7974, 0882-7974 KW - age, depression, CES-D, subscales KW - Age KW - Depression KW - Somatic symptoms KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57072159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Relationship+between+Age+and+Aspects+of+Depression%3A+Consistency+and+Reliability+across+Two+Longitudinal+Studies&rft.au=Nguyen%2C+Ha+T%3BZonderman%2C+Alan+B&rft.aulast=Nguyen&rft.aufirst=Ha&rft.date=2006-03-01&rft.volume=21&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2F0882-7974.21.1.119 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Age; Depression; Gender differences; Somatic symptoms DO - http://dx.doi.org/10.1037/0882-7974.21.1.119 ER - TY - CPAPER T1 - A Model of Neurovisceral Integration: An Overview with Implications for Health and Disease T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39931422; 4156909 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Thayer, Julian F Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Integration KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39931422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=A+Model+of+Neurovisceral+Integration%3A+An+Overview+with+Implications+for+Health+and+Disease&rft.au=Thayer%2C+Julian+F&rft.aulast=Thayer&rft.aufirst=Julian&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Neural Network of Mirror Neuron System and Mentalizing in Alexithymia T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39929349; 4157024 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Moriguchi, Yoshiya AU - Ohnishi, Takashi AU - Maeda, Motonari AU - Komaki, Gen Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Artificial intelligence KW - Neural networks KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39929349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=The+Neural+Network+of+Mirror+Neuron+System+and+Mentalizing+in+Alexithymia&rft.au=Moriguchi%2C+Yoshiya%3BOhnishi%2C+Takashi%3BMaeda%2C+Motonari%3BKomaki%2C+Gen&rft.aulast=Moriguchi&rft.aufirst=Yoshiya&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health, Diurnal Rhythm and Awakening Cortisol Response in Midterm and Late Pregnant Women T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39922463; 4157167 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Nagamine, Mitsue AU - Saito, Satoru AU - Okabayashi, Hideki AU - Kim, Yoshiharu Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Diurnal variations KW - Hydrocortisone KW - Rhythms KW - Circadian rhythms KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=Mental+Health%2C+Diurnal+Rhythm+and+Awakening+Cortisol+Response+in+Midterm+and+Late+Pregnant+Women&rft.au=Nagamine%2C+Mitsue%3BSaito%2C+Satoru%3BOkabayashi%2C+Hideki%3BKim%2C+Yoshiharu&rft.aulast=Nagamine&rft.aufirst=Mitsue&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Aspects of Alexithymia: A Japanese Community Based Study T2 - 64th Annual Scientific Conference of the American Psychosomatic Society AN - 39922072; 4157039 JF - 64th Annual Scientific Conference of the American Psychosomatic Society AU - Komaki, Gen AU - Moriguchi, Yoshiya AU - Maeda, Motonari Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 KW - Japan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.atitle=Developmental+Aspects+of+Alexithymia%3A+A+Japanese+Community+Based+Study&rft.au=Komaki%2C+Gen%3BMoriguchi%2C+Yoshiya%3BMaeda%2C+Motonari&rft.aulast=Komaki&rft.aufirst=Gen&rft.date=2006-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=64th+Annual+Scientific+Conference+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/events_annual_meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Personality and subjective well-being in orangutans (Pongo pygmaeus and pongo abelii) AN - 37721397; 3265037 AB - Orangutans (Pongo pygmaeus and Pongo abelii) are semisolitary apes and, among the great apes, the most distantly related to humans. Raters assessed 152 orangutans on 48 personality descriptors; 140 of these orangutans were also rated on a subjective well-being questionnaire. Principal-components analysis yielded 5 reliable personality factors: Extraversion, Dominance, Neuroticism, Agreeableness, and Intellect. The athors found no factor analogous to human Conscientiousness. Among the orangutans rated on all 48 personality descriptors and the subjective well-being questionnaire, Extraversion, Agreeableness, and low Neuroticism were related to subjective well-being. These findings suggest that analogues of human, chimpanzee, and orangutan personality domains existed in a common ape ancestor. Reprinted by permission of the American Psychological Association JF - Journal of personality and social psychology AU - Weiss, Alexander AU - King, James E AD - National Institutes of Health ; University of Arizona Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 501 EP - 511 VL - 90 IS - 3 SN - 0022-3514, 0022-3514 KW - Sociology KW - Animals KW - Social psychology KW - Psychology KW - Well-being KW - Personality KW - Orang-utans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37721397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Personality+and+subjective+well-being+in+orangutans+%28Pongo+pygmaeus+and+pongo+abelii%29&rft.au=Weiss%2C+Alexander%3BKing%2C+James+E&rft.aulast=Weiss&rft.aufirst=Alexander&rft.date=2006-03-01&rft.volume=90&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2F0022-3514.90.3.501 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 13530 13521; 8983 10148; 1046; 11901 10404; 10404 DO - http://dx.doi.org/10.1037/0022-3514.90.3.501 ER - TY - JOUR T1 - Depression, self-esteem, and anger in emerging adulthood: seven-year trajectories AN - 37715686; 3261998 AB - This study used a school-based community sample (N = 920) to examine trajectories of depressive symptoms, self-esteem, and expressed anger in the critical years of emerging adulthood (ages 18-25). Using data from 5 waves, the authors discovered that multilevel models indicated that, on average, depressive symptoms and expressed anger declined, whereas self-esteem increased. Between-persons predictors of variability in trajectories included gender (gender gaps in depressive symptoms and self-esteem narrowed), parents' education, and conflict with parents (depressive symptoms and expressed anger improved fastest in participants with highly educated parents and in those with higher conflict). Across time, increases in social support and marriage were associated with increased psychological well-being, whereas longer periods of unemployment were connected with higher depression and lower self-esteem. Emerging adulthood is a time of improving psychological well-being, but individual trajectories depend on specific individual and family characteristics as well as role changes. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Galambos, Nancy L AU - Barker, Erin T AU - Krahn, Harvey J AD - University of Alberta ; National Institute of Child Health and Human Development Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 350 EP - 365 VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - Sociology KW - Survey analysis KW - Depression KW - Social support KW - Adulthood KW - Time series KW - Parent-child relations KW - Sample surveys KW - Developmental psychology KW - Youth KW - Anger KW - Self-esteem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37715686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prison+Journal&rft.atitle=Whatever+is+next+after+the+prison-building+boom+will+be+next+in+Texas&rft.au=Fabelo%2C+Tony&rft.aulast=Fabelo&rft.aufirst=Tony&rft.date=1996-12-01&rft.volume=76&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=The+Prison+Journal&rft.issn=00328855&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 3439 4196 7951 6220 7954; 11473 11442 6191; 1022 4196; 13779 652 5676 646 6091; 12759 12228 10919; 11253 12429; 12426 3279 971 3286; 9178 4777 6093 6823; 11938 11949 13521; 602 652 5676 646 6091 DO - http://dx.doi.org/10.1037/0012-1649.42.2.350 ER - TY - JOUR T1 - What do two-year-olds understand about hidden-object events? AN - 37711606; 3261990 AB - Preferential-looking studies suggest that by 2 months of age, infants may have knowledge about some object properties, such as solidity. Manual search studies of toddlers examining these same concepts, however, have failed to provide evidence for the same understanding. Investigators have recently attempted to reconcile this disparity but failed to control for the visual novelty of test outcomes. The current design corrected this problem and also tested toddlers' predictions of the object's location. The task involved the same events and apparatus that have been used in manual search tasks but used looking as the dependent measure. Children looked longer when an agent opened the correct door and found no ball than when an incorrect door was opened to reveal no ball. A 2nd experiment indicated that children's preferential-looking performance did not differ from that in manual search tasks simply because additional response time had been allowed to respond. Previous comparisons of looking versus reaching tested children's postdiction response to an object in an unexpected location, but these findings indicate that toddlers can predict where the object should be. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Mash, Clay AU - Novak, Elizabeth AU - Berthier, Neil E AU - Keen, Rachel AD - National Institute of Child Health and Human Development ; University of Massachusetts Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 263 EP - 271 VL - 42 IS - 2 SN - 0012-1649, 0012-1649 KW - Sociology KW - Reasoning KW - Childhood KW - Regression analysis KW - Empirical research KW - Developmental psychology KW - Cognition KW - Object UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37711606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=What+do+two-year-olds+understand+about+hidden-object+events%3F&rft.au=Mash%2C+Clay%3BNovak%2C+Elizabeth%3BBerthier%2C+Neil+E%3BKeen%2C+Rachel&rft.aulast=Mash&rft.aufirst=Clay&rft.date=2006-03-01&rft.volume=42&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.42.2.263 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 8824; 2449 10404; 4200 10902; 2211 652 5676 646 6091 2212; 10643 10642 2688 2449 10404; 10739 12228 10919 DO - http://dx.doi.org/10.1037/0012-1649.42.2.263 ER - TY - JOUR T1 - Atrial Fibrillation among African Americans, Hispanics and Caucasians: Clinical Features and Outcomes from the AFFIRM Trial AN - 214046315; 16573295 AB - The Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study concluded that rate control with anticoagulation was equivalent overall to rhythm control with cardioversion for long-term survival and that anticoagulation reduced the risk of stroke. We compared baseline and follow-up data for three ethnic groups: Caucasians (n=3,599), African Americans (n=265) and Hispanics (n=132). Caucasians were older and more likely male, African Americans were more likely female and hypertensive, and Hispanics had higher prevalence of cardiomyopathy. Survival was better for rate control than rhythm control in Caucasians, equivalent in African Americans and better for rhythm control in Hispanics. Outcomes may be influenced by differential baseline characteristics, but low numbers of African Americans and Hispanics warrant caution in data interpretation. The AFFIRM study compared a rate-control strategy to a rhythm-control strategy for the treatment of atrial fibrillation (AF) in patients at high risk for stroke or death. It concluded that the rhythm-control strategy offered no survival advantage, and it also confirmed the value of anticoagulation to prevent complications of AF. Data have not previously been available for specific racial ethnic populations. We compared baseline and follow-up data for the patients randomized to rate-control versus rhythm-control in three population groups-Caucasian, African-American and Hispanic. Among 4,060 total patients, 3,599 were Caucasian, 265 were African-American and 132 were Hispanic. At baseline, Caucasians were older and had a higher percentage of males, normal ejection fractions, AF as their only cardiac diagnosis, a prior antiarrhythmic drug failure and less congestive heart failure. African Americans were more likely to be female, had more hypertension and qualified for the study with a first episode of AF, compared to Caucasians. Hispanics had more cardiomyopathy at baseline than Caucasians. Overall survival in Caucasians at five years for the rate-control and rhythm-control groups was 78.9% vs. 76.4%, respectively (p=0.04); for African Americans, 79.0% vs. 69.4% (p=0.22); and for Hispanics, 66.5% vs. 83.9% (p=0.01). Overall, survival was not different between the three populations. However, lower rates of event-free survival were recorded for Hispanics and for African Americans (p=0.0182). Different survival rates were found for rate-control versus rhythm-control in African-American and Hispanic patients, compared to Caucasian. These findings may be influenced by differences in baseline characteristics, but must be interpreted with caution because of the small sample sizes for African-American and Hispanic participants. JF - Journal of the National Medical Association AU - Bush, David AU - Martin, Lisa W AU - Leman, Robert AU - Chandler, Mary AU - Haywood, L Julian Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 330 EP - 9 CY - Washington PB - National Medical Association VL - 98 IS - 3 SN - 00279684 KW - Medical Sciences KW - Anticoagulants KW - Atrial Fibrillation -- mortality KW - Electric Countershock KW - Survival Rate KW - Anticoagulants -- therapeutic use KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Hispanic Americans KW - European Continental Ancestry Group KW - African Americans KW - Atrial Fibrillation -- therapy KW - Atrial Fibrillation -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/214046315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Medical+Association&rft.atitle=Atrial+Fibrillation+among+African+Americans%2C+Hispanics+and+Caucasians%3A+Clinical+Features+and+Outcomes+from+the+AFFIRM+Trial&rft.au=Bush%2C+David%3BMartin%2C+Lisa+W%3BLeman%2C+Robert%3BChandler%2C+Mary%3BHaywood%2C+L+Julian&rft.aulast=Bush&rft.aufirst=David&rft.date=2006-03-01&rft.volume=98&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Medical+Association&rft.issn=00279684&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright National Medical Association Mar 2006 N1 - Last updated - 2014-04-30 N1 - CODEN - JNMAAE ER - TY - JOUR T1 - Imaging genomics applied to anxiety, stress response, and resiliency AN - 21220615; 11280690 AB - Anxiety and stress response/resiliency are heritable traits central to the etiology of multiple psychiatric diseases, but efforts to identify genetic variation influencing this broad domain of neurobiological function are hampered by the coarseness of the phenotypic measures and the effects of environmental factors. Neuroimaging offers a powerful approach for assessing functional neuronal activity. Neurophysiological measures can serve as intermediate phenotypes more directly linked to small gene effects, compared with behavioral end points of neural dysfunction. Imaging genomics is a relatively new research area that is concerned with linking functional gene variants and brain information processing. Here, we will focus on processes affected by anxiety and stress. Neuroimaging has been combined with genetic analysis to reveal genetic effects of functional variants of the serotonin transporter (5-HTT) and catechol-O-methyltransferase (COMT) genes on brain response to stressful stimuli. The low-expressing allele of the 5-HTT promoter polymorphism (HTTLPR) is associated with anxiety and with greater amygdala and other regional responses to emotional. The COMT Met158 allele leads to lower COMT activity and has also been associated with anxiety, and the effect of this gene is apparently additive with HTTLPR. Individuals with Met158 genotypes are more sensitive to pain stress and, as shown by C Carfentanil imaging, have diminished ability to upregulate opioid release after pain/stress. These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety. JF - Neuroinformatics AU - Xu, Ke AU - Ernst, Monique AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, 5625 Fishers Lane, Room 3S32, 20852 Rockville, MD, ke@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 51 EP - 64 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 4 IS - 1 SN - 1539-2791, 1539-2791 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Emotions KW - Neuroimaging KW - Etiology KW - Anxiety KW - Gene polymorphism KW - Genetic analysis KW - Genetic diversity KW - Stress KW - Pain KW - Environmental factors KW - Mental disorders KW - Catechol O-methyltransferase KW - Information processing KW - Amygdala KW - Opioids KW - Bioinformatics KW - genomics KW - Serotonin transporter KW - G 07880:Human Genetics KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=Imaging+genomics+applied+to+anxiety%2C+stress+response%2C+and+resiliency&rft.au=Xu%2C+Ke%3BErnst%2C+Monique%3BGoldman%2C+David&rft.aulast=Xu&rft.aufirst=Ke&rft.date=2006-03-01&rft.volume=4&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1385%2FNI%3A4%3A1%3A51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Emotions; Etiology; Neuroimaging; Anxiety; Gene polymorphism; Genetic analysis; Stress; Genetic diversity; Pain; Environmental factors; Mental disorders; Catechol O-methyltransferase; Information processing; Opioids; Amygdala; genomics; Bioinformatics; Serotonin transporter DO - http://dx.doi.org/10.1385/NI:4:1:51 ER - TY - JOUR T1 - Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI AN - 21152271; 11177673 AB - The availability of structural information on glycosyltransferases is beginning to make structure-based reengineering of these enzymes possible. Mutant glycosyltransferases have been generated that can transfer a sugar residue with a chemically reactive unique functional group to a sugar moiety of glycoproteins, glycolipids, and proteoglycans (glyco-conjugates). The presence of modified sugar moiety on a glycoprotein makes it possible to link bioactive molecules via modified glycan chains, thereby assisting in the assembly of bionanoparticles that are useful for developing the targeted drug delivery system and contrast agents for magnetic resonance imaging. The reengineered recombinant glycosyltransferases also make it possible to (1) remodel the oligosaccharide chains of glycoprotein drugs, and (2) synthesize oligosaccharides for vaccine development. JF - AAPS Journal AU - Qasba, Pradman K AU - Ramakrishnan, Boopathy AU - Boeggeman, Elizabeth AD - Basic Research Program, SAIC-Frederick Inc, Frederick, MD, qasba@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - E190 EP - E195 PB - American Association of Pharmaceutical Scientists VL - 8 IS - 1 SN - 1550-7416, 1550-7416 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Sugar KW - oligosaccharides KW - Magnetic resonance imaging KW - Enzymes KW - Drug development KW - Polysaccharides KW - Glycosyltransferase KW - Glycolipids KW - Proteoglycans KW - Contrast media KW - Vaccines KW - Glycoproteins KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21152271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Mutant+glycosyltransferases+assist+in+the+development+of+a+targeted+drug+delivery+system+and+contrast+agents+for+MRI&rft.au=Qasba%2C+Pradman+K%3BRamakrishnan%2C+Boopathy%3BBoeggeman%2C+Elizabeth&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2006-03-01&rft.volume=8&rft.issue=1&rft.spage=E190&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Faapsj080123 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sugar; Drug delivery; oligosaccharides; Magnetic resonance imaging; Enzymes; Drug development; Polysaccharides; Glycosyltransferase; Proteoglycans; Glycolipids; Contrast media; Glycoproteins; Vaccines DO - http://dx.doi.org/10.1208/aapsj080123 ER - TY - JOUR T1 - A new method of wet scanning electron microscopy for the analysis of myelination in EAE mouse model of multiple sclerosis AN - 21047930; 6676083 AB - Development of effective therapies for multiple sclerosis (MS) is dependent on the advancement of improved tools for evaluation of progression of this disease in animal models. We present a novel technique utilizing scanning electron microscopy (SEM) for imaging wet biological specimens thus enabling rapid and high-resolution imaging of myelin in mouse spinal cord (SC). We demonstrate the advantages of using the wet SEM technique to image myelin in a murine model of MS, experimental autoimmune encephalomyelitis (EAE) induced in the Biozzi (antibody-high) mouse, by sensitization with spinal cord homogenate (SCH) in adjuvant. Our studies show that the methodology allows easy identification of normal and pathological components with great clarity, which is then correlated with light microscopy (LM) and validated thereby. Furthermore, we demonstrate gold immunolabeling of specific epitopes. We conclude that the new technique provides a quick, accurate, and detailed structural evaluation of the SC that can be applied to advance the research of MS. JF - Experimental and Toxicologic Pathology AU - Nyska, Abraham AU - Horowitz, Miri AU - Anaby, Debbie AU - Sabban, Alon AU - Leizerman, Ilit AU - Blaugrund, Eran AU - Mayk, Adi AU - Behar, Vered AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, NC, USA, anyska@bezeqint.net Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 291 EP - 297 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 57 IS - 4 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Wet scanning electron microscopy KW - Myelin KW - Multiple sclerosis KW - Scanning electron microscopy KW - Spinal cord KW - Animal models KW - Gold KW - Adjuvants KW - Experimental allergic encephalomyelitis KW - Myelination KW - imaging KW - Epitopes KW - N3 11021:Neuroimaging techniques KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21047930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=A+new+method+of+wet+scanning+electron+microscopy+for+the+analysis+of+myelination+in+EAE+mouse+model+of+multiple+sclerosis&rft.au=Nyska%2C+Abraham%3BHorowitz%2C+Miri%3BAnaby%2C+Debbie%3BSabban%2C+Alon%3BLeizerman%2C+Ilit%3BBlaugrund%2C+Eran%3BMayk%2C+Adi%3BBehar%2C+Vered&rft.aulast=Nyska&rft.aufirst=Abraham&rft.date=2006-03-01&rft.volume=57&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2005.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Scanning electron microscopy; Spinal cord; Multiple sclerosis; Animal models; Gold; Adjuvants; Myelination; Experimental allergic encephalomyelitis; imaging; Epitopes DO - http://dx.doi.org/10.1016/j.etp.2005.11.001 ER - TY - JOUR T1 - Interaction of Zwitterionic Penicillins with the OmpF Channel Facilitates Their Translocation AN - 20987494; 7453451 AB - To study translocation of beta -lactam antibiotics of different size and charge across the outer bacterial membrane, we combine an analysis of ion currents through single trimeric outer membrane protein F (OmpF) porins in planar lipid bilayers with molecular dynamics simulations. Because the size of penicillin molecules is close to the size of the narrowest part of the OmpF pore, penicillins occlude the pore during their translocation. Favorably interacting penicillins cause time-resolvable transient blockages of the small-ion current through the channel and thereby provide information about their dynamics within the pore. Analyzing these random fluctuations, we find that ampicillin and amoxicillin have a relatively high affinity for OmpF. In contrast, no or only a weak interaction is detected for carbenicillin, azlocillin, and piperacillin. Molecular dynamics simulations suggest a possible pathway of these drugs through the OmpF channel and rationalize our experimental findings. For zwitterionic ampicillin and amoxicillin, we identify a region of binding sites near the narrowest part of the channel pore. Interactions with these sites partially compensate for the entropic cost of drug confinement by the channel. Whereas azlocillin and piperacillin are clearly too big to pass through the channel constriction, dianionic carbenicillin does not find an efficient binding region in the constriction zone. Carbenicillin's favorable interactions are limited to the extracellular vestibule. These observations confirm our earlier suggestion that a set of high-affinity sites at the narrowest part of the OmpF channel improves a drug's ability to cross the membrane via the pore. JF - Biophysical Journal AU - Danelon, Christophe AU - Nestorovich, Ekaterina M AU - Winterhalter, Mathias AU - Ceccarelli, Matteo AU - Bezrukov, Sergey M AD - Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, bezrukos@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1617 EP - 1627 PB - Biophysical Society, [mailto:ckenney@biophysics.org], [URL:http://www.biophysics.org/] VL - 90 IS - 5 SN - 0006-3495, 0006-3495 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - Lipid bilayers KW - Amoxicillin KW - outer membrane proteins KW - Channel pores KW - Porins KW - Ion currents KW - Ampicillin KW - Carbenicillin KW - Penicillin KW - Azlocillin KW - beta -Lactam antibiotics KW - Piperacillin KW - Drugs KW - Translocation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=Interaction+of+Zwitterionic+Penicillins+with+the+OmpF+Channel+Facilitates+Their+Translocation&rft.au=Danelon%2C+Christophe%3BNestorovich%2C+Ekaterina+M%3BWinterhalter%2C+Mathias%3BCeccarelli%2C+Matteo%3BBezrukov%2C+Sergey+M&rft.aulast=Danelon&rft.aufirst=Christophe&rft.date=2006-03-01&rft.volume=90&rft.issue=5&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Biophysical+Journal&rft.issn=00063495&rft_id=info:doi/10.1529%2Fbiophysj.105.075192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein transport; Amoxicillin; Lipid bilayers; outer membrane proteins; Channel pores; Porins; Ampicillin; Ion currents; Carbenicillin; Penicillin; Azlocillin; beta -Lactam antibiotics; Piperacillin; Translocation; Drugs DO - http://dx.doi.org/10.1529/biophysj.105.075192 ER - TY - JOUR T1 - A Factorial Trial Including Garlic Supplements Assesses Effect in Reducing Precancerous Gastric Lesions AN - 20871745; 6714680 AB - The Shandong Intervention Trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in Linqu County, Shandong Province, China, a region with high gastric cancer mortality rates and a prevalence in adults of Helicobacter pylori of similar to 67%. The 3 interventions were one-time treatment with amoxicillin and omeprazole for Helicobacter pylori infection, and long-term administration of a garlic supplement (aged garlic extract and steam-distilled garlic oil) and a vitamin supplement (vitamins E and C and selenium). This paper describes the design and initial findings on treatment compliance, completeness of follow-up data, and eradication of Helicobacter pylori. JF - Journal of Nutrition AU - Gail, Mitchell H AU - You, Wei-Cheng AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 and Beijing Institute of Cancer Research, Haidian District, Beijing, China 100036 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 813S EP - 815S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 3 SN - 0022-3166, 0022-3166 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Mortality KW - Amoxicillin KW - Data processing KW - Allium sativum KW - Infection KW - Oil KW - Selenium KW - Vitamin E KW - Dietary supplements KW - Vitamins KW - Gastric cancer KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20871745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=A+Factorial+Trial+Including+Garlic+Supplements+Assesses+Effect+in+Reducing+Precancerous+Gastric+Lesions&rft.au=Gail%2C+Mitchell+H%3BYou%2C+Wei-Cheng&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2006-03-01&rft.volume=136&rft.issue=3&rft.spage=813S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Oil; Selenium; Mortality; Amoxicillin; Vitamin E; Data processing; Vitamins; Dietary supplements; Infection; Gastric cancer; Helicobacter pylori; Allium sativum ER - TY - JOUR T1 - Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping AN - 20857786; 8368065 AB - There has been growing interest in using manganese-enhanced MRI (MEMRI) to detect neuronal activation, neural architecture, and neuronal connections. Usually Mn2+ produces a very wide range of T1 change. In particular, in neuronal tract tracing experiments the site of Mn2+ injection can have very short T1 while distant regions have small T1 reductions, primarily due to dilution of Mn2+. Most MEMRI studies use T1-weighted sequences, which can only give optimal contrast for a narrow range of T1 changes. To improve sensitivity to the full extent of Mn2+ concentrations and to optimize detection of low concentrations of Mn2+, a fast T1 mapping sequence based on the Look and Locker technique was implemented. Phantom studies demonstrated less than 6.5% error in T1 compared to more conventional T1 measurements. Using center-out segmented EPI, whole-brain 3D T1 maps with 200-m isotropic resolution were obtained in 2 h from rat brain. Mn2+ transport from the rat olfactory bulb through appropriate brain structures could be detected to the amygdala in individual animals. The method reliably detected less than 7% reductions in T1. With this quantitative imaging it should be possible to study more extensive pathways using MEMRI and decrease the dose of Mn2+ used. JF - Magnetic Resonance in Medicine AU - Chuang, Kai-Hsiang AU - Koretsky, Alan AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA, KoretskyA@ninds.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 604 EP - 611 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Neuroimaging KW - Magnetic resonance imaging KW - Brain KW - Olfactory bulb KW - Amygdala KW - N.M.R. KW - Manganese KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Improved+neuronal+tract+tracing+using+manganese+enhanced+magnetic+resonance+imaging+with+fast+T1+mapping&rft.au=Chuang%2C+Kai-Hsiang%3BKoretsky%2C+Alan&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2006-03-01&rft.volume=55&rft.issue=3&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Brain; Neuroimaging; N.M.R.; Amygdala; Brain mapping; Manganese; Olfactory bulb DO - http://dx.doi.org/10.1002/mrm.20797 ER - TY - JOUR T1 - Noninvasive measurement of myocardial tissue volume change during systolic contraction and diastolic relaxation in the canine left ventricle AN - 20855098; 8368050 AB - In coronary circulation the flow in epicardial arteries and veins is observed to be pulsatile and out of phase with each other. Theoretical considerations predict that this phenomenon extends to all levels of the vascular tree and leads to a cyclic fluctuation of regional tissue volume. Intramyocardial tissue volume change between end-systole and end-diastole was measured noninvasively with MRI in 10 closed-chest beagles. The displacement encoding with stimulated-echo technique was used to obtain pixel-by-pixel tissue displacement field between end-diastole and end-systole and vice versa in the midlevel left ventricle, from which the 3D strain matrix and volume changes were calculated. The volume change was between 0.8 - 0.5% (mean - STD) in the epicardial layer and 1.5 - 0.6% in the subendocardial layer of the left ventricle. Tissue volume fluctuation reflects the amount of arterial inflow in a heartbeat under the assumption that regional arterial inflow and venous outflow have little time overlap. The corresponding perfusion level was estimated to be from (1.0 - 0.6) ml/min/g in the epicardial layer to (1.7 - 0.6) ml/min/g in the subendocardial layer, in good agreement with microsphere measurements in the same dog model. The result supports the notion of high arterial resistance at the microvascular level from intramyocardial pressure during systole. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Rodriguez, Ignacio AU - Ennis, Daniel B AU - Wen, Han AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, wenh@nhlbi.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 484 EP - 490 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Microvasculature KW - Perfusion KW - Arteries KW - Magnetic resonance imaging KW - Models KW - Ventricle KW - Veins KW - microspheres KW - N.M.R. KW - Pressure KW - Vascular system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Noninvasive+measurement+of+myocardial+tissue+volume+change+during+systolic+contraction+and+diastolic+relaxation+in+the+canine+left+ventricle&rft.au=Rodriguez%2C+Ignacio%3BEnnis%2C+Daniel+B%3BWen%2C+Han&rft.aulast=Rodriguez&rft.aufirst=Ignacio&rft.date=2006-03-01&rft.volume=55&rft.issue=3&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ventricle; Models; N.M.R.; Veins; Heart; Pressure; Vascular system; Arteries; Perfusion; Magnetic resonance imaging; Microvasculature; microspheres DO - http://dx.doi.org/10.1002/mrm.20786 ER - TY - JOUR T1 - Evaluation of human fetal bone implants in SCID mice as a model of prostate cancer bone metastasis AN - 20633677; 9360755 AB - The metastasis of prostate cancer cells to the bone marrow constitutes the major source of morbidity and mortality in prostate cancer. Studying this process has been hampered by the lack of preclinical models to evaluate novel therapeutics and to study the biology of the disease. One proposed model utilizes human fetal bone implants to serve as the target for prostate cancer cells injected via the tail vein. We employed this model to test the ability of zoledronic acid to prophylax and to treat bone metastases. To improve the rate of bone metastasis, we used two bone implants instead of one to evaluate the cell lines PC3 and PC3M, a more metastatic subline. For this purpose we generated the novel cell line PC3EGFPLuc, which can be used for luminescence and/or fluorescence imaging in vivo. We did not observe bone implant metastases in 52 mice, with 90 bone implants following tail vein injection of 1x106 PC3 or PC3M cells. Soft tissue lesions in the buttocks and hind limbs as well as cellular growth in the hindlimbs were observed via bioluminescence imaging. This evidence together with literature findings suggests that this model produces artifactual 'bone metastasis' lesions. JF - Oncology Reports AU - Singh, A S AU - MacPherson, G R AU - Price, D K AU - Schimel, D AU - Figg, W D AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 519 EP - 524 VL - 15 IS - 3 SN - 1021-335X, 1021-335X KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Mortality KW - Bone cancer KW - Zoledronic acid KW - Fluorescence KW - Bioluminescence KW - Animal models KW - Bone marrow KW - imaging KW - Morbidity KW - Fetuses KW - Metastases KW - Veins KW - Prostate cancer KW - Limbs KW - Bone implants KW - Luminescence KW - Soft tissues KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20633677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=Evaluation+of+human+fetal+bone+implants+in+SCID+mice+as+a+model+of+prostate+cancer+bone+metastasis&rft.au=Singh%2C+A+S%3BMacPherson%2C+G+R%3BPrice%2C+D+K%3BSchimel%2C+D%3BFigg%2C+W+D&rft.aulast=Singh&rft.aufirst=A&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Oncology+Reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bone cancer; Mortality; Fluorescence; Zoledronic acid; Bioluminescence; Bone marrow; Animal models; imaging; Fetuses; Morbidity; Metastases; Limbs; Prostate cancer; Veins; Bone implants; Soft tissues; Luminescence ER - TY - JOUR T1 - Surviving inside a macrophage: The many ways of Brucella AN - 20630603; 6681099 AB - Bacteria of the genus Brucella are intracellular pathogens capable of survival and replication within macrophages of mammalian hosts. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication. JF - Research in Microbiology AU - Celli, Jean AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT, 59840, USA, jcelli@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 93 EP - 98 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 157 IS - 2 SN - 0923-2508, 0923-2508 KW - Microbiology Abstracts B: Bacteriology KW - Brucella KW - Replication KW - Macrophage KW - Virulence factors KW - Permissivity Abstract + References KW - Macrophages KW - Cell survival KW - virulence factors KW - Reviews KW - Life cycle KW - Pathogens KW - Defense mechanisms KW - Organelles KW - J 02750:Phage-host interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20630603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Microbiology&rft.atitle=Surviving+inside+a+macrophage%3A+The+many+ways+of+Brucella&rft.au=Celli%2C+Jean&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2006-03-01&rft.volume=157&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Research+in+Microbiology&rft.issn=09232508&rft_id=info:doi/10.1016%2Fj.resmic.2005.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Macrophages; virulence factors; Replication; Reviews; Life cycle; Defense mechanisms; Pathogens; Organelles; Brucella DO - http://dx.doi.org/10.1016/j.resmic.2005.10.002 ER - TY - JOUR T1 - Intracellular cytokine optimization and standard operating procedure AN - 20529514; 7635944 AB - We describe here a method for optimizing the use of polychromatic flow cytometry (with up to 17 fluorochromes simultaneously) in surface and intracellular staining of human T lymphocytes. We will highlight and discuss how to procedurally optimize key steps in the experimental process before an intracellular cytokine staining assay protocol is finalized. These include but are not limited to the titration of monoclonal antibodies, use of a dead- cell discriminator and 'dump' channel, selection of a cytokine secretion inhibitor, selection of fixation and permeabilization reagents, and inclusion of compensation controls. Building on this basic protocol, we then establish a polychromatic assay designed to detect five separate functions of T lymphocytes (production of three cytokines and one chemokine, and degranulation) while simultaneously identifying multiple surface markers on the responding cells. JF - Nature Protocols AU - Lamoreaux, Laurie AU - Roederer, Mario AU - Koup, Richard Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1507 EP - 1516 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 1 IS - 3 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cytometry KW - Functional analysis KW - Immunological techniques KW - Flow cytometry KW - Chemokines KW - Monoclonal antibodies KW - Degranulation KW - Titration KW - Lymphocytes T KW - Cytokines KW - fluorochromes KW - Surface markers KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20529514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Intracellular+cytokine+optimization+and+standard+operating+procedure&rft.au=Lamoreaux%2C+Laurie%3BRoederer%2C+Mario%3BKoup%2C+Richard&rft.aulast=Lamoreaux&rft.aufirst=Laurie&rft.date=2006-03-01&rft.volume=1&rft.issue=3&rft.spage=1507&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2006.268 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Chemokines; Monoclonal antibodies; Degranulation; Titration; Lymphocytes T; Cytokines; fluorochromes; Surface markers DO - http://dx.doi.org/10.1038/nprot.2006.268 ER - TY - JOUR T1 - Curcumin is an Inhibitor of p300 Histone Acetylatransferase AN - 20234684; 8011386 AB - Histone acetyltransferases (HATs), and p300/CBP in particular, have been implicated in cancer cell growth and survival, and as such, HATs represent novel, therapeutically relevant molecular targets for drug development. In this study, we demonstrate that the small molecule natural product curcumin, whose medicinal properties have long been recognized in India and Southeast Asia, is a selective HAT inhibitor. Furthermore the data indicate that alpha , beta unsaturated carbonyl groups in the curcumin side chain function as Michael reaction sites and that the Michael reaction acceptor functionality of curcumin is required for its HAT-inhibitory activity. In cells, curcumin promoted proteasome-dependent degradation of p300 and the closely related CBP protein without affecting the HATs PCAF or GCN5. In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate. Radiolabeled curcumin formed a covalent association with p300, and tetrahydrocurcumin displayed no p300 inhibitory activity, consistent with a Michael reaction- dependent mechanism. Finally, curcumin was able to effectively block histone hyperacetylation in both PC3-M prostate cancer cells and peripheral blood lymphocytes induced by the histone deacetylase inhibitor MS-275. These data thus identify the medicinal natural product curcumin as a novel lead compound for development of possibly therapeutic, p300/CBP-specific HAT inhibitors. JF - Medicinal Chemistry AU - Marcu, Monica G AU - Jung, Yun-Jin AU - Lee, Sunmin AU - Chung, Eun-Joo AU - Lee, Min-Jung AU - Trepel, Jane AU - Neckers, Len AD - Urologic Oncology Branch and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 169 EP - 174 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 2 IS - 2 SN - 1573-4064, 1573-4064 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Curcumin KW - p300/CBP KW - acetylation KW - Michael reaction acceptor KW - Cell survival KW - Histone deacetylase KW - Data processing KW - Histone acetyltransferase KW - Peripheral blood KW - Drug development KW - natural products KW - Lymphocytes KW - Prostate cancer KW - CBP protein KW - Histone H3 KW - carbonyls KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicinal+Chemistry&rft.atitle=Curcumin+is+an+Inhibitor+of+p300+Histone+Acetylatransferase&rft.au=Marcu%2C+Monica+G%3BJung%2C+Yun-Jin%3BLee%2C+Sunmin%3BChung%2C+Eun-Joo%3BLee%2C+Min-Jung%3BTrepel%2C+Jane%3BNeckers%2C+Len&rft.aulast=Marcu&rft.aufirst=Monica&rft.date=2006-03-01&rft.volume=2&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Medicinal+Chemistry&rft.issn=15734064&rft_id=info:doi/10.2174%2F157340606776056133 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Histone deacetylase; Curcumin; Data processing; Histone acetyltransferase; natural products; Drug development; Peripheral blood; Lymphocytes; Prostate cancer; CBP protein; Histone H3; carbonyls DO - http://dx.doi.org/10.2174/157340606776056133 ER - TY - JOUR T1 - Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth AN - 20227434; 7332323 AB - Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels greater than or equal to 1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% "viable" (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects. JF - Environmental Pollution AU - De Nicola, Elena AU - Meric, Suereyya AU - Gallo, Marialuisa AU - Iaccarino, Mario AU - Della Rocca, Claudio AU - Lofrano, Giusy AU - Russo, Teresa AU - Pagano, Giovanni AD - Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I- 80131 Naples, Italy, gbpagano@tin.it Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 46 EP - 54 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 146 IS - 1 SN - 0269-7491, 0269-7491 KW - Heart urchins KW - Sand dollars KW - Sea urchins KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Vegetable tannin KW - Synthetic tannin KW - Leather tanning KW - Toxicity KW - Hormesis KW - Algae KW - Echinoderms KW - Vegetables KW - Cell culture KW - Sperm KW - Toxicity tests KW - Bioassay KW - Defects KW - Mimosa KW - Fertilization KW - Pollution indicators KW - Algal culture KW - Larvae KW - Embryonic development KW - Tannins KW - Sphaerechinus granularis KW - Embryogenesis KW - fertilization KW - Bioassays KW - hormesis KW - Water Pollution Effects KW - Progeny KW - Echinoidea KW - Abnormalities KW - Algal Growth KW - Growth KW - Dunaliella tertiolecta KW - Tannic acid KW - Pollution KW - Aquaculture techniques KW - offspring KW - Paracentrotus lividus KW - Marine KW - tannic acid KW - mimosa KW - Bioaccumulation KW - Cultures KW - Marine aquaculture KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24370:Natural Toxins KW - Q5 08504:Effects on organisms KW - AQ 00008:Effects of Pollution KW - SW 3030:Effects of pollution KW - K 03320:Cell Biology KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution&rft.atitle=Vegetable+and+synthetic+tannins+induce+hormesis%2Ftoxicity+in+sea+urchin+early+development+and+in+algal+growth&rft.au=De+Nicola%2C+Elena%3BMeric%2C+Suereyya%3BGallo%2C+Marialuisa%3BIaccarino%2C+Mario%3BDella+Rocca%2C+Claudio%3BLofrano%2C+Giusy%3BRusso%2C+Teresa%3BPagano%2C+Giovanni&rft.aulast=De+Nicola&rft.aufirst=Elena&rft.date=2006-03-01&rft.volume=146&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution&rft.issn=02697491&rft_id=info:doi/10.1016%2Fj.envpol.2006.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Algal culture; Growth; Bioassays; Bioaccumulation; Embryonic development; Marine aquaculture; Toxicity; Pollution indicators; Toxicity tests; Abnormalities; Aquaculture techniques; Defects; Embryogenesis; Fertilization; Vegetables; hormesis; Cell culture; Progeny; Sperm; Tannic acid; Pollution; Algae; fertilization; tannic acid; Larvae; offspring; Echinoderms; Water Pollution Effects; Cultures; Tannins; Algal Growth; Bioassay; Paracentrotus lividus; Mimosa; Dunaliella tertiolecta; mimosa; Echinoidea; Sphaerechinus granularis; Marine DO - http://dx.doi.org/10.1016/j.envpol.2006.06.018 ER - TY - JOUR T1 - Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen AN - 20221802; 6719606 AB - We have analyzed the level of gene coregulation, using gene expression patterns measured across the National Cancer Institute's 60 tumor cell panels (NCI sub(6) sub(0)), in the context of predefined pathways or functional categories annotated by KEGG (Kyoto Encyclopedia of Genes and Genomes), BioCarta, and GO (Gene Ontology). Statistical methods were used to evaluate the level of gene expression coherence (coordinated expression) by comparing intra- and interpathway gene-gene correlations. Our results show that gene expression in pathways, or groups of functionally related genes, has a significantly higher level of coherence than that of a randomly selected set of genes. Transcriptional-level gene regulation appears to be on a ''need to be'' basis, such that pathways comprising genes encoding closely interacting proteins and pathways responsible for vital cellular processes or processes that are related to growth or proliferation, specifically in cancer cells, such as those engaged in genetic information processing, cell cycle, energy metabolism, and nucleotide metabolism, tend to be more modular (lower degree of gene sharing) and to have genes significantly more coherently expressed than most signaling and regular metabolic pathways. Hierarchical clustering of pathways based on their differential gene expression in the NCI sub(6) sub(0) further revealed interesting interpathway communications or interactions indicative of a higher level of pathway regulation. The knowledge of the nature of gene expression regulation and biological pathways can be applied to understanding the mechanism by which small drug molecules interfere with biological systems. JF - Genomics AU - Huang, R AU - Wallqvist, A AU - Covell, D G AD - Developmental Therapeutics Program, Screening Technologies Branch, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA, covell@ncifcrf.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 315 EP - 328 PB - Elsevier Inc. VL - 87 IS - 3 SN - 0888-7543, 0888-7543 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Statistics KW - Energy metabolism KW - Cell cycle KW - Communication KW - Transcription KW - double prime GO gene KW - Tumor cells KW - Nucleotides KW - Cancer KW - Gene expression KW - Information processing KW - Gene regulation KW - Metabolic pathways KW - Cell proliferation KW - Drugs KW - Signal transduction KW - W 30940:Products KW - G 07470:Cytogenetics & general UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20221802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Comprehensive+analysis+of+pathway+or+functionally+related+gene+expression+in+the+National+Cancer+Institute%27s+anticancer+screen&rft.au=Huang%2C+R%3BWallqvist%2C+A%3BCovell%2C+D+G&rft.aulast=Huang&rft.aufirst=R&rft.date=2006-03-01&rft.volume=87&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2005.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Statistics; Energy metabolism; Cell cycle; Communication; Transcription; double prime GO gene; Tumor cells; Cancer; Nucleotides; Gene expression; Gene regulation; Information processing; Metabolic pathways; Cell proliferation; Drugs; Signal transduction DO - http://dx.doi.org/10.1016/j.ygeno.2005.11.011 ER - TY - JOUR T1 - Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay AN - 20220726; 6685596 AB - Monolayers of Hep G2/C3A cells were inoculated with genotype 1 Hepatitis E virus (HEV) mixed with either anti-HEV or an appropriate control. After 5 or 6 days, cell monolayers were stained with anti-HEV and infected cells were identified by immunofluorescence microscopy and counted. Anti-HEV from vaccinated or infected rhesus monkeys neutralized the virus, as did mAbs that recognized epitopes on the C terminus of a recombinant vaccine protein. Antibodies were broadly cross-reactive, since convalescent serum from animals infected with any one of the four mammalian genotypes all neutralized the genotype 1 virus. JF - Journal of General Virology AU - Emerson, Suzanne U AU - Clemente-Casares, Pilar AU - Moiduddin, Nasser AU - Arankalle, Vidya A AU - Torian, Udana AU - Purcell, Robert H AD - Molecular Hepatitis and Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC-8009, Bethesda, MD 20892-8009, USA, semerson@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 697 EP - 704 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 87 IS - 3 SN - 0022-1317, 0022-1317 KW - Rhesus monkey KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Monoclonal antibodies KW - Hepatitis E virus KW - Cell culture KW - Genotypes KW - Immunofluorescence KW - Vaccination KW - Antibodies KW - Microscopy KW - Macaca mulatta KW - Vaccines KW - Neutralization KW - Epitopes KW - W 30915:Pharmaceuticals & Vaccines KW - V 22092:Viral antigenic properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20220726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Virology&rft.atitle=Putative+neutralization+epitopes+and+broad+cross-genotype+neutralization+of+Hepatitis+E+virus+confirmed+by+a+quantitative+cell-culture+assay&rft.au=Emerson%2C+Suzanne+U%3BClemente-Casares%2C+Pilar%3BMoiduddin%2C+Nasser%3BArankalle%2C+Vidya+A%3BTorian%2C+Udana%3BPurcell%2C+Robert+H&rft.aulast=Emerson&rft.aufirst=Suzanne&rft.date=2006-03-01&rft.volume=87&rft.issue=3&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Virology&rft.issn=00221317&rft_id=info:doi/10.1099%2Fvir.0.81545-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; Monoclonal antibodies; Microscopy; Cell culture; Immunofluorescence; Vaccines; Genotypes; Vaccination; Neutralization; Epitopes; Macaca mulatta; Hepatitis E virus DO - http://dx.doi.org/10.1099/vir.0.81545-0 ER - TY - JOUR T1 - Characterization of a New NIH-Registered Variant Human Embryonic Stem Cell Line, BG01V: A Tool for Human Embryonic Stem Cell Research AN - 20204731; 6752836 AB - Human embryonic stem cells (hESCs) offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Characterizing these cells provides important information about their current state and affords relevant details for subsequent manipulations. For example, identifying genes expressed during culture, as well as their temporal expression order after passaging and conditions influencing the formation of all three germ layers may be helpful for the production of functional beta islet cells used in treating type I diabetes. Although several hESC lines have demonstrated karyotypic instability during extended time in culture, select variant lines exhibit characteristics similar to their normal parental lines. Such variant lines may be excellent tools and abundant sources of cells for pilot studies and in vitro differentiation research in which chromosome number is not a concern, similar to the role currently played by embryonal carcinoma cell lines. It is crucial that the cells be surveyed at a genetic and proteomic level during extensive propagation, expansion, and manipulation in vitro. Here we describe a comprehensive characterization of the variant hESC line BG01V, which was derived from the karyotypically normal, parental hESC line BG01. Our characterization process employs cytogenetic analysis, short tandem repeat and HLA typing, mitochondrial DNA sequencing, gene expression analysis using quantitative reverse transcription-polymerase chain reaction and microarray, assessment of telomerase activity, methylation analysis, and immunophenotyping and teratoma formation, in addition to screening for bacterial, fungal, mycoplasma, and human pathogen contamination. JF - Stem Cells AU - Plaia, Todd W AU - Josephson, Richard AU - Liu, Ying AU - Zeng, Xianmin AU - Ording, Carol AU - Toumadje, Arazdordi AU - Brimble, Sandii N AU - Sherrer, Eric S AU - Uhl, Elizabeth W AU - Freed, William J AU - Schulz, Thomas C AU - Maitra, Anirban AU - Rao, Mahendra S AU - Auerbach, Jonathan M AD - Stem Cell Center, American Type Culture Collection, Manassas, Virginia, USA. Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Cellular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. BresaGen, Inc., Athens, Georgia, USA. Department of Veterinary Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, USA. Department of Pathology, Oncology, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 531 EP - 546 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - Short tandem repeats KW - Contamination KW - Telomerase KW - Tissue typing KW - Chromosome number KW - Islet cells KW - Cell culture KW - Pathogens KW - DNA microarrays KW - Diabetes mellitus KW - Differentiation KW - Tumor cell lines KW - Mitochondrial DNA KW - Stem cells KW - Embryo cells KW - teratoma KW - DNA methylation KW - proteomics KW - Mycoplasma KW - J 02310:Genetics & Taxonomy KW - W 30905:Medical Applications KW - G 07770:Bacteria KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20204731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Characterization+of+a+New+NIH-Registered+Variant+Human+Embryonic+Stem+Cell+Line%2C+BG01V%3A+A+Tool+for+Human+Embryonic+Stem+Cell+Research&rft.au=Plaia%2C+Todd+W%3BJosephson%2C+Richard%3BLiu%2C+Ying%3BZeng%2C+Xianmin%3BOrding%2C+Carol%3BToumadje%2C+Arazdordi%3BBrimble%2C+Sandii+N%3BSherrer%2C+Eric+S%3BUhl%2C+Elizabeth+W%3BFreed%2C+William+J%3BSchulz%2C+Thomas+C%3BMaitra%2C+Anirban%3BRao%2C+Mahendra+S%3BAuerbach%2C+Jonathan+M&rft.aulast=Plaia&rft.aufirst=Todd&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Short tandem repeats; Contamination; Telomerase; Tissue typing; Chromosome number; Cell culture; Islet cells; Pathogens; DNA microarrays; Diabetes mellitus; Differentiation; Stem cells; Mitochondrial DNA; Tumor cell lines; teratoma; Embryo cells; DNA methylation; proteomics; Mycoplasma ER - TY - JOUR T1 - [beta]-Adrenergic Receptor Polymorphisms and Response to Salmeterol AN - 199623443; 16322642 AB - Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists. We investigated whether such genotype-specific effects occur when patients are treated with long-acting beta-agonists and whether such effects are modified by concurrent inhaled corticosteroid (ICS) use. We compared salmeterol response in patients with asthma homozygous for arginine at B16 (B16Arg/Arg) with those homozygous for glycine at B16 (B16Gly/Gly) in two separate cohorts. In the first, subjects were randomized to regular therapy with salmeterol while simultaneously discontinuing ICS therapy. In the second, subjects were randomized to regular therapy with salmeterol while continuing concomitant ICS. In both trials, B16Arg/Arg subjects did not benefit compared with B16Gly/Gly subjects after salmeterol was initiated. In the first cohort, compared with placebo, the addition of salmeterol was associated with a 51.4 L/min lower A.M. peak expiratory flow (PEF; p = 0.005) in B16Arg/Arg subjects(salmeterol, n = 12; placebo, n = 5) as compared with B16Gly/Gly subjects (salmeterol, n = 13; placebo, n = 13). In the second cohort, B16Arg/Arg subjects treated with salmeterol and ICS concurrently (n = 8) had a lower A.M. PEF (36.8 L/min difference, p = 0.048) than B16Gly/Gly subjects (n = 22) treated with the same regimen. In addition, B16 Arg/Arg subjects in the second cohort had lower FEV1 (0.42 L, p = 0.003), increased symptom scores (0.2 units, p = 0.034), and increased albuterol rescue use (0.95 puffs/d, p = 0.004) compared with B16Gly/Gly subjects. Relative to B16Gly/Gly patients with asthma, B16Arg/Arg patients with asthma may have an impaired therapeutic response to salmeterol in either the absence or presence of concurrent ICS use. Investigation of alternate treatment strategies may benefit this group. JF - American Journal of Respiratory and Critical Care Medicine AU - Wechsler, Michael E AU - Lehman, Erik AU - Lazarus, Stephen C AU - Lemanske, Robert F, Jr AU - et al Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 519 EP - 26 CY - New York PB - American Thoracic Society VL - 173 IS - 5 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Adrenergic beta-Agonists KW - Glucocorticoids KW - Receptors, Adrenergic, beta KW - Triamcinolone KW - salmeterol KW - Albuterol KW - Genotype KW - Drug Therapy, Combination KW - Albuterol -- therapeutic use KW - Triamcinolone -- administration & dosage KW - Humans KW - Glucocorticoids -- administration & dosage KW - Adult KW - Administration, Inhalation KW - Male KW - Female KW - Asthma -- drug therapy KW - Receptors, Adrenergic, beta -- genetics KW - Albuterol -- analogs & derivatives KW - Polymorphism, Genetic KW - Asthma -- genetics KW - Adrenergic beta-Agonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199623443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=%5Bbeta%5D-Adrenergic+Receptor+Polymorphisms+and+Response+to+Salmeterol&rft.au=Wechsler%2C+Michael+E%3BLehman%2C+Erik%3BLazarus%2C+Stephen+C%3BLemanske%2C+Robert+F%2C+Jr%3Bet+al&rft.aulast=Wechsler&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=173&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Mar 1, 2006 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans AN - 19954424; 6787158 AB - The observation that Toll-like receptor (TLR)2-deficient mice are highly susceptible to mycobacteria suggests that mutations altering TLR2 expression may impair host response to Mycobacterium tuberculosis. We evaluated the association between guanine-thymine (GT) repeat polymorphism in intron II of the TLR2 gene and the presence of tuberculosis (TB) in Koreans. The numbers of GT repeats were determined by PCR and gene scans for 176 TB patients and 196 controls. The recombinant TLR2 promoter/exonl/exonll/intronll/luciferase constructs including three representative repeats: (GT) sub(13), (GT) sub(20), and (GT) sub(24) were transfected into K562 cells, and iuciferase activities were estimated and compared. The expression of TLR2 on CD14 + peripheral blood mononuclear cells (PBMC) from healthy volunteers were measured with flow cytometry. Genotypes with shorter GT repeats were more common among TB patients (49.4 vs37.7%, P=0.02). This observation was confirmed among 82 other TB patients as a validation cohort. Shorter GT repeats were associated with weaker promoter activities and lower TLR2 expression on CD14+ PBMCs. In conclusion, the development of TB disease in Koreans was associated with shorter GT repeats in intron II of the TLR2 gene. This association is correlated with lower expression of TLR2 through weaker promoter activity for genes with shorter GT repeats. JF - Genes and Immunity AU - Yim, J-J AU - Lee, H W AU - Lee, H S AU - Kim, Y W AU - Han, S K AU - Shim, Y-S AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, CRC B3-4141, 10 Center Drive, MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 150 EP - 155 VL - 7 IS - 2 SN - 1466-4879, 1466-4879 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Gene polymorphism KW - TLR2 protein KW - Microsatellites KW - CD14 antigen KW - Flow cytometry KW - Promoters KW - Peripheral blood mononuclear cells KW - Introns KW - Polymerase chain reaction KW - Tuberculosis KW - Korea, Rep. KW - Mutation KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - G 07240:Immunogenetics KW - J 02350:Immunology KW - F 06414:Other genes (e.g. cytokine genes) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19954424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+and+Immunity&rft.atitle=The+association+between+microsatellite+polymorphisms+in+intron+II+of+the+human+Toll-like+receptor+2+gene+and+tuberculosis+among+Koreans&rft.au=Yim%2C+J-J%3BLee%2C+H+W%3BLee%2C+H+S%3BKim%2C+Y+W%3BHan%2C+S+K%3BShim%2C+Y-S%3BHolland%2C+S+M&rft.aulast=Yim&rft.aufirst=J-J&rft.date=2006-03-01&rft.volume=7&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Genes+and+Immunity&rft.issn=14664879&rft_id=info:doi/10.1038%2Fsj.gene.6364274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Promoters; Peripheral blood mononuclear cells; Gene polymorphism; TLR2 protein; Microsatellites; Introns; Polymerase chain reaction; Tuberculosis; CD14 antigen; Mutation; Toll-like receptors; Mycobacterium tuberculosis; Korea, Rep. DO - http://dx.doi.org/10.1038/sj.gene.6364274 ER - TY - JOUR T1 - Synthesis of hypermodified adenosine derivatives as selective adenosine A sub(3) receptor ligands AN - 19950299; 6659438 AB - We investigated the A sub(3)AR affinity and selectivity of a series of 2- substituted 3'-azido and 3'-amino adenosine derivatives as well as some 5'- uronamide derivatives thereof. All compounds showed high A sub(3)AR selectivity. While the 3'-azides appeared to be A sub(3)AR antagonists with moderate A sub(3)AR affinity, their 3'-amino congeners exhibit significantly improved A sub(3)AR affinity and behave as partial agonists. For both the 3'-azides and the 3'- amines, the 5'-methylcarbamoyl modification improved the overall affinity. Introduction of a 2-phenylethynyl substituent provided high affinity for the A sub(3)AR. JF - Bioorganic and Medicinal Chemistry AU - Cosyn, Liesbet AU - Gao, Zhan-Guo AU - Van Rompaey, Philippe AU - Lu, Changrui AU - Jacobson, Kenneth A AU - Van Calenbergh, Serge AD - Laboratory for Medicinal Chemistry (FFW), UGent, Harelbekestraat 72, B-9000, Belgium, kajacobs@helix.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 1403 EP - 1412 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 5 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Adenosine A sub(3) receptor KW - Selectivity KW - Affinity KW - Ribose and purine modifications KW - amines KW - Adenosine A3 receptors KW - Congeners KW - Adenosine KW - Antagonists KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19950299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+of+hypermodified+adenosine+derivatives+as+selective+adenosine+A+sub%283%29+receptor+ligands&rft.au=Cosyn%2C+Liesbet%3BGao%2C+Zhan-Guo%3BVan+Rompaey%2C+Philippe%3BLu%2C+Changrui%3BJacobson%2C+Kenneth+A%3BVan+Calenbergh%2C+Serge&rft.aulast=Cosyn&rft.aufirst=Liesbet&rft.date=2006-03-01&rft.volume=14&rft.issue=5&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2005.09.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Adenosine A3 receptors; amines; Congeners; Adenosine; Antagonists DO - http://dx.doi.org/10.1016/j.bmc.2005.09.062 ER - TY - JOUR T1 - The Newborn Drug Development Initiative AN - 19901528; 6715433 AB - The Best Pharmaceuticals for Children Act (BPCA; Pub L 107-109) was enacted in January 2002 and will sunset in October 2007. The BPCA established processes for studying off-patent and on-patent drugs that are used in pediatric population. Although some drugs have been successfully developed for the neonate (eg, surfactant, nitric oxide), drug development for the youngest, least mature, and most vulnerable pediatric patients is generally lacking. Most drugs are empirically administered to newborns once efficacy has been demonstrated in adults and usefulness is suspected or demonstrated in the older pediatric population. Unfortunately, this process undermines the ability to perform the appropriate studies necessary to demonstrate a drug's short- and long-term safety and efficacy and establish appropriate dosing in neonates. The Newborn Drug Development Initiative Workshop I (held March 29-30, 2004) specifically addressed scientific, clinical, and ethical concerns in the development of trials of pediatric therapeutic agents for neonates. Implementation of the BPCA for all pediatric populations will foster collaboration among federal agencies and academic institutions on scientific investigation, clinical-study design, and consideration of the weight of evidence and address ethical issues related to the performance of drug studies. JF - Pediatrics AU - Giacoia, George P AU - Birenbaum, Debra L AU - Sachs, Hari Cheryl AU - Mattison, Donald R AD - Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Division of Pediatric Drug Development, Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - S1 EP - S8 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 3 SN - 0031-4005, 0031-4005 KW - Biotechnology and Bioengineering Abstracts KW - Conferences KW - Pediatrics KW - Ethics KW - Pharmaceuticals KW - Drug development KW - Nitric oxide KW - Neonates KW - Children KW - Drugs KW - Clinical trials KW - Surfactants KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19901528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=The+Newborn+Drug+Development+Initiative&rft.au=Giacoia%2C+George+P%3BBirenbaum%2C+Debra+L%3BSachs%2C+Hari+Cheryl%3BMattison%2C+Donald+R&rft.aulast=Giacoia&rft.aufirst=George&rft.date=2006-03-01&rft.volume=117&rft.issue=3&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Conferences; Pediatrics; Ethics; Pharmaceuticals; Nitric oxide; Drug development; Neonates; Children; Surfactants; Clinical trials; Drugs ER - TY - JOUR T1 - Natural Products from Marine Invertebrates and Microbes as Modulators of Antitumor Targets AN - 19895300; 7643279 AB - Over the last twenty-five to thirty years, exploration of the marine fauna and microbial flora has progressed from a random search by natural product chemists who liked to dive and wished to combine their hobby with their profession, to fully integrated programs of systemic investigation of the chemical agents elaborated by marine organisms of all phyla (as presumably defensive agents against predators) for their potential as leads to human-use drug candidates where the putative mechanisms have been identified as modulation of, and/or interaction with, potential molecular targets, rather than just exhibiting general cytotoxicity. This review is not exhaustive but is meant to cover the highlights of such agents and is arranged on a (nominal) target basis rather than by organism or chemical class. JF - Current Drug Targets AU - Newman, D J AU - Cragg, G M AD - Natural Products Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD, 21702, USA. Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 279 EP - 304 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 3 SN - 1389-4501, 1389-4501 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts KW - Marine natural products KW - molecular targets KW - cancer KW - structural modification KW - Cytotoxicity KW - Marine fauna KW - Reviews KW - Invertebrata KW - Marine organisms KW - natural products KW - Predators KW - Drug development KW - Antitumor agents KW - Q4 27740:Products KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=The+psychology+of+the+crowd&rft.au=Katz%2C+Daniel&rft.aulast=Katz&rft.aufirst=Daniel&rft.date=1950-01-01&rft.volume=&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=Fields+of+psychology%3A+Basic+and+applied+%282nd+ed.%2C+3rd+printing%29&rft.title=Fields+of+psychology%3A+Basic+and+applied+%282nd+ed.%2C+3rd+printing%29&rft.issn=&rft_id=info:doi/10.1037%2F11550-007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Marine fauna; Reviews; Marine organisms; Drug development; Predators; natural products; Antitumor agents; Invertebrata DO - http://dx.doi.org/10.2174/138945006776054960 ER - TY - JOUR T1 - Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task AN - 19843654; 6854294 AB - The neuropeptide galanin impairs learning and memory in rodents. The mechanism underlying the cognitive effects of galanin may be related to inhibitory effects of galanin on cholinergic transmission. As cholinergic function is thought to modulate sustained attention, the present study examined whether galanin-overexpressing transgenic mice have impairments in sustained attention. Galanin transgenic (GAL-tg) mice and wild-type (WT) littermate controls were trained in a 5-choice serial reaction time task, modified to assess sustained attention. GAL-tg and WT mice performed similarly during acquisition with respect to accuracy, total omissions, and response speed. Attentional mechanisms were challenged by parametric changes including increased event rate, event asynchrony, or decreased stimulus duration. Singly, these challenges did not differentially affect performance between genotypes. Concurrent administration of these challenges, which represents an optimal test of sustained attention, also had similar effects on GAL-tg and WT mice. When stimulus discriminability was reduced by constant illumination of the house light, GAL-tg mice omitted more trials than WT mice, but other measures of performance did not differ by genotype. Moreover, intraventricular injection of galanin in WT mice did not affect sustained attention. These data indicate that previously reported learning and memory effects of galanin are not secondary to attentional dysfunction. JF - Pharmacology Biochemistry and Behavior AU - Wrenn, Craige C AU - Turchi, Janita N AU - Schlosser, Sophie AU - Dreiling, Jennifer L AU - Stephenson, Dejaimenay A AU - Crawley, Jacqueline N AD - Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA, craige.wrenn@drake.edu Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 428 EP - 440 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 83 IS - 3 SN - 0091-3057, 0091-3057 KW - Transgenic mice KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Galanin KW - Attention KW - Mice KW - Five-choice KW - Operant KW - Transgenic KW - Neuropeptide KW - Acetylcholine KW - Learning KW - Data processing KW - Genotypes KW - Light effects KW - Memory KW - Serial learning KW - Illumination KW - Cholinergic transmission KW - Cognitive ability KW - Reaction time task KW - Neuropeptides KW - W 30925:Genetic Engineering KW - N3 11046:Memory and learning KW - Y 25517:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Performance+of+galanin+transgenic+mice+in+the+5-choice+serial+reaction+time+attentional+task&rft.au=Wrenn%2C+Craige+C%3BTurchi%2C+Janita+N%3BSchlosser%2C+Sophie%3BDreiling%2C+Jennifer+L%3BStephenson%2C+Dejaimenay+A%3BCrawley%2C+Jacqueline+N&rft.aulast=Wrenn&rft.aufirst=Craige&rft.date=2006-03-01&rft.volume=83&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2006.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Learning; Data processing; Genotypes; Transgenic mice; Light effects; Galanin; Serial learning; Memory; Cholinergic transmission; Illumination; Reaction time task; Cognitive ability; Attention; Neuropeptides DO - http://dx.doi.org/10.1016/j.pbb.2006.03.003 ER - TY - JOUR T1 - Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani AN - 19841166; 6765881 AB - Fusarium spp. have emerged as important causes of invasive fungal infections in immunocompromised patients. Rabbit pulmonary alveolar macrophages (PAMs) exhibited fungicidal activity against conidia of Fusarium solani and achieved a time-dependent increase in killing. Neither deoxycholate amphotericin B (DAMB) nor amphotericin B lipid complex (ABLC) exerted a suppressive effect on PAMs by decreasing their conidiocidal activity against F. solani. On the contrary, at a concentration of 0.125 mu g ml super(-1), ABLC and, to a lesser degree, DAMB additively augmented the fungicidal activity of pulmonary alveolar macrophages against conidia of Fusarium solani. JF - Mycoses AU - Roilides, Emmanuel AU - Lyman, Caron A AU - Armstrong, Derek AU - Stergiopoulou, Theodouli AU - Petraitiene, Ruta AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MA, USA, walsht@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 109 EP - 113 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 49 IS - 2 SN - 0933-7407, 0933-7407 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Fusarium solani KW - pulmonary alveolar macrophages KW - amphotericin B formulations KW - Macrophages KW - Amphotericin B KW - Lung KW - Lipids KW - Immunocompromised hosts KW - Fungicidal activity KW - Antifungal activity KW - Conidia KW - Infection KW - Alveoli KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19841166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mycoses&rft.atitle=Deoxycholate+amphotericin+B+and+amphotericin+B+lipid+complex+exert+additive+antifungal+activity+in+combination+with+pulmonary+alveolar+macrophages+against+Fusarium+solani&rft.au=Roilides%2C+Emmanuel%3BLyman%2C+Caron+A%3BArmstrong%2C+Derek%3BStergiopoulou%2C+Theodouli%3BPetraitiene%2C+Ruta%3BWalsh%2C+Thomas+J&rft.aulast=Roilides&rft.aufirst=Emmanuel&rft.date=2006-03-01&rft.volume=49&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Mycoses&rft.issn=09337407&rft_id=info:doi/10.1111%2Fj.1439-0507.2006.01202.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 1; tables, 1. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Amphotericin B; Lung; Immunocompromised hosts; Lipids; Antifungal activity; Fungicidal activity; Conidia; Infection; Alveoli; Fusarium solani DO - http://dx.doi.org/10.1111/j.1439-0507.2006.01202.x ER - TY - JOUR T1 - AAV transcytosis through barrier epithelia and endothelium AN - 19836948; 6818145 AB - To transduce efficiently barrier epithelia such as the lung is the goal of several gene therapy applications. However, experiments with AAV-2 suggest that transduction is limited in this type of barrier epithelia. In contrast, other serotypes of AAV transduce barrier epithelia and exhibit broad dissemination throughout the tissue. Transcytosis is a process by which proteins and pathogens overcome barrier layers to reach the opposite cell surface. To understand better the entry pathway of AAV particles and their ability to penetrate barrier epithelia, we tested the hypothesis that the limited transduction of some barrier epithelia in vitro or the spread of some AAV serotypes through tissue in vivo is due to transcytosis. Our experiments demonstrate that dependoviruses can penetrate barrier cells by transcytosis. The process is rapid as well as serotype and cell-type specific and can be blocked by neutralizing antibodies, temperature, or chemical inhibitors of transcytosis. The particles isolated following apical-to-basolateral transport are still encapsulated and they can transduce permissive cell lines in vitro. Furthermore, the entry pathway used by AAV-5 for transcytosis appears to be independent of the one used for transduction. Importantly, inhibition of virus transcytosis results in a dramatic increase in intracellular vector and transduction. JF - Molecular Therapy AU - Di Pasquale, Giovanni AU - Chiorini, John A AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 506 EP - 516 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 3 SN - 1525-0016, 1525-0016 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - adeno-associated virus KW - transcytosis KW - virus entry KW - virus trafficking KW - Temperature effects KW - Expression vectors KW - Cell surface KW - Antibodies KW - Serotypes KW - Gene therapy KW - Permissive cells KW - Lung KW - Endothelium KW - Pathogens KW - Adeno-associated virus KW - W3 33181:Gene therapy vectors KW - V 22410:Animal Diseases KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19836948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=AAV+transcytosis+through+barrier+epithelia+and+endothelium&rft.au=Di+Pasquale%2C+Giovanni%3BChiorini%2C+John+A&rft.aulast=Di+Pasquale&rft.aufirst=Giovanni&rft.date=2006-03-01&rft.volume=13&rft.issue=3&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1016%2Fj.ymthe.2005.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Expression vectors; Temperature effects; Cell surface; Antibodies; Serotypes; Gene therapy; Lung; Permissive cells; Endothelium; Pathogens; Adeno-associated virus DO - http://dx.doi.org/10.1016/j.ymthe.2005.11.007 ER - TY - JOUR T1 - High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes AN - 19772084; 6749405 AB - With current concerns of antibiotic-resistant bacteria and biodefense, it has become important to rapidly identify infectious bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are time-consuming. We report a rapid and simple method that combines in vivo biotinylation of engineered host-specific bacteriophage and conjugation of the phage to streptavidin-coated quantum dots. The method provides specific detection of as few as 10 bacterial cells per milliliter in experimental samples, with an approximately 100-fold amplification of the signal over background in 1 h. We believe that the method can be applied to any bacteria susceptible to specific phages and would be particularly useful for detection of bacterial strains that are slow growing, e.g., Mycobacterium, or are highly infectious, e.g., Bacillus anthracis. The potential for simultaneous detection of different bacterial species in a single sample and applications in the study of phage biology are discussed. JF - Proceedings of the National Academy of Sciences, USA AU - Edgar, Rotem AU - McKinstry, Michael AU - Hwang, Jeeseong AU - Oppenheim, Amos B AU - Fekete, Richard A AU - Giulian, Gary AU - Merril, Carl AU - Nagashima, Kunio AU - Adhya, Sankar AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 4841 EP - 4845 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 13 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Conjugation KW - Mycobacterium KW - Quantum dots KW - Bacillus anthracis KW - Biotinylation KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=High-sensitivity+bacterial+detection+using+biotin-tagged+phage+and+quantum-dot+nanocomplexes&rft.au=Edgar%2C+Rotem%3BMcKinstry%2C+Michael%3BHwang%2C+Jeeseong%3BOppenheim%2C+Amos+B%3BFekete%2C+Richard+A%3BGiulian%2C+Gary%3BMerril%2C+Carl%3BNagashima%2C+Kunio%3BAdhya%2C+Sankar&rft.aulast=Edgar&rft.aufirst=Rotem&rft.date=2006-03-01&rft.volume=103&rft.issue=13&rft.spage=4841&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Conjugation; Quantum dots; Biotinylation; Mycobacterium; Bacillus anthracis ER - TY - JOUR T1 - Enhanced soluble protein expression using two new fusion tags AN - 19770442; 6726517 AB - Production of soluble recombinant proteins is vital for structure-function analysis and therapeutic applications. Unfortunately, when expressed in a heterologous host, such as Escherichia coli, most proteins are expressed as insoluble aggregates. Two new fusion partners have been identified to address these solubility problems. One of the tags was derived from a bacteriophage T7 protein kinase and the other one from a small E. coli chaperone, Skp. We have expressed a panel of insoluble human proteins including Hifl alpha , IL13, and folliculin as fusion proteins using these tags. Most of these fusion proteins were able to be expressed in a soluble form and could be purified by virtue of a Strep-tag II installed at the amino-terminal end of the fusion partners. In addition, we show that some of these proteins remained soluble after removal of the fusion tags by a site-specific protease. The results with these tags compare favorably to results with the most commonly used solubility tags described in the literature. Therefore, these two new fusion tags have the potential to express soluble proteins when fused with many recalcitrant proteins. JF - Protein Expression and Purification AU - Chatterjee, D K AU - Esposito, D AD - Protein Expression Laboratory, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Building 327 Frederick, MD 21702, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 122 EP - 129 VL - 46 IS - 1 SN - 1046-5928, 1046-5928 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Phages KW - Interleukin 13 KW - Solubility KW - T7 protein KW - Escherichia coli KW - Therapeutic applications KW - Proteinase KW - Chaperones KW - Fusion protein KW - protein purification KW - W 30925:Genetic Engineering KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Enhanced+soluble+protein+expression+using+two+new+fusion+tags&rft.au=Chatterjee%2C+D+K%3BEsposito%2C+D&rft.aulast=Chatterjee&rft.aufirst=D&rft.date=2006-03-01&rft.volume=46&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2005.07.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Interleukin 13; Solubility; T7 protein; Therapeutic applications; Chaperones; Proteinase; protein purification; Fusion protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.pep.2005.07.028 ER - TY - JOUR T1 - Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals AN - 19715644; 7494338 AB - Studies [Zhou, D., Chen, L.-M., Hernandez, L., Shears, S.B., and Galan, J.E. (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host-cell actin cytoskeleton rearrangements and bacterial internalization. Mol. Microbiol. 39, 248-259] with engineered Salmonella mutants showed that deletion of SopE attenuated the pathogen's ability to deplete host-cell InsP5 and remodel the cytoskeleton. We pursued these observations: In SopE-transfected host-cells, membrane ruffling was induced, but SopE did not dephosphorylate InsP5, nor did it recruit PTEN (a cytosolic InsP5 phosphatase) for this task. However, PTEN strengthened SopE-mediated membrane ruffling. We conclude SopE promotes host-cell InsP5 hydrolysis only with the assistance of other Salmonella proteins. Our demonstration that Salmonella-mediated cytoskeletal modifications are independent of inositolphosphates will focus future studies on elucidating alternate pathogenic consequences of InsP5 metabolism, including ion channel conductance and apoptosis. JF - FEBS Letters AU - Deleu, Sandrine AU - Choi, Kuicheon AU - Reece, Jeff M AU - Shears, Stephen B AD - Inositol Signaling Section, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA, shears@niehs.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1709 EP - 1715 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 580 IS - 7 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology KW - SopE KW - InsP5 KW - Inositolphosphate KW - Cytoskeleton KW - Membrane ruffling KW - Salmonella KW - Apoptosis KW - Conductance KW - Inositol KW - PTEN protein KW - Hydrolysis KW - inositol phosphate KW - Pathogenicity KW - Ion channels KW - Actin KW - Metabolism KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19715644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Pathogenicity+of+Salmonella%3A+SopE-mediated+membrane+ruffling+is+independent+of+inositol+phosphate+signals&rft.au=Deleu%2C+Sandrine%3BChoi%2C+Kuicheon%3BReece%2C+Jeff+M%3BShears%2C+Stephen+B&rft.aulast=Deleu&rft.aufirst=Sandrine&rft.date=2006-03-01&rft.volume=580&rft.issue=7&rft.spage=1709&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2006.02.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Apoptosis; Pathogenicity; inositol phosphate; Conductance; Membrane ruffling; Inositol; Ion channels; Actin; PTEN protein; Hydrolysis; Metabolism; Salmonella DO - http://dx.doi.org/10.1016/j.febslet.2006.02.019 ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19690714; 7456858 AB - To compare global and regional myocardial infarction (MI) measurements on clinical gadolinium-enhanced magnetic resonance (MR) images using human manual contouring and a computer algorithm previously validated by histopathology, and to study the degree to which visual assessment and human contouring of infarct extent agreed with the computer algorithm. Infarct size in 20 patients was measured by human manual contouring and with an automated feature analysis and combined thresholding (FACT) computer algorithm. Short-axis slices were divided into myocardial sectors for regional analysis. Extent of infarction was also graded visually by consensus of expert readers and compared to human and computer contouring. Despite good correlations (R = 0.93-0.95) between human contouring and the FACT algorithm, human contouring overestimated infarct size by 3.8% of the left ventricle (23.8% of the MI) area (P < 0.001). Human contouring also overestimated the circumferential extent, transmural extent, and extent of infarction within a sector by 7.1%, 18.2%, and 27.9%, respectively (all P < 0.001). Both consensus reading and human contouring overestimated infarct grades compared with the FACT algorithm (P = 0.002 and P < 0.001). Clinically relevant overestimation of MI can occur in visual interpretation and in human manual contouring, particularly with respect to extent of infarction on a regional basis. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Ingkanisorn, WPatricia AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 309 EP - 314 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - myocardial viability KW - magnetic resonance imaging KW - computer aided diagnosis KW - contrast agent KW - gadolinium KW - Ventricle KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+II%3A+Clinical+application+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BIngkanisorn%2C+WPatricia%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20495 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ventricle; Computers; Magnetic resonance imaging; Algorithms; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20495 ER - TY - JOUR T1 - Quantitative myocardial perfusion analysis with a dual-bolus contrast- enhanced first-pass MRI technique in humans AN - 19690396; 7456868 AB - To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual-bolus first-pass perfusion MRI method in humans. Rest and dipyridamole stress perfusion imaging was performed on 10 healthy humans by administering gadolinium contrast using a dual-bolus protocol. Ventricular and myocardial time-signal intensity curves were generated from a series of T1-weighted images and adjusted for surface-coil intensity variations. Corrected signal intensity curves were then fitted using fully quantitative model constrained deconvolution (MCD) to quantify MBF (mL/min/g) and MPR. The results were compared with semiquantitative contrast enhancement ratio (CER) and upslope index (SLP) measurements. MBF (mL/min/g) estimated with MCD averaged 1.02 +/- 0.22 at rest and 3.39 +/- 0.59 for stress with no overlap in measures. MPR was 3.43 +/- 0.71, 1.91 +/- 0.65, and 1.16 +/- 0.19 using MCD, SLP, and CER. Both semiquantitative parameters (SLP and CER) significantly underestimated MPR (P < 0.001) and failed to completely discriminate rest and stress perfusion. Rest and stress MBF (mL/min/g) and MPR estimated by dual-bolus perfusion MRI fit within published ranges. Semiquantitative methods (SLP and CER) significantly underestimated MPR. J. Magn. Reson. Imaging 2006. Published by Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Rhoads, Kenneth L AU - Holly, Jessica E AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 315 EP - 322 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - magnetic resonance imaging KW - myocardial perfusion KW - myocardial blood flow KW - myocardial perfusion reserve KW - contrast agent KW - gadolinium KW - Perfusion KW - Magnetic resonance imaging KW - Gadolinium KW - Stress KW - Dipyridamole KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+perfusion+analysis+with+a+dual-bolus+contrast-+enhanced+first-pass+MRI+technique+in+humans&rft.au=Hsu%2C+Li-Yueh%3BRhoads%2C+Kenneth+L%3BHolly%2C+Jessica+E%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Perfusion; Gadolinium; Magnetic resonance imaging; Stress; Dipyridamole; Models DO - http://dx.doi.org/10.1002/jmri.20502 ER - TY - JOUR T1 - Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents AN - 19681921; 8169528 AB - Aberrant signaling through protein-tyrosine kinase (PTK)-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth factor receptor bound protein 2 (Grb2) is an important downstream mediator of PTK signaling that serves obligatory roles in many pathogenic processes. One of the primary functions of Grb2 is to bind to specific phosphotyrosyl (pTyr)-containing sequences through its Src homology 2 (SH2) domain. Agents that bind to the Grb2 SH2 domain and prevent its normal function could disrupt associated PTK signaling and serve as alternatives to kinase-directed inhibitors. Starting from the X-ray crystal structure of a lead peptide bound to the Grb2 SH2 domain, this review will summarize important contributions to these efforts. The presentation will be thematically arranged according to the region of peptide modified, proceeding from the N-terminus to the C-terminus, with a special section devoted to aspects of conformational constraint. JF - International Journal of Peptide Research and Therapeutics AU - Burke, Terrence R AD - NCI-Frederick, Bldg. 376 Boyles St., P.O. Box B, Frederick, MD, 21702-1201, USA, tburke@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 33 EP - 48 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 12 IS - 1 SN - 1573-3149, 1573-3149 KW - Biotechnology and Bioengineering Abstracts KW - Grb2 protein KW - C-Terminus KW - Cancer KW - Antagonists KW - N-Terminus KW - Homology KW - Growth factor receptors KW - Reviews KW - Ionizing radiation KW - Protein-tyrosine kinase KW - Src protein KW - Crystal structure KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Peptide+Research+and+Therapeutics&rft.atitle=Development+of+Grb2+SH2+Domain+Signaling+Antagonists%3A+A+Potential+New+Class+of+Antiproliferative+Agents&rft.au=Burke%2C+Terrence+R&rft.aulast=Burke&rft.aufirst=Terrence&rft.date=2006-03-01&rft.volume=XI&rft.issue=2-3&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Journal+of+British+Cinema+and+Television&rft.issn=17434521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Grb2 protein; C-Terminus; Antagonists; Cancer; N-Terminus; Homology; Ionizing radiation; Reviews; Growth factor receptors; Protein-tyrosine kinase; Crystal structure; Src protein; Signal transduction DO - http://dx.doi.org/10.1007/s10989-006-9014-7 ER - TY - JOUR T1 - Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm AN - 19681796; 7456859 AB - To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference. Delayed enhancement MR was performed in 11 dogs with myocardial infarction (MI) determined by triphenyltetrazolium chloride (TTC). Infarct size on in vivo and ex vivo images was measured by a computer algorithm based on automated feature analysis and combined thresholding (FACT). For comparison, infarct size by human manual contouring and simple intensity thresholding (based on two standard deviation [2SD] and full width at half maximum [FWHM]) were studied. Both in vivo and ex vivo MR infarct size measured by the FACT algorithm correlated well with TTC (R = 0.95-0.97) and showed no significant bias on Bland Altman analysis (P = not significant). Despite similar correlations (R = 0.91-0.97), human manual contouring overestimated in vivo MR infarct size by 5.4% of the left ventricular (LV) area (equivalent to 55.1% of the MI area) vs. TTC (P < 0.001). Infarct size measured by simple intensity thresholdings was less accurate than the proposed algorithm (P < 0.001 and P = 0.007). The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches. J. Magn. Reson. Imaging 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Hsu, Li-Yueh AU - Natanzon, Alex AU - Kellman, Peter AU - Hirsch, Glenn A AU - Aletras, Anthony H AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 298 EP - 308 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 23 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - myocardial infarction KW - magnetic resonance imaging KW - computer algorithm KW - image processing KW - expert system KW - contrast agent KW - gadolinium KW - Standard deviation KW - Computers KW - Magnetic resonance imaging KW - Algorithms KW - Triphenyltetrazolium chloride KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Quantitative+myocardial+infarction+on+delayed+enhancement+MRI.+Part+I%3A+Animal+validation+of+an+automated+feature+analysis+and+combined+thresholding+infarct+sizing+algorithm&rft.au=Hsu%2C+Li-Yueh%3BNatanzon%2C+Alex%3BKellman%2C+Peter%3BHirsch%2C+Glenn+A%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2006-03-01&rft.volume=23&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standard deviation; Computers; Magnetic resonance imaging; Algorithms; Triphenyltetrazolium chloride; Myocardial infarction DO - http://dx.doi.org/10.1002/jmri.20496 ER - TY - JOUR T1 - Bombesin/Gastrin-Releasing Peptide Receptor Antagonists Increase the Ability of Histone Deacetylase Inhibitors to Reduce Lung Cancer Proliferation AN - 19648772; 7393109 AB - The effects of a bombesin/gastrin releasing peptide (BB/GRP) receptor antagonist, PD176252, and histone deacetylase (HDAC) Inhibitor, MS-275, were investigated on human lung cancer cell lines. Using the MTT assay, PD176252 and MS-275 inhibited the proliferation of NCI-H1299 cells with IC sub(50) values of 7 and 5 mu g/mL, respectively. Using MS-275 and PD176252 together, the ability to inhibit lung cancer cellular growth increased significantly. The combination index for MS-275 and PD176252 was <0.2, indicating that the compounds are highly synergistic in inhibiting lung cancer cellular growth. Also, MS-275 and PD176252 together strongly inhibited the cional growth of NCI-H345 or NCI-H1299 cells. MS-275 had little effect on the expression of lung cancer cellular GRP or GRP receptors, but increased expression of transforming growth factor- beta receptor II (TGF- beta RII). These results indicate that GRP receptor antagonists may potentiate the action of histone deacetylase inhibitors on lung cancer cellular proliferation by increasing expression of tumor suppressor genes. JF - Journal of Molecular Neuroscience AU - Moody, T W AU - Nakagawa, T AU - Kang, Y AU - Jakowlew, S AU - Chan, D AU - Jensen, R T AD - Department of Health and Human Services, Office of the Director, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 231 EP - 238 VL - 28 IS - 3 SN - 0895-8696, 0895-8696 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gastrin-releasing peptide KW - Histone deacetylase KW - Tumor suppressor genes KW - Tumor cell lines KW - Transforming growth factor- beta KW - Bombesin KW - Gastrin KW - transforming growth factor- beta receptors KW - Cell proliferation KW - Antagonists KW - Lung cancer KW - N3 11007:Neurobiology KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19648772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Neuroscience&rft.atitle=Bombesin%2FGastrin-Releasing+Peptide+Receptor+Antagonists+Increase+the+Ability+of+Histone+Deacetylase+Inhibitors+to+Reduce+Lung+Cancer+Proliferation&rft.au=Moody%2C+T+W%3BNakagawa%2C+T%3BKang%2C+Y%3BJakowlew%2C+S%3BChan%2C+D%3BJensen%2C+R+T&rft.aulast=Moody&rft.aufirst=T&rft.date=2006-03-01&rft.volume=28&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Neuroscience&rft.issn=08958696&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gastrin-releasing peptide; Tumor suppressor genes; Histone deacetylase; Tumor cell lines; Transforming growth factor- beta; Gastrin; Bombesin; transforming growth factor- beta receptors; Cell proliferation; Antagonists; Lung cancer ER - TY - JOUR T1 - Effects of early and later family violence on children's behavior problems and depression: A longitudinal, multi-informant perspective AN - 19455695; 7639264 AB - Objectives To examine the effects of different forms of family violence at two developmental stages by assessing a sample of 110 Israeli children, drawn from the case files of Israeli family service agencies, studied longitudinally in both middle childhood and adolescence. Methods Information about the children's adjustment was obtained from parents, teachers, and the children themselves when the children averaged 10.6 and 15.9 years of age using the Child Behavior Checklist (CBCL), Teacher Report Form (TRF), Youth Self-Report (YSR), and Children's Depression Inventory (CDI). Information about the history of family violence was obtained from the mothers, fathers, children, and social workers. Results The results paint a mixed picture of the effects of family violence on children and adolescents. The relationship between concurrent behavior problems and abuse group varied by informant and study phase, although they were strongest when children were the informants. Predictions regarding the relationship between early abuse and later adjustment were only partially confirmed. Different informants did not agree about which groups of children were most adversely affected, there was little stability over time in the pattern of reported effects, and children were more likely than other informants to report levels of maladjustment that varied depending on recent or concurrent exposure to family violence. Many families changed their abuse status over time, and children who were new victims at follow-up had the most internalizing problems. Girls were found to be at more risk for internalizing and externalizing behavior problems than boys. Conclusions Multiple informants are necessary to evaluate and assess the effects of family violence on children's behavior. Younger children may be more susceptible to the effects of family violence than older children, but problems manifest by some children may not carry over to adolescence. Changes in family and parenting practices, as well as in children's capacity to appraise and cope with family violence may help mitigate the adverse effects of family violence. JF - Child Abuse & Neglect AU - Sternberg, Kathleen J AU - Lamb, Michael E AU - Guterman, Eva AU - Abbott, Craig B AD - National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, United States Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 283 EP - 306 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 3 SN - 0145-2134, 0145-2134 KW - Risk Abstracts KW - Family violence KW - Child abuse KW - Internalizing behavior problems KW - Externalizing behavior problems KW - Maladjustment KW - Historical account KW - Behavior KW - developmental stages KW - Children KW - Violence KW - depression KW - Side effects KW - Adolescents KW - Paints KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19455695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+%26+Neglect&rft.atitle=Effects+of+early+and+later+family+violence+on+children%27s+behavior+problems+and+depression%3A+A+longitudinal%2C+multi-informant+perspective&rft.au=Sternberg%2C+Kathleen+J%3BLamb%2C+Michael+E%3BGuterman%2C+Eva%3BAbbott%2C+Craig+B&rft.aulast=Sternberg&rft.aufirst=Kathleen&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+%26+Neglect&rft.issn=01452134&rft_id=info:doi/10.1016%2Fj.chiabu.2005.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Historical account; Behavior; developmental stages; Children; depression; Violence; Adolescents; Side effects; Paints DO - http://dx.doi.org/10.1016/j.chiabu.2005.10.008 ER - TY - JOUR T1 - Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease AN - 19447141; 6752862 AB - The umbilical cord contains an inexhaustible, noncontroversial source of stem cells for therapy. In the U.S., stem cells found in the umbilical cord are routinely placed into bio-hazardous waste after birth. Here, stem cells derived from human umbilical cord Wharton's Jelly, called umbilical cord matrix stem (UCMS) cells, are characterized. UCMS cells have several properties that make them of interest as a source of cells for therapeutic use. For example, they 1) can be isolated in large numbers, 2) are negative for CD34 and CD45, 3) grow robustly and can be frozen/thawed, 4) can be clonally expanded, and 5) can easily be engineered to express exogenous proteins. UCMS cells have genetic and surface markers of mesenchymal stem cells (positive for CD10, CD13, CD29, CD44, and CD90 and negative for CD14, CD33, CD56, CD31, CD34, CD45, and HLA-DR) and appear to be stable in terms of their surface marker expression in early passage (passages 4-8). Unlike traditional mesenchymal stem cells derived from adult bone marrow stromal cells, small populations of UCMS cells express endoglin (SH2, CD105) and CD49e at passage 8. UCMS cells express growth factors and angiogenic factors, suggesting that they may be used to treat neurodegenerative disease. To test the therapeutic value of UCMS cells, undifferentiated human UCMS cells were transplanted into the brains of hemiparkinsonian rats that were not immune-suppressed. UCMS cells ameliorated apomorphine-induced rotations in the pilot test. UCMS cells transplanted into normal rats did not produce brain tumors, rotational behavior, or a frank host immune rejection response. In summary, the umbilical cord matrix appears to be a rich, noncontroversial, and inexhaustible source of primitive mesenchymal stem cells. JF - Stem Cells AU - Weiss, Mark L AU - Medicetty, Satish AU - Bledsoe, Amber R AU - Rachakatla, Raja Shekar AU - Choi, Michael AU - Merchav, Shosh AU - Luo, Yongquan AU - Rao, Mahendra S AU - Velagaleti, Gopalrao AU - Troyer, Deryl AD - Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, USA. ViaCell Singapore Research Centre, Singapore. Laboratory of Neuroscience, National Institute on Aging, Bethesda, Maryland, USA. Children's Hospital, Galveston, Texas, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 781 EP - 792 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Histocompatibility antigen HLA KW - CD13 antigen KW - stromal cells KW - Parkinson's disease KW - Umbilical cord KW - Stem cells KW - CD105 antigen KW - CD45 antigen KW - Wastes KW - CD34 antigen KW - Movement disorders KW - CD90 antigen KW - Endoglin KW - CD44 antigen KW - Animal models KW - Bone marrow KW - Angiogenesis KW - CD14 antigen KW - Rotational behavior KW - Growth factors KW - Mesenchyme KW - Transplantation KW - CD56 antigen KW - Brain tumors KW - Neurodegenerative diseases KW - Surface markers KW - W 30905:Medical Applications KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19447141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Human+Umbilical+Cord+Matrix+Stem+Cells%3A+Preliminary+Characterization+and+Effect+of+Transplantation+in+a+Rodent+Model+of+Parkinson%27s+Disease&rft.au=Weiss%2C+Mark+L%3BMedicetty%2C+Satish%3BBledsoe%2C+Amber+R%3BRachakatla%2C+Raja+Shekar%3BChoi%2C+Michael%3BMerchav%2C+Shosh%3BLuo%2C+Yongquan%3BRao%2C+Mahendra+S%3BVelagaleti%2C+Gopalrao%3BTroyer%2C+Deryl&rft.aulast=Weiss&rft.aufirst=Mark&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stem cells; Umbilical cord; Mesenchyme; Neurodegenerative diseases; CD45 antigen; CD34 antigen; Surface markers; Angiogenesis; CD13 antigen; CD56 antigen; CD105 antigen; Bone marrow; Movement disorders; CD90 antigen; Histocompatibility antigen HLA; Endoglin; CD14 antigen; Wastes; Rotational behavior; Animal models; stromal cells; Transplantation; CD44 antigen; Brain tumors; Parkinson's disease; Growth factors ER - TY - JOUR T1 - Graph Theoretical Insights into Evolution of Multidomain Proteins AN - 19440070; 6833527 AB - We study properties of multidomain proteins from a graph theoretical perspective. In particular, we demonstrate connections between properties of the domain overlap graph and certain variants of Dollo parsimony models. We apply our graph theoretical results to address several interrelated questions: do proteins acquire new domains infrequently, or often enough that the same combinations of domains will be created repeatedly through independent events? Once domain architectures are created do they persist? In other words, is the existence of ancestral proteins with domain compositions not observed in contemporary proteins unlikely? Our experimental results indicate that independent merges of domain pairs are not uncommon in large superfamilies. JF - Journal of Computational Biology AU - Przytycka, T AU - Davis, G AU - Song, N AU - Durand, D AD - National Center for Biotechnology Information, US Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, przytyck@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 351 EP - 363 VL - 13 IS - 2 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Computer applications KW - Evolution KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Graph+Theoretical+Insights+into+Evolution+of+Multidomain+Proteins&rft.au=Przytycka%2C+T%3BDavis%2C+G%3BSong%2C+N%3BDurand%2C+D&rft.aulast=Przytycka&rft.aufirst=T&rft.date=2006-03-01&rft.volume=13&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Evolution; Models; Computer applications ER - TY - JOUR T1 - Assessing Self-Renewal and Differentiation in Human Embryonic Stem Cell Lines AN - 19438241; 6752835 AB - Like other cell populations, undifferentiated human embryonic stem cells (hESCs) express a characteristic set of proteins and mRNA that is unique to the cells regardless of culture conditions, number of passages, and methods of propagation. We sought to identify a small set of markers that would serve as a reliable indicator of the balance of undifferentiated and differentiated cells in hESC populations. Markers of undifferentiated cells should be rapidly downregulated as the cells differentiate to form embryoid bodies (EBs), whereas markers that are absent or low during the undifferentiated state but that are induced as hESCs differentiate could be used to assess the presence of differentiated cells in the cultures. In this paper, we describe a list of markers that reliably distinguish undifferentiated and differentiated cells. An initial list of approximately 150 genes was generated by scanning published massively parallel signature sequencing, expressed sequence tag scan, and microarray datasets. From this list, a subset of 109 genes was selected that included 55 candidate markers of undifferentiated cells, 46 markers of hESC derivatives, four germ cell markers, and four trophoblast markers. Expression of these candidate marker genes was analyzed in undifferentiated hESCs and differentiating EB populations in four different lines by immunocytochemistry, reverse transcription-polymer-ase chain reaction (RT-PCR), microarray analysis, and quantitative RT-PCR (qPCR). We show that qPCR, with as few as 12 selected genes, can reliably distinguish differentiated cells from undifferentiated hESC populations. JF - Stem Cells AU - Cai, Jingli AU - Chen, Jia AU - Liu, Ying AU - Miura, Takumi AU - Luo, Yongquan AU - Loring, Jeanne F AU - Freed, William J AU - Rao, Mahendra S AU - Zeng, Xianmin AD - Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services (DHHS), Baltimore, Maryland, USA. Cellular Neurobiology Branch, National Institute on Drug Abuse, DHHS, Baltimore, Maryland, USA. Program in Stem Cells and Regeneration, The Burnham Institute, La Jolla, California, USA. Invitrogen, Carlsbad, California, USA. Buck Insititute, Novato, California, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 516 EP - 530 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunocytochemistry KW - Differentiation KW - Stem cells KW - Embryo cells KW - Scanning KW - Germ cells KW - Polymerase chain reaction KW - Trophoblasts KW - Cell culture KW - DNA microarrays KW - expressed sequence tags KW - W 30905:Medical Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessing+Self-Renewal+and+Differentiation+in+Human+Embryonic+Stem+Cell+Lines&rft.au=Cai%2C+Jingli%3BChen%2C+Jia%3BLiu%2C+Ying%3BMiura%2C+Takumi%3BLuo%2C+Yongquan%3BLoring%2C+Jeanne+F%3BFreed%2C+William+J%3BRao%2C+Mahendra+S%3BZeng%2C+Xianmin&rft.aulast=Cai&rft.aufirst=Jingli&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Immunocytochemistry; Stem cells; Scanning; Embryo cells; Germ cells; Trophoblasts; Polymerase chain reaction; Cell culture; expressed sequence tags; DNA microarrays ER - TY - JOUR T1 - IMMUNOHEMATOLOGY: The gene overexpressed in polycythemia rubra vera, PRV-1, and the gene encoding a neutrophil alloantigen, NB1, are alleles of a single gene, CD177, in chromosome band 19q13.31 AN - 19438183; 6767049 AB - BACKGROUND: PRV-1 mRNA is overexpressed by neutrophils from polycythemia vera patients and is homologous to NB1 a gene overexpressed in reactive neutrophilia. STUDY DESIGN AND METHODS: These investigations were designed to confirm searches of genome databases suggesting that PRV-1 and NB1 are alleles of the same gene, CD177, and confirm a pseudogene adjacent to CD177. Methods included polymerase chain reaction (PCR), cloning, sequencing, and fluorescent hybridization studies. RESULTS: The coding region of PRV-1 was PCR-amplified from human fetal RNA, cloned, and used to screen the RPCI-11 bacterial artificial chromosome (BAC) library. Five BACs were reactive with the PRV-1 probe. PCR analysis of the BACs with primers encompassing PRV-1 exons, containing four known single-nucleotide polymorphisms, followed by sequencing rendered amplicons identical to PRV-1 in all five BACs. Analysis of all five by restriction digestion yielded fragments possible only if both the gene and the pseudogene are present. End sequencing of the BACs localized them to the same chromosome region. G-banding and fluorescence in situ hybridization at the 400- and 850-band levels of resolution mapped one BAC to chromosome band 19q13.2 and sublocalized the BAC to band 19q13.31, respectively. CONCLUSION: PRV-1 and NB1 are alleles of the same gene now referred to as CD177. Changes in CD177 expression may be a marker of increased or decreased myelopoiesis and are therefore an effect of, rather than a cause of, myeloproliferative disorders. JF - Transfusion AU - Caruccio, Lorraine AU - Bettinotti, Maria AU - Myska, Alison E AU - Arthur, Diane C AU - Stroncek, David AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, lcaruccio@mail.cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 441 EP - 447 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 46 IS - 3 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Polycythemia KW - Genomes KW - Pseudogenes KW - Myelopoiesis KW - Exons KW - DNA probes KW - Leukocytes (neutrophilic) KW - Polycythemia vera KW - Fetuses KW - mRNA KW - Bacterial artificial chromosomes KW - Databases KW - Chromosomes KW - Single-nucleotide polymorphism KW - Alloantigens KW - Polymerase chain reaction KW - Myeloproliferative diseases KW - Primers KW - Neutrophilia KW - Fluorescence in situ hybridization KW - G 07880:Human Genetics KW - J 02400:Human Diseases KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=IMMUNOHEMATOLOGY%3A+The+gene+overexpressed+in+polycythemia+rubra+vera%2C+PRV-1%2C+and+the+gene+encoding+a+neutrophil+alloantigen%2C+NB1%2C+are+alleles+of+a+single+gene%2C+CD177%2C+in+chromosome+band+19q13.31&rft.au=Caruccio%2C+Lorraine%3BBettinotti%2C+Maria%3BMyska%2C+Alison+E%3BArthur%2C+Diane+C%3BStroncek%2C+David&rft.aulast=Caruccio&rft.aufirst=Lorraine&rft.date=2006-03-01&rft.volume=46&rft.issue=3&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2006.00741.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - SuppNotes - Figures, 3; tables, 2; references, 11. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Polycythemia; Pseudogenes; Myelopoiesis; Exons; DNA probes; Leukocytes (neutrophilic); Polycythemia vera; Fetuses; mRNA; Bacterial artificial chromosomes; Databases; Chromosomes; Single-nucleotide polymorphism; Alloantigens; Polymerase chain reaction; Primers; Myeloproliferative diseases; Neutrophilia; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1111/j.1537-2995.2006.00741.x ER - TY - JOUR T1 - Magnetic Resonance Imaging and Confocal Microscopy Studies of Magnetically Labeled Endothelial Progenitor Cells Trafficking to Sites of Tumor Angiogenesis AN - 19432401; 6752850 AB - AC133 cells, a subpopulation of CD34 super(+) hematopoietic stem cells, can transform into endothelial cells that may integrate into the neovasculature of tumors or ischemic tissue. Most current imaging modalities do not allow monitoring of early migration and incorporation of endothelial progenitor cells (EPCs) into tumor neovasculature. The goals of this study were to use magnetic resonance imaging (MRI) to track the migration and incorporation of intravenously injected, magnetically labeled EPCs into the blood vessels in a rapidly growing flank tumor model and to determine whether the pattern of EPC incorporation is related to the time of injection or tumor size. Materials and Methods: EPCs labeled with ferumoxide-protamine sulfate (FePro) complexes were injected into mice bearing xenografted glioma, and MRI was obtained at different stages of tumor development and size. Results: Migration and incorporation of labeled EPCs into tumor neovasculature were detected as low signal intensity on MRI at the tumor periphery as early as 3 days after EPC administration in preformed tumors. However, low signal intensities were not observed in tumors implanted at the time of EPC administration until tumor size reached 1 cm at 12 to 14 days. Prussian blue staining showed iron-positive cells at the sites corresponding to low signal intensity on MRI. Confocal microcopy showed incorporation into the neovasculature, and immunohistochemistry clearly demonstrated the transformation of the administered EPCs into endothelial cells. Conclusion: MRI demonstrated the incorporation of FePro-labeled human CD34 super(+)/AC133 super(+) EPCs into the neovasculature of implanted flank tumors. JF - Stem Cells AU - Arbab, Ali S AU - Frenkel, Victor AU - Pandit, Sunil D AU - Anderson, Stasia A AU - Yocum, Gene T AU - Bur, Monica AU - Khuu, Hanh M AU - Read, Elizabeth J AU - Frank, Joseph A AD - Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Molecular Imaging Laboratory, Clinical Center, National Institute of Neurological Disorders and Stroke, Clinical Center, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA. Radiology, Henry Ford Health System, Detroit, Michigan, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 671 EP - 678 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 3 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Magnetic resonance imaging KW - Animal models KW - Angiogenesis KW - Developmental stages KW - CD34 antigen KW - Ischemia KW - Tumors KW - Sulfate KW - Brain tumors KW - Endothelial cells KW - Stem cells KW - Blood vessels KW - Confocal microscopy KW - Glioma KW - Cell migration KW - Immunohistochemistry KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19432401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Magnetic+Resonance+Imaging+and+Confocal+Microscopy+Studies+of+Magnetically+Labeled+Endothelial+Progenitor+Cells+Trafficking+to+Sites+of+Tumor+Angiogenesis&rft.au=Arbab%2C+Ali+S%3BFrenkel%2C+Victor%3BPandit%2C+Sunil+D%3BAnderson%2C+Stasia+A%3BYocum%2C+Gene+T%3BBur%2C+Monica%3BKhuu%2C+Hanh+M%3BRead%2C+Elizabeth+J%3BFrank%2C+Joseph+A&rft.aulast=Arbab&rft.aufirst=Ali&rft.date=2006-03-01&rft.volume=24&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Magnetic resonance imaging; Stem cells; Cell migration; Endothelial cells; CD34 antigen; Angiogenesis; Developmental stages; Confocal microscopy; Ischemia; Blood vessels; Animal models; Glioma; Brain tumors; Immunohistochemistry; Sulfate; Transformation ER - TY - JOUR T1 - Targeting multidrug resistance in cancer AN - 19429522; 6702422 AB - Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In most cases, multiple drugs are used, as resistance to single agents occurs almost universally. For this reason, elucidation of mechanisms that confer simultaneous resistance to different drugs with different targets and chemical structures-multidrug resistance-has been a major goal of cancer biologists during the past 35 years. Here, we review the most common of these mechanisms, one that relies on drug efflux from cancer cells mediated by ATP- binding cassette (ABC) transporters. We describe various approaches to combating multidrug-resistant cancer, including the development of drugs that engage, evade or exploit efflux by ABC transporters. JF - Nature Reviews: Drug Discovery AU - Szakacs, Gergely AU - Paterson, Jill K AU - Ludwig, Joseph A AU - Booth-Genthe, Catherine AU - Gottesman, Michael M AD - Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest Karolina ut 29; H-1518, Hungary., MGottesman@nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 219 EP - 234 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 5 IS - 3 SN - 1474-1776, 1474-1776 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - ABC transporter KW - Drug resistance KW - Chemotherapy KW - Reviews KW - Drug development KW - Multidrug resistance KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19429522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Targeting+multidrug+resistance+in+cancer&rft.au=Szakacs%2C+Gergely%3BPaterson%2C+Jill+K%3BLudwig%2C+Joseph+A%3BBooth-Genthe%2C+Catherine%3BGottesman%2C+Michael+M&rft.aulast=Szakacs&rft.aufirst=Gergely&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd1984 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Reviews; ABC transporter; Chemotherapy; Drug resistance; Multidrug resistance; Drug development; Metastases DO - http://dx.doi.org/10.1038/nrd1984 ER - TY - JOUR T1 - Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt AN - 19428793; 6753773 AB - The serine/threonine kinase Akt is a promising target in cancer. We previously identified five phosphatidylinositol ether lipid analogues (PIA) that inhibited Akt activation and selectively killed lung and breast cancer cells with high levels of Akt activity. To assess the spectrum of activity in other cell types and to compare PIAs with other inhibitors of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, we compared growth inhibition by PIAs against the PI3K inhibitors LY294002 and wortmannin and the mTOR inhibitor rapamycin in the NCI60 cell line panel. Although each of these compounds inhibited the growth of all the cell lines, distinct patterns were observed. The PIAs were the least potent but the most cytotoxic. The broad spectrum of activity of PIAs was confirmed in vivo in hollow fiber assays. The response to PIAs was significantly correlated with levels of active but not total Akt in the NCI60, as assessed using COMPARE analysis. However, a number of molecular targets were identified whose expression was more highly correlated with sensitivity to PIAs than active Akt. Expression of these molecular targets did not overlap with those that correlated with sensitivity to LY294002, wortmannin, or rapamycin. A COMPARE analysis of the National Cancer Institute chemical screening database revealed that the patterns of activity of PIAs correlated best with patterns of activity of other lipid-based compounds. These studies show that although PIAs are widely active in cancer cells, which correlates with the presence of its intended target, active Akt, PIAs are biologically distinct from other known inhibitors of the PI3K/Akt/mTOR pathway. [Mol Cancer Ther 2006; 5(3):713-22] JF - Molecular Cancer Therapeutics AU - Gills, Joell J AU - Holbeck, Susan AU - Hollingshead, Melinda AU - Hewitt, Stephen M AU - Kozikowski, Alan P AU - Dennis, Phillip A AD - Medical Oncology Branch and Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 713 EP - 722 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 5 IS - 3 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Protein-serine/threonine kinase KW - phosphatidylinositol KW - Lipids KW - Fibers KW - Databases KW - Cytotoxicity KW - 1-Phosphatidylinositol 3-kinase KW - AKT protein KW - Breast cancer KW - Ethers KW - TOR protein KW - Rapamycin KW - Lung cancer KW - Wortmannin KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Spectrum+of+activity+and+molecular+correlates+of+response+to+phosphatidylinositol+ether+lipid+analogues%2C+novel+lipid-based+inhibitors+of+Akt&rft.au=Gills%2C+Joell+J%3BHolbeck%2C+Susan%3BHollingshead%2C+Melinda%3BHewitt%2C+Stephen+M%3BKozikowski%2C+Alan+P%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2006-03-01&rft.volume=5&rft.issue=3&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - AKT protein; 1-Phosphatidylinositol 3-kinase; Lipids; Ethers; Wortmannin; phosphatidylinositol; Rapamycin; Lung cancer; Breast cancer; Databases; Protein-serine/threonine kinase; TOR protein; Cytotoxicity; Fibers ER - TY - JOUR T1 - Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization AN - 19427387; 6703424 AB - Understanding the cell biology of many proteins requires knowledge of their in vivo topological distribution. Here we describe a new fluorescence-based technique, fluorescence protease protection (FPP), for investigating the topology of proteins and for localizing protein subpopulations within the complex environment of the living cell. In the FPP assay, adapted from biochemical protease protection assays, GFP fusion proteins are used as noninvasive tools to obtain details of protein topology and localization within living cells in a rapid and straightforward manner. To demonstrate the broad applicability of FPP, we used the technique to define the topology of proteins localized to a wide range of organelles including the endoplasmic reticulum (ER), Golgi apparatus, mitochondria, peroxisomes and autophagosomes. The success of the FPP assay in characterizing the topology of the tested proteins within their appropriate compartments suggests this technique has wide applicability in studying protein topology and localization within the cell. JF - Nature Methods AU - Lorenz, Holger AU - Hailey, Dale W AU - Lippincott-Schwartz, Jennifer AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 18T Library Drive, Bethesda, Maryland 20892, USA., jlippin@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 205 EP - 210 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 3 SN - 1548-7091, 1548-7091 KW - Biotechnology and Bioengineering Abstracts KW - Golgi apparatus KW - Chimeras KW - Endoplasmic reticulum KW - Fluorescence KW - Mitochondria KW - Proteinase KW - Fusion protein KW - Organelles KW - Peroxisomes KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19427387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=Fluorescence+protease+protection+of+GFP+chimeras+to+reveal+protein+topology+and+subcellular+localization&rft.au=Lorenz%2C+Holger%3BHailey%2C+Dale+W%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Lorenz&rft.aufirst=Holger&rft.date=2006-03-01&rft.volume=3&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth857 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Proteinase; Fluorescence; Endoplasmic reticulum; Organelles; Mitochondria; Fusion protein; Peroxisomes; Chimeras; Golgi apparatus DO - http://dx.doi.org/10.1038/nmeth857 ER - TY - JOUR T1 - How do we do it? Practical advice on imaging-based techniques and investigations AN - 19283253; 8633095 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Goncalves, L F AU - Lee, W AU - Espinoza, J AU - Romero, R AD - Perinatology Research Branch, National Institute of Child Health and Human Development, NIH/DHHS, Bethesda, MD, USA, warfiela@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 336 EP - 348 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 27 IS - 3 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19283253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Risk+of+Large-Scale+Evacuation+Based+on+the+Effectiveness+of+Rescue+Strategies+Under+Different+Crowd+Densities&rft.au=Wang%2C+Jinghong%3BLo%2C+Siuming%3BWang%2C+Qingsong%3BSun%2C+Jinhua%3BMu%2C+Honglin&rft.aulast=Wang&rft.aufirst=Jinghong&rft.date=2013-08-01&rft.volume=33&rft.issue=8&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2012.01923.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Gynecology; Ultrasound DO - http://dx.doi.org/10.1002/uog.2724 ER - TY - JOUR T1 - NMR and Crystallographic Characterization of Adventitious Borate Binding by Trypsin AN - 17699535; 7599126 AB - Recent super(11) B NMR studies of the formation of ternary complexes of trypsin, borate, and S1-binding alcohols revealed evidence for an additional binding interaction external to the enzyme active site. We have explored this binding interaction as a prototypical interaction of borate and boronate ligands with residues on the protein surface. NMR studies of trypsin in which the active site is blocked with leupeptin or with the irreversible inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) indicate the existence of a low-affinity borate binding site with an apparent dissociation constant of 97 mM, measured at pH 8.0. Observation of a field-dependent dynamic frequency shift of the super(11)B resonance indicates that it corresponds to a complex for which cot >> 1. The 0.12 ppm shift difference of the borate resonances measured at 11.75 and 7.05 T, corresponds to a quadrupole coupling constant of 260 kHz. A much larger 2.0 ppm shift is observed in the super(11)B NMR spectra of trypsin complexed with benzene boronic acid (BBA), leading to a calculated quadrupole coupling constant of 1.1 MHz for this complex. Crystallographic studies identify the second borate binding site as a serine-rich region on the surface of the molecule. Specifically, a complex obtained at pH 10.6 shows a borate ion covalently bonded to the hydroxyl oxygen atoms of Ser164 and Ser167, with additional stabilization coming from two hydrogen-bonding interactions. A similar structure, although with low occupancy (30%), is observed for a trypsin-BBA complex. In this case, the BBA is also observed in the active site, covalently bound in two different conformations to both His57 N epsilon and Ser195 O gamma . An analysis of pairwise hydroxyl oxygen distances was able to predict the secondary borate binding site in porcine trypsin, and this approach is potentially useful for prediction of borate binding sites on the surfaces of other proteins. However, the distances between the Ser164/Ser167 O gamma atoms in all of the reported trypsin crystal structures is significantly greater than the O gamma distances of 2.2 and 1.9 A observed in the trypsin complexes with borate and BBA, respectively. Thus, the ability of the hydroxyl oxygens to adopt a sufficiently close orientation to allow bidentate ligation is a critical limit on the borate binding affinity of surface-accessible serine/threonine/tyrosine residues. JF - Bioconjugate Chemistry AU - Transue, T R AU - Gabel, SA AU - London, R E AD - National Institute of Environmental Health Sciences, Laboratory of Structural Biology, Box 12233, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 300 EP - 308 VL - 17 IS - 2 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Leupeptin KW - Trypsin KW - Tyrosine KW - Enzymes KW - Benzene KW - Oxygen KW - Fluoride KW - alcohols KW - Crystal structure KW - N.M.R. KW - Threonine KW - pH effects KW - Serine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17699535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=NMR+and+Crystallographic+Characterization+of+Adventitious+Borate+Binding+by+Trypsin&rft.au=Transue%2C+T+R%3BGabel%2C+SA%3BLondon%2C+R+E&rft.aulast=Transue&rft.aufirst=T&rft.date=2006-03-01&rft.volume=17&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0502210 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Leupeptin; Trypsin; Enzymes; Tyrosine; Benzene; Oxygen; Fluoride; Crystal structure; alcohols; N.M.R.; pH effects; Threonine; Serine DO - http://dx.doi.org/10.1021/bc0502210 ER - TY - JOUR T1 - Pharmacogenetics of irinotecan metabolism and transport: An update AN - 17473213; 6654160 AB - The anticancer agent irinotecan (CPT-11) is converted to SN-38, which is approximately 100 to 1000-fold more cytotoxic than the parent drug. The pharmacokinetics of irinotecan are extremely complex and have been the subject of intensive investigation in recent years. Irinotecan is subject to extensive metabolism by various polymorphic enzymes, including CES2 to form SN-38, members of the UGT1A subfamily, and CYP3A4 and CYP3A5, which form several pharmacologically inactive oxidation products. Elimination of irinotecan is also dependent on drug-transporting proteins, notably ABCB1 (P-glycoprotein), ABCC2 (cMOAT) and ABCG2 (BCRP), present on the bile canalicular membrane. The various processes mediating drug elimination, either through metabolic breakdown or excretion, likely impact substantially on interindividual variability in drug handling. This report provides an update on current strategies to individualize irinotecan chemotherapy based on each patient's genetic constitution, which may ultimately lead to more selective use of this agent. JF - Toxicology In Vitro AU - Smith, Nicola F AU - Figg, William D AU - Sparreboom, Alex AD - Molecular Pharmacology Section, Medical Oncology Branch, National Cancer Institute, 9000 Rockville Pike, Building 10/Room 5A01, Bethesda, MD, USA, wdfigg@helix.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 163 EP - 175 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 20 IS - 2 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - CPT-11 KW - SN-38 KW - CYP3A KW - CES KW - UGT1A KW - ABCB1 KW - ABCC1 KW - ABCC2 KW - ABCG2 KW - Chemotherapy KW - Irinotecan KW - Enzymes KW - Antitumor agents KW - Pharmacokinetics KW - Pharmacogenetics KW - Cytotoxicity KW - P-Glycoprotein KW - Bile KW - Oxidation KW - Excretion KW - Drugs KW - Metabolism KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17473213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Pharmacogenetics+of+irinotecan+metabolism+and+transport%3A+An+update&rft.au=Smith%2C+Nicola+F%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Smith&rft.aufirst=Nicola&rft.date=2006-03-01&rft.volume=20&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2005.06.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemotherapy; Irinotecan; Enzymes; Antitumor agents; Pharmacogenetics; Pharmacokinetics; P-Glycoprotein; Cytotoxicity; Bile; Oxidation; Excretion; Drugs; Metabolism DO - http://dx.doi.org/10.1016/j.tiv.2005.06.045 ER - TY - JOUR T1 - A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 Activity AN - 17260323; 6988132 AB - ABCG2 is a member of the adenosine triphosphate (ATP)-binding cassette family of multidrug transporters associated with resistance of tumor cells to many cytotoxic agents. Evaluation of modulators of ABCG2 activity has relied on methods such as drug sensitization, biochemical characterization, and transport studies. To search for novel inhibitors of ABCG2, a fluorescent cell-based assay was developed for application in high-throughput screening. Accumulation of pheophorbide a (PhA), an ABCG2-specific substrate, forms the basis for the assay in NCI-H460/MX20 cells overexpressing wild-type ABCG2. Treatment of these cells with 10 mu M fumitremorgin C (FTC), a specific ABCG2 inhibitor, increased cell accumulation of PhA to 5.6 times control (Z' 0.5). Validation included confirmation with known ABCG2 inhibitors: FTC, novobiocin, tariquidar, and quercetin. Verapamil, reported to inhibit P-glycoprotein but not ABCG2, had insignificant activity. Screening of a library of 3523 natural products identified 11 compounds with high activity (> 50% of FTC, confirmed by reassay), including 3 flavonoids, members of a family of compounds that include ABCG2 inhibitors. One of the inhibitors detected, eupatin, was moderately potent (IC sub(50) of 2.2 mu M) and, like FTC, restored sensitivity of resistant cells to mitoxantrone. Application of this assay to other libraries of synthetic compounds and natural products is expected to identify novel inhibitors of ABCG2 activity. JF - Journal of Biomolecular Screening AU - Henrich, C J AU - Bokesch, H R AU - Dean, M AU - Bates, SE AU - Robey, R W AU - Goncharova, E I AU - Wilson, JA AU - McMahon, J B AD - Basic Research Program, SAIC-Frederick, Inc., NCI Frederick, Frederick, MD, USA Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 176 EP - 183 VL - 11 IS - 2 SN - 1087-0571, 1087-0571 KW - ABCG2 protein KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - P-Glycoprotein KW - Flavonoids KW - Verapamil KW - Novobiocin KW - ATP KW - natural products KW - Cytotoxic agents KW - high-throughput screening KW - mitoxantrone KW - Tumor cells KW - Quercetin KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17260323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=A+High-Throughput+Cell-Based+Assay+for+Inhibitors+of+ABCG2+Activity&rft.au=Henrich%2C+C+J%3BBokesch%2C+H+R%3BDean%2C+M%3BBates%2C+SE%3BRobey%2C+R+W%3BGoncharova%2C+E+I%3BWilson%2C+JA%3BMcMahon%2C+J+B&rft.aulast=Henrich&rft.aufirst=C&rft.date=2006-03-01&rft.volume=11&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057105284576 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flavonoids; P-Glycoprotein; Verapamil; Novobiocin; ATP; high-throughput screening; Cytotoxic agents; natural products; Quercetin; Tumor cells; mitoxantrone DO - http://dx.doi.org/10.1177/1087057105284576 ER - TY - JOUR T1 - Parthenolide has limited effects on nuclear factor-[kappa] beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice AN - 17191630; 6865622 AB - Parthenolide, a sesquiterpene lactone, inhibited lipopolysaccharide (LPS) stimulated nuclear factor (NF)-[kappa] beta and cytokine production in vitro and in rats, and improved survival in LPS challenged Swiss albino mice. We investigated whether increased survival with parthenolide was associated directly with inhibition of NF-[kappa] beta and cytokines in LPS challenged C57BL/6J mice. In RAW 264.7 cells, parthenolide inhibited LPS-stimulated NF-[kappa] beta and cytokines (interleukin [IL]-1 alpha , -1 beta , -2, -4, -6, and -10, interferon- gamma , tumor necrosis factor- alpha , granulocyte macrophage-colony stimulating factor, migratory inhibitory protein-1 and -2 alpha , JE, and RANTES). In mice (n = 366) receiving lethal intraperitoneal (i.p.) LPS (40 mg/kg), compared to placebo, each of 5 parthenolide doses (0.25 to 4 mg/kg i.p. following LPS) reduced survival at 168 h and overall worsened the hazards ratio of survival (mean +/- S.E.M.) (1.29 +/- 0.12, p = 0.04). In other mice (241), compared to saline challenge, nonlethal LPS (2.5 mg/kg) increased NF-[kappa] beta in lung and kidney combined and 12 of 13 plasma cytokines early (1 and 3 h) and late (6, 9 and 12 h) (p <= 0.002 for each). Compared to nonlethal LPS, lethal LPS increased NF-[kappa] beta and 12 of 13 cytokines early but not significantly and late significantly (p <= 0.05 for each). With lethal LPS, compared to placebo, parthenolide (1 mg/kg) decreased NF-[kappa] beta and 10 of 13 cytokines early and increased NF-[kappa] beta and 11 of 13 cytokines late (p <= 0.02 for early vs. late). Although parthenolide inhibits NF-[kappa] beta and cytokines in vitro, its effects on these mediators and survival in animal sepsis models vary. Theses differences must be understood before parthenolide or related agents are applied clinically for sepsis. JF - Cytokine AU - Li, Xuemei AU - Cui, Xizhong AU - Li, Yan AU - Fitz, Yvonne AU - Hsu, Lewis AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892, USA, peichacker@cc.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 299 EP - 308 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 33 IS - 6 SN - 1043-4666, 1043-4666 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anti-inflammatory agent KW - Lipopolysaccharide KW - Treatment KW - Signaling molecules KW - gamma -Interferon KW - Interleukins KW - Granulocyte-macrophage colony-stimulating factor KW - Animal models KW - Survival KW - RANTES KW - sesquiterpene lactones KW - NF- Kappa B protein KW - Sepsis KW - Lung KW - Kidney KW - Cytokines KW - Lipopolysaccharides KW - Tumor necrosis factor- alpha KW - Cell migration KW - J 02350:Immunology KW - F 06512:Immunopharmacology and general Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17191630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Parthenolide+has+limited+effects+on+nuclear+factor-%5Bkappa%5D+beta+increases+and+worsens+survival+in+lipopolysaccharide-challenged+C57BL%2F6J+mice&rft.au=Li%2C+Xuemei%3BCui%2C+Xizhong%3BLi%2C+Yan%3BFitz%2C+Yvonne%3BHsu%2C+Lewis%3BEichacker%2C+Peter+Q&rft.aulast=Li&rft.aufirst=Xuemei&rft.date=2006-03-01&rft.volume=33&rft.issue=6&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/10.1016%2Fj.cyto.2006.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Animal models; Granulocyte-macrophage colony-stimulating factor; Interleukins; RANTES; Survival; sesquiterpene lactones; NF- Kappa B protein; Sepsis; Lung; Kidney; Lipopolysaccharides; Cytokines; Cell migration; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.cyto.2006.03.002 ER - TY - JOUR T1 - Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism AN - 17172625; 6761917 AB - Coxiella burnetii directs the synthesis of a large parasitophorous vacuole (PV) required for replication. While some lysosomal characteristics of the PV have been described, the origin and composition of the PV membrane is largely undefined. Cholesterol is an essential component of mammalian cell membranes where it plays important regulatory and structural roles. Here we investigated the role of host cholesterol in biogenesis and maintenance of the C. burnetii PV in Vero cells. The C. burnetii PV membrane stained with filipin and was positive for the lipid raft protein flotillin-1, suggesting PV membranes are enriched in cholesterol and contain lipid raft microdomains. C. burnetii infection increased host cell cholesterol content by 1.75-fold with a coincident upregulation of host genes involved in cholesterol metabolism. Treatment with U18666A, lovastatin, or 25-hydroxycholesterol, pharmacological agents that inhibit cholesterol uptake and-or biosynthesis, altered PV morphology and partially inhibited C. burnetii replication. Complete inhibition of C. burnetii PV development and replication was observed when infected cells were treated with imipramine or ketoconazole, inhibitors of cholesterol uptake and biosynthesis respectively. We conclude that C. burnetii infection perturbs host cell cholesterol metabolism and that free access to host cholesterol stores is required for optimal C. burnetii replication. JF - Cellular Microbiology AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, rheinzen@niaid.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 496 EP - 507 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 8 IS - 3 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Vero cells KW - Replication KW - Cholesterol KW - Ketoconazole KW - Infection KW - Lipid rafts KW - Lipid metabolism KW - parasitophorous vacuole KW - Coxiella burnetii KW - Mammalian cells KW - imipramine KW - Vacuoles KW - Lovastatin KW - Evolution KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17172625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Coxiella+burnetii+inhabits+a+cholesterol-rich+vacuole+and+influences+cellular+cholesterol+metabolism&rft.au=Howe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2006-03-01&rft.volume=8&rft.issue=3&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2005.00641.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 7; references, 60. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Vero cells; Replication; Cholesterol; Infection; Ketoconazole; Lipid metabolism; Lipid rafts; parasitophorous vacuole; imipramine; Mammalian cells; Vacuoles; Evolution; Lovastatin; Coxiella burnetii DO - http://dx.doi.org/10.1111/j.1462-5822.2005.00641.x ER - TY - JOUR T1 - Case Reports: Successful Renal Transplantation in Patients with Chronic Granulomatous Disease AN - 17161484; 6760556 AB - Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population, and is often attributed to the necessary use of nephrotoxic anti-infectives. In this report, we present the experiences of two centers in transplantation of three patients with CGD: one transplanted with CGD, one cured of his CGD with bone marrow transplantation who subsequently underwent kidney transplantation and one that received a kidney transplant prior to being cured of CGD via a sequential peripheral blood stem cell transplant (SCT). All three recipients have enjoyed excellent outcomes. Their courses demonstrate the absolute requirements for a multidisciplinary and compulsive approach before, during and after transplantation. These case reports also highlight the unexpectedly benign effects of immunosuppressive therapy in this patient population. JF - American Journal of Transplantation AU - Bolanowski, A AU - Mannon, R B AU - Holland, S M AU - Malech, H L AU - Aschan, J AU - Palmblad, J AU - Hale, DA AU - Kirk, AD AD - Allan D. Kirk, AllanK@intra.niddk.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 636 EP - 639 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 6 IS - 3 SN - 1600-6135, 1600-6135 KW - NADPH oxidase KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Chronic granulomatous disease KW - kidney KW - transplant KW - Kidney transplantation KW - Immunodeficiency KW - Enzymes KW - Peripheral blood KW - Immunosuppressive agents KW - Case reports KW - NAD(P)H oxidase KW - Mutation KW - Bone marrow transplantation KW - Benign KW - End-stage renal disease KW - F 06204:Kidney KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17161484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Transplantation&rft.atitle=Case+Reports%3A+Successful+Renal+Transplantation+in+Patients+with+Chronic+Granulomatous+Disease&rft.au=Bolanowski%2C+A%3BMannon%2C+R+B%3BHolland%2C+S+M%3BMalech%2C+H+L%3BAschan%2C+J%3BPalmblad%2C+J%3BHale%2C+DA%3BKirk%2C+AD&rft.aulast=Bolanowski&rft.aufirst=A&rft.date=2006-03-01&rft.volume=6&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Transplantation&rft.issn=16006135&rft_id=info:doi/10.1111%2Fj.1600-6143.2006.01232.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - SuppNotes - References, 13. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Case reports; Kidney transplantation; Immunodeficiency; Enzymes; NAD(P)H oxidase; Peripheral blood; Chronic granulomatous disease; Mutation; Immunosuppressive agents; Bone marrow transplantation; End-stage renal disease; Benign DO - http://dx.doi.org/10.1111/j.1600-6143.2006.01232.x ER - TY - JOUR T1 - Assessing Weight-Related Quality of Life in Adolescents AN - 17147578; 6814659 AB - OBJECTIVE: The development of a new weight-related measure to assess quality of life in adolescents [Impact of Weight on Quality of Life (IWQOL)-Kids] is described. RESEARCH METHODS AND PROCEDURES: Using a literature search, clinical experience, and consultation with pediatric clinicians, 73 items were developed, pilot tested, and administered to 642 participants, 11 to 19 years old, recruited from weight loss programs/studies and community samples (mean z-BMI, 1.5; range, -1.2 to 3.4; mean age, 14.0; 60% female; 56% white). Participants completed the 73 items and the Pediatric Quality of Life Inventory and were weighed and measured. RESULTS: Four factors (27 items) were identified (physical comfort, body esteem, social life, and family relations), accounting for 71% of the variance. The IWQOL-Kids demonstrated excellent psychometric properties. Internal consistency coefficients ranged from 0.88 to 0.95 for scales and equaled 0.96 for total score. Convergent validity was demonstrated with strong correlations between IWQOL-Kids total score and the Pediatric Quality of Life Inventory (r = 0.76, p < 0.0001). Significant differences were found across BMI groups and between clinical and community samples, supporting the sensitivity of this measure. Participants in a weight loss camp demonstrated improved IWQOL-Kids scores, suggesting responsiveness of the IWQOL-Kids to weight loss/social support intervention. DISCUSSION: The present study provides preliminary evidence regarding the psychometric properties of the IWQOL-Kids, a weight-related quality of life measure for adolescents. Given the rise of obesity in youth, the development of a reliable and valid weight-related measure of quality of life is timely. JF - Obesity Research AU - Kolotkin, Ronette L AU - Zeller, Meg AU - Modi, Avani C AU - Samsa, Gregory P AU - Polanichka Quinlan, Nicole AU - Yanovski, Jack A AU - Bell, Stephen K AU - Maahs, David M AU - Gonzales de Serna, Daniela AU - Roehrig, Helmut R AD - Obesity and Quality of Life Consulting, Durham, North Carolina. Community and Family Medicine, Center for Clinical Health Policy Research, and. Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina. Division of Psychology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio. Department of Psychology, Social and Health Sciences, Duke University, Durham, North Carolina. Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Children's Health System, Children's Behavioral Health, Birmingham, Alabama. Barbara Davis Center for Diabetes, University of Colorado Health Sciences Center, Denver, Colorado. Department of Internal Medicine, University Hospital, Albuquerque, New Mexico Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 448 EP - 457 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 3 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Camps KW - Obesity KW - Measurement KW - Programs KW - Weight control KW - Pediatrics KW - Adolescence KW - Consultation KW - Validity KW - scoring KW - Lifestyle KW - Experience KW - Literature reviews KW - Social support KW - Family KW - Body concept KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Assessing+Weight-Related+Quality+of+Life+in+Adolescents&rft.au=Kolotkin%2C+Ronette+L%3BZeller%2C+Meg%3BModi%2C+Avani+C%3BSamsa%2C+Gregory+P%3BPolanichka+Quinlan%2C+Nicole%3BYanovski%2C+Jack+A%3BBell%2C+Stephen+K%3BMaahs%2C+David+M%3BGonzales+de+Serna%2C+Daniela%3BRoehrig%2C+Helmut+R&rft.aulast=Kolotkin&rft.aufirst=Ronette&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Camps; Measurement; Obesity; Programs; Weight control; Pediatrics; Consultation; Adolescence; Validity; Lifestyle; scoring; Experience; Social support; Literature reviews; Family; Body concept; Youth ER - TY - JOUR T1 - Cigarette Smoking and Lung Cancer: Modeling Total Exposure and Intensity AN - 17129101; 6752815 AB - Investigators typically analyze cigarette smoking using smoking duration and intensity (number of cigarettes smoked per day) as risk factors. However, odds ratios (OR) for categories of intensity either adjusted for, or jointly with, duration of smoking may be distorted by differences in total pack-years of exposure to cigarette smoke. To study effects of intensity, we apply a linear excess OR model to compare total exposure delivered at low intensity for a long period of time with an equal total exposure delivered at high intensity for a short period of time to data from a large case-control study of lung cancer. The excess OR per pack-year increases with intensity for subjects who smoke less than or equal to 20 cigarettes per day and decreases with intensity for subjects who smoke >20 cigarettes per day. The intensity patterns are homogeneous by histologic type of lung cancer, suggesting that observed differences in risks by histologic type are related to total smoking exposure or smoking duration and not smoking intensity. At lower smoking intensities, there is an "exposure enhancement" effect such that for equal total exposure, the excess OR per pack-year increases with intensity. At higher smoking intensities, there is a "reduced potency" or "wasted exposure" effect such that for equal total exposure, the excess OR per pack-year decreases with intensity (i.e., smoking at a lower intensity for longer duration is more deleterious than smoking at a higher intensity for shorter duration). (Cancer Epidemiol Biomarkers Prev 2006; 15(3):517-23) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Lubin, Jay H AU - Caporaso, Neil E AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 517 EP - 523 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 3 SN - 1055-9965, 1055-9965 KW - Toxicology Abstracts KW - Smoke KW - Mathematical models KW - Risk factors KW - Cigarette smoking KW - Cigarette smoke KW - biomarkers KW - Lung cancer KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17129101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Cigarette+Smoking+and+Lung+Cancer%3A+Modeling+Total+Exposure+and+Intensity&rft.au=Lubin%2C+Jay+H%3BCaporaso%2C+Neil+E&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2006-03-01&rft.volume=15&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoke; Mathematical models; Risk factors; Cigarette smoking; Cigarette smoke; biomarkers; Lung cancer ER - TY - JOUR T1 - Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene AN - 17126767; 6746665 AB - Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable with wild-type murine p53; however, transactivation, induction of apoptosis, and G sub(1)-S checkpoint, but not transrepression or regulation of a centrosomal checkpoint, were deregulated. Although multiple functions of p53 were abrogated, mice carrying the human p53 transgene did not show early onset of tumors as typically seen for p53-null mice. In contrast, human p53 in the p53-null background did not prevent accelerated tumor development after genotoxic or oncogenic stress. Such behavior of human p53 expressed at physiologic levels in transgenic cells could be explained by unexpectedly high binding with Mdm2. By using Nutlin-3a, an inhibitor of the interaction between Mdm2 and p53, we were able to partially reconstitute p53 transactivation and apoptosis in transgenic cells. Our findings indicate that the interaction between p53 and Mdm2 controls p53 transcriptional activity in homeostatic tissues and regulates DNA damage- and oncogene-induced, but not spontaneous, tumorigenesis.(Cancer Res 2006; 66(6): 2928-36) JF - Cancer Research AU - Dudgeon, Crissy AU - Kek, Calvina AU - Demidov, Oleg N AU - Saito, Shin-ichi AU - Fernandes, Kenneth AU - Diot, Alexandra AU - Bourdon, Jean-Christophe AU - Lane, David P AU - Appella, Ettore AU - Fornace, Albert JJr AU - Bulavin, Dmitry V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 2928 EP - 2936 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 6 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - MDM2 protein KW - Tumor suppressor genes KW - Apoptosis KW - Genotoxicity KW - Stress KW - Transcription KW - Tumors KW - Transgenic mice KW - p53 protein KW - DNA KW - W 30925:Genetic Engineering KW - B 26670:Tumor Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17126767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Tumor+Susceptibility+and+Apoptosis+Defect+in+a+Mouse+Strain+Expressing+a+Human+p53+Transgene&rft.au=Dudgeon%2C+Crissy%3BKek%2C+Calvina%3BDemidov%2C+Oleg+N%3BSaito%2C+Shin-ichi%3BFernandes%2C+Kenneth%3BDiot%2C+Alexandra%3BBourdon%2C+Jean-Christophe%3BLane%2C+David+P%3BAppella%2C+Ettore%3BFornace%2C+Albert+JJr%3BBulavin%2C+Dmitry+V&rft.aulast=Dudgeon&rft.aufirst=Crissy&rft.date=2006-03-01&rft.volume=66&rft.issue=6&rft.spage=2928&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - p53 protein; Apoptosis; MDM2 protein; Tumors; Transcription; Stress; Transgenic mice; DNA; Tumor suppressor genes; Genotoxicity ER - TY - JOUR T1 - Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state AN - 17121342; 6749332 AB - We have used a bioinformatic approach to predict the natural substrate proteins for the Escherichia coli chaperonin GroEL based on two simple criteria. Natural substrate proteins should contain binding motifs similar in sequence to the mobile loop peptide of GroES that displaces the binding motif during the chaperonin cycle. Secondly, each substrate protein should contain multiple copies of the binding motif so that the chaperonin can perform "work" on the substrate protein. To validate these criteria, we have used a database of 252 proteins that have been experimentally shown to interact with the chaperonin machinery in vivo. More than 80% are identified by these criteria. The binding motifs of all 79 proteins in the database with a known three-dimensional structure are buried (<50% solvent-accessible surface area) in the native state. Our results show that the binding motifs are inaccessible in the native state but become solvent-exposed in unfolded state, thus enabling GroEL to distinguish between unfolded and native states. The structures of the binding motif in the native states of the substrate proteins include alpha -helices, beta -strands, and random coils. The diversity of secondary structures implies that there are large and varied conformational transitions in the recognition motifs after their displacement by the mobile loops of GroES. JF - Proceedings of the National Academy of Sciences, USA AU - Stan, George AU - Brooks, Bernard R AU - Lorimer, George H AU - Thirumalai, D AD - Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 4433 EP - 4438 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 12 SN - 0027-8424, 0027-8424 KW - GroEL protein KW - Microbiology Abstracts B: Bacteriology KW - Protein structure KW - Databases KW - Surface area KW - Chaperonins KW - Secondary structure KW - Escherichia coli KW - Bioinformatics KW - Random coil KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17121342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Residues+in+substrate+proteins+that+interact+with+GroEL+in+the+capture+process+are+buried+in+the+native+state&rft.au=Stan%2C+George%3BBrooks%2C+Bernard+R%3BLorimer%2C+George+H%3BThirumalai%2C+D&rft.aulast=Stan&rft.aufirst=George&rft.date=2006-03-01&rft.volume=103&rft.issue=12&rft.spage=4433&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein structure; Databases; Surface area; Secondary structure; Chaperonins; Bioinformatics; Random coil; Escherichia coli ER - TY - JOUR T1 - Solution Structure of a Post-transition State Analog of the Phosphotransfer Reaction between the A and B Cytoplasmic Domains of the Mannitol Transporter II super(Mannitol) of the Escherichia coli Phosphotransferase System AN - 17113145; 6747791 AB - The solution structure of the post-transition state complex between the isolated cytoplasmic A (IIA super(Mtl)) and phosphorylated B (phospho-IIB super(Mtl)) domains of the mannitol transporter of the Escherichia coli phosphotransferase system has been solved by NMR. The active site His-554 of IIA super(Mtl) was mutated to glutamine to block phosphoryl transfer activity, and the active site Cys-384 of IIB super(Mtl) (residues of IIB super(Mtl) are denoted in italic type) was substituted by serine to permit the formation of a stable phosphorylated form of IIB super(Mtl). The two complementary interaction surfaces are predominantly hydrophobic, and two methionines on IIB super(Mtl), Met-388 and Met-393, serve as anchors by interacting with two deep pockets on the surface of IIA super(Mtl). With the exception of a salt bridge between the conserved Arg-538 of IIA super(Mtl) and the phosphoryl group of phospho-IIB super(Mtl), electrostatic interactions between the two proteins are limited to the outer edges of the interface, are few in number, and appear to be weak. This accounts for the low affinity of the complex (K sub(d) similar to 3.7 mM), which is optimally tuned to the intact biological system in which the A and B domains are expressed as a single polypeptide connected by a flexible 21-residue linker. The phosphoryl transition state can readily be modeled with no change in protein-protein orientation and minimal perturbations in both the backbone immediately adjacent to His-554 and Cys-384 and the side chains in close proximity to the phosphoryl group. Comparison with the previously solved structure of the IIA super(Mtl)-HPr complex reveals how IIA super(Mtl) uses the same interaction surface to recognize two structurally unrelated proteins and explains the much higher affinity of IIA super(Mtl) for HPr than IIB super(Mtl) JF - Journal of Biological Chemistry AU - Suh, Jeong-Yong AU - Cai, Mengli AU - Williams, David CJr AU - Clore, GMarius AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 8939 EP - 8949 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 13 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Salts KW - Glutamine KW - Mannitol KW - Escherichia coli KW - N.M.R. KW - Hydrophobicity KW - phosphotransferase KW - Serine KW - Methionine KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17113145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Solution+Structure+of+a+Post-transition+State+Analog+of+the+Phosphotransfer+Reaction+between+the+A+and+B+Cytoplasmic+Domains+of+the+Mannitol+Transporter+II+super%28Mannitol%29+of+the+Escherichia+coli+Phosphotransferase+System&rft.au=Suh%2C+Jeong-Yong%3BCai%2C+Mengli%3BWilliams%2C+David+CJr%3BClore%2C+GMarius&rft.aulast=Suh&rft.aufirst=Jeong-Yong&rft.date=2006-03-01&rft.volume=281&rft.issue=13&rft.spage=8939&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Salts; Glutamine; Mannitol; Hydrophobicity; N.M.R.; phosphotransferase; Methionine; Serine; Escherichia coli ER - TY - JOUR T1 - In Vitro Reconstitution of Catabolite Repression in Escherichia coli AN - 17112235; 6747509 AB - A widely accepted model for catabolite repression posits that phospho-IIA super(Glc) of the bacterial phosphotransferase system activates adenylyl cyclase (AC) activity. For many years, attempts to observe such regulatory properties of AC in vitro have been unsuccessful. To further study the regulation, AC was produced fused to the transmembrane segments of the serine chemoreceptor Tsr. Cells harboring Tsr-AC and normal AC, expressed from the cya promoter on a low copy number vector, exhibit similar behavior with respect to elevation of cAMP levels resulting from deletion of crp, expressing the catabolite regulatory protein. Membrane-bound Tsr-AC exhibits activity comparable with the native form of AC. Tsr-AC binds IIA super(Glc) specifically, regardless of its phosphorylation state, but not the two general phosphotransferase system proteins, enzyme I and HPr; IIA super(Glc) binding is localized to the C-terminal region of AC. Binding to membranes of either dephospho- or phospho-IIA super(Glc) has no effect on AC activity. However, in the presence of an Escherichia coli extract, P-IIA super(Glc), but not IIA super(Glc), stimulates AC activity. Based on these findings of a direct interaction of IIA super(Glc) with AC, but activity regulation only in the presence of E. coli extract, a revised model for AC activity regulation is proposed. JF - Journal of Biological Chemistry AU - Park, Young-Ha AU - Lee, Byeong R AU - Seok, Yeong-Jae AU - Peterkofsky, Alan AD - Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 151-742, Korea, the Department of Biology, Seowon University, Chongju City 361-742, Korea, and the Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-8017 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 6448 EP - 6454 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 10 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Chemoreceptors KW - Clonal deletion KW - Catabolites KW - Cyclic AMP KW - Enzyme I KW - phosphotransferase KW - copy number KW - Promoters KW - Gene deletion KW - regulatory proteins KW - Phosphorylation KW - Escherichia coli KW - Catabolite repression KW - Serine KW - Adenylate cyclase KW - J 02721:Cell cycle, morphology and motility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17112235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=In+Vitro+Reconstitution+of+Catabolite+Repression+in+Escherichia+coli&rft.au=Park%2C+Young-Ha%3BLee%2C+Byeong+R%3BSeok%2C+Yeong-Jae%3BPeterkofsky%2C+Alan&rft.aulast=Park&rft.aufirst=Young-Ha&rft.date=2006-03-01&rft.volume=281&rft.issue=10&rft.spage=6448&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemoreceptors; Clonal deletion; Catabolites; Cyclic AMP; Enzyme I; phosphotransferase; copy number; Promoters; Gene deletion; Phosphorylation; regulatory proteins; Catabolite repression; Serine; Adenylate cyclase; Escherichia coli ER - TY - JOUR T1 - A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection AN - 17107447; 6742383 AB - West Nile virus (WNV) is a neurotropic flavivirus within the Japanese encephalitis antigenic complex that is responsible for causing West Nile encephalitis in humans. The surface of WNV virions is covered by a highly ordered icosahedral array of envelope proteins that is responsible for mediating attachment and fusion with target cells. These envelope proteins are also primary targets for the generation of neutralizing antibodies in vivo. In this study, we describe a novel approach for measuring antibody-mediated neutralization of WNV infection using virus-like particles that measure infection as a function of reporter gene expression. These reporter virus particles (RVPs) are produced by complementation of a sub-genomic replicon with WNV structural proteins provided in trans using conventional DNA expression vectors. The precision and accuracy of this approach stem from an ability to measure the outcome of the interaction between antibody and viral antigens under conditions that satisfy the assumptions of the law of mass action as applied to virus neutralization. In addition to its quantitative strengths, this approach allows the production of WNV RVPs bearing the prM-E proteins of different WNV strains and mutants, offering considerable flexibility for the study of the humoral immune response to WNV in vitro. WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody. JF - Virology AU - Pierson, T C AU - Sanchez, MD AU - Puffer, BA AU - Ahmed, A A AU - Geiss, B J AU - Valentine, LE AU - Altamura, LA AU - Diamond AU - Doms, R W AD - University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, piersontc@mail.nih.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 53 EP - 65 VL - 346 IS - 1 SN - 0042-6822, 0042-6822 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Virions KW - Virology KW - Virus-like particles KW - Immunity KW - Infection KW - Flavivirus KW - Structural proteins KW - Encephalitis KW - Public health KW - Disease transmission KW - Expression vectors KW - Gene expression KW - Japanese encephalitis KW - Antibodies KW - Complementation KW - Antigens KW - Viral diseases KW - Reporter gene KW - Envelope protein KW - DNA KW - Immune response (humoral) KW - West Nile virus KW - Q1 08205:Genetics and evolution KW - V 22091:Immunological techniques & reagents KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17107447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=A+rapid+and+quantitative+assay+for+measuring+antibody-mediated+neutralization+of+West+Nile+virus+infection&rft.au=Pierson%2C+T+C%3BSanchez%2C+MD%3BPuffer%2C+BA%3BAhmed%2C+A+A%3BGeiss%2C+B+J%3BValentine%2C+LE%3BAltamura%2C+LA%3BDiamond%3BDoms%2C+R+W&rft.aulast=Pierson&rft.aufirst=T&rft.date=2006-03-01&rft.volume=346&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2005.10.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Virology; Gene expression; Antibodies; Antigens; Viral diseases; Immunity; Disease transmission; Public health; Virions; Virus-like particles; Infection; Encephalitis; Structural proteins; Expression vectors; Japanese encephalitis; Complementation; Reporter gene; Envelope protein; DNA; Immune response (humoral); West Nile virus; Flavivirus DO - http://dx.doi.org/10.1016/j.virol.2005.10.030 ER - TY - JOUR T1 - HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane AN - 17105899; 6742377 AB - We examined the association of HTLV-1 Gag with tetraspanin-enriched microdomains in the plasma membrane. Immunofluorescent staining and confocal image analysis showed that HTLV-1 Gag protein colocalized with CD82 and other tetraspanins at the plasma membrane of T cells. HTLV-1 Gag, which is associated with the inner surface of the plasma membrane, was concentrated to the patches formed by antibody-mediated cross-linking of CD82 on the cell surface. Also, CD82 and HTLV-1 Gag rapidly segregated to the immune synapse that is formed between Raji B cells and Jurkat T cells in the presence of bacterial superantigen. CD82, which was immunoprecipitated from cell extracts prepared in Brij97 detergent conditions, was associated with the matrix (MA) protein. Stable interaction of MA and CD82 in Brij97-disrupted cell extracts required Gag multimerization and proteolytic processing. The form of MA that coimmunoprecipitated with CD82 was a cysteine-linked homodimer. The viral envelope glycoprotein was not required for the association of Gag with CD82-enriched membrane regions. In contrast to HTLV-1, HIV-1 Gag did not colocalize, cosegregate, or coimmunoprecipitate with CD82. Our data suggest that once at the plasma membrane, HTLV-1 virion components associate with CD82-containing microdomains, which may facilitate the mobilization of nascent virions to sites of intercellular adhesion. JF - Virology AU - Mazurov, D AU - Heidecker, G AU - Derse, D AD - HIV Drug Resistance Program, Bld 535, Rm. 110, NCI-Frederick, Frederick, MD 21702-1201, USA, derse@ncifcrf.gov Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 194 EP - 204 VL - 346 IS - 1 SN - 0042-6822, 0042-6822 KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Proteolysis KW - Virions KW - Cell surface KW - Data processing KW - Detergents KW - Lymphocytes B KW - Human T-lymphotropic virus 1 KW - Image processing KW - Gag protein KW - Cell adhesion KW - Superantigens KW - Envelopes KW - Plasma membranes KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Glycoproteins KW - Immunological synapses KW - J 02330:Biochemistry KW - V 22042:Adsorption, penetration & uncoating UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17105899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=HTLV-1+Gag+protein+associates+with+CD82+tetraspanin+microdomains+at+the+plasma+membrane&rft.au=Mazurov%2C+D%3BHeidecker%2C+G%3BDerse%2C+D&rft.aulast=Mazurov&rft.aufirst=D&rft.date=2006-03-01&rft.volume=346&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2005.10.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Proteolysis; Cell surface; Data processing; Lymphocytes B; Detergents; Image processing; Gag protein; Cell adhesion; Superantigens; Envelopes; Plasma membranes; Lymphocytes T; Glycoproteins; Immunological synapses; Human immunodeficiency virus 1; Human T-lymphotropic virus 1 DO - http://dx.doi.org/10.1016/j.virol.2005.10.033 ER - TY - JOUR T1 - SMC complexes in bacterial chromosome condensation and segregation AN - 17092940; 6722040 AB - Bacterial chromosomes segregate via a partition apparatus that employs a score of specialized proteins. The SMC complexes play a crucial role in the chromosome partitioning process by organizing bacterial chromosomes through their ATP-dependent chromatin-compacting activity. Recent progress in the composition of these complexes and elucidation of their structural and enzymatic properties has advanced our comprehension of chromosome condensation and segregation mechanics in bacteria. egregation mechanics in bacteria. JF - Plasmid AU - Strunnikov, A V AD - NICHD, Bethesda, MD, USA, strunnik@mail.nih.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 135 EP - 144 PB - Elsevier Inc. VL - 55 IS - 2 SN - 0147-619X, 0147-619X KW - SMC protein KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Bacteria KW - Chromosomes KW - Condensation KW - Plasmids KW - G 07203:Plasmids KW - A 01300:Methods KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17092940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=SMC+complexes+in+bacterial+chromosome+condensation+and+segregation&rft.au=Strunnikov%2C+A+V&rft.aulast=Strunnikov&rft.aufirst=A&rft.date=2006-03-01&rft.volume=55&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2005.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; Condensation; Plasmids; Bacteria DO - http://dx.doi.org/10.1016/j.plasmid.2005.08.004 ER - TY - JOUR T1 - Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen AN - 17090834; 6725886 AB - Four single-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal factor (LF) of anthrax were isolated from a phage display library generated from immunized chimpanzees. Only 2 scFvs recognizing PA (Wl and W2) neutralized the cytotoxicity of lethal toxin in a macrophage lysis assay. Full-length immunoglobulin G (IgG) of W1 and W2 efficiently protected rats from anthrax toxin challenge. The epitope recognized by W1 and W2 was conformational and was formed by C-terminal amino acids 614-735 of PA. W1 and W2 each bound to PA with an equilibrium dissociation constant of 4 x 10 super(-11) mol/L to 5 x 10 super(-11) mol/L, which is an affinity that is 20-100-fold higher than that for the interaction of the receptor and PA. W1 and W2 inhibited the binding of PA to the receptor, suggesting that this was the mechanism of protection. These data suggest that W1 and W2 chimpanzee monoclonal antibodies may serve as PA entry inhibitors for use in the emergency prophylaxis against and treatment of anthrax. JF - Journal of Infectious Diseases AU - Chen, Z AU - Moayeri, M AU - Zhou, Y-H AU - Leppla, S AU - Emerson, S AU - Sebrell, A AU - Yu, F AU - Svitel, J AU - Schuck, P AU - Claire AU - Purcell, R AD - Hepatitis Viruses Section and Molecular Hepatitis Section, Laboratory of Infectious Diseases, and Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, and Protein Biophysics Resource, National Institutes of Health, Bethesda, and Bioqual, Rockville, Maryland, USA Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 625 EP - 633 VL - 193 IS - 5 SN - 0022-1899, 0022-1899 KW - Chimpanzee KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Amino acids KW - Data processing KW - Monoclonal antibodies KW - Lethal factor KW - Phage display KW - C-Terminus KW - protective antigen KW - Bacillus anthracis KW - Fv KW - Toxins KW - Pan troglodytes KW - Cytotoxicity KW - Prophylaxis KW - Immunoglobulin G KW - Anthrax KW - Epitopes KW - Amino acid sequence KW - J 02832:Antigenic properties and virulence KW - X 24370:Natural Toxins KW - F 06700:Monoclonal antibodies, hybridoma, antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17090834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Efficient+Neutralization+of+Anthrax+Toxin+by+Chimpanzee+Monoclonal+Antibodies+against+Protective+Antigen&rft.au=Chen%2C+Z%3BMoayeri%2C+M%3BZhou%2C+Y-H%3BLeppla%2C+S%3BEmerson%2C+S%3BSebrell%2C+A%3BYu%2C+F%3BSvitel%2C+J%3BSchuck%2C+P%3BClaire%3BPurcell%2C+R&rft.aulast=Chen&rft.aufirst=Z&rft.date=2006-03-01&rft.volume=193&rft.issue=5&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Data processing; Amino acids; Monoclonal antibodies; Lethal factor; protective antigen; C-Terminus; Phage display; Toxins; Fv; Cytotoxicity; Immunoglobulin G; Prophylaxis; Anthrax; Epitopes; Amino acid sequence; Bacillus anthracis; Pan troglodytes ER - TY - JOUR T1 - Effective Dosing of Lipid A Analogue E5564 in Rats Depends on the Timing of Treatment and the Route of Escherichia coli Infection AN - 17090326; 6725887 AB - Background. E5564, a competitive lipid A antagonist, inhibits endotoxin-stimulated inflammation and is under study in patients with sepsis. Methods. We tested whether clinically relevant variables, including the timing of treatment and the route of infection, influenced the effective dosing of E5564 in Escherichia coli-challenged rats. Results. All E5564 doses (0.3, 1.0, 2.0, and 3.0 mg/kg intravascular bolus followed by 10% of the bolus dose infused hourly for 24 h) administered 1 h before intravascular E. coli challenge similarly reduced the risk of death. Delaying the start of E5564 to 1 or 3 h after intravascular E. coli challenge significantly reduced the beneficial effect of the doses tested. However, increasing the dose of E5564 reversed some loss of efficacy for delayed treatment (P = .004, for increasing benefit with increasing dose at 1 h). During intrabronchial or intraperitoneal (extravascular) E. coli challenge, the pattern of effective E5564 dosing was the inverse of that for intravascular E. coli challenge (P = .001, for the interaction)-- lower doses of E5564 were beneficial and higher doses were not (0.03, 0.3, 1.0, 2.0, and 3.0 mg/kg bolus followed by infusion) (P = .05, for decreasing benefit with increasing dose at 1 h). Conclusion. These findings suggest that, for maximal clinical benefit, E5564 should be given early and that dosing should be adjusted upward for intravascular infection and downward for extravascular infection. JF - Journal of Infectious Diseases AU - Solomon, S B AU - Cui, X AU - Gerstenberger, E AU - Danner, R L AU - Fitz, Y AU - Banks, S M AU - Natanson, C AU - Eichacker, P Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 634 EP - 644 VL - 193 IS - 5 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Sepsis KW - Escherichia coli KW - Lipid A KW - Inflammation KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17090326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Effective+Dosing+of+Lipid+A+Analogue+E5564+in+Rats+Depends+on+the+Timing+of+Treatment+and+the+Route+of+Escherichia+coli+Infection&rft.au=Solomon%2C+S+B%3BCui%2C+X%3BGerstenberger%2C+E%3BDanner%2C+R+L%3BFitz%2C+Y%3BBanks%2C+S+M%3BNatanson%2C+C%3BEichacker%2C+P+Q&rft.aulast=Solomon&rft.aufirst=S&rft.date=2006-03-01&rft.volume=193&rft.issue=5&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Sepsis; Lipid A; Inflammation; Escherichia coli ER - TY - JOUR T1 - Preclinical Perspectives on Garlic and Cancer AN - 17089327; 6714683 AB - Evidence continues to point to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds generated by processing garlic. These anticarcinogenic and antitumorigenic characteristics appear to arise through both dose- and temporal-related changes in a number of cellular events involved with the cancer process, including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis, and angiogenesis. The ability of garlic and related allyl sulfur compounds to block tumors in the colon, lung, breast, and liver suggests general mechanisms that are not tissue specific. Whereas relatively few studies have compared the relative efficacy of water- and lipid-soluble allyl sulfur compounds, those that have when using chemically induced carcinogen models suggest little difference in response, whereas tumor proliferation/apoptosis is highly dependent on the species provided. A shift in sulfhydryl groups, alterations in glutathione:oxidized glutathione ratios, and resultant changes in cellular redox status may be involved in some of the phenotypic changes caused by allyl sulfur compounds. Such changes in thiols by allyl sulfurs may also account for the observed hyperphosphorylation of specific cell cycle proteins and the histone hyperacetylation that has been correlated with suppressed tumor cell proliferation. Whereas the anticarcinogenic and antitumorigenic data to date are impressive, additional studies are needed with more modest exposure to allyl sulfur compounds over prolonged periods. Likewise, additional studies are needed that incorporate transgenic and knockout models to assist in the identification of molecular targets for garlic and its associated allyl sulfur components. JF - Journal of Nutrition AU - Milner, John A AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20854 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 827S EP - 831S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 3 SN - 0022-3166, 0022-3166 KW - garlic KW - Risk Abstracts KW - Diets KW - Allium sativum KW - Liver KW - Proteins KW - Risk reduction KW - Nutrition KW - Cancer KW - Metabolism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17089327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Preclinical+Perspectives+on+Garlic+and+Cancer&rft.au=Milner%2C+John+A&rft.aulast=Milner&rft.aufirst=John&rft.date=2006-03-01&rft.volume=136&rft.issue=3&rft.spage=827S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Liver; Proteins; Risk reduction; Nutrition; Metabolism; Cancer; Allium sativum ER - TY - JOUR T1 - Effects of Lipid Formulations of Amphotericin B on Activity of Human Monocytes against Aspergillus fumigatus AN - 17087977; 6715631 AB - The immunomodulatory effects of liposomal amphotericin B (LAMB), amphotericin B lipid complex, and amphotericin B colloidal dispersion (ABCD) on antifungal activity of human monocytes (MNCs), an important component of antifungal host defense, against Aspergillus fumigatus were compared to those of deoxycholate amphotericin B (DAMB). MNCs from healthy volunteers were incubated with 1 or 5 mu g/ml DAMB and 5 or 25 mu g/ml lipid formulations for 22 h. Drug-pretreated or untreated MNCs were then washed and assayed for the following: (i) activity against A. fumigatus hyphae by XTT assay at MNC:hypha ratios of 10:1 and 20:1; (ii) production of superoxide anion (O sub(2) super(-)) from MNCs in response to hyphae by cytochrome c reduction; (iii) production of hydrogen peroxide (H sub(2)O sub(2)) and H sub(2)O sub(2)-dependent intracellular intermediates (DIIs), such as OH super(-) and HOCl, from MNCs in response to A. fumigatus culture supernatant by flow cytometric measurement of dihydrorhodamine-1,2,3 oxidation. With the exception of 1 mu g/ml DAMB and 5 mu g/ml LAMB or ABCD at 10:1, all amphotericin B formulations at both concentrations and MNC:hypha ratios enhanced MNC-induced damage of A. fumigatus hyphae compared to results with untreated cells (P < 0.01). While MNC O sub(2) super(-) production upon hyphal challenge, an early event in oxidative burst, was not affected by the drugs, production of H sub(2)O sub(2) and DIIs, late events, were significantly increased by all four drugs (P < 0.01). At clinically relevant concentrations, both conventional amphotericin B and its lipid formulations enhance antihyphal activity of MNCs against A. fumigatus in association with significant augmentation of H sub(2)O sub(2) and DIIs but not O sub(2) super(-), further demonstrating the immunomodulatory antifungal activities of these agents. JF - Antimicrobial Agents & Chemotherapy AU - Dotis, J AU - Simitsopoulou, M AU - Dalakiouridou, M AU - Konstantinou, T AU - Taparkou, A AU - Kanakoudi-Tsakalidou, F AU - Walsh, T J AU - Roilides, E AD - Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece. Laboratory of Clinical Immunology, 1st Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 868 EP - 873 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amphotericin B KW - Lipids KW - Hyphae KW - Cell culture KW - Antimicrobial agents KW - Cytochrome c KW - Hydrogen peroxide KW - Aspergillus fumigatus KW - Antifungal activity KW - Oxidation KW - superoxide anions KW - Monocytes KW - Drugs KW - A 01067:Antifungal & fungicidal KW - K 03063:Effects of physical & chemical factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effects+of+Lipid+Formulations+of+Amphotericin+B+on+Activity+of+Human+Monocytes+against+Aspergillus+fumigatus&rft.au=Dotis%2C+J%3BSimitsopoulou%2C+M%3BDalakiouridou%2C+M%3BKonstantinou%2C+T%3BTaparkou%2C+A%3BKanakoudi-Tsakalidou%2C+F%3BWalsh%2C+T+J%3BRoilides%2C+E&rft.aulast=Dotis&rft.aufirst=J&rft.date=2006-03-01&rft.volume=50&rft.issue=3&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Cytochrome c; Hydrogen peroxide; Lipids; Oxidation; Antifungal activity; Hyphae; superoxide anions; Cell culture; Monocytes; Drugs; Antimicrobial agents; Aspergillus fumigatus ER - TY - JOUR T1 - Human Immunodeficiency Virus (HIV) Vaccine Trials: a Novel Assay for Differential Diagnosis of HIV Infections in the Face of Vaccine-Generated Antibodies AN - 17087780; 6714736 AB - All current human immunodeficiency virus (HIV) vaccine candidates contain multiple viral components and elicit antibodies that react positively in licensed HIV diagnostic tests, which contain similar viral products. Thus, vaccine trial participants could be falsely diagnosed as infected with HIV. Additionally, uninfected, seropositive vaccinees may encounter long-term social and economic harms. Moreover, this also interferes with early detection of true HIV infections during preventive HIV vaccine trials. An HIV-seropositive test result among uninfected vaccine trial participants is a major public health concern for volunteers who want to participate in future HIV vaccine trials. Based on the increased number of HIV vaccines being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Using a whole-HIV-genome phage display library, we identified conserved sequences in Env-gp41 and Gag-p6 which are recognized soon after infection, do not contain protective epitopes, and are not part of most current HIV vaccines. We established a new HIV serodetection assay based on these peptides. To date, this assay, termed HIV-SELECTEST, demonstrates >99% specificity and sensitivity. Importantly, in testing of plasma samples from multiple HIV vaccine trials, uninfected trial participants scored negative, while all intercurrent infections were detected within 1 to 3 months of HIV infection. The new HIV-SELECTEST is a simple but robust diagnostic tool for easy implementation in HIV vaccine trials and blood banks worldwide. JF - Journal of Virology AU - Khurana, Surender AU - Needham, James AU - Mathieson, Bonnie AU - Rodriguez-Chavez, Isaac R AU - Catanzaro, Andrew T AU - Bailer, Robert T AU - Kim, Jerome AU - Polonis, Vicky AU - Cooper, David A AU - Guerin, Jan AU - Peterson, Michael L AU - Gurwith, Marc AU - Nguyen, Nga AU - Graham, Barney S AU - Golding, Hana AD - Division of Viral Products. Core Facility, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, Maryland 20892. Office of AIDS Research, NIH, Bethesda, Maryland 20892. Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892. U.S. Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), APO AP 96546. U.S. Military HIV Research Program, Rockville, Maryland 20850. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia 2010. VaxGen, Inc., Brisbane, California 94005 Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 2092 EP - 2099 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 5 SN - 0022-538X, 0022-538X KW - HIV KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Public health KW - Economics KW - Epitopes KW - Phage display KW - Blood KW - Antibodies KW - Differential diagnosis KW - Human immunodeficiency virus KW - Vaccines KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - V 22003:AIDS: Immunological aspects KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Human+Immunodeficiency+Virus+%28HIV%29+Vaccine+Trials%3A+a+Novel+Assay+for+Differential+Diagnosis+of+HIV+Infections+in+the+Face+of+Vaccine-Generated+Antibodies&rft.au=Khurana%2C+Surender%3BNeedham%2C+James%3BMathieson%2C+Bonnie%3BRodriguez-Chavez%2C+Isaac+R%3BCatanzaro%2C+Andrew+T%3BBailer%2C+Robert+T%3BKim%2C+Jerome%3BPolonis%2C+Vicky%3BCooper%2C+David+A%3BGuerin%2C+Jan%3BPeterson%2C+Michael+L%3BGurwith%2C+Marc%3BNguyen%2C+Nga%3BGraham%2C+Barney+S%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2006-03-01&rft.volume=80&rft.issue=5&rft.spage=2092&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Vaccines; Antibodies; Public health; Phage display; Blood; Economics; Differential diagnosis; Epitopes ER - TY - JOUR T1 - A Single Intranasal Inoculation with a Paramyxovirus-Vectored Vaccine Protects Guinea Pigs against a Lethal-Dose Ebola Virus Challenge AN - 17087609; 6714753 AB - To determine whether intranasal inoculation with a paramyxovirus-vectored vaccine can induce protective immunity against Ebola virus (EV), recombinant human parainfluenza virus type 3 (HPIV3) was modified to express either the EV structural glycoprotein (GP) by itself (HPIV3/EboGP) or together with the EV nucleoprotein (NP) (HPIV3/EboGP-NP). Expression of EV GP by these recombinant viruses resulted in its efficient incorporation into virus particles and increased cytopathic effect in Vero cells. HPIV3/EboGP was 100-fold more efficiently neutralized by antibodies to EV than by antibodies to HPIV3. Guinea pigs infected with a single intranasal inoculation of 10 super(5.3) PFU of HPIV3/EboGP or HPIV3/EboGP-NP showed no apparent signs of disease yet developed a strong humoral response specific to the EV proteins. When these animals were challenged with an intraperitoneal injection of 10 super(3) PFU of EV, there were no outward signs of disease, no viremia or detectable EV antigen in the blood, and no evidence of infection in the spleen, liver, and lungs. In contrast, all of the control animals died or developed severe EV disease following challenge. The highly effective immunity achieved with a single vaccine dose suggests that intranasal immunization with live vectored vaccines based on recombinant respiratory viruses may be an advantageous approach to inducing protective responses against severe systemic infections, such as those caused by hemorrhagic fever agents. JF - Journal of Virology AU - Bukreyev, Alexander AU - Yang, Lijuan AU - Zaki, Sherif R AU - Shieh, Wun-Ju AU - Rollin, Pierre E AU - Murphy, Brian R AU - Collins, Peter L AU - Sanchez, Anthony AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2006/03/01/ PY - 2006 DA - 2006 Mar 01 SP - 2267 EP - 2279 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 5 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Disseminated infection KW - Nucleoproteins KW - Ebola virus KW - Parainfluenza KW - Parainfluenza virus KW - Glycoproteins KW - Vero cells KW - Spleen KW - Paramyxovirus KW - Immunity KW - Antibody response KW - Blood KW - Hemorrhagic fever KW - Viremia KW - Vaccines KW - W3 33365:Vaccines (other) KW - V 22097:Immunization: Vaccines & vaccination: Human KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17087609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A+Single+Intranasal+Inoculation+with+a+Paramyxovirus-Vectored+Vaccine+Protects+Guinea+Pigs+against+a+Lethal-Dose+Ebola+Virus+Challenge&rft.au=Bukreyev%2C+Alexander%3BYang%2C+Lijuan%3BZaki%2C+Sherif+R%3BShieh%2C+Wun-Ju%3BRollin%2C+Pierre+E%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L%3BSanchez%2C+Anthony&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2006-03-01&rft.volume=80&rft.issue=5&rft.spage=2267&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ebola virus; Parainfluenza virus; Paramyxovirus; Vaccines; Antibody response; Immunity; Hemorrhagic fever; Blood; Parainfluenza; Vero cells; Viremia; Spleen; Glycoproteins; Nucleoproteins; Disseminated infection ER - TY - JOUR T1 - Delta super(9)-Tetrahydrocannabinol and Endogenous Cannabinoid Anandamide Directly Potentiate the Function of Glycine Receptors AN - 17086411; 6714886 AB - Anandamide (AEA) and Delta super(9)-tetrahydrocannabinol (THC) are endogenous and exogenous ligands, respectively, for cannabinoid receptors. Whereas most of the pharmacological actions of cannabinoids are mediated by CB1 receptors, there is also evidence that these compounds can produce effects that are not mediated by the activation of identified cannabinoid receptors. Here, we report that THC and AEA, in a CB1 receptor-independent manner, cause a significant potentiation of the amplitudes of glycine-activated currents (I sub(Gly)) in acutely isolated neurons from rat ventral tegmental area (VTA) and in Xenopus laevis oocytes expressing human homomeric ( alpha 1) and heteromeric ( alpha 1 beta 1) subunits of glycine receptors (GlyRs). The potentiation of I sub(Gly) by THC and AEA is concentration-dependent, with respective EC sub(50) values of 86 plus or minus 9 and 319 plus or minus 31 nM for alpha 1 homomeric receptors, 73 plus or minus 8 and 318 plus or minus 24 nM for alpha 1 beta 1 heteromeric receptors, and 115 plus or minus 13 and 230 plus or minus 29 nM for native GlyRs in VTA neurons. The effects of THC and AEA are selective for I sub(Gly), because GABA-activated current in VTA neurons or in X. laevis oocytes expressing alpha 2 beta 3 gamma 2 GABA sub(A) receptor subunits were unaffected by these compounds. The maximal potentiation by THC and AEA was observed at the lowest concentration of glycine; with increasing concentrations of glycine, the potentiation significantly decreased. The site for THC and AEA seems to be distinct from that of the alcohol and volatile anesthetics. The results indicate that THC and AEA, in pharmacologically relevant concentrations, directly potentiate the function of GlyRs through an allosteric mechanism. JF - Molecular Pharmacology AU - Hejazi, Nadia AU - Zhou, Chunyi AU - Oz, Murat AU - Sun, Hui AU - Ye, Jiang Hong AU - Zhang, Li AD - Laboratory of Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland (N.H., H.S., L.Z.) Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 991 EP - 997 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 69 IS - 3 SN - 0026-895X, 0026-895X KW - African clawed frog KW - Toxicology Abstracts KW - Anandamide KW - Glycine receptors KW - Anesthetics KW - Ventral tegmentum KW - Tetrahydrocannabinol KW - Xenopus laevis KW - Volatiles KW - Neurons KW - Allosteric properties KW - gamma -Aminobutyric acid A receptors KW - alcohols KW - Oocytes KW - Cannabinoid CB1 receptors KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17086411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Delta+super%289%29-Tetrahydrocannabinol+and+Endogenous+Cannabinoid+Anandamide+Directly+Potentiate+the+Function+of+Glycine+Receptors&rft.au=Hejazi%2C+Nadia%3BZhou%2C+Chunyi%3BOz%2C+Murat%3BSun%2C+Hui%3BYe%2C+Jiang+Hong%3BZhang%2C+Li&rft.aulast=Hejazi&rft.aufirst=Nadia&rft.date=2006-03-01&rft.volume=69&rft.issue=3&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Tetrahydrocannabinol; Anandamide; Volatiles; Allosteric properties; Neurons; gamma -Aminobutyric acid A receptors; alcohols; Glycine receptors; Ventral tegmentum; Anesthetics; Oocytes; Cannabinoid CB1 receptors; Xenopus laevis ER - TY - JOUR T1 - Pertussis toxin as an adjuvant suppresses the number and function of CD4 super(+)CD25 super(+) T regulatory cells AN - 17082458; 6707379 AB - We observed a remarkable reduction in the frequency and immunosuppressive activity of splenic CD4 super(+)CD25 super(+) T cells in C57BL/6 mice with MOG sub(33-55)- induced experimental autoimmune encephalomyelitis (EAE). Our study revealed that pertussis toxin (PTx), one component of the immunogen used to induce murine EAE, was responsible for down-regulating splenic CD4 super(+)CD25 super(+) cells. Treatment of normal BALB/c mice with PTx in vivo reduced the frequency, suppressive activity and FoxP3 expression by splenic CD4 super(+)CD25 super(+) T cells. However, PTx treatment did not alter the expression of characteristic phenotypic markers (CD45RB, CD103, GITR and CTLA-4) and did not increase the expression of CD44 and CD69 by the residual splenic and lymph node CD4 super(+)CD25 super(+) T cells. This property of PTx was attributable to its ADP-ribosyltransferase activity. PTx did not inhibit suppressive activity of purified CD4 super(+)CD25 super(+) T regulatory (Treg) cells in vitro, but did so in vivo, presumably due to an indirect effect. Although the exact molecular target of PTx that reduces Treg activity remains to be defined, our data suggests that alteration of both distribution and function of splenic immunocytes should play a role. This study concludes that an underlying cause for the immunological adjuvanticity of PTx is down- regulation of Treg cell number and function. JF - European Journal of Immunology AU - Chen, Xin AU - Winkler-Pickett, Robin T AU - Carbonetti, Nicholas H AU - Ortaldo, John R AU - Oppenheim, Joost J AU - Howard, OMZack AD - Basic Research Program, SAIC-Frederick, Inc., Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick. Frederick, MD, USA, xinc@mail.ncifcrf.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 671 EP - 680 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 36 IS - 3 SN - 0014-2980, 0014-2980 KW - Toxicology Abstracts; Immunology Abstracts KW - CD4 super(+)CD25 super(+) T regulatory cells Experimental autoimmune encephalomyelitis Pertussis toxin KW - CD69 antigen KW - Immunoregulation KW - CD45RB antigen KW - Data processing KW - Cell number KW - CTLA-4 protein KW - NAD(P) super(+)-arginine ADP-ribosyltransferase KW - CD44 antigen KW - Spleen KW - Adjuvants KW - CD25 antigen KW - Immunosuppressive agents KW - Lymph nodes KW - pertussis toxin KW - Bordetella pertussis KW - Adjuvanticity KW - CD103 antigen KW - CD4 antigen KW - Foxp3 protein KW - Lymphocytes T KW - Experimental allergic encephalomyelitis KW - X 24310:Pharmaceuticals KW - F 06324:Multiple Sclerosis: Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17082458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=Pertussis+toxin+as+an+adjuvant+suppresses+the+number+and+function+of+CD4+super%28%2B%29CD25+super%28%2B%29+T+regulatory+cells&rft.au=Chen%2C+Xin%3BWinkler-Pickett%2C+Robin+T%3BCarbonetti%2C+Nicholas+H%3BOrtaldo%2C+John+R%3BOppenheim%2C+Joost+J%3BHoward%2C+OMZack&rft.aulast=Chen&rft.aufirst=Xin&rft.date=2006-03-01&rft.volume=36&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200535353 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - CD69 antigen; Immunoregulation; CD45RB antigen; Data processing; Cell number; NAD(P) super(+)-arginine ADP-ribosyltransferase; CTLA-4 protein; CD44 antigen; Spleen; Adjuvants; CD25 antigen; Immunosuppressive agents; Lymph nodes; pertussis toxin; CD4 antigen; CD103 antigen; Adjuvanticity; Foxp3 protein; Lymphocytes T; Experimental allergic encephalomyelitis; Bordetella pertussis DO - http://dx.doi.org/10.1002/eji.200535353 ER - TY - JOUR T1 - Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: a multisite effectiveness study. AN - 70730545; 16169159 AB - Despite recent emphasis on integrating empirically validated treatment into clinical practice, there are little data on whether manual-guided behavioral therapies can be implemented in standard clinical practice and whether incorporation of such techniques is associated with improved outcomes. The effectiveness of integrating motivational interviewing (MI) techniques into the initial contact and evaluation session was evaluated in a multisite randomized clinical trial. Participants were 423 substance users entering outpatient treatment in five community-based treatment settings, who were randomized to receive either the standard intake/evaluation session at each site or the same session in which MI techniques and strategies were integrated. Clinicians were drawn from the staff of the participating programs and were randomized either to learn and implement MI or to deliver the standard intake/evaluation session. Independent analyses of 315 session audiotapes suggested the two forms of treatment were highly discriminable and that clinicians trained to implement MI tended to have higher skill ratings. Regarding outcomes, for the sample as a whole, participants assigned to MI had significantly better retention through the 28-day follow-up than those assigned to the standard intervention. There were no significant effects of MI on substance use outcomes at either the 28-day or 84-day follow-up. Results suggest that community-based clinicians can effectively implement MI when provided training and supervision, and that integrating MI techniques in the earliest phases of treatment may have positive effects on retention early in the course of treatment. JF - Drug and alcohol dependence AU - Carroll, Kathleen M AU - Ball, Samuel A AU - Nich, Charla AU - Martino, Steve AU - Frankforter, Tami L AU - Farentinos, Christiane AU - Kunkel, Lynn E AU - Mikulich-Gilbertson, Susan K AU - Morgenstern, Jon AU - Obert, Jeanne L AU - Polcin, Doug AU - Snead, Ned AU - Woody, George E AU - National Institute on Drug Abuse Clinical Trials Network AD - Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA. kathleen.carroll@yale.edu ; National Institute on Drug Abuse Clinical Trials Network Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 SP - 301 EP - 312 VL - 81 IS - 3 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Female KW - Patient Compliance -- statistics & numerical data KW - Interview, Psychological KW - Motivation KW - Patient Acceptance of Health Care KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70730545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Motivational+interviewing+to+improve+treatment+engagement+and+outcome+in+individuals+seeking+treatment+for+substance+abuse%3A+a+multisite+effectiveness+study.&rft.au=Carroll%2C+Kathleen+M%3BBall%2C+Samuel+A%3BNich%2C+Charla%3BMartino%2C+Steve%3BFrankforter%2C+Tami+L%3BFarentinos%2C+Christiane%3BKunkel%2C+Lynn+E%3BMikulich-Gilbertson%2C+Susan+K%3BMorgenstern%2C+Jon%3BObert%2C+Jeanne+L%3BPolcin%2C+Doug%3BSnead%2C+Ned%3BWoody%2C+George+E%3BNational+Institute+on+Drug+Abuse+Clinical+Trials+Network&rft.aulast=Carroll&rft.aufirst=Kathleen&rft.date=2006-02-28&rft.volume=81&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2003 Oct;71(5):843-61 [14516234] Addiction. 2004 Jan;99(1):39-52 [14678061] J Subst Abuse Treat. 2003 Sep;25(2):117-21 [14680015] Drug Alcohol Depend. 2004 Jan 7;73(1):99-106 [14687964] J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] AIDS. 1991 Feb;5(2):181-5 [2031690] J Subst Abuse. 1990;2(2):217-35 [2136111] Br J Addict. 1992 Jul;87(7):1013-24 [1322747] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] Drug Alcohol Depend. 1994 Feb;34(3):201-9 [8033757] Drug Alcohol Depend. 1994 Apr;35(2):127-32 [8055734] J Consult Clin Psychol. 1994 Aug;62(4):843-50 [7962889] J Stud Alcohol Suppl. 1994 Dec;12:112-8 [7722987] J Stud Alcohol Suppl. 1994 Dec;12:70-5 [7723001] J Stud Alcohol. 1997 Jan;58(1):7-29 [8979210] J Clin Psychol. 1998 Apr;54(3):297-301 [9545167] J Stud Alcohol. 2000 Jan;61(1):55-63 [10627097] Drug Alcohol Depend. 2000 Jan 1;57(3):225-38 [10661673] J Consult Clin Psychol. 2000 Feb;68(1):134-44 [10710848] Psychol Addict Behav. 2001 Jun;15(2):159-62 [11419233] Addiction. 2001 Aug;96(8):1149-60 [11487421] J Consult Clin Psychol. 2001 Dec;69(6):1007-17 [11777104] Addiction. 2001 Dec;96(12):1725-42 [11784466] Addiction. 2002 Mar;97(3):265-77 [11964100] J Subst Abuse Treat. 2002 Sep;23(2):73-80 [12220604] J Subst Abuse Treat. 2002 Dec;23(4):309-18 [12495792] Psychiatr Serv. 2003 Mar;54(3):333-9 [12610240] Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] J Consult Clin Psychol. 2003 Aug;71(4):754-63 [12924680] J Consult Clin Psychol. 1998 Apr;66(2):290-303 [9583332] Drug Alcohol Depend. 1998 Aug 1;51(3):253-63; discussion 267-8 [9787998] J Consult Clin Psychol. 1999 Feb;67(1):37-42 [10028207] J Consult Clin Psychol. 2004 Dec;72(6):1050-62 [15612851] Psychol Bull. 1979 Mar;86(2):420-8 [18839484] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. AN - 67724611; 16520553 AB - Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and apigenin suppressed PMA-induced PLD activation in a dose-dependent manner as well as basal PLD activity, suggesting the involvement of CKII in the activation of both PLD1 and PLD2. CKII was associated with PLD1 and PLD2 in co-transfection experiments. Furthermore, CKII induced serine/threonine phosphorylation of PLD2 in vivo, and the multiple regions of PLD2 were phosphorylated by CKII in vitro kinase assay using glutathione S-transferase-PLD2 fusion protein fragments. Elevated expression of CKII or PLD increased cell proliferation but pretreatment of cells with 1-butanol suppressed CKII-induced cell proliferation. These results suggest that CKII is involved in proliferation of U87 cells at least in part, through stimulation of PLD activity. JF - Experimental & molecular medicine AU - Ahn, Bong-Hyun AU - Min, Gyesik AU - Bae, Yoe-Sik AU - Bae, Young-Seuk AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute (NHLBI), NIH Bldg 10/CRC 5-3288, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 SP - 55 EP - 62 VL - 38 IS - 1 SN - 1226-3613, 1226-3613 KW - Enzyme Inhibitors KW - 0 KW - Recombinant Fusion Proteins KW - 1-Butanol KW - 8PJ61P6TS3 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Casein Kinase II KW - EC 2.7.11.1 KW - Phospholipase D KW - EC 3.1.4.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - 1-Butanol -- pharmacology KW - Cell Proliferation -- drug effects KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Humans KW - Glutathione Transferase -- metabolism KW - Cell Line, Tumor KW - Precipitin Tests KW - Phosphorylation -- drug effects KW - Recombinant Fusion Proteins -- metabolism KW - Blotting, Western KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Phospholipase D -- metabolism KW - Casein Kinase II -- analysis KW - Astrocytoma -- enzymology KW - Phospholipase D -- genetics KW - Casein Kinase II -- pharmacology KW - Astrocytoma -- pathology KW - Astrocytoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67724611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+%26+molecular+medicine&rft.atitle=Phospholipase+D+is+activated+and+phosphorylated+by+casein+kinase-II+in+human+U87+astroglioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BMin%2C+Gyesik%3BBae%2C+Yoe-Sik%3BBae%2C+Young-Seuk%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2006-02-28&rft.volume=38&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Experimental+%26+molecular+medicine&rft.issn=12263613&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Structures of the Essential Mosquito-Stage Protein P25 and its Complex with a Transmission-Blocking Antibody T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39942297; 4143219 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Garboczi, David Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Antibodies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39942297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Structures+of+the+Essential+Mosquito-Stage+Protein+P25+and+its+Complex+with+a+Transmission-Blocking+Antibody&rft.au=Garboczi%2C+David&rft.aulast=Garboczi&rft.aufirst=David&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population Structure and Evolution in P. falciparum T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39933528; 4143224 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Su, Xin-Zhuan Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Population structure KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Population+Structure+and+Evolution+in+P.+falciparum&rft.au=Su%2C+Xin-Zhuan&rft.aulast=Su&rft.aufirst=Xin-Zhuan&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Responses to Malaria Vaccine Candidates T2 - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AN - 39892884; 4143232 JF - 2006 Keystone Symposia on Malaria: Functional Genomics to Biology to Medicine (C5) AU - Long, Carole A Y1 - 2006/02/28/ PY - 2006 DA - 2006 Feb 28 KW - Vaccines KW - Malaria KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.atitle=Immune+Responses+to+Malaria+Vaccine+Candidates&rft.au=Long%2C+Carole+A&rft.aulast=Long&rft.aufirst=Carole&rft.date=2006-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Malaria%3A+Functional+Genomics+to+Biology+to+Medicine+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=804&sub Tab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combinatorial Vaccine Strategies T2 - 2006 Conference of the Sidney Kimmel Cancer Center AN - 39930509; 4161750 JF - 2006 Conference of the Sidney Kimmel Cancer Center AU - Schlom, Jeffrey Y1 - 2006/02/27/ PY - 2006 DA - 2006 Feb 27 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Sidney+Kimmel+Cancer+Center&rft.atitle=Combinatorial+Vaccine+Strategies&rft.au=Schlom%2C+Jeffrey&rft.aulast=Schlom&rft.aufirst=Jeffrey&rft.date=2006-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Sidney+Kimmel+Cancer+Center&rft.issn=&rft_id=info:doi/ L2 - http://skcc.org/SKCC_conf_program_06.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ebola Virus Immunity T2 - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AN - 40140288; 4099028 JF - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AU - Sullivan, Nancy J Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Immunity KW - Ebola virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40140288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.atitle=Ebola+Virus+Immunity&rft.au=Sullivan%2C+Nancy+J&rft.aulast=Sullivan&rft.aufirst=Nancy&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins T2 - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AN - 40116965; 4098995 JF - 2006 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (C4) AU - Blumenthal, Robert P Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Glycoproteins KW - Envelopes KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40116965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.atitle=Conformational+Changes+and+Fusion+Activity+of+HIV+Envelope+Glycoproteins&rft.au=Blumenthal%2C+Robert+P&rft.aulast=Blumenthal&rft.aufirst=Robert&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ty1 Suicide: Formation of LTR Joint Molecules and Autointegration T2 - 2006 Conference of the American Society for Microbiology on Mobile DNA AN - 39979561; 4159276 JF - 2006 Conference of the American Society for Microbiology on Mobile DNA AU - Garfinkel, David J Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Suicide KW - Joints UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39979561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.atitle=Ty1+Suicide%3A+Formation+of+LTR+Joint+Molecules+and+Autointegration&rft.au=Garfinkel%2C+David+J&rft.aulast=Garfinkel&rft.aufirst=David&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.issn=&rft_id=info:doi/ L2 - http://www.asm.org/Meetings/index.asp?bid=37149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The LTR-Retrotransposon Tf1 Integrates Specifically into the Promoters of Pol II Transcribed Genes T2 - 2006 Conference of the American Society for Microbiology on Mobile DNA AN - 39878787; 4159289 JF - 2006 Conference of the American Society for Microbiology on Mobile DNA AU - Levin, Henry Y1 - 2006/02/24/ PY - 2006 DA - 2006 Feb 24 KW - Promoters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.atitle=The+LTR-Retrotransposon+Tf1+Integrates+Specifically+into+the+Promoters+of+Pol+II+Transcribed+Genes&rft.au=Levin%2C+Henry&rft.aulast=Levin&rft.aufirst=Henry&rft.date=2006-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+American+Society+for+Microbiology+on+Mobile+DNA&rft.issn=&rft_id=info:doi/ L2 - http://www.asm.org/Meetings/index.asp?bid=37149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis. AN - 67685651; 16205634 AB - The CCAAT/enhancer binding protein beta (C/EBP beta) is implicated in the regulation of many different molecular and physiological processes. Mice with a germline deletion of C/EBP beta (C/EBP beta(-/-)) display phenotypes in a multitude of cell types and organ systems, including skin where C/EBP beta(-/-) mice exhibit increased apoptosis in epidermal keratinocytes in response to carcinogen treatment and are completely resistant to carcinogen-induced skin tumorigenesis. To determine the contribution of systemic versus cell autonomous functions of C/EBP beta to specific phenotypes, mice with a conditional 'floxed' C/EBP beta null allele were generated. Epidermal-specific deletion of C/EBP beta was achieved by Cre recombinase expression from a keratin 5 (K5) promoter. Similar to C/EBP beta(-/-) mice, K5-Cre;C/EBP beta(fl/fl) mice were completely refractory to 7,12 dimethylbenz[a]anthracene (DMBA)-induced skin tumorigenesis and these mice displayed increased DMBA-induced apoptosis in epidermal keratinocytes compared to wild-type mice. In contrast, mice lacking the related gene, C/EBP delta, were not resistant to DMBA-induced skin tumorigenesis, indicating a unique role of C/EBP beta in skin tumor development. Our findings demonstrate that C/EBP beta exerts an essential, keratinocyte-intrinsic role in cell survival in response to carcinogen treatment and the elimination of C/EBP beta in keratinocytes is sufficient to confer complete resistance of the skin to chemical carcinogenesis. Oncogene (2006) 25, 1272-1276. doi:10.1038/sj.onc.1209144; published online 3 October 2005. JF - Oncogene AU - Sterneck, E AU - Zhu, S AU - Ramirez, A AU - Jorcano, J L AU - Smart, R C AD - Molecular Mechanisms in Development Group, Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD , USA. Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 SP - 1272 EP - 1276 VL - 25 IS - 8 SN - 0950-9232, 0950-9232 KW - CCAAT-Enhancer-Binding Protein-beta KW - 0 KW - Carcinogens KW - Keratin-15 KW - Keratin-5 KW - Krt1-15 protein, mouse KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Keratins KW - 68238-35-7 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Keratins -- genetics KW - Tetradecanoylphorbol Acetate -- toxicity KW - Animals KW - Carcinogens -- toxicity KW - Mice KW - Mice, Knockout KW - Integrases -- metabolism KW - Promoter Regions, Genetic KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Mice, Inbred C57BL KW - Female KW - Apoptosis KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- pathology KW - CCAAT-Enhancer-Binding Protein-beta -- physiology KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Skin Neoplasms -- metabolism KW - CCAAT-Enhancer-Binding Protein-beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Conditional+ablation+of+C%2FEBP+beta+demonstrates+its+keratinocyte-specific+requirement+for+cell+survival+and+mouse+skin+tumorigenesis.&rft.au=Sterneck%2C+E%3BZhu%2C+S%3BRamirez%2C+A%3BJorcano%2C+J+L%3BSmart%2C+R+C&rft.aulast=Sterneck&rft.aufirst=E&rft.date=2006-02-23&rft.volume=25&rft.issue=8&rft.spage=1272&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2003 Feb;23(3):1044-53 [12529408] Toxicol Sci. 2002 Sep;69(1):42-8 [12215659] Carcinogenesis. 2003 May;24(5):817-26 [12771024] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6546-51 [12732721] Cell. 2003 Aug 8;114(3):323-34 [12914697] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Oncogene. 2004 Feb 26;23(8):1549-57 [14716301] Mol Cell Biol. 2004 Apr;24(8):3238-50 [15060147] Genesis. 2004 May;39(1):52-7 [15124227] Mol Cell Biol. 2004 Sep;24(17):7380-91 [15314150] Cancer Res. 1983 May;43(5 Suppl):2465s-2468s [6339050] Cell. 1995 Jan 27;80(2):353-61 [7530603] EMBO J. 1995 May 1;14(9):1932-41 [7744000] J Exp Med. 1996 Oct 1;184(4):1561-6 [8879230] Genes Dev. 1997 Sep 1;11(17):2153-62 [9303532] J Invest Dermatol. 1998 Jun;110(6):939-45 [9620302] Genes Dev. 1998 Jun 15;12(12):1907-16 [9637691] J Biol Chem. 1998 Oct 16;273(42):27686-94 [9765305] J Biol Chem. 1998 Nov 6;273(45):29279-82 [9792624] Br J Cancer. 1999 Mar;79(7-8):1240-8 [10098766] Mol Cell Biol. 1999 Oct;19(10):7181-90 [10490653] Cancer Cell. 2004 Nov;6(5):447-58 [15542429] Cancer Res. 2005 Feb 1;65(3):861-7 [15705884] Cancer Res. 2005 Apr 1;65(7):2592-601 [15805255] J Cell Sci. 2005 Jun 15;118(Pt 12):2545-55 [15944395] Int J Cancer. 2000 May 1;86(3):337-43 [10760820] Methods Mol Biol. 2001;158:47-63 [11236671] Nat Rev Genet. 2001 Oct;2(10):743-55 [11584291] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):207-12 [11756662] Biochem J. 2002 Aug 1;365(Pt 3):561-75 [12006103] Oncogene. 2003 Feb 13;22(6):869-83 [12584567] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Immune Aspects of Type 1 Diabetes and Islet Transplantation T2 - 2006 Keystone Symposia on Towards Understanding Islet Biology (X1) AN - 40096403; 4098926 JF - 2006 Keystone Symposia on Towards Understanding Islet Biology (X1) AU - Harlan, David M Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 KW - Transplantation KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40096403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Towards+Understanding+Islet+Biology+%28X1%29&rft.atitle=Immune+Aspects+of+Type+1+Diabetes+and+Islet+Transplantation&rft.au=Harlan%2C+David+M&rft.aulast=Harlan&rft.aufirst=David&rft.date=2006-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Towards+Understanding+Islet+Biology+%28X1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=779 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Islet Precursors from Mature Islet Cells T2 - 2006 Keystone Symposia on Pancreatic Islets: From Development to Transplantation (X2) AN - 39899146; 4143380 JF - 2006 Keystone Symposia on Pancreatic Islets: From Development to Transplantation (X2) AU - Gershengorn, Marvin C Y1 - 2006/02/23/ PY - 2006 DA - 2006 Feb 23 KW - Islets of Langerhans KW - Islet cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Pancreatic+Islets%3A+From+Development+to+Transplantation+%28X2%29&rft.atitle=Human+Islet+Precursors+from+Mature+Islet+Cells&rft.au=Gershengorn%2C+Marvin+C&rft.aulast=Gershengorn&rft.aufirst=Marvin&rft.date=2006-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Pancreatic+Islets%3A+From+Development+to+Transplantation+%28X2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=778 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI Research Training and Early Career Development Opportunities T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40143119; 4098813 JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Skarlatos, Sonia I Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Training KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40143119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=NHLBI+Research+Training+and+Early+Career+Development+Opportunities&rft.au=Skarlatos%2C+Sonia+I&rft.aulast=Skarlatos&rft.aufirst=Sonia&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vascular Proliferation and Inflammation: Lessons Learned from Genetic Diseases T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40140004; 4098814 JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Nabel, Elizabeth G Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Vascular system KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40140004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=Vascular+Proliferation+and+Inflammation%3A+Lessons+Learned+from+Genetic+Diseases&rft.au=Nabel%2C+Elizabeth+G&rft.aulast=Nabel&rft.aufirst=Elizabeth&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI and NIH Programs in Cell-Based Therapeutics T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40121913; 4098812 DE: JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Mockrin, Stephen C Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=NHLBI+and+NIH+Programs+in+Cell-Based+Therapeutics&rft.au=Mockrin%2C+Stephen+C&rft.aulast=Mockrin&rft.aufirst=Stephen&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fostering the Independence of New Investigators: NHLBI initiatives T2 - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AN - 40095988; 4098811 DE: JF - 2006 Keystone Symposia on Molecular Mechanisms of Cardiac Disease and Regeneration (C3) AU - Nabel, Elizabeth G Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40095988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.atitle=Fostering+the+Independence+of+New+Investigators%3A+NHLBI+initiatives&rft.au=Nabel%2C+Elizabeth+G&rft.aulast=Nabel&rft.aufirst=Elizabeth&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Molecular+Mechanisms+of+Cardiac+Disease+and+Regeneration+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association of Vision Science Librarians: Providing Information and Information Resources for Vision Care, Research and Education Worldwide T2 - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AN - 39852124; 4169796 JF - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AU - Sieving, Pamela C AU - Young, Judith Schaeffer Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Vision KW - Education KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.atitle=The+Association+of+Vision+Science+Librarians%3A+Providing+Information+and+Information+Resources+for+Vision+Care%2C+Research+and+Education+Worldwide&rft.au=Sieving%2C+Pamela+C%3BYoung%2C+Judith+Schaeffer&rft.aulast=Sieving&rft.aufirst=Pamela&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingeventos.com.br/site/inicio.asp?action=CTL&congresso= woctl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Adamantiades-Behcets Disease-A Trend in Time T2 - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AN - 39849960; 4171257 JF - 2006 World Opthalmology Congress (XXX International Congress of Ophthalmology, XXVI Panamerican Congress of Ophthalmology and XVII Brazilian Congress of Prevention of Blindness) AU - Kump, Leila I AU - Moeller, Kristy L AU - Kurup, Shree K AU - Reed, George F AU - Levy-Clarke, Grace AU - Nussenblatt, Robert B Y1 - 2006/02/19/ PY - 2006 DA - 2006 Feb 19 KW - Acquired immune deficiency syndrome KW - Uveitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.atitle=Ocular+Adamantiades-Behcets+Disease-A+Trend+in+Time&rft.au=Kump%2C+Leila+I%3BMoeller%2C+Kristy+L%3BKurup%2C+Shree+K%3BReed%2C+George+F%3BLevy-Clarke%2C+Grace%3BNussenblatt%2C+Robert+B&rft.aulast=Kump&rft.aufirst=Leila&rft.date=2006-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Opthalmology+Congress+%28XXX+International+Congress+of+Ophthalmology%2C+XXVI+Panamerican+Congress+of+Ophthalmology+and+XVII+Brazilian+Congress+of+Prevention+of+Blindness%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingeventos.com.br/site/inicio.asp?action=CTL&congresso= woctl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Refolding of HIV-1 Gp41 in the Course of Gp41-Mediated Membrane Fusion. T2 - 50th Annual Meeting of the Biophysical Society AN - 39863940; 4084017 JF - 50th Annual Meeting of the Biophysical Society AU - Blumenthal, Robert P Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Membrane fusion KW - Glycoprotein gp41 KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Refolding+of+HIV-1+Gp41+in+the+Course+of+Gp41-Mediated+Membrane+Fusion.&rft.au=Blumenthal%2C+Robert+P&rft.aulast=Blumenthal&rft.aufirst=Robert&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From Antibodies to the Innate Immune System T2 - 50th Annual Meeting of the Biophysical Society AN - 39822550; 4083955 JF - 50th Annual Meeting of the Biophysical Society AU - Davies, David R Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Immune system KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39822550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=From+Antibodies+to+the+Innate+Immune+System&rft.au=Davies%2C+David+R&rft.aulast=Davies&rft.aufirst=David&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Watching Proteins Function with Picosecond Time-Resolved X-Ray Crystallography T2 - 50th Annual Meeting of the Biophysical Society AN - 39811865; 4084027 JF - 50th Annual Meeting of the Biophysical Society AU - Anfinrud, Philip A Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - X-ray crystallography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Watching+Proteins+Function+with+Picosecond+Time-Resolved+X-Ray+Crystallography&rft.au=Anfinrud%2C+Philip+A&rft.aulast=Anfinrud&rft.aufirst=Philip&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast Kinetics and Mechanisms in Protein Folding T2 - 50th Annual Meeting of the Biophysical Society AN - 39811662; 4083992 JF - 50th Annual Meeting of the Biophysical Society AU - Eaton, William A Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Kinetics KW - Protein folding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Fast+Kinetics+and+Mechanisms+in+Protein+Folding&rft.au=Eaton%2C+William+A&rft.aulast=Eaton&rft.aufirst=William&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanostructures Design with Protein Building Blocks T2 - 50th Annual Meeting of the Biophysical Society AN - 39708355; 4083974 JF - 50th Annual Meeting of the Biophysical Society AU - Nussinov, Ruth Y1 - 2006/02/18/ PY - 2006 DA - 2006 Feb 18 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nanostructures+Design+with+Protein+Building+Blocks&rft.au=Nussinov%2C+Ruth&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2006-02-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/meetings/2006/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A new peptide input to learning and addiction. AN - 67657603; 16476658 AB - In this issue of Neuron, Borgland et al. report that the arousal-associated peptide orexin enhances LTP-like changes in glutamatergic excitability of ventral tegmental dopamine neurons. This parallels a similar effect of corticotropin-releasing factor and suggests a form of neuroadaptation that increases the likelihood of addiction relapse. JF - Neuron AU - Wise, Roy A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2006/02/16/ PY - 2006 DA - 2006 Feb 16 SP - 483 EP - 484 VL - 49 IS - 4 SN - 0896-6273, 0896-6273 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Neuropeptides KW - Orexins KW - Index Medicus KW - Rats KW - Animals KW - Ventral Tegmental Area -- drug effects KW - Ventral Tegmental Area -- physiology KW - Neuropeptides -- physiology KW - Learning -- physiology KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=A+new+peptide+input+to+learning+and+addiction.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2006-02-16&rft.volume=49&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Neuron. 2006 Feb 16;49(4):589-601 [16476667] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells. AN - 70719242; 16152591 AB - Vascular endothelial growth factor-D (VEGF-D) stimulates growth of vascular and lymphatic endothelial cells by signaling through the tyrosine kinase receptors KDR (VEGFR-2) and Flt-4 (VEGFR-3). In the present study, we examined the effects of VEGF-D on apoptosis in human MCF-7 and MDA-MB-231 breast carcinoma cells. Because VEGF-D was not expressed constitutively in vitro, stable VEGF-D transfectants were produced. The VEGF-D-expressing MCF-7 and MDA-MB-231 lines displayed resistance to apoptosis induced by hypoxia, staurosporin and cycloheximide. Increased Bcl-2 expression, decreased homogenous caspase activities and inhibition of poly(ADP-ribose) polymerase cleavage were associated with inhibition of apoptosis in VEGF-D-expressing clones. Also, caspase-3 activation was suppressed in the VEGF-D expressing MDA-MB-231 clone. The antiapoptotic effect of VEGF-D in vitro was recapitulated in vivo using VEGF-D-expressing MDA-MB-231 xenografts. The lack of VEGFR-2 protein expression by Western blot and ineffectiveness of a neutralizing VEGFR-2 antibody in eliminating the antiapoptotic effects of VEGF-D suggest a different and yet unknown signaling mechanism. Our findings indicate that VEGF-D has a novel function as a survival factor of breast carcinoma cells in addition to its established functions as an angiogenic and lymphangiogenic factor. JF - International journal of cancer AU - Akahane, Manabu AU - Akahane, Takemi AU - Matheny, Shannon L AU - Shah, Amy AU - Okajima, Eijiro AU - Thorgeirsson, Unnur P AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 841 EP - 849 VL - 118 IS - 4 SN - 0020-7136, 0020-7136 KW - Vascular Endothelial Growth Factor D KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Transfection KW - Humans KW - Antibody Formation KW - Neovascularization, Pathologic KW - Cell Hypoxia KW - Signal Transduction KW - Female KW - Vascular Endothelial Growth Factor D -- physiology KW - Apoptosis KW - Breast Neoplasms -- pathology KW - Vascular Endothelial Growth Factor D -- biosynthesis KW - Cell Survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Vascular+endothelial+growth+factor-D+is+a+survival+factor+for+human+breast+carcinoma+cells.&rft.au=Akahane%2C+Manabu%3BAkahane%2C+Takemi%3BMatheny%2C+Shannon+L%3BShah%2C+Amy%3BOkajima%2C+Eijiro%3BThorgeirsson%2C+Unnur+P&rft.aulast=Akahane&rft.aufirst=Manabu&rft.date=2006-02-15&rft.volume=118&rft.issue=4&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. AN - 70717682; 16262601 AB - Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a profound inflammatory syndrome with erosive arthritis, autoimmunity and myeloid hyperplasia. Previous studies showed that TTP is phosphorylated extensively in intact cells. However, limited information is available about the identities of these phosphorylation sites. We investigated the phosphorylation sites in human TTP from transfected HEK-293 cells by MS and site-directed mutagenesis. A number of phosphorylation sites including Ser66, Ser88, Thr92, Ser169, Ser186, Ser197, Ser218, Ser228, Ser276 and Ser296 were identified by MS analyses using MALDI (matrix-assisted laser-desorption-ionization)-MS, MALDI-tandem MS, LC (liquid chromatography)-tandem MS and multidimensional protein identification technology. Mutations of Ser197, Ser218 and Ser228 to alanine in the human protein significantly increased TTP's gel mobility (likely to be stoichiometric), whereas mutations at the other sites had little effect on its gel mobility. Dephosphorylation and in vivo labelling studies showed that mutant proteins containing multiple mutations were still phosphorylated, and all were able to bind to RNA probes containing AREs. Confocal microscopy showed a similar cytosolic localization of TTP among the various proteins. Ser197, Ser218 and Ser228 are predicted by motif scanning to be potential sites for protein kinase A, glycogen synthase kinase-3 and extracellular-signal-regulated kinase 1 (both Ser218 and Ser228) respectively. The present study has identified multiple phosphorylation sites in the anti-inflammatory protein TTP in mammalian cells and should provide the molecular basis for further studies on the function and regulation of TTP in controlling pro-inflammatory cytokines. JF - The Biochemical journal AU - Cao, Heping AU - Deterding, Leesa J AU - Venable, John D AU - Kennington, Elizabeth A AU - Yates, John R AU - Tomer, Kenneth B AU - Blackshear, Perry J AD - Laboratories of Neurobiology and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. caoh@ba.ars.usda.gov Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 285 EP - 297 VL - 394 KW - Anti-Inflammatory Agents KW - 0 KW - Tristetraprolin KW - Index Medicus KW - Mass Spectrometry KW - Sequence Alignment KW - Phosphorylation KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Mutation KW - Cell Line KW - Protein Transport KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Anti-Inflammatory Agents -- metabolism KW - Anti-Inflammatory Agents -- chemistry KW - Tristetraprolin -- chemistry KW - Tristetraprolin -- metabolism KW - Tristetraprolin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70717682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Identification+of+the+anti-inflammatory+protein+tristetraprolin+as+a+hyperphosphorylated+protein+by+mass+spectrometry+and+site-directed+mutagenesis.&rft.au=Cao%2C+Heping%3BDeterding%2C+Leesa+J%3BVenable%2C+John+D%3BKennington%2C+Elizabeth+A%3BYates%2C+John+R%3BTomer%2C+Kenneth+B%3BBlackshear%2C+Perry+J&rft.aulast=Cao&rft.aufirst=Heping&rft.date=2006-02-15&rft.volume=394&rft.issue=&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-24 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 2001 Oct 1;359(Pt 1):1-16 [11563964] Mol Cell Biol. 2001 Oct;21(19):6461-9 [11533235] J Biol Chem. 2002 Mar 15;277(11):9606-13 [11782475] J Biol Chem. 2002 May 17;277(20):18029-36 [11886850] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5 [12060738] Biochem Soc Trans. 2002 Nov;30(Pt 6):945-52 [12440952] Arch Biochem Biophys. 2003 Apr 1;412(1):106-20 [12646273] Mol Cell Biol. 2003 Jun;23(11):3798-812 [12748283] Nucleic Acids Res. 2003 Jul 1;31(13):3635-41 [12824383] J Biol Chem. 2003 Oct 3;278(40):38593-600 [14514795] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2011-6 [14769925] J Biol Chem. 2004 Mar 12;279(11):10176-84 [14688255] EMBO J. 2004 Mar 24;23(6):1313-24 [15014438] J Biol Chem. 2004 May 14;279(20):21489-99 [15010466] Anal Chem. 2004 May 15;76(10):2928-37 [15144207] Proteomics. 2004 Jun;4(6):1633-49 [15174133] Mol Cell Biol. 2004 Jul;24(14):6445-55 [15226444] J Biol Chem. 2004 Aug 13;279(33):34496-504 [15194681] Development. 2004 Oct;131(19):4883-93 [15342461] Biochemistry. 2004 Nov 2;43(43):13724-38 [15504035] J Biol Chem. 1975 Oct 10;250(19):7795-801 [170270] J Biol Chem. 1979 Apr 10;254(7):2499-508 [218941] Oncogene. 1989 Jan;4(1):119-20 [2915901] J Biol Chem. 1990 Sep 25;265(27):16556-63 [2204625] J Biol Chem. 1990 Nov 5;265(31):19185-91 [1699942] J Biol Chem. 1995 Jun 2;270(22):13341-7 [7768935] Immunity. 1996 May;4(5):445-54 [8630730] Mol Endocrinol. 1996 Feb;10(2):140-6 [8825554] J Biol Chem. 1997 Jan 10;272(2):952-60 [8995387] Science. 1998 Aug 14;281(5379):1001-5 [9703499] Mol Cell Biol. 1999 Jun;19(6):4311-23 [10330172] Biol Reprod. 2005 Aug;73(2):297-307 [15814898] Blood. 2000 Mar 15;95(6):1891-9 [10706852] J Biol Chem. 2000 Apr 7;275(14):10463-71 [10744736] J Am Soc Mass Spectrom. 2000 Apr;11(4):273-82 [10757163] Arch Biochem Biophys. 2000 Oct 15;382(2):310-3 [11068883] Nat Biotechnol. 2001 Apr;19(4):348-53 [11283593] Endocr Rev. 2001 Apr;22(2):153-83 [11294822] J Biol Chem. 2001 Jun 22;276(25):23144-54 [11279239] Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508 [11435226] Mol Cell Biol. 2001 Sep;21(17):5778-89 [11486017] J Biol Chem. 2001 Nov 9;276(45):42580-7 [11546803] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. AN - 67672794; 16488997 AB - The vast majority of deaths associated with cancer are a consequence of a complex phenotypic behavior, metastasis, by which tumor cells spread from their primary site of origin to regional and distant sites. This process requires the tumor cell to make numerous adjustments, both subtle and dramatic, to successfully reach, survive, and flourish at favorable secondary sites. It has been suggested that molecular mechanisms accounting for metastatic behavior can recapitulate those employed during embryogenesis. We have shown that the homeodomain transcription factor Six1, known to be required for normal development of migratory myogenic progenitor cells, is sufficient to promote metastatic spread in a mouse model of the pediatric skeletal muscle cancer rhabdomyosarcoma. Here, we report that Six1 is able to activate the expression of a set of protumorigenic genes (encoding cyclin D1, c-Myc, and Ezrin) that can control cell proliferation, survival, and motility. Although the role of Ezrin in cytoskeletal organization and adhesion has been well studied, the means by which its expression is regulated are poorly understood. We now show that the gene encoding Ezrin is a direct transcriptional target of Six1. Moreover, Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers. Our data indicate that Ezrin represents a promising therapeutic target for patients with advanced-stage rhabdomyosarcoma and perhaps other malignancies. JF - Cancer research AU - Yu, Yanlin AU - Davicioni, Elai AU - Triche, Timothy J AU - Merlino, Glenn AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 1982 EP - 1989 VL - 66 IS - 4 SN - 0008-5472, 0008-5472 KW - Cytoskeletal Proteins KW - 0 KW - Homeodomain Proteins KW - Proto-Oncogene Proteins c-myc KW - RNA, Small Interfering KW - SIX1 protein, human KW - Six1 protein, mouse KW - ezrin KW - Cyclin D1 KW - 136601-57-5 KW - Index Medicus KW - Animals KW - Humans KW - Proto-Oncogene Proteins c-myc -- genetics KW - RNA, Small Interfering -- genetics KW - Cyclin D1 -- biosynthesis KW - Cyclin D1 -- genetics KW - Mice KW - Mice, Nude KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transcriptional Activation KW - Gene Expression Regulation, Neoplastic KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Transfection KW - Neoplasm Metastasis KW - RNA Interference KW - Male KW - Cytoskeletal Proteins -- biosynthesis KW - Rhabdomyosarcoma -- genetics KW - Homeodomain Proteins -- biosynthesis KW - Homeodomain Proteins -- genetics KW - Rhabdomyosarcoma -- pathology KW - Cytoskeletal Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67672794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+homeoprotein+six1+transcriptionally+activates+multiple+protumorigenic+genes+but+requires+ezrin+to+promote+metastasis.&rft.au=Yu%2C+Yanlin%3BDavicioni%2C+Elai%3BTriche%2C+Timothy+J%3BMerlino%2C+Glenn&rft.aulast=Yu&rft.aufirst=Yanlin&rft.date=2006-02-15&rft.volume=66&rft.issue=4&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene promoter methylation in prostate tumor-associated stromal cells. AN - 67660566; 16478744 AB - Gene expression can be silenced through the methylation of specific sites in the promoter region. This mechanism of gene silencing has an important role in the carcinogenesis of prostate and other cancers. Although tumor-associated stromal cells also exhibit changes in gene expression, promoter methylation has not been described in these cells. Tumor epithelia, tumor-associated stroma and normal epithelia, and stroma adjacent to tumor tissues were isolated from whole-mount prostatectomy specimens (two per patient) of patients (n = 5) with localized prostate cancer and from normal epithelia and stroma from benign prostate hyperplasia specimens (two per patient) from men (n = 5) without prostate cancer by using laser capture microdissection or expression microdissection. The methylation status of three genes important in prostate carcinogenesis, GSTP1, RARbeta2, and CD44, were evaluated using quantitative methylation-sensitive polymerase chain reaction. GSTP1 and RARbeta2 were methylated in the tumor epithelium of all five prostate cancer patients and in the tumor-associated stroma in four of the five patients. CD44 was methylated in the tumor epithelium from four of the five patients but not in the tumor stroma. GSTP1 and RARbeta2 were methylated in normal epithelium of two and four patients, respectively, and in normal stroma of one and two patients, respectively, that were isolated from regions adjacent to the tumors and may have resulted from a tumor-field effect; CD44 methylation was not observed in normal epithelium or stroma. In contrast, normal epithelia and stroma from benign prostate hyperplasia specimens showed no promoter methylation in GSTP1, RARbeta2, or CD44. The observation of promoter methylation in the non-neoplastic cells of the prostate tumor microenvironment may advance our understanding of prostate cancer development and progression and lead to new diagnostic and prognostic markers and therapeutic targets. JF - Journal of the National Cancer Institute AU - Hanson, Jeffrey A AU - Gillespie, John W AU - Grover, Amelia AU - Tangrea, Michael A AU - Chuaqui, Rodrigo F AU - Emmert-Buck, Michael R AU - Tangrea, Joseph A AU - Libutti, Stephen K AU - Linehan, W Marston AU - Woodson, Karen G AD - Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 255 EP - 261 VL - 98 IS - 4 KW - Antigens, CD44 KW - 0 KW - Receptors, Retinoic Acid KW - retinoic acid receptor beta KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Index Medicus KW - Microdissection KW - Epithelial Cells -- metabolism KW - Prostatectomy KW - Humans KW - Polymerase Chain Reaction -- methods KW - Aged KW - Middle Aged KW - Laser Therapy KW - Cell Line, Tumor KW - Prostate -- cytology KW - Male KW - Receptors, Retinoic Acid -- genetics KW - Prostatic Neoplasms -- metabolism KW - Glutathione S-Transferase pi -- genetics KW - Promoter Regions, Genetic KW - DNA Methylation KW - Gene Silencing KW - Prostatic Neoplasms -- surgery KW - Antigens, CD44 -- genetics KW - Prostatic Neoplasms -- genetics KW - Stromal Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67660566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Gene+promoter+methylation+in+prostate+tumor-associated+stromal+cells.&rft.au=Hanson%2C+Jeffrey+A%3BGillespie%2C+John+W%3BGrover%2C+Amelia%3BTangrea%2C+Michael+A%3BChuaqui%2C+Rodrigo+F%3BEmmert-Buck%2C+Michael+R%3BTangrea%2C+Joseph+A%3BLibutti%2C+Stephen+K%3BLinehan%2C+W+Marston%3BWoodson%2C+Karen+G&rft.aulast=Hanson&rft.aufirst=Jeffrey&rft.date=2006-02-15&rft.volume=98&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The limitations due to exposure detection limits for regression models. AN - 67634569; 16394206 AB - Biomarker use in exposure assessment is increasingly common, and consideration of related issues is of growing importance. Exposure quantification may be compromised when measurement is subject to a lower threshold. Statistical modeling of such data requires a decision regarding the handling of such readings. Various authors have considered this problem. In the context of linear regression analysis, Richardson and Ciampi (Am J Epidemiol 2003;157:355-63) proposed replacement of data below a threshold by a constant equal to the expectation for such data to yield unbiased estimates. Use of such an imputation has some limitations; distributional assumptions are required, and bias reduction in estimation of regression parameters is asymptotic, thereby presenting concerns about small studies. In this paper, the authors propose distribution-free methods for managing values below detection limits and evaluate the biases that may result when exposure measurement is constrained by a lower threshold. The authors utilize an analytical approach and a simulation study to assess the effects of the proposed replacement method on estimates. These results may inform decisions regarding analytical plans for future studies and provide a possible explanation for some amount of the discordance seen in extant literature. JF - American journal of epidemiology AU - Schisterman, Enrique F AU - Vexler, Albert AU - Whitcomb, Brian W AU - Liu, Aiyi AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rm. 7B03, Rockville, MD 20852, USA. schistee@mail.nih.gov Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 374 EP - 383 VL - 163 IS - 4 SN - 0002-9262, 0002-9262 KW - Biomarkers KW - 0 KW - Index Medicus KW - Humans KW - Monte Carlo Method KW - Decision Making KW - Statistical Distributions KW - Risk Assessment KW - Logistic Models KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Bias (Epidemiology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67634569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=The+limitations+due+to+exposure+detection+limits+for+regression+models.&rft.au=Schisterman%2C+Enrique+F%3BVexler%2C+Albert%3BWhitcomb%2C+Brian+W%3BLiu%2C+Aiyi&rft.aulast=Schisterman&rft.aufirst=Enrique&rft.date=2006-02-15&rft.volume=163&rft.issue=4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Clin Nutr. 1997 Apr;65(4 Suppl):1179S-1186S [9094918] AIHAJ. 2001 Mar-Apr;62(2):195-8 [11331991] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Stat Med. 1989 Sep;8(9):1051-69; discussion 1071-3 [2799131] Epidemiology. 2002 Nov;13(6):729-33 [12410018] Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation. AN - 67623851; 16397898 AB - Prenatal and postnatal ethanol exposure induces abnormal cell death in the nervous system. We have previously reported that docosahexaenoic acid (DHA; 22:6n-3) prevents neuronal apoptosis through promoting phosphatidylserine (PS) accumulation. Previously, we have shown in C6 glioma cells that ethanol inhibits the accumulation of PS caused by DHA supplementation. In this report, we demonstrate that in vitro or in vivo exposure to ethanol inhibits DHA-dependent PS accumulation and neuronal survival. We found that Neuro 2A cells exposed to ethanol accumulated considerably less PS in response to the DHA enrichment and were less effective at phosphorylating Akt and suppressing caspase-3 activity under serum-starved or staurosporine-treated conditions. The in vivo paradigm correlated well with the in vitro findings. We found that the total PS and DHA contents in the fetal hippocampus were slightly but significantly lowered by the prenatal ethanol exposure. Fetal hippocampal cultures obtained at embryonic day 18 from ethanol-treated pregnant rats contained significantly higher apoptotic cells after 7 days in vitro under basal conditions and exhibited particular susceptibility to cell death induced by trophic factor removal in comparison with the pair-fed control group. The reduction of PS and the resulting neuronal cell death inappropriately enhanced during development may contribute to the defects in brain function often observed in fetal alcohol syndrome. JF - Journal of neuroscience research AU - Akbar, Mohammed AU - Baick, Joseph AU - Calderon, Frances AU - Wen, Zhiming AU - Kim, Hee-Yong AD - Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, Maryland. Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 432 EP - 440 VL - 83 IS - 3 SN - 0360-4012, 0360-4012 KW - Central Nervous System Depressants KW - 0 KW - Fatty Acids KW - Phosphatidylserines KW - Docosahexaenoic Acids KW - 25167-62-8 KW - Ethanol KW - 3K9958V90M KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Casp3 protein, rat KW - Caspase 3 KW - Caspases KW - Index Medicus KW - Neuroblastoma -- pathology KW - Animals KW - Drug Interactions KW - Docosahexaenoic Acids -- pharmacology KW - Dose-Response Relationship, Drug KW - Mice KW - Blotting, Western -- methods KW - Caspases -- metabolism KW - Pregnancy KW - In Situ Nick-End Labeling -- methods KW - Fatty Acids -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Docosahexaenoic Acids -- metabolism KW - Hippocampus -- cytology KW - Chromatography, High Pressure Liquid -- methods KW - Serum -- physiology KW - Mass Spectrometry -- methods KW - Embryo, Mammalian KW - Female KW - Central Nervous System Depressants -- toxicity KW - Phosphatidylserines -- metabolism KW - Neurons -- drug effects KW - Apoptosis -- drug effects KW - Ethanol -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67623851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Ethanol+promotes+neuronal+apoptosis+by+inhibiting+phosphatidylserine+accumulation.&rft.au=Akbar%2C+Mohammed%3BBaick%2C+Joseph%3BCalderon%2C+Frances%3BWen%2C+Zhiming%3BKim%2C+Hee-Yong&rft.aulast=Akbar&rft.aufirst=Mohammed&rft.date=2006-02-15&rft.volume=83&rft.issue=3&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Selective Gene Loss in the Evolution of Arthropod Transmission of Plague T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 40013972; 4153137 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Erickson, D L AU - Jarrett, C O AU - Hinnebusch, B J Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Evolutionary genetics KW - Plague UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40013972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Selective+Gene+Loss+in+the+Evolution+of+Arthropod+Transmission+of+Plague&rft.au=Erickson%2C+D+L%3BJarrett%2C+C+O%3BHinnebusch%2C+B+J&rft.aulast=Erickson&rft.aufirst=D&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity Determinants for Yersinia pestis Virulence Plasmid Segregation T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39954917; 4152983 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Dabrazhynetskaya, A Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Virulence KW - Plasmids KW - Specificity KW - Yersinia pestis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39954917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Specificity+Determinants+for+Yersinia+pestis+Virulence+Plasmid+Segregation&rft.au=Dabrazhynetskaya%2C+A&rft.aulast=Dabrazhynetskaya&rft.aufirst=A&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis and Modification of Bacillus anthracis pXO2 Genes Involved in Polyglutamate Capsule Synthesis T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39954803; 4152972 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Pomerantsev, A P AU - Galloway, C R AU - Leppla, S H Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Bacillus anthracis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39954803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Analysis+and+Modification+of+Bacillus+anthracis+pXO2+Genes+Involved+in+Polyglutamate+Capsule+Synthesis&rft.au=Pomerantsev%2C+A+P%3BGalloway%2C+C+R%3BLeppla%2C+S+H&rft.aulast=Pomerantsev&rft.aufirst=A&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Dual Role for a Viral RNA Polymerase in Antagonism of Host Interferon Responses T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39933768; 4153135 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Bloom, M E AU - Park, G M AU - Morris, K AU - Hallett, R AU - Best, S M Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Antagonism KW - Interferon KW - DNA-directed RNA polymerase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=A+Dual+Role+for+a+Viral+RNA+Polymerase+in+Antagonism+of+Host+Interferon+Responses&rft.au=Bloom%2C+M+E%3BPark%2C+G+M%3BMorris%2C+K%3BHallett%2C+R%3BBest%2C+S+M&rft.aulast=Bloom&rft.aufirst=M&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of B. anthracis Edema and Lethal Toxins Alone and in Combination in Rats T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39933589; 4153106 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Cui, X AU - Li, Y. AU - Sherer, K AU - Su, J. AU - Li, X. AU - Laird, M AU - Subramanian, M AU - Leppla, S AU - Moayeri, M AU - Fitz, Y AU - Eichacker, P Q Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Toxins KW - Rats KW - Edema UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Effects+of+B.+anthracis+Edema+and+Lethal+Toxins+Alone+and+in+Combination+in+Rats&rft.au=Cui%2C+X%3BLi%2C+Y.%3BSherer%2C+K%3BSu%2C+J.%3BLi%2C+X.%3BLaird%2C+M%3BSubramanian%2C+M%3BLeppla%2C+S%3BMoayeri%2C+M%3BFitz%2C+Y%3BEichacker%2C+P+Q&rft.aulast=Cui&rft.aufirst=X&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of State Tobacco Control Programs on Prevalence and Individual Risk of Being a Hardcore Smoker T2 - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 39922689; 4142620 JF - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Augustson, Erik M AU - Rogers, Scott Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Tobacco KW - Control programs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=The+Impact+of+State+Tobacco+Control+Programs+on+Prevalence+and+Individual+Risk+of+Being+a+Hardcore+Smoker&rft.au=Augustson%2C+Erik+M%3BRogers%2C+Scott&rft.aulast=Augustson&rft.aufirst=Erik&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - https://www.srnt.org/meeting/2006/pdf/2006Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase I Safety and Immunogenicity of a Multi-Strain Ebola DNA Vaccine Encoding Envelope Glycoprotein and Nucleoprotein T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39921865; 4153149 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Martin, J E AU - Sullivan, N J AU - Enama, M E AU - Gordon, I J AU - Roederer, M AU - Koup, R A AU - Bailer, R T AU - Chakrabarti, B K AU - Gomez, P L AU - Andrews, C A AU - Moodie, Z AU - Mascola, J R AU - Nabel, G J AU - Graham, B S Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Vaccines KW - Envelopes KW - Nucleoproteins KW - DNA vaccines KW - Glycoproteins KW - Immunogenicity KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Phase+I+Safety+and+Immunogenicity+of+a+Multi-Strain+Ebola+DNA+Vaccine+Encoding+Envelope+Glycoprotein+and+Nucleoprotein&rft.au=Martin%2C+J+E%3BSullivan%2C+N+J%3BEnama%2C+M+E%3BGordon%2C+I+J%3BRoederer%2C+M%3BKoup%2C+R+A%3BBailer%2C+R+T%3BChakrabarti%2C+B+K%3BGomez%2C+P+L%3BAndrews%2C+C+A%3BMoodie%2C+Z%3BMascola%2C+J+R%3BNabel%2C+G+J%3BGraham%2C+B+S&rft.aulast=Martin&rft.aufirst=J&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subunit Recombinant Protein Vaccine Protects Against Monkeypox T2 - 4th Annual American Society for Microbiology Biodefense Research Meeting AN - 39919960; 4153079 JF - 4th Annual American Society for Microbiology Biodefense Research Meeting AU - Heraud, J AU - Edghill-Smith, Y AU - Ayala, V AU - Kalyanaraman, V AU - Manischewitz, J AU - Nalca, A AU - Trindade, C AU - Hassett, M AU - Tsai, W AU - Venzon, D AU - Hryniewicz, A AU - Silvera, P AU - Bray, M AU - Seder, R AU - Golding, H AU - Hooper, J AU - Franchini, G Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Vaccines KW - Monkeypox KW - Disease control KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39919960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.atitle=Subunit+Recombinant+Protein+Vaccine+Protects+Against+Monkeypox&rft.au=Heraud%2C+J%3BEdghill-Smith%2C+Y%3BAyala%2C+V%3BKalyanaraman%2C+V%3BManischewitz%2C+J%3BNalca%2C+A%3BTrindade%2C+C%3BHassett%2C+M%3BTsai%2C+W%3BVenzon%2C+D%3BHryniewicz%2C+A%3BSilvera%2C+P%3BBray%2C+M%3BSeder%2C+R%3BGolding%2C+H%3BHooper%2C+J%3BFranchini%2C+G&rft.aulast=Heraud&rft.aufirst=J&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+American+Society+for+Microbiology+Biodefense+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting Conditioning Processes to Reduce Tobacco Smoking T2 - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 39913016; 4142650 JF - 12th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Le Foll, Bernard Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 KW - Smoking KW - Tobacco smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Targeting+Conditioning+Processes+to+Reduce+Tobacco+Smoking&rft.au=Le+Foll%2C+Bernard&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2006-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - https://www.srnt.org/meeting/2006/pdf/2006Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification of 12Cys beta on tubulin as the binding site of tubulyzine AN - 19969957; 6653299 AB - We have undertaken quantitative binding site studies in order to identify the binding site of the known microtubule destabilizing agents, the tubulyzines, in the tubulin dimer. Two different approaches were employed that utilized the tubulyzines and their derivatives. The first approach was based on a chemical affinity labeling method using tubulyzine affinity derivatives, and the second approach employed the mass spectrometric measurement of the differential reactivity of cysteines using the tubulyzines and monobromobimane. Based on overlapping data from these two approaches, we propose that the tubulyzines bind at the guanosine-5'-triphosphate binding site of beta -tubulin. Interestingly, we also show that the tubulyzines' binding to tubulin induces a conformational change in tubulin that prevents further interaction of the 239Cys beta with other reagents. JF - Bioorganic and Medicinal Chemistry AU - Kim, Yeoun Jin AU - Sackett, Dan L AU - Schapira, Matthieu AU - Walsh, Daniel P AU - Min, Jaeki AU - Pannell, Lewis K AU - Chang, Young-Tae AD - National Institute of Diabetes, Digestive, Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA, yt.chang@nyu.edu Y1 - 2006/02/15/ PY - 2006 DA - 2006 Feb 15 SP - 1169 EP - 1175 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 4 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Tublin KW - Tubulyzine KW - Binding site KW - MS-DRC KW - Microtubules KW - Data processing KW - Cysteine KW - Tubulin KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19969957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Identification+of+12Cys+beta+on+tubulin+as+the+binding+site+of+tubulyzine&rft.au=Kim%2C+Yeoun+Jin%3BSackett%2C+Dan+L%3BSchapira%2C+Matthieu%3BWalsh%2C+Daniel+P%3BMin%2C+Jaeki%3BPannell%2C+Lewis+K%3BChang%2C+Young-Tae&rft.aulast=Kim&rft.aufirst=Yeoun&rft.date=2006-02-15&rft.volume=14&rft.issue=4&rft.spage=1169&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2005.09.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Microtubules; Data processing; Cysteine; Tubulin DO - http://dx.doi.org/10.1016/j.bmc.2005.09.069 ER - TY - CPAPER T1 - EGFR Inhibitors in Clinical Trials T2 - 2006 Keystone Symposia on Cancer and Kinases: Lessons from the Clinic (C2) AN - 40115830; 4098643 JF - 2006 Keystone Symposia on Cancer and Kinases: Lessons from the Clinic (C2) AU - Dancey, Janet Y1 - 2006/02/14/ PY - 2006 DA - 2006 Feb 14 KW - clinical trials KW - Inhibitors KW - Epidermal growth factor receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40115830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Cancer+and+Kinases%3A+Lessons+from+the+Clinic+%28C2%29&rft.atitle=EGFR+Inhibitors+in+Clinical+Trials&rft.au=Dancey%2C+Janet&rft.aulast=Dancey&rft.aufirst=Janet&rft.date=2006-02-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Cancer+and+Kinases%3A+Lessons+from+the+Clinic+%28C2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=766 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain-Computer-Interfaces (BCI) for Communication and Paralysis T2 - 10th Annual Meeting of the Biofeedback Foundation of Europe AN - 39843794; 4158801 JF - 10th Annual Meeting of the Biofeedback Foundation of Europe AU - Sitaram, Ranganatha AU - Cohen, Leo AU - Weber, Cornelia AU - Kubler, Andrea Y1 - 2006/02/14/ PY - 2006 DA - 2006 Feb 14 KW - Communication KW - Paralysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39843794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.atitle=Brain-Computer-Interfaces+%28BCI%29+for+Communication+and+Paralysis&rft.au=Sitaram%2C+Ranganatha%3BCohen%2C+Leo%3BWeber%2C+Cornelia%3BKubler%2C+Andrea&rft.aulast=Sitaram&rft.aufirst=Ranganatha&rft.date=2006-02-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.issn=&rft_id=info:doi/ L2 - http://www.bfe.org/meeting/SCIENTIFIC%20PROGRAM%20ON%20WEB.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Targeted Cross-linking of the Human beta -Globin Gene in Living Cells Mediated by a Triple Helix Forming Oligonucleotide AN - 19474838; 7171791 AB - Triple helix forming oligonucleotides (TFOs) may have utility as gene targeting reagents for "in situ" gene therapy of genetic disorders. Triplex formation is challenged by negative charge repulsion between third strand and duplex phosphates, and destabilizing positive charge repulsion between adjacent protonated cytosines within pyrimidine motif third strands. Here we describe the synthesis of TFOs designed to target a site in the human beta -globin gene, which is the locus for mutations that underlie the beta -globinopathies, including sickle cell anemia. The target is an uninterrupted polypurine:polypyrimidine sequence, containing four adjacent cytosines, next to a psoralen cross-link site. Pyrimidine motif TFOs that contained four adjacent cytosines or 5-methylcytosines did not form stable triplexes at physiological pH, despite the introduction of otherwise stabilizing base and sugar analogues. We synthesized a series of pso-TFOs containing 2'-O-methyl (OMe) and 2'-O-aminoethoxy substitutions (AE), as well as 8-oxo-adenine (A super(8)) and 2'-O-methylpseudoisocytidine (P) as neutral cytosine replacements. Thermal stability measurements indicated that TFOs with A super(8) did not meet criteria established in previous work. However, TFOs with P did form triplexes with appropriate T sub(m) and k sub(ON) values. A pso-TFO with AE and P residues was sufficiently active to permit the determination of targeting in living cells by direct measurement of cross-link formation at the target site. Our results validate the modification format described in our previous studies and indicate that P substitutions are an effective solution to the problem of targeting genomic sequences containing adjacent cytosines. JF - Biochemistry (Washington) AU - Shahid, KA AU - Majumdar, A AU - Alam, R AU - Liu, S-T AU - Kuan, J Y AU - Sui, X AU - Cuenoud, B AU - Glazer, P M AU - Miller, P S AU - Seidman, M M AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA Y1 - 2006/02/14/ PY - 2006 DA - 2006 Feb 14 SP - 1970 EP - 1978 VL - 45 IS - 6 SN - 0006-2960, 0006-2960 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Sugar KW - Gene targeting KW - Gene therapy KW - phosphates KW - psoralen KW - Oligonucleotides KW - Cytosine KW - Phosphate KW - pyrimidines KW - Thermal stability KW - genomics KW - Mutation KW - Sickle cell disease KW - pH effects KW - W 30925:Genetic Engineering KW - N 14840:Antisense, Nucleotide Analogs KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Targeted+Cross-linking+of+the+Human+beta+-Globin+Gene+in+Living+Cells+Mediated+by+a+Triple+Helix+Forming+Oligonucleotide&rft.au=Shahid%2C+KA%3BMajumdar%2C+A%3BAlam%2C+R%3BLiu%2C+S-T%3BKuan%2C+J+Y%3BSui%2C+X%3BCuenoud%2C+B%3BGlazer%2C+P+M%3BMiller%2C+P+S%3BSeidman%2C+M+M&rft.aulast=Shahid&rft.aufirst=KA&rft.date=2006-02-14&rft.volume=45&rft.issue=6&rft.spage=1970&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi0520986 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sugar; Gene targeting; Gene therapy; phosphates; Oligonucleotides; psoralen; Cytosine; Phosphate; pyrimidines; genomics; Thermal stability; pH effects; Sickle cell disease; Mutation DO - http://dx.doi.org/10.1021/bi0520986 ER - TY - CPAPER T1 - Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes T2 - 2006 Keystone Symposia on G Protein-Coupled Receptors: Evolving Concepts and New Techniques (C1) AN - 40141211; 4098729 JF - 2006 Keystone Symposia on G Protein-Coupled Receptors: Evolving Concepts and New Techniques (C1) AU - Wess, Jurgen Y1 - 2006/02/12/ PY - 2006 DA - 2006 Feb 12 KW - Mice KW - Neurotransmitters KW - Phenotypes KW - Acetylcholine receptors (muscarinic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40141211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+G+Protein-Coupled+Receptors%3A+Evolving+Concepts+and+New+Techniques+%28C1%29&rft.atitle=Muscarinic+Acetylcholine+Receptor+Knockout+Mice%3A+Novel+Phenotypes&rft.au=Wess%2C+Jurgen&rft.aulast=Wess&rft.aufirst=Jurgen&rft.date=2006-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+G+Protein-Coupled+Receptors%3A+Evolving+Concepts+and+New+Techniques+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=807 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancing Training Effects in Neurorehabilitation After Chronic Stroke: Cortical Stimulation, Drugs and Somatosensory Input T2 - 4th World Congress for NeuroRehabilitation (WCNR 2006) AN - 39766676; 4052397 JF - 4th World Congress for NeuroRehabilitation (WCNR 2006) AU - Cohen, Leonardo Y1 - 2006/02/12/ PY - 2006 DA - 2006 Feb 12 KW - Training KW - Drugs KW - Stroke KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39766676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+World+Congress+for+NeuroRehabilitation+%28WCNR+2006%29&rft.atitle=Enhancing+Training+Effects+in+Neurorehabilitation+After+Chronic+Stroke%3A+Cortical+Stimulation%2C+Drugs+and+Somatosensory+Input&rft.au=Cohen%2C+Leonardo&rft.aulast=Cohen&rft.aufirst=Leonardo&rft.date=2006-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+World+Congress+for+NeuroRehabilitation+%28WCNR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wcnr2006.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstitution of Efficient Concerted Integration by HIV Integrase: Reaction Pathway and Critical Intermediates T2 - 2006 Keystone Symposia on Nucleic Acid Enzymes (B7) AN - 40121631; 4098688 JF - 2006 Keystone Symposia on Nucleic Acid Enzymes (B7) AU - Li, Min Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Integrase KW - Integration KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Nucleic+Acid+Enzymes+%28B7%29&rft.atitle=Reconstitution+of+Efficient+Concerted+Integration+by+HIV+Integrase%3A+Reaction+Pathway+and+Critical+Intermediates&rft.au=Li%2C+Min&rft.aulast=Li&rft.aufirst=Min&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Nucleic+Acid+Enzymes+%28B7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure, DNA Recognition and Active Site Assembly of a New Class of DNA Transposase T2 - 2006 Keystone Symposia on Nucleic Acid Enzymes (B7) AN - 40092155; 4098684 JF - 2006 Keystone Symposia on Nucleic Acid Enzymes (B7) AU - Dyda, Fred Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - New classes KW - transposase KW - DNA structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40092155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Nucleic+Acid+Enzymes+%28B7%29&rft.atitle=Structure%2C+DNA+Recognition+and+Active+Site+Assembly+of+a+New+Class+of+DNA+Transposase&rft.au=Dyda%2C+Fred&rft.aulast=Dyda&rft.aufirst=Fred&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Nucleic+Acid+Enzymes+%28B7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concordance Across Microarray Platforms: Can it be Improved by the Use of Universal Standards? The External RNA Controls Consortium (ERCC) T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39971123; 4149466 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Kawasaki, E Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=Concordance+Across+Microarray+Platforms%3A+Can+it+be+Improved+by+the+Use+of+Universal+Standards%3F+The+External+RNA+Controls+Consortium+%28ERCC%29&rft.au=Kawasaki%2C+E&rft.aulast=Kawasaki&rft.aufirst=E&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification of Denatured Recombinant Proteins by Reverse-Phase HPLC and Monitoring of Disulfide Bonds Formation by Mass Spectrometry T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39954471; 4149718 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Chertov, O AU - Simpson, J AU - Yang, D AU - Esposito, D AU - Gillette, W K AU - Hartley, J L AU - Fisher, R J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Mass spectroscopy KW - Purification KW - Disulfide bonds KW - High-performance liquid chromatography KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39954471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=Purification+of+Denatured+Recombinant+Proteins+by+Reverse-Phase+HPLC+and+Monitoring+of+Disulfide+Bonds+Formation+by+Mass+Spectrometry&rft.au=Chertov%2C+O%3BSimpson%2C+J%3BYang%2C+D%3BEsposito%2C+D%3BGillette%2C+W+K%3BHartley%2C+J+L%3BFisher%2C+R+J&rft.aulast=Chertov&rft.aufirst=O&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multispectral Imaging of Cellular Targets Using Semiconductor Quantum Dots T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39945164; 4102840 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Fountaine, T AU - Wincovitch, S AU - Geho, D AU - Garfield, S AU - Pittaluga, S Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Multispectral+Imaging+of+Cellular+Targets+Using+Semiconductor+Quantum+Dots&rft.au=Fountaine%2C+T%3BWincovitch%2C+S%3BGeho%2C+D%3BGarfield%2C+S%3BPittaluga%2C+S&rft.aulast=Fountaine&rft.aufirst=T&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of EGFR Status in Sporadic and Hereditary Renal Tumors. Correlation between CISH and Immunohistochemistry T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39936038; 4101972 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Palau, M A AU - Torres-Cabala, C AU - Li Ning, E AU - Linehan, W M AU - Merino, M J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Immunohistochemistry KW - Kidneys KW - Epidermal growth factor receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39936038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Determination+of+EGFR+Status+in+Sporadic+and+Hereditary+Renal+Tumors.+Correlation+between+CISH+and+Immunohistochemistry&rft.au=Palau%2C+M+A%3BTorres-Cabala%2C+C%3BLi+Ning%2C+E%3BLinehan%2C+W+M%3BMerino%2C+M+J&rft.aulast=Palau&rft.aufirst=M&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Image Registration Using Shape-Constrained Mutual Information and Genetic Algorithms T2 - 2006 SPIE Meeting on Medical Imaging AN - 39927045; 4097911 JF - 2006 SPIE Meeting on Medical Imaging AU - Yuan, X AU - Chi-Fishman, G Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Image+Registration+Using+Shape-Constrained+Mutual+Information+and+Genetic+Algorithms&rft.au=Yuan%2C+X%3BChi-Fishman%2C+G&rft.aulast=Yuan&rft.aufirst=X&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Throughput SNP Genotyping: Comparing Single to Highly Multiplexed Technologies T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39926187; 4149556 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Welch, R A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Genotyping KW - Single-nucleotide polymorphism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=High+Throughput+SNP+Genotyping%3A+Comparing+Single+to+Highly+Multiplexed+Technologies&rft.au=Welch%2C+R+A&rft.aulast=Welch&rft.aufirst=R&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LC- Laser Induced Fluorescence Detection Combined with ESI Mass Spectrometry for Quantitative Proteomics T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39925995; 4149510 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Masuda, J AU - Morgan, N Y AU - Makusky, A J AU - Nishimura, M AU - Maruyama, S AU - Smith, P D AU - Phillips, T M AU - Kowalak, J A AU - Markey, S P Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Mass spectroscopy KW - Lasers KW - Fluorescence KW - Proteomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=LC-+Laser+Induced+Fluorescence+Detection+Combined+with+ESI+Mass+Spectrometry+for+Quantitative+Proteomics&rft.au=Masuda%2C+J%3BMorgan%2C+N+Y%3BMakusky%2C+A+J%3BNishimura%2C+M%3BMaruyama%2C+S%3BSmith%2C+P+D%3BPhillips%2C+T+M%3BKowalak%2C+J+A%3BMarkey%2C+S+P&rft.aulast=Masuda&rft.aufirst=J&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploiting Retroviral Protein Chemistry for Direct Fluorescent Labeling of Virions to Facilitate Studies of HIV-1 and SIV Interaction with Dendritic Cells T2 - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AN - 39920535; 4149489 JF - 10th International Meeting of the Association of Biomolecular Resource Facilities (ABRF 2006) AU - Chertova, E AU - Frank, I AU - Bess Jr, J AU - Roser, J AU - Pope, M AU - Ott, D AU - Lifson, J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Virions KW - Dendritic cells KW - Simian immunodeficiency virus KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.atitle=Exploiting+Retroviral+Protein+Chemistry+for+Direct+Fluorescent+Labeling+of+Virions+to+Facilitate+Studies+of+HIV-1+and+SIV+Interaction+with+Dendritic+Cells&rft.au=Chertova%2C+E%3BFrank%2C+I%3BBess+Jr%2C+J%3BRoser%2C+J%3BPope%2C+M%3BOtt%2C+D%3BLifson%2C+J&rft.aulast=Chertova&rft.aufirst=E&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={2BD871C9-1496 -4A50-B2B9-A63C7F4917C9}&AKey={23DAB33D-792E-4D4B-988C-4ABBEE81051D} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synchronous Navigation for CT Colonography T2 - 2006 SPIE Meeting on Medical Imaging AN - 39878927; 4097592 DE: JF - 2006 SPIE Meeting on Medical Imaging AU - Huang, A AU - Summers, R M AU - Roy, D Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Synchronous+Navigation+for+CT+Colonography&rft.au=Huang%2C+A%3BSummers%2C+R+M%3BRoy%2C+D&rft.aulast=Huang&rft.aufirst=A&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histopathologic, Immunohistochemical and Molecular Features of Screening Spiral Computed Tomography (SCT)-Detected Lung Cancers T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39875516; 4102680 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Pelosi, G AU - Fabbri, A AU - Masullo, M AU - Sozzi, G AU - Thunnissen, E AU - Prinsen, C AU - Pastorino, U AU - Viale, G Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Lung cancer KW - Computed tomography KW - Screening KW - Histopathology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Histopathologic%2C+Immunohistochemical+and+Molecular+Features+of+Screening+Spiral+Computed+Tomography+%28SCT%29-Detected+Lung+Cancers&rft.au=Pelosi%2C+G%3BFabbri%2C+A%3BMasullo%2C+M%3BSozzi%2C+G%3BThunnissen%2C+E%3BPrinsen%2C+C%3BPastorino%2C+U%3BViale%2C+G&rft.aulast=Pelosi&rft.aufirst=G&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Utilization of Chromosome Y Chromogenic in Situ Hybridization (CishTM) to Detect Male Cells in Surgical Pathology Specimens T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39874634; 4102834 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Silva, A S AU - Palau, M AU - Merino, M J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Pathology KW - Chromosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Utilization+of+Chromosome+Y+Chromogenic+in+Situ+Hybridization+%28CishTM%29+to+Detect+Male+Cells+in+Surgical+Pathology+Specimens&rft.au=Silva%2C+A+S%3BPalau%2C+M%3BMerino%2C+M+J&rft.aulast=Silva&rft.aufirst=A&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Vitreous Proteome: An Autopsy Study T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39866934; 4101300 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Rapkiewicz, A V AU - Lowenthal, M AU - Kleiner, D E AU - Liotta, L A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Autopsy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39866934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=The+Vitreous+Proteome%3A+An+Autopsy+Study&rft.au=Rapkiewicz%2C+A+V%3BLowenthal%2C+M%3BKleiner%2C+D+E%3BLiotta%2C+L+A&rft.aulast=Rapkiewicz&rft.aufirst=A&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Performance Tuning of Candidate Determination Methods for Computer Aided Detection of Colon Polyps T2 - 2006 SPIE Meeting on Medical Imaging AN - 39864037; 4097597 JF - 2006 SPIE Meeting on Medical Imaging AU - Bitter, I AU - Kelsey, M D AU - Summers, R M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Colon KW - Computers KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39864037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Performance+Tuning+of+Candidate+Determination+Methods+for+Computer+Aided+Detection+of+Colon+Polyps&rft.au=Bitter%2C+I%3BKelsey%2C+M+D%3BSummers%2C+R+M&rft.aulast=Bitter&rft.aufirst=I&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Edge-Preserving Image Smoothing on Automatic Colonic Polyp Detection for CT Colonography T2 - 2006 SPIE Meeting on Medical Imaging AN - 39863528; 4097877 JF - 2006 SPIE Meeting on Medical Imaging AU - Bitter, I AU - Pilkinton, D AU - Summers, R M AU - Campbell, S AU - Choi, J R AU - Pickhardt, P J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Polyps KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=The+Effect+of+Edge-Preserving+Image+Smoothing+on+Automatic+Colonic+Polyp+Detection+for+CT+Colonography&rft.au=Bitter%2C+I%3BPilkinton%2C+D%3BSummers%2C+R+M%3BCampbell%2C+S%3BChoi%2C+J+R%3BPickhardt%2C+P+J&rft.aulast=Bitter&rft.aufirst=I&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uterine Fibroid Segmentation and Volume Measurement in MRI T2 - 2006 SPIE Meeting on Medical Imaging AN - 39863316; 4097838 JF - 2006 SPIE Meeting on Medical Imaging AU - Yao, J AU - Chen, D AU - Lu, W. AU - Premkumar, A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Magnetic resonance imaging KW - Segmentation KW - Uterus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Uterine+Fibroid+Segmentation+and+Volume+Measurement+in+MRI&rft.au=Yao%2C+J%3BChen%2C+D%3BLu%2C+W.%3BPremkumar%2C+A&rft.aulast=Yao&rft.aufirst=J&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Proteomics, the BCL-2/BAX Switch, and the Role of the Pathologist T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39862730; 4102319 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Feldman, A L AU - Espina, V AU - Gulmann, C AU - Winters, M AU - Liotta, L A AU - Jaffe, E S Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Bcl-2 protein KW - Bax protein KW - Proteomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Tissue+Proteomics%2C+the+BCL-2%2FBAX+Switch%2C+and+the+Role+of+the+Pathologist&rft.au=Feldman%2C+A+L%3BEspina%2C+V%3BGulmann%2C+C%3BWinters%2C+M%3BLiotta%2C+L+A%3BJaffe%2C+E+S&rft.aulast=Feldman&rft.aufirst=A&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Diagnostic Effects of Prolonged Storage on Fresh Effusion Samples T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39858022; 4101609 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Manosca, F AU - Schinstine, M AU - Fetsch, P AU - Brosky, K AU - Erickson, D AU - Wilder, A AU - Sorbara, L AU - Raffeld, M AU - Filie, A AU - Abati, A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Storage KW - Effusion KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39858022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=The+Diagnostic+Effects+of+Prolonged+Storage+on+Fresh+Effusion+Samples&rft.au=Manosca%2C+F%3BSchinstine%2C+M%3BFetsch%2C+P%3BBrosky%2C+K%3BErickson%2C+D%3BWilder%2C+A%3BSorbara%2C+L%3BRaffeld%2C+M%3BFilie%2C+A%3BAbati%2C+A&rft.aulast=Manosca&rft.aufirst=F&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endolymphatic Sac Tumorigenesis; Ultrastructural Characteristics T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39837658; 4102855 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Riley, C R AU - Vortmeyer, A AU - Oldfield, E H AU - Lonser, R AU - Salah, B AU - Abu-Asab, M AU - Tsokos, M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Tumorigenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39837658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Endolymphatic+Sac+Tumorigenesis%3B+Ultrastructural+Characteristics&rft.au=Riley%2C+C+R%3BVortmeyer%2C+A%3BOldfield%2C+E+H%3BLonser%2C+R%3BSalah%2C+B%3BAbu-Asab%2C+M%3BTsokos%2C+M&rft.aulast=Riley&rft.aufirst=C&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The spectrum of Morphologic features of Renal Tumors in Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) Syndrome: Our experience with 34 cases T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39835573; 4101901 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Merino, M J AU - Toro, J R AU - Palau, M A AU - Linehan, W M AU - Torres-Cabala, C A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Kidneys KW - Renal cell carcinoma KW - Tumors KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=The+spectrum+of+Morphologic+features+of+Renal+Tumors+in+Hereditary+Leiomyomatosis+and+Renal+Cell+Carcinoma+%28HLRCC%29+Syndrome%3A+Our+experience+with+34+cases&rft.au=Merino%2C+M+J%3BToro%2C+J+R%3BPalau%2C+M+A%3BLinehan%2C+W+M%3BTorres-Cabala%2C+C+A&rft.aulast=Merino&rft.aufirst=M&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are Some Collecting Duct Carcinomas Indeed HLRCC Tumors? T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39833270; 4101902 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Torres-Cabala, C A AU - Li Ning, E.M.L. AU - Teller, L S AU - Palau, M A AU - Linehan, W M AU - Merino, M J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Collecting duct KW - Carcinoma KW - Tumors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39833270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Are+Some+Collecting+Duct+Carcinomas+Indeed+HLRCC+Tumors%3F&rft.au=Torres-Cabala%2C+C+A%3BLi+Ning%2C+E.M.L.%3BTeller%2C+L+S%3BPalau%2C+M+A%3BLinehan%2C+W+M%3BMerino%2C+M+J&rft.aulast=Torres-Cabala&rft.aufirst=C&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Semi-Automatic Segmentation and Quantification of 3D Spinal Cord Data T2 - 2006 SPIE Meeting on Medical Imaging AN - 39831581; 4097579 JF - 2006 SPIE Meeting on Medical Imaging AU - Van Uitert, R. AU - Bitter, I AU - Butman, J A Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Spinal cord KW - Segmentation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39831581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Semi-Automatic+Segmentation+and+Quantification+of+3D+Spinal+Cord+Data&rft.au=Van+Uitert%2C+R.%3BBitter%2C+I%3BButman%2C+J+A&rft.aulast=Van+Uitert&rft.aufirst=R.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automatic Procedure to Distinguish Colonic Polyps Located on Fold vs. Not on Fold T2 - 2006 SPIE Meeting on Medical Imaging AN - 39827800; 4097596 JF - 2006 SPIE Meeting on Medical Imaging AU - Franaszek, M AU - Summers, R M AU - Pickhardt, P J AU - Choi, J R Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Polyps KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Automatic+Procedure+to+Distinguish+Colonic+Polyps+Located+on+Fold+vs.+Not+on+Fold&rft.au=Franaszek%2C+M%3BSummers%2C+R+M%3BPickhardt%2C+P+J%3BChoi%2C+J+R&rft.aulast=Franaszek&rft.aufirst=M&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MALT Lymphoma of the Dura: Analysis of Clinical, Histological and Genetic Features T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39826479; 4102350 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Rizzo, K A AU - Streubel, B AU - Chott, A AU - Sorbara, L AU - Kumar, S AU - Pittaluga, S AU - Raffeld, M AU - Jaffe, E S Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Lymphoma KW - Mucosal-associated lymphoid tissue KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=MALT+Lymphoma+of+the+Dura%3A+Analysis+of+Clinical%2C+Histological+and+Genetic+Features&rft.au=Rizzo%2C+K+A%3BStreubel%2C+B%3BChott%2C+A%3BSorbara%2C+L%3BKumar%2C+S%3BPittaluga%2C+S%3BRaffeld%2C+M%3BJaffe%2C+E+S&rft.aulast=Rizzo&rft.aufirst=K&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clonality of Borderline and Serous Carcinoma of the Ovary: Molecular Studies Identify a Monoclonal Origin for Primary Tumors and their Implants T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39823967; 4102101 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Ning, E.M.L. Li AU - Teller, L S AU - Ricketts, R.S.J. AU - Otis, C AU - Sobel, M AU - Merino, M J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Ovarian carcinoma KW - Ovaries KW - Tumors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Clonality+of+Borderline+and+Serous+Carcinoma+of+the+Ovary%3A+Molecular+Studies+Identify+a+Monoclonal+Origin+for+Primary+Tumors+and+their+Implants&rft.au=Ning%2C+E.M.L.+Li%3BTeller%2C+L+S%3BRicketts%2C+R.S.J.%3BOtis%2C+C%3BSobel%2C+M%3BMerino%2C+M+J&rft.aulast=Ning&rft.aufirst=E.M.L.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wavelet Analysis in Virtual Colonoscopy T2 - 2006 SPIE Meeting on Medical Imaging AN - 39820401; 4097878 JF - 2006 SPIE Meeting on Medical Imaging AU - Greenblum, S I AU - Li, J. AU - Huang, A AU - Summers, R M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Wave analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Wavelet+Analysis+in+Virtual+Colonoscopy&rft.au=Greenblum%2C+S+I%3BLi%2C+J.%3BHuang%2C+A%3BSummers%2C+R+M&rft.aulast=Greenblum&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterssunmon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer Aided Lytic Bone Metastasis Detection Using Regular CT Images T2 - 2006 SPIE Meeting on Medical Imaging AN - 39781787; 4097320 JF - 2006 SPIE Meeting on Medical Imaging AU - Yao, J AU - O'Connor, S D AU - Summers, R M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Bone KW - Computers KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39781787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Computer+Aided+Lytic+Bone+Metastasis+Detection+Using+Regular+CT+Images&rft.au=Yao%2C+J%3BO%27Connor%2C+S+D%3BSummers%2C+R+M&rft.aulast=Yao&rft.aufirst=J&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterstw LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeted Endo-Myocardial Injections of Stem Cells Using Fused MRI and X-ray Guidance T2 - 2006 SPIE Meeting on Medical Imaging AN - 39780332; 4097458 JF - 2006 SPIE Meeting on Medical Imaging AU - Gutierrez, L F AU - DeSilva, R AU - McVeigh, E R AU - Ozturk, C R AU - Lederman, R J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Magnetic resonance imaging KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39780332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Targeted+Endo-Myocardial+Injections+of+Stem+Cells+Using+Fused+MRI+and+X-ray+Guidance&rft.au=Gutierrez%2C+L+F%3BDeSilva%2C+R%3BMcVeigh%2C+E+R%3BOzturk%2C+C+R%3BLederman%2C+R+J&rft.aulast=Gutierrez&rft.aufirst=L&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hybrid Committee Classifiers for a Computerized Colonic Polyp Detection System T2 - 2006 SPIE Meeting on Medical Imaging AN - 39773120; 4097321 JF - 2006 SPIE Meeting on Medical Imaging AU - Li, J. AU - Yao, J AU - Petrick, N AU - Summers, R M AU - Hara, A K Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Hybrids KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Hybrid+Committee+Classifiers+for+a+Computerized+Colonic+Polyp+Detection+System&rft.au=Li%2C+J.%3BYao%2C+J%3BPetrick%2C+N%3BSummers%2C+R+M%3BHara%2C+A+K&rft.aulast=Li&rft.aufirst=J.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterstw LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automatic Colonic Polyp Detection Using Multiobjective Evolutionary Technique T2 - 2006 SPIE Meeting on Medical Imaging AN - 39766514; 4097325 JF - 2006 SPIE Meeting on Medical Imaging AU - Li, J. AU - Huang, A AU - Yao, J AU - Bitter, I AU - Summers, R M AU - Pickhardt, P J AU - Choi, J R Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Evolution KW - Polyps KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39766514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Automatic+Colonic+Polyp+Detection+Using+Multiobjective+Evolutionary+Technique&rft.au=Li%2C+J.%3BHuang%2C+A%3BYao%2C+J%3BBitter%2C+I%3BSummers%2C+R+M%3BPickhardt%2C+P+J%3BChoi%2C+J+R&rft.aulast=Li&rft.aufirst=J.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/index.cfm?fuseaction =posterstw LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Assessment of Colon Distention for Polyp Detection in CT Virtual Colonoscopy T2 - 2006 SPIE Meeting on Medical Imaging AN - 39762688; 4097598 JF - 2006 SPIE Meeting on Medical Imaging AU - Van Uitert, R. AU - Bitter, I AU - Summers, R M AU - Choi, J R AU - Pickhardt, P J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Colon KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39762688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Quantitative+Assessment+of+Colon+Distention+for+Polyp+Detection+in+CT+Virtual+Colonoscopy&rft.au=Van+Uitert%2C+R.%3BBitter%2C+I%3BSummers%2C+R+M%3BChoi%2C+J+R%3BPickhardt%2C+P+J&rft.aulast=Van+Uitert&rft.aufirst=R.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CISH@@uTM@ is a Good Technique to Determine Her2 Gene Amplification in Cytologic Preparations from Breast Carcinomas: Excellent Correlation with FFPE Tissue Analysis T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39745879; 4101552 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - Ning, E.M.L. Li AU - Palau, M A AU - Garcia-Macias, C AU - Allende, D AU - Silva, A AU - Merino, M J Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - HER2 gene KW - Breast carcinoma KW - Tumors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39745879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=CISH%40%40uTM%40+is+a+Good+Technique+to+Determine+Her2+Gene+Amplification+in+Cytologic+Preparations+from+Breast+Carcinomas%3A+Excellent+Correlation+with+FFPE+Tissue+Analysis&rft.au=Ning%2C+E.M.L.+Li%3BPalau%2C+M+A%3BGarcia-Macias%2C+C%3BAllende%2C+D%3BSilva%2C+A%3BMerino%2C+M+J&rft.aulast=Ning&rft.aufirst=E.M.L.&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Level Set Based Vertebra Segmentation for the Evaluation of Ankylosing Spondylitis T2 - 2006 SPIE Meeting on Medical Imaging AN - 39737719; 4097612 JF - 2006 SPIE Meeting on Medical Imaging AU - Tan, S AU - Yao, J AU - Ward, M M AU - Yao, L AU - Summers, R M Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Segmentation KW - Spine KW - Ankylosing spondylitis KW - Vertebrae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39737719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+SPIE+Meeting+on+Medical+Imaging&rft.atitle=Level+Set+Based+Vertebra+Segmentation+for+the+Evaluation+of+Ankylosing+Spondylitis&rft.au=Tan%2C+S%3BYao%2C+J%3BWard%2C+M+M%3BYao%2C+L%3BSummers%2C+R+M&rft.aulast=Tan&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+SPIE+Meeting+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/mi/conferences/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. AN - 67634148; 16338928 AB - Skin keratinocytes are subject to frequent chemical and physical injury and have developed elaborate cell survival mechanisms to compensate. Among these, the Akt/protein kinase B (PKB) pathway protects keratinocytes from the toxic effects of ultraviolet light (UV). In contrast, the protein kinase C (PKC) family is involved in several keratinocyte death pathways. During an examination of potential interactions among these two pathways, we found that the insulin-like growth factor (IGF-1) activates both the PKC and the Akt signaling pathways in cultured primary mouse keratinocytes as indicated by increased phospho-PKC and phospho-Ser-473-Akt. IGF-1 also selectively induced translocation of PKCdelta and PKCepsilon from soluble to particulate fractions in mouse keratinocytes. Furthermore, the PKC-specific inhibitor, GF109203X, increased IGF-1-induced phospho-Ser-473-Akt and Akt kinase activity and enhanced IGF-1 protection from UVC-induced apoptosis. Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity. TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis. The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt. Individual PKC isoforms were overexpressed in cultured keratinocytes by transduction with adenoviral vectors or inhibited with PKC-selective inhibitors. These studies indicated that PKCdelta and PKCepsilon were selectively potent at causing dephosphorylation of Akt and modifying cell survival, whereas PKCalpha enhanced phosphorylation of Akt on Ser-473. Our results suggested that activation of PKCdelta and PKCepsilon provide a negative regulation for Akt phosphorylation and kinase activity in mouse keratinocytes and serve as modulators of cell survival pathways in response to external stimuli. JF - The Journal of biological chemistry AU - Li, Luowei AU - Sampat, Keeran AU - Hu, Nancy AU - Zakari, Julia AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. lilu@mail.nih.gov Y1 - 2006/02/10/ PY - 2006 DA - 2006 Feb 10 SP - 3237 EP - 3243 VL - 281 IS - 6 SN - 0021-9258, 0021-9258 KW - Indoles KW - 0 KW - Maleimides KW - Protein Isoforms KW - Serine KW - 452VLY9402 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C-delta KW - Protein Kinase C-epsilon KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Protein Phosphatase 2 KW - bisindolylmaleimide I KW - L79H6N0V6C KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Immunoblotting KW - Ultraviolet Rays KW - Protein Kinase C-delta -- metabolism KW - Tetradecanoylphorbol Acetate -- chemistry KW - Skin -- metabolism KW - Immunoprecipitation KW - Insulin-Like Growth Factor I -- metabolism KW - Mice KW - Serine -- chemistry KW - Adenoviridae -- genetics KW - Protein Kinase C-epsilon -- metabolism KW - Skin -- radiation effects KW - Phosphorylation KW - Cells, Cultured KW - Phosphoprotein Phosphatases -- metabolism KW - Indoles -- pharmacology KW - Time Factors KW - Signal Transduction KW - Protein Transport KW - Maleimides -- pharmacology KW - Protein Kinase C -- metabolism KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Apoptosis KW - Keratinocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67634148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Protein+kinase+C+negatively+regulates+Akt+activity+and+modifies+UVC-induced+apoptosis+in+mouse+keratinocytes.&rft.au=Li%2C+Luowei%3BSampat%2C+Keeran%3BHu%2C+Nancy%3BZakari%2C+Julia%3BYuspa%2C+Stuart+H&rft.aulast=Li&rft.aufirst=Luowei&rft.date=2006-02-10&rft.volume=281&rft.issue=6&rft.spage=3237&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis. AN - 67838737; 16469093 AB - Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation spectra of the tumor suppressor that is most commonly mutated in human cancers, p53, unexpectedly suggested that somatic evolution of the p53 gene during tumorigenesis is dominated by positive selection for gain of function. This conclusion is supported by accumulating experimental evidence of evolution of new functions of p53 in tumors. These findings prompted a genome-wide analysis of possible positive selection during tumor evolution. A comprehensive analysis of probable somatic mutations in the sequences of Expressed Sequence Tags (ESTs) from malignant tumors and normal tissues was performed in order to access the prevalence of positive selection in cancer evolution. For each EST, the numbers of synonymous and non-synonymous substitutions were calculated. In order to identify genes with a signature of positive selection in cancers, these numbers were compared to: i) expected numbers and ii) the numbers for the respective genes in the ESTs from normal tissues. We identified 112 genes with a signature of positive selection in cancers, i.e., a significantly elevated ratio of non-synonymous to synonymous substitutions, in tumors as compared to 37 such genes in an approximately equal-sized EST collection from normal tissues. A substantial fraction of the tumor-specific positive-selection candidates have experimentally demonstrated or strongly predicted links to cancer. The results of EST analysis should be interpreted with extreme caution given the noise introduced by sequencing errors and undetected polymorphisms. Furthermore, an inherent limitation of EST analysis is that multiple mutations amenable to statistical analysis can be detected only in relatively highly expressed genes. Nevertheless, the present results suggest that positive selection might affect a substantial number of genes during tumorigenic somatic evolution. JF - BMC cancer AU - Babenko, Vladimir N AU - Basu, Malay K AU - Kondrashov, Fyodor A AU - Rogozin, Igor B AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda MD, USA. babenko@ncbi.nlm.nih.gov Y1 - 2006/02/09/ PY - 2006 DA - 2006 Feb 09 SP - 36 VL - 6 KW - Index Medicus KW - Sequence Analysis, Protein KW - Polymorphism, Single Nucleotide KW - Sequence Alignment KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Evolution, Molecular KW - Amino Acid Substitution KW - Genes, Neoplasm KW - Expressed Sequence Tags -- chemistry KW - Mutation KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67838737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Signs+of+positive+selection+of+somatic+mutations+in+human+cancers+detected+by+EST+sequence+analysis.&rft.au=Babenko%2C+Vladimir+N%3BBasu%2C+Malay+K%3BKondrashov%2C+Fyodor+A%3BRogozin%2C+Igor+B%3BKoonin%2C+Eugene+V&rft.aulast=Babenko&rft.aufirst=Vladimir&rft.date=2006-02-09&rft.volume=6&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-09 N1 - Date created - 2006-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1987 Apr 5;194(3):391-6 [3305960] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Proteins. 1991;9(3):180-90 [2006136] BMC Genomics. 2004 Sep 28;5:72 [15453915] Science. 1991 Jul 5;253(5015):49-53 [1905840] Nature. 1998 Dec 17;396(6712):643-9 [9872311] Cell. 2004 Dec 17;119(6):847-60 [15607980] Cell. 2004 Dec 17;119(6):861-72 [15607981] Semin Cancer Biol. 2005 Feb;15(1):51-60 [15613288] Oncogene. 2005 Apr 18;24(17):2899-908 [15838523] Cell Cycle. 2005 May;4(5):686-8 [15846083] Cancer Biol Ther. 2005 Jun;4(6):621-7 [15970666] Mol Biol Evol. 2005 Dec;22(12):2504-7 [16107590] Trends Cell Biol. 1999 Dec;9(12):M57-60 [10611684] FASEB J. 2000 Oct;14(13):1901-7 [11023974] Trends Mol Med. 2002 Apr;8(4):179-86 [11927276] Oncogene. 2002 Jul 11;21(30):4595-600 [12096336] Am J Med Genet. 2002 Jul 22;111(1):96-102 [12124744] Trends Genet. 2002 Sep;18(9):486 [12175810] Carcinogenesis. 2003 Jan;24(1):1-6 [12538342] Hum Mutat. 2003 Mar;21(3):321-6 [12619119] Gene. 2003 Jul 17;312:207-13 [12909357] Nucleic Acids Res. 2003 Oct 1;31(19):5635-43 [14500827] Cancer Res. 2003 Oct 1;63(19):6212-20 [14559806] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13418-23 [14593198] Nat Rev Cancer. 2004 Mar;4(3):177-83 [14993899] BMC Cancer. 2004 Jan 29;4:4 [15005807] Nat Med. 2004 Aug;10(8):789-99 [15286780] Biochim Biophys Acta. 2004 Aug 12;1679(2):95-106 [15297143] Nat Genet. 1993 May;4(1):42-6 [8099841] Nat Genet. 1993 Aug;4(4):332-3 [8401577] Am J Pathol. 1994 Sep;145(3):702-14 [8080050] Cell. 1997 Feb 7;88(3):323-31 [9039259] Nature. 1997 Apr 24;386(6627):761, 763 [9126728] Genes Dev. 1990 Jan;4(1):1-8 [2137806] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity. AN - 67623076; 16451080 AB - PABA/NO is a diazeniumdiolate of structure Me(2)NN(O)=NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic acid). It has shown activity against human ovarian cancer xenografts in mice rivaling that of cisplatin, but it is poorly soluble and relatively unstable in water. Here we report structure-based optimization efforts resulting in three analogues with improved solubility and stability in aqueous solution. We sought to explain PABA/NO's physicochemical uniqueness among these four compounds, whose aminobenzoic acid precursors differ structurally only in the presence or absence of the N-methyl group and/or the position of the carboxyl moiety (meta or para). Studies revealed that PABA/NO's N-methyl-p-aminobenzoic acid substituent is bound to the dinitrobenzene ring via its carboxyl oxygen while the other three are linked through the aniline nitrogen. This constitutes a revision of the previously published PABA/NO structure. All four analogues reacted with GSH to produce bioactive nitric oxide (NO), but PABA/NO was the most reactive. Consistent with PABA/NO's potent suppression of A2780 human ovarian cancer xenograft growth in mice, it was the most potent of the four in the OVCAR-3 cell line. JF - Journal of medicinal chemistry AU - Saavedra, Joseph E AU - Srinivasan, Aloka AU - Buzard, Gregory S AU - Davies, Keith M AU - Waterhouse, David J AU - Inami, Keiko AU - Wilde, Thomas C AU - Citro, Michael L AU - Cuellar, Matthew AU - Deschamps, Jeffrey R AU - Parrish, Damon AU - Shami, Paul J AU - Findlay, Victoria J AU - Townsend, Danyelle M AU - Tew, Kenneth D AU - Singh, Shivendra AU - Jia, Lee AU - Ji, Xinhua AU - Keefer, Larry K AD - Basic Research Program, SAIC Frederick, Chemistry Section, Laboratory of Comparative Carcinogenesis, and Biomolecular Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2006/02/09/ PY - 2006 DA - 2006 Feb 09 SP - 1157 EP - 1164 VL - 49 IS - 3 SN - 0022-2623, 0022-2623 KW - Antineoplastic Agents KW - 0 KW - Azo Compounds KW - O(2)-(2,4-dinitro-5-(N-methyl-N-4-carboxyphenylamino)phenyl 1-N,N-dimethylamino)diazen-1-ium-1,2-diolate KW - para-Aminobenzoates KW - Nitric Oxide KW - 31C4KY9ESH KW - Glutathione KW - GAN16C9B8O KW - 4-Aminobenzoic Acid KW - TL2TJE8QTX KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Drug Stability KW - Solubility KW - Mice, Inbred NOD KW - Humans KW - Nitric Oxide -- chemical synthesis KW - Cell Line, Tumor KW - Mice KW - 4-Aminobenzoic Acid -- chemical synthesis KW - 4-Aminobenzoic Acid -- pharmacology KW - Hydrolysis KW - Structure-Activity Relationship KW - Transplantation, Heterologous KW - Glutathione -- chemistry KW - Crystallography, X-Ray KW - Mice, SCID KW - 4-Aminobenzoic Acid -- chemistry KW - Azo Compounds -- chemical synthesis KW - Azo Compounds -- chemistry KW - Azo Compounds -- pharmacology KW - Antineoplastic Agents -- chemical synthesis KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67623076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=PABA%2FNO+as+an+anticancer+lead%3A+analogue+synthesis%2C+structure+revision%2C+solution+chemistry%2C+reactivity+toward+glutathione%2C+and+in+vitro+activity.&rft.au=Saavedra%2C+Joseph+E%3BSrinivasan%2C+Aloka%3BBuzard%2C+Gregory+S%3BDavies%2C+Keith+M%3BWaterhouse%2C+David+J%3BInami%2C+Keiko%3BWilde%2C+Thomas+C%3BCitro%2C+Michael+L%3BCuellar%2C+Matthew%3BDeschamps%2C+Jeffrey+R%3BParrish%2C+Damon%3BShami%2C+Paul+J%3BFindlay%2C+Victoria+J%3BTownsend%2C+Danyelle+M%3BTew%2C+Kenneth+D%3BSingh%2C+Shivendra%3BJia%2C+Lee%3BJi%2C+Xinhua%3BKeefer%2C+Larry+K&rft.aulast=Saavedra&rft.aufirst=Joseph&rft.date=2006-02-09&rft.volume=49&rft.issue=3&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-29 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Low Testosterone and the Risk of Anemia in Older Persons T2 - 5th World Congress on the Aging Male AN - 39895083; 4077726 JF - 5th World Congress on the Aging Male AU - Ferrucci, L AU - Maggio, M AU - Bandinelli, S AU - Basaria, S AU - Lauretani, F AU - Ble, A AU - Valenti, G AU - Ershler, W B AU - Guralnik, J M AU - Longo, D L Y1 - 2006/02/09/ PY - 2006 DA - 2006 Feb 09 KW - Anemia KW - Testosterone KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+World+Congress+on+the+Aging+Male&rft.atitle=Low+Testosterone+and+the+Risk+of+Anemia+in+Older+Persons&rft.au=Ferrucci%2C+L%3BMaggio%2C+M%3BBandinelli%2C+S%3BBasaria%2C+S%3BLauretani%2C+F%3BBle%2C+A%3BValenti%2C+G%3BErshler%2C+W+B%3BGuralnik%2C+J+M%3BLongo%2C+D+L&rft.aulast=Ferrucci&rft.aufirst=L&rft.date=2006-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+World+Congress+on+the+Aging+Male&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aging/aging5/program/session1.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The "Hormonal Dysregulation Score" and Frailty T2 - 5th World Congress on the Aging Male AN - 39752431; 4077730 DE: JF - 5th World Congress on the Aging Male AU - Maggio, M AU - Valenti, G AU - Ceda, G P AU - Cappola, A AU - Basaria, S AU - Bandinelli, S AU - Lauretani, F AU - Ferrucci, L Y1 - 2006/02/09/ PY - 2006 DA - 2006 Feb 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+World+Congress+on+the+Aging+Male&rft.atitle=The+%22Hormonal+Dysregulation+Score%22+and+Frailty&rft.au=Maggio%2C+M%3BValenti%2C+G%3BCeda%2C+G+P%3BCappola%2C+A%3BBasaria%2C+S%3BBandinelli%2C+S%3BLauretani%2C+F%3BFerrucci%2C+L&rft.aulast=Maggio&rft.aufirst=M&rft.date=2006-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+World+Congress+on+the+Aging+Male&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aging/aging5/program/session1.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complex Roles for the TGF-B Pathway in Breast Carcinogenesis T2 - 2006 Special Conference on TGF-B in Cancer and Other Diseases AN - 40137570; 4089923 JF - 2006 Special Conference on TGF-B in Cancer and Other Diseases AU - Wakefield, Lalage M Y1 - 2006/02/08/ PY - 2006 DA - 2006 Feb 08 KW - Carcinogenesis KW - Breast KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40137570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.atitle=Complex+Roles+for+the+TGF-B+Pathway+in+Breast+Carcinogenesis&rft.au=Wakefield%2C+Lalage+M&rft.aulast=Wakefield&rft.aufirst=Lalage&rft.date=2006-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page5210.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF-B: At the Crossroad Between Inflammation and Cancer T2 - 2006 Special Conference on TGF-B in Cancer and Other Diseases AN - 40115449; 4089930 JF - 2006 Special Conference on TGF-B in Cancer and Other Diseases AU - Letterio, John J Y1 - 2006/02/08/ PY - 2006 DA - 2006 Feb 08 KW - Cancer KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40115449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.atitle=TGF-B%3A+At+the+Crossroad+Between+Inflammation+and+Cancer&rft.au=Letterio%2C+John+J&rft.aulast=Letterio&rft.aufirst=John&rft.date=2006-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page5210.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Perspectives on the Complex Roles of TGF-B in Wound Healing and Cancer T2 - 2006 Special Conference on TGF-B in Cancer and Other Diseases AN - 40073592; 4089938 JF - 2006 Special Conference on TGF-B in Cancer and Other Diseases AU - Roberts, Anita B Y1 - 2006/02/08/ PY - 2006 DA - 2006 Feb 08 KW - Cancer KW - Wound healing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.atitle=New+Perspectives+on+the+Complex+Roles+of+TGF-B+in+Wound+Healing+and+Cancer&rft.au=Roberts%2C+Anita+B&rft.aulast=Roberts&rft.aufirst=Anita&rft.date=2006-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page5210.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Inhibitory Smads in Inflammation T2 - 2006 Special Conference on TGF-B in Cancer and Other Diseases AN - 40073541; 4089933 JF - 2006 Special Conference on TGF-B in Cancer and Other Diseases AU - Kim, Seong-Jin Y1 - 2006/02/08/ PY - 2006 DA - 2006 Feb 08 KW - Inflammation KW - Smad protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40073541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.atitle=Role+of+Inhibitory+Smads+in+Inflammation&rft.au=Kim%2C+Seong-Jin&rft.aulast=Kim&rft.aufirst=Seong-Jin&rft.date=2006-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+TGF-B+in+Cancer+and+Other+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page5210.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor. AN - 67641772; 16446424 AB - Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the thyroid and metastatic lesions of a mouse model of follicular thyroid carcinoma [thyroid hormone beta receptor (TRbeta)(PV/PV) mice]. This TRbeta(PV/PV) mouse harbors a knock-in mutant TRbeta gene (TRbetaPV mutant) that spontaneously develops thyroid cancer and distant metastasis similar to human follicular thyroid cancer. Here we show that in thyroid tumors, PV mutant bound significantly more to the PI3K-regulatory subunit p85alpha, resulting in a greater increase in the kinase activity than did TRbeta1 in wild-type mice. By GST pull-down assays, the ligand-binding domain of TR was identified as the interaction site with p85alpha. By confocal fluorescence microscopy, p85alpha was shown to colocalize with TRbeta1 or PV mainly in the nuclear compartment of cultured tumor cells from TRbeta(PV/PV) mice, but cytoplasmic p85alpha/PV or p85alpha/TRbeta1 complexes were also detectable. Further biochemical analysis revealed that the activation of the PI3K-AKT-mammalian target of the rapamycin-p70(S6K) pathway was observed in both the cytoplasmic and nuclear compartments, whereas the activation of the PI3K-integrin-linked kinase-matrix metalloproteinase 2 pathway was detected mainly in the extranuclear compartments. These results suggest that PV, via the activation of p85alpha, could act to affect PI3K downstream signaling in both the nuclear and extranuclear compartments, thereby contributing to thyroid carcinogenesis. Importantly, the present study unveils a mechanism by which a mutant TR acts to activate PI3K activity via protein-protein interactions. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Furuya, Fumihiko AU - Hanover, John A AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 SP - 1780 EP - 1785 VL - 103 IS - 6 SN - 0027-8424, 0027-8424 KW - Protein Subunits KW - 0 KW - Thyroid Hormone Receptors beta KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Cell Nucleus -- metabolism KW - Mice KW - Protein Subunits -- metabolism KW - Mice, Transgenic KW - Protein Binding KW - Thyroid Hormone Receptors beta -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Mutation -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67641772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Activation+of+phosphatidylinositol+3-kinase+signaling+by+a+mutant+thyroid+hormone+beta+receptor.&rft.au=Furuya%2C+Fumihiko%3BHanover%2C+John+A%3BCheng%2C+Sheue-yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2006-02-07&rft.volume=103&rft.issue=6&rft.spage=1780&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol Res Commun. 1999 May;1(2):153-7 [10356365] Biochimie. 2005 Mar-Apr;87(3-4):287-97 [15781315] Cancer Res. 2001 Aug 15;61(16):6105-11 [11507060] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] Biochim Biophys Acta. 2002 Oct 10;1584(2-3):73-80 [12385889] Thyroid. 2002 Nov;12(11):963-9 [12490073] Nat Rev Mol Cell Biol. 2003 May;4(5):349-60 [12728269] Endocr J. 2003 Feb;50(1):77-83 [12733712] Cancer Metastasis Rev. 2003 Dec;22(4):375-84 [12884912] Hum Mutat. 2003 Sep;22(3):183-98 [12938083] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] J Med Genet. 2004 Mar;41(3):161-70 [14985374] Cancer Treat Res. 2004;119:59-75 [15164873] Curr Pharm Des. 2004;10(16):1915-22 [15180528] J Clin Oncol. 2004 Jul 15;22(14):2954-63 [15254063] Curr Opin Cell Biol. 2004 Oct;16(5):565-71 [15363808] Pharmacol Res. 2004 Dec;50(6):545-9 [15501691] Curr Opin Cell Biol. 2005 Apr;17(2):141-9 [15780590] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Mol Cell Biol. 2005 Sep;25(17):7687-95 [16107715] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] J Biol Chem. 2001 Jul 6;276(27):24466-72 [11313349] Mol Endocrinol. 1991 Apr;5(4):485-92 [1922081] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] J Clin Invest. 1993 Oct;92(4):1986-93 [8408652] Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4273-7 [8633054] Nat Genet. 1997 May;16(1):64-7 [9140396] Cancer Res. 1997 Nov 1;57(21):4710-3 [9354427] Biochem J. 1998 Aug 1;333 ( Pt 3):471-90 [9677303] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Mol Endocrinol. 2005 Jan;19(1):102-12 [15388791] Nature. 2000 Sep 28;407(6803):538-41 [11029009] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protein-protein interactions for cancer therapy. AN - 67641581; 16452164 JF - Proceedings of the National Academy of Sciences of the United States of America AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068, Bethesda, MD 20892-4258, USA. curtis_harris@nih.gov Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 SP - 1659 EP - 1660 VL - 103 IS - 6 SN - 0027-8424, 0027-8424 KW - Proteins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Protein Binding KW - Polymorphism, Single Nucleotide -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics KW - Neoplasms -- prevention & control KW - Neoplasms -- therapy KW - Proteins -- metabolism KW - Proteins -- genetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67641581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Protein-protein+interactions+for+cancer+therapy.&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2006-02-07&rft.volume=103&rft.issue=6&rft.spage=1659&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2004 Feb 6;303(5659):844-8 [14704432] Genes Dev. 2004 Feb 1;18(3):306-19 [14871929] J Biol Chem. 2004 Apr 16;279(16):16000-6 [14761977] Trends Pharmacol Sci. 2004 Jul;25(7):343-6 [15219971] Science. 1991 Jul 5;253(5015):49-53 [1905840] Nature. 1992 Mar 19;356(6366):215-21 [1552940] Science. 1996 Nov 8;274(5289):948-53 [8875929] Nucleic Acids Res. 1998 Aug 1;26(15):3453-9 [9671804] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15608-12 [9861017] Nature. 2004 Nov 18;432(7015):307-15 [15549092] Cell. 2004 Nov 24;119(5):591-602 [15550242] Curr Cancer Drug Targets. 2005 Feb;5(1):3-8 [15720184] Curr Cancer Drug Targets. 2005 Feb;5(1):9-20 [15720185] Curr Top Med Chem. 2005;5(2):159-65 [15853644] J Med Chem. 2005 Jul 14;48(14):4491-9 [15999986] Cancer Res. 2005 Nov 1;65(21):9687-94 [16266988] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93 [16443686] Adv Cancer Res. 2000;77:81-137 [10549356] Nature. 2000 Nov 16;408(6810):307-10 [11099028] Nature. 2002 Jan 3;415(6867):45-53 [11780111] Comment On: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93 [16443686] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab). AN - 67636176; 16461962 AB - Pure red-cell aplasia (PRCA) is a rare hematologic disease characterized by anemia, reticulocytopenia, and absence of bone marrow erythroid precursors. Most patients respond to some form of immunosuppressive treatment, but few prospective clinical trials have been performed. To examine the efficacy of a humanized monoclonal antibody to the interleukin-2 receptor (daclizumab) for treating PRCA. Pilot study. Federal government research hospital. 15 patients with idiopathic PRCA. Daclizumab, 1 mg/kg of body weight, every 2 weeks for a total of 5 infusions. Pure red-cell aplasia was defined as transfusion-dependent anemia with a reticulocyte count of 60 x 10(9) cells/L or less and bone marrow showing absent or diminished erythroid precursors. Response to therapy was assessed by transfusion independence, increments in reticulocyte count, and nontransfused hemoglobin. Daclizumab had little toxicity. Of the 15 patients, 6 patients (40%) responded to treatment. All responders became transfusion-independent and achieved normal or near-normal hemoglobin values and normal reticulocyte counts. The study was unblinded, and the number of patients was too small to assess drug safety reliably. Daclizumab seems safe. Its efficacy in this pilot protocol suggests that expanded study in PRCA and other bone marrow failure syndromes is warranted. JF - Annals of internal medicine AU - Sloand, Elaine M AU - Scheinberg, Phillip AU - Maciejewski, Jaroslaw AU - Young, Neal S AD - Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. sloande@nih.gov Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 SP - 181 EP - 185 VL - 144 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - IL2RA protein, human KW - Immunoglobulin G KW - Immunosuppressive Agents KW - Interleukin-2 Receptor alpha Subunit KW - Receptors, Interleukin-2 KW - daclizumab KW - CUJ2MVI71Y KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Aged KW - Pilot Projects KW - Middle Aged KW - Child KW - Exanthema -- chemically induced KW - Adolescent KW - Male KW - Female KW - Immunoglobulin G -- adverse effects KW - Red-Cell Aplasia, Pure -- drug therapy KW - Receptors, Interleukin-2 -- antagonists & inhibitors KW - Antibodies, Monoclonal -- adverse effects KW - Immunosuppressive Agents -- therapeutic use KW - Immunoglobulin G -- therapeutic use KW - Immunosuppressive Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67636176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+Successful+treatment+of+pure+red-cell+aplasia+with+an+anti-interleukin-2+receptor+antibody+%28daclizumab%29.&rft.au=Sloand%2C+Elaine+M%3BScheinberg%2C+Phillip%3BMaciejewski%2C+Jaroslaw%3BYoung%2C+Neal+S&rft.aulast=Sloand&rft.aufirst=Elaine&rft.date=2006-02-07&rft.volume=144&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Surgical Funding at the National Institutes of Health T2 - First Academic Surgical Congress (AAS 2006) AN - 39837274; 4098625 JF - First Academic Surgical Congress (AAS 2006) AU - Niederhuber, John E Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 KW - Financing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39837274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=First+Academic+Surgical+Congress+%28AAS+2006%29&rft.atitle=Surgical+Funding+at+the+National+Institutes+of+Health&rft.au=Niederhuber%2C+John+E&rft.aulast=Niederhuber&rft.aufirst=John&rft.date=2006-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=First+Academic+Surgical+Congress+%28AAS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academicsurgicalcongress.org/pdffiles/2006_ASC_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen AN - 17086932; 6715002 AB - Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a marked impact on human health. C. trachomatis serovariants are the leading cause of bacterial sexually transmitted disease and infectious preventable blindness. Despite decades of effort, there is no practical vaccine against C. trachomatis diseases. Here we report that all C. trachomatis reference serotypes responsible for sexually transmitted disease and blinding trachoma synthesize a highly conserved surface-exposed antigen termed polymorphic membrane protein D (PmpD). We show that Ab specific to PmpD are neutralizing in vitro. We also present evidence that Ab against serovariable-neutralizing targets, such as the major outer membrane protein, block PmpD neutralization. This finding suggests that a decoy-like immune evasion strategy may be active in vivo whereby immunodominant type-specific surface antigens block the neutralizing ability of species-common PmpD Ab. Collectively, these results show that PmpD is a previously uncharacterized C. trachomatis species-common pan-neutralizing target. Moreover, a vaccine protocol using recombinant PmpD to elicit neutralizing Ab in the absence of immunodominant type-specific Ab might be highly efficacious and surpass the level of protection achieved through natural immunity. JF - Proceedings of the National Academy of Sciences, USA AU - Crane, Deborah D AU - Carlson, John H AU - Fischer, Elizabeth R AU - Bavoil, Patrik AU - Hsia, Ru-ching AU - Tan, Chun AU - Kuo, Cho-chou AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites and Research Technology Branch, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 SP - 1894 EP - 1899 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 6 SN - 0027-8424, 0027-8424 KW - PmpD protein KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Sexually-transmitted diseases KW - protein D KW - Chlamydia trachomatis KW - Membrane proteins KW - Pathogens KW - Blindness KW - Trachoma KW - Antibodies KW - surface antigens KW - Vaccines KW - Major outer membrane protein KW - J 02832:Antigenic properties and virulence KW - F 06100:Vaccines - active immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17086932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Chlamydia+trachomatis+polymorphic+membrane+protein+D+is+a+species-common+pan-neutralizing+antigen&rft.au=Crane%2C+Deborah+D%3BCarlson%2C+John+H%3BFischer%2C+Elizabeth+R%3BBavoil%2C+Patrik%3BHsia%2C+Ru-ching%3BTan%2C+Chun%3BKuo%2C+Cho-chou%3BCaldwell%2C+Harlan+D&rft.aulast=Crane&rft.aufirst=Deborah&rft.date=2006-02-07&rft.volume=103&rft.issue=6&rft.spage=1894&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; Serotypes; Sexually-transmitted diseases; protein D; surface antigens; Blindness; Pathogens; Membrane proteins; Vaccines; Major outer membrane protein; Trachoma; Chlamydia trachomatis ER - TY - JOUR T1 - Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus AN - 17085484; 6715000 AB - Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (K sub(d) of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro, protected mice from subsequent intranasal challenge with virulent vaccinia virus, protected mice when administered 2 days after challenge, and provided significantly greater protection than that afforded by a previously isolated rat anti-B5 mAb (19C2) or by vaccinia immune globulin. The mAb bound to a conformational epitope between amino acids 20 and 130 of B5. These chimpanzee/human anti-B5 mAbs may be useful in the prevention and treatment of vaccinia virus-induced complications of vaccination against smallpox and may also be effective in the immunoprophylaxis and immunotherapy of smallpox. JF - Proceedings of the National Academy of Sciences, USA AU - Chen, Zhaochun AU - Earl, Patricia AU - Americo, Jeffrey AU - Damon, Inger AU - Smith, Scott K AU - Zhou, Yi-Hua AU - Yu, Fujuan AU - Sebrell, Andrew AU - Emerson, Suzanne AU - Cohen, Gary AU - Eisenberg, Roselyn J AU - Svitel, Juraj AU - Schuck, Peter AU - Satterfield, William AU - Moss, Bernard AU - Purcell, Robert AD - Hepatitis Viruses Section, Molecular Hepatitis Section, Laboratory of Infectious Diseases, and Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, and Protein Biophysics Resource, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/02/07/ PY - 2006 DA - 2006 Feb 07 SP - 1882 EP - 1887 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 6 SN - 0027-8424, 0027-8424 KW - mice KW - smallpox virus KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Immunoprophylaxis KW - Immunotherapy KW - Envelopes KW - Constant region KW - Glycoproteins KW - Epitopes KW - Variola virus KW - Amino acids KW - Monoclonal antibodies KW - Globulins KW - Vaccination KW - Smallpox KW - Vaccinia virus KW - Fab KW - W3 33365:Vaccines (other) KW - F 06100:Vaccines - active immunity KW - V 22093:Antigen-antibody interaction KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17085484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Chimpanzee%2Fhuman+mAbs+to+vaccinia+virus+B5+protein+neutralize+vaccinia+and+smallpox+viruses+and+protect+mice+against+vaccinia+virus&rft.au=Chen%2C+Zhaochun%3BEarl%2C+Patricia%3BAmerico%2C+Jeffrey%3BDamon%2C+Inger%3BSmith%2C+Scott+K%3BZhou%2C+Yi-Hua%3BYu%2C+Fujuan%3BSebrell%2C+Andrew%3BEmerson%2C+Suzanne%3BCohen%2C+Gary%3BEisenberg%2C+Roselyn+J%3BSvitel%2C+Juraj%3BSchuck%2C+Peter%3BSatterfield%2C+William%3BMoss%2C+Bernard%3BPurcell%2C+Robert&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2006-02-07&rft.volume=103&rft.issue=6&rft.spage=1882&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccinia virus; Variola virus; Monoclonal antibodies; Smallpox; Amino acids; Immunotherapy; Fab; Immunoprophylaxis; Epitopes; Globulins; Constant region; Vaccination; Glycoproteins; Envelopes ER - TY - JOUR T1 - Role of mitochondrial DNA in toxic responses to oxidative stress. AN - 70682487; 15878696 AB - Mitochondria are at the crossroads of several crucial cellular activities including: adenosine triphosphate (ATP) generation via oxidative phosphorylation; the biosynthesis of heme, pyrimidines and steroids; calcium and iron homeostasis and programmed cell death (apoptosis). Mitochondria also produce considerable quantities of superoxide and hydrogen peroxide (H2O2) that in conjunction with its large iron stores can lead to a witch's brew of reactive intermediates capable of damaging macromolecules. Mitochondrial DNA (mtDNA) represents a critical target for such oxidative damage. Once damaged, mtDNA can amplify oxidative stress by decreased expression of critical proteins important for electron transport leading to a vicious cycle of reactive oxygen species (ROS) and organellar dysregulation that eventually trigger apoptosis. Oxidative stress is associated with many human disorders including: cancer, cardiovascular disease, diabetes mellitus, liver disease and neurodegenerative disease. This article reviews the evidence that oxidative damage to mtDNA can culminate in cell death and thus represents an important target for therapeutic intervention in a number of human diseases. JF - DNA repair AU - Van Houten, Bennett AU - Woshner, Victoria AU - Santos, Janine H AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA. vanhout1@niehs.nih.gov Y1 - 2006/02/03/ PY - 2006 DA - 2006 Feb 03 SP - 145 EP - 152 VL - 5 IS - 2 SN - 1568-7864, 1568-7864 KW - DNA, Mitochondrial KW - 0 KW - Oxidants KW - Reactive Oxygen Species KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - DNA Damage KW - Humans KW - Models, Biological KW - Adenosine Triphosphate -- chemistry KW - Calcium -- metabolism KW - Polymerase Chain Reaction KW - Phosphorylation KW - Cell Death KW - Oxidative Stress KW - Mitochondria -- metabolism KW - Oxidants -- metabolism KW - Mutation KW - Hydrogen Peroxide -- chemistry KW - DNA, Mitochondrial -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70682487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Role+of+mitochondrial+DNA+in+toxic+responses+to+oxidative+stress.&rft.au=Van+Houten%2C+Bennett%3BWoshner%2C+Victoria%3BSantos%2C+Janine+H&rft.aulast=Van+Houten&rft.aufirst=Bennett&rft.date=2006-02-03&rft.volume=5&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers. AN - 70679546; 16263340 AB - Analysis of the spectrum of UV-induced mutations generated in synchronized wild-type S-phase cells reveals that only approximately 25% of mutations occur at thymine (T), whilst 75% are targeted to cytosine (C). The mutational spectra changes dramatically in XP-V cells, devoid of poleta, where approximately 45% of mutations occur at Ts and approximately 55% at Cs. At the present time, it is unclear whether the C-->T mutations actually represent true misincorporations opposite C, or perhaps occur as the result of the correct incorporation of adenine (A) opposite a C in a UV-photoproduct that had undergone deamination to uracil (U). In order to assess the role that human poliota might play, if any, in the replicative bypass of such UV-photoproducts, we have analyzed the efficiency and fidelity of pol iota-dependent bypass of a T-U cyclobutane pyrimidine dimer (CPD) in vitro. Interestingly, pol iota-dependent bypass of a T-U CPD occurs more efficiently than that of a corresponding T-T CPD. Guanine (G) was misincorporated opposite the 3'U of the T-U CPD only two-fold less frequently than the correct Watson-Crick base, A. While pol iota generally extended the G:3'U-CPD mispairs less efficiently than the correctly paired primer, pol iota-dependent extension was equal to, or greater than that observed with human pols eta and kappa and S. cerevisiae pol zeta under the same assay conditions. Thus, we hypothesize that the ability of pol iota to bypass T-U CPDs through the frequent misincorporation of G opposite the 3'U of the CPD, may provide a mechanism whereby human cells can decrease the mutagenic potential of these lesions. JF - DNA repair AU - Vaisman, Alexandra AU - Takasawa, Kohei AU - Iwai, Shigenori AU - Woodgate, Roger AD - Section on DNA Replication, Repair, and Mutagenesis, Laboratory of Genomic Integrity, Building 6, Room 1A13, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-2725, USA. Y1 - 2006/02/03/ PY - 2006 DA - 2006 Feb 03 SP - 210 EP - 218 VL - 5 IS - 2 SN - 1568-7864, 1568-7864 KW - Carcinogens KW - 0 KW - DNA Primers KW - Mutagens KW - Pyrimidine Dimers KW - Uracil KW - 56HH86ZVCT KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - DNA polymerase iota KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Ultraviolet Rays KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Dose-Response Relationship, Drug KW - Humans KW - Glutathione Transferase -- metabolism KW - Xeroderma Pigmentosum -- genetics KW - Kinetics KW - Mutation KW - Time Factors KW - DNA Replication KW - Catalysis KW - DNA Primers -- chemistry KW - DNA-Directed DNA Polymerase -- physiology KW - DNA Repair KW - Uracil -- chemistry KW - Pyrimidine Dimers -- chemistry KW - DNA Damage KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70679546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=DNA+polymerase+iota-dependent+translesion+replication+of+uracil+containing+cyclobutane+pyrimidine+dimers.&rft.au=Vaisman%2C+Alexandra%3BTakasawa%2C+Kohei%3BIwai%2C+Shigenori%3BWoodgate%2C+Roger&rft.aulast=Vaisman&rft.aufirst=Alexandra&rft.date=2006-02-03&rft.volume=5&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concordance of Residual Dipolar Couplings, Backbone Order Parameters and Crystallographic B-factors for a Small alpha / beta Protein: A Unified Picture of High Probability, Fast Atomic Motions in Proteins AN - 20859055; 6710140 AB - Using ensemble refinement of the third immunoglobulin binding domain (GB3) of streptococcal protein G (a small alpha / beta protein of 56 residues), we demonstrate that backbone (N-H, N-C', C super( alpha )-H super( alpha ), C super( alpha )-C') residual dipolar coupling data in five independent alignment media, generalized order parameters from super(1) super(5)N relaxation data, and B-factors from a high-resolution (1.1A), room temperature crystal structure are entirely consistent with one another within experimental error. The optimal ensemble size representation is between four and eight, as assessed by complete cross-validation of the residual dipolar couplings. Thus, in the case of GB3, all three observables reflect the same low-amplitude anisotropic motions arising from fluctuations in backbone theta / chi torsion angles in the picosecond to nanosecond regime in both solution and crystalline environments, yielding a unified picture of fast, high-probability atomic motions in proteins. An understanding of these motions is crucial for understanding the impact of protein dynamics on protein function, since they provide part of the driving force for triggered conformational changes that occur, for example, upon ligand binding, signal transduction and enzyme catalysis. JF - Journal of Molecular Biology AU - Clore, G M AU - Schwieters, C D AD - Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA, mariusc@intra.niddk.nih.gov Y1 - 2006/02/03/ PY - 2006 DA - 2006 Feb 03 SP - 879 EP - 886 VL - 355 IS - 5 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Temperature effects KW - Data processing KW - Anisotropy KW - streptococcal protein G KW - Crystal structure KW - Enzymes KW - Signal transduction KW - Catalysis KW - Immunoglobulins KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Concordance+of+Residual+Dipolar+Couplings%2C+Backbone+Order+Parameters+and+Crystallographic+B-factors+for+a+Small+alpha+%2F+beta+Protein%3A+A+Unified+Picture+of+High+Probability%2C+Fast+Atomic+Motions+in+Proteins&rft.au=Clore%2C+G+M%3BSchwieters%2C+C+D&rft.aulast=Clore&rft.aufirst=G&rft.date=2006-02-03&rft.volume=355&rft.issue=5&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2005.11.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Anisotropy; Data processing; streptococcal protein G; Crystal structure; Enzymes; Immunoglobulins; Catalysis; Signal transduction; Streptococcus DO - http://dx.doi.org/10.1016/j.jmb.2005.11.042 ER - TY - JOUR T1 - Crystal Structure of Group A Streptococcus Mac-1: Insight into Dimer- Mediated Specificity for Recognition of Human IgG AN - 20127171; 6674797 AB - Group A Streptococcus secretes cysteine proteases named Mac-1 and Mac-2 that mediate host immune evasion by targeting both IgG and Fc receptors. Here, we report the crystal structures of Mac-1 and its catalytically inactive C94A mutant in two different crystal forms. Despite the lack of sequence homology, Mac-1 adopts the canonical papain fold. Alanine mutations at the active site confirmed the critical residues involved in a papain-like catalytic mechanism. Mac-1 forms a symmetric dimer in both crystal forms and displays the unique dimer interface among papain superfamily members. Mutations at the dimer interface resulted in a significant reduction in IgG binding and catalysis, suggesting that the dimer contributes to both IgG specificity and enzyme cooperativity. A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2. JF - Structure AU - Agniswamy, Johnson AU - Nagiec, Michal J AU - Liu, Mengyao AU - Schuck, Peter AU - Musser, James M AU - Sun, Peter D AD - Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, psun@nih.gov Y1 - 2006/02/02/ PY - 2006 DA - 2006 Feb 02 SP - 225 EP - 235 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 14 IS - 2 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Alanine KW - double prime Fc receptors KW - Papain KW - Enzymes KW - Crystals KW - Tunnels KW - Antimicrobial agents KW - Homology KW - Mac1 protein KW - Crystal structure KW - Immunoglobulin G KW - Mutation KW - Cysteine proteinase KW - Catalysis KW - Cooperativity KW - A 01340:Antibiotics & Antimicrobials KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20127171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Crystal+Structure+of+Group+A+Streptococcus+Mac-1%3A+Insight+into+Dimer-+Mediated+Specificity+for+Recognition+of+Human+IgG&rft.au=Agniswamy%2C+Johnson%3BNagiec%2C+Michal+J%3BLiu%2C+Mengyao%3BSchuck%2C+Peter%3BMusser%2C+James+M%3BSun%2C+Peter+D&rft.aulast=Agniswamy&rft.aufirst=Johnson&rft.date=2006-02-02&rft.volume=14&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2005.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - double prime Fc receptors; Alanine; Papain; Enzymes; Crystals; Tunnels; Antimicrobial agents; Homology; Mac1 protein; Immunoglobulin G; Crystal structure; Mutation; Cooperativity; Catalysis; Cysteine proteinase; Streptococcus DO - http://dx.doi.org/10.1016/j.str.2005.10.012 ER - TY - JOUR T1 - Mode of grasp, materials, and grooved chopstick tip on gripping performance and evaluation. AN - 85400133; pmid-16671604 AB - This study evaluated the effects of the mode of grasping, chopstick materials, and the groove of the chopstick-tip on gripping performance of 32 participants, among whom 16 were accustomed to using chopsticks with a pliers-grasping mode and the other 16 with a scissors-grasping mode. Based on a random sequence, 8 kinds of chopsticks with different combinations (materials: bamboo, wood, plastic, and stainless steel, with and without grooves in the chopstick-tip) were used to carry out the action of gripping two different objects (peanuts and longan). The time to finish gripping 50 pieces of peanut and longan, the number which fell on the table when gripping, the subjective effort and the subjective preference were measures of efficiency of pinching for 8 kinds of chopsticks. Analysis showed that chopstick materials significantly affect time of gripping. The large object (such as longan) could be gripped more easily with the pliers-grasping mode or gripped with the grooved chopstick-tip. However, for small objects (such as peanuts), there was no significant difference in performance whether the chopstick-tip was grooved or not. A combination of bamboo chopsticks with grooved tips used with a pliers-grasping seem preferrable for more favorable gripping performance. JF - Perceptual and motor skills AU - Ho, Cheng-Pin AU - Wu, Swei-Pi AD - Department of Industrial Management, National Pingtung University of Science and Technology, 1, Hseuh-Fu Road, Nei-Pu Hsiang, Pingtung 91201, Taiwan, ROC. cpho@mail.npust.edu.tw Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 93 EP - 103 VL - 102 IS - 1 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Cooking and Eating Utensils KW - Equipment Design KW - Female KW - *Hand Strength KW - Humans KW - Male KW - *Psychomotor Performance KW - Questionnaires KW - Semantics KW - Touch UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Mode+of+grasp%2C+materials%2C+and+grooved+chopstick+tip+on+gripping+performance+and+evaluation.&rft.au=Ho%2C+Cheng-Pin%3BWu%2C+Swei-Pi&rft.aulast=Ho&rft.aufirst=Cheng-Pin&rft.date=2006-02-01&rft.volume=102&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Speech perception and short-term memory deficits in persistent developmental speech disorder. AN - 85390194; pmid-15896836 AB - Children with developmental speech disorders may have additional deficits in speech perception and/or short-term memory. To determine whether these are only transient developmental delays that can accompany the disorder in childhood or persist as part of the speech disorder, adults with a persistent familial speech disorder were tested on speech perception and short-term memory. Nine adults with a persistent familial developmental speech disorder without language impairment were compared with 20 controls on tasks requiring the discrimination of fine acoustic cues for word identification and on measures of verbal and nonverbal short-term memory. Significant group differences were found in the slopes of the discrimination curves for first formant transitions for word identification with stop gaps of 40 and 20 ms with effect sizes of 1.60 and 1.56. Significant group differences also occurred on tests of nonverbal rhythm and tonal memory, and verbal short-term memory with effect sizes of 2.38, 1.56, and 1.73. No group differences occurred in the use of stop gap durations for word identification. Because frequency-based speech perception and short-term verbal and nonverbal memory deficits both persisted into adulthood in the speech-impaired adults, these deficits may be involved in the persistence of speech disorders without language impairment. JF - Brain and language AU - Kenney, Mary Kay AU - Barac-Cikoja, Dragana AU - Finnegan, Kimberly AU - Jeffries, Neal AU - Ludlow, Christy L AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 178 EP - 190 VL - 96 IS - 2 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Child KW - Cues KW - Female KW - Humans KW - *Language Development Disorders: epidemiology KW - Male KW - *Memory Disorders: diagnosis KW - *Memory Disorders: epidemiology KW - *Memory, Short-Term KW - Middle Aged KW - Neuropsychological Tests KW - *Speech Perception KW - Time Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85390194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Speech+perception+and+short-term+memory+deficits+in+persistent+developmental+speech+disorder.&rft.au=Kenney%2C+Mary+Kay%3BBarac-Cikoja%2C+Dragana%3BFinnegan%2C+Kimberly%3BJeffries%2C+Neal%3BLudlow%2C+Christy+L&rft.aulast=Kenney&rft.aufirst=Mary&rft.date=2006-02-01&rft.volume=96&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: Neuropsychologia. 1973 Oct;11(4):389-98[4758181]; Cites: J Speech Hear Res. 1985 Dec;28(4):556-65[4087891]; Cites: Neuropsychologia. 1974 Jan;12(1):83-93[4821193]; Cites: J Speech Hear Res. 1967 Jun;10(2):277-80[6082354]; Cites: J Speech Hear Res. 1967 Jun;10(2):348-53[6082366]; Cites: J Speech Hear Res. 1983 Dec;26(4):601-8[6199587]; Cites: J Exp Child Psychol. 1984 Apr;37(2):231-50[6726113]; Cites: J Acoust Soc Am. 1981 Feb;69(2):568-74[7462479]; Cites: J Speech Hear Res. 1993 Dec;36(6):1286-99[8114495]; Cites: J Speech Hear Res. 1996 Aug;39(4):676-86[8844549]; Cites: J Commun Disord. 1997 Sep-Oct;30(5):385-401; quiz 401-2[9309530]; Cites: Curr Opin Neurobiol. 1998 Apr;8(2):234-8[9635207]; Cites: Cereb Cortex. 2005 Feb;15(2):170-86[15238437]; Cites: J Acoust Soc Am. 1979 Dec;66(6):1703-12[521554]; Cites: Neuropsychologia. 1975 Jan;13(1):69-74[1109463]; Cites: J Speech Hear Res. 1992 Aug;35(4):819-31[1405539]; Cites: J Speech Hear Res. 1992 Feb;35(1):192-200[1735968]; Cites: J Speech Hear Disord. 1988 May;53(2):144-55[3361857]; Cites: J Speech Hear Disord. 1988 Aug;53(3):316-27[3398484]; Cites: J Speech Hear Disord. 1986 Nov;51(4):337-47[3773490]; Cites: J Speech Hear Res. 1973 Dec;16(4):721-30[4783812] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Psychogenic palatal tremor. AN - 85388665; pmid-16211603 AB - We describe a case of psychogenic palatal tremor. The diagnosis was supported by clinical criteria and neurophysiological testing, including frequency analysis and jerk-locked back-averaging. We discuss the differential diagnosis of palatal tremor as well as the role of neurophysiological testing in the diagnosis of psychogenic movement disorders.Copyright (c) 2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pirio Richardson, Sarah AU - Mari, Zoltan AU - Matsuhashi, Masao AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 274 EP - 276 VL - 21 IS - 2 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Cerebral Cortex: physiopathology KW - Diagnosis, Differential KW - Electroencephalography KW - Electromyography KW - *Essential Tremor: diagnosis KW - Essential Tremor: physiopathology KW - Essential Tremor: psychology KW - Evoked Potentials, Motor: physiology KW - Female KW - Fourier Analysis KW - Humans KW - Laryngeal Muscles: physiopathology KW - Neurologic Examination KW - *Palatal Muscles: physiopathology KW - Pharyngeal Muscles: physiopathology KW - *Psychophysiologic Disorders: diagnosis KW - Psychophysiologic Disorders: physiopathology KW - Psychophysiologic Disorders: psychology KW - Signal Processing, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85388665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Psychogenic+palatal+tremor.&rft.au=Pirio+Richardson%2C+Sarah%3BMari%2C+Zoltan%3BMatsuhashi%2C+Masao%3BHallett%2C+Mark&rft.aulast=Pirio+Richardson&rft.aufirst=Sarah&rft.date=2006-02-01&rft.volume=21&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Mapping quantitative trait loci for hearing loss in Black Swiss mice. AN - 85382528; pmid-16426780 AB - In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, and Black Swiss strains exhibited hearing profiles characteristic of progressive, sensorineural hearing impairment. In particular, CF-1, Black Swiss, and NIH Swiss mice showed early-onset hearing impairment, ICR and Swiss Webster mice expressed a delayed-onset hearing loss, and NMRI mice had normal hearing. By quantitative trait locus (QTL) mapping, two significant QTLs were identified underlying hearing loss in Black Swiss mice: one QTL mapped to chromosome (chr) 10 (named ahl5, LOD 8.9, peak association 35-42 cM) and a second QTL localized to chr 18 (ahl6, LOD 3.8, 38-44 cM). Ahl5 and ahl6 account for 61% and 32% of the variation in the backcross, respectively. Cadherin 23 (Cdh23) and protocadherin 15 (Pcdh15), mapping within the 95% confidence interval of ahl5, bear nucleotide polymorphisms in coding exons, but these appear to be unrelated to the hearing phenotype. Haplotype analyses across the Cdh23 locus demonstrated the phylogenetic relationship between Black Swiss and common inbred strains. JF - Hearing research AU - Drayton, Meghan AU - Noben-Trauth, Konrad AD - Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA. Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 128 EP - 139 VL - 212 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Analysis of Variance KW - Animals KW - Animals, Outbred Strains KW - Auditory Threshold: physiology KW - *Cadherins: genetics KW - *Chromosome Mapping: methods KW - Cluster Analysis KW - Evoked Potentials, Auditory, Brain Stem: physiology KW - Genetic Linkage KW - Genetic Predisposition to Disease KW - *Hearing Loss, Sensorineural: genetics KW - Mice KW - Normal Distribution KW - Polymorphism, Single Nucleotide KW - *Protein Precursors: genetics KW - *Quantitative Trait, Heritable UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Mapping+quantitative+trait+loci+for+hearing+loss+in+Black+Swiss+mice.&rft.au=Drayton%2C+Meghan%3BNoben-Trauth%2C+Konrad&rft.aulast=Drayton&rft.aufirst=Meghan&rft.date=2006-02-01&rft.volume=212&rft.issue=1-2&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. AN - 85301356; pmid-16472786 AB - Brain expression of CB2 cannabinoid receptors has been much less well established and characterized in comparison to the expression of brain CB1 receptors. Since CB2 receptors are intensely expressed in peripheral and immune tissues, expression in brain microglia has been anticipated. Nevertheless, we now describe expression of CB2-receptor-like immunoreactivity in brain in neuronal patterns that support broader CNS roles for this receptor. Two anti-CB2 affinity purified polyclonal antibodies were raised in rabbits immunized with peptide conjugates that corresponded to amino acids 1-33 and 20-33. Western blot analyses revealed specific bands that were identified using these sera and were absent when the sera were preadsorbed with 8.3 mug/ml of the immunizing peptides. These studies, and initial RT-PCR analyses of brain CB1 and CB2 mRNAs, also support the expression of brain CB2 receptor transcripts at levels much lower than those of CB1 receptors. CB2 cannabinoid receptor mRNA was clearly expressed in the cerebellum of wild type but not in CB2 knockout mice. CB2 immunostaining was detected in the interpolar part of spinal 5th nucleus of wild type but not in CB2 knockout mice, using a mouse C-terminal CB2 receptor antibody. Immunohistochemical analyses revealed abundant immunostaining for CB2 receptors in apparent neuronal and glial processes in a number of rat brain areas. Cerebellar Purkinje cells and hippocampal pyramidal cells revealed substantial immunoreactivity that was absent when sections were stained with preadsorbed sera. CB2 immunoreactivity was also observed in olfactory tubercle, islands of Calleja, cerebral cortex, striatum, thalamic nuclei, hippocampus, amygdala, substantia nigra, periaqueductal gray, paratrochlear nucleus, paralemniscal nucleus, red nucleus, pontine nuclei, inferior colliculus and the parvocellular portion of the medial vestibular nucleus. In-vitro, CB2 immunoreactivity was also present in hippocampal cell cultures. The multifocal expression of CB2 immunoreactivity in glial and neuronal patterns in a number of brain regions suggests reevaluation of the possible roles that CB2 receptors may play in the brain. JF - Brain Research AU - Gong Jian-Ping AU - Onaivi, Emmanuel S AU - Ishiguro Hiroki AU - Qing-Rong, Liu AU - Tagliaferro, Patricia A AU - Brusco Alicia AU - Uhl, George R AD - Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 20892, USA. PY - 2006 SP - 10 EP - 23 VL - 1071 IS - 1 SN - 0006-8993, 0006-8993 KW - Animals KW - Blotting, Northern KW - In Vitro KW - Embryo KW - Humans KW - Brain KW - Gene Expression KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Knockout KW - RNA, Messenger KW - Research Support, Non-U.S. Gov't KW - Rats KW - In Situ Hybridization KW - Brain Mapping KW - Blotting, Western KW - Rats, Sprague-Dawley KW - Comparative Study KW - Transfection KW - Receptor, Cannabinoid, CB2 KW - Immunohistochemistry KW - Cell Line KW - Research Support, N.I.H., Extramural UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85301356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Cannabinoid+CB2+receptors%3A+immunohistochemical+localization+in+rat+brain.&rft.au=Gong+Jian-Ping%3BOnaivi%2C+Emmanuel+S%3BIshiguro+Hiroki%3BQing-Rong%2C+Liu%3BTagliaferro%2C+Patricia+A%3BBrusco+Alicia%3BUhl%2C+George+R&rft.aulast=Gong+Jian-Ping&rft.aufirst=&rft.date=2006-02-01&rft.volume=1071&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Synthesis of a Phosphorylated Disaccharide Fragment of the O-Specific Polysaccharide of Vibrio cholerae O139, Functionalized for Conjugation AN - 745642538; 12882742 AB - The title disaccharide, 2-{2-{2-[(2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino]ethoxy}ethoxy } ethyl 2-O-(3,6-dideoxy-L-xylo-hexopyranosyl)-d-galactopyranoside cyclic 4,6-(potassium phosphate) (2), was synthesized from the two isomeric linker-equipped galactose acceptors 9 and 10, obtained by phosphorylation of 2-[2-(2-azidoethoxy)ethoxy]ethyl 3-O-benzyl-d-galactopyranoside (8), which were glycosylated with ethyl 2,4-di-O-benzyl-3,6-dideoxy-1-thio-l-xylo-hexopyranoside (12; Scheme). Mainly the fully protected -(1 2)-linked products 13 and 14 were formed. Catalytic hydrogenolysis/hydrogenation effected global deprotection, thereby removing the chirality at the P-atom, and simultaneously converted the azido group in the linker to an amino group ( 15). Final treatment with diethyl squarate (= 3,4-diethoxycyclobut-3-ene-1,2-dione) gave target compound 2, amenable for conjugation to proteins. JF - Helvetica Chimica Acta AU - Ruttens, Bart AU - Kovac, Pavol AD - National Institutes of Health, NIDDK, LMC, Carbohydrates, Bldg. 8, Rm. B1A25, 8 Center Drive, Bethesda, MD, 20892-0815, USA (phone: + 1 301-496-3569; fax: + 1 301-402-0589), kpn@helix.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 320 EP - 332 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 89 IS - 2 SN - 0018-019X, 0018-019X KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Galactose KW - Vibrio cholerae KW - Amino groups KW - Conjugation KW - Phosphate KW - Phosphorylation KW - Hydrogenation KW - Chirality KW - Polysaccharides KW - Disaccharides KW - J 02310:Genetics & Taxonomy KW - Q1 08425:Nutrition and feeding habits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Helvetica+Chimica+Acta&rft.atitle=Synthesis+of+a+Phosphorylated+Disaccharide+Fragment+of+the+O-Specific+Polysaccharide+of+Vibrio+cholerae+O139%2C+Functionalized+for+Conjugation&rft.au=Ruttens%2C+Bart%3BKovac%2C+Pavol&rft.aulast=Ruttens&rft.aufirst=Bart&rft.date=2006-02-01&rft.volume=89&rft.issue=2&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Helvetica+Chimica+Acta&rft.issn=0018019X&rft_id=info:doi/10.1002%2Fhlca.200690036 L2 - http://www3.interscience.wiley.com/journal/112456011/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Conjugation; Polysaccharides; Galactose; Amino groups; Phosphorylation; Phosphate; Hydrogenation; Chirality; Disaccharides; Vibrio cholerae DO - http://dx.doi.org/10.1002/hlca.200690036 ER - TY - JOUR T1 - Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells. AN - 70740750; 16435911 AB - The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1). HCT116 (TP53(+/+)), HCT15 (TP53 mutant) and TP53 null HCT116 (TP53(-/-)) cells were irradiated with gamma rays, and apoptosis was measured at various times after irradiation. In HCT116 TP53(+/+) cells, apoptosis was increased after irradiation; the increase was dependent on the time after treatment and the dose of gamma rays. However, in HCT15 TP53 mutant cells and HCT116 TP53(-/-) cells, there were no remarkable changes in apoptosis. The expression of TP53 protein in HCT116 cells was increased after irradiation and was followed by an increase in the expression of NAG1 protein. In contrast, the expression of NAG1 protein in TP53 mutant cells and TP53(-/-) cells was not increased by the radiation treatment, suggesting that NAG1 was required for apoptosis. The expression of NAG1 increased apoptosis in HCT116 cells, but radiation treatment did not further increase apoptosis. The transfection of a NAG1 siRNA into HCT116 cells suppressed radiation-induced apoptosis and inhibited the induction of NAG1 protein without altering the expression of TP53. a NAG1 luciferase promoter construct that included both of the TP53 binding sites, was activated by radiation in dose-dependent manner, while the promoters lacking one or both of the TP53 binding sites in the NAG1 promoter activity either was less responsive or did not respond. The findings reported here indicate that gamma radiation activates the TP53 tumor suppressor, which then increases the expression of NAG1. NAG1 mediates the induction of apoptosis in human colorectal cells. JF - Radiation research AU - Okazaki, Ryuji AU - Moon, Yuseok AU - Norimura, Toshiyuki AU - Eling, Thomas AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 125 EP - 130 VL - 165 IS - 2 SN - 0033-7587, 0033-7587 KW - Cytokines KW - 0 KW - GDF15 protein, human KW - Growth Differentiation Factor 15 KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Gamma Rays KW - Humans KW - HCT116 Cells KW - Dose-Response Relationship, Radiation KW - Radiation, Ionizing KW - Apoptosis -- radiation effects KW - Gene Expression Regulation, Neoplastic -- radiation effects KW - Cytokines -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70740750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Ionizing+radiation+enhances+the+expression+of+the+nonsteroidal+anti-inflammatory+drug-activated+gene+%28NAG1%29+by+increasing+the+expression+of+TP53+in+human+colon+cancer+cells.&rft.au=Okazaki%2C+Ryuji%3BMoon%2C+Yuseok%3BNorimura%2C+Toshiyuki%3BEling%2C+Thomas&rft.aulast=Okazaki&rft.aufirst=Ryuji&rft.date=2006-02-01&rft.volume=165&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-29 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. AN - 70729439; 16339075 AB - The mammalian bromodomain protein Brd4 interacts with mitotic chromosomes by binding to acetylated histone H3 and H4 and is thought to play a role in epigenetic memory. Mitotic cells are susceptible to antimicrotubule drugs. These drugs activate multiple response pathways and arrest cells at mitosis. We found that Brd4 was rapidly released from chromosomes upon treatment with antimicrotubule drugs, including the reversible agent nocodazole. Yet, when nocodazole was withdrawn, Brd4 was reloaded onto chromosomes, and cells proceeded to complete cell division. However, cells in which a Brd4 allele was disrupted (Brd4+/-), and expressing only half of the normal Brd4 levels, were defective in reloading Brd4 onto chromosomes. Consequently, Brd4+/- cells were impaired in their ability to recover from nocodazole-induced mitotic arrest: a large fraction of +/- cells failed to reach anaphase after drug withdrawal, and those that entered anaphase showed an increased frequency of abnormal chromosomal segregation. The reloading defect observed in Brd4+/- cells coincided with selective hypoacetylation of lysine residues on H3 and H4. The histone deacetylase inhibitor trichostatin A increased global histone acetylation and perturbed nocodazole-induced Brd4 unloading. Brd4 plays an integral part in a cellular response to drug-induced mitotic stress by preserving a properly acetylated chromatin status. JF - Molecular biology of the cell AU - Nishiyama, Akira AU - Dey, Anup AU - Miyazaki, Jun-Ichi AU - Ozato, Keiko AD - Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2753, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 814 EP - 823 VL - 17 IS - 2 SN - 1059-1524, 1059-1524 KW - Brd4 protein, mouse KW - 0 KW - CCNB1 protein, human KW - Ccnb1 protein, mouse KW - Chromatin KW - Cyclin B KW - Cyclin B1 KW - Histones KW - Hydroxamic Acids KW - Mutagens KW - Nuclear Proteins KW - Oncogene Proteins, Fusion KW - Transcription Factors KW - trichostatin A KW - 3X2S926L3Z KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - Nocodazole KW - SH1WY3R615 KW - Index Medicus KW - CDC2 Protein Kinase -- physiology KW - Cell Proliferation -- drug effects KW - Animals KW - Polyploidy KW - Humans KW - Mice KW - Mutagens -- pharmacology KW - Chromosome Segregation -- drug effects KW - Acetylation KW - Cyclin B -- physiology KW - Heterozygote KW - Apoptosis -- drug effects KW - Hydroxamic Acids -- pharmacology KW - Oncogene Proteins, Fusion -- physiology KW - Chromatin -- metabolism KW - Histones -- metabolism KW - Oncogene Proteins, Fusion -- genetics KW - Mitosis -- drug effects KW - Microtubules -- drug effects KW - Mitosis -- physiology KW - Nocodazole -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70729439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Brd4+is+required+for+recovery+from+antimicrotubule+drug-induced+mitotic+arrest%3A+preservation+of+acetylated+chromatin.&rft.au=Nishiyama%2C+Akira%3BDey%2C+Anup%3BMiyazaki%2C+Jun-Ichi%3BOzato%2C+Keiko&rft.aulast=Nishiyama&rft.aufirst=Akira&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=10591524&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-07 N1 - Date created - 2006-01-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Cell Biol. 2001 Feb;3(2):114-20 [11175742] Nat Cell Biol. 2001 Jan;3(1):E3-6 [11146636] Nat Rev Mol Cell Biol. 2001 Jan;2(1):21-32 [11413462] J Biol Chem. 2001 Oct 12;276(41):38307-19 [11479283] Mol Cell Biol. 2002 Jun;22(11):3794-802 [11997514] Curr Biol. 2002 Apr 30;12(9):R331-3 [12007436] Mol Cell. 2002 May;9(5):931-43 [12049731] Mol Cell Biol. 2002 Sep;22(18):6509-20 [12192049] Cell. 2003 Feb 21;112(4):407-21 [12600307] Mol Biol Cell. 2003 Mar;14(3):1043-57 [12631722] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8758-63 [12840145] Mol Biol Cell. 2003 Sep;14(9):3821-33 [12972566] Oncogene. 2003 Dec 8;22(56):9075-86 [14663486] Mol Cell. 2004 Jan 16;13(1):33-43 [14731392] Nat Rev Cancer. 2004 Apr;4(4):253-65 [15057285] Trends Cell Biol. 2004 Jun;14(6):279-81 [15183183] J Cell Biol. 2004 Aug 16;166(4):517-26 [15302851] Biol Reprod. 2004 Sep;71(3):740-8 [15115722] Exp Cell Res. 1987 Nov;173(1):85-98 [3678386] Nucleic Acids Res. 1992 May 25;20(10):2603 [1350857] Genes Dev. 1993 Apr;7(4):592-604 [8458576] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4303-7 [8183905] J Cell Biol. 1994 Oct;127(2):303-18 [7929577] Bioessays. 1995 May;17(5):423-30 [7786288] EMBO J. 1996 Jul 1;15(13):3394-402 [8670841] Genes Dev. 1996 Oct 1;10(19):2389-400 [8843192] Curr Opin Cell Biol. 1996 Dec;8(6):773-80 [8939672] Trends Biochem Sci. 1997 Jun;22(6):197-202 [9204705] Curr Opin Cell Biol. 1997 Dec;9(6):807-14 [9425345] J Biol Chem. 1998 Feb 27;273(9):4928-36 [9478937] Science. 1998 Apr 24;280(5363):599-602 [9554853] Dev Cell. 2004 Nov;7(5):637-51 [15525526] J Biol Chem. 2005 Apr 29;280(17):16994-7004 [15687487] Mol Cell. 2005 Aug 19;19(4):523-34 [16109376] Nat Cell Biol. 1999 Jun;1(2):82-7 [10559878] Mutagenesis. 1999 Nov;14(6):563-8 [10567031] Mol Cell Biol. 1999 Dec;19(12):8469-78 [10567572] Nat Genet. 2000 Apr;24(4):372-6 [10742100] Nature. 2000 Jul 27;406(6794):430-5 [10935642] Mol Cell Biol. 2000 Sep;20(17):6537-49 [10938129] Nat Cell Biol. 2001 Jan;3(1):E17-21 [11146645] J Cell Biol. 2001 Apr 30;153(3):517-27 [11331303] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin. AN - 70725452; 16449797 AB - Unregulated microglial activation has been implicated as a pivotal factor contributing to Parkinson's disease. Using mesencephalic neuron-glia cultures, we address the novel possibility that peptides endogenous to the substantia nigra (SN), substance P and dynorphin (10(-13)-10(-14) M), are opposing mediators of microglial activation and consequent DA neurotoxicity. Here, we identify that substance P (10(-13)-10(-14) M) is selectively toxic to DA neurons in a microglia-dependent manner. Mechanistically, substance P (10(-13)-10(-14) M) activated microglial NADPH oxidase to produce extracellular superoxide and intracellular reactive oxygen species (ROS). Neuron-glia cultures from mice lacking a functional NADPH oxidase complex (PHOX-/-) were insensitive to substance P (10(-13)-10(-14) M) -induced loss of DA neuron function. Mixed glia cultures from (PHOX-/-) mice failed to show a significant increase in intracellular ROS in response to substance P compared with control cultures (PHOX+/+). Further, dynorphin (10(-14) M) inhibited substance P (10(-13) M) -induced loss of [3H] DA uptake. Here we demonstrate a tightly regulated mechanism governing microglia-derived oxidative stress, where the neuropeptide balance of dynorphin and substance P is critical to DA neuron survival. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Block, M L AU - Li, G AU - Qin, L AU - Wu, X AU - Pei, Z AU - Wang, T AU - Wilson, B AU - Yang, J AU - Hong, J S AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Block@niehs.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 251 EP - 258 VL - 20 IS - 2 KW - Reactive Oxygen Species KW - 0 KW - Substance P KW - 33507-63-0 KW - Dynorphins KW - 74913-18-1 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - NADPH Oxidase -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mice KW - Male KW - Female KW - Gene Deletion KW - Substance P -- pharmacology KW - Neurons -- drug effects KW - Neurons -- cytology KW - Oxidative Stress -- drug effects KW - Dopamine -- metabolism KW - Microglia -- drug effects KW - Substance P -- toxicity KW - Neurons -- pathology KW - Microglia -- metabolism KW - Dynorphins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70725452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Potent+regulation+of+microglia-derived+oxidative+stress+and+dopaminergic+neuron+survival%3A+substance+P+vs.+dynorphin.&rft.au=Block%2C+M+L%3BLi%2C+G%3BQin%2C+L%3BWu%2C+X%3BPei%2C+Z%3BWang%2C+T%3BWilson%2C+B%3BYang%2C+J%3BHong%2C+J+S&rft.aulast=Block&rft.aufirst=M&rft.date=2006-02-01&rft.volume=20&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-15 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. AN - 70723574; 16290023 AB - Smads2 and 3 transduce signals of TGF-beta from the cell surface to the nucleus. We used mice with a targeted deletion of Smad3 to study the specific contributions of this signaling pathway to pathogenic effects of TGF-beta. Focusing on models involving epithelial-to-mesenchymal transition (EMT), including injury to the lens and retina of the eye and to the kidney, we have found that loss of Smad3 blocks EMT and attenuates development of fibrotic sequelae. Smad3 also plays a critical role in both the tumor suppressor and pro-metastatic effects of TGF-beta in carcinogenesis. These observations suggest that development of small molecule inhibitors of Smad3 might have clinical application in treatment of fibrotic diseases as well as late stage cancers. JF - Cytokine & growth factor reviews AU - Roberts, Anita B AU - Tian, Fang AU - Byfield, Stacey DaCosta AU - Stuelten, Christina AU - Ooshima, Akira AU - Saika, Shizuya AU - Flanders, Kathleen C AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. Robertsa@dce41.nci.nih.gov PY - 2006 SP - 19 EP - 27 VL - 17 IS - 1-2 SN - 1359-6101, 1359-6101 KW - Smad3 Protein KW - 0 KW - Transforming Growth Factor beta KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Cell Membrane -- immunology KW - Cell Differentiation -- physiology KW - Cell Nucleus -- metabolism KW - Humans KW - Cell Nucleus -- immunology KW - Fibrosis -- metabolism KW - Cell Membrane -- metabolism KW - Epithelial Cells -- metabolism KW - Transforming Growth Factor beta -- physiology KW - Mesoderm -- cytology KW - Neoplasms -- prevention & control KW - Neoplasm Metastasis -- pathology KW - Transforming Growth Factor beta -- genetics KW - Smad3 Protein -- physiology KW - Mesoderm -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine+%26+growth+factor+reviews&rft.atitle=Smad3+is+key+to+TGF-beta-mediated+epithelial-to-mesenchymal+transition%2C+fibrosis%2C+tumor+suppression+and+metastasis.&rft.au=Roberts%2C+Anita+B%3BTian%2C+Fang%3BByfield%2C+Stacey+DaCosta%3BStuelten%2C+Christina%3BOoshima%2C+Akira%3BSaika%2C+Shizuya%3BFlanders%2C+Kathleen+C&rft.aulast=Roberts&rft.aufirst=Anita&rft.date=2006-02-01&rft.volume=17&rft.issue=1-2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Cytokine+%26+growth+factor+reviews&rft.issn=13596101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2006-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients. AN - 70723207; 16449681 AB - Treatments for Hodgkin lymphoma are associated with large relative risks of acute myeloid leukemia (AML), but there are few estimates of the excess absolute risk (EAR), a useful measure of disease burden. One-year Hodgkin lymphoma survivors (N = 35,511) were identified within 14 population-based cancer registries in Nordic countries and North America from January 1, 1970, through December 31, 2001. We used Poisson regression analysis to model the EAR of AML, per 10,000 person-years. A total of 217 Hodgkin lymphoma survivors were diagnosed with AML (10.8 expected; unadjusted EAR = 6.2; 95% confidence interval = 5.4 to 7.1). Excess absolute risk for AML was highest during the first 10 years after Hodgkin lymphoma diagnosis but remained elevated thereafter. In subsequent analyses, adjusted for time since Hodgkin lymphoma diagnosis and presented for the 5-9 year interval, the EAR was statistically significantly (P or = 35 age groups, respectively), which may be associated with modifications in chemotherapy. JF - Journal of the National Cancer Institute AU - Schonfeld, Sara J AU - Gilbert, Ethel S AU - Dores, Graça M AU - Lynch, Charles F AU - Hodgson, David C AU - Hall, Per AU - Storm, Hans AU - Andersen, Aage AU - Pukkala, Eero AU - Holowaty, Eric AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fosså, Sophie D AU - Allan, James M AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 215 EP - 218 VL - 98 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - SEER Program KW - Poisson Distribution KW - Research Design KW - Risk Assessment KW - Antineoplastic Agents -- adverse effects KW - Registries KW - North America -- epidemiology KW - Adult KW - Confounding Factors (Epidemiology) KW - Incidence KW - Ontario -- epidemiology KW - Middle Aged KW - Scandinavian and Nordic Countries -- epidemiology KW - Finland -- epidemiology KW - Female KW - Male KW - Neoplasms, Second Primary -- epidemiology KW - Leukemia, Myeloid, Acute -- epidemiology KW - Leukemia, Myeloid, Acute -- chemically induced KW - Hodgkin Disease -- drug therapy KW - Hodgkin Disease -- therapy KW - Neoplasms, Second Primary -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Acute+myeloid+leukemia+following+Hodgkin+lymphoma%3A+a+population-based+study+of+35%2C511+patients.&rft.au=Schonfeld%2C+Sara+J%3BGilbert%2C+Ethel+S%3BDores%2C+Gra%C3%A7a+M%3BLynch%2C+Charles+F%3BHodgson%2C+David+C%3BHall%2C+Per%3BStorm%2C+Hans%3BAndersen%2C+Aage%3BPukkala%2C+Eero%3BHolowaty%2C+Eric%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFoss%C3%A5%2C+Sophie+D%3BAllan%2C+James+M%3BTravis%2C+Lois+B&rft.aulast=Schonfeld&rft.aufirst=Sara&rft.date=2006-02-01&rft.volume=98&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. AN - 70713760; 16388523 AB - Prostate carcinoma (PCa) is one of the most common malignancies in men. Androgen-deprivation therapy (ADT) is used frequently in the treatment of recurrent and metastatic PCa, rendering these men hypogonadal. Because male hypogonadism is associated with an unfavorable metabolic profile, and men with PCa have high cardiovascular mortality, the authors evaluated the effects of long-term ADT on fasting glucose levels, insulin levels, and insulin resistance. To evaluate the long-term effects of ADT on fasting glucose and insulin resistance in men with PCa who received ADT and to determine whether these metabolic alterations are a result of hypogonadism, the authors conducted a cross-sectional study at a university-based research institution in the United States. In total, 53 men were evaluated, including 18 men with PCa who received ADT for at least 12 months prior to the onset of the study (the ADT group), 17 age-matched men with nonmetastatic PCa who had undergone prostatectomy and/or received radiotherapy and who were not receiving ADT (the non-ADT group), and 18 age-matched controls (the control group). None of the men had a known history of diabetes mellitus. The mean age was similar in all 3 groups (P=0.33). Serum total testosterone levels (P<0.0001) and free testosterone levels (P<0.0001) were significantly lower in the ADT group compared with the other groups. Men in the ADT group had a higher BMI compared with the other groups (overall P=0.005). After adjustment for age and BMI, men in the ADT group had significantly higher fasting levels of the following parameters: 1) Glucose levels were 131.0+/-7.43 mg/dL in the ADT group compared with 103.0+/-7.42 mg/dL in the non-ADT group (P=0.01) and 99.0+/-7.58 mg/dL in the control group (P<0.01). 2) Insulin levels were 45.0+/-7.25 uU/mL in the ADT group compared with 24.0+/-7.24 uU/mL in the non-ADT group (P=0.05) and 19.0+/-7.39 uU/mL in the control group (P=0.02). 3) Leptin levels were 25.0+/-2.57 ng/mL in the ADT group compared with 12.0+/-2.56 ng/mL in the non-ADT group (P<0.01) and 6.0+/-2.62 ng/mL in the control group (P<0.01). 4) The homeostatic model assessment for insulin resistance (HOMAIR)=17.0+/-2.78 in the ADT group compared with HOMAIR=6.0+/-2.77 in the non-ADT group (P<0.01) and HOMAIR=5.0+/-2.83 in the control group (P=0.01). There was a significant negative correlation between total and free testosterone levels with fasting glucose, insulin, leptin, and HOMAIR. The current data suggested that men with PCa who are receiving long-term ADT are at risk for developing insulin resistance and hyperglycemia, thus leading to their increased risk of cardiovascular disease. This adverse metabolic profile developed independent of age and BMI and appeared to be a direct result of androgen deprivation. Copyright (c) 2005 American Cancer Society. JF - Cancer AU - Basaria, Shehzad AU - Muller, Denis C AU - Carducci, Michael A AU - Egan, Josephine AU - Dobs, Adrian S AD - Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, and National Institut on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. sbasari1@jhmi.edu Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 581 EP - 588 VL - 106 IS - 3 SN - 0008-543X, 0008-543X KW - Androgen Antagonists KW - 0 KW - Blood Glucose KW - Hypoglycemic Agents KW - Insulin KW - Abridged Index Medicus KW - Index Medicus KW - Cross-Sectional Studies KW - Cardiovascular Diseases -- etiology KW - Combined Modality Therapy KW - Risk Factors KW - Insulin -- blood KW - Humans KW - Case-Control Studies KW - Aged KW - Hypoglycemic Agents -- blood KW - Body Mass Index KW - Blood Glucose -- analysis KW - Male KW - Prostatic Neoplasms -- pathology KW - Androgen Antagonists -- adverse effects KW - Carcinoma -- pathology KW - Hyperglycemia -- chemically induced KW - Carcinoma -- radiotherapy KW - Carcinoma -- drug therapy KW - Prostatic Neoplasms -- drug therapy KW - Insulin Resistance KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70713760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Hyperglycemia+and+insulin+resistance+in+men+with+prostate+carcinoma+who+receive+androgen-deprivation+therapy.&rft.au=Basaria%2C+Shehzad%3BMuller%2C+Denis+C%3BCarducci%2C+Michael+A%3BEgan%2C+Josephine%3BDobs%2C+Adrian+S&rft.aulast=Basaria&rft.aufirst=Shehzad&rft.date=2006-02-01&rft.volume=106&rft.issue=3&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. AN - 70708285; 16435293 AB - A major protective mechanism against oxidizing substances capable of damaging DNA integrity and initiating carcinogenesis is the induction of phase II detoxification and antioxidant enzymes by chemopreventive agents. A key finding in the field of chemoprevention has been the discovery that the induction of these enzymes is mediated by the cytoplasmic oxidative stress system (Nrf2-Keap1). Under basal (reducing) conditions, Keap1 anchors the Nrf2 transcription factor within the cytoplasm, targeting it for ubiquitination and proteasome degradation, thus repressing its ability to induce phase II genes. When cells are exposed to chemopreventive agents and oxidative stress, however, a signal involving phosphorylation and/or redox modification is transmitted to the Nrf2-Keap1 complex, leading to its dissociation and the nuclear translocation of Nrf2, which, after hetero-dimerically partnering with other transcription factors, binds to the AREs/EpREs present within phase II gene promoters, increasing their transcription. These data should assist in developing new phase II detoxification enzyme inducers as cancer chemopreventive agents within the clinical environment. JF - BioEssays : news and reviews in molecular, cellular and developmental biology AU - Giudice, Aldo AU - Montella, Maurizio AD - G. Pascale Foundation National Cancer Institute, Unit of Epidemiology and Prevention, Naples, Italy. aldo.giudice@libero.it Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 169 EP - 181 VL - 28 IS - 2 SN - 0265-9247, 0265-9247 KW - Antioxidants KW - 0 KW - NF-E2-Related Factor 2 KW - Index Medicus KW - Animals KW - Antioxidants -- metabolism KW - Humans KW - Oxidative Stress KW - Signal Transduction -- drug effects KW - NF-E2-Related Factor 2 -- genetics KW - NF-E2-Related Factor 2 -- chemistry KW - Neoplasms -- prevention & control KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70708285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.atitle=Activation+of+the+Nrf2-ARE+signaling+pathway%3A+a+promising+strategy+in+cancer+prevention.&rft.au=Giudice%2C+Aldo%3BMontella%2C+Maurizio&rft.aulast=Giudice&rft.aufirst=Aldo&rft.date=2006-02-01&rft.volume=28&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.issn=02659247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake. AN - 70700185; 16282520 AB - Metallothioneins (MTs) are cytoplasmic proteins that sequester certain divalent cations and are considered a primary cellular defense against the toxic transition metal cadmium (Cd(2+)). MT-I/II(-/-) knockout [MT(-/-)] cells are available and serve as an excellent tool to study non-MT-related mechanisms in metal tolerance. In the current study, Cd(2+)-resistant MT(-/-) (CdR) and CdR revertant (CdR-rev) cell lines were developed and characterized to investigate non-MT-mediated cellular protection mechanisms. Resistance to Cd(2+) was approximately 70-fold higher in CdR than the parental MT(-/-) cell line (IC(50) = 20 versus 0.3 microM, respectively) and was stable in the absence of Cd(2+) for 35 days. Accumulation of Cd(2+) by the CdR cell line was reduced by approximately 95% compared with parental cells, primarily because of a decreased Cd(2+) uptake. Cd(2+) uptake by the MT(-/-) parental cell line was independent of sodium, energy, and electrogenic potential. Uptake was saturable (K(m) = 65 nM; V(max) = 4.9 pmol/mg/min) and pH-dependent (maximal at pH 6.5-7). Potent inhibitors of Cd(2+) uptake included Zn(2+) (IC(50) = 7 microM), Mn(2+) (IC(50) = 0.4 microM), and the T-type Ca(2+) channel antagonist mibefradil (IC(50) = 5 microM), whereas other metals (including Fe(2+)) and L-type Ca(2+) channel antagonists had little effect. Immunoblot and real-time reverse transcription-polymerase chain reaction analysis indicated that the Cacnalpha(1G) T-type Ca(2+) channel was expressed at a reduced level in CdR compared with the parental MT(-/-) cell line, suggesting it is important for Cd(2+) uptake. The CdR1-rev cell line was found to have a Cd(2+) uptake and sensitivity level in between that of the CdR1 and MT(-/-) cell lines. Consistent with this was an intermediate expression of Cacnalpha(1G) in the CdR-rev cell line. These data suggest that decreased expression of Cacnalpha(1G) protects cells from Cd(2+) exposure by limiting Cd(2+) uptake. JF - Molecular pharmacology AU - Leslie, Elaine M AU - Liu, Jie AU - Klaassen, Curtis D AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 629 EP - 639 VL - 69 IS - 2 SN - 0026-895X, 0026-895X KW - Cacna1g protein, mouse KW - 0 KW - Calcium Channel Blockers KW - Calcium Channels, T-Type KW - Cation Transport Proteins KW - Chloride-Bicarbonate Antiporters KW - Iron-Binding Proteins KW - Metals KW - Slc39a8 protein, mouse KW - Slc4a9 protein, mouse KW - solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 KW - Cadmium KW - 00BH33GNGH KW - Aquaporin 1 KW - 146410-94-8 KW - Metallothionein KW - 9038-94-2 KW - Sodium KW - 9NEZ333N27 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Iron-Binding Proteins -- metabolism KW - Animals KW - Chloride-Bicarbonate Antiporters -- genetics KW - Fibroblasts -- drug effects KW - Metals -- pharmacology KW - Ion Transport -- drug effects KW - Aquaporin 1 -- metabolism KW - Calcium -- chemistry KW - Metallothionein -- genetics KW - Mice KW - Cation Transport Proteins -- genetics KW - Fibroblasts -- metabolism KW - Sodium -- pharmacology KW - Mice, Knockout KW - Calcium -- metabolism KW - Chloride-Bicarbonate Antiporters -- metabolism KW - Aquaporin 1 -- genetics KW - Calcium Channel Blockers -- pharmacology KW - Ion Transport -- genetics KW - Iron-Binding Proteins -- genetics KW - Cation Transport Proteins -- metabolism KW - Sodium -- metabolism KW - Calcium Channels, T-Type -- genetics KW - Drug Resistance -- physiology KW - Cadmium -- pharmacology KW - Drug Resistance -- genetics KW - Calcium Channels, T-Type -- physiology KW - Calcium Channels, T-Type -- drug effects KW - Cadmium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70700185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Acquired+cadmium+resistance+in+metallothionein-I%2FII%28-%2F-%29+knockout+cells%3A+role+of+the+T-type+calcium+channel+Cacnalpha1G+in+cadmium+uptake.&rft.au=Leslie%2C+Elaine+M%3BLiu%2C+Jie%3BKlaassen%2C+Curtis+D%3BWaalkes%2C+Michael+P&rft.aulast=Leslie&rft.aufirst=Elaine&rft.date=2006-02-01&rft.volume=69&rft.issue=2&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-10 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice. AN - 70697979; 16428776 AB - Bacillus anthracis lethal toxin (LT) is a bipartite toxin composed of protective antigen (PA) and lethal factor (LF). Injection of LT produces clinical signs characteristic of anthrax infection, including pleural edema and vascular collapse in various animal models. We utilized the classic Miles leakage assay to quantify vascular leakage in mice. LT injected intradermally induced leakage as early as 15 to 25 min in some inbred mouse strains, but not in others, whereas PA or LF individually did not induce leakage. A third component of anthrax toxin, edema factor, did not induce leakage alone or with PA. Leakage was quantified in eight mouse strains, and no correlation was found between sensitivity to intradermal leakage and sensitivity to the lethality of systemically administered LT. The leakage could be inhibited by ketotifen, an inhibitor of mast cell degranulation, but not by azelastine, a histamine receptor 1 antagonist, or by ketanserin, a serotonin 5-HT2A receptor antagonist. LT was cytotoxic to MC/9 mast cells (in vitro) by 7 h after toxin treatment but did not induce histamine release from these cells. Mast cell-deficient mice exhibited the leakage event and had no increased resistance to systemic LT. Human umbilical vein endothelial cells were resistant to LT over 12 h, with only 20% of cells succumbing by 24 h, suggesting that endothelial cell killing is not the cause of the rapid LT-mediated leakage event. We describe here a ketotifen-sensitive vascular leakage event induced by LT which is the most rapid in vivo or in vitro LT-mediated effect reported to date. JF - Infection and immunity AU - Gozes, Yehoshua AU - Moayeri, Mahtab AU - Wiggins, Jason F AU - Leppla, Stephen H AD - Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 1266 EP - 1272 VL - 74 IS - 2 SN - 0019-9567, 0019-9567 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Histamine H1 Antagonists KW - anthrax toxin KW - Ketotifen KW - X49220T18G KW - Index Medicus KW - Mice, Inbred Strains KW - Endothelial Cells -- drug effects KW - Animals KW - Bacillus anthracis -- pathogenicity KW - Umbilical Veins KW - Bacillus anthracis -- metabolism KW - Histamine Release KW - Mice KW - Mast Cells KW - Species Specificity KW - Antigens, Bacterial -- toxicity KW - Histamine H1 Antagonists -- pharmacology KW - Capillary Permeability -- drug effects KW - Bacterial Toxins -- toxicity KW - Skin -- blood supply KW - Ketotifen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70697979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Anthrax+lethal+toxin+induces+ketotifen-sensitive+intradermal+vascular+leakage+in+certain+inbred+mice.&rft.au=Gozes%2C+Yehoshua%3BMoayeri%2C+Mahtab%3BWiggins%2C+Jason+F%3BLeppla%2C+Stephen+H&rft.aulast=Gozes&rft.aufirst=Yehoshua&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-22 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1962 Dec 21;138(3547):1331-3 [14033353] J Bacteriol. 1962 Jun;83:1274-80 [13866126] Ann Allergy Asthma Immunol. 1996 May;76(5):469-75 [8630722] Clin Cancer Res. 2000 Mar;6(3):957-65 [10741721] J Anat. 2001 Apr;198(Pt 4):399-406 [11327202] Mod Pathol. 2001 May;14(5):482-95 [11353060] Genes Dev. 2001 Oct 15;15(20):2687-701 [11641275] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Radiology. 2002 Feb;222(2):305-12 [11818592] Curr Top Med Chem. 2002 Jun;2(6):539-58 [12052193] Clin Allergy Immunol. 2002;17:287-317 [12113221] Am J Pathol. 2003 Aug;163(2):701-9 [12875989] Lab Invest. 2003 Aug;83(8):1201-9 [12920249] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] AJR Am J Roentgenol. 2003 Oct;181(4):1071-8 [14500233] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Infect Immun. 2004 Jan;72(1):430-9 [14688124] Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R699-709 [14715494] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] J Infect Dis. 1966 Apr;116(2):123-38 [4956203] J Infect Dis. 1966 Jun;116(3):377-89 [4957317] Arch Pathol. 1967 Feb;83(2):154-61 [6019568] Fed Proc. 1967 Sep;26(5):1554-7 [6051334] J Infect Dis. 1968 Feb;118(1):114-24 [5640983] Nature. 1978 Mar 9;272(5649):168-71 [564466] Blood. 1978 Aug;52(2):447-52 [352443] Infect Immun. 1984 Sep;45(3):761-7 [6432700] Am J Med Genet. 1984 Aug;18(4):621-41 [6385709] Biomed Biochim Acta. 1988;47(10-11):S289-92 [3150272] Arzneimittelforschung. 1989 Oct;39(10A):1331-5 [2483312] Drugs. 1990 Sep;40(3):412-48 [2226222] J Allergy Clin Immunol. 1990 Oct;86(4 Pt 2):684-6 [1977785] Ann N Y Acad Sci. 1992;664:69-88 [1280935] Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2291-4 [8460135] Lab Invest. 1995 Nov;73(5):691-702 [7474943] Eur J Pharmacol. 1996 Mar 7;298(2):149-54 [8867102] Mol Med. 1998 Feb;4(2):87-95 [9508786] Br J Pharmacol. 1998 Apr;123(7):1325-30 [9579726] Br J Pharmacol. 1999 Oct;128(3):700-4 [10516651] Infect Immun. 2005 Jul;73(7):4238-44 [15972515] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study. AN - 70694778; 16284058 AB - 7-Hydroxystaurosporine (UCN-01) inhibits serine-threonine kinases including the Ca2+ and phospholipid-dependent protein kinase C (PKC), CDKs 2, 4, 6, Chk-1 and PDK1. UCN-01 mediates distinct effects in vitro/in vivo: cell cycle arrest in G1, abrogation of G2 arrest by inhibiting chk1, induction of apoptosis and potentiation of cytotoxicity of S-phase-active chemotherapeutics including the topoisomerase 1 inhibitor topotecan (T). This phase I study was designed to determine the maximal tolerated dose (MTD), recommended phase 2 dose (RPTD), toxicity profile, pharmacokinetics and antitumor activity of T and UCN-01 in patients with refractory solid tumors. Both agents were administered every 21 days intravenously through central venous access in escalating doses to eligible patients. On day 1, following antiemetic prophylaxis with dexamethasone and a serotonin type 3(A) receptor (5HT3) inhibitor, UCN-01 was infused over 3 h, followed by T infused over 30 min. On days 2-5, patients received T only. UCN-01 doses were reduced by 50% in cycles 2 and beyond because of its prolonged half-life. Thirty-three patients were entered in three cohorts: Dose Level (DL) 1 (UCN-01 70 mg/m2, T 0.75 mg/m2), three patients; DL 2 (UCN-01 70 mg/m2, T 1.0 mg/m2), 24 patients; DL 3 (UCN-01 90 mg/m2, T 1.0 mg/m2), six patients. All but three patients were PS 0 or 1, median age was 54 years (range, 29-72), 91% were female. Primary tumor types: ovary/peritoneal (23 patients), colon (three patients), salivary gland (two patients), others (five patients). All patients were eligible for adverse event (AE) analysis and 22 patients were eligible for survival and tumor response analysis. Two of six patients had dose limiting toxicity (DLT) at DL 3 (grade 3 N/V; grade 4 neutropenia with infection). One DLT was seen in one patient at DL 2, consisting of grade 4 leukopenia. This cohort was expanded and no further DLTs were observed. Most common drug-related AEs were mild (grade 1-2). Non-hematological grade 3-4 AEs consisted of transient hyperglycemia (4), infection (3), coagulation, fatigue, hypotension, nausea (2), hypomagnesemia, vomiting, headache (1). Hematologic toxicities occurred in 100% of patients. Grade 3-4 hematologic abnormalities included neutropenia (16, including three with infection), leukopenia (11), lymphopenia (7), thrombocytopenia (5). Best response for 22 evaluable patients was PD (8), SD for at least six cycles (12), PR (1: carcinoma of ovary, dose level 2) and one not assessable. Pharmacokinetic analysis confirmed the prolonged half-life of UCN-01 of approximately 15 days. DLT was observed at DL 3 and RPTD was determined to be DL 2. To date, this combination has been relatively well tolerated with some preliminary evidence of efficacy. A phase II study of this combination in patients with ovarian cancer is underway. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Hotte, S J AU - Oza, A AU - Winquist, E W AU - Moore, M AU - Chen, E X AU - Brown, S AU - Pond, G R AU - Dancey, J E AU - Hirte, H W AD - Princess Margaret Hospital Phase II Consortium, Cancer Therapy Evaluation Program, and National Cancer Institute, Bethesda, MD, USA. sebastien.hotte@hrcc.on.ca Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 334 EP - 340 VL - 17 IS - 2 SN - 0923-7534, 0923-7534 KW - Antineoplastic Agents KW - 0 KW - 7-hydroxystaurosporine KW - 7BU5H4V94A KW - Topotecan KW - 7M7YKX2N15 KW - Staurosporine KW - H88EPA0A3N KW - Index Medicus KW - Antineoplastic Agents -- administration & dosage KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Antineoplastic Agents -- pharmacokinetics KW - Humans KW - Neutropenia -- etiology KW - Aged KW - Staurosporine -- analogs & derivatives KW - Leukopenia -- etiology KW - Staurosporine -- pharmacokinetics KW - Staurosporine -- administration & dosage KW - Salivary Gland Neoplasms -- drug therapy KW - Adult KW - Topotecan -- administration & dosage KW - Middle Aged KW - Female KW - Male KW - Survival Analysis KW - Colonic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70694778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Phase+I+trial+of+UCN-01+in+combination+with+topotecan+in+patients+with+advanced+solid+cancers%3A+a+Princess+Margaret+Hospital+Phase+II+Consortium+study.&rft.au=Hotte%2C+S+J%3BOza%2C+A%3BWinquist%2C+E+W%3BMoore%2C+M%3BChen%2C+E+X%3BBrown%2C+S%3BPond%2C+G+R%3BDancey%2C+J+E%3BHirte%2C+H+W&rft.aulast=Hotte&rft.aufirst=S&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alterations in skin and stratified epithelia by constitutively activated PPARalpha. AN - 70693875; 16374467 AB - Peroxisome proliferator-activated receptor (PPAR)alpha is a pleiotropic regulator in many cell types and has recently been implicated in skin homeostasis. To determine the role of PPARalpha in skin physiology, transgenic mice were generated using the tetracycline Tet-off regulatory system to target constitutively activated PPARalpha to the epidermis and other stratified epithelia by the bovine keratin K5 promoter. Expression of the transgene during early development resulted in postnatal lethality within 2 days after birth. A thin epidermis, few hair follicles, and abnormal development of the tongue were observed in neonatal transgenic mice. Early mortality was not observed when transgenic PPARalpha expression was diminished by administration of doxycycline (dox) to the mothers. The alterations noted in neonatal mice were not observed in adult mice upon re-expression of the PPARalpha transgene by withdrawing dox. Attenuated hyperplasia of interfollicular epidermis after topical application of the tumor promotor 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was observed in adult mice expressing the PPARalpha transgene. In addition, expression of the PPARalpha transgene in mammary gland during pregnancy resulted in abnormal development of this organ and impaired lactation. Further investigations using primary keratinocytes revealed that expression of the transgene in keratinocytes resulted in increased differentiation and decreased proliferation, which may contribute to the observed phenotype in the transgenic mice. Thus, these results indicate that PPARalpha plays an important role in the development of stratified epithelia including skin, tongue, and mammary gland. JF - The Journal of investigative dermatology AU - Yang, Qian AU - Yamada, Atsushi AU - Kimura, Shioko AU - Peters, Jeffrey M AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 374 EP - 385 VL - 126 IS - 2 SN - 0022-202X, 0022-202X KW - PPAR alpha KW - 0 KW - Phorbol Esters KW - Doxycycline KW - N12000U13O KW - Index Medicus KW - Animals KW - Doxycycline -- pharmacology KW - Cell Differentiation KW - Mice KW - Cell Proliferation KW - Mice, Transgenic KW - Pregnancy KW - Phorbol Esters -- pharmacology KW - Epithelium -- growth & development KW - Lactation -- genetics KW - Keratinocytes -- cytology KW - Keratinocytes -- metabolism KW - Epithelium -- embryology KW - Female KW - Skin -- drug effects KW - Mammary Glands, Animal -- physiology KW - Skin -- growth & development KW - Skin -- cytology KW - Mammary Glands, Animal -- growth & development KW - PPAR alpha -- physiology KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70693875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Alterations+in+skin+and+stratified+epithelia+by+constitutively+activated+PPARalpha.&rft.au=Yang%2C+Qian%3BYamada%2C+Atsushi%3BKimura%2C+Shioko%3BPeters%2C+Jeffrey+M%3BGonzalez%2C+Frank+J&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2006-02-01&rft.volume=126&rft.issue=2&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Invest Dermatol. 2006 Feb;126(2):241-2 [16418732] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice. AN - 70688469; 16415020 AB - Langat virus (LGT), the naturally attenuated member of the tick-borne encephalitis virus (TBEV) complex, was tested extensively in clinical trials as a live TBEV vaccine and was found to induce a protective, durable immune response; however, it retained a low residual neuroinvasiveness in mice and humans. In order to ablate or reduce this property, LGT mutants that produced a small plaque size or temperature-sensitive (ts) phenotype in Vero cells were generated using 5-fluorouracil. One of these ts mutants, clone E5-104, exhibited a more than 10(3)-fold reduction in replication at the permissive temperature in both mouse and human neuroblastoma cells and lacked detectable neuroinvasiveness for highly sensitive immunodeficient mice. The E5-104 mutant possessed five amino acid substitutions in the structural protein E and one change in each of the nonstructural proteins NS3 and NS5. Using reverse genetics, we demonstrated that a Lys(46)-->Glu substitution in NS3 as well as a single Lys(315)-->Glu change in E significantly impaired the growth of LGT in neuroblastoma cells and reduced its peripheral neurovirulence for SCID mice. This study and our previous experience with chimeric flaviviruses indicated that a decrease in viral replication in neuroblastoma cells might serve as a predictor of in vivo attenuation of the neurotropic flaviviruses. The combination of seven mutations identified in the nonneuroinvasive E5-104 mutant provided a useful foundation for further development of a live attenuated TBEV vaccine. An evaluation of the complete sequence of virus recovered from brain of SCID mice inoculated with LGT mutants identified sites in the LGT genome that promoted neurovirulence/neuroinvasiveness. JF - Journal of virology AU - Rumyantsev, Alexander A AU - Murphy, Brian R AU - Pletnev, Alexander G AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases/NIH, 12735 Twinbrook Parkway, Twinbrook 3, Room 3W13, MSC 8133, Bethesda, MD 20892-8133, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 1427 EP - 1439 VL - 80 IS - 3 SN - 0022-538X, 0022-538X KW - Vaccines, Attenuated KW - 0 KW - Viral Envelope Proteins KW - Viral Vaccines KW - Index Medicus KW - Virus Replication KW - Animals KW - Models, Molecular KW - Humans KW - Viral Vaccines -- genetics KW - Temperature KW - Neuroblastoma -- virology KW - Brain -- virology KW - Cell Line, Tumor KW - Mice KW - Mutagenesis KW - Phenotype KW - Viral Envelope Proteins -- immunology KW - Viral Envelope Proteins -- chemistry KW - Virulence -- genetics KW - Cercopithecus aethiops KW - Vaccines, Attenuated -- genetics KW - Encephalitis, Tick-Borne -- immunology KW - Vero Cells KW - Mice, SCID KW - Encephalitis, Tick-Borne -- virology KW - Mutation KW - Viral Envelope Proteins -- genetics KW - Protein Conformation KW - Encephalitis Viruses, Tick-Borne -- pathogenicity KW - Encephalitis Viruses, Tick-Borne -- genetics KW - Encephalitis Viruses, Tick-Borne -- physiology KW - Encephalitis Viruses, Tick-Borne -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70688469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=A+tick-borne+Langat+virus+mutant+that+is+temperature+sensitive+and+host+range+restricted+in+neuroblastoma+cells+and+lacks+neuroinvasiveness+for+immunodeficient+mice.&rft.au=Rumyantsev%2C+Alexander+A%3BMurphy%2C+Brian+R%3BPletnev%2C+Alexander+G&rft.aulast=Rumyantsev&rft.aufirst=Alexander&rft.date=2006-02-01&rft.volume=80&rft.issue=3&rft.spage=1427&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2001 Oct;75(20):9731-40 [11559806] Virology. 2001 Apr 10;282(2):288-300 [11289811] J Virol. 2002 Jan;76(2):525-31 [11752143] Virology. 2000 Mar 30;269(1):225-37 [10725214] Virology. 2000 Aug 15;274(1):26-31 [10936085] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3036-41 [11880643] EMBO J. 2002 Jun 3;21(11):2757-68 [12032088] J Virol. 2003 Jan;77(2):1653-7 [12502885] Antiviral Res. 2003 Jan;57(1-2):129-46 [12615309] Adv Virus Res. 2003;60:1-42 [14689690] Adv Virus Res. 2003;59:23-61 [14696326] J Virol. 2004 Nov;78(22):12497-507 [15507637] Am J Epidemiol. 1966 Sep;84(2):193-213 [4958356] Am J Epidemiol. 1966 Sep;84(2):225-33 [5920389] Jpn J Med Sci Biol. 1967 Dec;20 Suppl:130-2 [4872428] Am J Epidemiol. 1968 Jul;88(1):103-11 [4969351] Bull World Health Organ. 1970;42(1):89-94 [5309521] Am J Trop Med Hyg. 1973 Jan;22(1):100-8 [4630881] J Infect Dis. 1977 Aug;136(2):256-62 [894078] Infect Immun. 1980 Jan;27(1):175-80 [6766902] Indian J Med Res. 1981 Feb;73:141-9 [6263797] J Hyg Epidemiol Microbiol Immunol. 1981;25(2):155-62 [6265549] J Virol. 1989 May;63(5):2357-60 [2539524] Nucleic Acids Res. 1989 May 25;17(10):3889-97 [2543956] J Virol. 1989 Sep;63(9):4034-8 [2548013] Virology. 1989 Aug;171(2):637-9 [2548336] Tr Inst Im Pastera. 1989;65:133-5 [2629181] Virology. 1991 Dec;185(2):891-5 [1720591] J Gen Virol. 1993 Apr;74 ( Pt 4):733-40 [8385698] Nature. 1995 May 25;375(6529):291-8 [7753193] Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1746-51 [9465088] J Virol. 1999 Feb;73(2):871-7 [9882287] J Virol. 1999 Feb;73(2):1374-81 [9882342] J Gen Virol. 1999 Jan;80 ( Pt 1):179-85 [9934700] J Biol Chem. 1999 Feb 26;274(9):5573-80 [10026173] BMC Infect Dis. 2004 Oct 4;4:39 [15461822] J Gen Virol. 2005 May;86(Pt 5):1403-13 [15831952] Virus Res. 2005 Aug;111(2):161-74 [15871909] Vaccine. 2006 Jan 12;24(2):133-43 [16115704] J Virol. 2001 Jan;75(2):934-42 [11134306] Virology. 2001 Oct 10;289(1):129-36 [11601924] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice. AN - 70685164; 16034441 AB - Repeated exposure to drugs of abuse results in an increased sensitivity to their behavioral effects, a phenomena referred to as behavioral sensitization. It has been suggested that the same neuroadaptations underlying behavioral sensitization contribute to the maintenance and reinstatement of addiction. Dysregulation of dopamine (DA) neurotransmission in the mesoaccumbens system is one neuroadaptation that is thought to lead to the compulsive drug-seeking that characterizes addiction. Evidence that sensitization to psychostimulants and opiates is associated with an enhancement of drug-evoked DA levels in the nucleus accumbens has also been obtained. Like other drugs of abuse, the acute administration of ethanol (ETOH) stimulates DA release in this brain region. Moreover, repeated ETOH experience results in an enhanced behavioral response to a subsequent ethanol challenge. Data regarding the influence of repeated ethanol intoxication and withdrawal upon mesoaccumbal DA neurotransmission is limited. Studies examining ETOH-evoked alterations in mesoaccumbal DA neurotransmission as a function of withdrawal duration are lacking. The present experiments quantified basal and ethanol-evoked DA levels 14 days and 24 h following the cessation of a repeated ETOH intoxication protocol, which results in sensitization to the locomotor activating effects of ethanol. Locomotor activity was assessed in parallel groups of animals. Studies were conducted in two mouse strains, C57BL/6J and DBA/2J, which differ in their behavioral responses to ETOH. The results indicate the development of transient tolerance to both ETOH-induced behavioral activation and evoked accumbens DA release at early withdrawal. Moreover, no enhanced DA response to a subsequent ETOH challenge could be demonstrated in ETOH experienced animals 2 weeks after withdrawal, in spite of the observation of clear behavioral sensitization at this time point. These results suggest that, at least in the case of ethanol, sensitization of the DA mesolimbic system may not be necessary for the development of behavioral sensitization. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Zapata, Agustin AU - Gonzales, Rueben A AU - Shippenberg, Toni S AD - Integrative Neuroscience Section, Behavioral Neuroscience Branch National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA. Azapata@intra.nida.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 396 EP - 405 VL - 31 IS - 2 SN - 0893-133X, 0893-133X KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Severity of Illness Index KW - Behavior, Animal -- drug effects KW - Animals KW - Drug Administration Schedule KW - Mice, Inbred C57BL KW - Mice KW - Time Factors KW - Microdialysis -- methods KW - Male KW - Mice, Inbred DBA KW - Ethanol -- blood KW - Alcoholic Intoxication -- physiopathology KW - Alcoholic Intoxication -- etiology KW - Nucleus Accumbens -- drug effects KW - Central Nervous System Depressants -- blood KW - Ethanol -- administration & dosage KW - Dopamine -- metabolism KW - Motor Activity -- drug effects KW - Central Nervous System Depressants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70685164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Repeated+ethanol+intoxication+induces+behavioral+sensitization+in+the+absence+of+a+sensitized+accumbens+dopamine+response+in+C57BL%2F6J+and+DBA%2F2J+mice.&rft.au=Zapata%2C+Agustin%3BGonzales%2C+Rueben+A%3BShippenberg%2C+Toni+S&rft.aulast=Zapata&rft.aufirst=Agustin&rft.date=2006-02-01&rft.volume=31&rft.issue=2&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-06 N1 - Date created - 2006-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 2005 Mar;29(3):326-33 [15770106] Alcohol Alcohol. 1999 May-Jun;34(3):283-8 [10414602] Eur J Pharmacol. 2000 Jan 24;388(1):69-76 [10657548] J Pharmacol Exp Ther. 2000 Apr;293(1):121-7 [10734161] Alcohol Clin Exp Res. 2000 Jul;24(7):1120-4 [10924018] Psychopharmacology (Berl). 2000 Aug;151(2-3):99-120 [10972458] Addiction. 2001 Jan;96(1):103-14 [11177523] Psychopharmacology (Berl). 2001 Apr;155(1):91-9 [11374341] Neuropharmacology. 2001 Sep;41(3):351-9 [11522326] Pharmacol Biochem Behav. 2001 Apr;68(4):685-90 [11526965] J Neurochem. 2001 Nov;79(3):626-35 [11701766] Pharmacol Biochem Behav. 2002 Mar;71(3):509-15 [11830185] Psychopharmacology (Berl). 2002 Feb;160(1):39-48 [11862372] Alcohol Clin Exp Res. 2002 Jul;26(7):1024-30 [12170113] Eur J Neurosci. 2003 Feb;17(3):590-6 [12581176] Psychopharmacology (Berl). 2003 May;167(3):225-34 [12669179] Behav Neurosci. 2003 Jun;117(3):641-9 [12802892] Pharmacol Ther. 2003 Jul;99(1):79-94 [12804700] Nat Neurosci. 2003 Sep;6(9):968-73 [12897785] J Neurosci. 2004 Feb 18;24(7):1594-603 [14973247] Alcohol Clin Exp Res. 2004 Feb;28(2):233-46 [15112931] Eur J Pharmacol. 1976 Nov;40(1):45-56 [1033072] Med Biol. 1977 Apr;55(2):101-8 [865152] Med Biol. 1977 Oct;55(5):284-91 [22792] J Pharmacol Exp Ther. 1978 Jul;206(1):75-80 [660560] J Neural Transm. 1981;50(1):57-67 [6110703] Neurobehav Toxicol Teratol. 1983 Mar-Apr;5(2):181-7 [6683363] J Pharmacol Exp Ther. 1986 Oct;239(1):219-28 [3761194] Alcohol. 1992 Jan-Feb;9(1):17-22 [1370758] Psychopharmacology (Berl). 1992;107(2-3):385-93 [1352057] Psychopharmacology (Berl). 1992;107(2-3):453-6 [1615143] Alcohol Clin Exp Res. 1992 Jun;16(3):529-32 [1626652] J Neurosci. 1993 Jan;13(1):266-75 [8423473] J Neurosci. 1993 Jan;13(1):276-84 [8380850] Eur J Pharmacol. 1993 Feb 9;231(2):203-7 [8453975] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7966-9 [8367449] Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 [8401595] Behav Neurosci. 1994 Aug;108(4):789-803 [7986372] Psychopharmacology (Berl). 1994 Sep;116(1):26-32 [7862927] Alcohol Alcohol Suppl. 1993;2:477-82 [7748342] Psychopharmacology (Berl). 1995 Mar;118(1):28-36 [7597119] Psychopharmacology (Berl). 1995 Aug;120(4):475-82 [8539330] J Neurosci. 1996 May 15;16(10):3474-85 [8627380] Psychopharmacology (Berl). 1996 Aug;126(4):301-10 [8878346] Int Rev Neurobiol. 1996;39:243-82 [8894850] Alcohol. 1997 Jul-Aug;14(4):319-26 [9209546] Psychopharmacology (Berl). 1997 Sep;133(1):69-76 [9335083] Brain Res Brain Res Rev. 1997 Oct;25(2):192-216 [9403138] Neuroscience. 1998 Jan;82(2):521-8 [9466458] J Neurosci. 1998 Apr 15;18(8):3023-34 [9526019] Alcohol Clin Exp Res. 1998 Apr;22(2):367-74 [9581642] J Psychopharmacol. 1998;12(1):49-53 [9584968] J Neurochem. 1998 Aug;71(2):684-92 [9681459] Psychopharmacology (Berl). 1998 Jul;138(1):82-8 [9694530] Psychopharmacology (Berl). 1999 Jan;141(3):307-14 [10027512] Neuroscience. 1999 May;90(2):447-55 [10215150] Eur J Pharmacol. 2000 Jan 17;387(3):R23-5 [10650185] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease. AN - 70684327; 16257256 AB - The pancreas is a complex exocrine and endocrine gland that controls many homeostatic functions. The exocrine pancreas produces and secretes digestive enzymes, whereas, the endocrine pancreas produces four distinct hormones, chief among them being the glucose regulating hormone-insulin. Diabetes, pancreatitis and pancreatic cancer are some of the main afflictions that result from pancreas dysfunction. Transforming growth factor-beta (TGF-beta) proteins are central regulators of pancreas cell function, and have key roles in pancreas development and pancreatic disease. Since expression levels and kinase activities of components of TGF-beta signaling are aberrantly altered in diseases of the pancreas, modulating the activity of TGF-beta provides a unique and rational opportunity for therapeutic intervention. Although TGF-beta still remains elusive in terms of our understanding of its multifunctional modes of action, research is moving closer to the design of approaches directed toward modulating its activities for therapeutic benefit. JF - Cytokine & growth factor reviews AU - Rane, Sushil G AU - Lee, Ji-Hyeon AU - Lin, Huei-Min AD - Cell Cycle and Human Diseases Group, Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. sushil_rane@nih.gov PY - 2006 SP - 107 EP - 119 VL - 17 IS - 1-2 SN - 1359-6101, 1359-6101 KW - Transforming Growth Factor beta KW - 0 KW - Index Medicus KW - Animals KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- metabolism KW - Humans KW - Multigene Family -- immunology KW - Pancreatic Neoplasms -- immunology KW - Signal Transduction -- physiology KW - Pancreatic Diseases -- pathology KW - Pancreatic Diseases -- metabolism KW - Transforming Growth Factor beta -- physiology KW - Pancreas -- metabolism KW - Signal Transduction -- genetics KW - Pancreas -- embryology KW - Transforming Growth Factor beta -- genetics KW - Pancreatic Diseases -- immunology KW - Pancreas -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70684327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine+%26+growth+factor+reviews&rft.atitle=Transforming+growth+factor-beta+pathway%3A+role+in+pancreas+development+and+pancreatic+disease.&rft.au=Rane%2C+Sushil+G%3BLee%2C+Ji-Hyeon%3BLin%2C+Huei-Min&rft.aulast=Rane&rft.aufirst=Sushil&rft.date=2006-02-01&rft.volume=17&rft.issue=1-2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Cytokine+%26+growth+factor+reviews&rft.issn=13596101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2006-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interferon alpha2b augments suppressed immune functions in tobacco-related head and neck squamous cell carcinoma patients by modulating cytokine signaling. AN - 70678461; 16249117 AB - We have examined the role of interferon alpha2b (IFNalpha2b) in augmentation of the suppressed immune functions and cytotoxicity of tobacco-related head and neck squamous cell carcinoma (HNSCC) patients. The suppressed killing activity of PBMC of HNSCC patients towards KB, MCF7 and K562 cell lines could be restored by in vitro treatment of PBMC with IFNalpha2b, as detected by LDH release assay. HNSCC patients with cisplatin + 5FU + IFNalpha2b treatment showed greater cytotoxic efficacy than corresponding pretreatment values. Analysis of culture supernatant of HNSCC-PBMC by ELISA revealed the lower secretion of IL-12 and IFNgamma with increased level of IL-4 and IL-10. This altered Th1/Th2 status was rectified after in vitro and in vivo IFNalpha2b stimulation. Increased secretion of monocyte derived IL-12 was observed after IFNalpha2b treatment that can enhance the IFNgamma release, a key regulator for cytotoxicity. IFNalpha2b stimulated enhancement of NK cells may be the source of greater amount of IFNgamma. IFNalpha2b activated STAT1 and STAT4 signaling is observed to be involved in the regulation and maintenance of cytokine milieu. We conclude that IFNalpha2b may be effective as a tool for adjuvant therapy along with conventional therapies to overcome the immunosuppression in HNSCC patients. JF - Oral oncology AU - Bose, Anamika AU - Ghosh, Diptendu AU - Pal, Smarajit AU - Mukherjee, Kalyan K AU - Biswas, Jaydip AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37 S.P. Mookherjee Road, Kolkata, West Bengal 700026, India. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 161 EP - 171 VL - 42 IS - 2 SN - 1368-8375, 1368-8375 KW - Cytokines KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Index Medicus KW - Humans KW - Cytotoxicity, Immunologic -- immunology KW - Immune Tolerance KW - Lymphocyte Count KW - Tumor Cells, Cultured KW - T-Lymphocyte Subsets -- immunology KW - Adult KW - Signal Transduction -- immunology KW - Cell Adhesion -- immunology KW - Middle Aged KW - Female KW - Killer Cells, Natural -- immunology KW - Male KW - Macrophage Activation -- immunology KW - Interferon-alpha -- immunology KW - Carcinoma, Squamous Cell -- immunology KW - Carcinoma, Squamous Cell -- etiology KW - Head and Neck Neoplasms -- etiology KW - Tobacco Use Disorder -- immunology KW - Cytokines -- immunology KW - Tobacco Use Disorder -- complications KW - Head and Neck Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70678461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+oncology&rft.atitle=Interferon+alpha2b+augments+suppressed+immune+functions+in+tobacco-related+head+and+neck+squamous+cell+carcinoma+patients+by+modulating+cytokine+signaling.&rft.au=Bose%2C+Anamika%3BGhosh%2C+Diptendu%3BPal%2C+Smarajit%3BMukherjee%2C+Kalyan+K%3BBiswas%2C+Jaydip%3BBaral%2C+Rathindranath&rft.aulast=Bose&rft.aufirst=Anamika&rft.date=2006-02-01&rft.volume=42&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Oral+oncology&rft.issn=13688375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-25 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent trends in drug abuse in China. AN - 70675669; 16412261 AB - Drug abuse has spread quickly since reemerging as a national problem in China in the late 1980s. The number of registered drug abusers increased from 70,000 in 1990 to more than one million by the end of 2004. In addition to opioids, abuse of 'new' types of drugs including 3,4-methylenedioxymethamphetamine (MDMA) and ketamine has spread since 1997. Illicit drug trafficking and production have swept most of southern China, and throughout the country drug abuse has caused many problems for both abusers and the community. One major drug-related problem is the spread of HIV, which has caused major social and economic damage in China. In response, the Chinese government has begun an anti-drug campaign, including legislative measures to control drug abuse. However, changing the public's attitudes toward drug abusers and breaking the link between drug use and HIV spread are equally important. JF - Acta pharmacologica Sinica AU - Fang, Yu-xia AU - Wang, Yan-bo AU - Shi, Jie AU - Liu, Zhi-min AU - Lu, Lin AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 140 EP - 144 VL - 27 IS - 2 SN - 1671-4083, 1671-4083 KW - Ketamine KW - 690G0D6V8H KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Opioid-Related Disorders -- epidemiology KW - HIV Infections -- complications KW - China -- epidemiology KW - Substance Abuse, Intravenous -- epidemiology KW - Substance Abuse, Intravenous -- complications KW - Substance Abuse, Intravenous -- prevention & control KW - Opioid-Related Disorders -- prevention & control KW - HIV Infections -- epidemiology KW - Drug and Narcotic Control -- legislation & jurisprudence KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70675669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+pharmacologica+Sinica&rft.atitle=Recent+trends+in+drug+abuse+in+China.&rft.au=Fang%2C+Yu-xia%3BWang%2C+Yan-bo%3BShi%2C+Jie%3BLiu%2C+Zhi-min%3BLu%2C+Lin&rft.aulast=Fang&rft.aufirst=Yu-xia&rft.date=2006-02-01&rft.volume=27&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Acta+pharmacologica+Sinica&rft.issn=16714083&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-11 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Higher magnitude accumbal phasic firing changes among core neurons exhibiting tonic firing increases during cocaine self-administration. AN - 70658801; 16325346 AB - Studies using i.v. cocaine self-administration in rats have documented rapid-phasic changes in the firing rate of nucleus accumbens neurons within seconds of cocaine-reinforced lever presses, as well as changes that occur over the course of the cocaine self-administration experiment, i.e. tonic changes in firing rate. During the self-administration period of the experiment, individual neurons exhibit either a tonic increase, a tonic decrease, or no tonic change in firing rate, relative to the neuron's firing rate during the pre-drug period. We evaluated whether rapid-phasic changes in firing were differentially associated with tonically reduced or tonically elevated firing of nucleus accumbens core and shell neurons in cocaine self-administering rats. Rapid-phasic firing patterns within seconds of the cocaine-reinforced lever press were exhibited predominantly by core neurons that also exhibited tonic increases in firing. Conversely, core neurons that did not exhibit such rapid-phasic firing patterns were more likely to show tonically reduced firing. Moreover, core neurons were more likely than shell neurons to exhibit: 1) tonic increases in firing and 2) rapid-phasic increases in firing preceding the cocaine-reinforced lever press. These differences between accumbens subterritories may be related to their distinct involvement in operant responding; the present findings are consistent with an emerging literature which implicates shell in contextual stimulus-induced responding, and core in processing the instrumental response via its discrete output to classic basal ganglia structures. The distinct tendency of the core to exhibit increased firing, coupled with its dichotomous firing outputs (i.e. tonic decreases without rapid phasic responses or tonic increases with rapid phasic responses), may reflect particular sensitivity of these neurons to excitatory limbic afferent signaling involved in instrumental responding. Enhanced phasic responsivity in the core may be an integral component of the mechanism inherent in normal reward processing which is subverted by chronic drug exposure. JF - Neuroscience AU - Ghitza, U E AU - Prokopenko, V F AU - West, M O AU - Fabbricatore, A T AD - Behavioral Neuroscience, Clinical Pharmacology and Therapeutics Research Branches, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 1075 EP - 1085 VL - 137 IS - 3 SN - 0306-4522, 0306-4522 KW - Central Nervous System Stimulants KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Generalization (Psychology) -- drug effects KW - Conditioning, Operant -- drug effects KW - Animals KW - Discrimination (Psychology) -- drug effects KW - Self Administration KW - Reinforcement Schedule KW - Rats, Long-Evans KW - Electrophysiology KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Nucleus Accumbens -- drug effects KW - Neurons -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Nucleus Accumbens -- cytology KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70658801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Higher+magnitude+accumbal+phasic+firing+changes+among+core+neurons+exhibiting+tonic+firing+increases+during+cocaine+self-administration.&rft.au=Ghitza%2C+U+E%3BProkopenko%2C+V+F%3BWest%2C+M+O%3BFabbricatore%2C+A+T&rft.aulast=Ghitza&rft.aufirst=U&rft.date=2006-02-01&rft.volume=137&rft.issue=3&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-12 N1 - Date created - 2006-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol. AN - 70195336; 16094607 AB - Hypermethylation of CpG sites within the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tumors induced by initiation-promotion protocols, methylation of the MGMT promoter was examined in tumor DNA using methylation-specific PCR. To determine whether MGMT promoter methylation was affected by the tumor induction protocol, tumors were initiated by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA) or mezerein. Although the MGMT promoter was not methylated in normal skin, promoter methylation was found in 56 of 136 papillomas (41.2%) and in 19 of 37 squamous cell carcinomas (51.4%). When methylation of the MGMT promoter was compared in the 4 treatment groups, hypermethylation was found more frequently in tumors initiated by DMBA and promoted by mezerein, a protocol associated with a high frequency of malignant conversion. Methylation was found in some tumors as early as 5 weeks after initiation, but the methylation frequency increased with time. MGMT promoter methylation reduced MGMT expression as determined by immunohistochemistry. Although MGMT promoter methylation was not generally correlated with ras mutations, the frequency of MGMT methylation was higher in MNNG-initiated, mezerein-promoted papillomas with mutations in Ha-ras compared to papillomas with Ki-ras. Methylation of the MGMT promoter, associated with reduced MGMT expression, is found in nearly half of mouse skin tumors, but varies with both the tumor initiator and tumor promoter, and may be a key step in the progression from papillomas to carcinomas. Copyright 2005 Wiley-Liss, Inc. JF - International journal of cancer AU - Abdel-Fattah, Rana AU - Glick, Adam AU - Rehman, Ishtiaq AU - Maiberger, Patrick AU - Hennings, Henry AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 527 EP - 531 VL - 118 IS - 3 SN - 0020-7136, 0020-7136 KW - Carcinogens KW - 0 KW - Diterpenes KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - mezerein KW - 34807-41-5 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Genes, ras KW - Gene Expression Regulation, Neoplastic KW - Tetradecanoylphorbol Acetate -- toxicity KW - Diterpenes -- toxicity KW - Animals KW - Skin -- drug effects KW - Methylnitronitrosoguanidine -- toxicity KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Humans KW - Carcinogens -- toxicity KW - Mice KW - Mutation KW - Skin Neoplasms -- genetics KW - DNA Methylation KW - Skin Neoplasms -- chemically induced KW - Carcinoma, Squamous Cell -- genetics KW - Carcinoma, Squamous Cell -- chemically induced KW - Promoter Regions, Genetic -- genetics KW - Papilloma -- genetics KW - O(6)-Methylguanine-DNA Methyltransferase -- genetics KW - Papilloma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70195336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Methylation+of+the+O6-methylguanine-DNA+methyltransferase+promoter+suppresses+expression+in+mouse+skin+tumors+and+varies+with+the+tumor+induction+protocol.&rft.au=Abdel-Fattah%2C+Rana%3BGlick%2C+Adam%3BRehman%2C+Ishtiaq%3BMaiberger%2C+Patrick%3BHennings%2C+Henry&rft.aulast=Abdel-Fattah&rft.aufirst=Rana&rft.date=2006-02-01&rft.volume=118&rft.issue=3&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does radiotherapy dose correlate with incidence of thyroid cancer in survivors of childhood tumors? AN - 68785261; 16932256 JF - Nature clinical practice. Endocrinology & metabolism AU - Tucker, Margaret A AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7236, USA. tuckerp@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 68 EP - 69 VL - 2 IS - 2 SN - 1745-8366, 1745-8366 KW - Index Medicus KW - Risk KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Incidence KW - Survivors KW - Radionuclide Imaging KW - Thyroid Neoplasms -- epidemiology KW - Neoplasms -- radiotherapy KW - Thyroid Neoplasms -- diagnostic imaging KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68785261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Endocrinology+%26+metabolism&rft.atitle=Does+radiotherapy+dose+correlate+with+incidence+of+thyroid+cancer+in+survivors+of+childhood+tumors%3F&rft.au=Tucker%2C+Margaret+A&rft.aulast=Tucker&rft.aufirst=Margaret&rft.date=2006-02-01&rft.volume=2&rft.issue=2&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Endocrinology+%26+metabolism&rft.issn=17458366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-15 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of drug-metabolising enzymes in clinical responses to chemotherapy. AN - 68668226; 16863465 AB - Interindividual differences in efficacy and toxicity of cancer chemotherapy are especially important given the narrow therapeutic index of these drugs. Pharmacokinetic and pharmacodynamic responses to chemotherapy are difficult to predict in a particular patient as numerous variables (e.g., age, gender, concomitant medications and concomitant illness) can alter drug responses. Inherited variations in genes involved in drug metabolism have also been shown to contribute to altered responses to cancer treatment. There are several clinically relevant examples of genetic polymorphisms in drug-metabolising enzymes that alter outcomes of patients treated with chemotherapy agents. It may be possible to predict a patient's response to a particular chemotherapy agent based on knowledge of their genetic composition through in vivo phenotyping of drug-metabolising enzymes. JF - Expert opinion on drug metabolism & toxicology AU - Scripture, Charity D AU - Figg, William D AU - Sparreboom, Alex AD - National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 17 EP - 25 VL - 2 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Phenotype KW - Animals KW - Polymorphism, Genetic -- physiology KW - Humans KW - Treatment Outcome KW - Neoplasms -- drug therapy KW - Neoplasms -- enzymology KW - Cytochrome P-450 Enzyme System -- physiology KW - Antineoplastic Agents -- metabolism KW - Antineoplastic Agents -- therapeutic use KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68668226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=The+role+of+drug-metabolising+enzymes+in+clinical+responses+to+chemotherapy.&rft.au=Scripture%2C+Charity+D%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Scripture&rft.aufirst=Charity&rft.date=2006-02-01&rft.volume=2&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-01 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Role of the monoamine system in the brain on the development of psychological dependence on toluene]. AN - 67870776; 16619847 AB - Abuse of volatile organic solvents among youth remains a major social problem in Japan. Organic solvents are cheap and relatively easy to obtain, so they carry the risk of becoming a so-called "gate-way drug" for users. Psychological dependence assessment systems have been established for drug inhalation using the conditioned place preference (CPP) procedure. We found toluene produced the rewarding effect in this new CPP system. The mesolimbic dopamine pathway, which includes dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and their targets in the limbic forebrain, especially the nucleus accumbens (NAC), is one of the most important substrates for the development of psychological dependence on drugs such as stimulants, cocaine, and heroin. Recently, it has indicated that the VTA-NAC pathway (monoamine system) may play an important role of the expression of psychological dependence on the volatile organic solvent toluene. Clarification of organic solvent's mechanism for the development of psychological dependence focusing on the monoamine system can be exploited for the new medicine and useful treatments for dependence on toluene. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Funada, Masahiko AU - Sato, Mio AU - Aoo, Naoya AU - Wada, Kiyoshi AD - Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8553, Japan. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 31 EP - 38 VL - 41 IS - 1 SN - 1341-8963, 1341-8963 KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - Solvents KW - Serotonin KW - 333DO1RDJY KW - Toluene KW - 3FPU23BG52 KW - Dopamine KW - VTD58H1Z2X KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Norepinephrine -- physiology KW - Animals KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Serotonin -- physiology KW - Nucleus Accumbens KW - Humans KW - Ventral Tegmental Area KW - Substance Abuse Detection -- methods KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- etiology KW - Dopamine -- physiology KW - Solvents -- adverse effects KW - Toluene -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67870776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=%5BRole+of+the+monoamine+system+in+the+brain+on+the+development+of+psychological+dependence+on+toluene%5D.&rft.au=Funada%2C+Masahiko%3BSato%2C+Mio%3BAoo%2C+Naoya%3BWada%2C+Kiyoshi&rft.aulast=Funada&rft.aufirst=Masahiko&rft.date=2006-02-01&rft.volume=41&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Association between substance abuse problems and antisocial tendencies in male juvenile delinquents: A study using the Psychopathy Checklist, Youth Version]. AN - 67870717; 16619849 AB - We examined an association between substance abuse problems and antisocial tendencies in male juvenile delinquents. Subjects were 57 male adolescents consecutively incarcerated between December 2004 and February 2005 in a juvenile classification home. A self-reporting questionnaire was used to assess substance abuse problems in the subjects: Drug abuse problems were assessed by the Drug Abuse Screening Test (DAST-20), and alcohol abuse problems were assessed by the Quantities-Frequencies Scale (QFS). A semi-structured interview was also preformed according to the Psychopathy Checklist, Youth Version (PCL: YV). Associations between questionnaire responses and interview findings were examined using Pearson's correlation or Spearman's rank correlation test. Of our subjects, the 17.5% were recognized as a problematic drug abuser, and the 52.6% as a problematic drinker. Neither of the total DAST-20 nor QFS score was significantly correlated with the total PCL: YV score, and also with each score of the four PCL: YV subfactors. However, significant correlations were found between some items on the PCL: YV and the DAST-20 or QFS score. The DAST score was significant correlated with the PCL: YV item, "impression management" (rs=0.35, p<0.001), and the QFS score was significant correlated with "serious violations of conditional release" (rs=0.33, p<0.05) and "criminal versatility" (rs=0.48, p<0.001). More than a half of male juvenile delinquents had alcohol abuse problems. Alcohol intake may be considered to promote repetition and diversification of their antisocial behaviors, although overall antisocial tendencies were not associated with drug and alcohol abuse problems in male juvenile delinquents. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Matsumoto, Toshihiko AU - Okada, Takayuki AU - Chiba, Yasuhiko AU - Ando, Kumiko AU - Yoshikawa, Kazuo AU - Wada, Kiyoshi AD - Department of Forensic Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 59 EP - 71 VL - 41 IS - 1 SN - 1341-8963, 1341-8963 KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Adolescent KW - Male KW - Substance-Related Disorders -- diagnosis KW - Antisocial Personality Disorder -- epidemiology KW - Forensic Psychiatry -- methods KW - Interview, Psychological -- methods KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- psychology KW - Substance-Related Disorders -- psychology KW - Substance Abuse Detection -- methods KW - Juvenile Delinquency -- psychology KW - Substance-Related Disorders -- epidemiology KW - Psychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67870717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=%5BAssociation+between+substance+abuse+problems+and+antisocial+tendencies+in+male+juvenile+delinquents%3A+A+study+using+the+Psychopathy+Checklist%2C+Youth+Version%5D.&rft.au=Matsumoto%2C+Toshihiko%3BOkada%2C+Takayuki%3BChiba%2C+Yasuhiko%3BAndo%2C+Kumiko%3BYoshikawa%2C+Kazuo%3BWada%2C+Kiyoshi&rft.aulast=Matsumoto&rft.aufirst=Toshihiko&rft.date=2006-02-01&rft.volume=41&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - External dose estimates for Dolon village: application of the U.S./Russian joint methodology. AN - 67809573; 16571929 AB - Methods to estimate external dose from radioactive fallout from nuclear tests have for many years depended on two types of data: measurements of exposure rate in air and an empirically derived power function to describe the change in exposure rate with time, Over the last four years, a working group with American and Russian participation has developed a bi-national joint methodology that offers an improved capability for estimating external dose. In this method, external dose is estimated using exposure rate functions derived from data from American nuclear tests similar in construction to SNTS (Semipalatinsk Nuclear Test Site) devices. For example, in this paper, we derive doses for test #1 (August 29, 1949) at the SNTS using an exposure rate function for the U.S. TRINITY test. For the case of test #1, the average external dose for a person in Dolon is estimated to have been about 0.5 Gy compared to 1 to 2 Gy estimated in other work. This prediction agrees better with reported EPR measurements in teeth from village residents and with measurements of TL signals in bricks from Dolon buildings. This report presents the basic elements of the joint methodology model for estimation of external dose received from SNTS fallout. JF - Journal of radiation research AU - Simon, Steven L AU - Beck, Harold L AU - Gordeev, Konstantin AU - Bouville, André AU - Anspaugh, Lynn R AU - Land, Charles E AU - Luckyanov, Nicholas AU - Shinkarev, Sergey AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ssimon@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - A143 EP - A147 VL - 47 Suppl A SN - 0449-3060, 0449-3060 KW - Radioactive Fallout KW - 0 KW - Radioisotopes KW - Index Medicus KW - United States KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Computer Simulation KW - International Cooperation KW - Risk Factors KW - Humans KW - Body Burden KW - Environmental Exposure -- analysis KW - Kazakhstan KW - Russia KW - Research KW - Radiation Monitoring -- methods KW - Whole-Body Counting -- methods KW - Radioisotopes -- analysis KW - Risk Assessment -- methods KW - Radioactive Fallout -- analysis KW - Models, Biological KW - Nuclear Warfare -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67809573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+radiation+research&rft.atitle=External+dose+estimates+for+Dolon+village%3A+application+of+the+U.S.%2FRussian+joint+methodology.&rft.au=Simon%2C+Steven+L%3BBeck%2C+Harold+L%3BGordeev%2C+Konstantin%3BBouville%2C+Andr%C3%A9%3BAnspaugh%2C+Lynn+R%3BLand%2C+Charles+E%3BLuckyanov%2C+Nicholas%3BShinkarev%2C+Sergey&rft.aulast=Simon&rft.aufirst=Steven&rft.date=2006-02-01&rft.volume=47+Suppl+A&rft.issue=&rft.spage=A143&rft.isbn=&rft.btitle=&rft.title=Journal+of+radiation+research&rft.issn=04493060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 67804562; 16566620 AB - To present nationally representative data on the lifetime prevalence and comorbidity of 8 specific drug use disorders, separately for abuse and dependence, and mood and anxiety disorders. Data come from a representative sample (N=43,093) of the United States civilian, noninstitutional population 18 years and older. Diagnoses of mood, anxiety, and drug use disorders were based upon face-to-face personal interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). Associations between specific mood and anxiety disorders and specific drug use disorders were virtually all positive and statistically significant (p<.05). In general, associations were greater for dependence than abuse, greater for mood than anxiety disorders, and in some instances stronger among women than men (p<.05). Large odds ratios also were observed for individuals with comorbid mood and anxiety disorders. The comorbidity between specific mood and anxiety disorders and specific drug use disorders is pervasive in the U.S. population. Findings suggest that comorbid psychiatric disorders may increase the risk of greater involvement in more serious illicit drug use disorders and that the greater comorbidity between mood and anxiety and drug use disorders among women may reflect greater deviance and psychopathology among drug-using women than men. Findings also suggest that drug abuse prevention and intervention efforts should address other psychiatric conditions. Further, definitions of drug use disorder phenotypes should give careful consideration to other psychiatric conditions as meaningful characteristics of case heterogeneity. JF - The Journal of clinical psychiatry AU - Conway, Kevin P AU - Compton, Wilson AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 247 EP - 257 VL - 67 IS - 2 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Regression Analysis KW - Sex Factors KW - Alcoholism -- diagnosis KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Comorbidity KW - Depressive Disorder -- epidemiology KW - Psychiatric Status Rating Scales KW - Alcoholism -- epidemiology KW - Adult KW - Health Surveys KW - Depressive Disorder -- diagnosis KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Mood Disorders -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67804562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Lifetime+comorbidity+of+DSM-IV+mood+and+anxiety+disorders+and+specific+drug+use+disorders%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Conway%2C+Kevin+P%3BCompton%2C+Wilson%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2006-02-01&rft.volume=67&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Ment Health. 2006 Nov;9(4):113 [17065310] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blindness of clinical evaluators, parents, and children in a placebo-controlled trial of fluvoxamine. AN - 67781281; 16553542 AB - Few of the increasing number of pediatric clinical trials of selective serotonin reuptake inhibitors (SSRIs) in children have been evaluated for level of blindness of investigators, children, and parents. The success of the masking procedures used in a double-blind, pediatric trial of fluvoxamine in children was examined. Clinical evaluators, parents, and children were asked to guess individual treatment assignment at the end of an 8-week, placebo-controlled trial of fluvoxamine conducted in 128 outpatients (6-17 years of age) with anxiety disorders. The relationship between treatment attribution and improvement status or presence of adverse events was examined. The rate of correct guesses was significantly greater than chance among clinical evaluators (78%), parents (81%), and children (67%) (for all, p < 0.001). Attribution to fluvoxamine was associated with presence of clinical improvement, and attribution to placebo with lack of improvement (p < 0.001) in both the fluvoxamine and placebo group. There was no association between presence of adverse events and direction of the guess. Accuracy of the guess did not improve with time. The tendency to attribute improvement to active treatment and lack of improvement to placebo was consistent across investigators, parents, and children and was applied regardless of actual treatment received by the patient. Adverse events did not influence treatment attribution. JF - Journal of child and adolescent psychopharmacology AU - Vitiello, Benedetto AU - Davis, Mark AU - Greenhill, Laurence L AU - Pine, Daniel S AD - National Institute of Mental Health, Bethesda, Maryland 20892, USA. bvitiell@mail.nih.gov PY - 2006 SP - 219 EP - 225 VL - 16 IS - 1-2 SN - 1044-5463, 1044-5463 KW - Fluvoxamine KW - O4L1XPO44W KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Fluvoxamine -- adverse effects KW - Fluvoxamine -- therapeutic use KW - Physicians KW - Parents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67781281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Blindness+of+clinical+evaluators%2C+parents%2C+and+children+in+a+placebo-controlled+trial+of+fluvoxamine.&rft.au=Vitiello%2C+Benedetto%3BDavis%2C+Mark%3BGreenhill%2C+Laurence+L%3BPine%2C+Daniel+S&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2006-02-01&rft.volume=16&rft.issue=1-2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Science fiction becomes enlightening reality: diagnostic scans. AN - 67727600; 16524356 AB - One of the 20th century's greatest achievements was the development of several imaging methods. These methods facilitate diagnoses and sometimes eliminate the need for surgical exploration. Generally, clinicians and patients consider their benefit worth the minimal risk they pose. Currently, imaging is the fastest growing area of health expense. Each imaging method alone or with contrast media has a unique niche. X-rays, or plain radiographs, can show fracture or simple organ blockage. Computed tomography provides a three-dimensional view with clearer, sharper contrast between the body's structures and tissues. Magnetic resonance imaging can depict musculoskeletal aberrations, tumors, infection, or tissue pathology. Positron-emission tomography quantifies metabolic activity. Consultant pharmacists should be able to differentiate among these scans and understand the benefits and uses of each. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeannette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 116 EP - 8, 125-30, 137 VL - 21 IS - 2 SN - 0888-5109, 0888-5109 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Diagnostic Imaging KW - Magnetic Resonance Imaging KW - Positron-Emission Tomography KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67727600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Science+fiction+becomes+enlightening+reality%3A+diagnostic+scans.&rft.au=Wick%2C+Jeannette+Y&rft.aulast=Wick&rft.aufirst=Jeannette&rft.date=2006-02-01&rft.volume=21&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-07 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ten (or more) good reports to run. AN - 67725996; 16524359 JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeannette Y AU - Zanni, Guido R AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 162 EP - 165 VL - 21 IS - 2 SN - 0888-5109, 0888-5109 KW - Drug Combinations KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - Pharmaceutical Preparations -- administration & dosage KW - Drug Interactions KW - Consultants KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Treatment Outcome KW - Records as Topic KW - Long-Term Care KW - Nursing Homes KW - Drug Therapy KW - Drug Information Services KW - Pharmacists KW - Information Storage and Retrieval UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67725996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Ten+%28or+more%29+good+reports+to+run.&rft.au=Wick%2C+Jeannette+Y%3BZanni%2C+Guido+R&rft.aulast=Wick&rft.aufirst=Jeannette&rft.date=2006-02-01&rft.volume=21&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-07 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. AN - 67682473; 16492920 AB - Nucleotide excision repair enzymes remove bulky damage caused by environmental agents, including carcinogenic polycyclic aromatic hydrocarbons found in cigarette smoke, a risk factor for colorectal adenoma. Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we studied the risk of advanced colorectal adenoma in relation to cigarette smoking and selected single nucleotide polymorphisms (SNP) in the nucleotide excision repair pathway. Cases (n = 772) were subjects with left-sided advanced adenoma (>1 cm in size, high-grade dysplasia, or villous characteristics). Controls (n = 777) were screen-negative for left-sided polyps by sigmoidoscopy. DNA was extracted from blood samples and 15 common nonsynonymous SNPs in seven-nucleotide excision repair genes [XPC, RAD23B (hHR23B), CSB (ERCC6), XPD (ERCC2), CCNH, XPF (ERCC4), and XPG (ERCC5)] were genotyped. None of the studied SNPs were independently associated with advanced adenoma risk. Smoking was related to adenoma risk and XPC polymorphisms (R492H, A499V, K939Q) modified these effects (P(interaction) from 0.03-0.003). Although the three XPC variants were in linkage disequilibrium, a multivariate logistic regression tended to show independent protective effects for XPC 499V (P(trend) = 0.06), a finding supported by haplotype analysis (covariate-adjusted global permutation P = 0.03). Examining a spectrum of polymorphic variants in nucleotide excision repair genes, we found evidence that smoking-associated risks for advanced colorectal adenoma are modified by polymorphisms in XPC, particularly haplotypes containing XPC 499V. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Huang, Wen-Yi AU - Berndt, Sonja I AU - Kang, Daehee AU - Chatterjee, Nilanjan AU - Chanock, Stephen J AU - Yeager, Meredith AU - Welch, Robert AU - Bresalier, Robert S AU - Weissfeld, Joel L AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA. huangw@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 306 EP - 311 VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - DNA-Binding Proteins KW - 0 KW - XPC protein, human KW - 156533-34-5 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Humans KW - Aged KW - Linkage Disequilibrium KW - Multivariate Analysis KW - Genotype KW - Alleles KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - DNA Helicases -- genetics KW - Middle Aged KW - Female KW - Male KW - DNA Repair -- genetics KW - Polymorphism, Single Nucleotide KW - DNA-Binding Proteins -- genetics KW - Smoking -- adverse effects KW - Colorectal Neoplasms -- genetics KW - Smoking -- genetics KW - Adenoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67682473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Nucleotide+excision+repair+gene+polymorphisms+and+risk+of+advanced+colorectal+adenoma%3A+XPC+polymorphisms+modify+smoking-related+risk.&rft.au=Huang%2C+Wen-Yi%3BBerndt%2C+Sonja+I%3BKang%2C+Daehee%3BChatterjee%2C+Nilanjan%3BChanock%2C+Stephen+J%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BBresalier%2C+Robert+S%3BWeissfeld%2C+Joel+L%3BHayes%2C+Richard+B&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residential insecticide use and risk of non-Hodgkin's lymphoma. AN - 67682432; 16492912 AB - Previous studies have linked non-Hodgkin's lymphoma (NHL) with occupational exposure to insecticides, but residential use is largely unexplored. In this population-based case-control study, we examined NHL risk and use of insecticides in the home and garden. We identified NHL cases, uninfected with HIV, diagnosed between 1998 and 2000 among women and men ages 20 to 74 years in Iowa and the metropolitan areas of Los Angeles, Detroit, and Seattle. Controls were selected using random digit dialing or Medicare files. Computer-assisted personal interviews (1,321 cases and 1,057 controls) elicited data on insecticide use at each home occupied since 1970. Insecticide levels were measured in dust taken from used vacuum cleaner bags (682 cases and 513 controls). We previously reported a positive association with dichlorodiphenyldichloroethylene levels in carpet dust residues. Here, we focus on insecticides that were commonly used after 1970, the time period covered by our questionnaire. People whose homes were treated for termites had elevated NHL risk (odds ratio, 1.3; 95% confidence interval, 1.0-1.6). Risk was modestly, although not significantly, elevated in all but one study center and in all sexes and races. The elevation in risk was restricted to people whose homes were treated before the 1988 chlordane ban. There was a significant trend of increasing risk with increasing levels of alpha-chlordane residues in dust (P(trend) = 0.04) and a marginally significant trend for gamma-chlordane (P(trend) = 0.06). We found no evidence of associations for insects overall, for specific types of insects other than termites, or for elevated residues of other insecticides. We concluded that chlordane treatment of homes for termites may increase residents' NHL risk. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Colt, Joanne S AU - Davis, Scott AU - Severson, Richard K AU - Lynch, Charles F AU - Cozen, Wendy AU - Camann, David AU - Engels, Eric A AU - Blair, Aaron AU - Hartge, Patricia AD - Occupational and Environmental Epidemiology Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20852, USA. coltj@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 251 EP - 257 VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - Dust KW - 0 KW - Environmental Pollutants KW - Insecticides KW - Chlordan KW - 12789-03-6 KW - Index Medicus KW - Animals KW - Dust -- analysis KW - Humans KW - Aged KW - Risk Assessment KW - Floors and Floorcoverings KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - Female KW - Male KW - Isoptera KW - Insecticides -- toxicity KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Chlordan -- toxicity KW - Environmental Pollutants -- toxicity KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67682432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Residential+insecticide+use+and+risk+of+non-Hodgkin%27s+lymphoma.&rft.au=Colt%2C+Joanne+S%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BLynch%2C+Charles+F%3BCozen%2C+Wendy%3BCamann%2C+David%3BEngels%2C+Eric+A%3BBlair%2C+Aaron%3BHartge%2C+Patricia&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. AN - 67679147; 16492928 AB - Impaired base-excision repair (BER) function can give rise to the accumulation of DNA damage and initiation of cancer. We evaluated whether genetic variation in six BER pathway genes (XRCC1, ADPRT, APEX1, OGG1, LIG3, and MUTYH) is associated with breast cancer risk in two large population-based case-control studies in the United States (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls). A detailed evaluation was first done in a subset of 1,898 cases and 1,514 controls with mouthwash DNA samples in the U.S. study. Significant findings were followed up in the remainder of the U.S. study population that provided cytobrush DNA samples and in the Polish study. Using data from U.S. study participants with mouthwash DNA, we found no significant overall association between breast cancer risk and XRCC1 R280H and R194W, ADPRT V726W, APEX1 D148E, OGG1 S326C, LIG3 R780H, or MUTYH 5' untranslated region. These data suggested a decreased risk for XRCC1Q399R homozygous variants compared with homozygous wild-type in premenopausal women, but these findings were not confirmed when data from cytobrush DNA samples were added [combined odds ratio (OR), 0.8; 95% confidence interval (95% CI), 0.6-1.1] or in the Polish study (OR, 1.0; 95% CI, 0.7-1.5). Meta-analyses based on our data and published data from studies of two single nucleotide polymorphisms in XRCC1 showed no evidence of an overall association between breast cancer risk and homozygous variants versus wild-type for Q399R (OR, 1.1; 95% CI, 1.0-1.2) or R194W (OR, 1.0; 95% CI, 0.7-1.8), although there was a suggestion for an association in Asian populations for Q399R (OR, 1.6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Zhang, Yawei AU - Newcomb, Polly A AU - Egan, Kathleen M AU - Titus-Ernstoff, Linda AU - Chanock, Stephen AU - Welch, Robert AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Bardin-Mikolajczak, Alicja AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA. yawei.zhang@yale.edu Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 353 EP - 358 VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - DNA-Binding Proteins KW - 0 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - United States KW - DNA Damage KW - Premenopause KW - Humans KW - DNA-Binding Proteins -- genetics KW - Aged KW - Genotype KW - Risk KW - Postmenopause KW - DNA Repair Enzymes -- genetics KW - Poland KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67679147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Genetic+polymorphisms+in+base-excision+repair+pathway+genes+and+risk+of+breast+cancer.&rft.au=Zhang%2C+Yawei%3BNewcomb%2C+Polly+A%3BEgan%2C+Kathleen+M%3BTitus-Ernstoff%2C+Linda%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BBardin-Mikolajczak%2C+Alicja%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BGarcia-Closas%2C+Montserrat&rft.aulast=Zhang&rft.aufirst=Yawei&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent. AN - 67677746; 16490844 AB - To describe the clinical and histologic manifestations of skin reactions incidentally noted in patients with stage IV melanoma who were treated with up to 9 mg/kg of a humanized monoclonal antibody reactive against human cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) as a single agent every 3 weeks. Single-institution prospective study. Patients treated with anti-CTLA-4 as a sole agent were prospectively referred for clinicopathologic characterization of skin reactions occurring during treatment. Specific clinicopathologic features were determined by means of a detailed history, a physical examination, conventional histologic analysis, antibody staining, and complete blood cell counts. Nine (14%) of 63 consecutive patients treated with anti-CTLA-4 as a sole agent developed skin eruptions that were attributed to anti-CTLA-4 in 8 of them. Skin lesions consisted primarily of discrete, pruritic, erythematous, minimally scaly papules that typically coalesced into thin plaques on the trunk and extensor surfaces of the extremities. Extensive alopecia was also noted in 1 patient. Histologically, a superficial, perivascular CD4+-predominant T-cell infiltrate with eosinophils in the dermis, rare dyskeratotic cells, and mild epidermal spongiosis were present. An increase (compared with pretreatment values) in the peripheral blood eosinophil frequency was observed in patients at the time of skin eruptions (P = .006). Specific features of the skin eruption dermatitis with increased tissue and peripheral blood eosinophil levels in a subset of treated patients. Specific features of skin eruption associated with anti-CTLA-4 resemble those described for maculopapular reactions to medications. JF - Archives of dermatology AU - Jaber, Samer H AU - Cowen, Edward W AU - Haworth, Leah R AU - Booher, Susan L AU - Berman, David M AU - Rosenberg, Steven A AU - Hwang, Sam T AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1908, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 166 EP - 172 VL - 142 IS - 2 SN - 0003-987X, 0003-987X KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Neoplasm Staging KW - Humans KW - Skin -- pathology KW - Aged KW - Biopsy KW - Prospective Studies KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Skin Neoplasms -- drug therapy KW - Melanoma -- pathology KW - Drug Eruptions -- immunology KW - Drug Eruptions -- etiology KW - Antigens, Differentiation -- immunology KW - Melanoma -- drug therapy KW - Skin Neoplasms -- pathology KW - Antibodies, Monoclonal -- adverse effects KW - Drug Eruptions -- pathology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67677746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Skin+reactions+in+a+subset+of+patients+with+stage+IV+melanoma+treated+with+anti-cytotoxic+T-lymphocyte+antigen+4+monoclonal+antibody+as+a+single+agent.&rft.au=Jaber%2C+Samer+H%3BCowen%2C+Edward+W%3BHaworth%2C+Leah+R%3BBooher%2C+Susan+L%3BBerman%2C+David+M%3BRosenberg%2C+Steven+A%3BHwang%2C+Sam+T&rft.aulast=Jaber&rft.aufirst=Samer&rft.date=2006-02-01&rft.volume=142&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complementary and alternative medicines patients are talking about: melatonin. AN - 67671052; 16482735 AB - Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced by the pineal gland in the brain in response to darkness. Melatonin is made available when tryptophan is converted to serotonin and then enzymatically converted to melatonin in the pineal gland. Serum levels are low during the day, with peak levels occurring from 2-4 am. JF - Clinical journal of oncology nursing AU - Lee, Colleen O AD - Office of Complementary and Alternative Medicine at the National Cancer Institute, Bethesda, MD, USA. leeco@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 105 EP - 107 VL - 10 IS - 1 SN - 1092-1095, 1092-1095 KW - Adjuvants, Immunologic KW - 0 KW - Antioxidants KW - Melatonin KW - JL5DK93RCL KW - Nursing KW - Travel KW - Patient Education as Topic KW - Drug Interactions KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - Humans KW - Safety KW - Circadian Rhythm -- drug effects KW - Patient Selection KW - Melatonin -- physiology KW - Complementary Therapies -- organization & administration KW - Neoplasms -- drug therapy KW - Adjuvants, Immunologic -- contraindications KW - Antioxidants -- contraindications KW - Melatonin -- contraindications KW - Adjuvants, Immunologic -- physiology KW - Melatonin -- therapeutic use KW - Antioxidants -- therapeutic use KW - Evidence-Based Medicine -- organization & administration KW - Antioxidants -- physiology KW - Adjuvants, Immunologic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67671052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+oncology+nursing&rft.atitle=Complementary+and+alternative+medicines+patients+are+talking+about%3A+melatonin.&rft.au=Lee%2C+Colleen+O&rft.aulast=Lee&rft.aufirst=Colleen&rft.date=2006-02-01&rft.volume=10&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+oncology+nursing&rft.issn=10921095&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-17 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice. AN - 67668160; 16485898 AB - Drug-induced liver disease (DILD) continues to cause significant morbidity and mortality and impair new drug development. Mounting evidence suggests that DILD is a complex, multifactorial disease in which no one factor is likely to be an absolute indicator of susceptibility. As an approach to better understand the multifactorial basis of DILD, we recently compared the hepatic proteomes of mice that were resistant (SJL) and susceptible (C57Bl/6) to APAP-induced liver disease (AILD) wherein we identified potential risk factors and mechanistic pathways responsible for DILD. In this study, we have uncovered additional potential risk factors by comparing hepatic mRNA expression profiles of the same two strains of mice with that of SJLxB6-F1 hybrid (F1) mice, which were found to be of intermediate susceptibility to AILD. Global hepatic gene expression profiling over a 24 h period following APAP treatment revealed elevated patterns in the mRNA expression of cytoprotective genes in resistant SJL mice as compared to susceptible B6 mice, while F1 mice had intermediate mRNA expression levels of these genes. One of these genes encoded for heat shock protein (HSP) 70 whose relative protein expression among the three strains of mice was found to parallel that of their mRNA levels, suggesting that this protein had a protective role against AILD. However, there was no difference in the susceptibility of HSP70 knockout (KO) mice to AILD as compared to wild-type (WT) mice. There were also protoxicant genes, such as osteopontin (OPN), with elevated mRNA expression levels in the B6 mice as compared to the SJL mice and with intermediate levels in the F1 mice, suggesting that they may play a role in exacerbating liver injury after APAP treatment. In support of this hypothesis, OPN KO mice were found to be more resistant to AILD than WT mice. Additionally, the results from both the proteomic and the genomic studies were compared. The two approaches were found to be complementary to each other and not simply overlapping. Our findings suggest that comparative gene expression analysis of susceptible and resistant mouse strains may lead to the identification of factors that could have a role in determining the susceptibility of individuals to DILD. JF - Chemical research in toxicology AU - Welch, Kevin D AU - Reilly, Timothy P AU - Bourdi, Mohammed AU - Hays, Thomas AU - Pise-Masison, Cynthia A AU - Radonovich, Michael F AU - Brady, John N AU - Dix, David J AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. WelchKD@nhlbi.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 223 EP - 233 VL - 19 IS - 2 SN - 0893-228X, 0893-228X KW - HSP70 Heat-Shock Proteins KW - 0 KW - RNA, Messenger KW - Sialoglycoproteins KW - Spp1 protein, mouse KW - Osteopontin KW - 106441-73-0 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Liver -- pathology KW - Sialoglycoproteins -- genetics KW - Liver -- metabolism KW - Mice KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis KW - Mice, Knockout KW - Mice, Inbred Strains KW - Risk Factors KW - Sialoglycoproteins -- biosynthesis KW - Mice, Inbred C57BL KW - Gene Expression Regulation KW - HSP70 Heat-Shock Proteins -- deficiency KW - Time Factors KW - Chemical and Drug Induced Liver Injury KW - Acetaminophen -- chemistry KW - Genetic Predisposition to Disease KW - Liver Diseases -- genetics KW - Acetaminophen -- toxicity KW - Liver Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67668160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Genomic+identification+of+potential+risk+factors+during+acetaminophen-induced+liver+disease+in+susceptible+and+resistant+strains+of+mice.&rft.au=Welch%2C+Kevin+D%3BReilly%2C+Timothy+P%3BBourdi%2C+Mohammed%3BHays%2C+Thomas%3BPise-Masison%2C+Cynthia+A%3BRadonovich%2C+Michael+F%3BBrady%2C+John+N%3BDix%2C+David+J%3BPohl%2C+Lance+R&rft.aulast=Welch&rft.aufirst=Kevin&rft.date=2006-02-01&rft.volume=19&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolutionary analysis of a large mtDNA translocation (numt) into the nuclear genome of the Panthera genus species. AN - 67665326; 16380222 AB - Translocation of cymtDNA into the nuclear genome, also referred to as numt, has been reported in many species, including several closely related to the domestic cat (Felis catus). We describe the recent transposition of 12,536 bp of the 17 kb mitochondrial genome into the nucleus of the common ancestor of the five Panthera genus species: tiger, P. tigris; snow leopard, P. uncia; jaguar, P. onca; leopard, P. pardus; and lion, P. leo. This nuclear integration, representing 74% of the mitochondrial genome, is one of the largest to be reported in eukaryotes. The Panthera genus numt differs from the numt previously described in the Felis genus in: (1) chromosomal location (F2-telomeric region vs. D2-centromeric region), (2) gene make up (from the ND5 to the ATP8 vs. from the CR to the COII), (3) size (12.5 vs. 7.9 kb), and (4) structure (single monomer vs. tandemly repeated in Felis). These distinctions indicate that the origin of this large numt fragment in the nuclear genome of the Panthera species is an independent insertion from that of the domestic cat lineage, which has been further supported by phylogenetic analyses. The tiger cymtDNA shared around 90% sequence identity with the homologous numt sequence, suggesting an origin for the Panthera numt at around 3.5 million years ago, prior to the radiation of the five extant Panthera species. JF - Gene AU - Kim, Jae-Heup AU - Antunes, Agostinho AU - Luo, Shu-Jin AU - Menninger, Joan AU - Nash, William G AU - O'Brien, Stephen J AU - Johnson, Warren E AD - Laboratory of Genomic Diversity, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC), Frederick, MD 21702-1201, USA. Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 292 EP - 302 VL - 366 IS - 2 SN - 0378-1119, 0378-1119 KW - DNA, Mitochondrial KW - 0 KW - Index Medicus KW - Animals KW - Cats KW - Mutagenesis, Insertional -- genetics KW - Phylogeny KW - Translocation, Genetic -- genetics KW - Genome -- genetics KW - Panthera -- genetics KW - Chromosomes -- genetics KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67665326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Evolutionary+analysis+of+a+large+mtDNA+translocation+%28numt%29+into+the+nuclear+genome+of+the+Panthera+genus+species.&rft.au=Kim%2C+Jae-Heup%3BAntunes%2C+Agostinho%3BLuo%2C+Shu-Jin%3BMenninger%2C+Joan%3BNash%2C+William+G%3BO%27Brien%2C+Stephen+J%3BJohnson%2C+Warren+E&rft.aulast=Kim&rft.aufirst=Jae-Heup&rft.date=2006-02-01&rft.volume=366&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genomics. 1999 Aug 15;60(1):67-77 [10458912] PLoS Biol. 2004 Dec;2(12):e442 [15583716] Mol Biol Evol. 2005 Apr;22(4):991-1000 [15647517] J Biol Chem. 2000 Sep 29;275(39):30144-52 [10899162] Trends Genet. 2001 Jul;17(7):383-7 [11418217] Science. 2001 Jun 22;292(5525):2264-6 [11423643] Mol Biol Evol. 2001 Sep;18(9):1833-7 [11504863] Bioinformatics. 2001 Dec;17(12):1244-5 [11751241] J Biol Chem. 2002 Feb 22;277(8):6051-8 [11744727] Genome Res. 2002 Jun;12(6):885-93 [12045142] Genomics. 2002 Jul;80(1):71-7 [12079285] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9905-12 [12119382] J Mol Evol. 2003 Feb;56(2):169-74 [12574863] Nucleic Acids Res. 2003 Jul 1;31(13):3406-15 [12824337] J Mol Evol. 2003 Sep;57(3):343-54 [14629044] Mol Ecol. 2004 Feb;13(2):321-35 [14717890] Hum Mutat. 2004 Feb;23(2):125-33 [14722916] Mol Biol Evol. 2004 Jun;21(6):1081-4 [15014143] BMC Evol Biol. 2004 Jun 25;4:17 [15219233] PLoS Biol. 2004 Sep;2(9):E273 [15361937] Nature. 1981 Apr 9;290(5806):457-65 [7219534] Nature. 1981 Jul 16;292(5820):237-9 [7254315] J Mol Evol. 1982;18(4):225-39 [6284948] Nature. 1983 Feb 17-23;301(5901):631-4 [6298629] Virology. 1983 Apr 15;126(1):32-50 [6302989] Proc Natl Acad Sci U S A. 1985 Jan;82(2):351-5 [2982153] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4443-7 [3892535] J Mol Evol. 1985;22(2):160-74 [3934395] Mol Cell Biol. 1985 Oct;5(10):2599-607 [3016509] Mol Biol Evol. 1987 Jul;4(4):406-25 [3447015] Gene Anal Tech. 1987 Jul-Aug;4(4):75-85 [3507390] Trends Genet. 1989 May;5(5):149-54 [2667219] Proc Natl Acad Sci U S A. 1989 Aug;86(16):6196-200 [2762322] Science. 1990 Jan 5;247(4938):64-9 [2294592] Curr Opin Genet Dev. 1992 Dec;2(6):918-25 [1282405] J Mol Evol. 1994 Aug;39(2):174-90 [7932781] Zoolog Sci. 1994 Aug;11(4):597-604 [7765500] J Mol Evol. 1995 Jun;40(6):652-7 [7543951] Proc Biol Sci. 1995 Oct 23;262(1363):13-9 [7479989] Nature. 1995 Nov 30;378(6556):485-9 [7477403] Mol Biol Evol. 1996 May;13(5):650-9 [8676739] Mol Ecol. 1996 Apr;5(2):295-300 [8673275] Curr Biol. 1996 Feb 1;6(2):128-9 [8673455] Genomics. 1996 Apr 15;33(2):229-46 [8660972] J Mol Evol. 1996 Dec;43(6):641-9 [8995061] Mol Biol Evol. 1997 Mar;14(3):277-86 [9066795] J Mol Evol. 1997;44 Suppl 1:S98-116 [9071018] Comput Appl Biosci. 1997 Oct;13(5):555-6 [9367129] Nucleic Acids Res. 1997 Dec 15;25(24):4876-82 [9396791] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Has the amyloid cascade hypothesis for Alzheimer's disease been proved? AN - 67649817; 16472206 AB - After much initial debate for and against the role of amyloid in Alzheimer's disease (AD), mutations on the amyloid precursor protein (APP) and processing pathways that increase levels of the amyloid b peptide of 42 residues (Abeta42) have established that faulty function or processing of these proteins are responsible for AD pathogenesis. Given the neurotoxicity of aggregates of Ab42, the central role of this peptide in AD pathogenesis is self evident. In this article, I summarize the major pieces of evidence adduced to support the amyloid cascade hypothesis and point out their limitations. JF - Current Alzheimer research AU - Hardy, John AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1015, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892-3707, USA. hardyj@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 71 EP - 73 VL - 3 IS - 1 SN - 1567-2050, 1567-2050 KW - Amyloid KW - 0 KW - Amyloid beta-Peptides KW - Amyloid beta-Protein Precursor KW - Apolipoproteins E KW - Peptide Fragments KW - amyloid beta-protein (1-42) KW - tau Proteins KW - Index Medicus KW - Animals KW - tau Proteins -- metabolism KW - Neurofibrillary Tangles -- pathology KW - Apolipoproteins E -- metabolism KW - Immunotherapy KW - Humans KW - tau Proteins -- genetics KW - Mice KW - Mice, Transgenic KW - Amyloid beta-Protein Precursor -- genetics KW - Immunization KW - Peptide Fragments -- toxicity KW - Amyloid beta-Peptides -- genetics KW - Alzheimer Disease -- genetics KW - Peptide Fragments -- genetics KW - Amyloid beta-Peptides -- toxicity KW - Alzheimer Disease -- physiopathology KW - Amyloid beta-Peptides -- physiology KW - Amyloid -- genetics KW - Amyloid -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67649817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Has+the+amyloid+cascade+hypothesis+for+Alzheimer%27s+disease+been+proved%3F&rft.au=Hardy%2C+John&rft.aulast=Hardy&rft.aufirst=John&rft.date=2006-02-01&rft.volume=3&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2006-02-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Curr Alzheimer Res. 2006 Feb;3(1):75-80 [16472207] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional genomics of hepatocellular carcinoma. AN - 67646795; 16447291 AB - The majority of DNA-microarray based gene expression profiling studies on human hepatocellular carcinoma (HCC) has focused on identifying genes associated with clinicopathological features of HCC patients. Although notable success has been achieved, this approach still faces significant challenges due to the heterogeneous nature of HCC (and other cancers) as well as the many confounding factors embedded in gene expression profile data. However, these limitations are being overcome by improved bioinformatics and sophisticated analyses. Also, application of cross comparison of multiple gene expression data sets from human tumors and animal models are facilitating the identification of critical regulatory modules in the expression profiles. The success of this new experimental approach, comparative functional genomics, suggests that integration of independent data sets will enhance our ability to identify key regulatory elements in tumor development. Furthermore, integrating gene expression profiles with data from DNA sequence information in promoters, array-based CGH, and expression of non-coding genes (i.e., microRNAs) will further increase the reliability and significance of the biological and clinical inferences drawn from the data. The pace of current progress in the cancer profiling field, combined with the advances in high-throughput technologies in genomics and proteomics, as well as in bioinformatics, promises to yield unprecedented biological insights from the integrative (or systems) analysis of the combined cancer genomics database. The predicted beneficial impact of this "new integrative biology" on diagnosis, treatment and prevention of liver cancer and indeed cancer in general is enormous. JF - Hepatology (Baltimore, Md.) AU - Thorgeirsson, Snorri S AU - Lee, Ju-Seog AU - Grisham, Joe W AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. snorri_thorgeirsson@nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - S145 EP - S150 VL - 43 IS - 2 Suppl 1 SN - 0270-9139, 0270-9139 KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Genomics -- methods KW - Humans KW - Mice KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67646795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Functional+genomics+of+hepatocellular+carcinoma.&rft.au=Thorgeirsson%2C+Snorri+S%3BLee%2C+Ju-Seog%3BGrisham%2C+Joe+W&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2006-02-01&rft.volume=43&rft.issue=2+Suppl+1&rft.spage=S145&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. AN - 67644814; 16102138 AB - Certain Phthalate esters have been shown to produce reproductive toxicity in male rodents with an age dependent sensitivity in effects with foetal animals being more sensitive than neonates which are in turn more sensitive than pubertal and adult animals. While the testicular effects of phthalates in rats have been known for more than 30 years, recent attention has been focused on the ability of these agents to produce effects on reproductive development in male offspring after in utero exposure. These esters and in particular di-butyl, di-(2-ethylhexyl) and butyl benzyl phthalates have been shown to produce a syndrome of reproductive abnormalities characterized by malformations of the epididymis, vas deferens, seminal vesicles, prostate, external genitalia (hypospadias), cryptorchidism and testicular injury together with permanent changes (feminization) in the retention of nipples/areolae (sexually dimorphic structures in rodents) and demasculinization of the growth of the perineum resulting in a reduced anogenital distance (AGD). Critical to the induction of these effects is a marked reduction in foetal testicular testosterone production at the critical window for the development of the reproductive tract normally under androgen control. A second Leydig cell product, insl3, is also significantly down regulated and is likely responsible for the cryptorchidism commonly seen in these phthalate-treated animals. The testosterone decrease is mediated by changes in gene expression of a number of enzymes and transport proteins involved in normal testosterone biosynthesis and transport in the foetal Leydig cell. Alterations in the foetal seminiferous cords are also noted after in utero phthalate treatment with the induction of multinucleate gonocytes that contribute to lowered spermatocyte numbers in postnatal animals. The phthalate syndrome of effects on reproductive development has parallels with the reported human testicular dysgenesis syndrome, although no cause and effect relationship exists after exposure of humans to phthalate esters. However humans are exposed to and produce the critical phthalate metabolites that have been detected in blood of the general population, in children and also human amniotic fluid. JF - International journal of andrology AU - Foster, Paul M D AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. foster2@niehs.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 140 EP - 7; discussion 181-5 VL - 29 IS - 1 SN - 0105-6263, 0105-6263 KW - Esters KW - 0 KW - Phthalic Acids KW - Index Medicus KW - Rats KW - Animals KW - Models, Biological KW - Embryo, Mammalian -- drug effects KW - Male KW - Female KW - Pregnancy KW - Genitalia, Male -- embryology KW - Genitalia, Male -- drug effects KW - Phthalic Acids -- pharmacology KW - Genitalia, Male -- pathology KW - Esters -- pharmacology KW - Genitalia, Male -- growth & development KW - Maternal Exposure KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67644814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+andrology&rft.atitle=Disruption+of+reproductive+development+in+male+rat+offspring+following+in+utero+exposure+to+phthalate+esters.&rft.au=Foster%2C+Paul+M+D&rft.aulast=Foster&rft.aufirst=Paul+M&rft.date=2006-02-01&rft.volume=29&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=International+journal+of+andrology&rft.issn=01056263&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model. AN - 67636446; 16459181 AB - Gene transfer to hematopoietic stem cells has recently been demonstrated to benefit a small number of patients in whom a selective advantage is conferred upon genetically modified cells; however, in disorders where no such selective advantage is conferred, conditioning appears necessary to allow adequate engraftment. To decrease the toxicity profile, we sought to develop nonmyeloablative conditioning regimens and in this work, explored the use of intravenous busulfan in a large animal model. Busulfan pharmacokinetics and toxicity were monitored in young rhesus macaques at two dosing levels (4 and 6 mg/kg). These doses were then employed to condition two animals at each dose level prior to autologous transplantation of genetically modified cells using our standard methods. Busulfan pharmacokinetic (PK) data showed the area under the curve (AUC), drug half-life, and drug clearance were consistent within each dose group and similar to those reported in children. Single doses of busulfan were well tolerated and produced dose-dependent myelosuppression, most notably in the neutrophil and platelet counts. Although marking levels reached over 1% early in one animal, the long-term marking was low but detectable at 0.01 to 0.001%. We conclude that low-dose intravenous bolus infusion of busulfan is well tolerated, has dose-dependent effects on peripheral blood counts, and allows long-term engraftment of genetically modified cells, but at levels too low for most clinical disorders. JF - Experimental hematology AU - Kang, Elizabeth M AU - Hsieh, Matthew M AU - Metzger, Mark AU - Krouse, Allen AU - Donahue, Robert E AU - Sadelain, Michel AU - Tisdale, John F AD - Laboratory of Host Defense, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 132 EP - 139 VL - 34 IS - 2 SN - 0301-472X, 0301-472X KW - Busulfan KW - G1LN9045DK KW - Index Medicus KW - Animals KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Macaca mulatta KW - Transplantation, Autologous KW - Busulfan -- administration & dosage KW - Transplantation Conditioning -- methods KW - Hematopoietic Stem Cells -- physiology KW - Busulfan -- toxicity KW - Busulfan -- pharmacokinetics KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67636446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Busulfan+pharmacokinetics%2C+toxicity%2C+and+low-dose+conditioning+for+autologous+transplantation+of+genetically+modified+hematopoietic+stem+cells+in+the+rhesus+macaque+model.&rft.au=Kang%2C+Elizabeth+M%3BHsieh%2C+Matthew+M%3BMetzger%2C+Mark%3BKrouse%2C+Allen%3BDonahue%2C+Robert+E%3BSadelain%2C+Michel%3BTisdale%2C+John+F&rft.aulast=Kang&rft.aufirst=Elizabeth&rft.date=2006-02-01&rft.volume=34&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Apr 28;288(5466):669-72 [10784449] Biol Blood Marrow Transplant. 2004 Sep;10(9):614-23 [15319773] Blood. 2000 Jul 1;96(1):1-8 [10891424] Mol Ther. 2000 Mar;1(3):285-93 [10933944] Mol Ther. 2000 Jun;1(6):533-44 [10933978] Exp Hematol. 2001 Jun;29(6):779-85 [11378274] Mol Ther. 2001 Jun;3(6):911-9 [11407905] Blood. 2001 Oct 15;98(8):2352-7 [11588030] Science. 2001 Dec 14;294(5550):2368-71 [11743206] Biol Blood Marrow Transplant. 2001;7(12):665-73 [11787529] N Engl J Med. 2002 Apr 18;346(16):1185-93 [11961146] Biol Blood Marrow Transplant. 2002;8(9):468-76 [12374451] Biol Blood Marrow Transplant. 2002;8(9):486-92 [12374453] Biol Blood Marrow Transplant. 2002;8(9):493-500 [12374454] Biol Blood Marrow Transplant. 2004 Nov;10(11):805-12 [15505611] Transplantation. 1968 Mar;6(2):299-302 [5654091] Blood. 1974 Jul;44(1):49-56 [4834516] J Natl Cancer Inst. 1974 Dec;53(6):1781-5 [4612168] Proc Natl Acad Sci U S A. 1982 Aug;79(16):5085-7 [6750615] N Engl J Med. 1983 Dec 1;309(22):1347-53 [6355849] Exp Hematol. 1984 May;12(4):277-83 [6370711] Transplantation. 1987 Oct;44(4):487-94 [2890226] Transplantation. 1988 Aug;46(2):205-10 [3043777] Cancer Chemother Pharmacol. 1989;25(1):55-61 [2591002] Exp Hematol. 1993 Apr;21(4):585-91 [7681785] Blood. 1993 May 15;81(10):2566-71 [8098231] Stem Cells. 2004;22(6):1062-9 [15536196] Bone Marrow Transplant. 2005 Jan;35(1):17-23 [15502853] Blood. 1994 Oct 1;84(7):2357-62 [7919354] Science. 1995 Oct 20;270(5235):470-5 [7570000] Nat Med. 1995 Oct;1(10):1017-23 [7489356] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12133-8 [9342375] Blood. 1998 Aug 15;92(4):1131-41 [9694700] Blood. 1998 Sep 15;92(6):1878-86 [9731044] Gene Ther. 1999 Jun;6(6):966-72 [10455398] Blood. 1999 Oct 1;94(7):2271-86 [10498599] Blood. 1999 Oct 1;94(7):2287-92 [10498600] Lancet. 1953 Jan 31;264(6753):207-8 [13097986] Lancet. 1953 Jan 31;264(6753):208-13 [13097987] Biol Blood Marrow Transplant. 1999;5(5):316-21 [10534062] Exp Hematol. 2003 Feb;31(2):176-84 [12591283] Blood. 2003 Mar 15;101(6):2175-83 [12411297] Blood. 2003 Mar 15;101(6):2199-205 [12424191] Blood. 2003 Apr 15;101(8):2932-9 [12480689] Nat Rev Cancer. 2003 Jul;3(7):477-88 [12835668] Science. 2003 Oct 17;302(5644):415-9 [14564000] Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):461-6 [14612670] Blood. 2003 Dec 15;102(13):4312-9 [12933581] Blood. 2003 Dec 15;102(13):4582-93 [12933586] Mol Ther. 2004 Mar;9(3):389-95 [15006605] Exp Hematol. 2004 Feb;32(2):163-70 [15102477] Blood. 2004 Sep 1;104(5):1273-80 [15126320] Nature. 2000 Jul 6;406(6791):82-6 [10894546] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. AN - 67627499; 16390920 AB - We sought to determine if an association exists between the use of histamine-2 receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401 to 1500 g in birth weight. Data from the National Institute of Child Health and Human Development Neonatal Research Network very low birth weight (401-1500 g) registry from September 1998 to December 2001 were analyzed. The relation between the diagnosis of NEC (Bell stage II or greater) and antecedent H2-blocker treatment was determined by using case-control methodology. Conditional logistic regression was implemented, controlling for gender, site of birth (outborn versus inborn), Apgar score of < 7 at 5 minutes, and postnatal steroids. Of 11072 infants who survived for at least 12 hours, 787 (7.1%) developed NEC (11.5% of infants 401-750 g, 9.1% of infants 751-1000 g, 6.0% of infants 1001-1250 g, and 3.9% of infants 1251-1500 g). Antecedent H2-blocker use was associated with an increased incidence of NEC (P < .0001). H2-blocker therapy was associated with higher rates of NEC, which is in agreement with a previous randomized trial of acidification of infant feeds that resulted in a decreased incidence of NEC. In combination, these data support the hypothesis that gastric pH level may be a factor in the pathogenesis of NEC. JF - Pediatrics AU - Guillet, Ronnie AU - Stoll, Barbara J AU - Cotten, C Michael AU - Gantz, Marie AU - McDonald, Scott AU - Poole, W Kenneth AU - Phelps, Dale L AU - National Institute of Child Health and Human Development Neonatal Research Network AD - Division of Neonatology, Department of Pediatrics, University of Rochester, Rochester, New York, USA. ronnie_guillet@urmc.rochester.edu ; National Institute of Child Health and Human Development Neonatal Research Network Y1 - 2006/02// PY - 2006 DA - February 2006 SP - e137 EP - e142 VL - 117 IS - 2 KW - Histamine H2 Antagonists KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Case-Control Studies KW - Male KW - Female KW - Infant, Very Low Birth Weight KW - Histamine H2 Antagonists -- adverse effects KW - Enterocolitis, Necrotizing -- chemically induced KW - Histamine H2 Antagonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67627499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Association+of+H2-blocker+therapy+and+higher+incidence+of+necrotizing+enterocolitis+in+very+low+birth+weight+infants.&rft.au=Guillet%2C+Ronnie%3BStoll%2C+Barbara+J%3BCotten%2C+C+Michael%3BGantz%2C+Marie%3BMcDonald%2C+Scott%3BPoole%2C+W+Kenneth%3BPhelps%2C+Dale+L%3BNational+Institute+of+Child+Health+and+Human+Development+Neonatal+Research+Network&rft.aulast=Guillet&rft.aufirst=Ronnie&rft.date=2006-02-01&rft.volume=117&rft.issue=2&rft.spage=e137&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pediatrics. 2006 Oct;118(4):1794-5; author reply 1795-6 [17015576] Pediatrics. 2006 Feb;117(2):531-2 [16452376] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment. AN - 67626562; 16452187 AB - Transplacental inorganic arsenic carcinogenicity, together with postnatal exposure to diethylstilbestrol or tamoxifen, was studied. Pregnant CD1 mice received 85 ppm arsenic in the drinking water from gestation days 8 to 18 and were allowed to give birth. Groups (n = 35) of female offspring were injected s.c. on postpartum days 1 through 5 with diethylstilbestrol (2 microg/pup/d) or tamoxifen (10 microg/pup/d) and observed for 90 weeks. Arsenic alone induced some urogenital system tumors, including mostly benign tumors of the ovary and uterus, and adrenal adenoma. Diethylstilbestrol alone induced some tumors (primarily cervical) but when given after in utero arsenic, it greatly enhanced urogenital tumor incidence, multiplicity, and progression. For instance, compared with the incidence of urogenital malignancies in the control (0%), arsenic alone (9%), and diethylstilbestrol alone (21%) groups, arsenic plus diethylstilbestrol acted synergistically, inducing a 48% incidence of malignant urogenital tumors. Of the urogenital tumors induced by arsenic plus diethylstilbestrol, 80% were malignant, and 55% were multiple site. Arsenic plus diethylstilbestrol increased ovarian, uterine, and vaginal tumors, and urinary bladder proliferative lesions, including three transitional cell carcinomas. Tamoxifen alone did not increase urogenital tumors or affect arsenic-induced neoplasia but did increase arsenic-induced uroepithelial proliferative lesions. Uterine and bladder carcinoma induced by arsenic plus diethylstilbestrol greatly overexpressed estrogen receptor-alpha (ER-alpha) and pS2, an estrogen-regulated gene. In neonatal uteri, prenatal arsenic increased ER-alpha expression and enhanced estrogen-related gene expression induced by postnatal diethylstilbestrol. Thus, arsenic acts with estrogens to enhance production of female mouse urogenital cancers. JF - Cancer research AU - Waalkes, Michael P AU - Liu, Jie AU - Ward, Jerrold M AU - Powell, Douglas A AU - Diwan, Bhalchandra A AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. waalkes@niehs.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1337 EP - 1345 VL - 66 IS - 3 SN - 0008-5472, 0008-5472 KW - Estrogen Receptor alpha KW - 0 KW - Tamoxifen KW - 094ZI81Y45 KW - Diethylstilbestrol KW - 731DCA35BT KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Estrogen Receptor alpha -- biosynthesis KW - Gene Expression -- drug effects KW - Tamoxifen -- toxicity KW - Animals KW - Mice KW - Uterus -- drug effects KW - Pregnancy KW - Uterus -- metabolism KW - Maternal-Fetal Exchange KW - Estrogen Receptor alpha -- genetics KW - Drinking -- drug effects KW - Uterus -- physiology KW - Body Weight -- drug effects KW - Drug Synergism KW - Female KW - Genital Neoplasms, Female -- metabolism KW - Kidney Neoplasms -- pathology KW - Genital Neoplasms, Female -- pathology KW - Urinary Bladder Neoplasms -- pathology KW - Arsenic -- toxicity KW - Kidney Neoplasms -- chemically induced KW - Diethylstilbestrol -- toxicity KW - Kidney Neoplasms -- metabolism KW - Urinary Bladder Neoplasms -- metabolism KW - Urinary Bladder Neoplasms -- chemically induced KW - Prenatal Exposure Delayed Effects KW - Genital Neoplasms, Female -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67626562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Urogenital+carcinogenesis+in+female+CD1+mice+induced+by+in+utero+arsenic+exposure+is+exacerbated+by+postnatal+diethylstilbestrol+treatment.&rft.au=Waalkes%2C+Michael+P%3BLiu%2C+Jie%3BWard%2C+Jerrold+M%3BPowell%2C+Douglas+A%3BDiwan%2C+Bhalchandra+A&rft.aulast=Waalkes&rft.aufirst=Michael&rft.date=2006-02-01&rft.volume=66&rft.issue=3&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-21 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo. AN - 67609757; 16289015 AB - One of the important pathways of resistance to anthracyclines is governed by elevated levels of glutathione (GSH) in cancer cells. Resistant cells having elevated levels of GSH show higher expression of multidrug-resistant protein (MRP); the activity of glutathione S-transferases (GSTs) group of enzymes have also been found to be higher in some drug-resistant cells. The general mechanism in this type of resistance seems to be the formation of conjugates enzymatically by GSTs, and subsequent efflux by active transport through MRP (MRP1-MRP9). MRPs act as drug efflux pump and can also co-transport drugs like doxorubicin (Dox) with GSH. Depletion of GSH in resistant neoplastic cells may possibly sensitize such cells, and thus overcome multidrug resistance (MDR). A number of resistance modifying agents (RMA) like DL-buthionine (S, R) sulfoxamine (BSO) and ethacrynic acid (EA) moderately modulate resistance by acting as a GSH-depleting agent. As most of the GSH-depleting agents have dose-related toxicity, development of non-toxic GSH-depleting agent has immense importance in overcoming MDR. The present study describes the resistance reversal potentiality of novel copper complex, viz., copper N-(2-hydroxy acetophenone) glycinate (CuNG) developed by us in Dox-resistant Ehrlich ascites carcinoma (EAC/Dox) cells. CuNG depletes GSH in resistant (EAC/Dox) cells possibly by forming conjugate with it. Depletion of GSH results in higher Dox accumulation that may lead to enhanced rate of apoptosis in EAC/Dox cells. In vivo studies with male Swiss albino mice bearing ascitic growth of EAC/Dox showed tremendous increase in life span (treated/control, T/C = 453%) for the treated group with apparent regression of tumor. Resistance to Dox in EAC/Dox cells is associated with over expression of GST-P1, GST-M1 (enzymes involved in phase II detoxification) and MRP1 (a transmembrane ATPase efflux pump for monoglutathionyl conjugates of xenobiotics). CuNG causes down regulation of all these three proteins in EAC/Dox cells. The effect of CuNG as RMA is better than BSO in many aspects. JF - Chemico-biological interactions AU - Majumder, S AU - Dutta, P AU - Mookerjee, A AU - Choudhuri, S K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India. Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 90 EP - 103 VL - 159 IS - 2 SN - 0009-2797, 0009-2797 KW - Antineoplastic Agents KW - 0 KW - Copper KW - 789U1901C5 KW - Doxorubicin KW - 80168379AG KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Blotting, Western KW - Enzyme Activation KW - Glutathione -- metabolism KW - Glutathione Transferase -- metabolism KW - Mice KW - Drug Resistance, Neoplasm KW - Male KW - Caspases -- metabolism KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Doxorubicin -- therapeutic use KW - Copper -- pharmacology KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67609757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=The+role+of+a+novel+copper+complex+in+overcoming+doxorubicin+resistance+in+Ehrlich+ascites+carcinoma+cells+in+vivo.&rft.au=Majumder%2C+S%3BDutta%2C+P%3BMookerjee%2C+A%3BChoudhuri%2C+S+K&rft.aulast=Majumder&rft.aufirst=S&rft.date=2006-02-01&rft.volume=159&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. AN - 67603851; 16391839 AB - Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of cell dysfunction and tissue injury in various pathophysiological conditions associated with oxidative and nitrosative stress, including myocardial reperfusion injury, heart transplantation, diabetic cardiomyopathy and chronic heart failure. In recent studies, we have demonstrated the beneficial effects of a novel ultrapotent PARP inhibitor, INO-1001, on cardiac and endothelial dysfunction and remodeling in rat model of advanced aging-associated chronic heart failure and in a mouse model of heart failure induced by aortic banding. In the current study, we have investigated the effect of INO-1001 on the development of heart failure induced by permanent ligation of the left anterior descending coronary artery, heart failure induced by doxorubicin and acute myocardial dysfunction induced by bacterial endotoxin. In the coronary ligation model, a significantly depressed left ventricular performance and impaired vascular relaxation of aortic rings were found, and PARP inhibition significantly improved both cardiac function and vascular relaxation. In the doxorubicin model, a single injection of doxorubicin induced high mortality and a significant decrease in left ventricular systolic pressure, +dP/dt, -dP/dt, stroke volume, stroke work, ejection fraction and cardiac output. Treatment with the PARP inhibitor reduced doxorubicin-induced mortality and markedly improved cardiac function. PARP inhibition did not interfere with doxorubicin's antitumor effect. In the endotoxin model of cardiac dysfunction, PARP inhibition attenuated the suppression of myocardial contractility elicited by endotoxin. The current data strengthen the view that PARP inhibition may represent an effective approach for the experimental therapy of various forms of acute and chronic heart failure. JF - International journal of molecular medicine AU - Pacher, Pál AU - Liaudet, Lucas AU - Mabley, Jon G AU - Cziráki, Attila AU - Haskó, György AU - Szabó, Csaba AD - National Institutes of Health, NAAA, Bethesda, MD 20892-9413, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 369 EP - 375 VL - 17 IS - 2 SN - 1107-3756, 1107-3756 KW - Enzyme Inhibitors KW - 0 KW - INO 1001 KW - Indoles KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Doxorubicin KW - 80168379AG KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Index Medicus KW - Coronary Vessels -- metabolism KW - Animals KW - Survival Rate KW - Doxorubicin -- pharmacology KW - Mice KW - Coronary Vessels -- drug effects KW - Mice, Inbred BALB C KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Male KW - Heart Diseases -- drug therapy KW - Enzyme Inhibitors -- therapeutic use KW - Heart Diseases -- chemically induced KW - Heart Diseases -- enzymology KW - Enzyme Inhibitors -- pharmacology KW - Disease Models, Animal KW - Indoles -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67603851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+molecular+medicine&rft.atitle=Beneficial+effects+of+a+novel+ultrapotent+poly%28ADP-ribose%29+polymerase+inhibitor+in+murine+models+of+heart+failure.&rft.au=Pacher%2C+P%C3%A1l%3BLiaudet%2C+Lucas%3BMabley%2C+Jon+G%3BCzir%C3%A1ki%2C+Attila%3BHask%C3%B3%2C+Gy%C3%B6rgy%3BSzab%C3%B3%2C+Csaba&rft.aulast=Pacher&rft.aufirst=P%C3%A1l&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=International+journal+of+molecular+medicine&rft.issn=11073756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2002 Sep 4;40(5):1006-16 [12225730] J Pharmacol Exp Ther. 2002 Mar;300(3):862-7 [11861791] Diabetes. 2002 Feb;51(2):514-21 [11812763] Biochem Pharmacol. 2002 Dec 15;64(12):1785-91 [12445868] Circulation. 2003 Feb 18;107(6):896-904 [12591762] Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L240-9 [12626333] J Am Coll Surg. 2003 Aug;197(2):270-7 [12892811] J Clin Invest. 2003 Oct;112(7):1049-57 [14523042] Oncol Rep. 2004 Feb;11(2):505-8 [14719091] Shock. 2004 Feb;21(2):126-33 [14752285] Int J Mol Med. 2004 Mar;13(3):373-82 [14767566] Shock. 2004 Mar;21(3):230-4 [14770035] Shock. 2004 May;21(5):426-32 [15087818] Curr Pharm Des. 2004;10(14):1699-711 [15134567] Ann Thorac Surg. 2004 Jun;77(6):1938-43 [15172241] J Pharmacol Exp Ther. 2004 Aug;310(2):498-504 [15054118] Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H595-600 [15059774] J Pharmacol Exp Ther. 2004 Nov;311(2):485-91 [15213249] Mol Med. 2004 Jan-Jun;10(1-6):28-35 [15502880] Crit Care Med. 2004 Dec;32(12):2392-7 [15599141] Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H486-96 [15374823] Biochem J. 2005 Feb 15;386(Pt 1):119-25 [15456408] Biochem Pharmacol. 2005 Mar 1;69(5):725-32 [15710350] J Pharmacol Exp Ther. 2005 Mar;312(3):891-8 [15523000] Nat Rev Drug Discov. 2005 May;4(5):421-40 [15864271] Cell Mol Life Sci. 2005 Apr;62(7-8):769-83 [15868402] Trends Pharmacol Sci. 2005 Jun;26(6):302-10 [15925705] Curr Vasc Pharmacol. 2005 Jul;3(3):221-9 [16026319] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prolactin induced reversal of glucocorticoid mediated apoptosis of immature cortical thymocytes is abrogated by induction of tumor. AN - 67595236; 16289331 AB - Glucocorticoid (GC) and prolactin (PRL) are the two neuroendocrines that regulate thymocyte differentiation and maintain the immune homeostasis during stress. We found that dexamethasone (Dex), a synthetic GC, induced apoptosis in normal immature cortical thymocytes which remained unaltered in the presence of Elrich's ascitic carcinoma (EAC). PRL protected the normal CD4+ CD8+ cortical thymocytes from Dex-induced apoptosis but failed to alter the effect of Dex in tumor-bearing mice. Dex-treated normal thymocytes became unresponsive to PRL in presence of tumor cell culture supernatant. Low binding affinity of the microsomal membranes of thymocytes to PRL and absence of the mRNA of a particular form of prolactin receptor (PRL-R) suggest the presence of a different PRL-R in CD4+ CD8+ thymocytes of EAC-bearing mice. The induction of tumor may alter the PRL-R that can be correlated with the failure of PRL in rescuing CD4+ CD8+ immature cortical thymocytes from GC induced death. JF - Journal of neuroimmunology AU - Biswas, Ratna AU - Roy, Tanima AU - Chattopadhyay, Utpala AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata-700 026, India. immuneprolactin@yahoo.com.in Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 120 EP - 134 VL - 171 IS - 1-2 SN - 0165-5728, 0165-5728 KW - Anti-Inflammatory Agents KW - 0 KW - Antibodies KW - Culture Media, Conditioned KW - Glucocorticoids KW - Proto-Oncogene Proteins c-bcl-2 KW - RNA, Messenger KW - Dexamethasone KW - 7S5I7G3JQL KW - Prolactin KW - 9002-62-4 KW - Index Medicus KW - Culture Media, Conditioned -- pharmacology KW - Animals KW - Drug Interactions KW - Neoplasm Transplantation -- methods KW - Blotting, Southern -- methods KW - Dose-Response Relationship, Drug KW - Dexamethasone -- pharmacology KW - Mice KW - Blotting, Western -- methods KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Flow Cytometry -- methods KW - RNA, Messenger -- metabolism KW - Cell Count -- methods KW - Antibodies -- pharmacology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Blotting, Northern -- methods KW - Female KW - Anti-Inflammatory Agents -- pharmacology KW - Thymus Gland -- growth & development KW - Thymus Gland -- cytology KW - Neoplasms -- pathology KW - T-Lymphocyte Subsets -- drug effects KW - T-Lymphocyte Subsets -- immunology KW - Apoptosis -- drug effects KW - Neoplasms -- physiopathology KW - Prolactin -- pharmacology KW - Thymus Gland -- drug effects KW - Prolactin -- immunology KW - Glucocorticoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmunology&rft.atitle=Prolactin+induced+reversal+of+glucocorticoid+mediated+apoptosis+of+immature+cortical+thymocytes+is+abrogated+by+induction+of+tumor.&rft.au=Biswas%2C+Ratna%3BRoy%2C+Tanima%3BChattopadhyay%2C+Utpala&rft.aulast=Biswas&rft.aufirst=Ratna&rft.date=2006-02-01&rft.volume=171&rft.issue=1-2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmunology&rft.issn=01655728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bromocriptine treatment for cocaine addiction: association with plasma prolactin levels. AN - 67590978; 16051446 AB - Bromocriptine is a dopamine receptor agonist used with mixed success in the treatment of cocaine addiction. Variations in dopamine receptor sensitivity may help account for these differences. We evaluated this question in a 24-week outpatient controlled clinical trial in 70 cocaine-abusing (DSM-III) men (86% African-American, mean age 34 years, mean 39 months of regular cocaine use [predominantly smoked]). Subjects received 4 weeks of inpatient treatment. During the last 2 weeks they were inducted onto bromocriptine (maximum dose 2.5mg po tid) (n=35) or placebo (n=35). Plasma prolactin concentrations were assayed before and after the first bromocriptine dose (1.25mg po) as a measure of dopamine receptor sensitivity. After discharge, subjects continued on medication with weekly group counseling. Bromocriptine significantly suppressed prolactin concentrations (4.4 ng/ml decrease), while placebo did not (0.1 ng/ml decrease). Both groups decreased their cocaine use, with no significant group differences in retention in treatment or proportion of cocaine-positive urine samples. There was no significant association between basal plasma prolactin concentrations or prolactin response to first bromocriptine dose and either outcome measure. These data do not support the efficacy of bromocriptine treatment nor a role for prolactin concentration in predicting treatment response. JF - Drug and alcohol dependence AU - Gorelick, David A AU - Wilkins, Jeffery N AD - Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. dgorelick@intra.nida.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 189 EP - 195 VL - 81 IS - 2 SN - 0376-8716, 0376-8716 KW - Dopamine Agonists KW - 0 KW - Bromocriptine KW - 3A64E3G5ZO KW - Prolactin KW - 9002-62-4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Outpatients KW - Prolactin -- blood KW - Double-Blind Method KW - Patient Compliance KW - Humans KW - Male KW - Dopamine Agonists -- therapeutic use KW - Bromocriptine -- therapeutic use KW - Cocaine-Related Disorders -- therapy KW - Cocaine-Related Disorders -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67590978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Bromocriptine+treatment+for+cocaine+addiction%3A+association+with+plasma+prolactin+levels.&rft.au=Gorelick%2C+David+A%3BWilkins%2C+Jeffery+N&rft.aulast=Gorelick&rft.aufirst=David&rft.date=2006-02-01&rft.volume=81&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Major Increases in Opioid Analgesic Abuse in the United States: Concerns and Strategies AN - 59980247; 200609832 AB - The problem of abuse of & addiction to opioid analgesics has emerged as a major issue for the United States in the past decade & has worsened over the past few years. The increases in abuse of these opioids appear to reflect, in part, changes in medication prescribing practices, changes in drug formulations as well as relatively easy access via the internet. Though the use of opioid analgesics for the treatment of acute pain appears to be generally benign, long-term administration of opioids has been associated with clinically meaningful rates of abuse or addiction. Important areas of research to help with the problem of opioid analgesic abuse include the identification of clinical practices that minimize the risks of addiction, the development of guidelines for early detection & management of addiction, the development of opioid analgesics that minimize the risks for abuse, & the development of safe & effective non-opioid analgesics. With high rates of abuse of opiate analgesics among teenagers in the United States, a particularly urgent priority is the investigation of best practices for treating pain in adolescents as well as the development of prevention strategies to reduce diversion & abuse. Figures, References. [Copyright 2005 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Compton, Wilson M AU - Volkow, Nora D AD - National Instit Drug Abuse, Bethesda, MD wcompton@nida.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 103 EP - 107 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 81 IS - 2 SN - 0376-8716, 0376-8716 KW - Prescription drug abuse KW - Opioid analgesics KW - Drug abuse KW - Drug dependence KW - Addiction KW - Drug Addiction KW - Opiates KW - Medications KW - Drug Abuse KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59980247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Major+Increases+in+Opioid+Analgesic+Abuse+in+the+United+States%3A+Concerns+and+Strategies&rft.au=Compton%2C+Wilson+M%3BVolkow%2C+Nora+D&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2006-02-01&rft.volume=81&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.05.009 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 28 N1 - Last updated - 2016-09-28 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Opiates; Drug Abuse; Drug Addiction; Medications DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.05.009 ER - TY - JOUR T1 - Politics, culture, and governance in the development of prior informed consent in indigenous communities AN - 37726007; 3264218 JF - Current anthropology AU - Rosenthal, Joshua P AD - National Institutes of Health Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 119 EP - 142 VL - 47 IS - 1 SN - 0011-3204, 0011-3204 KW - Anthropology KW - Informed consent KW - Human rights KW - Mexico KW - Human genetics KW - Research methods KW - Bioethics KW - Biodiversity KW - Peru KW - Anthropological research KW - Indigenous populations KW - Governance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37726007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+anthropology&rft.atitle=Politics%2C+culture%2C+and+governance+in+the+development+of+prior+informed+consent+in+indigenous+communities&rft.au=Rosenthal%2C+Joshua+P&rft.aulast=Rosenthal&rft.aufirst=Joshua&rft.date=2006-02-01&rft.volume=47&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Current+anthropology&rft.issn=00113204&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6314 9846; 1069 10902; 1601 8560 9511 4309; 6081 5460 1615 8573 11325; 10919; 5549; 6103 11032 9705; 1603 4408 8282 8281 6085; 251 293 14; 329 386 14 ER - TY - JOUR T1 - Child-care effect sizes for the NICHD study of early child care and youth development AN - 37710928; 3267447 AB - This report summarizes findings from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development as effect sizes for exclusive maternal care and-for children in child care-type, quality, and quantity of care. Children (n = 1,261) were recruited at birth and assessed at 15, 24, 36, and 54 months. Exclusive maternal care did not predict child outcomes, but multiple features of child-care experience were modestly to moderately predictive. Higher quality child care was related to advanced cognitive, language, and preacademic outcomes at every age and better socio-emotional and peer outcomes at some ages. More child-care hours predicted more behavior problems and conflict, according to care providers. More center-care time was related to higher cognitive and language scores and more problem and fewer prosocial behaviors, according to care providers. Child-care effect sizes are discussed from 3 perspectives: (a) absolute effect sizes, reflecting established guidelines; (b) relative effect sizes, comparing child-care and parenting effects; and (c) possible individual and collective implications for the large numbers of children experiencing child care. Reprinted by permission of the American Psychological Association JF - American psychologist Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 99 EP - 116 VL - 61 IS - 2 SN - 0003-066X, 0003-066X KW - Sociology KW - Early childhood KW - Case studies KW - Psychology KW - Development KW - U.S.A. KW - Developmental psychology KW - Effects KW - Child care KW - Youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37710928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+psychologist&rft.atitle=Child-care+effect+sizes+for+the+NICHD+study+of+early+child+care+and+youth+development&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2006-02-01&rft.volume=61&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=American+psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2F0003-066X.61.2.99 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2192; 4109 2088 10642 2688 2449 10404; 13779 652 5676 646 6091; 3483; 3827 2211 652 5676 646 6091 2212; 2056 10902; 3518 10404; 10404; 433 293 14 DO - http://dx.doi.org/10.1037/0003-066X.61.2.99 ER - TY - JOUR T1 - Long-term cumulative effects of childcare on children's mental development and socioemotional adjustment in a non-risk sample: the moderating effects of gender AN - 36507731; 3312617 AB - We studied the long-term cumulative effects of two common indices of childcare-the total number of hours of non-maternal care and the mean hour-weighted child-to-caregiver ratio per caregiving situation-on mental development and socioemotional adjustment from birth to 4.5 years old in a non-risk middle-class sample of girls and boys after taking into consideration child (gender and sibling status), maternal (education and concepts of child development), and family selection (socioeconomic status [SES] factors. Childcare indices did not differ in girls and boys year by year. Children experienced less non-maternal care in their first year of life, but afterward children encountered more children in their caregiving situations in proportion to the number of caregivers. At age 4.5 years, girls scored higher on cognitive and language measures than boys, and boys exhibited more externalizing problem behaviors than girls. Hours of non-maternal care were not a predictor of mental development or socioemotional adjustment; however, the child-to-caregiver ratio was. For cognitive outcomes, the ratio exerted a positive effect on children from higher SES backgrounds versus no effect on children from average or lower SES backgrounds. For behavioral adjustment outcomes, a higher ratio was associated with fewer behavioral problems in girls and more behavioral problems in boys. Different basic indices of childcare appear to have different long-term cumulative effects for different domains of development in girls and boys. Reprinted by permission of Carfax Publishing, Taylor and Francis Ltd. JF - Early child development and care AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Gist, Nancy F AU - Haynes, O Maurice AD - National Institutes of Health Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 129 EP - 156 VL - 176 IS - 2 SN - 0300-4430, 0300-4430 KW - Sociology KW - Emotions KW - Child psychology KW - Gender KW - Child care KW - Developmental psychology KW - Child development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36507731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+child+development+and+care&rft.atitle=Long-term+cumulative+effects+of+childcare+on+children%27s+mental+development+and+socioemotional+adjustment+in+a+non-risk+sample%3A+the+moderating+effects+of+gender&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BGist%2C+Nancy+F%3BHaynes%2C+O+Maurice&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2006-02-01&rft.volume=176&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Early+child+development+and+care&rft.issn=03004430&rft_id=info:doi/10.1080%2F0300443042000266286 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 2205 2212 10404; 3518 10404; 5421 6091; 4196; 2192 DO - http://dx.doi.org/10.1080/0300443042000266286 ER - TY - JOUR T1 - Stability in cognition across early childhood: a developmental cascade AN - 36506938; 3310703 AB - Children confront the formidable task of assimilating information in the environment and accommodating their cognitive structures to that information. Developmental science is concerned equally with two distinctive features of these processes: children's group mean level of performance through time and the standing of individual children through time. Prevailing opinion since the inception of the mental-measurement movement has been that individual development is unstable-that individual children change unpredictably in their abilities. We report results of a large-scale controlled, multivariate, prospective, microgenetic, 4-year longitudinal study that reveals a statistically significant cascade of species-typical cognitive abilities from infancy to childhood. Infancy is a recognizable starting point of life; we find that to a small but significant degree, infancy also represents a setting point in the life of the individual. Reprinted by permission of Sage Publications JF - Psychological science AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Bell, Clare AU - Haynes, O Maurice AU - Slater, Alan AU - Golding, Jean AU - Wolke, Dieter AU - , University of Bristol AD - National Institutes of Health ; University of Bristol ; School of Psychology Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 151 EP - 158 VL - 17 IS - 2 SN - 0956-7976, 0956-7976 KW - Sociology KW - Psychology KW - Childhood KW - Developmental psychology KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36506938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Stability+in+cognition+across+early+childhood%3A+a+developmental+cascade&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BBell%2C+Clare%3BHaynes%2C+O+Maurice%3BSlater%2C+Alan%3BGolding%2C+Jean%3BWolke%2C+Dieter%3B%2C+University+of+Bristol&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2449 10404; 2211 652 5676 646 6091 2212; 3518 10404; 10404 ER - TY - JOUR T1 - Phase I Trial of Bortezomib in Combination with Docetaxel in Patients with Advanced Solid Tumors AN - 21291234; 6717994 AB - PURPOSE: Bortezomib (PS-341), a first-in-class proteasome inhibitor, is metabolized by deboronation involving cytochrome P4503A (CYP3A), which also metabolizes docetaxel. Preclinical studies have shown synergy between bortezomib and taxanes. We conducted a phase I study combining bortezomib and docetaxel in refractory solid tumor patients. Experimental Design: Patients received escalating doses of weekly docetaxel (days 1 and 8) and twice weekly bortezomib (days 2, 5, 9, and 12) in 3-week cycles. Two subjects were enrolled at each dose level, with cohort expansion to six for dose-limiting toxicity (DLT). Dose levels 1, 2, and 3 consisted of docetaxel/bortezomib 25/0.8, 25/1.0, and 30/1.0 mg/m super(2), respectively. CYP3A activity and docetaxel pharmacokinetic studies were conducted, and proteasome inhibition was assessed. RESULTS: Fourteen patients received a total of 34 cycles of treatment. Dose level 2 was expanded for DLT that occurred in two of six patients consisting of febrile neutropenia in one patient and grade 3 thrombocytopenia in one patient. One patient received two cycles at dose level 3 with dose reduction to dose level 2, where grade 3 thrombocytopenia occurred at cycle 3. Both episodes of grade 3 thrombocytopenia were transient (<7 days). Dose level 1 was then expanded to six patients where no DLTs occurred. CYP3A activity and docetaxel clearance did not change between weeks 1 and 5. CONCLUSIONS: The maximum tolerated dose was docetaxel 25 mg/m super(2) (days 1 and 8) with bortezomib 0.8 mg/m super(2) (days 2, 5, 9, and 12) given every 21 days. Bortezomib treatment did not alter CYP3A activity and docetaxel clearance. JF - Clinical Cancer Research AU - Messersmith, Wells A AU - Baker, Sharyn D AU - Lassiter, Lance AU - Sullivan, Rana A AU - Dinh, Kimberly AU - Almuete, Virna I AU - Wright, John J AU - Donehower, Ross C AU - Carducci, Michael A AU - Armstrong, Deborah K AD - Authors' Affiliations: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland and Cancer Therapeutics Evaluation Program, National Cancer Institute, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1270 EP - 1275 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 4 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts KW - Neutropenia KW - Thrombocytopenia KW - Solid tumors KW - Bortezomib KW - proteasomes KW - taxanes KW - Toxicity KW - Clinical trials KW - Pharmacokinetics KW - proteasome inhibitors KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21291234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Phase+I+Trial+of+Bortezomib+in+Combination+with+Docetaxel+in+Patients+with+Advanced+Solid+Tumors&rft.au=Messersmith%2C+Wells+A%3BBaker%2C+Sharyn+D%3BLassiter%2C+Lance%3BSullivan%2C+Rana+A%3BDinh%2C+Kimberly%3BAlmuete%2C+Virna+I%3BWright%2C+John+J%3BDonehower%2C+Ross+C%3BCarducci%2C+Michael+A%3BArmstrong%2C+Deborah+K&rft.aulast=Messersmith&rft.aufirst=Wells&rft.date=2006-02-01&rft.volume=12&rft.issue=4&rft.spage=1270&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neutropenia; Thrombocytopenia; Solid tumors; Bortezomib; proteasomes; taxanes; Toxicity; Clinical trials; proteasome inhibitors; Pharmacokinetics ER - TY - JOUR T1 - Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II study AN - 21272800; 6665221 AB - BACKGROUND: The aim of the study was to evaluate tolerance and efficacy of preoperative treatment with capecitabine in combination with radiation therapy (RT) in patients with locally advanced, resectable, rectal cancer. PATIENTS AND METHODS: Fifty-three patients with potentially resectable T3, N0-2 (87%) and T4, N0-2 (13%) rectal cancer were treated with capecitabine (825 mg/m super(2), twice daily for 7 days/week) and concomitant RT (50.4 Gy/28 fractions). Patients underwent surgery after 6-8 weeks followed, upon physician's indications, by 4-months adjuvant capecitabine. The primary end point was to determine the rate of pathologic complete response. Secondary end points were to assess the rate of clinical response and the safety profile. RESULTS: All patients but two completed the RT programme and 47 (89%) received 81%-100% of the capecitabine dose (100% of dose in 72% patients, 81%-95% in 17% patients and 48%-74% in 11% of patients). No patient had grade 4 toxicity. Grade 3 toxicity occurred in six patients (11%) and consisted mainly of leucopenia (4%) and hand-foot syndrome (4%). Mild or moderate toxicity was common and included leucopenia (72%), diarrhea (40%), proctitis (34%) and skin toxicity (20%). The overall clinical response rate was 58% and the downstaging rate was 57%, with a pathologic complete response rate of 24%. Among 34 patients with low-lying tumors (,5 cm from anal verge), 20 (59%) had a sphincter-saving operation. CONCLUSIONS: Preoperative chemoradiation with capecitabine and RT appeared to be effective in locally advanced resectable, rectal cancer. The favorable safety profile of the combination might warrant the use of capecitabine and RT with other effective new drugs. JF - Annals of Oncology AU - De Paoli, A AU - Chiara, S AU - Luppi, G AU - Friso, M L AU - Beretta, G D AU - Del Prete, S AU - Pasetto, L AU - Santantonio, M AU - Sarti, E AU - Mantello, G AU - Innocente, R AU - Frustaci, S AU - Corvo, R AU - Rosso, R AD - Departments of Radiation Oncology and Medical Oncology, C.R.O. - National Cancer Institute, Aviano Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 246 EP - 251 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 17 IS - 2 SN - 0923-7534, 0923-7534 KW - Toxicology Abstracts KW - Rectum KW - Skin KW - Diarrhea KW - Radiation KW - Surgery KW - Toxicity KW - Adjuvants KW - Tumors KW - Proctitis KW - Cancer KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21272800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=Capecitabine+in+combination+with+preoperative+radiation+therapy+in+locally+advanced%2C+resectable%2C+rectal+cancer%3A+a+multicentric+phase+II+study&rft.au=De+Paoli%2C+A%3BChiara%2C+S%3BLuppi%2C+G%3BFriso%2C+M+L%3BBeretta%2C+G+D%3BDel+Prete%2C+S%3BPasetto%2C+L%3BSantantonio%2C+M%3BSarti%2C+E%3BMantello%2C+G%3BInnocente%2C+R%3BFrustaci%2C+S%3BCorvo%2C+R%3BRosso%2C+R&rft.aulast=De+Paoli&rft.aufirst=A&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diarrhea; Skin; Rectum; Radiation; Surgery; Proctitis; Tumors; Adjuvants; Toxicity; Cancer ER - TY - JOUR T1 - Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride AN - 21063554; 8632107 AB - There is growing interest in using MRI to track cellular migration. To date, most work in this area has been performed using ultra-small particles of iron oxide. Immune cells are difficult to label with iron oxide particles. The ability of adoptively infused tumor specific T cells and N cells to traffic to the tumor microenvironment may be a critical determinant of their therapeutic efficacy. We tested the hypothesis that lymphocytes and B cells would label with MnCl2 to a level that would allow their detection by T1-weighted MRI. Significant signal enhancement was observed in human lymphocytes after a 1h incubation with 0.05-1.0mM MnCl2. A flow cytometry-based evaluation using propidium iodide and Annexin V staining showed that lymphocytes did not undergo apoptosis or necrosis immediately after and 24h following a 1h incubation with up to 1.0mM MnCl2. Importantly, NK cells and cytotoxic T cells maintained their in vitro killing capacity after being incubated with up to 0.5mM MnCl2. This is the first report to describe the use of MnCl2 to label lymphocytes. Our data suggests MnCl2 might be an alternative to iron oxide cell labeling for MRI-based cell migration studies. JF - NMR in Biomedicine AU - Aoki, Ichio AU - Takahashi, Yoshiyuki AU - Chuang, Kai-Hsiang AU - Silva, Afonso C AU - Igarashi, Takehito AU - Tanaka, Chuzo AU - Childs, Richard W AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1065, USA, korestskya@ninds.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 50 EP - 59 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 19 IS - 1 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Apoptosis KW - iron oxides KW - Lymphocytes B KW - propidium iodide KW - Magnetic resonance imaging KW - Natural killer cells KW - Chloride KW - Tumors KW - Leukocyte migration KW - Necrosis KW - Cytotoxicity KW - Lymphocytes T KW - Microenvironments KW - N.M.R. KW - Cell migration KW - Manganese KW - Annexin V KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Cell+labeling+for+magnetic+resonance+imaging+with+the+T1+agent+manganese+chloride&rft.au=Aoki%2C+Ichio%3BTakahashi%2C+Yoshiyuki%3BChuang%2C+Kai-Hsiang%3BSilva%2C+Afonso+C%3BIgarashi%2C+Takehito%3BTanaka%2C+Chuzo%3BChilds%2C+Richard+W%3BKoretsky%2C+Alan+P&rft.aulast=Aoki&rft.aufirst=Ichio&rft.date=2006-02-01&rft.volume=19&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - iron oxides; Magnetic resonance imaging; Leukocyte migration; Lymphocytes T; Tumors; Lymphocytes B; Cell migration; Apoptosis; Chloride; Natural killer cells; Annexin V; Manganese; N.M.R.; propidium iodide; Cytotoxicity; Microenvironments; Data processing; Necrosis DO - http://dx.doi.org/10.1002/nbm.1000 ER - TY - JOUR T1 - Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway AN - 20927347; 8338164 AB - The Plasmodium falciparum clone, Dd2, that requires sialic acid for invasion can switch to a sialic acid independent pathway, Dd2(NM). To elucidate the molecular basis of the switch in invasion phenotype of Dd2 to Dd2(NM), we performed expression profiling of the parasites using an oligonucleotide microarray and real-time RT-PCR. We found that four genes were upregulated in Dd2(NM) by microarray analysis, only two of which could be confirmed by real time RT-PCR. One gene, PfRH4, is a member of the reticulocyte homology family and the other, PEBL, is a pseudogene of the Duffy binding-like family. The two genes are contiguous but transcribed in opposite directions. The DNA sequence of these ORFs, their 5'-intergenic region and a 1.1 kb region 3'to each ORF are identical between Dd2 and Dd2(NM), suggesting that their transcription upregulation relates to transactivating factors. The transcription upregulation of PfRH4 was reflected at the protein level as PfRH4 protein expression was detected in Dd2(NM) and not in Dd2. Other sialic acid independent and dependent clones of P. falciparum showed variable transcript levels of PfRH4 and PEBL, unrelated to their dependence on sialic acid for invasion, suggesting that different P. falciparum clones use different receptors for sialic acid independent invasion. As Dd2(NM) is a selected subclone of Dd2, the marked upregulation of PfRH4 expression in Dd2(NM) suggests its role in erythrocyte invasion through the sialic acid independent pathway of Dd2(NM). JF - Molecular and Biochemical Parasitology AU - Gaur, Deepak AU - Furuya, Tetsuya AU - Mu, Jianbing AU - Jiang, Lu-bin AU - Su, Xin-zhuan AU - Miller, Louis H AD - Laboratory of Malaria and Vector Research (LMVR), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 12735 Twinbrook Parkway, Building Twinbrook III/Room 3E-32D, Bethesda, MD 20892-8132, USA, lmiller@niaid.nih.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 205 EP - 215 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 145 IS - 2 SN - 0166-6851, 0166-6851 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Plasmodium falciparum KW - Transcription KW - Erythrocyte invasion KW - Sialic Acids KW - Switch in invasion KW - Clones KW - Pseudogenes KW - Parasites KW - Nucleotide sequence KW - Erythrocytes KW - Profiling KW - Receptors KW - Genetic diversity KW - DNA microarrays KW - Oligonucleotides KW - Phenotypes KW - Gene expression KW - Population genetics KW - Homology KW - Polymerase chain reaction KW - Reticulocytes KW - Sialic acids KW - Open reading frames KW - N 14815:Nucleotide Sequence KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08521:Mechanical and natural changes KW - K 03310:Genetics & Taxonomy KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20927347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=Upregulation+of+expression+of+the+reticulocyte+homology+gene+4+in+the+Plasmodium+falciparum+clone+Dd2+is+associated+with+a+switch+in+the+erythrocyte+invasion+pathway&rft.au=Gaur%2C+Deepak%3BFuruya%2C+Tetsuya%3BMu%2C+Jianbing%3BJiang%2C+Lu-bin%3BSu%2C+Xin-zhuan%3BMiller%2C+Louis+H&rft.aulast=Abdullah&rft.aufirst=Sel%C3%A7uk&rft.date=2011-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Discrete+Dynamics+in+Nature+and+Society&rft.issn=10260226&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Clones; Population genetics; Parasites; Profiling; Erythrocytes; Receptors; Genetic diversity; Polymerase chain reaction; Phenotypes; Pseudogenes; Homology; Nucleotide sequence; Transcription; Oligonucleotides; Reticulocytes; DNA microarrays; Open reading frames; Sialic acids; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2005.10.004 ER - TY - JOUR T1 - 2004 Update of Dosimetry for the Utah Thyroid Cohort Study AN - 20860931; 6658390 AB - In the 1980s, individual thyroid doses and uncertainties were estimated for members of a cohort of children identified in 1965 in Utah and Nevada who had potentially been exposed to fallout from the Nevada Test Site. That reconstruction represented the first comprehensive assessment of doses received by the cohort and was the first large effort to assess the uncertainty of dose on an individual person basis. The data on dose and thyroid disease prevalence during different periods were subsequently used in an analysis to determine risks of radiogenic thyroid disease. This cohort has received periodic medical follow-up to observe changes in disease frequency and to reassess the previously reported radiation-related risks, most recently after a Congressional mandate in 1998. In a recent effort to restore the databases and computer codes used to estimate doses in the 1980s, various deficiencies were found in the estimated doses due to improperly operating computer codes, corruption of secondary data files, and lack of quality control procedures. From 2001 through 2004, the dosimetry system was restored and corrected and all doses were recalculated. In addition, two parameter values were updated. While the mean of all doses has not changed significantly, many individual doses have changed by more than an order of magnitude. JF - Radiation Research AU - Simon, S L AU - Anspaugh, L R AU - Hoffman, F O AU - Scholl, A E AU - Stone, M B AU - Thomas, BA AU - Lyon, J L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 208 EP - 222 PB - The Radiation Research Society VL - 165 IS - 2 SN - 0033-7587, 0033-7587 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Fallout KW - Databases KW - Data processing KW - Computers KW - Quality control KW - Dosimetry KW - thyroid diseases KW - Children KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=2004+Update+of+Dosimetry+for+the+Utah+Thyroid+Cohort+Study&rft.au=Simon%2C+S+L%3BAnspaugh%2C+L+R%3BHoffman%2C+F+O%3BScholl%2C+A+E%3BStone%2C+M+B%3BThomas%2C+BA%3BLyon%2C+J+L&rft.aulast=Simon&rft.aufirst=S&rft.date=2006-02-01&rft.volume=165&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282006%291652.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=165&issue=2&page=208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fallout; Databases; Data processing; Quality control; Computers; Dosimetry; thyroid diseases; Children DO - http://dx.doi.org/10.1043/0033-7587(2006)165[208:UODFTU]2.0.CO;2 ER - TY - JOUR T1 - Duration of rheumatoid arthritis influences the degree of functional improvement in clinical trials AN - 20860130; 6659964 AB - BACKGROUND: Functional capacity is an important outcome in rheumatoid arthritis and is generally measured using the Health Assessment Questionnaire disability index (HAQ). Functional limitation incorporates both activity and damage. Because irreversible damage increases over time, the HAQ may be less likely to show improvement in late than in early rheumatoid arthritis. OBJECTIVE: To determine the relation between sensitivity to change of the HAQ and duration of rheumatoid arthritis in reports of clinical trials. METHODS: Data were pooled from clinical trials that measured responses of HAQ scores at three or six months. The effect size of the HAQ was calculated and linear regression used to predict the effect size by duration of rheumatoid arthritis at group level. Treatment effect was adjusted for by including the effect sizes of pain scores and of tender joint counts as additional independent variables in separate models. Subgroup analysis employed contemporary regimens (methotrexate, leflunomide, combination therapies, and TNF inhibitors) only. RESULTS: 36 studies with 64 active treatment arms and 7628 patients (disease duration 2.5 months to 12.2 years) were included. The effect sizes of the HAQ decreased by 0.02 for each additional year of mean disease duration using all trials, and by 0.04/year in the subgroup analysis (p[les]0.01 for both analyses, except for pain adjusted models at three months). CONCLUSIONS: In individual trials, less improvement in the HAQ might be expected in late than in early rheumatoid arthritis. Comparison of changes in HAQ among rheumatoid arthritis trials should take into consideration the disease stage of the treated groups. JF - Annals of the Rheumatic Diseases AU - Aletaha, D AU - Ward, M M AD - Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 227 EP - 233 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 2 SN - 0003-4967, 0003-4967 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Inventories KW - Rheumatoid arthritis KW - Data processing KW - Tumor necrosis factor KW - Joint diseases KW - Methotrexate KW - Pain KW - Clinical trials KW - leflunomide KW - Models KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+Rheumatic+Diseases&rft.atitle=Duration+of+rheumatoid+arthritis+influences+the+degree+of+functional+improvement+in+clinical+trials&rft.au=Aletaha%2C+D%3BWard%2C+M+M&rft.aulast=Aletaha&rft.aufirst=D&rft.date=2006-02-01&rft.volume=65&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+Rheumatic+Diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Rheumatoid arthritis; Data processing; Tumor necrosis factor; Joint diseases; Methotrexate; Pain; Clinical trials; leflunomide; Models ER - TY - JOUR T1 - Dual-echo spiral in/in acquisition method for reducing magnetic susceptibility artifacts in blood-oxygen-level-dependent functional magnetic resonance imaging AN - 20859776; 8368030 AB - MRI signal dropout in gradient recalled echo acquisitions limits the capability of blood-oxygen-level-dependent functional magnetic resonance imaging (fMRI) to study activation tasks that involve the orbitofrontal, temporal, and basal areas of the brain where significant macroscopic magnetic susceptibility differences exist. Among the various approaches aimed to address this issue, the acquisition method based on spiral in/out trajectories is one of the most time-efficient and effective techniques. In this study, we extended further the spiral in/out approach into 3D acquisition and compared the effectiveness of the different spiral in/out trajectory combinations in reducing signal dropout. The activation results from whole brain fMRI studies using complex finger tapping and breath-holding tasks demonstrate that the acquisition method based on dual-echo spiral in/in (DSPIN) trajectories is the most favorable. The DSPIN acquisition method has the following advantages: (1) It reduces most effectively signal dropout in the brain where magnetic susceptibility inhomogeneity is problematic and significantly improves the sensitivity to detect functional activations in those regions. (2) It significantly improves SNR in the whole brain by dual echo averaging without compromising functional contrast. (3) There is no reduction in time-efficiency and spatial resolution. JF - Magnetic Resonance in Medicine AU - Li, Tie-Qiang AU - Takahashi, Atsushi AU - Wang, Yang AU - Mathews, Vincent AU - Glover, Gary H AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disease and Stroke, Nation Institutes of Health, Bethesda, Maryland, USA, litie@ninds.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 325 EP - 334 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Functional magnetic resonance imaging KW - Motor task performance KW - Magnetic resonance imaging KW - Magnetic susceptibility KW - spatial discrimination KW - Finger KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Dual-echo+spiral+in%2Fin+acquisition+method+for+reducing+magnetic+susceptibility+artifacts+in+blood-oxygen-level-dependent+functional+magnetic+resonance+imaging&rft.au=Li%2C+Tie-Qiang%3BTakahashi%2C+Atsushi%3BWang%2C+Yang%3BMathews%2C+Vincent%3BGlover%2C+Gary+H&rft.aulast=Li&rft.aufirst=Tie-Qiang&rft.date=2006-02-01&rft.volume=55&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20783 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Brain mapping; Magnetic susceptibility; Magnetic resonance imaging; Finger; Motor task performance; spatial discrimination DO - http://dx.doi.org/10.1002/mrm.20783 ER - TY - JOUR T1 - In vivo detection of single cells by MRI AN - 20859755; 8368019 AB - The use of high-relaxivity, intracellular contrast agents has enabled MRI monitoring of cell migration through and homing to various tissues, such as brain, spinal cord, heart, and muscle. Here it is shown that MRI can detect single cells in vivo, homing to tissue, following cell labeling and transplantation. Primary mouse hepatocytes were double-labeled with green fluorescent 1.63-m iron oxide particles and red fluorescent endosomal labeling dye, and injected into the spleens of recipient mice. This is a common hepatocyte transplantation paradigm in rodents whereby hepatocytes migrate from the spleen to the liver as single cells. One month later the animals underwent in vivo MRI and punctuated, dark contrast regions were detected scattered through the livers. MRI of perfused, fixed samples and labeled hepatocyte phantoms in combination with histological evaluation confirmed the presence of dispersed single hepatocytes grafted into the livers. Appropriate controls were used to determine whether the observed contrast could have been due to dead cells or free particles, and the results confirmed that the contrast was due to disperse, single cells. Detecting single cells in vivo opens the door to a number of experiments, such as monitoring rare cellular events, assessing the kinetics of stem cell homing, and achieving early detection of metastases. JF - Magnetic Resonance in Medicine AU - Shapiro, Erik M AU - Sharer, Kathryn AU - Skrtic, Stanko AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, ShapiroE@ninds.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 242 EP - 249 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - iron oxides KW - Spinal cord KW - Hepatocytes KW - Magnetic resonance imaging KW - Brain KW - Muscles KW - Cardiac muscle KW - Spleen KW - Metastases KW - Stem cells KW - Kinetics KW - Allografts KW - Contrast media KW - Liver KW - N.M.R. KW - Cell migration KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amidwestnews1&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Dayton+Daily+News&rft.atitle=MILWAUKEE+AB+R+H+BI+BB+SO+AVG.+LORETTA+2B+4+0+0+0+0+1+.309+BURNITZ+RF+4+1+1+1+0+0+.281+CIRILLO+3B+4+0+1+0+0+1+.299+NILSSON+1B+3+1+1+0+1+2+.272+JSVALENTIN+SS+4+0+1+0+0+1+.267+GEWILLIAMS+CF+4+1+1+0+0+0+.270+VOIGT+LF+2+1+1+1+0+1+.318+MATHENY+C+1+0+0+1+0+0+.231+D-LEVIS+PH-C+2+0+0+0+0+0+.256+BMCDONALD+P+1+0+0+0+0+1+.000+WILLIAMSON+PH+1+0+0+1+0+0+.220+ADAMSON+P+0+0+0+0+0+0+FETTERS+P+0+0+0+0+0+0+HUSON+PH+1+0+0+0+0+1+.240+VILLONE+P+0+0+0+0+0+0+WICKMAN+P+0+0+0+0+0+0+TOTALS+31+4+6+4+1+8%3A+%5BCITY+EDITION%5D&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1997-07-03&rft.volume=&rft.issue=&rft.spage=3.C&rft.isbn=&rft.btitle=&rft.title=Dayton+Daily+News&rft.issn=08970920&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hepatocytes; Cell migration; Magnetic resonance imaging; Liver; Allografts; Spleen; Stem cells; Spinal cord; Muscles; Brain; N.M.R.; Cardiac muscle; Kinetics; Contrast media; Metastases; iron oxides DO - http://dx.doi.org/10.1002/mrm.20718 ER - TY - JOUR T1 - Estrogens and Glucocorticoids Have Opposing Effects on the Amount and Latent Activity of Complement Proteins in the Rat Uterus AN - 20859139; 6658297 AB - The mammalian uterus faces unique immunological challenges. It must nurture and protect the semiallogenic fetus from attack by the maternal immune system while guarding against infection by pathogens that compromise fetal and maternal health. Complement has recently been implicated in the etiology of pregnancy loss, but its regulation by steroid hormones and its role in host defense in the uterus are not clearly defined. Here we use biochemical, functional, and physiological assays to elucidate the regulation of complement proteins in the rat uterus. We demonstrate that estrogens (17 beta-estradiol) and glucocorticoids (dexamethasone) have major, but opposing, effects on the amount and latent activity of complement effectors in the uterus. Treatment with 17 beta-estradiol induced vasodilation and an increase in vascular permeability, which resulted in extravasation of plasma and complement into the uterus, rather than de novo complement biosynthesis. In vitro assays revealed that 17 beta-estradiol induced a potent bactericidal activity in uterine luminal fluid and that the antibacterial component was complement. These proinflammatory and immunomodulatory effects were evident within 4 h of treatment and were blocked by coadministration of dexamethasone. We also found that estrogen effects on the vasculature were mediated in part by activation of the contact system and bradykinin B1 receptors. These results indicate that complement plays a central role in innate immunity in the female reproductive tract and suggest that estrogens or glucocorticoids might be used therapeutically to enhance or inhibit complement-dependent processes in the uterus. JF - Biology of Reproduction AU - Rhen, T AU - Cidlowski, JA AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 265 EP - 274 PB - Society for the Study of Reproduction VL - 74 IS - 2 SN - 0006-3363, 0006-3363 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Dexamethasone KW - Etiology KW - Estrogens KW - Uterus KW - Immune system KW - Abortion KW - Bradykinin B1 receptors KW - Immunity KW - Steroid hormones KW - Pathogens KW - Infection KW - Extravasation KW - Glucocorticoids KW - Fetuses KW - Inflammation KW - Permeability KW - Vasodilation KW - Bactericidal activity KW - Vascular system KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+Reproduction&rft.atitle=Estrogens+and+Glucocorticoids+Have+Opposing+Effects+on+the+Amount+and+Latent+Activity+of+Complement+Proteins+in+the+Rat+Uterus&rft.au=Rhen%2C+T%3BCidlowski%2C+JA&rft.aulast=Rhen&rft.aufirst=T&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Biology+of+Reproduction&rft.issn=00063363&rft_id=info:doi/10.1095%2Fbiolreprod.105.045336 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0006-3363&volume=74&issue=2&page=265 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Uterus; Estrogens; Etiology; Abortion; Immune system; Bradykinin B1 receptors; Pathogens; Steroid hormones; Immunity; Infection; Glucocorticoids; Extravasation; Fetuses; Inflammation; Permeability; Vasodilation; Bactericidal activity; Vascular system DO - http://dx.doi.org/10.1095/biolreprod.105.045336 ER - TY - JOUR T1 - BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system AN - 20856890; 8368029 AB - A multislice spin echo EPI sequence was used to obtain functional MR images of the entire rat brain with blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) contrast at 11.7 T. Maps of activation incidence were created by warping each image to the Paxinos rat brain atlas and marking the extent of the activated area. Incidence maps for BOLD and CBV were similar, but activation in draining veins was more prominent in the BOLD images than in the CBV images. Cerebellar activation was observed along the surface in BOLD images, but in deeper regions in the CBV images. Both effects may be explained by increased signal dropout and distortion in the EPI images after administration of the ferumoxtran-10 contrast agent for CBV fMRI. CBV-weighted incidence maps were also created for 10, 20, and 30 mg Fe/kg doses of ferumoxtran-10. The magnitude of the average percentage change during stimulation increased from 4.9% with the 10 mg Fe/kg dose to 8.7% with the 30-mg Fe/kg dose. Incidence of activation followed a similar trend. JF - Magnetic Resonance in Medicine AU - Keilholz, Shella D AU - Silva, Afonso C AU - Raman, Mira AU - Merkle, Hellmut AU - Koretsky, Alan P AD - Emory University, Atlanta, Georgia, USA, KoretskyA@ninds.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 316 EP - 324 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Functional magnetic resonance imaging KW - Cerebellum KW - Veins KW - Atlases KW - Somatosensory system KW - Contrast media KW - N.M.R. KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=BOLD+and+CBV-weighted+functional+magnetic+resonance+imaging+of+the+rat+somatosensory+system&rft.au=Keilholz%2C+Shella+D%3BSilva%2C+Afonso+C%3BRaman%2C+Mira%3BMerkle%2C+Hellmut%3BKoretsky%2C+Alan+P&rft.aulast=Keilholz&rft.aufirst=Shella&rft.date=2006-02-01&rft.volume=55&rft.issue=2&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20744 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain mapping; Functional magnetic resonance imaging; Atlases; N.M.R.; Cerebral blood flow; Contrast media; Cerebellum; Veins; Somatosensory system DO - http://dx.doi.org/10.1002/mrm.20744 ER - TY - JOUR T1 - Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland) AN - 20722560; 7015380 AB - Helicobacter pylori infection is an important risk factor for gastric cancer, but <3% of carriers of this organism will ever develop gastric cancer. Since inflammation plays a significant role in gastric carcinogenesis, it has been suggested that polymorphisms in genes involved in inflammatory response may partly explain why only a subgroup of patients infected with H. pylori develop gastric cancer. We compared relative frequencies of 17 single nucleotide polymorphisms (SNPs) in eight inflammation-related genes between 112 gastric cancer patients and 208 controls. Cases and controls were selected from a large cohort of Finnish male smokers who were recruited into the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. The studied SNPs were IL-1A (-889 C/T), IL-1B (-511 C/T and -31 T/C), IL-6 (-174 G/C and -597 G/A), IL-8 (-251 T/A, +396 T/G and +781 C/T), IL-8RA (Ex2 +860 G/C), IL-8RB (Exon 3 +1235 T/C, Exon 3 +811 C/T, and Exon 3 +1010 G/A), IL-10 (-819 C/T, -592 C/A, -1082 A/G), and TNF A (-308 G/A, -238 G/A). We found no statistically significant association between any of these SNPs, or the number of pro-inflammatory polymorphisms, with risk of gastric cancer. Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals. JF - Cancer Causes & Control AU - Kamangar, Farin AU - Abnet, Christian C AU - Hutchinson, Amy A AU - Newschaffer, Craig J AU - Helzlsouer, Kathy AU - Shugart, Yin Yao AU - Pietinen, Pirjo AU - Dawsey, Sanford M AU - Albanes, Demetrius AU - Virtamo, Jarmo AU - Taylor, Philip R AD - US National Cancer Institute, Bethesda, MD, 20892-7232, USA, kamangaf@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 117 EP - 125 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 1 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Interleukin 6 KW - Helicobacter pylori KW - Finland KW - Exons KW - Gene polymorphism KW - Tumor necrosis factor KW - Interleukin 1 KW - Statistical analysis KW - Infection KW - Cancer KW - Interleukin 10 KW - Interleukin 8 KW - Inflammation KW - Single-nucleotide polymorphism KW - Risk factors KW - Carcinogenesis KW - infection KW - prevention KW - Gastric cancer KW - R2 23060:Medical and environmental health KW - J 02350:Immunology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Polymorphisms+in+Inflammation-related+Genes+and+Risk+of+Gastric+Cancer+%28Finland%29&rft.au=Kamangar%2C+Farin%3BAbnet%2C+Christian+C%3BHutchinson%2C+Amy+A%3BNewschaffer%2C+Craig+J%3BHelzlsouer%2C+Kathy%3BShugart%2C+Yin+Yao%3BPietinen%2C+Pirjo%3BDawsey%2C+Sanford+M%3BAlbanes%2C+Demetrius%3BVirtamo%2C+Jarmo%3BTaylor%2C+Philip+R&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2006-02-01&rft.volume=17&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-005-0439-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Exons; Tumor necrosis factor; Gene polymorphism; Interleukin 1; Statistical analysis; Infection; Interleukin 8; Interleukin 10; Inflammation; Single-nucleotide polymorphism; Risk factors; Carcinogenesis; Gastric cancer; prevention; infection; Cancer; Helicobacter pylori; Finland DO - http://dx.doi.org/10.1007/s10552-005-0439-7 ER - TY - JOUR T1 - Genetic Variation in the Sodium-dependent Vitamin C Transporters, SLC23A1, and SLC23A2 and Risk for Preterm Delivery AN - 20719123; 6659837 AB - Vitamin C has been the focus of epidemiologic investigation in preterm delivery (<37 weeks' gestation), which is a leading cause of neonatal mortality and birth-related morbidity. There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, which have key roles in human vitamin C metabolism and which control dietary uptake, reabsorption, and tissue distribution of vitamin C. Using maternal DNA, the authors evaluated common single-nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2 in a nested case-control analysis of the Pregnancy, Infection, and Nutrition Study (1995-2000) cohort. Of the associations observed for both haplotypes in SLC23A1 and individual SNPs in SLC23A2, the most robust finding is with an intron 2 variant in SLC23A2. Heterozygotes and homozygotes for this variant had a 1.7-fold (95% confidence interval: 0.9, 3.3) and a 2.7-fold (95% confidence interval: 1.2, 6.3) elevation in the risk of spontaneous preterm birth, respectively. Semi-Bayesian hierarchical regression analysis, which simultaneously adjusted for multiple SNPs within the same gene, gave comparable results. The authors' findings link genetic variants in the vitamin C transporters to spontaneous preterm birth, which may explain previous dietary associations. If the findings from this study are confirmed, they may serve as the foundation for genetic risk assessment of nutritional pathways in preterm birth. JF - American Journal of Epidemiology AU - Erichsen, Hans Christian AU - Engel, Stephanie AMulherin AU - Eck, Peter K AU - Welch, Robert AU - Yeager, Meredith AU - Levine, Mark AU - Siega-Riz, Anna Maria AU - Olshan, Andrew F AU - Chanock, Stephen J AD - Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 245 EP - 254 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 163 IS - 3 SN - 0002-9262, 0002-9262 KW - Genetics Abstracts; Risk Abstracts KW - Risk assessment KW - Genetic diversity KW - Infection KW - Nutrition KW - Homozygotes KW - Morbidity KW - foundations KW - vitamins KW - Haplotypes KW - introns KW - Gestation KW - infection KW - Regression analysis KW - Reabsorption KW - Diets KW - Mortality KW - Membranes KW - genetic diversity KW - haplotypes KW - Pregnancy KW - Ascorbic acid KW - Birth KW - Single-nucleotide polymorphism KW - Heterozygotes KW - Introns KW - DNA KW - Neonates KW - Metabolism KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20719123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Genetic+Variation+in+the+Sodium-dependent+Vitamin+C+Transporters%2C+SLC23A1%2C+and+SLC23A2+and+Risk+for+Preterm+Delivery&rft.au=Erichsen%2C+Hans+Christian%3BEngel%2C+Stephanie+AMulherin%3BEck%2C+Peter+K%3BWelch%2C+Robert%3BYeager%2C+Meredith%3BLevine%2C+Mark%3BSiega-Riz%2C+Anna+Maria%3BOlshan%2C+Andrew+F%3BChanock%2C+Stephen+J&rft.aulast=Erichsen&rft.aufirst=Hans&rft.date=2006-02-01&rft.volume=163&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Genetic diversity; Infection; Nutrition; Morbidity; Homozygotes; Ascorbic acid; Pregnancy; Birth; Haplotypes; Single-nucleotide polymorphism; Gestation; Heterozygotes; DNA; Introns; Regression analysis; Neonates; Metabolism; Reabsorption; Diets; Membranes; genetic diversity; haplotypes; foundations; vitamins; introns; infection ER - TY - JOUR T1 - How Much is Enough? Modulation of Dose-Response Curve for Steroid Receptor-Regulated Gene Expression by Changing Concentrations of Transcription Factor AN - 20639730; 7658333 AB - The position of the dose-response curve for steroid-regulated gene expression determines how much variation in response will accompany the normal physiological changes in circulating steroid. Over the last several years, it has become clear that the concentration of steroid hormone required for half-maximal induction or repression by a given receptor-steroid complex, which is normally called the EC50, is not constant for all responsive genes. Thus, the position of the dose-response curve can change so that a single concentration of steroid produces very different percentages of maximal activity. This, in turn, allows for the differential expression of genes by a common steroid hormone concentration during development, differentiation, and homeostasis. Here we review the variety of factors that influence the EC50 and position of the dose-response curve for steroid hormone receptors, discuss what is known about the mechanisms, and highlight promising areas for future research. JF - Current Topics in Medicinal Chemistry AU - Simons Jr, SS AD - Bldg. 10, Room 8N307B, NIDDK/CEB, NIH, Bethesda, MD 20892-1772. Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 271 EP - 285 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 6 IS - 3 SN - 1568-0266, 1568-0266 KW - Genetics Abstracts; Biotechnology Research Abstracts (through 1992) KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=How+Much+is+Enough%3F+Modulation+of+Dose-Response+Curve+for+Steroid+Receptor-Regulated+Gene+Expression+by+Changing+Concentrations+of+Transcription+Factor&rft.au=Simons+Jr%2C+SS&rft.aulast=Simons+Jr&rft.aufirst=SS&rft.date=2006-02-01&rft.volume=6&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Thyrotropin-Releasing Hormone Analogs AN - 20638218; 7659867 AB - Thyrotropin releasing hormone (TRH: pyroglutamic acid-histidine- prolineamide) regulates the activity of cells in the anterior pituitary and within the central and peripheral nervous systems. TRH, which has been the subject of much research over the past three decades, exerts its effects by acting through class A G-protein coupled receptors. The recent discovery of a second receptor subtype has generated an interest in the discovery of receptor subtype-selective TRH analogs. In this review, we describe advances in the development of TRH analogs and in the understanding of their mechanism of interaction with TRH receptors. We also describe the recent breakthrough in the identification of analogs that bind selectively at TRH-R2. JF - Mini-Reviews in Medicinal Chemistry AU - Colson, A O AU - Gershengorn, M C AD - Clinical Endocrinology Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bldg 50/4134, Bethesda, MD 20892; USA. Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 221 EP - 226 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 6 IS - 2 SN - 1389-5575, 1389-5575 KW - Biotechnology and Bioengineering Abstracts KW - TRH KW - TRH receptor KW - hormone KW - neuropeptide KW - analogs KW - Thyrotropin-releasing hormone KW - double prime G protein-coupled receptors KW - Reviews KW - Peripheral nervous system KW - Thyroid-stimulating hormone KW - Pituitary (anterior) KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20638218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mini-Reviews+in+Medicinal+Chemistry&rft.atitle=Thyrotropin-Releasing+Hormone+Analogs&rft.au=Colson%2C+A+O%3BGershengorn%2C+M+C&rft.aulast=Colson&rft.aufirst=A&rft.date=2006-02-01&rft.volume=6&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Mini-Reviews+in+Medicinal+Chemistry&rft.issn=13895575&rft_id=info:doi/10.2174%2F138955706775476019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Thyrotropin-releasing hormone; double prime G protein-coupled receptors; Reviews; Peripheral nervous system; Thyroid-stimulating hormone; Pituitary (anterior) DO - http://dx.doi.org/10.2174/138955706775476019 ER - TY - JOUR T1 - Comparison of Drug Transporter Levels in Normal Colon, Colon Cancer, and Caco-2 Cells: Impact on Drug Disposition and Discovery AN - 20423772; 7829679 AB - A critical step in early phase drug development is the determination of oral bioavailability. In part, the ability to predict whether a drug will be effectively transported across the gastrointestinal mucosa can be estimated from the physicochemical properties of the compound. Although advancements through rational drug design have more correctly predicted bioavailability, considerable variability remains to be explained. Transporter expression throughout the gastrointestinal tract may explain much of this variation. ATP-binding cassette (ABC) transporters were the first family of transporters identified to modify bioavailability. More recently, the solute carrier family has also been shown to alter the pharmacokinetic profile of drugs. Currently, the Caco-2 human colon carcinoma cell line is often used by the pharmaceutical industry to evaluate intestinal absorption of drugs; however, in vivo/in vitro permeabilities with carrier mediated drugs do not correlate well, suggesting that Caco-2 transporter expression varies from that of the small intestine. With this is mind, we integrated U133A GeneChip expression data from the NCBIs Gene Expression Omnibus (GEO) collection and then compared the expression pattern of Caco-2 cells to normal colon to determine if the Caco-2 cell line is a reliable model for colonic delivery. Furthermore, transporter expression of Caco-2 cells was compared to that of human colon tumors to assess whether this cell line could be useful to predict drug absorption for colon cancer. Our analysis shows that the expression pattern for Caco-2 cells closely resembles the gene expression profile of transporters within the normal colon, suggesting that this cell line may serve as an in vitro model of colonic drug adsorption. However, the molecular "fingerprint" of Caco-2 was distinctly different from tumor samples, indicating that the Caco-2 model would unlikely predict accurate drug absorption for colon cancer sites. JF - Molecular Pharmaceutics AU - Calcagno, A M AU - Ludwig, JA AU - Fostel, J M AU - Gottesman, M M AU - Ambudkar, S V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 87 EP - 93 VL - 3 IS - 1 SN - 1543-8384, 1543-8384 KW - Biotechnology Research Abstracts (through 1992) KW - Intestinal absorption KW - Molecular modelling KW - ABC transporter KW - Mucosa KW - Physicochemical properties KW - Disposition KW - Small intestine KW - Drug development KW - Tumors KW - Colon cancer KW - Pharmacokinetics KW - Gene expression KW - Drug discovery KW - Solutes KW - Permeability KW - Tumor cell lines KW - Adsorption KW - Pharmaceuticals KW - Gastrointestinal tract KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20423772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Comparison+of+Drug+Transporter+Levels+in+Normal+Colon%2C+Colon+Cancer%2C+and+Caco-2+Cells%3A+Impact+on+Drug+Disposition+and+Discovery&rft.au=Calcagno%2C+A+M%3BLudwig%2C+JA%3BFostel%2C+J+M%3BGottesman%2C+M+M%3BAmbudkar%2C+S+V&rft.aulast=Calcagno&rft.aufirst=A&rft.date=2006-02-01&rft.volume=3&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp050090k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gene expression; Drug development; Colon cancer; Tumors; Small intestine; Tumor cell lines; Permeability; Physicochemical properties; Solutes; Pharmaceuticals; Disposition; Drug discovery; Mucosa; Pharmacokinetics; Intestinal absorption; Gastrointestinal tract; Adsorption; Molecular modelling; ABC transporter DO - http://dx.doi.org/10.1021/mp050090k ER - TY - JOUR T1 - The association between neurological deficit in acute ischemic stroke and mean transit time Comparison of four different perfusion MRI algorithms AN - 20231049; 6852922 AB - The purpose of our study was to identify the perfusion MRI (pMRI) algorithm which yields a volume of hypoperfused tissue that best correlates with the acute clinical deficit as quantified by the NIH Stroke Scale (NIHSS) and therefore reflects critically hypoperfused tissue. A group of 20 patients with a first acute stroke and stroke MRI within 24 h of symptom onset were retrospectively analyzed. Perfusion maps were derived using four different algorithms to estimate relative mean transit time (rMTT): (1) cerebral blood flow (CBF) arterial input function (AIF)/singular voxel decomposition (SVD); (2) area peak; (3) time to peak (TTP); and (4) first moment method. Lesion volumes based on five different MTT thresholds relative to contralateral brain were compared with each other and correlated with NIHSS score. The first moment method had the highest correlation with NIHSS (r=0.79, P<0.001) followed by the AIF/SVD method, both of which did not differ significantly from each other with regard to lesion volumes. TTP and area peak derived both volumes, which correlated poorly or only moderately with NIHSS scores. Data from our pilot study suggest that the first moment and the AIF/SVD method have advantages over the other algorithms in identifying the pMRI lesion volume that best reflects clinical severity. At present there seems to be no need for extensive postprocessing and arbitrarily defined delay thresholds in pMRI as the simple qualitative approach with a first moment algorithm is equally accurate. Larger sample sizes which allow comparison between imaging and clinical outcomes are needed to refine the choice of best perfusion parameter in pMRI. JF - Neuroradiology AU - Schellinger, P D AU - Latour, L L AU - Wu, C-S AU - Chalela, JA AU - Warach, S AD - Section on Stroke Diagnostics and Therapeutics, NINDS, NIH, Bethesda, MA 20892, USA, Peter_Schellinger@med.uni-heidelberg.de Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 69 EP - 77 VL - 48 IS - 2 SN - 0028-3940, 0028-3940 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Perfusion KW - Magnetic resonance imaging KW - Stroke KW - Brain KW - Algorithms KW - Ischemia KW - Maps KW - Decomposition KW - Apoptosis-inducing factor KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20231049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=MENA+Report&rft.atitle=Terracing+At+Tale+1%2F1+To+1%2F2+At+Ghera+1%2F1+To+1%2F5+Ropb+At+Khopi+1%2F1+To+1%2F6+And+Tale+1%2F1+To+1%2F3+Tal-khed+%5BTender+documents+%3A+T37102960%5D&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2016-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=MENA+Report&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Algorithms; Stroke; Perfusion; Magnetic resonance imaging; Apoptosis-inducing factor; Cerebral blood flow; Maps; Neuroimaging; Brain; Ischemia; Decomposition DO - http://dx.doi.org/10.1007/s00234-005-0012-9 ER - TY - JOUR T1 - Diagnosis/Therapy in Ophthalmology: Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma AN - 20227094; 6630925 AB - Purpose:To describe a case with motile cyst in the anterior chamber in the right eye of a 7-year-old boy. Methods:The right eye's visual acuity was 20-50. Intraocular pressure was 59 mmHg. Slit-lamp examination showed prominent rubeosis iridis and a grey-white mass floating freely in the anterior chamber. Ultrasound biomicroscopy revealed a cystic mass in the anterior chamber. A diagnostic cyclectomy with removal of the anterior chamber cyst was performed. Histopathology of the anterior chamber lesion showed an intact cyst composed of medullary epithelial cells. Medulloepithelioma with malignant criteria was diagnosed and the eye was enucleated. Results:Pathology demonstrated an medulloepithelioma with a few mitotic figures and nuclear pleomorphisms within the ciliary body. The patient was followed for 8 months without any metastasis in the orbit or elsewhere. Conclusion:Intraocular medulloepithelioma is a rare embryonic benign or malignant neoplasm typically diagnosed in the first decade of life as a ciliary body mass. A dislodged, free-floating anterior chamber cyst associated with neovascular glaucoma is typical of medulloepithelioma in children. This unique presentation should be differentiated from congenital iris epithelial, post-traumatic, epithelial, parasitic and neoplastic cysts. Ultrasound biomicroscopy is useful for analysing the structure of the anterior segment mass. Ciliary body medulloepithelioma is characterized by echogenic mass heterogeneity and an irregular surface containing multiple cystic cavities. Lack of glial differentiation may predict a better clinical outcome in primary neuroectodermal brain tumours. JF - Acta Ophthalmologica Scandinavica AU - Zhou, Min AU - Xu, Gezhi AU - Bojanowski, Christine M AU - Song, Yuelian AU - Chen, Rongjia AU - Sun, Xinhuai AU - Wang, Weiji AU - Chan, Chi-Chao AD - Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA, chanc@nei.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 137 EP - 139 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 84 IS - 1 SN - 1395-3907, 1395-3907 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Cavities KW - Eye KW - Anterior chamber KW - Body mass KW - Acuity KW - Iris KW - Children KW - Cysts KW - Brain tumors KW - Metastases KW - Differentiation KW - Differential diagnosis KW - Glaucoma KW - Embryos KW - Pressure KW - Neuronal-glial interactions KW - Ultrasound KW - Pleomorphism KW - Benign KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Ophthalmologica+Scandinavica&rft.atitle=Diagnosis%2FTherapy+in+Ophthalmology%3A+Differential+diagnosis+of+anterior+chamber+cysts+with+ultrasound+biomicroscopy%3A+ciliary+body+medulloepithelioma&rft.au=Zhou%2C+Min%3BXu%2C+Gezhi%3BBojanowski%2C+Christine+M%3BSong%2C+Yuelian%3BChen%2C+Rongjia%3BSun%2C+Xinhuai%3BWang%2C+Weiji%3BChan%2C+Chi-Chao&rft.aulast=Zhou&rft.aufirst=Min&rft.date=2006-02-01&rft.volume=84&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Acta+Ophthalmologica+Scandinavica&rft.issn=13953907&rft_id=info:doi/10.1111%2Fj.1600-0420.2005.00542.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - SuppNotes - Figures, 4; references, 5. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cavities; Epithelial cells; Eye; Anterior chamber; Body mass; Acuity; Iris; Cysts; Children; Metastases; Brain tumors; Differentiation; Differential diagnosis; Glaucoma; Embryos; Neuronal-glial interactions; Pressure; Pleomorphism; Ultrasound; Benign DO - http://dx.doi.org/10.1111/j.1600-0420.2005.00542.x ER - TY - JOUR T1 - Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts AN - 20222598; 6713883 AB - Tumor necrosis factor (TNF) plays an important role in the pathogenesis of inflammatory bone loss through stimulation of osteoclastic bone resorption and inhibition of osteoblastic bone formation. Compared with the well established role of TNF in osteoclastogenesis, mechanisms by which TNF inhibits osteoblast function have not been fully determined. Runx2 is an osteoblast-specific transcription factor whose steady-state protein levels are regulated by proteasomal degradation, mediated by the E3 ubiquitin ligases, Smurf1 and Smurf2. We hypothesized that TNF inhibits osteoblast function through Smurf-mediated Runx2 degradation. We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that TNF, but not interleukin-1, significantly increased Smurf1 and Smurf2 expression. TNF increased the degradation of endogenous or transfected Runx2 protein, which was blocked by treating cells with a proteasomal inhibitor or by infecting cells with small interfering (si)RNA against Smurf1 or Smurf2. TNF inhibited the expression of bone morphogenetic protein and transforming growth factor- beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively. Overexpression of Smurf1 and/or Smurf2 siRNAs prevented the inhibitory effect of TNF on Runx2 reporter. Consistent with these in vitro findings, bones from TNF transgenic mice or TNF-injected wild type mice had increased Smurf1 and decreased Runx2 protein levels. We propose that one of the mechanisms by which TNF inhibits bone formation in inflammatory bone disorders is by promoting Runx2 proteasomal degradation through up-regulation of Smurf1 and Smurf2 expression. JF - Journal of Biological Chemistry AU - Kaneki, Hiroyuki AU - Guo, Ruolin AU - Chen, Di AU - Yao, Zhenqiang AU - Schwarz, Edward M AU - Zhang, Ying E AU - Boyce, Brendan F AU - Xing, Lianping AD - Department of Pathology and Laboratory Medicine and Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, and the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 4326 EP - 4333 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 7 SN - 0021-9258, 0021-9258 KW - Smurf1 protein KW - Smurf2 protein KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Calcium & Calcified Tissue Abstracts KW - Osteoclasts KW - Cbfa-1 protein KW - Tumor necrosis factor KW - Interleukin 1 KW - proteasomes KW - Transgenic mice KW - Ubiquitin-protein ligase KW - Inflammation KW - Osteoblasts KW - Bone morphogenetic proteins KW - Glial stem cells KW - siRNA KW - Inflammatory diseases KW - Transcription factors KW - Transforming growth factor- beta KW - Bone loss KW - Osteoprogenitor cells KW - Bone diseases KW - Bone resorption KW - Transforming growth factor-b KW - Osteoclastogenesis KW - Osteogenesis KW - Signal transduction KW - W 30905:Medical Applications KW - N 14045:Transcriptional regulation KW - T 20010:Bone growth and remodelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20222598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Tumor+Necrosis+Factor+Promotes+Runx2+Degradation+through+Up-regulation+of+Smurf1+and+Smurf2+in+Osteoblasts&rft.au=Kaneki%2C+Hiroyuki%3BGuo%2C+Ruolin%3BChen%2C+Di%3BYao%2C+Zhenqiang%3BSchwarz%2C+Edward+M%3BZhang%2C+Ying+E%3BBoyce%2C+Brendan+F%3BXing%2C+Lianping&rft.aulast=Kaneki&rft.aufirst=Hiroyuki&rft.date=2006-02-01&rft.volume=281&rft.issue=7&rft.spage=4326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Tumor necrosis factor; Cbfa-1 protein; Osteoclasts; Interleukin 1; proteasomes; Transgenic mice; Inflammation; Ubiquitin-protein ligase; Osteoblasts; Bone morphogenetic proteins; Glial stem cells; Inflammatory diseases; siRNA; Transcription factors; Bone loss; Transforming growth factor- beta; Bone diseases; Osteoprogenitor cells; Transforming growth factor-b; Bone resorption; Osteoclastogenesis; Signal transduction; Osteogenesis ER - TY - JOUR T1 - Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake AN - 20220673; 6715132 AB - ADP-ribosylation factors (ARFs) are critical in vesicular trafficking. Brefeldin A-inhibited guanine nucleotide-exchange protein (BIG)1 and BIG2 activate ARFs by accelerating replacement of bound GDP with GTP. Additional and differing functions of these approximately 200-kDa proteins are now being recognized, as are their independent intracellular movements. Here, we describe the localization in COS7 cells by immunofluorescence microscopy of BIG2, but not BIG1, with structures that have characteristics of recycling endosomes during transferrin (Tfn) uptake and Tfn receptor (TfnR) recycling. Cell content of BIG2 and Rab11, but not TfnR, BIG1, Rab4, or Exo70, was increased after 60 min of Tfn uptake. BIG2, but not BIG1, appeared in density-gradient fractions containing TfnR, Rab11, and Exo70 after 60 min of Tfn uptake. Treatment of cells with BIG2 small interfering RNA (siRNA), but not BIG1 or control siRNAs, decreased BIG2 protein >90% without affecting BIG1, ARF, or actin content, whereas TfnR was significantly increased as was its accumulation in perinuclear recycling endosomes. Tfn release appeared unaffected by BIG1 siRNA but was significantly slowed from cells treated with BIG2 siRNA alone or plus BIG1 siRNA. We suggest that BIG2 has an important role in Tfn uptake and TfnR recycling, perhaps through its demonstrated interaction with Exo70 and the exocyst complex. JF - Proceedings of the National Academy of Sciences, USA AU - Shen, Xiaoyan AU - Xu, Kai-Feng AU - Fan, Qingyuan AU - Pacheco-Rodriguez, Gustavo AU - Moss, Joel AU - Vaughan, Martha AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 2635 EP - 2640 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 8 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - ADP-ribosylation factor KW - GTP KW - Immunofluorescence KW - Recycling KW - guanine nucleotide exchange factor KW - Transferrin KW - Guanine KW - endosomes KW - GDP KW - siRNA KW - Microscopy KW - Protein turnover KW - Actin KW - W 30900:Methods KW - N 14080:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20220673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Association+of+brefeldin+A-inhibited+guanine+nucleotide-exchange+protein+2+%28BIG2%29+with+recycling+endosomes+during+transferrin+uptake&rft.au=Shen%2C+Xiaoyan%3BXu%2C+Kai-Feng%3BFan%2C+Qingyuan%3BPacheco-Rodriguez%2C+Gustavo%3BMoss%2C+Joel%3BVaughan%2C+Martha&rft.aulast=Shen&rft.aufirst=Xiaoyan&rft.date=2006-02-01&rft.volume=57&rft.issue=12&rft.spage=1054&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/10.1136%2Fthorax.57.12.1054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - ADP-ribosylation factor; GTP; Immunofluorescence; Recycling; endosomes; Guanine; Transferrin; guanine nucleotide exchange factor; siRNA; GDP; Microscopy; Protein turnover; Actin ER - TY - JOUR T1 - Four-dimensional ultrasonography of the fetal heart using a novel Tomographic Ultrasound Imaging display AN - 20213747; 7849744 AB - Objective: The objective of this study was to investigate the feasibility of examining the fetal heart with Tomographic Ultrasound Imaging (TUI) using four-dimensional (4D) volume datasets acquired with spatiotemporal image correlation (STIC).Material and methods: One hundred and ninety-five fetuses underwent 4D ultrasonography (US) of the fetal heart with STIC. Volume datasets were acquired with B-mode (n=195) and color Doppler imaging (CDI) (n=168), and were reviewed offline using TUI, a new display modality that automatically slices 3D/4D volume datasets, providing simultaneous visualization of up to eight parallel planes in a single screen. Visualization rates for standard transverse planes used to examine the fetal heart were calculated and compared for volumes acquired with B-mode or CDI. Diagnoses by TUI were compared to postnatal diagnoses.Results: (1) The four- and five-chamber views and the three-vessel and trachea view were visualized in 97.4% (190/195), 88.2% (172/195), and 79.5% (142/195), respectively, of the volume datasets acquired with B-mode; (2) these views were visualized in 98.2% (165/168), 97.0% (163/168), and 83.6% (145/168), respectively, of the volume datasets acquired with CDI; (3) CDI contributed additional diagnostic information to 12.5% (21/168), 14.2% (24/168) and 10.1% (17/168) of the four- and five-chamber and the three-vessel and trachea views; (4) cardiac anomalies other than isolated ventricular septal defects were identified by TUI in 16 of 195 fetuses (8.2%) and, among these, CDI provided additional diagnostic information in 5 (31.3%); (5) the sensitivity, specificity, positive- and negative-predictive values of TUI to diagnose congenital heart disease in cases where both B-mode and CDI volume datasets were acquired prenatally were 92.9%, 98.8%, 92.9% and 98.8%, respectively.Conclusion: Standard transverse planes commonly used to examine the fetal heart can be automatically displayed with TUI in the majority of fetuses undergoing 4D US with STIC. Due to the retrospective nature of this study, the results should be interpreted with caution and independently confirmed before this methodology is introduced into clinical practice. JF - Journal of Perinatal Medicine AU - GonASCalves, LuASHs F AU - Espinoza, Jimmy AU - Romero, Roberto AU - Kusanovic, Juan Pedro AU - Swope, Betsy AU - Nien, Jyh Kae AU - Erez, Offer AU - Soto, Eleazar AU - Treadwell, Marjorie C AD - Perinatology Research Branch, National Institute of Child Health and Human Development, NIH/DHHS, Bethesda, Maryland, and Detroit, Michigan, USA and Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, Michigan, USA, warfiela@mail.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 39 EP - 55 PB - Walter de Gruyter und Co., Genthiner Str. 13 VL - 34 IS - 1 SN - 0300-5577, 0300-5577 KW - Biotechnology and Bioengineering Abstracts KW - Congenital heart disease KW - fetal echocardiography KW - four-dimensional KW - prenatal diagnosis KW - spatiotemporal KW - spatiotemporal image correlation KW - three-dimensional KW - 3D KW - 4D KW - Heart KW - Doppler effect KW - Reviews KW - imaging KW - Ultrasonography KW - Ultrasound KW - Trachea KW - Fetuses KW - Color KW - Heart diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20213747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatal+Medicine&rft.atitle=Four-dimensional+ultrasonography+of+the+fetal+heart+using+a+novel+Tomographic+Ultrasound+Imaging+display&rft.au=GonASCalves%2C+LuASHs+F%3BEspinoza%2C+Jimmy%3BRomero%2C+Roberto%3BKusanovic%2C+Juan+Pedro%3BSwope%2C+Betsy%3BNien%2C+Jyh+Kae%3BErez%2C+Offer%3BSoto%2C+Eleazar%3BTreadwell%2C+Marjorie+C&rft.aulast=GonASCalves&rft.aufirst=LuASHs&rft.date=2006-02-01&rft.volume=34&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatal+Medicine&rft.issn=03005577&rft_id=info:doi/10.1515%2FJPM.2006.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Doppler effect; Reviews; Trachea; Ultrasound; Ultrasonography; imaging; Fetuses; Heart diseases; Color DO - http://dx.doi.org/10.1515/JPM.2006.006 ER - TY - JOUR T1 - The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism AN - 19980664; 6666415 AB - Several studies show that transcription coactivators are often bi-functional ribonucleoprotein complexes that also regulate pre-mRNA processing and splicing decisions. Using sensitive sequence profile searches and structural comparisons we show that the C-terminal domain of the human coactivator protein ASC-1 defines a novel superfamily, the ASC-1 homology (ASCH) domain. The approximately 110 amino acid long ASCH domains are widely represented in all the three superkingdoms of life and several prokaryotic viruses. We show that the ASCH superfamily adopts a beta-barrel fold similar to the PUA domain superfamily. Using multiple lines of evidence, we suggest that members of the ASCH superfamily are likely to function as RNA-binding domains in contexts related to coactivation, RNA-processing and possibly prokaryotic translation regulation. Structural analysis of ASCH domains reveals the presence of a potential RNA-binding cleft associated with a conserved sequence motif, which is characteristic of this superfamily. Despite their similar structure, the ASCH and PUA domains appear to occupy distinct functional niches, with the former domains typically occurring in a standalone form in polypeptides, and the latter domains showing fusions to a variety of RNA-modifying enzymes. Supplementary information: A complete alignment of all ASCH domains in the NR-database and other domains found fused to the ASCH can be retrieved from ftp://ftp.ncbi.nih.gov/pub/aravind/ JF - Bioinformatics AU - Iyer, Lakshminarayan M AU - Burroughs, AMaxwell AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA, aravind@ncbi.nlm.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 257 EP - 263 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 3 SN - 1367-4803, 1367-4803 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - Amino acids KW - Niches KW - Transcription KW - Enzymes KW - Splicing KW - Homology KW - RNA KW - Ribonucleoproteins KW - Conserved sequence KW - Bioinformatics KW - Metabolism KW - N 14830:RNA KW - V 22310:Genetics, Taxonomy & Structure KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cablefax&rft.atitle=At+Home%3A+19-3%2F4%2C+dn+1%2F4+Adelphia%3A+8-9%2F16%2C+dn+5%2F16+Ameritech%3A+68-9%2F16%2C+dn+1%2F4+ATEL%3A+1-1%2F8%2C+up+1%2F8+Antec%3A+13-7%2F16%2C+unch+Ascent%3A+11-9%2F16%2C+dn+5%2F16+AT%26amp%3BT%3A+40-5%2F8%2C+dn+1-1%2F8+Bell+Atlantic%3A+75-5%2F8%2C+dn+1%2F8+BellSouth%3A+48-1%2F16%2C+dn+1%2F16+BET%3A+39-1%2F4%2C+dn+1%2F8+Blonder+Tongue%3A+10-3%2F4%2C+up+1%2F2+Box+Worldwide%3A+1-3%2F32%2C+dn+1%2F32+Cablevision%3A+57-1%2F16%2C+up+9%2F16+CAI+Wireless%3A+1-1%2F2%2C+up+3%2F16+C-COR%3A+11-1%2F4%2C+unch+Cellularvision%3A+7-3%2F4%2C+up+1%2F4+Century%3A+6-1%2F8%2C+up+3%2F16+Comcast+Cp+Sp%3A+23-1%2F2%2C+up+1%2F4+CommScope%3A+16-9%2F16%2C+dn+5%2F16+Cox%3A+26-13%2F16%2C+up+1%2F8+C-TEC%3A+35-15%2F16%2C+dn+5%2F16+Disney%3A+78-3%2F8%2C+dn+1-1%2F4+EchoStar%3A+14-1%2F2%2C+up+23%2F32+Family%3A+34-5%2F8%2C+up+1%2F16+GE%3A+66-3%2F16%2C+dn+1-7%2F16+GI%3A%2C+unch%2C+unch+GM+Hughes%3A+63-5%2F16%2C+unch+GTE%3A+47-9%2F16%2C+dn+1%2F8+HSNI%3A+31-1%2F8%2C+dn+1-1%2F4+Jones+A%3A+12-1%2F8%2C+dn+1%2F8+Liberty%3A+25-11%2F16%2C+up+3%2F16+MCI%3A+34-7%2F16%2C+up+7%2F16+Media+General%3A+35-1%2F2%2C+dn+1%2F2+Microsoft%3A+136%2C+dn+2-1%2F4+NextLevel%3A+19-5%2F8%2C+dn+13%2F16+News+Corp%3A+17-1%2F2%2C+dn+1%2F16+Nynex%3A+56-15%2F16%2C+dn+15%2F16+People%27s+Choice%3A+2%2C+dn+1%2F4+Philips%3A+76-7%2F8%2C+dn+1-3%2F8+Playboy%3A+11-5%2F16%2C+dn+1%2F16+S-A%3A&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1997-08-13&rft.volume=8&rft.issue=93&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cablefax&rft.issn=10696644&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Splicing; Amino acids; RNA; Homology; Niches; Ribonucleoproteins; Conserved sequence; Enzymes; Transcription; Bioinformatics; Metabolism ER - TY - JOUR T1 - A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection AN - 19980212; 6663305 AB - Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times. JF - Antimicrobial Agents & Chemotherapy AU - Kocisko, David A AU - Caughey, Winslow S AU - Race, Richard E AU - Roper, Grant AU - Caughey, Byron AU - Morrey, John D AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana. Institute for Antiviral Research, Animal, Dairy, and Veterinary Sciences Department, Utah State University, Logan, Utah Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 759 EP - 761 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 2 SN - 0066-4804, 0066-4804 KW - Fe(III)meso-tetra(4-sulfonatophenyl)porphine KW - mice KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Porphyrins KW - Neurodegenerative diseases KW - Prion protein KW - Brain KW - Inoculation KW - Survival KW - Scrapie KW - Infection KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - V 22130:Diseases associated with slow viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=A+Porphyrin+Increases+Survival+Time+of+Mice+after+Intracerebral+Prion+Infection&rft.au=Kocisko%2C+David+A%3BCaughey%2C+Winslow+S%3BRace%2C+Richard+E%3BRoper%2C+Grant%3BCaughey%2C+Byron%3BMorrey%2C+John+D&rft.aulast=Kocisko&rft.aufirst=David&rft.date=2006-02-01&rft.volume=50&rft.issue=2&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Porphyrins; Inoculation; Brain; Prion protein; Survival; Scrapie; Infection; Antimicrobial agents ER - TY - JOUR T1 - Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case-control study AN - 19960776; 6663995 AB - Non-Hodgkin Lymphoma (NHL) incidence has risen dramatically over past decades, but the reasons for most of this increase are not known. Meat cooked well-done using high-temperature cooking techniques produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P). This study was conducted as a population-based case-control study in Iowa, Detroit, Seattle and Los Angeles and was designed to determine whether meat, meat-cooking methods, HCAs or PAHs from meat were associated with NHL risk. This study consisted of 458 NHL cases, diagnosed between 1998 and 2000, and 383 controls. Participants completed a 117-item food frequency questionnaire (FFQ), with graphical aids to assess the meat-cooking method and doneness level, which was linked to a HCA and B[a]P database. Logistic regression, comparing the fourth to the first quartile, found no association between red meat or processed meat intake and risk for NHL [odds ratio (OR) and 95% confidence interval (CI): 1.10 (0.67-1.81) and 1.18 (0.74-1.89), respectively]. A marginally significant elevated risk for NHL was associated with broiled meat [OR and 95% CI: 1.32 (0.99-1.77); P trend = 0.09], comparing those who consumed broiled meat with those who did not. The degree to which meat was cooked was not associated with the risk for NHL, although one of the HCAs, DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), was associated with an inverse risk. Fat intake was associated with a significantly elevated risk for NHL [OR and 95% CI: 1.60 (1.05-2.45); P trend = 0.12]; in contrast, animal protein was inversely associated with risk for NHL [OR and 95% CI: 0.39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL. JF - Carcinogenesis AU - Cross, Amanda J AU - Ward, Mary H AU - Schenk, MaryJean AU - Kulldorff, Martin AU - Cozen, Wendy AU - Davis, Scott AU - Colt, Joanne S AU - Hartge, Patricia AU - Cerhan, James R AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA, Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI 48201, USA, Department of Ambulatory Care and Prevention Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA, University of Southern California, Los Angeles, CA 90089, USA, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA and Mayo Clinic College of Medicine, Rochester, MN 55904, USA Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 293 EP - 297 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 2 SN - 0143-3334, 0143-3334 KW - Immunology Abstracts; Toxicology Abstracts KW - Heterocyclic amines KW - Inventories KW - Polycyclic aromatic hydrocarbons KW - Food KW - Meat KW - Databases KW - Food sources KW - Carcinogenesis KW - Cooking KW - Benzo(a)pyrene KW - Lymphoma KW - Fat metabolism KW - X 24120:Food, additives & contaminants KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Meat+and+meat-mutagen+intake+and+risk+of+non-Hodgkin+lymphoma%3A+results+from+a+NCI-SEER+case-control+study&rft.au=Cross%2C+Amanda+J%3BWard%2C+Mary+H%3BSchenk%2C+MaryJean%3BKulldorff%2C+Martin%3BCozen%2C+Wendy%3BDavis%2C+Scott%3BColt%2C+Joanne+S%3BHartge%2C+Patricia%3BCerhan%2C+James+R%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2006-02-01&rft.volume=27&rft.issue=2&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Meat; Inventories; Heterocyclic amines; Databases; Polycyclic aromatic hydrocarbons; Food sources; Food; Cooking; Carcinogenesis; Benzo(a)pyrene; Lymphoma; Fat metabolism ER - TY - JOUR T1 - Safety and Pharmacokinetics of Intravenous Anidulafungin in Children with Neutropenia at High Risk for Invasive Fungal Infections AN - 19958288; 6663286 AB - Anidulafungin is an echinocandin with activity against Candida species and Aspergillus species. Adult dosages under study are 50 mg/day for esophageal candidiasis and 100 mg/day for invasive candidiasis and aspergillosis. Little is known, however, about the safety and pharmacokinetics of anidulafungin in children. A multicenter, ascending-dosage study of neutropenic pediatric patients was therefore conducted. Patients were divided into two age cohorts (2 to 11 years and 12 to 17 years) and were enrolled into sequential groups to receive 0.75 or 1.5 mg/kg of body weight/day. Blood samples were obtained following the first and fifth doses. Anidulafungin was assayed in plasma, and pharmacokinetic parameters were determined. Safety was assessed using National Cancer Institute (NCI) common toxicity criteria. Pharmacokinetic parameters were determined for 12 patients at each dosage (0.75 mg/kg/day or 1.5 mg/kg/day). Concentrations and drug exposures were similar for patients between age cohorts, and weight-adjusted clearance was consistent across age. No drug-related serious adverse events were observed. One patient had fever (NCI toxicity grade of 3), and one patient had facial erythema, which resolved with slowing the infusion rate. Anidulafungin in pediatric patients was well tolerated and can be dosed based on body weight. Pediatric patients receiving 0.75 mg/kg/day or 1.5 mg/kg/day have anidulafungin concentration profiles similar to those of adult patients receiving 50 or 100 mg/day, respectively. JF - Antimicrobial Agents & Chemotherapy AU - Benjamin, Daniel KJr AU - Driscoll, Timothy AU - Seibel, Nita L AU - Gonzalez, Corina E AU - Roden, Maureen M AU - Kilaru, Rahki AU - Clark, Kay AU - Dowell, James A AU - Schranz, Jennifer AU - Walsh, Thomas J AD - Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, North Carolina. Children's National Medical Center, Washington, D.C. Georgetown University, Washington, D.C. National Cancer Institute, Bethesda, Maryland. Vicuron Pharmaceuticals, King of Prussia, Pennsylvania Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 632 EP - 638 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Risk assessment KW - Esophagus KW - Intravenous administration KW - Erythema KW - Age KW - Candidiasis KW - Pediatrics KW - Candida KW - Aspergillosis KW - Aspergillus KW - Toxicity KW - Children KW - Infection KW - Cancer KW - Pharmacokinetics KW - Antimicrobial agents KW - Fever KW - Neutropenia KW - Body weight KW - Risk factors KW - echinocandins KW - A 01340:Antibiotics & Antimicrobials KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19958288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Toronto+Star&rft.atitle=%5BEASTERN+CONFERENCE+Atlantic+Division+Pittsburgh+3+1+1+1+0+3+14+14+1-+1-1+0-0-1-0+1-1-0-0+NY+Rangers+4+1+2+1+0+3+6...%5D%3A+%5B%3Cspan+class%3D%22hit%22%3E1%3C%2Fspan%3E+Edition%5D&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1999-10-10&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toronto+Star&rft.issn=03190781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Esophagus; Risk assessment; Age; Erythema; Intravenous administration; Candidiasis; Pediatrics; Aspergillosis; Toxicity; Infection; Children; Pharmacokinetics; Cancer; Antimicrobial agents; Fever; Neutropenia; Body weight; Risk factors; echinocandins; Candida; Aspergillus ER - TY - JOUR T1 - Fluconazole Treatment Is Effective against a Candida albicans erg3/erg3 Mutant In Vivo Despite In Vitro Resistance AN - 19956755; 6663279 AB - Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol. Defective sterol C5,6 desaturation has been considered to be one of the azole resistance mechanisms in this species. However, the clinical relevance of this resistance mechanism is still unclear. In this study, we created a C. albicans erg3/erg3 mutant by the "Ura-blaster" method and confirmed the expected azole resistance using standard in vitro testing and the presence of ergosta-7,22-dien-3 beta -ol instead of ergosterol. For in vivo studies, a wild-type URA3 was placed back into its native locus in the erg3 homozygote to avoid positional effects on URA3 expression. Defective hyphal formation of the erg3 homozygote was observed not only in vitro but in kidney tissues. A marked attenuation of virulence was shown by the longer survival and the lower kidney burdens of mice inoculated with the reconstituted Ura super(+) erg3 homozygote relative to the control. To assess fluconazole efficacy in a murine model of disseminated candidiasis, inoculum sizes of the control and the erg3 homozygote were chosen which provided a similar organ burden. Under these conditions, fluconazole was highly effective in reducing the organ burden in both groups. This study demonstrates that an ERG3 mutation causing inactivation of sterol C5,6-desaturase cannot confer fluconazole resistance in vivo by itself regardless of resistance measured by standard in vitro testing. The finding questions the clinical significance of this resistance mechanism. JF - Antimicrobial Agents & Chemotherapy AU - Miyazaki, Taiga AU - Miyazaki, Yoshitsugu AU - Izumikawa, Koichi AU - Kakeya, Hiroshi AU - Miyakoshi, Shunichi AU - Bennett, John E AU - Kohno, Shigeru AD - Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501. Lead Discovery Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 580 EP - 586 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Candidiasis KW - Animal models KW - Survival KW - Candida albicans KW - Homozygotes KW - Antimicrobial agents KW - Virulence KW - fluconazole KW - Sterols KW - Inoculum KW - Kidney KW - Ergosterol KW - Mutation KW - azoles KW - A 01340:Antibiotics & Antimicrobials KW - K 03087:Fungi: human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19956755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Hotline.+National+Journal%27s+Daily+Briefing+on+Politics+%28Online%29&rft.atitle=Where+There%27s+Scandal%2C+There%27s+a+Member+on+TV.&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Hotline.+National+Journal%27s+Daily+Briefing+on+Politics+%28Online%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Candidiasis; Animal models; Survival; Homozygotes; Antimicrobial agents; Virulence; fluconazole; Sterols; Kidney; Inoculum; Ergosterol; Mutation; azoles; Candida albicans ER - TY - JOUR T1 - Epigenetics of Germ Cells, Stem Cells, and Early Embryos AN - 19954935; 6672896 AB - The International Symposium entitled "Germ Cells, Epigenetics, Reprogramming, and Embryonic Stem Cells" was organized by Norio Nakatsuji (Kyoto University) and Hiromitsu Nakauchi (University of Tokyo) in Kyoto, Japan (November 15-18, 2005). The meeting provided an overview of this important research area and highlighted recent advances. JF - Developmental Cell AU - Ko, Minoru SH AU - McLaren, Anne AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, kom@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 161 EP - 166 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 10 IS - 2 SN - 1534-5807, 1534-5807 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Embryo cells KW - epigenetics KW - Reviews KW - Germ cells KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19954935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Cell&rft.atitle=Epigenetics+of+Germ+Cells%2C+Stem+Cells%2C+and+Early+Embryos&rft.au=Ko%2C+Minoru+SH%3BMcLaren%2C+Anne&rft.aulast=Ko&rft.aufirst=Minoru&rft.date=2006-02-01&rft.volume=10&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Developmental+Cell&rft.issn=15345807&rft_id=info:doi/10.1016%2Fj.devcel.2006.01.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Embryo cells; epigenetics; Reviews; Germ cells DO - http://dx.doi.org/10.1016/j.devcel.2006.01.008 ER - TY - JOUR T1 - Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the p47 super(phox) super(-) super(/) super(-) Mouse Model of Chronic Granulomatous Disease AN - 19954519; 6663258 AB - Chronic granulomatous disease (CGD) is an inherited disorder of the NADPH oxidase characterized by recurrent life-threatening bacterial and fungal infections. We characterized the effects of single and combination antifungal therapy on survival, histopathology, and laboratory markers of fungal burden in experimental aspergillosis in the p47 super(phox) super(-) super(/) super(-) knockout mouse model of CGD. CGD mice were highly susceptible to intratracheal Aspergillus fumigatus challenge, whereas wild-type mice were resistant. CGD mice were challenged intratracheally with a lethal inoculum (1.25 x 10 super(4) CFU/mouse) of A. fumigatus and received one of the following regimens daily from day 0 to 4 after challenge (n = 19 to 20 per treatment group): (i) vehicle, (ii) amphotericin B (intraperitoneal; 1 mg/kg of body weight), (iii) micafungin (intravenous; 10 mg/kg), or (iv) amphotericin B plus micafungin. The rank order of therapeutic efficacy based on prolonged survival, from highest to lowest, was as follows: amphotericin B plus micafungin, amphotericin B alone, micafungin alone, and the vehicle. Lung histology showed pyogranulomatous lesions and invasive hyphae, but without hyphal angioinvasion or coagulative necrosis. Treatment with micafungin alone or combined with amphotericin B produced swelling of invasive hyphae that was not present in mice treated with the vehicle or amphotericin B alone. Assessment of lung fungal burden by quantitative PCR showed no significant difference between treatment groups. Serum galactomannan levels were at background despite documentation of invasive aspergillosis by histology. Our findings showed the superior efficacy of the amphotericin B and micafungin combination compared to either agent alone after A. fumigatus challenge and also demonstrated unique features of CGD mice as a model for experimental aspergillosis. JF - Antimicrobial Agents & Chemotherapy AU - Dennis, Carly G AU - Greco, William R AU - Brun, Yseult AU - Youn, Richard AU - Slocum, Harry K AU - Bernacki, Ralph J AU - Lewis, Russell AU - Wiederhold, Nathan AU - Holland, Steven M AU - Petraitiene, Ruta AU - Walsh, Thomas J AU - Segal, Brahm H AD - Departments of Medicine. Biostatistics. Pharmacology and Therapeutics. Immunology, Roswell Park Cancer Institute, Buffalo, New York. University of Houston College of Pharmacy, M. D. Anderson Cancer Center, Houston, Texas. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 422 EP - 427 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Intravenous administration KW - Hereditary diseases KW - micafungin KW - Hyphae KW - Animal models KW - Survival KW - Aspergillosis KW - Antimicrobial agents KW - Necrosis KW - Body weight KW - Lung KW - Aspergillus fumigatus KW - Colony-forming cells KW - Chronic infection KW - Inoculum KW - Polymerase chain reaction KW - Recurrent infection KW - NAD(P)H oxidase KW - Chronic granulomatous disease KW - Trachea KW - NADPH oxidase KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - K 03092:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19954519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effect+of+Amphotericin+B+and+Micafungin+Combination+on+Survival%2C+Histopathology%2C+and+Fungal+Burden+in+Experimental+Aspergillosis+in+the+p47+super%28phox%29+super%28-%29+super%28%2F%29+super%28-%29+Mouse+Model+of+Chronic+Granulomatous+Disease&rft.au=Dennis%2C+Carly+G%3BGreco%2C+William+R%3BBrun%2C+Yseult%3BYoun%2C+Richard%3BSlocum%2C+Harry+K%3BBernacki%2C+Ralph+J%3BLewis%2C+Russell%3BWiederhold%2C+Nathan%3BHolland%2C+Steven+M%3BPetraitiene%2C+Ruta%3BWalsh%2C+Thomas+J%3BSegal%2C+Brahm+H&rft.aulast=Dennis&rft.aufirst=Carly&rft.date=2006-02-01&rft.volume=50&rft.issue=2&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Intravenous administration; Hereditary diseases; micafungin; Hyphae; Animal models; Survival; Aspergillosis; Antimicrobial agents; Necrosis; Body weight; Lung; Colony-forming cells; Chronic infection; Inoculum; Polymerase chain reaction; NAD(P)H oxidase; Recurrent infection; Chronic granulomatous disease; Trachea; NADPH oxidase; Aspergillus fumigatus ER - TY - JOUR T1 - Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells AN - 19953698; 6662443 AB - We established a method for production of recombinant adeno-associated virus type 5 (rAAV5) in insect cells by use of baculovirus expression vectors. One baculovirus harbors a transgene between the inverted terminal repeat sequences of type 5, and the second expresses Rep78 and Rep52. Interestingly, the replacement of type 5 Rep52 with type 1 Rep52 generated four times more rAAV5 particles. We replaced the N-terminal portion of type 5 VP1 with the equivalent portion of type 2 to generate infectious AAV5 particles. The rAAV5 with the modified VP1 required alpha 2-3 sialic acid for transduction, as revealed by a competition experiment with an analog of alpha 2-3 sialic acid. rAAV5-GFP/Neo with a 4.4-kb vector genome produced in HEK293 cells or Sf9 cells transduced COS cells with similar efficiencies. Surprisingly, Sf9-produced humanized Renilla green fluorescent protein (hGFP) vector with a 2.4-kb vector genome induced stronger GFP expression than the 293-produced one. Transduction of murine skeletal muscles with Sf9-generated rAAV5 with a 3.4-kb vector genome carrying a human secreted alkaline phosphatase (SEAP) expression cassette induced levels of SEAP more than 30 times higher than those for 293-produced vector 1 week after injection. Analysis of virion DNA revealed that in addition to a 2.4- or 3.4-kb single-stranded vector genome, Sf9-rAAV5 had more-abundant forms of approximately 4.7 kb, which appeared to correspond to the monomer duplex form of hGFP vector or truncated monomer duplex SEAP vector DNA. These results indicated that rAAV5 can be generated in insect cells, although the difference in incorporated virion DNA may induce different expression patterns of the transgene. JF - Journal of Virology AU - Urabe, Masashi AU - Nakakura, Takayo AU - Xin, Ke-Qin AU - Obara, Yoko AU - Mizukami, Hiroaki AU - Kume, Akihiro AU - Kotin, Robert M AU - Ozawa, Keiya AD - Division of Genetic Therapeutics, Jichi Medical School, Tochigi 329-0498, Japan. Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1874 EP - 1885 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 4 SN - 0022-538X, 0022-538X KW - Rep78 protein KW - Rep52 protein KW - Entomology Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Genomes KW - Green fluorescent protein KW - Expression vectors KW - Adeno-associated virus 5 KW - Insect cells KW - Renilla KW - Skeletal muscle KW - VP1 protein KW - Monomers KW - Alkaline phosphatase KW - DNA KW - Baculovirus KW - Sialic acids KW - Transduction KW - W3 33181:Gene therapy vectors KW - V 22023:Virus behavior in cell culture KW - Z 05360:Genetics and Evolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19953698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Scalable+Generation+of+High-Titer+Recombinant+Adeno-Associated+Virus+Type+5+in+Insect+Cells&rft.au=Urabe%2C+Masashi%3BNakakura%2C+Takayo%3BXin%2C+Ke-Qin%3BObara%2C+Yoko%3BMizukami%2C+Hiroaki%3BKume%2C+Akihiro%3BKotin%2C+Robert+M%3BOzawa%2C+Keiya&rft.aulast=Urabe&rft.aufirst=Masashi&rft.date=2006-02-01&rft.volume=80&rft.issue=4&rft.spage=1874&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Adeno-associated virus 5; Baculovirus; Renilla; Expression vectors; Genomes; Insect cells; Transduction; Virions; VP1 protein; Sialic acids; Skeletal muscle; Green fluorescent protein; Alkaline phosphatase; Monomers; DNA ER - TY - JOUR T1 - In Vitro Preclinical Testing of Nonoxynol-9 as Potential Anti-Human Immunodeficiency Virus Microbicide: a Retrospective Analysis of Results from Five Laboratories AN - 19950608; 6663297 AB - The first product to be clinically evaluated as a microbicide contained the nonionic surfactant nonoxynol-9 (nonylphenoxypolyethoxyethanol; N-9). Many laboratories have used N-9 as a control compound for microbicide assays. However, no published comparisons of the results among laboratories or attempts to establish standardized protocols for preclinical testing of microbicides have been performed. In this study, we compared results from 127 N-9 toxicity and 72 efficacy assays that were generated in five different laboratories over the last six years and were performed with 14 different cell lines or tissues. Intra-assay reproducibility was measured at two-, three-, and fivefold differences using standard deviations. Interassay reproducibility was assessed using general linear models, and interaction between variables was studied using step-wise regression. The intra-assay reproducibility within the same N-9 concentration, cell type, assay duration, and laboratory was consistent at the twofold level of standard deviations. For interassay reproducibility, cell line, duration of assay, and N-9 concentration were all significant sources of variability (P 24 h) and short (<2 h) exposures of cells to N-9 showed variability, while assays with 4 to 8 h of N-9 exposure gave results that were not significantly different. This is the first analysis to compare preclinical N-9 toxicity levels that were obtained by different laboratories using various protocols. This comparative work can be used to develop standardized microbicide testing protocols that will help advance potential microbicides to clinical trials. JF - Antimicrobial Agents & Chemotherapy AU - Beer, Brigitte E AU - Doncel, Gustavo F AU - Krebs, Fred C AU - Shattock, Robin J AU - Fletcher, Patricia S AU - Buckheit, Robert WJr AU - Watson, Karen AU - Dezzutti, Charlene S AU - Cummins, James E AU - Bromley, Ena AU - Richardson-Harman, Nicola AU - Pallansch, Luke A AU - Lackman-Smith, Carol AU - Osterling, Clay AU - Mankowski, Marie AU - Miller, Shendra R AU - Catalone, Bradley J AU - Welsh, Patricia A AU - Howett, Mary K AU - Wigdahl, Brian AU - Turpin, Jim A AU - Reichelderfer, Patricia AD - Southern Research Institute, Frederick, Maryland. CONRAD, Eastern Virginia Medical School, Norfolk, Virginia. Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Diseases, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129. University of London, London, United Kingdom. Imquest BioSciences, Inc., Frederick, Maryland. Centers for Disease Control and Prevention, Atlanta, Georgia. BioStat Solutions, Inc., Mt. Airy, Maryland. Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania 17033. Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 713 EP - 723 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 2 SN - 0066-4804, 0066-4804 KW - HIV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Standard deviation KW - Human immunodeficiency virus KW - Regression analysis KW - Toxicity KW - Clinical trials KW - Surfactants KW - microbicides KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - V 22002:AIDS: Molecular and in vitro aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19950608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Preclinical+Testing+of+Nonoxynol-9+as+Potential+Anti-Human+Immunodeficiency+Virus+Microbicide%3A+a+Retrospective+Analysis+of+Results+from+Five+Laboratories&rft.au=Beer%2C+Brigitte+E%3BDoncel%2C+Gustavo+F%3BKrebs%2C+Fred+C%3BShattock%2C+Robin+J%3BFletcher%2C+Patricia+S%3BBuckheit%2C+Robert+WJr%3BWatson%2C+Karen%3BDezzutti%2C+Charlene+S%3BCummins%2C+James+E%3BBromley%2C+Ena%3BRichardson-Harman%2C+Nicola%3BPallansch%2C+Luke+A%3BLackman-Smith%2C+Carol%3BOsterling%2C+Clay%3BMankowski%2C+Marie%3BMiller%2C+Shendra+R%3BCatalone%2C+Bradley+J%3BWelsh%2C+Patricia+A%3BHowett%2C+Mary+K%3BWigdahl%2C+Brian%3BTurpin%2C+Jim+A%3BReichelderfer%2C+Patricia&rft.aulast=Beer&rft.aufirst=Brigitte&rft.date=2006-02-01&rft.volume=50&rft.issue=2&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Standard deviation; Regression analysis; Toxicity; Surfactants; Clinical trials; Antimicrobial agents; microbicides; Human immunodeficiency virus ER - TY - JOUR T1 - Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice AN - 19846690; 7428081 AB - This study analyzes gene expression associated with papilloma development in Tg.AC v-Ha-ras transgenic mice and identifies novel genes and biological processes that may be critical to skin carcinogenesis in these mice. Epidermal abrasion was used to synchronously induce epidermal regeneration in FVB/N wild type and transgenic Tg.AC mice. Skin papillomagenesis was uniquely induced in Tg.AC mice, and gene expression profiling was carried out using a 22 000 element mouse DNA microarray. Histological analysis showed that papillomas developed at a high rate by d 30 after abrasion in transgenic animals, while no papilloma developed in wild type mice. Transgene-specific differentially expressed genes were identified at d 30 postabrasion and these genes were annotated using EASE software and literature mining. Annotated and non-annotated genes associated with papilloma development were identified and clustering analysis revealed groups of genes that are coordinately expressed. A number of genes associated with differentiation and development were also physically clustered on mouse chromosome 16, including 16B3 that contains several Stefins and stefin-like genes, and 16A1 containing a number of keratin associated protein genes. Additional analyses presented here yield novel insights into the genes and processes involved in papilloma development in Tg.AC mice. JF - Molecular Carcinogenesis AU - Dang, H AU - Trempus, C AU - Malarkey, DE AU - Wei, S-J AU - Humble, M AU - Morris, R J AU - Tennant, R W AD - National Center for Toxicogenomics, NIEHS, P.O. Box 12233, MD# F1-05, 111 Alexander Drive, Research Triangle Park, NC 27709, USA Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 126 EP - 140 VL - 45 IS - 2 SN - 0899-1987, 0899-1987 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Skin KW - Abrasion KW - chromosome 16 KW - Transgenic mice KW - DNA microarrays KW - Computer programs KW - Differentiation KW - software KW - Keratin KW - Carcinogenesis KW - Mining KW - Papilloma KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19846690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Carcinogenesis&rft.atitle=Identification+of+genes+and+gene+ontology+processes+critical+to+skin+papilloma+development+in+Tg.AC+transgenic+mice&rft.au=Dang%2C+H%3BTrempus%2C+C%3BMalarkey%2C+DE%3BWei%2C+S-J%3BHumble%2C+M%3BMorris%2C+R+J%3BTennant%2C+R+W&rft.aulast=Dang&rft.aufirst=H&rft.date=2006-02-01&rft.volume=45&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Molecular+Carcinogenesis&rft.issn=08991987&rft_id=info:doi/10.1002%2Fmc.20154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Computer programs; software; Keratin; Skin; chromosome 16; Abrasion; Carcinogenesis; Mining; Transgenic mice; Papilloma; DNA microarrays DO - http://dx.doi.org/10.1002/mc.20154 ER - TY - JOUR T1 - An Essential Role of Alternative Splicing of c-myc Suppressor FUSE-Binding Protein-Interacting Repressor in Carcinogenesis AN - 19841545; 6660418 AB - Elevated expression of c-myc has been detected in a broad range of human cancers, indicating a key role for this oncogene in tumor development. Recently, an interaction between FUSE-binding protein-interacting repressor (FIR) and TFIIH/p89/XPB helicase was found to repress c-myc transcription and might be important for suppressing tumor formation. In this study, we showed that enforced expression of FIR induced apoptosis. Deletion of the NH sub(2)-terminal repression domain of FIR rescued the cells from apoptosis as did coexpression of c-Myc with FIR; thus, repression of Myc mediates FIR-driven apoptosis. Surprisingly, a splicing variant of FIR unable to repress c-myc or to drive apoptosis was frequently discovered in human primary colorectal cancers but not in the adjacent normal tissues. Coexpression of this splicing variant with repressor-competent FIR, either in HeLa cells or in the colon cancer cell line SW480, not only abrogated c-Myc suppression but also inhibited apoptosis. These results strongly suggest the expression of this splicing variant promotes tumor development by disabling FIR repression and sustaining high levels of c-Myc and opposing apoptosis in colorectal cancer. (Cancer Res 2006; 66(3): 1409-17) JF - Cancer Research AU - Matsushita, Kazuyuki AU - Tomonaga, Takeshi AU - Shimada, Hideaki AU - Shioya, Ayumi AU - Higashi, Morihiro AU - Matsubara, Hisahiro AU - Harigaya, Kenichi AU - Nomura, Fumio AU - Libutti, Daniel AU - Levens, David AU - Ochiai, Takenori AD - Departments of Frontier Surgery, Molecular Diagnosis, and Molecular Pathology, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan and Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1409 EP - 1417 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 3 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - Clonal deletion KW - Apoptosis KW - Colorectal cancer KW - Transcription KW - Colon cancer KW - Tumors KW - Alternative splicing KW - Myc protein KW - Tumor cell lines KW - Oncogenes KW - Carcinogenesis KW - DNA helicase KW - Repressors KW - c-Myc protein KW - B 26180:Myc oncogene/Mad and Max proteins KW - N 14045:Transcriptional regulation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19841545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=An+Essential+Role+of+Alternative+Splicing+of+c-myc+Suppressor+FUSE-Binding+Protein-Interacting+Repressor+in+Carcinogenesis&rft.au=Matsushita%2C+Kazuyuki%3BTomonaga%2C+Takeshi%3BShimada%2C+Hideaki%3BShioya%2C+Ayumi%3BHigashi%2C+Morihiro%3BMatsubara%2C+Hisahiro%3BHarigaya%2C+Kenichi%3BNomura%2C+Fumio%3BLibutti%2C+Daniel%3BLevens%2C+David%3BOchiai%2C+Takenori&rft.aulast=Matsushita&rft.aufirst=Kazuyuki&rft.date=2006-02-01&rft.volume=66&rft.issue=3&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Apoptosis; Clonal deletion; Colorectal cancer; Transcription; Tumors; Colon cancer; Alternative splicing; Myc protein; Tumor cell lines; Oncogenes; Carcinogenesis; Repressors; DNA helicase; c-Myc protein ER - TY - JOUR T1 - Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjoegren's syndrome AN - 19839587; 6659959 AB - BACKGROUND: Sjoegren's syndrome (SS), an autoimmune exocrinopathy mainly affecting lachrymal and salivary glands, results in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown; currently, only palliative treatment is available. OBJECTIVE: To determine whether gene transfer of vasoactive intestinal peptide (VIP), based on its immunomodulatory properties, might be useful in the management of SS. METHODS: A recombinant serotype 2 adeno-associated virus encoding the human VIP transgene (rAAV2hVIP) was constructed and its efficacy tested in the female non-obese diabetic (NOD) mouse model for SS after retrograde instillation in submandibular glands (SMGs). 10 super(10) particles/gland of rAAV2hVIP or rAAV2LacZ (encoding beta -galactosidase; control vector) were administered at 8 weeks of age (before sialadenitis onset). Salivary flow rates were determined before vector delivery and at time of death (16 weeks). After death, saliva, serum, and SMGs were harvested. Salivary output, inflammatory infiltrates (focus scores), VIP protein expression, cytokine profile, and serum anti-VIP antibodies were analysed. RESULTS: rAAV2hVIP significantly improved the salivary flow, increased SMG and serum expression of VIP, and reduced SMG cytokines interleukin (IL) 2, IL10, IL12 (p70), and tumour necrosis factor alpha , and serum RANTES, compared with the control vector. No difference in focus scores or apoptotic rates was found; neutralising antibodies were not detected. CONCLUSIONS: Local delivery of rAAV2hVIP can have disease modifying and immunosuppressive effects in SMGs of the NOD mouse model of SS. The new strategy of employing VIP prophylactically may be useful for both understanding and managing the salivary component of SS. JF - Annals of the Rheumatic Diseases AU - Lodde, B M AU - Mineshiba, F AU - Wang, J AU - Cotrim, A P AU - Afione, S AU - Tak, P P AU - Baum, B J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1190, USA. Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 195 EP - 200 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 2 SN - 0003-4967, 0003-4967 KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Age KW - Apoptosis KW - Serotypes KW - Interleukins KW - Animal models KW - Salivary gland KW - Immunomodulation KW - Adeno-associated virus KW - Interleukin 10 KW - Sjogren's syndrome KW - Expression vectors KW - Interleukin 12 KW - Submandibular gland KW - Vasoactive intestinal peptide KW - xerostomia KW - beta -Galactosidase KW - Transgenes KW - RANTES KW - Keratoconjunctivitis KW - Inflammation KW - Diabetes mellitus KW - Antibodies KW - Gene transfer KW - Saliva KW - Immunosuppression KW - A 01360:Plant Diseases KW - G 07870:Mammals KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Daily+Herald&rft.atitle=St.+Charles+East+%283-0%2C+1-0%29+at+St.+Charles+North+%283-0%2C+1-0%29+Cary-Grove+%282-1%2C+2-1%29+at+Jacobs+%282-1%2C+2-1%29+Aurora+Central+Catholic+%283-0%29+at+Riverside-Brookfield+%283-0%29+Geneva+%281-2%2C+0-1%29+at+Streamwood+%281-2%2C+0-1%29+Bartlett+%282-1%2C+1-0%29+at+South+Elgin+%281-2%2C+1-0%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2016-09-16&rft.volume=&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Daily+Herald&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Serotypes; Apoptosis; beta -Galactosidase; Transgenes; Animal models; Interleukins; RANTES; Salivary gland; Immunomodulation; Keratoconjunctivitis; Interleukin 10; Inflammation; Diabetes mellitus; Expression vectors; Sjogren's syndrome; Interleukin 12; Antibodies; Gene transfer; Submandibular gland; Saliva; Vasoactive intestinal peptide; xerostomia; Immunosuppression; Adeno-associated virus ER - TY - JOUR T1 - Tetraploidy and chromosomal instability are early events during cervical carcinogenesis AN - 19837873; 6664001 AB - Chromosomal instability as manifested by increases in aneuploidy and structural chromosome aberrations is believed to play a critical role in the intermediate to late stages in the development of cervical malignancies. The current study was designed to determine the role of tetraploidy in the formation of aneuploidy and ascertain the occurrence of these alterations during the earlier stages of cervical carcinogenesis. Cervical cell samples, with diagnoses ranging from Normal to high-grade lesions, (HSIL) were obtained from 143 women and were evaluated for chromosomal alterations using dual-probe fluorescence in situ hybridization. Cervical cells from a subset of the group were also evaluated for chromosomal instability in the form of micronuclei. The frequencies of cells exhibiting either tetrasomy or aneusomy for Chromosomes 3 and 17 increased significantly with disease progression and displayed distinctive patterns where aneusomy was rarely present in the absence of tetrasomy. The frequencies of micronuclei that formed through either chromosomal loss or breakage increased significantly in both the low-grade and high-grade diagnostic categories and were highly correlated with both the number of tetrasomic and aneusomic cervical cells. In addition, a unique chromosomal alteration involving a significant non-random loss of Chromosome 17 specific to near-tetraploid aneusomic cells (trisomy 17 and tetrasomy 3) was observed. We conclude that tetraploidy and chromosomal instability are related events occurring during the early stages of cervical carcinogenesis that predispose cervical cells to the formation of aneuploidy frequently involving the loss of Chromosome 17. JF - Carcinogenesis AU - Olaharski, Andrew J AU - Sotelo, Rita AU - Solorza-Luna, Gilberto AU - Gonsebatt, Maria E AU - Guzman, Patricia AU - Mohar, Alejandro AU - Eastmond, David A AD - Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, 5429 Boyce Hall, University of California, Riverside, CA-92521, USA, Mexican National Cancer Institute, Mexico City, Mexico and Department of Genomic Medicine and Environmental Toxicology, National Autonomous University of Mexico (UNAM), Mexico City, Mexico Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 337 EP - 343 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 2 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Genetics Abstracts KW - Aneuploidy KW - Tetrasomy KW - chromosome 17 KW - Micronuclei KW - Developmental stages KW - Trisomy KW - chromosome 3 KW - Malignancy KW - Genomic instability KW - Carcinogenesis KW - Cervix KW - Chromosome aberrations KW - Tetraploidy KW - Fluorescence in situ hybridization KW - X 24490:Other KW - G 07441:Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19837873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+Finance&rft.atitle=The+Evolution+of+New+Business+in+Health+Care&rft.au=Weinberger%2C+Stanley%3BWeeks%2C+William&rft.aulast=Weinberger&rft.aufirst=Stanley&rft.date=2004-12-01&rft.volume=31&rft.issue=2&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+Finance&rft.issn=10786767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Tetrasomy; Aneuploidy; Micronuclei; chromosome 17; Developmental stages; Trisomy; chromosome 3; Malignancy; Genomic instability; Carcinogenesis; Cervix; Chromosome aberrations; Tetraploidy; Fluorescence in situ hybridization ER - TY - JOUR T1 - Molecular Structure of a 9-MDa Icosahedral Pyruvate Dehydrogenase Subcomplex Containing the E2 and E3 Enzymes Using Cryoelectron Microscopy AN - 19833665; 6713888 AB - The pyruvate dehydrogenase multienzyme complexes are among the largest multifunctional catalytic machines in cells, catalyzing the production of acetyl CoA from pyruvate. We have previously reported the molecular architecture of an 11-MDa subcomplex comprising the 60-mer icosahedral dihydrolipoyl acetyltransferase (E2) decorated with 60 copies of the heterotetrameric ( alpha sub(2) beta sub(2)) 153-kDa pyruvate decarboxylase (E1) from Bacillus stearothermophilus (Milne, J. L. S., Shi, D., Rosenthal, P. B., Sunshine, J. S., Domingo, G. J., Wu, X., Brooks, B. R., Perham, R. N., Henderson, R., and Subramaniam, S. (2002) EMBO J. 21, 5587-5598). An annular gap of similar to 90 Aa separates the acetyltransferase catalytic domains of the E2 from an outer shell formed of E1 tetramers. Using cryoelectron microscopy, we present here a three-dimensional reconstruction of the E2 core decorated with 60 copies of the homodimeric 100-kDa dihydrolipoyl dehydrogenase (E3). The E2E3 complex has a similar annular gap of similar to 75 Aa between the inner icosahedral assembly of acetyltransferase domains and the outer shell of E3 homodimers. Automated fitting of the E3 coordinates into the map suggests excellent correspondence between the density of the outer shell map and the positions of the two best fitting orientations of E3. As in the case of E1 in the E1E2 complex, the central 2-fold axis of the E3 homodimer is roughly oriented along the periphery of the shell, making the active sites of the enzyme accessible from the annular gap between the E2 core and the outer shell. The similarities in architecture of the E1E2 and E2E3 complexes indicate fundamental similarities in the mechanism of active site coupling involved in the two key stages requiring motion of the swinging lipoyl domain across the annular gap, namely the synthesis of acetyl CoA and regeneration of the dithiolane ring of the lipoyl domain. JF - Journal of Biological Chemistry AU - Milne, Jacqueline LS AU - Wu, Xiongwu AU - Borgnia, Mario J AU - Lengyel, Jeffrey S AU - Brooks, Bernard R AU - Shi, Dan AU - Perham, Richard N AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, the Laboratory of Computational Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, and the Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 4364 EP - 4370 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus stearothermophilus KW - Multienzyme complexes KW - Pyruvic acid KW - Acetyltransferase KW - Microscopy KW - Pyruvate decarboxylase KW - Enzymes KW - Shells KW - dehydrogenase KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19833665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Molecular+Structure+of+a+9-MDa+Icosahedral+Pyruvate+Dehydrogenase+Subcomplex+Containing+the+E2+and+E3+Enzymes+Using+Cryoelectron+Microscopy&rft.au=Milne%2C+Jacqueline+LS%3BWu%2C+Xiongwu%3BBorgnia%2C+Mario+J%3BLengyel%2C+Jeffrey+S%3BBrooks%2C+Bernard+R%3BShi%2C+Dan%3BPerham%2C+Richard+N%3BSubramaniam%2C+Sriram&rft.aulast=&rft.aufirst=&rft.date=2016-04-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=MENA+Report&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Multienzyme complexes; Pyruvic acid; Acetyltransferase; Pyruvate decarboxylase; Microscopy; Enzymes; Shells; dehydrogenase; Bacillus stearothermophilus ER - TY - JOUR T1 - A Randomized Phase II Study of Concurrent Docetaxel Plus Vaccine Versus Vaccine Alone in Metastatic Androgen-Independent Prostate Cancer AN - 19830171; 6717993 AB - PURPOSE: Docetaxel has activity against androgen-independent prostate cancer and preclinical studies have shown that taxane-based chemotherapy can enhance antitumor response of vaccines. The primary objective of this study was to determine if concurrent docetaxel (with dexamethasone) had any effect on generating an immune response to the vaccine. Secondary end points were whether vaccine could be given safely with docetaxel and the clinical outcome of the treatment regimen. Experimental Design: The vaccination regimen was composed of (a) recombinant vaccinia virus (rV) that expresses the prostate-specific antigen gene (rV-PSA) admixed with (b) rV that expresses the B7.1 costimulatory gene (rV-B7.1), and (c) sequential booster vaccinations with recombinant fowlpox virus (rF-) containing the PSA gene (rF-PSA). Patients received granulocyte macrophage colony-stimulating factor with each vaccination. Twenty-eight patients with metastatic androgen-independent prostate cancer were randomized to receive either vaccine and weekly docetaxel or vaccine alone. Patients on the vaccine alone arm were allowed to cross over to receive docetaxel alone at time of disease progression. The ELISPOT assay was used to monitor immune responses for PSA-specific T cells. RESULTS: The median increase in these T-cell precursors to PSA was 3.33-fold in both arms following 3 months of therapy. In addition, immune responses to other prostate cancer-associated tumor antigens were also detected postvaccination. Eleven patients who progressed on vaccine alone crossed over to receive docetaxel at time of progression. Median progression-free survival on docetaxel was 6.1 months after receiving vaccine compared with 3.7 months with the same regimen in a historical control. CONCLUSION: This is the first clinical trial to show that docetaxel can be administered safely with immunotherapy without inhibiting vaccine specific T-cell responses. Furthermore, patients previously vaccinated with an anticancer vaccine may respond longer to docetaxel compared with a historical control of patients receiving docetaxel alone. Larger prospective clinical studies will be required to validate these findings. JF - Clinical Cancer Research AU - Arlen, Philip M AU - Gulley, James L AU - Parker, Catherine AU - Skarupa, Lisa AU - Pazdur, Mary AU - Panicali, Dennis AU - Beetham, Patricia AU - Tsang, Kwong Y AU - Grosenbach, Douglas W AU - Feldman, Jarett AU - Steinberg, Seth M AU - Jones, Elizabeth AU - Chen, Clara AU - Marte, Jennifer AU - Schlom, Jeffrey AU - Dahut, William AD - Authors' Affiliations: Laboratory of Tumor Immunology and Biology, Medical Oncology Clinical Research Unit, Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, and Clinical Center, NIH, Bethesda, Maryland and Therion Biologics Corporation, Cambridge, Massachusetts Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1260 EP - 1269 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 4 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Dexamethasone KW - Enzyme-linked immunosorbent assay KW - Fowlpox KW - Immunotherapy KW - Chemotherapy KW - Granulocyte-macrophage colony-stimulating factor KW - Fowlpox virus KW - Tumors KW - prostate-specific antigen KW - Clinical trials KW - Vaccination KW - Metastases KW - Vaccinia virus KW - Prostate cancer KW - psa gene KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Immune response KW - Vaccines KW - Antitumor activity KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19830171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Randomized+Phase+II+Study+of+Concurrent+Docetaxel+Plus+Vaccine+Versus+Vaccine+Alone+in+Metastatic+Androgen-Independent+Prostate+Cancer&rft.au=Arlen%2C+Philip+M%3BGulley%2C+James+L%3BParker%2C+Catherine%3BSkarupa%2C+Lisa%3BPazdur%2C+Mary%3BPanicali%2C+Dennis%3BBeetham%2C+Patricia%3BTsang%2C+Kwong+Y%3BGrosenbach%2C+Douglas+W%3BFeldman%2C+Jarett%3BSteinberg%2C+Seth+M%3BJones%2C+Elizabeth%3BChen%2C+Clara%3BMarte%2C+Jennifer%3BSchlom%2C+Jeffrey%3BDahut%2C+William&rft.aulast=Arlen&rft.aufirst=Philip&rft.date=2006-02-01&rft.volume=12&rft.issue=4&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Enzyme-linked immunosorbent assay; Fowlpox; Chemotherapy; Immunotherapy; Granulocyte-macrophage colony-stimulating factor; Tumors; Vaccination; Clinical trials; prostate-specific antigen; Metastases; Prostate cancer; Antigen (tumor-associated); psa gene; Lymphocytes T; Vaccines; Immune response; Antitumor activity; Vaccinia virus; Fowlpox virus ER - TY - JOUR T1 - Altered Proteolysis and Global Gene Expression in Hepatitis B Virus X Transgenic Mouse Liver AN - 19827390; 6662396 AB - Hepatitis B virus X (HBX) is essential for the productive infection of hepatitis B virus (HBV) in vivo and has a pleiotropic effect on host cells. We have previously demonstrated that the proteasome complex is a cellular target of HBX, that HBX alters the proteolytic activity of proteasome in vitro, and that inhibition of proteasome leads to enhanced viral replication, suggesting that HBX and proteasome interaction plays a crucial role in the life cycle and pathogenesis of HBV. In the present study, we tested the effect of HBX on the proteasome activities in vivo in a transgenic mouse model in which HBX expression is developmentally regulated by the mouse major urinary promoter in the liver. In addition, microarray analysis was performed to examine the effect of HBX expression on the global gene expression profile of the liver. The results showed that the peptidase activities of the proteasome were reduced in the HBX transgenic mouse liver, whereas the activity of another cellular protease was elevated, suggesting a compensatory mechanism in protein degradation. In the microarray analysis, diverse genes were altered in the HBX mouse livers and the number of genes with significant changes increased progressively with age. Functional clustering showed that a number of genes involved in transcription and cell growth were significantly affected in the HBX mice, possibly accounting for the observed pleiotropic effect of HBX. In particular, insulin-like growth factor-binding protein 1 was down-regulated in the HBX mouse liver. The down-regulation was similarly observed during acute woodchuck hepatitis virus infection. Other changes including up-regulation of proteolysis-related genes may also contribute to the profound alterations of liver functions in HBV infection. JF - Journal of Virology AU - Hu, Zongyi AU - Zhang, Zhensheng AU - Kim, Jin Woo AU - Huang, Ying AU - Liang, TJake AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1405 EP - 1413 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 3 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Virology & AIDS Abstracts KW - Proteolysis KW - Insulin-like growth factor-binding protein 1 KW - Age KW - Hepatitis B virus KW - Replication KW - Animal models KW - proteasomes KW - Transcription KW - Life cycle KW - Transgenic mice KW - Infection KW - peptidase KW - DNA microarrays KW - Gene expression KW - Promoters KW - Woodchuck hepatitis virus KW - Liver KW - Proteinase KW - W 30925:Genetic Engineering KW - G 07313:Viruses KW - V 22043:Effects on host cell metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19827390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Altered+Proteolysis+and+Global+Gene+Expression+in+Hepatitis+B+Virus+X+Transgenic+Mouse+Liver&rft.au=Hu%2C+Zongyi%3BZhang%2C+Zhensheng%3BKim%2C+Jin+Woo%3BHuang%2C+Ying%3BLiang%2C+TJake&rft.aulast=Hu&rft.aufirst=Zongyi&rft.date=2006-02-01&rft.volume=80&rft.issue=3&rft.spage=1405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Age; Insulin-like growth factor-binding protein 1; Replication; proteasomes; Animal models; Life cycle; Transcription; Infection; Transgenic mice; DNA microarrays; peptidase; Gene expression; Promoters; Liver; Proteinase; Woodchuck hepatitis virus; Hepatitis B virus ER - TY - JOUR T1 - Mast cells, which interact with Escherichia coli, up-regulate genes associated with innate immunity and become less responsive to Fc epsilon RI-mediated activation AN - 19773141; 6724904 AB - Mast cells, which are associated with T helper cell type 2-dependent inflammation, have now been implicated in the innate immune response. To further characterize how mast cells are programmed to respond to infectious organisms, we used expression profiling using DNA microarray analysis of gene expression by human mast cells (huMC) during ingestion of Escherichia coli and examined immunoglobulin E (IgE)-mediated degranulation. Analysis of data revealed that specific groups of genes were modulated, including genes encoding transcription factors, cell signaling molecules, cell cycle regulators, enzymes, cytokines, novel chemokines of the CC family, adhesion molecules, and costimulatory molecules. Enzyme-linked immunosorbent assay analysis confirmed the production of tumor necrosis factor and the chemokines CC chemokine ligand (CCL)-1/I-309, CCL-19/macrophage-inflammatory protein-3 beta (MIP-3 beta ), and CCL-18/MIP-4; flow cytometry confirmed the up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1, the integrin CD49d, and CD80. Coincubation with E. coli down-regulated Fc receptor for IgE I (Fc epsilon RI) expression and Fc epsilon RI-mediated huMC degranulation. These data are consistent with the concept that bacterial exposure directs mast cell responses toward innate immunity and away from IgE-mediated effects. JF - Journal of Leukocyte Biology AU - Kulka, M AU - Fukuishi, N AU - Rottem, M AU - Mekori, YA AU - Metcalfe, D D AD - NIH/NIAID/LAD, Bldg. 10, Rm. 11C205, 10 Center Drive, MSC 1881, Bethesda, MD 20892-1881, USA, dmetcalfe@niaid.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 339 EP - 350 VL - 79 IS - 2 SN - 0741-5400, 0741-5400 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CD49d antigen KW - Chemokines KW - Helper cells KW - Tumor necrosis factor KW - Cell cycle KW - DNA microarrays KW - Flow cytometry KW - Integrins KW - Degranulation KW - Escherichia coli KW - Lymphocytes T KW - CD80 antigen KW - Cytokines KW - Enzyme-linked immunosorbent assay KW - Data processing KW - double prime Fc receptors KW - Leukocytes KW - Mast cells KW - Enzymes KW - Immunity KW - Inflammation KW - Costimulator KW - CC chemokines KW - Transcription factors KW - Immunoglobulin E KW - Immune response KW - Cell adhesion molecules KW - Signal transduction KW - F 06106:Bacteria KW - J 02350:Immunology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Mast+cells%2C+which+interact+with+Escherichia+coli%2C+up-regulate+genes+associated+with+innate+immunity+and+become+less+responsive+to+Fc+epsilon+RI-mediated+activation&rft.au=Kulka%2C+M%3BFukuishi%2C+N%3BRottem%2C+M%3BMekori%2C+YA%3BMetcalfe%2C+D+D&rft.aulast=Kulka&rft.aufirst=M&rft.date=2006-02-01&rft.volume=79&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.1004600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - CD49d antigen; Chemokines; Tumor necrosis factor; Helper cells; Cell cycle; DNA microarrays; Flow cytometry; Integrins; Degranulation; Lymphocytes T; Cytokines; CD80 antigen; Enzyme-linked immunosorbent assay; Data processing; double prime Fc receptors; Leukocytes; Enzymes; Mast cells; Immunity; Inflammation; Costimulator; CC chemokines; Immunoglobulin E; Transcription factors; Immune response; Cell adhesion molecules; Signal transduction; Escherichia coli DO - http://dx.doi.org/10.1189/jlb.1004600 ER - TY - JOUR T1 - The Multifunctional RNA-Binding Protein La Is Required for Mouse Development and for the Establishment of Embryonic Stem Cells AN - 19770455; 6664683 AB - The La protein is a target of autoantibodies in patients suffering from Sjoegren's syndrome, systemic lupus erythematosus, and neonatal lupus. Ubiquitous in eukaryotes, La functions as a RNA-binding protein that promotes the maturation of tRNA precursors and other nascent transcripts synthesized by RNA polymerase III as well as other noncoding RNAs. La also associates with a class of mRNAs that encode ribosome subunits and precursors to snoRNAs involved in ribosome biogenesis. Thus, it was surprising that La is dispensable in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the organisms from which it has been characterized most extensively. To determine whether La is essential in mammals and if so, at which developmental stage it is required, mice were created with a disrupted La gene, and the offspring from La super(+/) super(-)intercrosses were analyzed. La super(-) super(/) super(-) offspring were detected at the expected frequency among blastocysts prior to implantation, whereas no nullizygotes were detected after implantation, indicating that La is required early in development. Blastocysts derived from La super(+/) super(-) intercrosses yielded 38 La super(+/+) and La super(+/) super(-) embryonic stem (ES) cell lines but no La super(-) super(/) super(-) ES cell lines, suggesting that La contributes a critical function toward the establishment or survival of ES cells. Consistent with this, La super(-) super(/) super(-) blastocyst outgrowths revealed loss of the inner cell mass (ICM). The results indicate that in contrast to the situation in yeasts, La is essential in mammals and is one of a limited number of genes required as early as the development of the ICM. JF - Molecular and Cellular Biology AU - Park, Jung-Min AU - Kohn, Matthew J AU - Bruinsma, Monique W AU - Vech, Claire AU - Intine, Robert V AU - Fuhrmann, Stacy AU - Grinberg, Alex AU - Mukherjee, Ipsita AU - Love, Paul E AU - Ko, Minoru S AU - DePamphilis, Melvin L AU - Maraia, Richard J AD - Laboratory of Molecular Growth Regulation. Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland. Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1445 EP - 1451 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 26 IS - 4 SN - 0270-7306, 0270-7306 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell survival KW - RNA-binding protein KW - tRNA KW - La protein KW - Developmental stages KW - snoRNA KW - Ribosomes KW - double prime La protein KW - Saccharomyces cerevisiae KW - Sjogren's syndrome KW - Eukaryotes KW - DNA-directed RNA polymerase KW - blastocysts KW - Stem cells KW - Autoantibodies KW - Embryo cells KW - Embryos KW - Progeny KW - Systemic lupus erythematosus KW - Neonates KW - Evolution KW - Schizosaccharomyces pombe KW - K 03410:Animal Diseases KW - W 30940:Products KW - N 14070:Ribosomes: rRNA, ribosomal proteins, and translation KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=The+Multifunctional+RNA-Binding+Protein+La+Is+Required+for+Mouse+Development+and+for+the+Establishment+of+Embryonic+Stem+Cells&rft.au=Park%2C+Jung-Min%3BKohn%2C+Matthew+J%3BBruinsma%2C+Monique+W%3BVech%2C+Claire%3BIntine%2C+Robert+V%3BFuhrmann%2C+Stacy%3BGrinberg%2C+Alex%3BMukherjee%2C+Ipsita%3BLove%2C+Paul+E%3BKo%2C+Minoru+S%3BDePamphilis%2C+Melvin+L%3BMaraia%2C+Richard+J&rft.aulast=Park&rft.aufirst=Jung-Min&rft.date=2006-02-01&rft.volume=26&rft.issue=4&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; RNA-binding protein; tRNA; La protein; Developmental stages; double prime La protein; Ribosomes; snoRNA; Eukaryotes; Sjogren's syndrome; Stem cells; blastocysts; DNA-directed RNA polymerase; Embryo cells; Autoantibodies; Progeny; Embryos; Neonates; Systemic lupus erythematosus; Evolution; Schizosaccharomyces pombe; Saccharomyces cerevisiae ER - TY - JOUR T1 - Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid beta Peptide AN - 19768840; 6713806 AB - The human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse homologue mFPR2 mediate the chemotactic activity of a variety of polypeptides associated with inflammation and bacterial infection, including the 42-amino acid form of amyloid beta peptide (A beta sub(42)), a pathogenic factor in Alzheimer disease. Because mFPR2 was inducible in mouse microglial cells by proinflammatory stimulants, such as bacterial lipopolysaccharide, a ligand for the Toll-like receptor 4 (TLR4), we investigated the role of TLR2 in the regulation of mFPR2. We found that a TLR2 agonist, peptidoglycan (PGN) derived from Gram-positive bacterium Staphylococcus aureus, induced considerable mFpr2 mRNA expression in a mouse microglial cell line and primary microglial cells. This was associated with a markedly increased chemotaxis of the cells in response to mFPR2 agonist peptides. In addition, activation of TLR2 markedly enhanced mFPR2-mediated uptake of A beta sub(42) by microglia. Studies of the mechanistic basis showed that PGN activates MAPK and I Kappa B alpha , and the effect of PGN on induction of mFPR2 was dependent on signaling pathways via ERK1/2 and p38 MAPKs. The use of TLR2 on microglial cells by PGN was supported by the fact that N9 cells transfected with short interfering RNA targeting mouse TLR2 failed to show increased expression of functional mFPR2 after stimulation with PGN. Our results demonstrated a potentially important role for TLR2 in microglial cells of promoting cell responses to chemoattractants produced in lesions of inflammatory and neurodegenerative diseases in the brain. JF - Journal of Biological Chemistry AU - Chen, Keqiang AU - Iribarren, Pablo AU - Hu, Jinyue AU - Chen, Jianhong AU - Gong, Wanghua AU - Cho, Edward H AU - Lockett, Stephen AU - Dunlop, Nancy M AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, Image Analysis Laboratory and Basic Research Program, SAIC, NCI, National Institutes of Health, Frederick, Maryland 21702, and School of Agriculture and Biology, Shanghai Jiaotong University, 201101 Shanghai, China Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 3651 EP - 3659 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 6 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Immunology Abstracts KW - Alzheimer's disease KW - TLR2 protein KW - peptidoglycans KW - Infection KW - Chemotaxis KW - Gene expression KW - Extracellular signal-regulated kinase KW - Inflammatory diseases KW - Lipopolysaccharides KW - beta -Amyloid KW - Staphylococcus aureus KW - Microglial cells KW - TLR4 protein KW - MAP kinase KW - Brain KW - Stimulants KW - Microglia KW - Inflammation KW - Neurodegenerative diseases KW - siRNA KW - Chemotactic factors KW - formyl peptide receptor-like 1 KW - Toll-like receptors KW - Signal transduction KW - N3 11126:Alzheimer's disease and other dementias KW - N 14025:RNA/DNA role in infection & immune response KW - F 06106:Bacteria KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19768840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Activation+of+Toll-like+Receptor+2+on+Microglia+Promotes+Cell+Uptake+of+Alzheimer+Disease-associated+Amyloid+beta+Peptide&rft.au=Chen%2C+Keqiang%3BIribarren%2C+Pablo%3BHu%2C+Jinyue%3BChen%2C+Jianhong%3BGong%2C+Wanghua%3BCho%2C+Edward+H%3BLockett%2C+Stephen%3BDunlop%2C+Nancy+M%3BWang%2C+Ji+Ming&rft.aulast=Chen&rft.aufirst=Keqiang&rft.date=2006-02-01&rft.volume=281&rft.issue=6&rft.spage=3651&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - MAP kinase; TLR2 protein; Alzheimer's disease; Brain; peptidoglycans; Stimulants; Microglia; Infection; Chemotaxis; Inflammation; Gene expression; Neurodegenerative diseases; Extracellular signal-regulated kinase; Inflammatory diseases; siRNA; Chemotactic factors; formyl peptide receptor-like 1; Lipopolysaccharides; beta -Amyloid; TLR4 protein; Microglial cells; Toll-like receptors; Signal transduction; Staphylococcus aureus ER - TY - JOUR T1 - Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor- alpha and Lipopolysaccharide AN - 19733432; 6662471 AB - At the blood-brain barrier, P-glycoprotein, an ATP-driven drug efflux pump, selectively limits drug access to the brain parenchyma, impeding pharmacotherapy of a number of central nervous system (CNS) disorders. We previously used confocal imaging to demonstrate in isolated rat brain capillaries that endothelin-1 (ET-1), acting through an ET sub(B) receptor, NO synthase, and protein kinase C, rapidly and reversibly reduces P-glycoprotein transport function. In this study, we define a link between the brain's innate immune response and functional regulation of P-glycoprotein. We show that exposing brain capillaries to the inflammatory cytokine tumor necrosis factor- alpha (TNF- alpha ), activated a TNF-R1 receptor, released ET-1, activated ET sub(B) receptor signaling, and essentially abolished P-glycoprotein-mediated transport. Bacterial lipopolysaccharide, a potent activator of the brain's innate immune response, reduced P-glycoprotein activity through TNF- alpha release, ET-1 release, and ET sub(B) receptor signaling. TNF- alpha and LPS effects had a rapid onset (minutes), were reversible, and did not involve changes in tight junctional permeability. These findings define a signaling pathway through which P-glycoprotein activity is acutely modulated. They show that this key component of the selective/active blood-brain barrier is an early target of cytokine signaling during the innate immune response and suggest ways to manipulate the barrier for improved CNS pharmacotherapy. JF - Molecular Pharmacology AU - Hartz, Anika MS AU - Bauer, Bjoern AU - Fricker, Gert AU - Miller, David S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (A.M.S.H., B.B., D.S.M.) Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 462 EP - 470 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 69 IS - 2 SN - 0026-895X, 0026-895X KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Protein kinase C KW - Parenchyma KW - Protein transport KW - Central nervous system KW - Neuroimaging KW - Endothelin ETB receptors KW - Blood-brain barrier KW - Brain KW - Capillaries KW - Endothelin 1 KW - Inflammation KW - Nitric-oxide synthase KW - Permeability KW - P-Glycoprotein KW - Cytokines KW - Lipopolysaccharides KW - Immune response KW - Tumor necrosis factor- alpha KW - Drugs KW - Signal transduction KW - J 02350:Immunology KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19733432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Rapid+Modulation+of+P-Glycoprotein-Mediated+Transport+at+the+Blood-Brain+Barrier+by+Tumor+Necrosis+Factor-+alpha+and+Lipopolysaccharide&rft.au=Hartz%2C+Anika+MS%3BBauer%2C+Bjoern%3BFricker%2C+Gert%3BMiller%2C+David+S&rft.aulast=Hartz&rft.aufirst=Anika&rft.date=2006-02-01&rft.volume=69&rft.issue=2&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Parenchyma; Protein kinase C; Central nervous system; Protein transport; Neuroimaging; Endothelin ETB receptors; Blood-brain barrier; Brain; Capillaries; Endothelin 1; Inflammation; Nitric-oxide synthase; Permeability; P-Glycoprotein; Lipopolysaccharides; Cytokines; Tumor necrosis factor- alpha; Immune response; Drugs; Signal transduction ER - TY - JOUR T1 - Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years AN - 19692665; 7451891 AB - Background Data from several studies indicate that children of mothers who smoked during pregnancy may be at a risk of overweight compared with children of non-smoking mothers. The size of this relation, however, is unclear, as is the age at which it becomes detectable. Methods Prospective data for 34 866 children enrolled in the US Collaborative Perinatal Project were analysed to examine maternal pregnancy smoking in relation to weight, height, and body mass index (BMI) in offspring at ages 1, 3, 4, 7, and 8 years. Results Compared with offspring of non-smokers, children of smokers had (i) weight that was lower at birth but then quickly equalled or exceeded that of non-smokers, (ii) consistently decreased height, and (iii) increased risk of overweight, particularly in girls. For example, at age 7 years, the adjusted odds ratio of BMI greater than or equal to 85th percentile in boys of mothers who smoked on an average greater than or equal to 20 cigarettes per day while pregnant was 1.22 (95% confidence interval 1.03-1.46), and in girls it was 1.30 (1.08-1.56). Conclusions In these data, maternal smoking during pregnancy was associated with a modest increase in risk of overweight in children before the age of 8 years. JF - International Journal of Epidemiology AU - Chen, A AU - Pennell, M L AU - Klebanoff, MA AU - Rogan, W J AU - Longnecker, M P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Mail Drop A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA, chen17@niehs.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 121 EP - 130 VL - 35 IS - 1 SN - 0300-5771, 0300-5771 KW - Physical Education Index KW - Obesity KW - Age KW - Boys KW - Body mass KW - Height KW - Children KW - Pregnancy KW - Smoking KW - Weight KW - Epidemiology KW - Girls KW - Tobacco KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19692665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Maternal+smoking+during+pregnancy+in+relation+to+child+overweight%3A+follow-up+to+age+8+years&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1999-10-23&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toronto+Star&rft.issn=03190781&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smoking; Obesity; Age; Epidemiology; Weight; Boys; Body mass; Girls; Tobacco; Height; Children; Pregnancy DO - http://dx.doi.org/10.1093/ije/dyi218 ER - TY - JOUR T1 - Ambient BTEX and MTBE in the neighborhoods of different industrial parks in Southern Taiwan AN - 19672296; 6681070 AB - This study assessed the concentrations of five volatile organic compounds (VOCs), including BTEX (the acronym for benzene, toluene, ethylbenzene, and xylene) and methyl tertiary-butyl ether (MTBE), in six different industrial park neighborhoods in southern Taiwan, including the Nei-Pu, Ping-Tung, Ping- Nan, Ren-Wu, Lin-Yuan and Nan-Zi industrial parks. The concentrations of MTBE and BTEX ranged from undetectable to 145.6 mu g/m super(3). Average MTBE-BTEX ratios of Nei-Pu, Ping-Tung, Ping-Nan, Ren-Wu, Lin-Yuan and Nan-Zi were (13.4:3.6:4.7:1.0:7.4), (2.9:1.0:1.7:1.3:2.9), (3.0:1.0:2.7:1.0:2.7), (5.2:1.0:8.6:1.7:4.9), (3.1:3.1:2.8:1.0:3.3) and (4.3:1.2:3.6:1.0:3.8), respectively. Moreover, average T/B ratios in Nei-Pu, Ping-Tung, Ping-Nan, Ren- Wu, Lin-Yuan and Nan-Zi were 1.3, 1.7, 2.6, 8.6, 0.9 and 2.9, respectively. High T/B ratio (8.6) in the neighborhood of the Ren-Wu industrial park suggested that the emission of large additional sources of toluene from this industrial park, or the existence of major differences in the auxiliary fuels used. Average X/E ratios in Nei-Pu, Ping-Tung, Ping-Nan, Ren-Wu, Lin-Yuan and Nan-Zi were 7.4, 2.2, 2.7, 2.9, 3.3 and 3.8, respectively. The lower X/E ratio (2.2) in the Ping- Tung neighborhood compared to elsewhere indicates an aged air parcel. Furthermore, principal component analysis also confirmed that the dominant influences in the six different industrial park neighborhoods were related to the emissions of MTBE, benzene and toluene. JF - Journal of Hazardous Materials AU - Hsieh, Lien-Te AU - Yang, Hsi-Hsien AU - Chen, Ho-Wen AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu 912, Ping Tung 91201, Taiwan, Lthsieh@mail.npust.edu.tw Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 106 EP - 115 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 128 IS - 2-3 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - MTBE KW - BTEX KW - Industrial park neighborhood KW - T/B ratio KW - X/E ratio KW - Taiwan KW - Toluene KW - Fuels KW - Benzene KW - Xylene KW - Principal components analysis KW - Residential areas KW - Parks KW - volatile organic compounds KW - Ethers KW - Ethylbenzene KW - Industrial emissions KW - Volatile organic compounds KW - H 3000:Environment and Ecology KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19672296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Ambient+BTEX+and+MTBE+in+the+neighborhoods+of+different+industrial+parks+in+Southern+Taiwan&rft.au=Hsieh%2C+Lien-Te%3BYang%2C+Hsi-Hsien%3BChen%2C+Ho-Wen&rft.aulast=Hsieh&rft.aufirst=Lien-Te&rft.date=2006-02-01&rft.volume=128&rft.issue=2-3&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2005.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Xylene; Fuels; Principal components analysis; Toluene; MTBE; volatile organic compounds; Parks; Ethylbenzene; Ethers; Benzene; Residential areas; Volatile organic compounds; Industrial emissions; Taiwan DO - http://dx.doi.org/10.1016/j.jhazmat.2005.08.001 ER - TY - JOUR T1 - Characterization of Adrenal Adenomas and Metastases: Correlation between Unenhanced Computed Tomography and Chemical Shift Magnetic Resonance Imaging AN - 19613987; 7331475 AB - Purpose: To evaluate the correlation of absolute attenuation values of unenhanced computed tomography (CT) with signal intensity (SI) quantitative analysis on chemical shift (CS) magnetic resonance (MR) imaging in differentiating adrenal adenomas from metastases. Material and Methods: Forty- one adrenal masses (27 adenomas, 14 metastases) were studied with CS MR imaging and unenhanced CT. MR included T1-weighted breathhold gradient-echo in-phase (IP) and opposed-phase (OP) sequences. The SI index (SI-i) [(SI IP -SI OP /SI IP )]x100% and chemical-shift ratio (CS-r) relative to the spleen [(SI lesion /SI spleen )OP/(SI lesion /SI spleen )IP] were calculated for each lesion. CT absolute attenuation values were also determined. Results: The mean attenuation value of metastases was significantly greater than that of adenomas ( P -0.0001) and no overlaps were evident. The CS-r of malignant and benign lesions overlapped considerably, and five adenomas (all with indeterminate Hounsfield Unit values at CT) were misclassified as potentially malignant. CT attenuation values were significantly correlated with both MR quantitative analyses. Conclusion: Since CS MR imaging and CT both depict the presence of lipids within adrenal lesions, absolute attenuation values are highly correlated with MR quantitative analysis. SI-i is the most reliable tool for differentiating adrenal adenomas from metastases, showing better accuracy than lesion-to-spleen CS-r, in particular for adenomas with indeterminate absolute attenuation values. JF - Acta Radiologica AU - Rescinito, G AU - Zandrino, F AU - Cittadini, G AU - Santacroce, E AU - Giasotto, V AU - Neumaier, CE AD - Department of Diagnostic Imaging, National Cancer Institute, Genoa, Italy; Department of Diagnostic Imaging and Interventional Radiology, Alessandria, Italy; Department of Radiology, University of Genoa, Genoa, Italy Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 71 EP - 76 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 47 IS - 1 SN - 0284-1851, 0284-1851 KW - Biotechnology and Bioengineering Abstracts KW - Adrenal mass KW - computed tomography (CT) KW - magnetic resonance (MR) KW - chemical shift imaging KW - Metastases KW - Lipids KW - Computed tomography KW - Magnetic resonance imaging KW - Spleen KW - Adenoma KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Radiologica&rft.atitle=Characterization+of+Adrenal+Adenomas+and+Metastases%3A+Correlation+between+Unenhanced+Computed+Tomography+and+Chemical+Shift+Magnetic+Resonance+Imaging&rft.au=Rescinito%2C+G%3BZandrino%2C+F%3BCittadini%2C+G%3BSantacroce%2C+E%3BGiasotto%2C+V%3BNeumaier%2C+CE&rft.aulast=Rescinito&rft.aufirst=G&rft.date=2006-02-01&rft.volume=47&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Acta+Radiologica&rft.issn=02841851&rft_id=info:doi/10.1080%2F02841850500405193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; Lipids; Magnetic resonance imaging; Computed tomography; Spleen; Adenoma DO - http://dx.doi.org/10.1080/02841850500405193 ER - TY - JOUR T1 - Development of small molecules designed to modulate protein-protein interactions AN - 19494038; 7187717 AB - Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Developing small molecules that modulate protein-protein interactions is challenging, owing to the large size of protein-complex interface, the lack of well-defined binding pockets, etc. We describe a general approach based on the 'privileged-structure hypothesis' [Che, Ph.D. Thesis, Washington University, 2003] - that any organic templates capable of mimicking surfaces of protein-recognition motifs are potential privileged scaffolds as protein-complex antagonists - to address the challenges inherent in the discovery of small-molecule inhibitors of protein-protein interactions. JF - Journal of Computer-Aided Molecular Design AU - Che, Ye AU - Brooks, Bernard R AU - Marshall, Garland R AD - National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA, chey@nhlbi.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 109 EP - 130 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 20 IS - 2 SN - 0920-654X, 0920-654X KW - Biotechnology and Bioengineering Abstracts KW - Mimicry KW - Antagonists KW - scaffolds KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19494038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computer-Aided+Molecular+Design&rft.atitle=Development+of+small+molecules+designed+to+modulate+protein-protein+interactions&rft.au=Che%2C+Ye%3BBrooks%2C+Bernard+R%3BMarshall%2C+Garland+R&rft.aulast=Che&rft.aufirst=Ye&rft.date=2006-02-01&rft.volume=20&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computer-Aided+Molecular+Design&rft.issn=0920654X&rft_id=info:doi/10.1007%2Fs10822-006-9040-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Protein interaction; scaffolds; Antagonists; Mimicry DO - http://dx.doi.org/10.1007/s10822-006-9040-8 ER - TY - JOUR T1 - Detectability Decreases With Off-Normal Viewing in Medical Liquid Crystal Displays AN - 19483626; 7185037 AB - To quantify the reduction in detection performance of subtle signals at off-normal viewing directions in medical active-matrix liquid crystal displays (AMLCDs). Fifty synthetic image pairs per viewing condition (a total of 350) were used in a two-alternative forced-choice experiment in which 11 trained observers viewed images at 0, 30, and 45 degrees from the display normal, along the diagonal axis of a 5 million pixel in-plane switching monochrome AMLCD. The images were generated using white-noise backgrounds. A Gaussian signal was added to the signal-present set with three different signal amplitudes (4, 8, and 12 gray levels in a 10-bit scale). The average percent correct achieved for a signal of 4 gray levels was 79.6 (95% confidence intervals based on reader and case variability: 71.686.9), 63.4 (CI 56.071.3), and 55.3 (CI 48.462.0), for 0, 30 and 45 degrees from the display normal, respectively. When the signal amplitude was increased by a factor of two, the performance was 76.9 and 57.0 for 30 and 45 degrees, respectively, and 95.3 and 85.3 when the amplitude was increased by a factor of three. The observers took on average about twice as long and as much as seven times as long to reach decisions in off-normal viewing. Off-normal viewing of diagnostic images in AMLCDs significantly reduces the detection of low-contrast abnormalities. Increased off-normal signal amplitudes were required to regain the detection performance measured for normal viewing. We observed this decrease in detection performance for off-normal viewing even when measured decision times were about twice as long as for normal viewing. JF - Academic Radiology AU - Badano, A AU - Gallas, B D AD - NIBIB/CDRH Laboratory for the Assessment of Medical Imaging, Center for Devices and Radiological Health, Food and Drug Administration, 12720 Twinbrook Parkway, HFZ-142, Rockville, MD 20857 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 210 EP - 218 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 2 SN - 1076-6332, 1076-6332 KW - Biotechnology and Bioengineering Abstracts KW - Gaussian signals KW - Crystals KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19483626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+Radiology&rft.atitle=Detectability+Decreases+With+Off-Normal+Viewing+in+Medical+Liquid+Crystal+Displays&rft.au=Badano%2C+A%3BGallas%2C+B+D&rft.aulast=Badano&rft.aufirst=A&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Academic+Radiology&rft.issn=10766332&rft_id=info:doi/10.1016%2Fj.acra.2005.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Crystals; Gaussian signals DO - http://dx.doi.org/10.1016/j.acra.2005.08.015 ER - TY - JOUR T1 - Transcending the biomarker mindset: deciphering disease mechanisms at the single cell level AN - 19442145; 6757871 AB - The application of proteomics to disease research promises to enhance the understanding and treatment of many human maladies through the identification of molecular profiles associated with each disease. However, although much is made of the utility of molecular signatures as markers of disease state, insufficient emphasis is often placed on the simultaneous need for biological mechanism inquiry. Focused and detailed analyses of disease-associated signaling networks have the potential to be more mechanistically informative than large-scale proteomic profiling approaches, providing insight into the cellular processes involved in pathogenesis, disease progression and therapeutic resistance; while still providing diagnostic or clinical management direction. Phospho-specific flow cytometry provides a method for the analysis of pathological signaling networks, enabling the investigation of disease mechanisms at the single-cell level. JF - Current Opinion in Chemical Biology AU - Danna, E A AU - Nolan, G P AD - Stanford NHLBI Proteomics Center, Baxter Laboratory of Genetic Pharmacology, Department of Microbiology and Immunology, School of Medicine, Stanford University, 269 Campus Drive, CCSR 3205, Stanford, CA 94305, USA, gnolan@stanford.edu Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 20 EP - 27 VL - 10 IS - 1 SN - 1367-5931, 1367-5931 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Reviews KW - proteomics KW - biomarkers KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Chemical+Biology&rft.atitle=Transcending+the+biomarker+mindset%3A+deciphering+disease+mechanisms+at+the+single+cell+level&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Hotline.+National+Journal%27s+Daily+Briefing+on+Politics+%28Online%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Signal transduction; proteomics; Flow cytometry; Reviews; biomarkers DO - http://dx.doi.org/10.1016/j.cbpa.2005.12.021 ER - TY - JOUR T1 - PAGE: phase-shifted analysis of gene expression AN - 19439962; 6666435 AB - SUMMARY: Grouping of gene expression patterns across biological experiments, treatments and time-series data is performed in q-intervals of measurements using phase-shifted analysis of gene expression (PAGE); a Java-based tool to find clusters of genes that share trends of expression profiles within the dataset. The patterns and genes within q-Clusters are visualized in trend plots and compared to determine biological relevance from the gene annotations. AVAILABILITY: PAGE is available at http://dir.niehs.nih.gov/microarray/software/page/. Supplementary information: The Supplementary data are available at http://dir.niehs.nih.gov/microarray/software/page/ JF - Bioinformatics AU - Leung, Elo AU - Bushel, Pierre R AD - Bioinformatics and Computational Biology, School of Computational Sciences, George Mason University Manassas, VA 20110, USA. National Institute of Environmental Health Sciences, National Center for Toxicogenomics, Microarray Group, Research Triangle Park NC 27709, USA, bushel@niehs.nih.gov Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 367 EP - 368 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 3 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Data processing KW - Bioinformatics KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=PAGE%3A+phase-shifted+analysis+of+gene+expression&rft.au=Leung%2C+Elo%3BBushel%2C+Pierre+R&rft.aulast=Leung&rft.aufirst=Elo&rft.date=2006-02-01&rft.volume=22&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Data processing; Bioinformatics ER - TY - JOUR T1 - A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities AN - 19433560; 6718530 AB - We discovered a thalidomide analogue [5-hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33)] with antiproliferative activity against nine cancer cell lines in vitro. Flow cytometric analyses showed that the compound caused G sub(2)-M arrest, which occurred mainly at the mitotic phase. In addition, immunofluorescence microscopy and in vitro tubulin polymerization studies showed that 5HPP-33 has antimicrotubule activity with a paclitaxel-like mode of action. It is effective against four different paclitaxel-resistant cell lines. Thus, 5HPP-33 represents a potential antitumor agent. [Mol Cancer Ther 2006; 5(2):450-6] JF - Molecular Cancer Therapeutics AU - Li, Pui-Kai AU - Pandit, Bulbul AU - Sackett, Dan L AU - Hu, Zhigen AU - Zink, Jennifer AU - Zhi, Jiandong AU - Freeman, Dena AU - Robey, Robert W AU - Werbovetz, Karl AU - Lewis, Andrew AU - Li, Chenglong AD - Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio and Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 450 EP - 456 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 5 IS - 2 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Tumor cell lines KW - Polymerization KW - Thalidomide KW - Immunofluorescence KW - Tubulin KW - Antitumor agents KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19433560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=A+thalidomide+analogue+with+in+vitro+antiproliferative%2C+antimitotic%2C+and+microtubule-stabilizing+activities&rft.au=Li%2C+Pui-Kai%3BPandit%2C+Bulbul%3BSackett%2C+Dan+L%3BHu%2C+Zhigen%3BZink%2C+Jennifer%3BZhi%2C+Jiandong%3BFreeman%2C+Dena%3BRobey%2C+Robert+W%3BWerbovetz%2C+Karl%3BLewis%2C+Andrew%3BLi%2C+Chenglong&rft.aulast=Li&rft.aufirst=Pui-Kai&rft.date=2006-02-01&rft.volume=5&rft.issue=2&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Thalidomide; Cancer; Flow cytometry; Tumor cell lines; Immunofluorescence; Antitumor agents; Tubulin; Polymerization ER - TY - JOUR T1 - An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks AN - 19432485; 6719579 AB - Over 8000 expressed sequence tags from six different salivary gland cDNA libraries from the tick Ixodes scapularis were analyzed. These libraries derive from feeding nymphs infected or not with the Lyme disease agent, Borrelia burgdorferi, from unfed adults, and from adults feeding on a rabbit for 6-12h, 18-24h, and 3-4 days. Comparisons of the several libraries led to identification of several significantly differentially expressed transcripts. Additionally, over 500 new predicted protein sequences are described, including several novel gene families unique to ticks; no function can be presently ascribed to most of these novel families. Among the housekeeping-associated transcripts, we highlight those enzymes associated with post translation modification of amino acids, particularly those forming sulfotyrosine, hydroxyproline, and carboxyl-glutamic acid. Results support the hypothesis that gene duplication, most possibly including genome duplications, is a major player in tick evolution. electrophoresis JF - Insect Biochemistry and Molecular Biology AU - Ribeiro, JMC AU - Alarcon-Chaidez, F AU - B Francischetti, IM AU - Mans, B J AU - Mather, T N AU - Valenzuela, J G AU - Wikel, S K AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, jribeiro@niaid.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 111 EP - 129 PB - Elsevier Ltd VL - 36 IS - 2 SN - 0965-1748, 0965-1748 KW - Deer tick KW - Ticks KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - Genomes KW - Translation KW - Feeding KW - Hydroxyproline KW - Electrophoresis KW - Amino acids KW - Catalogs KW - Borrelia burgdorferi KW - Ixodidae KW - Enzymes KW - Ixodes scapularis KW - Gene families KW - Salivary gland KW - expressed sequence tags KW - gene duplication KW - Evolution KW - Lyme disease KW - Z 05206:Medical & veterinary entomology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19432485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=An+annotated+catalog+of+salivary+gland+transcripts+from+Ixodes+scapularis+ticks&rft.au=Ribeiro%2C+JMC%3BAlarcon-Chaidez%2C+F%3BB+Francischetti%2C+IM%3BMans%2C+B+J%3BMather%2C+T+N%3BValenzuela%2C+J+G%3BWikel%2C+S+K&rft.aulast=Ribeiro&rft.aufirst=JMC&rft.date=2006-02-01&rft.volume=36&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2005.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Feeding; Translation; Hydroxyproline; Catalogs; Amino acids; Electrophoresis; Enzymes; Salivary gland; Gene families; expressed sequence tags; gene duplication; Evolution; Lyme disease; Borrelia burgdorferi; Ixodidae; Ixodes scapularis DO - http://dx.doi.org/10.1016/j.ibmb.2005.11.005 ER - TY - JOUR T1 - Transfer and multiplex immunoblotting of a paraffin embedded tissue AN - 19427910; 6691281 AB - As we transition from genomics to the challenges of the functional proteome, new tools to explore the expression of proteins within tissue are essential. We have developed a method of transferring proteins from a formalin fixed, paraffin embedded tissues section to a stack of membranes which is then probed with antibodies for detection of individual epitopes. This method converts a traditional tissue section into a multiplex platform for expression profiling. A single tissue section can be transferred to up to ten membranes, each of which is probed with different antibodies, and detected with fluorescent secondary antibodies, and quantified by a microarray scanner. Total protein can be determined on each membrane, hence each antibody has its own normalization. This method works with phospho-specific antibodies as well as antibodies that do not readily work well with paraffin embedded tissue. This novel technique enables archival paraffin embedded tissue to be molecularly profiled in a rapid and quantifiable manner, and reduces the tissue microarray to a form of protein array. This method is a new tool for exploration of the vast archive of formalin fixed, paraffin embedded tissue, as well as a tool for translational medicine. JF - Proteomics AU - Chung, Joon-Yong AU - Braunschweig, Till AU - Baibakov, Galina AU - Galperin, Mike AU - Ramesh, Arun AU - Skacel, Marek AU - Gannot, Gallya AU - Knezevic, Vladimir AU - Hewitt, Stephen M AD - Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, genejock@helix.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 767 EP - 774 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 6 IS - 3 SN - 1615-9853, 1615-9853 KW - Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Translation KW - Paraffin KW - Antibodies KW - Protein arrays KW - Formaldehyde KW - proteomics KW - genomics KW - Epitopes KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19427910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Globe+and+Mail&rft.atitle=Average+monthly+public+service+salaries+in+selected+occupations+at+July+1&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1982-10-01&rft.volume=&rft.issue=&rft.spage=R.2&rft.isbn=&rft.btitle=&rft.title=The+Globe+and+Mail&rft.issn=03190714&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antibodies; Paraffin; Formaldehyde; Translation; genomics; Immunoblotting; proteomics; Epitopes; Protein arrays DO - http://dx.doi.org/10.1002/pmic.200401343 ER - TY - JOUR T1 - Cancer Screening and Risk Factor Rates Among American Indians AN - 19426880; 6663431 AB - OBJECTIVES: We examined cancer screening and risk factor patterns in California using 4 different statistical tabulations of American Indian and Alaska Native (AIAN) populations. METHODS: We used the 2001 California Health Interview Survey to compare cancer screening and risk factor data across 4 different tabulation approaches. We calculated weighted prevalence estimates by gender and race/ethnicity for cancer screening and risk factors, sociodemographic characteristics, and access to care variables. We compared AIAN men and women with members of other racial groups and examined outcomes among AIAN men and women using the 4 tabulation methods. RESULTS: Although some differences were small, in general, screening and risk factor rates among American Indians/Alaska Natives were most similar to rates among Whites when the most inclusive multiracial tabulation approach was used and least similar when the more exclusive US census "single-race" approach was used. CONCLUSIONS: Racial misclassification and undercounting are among the most difficult obstacles to obtaining accurate and informative data on the AIAN population. Our analysis suggests some guidelines for overcoming these obstacles. JF - American Journal of Public Health AU - Swan, Judith AU - Breen, Nancy AU - Burhansstipanov, Linda AU - Satter, Delight E AU - Davis, William W AU - McNeel, Timothy AU - Snipp, CMatthew AD - Surveillance Research Program, Division of Cancer Control and a Population Sciences, National Cancer Institute, Bethesda, MD Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 340 EP - 350 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 2 SN - 0090-0036, 0090-0036 KW - Native Americans KW - Sustainability Science Abstracts; Risk Abstracts KW - Guidelines KW - Surveys KW - INE, USA, Alaska KW - Cancer KW - Public health KW - INE, USA, California KW - Risk factors KW - Genetic screening KW - Census KW - USA, California KW - Ethnic groups KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19426880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Cancer+Screening+and+Risk+Factor+Rates+Among+American+Indians&rft.au=Swan%2C+Judith%3BBreen%2C+Nancy%3BBurhansstipanov%2C+Linda%3BSatter%2C+Delight+E%3BDavis%2C+William+W%3BMcNeel%2C+Timothy%3BSnipp%2C+CMatthew&rft.aulast=Swan&rft.aufirst=Judith&rft.date=2006-02-01&rft.volume=96&rft.issue=2&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk factors; Guidelines; Surveys; Genetic screening; Census; Cancer; Public health; Ethnic groups; INE, USA, California; INE, USA, Alaska; USA, California ER - TY - JOUR T1 - Nonisotopic detection of microRNA using digoxigenin labeled RNA probes AN - 19423894; 6686965 AB - MicroRNAs (miRNAs) are an important class of endogenously derived, small 22 nucleotide noncoding regulatory RNAs that have recently become implicated in development, cell regulation and cancers of various tissues. Here we report a nonisotopic Northern analysis method for miRNA detection using 3'-digoxigenin (DIG)-labeled RNA oligo probes. Northern blot analysis was performed using miRNA or total RNA fractions extracted from human leukemic cell lines, and blots were hybridized with either super(32)P- or DIG-labeled RNA probe for miR-181, miR-155 or miR-16. A labeled probe for U6 small nuclear RNA served as an internal control. The use of DIG-labeled RNA probes was equally sensitive compared to super(32)P- labeled probes in detecting miRNA quantities as low as 50 ng. The ability to use nonisotopic methods and yet obtain sensitive and reliable results offers an advantage to investigators who prefer to avoid isotopes. JF - Molecular and Cellular Probes AU - Ramkissoon, Shakti H AU - Mainwaring, Lori A AU - Sloand, Elaine M AU - Young, Neal S AU - Kajigaya, Sachiko AD - Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Bethesda, MD, USA, kajigays@mail.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1 EP - 4 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 20 IS - 1 SN - 0890-8508, 0890-8508 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - microRNA KW - RNA oligonucleotide probe KW - Northern analysis KW - DIG KW - snRNA KW - Leukemia KW - Isotopes KW - RNA probes KW - DNA probes KW - Digoxigenin KW - miRNA KW - Nucleotides KW - Cancer KW - N 14830:RNA KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19423894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Nonisotopic+detection+of+microRNA+using+digoxigenin+labeled+RNA+probes&rft.au=Ramkissoon%2C+Shakti+H%3BMainwaring%2C+Lori+A%3BSloand%2C+Elaine+M%3BYoung%2C+Neal+S%3BKajigaya%2C+Sachiko&rft.aulast=Ramkissoon&rft.aufirst=Shakti&rft.date=2006-02-01&rft.volume=20&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2005.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Leukemia; snRNA; Isotopes; RNA probes; Digoxigenin; DNA probes; miRNA; Cancer; Nucleotides DO - http://dx.doi.org/10.1016/j.mcp.2005.07.004 ER - TY - JOUR T1 - Nicotine as a typical drug of abuse in experimental animals and humans AN - 19284520; 7025264 AB - Rationale and background: Tobacco use through cigarette smoking is the leading preventable cause of death in the developed world. Nicotine, a psychoactive component of tobacco, appears to play a major role in tobacco dependence, but reinforcing effects of nicotine often are difficult to demonstrate directly in controlled laboratory studies with animal or human subjects. Objective: To review the major findings obtained with various procedures developed to study dependence-related behavioral effects of nicotine in experimental animals and humans, i.e., drug self-administration, conditioned place preference, subjective reports of nicotine effects and nicotine discrimination, withdrawal signs, and ratings of drug withdrawal. Results: Nicotine can function as an effective reinforcer of drug-seeking and drug-taking behavior both in experimental animals and humans under appropriate conditions. Interruption of chronic nicotine exposure produces withdrawal symptoms that may contribute to relapse. Difficulties encountered in demonstrating reinforcing effects of nicotine under some conditions, relative to other drugs of abuse, may be due to weaker primary reinforcing effects of nicotine or to a more critical contribution of environmental stimuli to the maintenance of drug-seeking and drug-taking behavior with nicotine than with other drugs of abuse. Further experiments are also needed to delineate the role other chemical substances inhaled along with nicotine in tobacco smoke play in sustaining smoking behavior. Conclusion: Nicotine acts as a typical drug of abuse in experimental animals and humans. JF - Psychopharmacology AU - Foll, Bernard AU - Goldberg, Steven R AD - Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA, blefoll@intra.nida.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 367 EP - 381 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 184 IS - 3-4 SN - 0033-3158, 0033-3158 KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Smoke KW - Place preferences KW - Nicotine KW - Withdrawal KW - Reviews KW - Cigarette smoking KW - Tobacco KW - Reinforcement KW - Environmental effects KW - Drug abuse KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Nicotine+as+a+typical+drug+of+abuse+in+experimental+animals+and+humans&rft.au=Foll%2C+Bernard%3BGoldberg%2C+Steven+R&rft.aulast=Foll&rft.aufirst=Bernard&rft.date=2006-02-01&rft.volume=184&rft.issue=3-4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-005-0155-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoke; Place preferences; Nicotine; Reviews; Withdrawal; Cigarette smoking; Environmental effects; Reinforcement; Tobacco; Drug abuse; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-005-0155-8 ER - TY - JOUR T1 - Differential strength of association of child injury prevention attitudes and beliefs on practices: a case for audience segmentation AN - 17481742; 6666257 AB - OBJECTIVE: Many injuries to children cannot be prevented without some degree of active behavior on the part of parents. A better understanding of social and cognitive determinants of parents' injury prevention behavior and the identification of potential subgroups for targeted message delivery could advance the effectiveness of educational and behavioral interventions. This study assessed the degree to which parents' injury prevention behavior is associated with theoretical determinants and examined whether this relation differs by age or birth order of child. DESIGN: Cross sectional observational study. SETTING: Three Midwestern pediatric clinics. SUBJECTS: 594 parents of children ages 0-4 attending routine well child visits. MEASURES: Injury prevention attitudes, beliefs, and practices. RESULTS: Overall, only modest relations were observed between injury beliefs and attitudes and injury prevention behaviors. However, these relations differed substantially by child age and birth order, with stronger associations observed for parents of older first born children. Outcome expectations and social norms were more strongly related to injury prevention behavior among parents of preschool children than among parents of infants and toddlers, while attitudes were more predictive for parents of first born children than parents of later born children. CONCLUSIONS: These findings highlight the complexity of relations between theorized determinants and behavior, and suggest the potential utility of using audience segmentation strategies in behavioral interventions addressing injury prevention. JF - Injury Prevention AU - Vladutiu, C J AU - Nansel, T R AU - Weaver, N L AU - Jacobsen, H A AU - Kreuter, M W AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services. Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services. Health Communication Research Laboratory Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 35 EP - 40 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 12 IS - 1 SN - 1353-8047, 1353-8047 KW - parental supervision KW - Physical Education Index; Health & Safety Science Abstracts KW - Age KW - Injuries KW - Pediatrics KW - Preventive health KW - Strategy KW - Preschool children KW - Intervention KW - Health (behavior) KW - Children KW - Birth order KW - Prevention KW - Attitudes KW - Behavior KW - Standards KW - Human factors KW - Parents KW - Infants KW - H 11000:Diseases/Injuries/Trauma KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17481742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Differential+strength+of+association+of+child+injury+prevention+attitudes+and+beliefs+on+practices%3A+a+case+for+audience+segmentation&rft.au=Vladutiu%2C+C+J%3BNansel%2C+T+R%3BWeaver%2C+N+L%3BJacobsen%2C+H+A%3BKreuter%2C+M+W&rft.aulast=Vladutiu&rft.aufirst=C&rft.date=2006-02-01&rft.volume=12&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Injuries; Preventive health; Pediatrics; Strategy; Health (behavior); Intervention; Preschool children; Children; Birth order; Attitudes; Standards; Parents; Prevention; Behavior; Human factors; Infants ER - TY - JOUR T1 - Characterization of Late Acyltransferase Genes of Yersinia pestis and Their Role in Temperature-Dependent Lipid A Variation AN - 17477603; 6661008 AB - Yersinia pestis is an important human pathogen that is maintained in flea-rodent enzootic cycles in many parts of the world. During its life cycle, Y. pestis senses host-specific environmental cues such as temperature and regulates gene expression appropriately to adapt to the insect or mammalian host. For example, Y. pestis synthesizes different forms of lipid A when grown at temperatures corresponding to the in vivo environments of the mammalian host and the flea vector. At 37 degree C, tetra-acylated lipid A is the major form; but at 26 degree C or below, hexa-acylated lipid A predominates. In this study, we show that the Y. pestis msbB (lpxM) and lpxP homologs encode the acyltransferases that add C sub(12) and C sub(16:1) groups, respectively, to lipid IV sub(A) to generate the hexa-acylated form, and that their expression is upregulated at 21 degree C in vitro and in the flea midgut. A Y. pestis Delta msbB Delta lpxP double mutant that did not produce hexa-acylated lipid A was more sensitive to cecropin A, but not to polymyxin B. This mutant was able to infect and block fleas as well as the parental wild-type strain, indicating that the low-temperature-dependent change to hexa-acylated lipid A synthesis is not required for survival in the flea gut. JF - Journal of Bacteriology AU - Rebeil, Roberto AU - Ernst, Robert K AU - Jarrett, Clayton O AU - Adams, Kristin N AU - Miller, Samuel I AU - Hinnebusch, BJoseph AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Departments of Medicine. Microbiology. Genome Sciences, University of Washington, Seattle, Washington 98195 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1381 EP - 1388 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 4 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Lipids KW - Yersinia pestis KW - Survival KW - Life cycle KW - Pathogens KW - polymyxin B KW - Cecropin KW - Digestive tract KW - Acyltransferase KW - Lipid A KW - Midgut KW - G 07320:Bacterial genetics KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17477603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Characterization+of+Late+Acyltransferase+Genes+of+Yersinia+pestis+and+Their+Role+in+Temperature-Dependent+Lipid+A+Variation&rft.au=Rebeil%2C+Roberto%3BErnst%2C+Robert+K%3BJarrett%2C+Clayton+O%3BAdams%2C+Kristin+N%3BMiller%2C+Samuel+I%3BHinnebusch%2C+BJoseph&rft.aulast=Rebeil&rft.aufirst=Roberto&rft.date=2006-02-01&rft.volume=188&rft.issue=4&rft.spage=1381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cecropin; Digestive tract; Acyltransferase; Lipids; Life cycle; Survival; Lipid A; polymyxin B; Midgut; Pathogens; Yersinia pestis ER - TY - JOUR T1 - Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris AN - 17477054; 6672929 AB - Production of recombinant malaria proteins in the methylotrophic yeast Pichia pastoris has been difficult due to constraints in transcription, translation and/or post-translation controls. Use of codon-optimized genes has resolved many of the transcriptional controls; however, efforts to overcome translational and post-translational modifications involving disulfide bond formation and glycosylation have been mostly restricted to knocking-out putative N-linked glycosylation sites. We report now on the effect of overproduction of P. pastoris protein disulfide isomerase (PpPDI) and Plasmodium falciparum (PfPDI) on production of a disulfide-rich P. falciparum transmission-blocking vaccine candidate, Pfs25. Pfs25 is expressed in P. pastoris as two isoforms (A and B); the A form has been selected for Phase I human studies. Overproduction of PpPDI in the P. pastoris Pfs25 production clone markedly enhanced the expression level of Pfs25(A) and (B) by 3-fold, while overproduction of PfPDI increased the proportion of Pfs25(A) compared to (B). The resultant Pfs25 products were purified and fully characterized biochemically. In addition to differences in production levels, the mass spectra of PpPDI-Pfs25(A) compared to Pfs25(A) and PfPDI-Pfs25(A) were different due to the pattern and level of O-linked glycosylation. The overproduction of PpPDI or PfPDI provides new platforms for expression of disulfide-rich malaria proteins. JF - Journal of Biotechnology AU - Tsai, Chiawei W AU - Duggan, Peter F AU - Shimp, Richard L AU - Miller, Louis H AU - Narum, David L AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, dnarum@niaid.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 458 EP - 470 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 121 IS - 4 SN - 0168-1656, 0168-1656 KW - disulfide isomerase KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Translation KW - Transcription KW - Malaria KW - Glycosylation KW - Plasmodium falciparum KW - Protein folding KW - Post-translation KW - Vaccines KW - Pichia pastoris KW - W3 33365:Vaccines (other) KW - K 03086:Immunology & vaccination KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17477054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biotechnology&rft.atitle=Overproduction+of+Pichia+pastoris+or+Plasmodium+falciparum+protein+disulfide+isomerase+affects+expression%2C+folding+and+O-linked+glycosylation+of+a+malaria+vaccine+candidate+expressed+in+P.+pastoris&rft.au=Tsai%2C+Chiawei+W%3BDuggan%2C+Peter+F%3BShimp%2C+Richard+L%3BMiller%2C+Louis+H%3BNarum%2C+David+L&rft.aulast=Tsai&rft.aufirst=Chiawei&rft.date=2006-02-01&rft.volume=121&rft.issue=4&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biotechnology&rft.issn=01681656&rft_id=info:doi/10.1016%2Fj.jbiotec.2005.08.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Plasmodium falciparum; Pichia pastoris; Glycosylation; Malaria; Translation; Transcription; Vaccines; Post-translation; Protein folding DO - http://dx.doi.org/10.1016/j.jbiotec.2005.08.025 ER - TY - JOUR T1 - The Bacteriophage T4 Inhibitor and Coactivator AsiA Inhibits Escherichia coli RNA Polymerase More Rapidly in the Absence of sigma super(70) Region 1.1: Evidence that Region 1.1 Stabilizes the Interaction between sigma super(70) and Core AN - 17476309; 6660997 AB - The N-terminal region (region 1.1) of sigma super(70), the primary sigma subunit of Escherichia coli RNA polymerase, is a negatively charged domain that affects the DNA binding properties of sigma super(70) regions 2 and 4. Region 1.1 prevents the interaction of free sigma super(70) with DNA and modulates the formation of stable (open) polymerase/promoter complexes at certain promoters. The bacteriophage T4 AsiA protein is an inhibitor of sigma super(70)-dependent transcription from promoters that require an interaction between sigma super(70) region 4 and the -35 DNA element and is the coactivator of transcription at T4 MotA-dependent promoters. Like AsiA, the T4 activator MotA also interacts with sigma super(70) region 4. We have investigated the effect of region 1.1 on AsiA inhibition and MotA/AsiA activation. We show that sigma super(70) region 1.1 is not required for MotA/AsiA activation at the T4 middle promoter P sub(uvsX). However, the rate of AsiA inhibition and of MotA/AsiA activation of polymerase is significantly increased when region 1.1 is missing. We also find that RNA polymerase reconstituted with sigma super(70) that lacks region 1.1 is less stable than polymerase with full-length sigma super(70). Our previous work has demonstrated that the AsiA-inhibited polymerase is formed when AsiA binds to region 4 of free sigma super(70) and then the AsiA/ sigma super(70) complex binds to core. Our results suggest that in the absence of region 1.1, there is a shift in the dynamic equilibrium between polymerase holoenzyme and free sigma super(70) plus core, yielding more free sigma super(70) at any given time. Thus, the rate of AsiA inhibition and AsiA/MotA activation increases when RNA polymerase lacks region 1.1 because of the increased availability of free sigma super(70). Previous work has argued both for and against a direct interaction between regions 1.1 and 4. Using an E. coli two-hybrid assay, we do not detect an interaction between these regions. This result supports the idea that the ability of region 1.1 to prevent DNA binding by free sigma super(70) arises through an indirect effect. JF - Journal of Bacteriology AU - Hinton, Deborah M AU - Vuthoori, Srilatha AU - Mulamba, Rebecca AD - Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8 Room 2A-13, Bethesda, Maryland 20892-0830 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1279 EP - 1285 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 4 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Phages KW - Promoters KW - sigma 70 Factor KW - DNA-directed RNA polymerase KW - Cores KW - AsiA protein KW - Escherichia coli KW - DNA KW - Transcription KW - MotA protein KW - J 02750:Phage-host interactions KW - N 14090:RNA: Ribozymes, Ribonucleoproteins, RNA-binding protein KW - V 22070:Phage-host interactions including lysogeny & transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17476309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Bacteriophage+T4+Inhibitor+and+Coactivator+AsiA+Inhibits+Escherichia+coli+RNA+Polymerase+More+Rapidly+in+the+Absence+of+sigma+super%2870%29+Region+1.1%3A+Evidence+that+Region+1.1+Stabilizes+the+Interaction+between+sigma+super%2870%29+and+Core&rft.au=Hinton%2C+Deborah+M%3BVuthoori%2C+Srilatha%3BMulamba%2C+Rebecca&rft.aulast=Hinton&rft.aufirst=Deborah&rft.date=2006-02-01&rft.volume=188&rft.issue=4&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Promoters; DNA-directed RNA polymerase; sigma 70 Factor; Cores; AsiA protein; DNA; Transcription; MotA protein; Escherichia coli ER - TY - JOUR T1 - Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens AN - 17473047; 6662064 AB - Anthrax edema toxin (EdTx) is an AB-type toxin that binds to anthrax toxin receptors on target cells via the binding subunit, protective Ag (PA). Edema factor, the enzymatic A subunit of EdTx, is an adenylate cyclase. We found that nasal delivery of EdTx enhanced systemic immunity to nasally coadministered OVA and resulted in high OVA-specific plasma IgA and IgG (mainly IgG1 and IgG2b). The edema factor also enhanced immunity to the binding PA subunit itself and promoted high levels of plasma IgG and IgA responses as well as neutralizing PA Abs. Mice given OVA and EdTx also exhibited both PA- and OVA-specific IgA and IgG Ab responses in saliva as well as IgA Ab responses in vaginal washes. EdTx as adjuvant triggered OVA- and PA-specific CD4 super(+) T cells which secreted IFN- gamma and selected Th2-type cytokines. The EdTx up-regulated costimulatory molecule expression by APCs but was less effective than cholera toxin for inducing IL-6 responses either by APCs in vitro or in nasal washes in vivo. Finally, nasally administered EdTx did not target CNS tissues and did not induce IL-1 mRNA responses in the nasopharyngeal-associated lymphoepithelial tissue or in the olfactory bulb epithelium. Thus, EdTx derivatives could represent an alternative to the ganglioside-binding enterotoxin adjuvants and provide new tools for inducing protective immunity to PA-based anthrax vaccines. JF - Journal of Immunology AU - Duverger, Alexandra AU - Jackson, Raymond J AU - van Ginkel, Frederick W AU - Fischer, Romy AU - Tafaro, Angela AU - Leppla, Stephen H AU - Fujihashi, Kohtaro AU - Kiyono, Hiroshi AU - McGhee, Jerry R AU - Boyaka, Prosper N AD - Department of Microbiology and Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294. Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1776 EP - 1783 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 3 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Medical and Pharmaceutical Biotechnology Abstracts KW - Interleukin 6 KW - gamma -Interferon KW - Ovalbumin KW - Central nervous system KW - Interleukin 1 KW - Edema KW - Adjuvants KW - Bacillus anthracis KW - Olfactory bulb KW - CD4 antigen KW - Antigens KW - Intranasal administration KW - Cholera toxin KW - Lymphocytes T KW - Anthrax KW - Epithelium KW - Antigen-presenting cells KW - Adenylate cyclase KW - Mucosal immunity KW - Immunity KW - mRNA KW - Costimulator KW - Immunoglobulin A KW - Vagina KW - Immunoglobulin G KW - Enterotoxins KW - Immune response KW - Saliva KW - Vaccines KW - W3 33365:Vaccines (other) KW - J 02834:Vaccination and immunization KW - X 24370:Natural Toxins KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17473047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Bacillus+anthracis+Edema+Toxin+Acts+as+an+Adjuvant+for+Mucosal+Immune+Responses+to+Nasally+Administered+Vaccine+Antigens&rft.au=Duverger%2C+Alexandra%3BJackson%2C+Raymond+J%3Bvan+Ginkel%2C+Frederick+W%3BFischer%2C+Romy%3BTafaro%2C+Angela%3BLeppla%2C+Stephen+H%3BFujihashi%2C+Kohtaro%3BKiyono%2C+Hiroshi%3BMcGhee%2C+Jerry+R%3BBoyaka%2C+Prosper+N&rft.aulast=Duverger&rft.aufirst=Alexandra&rft.date=2006-02-01&rft.volume=176&rft.issue=3&rft.spage=1776&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Central nervous system; Ovalbumin; gamma -Interferon; Interleukin 1; Edema; Adjuvants; Olfactory bulb; CD4 antigen; Intranasal administration; Antigens; Cholera toxin; Lymphocytes T; Anthrax; Epithelium; Antigen-presenting cells; Adenylate cyclase; Mucosal immunity; Immunity; mRNA; Costimulator; Immunoglobulin A; Vagina; Immunoglobulin G; Enterotoxins; Vaccines; Saliva; Immune response; Bacillus anthracis ER - TY - JOUR T1 - CCL5 Modulates Pneumococcal Immunity and Carriage AN - 17470041; 6662126 AB - Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases. We show that CCL5, together with Th cytokine mRNA expression, is temporally up-regulated during pneumococcal carriage. To determine the contribution of CCL5 to pneumococcal surface antigen A-specific humoral and cellular pneumococcal immunity, mice were treated with anti-CCL5 or control Abs before and during Streptococcus pneumoniae strain EF3030-challenge for the initiation of carriage. CCL5 blockade resulted in a decrease of CD4 super(+) and CD8 super(+) T cells as well as CD11b super(+) cells in the spleen, cervical lymph node, lung, and nasopharyngeal associated lymphoid tissue during the recognition phase of the pneumococcal adaptive immune response. CCL5 blockade significantly reduced the Ag-specific IgG2a and IgG1 Abs in serum and IgA Ab levels in nasal washes. These decreases also corresponded to reductions in Ag-specific T cell (mucosal and systemic) responses. CCL5 inhibition resulted in decreasing the quantity of IL-4- and IFN- gamma -secreting CD4 super(+) T cells and increasing the number of Ag-specific IL-10-producing CD4 super(+) T cells; these changes combined also corresponded with the transition from pneumococcal carriage to lethal pneumonia. These data suggest that CCL5 is an essential factor for the induction and maintenance of protective pneumococcal immunity. JF - Journal of Immunology AU - Palaniappan, Ravichandran AU - Singh, Shailesh AU - Singh, Udai P AU - Singh, Rajesh AU - Ades, Edwin W AU - Briles, David E AU - Hollingshead, Susan K AU - Royal, Walter III AU - Sampson, Jacquelyn S AU - Stiles, Jonathan K AU - Taub, Dennis D AU - Lillard, James WJr AD - Mercer University, Atlanta GA 30341. Morehouse School of Medicine, Atlanta, GA 30310. Centers for Disease Control and Prevention, Atlanta, GA 30333. University of Alabama at Birmingham, Birmingham, AL 35294. National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 2346 EP - 2356 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 4 SN - 0022-1767, 0022-1767 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Gene polymorphism KW - Spleen KW - CD8 antigen KW - Gene expression KW - Streptococcus pneumoniae KW - CD4 antigen KW - Infectious diseases KW - Lung KW - Lymphocytes T KW - Immunoglobulin G KW - Cytokines KW - Pneumonia KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17470041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CCL5+Modulates+Pneumococcal+Immunity+and+Carriage&rft.au=Palaniappan%2C+Ravichandran%3BSingh%2C+Shailesh%3BSingh%2C+Udai+P%3BSingh%2C+Rajesh%3BAdes%2C+Edwin+W%3BBriles%2C+David+E%3BHollingshead%2C+Susan+K%3BRoyal%2C+Walter+III%3BSampson%2C+Jacquelyn+S%3BStiles%2C+Jonathan+K%3BTaub%2C+Dennis+D%3BLillard%2C+James+WJr&rft.aulast=Palaniappan&rft.aufirst=Ravichandran&rft.date=2006-02-01&rft.volume=176&rft.issue=4&rft.spage=2346&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; gamma -Interferon; CD4 antigen; Infectious diseases; Lung; Gene polymorphism; Immunoglobulin G; Lymphocytes T; Cytokines; Spleen; CD8 antigen; Pneumonia; Streptococcus pneumoniae ER - TY - JOUR T1 - Segregation of the Replication Terminus of the Two Vibrio cholerae Chromosomes AN - 17469038; 6660948 AB - Genome duplication and segregation normally are completed before cell division in all organisms. The temporal relation of duplication and segregation, however, can vary in bacteria. Chromosomal regions can segregate towards opposite poles as they are replicated or can stay cohered for a considerable period before segregation. The bacterium Vibrio cholerae has two differently sized circular chromosomes, chromosome I (chrI) and chrII, of about 3 and 1 Mbp, respectively. The two chromosomes initiate replication synchronously, and the shorter chrII is expected to complete replication earlier than the longer chrI. A question arises as to whether the segregation of chrII also is completed before that of chrI. We fluorescently labeled the terminus regions of chrI and chrII and followed their movements during the bacterial cell cycle. The chrI terminus behaved similarly to that of the Escherichia coli chromosome in that it segregated at the very end of the cell division cycle: cells showed a single fluorescent focus even when the division septum was nearly complete. In contrast, the single focus representing the chrII terminus could divide at the midcell position well before cell septation was conspicuous. There were also cells where the single focus for chrII lingered at midcell until the end of a division cycle, like the terminus of chrI. The single focus in these cells overlapped with the terminus focus for chrI in all cases. It appears that there could be coordination between the two chromosomes through the replication and/or segregation of the terminus region to ensure their segregation to daughter cells. JF - Journal of Bacteriology AU - Srivastava, Preeti AU - Fekete, Richard A AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892-4255 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1060 EP - 1070 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 3 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Vibrio cholerae KW - Chromosomes KW - Cell division KW - chromosome I KW - Replication KW - Cell cycle KW - Escherichia coli KW - Septation KW - Septum KW - J 02721:Cell cycle, morphology and motility KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17469038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Segregation+of+the+Replication+Terminus+of+the+Two+Vibrio+cholerae+Chromosomes&rft.au=Srivastava%2C+Preeti%3BFekete%2C+Richard+A%3BChattoraj%2C+Dhruba+K&rft.aulast=Srivastava&rft.aufirst=Preeti&rft.date=2006-02-01&rft.volume=188&rft.issue=3&rft.spage=1060&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Cell division; Chromosomes; chromosome I; Replication; Cell cycle; Septation; Septum; Vibrio cholerae; Escherichia coli ER - TY - JOUR T1 - Serotype Differences and Lack of Biofilm Formation Characterize Yersinia pseudotuberculosis Infection of the Xenopsylla cheopis Flea Vector of Yersinia pestis AN - 17467996; 6660953 AB - Yersinia pestis, the agent of plague, is usually transmitted by fleas. To produce a transmissible infection, Y. pestis colonizes the flea midgut and forms a biofilm in the proventricular valve, which blocks normal blood feeding. The enteropathogen Yersinia pseudotuberculosis, from which Y. pestis recently evolved, is not transmitted by fleas. However, both Y. pestis and Y. pseudotuberculosis form biofilms that adhere to the external mouthparts and block feeding of Caenorhabditis elegans nematodes, which has been proposed as a model of Y. pestis-flea interactions. We compared the ability of Y. pestis and Y. pseudotuberculosis to infect the rat flea Xenopsylla cheopis and to produce biofilms in the flea and in vitro. Five of 18 Y. pseudotuberculosis strains, encompassing seven serotypes, including all three serotype O3 strains tested, were unable to stably colonize the flea midgut. The other strains persisted in the flea midgut for 4 weeks but did not increase in numbers, and none of the 18 strains colonized the proventriculus or produced a biofilm in the flea. Y. pseudotuberculosis strains also varied greatly in their ability to produce biofilms in vitro, but there was no correlation between biofilm phenotype in vitro or on the surface of C. elegans and the ability to colonize or block fleas. Our results support a model in which a genetic change in the Y. pseudotuberculosis progenitor of Y. pestis extended its pre-existing ex vivo biofilm-forming ability to the flea gut environment, thus enabling proventricular blockage and efficient flea-borne transmission. JF - Journal of Bacteriology AU - Erickson, David L AU - Jarrett, Clayton O AU - Wren, Brendan W AU - Hinnebusch, BJoseph AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana. London School of Hygiene and Tropical Medicine, London, United Kingdom Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1113 EP - 1119 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 3 SN - 0021-9193, 0021-9193 KW - Oriental rat flea KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Feeding KW - Serotypes KW - Yersinia pestis KW - Yersinia pseudotuberculosis KW - Infection KW - Xenopsylla cheopis KW - Blood KW - Digestive tract KW - Host-pathogen interactions KW - Caenorhabditis elegans KW - Biofilms KW - Midgut KW - Plague KW - Pseudotuberculosis KW - G 07320:Bacterial genetics KW - J 02710:Identification, taxonomy and typing KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Serotype+Differences+and+Lack+of+Biofilm+Formation+Characterize+Yersinia+pseudotuberculosis+Infection+of+the+Xenopsylla+cheopis+Flea+Vector+of+Yersinia+pestis&rft.au=Erickson%2C+David+L%3BJarrett%2C+Clayton+O%3BWren%2C+Brendan+W%3BHinnebusch%2C+BJoseph&rft.aulast=Erickson&rft.aufirst=David&rft.date=2006-02-01&rft.volume=188&rft.issue=3&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Blood; Feeding; Digestive tract; Serotypes; Host-pathogen interactions; Plague; Midgut; Biofilms; Infection; Pseudotuberculosis; Xenopsylla cheopis; Caenorhabditis elegans; Yersinia pseudotuberculosis; Yersinia pestis ER - TY - JOUR T1 - Discovering Clinical Biomarkers of Ionizing Radiation Exposure with Serum Proteomic Analysis AN - 17467204; 6660468 AB - In this study, we sought to explore the merit of proteomic profiling strategies in patients with cancer before and during radiotherapy in an effort to discover clinical biomarkers of radiation exposure. Patients with a diagnosis of cancer provided informed consent for enrollment on a study permitting the collection of serum immediately before and during a course of radiation therapy. High-resolution surface-enhanced laser desorption and ionization-time of flight (SELDI-TOF) mass spectrometry (MS) was used to generate high-throughput proteomic profiles of unfractionated serum samples using an immobilized metal ion-affinity chromatography nickel-affinity chip surface. Resultant proteomic profiles were analyzed for unique biomarker signatures using supervised classification techniques. MS-based protein identification was then done on pooled sera in an effort to begin to identify specific protein fragments that are altered with radiation exposure. Sixty-eight patients with a wide range of diagnoses and radiation treatment plans provided serum samples both before and during ionizing radiation exposure. Computer-based analyses of the SELDI protein spectra could distinguish unexposed from radiation-exposed patient samples with 91% to 100% sensitivity and 97% to 100% specificity using various classifier models. The method also showed an ability to distinguish high from low dose-volume levels of exposure with a sensitivity of 83% to 100% and specificity of 91% to 100%. Using direct identity techniques of albumin-bound peptides, known to underpin the SELDI-TOF fingerprints, 23 protein fragments/peptides were uniquely detected in the radiation exposure group, including an interleukin-6 precursor protein. The composition of proteins in serum seems to change with ionizing radiation exposure. Proteomic analysis for the discovery of clinical biomarkers of radiation exposure warrants further study. JF - Cancer Research AU - Menard, Cynthia AU - Johann, Donald AU - Lowenthal, Mark AU - Muanza, Thierry AU - Sproull, Mary AU - Ross, Sally AU - Gulley, James AU - Petricoin, Emanuel AU - Coleman, CNorman AU - Whiteley, Gordon AU - Liotta, Lance AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1844 EP - 1850 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 3 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Affinity chromatography KW - Interleukin 6 KW - Metals KW - ^a Radiation KW - Ionizing radiation KW - Radiotherapy KW - Lasers KW - proteomics KW - biomarkers KW - Mass spectroscopy KW - Cancer KW - W 30965:Miscellaneous, Reviews KW - W3 33130:Genetic based (PCR, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Discovering+Clinical+Biomarkers+of+Ionizing+Radiation+Exposure+with+Serum+Proteomic+Analysis&rft.au=Menard%2C+Cynthia%3BJohann%2C+Donald%3BLowenthal%2C+Mark%3BMuanza%2C+Thierry%3BSproull%2C+Mary%3BRoss%2C+Sally%3BGulley%2C+James%3BPetricoin%2C+Emanuel%3BColeman%2C+CNorman%3BWhiteley%2C+Gordon%3BLiotta%2C+Lance%3BCamphausen%2C+Kevin&rft.aulast=Menard&rft.aufirst=Cynthia&rft.date=2006-02-01&rft.volume=66&rft.issue=3&rft.spage=1844&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; biomarkers; Ionizing radiation; Cancer; ^a Radiation; Metals; Mass spectroscopy; Interleukin 6; Lasers; Affinity chromatography; Radiotherapy ER - TY - JOUR T1 - Transcriptome Analysis Applied to Survival of Shewanella oneidensis MR-1 Exposed to Ionizing Radiation AN - 17460668; 6660967 AB - The ionizing radiation (IR) dose that yields 20% survival (D sub(20)) of Shewanella oneidensis MR-1 is lower by factors of 20 and 200 than those for Escherichia coli and Deinococcus radiodurans, respectively. Transcriptome analysis was used to identify the genes of MR-1 responding to 40 Gy (D sub(20)). We observed the induction of 170 genes and repression of 87 genes in MR-1 during a 1-h recovery period after irradiation. The genomic response of MR-1 to IR is very similar to its response to UV radiation (254 nm), which included induction of systems involved in DNA repair and prophage synthesis and the absence of differential regulation of tricarboxylic acid cycle activity, which occurs in IR-irradiated D. radiodurans. Furthermore, strong induction of genes encoding antioxidant enzymes in MR-1 was observed. DNA damage may not be the principal cause of high sensitivity to IR, considering that MR-1 carries genes encoding a complex set of DNA repair systems and 40 Gy IR induces less than one double-strand break in its genome. Instead, a combination of oxidative stress, protein damage, and prophage-mediated cell lysis during irradiation and recovery might underlie this organism's great sensitivity to IR. JF - Journal of Bacteriology AU - Qiu, Xiaoyun AU - Daly, Michael J AU - Vasilenko, Alexander AU - Omelchenko, Marina V AU - Gaidamakova, Elena K AU - Wu, Liyou AU - Zhou, Jizhong AU - Sundin, George W AU - Tiedje, James M AD - Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824. Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. National Institutes of Health, Bethesda, Maryland 20894. Environmental Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831. Department of Plant Pathology, Michigan State University, East Lansing, Michigan 48824 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1199 EP - 1204 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 3 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Antioxidants KW - Survival KW - Double-strand break repair KW - DNA repair KW - Prophages KW - DNA damage KW - U.V. radiation KW - Radiation KW - Oxidative stress KW - Ionizing radiation KW - Shewanella oneidensis KW - Escherichia coli KW - Deinococcus radiodurans KW - Tricarboxylic acid cycle KW - Gene silencing KW - N 14030:DNA: biosynthesis, repair & replication cycle KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17460668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Transcriptome+Analysis+Applied+to+Survival+of+Shewanella+oneidensis+MR-1+Exposed+to+Ionizing+Radiation&rft.au=Qiu%2C+Xiaoyun%3BDaly%2C+Michael+J%3BVasilenko%2C+Alexander%3BOmelchenko%2C+Marina+V%3BGaidamakova%2C+Elena+K%3BWu%2C+Liyou%3BZhou%2C+Jizhong%3BSundin%2C+George+W%3BTiedje%2C+James+M&rft.aulast=Qiu&rft.aufirst=Xiaoyun&rft.date=2006-02-01&rft.volume=188&rft.issue=3&rft.spage=1199&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Antioxidants; Survival; DNA repair; Double-strand break repair; Prophages; DNA damage; U.V. radiation; Radiation; Oxidative stress; Ionizing radiation; Tricarboxylic acid cycle; Gene silencing; Shewanella oneidensis; Escherichia coli; Deinococcus radiodurans ER - TY - JOUR T1 - Mutator mutants of Escherichia coli carrying a defect in the DNA polymerase III tau subunit AN - 17125095; 6630567 AB - To investigate the possible role of accessory subunits of Escherichia coli DNA polymerase III holoenzyme (HE) in determining chromosomal replication fidelity, we have investigated the role of the dnaX gene. This gene encodes both the tau and gamma subunits of HE, which play a central role in the organization and functioning of HE at the replication fork. We find that a classical, temperature-sensitive dnaX allele, dnaX36, displays a pronounced mutator effect, characterized by an unusual specificity: preferential enhancement of transversions and -1 frameshifts. The latter occur predominantly at non-run sequences. The dnaX36 defect does not affect the gamma subunit, but produces a tau subunit carrying a missense substitution (E601K) in its C-terminal domain (domain V) that is involved in interaction with the Pol III alpha subunit. A search for new mutators in the dnaX region of the chromosome yielded six additional dnaX mutators, all carrying a specific tau subunit defect. The new mutators displayed phenotypes similar to dnaX36: strong enhancement of transversions and frameshifts and only weak enhancement for transitions. The combined findings suggest that the tau subunit of HE plays an important role in determining the fidelity of the chromosomal replication, specifically in the avoidance of transversions and frameshift mutations. JF - Molecular Microbiology AU - Pham, Phuong T AU - Zhao, Wei AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, schaaper@niehs.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1149 EP - 1161 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 4 SN - 0950-382X, 0950-382X KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Fidelity KW - Chromosomes KW - Frameshift mutation KW - Replication forks KW - Replication KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Transversion KW - G 07320:Bacterial genetics KW - N 14835:Protein-Nucleic Acids Association KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17125095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Mutator+mutants+of+Escherichia+coli+carrying+a+defect+in+the+DNA+polymerase+III+tau+subunit&rft.au=Pham%2C+Phuong+T%3BZhao%2C+Wei%3BSchaaper%2C+Roel+M&rft.aulast=Pham&rft.aufirst=Phuong&rft.date=2006-02-01&rft.volume=59&rft.issue=4&rft.spage=1149&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.05011.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - SuppNotes - Figures, 3; tables, 7; references, 65. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; Fidelity; Replication forks; Frameshift mutation; Replication; DNA-directed DNA polymerase; Transversion; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2005.05011.x ER - TY - JOUR T1 - Genomics update: Protecting sausages with bacteria instead of salt AN - 17122805; 6586929 JF - Environmental Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 185 EP - 192 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 8 IS - 2 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salts KW - Food KW - Sausages KW - Protection KW - genomics KW - A 01019:Sterilization, preservation & packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17122805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Genomics+update%3A+Protecting+sausages+with+bacteria+instead+of+salt&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-02-01&rft.volume=8&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2005.00985.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - SuppNotes - Tables, 1; references, 34. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salts; Protection; Food; Sausages; genomics DO - http://dx.doi.org/10.1111/j.1462-2920.2005.00985.x ER - TY - JOUR T1 - Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 17095111; 6717826 AB - Energy restriction remains one of the most effective ways known to prevent breast cancer in animal models. However, energy intake has not been consistently associated with risk of breast cancer in humans. In a prospective study, we assessed whether energy intake, body size, and physical activity each independently influence breast cancer risk in postmenopausal women and estimated the joint effect of combinations of these individual factors. As part of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, 38,660 women, ages 55 to 74 years and recruited from 10 centers in the United States during 1993 to 2001, were randomized to the screening arm of the trial. At baseline, the women completed a self-administered questionnaire, including a food frequency questionnaire. During follow-up from 1993 to 2003, 764 incident breast cancer cases were ascertained. Women in the highest quartile of energy intake ( greater than or equal to 2,084 kcal/d) compared with those in the lowest quartile (30 kg/m super(2) with <22.5 kg/m super(2), 1.35; 95% CI, 1.06-1.70; P sub(trend) = 0.01). Women with greater than or equal to 4 hours/wk of vigorous recreational physical activity had a significantly reduced risk of breast cancer compared with those who reported no recreational physical activity (multivariate RR, 0.78; 95% CI, 0.60-0.99; P sub(trend) = 0.15). None of these associations with individual energy balance measures was substantially confounded by the other two measures. When we estimated the joint effect of all three variables, women with the most unfavorable energy balance (the highest energy intake, highest BMI, and least physical activity) had twice the risk (RR, 2.10; 95% CI, 1.27-3.45) of women with the most favorable energy balance (the lowest energy intake, lowest BMI, and most physical activity). Although our estimates of absolute energy intake, based on a food frequency questionnaire, are imperfect, these results suggest that energy intake, in addition to BMI and physical activity may be independently associated with breast cancer risk. In addition, these three aspects of energy balance may act jointly in determining breast cancer risk. (Cancer Epidemiol Prev 2006; 15(2):334-41) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chang, Shih-Chen AU - Ziegler, Regina G AU - Dunn, Barbara AU - Stolzenberg-Solomon, Rachael AU - Lacey, James VJr AU - Huang, Wen-Yi AU - Schatzkin, Arthur AU - Reding, Douglas AU - Hoover, Robert N AU - Hartge, Patricia AU - Leitzmann, Michael F AD - Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland and Marshfield Medical Research and Education Foundation, Marshfield, Minnesota Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 334 EP - 341 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 2 SN - 1055-9965, 1055-9965 KW - Physical Education Index; Oncogenes & Growth Factors Abstracts KW - Risk assessment KW - Food KW - Physical activity KW - Body mass KW - Women KW - Energy intake KW - Animal models KW - Breasts KW - Post-menopause KW - Body size KW - Ovarian cancer KW - Inventories KW - Dietary restrictions KW - Preventive health KW - Surveys KW - Exercise KW - Cancer KW - Joints KW - Energy balance KW - Epidemiology KW - Breast cancer KW - Lungs KW - Diet KW - Body mass index KW - Prostate KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17095111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Association+of+Energy+Intake+and+Energy+Balance+with+Postmenopausal+Breast+Cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Chang%2C+Shih-Chen%3BZiegler%2C+Regina+G%3BDunn%2C+Barbara%3BStolzenberg-Solomon%2C+Rachael%3BLacey%2C+James+VJr%3BHuang%2C+Wen-Yi%3BSchatzkin%2C+Arthur%3BReding%2C+Douglas%3BHoover%2C+Robert+N%3BHartge%2C+Patricia%3BLeitzmann%2C+Michael+F&rft.aulast=Chang&rft.aufirst=Shih-Chen&rft.date=2006-02-01&rft.volume=15&rft.issue=2&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epidemiology; Preventive health; Body mass; Women; Lungs; Surveys; Breasts; Diet; Exercise; Cancer; Joints; Risk assessment; Inventories; Ovarian cancer; Dietary restrictions; Physical activity; Food; Animal models; Energy intake; Energy balance; Post-menopause; Body size; Breast cancer; Body mass index; Prostate ER - TY - JOUR T1 - Supplemental and Dietary Vitamin E, beta -Carotene, and Vitamin C Intakes and Prostate Cancer Risk AN - 17089493; 6715295 AB - BACKGROUND: Vitamin E, beta -carotene, and vitamin C are micronutrient antioxidants that protect cells from oxidative damage involved in prostate carcinogenesis. In separate trials, supplemental vitamin E was associated with a decreased risk of prostate cancer among smokers and supplemental beta -carotene was associated with a decreased risk of prostate cancer among men with low baseline plasma beta -carotene levels. METHODS: We evaluated the association between intake of these micronutrient antioxidants from foods and supplements and the risk of prostate cancer among men in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. At baseline, trial participants completed a 137-item food frequency questionnaire that included detailed questions on 12 individual supplements. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS: We identified 1338 cases of prostate cancer among 29 361 men during up to 8 years of follow-up. Overall, there was no association between prostate cancer risk and dietary or supplemental intake of vitamin E, beta -carotene, or vitamin C. However, among current and recent (i.e., within the previous 10 years) smokers, decreasing risks of advanced prostate cancer (i.e., Gleason score greater than or equal to 7 or stage III or IV) were associated with increasing dose (RR for >400 IU/day versus none = 0.29, 95% CI = 0.12 to 0.68; P sub(trend) = .01) and duration (RR for greater than or equal to 10 years of use versus none = 0.30, 95% CI = 0.09 to 0.96; P sub(trend) = .01) of supplemental vitamin E use. Supplemental beta -carotene intake at a dose level of at least 2000 mu g/day was associated with decreased prostate cancer risk in men with low (below the median of 4129 mu g/day) dietary beta -carotene intake (RR = 0.52, 95% CI = 0.33 to 0.81). Among smokers, the age-adjusted rate of advanced prostate cancer was 492 per 100 000 person-years in those who did not take supplemental vitamin E, 153 per 100 000 person-years in those who took more than 400 IU/day of supplemental vitamin E, and 157 per 100 000 person-years in those who took supplemental vitamin E for 10 or more years. Among men with low dietary beta -carotene intake, the age-adjusted rate of prostate cancer was 1122 per 100 000 person-years in those who did not take supplemental beta -carotene, and 623 per 100 000 person-years in those who took at least 2000 mu g/day of supplemental beta -carotene. CONCLUSIONS: Our results do not provide strong support for population-wide implementation of high-dose antioxidant supplementation for the prevention of prostate cancer. However, vitamin E supplementation in male smokers and beta -carotene supplementation in men with low dietary beta -carotene intakes were associated with reduced risk of this disease. JF - Journal of the National Cancer Institute AU - Kirsh, Victoria A AU - Hayes, Richard B AU - Mayne, Susan T AU - Chatterjee, Nilanjan AU - Subar, Amy F AU - Dixon, LBeth AU - Albanes, Demetrius AU - Andriole, Gerald L AU - Urban, Donald A AU - Peters, Ulrike AD - Division of Cancer Epidemiology and Genetics (VAK, RBH, NC, DA, UP), Division of Cancer Control and Population Sciences (AFS), National Cancer Institute, NIH, DHHS, Bethesda, MD Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 245 EP - 254 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 4 SN - 0027-8874, 0027-8874 KW - prostate KW - Risk Abstracts KW - Diets KW - Antioxidants KW - Risk reduction KW - Nutrition KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17089493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Supplemental+and+Dietary+Vitamin+E%2C+beta+-Carotene%2C+and+Vitamin+C+Intakes+and+Prostate+Cancer+Risk&rft.au=Kirsh%2C+Victoria+A%3BHayes%2C+Richard+B%3BMayne%2C+Susan+T%3BChatterjee%2C+Nilanjan%3BSubar%2C+Amy+F%3BDixon%2C+LBeth%3BAlbanes%2C+Demetrius%3BAndriole%2C+Gerald+L%3BUrban%2C+Donald+A%3BPeters%2C+Ulrike&rft.aulast=Kirsh&rft.aufirst=Victoria&rft.date=2006-02-01&rft.volume=98&rft.issue=4&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Antioxidants; Risk reduction; Nutrition; Cancer ER - TY - JOUR T1 - Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome AN - 17086767; 6715242 AB - Children with Hutchinson-Gilford progeria syndrome (HGPS) suffer from dramatic acceleration of some symptoms associated with normal aging, most notably cardiovascular disease that eventually leads to death from myocardial infarction and/or stroke usually in their second decade of life. For the vast majority of cases, a de novo point mutation in the lamin A (LMNA) gene is the cause of HGPS. This missense mutation creates a cryptic splice donor site that produces a mutant lamin A protein, termed "progerin," which carries a 50-aa deletion near its C terminus. We have created a mouse model for progeria by generating transgenics carrying a human bacterial artificial chromosome that harbors the common HGPS mutation. These mice develop progressive loss of vascular smooth muscle cells in the medial layer of large arteries, in a pattern very similar to that seen in children with HGPS. This mouse model should prove valuable for testing experimental therapies for this devastating disorder and for exploring cardiovascular disease in general. JF - Proceedings of the National Academy of Sciences, USA AU - Varga, Renee AU - Eriksson, Maria AU - Erdos, Michael R AU - Olive, Michelle AU - Harten, Ingrid AU - Kolodgie, Frank AU - Capell, Brian C AU - Cheng, Jun AU - Faddah, Dina AU - Perkins, Stacie AU - Avallone, Hedwig AU - San, Hong AU - Qu, Xuan AU - Ganesh, Santhi AU - Gordon, Leslie B AU - Virmani, Renu AU - Wight, Thomas N AU - Nabel, Elizabeth G AU - Collins, Francis S AD - Genome Technology Branch and Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 3250 EP - 3255 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 9 SN - 0027-8424, 0027-8424 KW - Hutchinson-Gilford progeria syndrome KW - mice KW - progerin KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Smooth muscle KW - Progeria KW - Missense mutation KW - Arteries KW - Aging KW - Stroke KW - Point mutation KW - Animal models KW - Lamins KW - Children KW - Myocardial infarction KW - Bacterial artificial chromosomes KW - Gene deletion KW - Cardiovascular diseases KW - LMNA protein KW - Heart diseases KW - Vascular system KW - J 02410:Animal Diseases KW - G 07397:Rodentia (mice) KW - G 07444:Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17086767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Progressive+vascular+smooth+muscle+cell+defects+in+a+mouse+model+of+Hutchinson-Gilford+progeria+syndrome&rft.au=Varga%2C+Renee%3BEriksson%2C+Maria%3BErdos%2C+Michael+R%3BOlive%2C+Michelle%3BHarten%2C+Ingrid%3BKolodgie%2C+Frank%3BCapell%2C+Brian+C%3BCheng%2C+Jun%3BFaddah%2C+Dina%3BPerkins%2C+Stacie%3BAvallone%2C+Hedwig%3BSan%2C+Hong%3BQu%2C+Xuan%3BGanesh%2C+Santhi%3BGordon%2C+Leslie+B%3BVirmani%2C+Renu%3BWight%2C+Thomas+N%3BNabel%2C+Elizabeth+G%3BCollins%2C+Francis+S&rft.aulast=Varga&rft.aufirst=Renee&rft.date=2006-02-01&rft.volume=103&rft.issue=9&rft.spage=3250&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Progeria; Smooth muscle; Missense mutation; Arteries; Point mutation; Stroke; Aging; Animal models; Lamins; Children; Myocardial infarction; Bacterial artificial chromosomes; Gene deletion; Cardiovascular diseases; LMNA protein; Vascular system; Heart diseases ER - TY - JOUR T1 - Immuno-spin trapping of DNA radicals AN - 17075407; 6703419 AB - The detection of DNA radicals by immuno-spin trapping (IST) is based on the trapping of radicals with 5,5-dimethyl-1-pyrroline N-oxide (DMPO), forming stable nitrone adducts that are then detected using an anti-DMPO serum. DNA radicals are very reactive species, and because they are paramagnetic they have previously been detected only by electron spin resonance (ESR) with or without spin trapping, which is not available in most bioresearch laboratories. IST combines the simplicity, reliability, specificity and sensitivity of spin trapping with heterogeneous immunoassays for the detection of DNA radicals, and complements existing methods for the measurement of oxidatively generated DNA damage. Here we have used IST to demonstrate that DMPO traps Cu(II)- H sub(2)O sub(2)-induced DNA radicals in situ and in real time, forming DMPO-DNA nitrone adducts, but preventing both 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo- dG) formation and DNA fragmentation. We also applied IST to detect DNA radicals in rat hepatocytes exposed to Cu(II) and H sub(2)O sub(2) under nonlethal conditions. JF - Nature Methods AU - Ramirez, Dario C AU - Mejiba, Sandra E Gomez AU - Mason, Ronald P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Dr., Research Triangle Park, North Carolina 27709, USA., ramirez1@niehs.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 123 EP - 127 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 2 SN - 1548-7091, 1548-7091 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Hepatocytes KW - Adducts KW - N-Oxides KW - Trapping KW - DNA fragmentation KW - DNA damage KW - Hydrogen peroxide KW - Traps KW - Immunoassays KW - Radicals KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17075407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=Immuno-spin+trapping+of+DNA+radicals&rft.au=Ramirez%2C+Dario+C%3BMejiba%2C+Sandra+E+Gomez%3BMason%2C+Ronald+P&rft.aulast=Ramirez&rft.aufirst=Dario&rft.date=2006-02-01&rft.volume=3&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth852 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Radicals; Trapping; Adducts; DNA damage; Traps; Hydrogen peroxide; N-Oxides; Hepatocytes; Immunoassays; DNA fragmentation DO - http://dx.doi.org/10.1038/nmeth852 ER - TY - JOUR T1 - Potential role of pulsed-high intensity focused ultrasound in gene therapy AN - 1496883251; 18787992 AB - As the understanding of human cancer biology increases, new potential strategies for gene therapy are being proposed and evaluated. However, safe and efficient gene transfer continues to be the major hurdle for its implementation in the clinic. Preclinical studies have shown how pulsed-high intensity focused ultrasound (HIFU) exposures can be combined with different modes of administration (local, intravascular and systemic) to improve local delivery of genes and other therapeutic agents. Using image guidance, exposures are given, where short pulses of energy create predominantly mechanical/structural effects in the tissues as opposed to thermal ones. The result is an increase in both extravasation and interstitial diffusion of macromolecules, which occur nondestructively and reversibly. Ultrasound contrast agents can also be added, which enhance acoustic cavitation activity and consequently sonoporation. By being able to locally increase the uptake and expression of DNA, pulsed-HIFU holds much promise to further the use and applications of gene therapy for treating cancer and other pathological conditions. JF - Future Oncology AU - Frenkel, Victor AU - Li, King CP AD - super(1)Diagnostic Radiology Department, Clinial Center, National Institutes of Health, Bethesda, MD, USA., vfrenkel@cc.nih.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 111 EP - 119 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 2 IS - 1 SN - 1479-6694, 1479-6694 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Acoustics KW - Ultrasound KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496883251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+Oncology&rft.atitle=Potential+role+of+pulsed-high+intensity+focused+ultrasound+in+gene+therapy&rft.au=Frenkel%2C+Victor%3BLi%2C+King+CP&rft.aulast=Frenkel&rft.aufirst=Victor&rft.date=2006-02-01&rft.volume=2&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Future+Oncology&rft.issn=14796694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Number of references - 1 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Ultrasound ER - TY - CPAPER T1 - Immune Stimulators T2 - 4th Cytokines and Inflammation Conference AN - 39862403; 4089763 DE: JF - 4th Cytokines and Inflammation Conference AU - Wang, Ji Ming Y1 - 2006/01/30/ PY - 2006 DA - 2006 Jan 30 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Cytokines+and+Inflammation+Conference&rft.atitle=Immune+Stimulators&rft.au=Wang%2C+Ji+Ming&rft.aulast=Wang&rft.aufirst=Ji&rft.date=2006-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/ebrochure/cytokines%20&%20infl.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemokine Receptors in Organ-Selective Melanoma Metastasis T2 - 4th Cytokines and Inflammation Conference AN - 39844462; 4089761 JF - 4th Cytokines and Inflammation Conference AU - Hwang, Sam Y1 - 2006/01/30/ PY - 2006 DA - 2006 Jan 30 KW - Melanoma KW - Chemokine receptors KW - Metastases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39844462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Cytokines+and+Inflammation+Conference&rft.atitle=Chemokine+Receptors+in+Organ-Selective+Melanoma+Metastasis&rft.au=Hwang%2C+Sam&rft.aulast=Hwang&rft.aufirst=Sam&rft.date=2006-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/ebrochure/cytokines%20&%20infl.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-7 Signals Survival and Proliferation of T Cells T2 - 4th Cytokines and Inflammation Conference AN - 39782546; 4089746 JF - 4th Cytokines and Inflammation Conference AU - Durum, Scott Y1 - 2006/01/30/ PY - 2006 DA - 2006 Jan 30 KW - Cell proliferation KW - Lymphocytes T KW - Interleukin 7 KW - Cell survival KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39782546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Cytokines+and+Inflammation+Conference&rft.atitle=IL-7+Signals+Survival+and+Proliferation+of+T+Cells&rft.au=Durum%2C+Scott&rft.aulast=Durum&rft.aufirst=Scott&rft.date=2006-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/ebrochure/cytokines%20&%20infl.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-6 and Cancer T2 - 4th Cytokines and Inflammation Conference AN - 39775592; 4089767 JF - 4th Cytokines and Inflammation Conference AU - Farrar, William Y1 - 2006/01/30/ PY - 2006 DA - 2006 Jan 30 KW - Cancer KW - Interleukin 6 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39775592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Cytokines+and+Inflammation+Conference&rft.atitle=IL-6+and+Cancer&rft.au=Farrar%2C+William&rft.aulast=Farrar&rft.aufirst=William&rft.date=2006-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/ebrochure/cytokines%20&%20infl.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weak Alignment Offers Shortcuts in NMR Structure Determination T2 - 2006 Keystone Symposia on Structural Genomics (J5) AN - 39820396; 4078108 JF - 2006 Keystone Symposia on Structural Genomics (J5) AU - Bax, Ad Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 KW - N.M.R. KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Structural+Genomics+%28J5%29&rft.atitle=Weak+Alignment+Offers+Shortcuts+in+NMR+Structure+Determination&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2006-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Structural+Genomics+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Structure Imitative: Progress and Plans T2 - 2006 Keystone Symposia on Structural Genomics (J5) AN - 39816941; 4078115 JF - 2006 Keystone Symposia on Structural Genomics (J5) AU - Norvell, John C Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 KW - Protein structure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Structural+Genomics+%28J5%29&rft.atitle=Protein+Structure+Imitative%3A+Progress+and+Plans&rft.au=Norvell%2C+John+C&rft.aulast=Norvell&rft.aufirst=John&rft.date=2006-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Structural+Genomics+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time-Resolved X-Ray Crystallography: Watching Proteins Function in Real Time T2 - 2006 Keystone Symposia on Frontiers in Structural Biology (J6) AN - 39791914; 4078148 JF - 2006 Keystone Symposia on Frontiers in Structural Biology (J6) AU - Anfinrud, Philip Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 KW - X-ray crystallography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39791914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Frontiers+in+Structural+Biology+%28J6%29&rft.atitle=Time-Resolved+X-Ray+Crystallography%3A+Watching+Proteins+Function+in+Real+Time&rft.au=Anfinrud%2C+Philip&rft.aulast=Anfinrud&rft.aufirst=Philip&rft.date=2006-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Frontiers+in+Structural+Biology+%28J6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=816 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. AN - 70690931; 16303758 AB - Proline oxidase (POX) is a redox enzyme localized in the mitochondrial inner membrane. We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS). The peroxisome proliferator-activated receptor gamma (PPARgamma) ligand troglitazone was found to activate the POX promoter in colon cancer cells. PPARgamma ligands have been reported to induce apoptosis in a variety of cancer cells. In HCT116 cells expressing a wild-type PPARgamma, troglitazone enhanced the binding of PPARgamma to PPAR-responsive element in the POX promoter and increased endogenous POX expression. Blocking of PPARgamma activation either by antagonist GW9662 or deletion of PPAR-responsive element in the POX promoter only partially decreased the POX promoter activation in response to troglitazone, indicating also the involvement of PPARgamma-independent mechanisms. Further, troglitazone also induced p53 protein expression in HCT116 cells, which may be the possible mechanism for PPARgamma-independent POX activation, since POX has been shown to be a downstream mediator in p53-induced apoptosis. In HCT15 cells, with both mutant p53 and mutant PPARgamma, there was no effect of troglitazone on POX activation, whereas in HT29 cells, with a mutant p53 and wild type PPARgamma, increased activation was observed by ligand stimulation, indicating that both PPARgamma-dependent and -independent mechanisms are involved in the troglitazone-induced POX expression. A time- and dose-dependent increase in POX catalytic activity was obtained in HCT116 cells treated with troglitazone with a concomitant increase in the production of intracellular ROS. Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms. JF - The Journal of biological chemistry AU - Pandhare, Jui AU - Cooper, Sandra K AU - Phang, James M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, MD 21702, USA. Y1 - 2006/01/27/ PY - 2006 DA - 2006 Jan 27 SP - 2044 EP - 2052 VL - 281 IS - 4 SN - 0021-9258, 0021-9258 KW - 2-chloro-5-nitrobenzanilide KW - 0 KW - Anilides KW - Chromans KW - Ligands KW - PPAR gamma KW - RNA, Messenger KW - Reactive Oxygen Species KW - Thiazolidinediones KW - Tumor Suppressor Protein p53 KW - Proline Oxidase KW - EC 1.5.3.- KW - troglitazone KW - I66ZZ0ZN0E KW - Index Medicus KW - Plasmids -- metabolism KW - Apoptosis KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Humans KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - Tumor Suppressor Protein p53 -- metabolism KW - Protein Binding KW - Anilides -- pharmacology KW - Cloning, Molecular KW - Promoter Regions, Genetic KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Chromatin Immunoprecipitation KW - Up-Regulation KW - Time Factors KW - Mutation KW - Cell Line KW - Catalysis KW - Gene Expression Regulation, Enzymologic KW - Chromans -- pharmacology KW - Thiazolidinediones -- pharmacology KW - Proline Oxidase -- metabolism KW - Proline Oxidase -- physiology KW - PPAR gamma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70690931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Proline+oxidase%2C+a+proapoptotic+gene%2C+is+induced+by+troglitazone%3A+evidence+for+both+peroxisome+proliferator-activated+receptor+gamma-dependent+and+-independent+mechanisms.&rft.au=Pandhare%2C+Jui%3BCooper%2C+Sandra+K%3BPhang%2C+James+M&rft.aulast=Pandhare&rft.aufirst=Jui&rft.date=2006-01-27&rft.volume=281&rft.issue=4&rft.spage=2044&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III AN - 17216030; 6906918 AB - Members of the ribonuclease III (RNase III) family are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in their active centers and a two-base 3' overhang in their products. While Dicer, which produces small interfering RNAs, is currently the focus of intense interest, the structurally simpler bacterial RNase III serves as a paradigm for the entire family. Here, we present the crystal structure of an RNase III-product complex, the first catalytic complex observed for the family. A 7 residue linker within the protein facilitates induced fit in protein-RNA recognition. A pattern of protein-RNA interactions, defined by four RNA binding motifs in RNase III and three protein-interacting boxes in dsRNA, is responsible for substrate specificity, while conserved amino acid residues and divalent cations are responsible for scissile-bond cleavage. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members. JF - Cell AU - Gan, Jianhua AU - Tropea, Joseph E AU - Austin, Brian P AU - Court, Donald L AU - Waugh, David S AU - Ji, Xinhua AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA, jix@ncifcrf.gov Y1 - 2006/01/27/ PY - 2006 DA - 2006 Jan 27 SP - 355 EP - 366 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 124 IS - 2 SN - 0092-8674, 0092-8674 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Amino acids KW - siRNA KW - Cations KW - Double-stranded RNA KW - Crystal structure KW - Ribonuclease III KW - Substrate specificity KW - Ribonuclease KW - Hydrolysis KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17216030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Structural+Insight+into+the+Mechanism+of+Double-Stranded+RNA+Processing+by+Ribonuclease+III&rft.au=Gan%2C+Jianhua%3BTropea%2C+Joseph+E%3BAustin%2C+Brian+P%3BCourt%2C+Donald+L%3BWaugh%2C+David+S%3BJi%2C+Xinhua&rft.aulast=Gan&rft.aufirst=Jianhua&rft.date=2006-01-27&rft.volume=124&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2005.11.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amino acids; Cations; siRNA; Double-stranded RNA; Crystal structure; Ribonuclease; Substrate specificity; Ribonuclease III; Hydrolysis DO - http://dx.doi.org/10.1016/j.cell.2005.11.034 ER - TY - JOUR T1 - RNA interference targeting Akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells AN - 17111072; 6741693 AB - Overactivation of the PI3 kinase/Akt pathway plays an essential role in the development and progression of various tumors. Akt is a key component of this pathway and hyperactivated in different tumors including neuroblastoma and glioma. In the present study, we tested the therapeutic efficacy of siRNA targeting Akt in inducing apoptotic cell death in NBFL cells (a human neuroblastoma cell line) subjected to anoxia/reoxygenation (A/R), a process that has been shown to modulate growth and progression of malignant tumors. We observed that siRNA targeting Akt effectively induced apoptotic cell death in NBFL cells (as determined by TUNEL assay and activated caspase-3 immunoreactivity) under normoxic conditions, an effect that was greatly enhanced under conditions of A/R. These findings underscore the importance of Akt signaling in promoting survival of neuroblastoma cells and may have potential therapeutic applications. JF - Brain Research AU - Liu, X H AU - Yu, E Z AU - Li, Y Y AU - Rollwagen, F M AU - Kagan, E AD - Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA, liuxiuhuai@mail.nih.gov Y1 - 2006/01/27/ PY - 2006 DA - 2006 Jan 27 SP - 24 EP - 30 VL - 1070 IS - 1 SN - 0006-8993, 0006-8993 KW - CSA Neurosciences Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Apoptosis KW - Therapeutic applications KW - Tumors KW - Neuroblastoma KW - Anoxia KW - Brain tumors KW - 1-Phosphatidylinositol 3-kinase KW - siRNA KW - Immunoreactivity KW - Neuroblastoma cells KW - AKT protein KW - Caspase-3 KW - RNA-mediated interference KW - Glioma KW - Signal transduction KW - N 14830:RNA KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17111072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=RNA+interference+targeting+Akt+promotes+apoptosis+in+hypoxia-exposed+human+neuroblastoma+cells&rft.au=Liu%2C+X+H%3BYu%2C+E+Z%3BLi%2C+Y+Y%3BRollwagen%2C+F+M%3BKagan%2C+E&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-01-27&rft.volume=1070&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2005.11.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Therapeutic applications; Tumors; Neuroblastoma; Anoxia; Brain tumors; 1-Phosphatidylinositol 3-kinase; siRNA; Immunoreactivity; Caspase-3; AKT protein; Neuroblastoma cells; RNA-mediated interference; Glioma; Signal transduction DO - http://dx.doi.org/10.1016/j.brainres.2005.11.041 ER - TY - JOUR T1 - Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. AN - 70715267; 16247478 AB - The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in p53 lead to hypermutability to ionizing radiation. To investigate further how p53 is involved in regulating mutational processes, we used 8K cDNA microarrays to compare the patterns of gene expression among three closely related human cell lines with different p53 status including TK6 (wild-type p53), NH32 (p53-null), and WTK1 (mutant p53). Total RNA samples were collected at 1, 3, 6, 9, and 24 h after 10 Gy gamma-irradiation. Template-based clustering analysis of the gene expression over the time course showed that 464 genes are either up or downregulated by at least twofold following radiation treatment. In addition, cluster analyses of gene expression profiles among these three cell lines revealed distinct patterns. In TK6, 165 genes were upregulated, while 36 genes were downregulated. In contrast, in WTK1 75 genes were upregulated and 12 genes were downregulated. In NH32, only 54 genes were upregulated. Furthermore, we found several genes associated with DNA repair namely p53R2, DDB2, XPC, PCNA, BTG2, and MSH2 that were highly induced in TK6 compared to WTK1 and NH32. p53R2, which is regulated by the tumor suppressor p53, is a small subunit of ribonucleotide reductase. To determine whether it is involved in radiation-induced mutagenesis, p53R2 protein was inhibited by siRNA in TK6 cells and followed by 2 Gy radiation. The background mutation frequencies at the TK locus of siRNA-transfected TK6 cells were about three times higher than those seen in TK6 cells. The mutation frequencies of siRNA-transfected TK6 cells after 2 Gy radiation were significantly higher than the irradiated TK6 cells without p53R2 knock down. These results indicate that p53R2 was induced by p53 protein and is involved in protecting against radiation-induced mutagenesis. JF - Oncogene AU - Tsai, M-H AU - Chen, X AU - Chandramouli, G V R AU - Chen, Y AU - Yan, H AU - Zhao, S AU - Keng, P AU - Liber, H L AU - Coleman, C N AU - Mitchell, J B AU - Chuang, E Y AD - Radiation Biology and Oncology Branches, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01/26/ PY - 2006 DA - 2006 Jan 26 SP - 622 EP - 632 VL - 25 IS - 4 SN - 0950-9232, 0950-9232 KW - NF-kappa B KW - 0 KW - TGFB1 protein, human KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Gene Expression Profiling KW - Transforming Growth Factor beta -- physiology KW - DNA Damage KW - Cells, Cultured KW - Humans KW - Gene Expression -- radiation effects KW - NF-kappa B -- metabolism KW - Tumor Suppressor Protein p53 -- physiology KW - DNA Repair KW - Transcription, Genetic -- radiation effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70715267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Transcriptional+responses+to+ionizing+radiation+reveal+that+p53R2+protects+against+radiation-induced+mutagenesis+in+human+lymphoblastoid+cells.&rft.au=Tsai%2C+M-H%3BChen%2C+X%3BChandramouli%2C+G+V+R%3BChen%2C+Y%3BYan%2C+H%3BZhao%2C+S%3BKeng%2C+P%3BLiber%2C+H+L%3BColeman%2C+C+N%3BMitchell%2C+J+B%3BChuang%2C+E+Y&rft.aulast=Tsai&rft.aufirst=M-H&rft.date=2006-01-26&rft.volume=25&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smad4-expression is decreased in breast cancer tissues: a retrospective study. AN - 67787378; 16438724 AB - Although transforming growth factor beta (TGF-beta) typically inhibits proliferation of epithelial cells, consistent with a tumor suppressor activity, it paradoxically also exhibits pro-metastatic activity in the later stages of carcinogenesis. Since tumors often display altered TGF-beta signaling, particularly involving the Smad-pathway, we investigated the role of Smad4-expression in breast cancer. Smad4 expression was investigated by immunohistochemistry in formalin-fixed, paraffin-embedded tissue from 197 samples of primary breast cancer obtained between 1986 and 1998. The prognostic value of Smad4-expression was analyzed. Smad4 expression was found to be reduced in lobular and ductal breast carcinoma as compared to surrounding uninvolved lobular and ductal breast epithelia (p < 0.001, n = 50). Smad4-expression correlated positively with expression of TGF-beta-receptor I (p < 0.001, n = 197) and TGF-beta-receptor II (p < 0.001, n = 197), but showed no significant correlation with tumor size, metastases, nodal status, histological grade, histological type, or estrogen receptor expression. While not achieving statistical significance, there was a trend towards longer survival times in patients with Smad4 negative tumors. According to the suggested role of Smad4 as a tumor suppressor we observed that expression of Smad4 is lower in human breast cancer than in surrounding breast epithelium. However, we also observed a trend towards longer survival times in Smad4-negative patients, indicating the complex role of TGF-beta signaling in tumor progression. JF - BMC cancer AU - Stuelten, Christina H AU - Buck, Miriam B AU - Dippon, Juergen AU - Roberts, Anita B AU - Fritz, Peter AU - Knabbe, Cornelius AD - Department of Clinical Chemistry, Robert Bosch Hospital, Stuttgart, Germany. chrisstu@mail.nih.gov Y1 - 2006/01/26/ PY - 2006 DA - 2006 Jan 26 SP - 25 VL - 6 KW - Receptors, Estrogen KW - 0 KW - Receptors, Transforming Growth Factor beta KW - SMAD4 protein, human KW - Smad4 Protein KW - Index Medicus KW - Receptors, Transforming Growth Factor beta -- analysis KW - Humans KW - Retrospective Studies KW - Prognosis KW - Aged KW - Cell Line, Tumor KW - Receptors, Estrogen -- analysis KW - Survival Rate KW - Aged, 80 and over KW - Adult KW - Breast -- chemistry KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- pathology KW - Smad4 Protein -- analysis KW - Breast Neoplasms -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67787378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Smad4-expression+is+decreased+in+breast+cancer+tissues%3A+a+retrospective+study.&rft.au=Stuelten%2C+Christina+H%3BBuck%2C+Miriam+B%3BDippon%2C+Juergen%3BRoberts%2C+Anita+B%3BFritz%2C+Peter%3BKnabbe%2C+Cornelius&rft.aulast=Stuelten&rft.aufirst=Christina&rft.date=2006-01-26&rft.volume=6&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-06 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 1999;10 Suppl 4:56-9 [10436786] EMBO J. 1998 Jul 15;17(14):4056-65 [9670020] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1427-32 [9990040] Am J Pathol. 2000 Jan;156(1):37-43 [10623651] Cancer Res. 2000 Apr 1;60(7):2002-6 [10766191] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5 [10781087] Biochem Biophys Res Commun. 2000 Jun 16;272(3):705-11 [10860819] Int J Cancer. 2001 Jan 1;91(1):76-82 [11149423] Breast Cancer Res. 2000;2(5):331-4 [11250725] Breast Cancer Res Treat. 2001 Jan;65(2):101-10 [11261825] Anal Quant Cytol Histol. 2001 Apr;23(2):109-17 [11332076] Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):917-23 [11535541] J Biol Chem. 2001 Nov 16;276(46):42908-14 [11555647] J Endocrinol. 2002 Jan;172(1):187-98 [11786386] Curr Opin Genet Dev. 2002 Feb;12(1):22-9 [11790550] Cancer Res. 2002 Jan 15;62(2):497-505 [11809701] Trends Genet. 2002 Feb;18(2):96-103 [11818142] Clin Cancer Res. 2002 Jun;8(6):1838-42 [12060625] Gut. 2002 Jul;51(1):56-9 [12077092] Cancer Res. 2003 Jan 15;63(2):277-81 [12543773] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8430-5 [12808151] J Biol Chem. 2003 Jul 25;278(30):27853-63 [12740389] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8621-3 [12861075] J Biol Chem. 2003 Aug 15;278(33):31043-8 [12813045] J Biol Chem. 2003 Aug 29;278(35):33571-82 [12794086] J Clin Invest. 2003 Oct;112(7):1116-24 [14523048] Cancer Res. 2003 Dec 1;63(23):8284-92 [14678987] Clin Cancer Res. 2004 Jan 15;10(2):491-8 [14760070] Mod Pathol. 2004 Jul;17(7):756-64 [15073601] Cancer Res. 2004 Jul 1;64(13):4523-30 [15231662] Cell. 1987 Feb 13;48(3):417-28 [2879636] Pathologe. 1987 May;8(3):138-40 [3303008] J Cell Physiol. 1989 Nov;141(2):353-61 [2808542] Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] Am J Clin Oncol. 1991;14 Suppl 2:S15-20 [1835818] Cancer Res. 1992 Dec 15;52(24):6949-52 [1458485] Int J Cancer. 1994 Mar 1;56(5):736-42 [8314352] Trends Biochem Sci. 1994 Dec;19(12):548-53 [7846768] Science. 1996 Jan 19;271(5247):350-3 [8553070] Cancer Res. 1996 Jun 1;56(11):2527-30 [8653691] Oncogene. 1997 Apr 24;14(16):1891-9 [9150356] Nature. 1997 Dec 4;390(6659):465-71 [9393997] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13909-14 [16172383] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - RNAi-Mediated Epigenetic Control of the Fission Yeast Genome T2 - 2006 Keystone Symposia on RNAi and Related Pathways (B2) AN - 39819981; 4078010 JF - 2006 Keystone Symposia on RNAi and Related Pathways (B2) AU - Grewal, Shiv I.S. Y1 - 2006/01/26/ PY - 2006 DA - 2006 Jan 26 KW - Genomes KW - Epigenetics KW - Schizosaccharomyces pombe KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39819981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+RNAi+and+Related+Pathways+%28B2%29&rft.atitle=RNAi-Mediated+Epigenetic+Control+of+the+Fission+Yeast+Genome&rft.au=Grewal%2C+Shiv+I.S.&rft.aulast=Grewal&rft.aufirst=Shiv&rft.date=2006-01-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+RNAi+and+Related+Pathways+%28B2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=813 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Clinical Trials with Novel Agents: The NCI Experience T2 - 2006 Special Conference on Drugging the Cancer Genome: Developing Rational Combination Therapies for Multigene Cancers AN - 39874627; 4089864 JF - 2006 Special Conference on Drugging the Cancer Genome: Developing Rational Combination Therapies for Multigene Cancers AU - Christian, Michaele C Y1 - 2006/01/25/ PY - 2006 DA - 2006 Jan 25 KW - Clinical trials KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+Drugging+the+Cancer+Genome%3A+Developing+Rational+Combination+Therapies+for+Multigene+Cancers&rft.atitle=Combination+Clinical+Trials+with+Novel+Agents%3A+The+NCI+Experience&rft.au=Christian%2C+Michaele+C&rft.aulast=Christian&rft.aufirst=Michaele&rft.date=2006-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+Drugging+the+Cancer+Genome%3A+Developing+Rational+Combination+Therapies+for+Multigene+Cancers&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page5302.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor. AN - 70685316; 16411743 AB - The ligand-induced activation of G protein-coupled receptors (GPCRs) is predicted to involve pronounced conformational changes on the intracellular surface or the receptor proteins. A reorientation of the cytoplasmic end of transmembrane domain VI (TM VI) is thought to play a key role in GPCR activation and productive receptor/G protein coupling. Disulfide cross-linking studies with solubilized, Cys-substituted mutant versions of bovine rhodopsin and the M3 muscarinic acetylcholine receptor suggested that the cytoplasmic end of TM VI is conformationally highly flexible, even in the absence of activating ligands (Farrens, D. L., et al. (1996) Science 274, 768-770; Zeng, F. Y., et al. (1999) J. Biol. Chem. 274, 16629-16640). To test the hypothesis that the promiscuous disulfide cross-linking pattern observed in these studies was caused by the use of solubilized receptor proteins endowed with increased conformational flexibility, we employed a recently developed in situ disulfide cross-linking strategy that allows the detection of disulfide bonds in Cys-substituted mutant M3 muscarinic receptors present in their native membrane environment. Specifically, we used membranes prepared from transfected COS-7 cells to analyze a series of double Cys mutant M3 receptors containing one Cys residue within the sequence K484(6.29) to S493(6.38) at the cytoplasmic end of TM VI and a second Cys residue at the cytoplasmic end of TM III (I169C(3.54)). This analysis revealed a disulfide cross-linking pattern that was strikingly more restricted than that observed previously with solubilized receptor proteins, both in the absence and in the presence of the muscarinic agonist, carbachol. Carbachol stimulated the formation of disulfide bonds in only two of the 10 analyzed mutant muscarinic receptors, I169C(3.54)/K484C(6.29) and I169C(3.54)/A488C(6.33), consistent with an agonist-induced rotation of the cytoplasmic end of TM VI. These findings underline the usefulness of analyzing the structural and dynamic properties of GPCRs in their native lipid environment. JF - Biochemistry AU - Ward, Stuart D C AU - Hamdan, Fadi F AU - Bloodworth, Lanh M AU - Siddiqui, Nasir A AU - Li, Jian Hua AU - Wess, Jürgen AD - Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive, Bethesda, Maryland 20892, USA. Y1 - 2006/01/24/ PY - 2006 DA - 2006 Jan 24 SP - 676 EP - 685 VL - 45 IS - 3 SN - 0006-2960, 0006-2960 KW - Cross-Linking Reagents KW - 0 KW - Disulfides KW - Molecular Probes KW - Receptor, Muscarinic M3 KW - Deuterium KW - AR09D82C7G KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - COS Cells KW - Models, Molecular KW - Cercopithecus aethiops KW - Protein Structure, Tertiary KW - Binding Sites KW - Disulfides -- chemistry KW - Cross-Linking Reagents -- chemistry KW - Cytoplasm -- metabolism KW - Receptor, Muscarinic M3 -- metabolism KW - Cell Membrane -- metabolism KW - Disulfides -- metabolism KW - Receptor, Muscarinic M3 -- chemistry KW - Receptor, Muscarinic M3 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70685316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Use+of+an+in+situ+disulfide+cross-linking+strategy+to+study+the+dynamic+properties+of+the+cytoplasmic+end+of+transmembrane+domain+VI+of+the+M3+muscarinic+acetylcholine+receptor.&rft.au=Ward%2C+Stuart+D+C%3BHamdan%2C+Fadi+F%3BBloodworth%2C+Lanh+M%3BSiddiqui%2C+Nasir+A%3BLi%2C+Jian+Hua%3BWess%2C+J%C3%BCrgen&rft.aulast=Ward&rft.aufirst=Stuart+D&rft.date=2006-01-24&rft.volume=45&rft.issue=3&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-17 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Live Cell Imaging of the Endocytosis and the Intracellular Trafficking of Multifunctional Lipid Nanoparticles T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39945022; 4100586 JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Zhang, T AU - Danthi, N AU - Xie, J AU - Lu, P. AU - Li, K C Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Lipids KW - Endocytosis KW - Imaging techniques KW - Nanoparticles KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39945022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=Live+Cell+Imaging+of+the+Endocytosis+and+the+Intracellular+Trafficking+of+Multifunctional+Lipid+Nanoparticles&rft.au=Zhang%2C+T%3BDanthi%2C+N%3BXie%2C+J%3BLu%2C+P.%3BLi%2C+K+C&rft.aulast=Zhang&rft.aufirst=T&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Scanning System for Fluorescence Lifetime Imaging T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39870679; 4101182 JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Hassan, M AU - Gannot, I AU - Chernomordik, V V AU - Smith, P D AU - Pursley, R AU - Gandjbakhche, A H Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Fluorescence KW - Scanning KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=A+Scanning+System+for+Fluorescence+Lifetime+Imaging&rft.au=Hassan%2C+M%3BGannot%2C+I%3BChernomordik%2C+V+V%3BSmith%2C+P+D%3BPursley%2C+R%3BGandjbakhche%2C+A+H&rft.aulast=Hassan&rft.aufirst=M&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Critical Role for O-Cell M3 Muscarinic Acetylcholine Receptors in Regulating Insulin Release and Blood Glucose Homeostasis In Vivo T2 - 2006 Keystone Symposia on Diabetes Mellitus and the Control of Cellular Energy Metabolism (J3) AN - 39820880; 4078245 JF - 2006 Keystone Symposia on Diabetes Mellitus and the Control of Cellular Energy Metabolism (J3) AU - Gautam, Dinesh C Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Blood KW - Glucose KW - Acetylcholine receptors (muscarinic) KW - Insulin KW - Homeostasis KW - Neurotransmitters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Diabetes+Mellitus+and+the+Control+of+Cellular+Energy+Metabolism+%28J3%29&rft.atitle=A+Critical+Role+for+O-Cell+M3+Muscarinic+Acetylcholine+Receptors+in+Regulating+Insulin+Release+and+Blood+Glucose+Homeostasis+In+Vivo&rft.au=Gautam%2C+Dinesh+C&rft.aulast=Gautam&rft.aufirst=Dinesh&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Diabetes+Mellitus+and+the+Control+of+Cellular+Energy+Metabolism+%28J3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=781 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visual Enhancement of Laparoscopic Nephrectomy: Application of an Algorithm on the 3-CCD Camera T2 - 2006 Symposium on Biomedical Optics (BIOS 2006) AN - 39792132; 4100820 JF - 2006 Symposium on Biomedical Optics (BIOS 2006) AU - Crane, N J Y1 - 2006/01/21/ PY - 2006 DA - 2006 Jan 21 KW - Algorithms KW - Cameras KW - Nephrectomy KW - Laparoscopy KW - Mathematical models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39792132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.atitle=Visual+Enhancement+of+Laparoscopic+Nephrectomy%3A+Application+of+an+Algorithm+on+the+3-CCD+Camera&rft.au=Crane%2C+N+J&rft.aulast=Crane&rft.aufirst=N&rft.date=2006-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Symposium+on+Biomedical+Optics+%28BIOS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Conferences/Programs/06/pw/bios/PW06_BiOS_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. AN - 70694063; 16421428 AB - This pediatric phase I trial of tipifarnib determined the maximum-tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of tipifarnib in children with refractory solid tumors and neurofibromatosis type 1 (NF1) -related plexiform neurofibromas. Tipifarnib was administered twice daily for 21 days, repeated every 28 days starting at 150 mg/m2/dose (n = 4), with escalations to 200 (n = 12), 275 (n = 12), and 375 (n = 6) mg/m2/dose. The MTD was also evaluated on a chronic continuous dosing schedule (n = 6). Pharmacokinetic sampling was performed for 36 hours after the first dose and peripheral-blood mononuclear cells (PBMCs) were collected at baseline and steady state for determination of farnesyl protein transferase (FTase) activity and HDJ-2 farnesylation. Twenty-three solid tumor and 17 NF1 patients were assessable for toxicity. The MTD was 200 mg/m2/dose, and dose-limiting toxicities on cycle 1 were myelosuppression, rash, nausea, vomiting, and diarrhea. The 200 mg/m2/dose was also tolerable on the continuous dosing schedule. Cumulative toxicity was not observed in the 17 NF1 patients who received a median of 10 cycles (range, 1 to 32 cycles). The plasma pharmacokinetics of tipifarnib were highly variable but not age dependent. At steady state on 200 mg/m2/dose, FTase activity was 30% compared with baseline, and farnesylation of HDJ-2 was inhibited in PBMCs. Oral tipifarnib is well tolerated in children receiving the drug twice daily for 21 days and a continuous dosing schedule at 200 mg/m2/dose, which is equivalent to the MTD in adults. The pharmacokinetic profile of tipifarnib in children is similar to that in adults, and at the MTD, FTase is inhibited in PBMC in vivo. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Widemann, Brigitte C AU - Salzer, Wanda L AU - Arceci, Robert J AU - Blaney, Susan M AU - Fox, Elizabeth AU - End, David AU - Gillespie, Andrea AU - Whitcomb, Patricia AU - Palumbo, Joseph S AU - Pitney, Aaron AU - Jayaprakash, Nalini AU - Zannikos, Peter AU - Balis, Frank M AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. widemanb@mail.nih.gov Y1 - 2006/01/20/ PY - 2006 DA - 2006 Jan 20 SP - 507 EP - 516 VL - 24 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Enzyme Inhibitors KW - Quinolones KW - Farnesyltranstransferase KW - EC 2.5.1.29 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Drug Administration Schedule KW - Drug Eruptions -- etiology KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Child KW - Antineoplastic Agents -- adverse effects KW - Child, Preschool KW - Gastrointestinal Tract -- drug effects KW - Treatment Outcome KW - Adolescent KW - Antineoplastic Agents -- pharmacology KW - Bone Marrow -- drug effects KW - Male KW - Female KW - Quinolones -- adverse effects KW - Neurofibromatosis 1 -- drug therapy KW - Enzyme Inhibitors -- adverse effects KW - Enzyme Inhibitors -- administration & dosage KW - Quinolones -- pharmacokinetics KW - Neurofibroma, Plexiform -- drug therapy KW - Farnesyltranstransferase -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacokinetics KW - Quinolones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70694063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+trial+and+pharmacokinetic+study+of+the+farnesyltransferase+inhibitor+tipifarnib+in+children+with+refractory+solid+tumors+or+neurofibromatosis+type+I+and+plexiform+neurofibromas.&rft.au=Widemann%2C+Brigitte+C%3BSalzer%2C+Wanda+L%3BArceci%2C+Robert+J%3BBlaney%2C+Susan+M%3BFox%2C+Elizabeth%3BEnd%2C+David%3BGillespie%2C+Andrea%3BWhitcomb%2C+Patricia%3BPalumbo%2C+Joseph+S%3BPitney%2C+Aaron%3BJayaprakash%2C+Nalini%3BZannikos%2C+Peter%3BBalis%2C+Frank+M&rft.aulast=Widemann&rft.aufirst=Brigitte&rft.date=2006-01-20&rft.volume=24&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2006-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Redefining the common insertion site. AN - 67618189; 16271739 AB - Retroviral mutagenesis has been used as a powerful tool to discover genes involved in oncogenesis through a technique called Common Insertion Site (CIS) analysis where tumors are induced by proviral integrations and the genomic loci of the proviruses are identified. A fundamental assumption made in this analysis is that multiple proviral insertions in close proximity occurring more frequently than would be predicted randomly provides evidence that the genes near the integrations are involved in the formation of the tumors. We demonstrate here using data derived from MLV integrations not put under selection for tumor induction that CIS analysis as currently defined is often not a sufficient argument for a gene's significance in tumorigenesis. JF - Virology AU - Wu, Xiaolin AU - Luke, Brian T AU - Burgess, Shawn M AD - Laboratory of Molecular Technology, Scientific Application International Corporation-Frederick, National Cancer Institute at Frederick, NIH, Frederick, MD, USA. Y1 - 2006/01/20/ PY - 2006 DA - 2006 Jan 20 SP - 292 EP - 295 VL - 344 IS - 2 SN - 0042-6822, 0042-6822 KW - Index Medicus KW - Leukemia Virus, Murine -- physiology KW - Leukemia Virus, Murine -- genetics KW - Humans KW - Models, Biological KW - Gene Expression Regulation -- genetics KW - Neoplasms -- virology KW - Neoplasms -- pathology KW - Recombination, Genetic -- genetics KW - Retroviridae -- physiology KW - Retroviridae -- genetics KW - Virus Integration -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67618189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Redefining+the+common+insertion+site.&rft.au=Wu%2C+Xiaolin%3BLuke%2C+Brian+T%3BBurgess%2C+Shawn+M&rft.aulast=Wu&rft.aufirst=Xiaolin&rft.date=2006-01-20&rft.volume=344&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity AN - 19771916; 6722688 AB - We demonstrate that the FATAL cytolysis assay can be adapted into a rapid and fluorometric antibody-dependent cellular cytotoxicity assay (RFADCC). The RFADCC relies on double-staining target cells with a membrane dye (PKH-26) and a viability dye (CFSE) prior to the addition of antibody and effector cells. We used the RFADCC to assess dose-dependent and envelope-specific anti-human immunodeficiency virus (HIV) ADCC responses mediated by monoclonal antibody-2G12 and human sera. Using the assay, we also detected early anti-simian immunodeficiency virus (SIV) ADCC responses in rhesus macaques infected with pathogenic SIV sub(m) sub(a) sub(c) sub(2) sub(5) sub(1). Importantly, the RFADCC was further useful in monitoring anti-HIV and anti-SIV ADCC responses elicited by immunizing chimpanzees and rhesus macaques with replicating adenovirus-based AIDS vaccine candidates. In comparison to the standard chromium release assay, the RFADCC provides a higher cell killing readout and is advantageous in allowing use of viably frozen as well as fresh effector cells, thus facilitating assay standardization. The RFADCC is therefore a simple, reliable, and highly sensitive method that can be applied to assess the ADCC activity of monoclonal antibodies as well as ADCC responses elicited by HIV or SIV infection or by AIDS vaccine candidates. cytotoxicity assay JF - Journal of Immunological Methods AU - Gomez-Roman, V R AU - Florese, R H AU - Patterson, L J AU - Peng, B AU - Venzon, D AU - Aldrich, K AU - Robert-Guroff, M AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Room D804, Bethesda, MD 20892-5065, United States, guroffm@mail.nih.gov Y1 - 2006/01/20/ PY - 2006 DA - 2006 Jan 20 SP - 53 EP - 67 PB - Elsevier B.V. VL - 308 IS - 1-2 SN - 0022-1759, 0022-1759 KW - HIV KW - Rhesus monkey KW - SIV KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Acquired immune deficiency syndrome KW - Chromium KW - Monoclonal antibodies KW - Infection KW - Pan troglodytes KW - Effector cells KW - Standardization KW - Cytotoxicity KW - Human immunodeficiency virus KW - Cytolysis KW - Macaca mulatta KW - Antibody-dependent cell-mediated cytotoxicity KW - Vaccines KW - Simian immunodeficiency virus KW - V 22360:AIDS and HIV KW - W3 33240:Immunology KW - W 30965:Miscellaneous, Reviews KW - F 06708:Other methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19771916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=A+simplified+method+for+the+rapid+fluorometric+assessment+of+antibody-dependent+cell-mediated+cytotoxicity&rft.au=Gomez-Roman%2C+V+R%3BFlorese%2C+R+H%3BPatterson%2C+L+J%3BPeng%2C+B%3BVenzon%2C+D%3BAldrich%2C+K%3BRobert-Guroff%2C+M&rft.aulast=Gomez-Roman&rft.aufirst=V&rft.date=2006-01-20&rft.volume=308&rft.issue=1-2&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2005.09.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Standardization; Cytotoxicity; Acquired immune deficiency syndrome; Chromium; Monoclonal antibodies; Cytolysis; Antibody-dependent cell-mediated cytotoxicity; Vaccines; Infection; Effector cells; Human immunodeficiency virus; Macaca mulatta; Simian immunodeficiency virus; Pan troglodytes DO - http://dx.doi.org/10.1016/j.jim.2005.09.018 ER - TY - CPAPER T1 - Identification and Characterization of Human Polycomb Response Elements T2 - 2006 Keystone Symposia on Epigenetics and Chromatin Remodeling in Development (A7) AN - 39825404; 4077979 JF - 2006 Keystone Symposia on Epigenetics and Chromatin Remodeling in Development (A7) AU - Zhao, Keji Y1 - 2006/01/19/ PY - 2006 DA - 2006 Jan 19 KW - Regulatory sequences KW - Polycomb group proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Epigenetics+and+Chromatin+Remodeling+in+Development+%28A7%29&rft.atitle=Identification+and+Characterization+of+Human+Polycomb+Response+Elements&rft.au=Zhao%2C+Keji&rft.aulast=Zhao&rft.aufirst=Keji&rft.date=2006-01-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Epigenetics+and+Chromatin+Remodeling+in+Development+%28A7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=784 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Who is at Risk of Melanoma? T2 - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AN - 39870124; 4052932 JF - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AU - Tucker, Margaret A Y1 - 2006/01/18/ PY - 2006 DA - 2006 Jan 18 KW - Melanoma KW - Risk assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.atitle=Who+is+at+Risk+of+Melanoma%3F&rft.au=Tucker%2C+Margaret+A&rft.aulast=Tucker&rft.aufirst=Margaret&rft.date=2006-01-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Trials of Antivascular Agents in Melanoma T2 - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AN - 39763670; 4052953 JF - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AU - Libutti, Steven K Y1 - 2006/01/18/ PY - 2006 DA - 2006 Jan 18 KW - Clinical trials KW - Melanoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39763670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.atitle=Clinical+Trials+of+Antivascular+Agents+in+Melanoma&rft.au=Libutti%2C+Steven+K&rft.aulast=Libutti&rft.aufirst=Steven&rft.date=2006-01-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Removal of Homeostatic Cytokine Sinks by Lymphodepletion Enhances the Efficacy of Adoptively Transferred Tumor-Specific CD8+ T Cells T2 - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AN - 39716974; 4052958 JF - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AU - Klebanoff, Christopher Austin Y1 - 2006/01/18/ PY - 2006 DA - 2006 Jan 18 KW - Cytokines KW - CD8 antigen KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39716974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.atitle=Removal+of+Homeostatic+Cytokine+Sinks+by+Lymphodepletion+Enhances+the+Efficacy+of+Adoptively+Transferred+Tumor-Specific+CD8%2B+T+Cells&rft.au=Klebanoff%2C+Christopher+Austin&rft.aulast=Klebanoff&rft.aufirst=Christopher&rft.date=2006-01-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Melanoma-Associated Genetic Mutations Targeted by Human CD4+ T Cells T2 - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AN - 39712021; 4052945 JF - 2006 Keystone Symposia on Advances in the Understanding and Treatment of Melanoma (A6) AU - Topalian, Suzanne L Y1 - 2006/01/18/ PY - 2006 DA - 2006 Jan 18 KW - Mutation KW - Lymphocytes T KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.atitle=Melanoma-Associated+Genetic+Mutations+Targeted+by+Human+CD4%2B+T+Cells&rft.au=Topalian%2C+Suzanne+L&rft.aulast=Topalian&rft.aufirst=Suzanne&rft.date=2006-01-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Advances+in+the+Understanding+and+Treatment+of+Melanoma+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hypoxia and Genetic Instability T2 - 2006 Keystone Symposia on Hypoxia and Development, Physiology and Disease (A5) AN - 39773260; 4053003 JF - 2006 Keystone Symposia on Hypoxia and Development, Physiology and Disease (A5) AU - Huang, L Eric Y1 - 2006/01/16/ PY - 2006 DA - 2006 Jan 16 KW - Hypoxia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Hypoxia+and+Development%2C+Physiology+and+Disease+%28A5%29&rft.atitle=Hypoxia+and+Genetic+Instability&rft.au=Huang%2C+L+Eric&rft.aulast=Huang&rft.aufirst=L&rft.date=2006-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Hypoxia+and+Development%2C+Physiology+and+Disease+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=783 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Small Molecule Inhibitors of HIF-1 T2 - 2006 Keystone Symposia on Hypoxia and Development, Physiology and Disease (A5) AN - 39759484; 4052981 JF - 2006 Keystone Symposia on Hypoxia and Development, Physiology and Disease (A5) AU - Melillo, Giovanni Y1 - 2006/01/16/ PY - 2006 DA - 2006 Jan 16 KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39759484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Hypoxia+and+Development%2C+Physiology+and+Disease+%28A5%29&rft.atitle=Novel+Small+Molecule+Inhibitors+of+HIF-1&rft.au=Melillo%2C+Giovanni&rft.aulast=Melillo&rft.aufirst=Giovanni&rft.date=2006-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Hypoxia+and+Development%2C+Physiology+and+Disease+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=783 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo. AN - 70697326; 16428508 AB - Epidermal growth factor receptor (EGFR) overexpression has been implicated in the development of head and neck squamous cell carcinomas (HNSCC) and represents a potential therapeutic target for this disease. We have reported previously that growth inhibitory concentrations of IFN-alpha enhance the expression and activity of EGFR and that this effect could represent an escape mechanism to the growth inhibition and apoptotic cell death induced by IFN-alpha. In this study, we investigate whether the combination of IFN-alpha and gefitinib (Iressa, AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom), a selective EGFR tyrosine kinase inhibitor, might have a cooperative antitumor effect on HNSCC-derived cell lines. The interaction of IFN-alpha and gefitinib was evaluated in vitro on HNSCC-derived cell lines by median drug effect analysis calculating a combination index with CalcuSyn software and in vivo by using HNSCC xenografts in nude mice. The mechanism of gefitinib and IFN-alpha interactions was also studied by analysis of cell cycle kinetics, apoptosis assays, and Western blotting of EGFR signal transduction components. Simultaneous exposure to gefitinib and IFN-alpha produced synergistic antiproliferative and proapoptotic effects compared with single drug treatment. Furthermore, daily treatment of gefitinib (50 mg/kg p.o.) in combination with an IFN-alpha regimen (50,000 units s.c. three times weekly) induced tumor growth delay and increased survival rate on established HNSCC xenografts in nude mice. Moreover, the concomitant treatment with gefitinib suppressed the stimulation of extracellular signal-regulated kinase phosphorylation/activity induced by IFN-alpha both in vitro and in vivo. The observed cooperative antitumor effects could be, at least in part, explained by the inhibition exerted by gefitinib of an IFN-alpha-induced EGF-dependent survival pathway, which involves extracellular signal-regulated kinase activation. These results provide a rationale for the clinical evaluation of gefitinib in combination with IFN-alpha in HNSCC. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bruzzese, Francesca AU - Di Gennaro, Elena AU - Avallone, Antonio AU - Pepe, Stefano AU - Arra, Claudio AU - Caraglia, Michele AU - Tagliaferri, Pierosandro AU - Budillon, Alfredo AD - Experimental Pharmacology Unit, Department of Experimental Oncology, National Cancer Institute G. Pascale, via M. Semmola, 80131 Naples, Italy. Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 617 EP - 625 VL - 12 IS - 2 SN - 1078-0432, 1078-0432 KW - Interferon-alpha KW - 0 KW - Quinazolines KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Interferon-alpha -- administration & dosage KW - Humans KW - Mice KW - Mice, Nude KW - Mice, Inbred BALB C KW - Quinazolines -- administration & dosage KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Tumor Cells, Cultured KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - In Vitro Techniques KW - Xenograft Model Antitumor Assays KW - Drug Synergism KW - Female KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Head and Neck Neoplasms -- metabolism KW - Head and Neck Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70697326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Synergistic+antitumor+activity+of+epidermal+growth+factor+receptor+tyrosine+kinase+inhibitor+gefitinib+and+IFN-alpha+in+head+and+neck+cancer+cells+in+vitro+and+in+vivo.&rft.au=Bruzzese%2C+Francesca%3BDi+Gennaro%2C+Elena%3BAvallone%2C+Antonio%3BPepe%2C+Stefano%3BArra%2C+Claudio%3BCaraglia%2C+Michele%3BTagliaferri%2C+Pierosandro%3BBudillon%2C+Alfredo&rft.aulast=Bruzzese&rft.aufirst=Francesca&rft.date=2006-01-15&rft.volume=12&rft.issue=2&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age-related changes of the cervix influence human papillomavirus type distribution. AN - 70686331; 16424061 AB - Approximately 15 human papillomavirus (HPV) types cause virtually all cervical cancer whereas other HPV types are unrelated to cancer. We were interested in whether some noncarcinogenic types differ from carcinogenic in their affinity for the cervical transformation zone, where nearly all HPV-induced cancers occur. To examine this possibility, we tested cervical specimens from 8,374 women without cervical precancer and cancer participating in a population-based study in Guanacaste for >40 HPV types using PCR. We compared age-group specific prevalences of HPV types of the alpha9 species, which are mainly carcinogenic and include HPV16, to the genetically distinct types of the alpha3/alpha15 species (e.g., HPV71), which are noncarcinogenic and common in vaginal specimens from hysterectomized women. We related HPV detection of each group to the location of the junction between the squamous epithelium of the ectocervix and vagina and the columnar epithelium of the endocervical canal. Models evaluated the independent effects of amount of exposed columnar epithelium (ectopy) and age on the presence of alpha9 or alpha3/alpha15 types. Prevalence of alpha9 types (7.6%) peaked in the youngest women, declined in middle-aged women, and then increased slightly in older women. By contrast, prevalence of alpha3/alpha15 types (7.6%) tended to remain invariant or to increase with increasing age. Detection of alpha9 infections increased (P(trend) < 0.0005) but alpha3/alpha15 infections decreased (P(trend) < 0.0005) with increasing exposure of the columnar epithelia. Older age and decreasing cervical ectopy were independently positively associated with having an alpha3/alpha15 infection compared with having an alpha9 infection. These patterns need to be confirmed in other studies and populations. We suggest that these genetically distinct groups of HPV types may differ in tissue preferences, which may contribute to their differences in carcinogenic potential. JF - Cancer research AU - Castle, Philip E AU - Jeronimo, Jose AU - Schiffman, Mark AU - Herrero, Rolando AU - Rodríguez, Ana C AU - Bratti, M Concepción AU - Hildesheim, Allan AU - Wacholder, Sholom AU - Long, L Rodney AU - Neve, Leif AU - Pfeiffer, Ruth AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute/NIH, 6120 Executive Boulevard, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 1218 EP - 1224 VL - 66 IS - 2 SN - 0008-5472, 0008-5472 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Age Factors KW - Precancerous Conditions KW - Humans KW - Aged KW - Polymerase Chain Reaction KW - Hysterectomy KW - DNA, Viral -- analysis KW - Epidemiologic Studies KW - Adult KW - Vagina -- virology KW - Middle Aged KW - Costa Rica -- epidemiology KW - Cell Transformation, Neoplastic KW - Female KW - Prevalence KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- pathogenicity KW - Papillomavirus Infections -- complications KW - Papillomaviridae -- genetics KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70686331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Age-related+changes+of+the+cervix+influence+human+papillomavirus+type+distribution.&rft.au=Castle%2C+Philip+E%3BJeronimo%2C+Jose%3BSchiffman%2C+Mark%3BHerrero%2C+Rolando%3BRodr%C3%ADguez%2C+Ana+C%3BBratti%2C+M+Concepci%C3%B3n%3BHildesheim%2C+Allan%3BWacholder%2C+Sholom%3BLong%2C+L+Rodney%3BNeve%2C+Leif%3BPfeiffer%2C+Ruth%3BBurk%2C+Robert+D&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2006-01-15&rft.volume=66&rft.issue=2&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-14 N1 - Date created - 2006-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model. AN - 70664812; 16424047 AB - Recent studies suggest that immunotherapy targeting specific tumor-associated antigens (TAAs) may be beneficial in cancer patients. However, most of these TAAs are tumor type specific and heterogeneous among patients, thus limiting their applications. Here, we describe the de novo induction of a cancer/testis antigen (CTA) for immunotherapy of tumors of various histologies. The murine CTA P1A, normally expressed only in a few tumor lines, could be induced de novo in all P1A-negative cancer lines of eight histologic origins in vitro and in various murine xenografts by systemic administration of 5-aza-2'-deoxycytidine. The induction of P1A expression correlated strongly with demethylation of the CpG island in the promoter region of this gene. The induced antigen was processed and presented properly for recognition by H-2L(d)-restricted P1A-specific CTLs. The combination of a demethylating agent and adoptive transfer of P1A-specific CTL effectively treated lung metastases in syngeneic mice challenged with P1A-negative 4T1 mammary carcinoma cells. These data show a novel strategy of combined chemoimmunotherapy of cancer targeting a CTA induced de novo in a broad range of tumor histologies, and support further evaluation of chromatin-remodeling agents for human cancer therapy. JF - Cancer research AU - Guo, Z Sheng AU - Hong, Julie A AU - Irvine, Kari R AU - Chen, G Aaron AU - Spiess, Paul J AU - Liu, Yang AU - Zeng, Gang AU - Wunderlich, John R AU - Nguyen, Dao M AU - Restifo, Nicholas P AU - Schrump, David S AD - Thoracic Oncology Section and Tumor Immunology Section, Surgery Branch, National Cancer Institute/NIH, Bethesda, MD 20892, USA. guozs@upmc.edu Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 1105 EP - 1113 VL - 66 IS - 2 SN - 0008-5472, 0008-5472 KW - Antigens, Neoplasm KW - 0 KW - Antimetabolites, Antineoplastic KW - Chromatin KW - cancer-testis antigen P1A, mouse KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Chromatin -- metabolism KW - Mammary Neoplasms, Animal -- pathology KW - Humans KW - Lung Neoplasms -- immunology KW - Lung Neoplasms -- secondary KW - Mammary Neoplasms, Animal -- immunology KW - Lung Neoplasms -- therapy KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Neoplasms -- therapy KW - Gene Expression Profiling KW - Tumor Cells, Cultured KW - DNA Methylation KW - CpG Islands KW - Transplantation, Heterologous KW - Mammary Neoplasms, Animal -- therapy KW - Neoplasms -- immunology KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Antigens, Neoplasm -- biosynthesis KW - Immunotherapy, Adoptive KW - Antimetabolites, Antineoplastic -- pharmacology KW - Antigens, Neoplasm -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70664812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=De+novo+induction+of+a+cancer%2Ftestis+antigen+by+5-aza-2%27-deoxycytidine+augments+adoptive+immunotherapy+in+a+murine+tumor+model.&rft.au=Guo%2C+Z+Sheng%3BHong%2C+Julie+A%3BIrvine%2C+Kari+R%3BChen%2C+G+Aaron%3BSpiess%2C+Paul+J%3BLiu%2C+Yang%3BZeng%2C+Gang%3BWunderlich%2C+John+R%3BNguyen%2C+Dao+M%3BRestifo%2C+Nicholas+P%3BSchrump%2C+David+S&rft.aulast=Guo&rft.aufirst=Z&rft.date=2006-01-15&rft.volume=66&rft.issue=2&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-14 N1 - Date created - 2006-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunol Rev. 1999 Aug;170:85-100 [10566144] J Immunol Methods. 2000 Jul 31;241(1-2):121-9 [10915854] Ann Thorac Surg. 2001 Jan;71(1):295-301; 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author reply 2901-2 [17363616] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Chemokines in CD4+ T Cell Memory T2 - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AN - 39893096; 4078174 JF - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AU - Farber, Joshua M Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 KW - Memory cells KW - Lymphocytes T KW - CD4 antigen KW - Chemokines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.atitle=Chemokines+in+CD4%2B+T+Cell+Memory&rft.au=Farber%2C+Joshua+M&rft.aulast=Farber&rft.aufirst=Joshua&rft.date=2006-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidized LDL Metabolites Upregulate Expression and Function of Monocyte CX3CR1 through a PPARgamma-dependent Pathway T2 - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AN - 39820586; 4078185 JF - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AU - Barlic, Jana Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 KW - Metabolites KW - Monocytes KW - Lipoproteins (low density) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.atitle=Oxidized+LDL+Metabolites+Upregulate+Expression+and+Function+of+Monocyte+CX3CR1+through+a+PPARgamma-dependent+Pathway&rft.au=Barlic%2C+Jana&rft.aulast=Barlic&rft.aufirst=Jana&rft.date=2006-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alarmins are Non-Cognate Chemokine Receptor Ligands and Activators of Dendritic Cells T2 - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AN - 39796627; 4078177 JF - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AU - Oppenheim, Joost J Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 KW - Dendritic cells KW - Chemokine receptors KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39796627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.atitle=Alarmins+are+Non-Cognate+Chemokine+Receptor+Ligands+and+Activators+of+Dendritic+Cells&rft.au=Oppenheim%2C+Joost+J&rft.aulast=Oppenheim&rft.aufirst=Joost&rft.date=2006-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemokine Receptor CCR5 Mediates Resistance to West Nile Virus Infection in Mouse and Man T2 - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AN - 39765821; 4078219 JF - 2006 Keystone Symposia on Chemokines and Chemokine Receptors (A4) AU - Lim, Jean K Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 KW - Infection KW - Chemokine receptors KW - CCR5 protein KW - West Nile virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39765821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.atitle=Chemokine+Receptor+CCR5+Mediates+Resistance+to+West+Nile+Virus+Infection+in+Mouse+and+Man&rft.au=Lim%2C+Jean+K&rft.aulast=Lim&rft.aufirst=Jean&rft.date=2006-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Preexposure to Live Brugia malayi Microfilariae Alters the Innate Response of Human Dendritic Cells to Mycobacterium tuberculosis AN - 17470258; 6677812 AB - Mycobacterium tuberculosis and helminth coinfection is highly prevalent, and the presence of helminths may modulate the Th1 response necessary for M. tuberculosis control. Elutriated human monocytes, differentiated into dendritic cells (DCs) and macrophages, were exposed in vitro to live microfilariae (mf). The influence that mf had on M. tuberculosis infectivity, expression of cell surface molecules, and production of cytokines was determined.Compared with mf-unexposed, M. tuberculosis-infected cells, mf-exposed, M. tuberculosis-infected DCs had decreased expression of CD14, CD54, and human leukocyte antigen-DR, and mf-exposed, M. tuberculosis-infected macrophages had decreased expression of CD40. DCs that were mf exposed and M. tuberculosis infected produced more interleukin (IL)-1 beta than did mf-unexposed, M. tuberculosis-infected DCs. Also, mf-exposed, M. tuberculosis-infected DCs and macrophages expressed less IL-10 and interferon (IFN)- alpha than did mf-unexposed, M. tuberculosis-infected cells. When they were cultured with autologous CD4 super(+) T cells, mf-exposed, M. tuberculosis-infected DCs were less capable of stimulating the production of IFN- gamma than were other DCs. Exposure of DCs to mf decreased the surface expression of DC-specific intercellular adhesion molecule-3 grabbing nonintegrin, a receptor required by M. tuberculosis for entry into DCs. Exposure to mf reduces a key receptor on the DC surface, which perhaps renders these cells less susceptible to infection with M. tuberculosis. Exposure to mf changes the surface expression of adhesion and costimulatory molecules on DCs and macrophages and alters their expression of cytokines and chemokines in a way that renders them less capable of immunologic responses. JF - Journal of Infectious Diseases AU - Talaat, K R AU - Bonawitz, R E AU - Domenech, P AU - Nutman, T B AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 196 EP - 204 VL - 193 IS - 2 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Chemokines KW - Helper cells KW - Leukocytes KW - CD14 antigen KW - Dendritic cells KW - CD4 antigen KW - Brugia malayi KW - Lymphocytes T KW - Cytokines KW - Tuberculosis KW - Monocytes KW - CD40 antigen KW - Mycobacterium tuberculosis KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17470258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Preexposure+to+Live+Brugia+malayi+Microfilariae+Alters+the+Innate+Response+of+Human+Dendritic+Cells+to+Mycobacterium+tuberculosis&rft.au=Talaat%2C+K+R%3BBonawitz%2C+R+E%3BDomenech%2C+P%3BNutman%2C+T+B&rft.aulast=Talaat&rft.aufirst=K&rft.date=2006-01-15&rft.volume=193&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Dendritic cells; Chemokines; CD4 antigen; Helper cells; Leukocytes; Lymphocytes T; Cytokines; Tuberculosis; Monocytes; CD14 antigen; CD40 antigen; Brugia malayi; Mycobacterium tuberculosis ER - TY - JOUR T1 - Encoding a motor memory in the older adult by action observation AN - 17467586; 6654093 AB - The ability of motor training to encode a motor memory is reduced in older adults. Here, we tested the hypothesis that training-dependent memory encoding, an issue of relevance in neurorehabilitation, is enhanced in elder individuals by action observation which alone can contribute to learning processes. A group of 11 healthy older adults participated in this study, which consisted of three randomized counterbalanced sessions on different days testing the effects of motor training (MT) alone, action observation (AO) alone, and a combination of both (MT + AO) on motor memory encoding. The combination of MT + AO formed a motor memory in the primary motor cortex and differentially modulated motor cortical excitability in muscles that were agonist and antagonist with respect to the training task, but MT or AO alone did not. These results suggest that action observation can enhance the effects of motor training on memory encoding protocols in the older adult, possibly through Hebbian modulation of intracortical excitatory mechanisms. JF - NeuroImage AU - Celnik, Pablo AU - Stefan, Katja AU - Hummel, Friedhelm AU - Duque, Julie AU - Classen, Joseph AU - Cohen, Leonardo G AD - Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, cohenl@ninds.nih.gov Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 677 EP - 684 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 29 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Cortex (motor) KW - Learning KW - Muscles KW - Excitability KW - Neuromodulation KW - Memory KW - Information processing KW - N3 11046:Memory and learning KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Encoding+a+motor+memory+in+the+older+adult+by+action+observation&rft.au=Celnik%2C+Pablo%3BStefan%2C+Katja%3BHummel%2C+Friedhelm%3BDuque%2C+Julie%3BClassen%2C+Joseph%3BCohen%2C+Leonardo+G&rft.aulast=Celnik&rft.aufirst=Pablo&rft.date=2006-01-15&rft.volume=29&rft.issue=2&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.07.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Memory; Information processing; Learning; Neuromodulation; Muscles; Excitability; Cortex (motor) DO - http://dx.doi.org/10.1016/j.neuroimage.2005.07.039 ER - TY - JOUR T1 - Dynamic modulation of the primary somatosensory cortex during seeing and feeling a touched hand AN - 17462975; 6654082 AB - Previous work has demonstrated cross-modal links between vision and somatosensation at an early stage of sensory processing. Furthermore, recent behavioral studies have shown that viewing the stimulated body part can enhance tactile discrimination ability at the stimulated site. This study aims to investigate the role of the primary somatosensory cortex (SI) during visuotactile integration processes. Subjects looked at a hand in a video being touched on the first digit (D1) in synchrony with felt touches on their real hidden hand as compared with watching a video with asynchronous touches. During synchronous stimulation, subjects reported to feel the tactile sensation on the video hand, thus indicating that in this condition the subjects regarded the video hand as their own touched hand. This feeling disappeared in the asynchronous condition. Using neuromagnetic source imaging, we assessed the topography of the functional organization of SI related to tactile stimulation of D1. The cortical representation of D1 moved to a more inferior location during synchronous in comparison to asynchronous stimulation and rest. This modulation of the map in SI was significantly positively correlated with the feeling that the seen touch in the video represented the touch on the real hand. Thus, only if the seen touch is attributed to the own body, SI seems to be modulated. JF - NeuroImage AU - Schaefer, Michael AU - Flor, Herta AU - Heinze, Hans-Jochen AU - Rotte, Michael AD - Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, schaefem@ninds.nih.gov Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 587 EP - 592 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 29 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Hand KW - Neuromodulation KW - Vision KW - Information processing KW - Sensory integration KW - Functional morphology KW - Tactile discrimination KW - Cortex (somatosensory) KW - Topography KW - W 30910:Imaging KW - N3 11013:Somatosensory systems (except pain) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17462975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dynamic+modulation+of+the+primary+somatosensory+cortex+during+seeing+and+feeling+a+touched+hand&rft.au=Schaefer%2C+Michael%3BFlor%2C+Herta%3BHeinze%2C+Hans-Jochen%3BRotte%2C+Michael&rft.aulast=Schaefer&rft.aufirst=Michael&rft.date=2006-01-15&rft.volume=29&rft.issue=2&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.07.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hand; Cortex (somatosensory); Neuromodulation; Sensory integration; Topography; Tactile discrimination; Functional morphology; Neuroimaging; Information processing; Vision DO - http://dx.doi.org/10.1016/j.neuroimage.2005.07.016 ER - TY - JOUR T1 - The role of the dorsal stream for gesture production AN - 17460657; 6654065 AB - Skilled gestures require the integrity of the neural networks involved in storage, retrieval, and execution of motor programs. Premotor cortex and/or parietal cortex lesions frequently produce deficits during performance of gestures, transitive more than intransitive. The dorsal stream links object information with object action, suggesting that mechanical knowledge of tool use is stored focally in the brain. Using event-related fMRI, we explored activity during instructed-delay transitive and intransitive hand gestures. The comparison between planning-preparation and execution of gestures demonstrated a temporal rostral to caudal gradient of activation in the ventral premotor cortex (PMv) and inferior to superior gradient of activation in the posterior parietal cortex (PPc). Comparison between transitive and intransitive gestures established a functional specificity within the dorsal stream for mechanical knowledge. Results demonstrate that not only PPc but also the PMv acts in the processing of sensorimotor information during gestures. This might be the substrate underlying selective deficits in ideomotor apraxia patients. JF - NeuroImage AU - Fridman, Esteban A AU - Immisch, Ilka AU - Hanakawa, Takashi AU - Bohlhalter, Stephan AU - Waldvogel, Daniel AU - Kansaku, Kenji AU - Wheaton, Lewis AU - Wu, Tao AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 10, Rm. 5N226, 10 Center Drive, MSC-1438, Bethesda, MD 20892-1428, USA, hallettm@ninds.nih.gov Y1 - 2006/01/15/ PY - 2006 DA - 2006 Jan 15 SP - 417 EP - 428 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 29 IS - 2 SN - 1053-8119, 1053-8119 KW - apraxia KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Motor skill KW - Tool use KW - Neural networks KW - Functional magnetic resonance imaging KW - Brain KW - Hand KW - Sensorimotor integration KW - Cortex KW - Information processing KW - W 30910:Imaging KW - N3 11011:Motor systems and movement disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17460657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+role+of+the+dorsal+stream+for+gesture+production&rft.au=Fridman%2C+Esteban+A%3BImmisch%2C+Ilka%3BHanakawa%2C+Takashi%3BBohlhalter%2C+Stephan%3BWaldvogel%2C+Daniel%3BKansaku%2C+Kenji%3BWheaton%2C+Lewis%3BWu%2C+Tao%3BHallett%2C+Mark&rft.aulast=Fridman&rft.aufirst=Esteban&rft.date=2006-01-15&rft.volume=29&rft.issue=2&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.07.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cortex; Motor skill; Information processing; Neural networks; Sensorimotor integration; Brain; Tool use; Hand; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2005.07.026 ER - TY - CPAPER T1 - Polymerase Infidelity as a Source of Genomic Mutations T2 - XIV Conference on Plant and Animal Genome AN - 39805595; 4056167 JF - XIV Conference on Plant and Animal Genome AU - Bebenek, Katarzyna Y1 - 2006/01/14/ PY - 2006 DA - 2006 Jan 14 KW - Mutation KW - Genomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39805595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XIV+Conference+on+Plant+and+Animal+Genome&rft.atitle=Polymerase+Infidelity+as+a+Source+of+Genomic+Mutations&rft.au=Bebenek%2C+Katarzyna&rft.aulast=Bebenek&rft.aufirst=Katarzyna&rft.date=2006-01-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XIV+Conference+on+Plant+and+Animal+Genome&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/14/14-workshops.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase. AN - 70697990; 16278211 AB - ADP-ribosylation is a post-translational modification resulting from transfer of the ADP-ribose moiety of NAD to protein. Mammalian cells contain mono-ADP-ribosyltransferases that catalyze the formation of ADP-ribose-(arginine) protein, which can be cleaved by a 39-kDa ADP-ribose-(arginine) protein hydrolase (ARH1), resulting in release of free ADP-ribose and regeneration of unmodified protein. Enzymes involved in poly(ADP-ribosylation) participate in several critical physiological processes, including DNA repair, cellular differentiation, and carcinogenesis. Multiple poly(ADP-ribose) polymerases have been identified in the human genome, but there is only one known poly(ADP-ribose) glycohydrolase (PARG), a 111-kDa protein that degrades the (ADP-ribose) polymer to ADP-ribose. We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. The 39-kDa ARH3 shares amino acid sequence identity with both ARH1 and the catalytic domain of PARG. ARH3 activity, like that of ARH1, was enhanced by Mg(2+). Critical vicinal acidic amino acids in ARH3, identified by mutagenesis (Asp(77) and Asp(78)), are located in a region similar to that required for activity in ARH1 but different from the location of the critical vicinal glutamates in the PARG catalytic site. All findings are consistent with the conclusion that ARH3 has PARG activity but is structurally unrelated to PARG. JF - The Journal of biological chemistry AU - Oka, Shunya AU - Kato, Jiro AU - Moss, Joel AD - Pulmonary-Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892-1590, USA. Y1 - 2006/01/13/ PY - 2006 DA - 2006 Jan 13 SP - 705 EP - 713 VL - 281 IS - 2 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - RNA, Messenger KW - Recombinant Proteins KW - Ribose KW - 681HV46001 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Glycoside Hydrolases KW - EC 3.2.1.- KW - ADPRHL2 protein, human KW - EC 3.2.1.143 KW - poly ADP-ribose glycohydrolase KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - ARH1 protein, mouse KW - EC 3.2.2.19 KW - Magnesium KW - I38ZP9992A KW - Dithiothreitol KW - T8ID5YZU6Y KW - Index Medicus KW - Animals KW - Humans KW - Thymus Gland -- metabolism KW - Catalytic Domain KW - Nucleic Acid Hybridization KW - Autoradiography KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Chromatography, High Pressure Liquid KW - Mutagenesis KW - Molecular Sequence Data KW - Recombinant Proteins -- chemistry KW - Sequence Homology, Amino Acid KW - Time Factors KW - Magnesium -- chemistry KW - Amino Acid Sequence KW - Mice KW - Hydrolysis KW - Cattle KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Ribose -- chemistry KW - Dithiothreitol -- pharmacology KW - Mice, Inbred C57BL KW - Mutation KW - Cell Line KW - DNA Primers -- chemistry KW - Glycoside Hydrolases -- physiology KW - Glycoside Hydrolases -- chemistry KW - N-Glycosyl Hydrolases -- genetics KW - N-Glycosyl Hydrolases -- metabolism KW - Glycoside Hydrolases -- metabolism KW - N-Glycosyl Hydrolases -- chemistry KW - Glycoside Hydrolases -- genetics KW - N-Glycosyl Hydrolases -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70697990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+and+characterization+of+a+mammalian+39-kDa+poly%28ADP-ribose%29+glycohydrolase.&rft.au=Oka%2C+Shunya%3BKato%2C+Jiro%3BMoss%2C+Joel&rft.aulast=Oka&rft.aufirst=Shunya&rft.date=2006-01-13&rft.volume=281&rft.issue=2&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Complementary and Alternative Medicine (CAM) and Cancer Prognosis T2 - 2006 Special Conference on New Developments in the Epidemiology of Cancer Prognosis: Traditional and Molecular Predictors of Treatment Response and Survival AN - 39927087; 4153363 JF - 2006 Special Conference on New Developments in the Epidemiology of Cancer Prognosis: Traditional and Molecular Predictors of Treatment Response and Survival AU - White, Jeffrey D Y1 - 2006/01/11/ PY - 2006 DA - 2006 Jan 11 KW - Cancer KW - Prognosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Special+Conference+on+New+Developments+in+the+Epidemiology+of+Cancer+Prognosis%3A+Traditional+and+Molecular+Predictors+of+Treatment+Response+and+Survival&rft.atitle=Complementary+and+Alternative+Medicine+%28CAM%29+and+Cancer+Prognosis&rft.au=White%2C+Jeffrey+D&rft.aulast=White&rft.aufirst=Jeffrey&rft.date=2006-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Special+Conference+on+New+Developments+in+the+Epidemiology+of+Cancer+Prognosis%3A+Traditional+and+Molecular+Predictors+of+Treatment+Response+and+Survival&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/pdf_files/2006Prognosis/Prog nosis06_final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: the Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study. AN - 67642577; 16398939 AB - Carboplatin/paclitaxel is the chemotherapy of choice for advanced ovarian cancer, both in first line and in platinum-sensitive recurrence. Although a significant proportion of patients have some neurotoxicity during treatment, the long-term outcome of chemotherapy-induced neuropathy has been scantly studied. We retrospectively assessed the prevalence of residual neuropathy in a cohort of patients in clinical remission after first-line carboplatin/paclitaxel for advanced ovarian cancer. 120 patients have been included in this study (101 participating in a multicentre phase III trial evaluating the efficacy of consolidation treatment with topotecan, and 19 treated at the National Cancer Institute of Naples after the end of the trial). All patients received carboplatin (AUC 5) plus paclitaxel (175 mg/m2) every 3 weeks for 6 cycles, completing treatment between 1998 and 2003. Data were collected between May and September 2004. Residual sensory and motor neurotoxicity were coded according to the National Cancer Institute--Common Toxicity Criteria. 55 patients (46%) did not experience any grade of neurological toxicity during chemotherapy and of these none had signs of neuropathy during follow-up. The other 65 patients (54%) had chemotherapy-induced neurotoxicity during treatment and follow-up data are available for 60 of them. Fourteen out of 60 patients (23%) referred residual neuropathy at the most recent follow-up visit, after a median follow up of 18 months (range, 7-58 months): 12 patients had grade 1 and 2 patients grade 2 peripheral sensory neuropathy; 3 patients also had grade 1 motor neuropathy. The remaining 46/60 patients (77%) had no residual neuropathy at the moment of interview: recovery from neurotoxicity had occurred in the first 2 months after the end of chemotherapy in 22 (37%), between 2 and 6 months in 15 (25%), or after more than 6 months in 9 patients (15%). Considering all 120 treated patients, there was a 15% probability of persistent neurological toxicity 6 months after the end of chemotherapy. A significant proportion of patients with advanced ovarian cancer treated with first-line carboplatin/paclitaxel suffer long-term residual neuropathy. This issue should be carefully taken into account before considering re-treatment with the same agents in sensitive recurrent disease. JF - BMC cancer AU - Pignata, Sandro AU - De Placido, Sabino AU - Biamonte, Rosalbino AU - Scambia, Giovanni AU - Di Vagno, Giovanni AU - Colucci, Giuseppe AU - Febbraro, Antonio AU - Marinaccio, Marco AU - Lombardi, Alessandra Vernaglia AU - Manzione, Luigi AU - Cartenì, Giacomo AU - Nardi, Mario AU - Danese, Saverio AU - Valerio, Maria Rosaria AU - de Matteis, Andrea AU - Massidda, Bruno AU - Gasparini, Giampietro AU - Di Maio, Massimo AU - Pisano, Carmela AU - Perrone, Francesco AD - Medical Oncology B, National Cancer Institute, Naples, Italy. sandro.pignata@fondazionepascale.it Y1 - 2006/01/07/ PY - 2006 DA - 2006 Jan 07 SP - 5 VL - 6 KW - Topotecan KW - 7M7YKX2N15 KW - Carboplatin KW - BG3F62OND5 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Severity of Illness Index KW - Paclitaxel -- administration & dosage KW - Humans KW - Adult KW - Topotecan -- administration & dosage KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Time Factors KW - Carboplatin -- administration & dosage KW - Female KW - Ovarian Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Peripheral Nervous System Diseases -- chemically induced KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67642577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Residual+neurotoxicity+in+ovarian+cancer+patients+in+clinical+remission+after+first-line+chemotherapy+with+carboplatin+and+paclitaxel%3A+the+Multicenter+Italian+Trial+in+Ovarian+cancer+%28MITO-4%29+retrospective+study.&rft.au=Pignata%2C+Sandro%3BDe+Placido%2C+Sabino%3BBiamonte%2C+Rosalbino%3BScambia%2C+Giovanni%3BDi+Vagno%2C+Giovanni%3BColucci%2C+Giuseppe%3BFebbraro%2C+Antonio%3BMarinaccio%2C+Marco%3BLombardi%2C+Alessandra+Vernaglia%3BManzione%2C+Luigi%3BCarten%C3%AC%2C+Giacomo%3BNardi%2C+Mario%3BDanese%2C+Saverio%3BValerio%2C+Maria+Rosaria%3Bde+Matteis%2C+Andrea%3BMassidda%2C+Bruno%3BGasparini%2C+Giampietro%3BDi+Maio%2C+Massimo%3BPisano%2C+Carmela%3BPerrone%2C+Francesco&rft.aulast=Pignata&rft.aufirst=Sandro&rft.date=2006-01-07&rft.volume=6&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Cancer. 2003 Jul;39(10):1402-8 [12826043] J Clin Oncol. 2003 May 1;21(9):1767-74 [12721253] J Clin Oncol. 2003 Jul 1;21(13):2460-5 [12829663] Ann Oncol. 2003 Jul;14(7):1086-93 [12853351] J Clin Oncol. 2003 Sep 1;21(17):3194-200 [12860964] J Natl Cancer Inst. 2003 Sep 3;95(17):1320-9 [12953086] Clin Cancer Res. 2003 Nov 15;9(15):5756-67 [14654561] Breast Cancer. 2004;11(1):92-9 [14718800] J Clin Oncol. 2004 Jun 15;22(12):2461-8 [15197209] J Clin Oncol. 2004 Jul 1;22(13):2635-42 [15226331] Anticancer Res. 2004 Jul-Aug;24(4):2337-41 [15330181] Cancer. 1995 Sep 1;76(5):916-7 [8625200] J Natl Cancer Inst. 2004 Nov 17;96(22):1682-91 [15547181] J Clin Oncol. 2000 Sep;18(17):3084-92 [10963636] J Cancer Res Clin Oncol. 2001 Jan;127(1):55-8 [11206272] Lancet. 2003 Jun 21;361(9375):2099-106 [12826431] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resveratrol improves health and survival of mice on a high-calorie diet AN - 907160183; 14935916 AB - Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor- gamma coactivator 1 alpha (PGC-1 alpha ) activity, increased mitochondrial number, and improved motor function. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing. JF - Nature AU - Baur, Joseph A AU - Pearson, Kevin J AU - Price, Nathan L AU - Jamieson, Hamish A AU - Lerin, Carles AU - Kalra, Avash AU - Prabhu, Vinayakumar V AU - Allard, Joanne S AU - Lopez-Lluch, Guillermo AU - Lewis, Kaitlyn AU - Pistell, Paul J AU - Poosala, Suresh AU - Becker, Kevin G AU - Boss, Olivier AU - Gwinn, Dana AU - Wang, Mingyi AU - Ramaswamy, Sharan AU - Fishbein, Kenneth W AU - Spencer, Richard G AU - Lakatta, Edward G AU - Le Couteur, David AU - Shaw, Reuben J AU - Navas, Placido AU - Puigserver, Pere AU - Ingram, Donald K AU - de Cabo, Rafael AU - Sinclair, David A AD - Laboratory of Clinical Investigation, Research Resources Branch of the Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA PY - 2006 SP - 337 EP - 342 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 444 IS - 7117 SN - 0028-0836, 0028-0836 KW - Ecology Abstracts KW - Diets KW - Insulin-like growth factor I KW - Data processing KW - Peroxisome proliferator-activated receptors KW - Dietary restrictions KW - Aging KW - Life span KW - Mitochondria KW - Survival KW - Insulin KW - Saccharomyces cerevisiae KW - Resveratrol KW - Caenorhabditis elegans KW - Drosophila melanogaster KW - AMP-activated protein kinase KW - PGC-1 protein KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907160183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Resveratrol+improves+health+and+survival+of+mice+on+a+high-calorie+diet&rft.au=Baur%2C+Joseph+A%3BPearson%2C+Kevin+J%3BPrice%2C+Nathan+L%3BJamieson%2C+Hamish+A%3BLerin%2C+Carles%3BKalra%2C+Avash%3BPrabhu%2C+Vinayakumar+V%3BAllard%2C+Joanne+S%3BLopez-Lluch%2C+Guillermo%3BLewis%2C+Kaitlyn%3BPistell%2C+Paul+J%3BPoosala%2C+Suresh%3BBecker%2C+Kevin+G%3BBoss%2C+Olivier%3BGwinn%2C+Dana%3BWang%2C+Mingyi%3BRamaswamy%2C+Sharan%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G%3BLakatta%2C+Edward+G%3BLe+Couteur%2C+David%3BShaw%2C+Reuben+J%3BNavas%2C+Placido%3BPuigserver%2C+Pere%3BIngram%2C+Donald+K%3Bde+Cabo%2C+Rafael%3BSinclair%2C+David+A&rft.aulast=Baur&rft.aufirst=Joseph&rft.date=2006-01-06&rft.volume=444&rft.issue=7117&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature05354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Diets; Insulin-like growth factor I; Data processing; Peroxisome proliferator-activated receptors; Dietary restrictions; Life span; Aging; Survival; Mitochondria; Insulin; Resveratrol; AMP-activated protein kinase; PGC-1 protein; Drosophila melanogaster; Caenorhabditis elegans; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1038/nature05354 ER - TY - JOUR T1 - Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop. AN - 70685851; 16257967 AB - Integration is essential for retroviral replication and gene therapy using retroviral vectors. Human immunodeficiency virus, type 1 (HIV-1), integrase specifically recognizes the terminal sequences of each long terminal repeat (LTR) and cleaves the 3'-end terminal dinucleotide 5'-GT. The exposed 3'-hydroxyl is then positioned for nucleophilic attack and subsequent strand transfer into another DNA duplex (target or chromosomal DNA). We report that both the terminal cytosine at the protruding 5'-end of the long terminal repeats (5'-C) and the integrase residue Gln-148 are critical for strand transfer. Proximity of the 5'-C and Gln-148 was demonstrated by disulfide cross-linking. Cross-linking is inhibited by the inhibitor 5CITEP 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone. We propose that strand transfer requires a conformational change of the integrase-viral (donor) DNA complex with formation of an H-bond between the N-3 of the 5'-C and the amine group of Gln-148. These findings have implications for the molecular mechanisms coupling 3'-processing and strand transfer as well as for the molecular pharmacology of integrase inhibitors. JF - The Journal of biological chemistry AU - Johnson, Allison A AU - Santos, Webster AU - Pais, Godwin C G AU - Marchand, Christophe AU - Amin, Ronak AU - Burke, Terrence R AU - Verdine, Gregory AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 SP - 461 EP - 467 VL - 281 IS - 1 SN - 0021-9258, 0021-9258 KW - Glutamine KW - 0RH81L854J KW - Cytosine KW - 8J337D1HZY KW - HIV Integrase KW - EC 2.7.7.- KW - Index Medicus KW - Virus Replication KW - Protein Structure, Secondary KW - Cytosine -- chemistry KW - Conserved Sequence KW - Glutamine -- chemistry KW - Substrate Specificity KW - Virus Integration KW - Hydrogen Bonding KW - Mutagenesis KW - HIV-1 -- genetics KW - HIV Integrase -- genetics KW - HIV-1 -- growth & development KW - HIV-1 -- enzymology KW - HIV Long Terminal Repeat -- physiology KW - HIV Integrase -- chemistry KW - HIV Integrase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70685851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Integration+requires+a+specific+interaction+of+the+donor+DNA+terminal+5%27-cytosine+with+glutamine+148+of+the+HIV-1+integrase+flexible+loop.&rft.au=Johnson%2C+Allison+A%3BSantos%2C+Webster%3BPais%2C+Godwin+C+G%3BMarchand%2C+Christophe%3BAmin%2C+Ronak%3BBurke%2C+Terrence+R%3BVerdine%2C+Gregory%3BPommier%2C+Yves&rft.aulast=Johnson&rft.aufirst=Allison&rft.date=2006-01-06&rft.volume=281&rft.issue=1&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Host Responses to Avian Influenza and SARS: Implications for Vaccine Development T2 - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AN - 40106140; 4016982 JF - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AU - Subbarao, Kanta Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Fowl plague KW - Disease control KW - Vaccines KW - SARS coronavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40106140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.atitle=Host+Responses+to+Avian+Influenza+and+SARS%3A+Implications+for+Vaccine+Development&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunology of Non-Curing Forms of Leishmaniasis in Mice and Humans T2 - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AN - 40072274; 4016978 JF - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AU - Sacks, David L Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Mice KW - Immunology KW - Leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40072274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.atitle=Immunology+of+Non-Curing+Forms+of+Leishmaniasis+in+Mice+and+Humans&rft.au=Sacks%2C+David+L&rft.aulast=Sacks&rft.aufirst=David&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Innate Resistance to Intracellular Pathogens in Mouse Models T2 - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AN - 40012654; 4016962 JF - 2006 Keystone Symposia on Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2) AU - Sher, F Alan Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Pathogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40012654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.atitle=Mechanisms+of+Innate+Resistance+to+Intracellular+Pathogens+in+Mouse+Models&rft.au=Sher%2C+F+Alan&rft.aulast=Sher&rft.aufirst=F&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Determinants+of+Host+Resistance%2C+Susceptibility+or+Immunopathology+to+Pathogens%3A+Integrating+Knowledge+from+Experimental+Models+to+Human+Disease+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling T Cell Antigen Discrimination: The Key Role of Feedback Control Circuits T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39736306; 4040281 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Germain, Ronald N Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Circuits KW - Feedback KW - Discrimination KW - Lymphocytes T KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39736306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Modeling+T+Cell+Antigen+Discrimination%3A+The+Key+Role+of+Feedback+Control+Circuits&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Cytoskeleton in T Cell Signaling T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39734297; 4040269 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Schwartzberg, Pamela L Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Signal transduction KW - Lymphocytes T KW - Cytoskeleton KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39734297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=The+Cytoskeleton+in+T+Cell+Signaling&rft.au=Schwartzberg%2C+Pamela+L&rft.aulast=Schwartzberg&rft.aufirst=Pamela&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Signaling In Mast Cells T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39723888; 4040270 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Rivera, Juan Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Mast cells KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Integrating+Signaling+In+Mast+Cells&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Viewing the Initiation of B Cell Receptor Signaling in Living Cells by FRET T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39723824; 4040259 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Pierce, Susan K Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Fluorescence resonance energy transfer KW - Signal transduction KW - Lymphocytes B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Viewing+the+Initiation+of+B+Cell+Receptor+Signaling+in+Living+Cells+by+FRET&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signaling via the T cell Antigen Receptor T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39723791; 4040258 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Samelson, Lawrence E Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Signal transduction KW - Antigens KW - T-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Signaling+via+the+T+cell+Antigen+Receptor&rft.au=Samelson%2C+Lawrence+E&rft.aulast=Samelson&rft.aufirst=Lawrence&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoptotic Signaling and Disease T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39702455; 4040277 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - Lenardo, Michael J Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Apoptosis KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39702455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Apoptotic+Signaling+and+Disease&rft.au=Lenardo%2C+Michael+J&rft.aulast=Lenardo&rft.aufirst=Michael&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation T2 - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AN - 39692021; 4040280 JF - 2006 Keystone Symposia on Lymphocyte Activation and Signaling (A2) AU - O'Shea, John J Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 KW - Differentiation KW - Cytokines KW - Immunoregulation KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39692021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.atitle=Cytokine+Signaling+and+Lymphoid+Development%2C+Differentiation+and+Immunoregulation&rft.au=O%27Shea%2C+John+J&rft.aulast=O%27Shea&rft.aufirst=John&rft.date=2006-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=798 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations. AN - 67603585; 16391368 AB - Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled "Cancer Survivorship--Genetic Susceptibility and Second Primary Cancers." These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer. JF - Journal of the National Cancer Institute AU - Travis, Lois B AU - Rabkin, Charles S AU - Brown, Linda Morris AU - Allan, James M AU - Alter, Blanche P AU - Ambrosone, Christine B AU - Begg, Colin B AU - Caporaso, Neil AU - Chanock, Stephen AU - DeMichele, Angela AU - Figg, William Douglas AU - Gospodarowicz, Mary K AU - Hall, Eric J AU - Hisada, Michie AU - Inskip, Peter AU - Kleinerman, Ruth AU - Little, John B AU - Malkin, David AU - Ng, Andrea K AU - Offit, Kenneth AU - Pui, Ching-Hon AU - Robison, Leslie L AU - Rothman, Nathaniel AU - Shields, Peter G AU - Strong, Louise AU - Taniguchi, Toshiyasu AU - Tucker, Margaret A AU - Greene, Mark H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. travisl@mail.nih.gov Y1 - 2006/01/04/ PY - 2006 DA - 2006 Jan 04 SP - 15 EP - 25 VL - 98 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Carcinogens KW - Index Medicus KW - Multicenter Studies as Topic KW - Humans KW - Medical Informatics KW - Specimen Handling KW - Clinical Trials as Topic KW - Congresses as Topic KW - Antineoplastic Agents -- adverse effects KW - Radiotherapy -- adverse effects KW - Registries KW - Syndrome KW - Cohort Studies KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - United States -- epidemiology KW - Biotechnology KW - Survivors -- statistics & numerical data KW - Neoplasms -- drug therapy KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms -- radiotherapy KW - Neoplasms, Second Primary -- etiology KW - Neoplasms -- mortality KW - Neoplasms, Second Primary -- genetics KW - Neoplasms, Radiation-Induced -- chemically induced KW - Neoplasms, Radiation-Induced -- genetics KW - Neoplasms, Second Primary -- chemically induced KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67603585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cancer+survivorship--genetic+susceptibility+and+second+primary+cancers%3A+research+strategies+and+recommendations.&rft.au=Travis%2C+Lois+B%3BRabkin%2C+Charles+S%3BBrown%2C+Linda+Morris%3BAllan%2C+James+M%3BAlter%2C+Blanche+P%3BAmbrosone%2C+Christine+B%3BBegg%2C+Colin+B%3BCaporaso%2C+Neil%3BChanock%2C+Stephen%3BDeMichele%2C+Angela%3BFigg%2C+William+Douglas%3BGospodarowicz%2C+Mary+K%3BHall%2C+Eric+J%3BHisada%2C+Michie%3BInskip%2C+Peter%3BKleinerman%2C+Ruth%3BLittle%2C+John+B%3BMalkin%2C+David%3BNg%2C+Andrea+K%3BOffit%2C+Kenneth%3BPui%2C+Ching-Hon%3BRobison%2C+Leslie+L%3BRothman%2C+Nathaniel%3BShields%2C+Peter+G%3BStrong%2C+Louise%3BTaniguchi%2C+Toshiyasu%3BTucker%2C+Margaret+A%3BGreene%2C+Mark+H&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2006-01-04&rft.volume=98&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Gene-Specific Changes in Promoter Occupancy by Thyroid Hormone Receptor During Frog Metamorphosis: Implications for Developmental Gene Regulation T2 - 2006 Annual Meeting of the Society for Integrative and Comparative Biology AN - 39785537; 4054753 JF - 2006 Annual Meeting of the Society for Integrative and Comparative Biology AU - Buchholz, D R AU - Paul, B P AU - Shi, Y.-B. Y1 - 2006/01/04/ PY - 2006 DA - 2006 Jan 04 KW - Hormones KW - Metamorphosis KW - Promoters KW - Thyroid hormone receptors KW - Gene regulation KW - Life cycle KW - Biological development KW - Amphibiotic species KW - Anura KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39785537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+Society+for+Integrative+and+Comparative+Biology&rft.atitle=Gene-Specific+Changes+in+Promoter+Occupancy+by+Thyroid+Hormone+Receptor+During+Frog+Metamorphosis%3A+Implications+for+Developmental+Gene+Regulation&rft.au=Buchholz%2C+D+R%3BPaul%2C+B+P%3BShi%2C+Y.-B.&rft.aulast=Buchholz&rft.aufirst=D&rft.date=2006-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+Society+for+Integrative+and+Comparative+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.sicb.org/meetings/2006/schedule/sessionresults.php3?search=sessi onnumber%3D%27P2%27 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Parkinson's Disease alpha -Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death AN - 19834878; 6664467 AB - alpha -Synuclein ( alpha -Syn) is enriched in nerve terminals. Two mutations in the alpha -Syn gene (Ala53 arrow right Thr and Ala30 arrow right Pro) occur in autosomal dominant familial Parkinson's disease. Mice overexpressing the human A53T mutant alpha -Syn develop a severe movement disorder, paralysis, and synucleinopathy, but the mechanisms are not understood. We examined whether transgenic mice expressing human wild-type or familial Parkinson's disease-linked A53T or A30P mutant alpha -syn develop neuronal degeneration and cell death. Mutant mice were examined at early- to mid-stage disease and at near end-stage disease. Age-matched nontransgenic littermates were controls. In A53T mice, neurons in brainstem and spinal cord exhibited large axonal swellings, somal chromatolytic changes, and nuclear condensation. Spheroid eosinophilic Lewy body-like inclusions were present in the cytoplasm of cortical neurons and spinal motor neurons. These inclusions contained human alpha -syn and nitrated synuclein. Motor neurons were depleted ( similar to 75%) in A53T mice but were affected less in A30P mice. Axonal degeneration was present in many regions. Electron microscopy confirmed the cell and axonal degeneration and revealed cytoplasmic inclusions in dendrites and axons. Some inclusions were degenerating mitochondria and were positive for human alpha -syn. Mitochondrial complex IV and V proteins were at control levels, but complex IV activity was reduced significantly in spinal cord. Subsets of neurons in neocortex, brainstem, and spinal cord ventral horn were positive for terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, cleaved caspase-3, and p53. Mitochondria in neurons had terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling-positive matrices and p53 at the outer membrane. Thus, A53T mutant mice develop intraneuronal inclusions, mitochondrial DNA damage and degeneration, and apoptotic-like death of neocortical, brainstem, and motor neurons. JF - Journal of Neuroscience AU - Martin, Lee J AU - Pan, Yan AU - Price, Ann C AU - Sterling, Wanda AU - Copeland, Neal G AU - Jenkins, Nancy A AU - Price, Donald L AU - Lee, Michael K AD - Department of Pathology, Division of Neuropathology, and Departments of Neuroscience and Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, and Mouse Cancer Genetics Program, National Cancer Institute-Frederick Cancer Center Research and Development Center, Frederick, Maryland 21702 Y1 - 2006/01/04/ PY - 2006 DA - 2006 Jan 04 SP - 41 EP - 50 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 1 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Spinal cord KW - Parkinson's disease KW - Mitochondria KW - Cytochrome-c oxidase KW - Leukocytes (eosinophilic) KW - Ventral horn KW - Neurodegeneration KW - Cortex KW - Nerve endings KW - Cytoplasm KW - Degeneration KW - Synuclein KW - double prime V protein KW - Outer membranes KW - Brain stem KW - Transgenic mice KW - Lewy bodies KW - p53 protein KW - Paralysis KW - Neurodegenerative diseases KW - Motor neurons KW - Mitochondrial DNA KW - Cell death KW - Movement disorders KW - Caspase-3 KW - Inclusion bodies KW - Axons KW - Condensation KW - spheroids KW - Mutation KW - W 30925:Genetic Engineering KW - N3 11011:Motor systems and movement disorders KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19834878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Parkinson%27s+Disease+alpha+-Synuclein+Transgenic+Mice+Develop+Neuronal+Mitochondrial+Degeneration+and+Cell+Death&rft.au=Martin%2C+Lee+J%3BPan%2C+Yan%3BPrice%2C+Ann+C%3BSterling%2C+Wanda%3BCopeland%2C+Neal+G%3BJenkins%2C+Nancy+A%3BPrice%2C+Donald+L%3BLee%2C+Michael+K&rft.aulast=Martin&rft.aufirst=Lee&rft.date=2006-01-04&rft.volume=26&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Spinal cord; Parkinson's disease; Mitochondria; Cytochrome-c oxidase; Leukocytes (eosinophilic); Neurodegeneration; Ventral horn; Nerve endings; Cortex; Cytoplasm; Degeneration; Synuclein; double prime V protein; Brain stem; Outer membranes; Transgenic mice; p53 protein; Lewy bodies; Paralysis; Motor neurons; Neurodegenerative diseases; Cell death; Mitochondrial DNA; Movement disorders; Caspase-3; Inclusion bodies; Condensation; Axons; spheroids; Mutation ER - TY - JOUR T1 - Cognitive functioning in school-aged children with vertically acquired HIV infection being treated with highly active antiretroviral therapy (HAART). AN - 85396133; pmid-16995830 AB - In today's era of highly active antiretroviral therapy (HAART), few children with HIV-1 infection experience severe central nervous system (CNS) manifestations indicative of encephalopathy. However, little is known about the neurocognitive strengths and weaknesses of HIV-infected children treated with HAART. This cross-sectional study is the first to systematically investigate the relation between cognitive functioning and medical markers in HIV-infected children and adolescents treated with HAART with varying levels of computed tomography (CT) brain scan abnormalities. The Wechsler Intelligence Scale for Children-Third Edition was administered to 41 vertically infected children (mean age = 11.2 years) treated with HAART for at least 1 year. Other procedures at the time of testing included CT brain scans and collection of CD4 cell counts and plasma HIV1 RNA PCR. Although global cognitive functioning among participants was in the Average range, children with minimal to moderate CT brain scan abnormalities scored significantly lower than children with normal scans on composite measures of cognitive functioning and five specific subtests, especially tasks involving executive functions. Furthermore, children with worse immune status (CD4+ counts < or = 500) scored lower on subtests measuring processing speed. Viral load was unrelated to cognitive test scores. Thus, children with HIV being treated with HAART remain at risk for developing CNS disease. Findings emphasize the importance of conducting neuropsychological assessments in this population, particularly for children with cortical atrophy and absolute CD4+ cell counts < or = 500. JF - Developmental neuropsychology AU - Martin, Staci C AU - Wolters, Pamela L AU - Toledo-Tamula, Mary Anne AU - Zeichner, Steven L AU - Hazra, Rohan AU - Civitello, Lucy AD - HIV and AIDS Malignancy Branch, National Cancer Institute, 9030 Old Georgetown Road, Bethesda, MD 20814, USA. martins@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 633 EP - 657 VL - 30 IS - 2 SN - 8756-5641, 8756-5641 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - *Antiretroviral Therapy, Highly Active: methods KW - Child KW - *Cognition: drug effects KW - Cross-Sectional Studies KW - Female KW - HIV Infections: drug therapy KW - HIV Infections: physiopathology KW - HIV Infections: transmission KW - Humans KW - *Infectious Disease Transmission, Vertical KW - Male KW - Neuropsychological Tests: statistics & numerical data KW - Regression Analysis KW - Retrospective Studies KW - Tomography, X-Ray Computed: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+neuropsychology&rft.atitle=Cognitive+functioning+in+school-aged+children+with+vertically+acquired+HIV+infection+being+treated+with+highly+active+antiretroviral+therapy+%28HAART%29.&rft.au=Martin%2C+Staci+C%3BWolters%2C+Pamela+L%3BToledo-Tamula%2C+Mary+Anne%3BZeichner%2C+Steven+L%3BHazra%2C+Rohan%3BCivitello%2C+Lucy&rft.aulast=Martin&rft.aufirst=Staci&rft.date=2006-01-01&rft.volume=30&rft.issue=2&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Developmental+neuropsychology&rft.issn=87565641&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - ANALYSIS OF THE TRANSCRIPTIONAL REGULATION OF MELANOCYTIC GENES BY aaMSH USING THE CDNA aa MICROARRAY TECHNIQUE AN - 745936317; 13108353 AB - Studies of mammalian pigmentation have identified many genes involved in the development, migration, and function of melanocytes. Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two signaling molecules, a-Melanocyte Stimulating Hormone (aMSH) and Agouti Signal Protein (ASP). aMSH affects various aspects of melanocyte behavior, stimulating melanocyte dendricity, attachment to extracellular matrix proteins, but also up-regulating the expression of eumelanogenic genes. In response to ASP, melanocytes switch from producing eumelanin to pheomelanin concomitant with the down-regulation of melanogenic genes transcription. Since activation of signaling pathways leads to mRNA expression, microarray technology can provide a quantitative assessment of the consequences of this activation. Significant up/down regulation of all known melanogenic genes by aMSH/ASP in cultured melanocytes has been previously reported. We have now used the cDNA microarray technique to screen aMSH-treated melanocytes to identify genes that are transcriptionally enhanced by this factor. We report the melanocytic expression and aMSH up-regulation of 11 genes spanning 7 functional categories such as apoptosis, body weight control, intracellular transport, signal transduction, oncogenic transformation, transcription factors and genes coding for keratin associated proteins. JF - Cellular and Molecular Biology AU - Rouzaud, F AU - Hearing, V J AD - Laboratory of Cell Biology- National Institutes of Health, National Cancer Institute Bethesda, MD, 20892, USA, hearingv@nih.gov Y1 - 2006 PY - 2006 DA - 2006 VL - 52 IS - 2 SN - 0145-5680, 0145-5680 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Pigmentation KW - Apoptosis KW - Transcription KW - Melanocytes KW - Hormones KW - DNA microarrays KW - Gene expression KW - pheomelanin KW - Keratin KW - Body weight KW - Transcription factors KW - Gene regulation KW - Extracellular matrix KW - Signal transduction KW - W 30925:Genetic Engineering KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745936317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Biology&rft.atitle=ANALYSIS+OF+THE+TRANSCRIPTIONAL+REGULATION+OF+MELANOCYTIC+GENES+BY+aaMSH+USING+THE+CDNA+aa+MICROARRAY+TECHNIQUE&rft.au=Rouzaud%2C+F%3BHearing%2C+V+J&rft.aulast=Rouzaud&rft.aufirst=F&rft.date=2006-01-01&rft.volume=52&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Biology&rft.issn=01455680&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Transformation; Pigmentation; Apoptosis; Transcription; Melanocytes; DNA microarrays; Hormones; pheomelanin; Gene expression; Keratin; Body weight; Extracellular matrix; Gene regulation; Transcription factors; Signal transduction ER - TY - JOUR T1 - Cannabis withdrawal among non-treatment-seeking adult cannabis users. AN - 70732275; 16449088 AB - This study investigates the clinical significance of a cannabis withdrawal syndrome in 104 adult, non-treatment-seeking, primarily cannabis users who reported at least one serious attempt to stop using cannabis. Retrospective self-report data were obtained on eighteen potential cannabis withdrawal symptoms derived from the literature, including co-occurrence, time course, and any actions taken to relieve the symptom. Study findings provide evidence for the clinical significance of a cannabis withdrawal syndrome, based on the high prevalence and co-occurrence of multiple symptoms that follow a consistent time course and that prompt action by the subjects to obtain relief, including serving as negative reinforcement for cannabis use. JF - The American journal on addictions AU - Copersino, Marc L AU - Boyd, Susan J AU - Tashkin, Donald P AU - Huestis, Marilyn A AU - Heishman, Stephen J AU - Dermand, John C AU - Simmons, Michael S AU - Gorelick, David A AD - Clinical Pharmacology & Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health & Human Services, Baltimore, Maryland 21224-6823, USA. PY - 2006 SP - 8 EP - 14 VL - 15 IS - 1 SN - 1055-0496, 1055-0496 KW - Cannabinoids KW - 0 KW - Tranquilizing Agents KW - Index Medicus KW - Patient Acceptance of Health Care KW - Humans KW - Adult KW - Middle Aged KW - Longitudinal Studies KW - Alcohol Drinking -- epidemiology KW - Smoking -- epidemiology KW - Recurrence KW - Male KW - Female KW - Comorbidity KW - Tranquilizing Agents -- administration & dosage KW - Substance Withdrawal Syndrome -- etiology KW - Substance Withdrawal Syndrome -- diagnosis KW - Substance Withdrawal Syndrome -- epidemiology KW - Marijuana Abuse -- rehabilitation KW - Cannabinoids -- adverse effects KW - Substance Withdrawal Syndrome -- psychology KW - Self Care -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70732275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Cannabis+withdrawal+among+non-treatment-seeking+adult+cannabis+users.&rft.au=Copersino%2C+Marc+L%3BBoyd%2C+Susan+J%3BTashkin%2C+Donald+P%3BHuestis%2C+Marilyn+A%3BHeishman%2C+Stephen+J%3BDermand%2C+John+C%3BSimmons%2C+Michael+S%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2006-01-01&rft.volume=15&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. AN - 70727069; 16449207 AB - Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging disorder Werner syndrome (WS). Evidence suggests that the Werner syndrome protein (WRN) contributes to the maintenance of genome integrity through its involvement in DNA repair. In particular, biochemical evidence indicates a role for WRN in base excision repair (BER). We have previously reported that WRN helicase activity stimulates DNA polymerase beta (pol beta) strand displacement synthesis in vitro. In this report we demonstrate that WRN exonuclease activity can act cooperatively with pol beta, a polymerase lacking 3'-5' proofreading activity. Furthermore, using small interference RNA technology, we demonstrate that WRN knockdown cells are hypersensitive to the alkylating agent methyl methanesulfonate, which creates DNA damage that is primarily repaired by the BER pathway. In addition, repair assays using whole cell extracts from WRN knockdown cells indicate a defect in long patch (LP) BER. These findings demonstrate that WRN plays a direct role in the repair of methylation-induced DNA damage, and suggest a role for both WRN helicase and exonuclease activities together with pol beta during LP BER. JF - Nucleic acids research AU - Harrigan, Jeanine A AU - Wilson, David M AU - Prasad, Rajendra AU - Opresko, Patricia L AU - Beck, Gad AU - May, Alfred AU - Wilson, Samuel H AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 745 EP - 754 VL - 34 IS - 2 KW - Alkylating Agents KW - 0 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Exodeoxyribonucleases KW - EC 3.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Index Medicus KW - Methyl Methanesulfonate -- toxicity KW - DNA Damage KW - Humans KW - Base Pair Mismatch KW - Alkylating Agents -- toxicity KW - RNA Interference KW - Cell Line KW - DNA Repair KW - DNA Helicases -- physiology KW - DNA Helicases -- antagonists & inhibitors KW - Exodeoxyribonucleases -- physiology KW - Exodeoxyribonucleases -- antagonists & inhibitors KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70727069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=The+Werner+syndrome+protein+operates+in+base+excision+repair+and+cooperates+with+DNA+polymerase+beta.&rft.au=Harrigan%2C+Jeanine+A%3BWilson%2C+David+M%3BPrasad%2C+Rajendra%3BOpresko%2C+Patricia+L%3BBeck%2C+Gad%3BMay%2C+Alfred%3BWilson%2C+Samuel+H%3BBohr%2C+Vilhelm+A&rft.aulast=Harrigan&rft.aufirst=Jeanine&rft.date=2006-01-01&rft.volume=34&rft.issue=2&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-15 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: DNA Repair (Amst). 2002 Apr 29;1(4):317-33 [12509250] Carcinogenesis. 2003 May;24(5):791-802 [12771022] J Biol Chem. 2003 Jun 20;278(25):22686-95 [12665521] Mutat Res. 2003 Nov 27;532(1-2):215-26 [14643438] Biochimie. 2003 Nov;85(11):1185-93 [14726023] Nat Rev Mol Cell Biol. 2004 Feb;5(2):148-57 [15040447] J Biol Chem. 2004 May 14;279(20):21169-76 [15026416] DNA Repair (Amst). 2004 Jun 3;3(6):629-38 [15135730] Biochem Biophys Res Commun. 2004 Oct 22;323(3):831-7 [15381075] Biochimie. 1982 Aug-Sep;64(8-9):637-41 [6814512] Anal Biochem. 1984 Aug 15;141(1):70-3 [6496937] Mutat Res. 1985 Jun-Jul;150(1-2):77-84 [4000169] Ann N Y Acad Sci. 1992 Nov 21;663:85-96 [1482105] Proc Natl Acad Sci U S A. 1997 May 27;94(11):5831-6 [9159160] J Biol Chem. 1998 Jan 9;273(2):898-902 [9422747] J Biol Chem. 1998 Dec 18;273(51):34145-50 [9852074] J Biol Chem. 1999 Feb 5;274(6):3642-50 [9920913] Hum Genet. 1999 Jan;104(1):10-4 [10071186] EMBO J. 1999 Jul 1;18(13):3868-75 [10393201] Nature. 2002 Feb 7;415(6872):655-9 [11832948] Oncogene. 2002 Jan 31;21(6):954-63 [11840341] J Mol Biol. 2002 Feb 22;316(3):853-66 [11866537] Nat Rev Mol Cell Biol. 2002 May;3(5):364-76 [11988770] J Mol Biol. 2002 Aug 16;321(3):459-78 [12162959] Mol Cell Biol. 2002 Oct;22(20):6971-8 [12242278] J Biol Chem. 2002 Nov 1;277(44):41379-89 [12196536] J Biol Chem. 1999 Jul 9;274(28):19655-60 [10391904] Nucleic Acids Res. 1999 Sep 1;27(17):3557-66 [10446247] Nucleic Acids Res. 1999 Oct 15;27(20):4028-33 [10497267] J Biol Chem. 2004 Dec 17;279(51):53465-74 [15385537] Nucleic Acids Res. 2005;33(1):280-8 [15647510] J Biol Chem. 2005 Feb 4;280(5):3665-74 [15561706] Free Radic Biol Med. 2005 May 1;38(9):1121-38 [15808410] Mol Cell Biol. 2005 Dec;25(23):10492-506 [16287861] J Biol Chem. 1999 Dec 10;274(50):35866-72 [10585471] J Biol Chem. 2000 Jan 21;275(3):2211-8 [10636928] Hum Mol Genet. 2000 Feb 12;9(3):403-11 [10655550] J Mol Biol. 2000 May 5;298(3):447-59 [10772862] Nucleic Acids Res. 2000 Jun 15;28(12):2396-405 [10871373] Genes Dev. 2001 Apr 15;15(8):933-8 [11316787] FASEB J. 2001 May;15(7):1224-6 [11344095] J Biol Chem. 2001 Feb 2;276(5):3024-30 [11110789] J Biol Chem. 2001 Jul 6;276(27):25541-8 [11340072] Nucleic Acids Res. 2001 Jul 1;29(13):2843-9 [11433031] J Biol Chem. 2001 Aug 31;276(35):32411-4 [11440997] N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - The alcohol clamp: applications, challenges, and new directions--an RSA 2004 symposium summary. AN - 70702632; 16433744 AB - This article summarizes the proceedings of a symposium organized and cochaired by Vijay Ramchandani and Sean O'Connor and presented at the 2004 Research Society on Alcoholism meeting in Vancouver, BC, Canada. The objectives of this symposium were: (1) to provide a rationale for the development and use of the alcohol clamp and the requirements for its use in alcohol challenge studies; (2) to highlight recent studies conducted using the alcohol clamp to identify sources of variation in the pharmacokinetics and pharmacodynamics of alcohol, as well as to address important research questions related to the relationship between the response to alcohol and the risk for alcoholism; and (3) to provide a perspective on progress, address limitations of the clamp, and identify new directions for alcohol challenge research. The symposium began with an introduction and overview of the alcohol clamp, by Vijay Ramchandani. This was followed by 4 presentations that highlighted recent studies conducted using the clamp including: (1) determination of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in a male Jewish population, by Yehuda Neumark; (2) examination of family history of alcoholism, recent drinking history, and levels and rates of administration as determinants of the response to alcohol and risk for alcoholism, by Sean O'Connor; (3) evaluation of the time course of ethanol intoxication on neuroendocrine function in humans, by Ulrich Zimmermann; and (4) a study of the effects of steady-state blood alcohol levels on auditory event-related potentials in rats, by Sandra Morzorati. Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future directions for research using the alcohol clamp. JF - Alcoholism, clinical and experimental research AU - Ramchandani, Vijay A AU - O'connor, Sean AU - Neumark, Yehuda AU - Zimmermann, Ulrich S AU - Morzorati, Sandra L AU - de Wit, Harriet Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 155 EP - 164 VL - 30 IS - 1 KW - Ethanol KW - 3K9958V90M KW - Alcohol Dehydrogenase KW - EC 1.1.1.1 KW - Index Medicus KW - Rats KW - Hypothalamo-Hypophyseal System -- drug effects KW - Animals KW - Humans KW - Evoked Potentials, Auditory -- drug effects KW - Alcohol Dehydrogenase -- genetics KW - Rats, Wistar KW - Clinical Trials as Topic KW - Alcoholic Intoxication -- blood KW - Pituitary-Adrenal System -- drug effects KW - Male KW - Ethanol -- pharmacokinetics KW - Alcoholism -- diagnosis KW - Blood Chemical Analysis -- methods KW - Alcoholism -- genetics KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70702632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=The+alcohol+clamp%3A+applications%2C+challenges%2C+and+new+directions--an+RSA+2004+symposium+summary.&rft.au=Ramchandani%2C+Vijay+A%3BO%27connor%2C+Sean%3BNeumark%2C+Yehuda%3BZimmermann%2C+Ulrich+S%3BMorzorati%2C+Sandra+L%3Bde+Wit%2C+Harriet&rft.aulast=Ramchandani&rft.aufirst=Vijay&rft.date=2006-01-01&rft.volume=30&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-17 N1 - Date created - 2006-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis. AN - 70698076; 16417217 AB - In this study, we analyze the expression and potential function of the Krüppel-like zinc-finger protein Gli-similar protein 1 (Glis1) in normal and inflammatory skin and in the differentiation of epidermal keratinocytes. Glis1 mRNA is not expressed in normal human epidermis, but is significantly induced in psoriatic epidermis and in mouse skin upon treatment with the tumor promoter phorbol-12-myristate-13-acetate (PMA). The expression of Glis1 is restricted to the suprabasal layers. These observations suggest that Glis1 expression is associated with hyperplastic, inflammatory epidermis. Consistent with these findings, Glis1 mRNA is not expressed in undifferentiated or differentiated normal human epidermal keratinocytes (NHEK) in culture, but is dramatically induced after the addition of PMA or interferon gamma. A similar induction of Glis1 mRNA by PMA treatment was observed in the immortalized epidermal keratinocyte cell line NHEK-HPV, whereas PMA did not induce Glis1 in HaCaT cells or in several squamous cell carcinoma cell lines. To obtain insight into its function, Glis1 and a C-terminal deletion mutant Glis1DeltaC were expressed in NHEK-HPV cells and changes in epidermal differentiation and gene expression examined. Microarray analysis revealed that Glis1DeltaC promoted PMA-induced epidermal differentiation, as indicated by increased expression of many differentiation-specific genes. This, in association with its induction in psoriasis, suggests that transcriptional factor Glis1 is involved in the regulation of aberrant differentiation observed in psoriatic epidermis. JF - The Journal of investigative dermatology AU - Nakanishi, Gen AU - Kim, Yong-Sik AU - Nakajima, Takeshi AU - Jetten, Anton M AD - Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 49 EP - 60 VL - 126 IS - 1 SN - 0022-202X, 0022-202X KW - DNA-Binding Proteins KW - 0 KW - GLIS1 protein, human KW - RNA, Messenger KW - Transcription Factors KW - phorbolol myristate acetate KW - 56937-68-9 KW - Interferon-gamma KW - 82115-62-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Tetradecanoylphorbol Acetate -- analogs & derivatives KW - Humans KW - Cell Nucleus -- chemistry KW - RNA, Messenger -- analysis KW - Cell Differentiation -- genetics KW - Interferon-gamma -- pharmacology KW - Mice KW - Cytoplasm -- chemistry KW - Gene Expression Profiling KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Keratinocytes -- cytology KW - Keratinocytes -- metabolism KW - Keratinocytes -- pathology KW - Mutation KW - Sequence Deletion KW - DNA-Binding Proteins -- analysis KW - Transcription Factors -- metabolism KW - Psoriasis -- genetics KW - Epidermis -- cytology KW - Epidermis -- metabolism KW - DNA-Binding Proteins -- genetics KW - Transcription Factors -- analysis KW - Gene Expression Regulation KW - Epidermis -- pathology KW - Transcription Factors -- genetics KW - Psoriasis -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70698076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Regulatory+role+for+Kr%C3%BCppel-like+zinc-finger+protein+Gli-similar+1+%28Glis1%29+in+PMA-treated+and+psoriatic+epidermis.&rft.au=Nakanishi%2C+Gen%3BKim%2C+Yong-Sik%3BNakajima%2C+Takeshi%3BJetten%2C+Anton+M&rft.aulast=Nakanishi&rft.aufirst=Gen&rft.date=2006-01-01&rft.volume=126&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-23 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Cell Biol. 1999 Sep;1(5):312-9 [10559945] Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L144-52 [15778248] Nat Genet. 2000 Mar;24(3):216-7 [10700170] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3438-43 [10725363] Am J Health Syst Pharm. 2000 Apr 1;57(7):645-59; quiz 660-1 [10768819] J Invest Dermatol. 2000 May;114(5):901-8 [10771469] Am J Hum Genet. 2000 Nov;67(5):1047-54 [11001584] Cell Mol Life Sci. 2000 Nov;57(12):1720-31 [11130178] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3156-61 [11248048] Development. 2001 Apr;128(8):1335-46 [11262234] Curr Opin Genet Dev. 2001 Aug;11(4):410-7 [11448627] Cancer Lett. 2001 Nov 8;173(1):1-7 [11578802] J Invest Dermatol. 2001 Nov;117(5):1274-81 [11710944] Gene. 2001 Dec 12;280(1-2):49-57 [11738817] J Biol Chem. 2002 Mar 22;277(12):10139-49 [11741991] Nat Rev Cancer. 2002 May;2(5):361-72 [12044012] Br J Dermatol. 2002 Jul;147(1):87-94 [12100189] Mol Pathol. 2002 Aug;55(4):235-41 [12147714] J Biol Chem. 2002 Aug 23;277(34):30901-13 [12042312] Annu Rev Genomics Hum Genet. 2002;3:47-65 [12142354] Cancer Res. 2002 Sep 15;62(18):5308-16 [12235001] Mech Dev. 2002 Nov;119(1):21-34 [12385751] J Investig Dermatol Symp Proc. 2002 Dec;7(1):41-5 [12518791] J Biol Chem. 2003 Jan 17;278(3):1758-68 [12419822] Genes Dev. 2003 Jan 15;17(2):282-94 [12533516] J Biol Chem. 2003 Feb 14;278(7):5116-22 [12426310] Dev Biol. 2003 Mar 15;255(2):238-48 [12648487] Nucleic Acids Res. 2003 Oct 1;31(19):5513-25 [14500813] BMC Dermatol. 2002 Apr 29;2:7 [11978185] Dev Biol. 2003 Nov 15;263(2):203-15 [14597196] J Invest Dermatol. 2004 Jun;122(6):1503-9 [15175043] Am J Physiol Cell Physiol. 2004 Jul;287(1):C171-81 [15189821] J Invest Dermatol. 2004 Jul;123(1):23-33 [15191538] Nucleic Acids Res. 2004;32(14):4194-204 [15302918] Dermatol Ther. 2004;17(5):341-9 [15379769] J Invest Dermatol. 1987 Jan;88(1):60-5 [2878959] Skin Pharmacol. 1991;4(4):262-71 [1789987] J Invest Dermatol. 1992 Mar;98(3):364-8 [1347556] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11026-30 [1438308] J Biol Chem. 1994 Jan 21;269(3):2016-22 [7904998] Environ Health Perspect. 1993 Dec;101 Suppl 5:95-101 [8013432] J Invest Dermatol. 1996 Apr;106(4):647-54 [8617999] Dev Biol. 1996 Feb 1;173(2):490-8 [8606007] J Dermatol Sci. 1996 Nov;13(2):98-106 [8953408] J Invest Dermatol. 1997 Feb;108(2):200-4 [9008234] Skin Pharmacol. 1996;9(6):343-54 [9055355] J Natl Cancer Inst. 1997 Aug 6;89(15):1103-9 [9262247] Nature. 1997 Oct 23;389(6653):876-81 [9349822] J Dermatol. 1997 Nov;24(11):711-25 [9433028] Br J Dermatol. 1998 Jul;139(1):16-22 [9764143] Curr Biol. 1998 Sep 24;8(19):1058-68 [9768360] Dev Biol. 1999 Jan 1;205(1):1-9 [9882493] Br J Dermatol. 1998 Nov;139(5):911-5 [9892966] Development. 1999 Jun;126(14):3205-16 [10375510] Oncogene. 1999 Dec 20;18(55):7852-9 [10630638] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens. AN - 70697635; 16420432 AB - Quantitative and conventional microdialysis were used to investigate the effects of constitutive deletion of the prodynorphin gene on basal dopamine (DA) dynamics in the nucleus accumbens (NAc) and the responsiveness of DA neurons to an acute cocaine challenge. Saline- and cocaine-evoked locomotor activity were also assessed. Quantitative microdialysis revealed that basal extracellular DA levels were decreased, while the DA extraction fraction, an indirect measure of DA uptake, was unchanged in dynorphin (DYN) knockout (KO) mice. The ability of cocaine to increase NAc DA levels was reduced in KO. Similarly, cocaine-evoked locomotor activity was decreased in KO. The selective kappa opioid receptor agonist U-69593 decreased NAc dialysate DA levels in wildtype mice and this effect was enhanced in KO. Administration of the selective kappa opioid receptor (KOPr) antagonist nor-binaltorphimine to KO mice attenuated the decrease in cocaine-induced DA levels. However, it was ineffective in altering the decreased locomotor response to cocaine. These studies demonstrate that constitutive deletion of prodynorphin is associated with a reduction of extracellular NAc DA levels and a decreased responsiveness to acute cocaine. Data regarding the effects of U-69593 and nor-binaltorphimine in KO suggest that the kappa opioid receptor is up-regulated as a consequence of prodynorphin gene deletion and that this adaptation underlies the decrease in basal DA dynamics and cocaine-evoked DA levels observed in DYN KO mice. These findings suggest that the phenotype of DYN KO mice is not solely due to loss of endogenous opioid peptide but also reflects developmental compensations that occur at the level of the opioid receptor. JF - The European journal of neuroscience AU - Chefer, V I AU - Shippenberg, T S AD - Integrative Neuroscience Section, Behavioral Neuroscience Branch, DHHS/NIH/NIDA/IRP/BNRB/INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. vchefer@intra.nida.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 229 EP - 238 VL - 23 IS - 1 SN - 0953-816X, 0953-816X KW - Analgesics KW - 0 KW - Benzeneacetamides KW - Dopamine Uptake Inhibitors KW - Narcotic Antagonists KW - Pyrrolidines KW - norbinaltorphimine KW - 36OOQ86QM1 KW - Naltrexone KW - 5S6W795CQM KW - Dynorphins KW - 74913-18-1 KW - Cocaine KW - I5Y540LHVR KW - U 69593 KW - J5S4K6TKTG KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Benzeneacetamides -- pharmacology KW - Drug Interactions KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Naltrexone -- analogs & derivatives KW - Analgesics -- pharmacology KW - Mice KW - Microdialysis -- methods KW - Behavior, Animal KW - Mice, Knockout KW - Electrochemistry -- methods KW - Naltrexone -- pharmacology KW - Chromatography, High Pressure Liquid -- methods KW - Mice, Inbred C57BL KW - Pyrrolidines -- pharmacology KW - Motor Activity -- drug effects KW - Narcotic Antagonists -- pharmacology KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- physiology KW - Dopamine -- metabolism KW - Cocaine -- pharmacology KW - Dynorphins -- deficiency KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70697635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Paradoxical+effects+of+prodynorphin+gene+deletion+on+basal+and+cocaine-evoked+dopaminergic+neurotransmission+in+the+nucleus+accumbens.&rft.au=Chefer%2C+V+I%3BShippenberg%2C+T+S&rft.aulast=Chefer&rft.aufirst=V&rft.date=2006-01-01&rft.volume=23&rft.issue=1&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-06 N1 - Date created - 2006-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular approaches in pediatric oncology. AN - 70669835; 16409138 AB - The use of molecular approaches has become part of the standard of care in the management of pediatric cancer patients. Molecular approaches are now included in the initial diagnosis, definition of prognostically distinct patient subgroups, selection of patients for specific therapies, prediction of risk for toxicities to therapy, and monitoring of patients receiving both conventional and novel targeted therapies. This clinical application of molecular medicine has been based on a growing molecular understanding of cancer biology. Studies of pediatric cancers have contributed to this understanding in many ways. We present a model for understanding cancer biology, using specific examples taken from pediatric oncology, and then discuss the application of molecular techniques to the clinical management of pediatric cancer patients. JF - Annual review of medicine AU - Khanna, Chand AU - Helman, Lee J AD - Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA. khannac@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 83 EP - 97 VL - 57 SN - 0066-4219, 0066-4219 KW - Index Medicus KW - Humans KW - Child KW - Neoplasms -- diagnosis KW - Genetic Techniques KW - Neoplasms -- therapy KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70669835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+medicine&rft.atitle=Molecular+approaches+in+pediatric+oncology.&rft.au=Khanna%2C+Chand%3BHelman%2C+Lee+J&rft.aulast=Khanna&rft.aufirst=Chand&rft.date=2006-01-01&rft.volume=57&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+medicine&rft.issn=00664219&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-04 N1 - Date created - 2006-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk of lung cancer and exposure to industrial acids, solvents, and metals in leningrad province, Russia. AN - 70665167; 16404209 AB - We sought to investigate the association of occupational exposure to industrial acids, solvents, and metals with lung cancer in Leningrad Province, Russia, where an excess of occupationally related lung cancer was reported recently. We identified 540 pathologically diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 Leningrad Province hospitals. Lifetime job-specific exposure measurements were available for 12 industrial acids, 15 solvents, and 17 metals. Exposures were frequent in the study group and mostly occurred after World War II. However, lung cancer risks for industrial acids (odds ratio [OR] = 1.2; 95% confidence interval [CI] = 0.8-1.7), solvents (OR = 0.8; 95% CI = 0.6-1.2), and metals (OR = 0.8; 95% CI = 0.5-1.0) were not increased. Also, no significant excess risk was found for any of the specific agents investigated. The excess of occupationally related lung cancer in the Province is not explained by exposure to the agents investigated. JF - Journal of occupational and environmental medicine AU - Baccarelli, Andrea AU - Tretiakova, Maria AU - Gorbanev, Sergey AU - Lomtev, Alexei AU - Klimkina, Irina AU - Tchibissov, Vladimir AU - Averkina, Olga AU - Dosemeci, Mustafa AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. andrea.baccarelli@unimi.it Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 48 EP - 55 VL - 48 IS - 1 SN - 1076-2752, 1076-2752 KW - Acids KW - 0 KW - Metals KW - Solvents KW - Index Medicus KW - Humans KW - Aged KW - Smoking -- epidemiology KW - Russia -- epidemiology KW - Risk KW - Aged, 80 and over KW - Logistic Models KW - Maximum Allowable Concentration KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Female KW - Male KW - Industry KW - Metals -- adverse effects KW - Lung Neoplasms -- epidemiology KW - Acids -- adverse effects KW - Solvents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Lung Neoplasms -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70665167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Risk+of+lung+cancer+and+exposure+to+industrial+acids%2C+solvents%2C+and+metals+in+leningrad+province%2C+Russia.&rft.au=Baccarelli%2C+Andrea%3BTretiakova%2C+Maria%3BGorbanev%2C+Sergey%3BLomtev%2C+Alexei%3BKlimkina%2C+Irina%3BTchibissov%2C+Vladimir%3BAverkina%2C+Olga%3BDosemeci%2C+Mustafa&rft.aulast=Baccarelli&rft.aufirst=Andrea&rft.date=2006-01-01&rft.volume=48&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-31 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates. AN - 70658289; 16409123 AB - In this study we examine the safety, feasibility, and biodistribution of a tumor-selective mutant vaccinia (vvDD) and wild-type WR (vF13) vaccinia after delivery via intradermal or intravenous infection or isolated limb perfusion (ILP) in rhesus macaques. By intradermal inoculation, 10(6) PFU of vvDD caused a minimal skin reaction whereas vF13 caused marked erythema and necrosis with a peak indurated area of 108 cm2. By intravenous delivery, vvDD caused no clinical symptoms of viremia and no viral recovery from tissues, serum, saliva, urine, or feces. In contrast, vF13 caused symptoms of lethargy, anorexia, fever, and signs of viremia. Delivery of vF13 via ILP resulted in numerous cutaneous pox lesions localized solely to the perfused limb with high viral recovery in the perfused skin and muscle. ILP with vvDD resulted in no visible pox lesions and no clinical signs or symptoms of viremia. No long-term toxicity was identified after ILP with 10(9) PFU of vvDD, and no virus was recovered from any tissue, serum, saliva, urine, or fecal sample. These results suggest that vvDD appears to be safe in primates, and thus vvDD should be further investigated for clinical trial in human cancer patients. JF - Human gene therapy AU - Naik, Arpana M AU - Chalikonda, Sricharan AU - McCart, J Andrea AU - Xu, Hui AU - Guo, Z Sheng AU - Langham, Gregory AU - Gardner, Donald AU - Mocellin, Simone AU - Lokshin, Anna E AU - Moss, Bernard AU - Alexander, H Richard AU - Bartlett, David L AD - Center for Cancer Research, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 31 EP - 45 VL - 17 IS - 1 SN - 1043-0342, 1043-0342 KW - Antibodies, Viral KW - 0 KW - Interleukin-6 KW - Peptides KW - vaccinia growth factor KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Humans KW - Perfusion -- methods KW - Liver -- chemistry KW - Antibodies, Viral -- blood KW - Injections, Intradermal KW - Interleukin-6 -- blood KW - Extremities -- virology KW - Mutation -- genetics KW - Macaca mulatta KW - Peptides -- genetics KW - Female KW - Male KW - Thymidine Kinase -- genetics KW - Infusions, Intravenous -- methods KW - Genetic Vectors -- standards KW - Vaccinia virus -- genetics KW - Genetic Vectors -- administration & dosage KW - Vaccinia virus -- immunology KW - Vaccinia virus -- physiology KW - Genetic Therapy -- standards KW - Genetic Therapy -- methods KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70658289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+gene+therapy&rft.atitle=Intravenous+and+isolated+limb+perfusion+delivery+of+wild+type+and+a+tumor-selective+replicating+mutant+vaccinia+virus+in+nonhuman+primates.&rft.au=Naik%2C+Arpana+M%3BChalikonda%2C+Sricharan%3BMcCart%2C+J+Andrea%3BXu%2C+Hui%3BGuo%2C+Z+Sheng%3BLangham%2C+Gregory%3BGardner%2C+Donald%3BMocellin%2C+Simone%3BLokshin%2C+Anna+E%3BMoss%2C+Bernard%3BAlexander%2C+H+Richard%3BBartlett%2C+David+L&rft.aulast=Naik&rft.aufirst=Arpana&rft.date=2006-01-01&rft.volume=17&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Human+gene+therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-17 N1 - Date created - 2006-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. AN - 70205105; 15864587 AB - Apoptosis has an essential role in embryogenesis, adult tissue homeostasis and cellular responses to stressful stimuli. Therefore, increased apoptosis is involved in the pathogenesis of various ischaemic, degenerative and immune disorders. Conversely, genetic aberration that results in a reduction or abolition of apoptosis can promote tumorigenesis and underlie the resistance of cancer cells to various genotoxic anticancer agents. Therefore, a detailed knowledge of the control of apoptotic pathways could aid in the rational design of effective therapeutics for a variety of human diseases including cancer. One major way to promote apoptosis involves signaling through members of the tumor necrosis factor (TNF) superfamily. On binding to their appropriate receptors, some TNF family members can promote caspase activation and apoptosis. Early studies on TNF indicated that a limited number of tumor cell lines could be induced to undergo apoptosis on exposure to TNF. Another member of the TNF family Fas ligand (FasL) is also known to induce apoptosis in a variety of tumor cells. Although TNF and FasL can efficiently induce apoptosis in a limited number of tumor cells, administration of either of these agents is associated with extreme toxicity. This toxicity has precluded further development of either TNF or FasL for cancer therapy. However, within the last 8 years another member of the TNF family, TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) has been characterized, which induces apoptosis of a wider range of cancer cells than either TNF or FasL. Surprisingly, most normal non-transformed cells are quite resistant to the apoptotic effects of Apo2L/TRAIL. This selective toxicity for cancer cells is the basis for the current enthusiasm for Apo2L/TRAIL as a potential novel anticancer therapy. In this symposium report, we provide a brief overview of Apo2L/TRAIL, its receptors and their signaling pathways. We discuss findings on the antitumor effects of Apo2L/TRAIL alone or in combination with radiotherapy or chemotherapy. In addition, we present recent information from our groups concerning the possible therapeutic benefits of combining Apo2L/TRAIL with the proteasome inhibitor bortezomib. JF - Cancer immunology, immunotherapy : CII AU - Sayers, Thomas J AU - Murphy, William J AD - Intramural Research Program, SAIC-Frederick, Laboratory of Experimental Immunology, National Cancer Institute-Center for Cancer Research, Frederick, MD 21702-1201, USA. sayers@mail.ncifcrf.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 76 EP - 84 VL - 55 IS - 1 SN - 0340-7004, 0340-7004 KW - Apoptosis Regulatory Proteins KW - 0 KW - Boronic Acids KW - Membrane Glycoproteins KW - Protease Inhibitors KW - Pyrazines KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - Tumor Necrosis Factor-alpha KW - Bortezomib KW - 69G8BD63PP KW - Index Medicus KW - Humans KW - Neoplasms -- therapy KW - Signal Transduction KW - Neoplasms -- immunology KW - Protease Inhibitors -- therapeutic use KW - Boronic Acids -- pharmacology KW - Protease Inhibitors -- pharmacology KW - Pyrazines -- therapeutic use KW - Pyrazines -- pharmacology KW - Membrane Glycoproteins -- therapeutic use KW - Apoptosis -- drug effects KW - Apoptosis Regulatory Proteins -- therapeutic use KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- therapeutic use KW - Boronic Acids -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70205105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Combining+proteasome+inhibition+with+TNF-related+apoptosis-inducing+ligand+%28Apo2L%2FTRAIL%29+for+cancer+therapy.&rft.au=Sayers%2C+Thomas+J%3BMurphy%2C+William+J&rft.aulast=Sayers&rft.aufirst=Thomas&rft.date=2006-01-01&rft.volume=55&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-28 N1 - Date created - 2005-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug. AN - 70199506; 16315224 AB - PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent prodrug for localizing NO's therapeutic effects at the site of application, but a difficult one to formulate and certify as pure. Despite its extraordinary thermal and hydrolytic instability, however, PROLI/NO could be formulated as an injectable drug by dissolving it in cold 0.1 M sodium hydroxide containing 5% D-mannitol, then quickly ultrafiltering and lyophilizing it in evacuated septum vials. No evidence for decomposition was seen in the contents of these evacuated vials when stored at -20 degrees C over a 140-day observation period, as judged by quantifying NO release in simulated infusate solutions (10 mM carbonate/bicarbonate, pH 10.5). The only hydrolysis products detected were NO, nitrite ion, proline, and N-nitrosoproline, all products of normal human physiological processes. JF - Journal of pharmaceutical sciences AU - Waterhouse, David J AU - Saavedra, Joseph E AU - Davies, Keith M AU - Citro, Michael L AU - Xu, Xia AU - Powell, Douglas A AU - Grimes, George J AU - Potti, Gopal K AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Maryland 21702, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 108 EP - 115 VL - 95 IS - 1 SN - 0022-3549, 0022-3549 KW - Nitric Oxide Donors KW - 0 KW - Nitrogen Oxides KW - Prodrugs KW - proline-nitric oxide KW - Nitric Oxide KW - 31C4KY9ESH KW - Proline KW - 9DLQ4CIU6V KW - Index Medicus KW - Nitric Oxide -- analysis KW - Injections, Intravenous KW - Drug Compounding KW - Hydrolysis KW - Drug Storage KW - Proline -- chemistry KW - Prodrugs -- chemistry KW - Prodrugs -- analysis KW - Nitrogen Oxides -- chemistry KW - Proline -- analysis KW - Nitric Oxide Donors -- analysis KW - Nitrogen Oxides -- analysis KW - Proline -- analogs & derivatives KW - Nitric Oxide Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70199506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Injectable+formulation+of+disodium+1-%5B2-%28carboxylato%29pyrrolidin-1-yl%5Ddiazen-1-ium-1%2C2-diolate+%28PROLI%2FNO%29%2C+an+ultrafast+nitric+oxide+donor+prodrug.&rft.au=Waterhouse%2C+David+J%3BSaavedra%2C+Joseph+E%3BDavies%2C+Keith+M%3BCitro%2C+Michael+L%3BXu%2C+Xia%3BPowell%2C+Douglas+A%3BGrimes%2C+George+J%3BPotti%2C+Gopal+K%3BKeefer%2C+Larry+K&rft.aulast=Waterhouse&rft.aufirst=David&rft.date=2006-01-01&rft.volume=95&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-29 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chloride-sensitive MEQ fluorescence in chick embryo motoneurons following manipulations of chloride and during spontaneous network activity. AN - 70197881; 16192339 AB - Intracellular Cl(-) ([Cl(-)](in)) homeostasis is thought to be an important regulator of spontaneous activity in the spinal cord of the chick embryo. We investigated this idea by visualizing the variations of [Cl(-)](in) in motoneurons retrogradely labeled with the Cl-sensitive dye 6-methoxy-N-ethylquinolinium iodide (MEQ) applied to cut muscle nerves in the isolated E10-E12 spinal cord. This labeling procedure obviated the need for synthesizing the reduced, cell-permeable dihydro-MEQ (DiH-MEQ). The specificity of motoneuron labeling was confirmed using retrograde co-labeling with Texas Red Dextran and immunocytochemistry for choline acetyltransferase (ChAT). In MEQ-labeled motoneurons, the GABA(A) receptor agonist isoguvacine (100 muM) increased somatic and dendritic fluorescence by 7.4 and 16.7%, respectively. The time course of this fluorescence change mirrored that of the depolarization recorded from the axons of the labeled motoneurons. Blockade of the inward Na(+)/K(-)/2Cl(-) co-transporter (NKCC1) with bumetanide (20 microM) or with a low-Na(+) bath solution (12 mM), increased MEQ fluorescence by 5.3 and 11.4%, respectively, consistent with a decrease of [Cl(-)](in). After spontaneous episodes of activity, MEQ fluorescence increased and then declined to the pre-episode level during the interepisode interval. The largest fluorescence changes occurred over motoneuron dendrites (19.7%) with significantly smaller changes (5.2%) over somata. Collectively, these results show that retrogradely loaded MEQ can be used to detect [Cl(-)](in) in motoneurons, that the bumetanide-sensitive NKCC1 co-transporter is at least partially responsible for the elevated [Cl(-)](in) of developing motoneurons, and that dendritic [Cl(-)](in) decreases during spontaneous episodes and recovers during the inter-episode interval, presumably due to the action of NKCC1. JF - Journal of neurophysiology AU - Chub, Nikolai AU - Mentis, George Z AU - O'donovan, Michael J AD - Laboratory of Neural Control, NINDS/NIH, Rm. 3BC911, 35 Convent Dr., Bethesda, MD 20892-3700, USA. chubn@ninds.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 323 EP - 330 VL - 95 IS - 1 SN - 0022-3077, 0022-3077 KW - Hydroxyquinolines KW - 0 KW - Sodium-Potassium-Chloride Symporters KW - Solute Carrier Family 12, Member 2 KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - Ion Channel Gating -- physiology KW - Animals KW - Chick Embryo KW - Microscopy, Fluorescence -- methods KW - Spinal Cord -- physiology KW - Spinal Cord -- embryology KW - Action Potentials -- physiology KW - Motor Neurons -- physiology KW - Sodium-Potassium-Chloride Symporters -- metabolism KW - Biological Clocks -- physiology KW - Chlorine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70197881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Chloride-sensitive+MEQ+fluorescence+in+chick+embryo+motoneurons+following+manipulations+of+chloride+and+during+spontaneous+network+activity.&rft.au=Chub%2C+Nikolai%3BMentis%2C+George+Z%3BO%27donovan%2C+Michael+J&rft.aulast=Chub&rft.aufirst=Nikolai&rft.date=2006-01-01&rft.volume=95&rft.issue=1&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-20 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. AN - 70195848; 16320087 AB - The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signal transduction pathway has been implicated in some forms of learning and memory. Recent findings suggest that inhibition of phosphodiesterase (PDE) enzymes that degrade cGMP may have memory-enhancing effects. We examined whether treatment with sildenafil citrate, a PDE type 5 inhibitor, would attenuate a learning impairment induced by inhibition of NO synthase [60 mg/kg N(omega)-nitro-L-arginine methyl ester (L-NAME), i.p.]. Rats were pretrained in a one-way active avoidance of foot shock in a straight runway and, on the next day, received 15 training trials in a 14-unit T-maze, a task that has been shown to be sensitive to aging and impairment of central NO signaling systems. Combined treatments of L-NAME or saline and sildenafil (1.0, 1.5, 3.0, or 4.5 mg/kg, i.p.) or vehicle were given 30 and 15 min before training, respectively. Behavioral measures of performance included entries into incorrect maze sections (errors), run time from start to goal (latency), shock frequency, and shock duration. Statistical analysis revealed that L-NAME impaired maze performance and that sildenafil (1.5 mg/kg) significantly attenuated this impairment. Control experiments revealed that administration of L-NAME alone did not significantly increase latencies in a one-way active avoidance test and that different doses of sildenafil alone did not significantly alter complex maze performance. The results indicate that sildenafil may improve learning by modulating NO-cGMP signal transduction, a pathway implicated in age-related cognitive decline and neurodegenerative disease. JF - Psychopharmacology AU - Devan, Bryan D AU - Bowker, Jonna L AU - Duffy, Kara B AU - Bharati, Ila S AU - Jimenez, Mariana AU - Sierra-Mercado, Demetrio AU - Nelson, Christopher M AU - Spangler, Edward L AU - Ingram, Donald K AD - Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. DevanBr@grc.nia.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 439 EP - 445 VL - 183 IS - 4 SN - 0033-3158, 0033-3158 KW - Enzyme Inhibitors KW - 0 KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Sulfones KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cyclic GMP KW - H2D2X058MU KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Signal Transduction -- drug effects KW - Cyclic GMP -- physiology KW - Electroshock KW - Male KW - Phosphodiesterase Inhibitors -- pharmacology KW - Maze Learning -- drug effects KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Learning Disorders -- psychology KW - Piperazines -- pharmacology KW - Learning Disorders -- drug therapy KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70195848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Phosphodiesterase+inhibition+by+sildenafil+citrate+attenuates+a+maze+learning+impairment+in+rats+induced+by+nitric+oxide+synthase+inhibition.&rft.au=Devan%2C+Bryan+D%3BBowker%2C+Jonna+L%3BDuffy%2C+Kara+B%3BBharati%2C+Ila+S%3BJimenez%2C+Mariana%3BSierra-Mercado%2C+Demetrio%3BNelson%2C+Christopher+M%3BSpangler%2C+Edward+L%3BIngram%2C+Donald+K&rft.aulast=Devan&rft.aufirst=Bryan&rft.date=2006-01-01&rft.volume=183&rft.issue=4&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2005-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bi-weekly chemotherapy with cisplatin, epirubicin, folinic acid and 5-fluororacil continuous infusion plus g-csf in advanced gastric cancer: a multicentric phase II study. AN - 70190701; 16001173 AB - It has been demonstrated that the 3-weekly PELF regimen is superior to FAM and FAMTX in advanced gastric cancer. The aim of this multicentric phase II study was to evaluate the efficacy and tolerability of a PELF regimen, given every 2 weeks as a first-line therapy in patients with unresectable or metastatic gastric carcinoma. Fifty-nine patients were treated with the following schedule: cisplatin (40 mg/m2, day 1), epirubicin (30 mg/m2, day 1), 5-fluorouracil (400 mg/m2 bolus, followed by 600 mg/m2, 22 h continuous infusion, day 1 and 2) and folinic acid (100 mg/m2, 2-h infusion, day 1 and 2). G-CSF (5 microg/kg) was administered on day 6, 8, 10, and 12. Cycles were repeated every 2 weeks for a maximum of twelve courses. Of the 52 evaluable patients, three (5.8%) complete responses, and 15 (28.8%) partial responses were observed, for an overall response rate of 34.6%. The median duration of response was 8 months. Nineteen patients had stable disease and 15 progressed on therapy. At a median follow-up of 12 months, the median time to progression was 8 months and the median survival duration was 13 months, with a 1-year survival rate of 53.5%. Grade 3 or 4 observed toxicities were: neutropenia in 26 patients (44%), thrombocytopenia in four patients (6.7%), and mucositis in seven patients (11.9%). The bi-weekly PELF regimen seems to be feasible with an acceptable toxicity profile and an activity comparable to the 3-weekly schedule. JF - Cancer chemotherapy and pharmacology AU - Felici, Alessandra AU - Carlini, Paolo AU - Ruggeri, Enzo Maria AU - Gamucci, Teresa AU - Pollera, Camillo Franco AU - De Marco, Salvatore AU - Fariello, Anna Maria AU - Moscetti, Luca AU - Gelibter, Alain AU - Adami, Ennio AU - Sperduti, Isabella AU - Cognetti, Francesco AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Roma, Italy. alefelici@yahoo.it Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 59 EP - 64 VL - 57 IS - 1 SN - 0344-5704, 0344-5704 KW - Recombinant Proteins KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Epirubicin KW - 3Z8479ZZ5X KW - Cisplatin KW - Q20Q21Q62J KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Leucovorin -- administration & dosage KW - Aged KW - Epirubicin -- adverse effects KW - Cisplatin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- therapeutic use KW - Cisplatin -- therapeutic use KW - Fluorouracil -- adverse effects KW - Epirubicin -- therapeutic use KW - Aged, 80 and over KW - Adult KW - Neoplasm Metastasis KW - Epirubicin -- administration & dosage KW - Time Factors KW - Male KW - Drug Administration Schedule KW - Granulocyte Colony-Stimulating Factor -- therapeutic use KW - Infusions, Intravenous KW - Granulocyte Colony-Stimulating Factor -- adverse effects KW - Leucovorin -- adverse effects KW - Middle Aged KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Cisplatin -- adverse effects KW - Female KW - Leucovorin -- therapeutic use KW - Stomach Neoplasms -- drug therapy KW - Stomach Neoplasms -- pathology KW - Stomach Neoplasms -- mortality KW - Adenocarcinoma -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70190701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Bi-weekly+chemotherapy+with+cisplatin%2C+epirubicin%2C+folinic+acid+and+5-fluororacil+continuous+infusion+plus+g-csf+in+advanced+gastric+cancer%3A+a+multicentric+phase+II+study.&rft.au=Felici%2C+Alessandra%3BCarlini%2C+Paolo%3BRuggeri%2C+Enzo+Maria%3BGamucci%2C+Teresa%3BPollera%2C+Camillo+Franco%3BDe+Marco%2C+Salvatore%3BFariello%2C+Anna+Maria%3BMoscetti%2C+Luca%3BGelibter%2C+Alain%3BAdami%2C+Ennio%3BSperduti%2C+Isabella%3BCognetti%2C+Francesco&rft.aulast=Felici&rft.aufirst=Alessandra&rft.date=2006-01-01&rft.volume=57&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells. AN - 70187202; 16206198 AB - Chemokines (chemoattractant cytokines) and their receptors are present in the brain and may play roles in both neurodevelopment and neuropathology. Increased brain levels of monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, are found in patients with human immunodeficiency virus type 1 (HIV-1)-associated dementia and other acute and chronic neurologic diseases. Although the function of CCL2 in the brain is unclear, it is believed that upregulation of this chemokine during neuropathologic or neuroinflammatory conditions leads to recruitment of activated monocytes into the brain, where they differentiate into macrophages producing neurotoxic and inflammatory molecules. We recently showed that human fetal brain-derived progenitor cells are susceptible to HIV-1 and JC virus infection, and that differentiation toward an astrocyte phenotype increased virus production from these cells. In the current study, we found that in the absence of infection, progenitors produced moderate levels of CCL2 (5.6 ng per million cells). Astrocyte differentiation over 3 weeks increased CCL2 protein levels 30-fold in a biphasic manner, whereas neuronal differentiation decreased production 20-fold. Electromobility shift assays (EMSAs) demonstrated increased nuclear NF-kappaB levels within 2 h of initiating astrocyte differentiation, and inhibitors of NF-kappaB activation partially blocked the CCL2 increase in differentiating astrocytes. Transfection of progenitors with mutated CCL2 promoter/CAT reporter constructs showed that the distal promoter region, containing NF-kappaB and NF-I binding sites, is important for differentiation-induced CCL2 upregulation. Together these results suggest that the transcription factor NF-kappaB, and possibly NF-I, contribute to the upregulation of CCL2 chemokine production during the differentiation of human progenitor cells toward an astrocyte phenotype. (c) 2005 Wiley-Liss, Inc. JF - Glia AU - Lawrence, Diane M P AU - Seth, Pankaj AU - Durham, Linda AU - Diaz, Frank AU - Boursiquot, Roosevelt AU - Ransohoff, Richard M AU - Major, Eugene O AD - Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 81 EP - 91 VL - 53 IS - 1 SN - 0894-1491, 0894-1491 KW - CCL2 protein, human KW - 0 KW - Chemokine CCL2 KW - NF-kappa B KW - NFI Transcription Factors KW - Index Medicus KW - Polyomavirus Infections -- physiopathology KW - HIV-1 -- immunology KW - Polyomavirus Infections -- metabolism KW - Humans KW - AIDS Dementia Complex -- immunology KW - NFI Transcription Factors -- genetics KW - JC Virus -- immunology KW - Phenotype KW - HIV-1 -- metabolism KW - Tumor Virus Infections -- physiopathology KW - Transcriptional Activation -- physiology KW - Promoter Regions, Genetic -- genetics KW - Polyomavirus Infections -- immunology KW - Chemotaxis -- immunology KW - AIDS Dementia Complex -- physiopathology KW - Tumor Virus Infections -- immunology KW - Binding Sites -- physiology KW - NF-kappa B -- genetics KW - JC Virus -- metabolism KW - Chemotaxis -- genetics KW - AIDS Dementia Complex -- metabolism KW - Cells, Cultured KW - Tumor Virus Infections -- metabolism KW - NFI Transcription Factors -- metabolism KW - NF-kappa B -- metabolism KW - Central Nervous System -- metabolism KW - Chemokine CCL2 -- genetics KW - Astrocytes -- cytology KW - Central Nervous System -- embryology KW - Cell Differentiation -- genetics KW - Up-Regulation -- genetics KW - Stem Cells -- metabolism KW - Astrocytes -- immunology KW - Chemokine CCL2 -- metabolism KW - Cell Differentiation -- immunology KW - Stem Cells -- immunology KW - Stem Cells -- cytology KW - Up-Regulation -- immunology KW - Central Nervous System -- cytology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70187202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Astrocyte+differentiation+selectively+upregulates+CCL2%2Fmonocyte+chemoattractant+protein-1+in+cultured+human+brain-derived+progenitor+cells.&rft.au=Lawrence%2C+Diane+M+P%3BSeth%2C+Pankaj%3BDurham%2C+Linda%3BDiaz%2C+Frank%3BBoursiquot%2C+Roosevelt%3BRansohoff%2C+Richard+M%3BMajor%2C+Eugene+O&rft.aulast=Lawrence&rft.aufirst=Diane+M&rft.date=2006-01-01&rft.volume=53&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2005-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a]anthracene. AN - 70187055; 16003757 AB - Identification of molecular markers of early-stage breast cancer development is important for the diagnosis and prevention of the disease. In the present study, we used microarray analysis to examine the differential expression of genes in the rat mammary gland soon after treatment with a known chemical carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), and prior to tumor development. Six weeks after DMBA, differential expression of multiple genes involved in cell growth, differentiation and microtubule dynamics were observed. Gene expression changes were further validated by a combination of techniques, including real-time PCR, RT-PCR, Western blotting and immunohistochemistry. An inhibition of differentiation in this early stage was suggested by the lower expression of beta-casein and transferrin and higher expression of hsp27 in glands from DMBA-treated rats. Possible cell cycle deregulation was indicated by an increased expression of cyclin D1 and hsp86, a heat shock protein associated with cyclin D1. Prior to tumor development, DMBA increased cellular proliferation as detected by Ki-67 and stathmin immunostaining in histologically normal mammary gland. Genes regulating microtubule function, including stathmin, Ran, alpha-tubulin and hsp27, were all overexpressed in the mammary gland of DMBA-treated rats, raising the possibility that disruption of microtubule dynamics and abnormal mitosis may be critical events preceding breast cancer development. Several of the altered proteins, including hsp27, hsp86 and stathmin, may ultimately serve as markers of early breast cancer development. Published 2005 Wiley-Liss, Inc. JF - International journal of cancer AU - Papaconstantinou, Andriana D AU - Shanmugam, Ilanchezhian AU - Shan, Liang AU - Schroeder, Insa S AU - Qiu, Cunping AU - Yu, Minshu AU - Snyderwine, Elizabeth G AD - Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 17 EP - 24 VL - 118 IS - 1 SN - 0020-7136, 0020-7136 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Oligonucleotide Array Sequence Analysis KW - Biomarkers, Tumor -- analysis KW - Cell Differentiation KW - Microtubules -- physiology KW - Up-Regulation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Proliferation KW - Immunohistochemistry KW - Female KW - Gene Expression Profiling KW - Mammary Glands, Animal -- drug effects KW - Breast Neoplasms -- physiopathology KW - Mammary Glands, Animal -- physiology KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70187055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Gene+expression+profiling+in+the+mammary+gland+of+rats+treated+with+7%2C12-dimethylbenz%5Ba%5Danthracene.&rft.au=Papaconstantinou%2C+Andriana+D%3BShanmugam%2C+Ilanchezhian%3BShan%2C+Liang%3BSchroeder%2C+Insa+S%3BQiu%2C+Cunping%3BYu%2C+Minshu%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2006-01-01&rft.volume=118&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-13 N1 - Date created - 2005-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathology of immunodeficient mice with naturally occurring murine norovirus infection. AN - 69025844; 17074739 AB - Murine norovirus (MNV) was recently discovered in Rag2-/-/Stat1-/- mice in a U.S. medical research facility. Presently, little is known concerning the epidemiology and natural history of this virus. We studied the pathology of naturally occurring MNV infection in 28 immunodeficient mice of several different genotypes (Rag1-/-/IFNgamma R-/-, OT1 Rag1-/-/IFNgamma R-/-, OT2 Rag1-/-/IFNgamma R-/-, Rag1-/-/Stat1-/-, and Rag2-/-) that were maintained in two U.S. research facilities. The mice were selected for study because sentinel mice housed in their holding rooms had been identified as positive for MNV-specific antibodies during routine screening for infectious agents. Our data indicate that in certain lines of immunodeficient mice, MNV can establish a disseminated infection that is characteristically associated with inflammation in multiple tissues, including liver (hepatitis), lung (focal interstitial pneumonia) and the peritoneal and pleural cavities. In addition, MNV can establish an asymptomatic infection in the mesenteric lymph nodes of Rag2-/- mice. Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV. JF - Toxicologic pathology AU - Ward, Jerrold M AU - Wobus, Christiane E AU - Thackray, Larissa B AU - Erexson, Cindy R AU - Faucette, Larry J AU - Belliot, Gaël AU - Barron, Elyssa L AU - Sosnovtsev, Stanislav V AU - Green, Kim Y AD - Infectious Disease Pathogenesis Section, Comparative Medicine Branch, Division of Intramural Research, NIAID, NIH, Twinbrook III, Bethesda, Maryland 20892-8135, USA. jeward@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 708 EP - 715 VL - 34 IS - 6 SN - 0192-6233, 0192-6233 KW - Antigens, Viral KW - 0 KW - DNA-Binding Proteins KW - RNA, Viral KW - Rag2 protein, mouse KW - Receptors, Interferon KW - STAT1 Transcription Factor KW - Stat1 protein, mouse KW - interferon gamma receptor KW - Index Medicus KW - Models, Animal KW - Animals KW - Liver -- pathology KW - STAT1 Transcription Factor -- genetics KW - Receptors, Interferon -- genetics KW - Academies and Institutes KW - DNA-Binding Proteins -- genetics KW - Lymph Nodes -- pathology KW - Spleen -- pathology KW - Mice KW - Lung -- pathology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Antigens, Viral -- analysis KW - Mice, Knockout KW - Feces -- virology KW - Mice, Inbred C57BL KW - Intestine, Small -- pathology KW - Immunohistochemistry KW - Cell Line KW - RNA, Viral -- analysis KW - Caliciviridae Infections -- virology KW - Norovirus -- immunology KW - Rodent Diseases -- immunology KW - Caliciviridae Infections -- pathology KW - Norovirus -- isolation & purification KW - Norovirus -- genetics KW - Caliciviridae Infections -- veterinary KW - Caliciviridae Infections -- immunology KW - Immunocompromised Host -- genetics KW - Rodent Diseases -- virology KW - Rodent Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Pathology+of+immunodeficient+mice+with+naturally+occurring+murine+norovirus+infection.&rft.au=Ward%2C+Jerrold+M%3BWobus%2C+Christiane+E%3BThackray%2C+Larissa+B%3BErexson%2C+Cindy+R%3BFaucette%2C+Larry+J%3BBelliot%2C+Ga%C3%ABl%3BBarron%2C+Elyssa+L%3BSosnovtsev%2C+Stanislav+V%3BGreen%2C+Kim+Y&rft.aulast=Ward&rft.aufirst=Jerrold&rft.date=2006-01-01&rft.volume=34&rft.issue=6&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-19 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Controversy revisited: Selective serotonin reuptake inhibitors in paediatric depression. AN - 69016425; 17071546 AB - Selective serotonin reuptake inhibitors (SSRIs) are currently controversial treatments for paediatric depression. There have been several publications on the subject during recent years. This article summarizes their findings and provides some original thoughts, suggestions, and perspectives. Important and relevant articles presenting original data and published in leading journals during 2003-2005 were identified through a PubMed search. Articles instructive in content were selected. A narrative sequence is used to review the field, build arguments, and propound views. Ten principal and several other auxiliary studies were identified for scrutiny. The findings of these studies suggest that published clinical trials of SSRIs in paediatric depression have overstated the antidepressant benefits and understated the risks of suicidal ideation and behaviour arising with treatment; the unpublished clinical trial data are even more unfavourable. Nevertheless, the clinical, epidemiological, and forensic data do suggest overall safety and efficacy of the SSRIs, amongst which fluoxetine may have the best risk-benefit profile. Psychotherapeutic interventions may not always be feasible or effective, especially when depression is more severe. The failure to prescribe a drug may, at the very least, lead to the loss of the placebo effect. It is therefore suggested that, if the diagnosis of unipolar depression is confident, appropriate doses of fluoxetine may be prescribed to depressed children and adolescents; the use of rescue medication to treat emergent agitation is important, and augmentation with psychotherapy may further improve outcomes. The monitoring of indices of growth may also be necessary. JF - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry AU - Andrade, Chittaranjan AU - Bhakta, Savita G AU - Singh, Nagendra M AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India. andrade@nimhans.kar.nic.in Y1 - 2006 PY - 2006 DA - 2006 SP - 251 EP - 260 VL - 7 IS - 4 SN - 1562-2975, 1562-2975 KW - Serotonin Uptake Inhibitors KW - 0 KW - Fluoxetine KW - 01K63SUP8D KW - Index Medicus KW - Fluoxetine -- adverse effects KW - Child Behavior -- psychology KW - Humans KW - Child Behavior -- drug effects KW - Clinical Trials as Topic KW - Fluoxetine -- therapeutic use KW - Child KW - Adolescent KW - Suicide -- psychology KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder -- drug therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69016425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+world+journal+of+biological+psychiatry+%3A+the+official+journal+of+the+World+Federation+of+Societies+of+Biological+Psychiatry&rft.atitle=Controversy+revisited%3A+Selective+serotonin+reuptake+inhibitors+in+paediatric+depression.&rft.au=Andrade%2C+Chittaranjan%3BBhakta%2C+Savita+G%3BSingh%2C+Nagendra+M&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2006-01-01&rft.volume=7&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=The+world+journal+of+biological+psychiatry+%3A+the+official+journal+of+the+World+Federation+of+Societies+of+Biological+Psychiatry&rft.issn=15622975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-23 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced histopathology of the thymus. AN - 69006751; 17067951 AB - The thymus is a primary or central lymphoid organ in which T lymphocytes undergo differentiation and maturation autonomously within the cortex, without the need for antigenic stimulation, and it is essential for the normal development and function of the immune system. The thymus has been shown to be a sensitive target organ following exposure to immunotoxicants and endogenous corticosteroids, and a decrease in size or weight is often one of the first noted measures of compound-induced effects with cortical lymphocytes (thymocytes) being especially susceptible. Therefore, changes in thymus histopathology and architecture are considered to be of particular relevance for immunotoxicity screening. The separate compartments in each lymphoid organ should be evaluated separately and descriptive rather than interpretive terminology should be used to characterize changes within those compartments (Haley et al., 2005). Therefore, enhanced histopathological evaluation of the thymus involves the determination of the size and cellularity of the cortex and medulla, which should be noted separately. Other changes to evaluate include, but are not limited to, increased lymphocyte apoptosis, lymphocyte necrosis, cortex:medulla ratio and an increase or decrease in the epithelial component of the thymus. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 656 EP - 665 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Immunotoxins -- adverse effects KW - Mice KW - T-Lymphocytes -- pathology KW - Cell Death -- drug effects KW - Thymus Gland -- pathology KW - Thymus Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69006751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Enhanced+histopathology+of+the+thymus.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Jan 17;142(3):213-9 [10667892] Toxicol Pathol. 2000 May-Jun;28(3):454-66 [10862566] Microsc Microanal. 2002 Oct;8(5):375-91 [12533214] Vet Pathol. 2003 Sep;40(5):481-95 [12949404] Int Immunopharmacol. 2004 Feb;4(2):213-21 [14996413] Am J Anat. 1984 Jul;170(3):311-30 [6332520] Toxicol Pathol. 2006;34(5):504-14 [17067941] Immunology. 1990 May;70(1):66-74 [2191917] Int J Immunopharmacol. 1992 Apr;14(3):369-75 [1618591] Dev Immunol. 1993;3(2):113-22 [8298300] Toxicol Pathol. 1999 Jul-Aug;27(4):484-90 [10485836] Toxicol Sci. 2004 Dec;82(2):504-14 [15342959] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] J Endocrinol. 1987 Mar;112(3):345-50 [2951474] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histopathology of the lymph nodes. AN - 69006713; 17067938 AB - Lymph nodes function as filters of tissues and tissue fluids and are sites of origin and production of lymphocytes for normal physiological functions. As part of this normal function, they react to both endogenous and exogenous substances with a variety of specific morphological and functional responses. Lesions can be both proliferative and nonproliferative, and can be treatment-related or not. The histological evaluation of lymph nodes is necessary in order to understand the immunotoxic effects of chemicals with the resulting data providing an important component of human risk assessment. It is the challenge of the toxicologic pathologist to interpret the pathology data within the complete clinical evaluation of the entire animal. Daily insults, ageing and toxins can alter the normal histology and primary function of lymph nodes. Therefore it is important to distinguish and differentiate lesions that occur naturally during normal development and ageing from those that are induced by xenobiotics. To achieve this goal, comparison with strain- age- and sex-matched controls is crucial. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 425 EP - 454 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Index Medicus KW - Rats KW - Animals KW - Mice KW - Lymph Nodes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69006713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Histopathology+of+the+lymph+nodes.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2002 Jul 1;100(1):246-58 [12070034] Immunology. 1969 Sep;17(3):481-7 [4900765] J Anat. 1971 Sep;109(Pt 3):369-83 [5153800] Am J Anat. 1982 Aug;164(4):275-309 [7137050] Toxicol Pathol. 1991;19(2):123-7 [1771365] Toxicol Pathol. 1991;19(2):88-97 [1722903] Toxicol Pathol. 2006;34(5):634-47 [17067949] J Natl Cancer Inst. 1960 Oct;25:847-61 [13737512] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] Exp Toxicol Pathol. 2005 Aug;57(1):1-5 [16089314] J Immunol Methods. 2006 May 30;312(1-2):12-9 [16624319] Toxicol Pathol. 2006;34(5):409-24 [17067937] Toxicol Pathol. 2006;34(5):466-503 [17067940] Vet Pathol. 1993 Nov;30(6):560-5 [8116150] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced histopathology of the spleen. AN - 69005482; 17067950 AB - The spleen is the largest secondary lymphoid organ, is considered the draining site for compounds that are administered intravenously, and is therefore considered an important organ to evaluate for treatment-related lesions. Due to the presence of B and T lymphocytes, the immunotoxic effects of xenobiotics or their metabolites on these cell populations may be reflected in the spleen. Therefore it is one of the recommended organs to evaluate for enhanced histopathology of the immune system. The two major functional zones of the spleen are the hematogenous red pulp and the lymphoid white pulp (periarteriolar sheaths, follicles and marginal zones). For enhanced histopathology, these splenic compartments should be evaluated separately for changes in size and cellularity, and descriptive rather than interpretive terminology should be used to characterize any changes (Haley et al., 2005). Moreover, germinal center development within the lymphoid follicles should be noted as increased or decreased. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 648 EP - 655 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Rats KW - B-Lymphocytes -- drug effects KW - Animals KW - B-Lymphocytes -- pathology KW - Immunotoxins -- adverse effects KW - Mice KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- pathology KW - Spleen -- pathology KW - Spleen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69005482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Enhanced+histopathology+of+the+spleen.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Jan 17;142(3):213-9 [10667892] Toxicol Pathol. 2000 May-Jun;28(3):454-66 [10862566] Fundam Appl Toxicol. 1992 Feb;18(2):200-10 [1534777] Inflamm Res. 1996 Dec;45 Suppl 2:S74-8 [8988406] Toxicol Sci. 2004 Dec;82(2):504-14 [15342959] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] Toxicol Pathol. 2006;34(5):455-65 [17067939] Toxicol Pathol. 2006;34(5):466-503 [17067940] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histopathology of bone marrow. AN - 69005288; 17067944 AB - As a major hematopoietic and lymphoid organ, morphological evaluation of the bone marrow is an important component of toxicity or safety assessment studies. While definitive characterization of bone marrow lesions often requires cytological aspirates or smears, assessment of histological bone marrow sections provides information regarding tissue architecture and hematopoietic status that is relevant for the detection of direct or indirect responses to chemical exposure. A variety of lesions have been observed in bone marrow. For example, lesions involving disturbances in growth, degenerative changes, inflammatory changes and neoplasia have been described. Lesions identified in hematoxylin and eosin-stained sections typically represent changes in the hematopoietic cell lineage and/or stromal cells since definitive identification of lymphoid cells is difficult except in cases of lymphoma. This review provides a descriptive and pictorial representation of a wide range of bone marrow lesions. Since large animal-to-animal variation may exist and there can be collection site- and age-related differences, it is imperative that the pathologist reviews all potential treatment-related findings against appropriate concurrent controls. JF - Toxicologic pathology AU - Travlos, Gregory S AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. travlos@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 566 EP - 598 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Index Medicus KW - Rats KW - Animals KW - Bone Marrow Cells -- pathology KW - Mice KW - Bone Marrow -- pathology KW - Bone Marrow Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69005288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Histopathology+of+bone+marrow.&rft.au=Travlos%2C+Gregory+S&rft.aulast=Travlos&rft.aufirst=Gregory&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunohistochemical markers for the rodent immune system. AN - 69004794; 17067947 AB - The responses to insults including chemical toxins, irradiation and infectious agents involve morphologic, biochemical and molecular changes in the immune system. The changes in specific tissues and cells often can be detected by histopathology and its associated field of immunohistochemistry (IHC). Cells normally express specific proteins (antigens) that can be detected by IHC. When responses to xenobiotics occur, cells often up or down regulate proteins. The art of IHC requires specialized procedures for detection of antigens. Fixation, tissue processing, immunoreactions and antigen retrieval methods are important elements of IHC. We review the antibodies, their sources, use of frozen or fixed paraffin-embedded tissues and specific IHC methods including antigen retrieval and illustrate how they can be effectively used to characterize the immunotoxicologic effects of agents. JF - Toxicologic pathology AU - Ward, Jerrold M AU - Erexson, Cindy R AU - Faucette, Lawrence J AU - Foley, Julie F AU - Dijkstra, Christine AU - Cattoretti, Giorgio AD - Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases/NIH, Bethesda, MD 20892-8135, USA. jw116y@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 616 EP - 630 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Biomarkers KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Mice KW - Immune System -- metabolism KW - Biomarkers -- analysis KW - Immunohistochemistry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69004794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Immunohistochemical+markers+for+the+rodent+immune+system.&rft.au=Ward%2C+Jerrold+M%3BErexson%2C+Cindy+R%3BFaucette%2C+Lawrence+J%3BFoley%2C+Julie+F%3BDijkstra%2C+Christine%3BCattoretti%2C+Giorgio&rft.aulast=Ward&rft.aufirst=Jerrold&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced histopathology of the lymph nodes. AN - 69004691; 17067949 AB - Routine histopathology of lymphoid organs is the cornerstone in the identification of immunotoxic and immunomodulatory compounds. Enhanced histopathology is a systematic approach that can be used to further characterize, both qualitatively and semi-quantitatively, the immunomodulatory effects that may occur within both primary and secondary lymphoid organs. The lymph nodes are the major route of entry for antigens and pathogens, via the afferent lymph flow, and they can be sensitive indicators of compounds with regional or systemic immunomodulatory/toxic effects and should therefore be included in the battery of lymphoid organs to evaluate for enhanced histopathology. As with all lymphoid organs, the separate compartments should be evaluated independently and descriptive rather than interpretive terminology should be used to characterize changes within those compartments. This data, in conjunction with gross findings, clinical pathology and changes in organ weight (i.e., thymus), will enable the pathologist to determine if a significant effect on the immune system is present. Moreover, this data may enable the pathologist to determine the critical site or compartment in the targeted tissue, provide some indication of target cell population (B or T cell) and characterize a dose-response relationship. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 634 EP - 647 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Rats KW - Histological Techniques KW - Animals KW - Macaca fascicularis KW - Immunotoxins -- adverse effects KW - Dogs KW - Mice KW - Lymph Nodes -- pathology KW - Lymph Nodes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69004691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Enhanced+histopathology+of+the+lymph+nodes.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Jan 17;142(3):213-9 [10667892] J Anat. 1971 Sep;109(Pt 3):369-83 [5153800] Toxicol Pathol. 2006;34(5):409-24 [17067937] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] Am J Anat. 1982 Aug;164(4):275-309 [7137050] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced histopathology of mucosa-associated lymphoid tissue. AN - 69004459; 17067953 AB - The secretory epithelial surfaces of the body are a major route of entry for potentially pathogenic substances. The organized mucosal lymphoid tissues that are found within the gastrointestinal and respiratory tracts are therefore particularly important as a first line of defense against harmful compounds. The major function of these mucosa-associated lymphoid tissues (MALT) is to initiate local IgA immune responses, which are then passed on to draining lymph nodes. For enhanced histopathology, the separate compartments of each lymphoid tissue should be evaluated separately for changes in size and lymphocyte cellularity and descriptive rather than interpretive terminology should be used to characterize any changes. The organization of MALT is similar to that of lymph nodes with B-cell-rich follicles and T-cell-rich interfollicular areas. Therefore, these two compartments should be evaluated separately for changes in size and lymphocyte cellularity and the germinal center development within lymphoid follicles should be evaluated as well. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 687 EP - 696 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Rats KW - Histological Techniques KW - Animals KW - Immunotoxins -- adverse effects KW - Mice KW - Lymphoid Tissue -- pathology KW - Mucous Membrane -- immunology KW - Mucous Membrane -- pathology KW - Mucous Membrane -- drug effects KW - Lymphoid Tissue -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69004459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Enhanced+histopathology+of+mucosa-associated+lymphoid+tissue.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2003 Jun 3;188(1):49-71 [12748041] Lab Anim. 1981 Jan;15(1):57-9 [7022018] Cell Tissue Res. 1986;245(2):439-44 [3527428] Toxicol Pathol. 2006;34(5):599-608 [17067945] Cell Tissue Res. 1990 Feb;259(2):371-7 [2337928] Toxicol Pathol. 1991;19(4 Pt 1):321-36 [1813979] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] Immunology. 1988 Apr;63(4):657-62 [3259206] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors. AN - 69003972; 17067963 AB - Ribose ring-constrained nucleosides and nucleotides to act at cell-surface purine recesptors have been designed and synthesized. At the P2Y1 nucleotide receptor and the A3 adenosine receptor (AR) the North envelope conformation of ribose is highly preferred. We have applied mutagenesis and rhodopsin-based homology modeling to the study of purine receptors and used the structural insights gained to assist in the design of novel ligands. Two subgroups of P2Y receptors have been defined, containing different sets of cationic residues for coordinating the phosphate groups. Modeling/mutagenesis of adenosine receptors has focused on determinants of intrinsic efficacy in adenosine derivatives and on a conserved Trp residue (6.48) which is involved in the activation process. The clinical use of adenosine agonists as cytoprotective agents has been limited by the widespread occurrence of ARs, thus, leading to undesirable side effects of exogenously administered adenosine derivatives. In order to overcome the inherent nonselectivity of activating the native receptors, we have introduced the concept of neoceptors. By this strategy, intended for eventual use in gene therapy, the putative ligand binding site of a G protein-coupled receptor is reengineered for activation by synthetic agonists (neoligands) built to have a structural complementarity. Using a rational design process we have identified neoceptor-neoligand pairs which are pharmacologically orthogonal with respect to the native species. JF - Nucleosides, nucleotides & nucleic acids AU - Jacobson, Kenneth A AU - Costanzi, Stefano AU - Kim, Soo-Kyung AU - Roh, Eunjoo AU - Joshi, Bhalchandra V AU - Tchilibon, Susanna AU - Duong, Heng T AU - Gao, Zhan-Guo AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA. kajacobs@helix.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1425 EP - 1436 VL - 25 IS - 12 SN - 1525-7770, 1525-7770 KW - Cations KW - 0 KW - Ligands KW - Nucleosides KW - Nucleotides KW - P2RY1 protein, human KW - Purines KW - Receptor, Adenosine A3 KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2Y1 KW - Ribose KW - 681HV46001 KW - Index Medicus KW - Animals KW - Receptor, Adenosine A3 -- chemistry KW - Models, Molecular KW - Humans KW - Receptors, Purinergic P2 -- chemistry KW - Ribose -- chemistry KW - Genetic Therapy -- methods KW - Models, Chemical KW - Cell Membrane -- metabolism KW - Molecular Conformation KW - Purines -- chemistry KW - Nucleotides -- chemistry KW - Nucleosides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69003972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleosides%2C+nucleotides+%26+nucleic+acids&rft.atitle=Action+of+nucleosides+and+nucleotides+at+7+transmembrane-spanning+receptors.&rft.au=Jacobson%2C+Kenneth+A%3BCostanzi%2C+Stefano%3BKim%2C+Soo-Kyung%3BRoh%2C+Eunjoo%3BJoshi%2C+Bhalchandra+V%3BTchilibon%2C+Susanna%3BDuong%2C+Heng+T%3BGao%2C+Zhan-Guo&rft.aulast=Jacobson&rft.aufirst=Kenneth&rft.date=2006-01-01&rft.volume=25&rft.issue=12&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Nucleosides%2C+nucleotides+%26+nucleic+acids&rft.issn=15257770&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-30 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced histopathology of the bone marrow. AN - 69003750; 17067952 AB - Changes in bone marrow cellularity can be an indicator of systemic toxicity and, therefore, bone marrow should be included in the battery of tissues examined for enhanced histopathology. However, the majority of changes in the bone marrow that are observed in toxicology studies are a response to hematological changes or lesions elsewhere in the body. For this reason, a consideration of all tissue changes in the body is required in order to differentiate toxic effects versus physiological responses in the bone marrow. While enhanced histopathology involves evaluation of the separate compartments in each lymphoid organ using descriptive rather than interpretive terminology, bone marrow is unique in that it lacks specific compartments. Furthermore, identification of erythroid, myeloid, megakaryocytic, and stromal cells, plus adipose tissue and hemosiderin-laden macrophages, can be accomplished from conventional H&E-stained sections, but conclusive identification of lymphoid lineage cells is not likely. This limits the extent of initial enhanced histopathology on bone marrow and argues for the use of cytological preparations for more comprehensive assessment of potential immunomodulatory effects. JF - Toxicologic pathology AU - Elmore, Susan A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 666 EP - 686 VL - 34 IS - 5 SN - 0192-6233, 0192-6233 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Immunotoxins -- adverse effects KW - Dogs KW - Mice KW - Bone Marrow Cells -- drug effects KW - Bone Marrow -- pathology KW - Bone Marrow Diseases -- pathology KW - Bone Marrow Cells -- pathology KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69003750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Enhanced+histopathology+of+the+bone+marrow.&rft.au=Elmore%2C+Susan+A&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Pathol. 2006;34(5):548-65 [17067943] Toxicol Pathol. 2005;33(3):404-7; discussion 408 [15805080] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins. AN - 68970030; 16971464 AB - DNA polymerase zeta (pol zeta) participates in several DNA transactions in eukaryotic cells that increase spontaneous and damage-induced mutagenesis. To better understand this central role in mutagenesis in vivo, here we report the fidelity of DNA synthesis in vitro by yeast pol zeta alone and with RFC, PCNA and RPA. Overall, the accessory proteins have little effect on the fidelity of pol zeta. Pol zeta is relatively accurate for single base insertion/deletion errors. However, the average base substitution fidelity of pol zeta is substantially lower than that of homologous B family pols alpha, delta and epsilon. Pol zeta is particularly error prone for substitutions in specific sequence contexts and generates multiple single base errors clustered in short patches at a rate that is unprecedented in comparison with other polymerases. The unique error specificity of pol zeta in vitro is consistent with Pol zeta-dependent mutagenic specificity reported in vivo. This fact, combined with the high rate of single base substitution errors and complex mutations observed here, indicates that pol zeta contributes to mutagenesis in vivo not only by extending mismatches made by other polymerases, but also by directly generating its own mismatches and then extending them. JF - Nucleic acids research AU - Zhong, Xuejun AU - Garg, Parie AU - Stith, Carrie M AU - Nick McElhinny, Stephanie A AU - Kissling, Grace E AU - Burgers, Peter M J AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 4731 EP - 4742 VL - 34 IS - 17 KW - Nucleotides KW - 0 KW - Proliferating Cell Nuclear Antigen KW - REV7 protein, S cerevisiae KW - Replication Protein A KW - Replication Protein C KW - Saccharomyces cerevisiae Proteins KW - DNA KW - 9007-49-2 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - REV3 protein, S cerevisiae KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Index Medicus KW - Nucleotides -- metabolism KW - Base Sequence KW - Replication Protein C -- metabolism KW - beta-Galactosidase -- genetics KW - Mutation KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Saccharomyces cerevisiae Proteins -- metabolism KW - DNA -- chemistry KW - Replication Protein A -- metabolism KW - DNA -- biosynthesis KW - Mutagenesis KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=The+fidelity+of+DNA+synthesis+by+yeast+DNA+polymerase+zeta+alone+and+with+accessory+proteins.&rft.au=Zhong%2C+Xuejun%3BGarg%2C+Parie%3BStith%2C+Carrie+M%3BNick+McElhinny%2C+Stephanie+A%3BKissling%2C+Grace+E%3BBurgers%2C+Peter+M+J%3BKunkel%2C+Thomas+A&rft.aulast=Zhong&rft.aufirst=Xuejun&rft.date=2006-01-01&rft.volume=34&rft.issue=17&rft.spage=4731&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2006 Feb 2;439(7076):557-62 [16452972] Curr Biol. 2006 Mar 21;16(6):586-90 [16546083] EMBO J. 2006 Mar 22;25(6):1285-94 [16482220] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] J Biol Chem. 2004 Jan 2;279(1):577-84 [14563842] Nature. 2004 Mar 4;428(6978):97-100 [14999287] DNA Repair (Amst). 2004 Apr 1;3(4):395-402 [15010315] Cell Cycle. 2004 May;3(5):580-3 [15118407] J Biol Chem. 2004 Jul 23;279(30):31921-9 [15145936] J Mol Biol. 1968 Jan 28;31(2):291-304 [4865486] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] Genetics. 1980 Dec;96(4):819-39 [7021317] Genetics. 1980 Dec;96(4):841-57 [7021318] Mol Gen Genet. 1984;195(3):487-90 [6381967] J Biol Chem. 1988 Oct 15;263(29):14784-9 [3049589] Genetics. 2005 Feb;169(2):575-82 [15520252] Trends Immunol. 2005 Apr;26(4):215-20 [15797512] Genetics. 2006 Mar;172(3):1487-98 [16387871] Nucleic Acids Res. 2006;34(11):3259-66 [16807316] Nucleic Acids Res. 2006;34(16):4335-41 [16936322] Mol Cell Biol. 1989 Oct;9(10):4447-58 [2555694] J Biol Chem. 1990 Feb 5;265(4):2338-46 [1688852] Biochemistry. 1990 Jun 5;29(22):5226-31 [2166556] Biochemistry. 1991 Dec 24;30(51):11751-9 [1751492] J Biol Chem. 1994 Apr 15;269(15):11121-32 [8157639] Genetics. 1994 Jul;137(3):637-46 [8088509] Science. 1995 Jun 16;268(5217):1616-9 [7777859] Genetics. 1995 Jun;140(2):443-56 [7498727] Methods Enzymol. 1995;262:217-32 [8594349] Science. 1996 Jun 14;272(5268):1646-9 [8658138] Eur J Biochem. 1996 Jun 1;238(2):297-307 [8681938] Cancer Surv. 1996;28:21-31 [8977026] Genetics. 1997 Nov;147(3):1017-24 [9383049] J Biol Chem. 1999 Feb 5;274(6):3642-50 [9920913] Adv Protein Chem. 2004;69:137-65 [15588842] Adv Protein Chem. 2004;69:167-203 [15588843] Adv Protein Chem. 2004;69:205-28 [15588844] FEBS Lett. 2005 Feb 7;579(4):868-72 [15680965] Nature. 2000 Aug 31;406(6799):1015-9 [10984059] J Biol Chem. 2000 Dec 15;275(50):39678-84 [11006276] Mol Cell. 2000 Dec;6(6):1491-9 [11163221] Mutat Res. 2001 Feb 25;485(1):83-92 [11341996] J Biol Chem. 2001 Jan 26;276(4):2317-20 [11113111] Nucleic Acids Res. 2001 Jul 1;29(13):2875-83 [11433034] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Genetics. 2001 Sep;159(1):47-64 [11560886] Genes Dev. 2002 Aug 1;16(15):1872-83 [12154119] Genetics. 2002 Nov;162(3):1003-18 [12454051] Genetics. 2002 Nov;162(3):1063-77 [12454056] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] J Biol Chem. 2003 Jan 17;278(3):1618-25 [12424238] Cold Spring Harb Symp Quant Biol. 2000;65:61-9 [12760021] Cold Spring Harb Symp Quant Biol. 2000;65:81-91 [12760023] Nucleic Acids Res. 2003 Aug 1;31(15):4541-52 [12888515] Mol Cancer Res. 2003 Sep;1(11):836-47 [14517346] Genetics. 2005 Apr;169(4):1939-55 [15687278] Genetics. 2005 Apr;169(4):1815-24 [15695359] J Biol Chem. 2005 May 20;280(20):20051-8 [15778218] Annu Rev Biochem. 2005;74:317-53 [15952890] Annu Rev Biochem. 2005;74:681-710 [15952900] J Biol Chem. 2005 Jun 24;280(25):23446-50 [15879599] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] J Biol Chem. 2005 Nov 18;280(46):38657-65 [16169844] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] DNA Repair (Amst). 2006 Feb 3;5(2):226-34 [16290107] Mutat Res. 2006 Jan 29;593(1-2):187-95 [16154164] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer. AN - 68928314; 17024972 AB - Prostate cancer, the most commonly diagnosed cancer among American men, develops slowly over many years. The long latent period of 20 to 30 years, involved in the multistep process of carcinogenesis, provides an important opportunity to block or reverse progression to a malignant state. Vitamin A (retinoids) and vitamin D not only have the ability to block steps in the process of carcinogenesis but they can also modulate or reverse some malignant characteristics of cancer cells. However, at high levels, vitamins A and D have undesirable side effects, thus, limiting effective dose levels and efficacy. Therefore, combination treatment at low doses, to increase efficacy and avoid toxicity, is of special interest. This study examines the effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in combination with cholecalciferol (vitamin D3) on growth, and on the expression of vimentin, matrix metalloproteinase-2 (MMP-2), and retinoid and vitamin D receptor expression, using the non-tumorigenic, human prostate epithelial cell line RWPE-1. Treatment with 4-HPR and cholecalciferol resulted in synergistic growth inhibition when compared to that caused by each agent alone. A decrease in vimentin expression and MMP-2 activity, and up-regulation of vitamin D receptor (VDR) and some of the retinoid-X (RXRs) and retinoic acid receptor (RARs) subtypes, was observed. These results suggest that combined treatment with 4-HPR and cholecalciferol, at doses lower than what might be effective with single agents, increases their efficacy and suggest that this may serve as an effective strategy for chemoprevention and treatment of prostate cancer. JF - Journal of experimental therapeutics & oncology AU - Tokar, Erik J AU - Ancrile, Brooke B AU - Ablin, Richard J AU - Webber, Mukta M AD - Department of Zoology, Michigan State University, East Lansing 48824, USA. tokare@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 323 EP - 333 VL - 5 IS - 4 SN - 1359-4117, 1359-4117 KW - Anticarcinogenic Agents KW - 0 KW - Retinoids KW - Vimentin KW - Vitamins KW - Fenretinide KW - 187EJ7QEXL KW - Cholecalciferol KW - 1C6V77QF41 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Index Medicus KW - Retinoids -- metabolism KW - Vitamins -- metabolism KW - Humans KW - Vimentin -- metabolism KW - Up-Regulation KW - Matrix Metalloproteinase 2 -- metabolism KW - Male KW - Prostatic Neoplasms -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Fenretinide -- pharmacology KW - Cholecalciferol -- pharmacology KW - Anticarcinogenic Agents -- pharmacology KW - Prostatic Neoplasms -- drug therapy KW - Prostatic Neoplasms -- therapy KW - Drug Synergism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+therapeutics+%26+oncology&rft.atitle=Cholecalciferol+%28vitamin+D3%29+and+the+retinoid+N-%284-hydroxyphenyl%29retinamide+%284-HPR%29+are+synergistic+for+chemoprevention+of+prostate+cancer.&rft.au=Tokar%2C+Erik+J%3BAncrile%2C+Brooke+B%3BAblin%2C+Richard+J%3BWebber%2C+Mukta+M&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2006-01-01&rft.volume=5&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+therapeutics+%26+oncology&rft.issn=13594117&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic potential of monoamine transporter substrates. AN - 68925176; 17017961 AB - Monoamine transporter proteins are targets for many psychoactive compounds, including therapeutic and abused stimulant drugs. This paper reviews recent work from our laboratory investigating the interaction of stimulants with transporters in brain tissue. We illustrate how determining the precise mechanism of stimulant drug action (uptake inhibitor vs. substrate) can provide unique opportunities for medication discovery. An important lesson learned from this work is that drugs which display equipotent substrate activity at dopamine (DA) and serotonin (5-HT) transporters have minimal abuse liability and few stimulant side-effects, yet are able to suppress ongoing drug-seeking behavior. As a specific example, we describe the development of PAL-287 (alpha-methylnapthylethylamine), a dual DA/5-HT releasing agent that suppresses cocaine self-administration in rhesus monkeys, without the adverse effects associated with older phenylethylamine 5-HT releasers (e.g., fenfluramine) and DA releasers (e.g., amphetamine). Our findings demonstrate the feasibility of developing non-amphetamine releasing agents as potential treatments for substance abuse disorders and other psychiatric conditions. JF - Current topics in medicinal chemistry AU - Rothman, Richard B AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. rrothman@intra.nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1845 EP - 1859 VL - 6 IS - 17 KW - Central Nervous System Stimulants KW - 0 KW - Vesicular Monoamine Transport Proteins KW - Index Medicus KW - Animals KW - Humans KW - Substance-Related Disorders -- drug therapy KW - Molecular Conformation KW - Vesicular Monoamine Transport Proteins -- metabolism KW - Central Nervous System Stimulants -- pharmacology KW - Central Nervous System Stimulants -- metabolism KW - Central Nervous System Stimulants -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+topics+in+medicinal+chemistry&rft.atitle=Therapeutic+potential+of+monoamine+transporter+substrates.&rft.au=Rothman%2C+Richard+B%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2006-01-01&rft.volume=6&rft.issue=17&rft.spage=1845&rft.isbn=&rft.btitle=&rft.title=Current+topics+in+medicinal+chemistry&rft.issn=1873-4294&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Discrimination of photon from proton irradiation using glow curve feature extraction and vector analysis. AN - 68878600; 16614091 AB - Two types of thermoluminescence dosemeters (TLDs), the Harshaw LiF:Mg,Ti (TLD-100) and CaF(2):Tm (TLD-300) were investigated for their glow curve response to separate photon and proton irradiations. The TLDs were exposed to gamma irradiation from a (137)Cs source and proton irradiation using a positive ion accelerator. The glow curve peak structure for each individual TLD exposure was deconvolved to obtain peak height, width, and position. Simulated mixed-field glow curves were obtained by superposition of the experimentally obtained single field exposures. Feature vectors were composed of two kinds of features: those from deconvolution and those taken in the neighbourhood of several glow curve peaks. The inner product of the feature vectors was used to discriminate among the pure photon, pure proton and simulated mixed-field irradiations. In the pure cases, identification of radiation types is both straightforward and effective. Mixed-field discrimination did not succeed using deconvolution features, but the peak-neighbourhood features proved to discriminate reliably. JF - Radiation protection dosimetry AU - Skopec, M AU - Loew, M AU - Price, J L AU - Guardala, N AU - Moscovitch, M AD - Department of Diagnostic Radiology, National Institutes of Health, Bethesda, MD, USA. marskopec@yahoo.com Y1 - 2006 PY - 2006 DA - 2006 SP - 268 EP - 272 VL - 120 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Discriminant Analysis KW - Reproducibility of Results KW - Dose-Response Relationship, Radiation KW - Thermoluminescent Dosimetry -- methods KW - Algorithms KW - Pattern Recognition, Automated -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68878600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Discrimination+of+photon+from+proton+irradiation+using+glow+curve+feature+extraction+and+vector+analysis.&rft.au=Skopec%2C+M%3BLoew%2C+M%3BPrice%2C+J+L%3BGuardala%2C+N%3BMoscovitch%2C+M&rft.aulast=Skopec&rft.aufirst=M&rft.date=2006-01-01&rft.volume=120&rft.issue=1-4&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Radiat Prot Dosimetry. 2009 Sep;136(2):132-3; author reply 133-4 [19717634] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - BL22 and lymphoid malignancies. AN - 68876862; 16997177 AB - BL22 is a recombinant immunotoxin containing a truncated form of the bacterial toxin Pseudomonas exotoxin A attached to an Fv fragment of an anti-CD22 monoclonal antibody. Its mechanism of action involves binding to CD22, being internalized into the target cell by endocytosis, being processed to generate a free toxin fragment which is translocated into the cytoplasm, and finally induction of cell death by catalytic inactivation of elongation factor 2. In phase-I testing BL22 was very active in chemoresistant hairy-cell leukemia (HCL), with 19 (61%) of 31 patients achieving complete remission (CR). The low blood counts (cytopenias) which are characteristic of HCL improved in all complete and partial responders. Dose-limiting toxicity in HCL was due to a reversible hemolytic uremic syndrome (HUS), observed only during cycles 2 or 3. Already under way are a phase-II trial in HCL and phase-I trials in chronic lymphocytic leukemia (CLL) and acute lymphocytic leukemia (ALL) administering BL22 in a modified protocol in an effort to prevent HUS. JF - Best practice & research. Clinical haematology AU - Kreitman, Robert J AU - Pastan, Ira AD - Centers for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124b, Bethesda, MD 20892-4255, USA. kreitmar@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 685 EP - 699 VL - 19 IS - 4 SN - 1521-6926, 1521-6926 KW - Antibodies KW - 0 KW - Enterotoxins KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Index Medicus KW - Models, Immunological KW - Clinical Trials, Phase II as Topic KW - Humans KW - Clinical Trials, Phase I as Topic KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Antibodies -- therapeutic use KW - Antibodies -- adverse effects KW - Antibodies -- administration & dosage KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- immunology KW - Enterotoxins -- adverse effects KW - Leukemia, Hairy Cell -- drug therapy KW - Enterotoxins -- therapeutic use KW - Enterotoxins -- administration & dosage KW - Leukemia, Hairy Cell -- immunology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68876862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Best+practice+%26+research.+Clinical+haematology&rft.atitle=BL22+and+lymphoid+malignancies.&rft.au=Kreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=19&rft.issue=4&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Best+practice+%26+research.+Clinical+haematology&rft.issn=15216926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - National cancer institute perspectives. AN - 68867111; 16979449 AB - The National Cancer Institute (NCI) Perspectives this year presented information on the systemic targeted radionuclide therapy (STaRT) research projects: (1) being investigated at the NCI's Intramural Center for Cancer Research; (2) funded by NCI's Radiation Research Program and other extramural programs; and (3) the appropriate National Institutes of Health/NCI funding mechanisms applicable to researchers for obtaining funds for STaRT projects. JF - International journal of radiation oncology, biology, physics AU - Wong, Rosemary S L AU - Brechbiel, Martin W AD - Radiation Research Program, Radiotherapy Development Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. rw26f@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - S96 EP - S99 VL - 66 IS - 2 Suppl SN - 0360-3016, 0360-3016 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Immunotoxins KW - Recombinant Proteins KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - United States KW - Biomedical Research KW - Humans KW - Immunotoxins -- therapeutic use KW - Recombinant Proteins -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Neoplasms -- radiotherapy KW - National Institutes of Health (U.S.) KW - Radioimmunotherapy -- economics KW - Research Support as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68867111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=National+cancer+institute+perspectives.&rft.au=Wong%2C+Rosemary+S+L%3BBrechbiel%2C+Martin+W&rft.aulast=Wong&rft.aufirst=Rosemary+S&rft.date=2006-01-01&rft.volume=66&rft.issue=2+Suppl&rft.spage=S96&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-27 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Matriptase: potent proteolysis on the cell surface. AN - 68804330; 16838070 AB - Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. Activation of the matriptase zymogen requires sequential N-terminal cleavage, activation site autocleavage, and transient association with HAI-1. Matriptase has an essential physiological role in profilaggrin processing, corneocyte maturation, and lipid matrix formation associated with terminal differentiation of the oral epithelium and the epidermis, and is also critical for hair follicle growth. Matriptase and HAI expression are frequently dysregulated in human cancer, and matriptase expression that is unopposed by HAI-1 potently promotes carcinogenesis and metastatic dissemination in animal models. JF - Molecular medicine (Cambridge, Mass.) AU - List, Karin AU - Bugge, Thomas H AU - Szabo, Roman AD - Proteases and Tissue Remodeling Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. thomas.bugge@nih.gov PY - 2006 SP - 1 EP - 7 VL - 12 IS - 1-3 SN - 1076-1551, 1076-1551 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - matriptase KW - Index Medicus KW - Animals KW - Neoplasms -- enzymology KW - Epithelial Cells -- pathology KW - Enzyme Activation KW - Humans KW - Serine Endopeptidases -- metabolism KW - Protein Processing, Post-Translational KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68804330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.atitle=Matriptase%3A+potent+proteolysis+on+the+cell+surface.&rft.au=List%2C+Karin%3BBugge%2C+Thomas+H%3BSzabo%2C+Roman&rft.aulast=List&rft.aufirst=Karin&rft.date=2006-01-01&rft.volume=12&rft.issue=1-3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.issn=10761551&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-13 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2005 Jan;37(1):56-65 [15619623] J Biol Chem. 2004 Nov 5;279(45):46981-94 [15328353] Br J Cancer. 2005 Jan 31;92(2):278-83 [15611789] Am J Physiol Cell Physiol. 2005 Apr;288(4):C932-41 [15590895] Br J Cancer. 2005 Jun 20;92(12):2171-80 [15928670] Am J Physiol Cell Physiol. 2005 Aug;289(2):C462-70 [15800053] Hum Pathol. 2005 Jun;36(6):626-33 [16021568] Biochem J. 2005 Aug 15;390(Pt 1):231-42 [15853774] Oncogene. 2005 Aug 11;24(34):5333-43 [16007225] Genes Dev. 2005 Aug 15;19(16):1934-50 [16103220] Int J Oncol. 2005 Oct;27(4):1061-70 [16142324] EMBO Rep. 2005 Nov;6(11):1045-51 [16170303] World J Gastroenterol. 2005 Oct 21;11(39):6202-7 [16273651] Annu Rev Pharmacol Toxicol. 2006;46:301-15 [16402907] Nat Genet. 2006 Mar;38(3):337-42 [16444271] Am J Pathol. 2006 May;168(5):1513-25 [16651618] Am J Physiol Cell Physiol. 2006 Jul;291(1):C40-9 [16467405] Nat Genet. 2000 Jun;25(2):141-2 [10835624] J Biol Chem. 2000 Aug 25;275(34):26333-42 [10831593] J Biol Chem. 2000 Nov 24;275(47):36720-5 [10962009] J Invest Dermatol. 2000 Dec;115(6):1072-81 [11121144] Tumour Biol. 2001 Mar-Apr;22(2):104-14 [11125283] Am J Pathol. 2001 Apr;158(4):1301-11 [11290548] J Biol Chem. 2001 Nov 30;276(48):44581-9 [11567025] J Biol Chem. 2002 Mar 22;277(12):10539-46 [11792696] Clin Cancer Res. 2002 Apr;8(4):1101-7 [11948120] Oncogene. 2002 May 23;21(23):3765-79 [12032844] J Biol Chem. 2002 Oct 4;277(40):37637-46 [12149247] Clin Exp Metastasis. 2002;19(7):639-49 [12498394] Cancer Res. 2003 Mar 1;63(5):1101-5 [12615728] Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):237-58 [12784999] J Biol Chem. 2003 Jul 18;278(29):26773-9 [12738778] J Histochem Cytochem. 2003 Aug;51(8):1017-25 [12871983] Biochem J. 2003 Aug 1;373(Pt 3):689-702 [12744720] J Biol Chem. 2003 Sep 19;278(38):36341-9 [12815039] Cancer. 2003 Nov 1;98(9):1898-904 [14584072] J Cell Biol. 2003 Nov 24;163(4):901-10 [14638864] Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):202-11 [14734471] J Biol Chem. 2004 Apr 9;279(15):14899-908 [14747469] Am J Physiol Cell Physiol. 2004 May;286(5):C1159-69 [15075215] Chest. 2004 May;125(5):1843-52 [15136399] Prostate. 2004 Nov 1;61(3):228-35 [15368474] Cancer Res. 1993 Mar 15;53(6):1409-15 [8383010] Immunogenetics. 1999 May;49(5):420-8 [10199918] J Biol Chem. 1999 Jun 25;274(26):18231-6 [10373424] J Biol Chem. 1999 Jun 25;274(26):18237-42 [10373425] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11054-61 [10500122] Biochem Biophys Res Commun. 2005 Feb 4;327(1):328-34 [15629466] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrinsic cisplatin resistance in lung and ovarian cancer cells propagating in medium acutely depleted of folate. AN - 68735604; 16898872 AB - Many tumors develop intrinsic and/or acquired resistance to cisplatin. The purpose of the present study was to examine the influence of acute extracellular folate depletion prior to cisplatin treatment on the development of intrinsic cisplatin resistance. Lung and ovarian cancer cells were propagated in medium acutely depleted of folate and subsequently treated with cisplatin. The IC50 level for cisplatin, cell viability, cell proliferation, and global DNA methylation were determined. Gene expression profiling was performed using the Atlas Cancer 1.2 Array. Acute extracellular folate depletion resulted in the development of intrinsic cisplatin resistance. Cells propagating in medium acutely depleted of folate had a survival advantage compared to control cells when exposed to cisplatin, and thymidine supplementation did not reverse the intrinsic cisplatin resistance. cDNA microarray analysis revealed some novel genes associated with the development of intrinsic cisplatin resistance. Our report is the first to demonstrate that acute extracellular folate depletion results in intrinsic cisplatin resistance. If these results are confirmed by in vivo human studies, it would suggest that the folate status of the recipient of cisplatin might have an impact on response to that chemotherapeutic agent. JF - Nutrition and cancer AU - Whiteside, Martin A AU - Piyathilake, Chandrika J AU - Bushell, Tamara M AU - Johanning, Gary L AD - National Cancer Institute, Division of Cancer Prevention, Bethesda, MD 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 274 EP - 284 VL - 54 IS - 2 SN - 0163-5581, 0163-5581 KW - Antineoplastic Agents KW - 0 KW - Culture Media KW - Folic Acid KW - 935E97BOY8 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Gene Expression Profiling KW - Dose-Response Relationship, Drug KW - Humans KW - DNA Methylation -- drug effects KW - Microarray Analysis KW - Cell Division -- drug effects KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Female KW - Culture Media -- chemistry KW - Folic Acid Deficiency KW - Lung Neoplasms -- drug therapy KW - Folic Acid -- pharmacology KW - Cisplatin -- pharmacology KW - Drug Resistance, Neoplasm KW - Antineoplastic Agents -- pharmacology KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68735604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+cancer&rft.atitle=Intrinsic+cisplatin+resistance+in+lung+and+ovarian+cancer+cells+propagating+in+medium+acutely+depleted+of+folate.&rft.au=Whiteside%2C+Martin+A%3BPiyathilake%2C+Chandrika+J%3BBushell%2C+Tamara+M%3BJohanning%2C+Gary+L&rft.aulast=Whiteside&rft.aufirst=Martin&rft.date=2006-01-01&rft.volume=54&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+cancer&rft.issn=01635581&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TOXMAP: a GIS-based gateway to environmental health resources. AN - 68732904; 16893844 AB - The National Library of Medicine (NLM) has an extensive collection of environmental health information, including bibliographic and technical data on hazardous chemical substances, in its TOXNET databases. TOXNET also provides access to the United States Environment Protection Agency (EPA)'s Toxics Release Inventory (TRI) data, which covers release of specific chemicals via air, water, and land, and by underground injection, as reported by industrial facilities around the United States. NLM has developed a Web-based geographic information system (GIS), TOXMAP , which allows users to create dynamic maps that show where TRI chemicals are released and that provides direct links to information about the chemicals in TOXNET. By extracting the associated regional geographic text terms from the displayed map (e.g., rivers, towns, county, state), TOXMAP also provides customized chemical and/or region-specific searches of NLM's bibliographic biomedical resources. This paper focuses on TOXMAP's features, data accuracy issues, challenges, user feedback techniques, and future directions. JF - Medical reference services quarterly AU - Hochstein, Colette AU - Szczur, Marti AD - Division of Specialized Information Services, National Library of Medicine, Bethesda, MD 20892, USA. colette@nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 13 EP - 31 VL - 25 IS - 3 SN - 0276-3869, 0276-3869 KW - Hazardous Substances KW - 0 KW - Health administration KW - United States KW - National Library of Medicine (U.S.) KW - Environmental Health KW - Databases, Factual KW - Geographic Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68732904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=TOXMAP%3A+a+GIS-based+gateway+to+environmental+health+resources.&rft.au=Hochstein%2C+Colette%3BSzczur%2C+Marti&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2006-01-01&rft.volume=25&rft.issue=3&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Regul Anal Med Waste. 1993 Mar;1(6):14-5 [10132830] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site. AN - 68645603; 16844666 AB - Adenoviral vectors have been shown to efficiently deliver exogenous genes to salivary glands and have therefore been investigated as tools for the treatment of human disease. The purpose of this study was to evaluate the response of F344 rats to intraductal infusion of the right submandibular salivary gland with an adenoviral vector encoding the gene for human growth hormone (AdCMVhGH). Co-administration of hydroxychloroquine (HCQ) was used to redirect the secretion of human growth hormone (hGH) from saliva into serum. This paper documents the findings of the pathology evaluation of this National Toxicology Program study. The right submandibular salivary gland (infusion site) was the primary target organ, with microscopic lesions characteristic of a mild to moderate insult observed at 3 days post infusion in vector exposed animals. These lesions were characterized by variable degrees of acute glandular inflammation, degeneration and necrosis, with more severe lesions in the higher dose groups. Rats at 28 days post infusion had milder inflammation, degeneration and necrosis compared to day 3 rats, with variable degrees of regeneration. In conclusion, the effects on the salivary glands are reversible as indicated by the milder inflammation and degeneration in the day 28 rats concomitant with mild to moderate regeneration. Therefore, the vector appears relatively innocuous with limited tissue toxicity. [The supplemental data referenced in this paper is not printed in this issue of Toxicologic Pathology. It is available as a downloadable file in the online edition of Toxicologic Pathology, 34(4). In order to access the full article online, you must have either an individual subscription or a member subscription accessed through www.toxpath.org.]. JF - Toxicologic pathology AU - Elmore, S AU - Lanning, L AU - Allison, N AU - Vallant, M AU - Nyska, A AD - Otsuka Maryland Research Institute, Rockville, Maryland, 20850, USA. elmore@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 385 EP - 392 VL - 34 IS - 4 SN - 0192-6233, 0192-6233 KW - Antirheumatic Agents KW - 0 KW - Human Growth Hormone KW - 12629-01-5 KW - Hydroxychloroquine KW - 4QWG6N8QKH KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Random Allocation KW - Fibrosis -- chemically induced KW - Humans KW - Inflammation -- chemically induced KW - Necrosis -- pathology KW - Antirheumatic Agents -- pharmacology KW - Submandibular Gland Diseases -- chemically induced KW - Adenoviridae -- genetics KW - Rats KW - Rats, Inbred F344 KW - Fibrosis -- pathology KW - Submandibular Gland Diseases -- epidemiology KW - Necrosis -- chemically induced KW - Antirheumatic Agents -- administration & dosage KW - Hydroxychloroquine -- pharmacology KW - Hydroxychloroquine -- administration & dosage KW - Incidence KW - Time Factors KW - Male KW - Female KW - Submandibular Gland Diseases -- pathology KW - Inflammation -- pathology KW - Gene Transfer Techniques KW - Submandibular Gland -- metabolism KW - Human Growth Hormone -- genetics KW - Genetic Vectors KW - Transduction, Genetic KW - Submandibular Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68645603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=The+transduction+of+rat+submandibular+glands+by+an+adenoviral+vector+carrying+the+human+growth+hormone+gene+is+associated+with+limited+and+reversible+changes+at+the+infusion+site.&rft.au=Elmore%2C+S%3BLanning%2C+L%3BAllison%2C+N%3BVallant%2C+M%3BNyska%2C+A&rft.aulast=Elmore&rft.aufirst=S&rft.date=2006-01-01&rft.volume=34&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats. AN - 68645568; 16844662 AB - Gene transcript changes after exposure to the heart toxin, bis(2-chloroethoxy)methane (CEM), were analyzed to elucidate mechanisms in cardiotoxicity and recovery. CEM was administered to 5-week-old male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure, 5 days per week, for a total of 12 doses by study day 16. Heart toxicity occurred after 2 days of dosing in all 3 regions of the heart (atrium, ventricle, interventricular septum) and was characterized by myofiber vacuolation, necrosis, mononuclear-cell infiltration, and atrial thrombosis. Ultrastructural analysis revealed that the primary site of damage was the mitochondrion. By day 5, even though dosing was continued, the toxic lesions in the heart began to resolve, and by study day 16, the heart appeared histologically normal. RNA was extracted from whole hearts after 2 or 5 days of CEM dosing. After a screen for transcript change by microarray analysis, dose-response trends for selected transcripts were analyzed by qRT-PCR. The selected transcripts code for proteins involved in energy production, control of calcium levels, and maintenance of heart function. The down-regulation of ATP subunit transcripts (Atp5j, ATP5k), which reside in the mitochondrial membranes, indicated a decrease in energy supply at day 2 and day 5. This was accompanied by down-regulation of transcripts involved in high-energy consumption processes such as membrane transport and ion channel transcripts (e.g., abc1a, kcnj12). The up-regulation of transcripts encoding for temperature regulation and calcium binding proteins (ucp1 and calb3) only at the 2 low exposure levels, suggest that these adaptive processes cannot occur in association with severe cardiotoxicity as seen in hearts at the high exposure level. Transcript expression changes occurred within 2 days of CEM exposure, and were dose-and time-dependent. The heart transcript changes suggest that CEM cardiotoxicity activates protective processes associated energy conservation and maintenance of heart function. JF - Toxicologic pathology AU - Dunnick, J AU - Blackshear, P AU - Kissling, G AU - Cunningham, M AU - Parker, J AU - Nyska, A AD - National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. dunnickj@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 348 EP - 356 VL - 34 IS - 4 SN - 0192-6233, 0192-6233 KW - Ethyl Ethers KW - 0 KW - bis(2-chloroethoxy)methane KW - Index Medicus KW - Molecular Structure KW - Animals KW - Drug Administration Schedule KW - Oligonucleotide Array Sequence Analysis KW - Dose-Response Relationship, Drug KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mitochondria, Heart -- ultrastructure KW - Mitochondria, Heart -- pathology KW - Molecular Weight KW - Rats KW - Rats, Inbred F344 KW - Mitochondria, Heart -- drug effects KW - Time Factors KW - Male KW - Ethyl Ethers -- chemistry KW - Transcription, Genetic -- drug effects KW - Myocardium -- pathology KW - Myocardium -- ultrastructure KW - Gene Expression Regulation -- drug effects KW - Myocardium -- metabolism KW - Ethyl Ethers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68645568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Critical+pathways+in+heart+function%3A+bis%282-chloroethoxy%29methane-induced+heart+gene+transcript+change+in+F344+rats.&rft.au=Dunnick%2C+J%3BBlackshear%2C+P%3BKissling%2C+G%3BCunningham%2C+M%3BParker%2C+J%3BNyska%2C+A&rft.aulast=Dunnick&rft.aufirst=J&rft.date=2006-01-01&rft.volume=34&rft.issue=4&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic. AN - 68632090; 16842197 AB - Angiogenesis is important in the growth and progression of solid tumours. The main pro-angiogenic factor, namely vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is a potent angiogenic cytokine that induces mitosis and also regulates the permeability of endothelial cells. The soluble isoform of VEGF is a dimeric glycoprotein of 36-46 kDa, induced by hypoxia and oncogenic mutation and it binds to two specific tyrosine-kinase receptors: VEGF-1 (flt-1) and VEGF-2 (KDR/flk1). An increase in VEGF expression in tumour tissue or some blood compartments (i.e. serum or plasma) has been found in solid and haematological malignancies of various origins and is associated with metastasis formation and poor prognosis. Bevacizumab, a recombinant humanised monoclonal antibody developed against VEGF, binds to soluble VEGF, preventing receptor binding and inhibiting endothelial cell proliferation and vessel formation. Pre-clinical and clinical studies have shown that bevacizumab alone or in combination with a cytotoxic agent decreases tumour growth and increases median survival time and time to tumour progression. Bevacizumab is the first anti-angiogenetic treatment approved by the American Food and Drug Administration in the first-line treatment of metastatic colorectal cancer. It has shown preliminary evidence of efficacy for breast, non-small-cell lung, pancreatic, prostate, head and neck and renal cancer as well as haematological malignancies. Common toxicities associated with bevacizumab include hypertension, proteinuria, bleeding episodes and thrombotic events. This review summarises the critical role of VEGF and discusses the data available on bevacizumab, from the humanisation of its parent murine monoclonal antibody (mAb) A.4.6.1 to its use in cancer clinical trials. JF - Current medicinal chemistry AU - Ranieri, Girolamo AU - Patruno, Rosa AU - Ruggieri, Eustachio AU - Montemurro, Severino AU - Valerio, Paolo AU - Ribatti, Domenico AD - Department of Clinical and Experimental Oncology, National Cancer Institute of Bari, Bari, Italy. giroran@tiscalinet.it Y1 - 2006 PY - 2006 DA - 2006 SP - 1845 EP - 1857 VL - 13 IS - 16 SN - 0929-8673, 0929-8673 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Vascular Endothelial Growth Factors KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Neovascularization, Pathologic -- drug therapy KW - Neoplasm Metastasis -- drug therapy KW - Humans KW - Molecular Sequence Data KW - Clinical Trials as Topic KW - Neoplasm Metastasis -- pathology KW - Amino Acid Sequence KW - Drug Evaluation, Preclinical KW - Neovascularization, Pathologic -- pathology KW - Angiogenesis Inhibitors -- therapeutic use KW - Neoplasms -- drug therapy KW - Angiogenesis Inhibitors -- pharmacology KW - Neoplasms -- pathology KW - Neoplasms -- blood supply KW - Antibodies, Monoclonal -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Vascular Endothelial Growth Factors -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68632090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medicinal+chemistry&rft.atitle=Vascular+endothelial+growth+factor+%28VEGF%29+as+a+target+of+bevacizumab+in+cancer%3A+from+the+biology+to+the+clinic.&rft.au=Ranieri%2C+Girolamo%3BPatruno%2C+Rosa%3BRuggieri%2C+Eustachio%3BMontemurro%2C+Severino%3BValerio%2C+Paolo%3BRibatti%2C+Domenico&rft.aulast=Ranieri&rft.aufirst=Girolamo&rft.date=2006-01-01&rft.volume=13&rft.issue=16&rft.spage=1845&rft.isbn=&rft.btitle=&rft.title=Current+medicinal+chemistry&rft.issn=09298673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-25 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Agonists and antagonists for P2 receptors. AN - 68592705; 16805423 AB - Recent work has identified nucleotide agonists selective for P2Y1, P2Y2 and P2Y6 receptors and nucleotide antagonists selective for P2Y1, P2Y12 and P2X1 receptors. Selective non-nucleotide antagonists have been reported for P2Y1, P2Y2, P2Y6, P2Y12, P2Y13, P2X(2/3)/P2X3 and P2X7 receptors. For example, the dinucleotide INS 37217 (Up4dC) potently activates the P2Y2 receptor, and the non-nucleotide antagonist A-317491 is selective for P2X(2/3)/P2X3 receptors. Nucleotide analogues in which the ribose moiety is substituted by a variety of novel ring systems, including conformationally locked moieties, have been synthesized as ligands for P2Y receptors. The focus on conformational factors of the ribose-like moiety allows the inclusion of general modifications that lead to enhanced potency and selectivity. At P2Y1,2,4,11 receptors, there is a preference for the North conformation as indicated with (N)-methanocarba analogues. The P2Y1 antagonist MRS2500 inhibited ADP-induced human platelet aggregation with an IC50 of 0.95 nM. MRS2365, an (N)-methanocarba analogue of 2-MeSADP, displayed potency (EC50) of 0.4nM at the P2Y1 receptor, with >10000-fold selectivity in comparison to P2Y12 and P2Y13 receptors. At P2Y6 receptors there is a dramatic preference for the South conformation. Three-dimensional structures of P2Y receptors have been deduced from structure activity relationships (SAR), mutagenesis and modelling studies. Detailed three-dimensional structures of P2X receptors have not yet been proposed. JF - Novartis Foundation symposium AU - Jacobson, Kenneth A AU - Costanzi, Stefano AU - Joshi, Bhalchandra V AU - Besada, Pedro AU - Shin, Dae Hong AU - Ko, Hyojin AU - Ivanov, Andrei A AU - Mamedova, Liaman AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 58 EP - 68; discussion 68-72, 107-12, 275-81 VL - 276 SN - 1528-2511, 1528-2511 KW - Ligands KW - 0 KW - Nucleotides KW - Purinergic P2 Receptor Agonists KW - Purinergic P2 Receptor Antagonists KW - Receptors, Purinergic P2 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Models, Molecular KW - Receptors, Purinergic P2 -- metabolism KW - Humans KW - Protein Conformation KW - Nucleotides -- metabolism KW - Nucleotides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Economic+History&rft.atitle=Patronage+Politics+and+the+Development+of+the+Welfare+State%3A+Confederate+Pensions+in+the+American+South&rft.au=Eli%2C+Shari%3BSalisbury%2C+Laura&rft.aulast=Eli&rft.aufirst=Shari&rft.date=2016-12-01&rft.volume=76&rft.issue=4&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Economic+History&rft.issn=00220507&rft_id=info:doi/10.1017%2FS0022050716000966 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - National Institute on Alcohol Abuse and Alcoholism and the study of fetal alcohol spectrum disorders. The International Consortium. AN - 68572119; 16801719 AB - Fetal alcohol syndrome (FAS) is a large and rapidly increasing public health problem worldwide. Aside the full-blown FAS, multiple terms are used to describe the continuum of effects that result from prenatal exposure to alcohol, including the whole fetal alcohol spectrum disorders (FASD). The revised Institute of Medicine (IOM) Diagnostic Classification System and the diagnostic criteria for FAS and FASD are reported, as well as the formation of the four-state FAS International Consortium and its aims, as the development of an information base that systematizes data collection that helps to determine at-high-risk populations, and to implement and test a scientific-based prevention/intervention model for at risk women. The Consortium was further enlarged, with the inclusion of some more states (including Italy), leading to the formation of the International Consortium for the Investigation of FASD. The objectives of the Consortium are reported, as well as its previous activities, the South Africa and Italy Projects (active case ascertainment initiatives), and its future activities. JF - Annali dell'Istituto superiore di sanita AU - Calhoun, Faye AU - Attilia, Maria Luisa AU - Spagnolo, Primavera Alessandra AU - Rotondo, Claudia AU - Mancinelli, Rosanna AU - Ceccanti, Mauro AD - National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 4 EP - 7 VL - 42 IS - 1 SN - 0021-2571, 0021-2571 KW - Index Medicus KW - United States KW - International Cooperation KW - Humans KW - National Institutes of Health (U.S.) KW - Adult KW - Female KW - Pregnancy KW - Fetal Alcohol Spectrum Disorders -- prevention & control KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Economic+History&rft.atitle=How+Technologically+Progressive+Was+Germany+in+the+Interwar+Period%3F+Evidence+on+Total+Factor+Productivity+in+Coal+Mining&rft.au=Jopp%2C+Tobias+A&rft.aulast=Jopp&rft.aufirst=Tobias&rft.date=2016-12-01&rft.volume=76&rft.issue=4&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Economic+History&rft.issn=00220507&rft_id=info:doi/10.1017%2FS0022050716001005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast. AN - 68565298; 16793410 AB - In vivo genome manipulation through site-directed mutagenesis and chromosome rearrangements has been hindered by the difficulty in achieving high frequencies of targeting and the intensive labor required to create altered genomes that do not contain any heterologous sequence. Here we describe our approach, referred to as delitto perfetto, that combines the versatility of synthetic oligonucleotides for targeting with the practicality of a general selection system. It provides for an enormously wide variety of genome modifications via homologous recombination. Exceptional high frequencies of mutations are reached when a site-specific double-strand break (DSB) is induced within the locus targeted by the synthetic oligonucleotides. Presented in this chapter is an in-depth description of a series of applications of the delitto perfetto strategy for mutagenesis and chromosome modification both with and without the induction of a DSB, along with the procedures and materials. JF - Methods in enzymology AU - Storici, Francesca AU - Resnick, Michael A AD - Laboratory of Molecular Genetics, Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 329 EP - 345 VL - 409 SN - 0076-6879, 0076-6879 KW - DNA Primers KW - 0 KW - Oligonucleotides KW - Index Medicus KW - Polymerase Chain Reaction KW - Base Sequence KW - Saccharomyces cerevisiae -- genetics KW - Mutagenesis, Site-Directed KW - Oligonucleotides -- genetics KW - Chromosomes, Fungal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68565298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+enzymology&rft.atitle=The+delitto+perfetto+approach+to+in+vivo+site-directed+mutagenesis+and+chromosome+rearrangements+with+synthetic+oligonucleotides+in+yeast.&rft.au=Storici%2C+Francesca%3BResnick%2C+Michael+A&rft.aulast=Storici&rft.aufirst=Francesca&rft.date=2006-01-01&rft.volume=409&rft.issue=&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Methods+in+enzymology&rft.issn=00766879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Environmental epigenomics, imprinting and disease susceptibility. AN - 68394790; 17998808 JF - Epigenetics AU - Heindel, Jerrold J AU - McAllister, Kimberly A AU - Worth, Leroy AU - Tyson, Frederick L Y1 - 2006 PY - 2006 DA - 2006 SP - 1 EP - 6 VL - 1 IS - 1 KW - Index Medicus KW - Fetus KW - Animals KW - Humans KW - Male KW - Female KW - Pregnancy KW - Genomic Imprinting KW - Epigenesis, Genetic -- genetics KW - Genetic Predisposition to Disease -- genetics KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68394790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Economic+History&rft.atitle=Growth+under+Extractive+Institutions%3F+Latin+American+Per+Capita+GDP+in+Colonial+Times&rft.au=Abad%2C+Leticia+Arroyo%3Bvan+Zanden%2C+Jan+Luiten&rft.aulast=Abad&rft.aufirst=Leticia&rft.date=2016-12-01&rft.volume=76&rft.issue=4&rft.spage=1182&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Economic+History&rft.issn=00220507&rft_id=info:doi/10.1017%2FS0022050716000954 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiation and high-LET-like 125IUdR exposures. AN - 68350502; 17145729 AB - Functional genomics studies were carried out to characterize the transcriptional response of normal human fibroblasts to ionizing radiation (IR) of different types. To this end, lung fibroblast IMR-90 cultures were exposed either to external beam gamma-radiation or to internal irradiation from decay of (125)I-labeled deoxyuridine ((125)IUdR) incorporated into the cellular DNA. A relatively small dose of 1 Gy of gamma-radiation was delivered to cell cultures either at a high dose-rate (HDR, 1 Gy, 1 min) or at a low dose-rate (LDR, 1 Gy, 22 h). More than 41,000 transcripts were assayed by oligo DNA microarray featuring all known and predicted genes in human genome. Gene expression profiles following gamma-radiation and decays of high-linear energy transfer (LET)-like (125)I share the majority of genes in common, indicating the involvement of similar pathways in signal transduction after IR exposures of different modalities. Gene Ontology (GO) analysis revealed that the oxidative phosphorylation, metabolism of nt, protein kinase cascade and cell cycle are among the up-regulated biological processes mostly affected by gamma-radiation in IMR-90 cells. The translational elongation, negative regulation of cell growth, antigen processing and protein targeting are down-regulated following IR exposures. About one-third of genes differentially expressed following either HDR or LDR gamma-radiation exposures in the same absorbed dose were different, indicating the involvement of distinct transcriptional programs in cellular response to irradiation delivered with the different dose rates. JF - Radiation protection dosimetry AU - Sokolov, M AU - Panyutin, I G AU - Neumann, R AD - Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1180, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 195 EP - 201 VL - 122 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Proteome KW - 0 KW - Idoxuridine KW - LGP81V5245 KW - Index Medicus KW - Radiation Dosage KW - Gene Expression Profiling KW - Gamma Rays KW - Linear Energy Transfer -- radiation effects KW - Humans KW - Linear Energy Transfer -- physiology KW - Dose-Response Relationship, Radiation KW - Chromosome Mapping -- methods KW - Cell Line KW - Gene Expression Regulation -- radiation effects KW - Proteome -- metabolism KW - Fibroblasts -- radiation effects KW - Fibroblasts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68350502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Economic+History&rft.atitle=Colonial+New+Jersey+Paper+Money%2C+1709-1775%3A+Value+Decomposition+and+Performance&rft.au=Grubb%2C+Farley&rft.aulast=Grubb&rft.aufirst=Farley&rft.date=2016-12-01&rft.volume=76&rft.issue=4&rft.spage=1216&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Economic+History&rft.issn=00220507&rft_id=info:doi/10.1017%2FS0022050716001029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A novel case of bisphosphonate-related osteonecrosis of the torus palatinus in a patient with metastatic breast cancer. AN - 68350406; 17657174 AB - Bisphosphonates administered orally and intravenously are used for a variety of endocrine and oncologic indications. Long-term intravenous use of bisphosphonates has been shown to cause osteonecrosis of the jaw. We report a case in which a 58-year-old woman with metastatic breast cancer received 18 doses of 4 mg intravenous zoledronic acid over a period of 16 months and developed a region of osteonecrosis on the posterior edge of a large, lobular torus palatinus. Torus palatinus, a type of maxillary exostosis, is common among postmenopausal women, and is vulnerable to blunt trauma that could predispose to osteonecrosis. Sequestrum of dead bone was removed and the site healed within 4 weeks. This case demonstrates that patients with a torus palatinus may be at high risk for osteonecrosis, and reinforces the need for good oral hygiene and frequent dental examination while receiving bisphosphonate therapy. JF - Oncology AU - Goldman, Matthew L AU - Denduluri, Neelima AU - Berman, Arlene W AU - Sausville, Rebecca AU - Guadagnini, Jean-Pierre AU - Kleiner, David E AU - Brahim, Jaime S AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 20889, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 306 EP - 308 VL - 71 IS - 3-4 KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Palate, Hard KW - Maxilla KW - Humans KW - Middle Aged KW - Female KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Breast Neoplasms -- pathology KW - Exostoses -- complications KW - Bone Density Conservation Agents -- therapeutic use KW - Bone Neoplasms -- drug therapy KW - Imidazoles -- therapeutic use KW - Osteonecrosis -- etiology KW - Imidazoles -- adverse effects KW - Bone Neoplasms -- secondary KW - Bone Density Conservation Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68350406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology&rft.atitle=A+novel+case+of+bisphosphonate-related+osteonecrosis+of+the+torus+palatinus+in+a+patient+with+metastatic+breast+cancer.&rft.au=Goldman%2C+Matthew+L%3BDenduluri%2C+Neelima%3BBerman%2C+Arlene+W%3BSausville%2C+Rebecca%3BGuadagnini%2C+Jean-Pierre%3BKleiner%2C+David+E%3BBrahim%2C+Jaime+S%3BSwain%2C+Sandra+M&rft.aulast=Goldman&rft.aufirst=Matthew&rft.date=2006-01-01&rft.volume=71&rft.issue=3-4&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Oncology&rft.issn=1423-0232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-29 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68326090; 17373404 AB - The 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) sought to determine the prevalence of drinking, smoking, and associated disorders in the general population. This survey, which includes a large representative sample of the adult population of the United States, found that drinking rates were highest among young adults and declined with increasing age. Rates of smoking and co-use of alcohol and tobacco were highest among the youngest respondents and declined thereafter. Similar patterns existed for the presence of alcohol use disorders (AUDs), nicotine dependence, and comorbidity between AUDs and nicotine dependence. Among ethnic/racial groups evaluated, Whites were most likely to drink and Native Americans/Alaskan Natives were most likely to smoke and to have an AUD, nicotine dependence, or comorbid AUD and nicotine dependence. Finally, the rates of tobacco use, daily tobacco use, and nicotine dependence increased with increasing levels of alcohol consumption and the presence of an AUD. These findings have important implications for the development of prevention and intervention approaches. JF - Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism AU - Falk, Daniel E AU - Yi, Hsiao-ye AU - Hiller-Sturmhöfel, Susanne AD - Alcohol Epidemiologic Data System of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), CSR Incorporated, Arlington, Virginia, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 162 EP - 171 VL - 29 IS - 3 SN - 1535-7414, 1535-7414 KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - Age Factors KW - Sex Factors KW - Humans KW - Health Surveys KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Ethnic Groups -- statistics & numerical data KW - Comorbidity KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- ethnology KW - Alcohol-Related Disorders -- ethnology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68326090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Economic+History&rft.atitle=Book+Reviews+%3A+The+First+Century+of+Welfare%3A+Poverty+and+Poor+Relief+in+Lancashire%2C+1620-1730&rft.au=Ottaway%2C+Susannah&rft.aulast=Ottaway&rft.aufirst=Susannah&rft.date=2016-12-01&rft.volume=11&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Neuropsychiatric+Disease+and+Treatment&rft.issn=11766328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell culture and infection system for hepatitis C virus. AN - 68325350; 17406476 AB - Hepatitis C virus (HCV) infection causes chronic liver disease and is a worldwide health problem. Despite ever-increasing demand for knowledge on viral replication and pathogenesis, detailed analysis has been hampered by a lack of efficient viral culture systems. We isolated HCV genotype 2a strain JFH-1 from a patient with fulminant hepatitis. This strain replicates efficiently in Huh7 cells. Efficient replication and secretion of recombinant viral particles can be obtained in cell culture by transfection of in vitro-transcribed full-length JFH-1 RNA into Huh7 cells. JFH-1 virus generated in cell culture is infectious for both naive Huh7 cells and chimpanzees. The efficiency of viral production and infectivity of generated virus is substantially improved with permissive cell lines. This protocol describes how to use this system, which provides a powerful tool for studying viral life cycle and for the construction of antiviral strategies and the development of effective vaccines. Viral particles can be obtained in 12 days with this protocol. JF - Nature protocols AU - Kato, Takanobu AU - Date, Tomoko AU - Murayama, Asako AU - Morikawa, Kenichi AU - Akazawa, Daisuke AU - Wakita, Takaji AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 2334 EP - 2339 VL - 1 IS - 5 KW - Hazardous Substances KW - 0 KW - RNA, Viral KW - Index Medicus KW - Animals KW - Hepatitis C -- virology KW - Electroporation KW - Humans KW - Adult KW - Male KW - Cell Line KW - Pan troglodytes KW - Hepacivirus -- physiology KW - Gene Transfer Techniques KW - Hepacivirus -- isolation & purification KW - Cell Culture Techniques -- methods KW - Virus Replication -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68325350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+protocols&rft.atitle=Cell+culture+and+infection+system+for+hepatitis+C+virus.&rft.au=Kato%2C+Takanobu%3BDate%2C+Tomoko%3BMurayama%2C+Asako%3BMorikawa%2C+Kenichi%3BAkazawa%2C+Daisuke%3BWakita%2C+Takaji&rft.aulast=Kato&rft.aufirst=Takanobu&rft.date=2006-01-01&rft.volume=1&rft.issue=5&rft.spage=2334&rft.isbn=&rft.btitle=&rft.title=Nature+protocols&rft.issn=1750-2799&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-23 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sildenafil in the treatment of pulmonary hypertension. AN - 68324600; 17323595 AB - The therapy of pulmonary hypertension has evolved rapidly in the last 10 years from the use of non-selective vasodilators to drugs that specifically target pulmonary vasodilation, endothelial function, and vascular remodeling. Sildenafil is a phosphodiesterase type 5 inhibitor that has an expanding role in the treatment of pulmonary hypertension. Case series and small studies, as well as the first large randomized controlled trial, have demonstrated the safety and efficacy of sildenafil in improving mean pulmonary artery pressure, pulmonary vascular resistance, cardiac index, and exercise tolerance in pulmonary arterial hypertension. It may be useful in adults, children, and neonates after cardiac surgery, with left heart failure, in fibrotic pulmonary disease, high altitude exposure, and thromboembolic disease, and in combination with other therapies for pulmonary hypertension, such as inhaled iloprost. The oral formulation and favorable adverse effect profile make sildenafil an attractive alternative in the treatment of selected patients with pulmonary hypertension. JF - Vascular health and risk management AU - Barnett, Christopher F AU - Machado, Roberto F AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 411 EP - 422 VL - 2 IS - 4 SN - 1176-6344, 1176-6344 KW - Antihypertensive Agents KW - 0 KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Sulfones KW - Vasodilator Agents KW - Sildenafil Citrate KW - BW9B0ZE037 KW - 3',5'-Cyclic-GMP Phosphodiesterases KW - EC 3.1.4.35 KW - Cyclic Nucleotide Phosphodiesterases, Type 5 KW - PDE5A protein, human KW - Index Medicus KW - Drug Therapy, Combination KW - Administration, Oral KW - Purines -- administration & dosage KW - Humans KW - Purines -- adverse effects KW - Pulmonary Artery -- physiopathology KW - 3',5'-Cyclic-GMP Phosphodiesterases -- antagonists & inhibitors KW - Treatment Outcome KW - Purines -- therapeutic use KW - Pulmonary Artery -- drug effects KW - Phosphodiesterase Inhibitors -- administration & dosage KW - Phosphodiesterase Inhibitors -- pharmacology KW - Piperazines -- therapeutic use KW - Hypertension, Pulmonary -- physiopathology KW - Vasodilator Agents -- administration & dosage KW - Vasodilator Agents -- therapeutic use KW - Piperazines -- adverse effects KW - Antihypertensive Agents -- pharmacology KW - Phosphodiesterase Inhibitors -- therapeutic use KW - Piperazines -- administration & dosage KW - Sulfones -- administration & dosage KW - Vasodilator Agents -- pharmacology KW - Hypertension, Pulmonary -- drug therapy KW - Sulfones -- adverse effects KW - Sulfones -- therapeutic use KW - Antihypertensive Agents -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Blood Pressure -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68324600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Childhood+predictors+of+adolescent+and+young+adult+outcome+in+ADHD&rft.au=Cheung%2C+Celeste+H.+M.%3BRijdijk%2C+Fruhling%3BMcLoughlin%2C+Gr%C3%A1inne%3BFaraone%2C+Stephen+V.%3BAsherson%2C+Philip%3BKuntsi%2C+Jonna&rft.aulast=Cheung&rft.aufirst=Celeste+H.&rft.date=2015-03-01&rft.volume=62&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2015.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-30 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2004 Jan 1;169(1):39-45 [12958054] Am J Respir Crit Care Med. 2004 Jan 1;169(1):34-8 [14525801] N Engl J Med. 2004 Feb 26;350(9):886-95 [14985486] J Am Coll Cardiol. 2004 Apr 7;43(7):1149-53 [15063421] J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):5S-12S [15194173] J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):40S-47S [15194177] J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):48S-55S [15194178] Liver Transpl. 2004 Jul;10(7):945-50 [15237383] Ann Intern Med. 2004 Aug 3;141(3):169-77 [15289213] Eur Respir J. 2004 Sep;24(3):339-40 [15358685] Circulation. 2004 Oct 12;110(15):2220-5 [15466636] Circulation. 1984 Oct;70(4):580-7 [6148159] Circulation. 1989 Nov;80(5):1198-206 [2805258] Biochem Biophys Res Commun. 1990 Aug 31;171(1):474-9 [1697465] J Heart Transplant. 1990 Sep-Oct;9(5):526-37 [2231091] Ann Intern Med. 1991 Sep 1;115(5):343-9 [1863023] Chest. 1991 Nov;100(5):1268-71 [1935280] J Am Coll Cardiol. 1992 Jan;19(1):48-54 [1729345] Adv Exp Med Biol. 1991;308:191-7 [1666264] Br J Anaesth. 2005 Oct;95(4):562 [16155044] Eur J Pediatr. 2005 Oct;164(10):626-9 [16012855] Hematol Oncol Clin North Am. 2005 Oct;19(5):881-96, vii [16214649] Chest. 2005 Oct;128(4):3065-73 [16236987] Arch Dis Child Fetal Neonatal Ed. 2005 Nov;90(6):F527-8 [16244212] Am J Cardiol. 2005 Nov 1;96(9):1334-6 [16253609] Eur Respir J. 2005 Nov;26(5):858-63 [16264047] N Engl J Med. 2005 Nov 17;353(20):2148-57 [16291984] Br J Ophthalmol. 2006 Feb;90(2):154-7 [16424524] Intensive Care Med. 2006 Mar;32(3):452-4 [16450094] J Paediatr Child Health. 2006 Mar;42(3):147-8 [16509918] N Engl J Med. 2006 Mar 9;354(10):1091-3; author reply 1091-3 [16525151] Eur Respir J. 2006 Sep;28(3):563-7 [16807265] J Am Coll Cardiol. 2000 Jan;35(1):176-82 [10636277] Cardiovasc Res. 1999 Aug 15;43(3):628-38 [10690334] Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):487-92 [10673190] Angiology. 2001 Jan;52(1):31-41 [11205929] Mol Pharmacol. 2001 May;59(5):1044-50 [11306686] AIDS. 2001 Sep 7;15(13):1747-8 [11546958] J Heart Lung Transplant. 2001 Sep;20(9):942-8 [11557188] Wilderness Environ Med. 2001 Fall;12(3):190-4 [11562018] Lancet. 2001 Oct 6;358(9288):1119-23 [11597664] Am J Respir Crit Care Med. 2001 Oct 1;164(7):1171-81 [11673205] N Engl J Med. 2002 Mar 21;346(12):896-903 [11907289] Ann Intern Med. 2002 Apr 2;136(7):515-22 [11926786] Biochem Pharmacol. 2002 May 1;63(9):1763-72 [12007579] Circulation. 2002 May 21;105(20):2398-403 [12021227] AIDS. 2002 Jul 26;16(11):1568-9 [12131202] BMJ. 2002 Jul 27;325(7357):181 [12142299] Am J Cardiol. 2002 Sep 15;90(6):677-80 [12231108] Circulation. 2002 Sep 17;106(12):1477-82 [12234951] Lancet. 2002 Sep 21;360(9337):895-900 [12354470] N Engl J Med. 1992 Jul 9;327(2):76-81 [1603139] Am J Physiol. 1994 May;266(5 Pt 1):L536-43 [7515580] Am J Cardiol. 1994 Sep 15;74(6):626-8 [8074054] N Engl J Med. 1996 Feb 1;334(5):296-301 [8532025] Am J Physiol. 1996 Mar;270(3 Pt 1):L362-7 [8638728] Br J Urol. 1996 Aug;78(2):257-61 [8813924] Circ Res. 1996 Oct;79(4):748-56 [8831498] Hematol Oncol Clin North Am. 1996 Dec;10(6):1289-303 [8956017] N Engl J Med. 1997 Jan 9;336(2):111-7 [8988890] Int J Impot Res. 1998 Jun;10(2):69-73; discussion 73-4 [9647940] Chest. 1998 Jul;114(1):334-6 [9674493] Chest. 1998 Sep;114(3 Suppl):184S-194S [9741567] J Biol Chem. 1998 Dec 18;273(51):34263-71 [9852090] Circulation. 2004 Nov 9;110(19):3149-55 [15533876] Am J Cardiol. 2004 Dec 1;94(11):1475-7 [15566933] Ann Thorac Surg. 2005 Jan;79(1):194-7; discussion 194-7 [15620942] Am J Respir Crit Care Med. 2005 Feb 1;171(3):275-81 [15516532] Basic Res Cardiol. 2005 Mar;100(2):131-8 [15739122] J Cardiovasc Pharmacol. 2005 Apr;45(4):286-9 [15772514] J Heart Lung Transplant. 2005 Apr;24(4):498-500 [15797756] Haematologica. 2005 Apr;90(4):452-8 [15820939] Transplant Proc. 2005 Apr;37(3):1550-1 [15866670] Br J Haematol. 2005 May;129(4):449-64 [15877728] Am J Respir Crit Care Med. 2005 Jun 1;171(11):1292-7 [15750042] Circulation. 2005 Jun 14;111(23):3105-11 [15939821] Circulation. 2005 Jun 21;111(24):3274-80 [15956137] Am J Respir Crit Care Med. 2005 Jul 1;172(1):105-13 [15817798] Br J Haematol. 2005 Aug;130(3):445-53 [16042696] Thorax. 2005 Aug;60(8):683-7 [16061711] Biol Neonate. 2005;88(2):109-12 [15870496] Semin Respir Crit Care Med. 2005 Aug;26(4):402-8 [16121317] Nat Med. 2002 Dec;8(12):1383-9 [12426562] Blood. 2003 Feb 15;101(4):1257-61 [12393669] Nutr Metab Cardiovasc Dis. 2002 Oct;12(5):306-10 [12616811] Am J Respir Crit Care Med. 2003 Apr 15;167(8):1139-41 [12684251] Indian Heart J. 2003 Jan-Feb;55(1):55-9 [12760589] Br J Pharmacol. 2003 Jun;139(3):513-22 [12788811] Lancet. 2003 Jun 7;361(9373):1967-74 [12801752] Circulation. 2003 Jul 1;107(25):3230-5 [12796132] J Am Coll Cardiol. 2003 Jul 2;42(1):158-64 [12849677] AIDS. 2003 Jul 25;17(11):1714-5 [12853763] Circulation. 2003 Sep 9;108 Suppl 1:II167-73 [12970227] Intensive Care Med. 2003 Nov;29(11):1996-2003 [14530859] Pediatr Pulmonol. 2003 Dec;36(6):529-35 [14618646] N Engl J Med. 2003 Nov 27;349(22):2099-107 [14645637] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis. AN - 68323176; 17406295 AB - Cytotoxic T lymphocytes, and other death-inducing agents, have at least two different ways of killing their targets: drilling holes in the target cell membrane, or triggering the targets to commit suicide. The JAM Test is a method that measures the DNA fragmentation that accompanies cell suicide. We label target cells with radioactive DNA-precursor nucleotides and harvest them onto fiberglass filters, which trap large pieces of DNA but pass smaller fragments of apoptotic cells. As a general measure of apoptosis, the JAM Test described here is faster (can be completed in 4 h [or less if labeling is done the night before]), more quantitative, easier, more sensitive, more flexible and cheaper than most other current assays of apoptosis. The P-JAM, also discussed, additionally allows for assessment of death in cells that don't fragment their DNA, and allows for assays of agents that induce cell stasis rather than death. JF - Nature protocols AU - Usharauli, David AU - Perez-Diez, Ainhoa AU - Matzinger, Polly AD - Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, Maryland 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 672 EP - 682 VL - 1 IS - 2 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Spleen -- cytology KW - Cell Death KW - Mice KW - Cytotoxicity Tests, Immunologic -- methods KW - T-Lymphocytes, Cytotoxic -- immunology KW - DNA Fragmentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68323176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+protocols&rft.atitle=The+JAM+Test+and+its+daughter+P-JAM%3A+simple+tests+of+DNA+fragmentation+to+measure+cell+death+and+stasis.&rft.au=Usharauli%2C+David%3BPerez-Diez%2C+Ainhoa%3BMatzinger%2C+Polly&rft.aulast=Usharauli&rft.aufirst=David&rft.date=2006-01-01&rft.volume=1&rft.issue=2&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Nature+protocols&rft.issn=1750-2799&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-21 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The physiology and evolution of urea transport in fishes. AN - 68315734; 17264987 AB - This review summarizes what is currently known about urea transporters in fishes in the context of their physiology and evolution within the vertebrates. The existence of urea transporters has been investigated in red blood cells and hepatocytes of fish as well as in renal and branchial cells. Little is known about urea transport in red blood cells and hepatocytes, in fact, urea transporters are not believed to be present in the erythrocytes of elasmobranchs nor in teleost fish. What little physiological evidence there is for urea transport across fish hepatocytes is not supported by molecular evidence and could be explained by other transporters. In contrast, early findings on elasmobranch renal urea transporters were the impetus for research in other organisms. Urea transport in both the elasmobranch kidney and gill functions to retain urea within the animal against a massive concentration gradient with the environment. Information on branchial and renal urea transporters in teleost fish is recent in comparison but in teleosts urea transporters appear to function for excretion and not retention as in elasmobranchs. The presence of urea transporters in fish that produce a copious amount of urea, such as elasmobranchs and ureotelic teleosts, is reasonable. However, the existence of urea transporters in ammoniotelic fish is curious and could likely be due to their ability to manufacture urea early in life as a means to avoid ammonia toxicity. It is believed that the facilitated diffusion urea transporter (UT) gene family has undergone major evolutionary changes, likely in association with the role of urea transport in the evolution of terrestriality in the vertebrates. JF - The Journal of membrane biology AU - McDonald, M D AU - Smith, C P AU - Walsh, P J AD - NIEHS Marine and Freshwater Biomedical Sciences Center, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, Florida 33149-1098, USA. dmcdonald@rsmas.miami.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 93 EP - 107 VL - 212 IS - 2 SN - 0022-2631, 0022-2631 KW - Membrane Transport Proteins KW - 0 KW - urea transporter KW - Urea KW - 8W8T17847W KW - Index Medicus KW - Animals KW - Biological Transport, Active -- physiology KW - Urea -- metabolism KW - Biological Evolution KW - Kidney -- physiology KW - Membrane Transport Proteins -- physiology KW - Fishes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68315734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+membrane+biology&rft.atitle=The+physiology+and+evolution+of+urea+transport+in+fishes.&rft.au=McDonald%2C+M+D%3BSmith%2C+C+P%3BWalsh%2C+P+J&rft.aulast=McDonald&rft.aufirst=M&rft.date=2006-01-01&rft.volume=212&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+membrane+biology&rft.issn=00222631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - NTP workshop: animal models for the NTP rodent cancer bioassay: stocks and strains--should we switch? AN - 68242622; 17162538 AB - The National Toxicology Program (NTP) hosted a workshop, "Animal Models for the NTP Rodent Cancer Bioassay: Strains and Stocks--Should We Switch?" on June 16-17, 2005, at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina. The workshop's objectives were to determine (1) whether the currently used models, the F344/N rat and B6C3F1/N mouse, continue to be appropriate to identify substances that may pose a carcinogenic hazard for humans and (2) whether the NTP should consider conducting cancer bioassays using multiple strains of rats and/or mice to better capture the range of genetic variability. Workshop participants advised the NTP to discontinue using the current F344/N strain due to the recent issues with fertility, seizure activity, and chylothorax and provided several options on how the program should approach identifying and selecting a new rat model. Participants believed that the B6C3F1/N mouse is still appropriate for use by the NTP, but suggested the NTP take steps to better understand and address increases in background rates of liver tumors in this strain. Finally, the participants supported the NTP exploring the use of the multiple strain approach, although they raised many questions concerning data interpretation and feasibility. This article also outlines the NTP's next steps in pursuing the workshop recommendations. JF - Toxicologic pathology AU - King-Herbert, Angela AU - Thayer, Kristina Y1 - 2006 PY - 2006 DA - 2006 SP - 802 EP - 805 VL - 34 IS - 6 KW - Carcinogens KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Humans KW - Mice KW - Guidelines as Topic KW - Species Specificity KW - Risk Assessment KW - Models, Animal KW - Carcinogenicity Tests -- trends KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68242622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Toxicologic+pathology&rft.atitle=NTP+workshop%3A+animal+models+for+the+NTP+rodent+cancer+bioassay%3A+stocks+and+strains--should+we+switch%3F&rft.au=King-Herbert%2C+Angela%3BThayer%2C+Kristina&rft.aulast=King-Herbert&rft.aufirst=Angela&rft.date=2006-01-01&rft.volume=34&rft.issue=6&rft.spage=802&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-19 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1969 Jun;42(6):1101-14 [5793189] Fundam Appl Toxicol. 1988 Apr;10(3):385-94 [3286346] Environ Health Perspect. 1995 Jan;103(1):44-52 [7628425] Lab Anim Sci. 1995 Dec;45(6):635-40 [8746522] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimal sampling of rat liver tissue for toxicogenomic studies. AN - 68240281; 17162537 AB - Different degrees of a toxic response between and within the various lobes of the liver have been observed in rodents following treatment with acetaminophen. This study was designed to compare 2 sampling methods of the rat liver for gene-expression analysis. Ten male Fischer 344/N rats, 12-14 weeks of age, were treated with vehicle (0.5% aqueous ethyl cellulose) or acetaminophen (APAP, 1500 mg/kg) and sacrificed 24 hours following dose administration. Two representative sections were collected from the left liver lobe, stained with hematoxylin and eosin (H&E), and evaluated independently by 2 pathologists. The central core of the left lobe was cubed and frozen. Five random cubes were conserved, while the remaining left lobe core was pulverized. From each of the 10 animals, 2 random cubes and 2 samples from the homogeneous, pulverized samples were prepared for microarray analysis. Histopathologic evaluation revealed a variable response of centrilobular necrosis within the left lobe. Multiple methods used to analyze the microarray data indicated that sampling technique was not a major contributor to the variability observed in the gene expression data; however, only the powdered samples clustered for all animals, even those with disparate histopathologic results. Additionally, a powdered sample provided the advantages of a homogenous sample pool and the ability to use sample aliquots for other analyses to include proteomics, metabonomics, and other molecular techniques. JF - Toxicologic pathology AU - Foley, Julie F AU - Collins, Jennifer B AU - Umbach, David M AU - Grissom, Sherry AU - Boorman, Gary A AU - Heinloth, Alexandra N AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. foley1@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 795 EP - 801 VL - 34 IS - 6 SN - 0192-6233, 0192-6233 KW - Analgesics, Non-Narcotic KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Oligonucleotide Array Sequence Analysis KW - Reproducibility of Results KW - Principal Component Analysis KW - Selection Bias KW - Rats KW - Gene Expression Profiling KW - Rats, Inbred F344 KW - Analgesics, Non-Narcotic -- toxicity KW - Gene Expression Regulation -- drug effects KW - Cluster Analysis KW - Male KW - Liver -- pathology KW - Liver -- drug effects KW - Toxicogenetics -- methods KW - Specimen Handling -- methods KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68240281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Optimal+sampling+of+rat+liver+tissue+for+toxicogenomic+studies.&rft.au=Foley%2C+Julie+F%3BCollins%2C+Jennifer+B%3BUmbach%2C+David+M%3BGrissom%2C+Sherry%3BBoorman%2C+Gary+A%3BHeinloth%2C+Alexandra+N&rft.aulast=Foley&rft.aufirst=Julie&rft.date=2006-01-01&rft.volume=34&rft.issue=6&rft.spage=795&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-19 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2001 Oct;63(2):245-55 [11568368] Nat Methods. 2005 May;2(5):351-6 [15846362] Toxicol Pathol. 2005;33(1):111-7 [15805062] Carcinogenesis. 1986 Feb;7(2):247-51 [2868806] Biochem Pharmacol. 1975 Jan 1;24(1):37-42 [1122260] J Biotechnol. 2005 Sep 29;119(3):219-44 [16005536] Toxicol Sci. 2005 Jul;86(1):185-93 [15814895] Mutat Res. 2005 Aug 4;575(1-2):102-15 [15924886] Toxicol Sci. 2005 Jun;85(2):1048-63 [15800033] Nat Genet. 2002 Dec;32 Suppl:474-9 [12454641] Environ Health Perspect. 2004 Mar;112(4):439-48 [15033593] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:72-83 [15209406] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice. AN - 68237236; 17162533 AB - Benzene and ethylene oxide are multisite carcinogens in rodents and classified as human carcinogens by the National Toxicology Program. In 2-year mouse studies, both chemicals induced mammary carcinomas. We examined spontaneous, benzene-, and ethylene oxide-induced mouse mammary carcinomas for p53 protein expression, using immunohistochemistry, and p53 (exons 5-8) and H-ras (codon 61) mutations using cycle sequencing techniques. p53 protein expression was detected in 42% (8/19) of spontaneous, 43% (6/14) of benzene-, and 67% (8/12) of ethylene oxide-induced carcinomas. However, semiquantitative evaluation of p53 protein expression revealed that benzene- and ethylene oxide-induced carcinomas exhibited expression levels five- to six-fold higher than spontaneous carcinomas. p53 mutations were found in 58% (7/12) of spontaneous, 57% (8/14) of benzene-, and 67% (8/12) of ethylene oxide-induced carcinomas. H-ras mutations were identified in 26% (5/19) of spontaneous, 50% (7/14) of benzene-, and 33% (4/12) of ethylene oxide-induced carcinomas. When H-ras mutations were present, concurrent p53 mutations were identified in 40% (2/5) of spontaneous, 71% (5/7) of benzene-, and 75% (3/4) of ethylene oxide-induced carcinomas. Our results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations. JF - Toxicologic pathology AU - Houle, Christopher D AU - Ton, Thai-Vu T AU - Clayton, Natasha AU - Huff, James AU - Hong, Hue-Hua L AU - Sills, Robert C AD - Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA. houle@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 752 EP - 762 VL - 34 IS - 6 SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - Codon KW - Tumor Suppressor Protein p53 KW - Benzene KW - J64922108F KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Exons KW - DNA Mutational Analysis KW - Mice KW - Immunohistochemistry KW - Female KW - Mammary Neoplasms, Animal -- pathology KW - Mammary Neoplasms, Animal -- genetics KW - Mammary Neoplasms, Experimental -- genetics KW - Mammary Neoplasms, Animal -- chemically induced KW - Mammary Neoplasms, Experimental -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Rodent Diseases -- pathology KW - Mammary Neoplasms, Experimental -- pathology KW - Gene Expression Regulation, Neoplastic KW - Genes, ras KW - Mammary Neoplasms, Experimental -- chemically induced KW - Rodent Diseases -- chemically induced KW - Rodent Diseases -- metabolism KW - Mammary Neoplasms, Animal -- metabolism KW - Tumor Suppressor Protein p53 -- genetics KW - Rodent Diseases -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68237236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Frequent+p53+and+H-ras+mutations+in+benzene-+and+ethylene+oxide-induced+mammary+gland+carcinomas+from+B6C3F1+mice.&rft.au=Houle%2C+Christopher+D%3BTon%2C+Thai-Vu+T%3BClayton%2C+Natasha%3BHuff%2C+James%3BHong%2C+Hue-Hua+L%3BSills%2C+Robert+C&rft.aulast=Houle&rft.aufirst=Christopher&rft.date=2006-01-01&rft.volume=34&rft.issue=6&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-19 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prenatal drug exposure effects on subsequent vulnerability to drug abuse. AN - 68223106; 17152406 AB - Research has shown that both prenatal alcohol and tobacco exposure are associated with increased risk of significant adverse medical, developmental, and behavioral outcomes including substance abuse. Research on the outcomes of prenatal exposure to illicit drugs (PNDE) has also found increased physical and behavioral problems for gestationally drug-exposed children. However, a clear picture has not emerged on whether the consequences of PNDE are independent from those associated with having a substance abusing parent and whether PNDE increases vulnerability to drug abuse. Because of its typical co-occurrence with factors inherent in having a drug-abusing parent, PNDE is at least a marker of significant increased risk for a range of negative outcomes including greater vulnerability to substance abuse. Although a review of the relevant research literatures indicates that the direct consequences of PNDE appear to be generally both subtle and nonglobal, PNDE does appear to have negative developmental and behavioral outcomes, and there is evidence that it is a modest direct contributor to increased substance abuse vulnerability. JF - Development and psychopathology AU - Glantz, Meyer D AU - Chambers, Jessica Campbell AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9589, USA. mglantz@nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 893 EP - 922 VL - 18 IS - 3 SN - 0954-5794, 0954-5794 KW - Street Drugs KW - 0 KW - Index Medicus KW - Life Style KW - Parenting KW - Humans KW - Prefrontal Cortex -- physiopathology KW - Parent-Child Relations KW - Child KW - Attitude KW - Female KW - Social Environment KW - Pregnancy KW - Social Behavior Disorders -- epidemiology KW - Child of Impaired Parents -- psychology KW - Child of Impaired Parents -- statistics & numerical data KW - Social Behavior Disorders -- physiopathology KW - Substance-Related Disorders -- epidemiology KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68223106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+and+psychopathology&rft.atitle=Prenatal+drug+exposure+effects+on+subsequent+vulnerability+to+drug+abuse.&rft.au=Glantz%2C+Meyer+D%3BChambers%2C+Jessica+Campbell&rft.aulast=Glantz&rft.aufirst=Meyer&rft.date=2006-01-01&rft.volume=18&rft.issue=3&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Development+and+psychopathology&rft.issn=09545794&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-10 N1 - Date created - 2006-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleophosmin and human cancer. AN - 68219022; 17113241 AB - Nucleophosmin (NPM) is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. NPM has several interacting partners and diverse cellular functions, including the processing of ribosomal RNA, centrosome duplication and the control of cellular processes to ensure genomic stability. Subcellular localization of NPM appears to be strongly correlated with NPM functions and cell proliferation. NPM is phosphorylated mainly at its central acidic domain by several upstream kinases, and its phosphorylation appears to be involved in regulating its functions in ribosome biogenesis and centrosome duplication. Recent studies suggest that NPM may act as a licensing factor to maintain proper centrosome duplication and that the Ran/CRM1 nucleocytoplasmic complex regulates local trafficking of NPM to centrosomes by interacting through its nuclear export sequence motif. Here, we provide a brief overview of NPM functions and its roles in human carcinogenesis, and discuss our recent findings related to the potential mechanisms underlying its regulation of centrosome duplication. JF - Cancer detection and prevention AU - Lim, Mi Jung AU - Wang, Xin Wei AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 481 EP - 490 VL - 30 IS - 6 SN - 0361-090X, 0361-090X KW - Nuclear Proteins KW - 0 KW - Phosphoproteins KW - nucleophosmin KW - 117896-08-9 KW - Index Medicus KW - Phosphorylation KW - Humans KW - Cell Transformation, Neoplastic -- metabolism KW - Cell Cycle -- physiology KW - Phosphoproteins -- genetics KW - Nuclear Proteins -- genetics KW - Centrosome -- physiology KW - Nuclear Proteins -- metabolism KW - Neoplasms -- etiology KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68219022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention&rft.atitle=Nucleophosmin+and+human+cancer.&rft.au=Lim%2C+Mi+Jung%3BWang%2C+Xin+Wei&rft.aulast=Lim&rft.aufirst=Mi&rft.date=2006-01-01&rft.volume=76&rft.issue=4&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Economic+History&rft.issn=00220507&rft_id=info:doi/10.1017%2FS0022050716001170 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1994 Mar 4;263(5151):1281-4 [8122112] Cell Mol Biol Res. 1993;39(7):635-45 [8054998] J Biol Chem. 1994 Sep 23;269(38):23776-83 [8089149] J Biol Chem. 1994 Dec 9;269(49):30994-8 [7527039] J Biol Chem. 1995 Apr 21;270(16):9429-36 [7721868] Biochim Biophys Acta. 1995 May 17;1262(1):37-42 [7772597] Biochemistry. 1995 Jun 27;34(25):8037-42 [7794916] Biochem Biophys Res Commun. 1995 Dec 5;217(1):313-25 [8526928] Blood. 1996 Feb 1;87(3):882-6 [8562957] Oncogene. 1996 Jan 18;12(2):265-75 [8570204] Biochemistry. 1996 Feb 27;35(8):2668-73 [8611572] Eur J Biochem. 1996 Apr 1;237(1):153-8 [8620867] Mol Biol Cell. 1997 Feb;8(2):231-48 [9190204] Biochemistry. 1997 Apr 1;36(13):3941-9 [9092824] J Virol. 1997 May;71(5):4098-102 [9094689] Nucleic Acids Res. 1998 Oct 1;26(19):4508-15 [9742256] Biochem Biophys Res Commun. 1999 Apr 21;257(3):865-70 [10208875] Protein Sci. 1999 Apr;8(4):905-12 [10211837] N Engl J Med. 2005 Jan 20;352(3):254-66 [15659725] Mol Cell Biol. 2005 Feb;25(4):1258-71 [15684379] Nat Cell Biol. 2005 Aug;7(8):823-30 [16041368] Blood. 2005 Aug 15;106(4):1419-22 [15870172] Nature. 2005 Sep 1;437(7055):147-53 [16007073] Mol Cell Biol. 2006 May;26(10):3798-809 [16648475] Blood. 2006 Jun 1;107(11):4514-23 [16455950] Nat Rev Cancer. 2006 Jul;6(7):493-505 [16794633] Nucleic Acids Res. 1995 Oct 11;23(19):3974-9 [7479045] Cancer Lett. 2000 May 29;153(1-2):151-60 [10779644] J Biol Chem. 2000 Aug 11;275(32):24451-7 [10829026] Curr Top Dev Biol. 2000;49:313-29 [11005025] Cell. 2000 Sep 29;103(1):127-40 [11051553] Mol Cell. 2001 Oct;8(4):841-53 [11684019] J Biol Chem. 2001 Dec 21;276(51):48285-91 [11604407] Carcinogenesis. 2002 Jan;23(1):93-100 [11756229] Mol Biol Cell. 2002 Jun;13(6):2016-30 [12058066] Nat Cell Biol. 2002 Jul;4(7):529-33 [12080348] Biosci Biotechnol Biochem. 2002 Oct;66(10):2239-42 [12450141] J Biol Chem. 2003 Mar 14;278(11):9107-15 [12511551] Mol Cell Biol. 2003 Aug;23(15):5282-92 [12861014] Mol Biol Cell. 2003 Oct;14(10):4260-71 [14517334] Mol Cell. 2003 Nov;12(5):1151-64 [14636574] Mol Cell Biol. 2004 Feb;24(3):985-96 [14729947] Cancer Cell. 2004 May;5(5):465-75 [15144954] J Biol Chem. 2004 Aug 20;279(34):35726-34 [15190079] J Biol Chem. 2004 Oct 1;279(40):41275-9 [15310764] Cell Cycle. 2004 Mar;3(3):259-62 [14726681] Cell Cycle. 2004 Mar;3(3):305-13 [14726649] Mol Cell Biol. 2004 Nov;24(21):9327-38 [15485902] Annu Rev Biochem. 1979;48:923-59 [38740] Biochim Biophys Acta. 1981 Jan 30;667(1):209-12 [7213797] Biochim Biophys Acta. 1985 Dec 18;826(4):167-73 [3907710] J Biol Chem. 1986 Feb 5;261(4):1868-72 [3944116] Biochim Biophys Acta. 1987 Jul 16;925(1):74-82 [3593769] J Biol Chem. 1987 Aug 15;262(23):11389-97 [3301855] EMBO J. 1987 Jul;6(7):1881-90 [3308448] J Biol Chem. 1988 Aug 5;263(22):10608-12 [3392030] J Cell Biol. 1988 Nov;107(5):1629-42 [3141428] Cell. 1989 Feb 10;56(3):379-90 [2914325] Biochemistry. 1989 Feb 7;28(3):1033-9 [2713355] Cell. 1990 Mar 9;60(5):791-801 [2178776] Biochem J. 1990 Sep 1;270(2):549-52 [2400401] J Biol Chem. 1990 Oct 25;265(30):18227-33 [2211699] Mol Cell Biol. 1991 May;11(5):2567-75 [2017166] Exp Cell Res. 1991 Jun;194(2):289-96 [2026181] Cell Mol Biol Res. 1993;39(1):33-42 [8287070] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oceans and human health: Emerging public health risks in the marine environment. AN - 68162155; 16996542 AB - There has been an increasing recognition of the inter-relationship between human health and the oceans. Traditionally, the focus of research and concern has been on the impact of human activities on the oceans, particularly through anthropogenic pollution and the exploitation of marine resources. More recently, there has been recognition of the potential direct impact of the oceans on human health, both detrimental and beneficial. Areas identified include: global change, harmful algal blooms (HABs), microbial and chemical contamination of marine waters and seafood, and marine models and natural products from the seas. It is hoped that through the recognition of the inter-dependence of the health of both humans and the oceans, efforts will be made to restore and preserve the oceans. JF - Marine pollution bulletin AU - Fleming, L E AU - Broad, K AU - Clement, A AU - Dewailly, E AU - Elmir, S AU - Knap, A AU - Pomponi, S A AU - Smith, S AU - Solo Gabriele, H AU - Walsh, P AD - National Science Foundation (NSF), National Institute of Environmental Health Sciences (NIEHS), Oceans and Human Health Center, University of Miami, Miami, FL, USA. lfleming@med.miami.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 545 EP - 560 VL - 53 IS - 10-12 SN - 0025-326X, 0025-326X KW - Biological Products KW - 0 KW - Index Medicus KW - Seafood -- poisoning KW - Oceans and Seas KW - Animals KW - Eutrophication KW - Risk Factors KW - Humans KW - Climate KW - Seafood -- microbiology KW - Water Microbiology KW - Seawater -- chemistry KW - Environment KW - Seawater -- microbiology KW - Public Health -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68162155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+pollution+bulletin&rft.atitle=Oceans+and+human+health%3A+Emerging+public+health+risks+in+the+marine+environment.&rft.au=Fleming%2C+L+E%3BBroad%2C+K%3BClement%2C+A%3BDewailly%2C+E%3BElmir%2C+S%3BKnap%2C+A%3BPomponi%2C+S+A%3BSmith%2C+S%3BSolo+Gabriele%2C+H%3BWalsh%2C+P&rft.aulast=Fleming&rft.aufirst=L&rft.date=2006-01-01&rft.volume=53&rft.issue=10-12&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Marine+pollution+bulletin&rft.issn=0025326X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Trop Med Int Health. 1997 Dec;2(12):1122-7 [9438466] Rev Sci Tech. 1997 Aug;16(2):620-40 [9501377] Rev Sci Tech. 1997 Aug;16(2):661-72 [9501380] Int J Epidemiol. 1998 Feb;27(1):1-9 [9563686] Nature. 1998 Jul 2;394(6688):28-9 [9665124] JAMA. 1998 Aug 26;280(8):701-7 [9728641] Int J Epidemiol. 1998 Aug;27(4):722-6 [9758131] Int J Occup Environ Health. 1998 Jan-Mar;4(1):41-52 [10036363] Epidemiology. 1999 Jul;10(4):355-63 [10401868] Appl Environ Microbiol. 1999 Sep;65(9):4118-25 [10473424] Am J Respir Crit Care Med. 2005 Jan 1;171(1):26-34 [15447946] Antonie Van Leeuwenhoek. 2005 Jan;87(1):43-8 [15726290] Environ Health Perspect. 2005 May;113(5):650-7 [15866779] Environ Health Perspect. 2002 Nov;110(11):A674-81 [12417494] Appl Environ Microbiol. 2000 Jan;66(1):230-7 [10618229] Environ Health Perspect. 2000 Mar;108 Suppl 1:133-41 [10698729] Environ Health Perspect. 2000 Mar;108(3):205-11 [10706525] Annu Rev Biochem. 1999;68:59-88 [10872444] Adv Parasitol. 2000;47:309-30 [10997211] Bull World Health Organ. 2000;78(9):1127-35 [11019461] Environ Res. 2000 Oct;84(2):145-50 [11068928] Int J Food Microbiol. 2000 Nov 1;61(2-3):91-125 [11078162] Nat Prod Rep. 2001 Feb;18(1):1-49 [11245399] J Epidemiol Community Health. 2001 Jun;55(6):442-7 [11351003] Curr Opin Microbiol. 2001 Jun;4(3):290-5 [11378481] Mar Pollut Bull. 2001 Apr;42(4):286-93 [11381749] Arch Environ Health. 2001 Jul-Aug;56(4):350-7 [11572279] Appl Environ Microbiol. 2002 Mar;68(3):1165-72 [11872464] Mar Environ Res. 2002 Jun;53(5):425-52 [12054104] Environ Health Perspect. 2002 Sep;110(9):839-45 [12204815] Nature. 2002 Sep 12;419(6903):215-23 [12226676] Rev Biol Trop. 2002 Jun;50(2):395-414 [12298274] Appl Environ Microbiol. 2002 Oct;68(10):5005-11 [12324350] Environ Health Perspect. 2002 Nov;110(11):A660-1 [12417490] Can J Public Health. 2002 Sep-Oct;93 Suppl 1:S34-8 [12425173] Parasitol Res. 2003 Jan;89(2):141-5 [12489014] Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7 [12548698] Environ Health Perspect. 2004 Jun;112(8):A455-6 [15175187] Emerg Infect Dis. 2004 May;10(5):802-9 [15200812] Curr Med Chem. 2004 Jul;11(13):1693-713 [15279577] J Nat Prod. 2004 Aug;67(8):1216-38 [15332835] Bioorg Med Chem. 2004 Sep 15;12(18):4929-36 [15336272] Am J Epidemiol. 1982 Mar;115(3):348-51 [6278928] J Pediatr. 1986 Aug;109(2):335-41 [3090217] Soc Sci Med. 1986;23(10):983-93 [3493537] Appl Environ Microbiol. 1988 Feb;54(2):513-7 [3281583] Appl Environ Microbiol. 1988 Apr;54(4):979-83 [3288121] Epidemiol Infect. 1989 Dec;103(3):603-11 [2558031] Am J Public Health. 1991 Oct;81(10):1268-72 [1928524] Arch Intern Med. 1992 Oct;152(10):2049-53 [1417378] Sci Total Environ. 1992;Suppl:631-62 [1475681] Clin Rev Allergy. 1993 Summer;11(2):241-60 [8221511] Epidemiol Infect. 1994 Feb;112(1):1-11 [8119348] Sci Am. 1994 Aug;271(2):62-8 [8066432] Rev Environ Contam Toxicol. 1994;138:1-20 [7938783] J Appl Bacteriol. 1994 Sep;77(3):281-7 [7989253] Int J Food Microbiol. 1994 Sep;23(1):17-34 [7811570] Ann N Y Acad Sci. 1994 Dec 15;740:69-76 [7840480] Ann N Y Acad Sci. 1994 Dec 15;740:77-94 [7840481] Am J Public Health. 1995 Feb;85(2):168-72 [7856775] Int J Food Microbiol. 1994 Dec;24(1-2):11-31 [7703005] Int J Food Microbiol. 1994 Dec;24(1-2):171-8 [7703011] Crit Rev Toxicol. 1995;25(1):1-24 [7734058] Biotechnology. 1994;26:109-74 [7749302] J Infect Dis. 1995 Jun;171(6):1497-503 [7769284] Clin Neurol Neurosurg. 1995 May;97(2):119-24 [7656483] Ital J Gastroenterol. 1995 May;27(4):181-4 [8520034] Bull Pan Am Health Organ. 1995 Sep;29(3):279-81 [8520614] Biochemistry. 1996 Jan 9;35(1):243-50 [8555181] Trop Geogr Med. 1995;47(6):305-7 [8650747] Epidemiol Infect. 1996 Jun;116(3):339-46 [8666079] Int J Food Microbiol. 1995 Dec;28(2):157-68 [8750664] Epidemiol Infect. 1996 Aug;117(1):43-9 [8760949] N Engl J Med. 1996 Sep 12;335(11):783-9 [8703183] Neurotoxicology. 1995 Winter;16(4):629-38 [8714868] Neurotoxicology. 1995 Winter;16(4):717-26 [8714876] Science. 1996 Dec 20;274(5295):2025-31 [8953025] Public Health Rep. 1996 Nov-Dec;111(6):527-30 [8955700] Arch Intern Med. 1997 Jan 13;157(1):111-6 [8996048] Environ Health Perspect. 1997 Apr;105 Suppl 3:669-74 [9168012] World Health Stat Q. 1997;50(1-2):111-8 [9282393] Mol Biol Cell. 1997 Nov;8(11):2101-9 [9362055] Neurotoxicol Teratol. 1997 Nov-Dec;19(6):417-28 [9392777] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Fentanyl abuse and dependence: further evidence for second hand exposure hypothesis. Comments by Richard A. Denisco. AN - 68120609; 17088235 JF - Journal of addictive diseases AU - Denisco, Richard A AD - Division of Epidemiology, Services and Prevention Research, Natonal Institute on Drug Abuse, Bethesda, MD 20892, USA. deniscor@nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 137; discussion 141 EP - 4 VL - 25 IS - 4 SN - 1055-0887, 1055-0887 KW - Analgesics, Opioid KW - 0 KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Humans KW - Psychological Theory KW - Fentanyl -- adverse effects KW - Occupational Diseases -- etiology KW - Physicians KW - Occupational Diseases -- epidemiology KW - Anesthesiology KW - Analgesics, Opioid -- adverse effects KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68120609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Fentanyl+abuse+and+dependence%3A+further+evidence+for+second+hand+exposure+hypothesis.+Comments+by+Richard+A.+Denisco.&rft.au=Denisco%2C+Richard+A&rft.aulast=Denisco&rft.aufirst=Richard&rft.date=2006-01-01&rft.volume=25&rft.issue=4&rft.spage=137%3B+discussion+141&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Addict Dis. 2006;25(1):15-21 [16597569] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treating HIV during pregnancy: an update on safety issues. AN - 68048133; 16752931 AB - The expanded use of multiple antiretroviral drugs during pregnancy has led to a reduction in the occurrence of perinatal transmission of HIV to 250 cells/microL at treatment initiation and among pregnant women on long-term didanosine and stavudine. These drugs should be avoided in such situations if alternatives are available. Efavirenz has been associated with birth defects in monkeys, and several cases of neural tube defects have been reported in humans after first trimester exposure, so treatment with this drug should be avoided during the first trimester. Protease inhibitors have been associated with an increased risk of maternal glucose intolerance, pre-eclampsia and preterm birth in some, but not all, studies. Pregnancies exposed to antiretroviral therapy should be registered with the Antiretroviral Pregnancy Registry as early in pregnancy as possible in order to provide data on the risk of birth defects after exposure. The pharmacokinetics of nucleoside and non-nucleoside reverse transcriptase inhibitors are not significantly changed in pregnancy, so standard dosing may be used. However, concentrations of several protease inhibitors are lower in pregnancy, so ritonavir-boosting or increased doses are required. Of great theoretical concern is the impact of resistance mutations that develop following single-dose nevirapine therapy on the response to later therapy among women and their infected infants. The use of dual nucleoside therapy for 3-7 days after single-dose nevirapine in the mother reduces but does not eliminate the risk of nevirapine resistance; alternative regimens for prevention of resistance are under study, as are the subsequent responses of the mother and her infant to therapy. Short courses of prophylactic zidovudine and nevirapine have been well tolerated in neonates. Concern has been raised, however, that these exposures may lead to persistent mitochondrial dysfunction or later cancers, underscoring the need for long-term surveillance of antiretroviral-exposed, HIV-uninfected infants. JF - Drug safety AU - Watts, D Heather AD - Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Rockville, Maryland, USA. wattsh@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 467 EP - 490 VL - 29 IS - 6 SN - 0114-5916, 0114-5916 KW - Anti-HIV Agents KW - 0 KW - Reverse Transcriptase Inhibitors KW - Index Medicus KW - Infectious Disease Transmission, Vertical -- prevention & control KW - Animals KW - Humans KW - Infant, Newborn KW - Rabbits KW - Pregnancy KW - Rats KW - Drug Therapy, Combination KW - Dogs KW - HIV-1 -- drug effects KW - Female KW - Male KW - Pregnancy Outcome KW - Reverse Transcriptase Inhibitors -- adverse effects KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - Pregnancy Complications, Infectious -- drug therapy KW - Pregnancy Complications, Infectious -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68048133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Treating+HIV+during+pregnancy%3A+an+update+on+safety+issues.&rft.au=Watts%2C+D+Heather&rft.aulast=Watts&rft.aufirst=D&rft.date=2006-01-01&rft.volume=29&rft.issue=6&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-03 N1 - Date created - 2006-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gem protein signaling and regulation. AN - 68043725; 16757346 AB - Gem is a member of the RGK family of GTP-binding proteins within the Ras superfamily possessing a ras-like core and terminal extensions. We have used a variety of cell-based assays to investigate the physiological role of Gem and combined these assays with site-directed mutagenesis of Gem protein to identify the sites responsible for regulation of Gem activity. One function of Gem that has been explained is the inhibition of Rho kinase (ROK)-mediated cytoskeletal rearrangement. Transient expression of Gem in endothelial cells and stable transfection of fibroblasts resulted in decreased stress fiber formation and focal adhesion assembly. A neurite extension model using N1E-115 murine neuroblastoma showed that Gem inhibits actinomyosin-related contractility by specifically opposing ROKbeta activity. Phospho-specific antibodies were used in Western blot analysis to show that Gem prevents phosphorylation of the regulatory subunit of myosin light chain and myosin phosphatase by ROKbeta. On the contrary, LIMK, another substrate of ROKbeta, was unaffected by Gem expression as demonstrated by an in vitro kinase assay, suggesting that Gem exerts its effect by changing the substrate specificity of ROKbeta rather than by blocking its catalytic activity. Point mutations of Gem at serines 261 and 289 in the carboxyl-terminus inhibited Gem function, indicating that posttranslational phosphorylation of these serines regulates Gem's effect on cytoskeletal reorganization. Another biological role of Gem is inhibition of voltage-gated calcium channel activity. By use of a PC12 cell model combined with site-directed mutagenesis, we demonstrated that Gem inhibits growth hormone secretion stimulated by calcium influx through L-type calcium channels and that this function is dependent on GTP and calmodulin binding to Gem. The theory and method for the assays discussed previously are reviewed here. JF - Methods in enzymology AU - Ward, Yvona AU - Kelly, Kathleen AD - Cell and Cancer Biology Branch Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 468 EP - 483 VL - 407 SN - 0076-6879, 0076-6879 KW - Calcium Channels, L-Type KW - 0 KW - Myosin Light Chains KW - Growth Hormone KW - 9002-72-6 KW - Lim Kinases KW - EC 2.7.11.1 KW - rho-Associated Kinases KW - Myosin-Light-Chain Phosphatase KW - EC 3.1.3.53 KW - GEM protein, human KW - EC 3.6.5.2 KW - Monomeric GTP-Binding Proteins KW - Index Medicus KW - Neuroblastoma -- pathology KW - Animals KW - Neuroblastoma -- physiopathology KW - COS Cells KW - Humans KW - Protein Processing, Post-Translational KW - Cell Line, Tumor KW - Mice KW - Calcium Channels, L-Type -- drug effects KW - Lim Kinases -- metabolism KW - rho-Associated Kinases -- metabolism KW - Phosphorylation KW - Myosin-Light-Chain Phosphatase -- metabolism KW - Cercopithecus aethiops KW - Myosin Light Chains -- metabolism KW - Neurites -- pathology KW - Substrate Specificity KW - Growth Hormone -- secretion KW - Monomeric GTP-Binding Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68043725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Attention+Disorders&rft.atitle=Cognitive+behavioral+treatment+outcomes+in+adolescent+ADHD&rft.au=Antshel%2C+Kevin+M.%3BFaraone%2C+Stephen+V.%3BGordon%2C+Michael&rft.aulast=Antshel&rft.aufirst=Kevin&rft.date=2014-08-01&rft.volume=18&rft.issue=6&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Attention+Disorders&rft.issn=10870547&rft_id=info:doi/10.1177%2F1087054712443155 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resources for genetic and genomic studies of Xenopus. AN - 68031440; 16739712 AB - The National Institutes of Health Xenopus Initiative is a concerted effort to interact with the Xenopus research community to identify the community's needs; to devise strategies to meet those needs; and to support, oversee, and coordinate the resulting projects. This chapter provides a brief description of several genetic and genomic resources generated by this initiative and explains how to access them. The resources described in this chapter are (1) complementary deoxyribonucleic acid (cDNA) libraries and expressed sequence tag (EST) sequences; (2) UniGene clusters; (3) full-insert cDNA sequences; (4) a genetic map; (5) genomic libraries; (6) a physical map; (7) genome sequence; (8) microarrays; (9) mutagenesis and phenotyping; and (10) bioinformatics. The descriptions presented here were based on data that were available at the time of manuscript submission. Because these are ongoing projects, they are constantly generating new data and analyses. The Web sites cited in each subheading present current data and analyses. JF - Methods in molecular biology (Clifton, N.J.) AU - Klein, Steven L AU - Gerhard, Daniela S AU - Wagner, Lukas AU - Richardson, Paul AU - Schriml, Lynn M AU - Sater, Amy K AU - Warren, Wesley C AU - McPherson, John D AD - Developmental Biology, Genetics, and Teratology Branch, National Institute of Child Health and Human Development, Rockville, MD, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 1 EP - 16 VL - 322 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - United States KW - Animals KW - National Library of Medicine (U.S.) KW - Humans KW - National Institutes of Health (U.S.) KW - Developmental Biology -- trends KW - Developmental Biology -- methods KW - Xenopus -- genetics KW - Xenopus -- embryology KW - Xenopus -- growth & development KW - Computational Biology -- methods KW - Internet KW - Genomics KW - Gene Library KW - Computational Biology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68031440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Resources+for+genetic+and+genomic+studies+of+Xenopus.&rft.au=Klein%2C+Steven+L%3BGerhard%2C+Daniela+S%3BWagner%2C+Lukas%3BRichardson%2C+Paul%3BSchriml%2C+Lynn+M%3BSater%2C+Amy+K%3BWarren%2C+Wesley+C%3BMcPherson%2C+John+D&rft.aulast=Klein&rft.aufirst=Steven&rft.date=2006-01-01&rft.volume=322&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues related to the pharmacological management of patients with brain tumours and epilepsy. AN - 68024042; 16734997 AB - The patient affected by epilepsy related to brain tumours presents certain features linked to the summation of his cancer-related problems and his epilepsy-related problems. Furthermore, epilepsy in brain tumour patients is often refractory to pharmacological treatments and can complicate the therapeutic management of these patients due to the increased incidence of pharmacological interactions and adverse effects. Analysis of the data in the literature suggests that it is opportune, when planning antiepileptic therapy in these cases, to choose the new-generation drugs, as these show a lower incidence of pharmacological interactions with the therapies used in brain tumour patients (chemotherapies, radiotherapy and support therapies), have fewer adverse effects, and have less impact on neuropsychological functions, all factors that strongly influence the patient's quality of life. Of the new antiepileptic drugs, the following seem to be promising in the treatment of cancer-related epilepsy: oxcarbazepine, topiramate and levetiracetam (the latter as an add-on therapy). The pharmacokinetic features of these drugs, their effectiveness in controlling seizures, and the reduced incidence of adverse effects make them useful in this particular group of patients. JF - Functional neurology AU - Maschio, Marta AU - Dinapoli, Loredana AU - Zarabia, Alessia AU - Jandolo, Bruno AD - Epilepsy Outpatient Centre, Department of Neuroscience and Cervical-Facial Pathology, Regina Elena National Cancer Institute, Rome, Italy. maschio@ifo.it PY - 2006 SP - 15 EP - 19 VL - 21 IS - 1 SN - 0393-5264, 0393-5264 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Drug Interactions KW - Humans KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- complications KW - Anticonvulsants -- metabolism KW - Anticonvulsants -- adverse effects KW - Epilepsy -- metabolism KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Epilepsy -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68024042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Functional+neurology&rft.atitle=Issues+related+to+the+pharmacological+management+of+patients+with+brain+tumours+and+epilepsy.&rft.au=Maschio%2C+Marta%3BDinapoli%2C+Loredana%3BZarabia%2C+Alessia%3BJandolo%2C+Bruno&rft.aulast=Maschio&rft.aufirst=Marta&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Functional+neurology&rft.issn=03935264&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-07 N1 - Date created - 2006-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. AN - 67997708; 16714450 AB - Cells deficient in the Werner syndrome protein (WRN) or BRCA1 are hypersensitive to DNA interstrand cross-links (ICLs), whose repair requires nucleotide excision repair (NER) and homologous recombination (HR). However, the roles of WRN and BRCA1 in the repair of DNA ICLs are not understood and the molecular mechanisms of ICL repair at the processing stage have not yet been established. This study demonstrates that WRN helicase activity, but not exonuclease activity, is required to process DNA ICLs in cells and that WRN cooperates with BRCA1 in the cellular response to DNA ICLs. BRCA1 interacts directly with WRN and stimulates WRN helicase and exonuclease activities in vitro. The interaction between WRN and BRCA1 increases in cells treated with DNA cross-linking agents. WRN binding to BRCA1 was mapped to BRCA1 452-1079 amino acids. The BRCA1/BARD1 complex also associates with WRN in vivo and stimulates WRN helicase activity on forked and Holliday junction substrates. These findings suggest that WRN and BRCA1 act in a coordinated manner to facilitate repair of DNA ICLs. JF - Nucleic acids research AU - Cheng, Wen-Hsing AU - Kusumoto, Rika AU - Opresko, Patricia L AU - Sui, XiuFen AU - Huang, Shurong AU - Nicolette, Matthew L AU - Paull, Tanya T AU - Campisi, Judith AU - Seidman, Michael AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 2751 EP - 2760 VL - 34 IS - 9 KW - BRCA1 Protein KW - 0 KW - Cross-Linking Reagents KW - Exodeoxyribonucleases KW - EC 3.1.- KW - Exonucleases KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Ficusin KW - KTZ7ZCN2EX KW - Index Medicus KW - HeLa Cells KW - Humans KW - Cross-Linking Reagents -- toxicity KW - Immunoprecipitation KW - Cell Line, Tumor KW - RNA Interference KW - Ficusin -- toxicity KW - Cell Proliferation KW - Exonucleases -- metabolism KW - BRCA1 Protein -- antagonists & inhibitors KW - DNA Repair KW - DNA Helicases -- physiology KW - DNA Damage KW - DNA Helicases -- antagonists & inhibitors KW - BRCA1 Protein -- physiology KW - BRCA1 Protein -- genetics KW - DNA Helicases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67997708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Collaboration+of+Werner+syndrome+protein+and+BRCA1+in+cellular+responses+to+DNA+interstrand+cross-links.&rft.au=Cheng%2C+Wen-Hsing%3BKusumoto%2C+Rika%3BOpresko%2C+Patricia+L%3BSui%2C+XiuFen%3BHuang%2C+Shurong%3BNicolette%2C+Matthew+L%3BPaull%2C+Tanya+T%3BCampisi%2C+Judith%3BSeidman%2C+Michael%3BBohr%2C+Vilhelm+A&rft.aulast=Cheng&rft.aufirst=Wen-Hsing&rft.date=2006-01-01&rft.volume=34&rft.issue=9&rft.spage=2751&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-30 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Oct;4(4):511-8 [10549283] Cancer Res. 2006 Feb 15;66(4):2012-8 [16489000] Genes Dev. 2000 Apr 15;14(8):907-12 [10783163] J Biol Chem. 2000 Aug 4;275(31):23899-903 [10843985] Mol Cell. 2001 Feb;7(2):249-62 [11239454] EMBO Rep. 2000 Jul;1(1):80-4 [11256630] Genes Dev. 2001 Apr 15;15(8):933-8 [11316787] FASEB J. 2001 May;15(7):1224-6 [11344095] Proc Natl Acad Sci U S A. 2001 May 22;98(11):6086-91 [11353843] Genes Cells. 2001 May;6(5):421-30 [11380620] Nucleic Acids Res. 2001 Jul 1;29(13):2843-9 [11433031] Mutat Res. 2001 Sep 4;486(4):217-47 [11516927] J Biol Chem. 2001 Oct 12;276(41):38242-8 [11477099] J Biol Chem. 2001 Nov 30;276(48):44677-87 [11572872] Environ Mol Mutagen. 2001;38(2-3):227-34 [11746759] Nat Genet. 2002 Mar;30(3):285-9 [11836499] FASEB J. 2002 May;16(7):757-8 [11978740] J Biol Chem. 2002 May 24;277(21):18291-302 [11889123] Hum Mol Genet. 2002 Oct 1;11(21):2591-7 [12354784] Genes Dev. 2003 Jan 15;17(2):201-13 [12533509] J Biol Chem. 2003 Mar 28;278(13):11072-7 [12538585] Nat Rev Mol Cell Biol. 2003 Jun;4(6):435-45 [12778123] Cancer Res. 2003 Jun 15;63(12):3289-95 [12810661] Aging Cell. 2003 Aug;2(4):191-9 [12934712] Mol Cell Biol. 2003 Sep;23(18):6385-95 [12944467] J Cell Biol. 2003 Sep 29;162(7):1197-209 [14517203] Mol Cell Biol. 2003 Dec;23(23):8601-13 [14612404] Mol Cell. 2003 Nov;12(5):1087-99 [14636569] Mol Cell Biol. 2004 Jan;24(1):123-34 [14673148] Nat Cell Biol. 2004 Feb;6(2):168-70 [14755273] Nat Rev Cancer. 2004 Apr;4(4):266-76 [15057286] J Biol Chem. 2004 May 14;279(20):21169-76 [15026416] J Biol Chem. 2004 Jul 23;279(30):31251-8 [15159397] EMBO J. 2004 Aug 4;23(15):3154-63 [15257300] Nucleic Acids Res. 2004;32(13):4003-14 [15292449] J Cell Physiol. 1977 Sep;92(3):365-74 [903377] Nat Genet. 1996 Dec;14(4):430-40 [8944023] Cell. 1997 Jan 24;88(2):265-75 [9008167] Nat Genet. 1998 Oct;20(2):212-4 [9771719] Science. 1999 Jul 30;285(5428):747-50 [10426999] Nucleic Acids Res. 1999 Sep 1;27(17):3557-66 [10446247] Hum Genet. 1999 Jul-Aug;105(1-2):132-8 [10480367] Cancer Cell. 2004 Dec;6(6):539-45 [15607958] FEBS Lett. 2005 Feb 28;579(6):1350-6 [15733840] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] Nat Genet. 2005 Sep;37(9):934-5 [16116423] Nat Genet. 2005 Sep;37(9):931-3 [16116424] Nat Genet. 2005 Sep;37(9):921-2 [16132046] J Cell Sci. 2005 Sep 15;118(Pt 18):4153-62 [16141234] Biochem Biophys Res Commun. 2005 Oct 28;336(3):952-60 [16165098] Cancer Res. 2005 Dec 15;65(24):11384-91 [16357146] Genes Dev. 2005 Dec 15;19(24):3055-69 [16357221] Nat Genet. 2000 Jan;24(1):16-7 [10615119] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Screening the receptorome yields validated molecular targets for drug discovery. AN - 67994719; 16712488 AB - With the recently completed sequencing and annotation of the human genome, it has become clear that a significant portion of the genome encodes signal-transducing molecules including receptors, protein kinases, ion channels, transporters and coupling proteins. This review focuses on membrane-localized receptors, which represent the largest single group of signal-transducing molecules. Indeed, one can estimate that nearly 10% of the human genome encodes membrane-localized receptors (e.g. G-protein coupled receptors, ligand-gated ion channels and transporters). We have defined that portion of the human genome that encodes 'receptors' the receptorome. In this article, we will demonstrate how the massively parallel screening of the receptorome provides a facile and under-utilized screening platform for drug discovery. Using case studies, we will show how receptorome-based screening elucidates the mechanisms responsible for serious side-effects of both approved and investigational medications. Additionally, we will provide evidence that receptorome-based screening provides insights into novel therapeutic indications of approved medications and serves to validate targets for therapeutic drug discovery. JF - Current pharmaceutical design AU - Roth, Bryan L AU - Kroeze, Wesley K AD - Department of Biochemistry, CASE Comprehensive Cancer Center, National Institute of Mental Health Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, OH 44106, USA. bryan.roth@case.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 1785 EP - 1795 VL - 12 IS - 14 SN - 1381-6128, 1381-6128 KW - Antipsychotic Agents KW - 0 KW - Receptors, Cell Surface KW - Index Medicus KW - Obesity -- drug therapy KW - Weight Gain -- drug effects KW - Genome, Human KW - Humans KW - Antipsychotic Agents -- pharmacology KW - Ephedra KW - Antipsychotic Agents -- adverse effects KW - Receptors, Cell Surface -- genetics KW - Drug Design KW - Receptors, Cell Surface -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67994719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=Screening+the+receptorome+yields+validated+molecular+targets+for+drug+discovery.&rft.au=Roth%2C+Bryan+L%3BKroeze%2C+Wesley+K&rft.aulast=Roth&rft.aufirst=Bryan&rft.date=2006-01-01&rft.volume=12&rft.issue=14&rft.spage=1785&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=13816128&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [The risks of out of area missions: depleted uranium]. TT - I rischi delle missioni fuori area: l'uranio impoverito. AN - 67978776; 16705900 AB - Depleted uranium (DU), a waste product of uranium enrichment, has several civilian and military applications. It was used as armor-piercing ammunition in international conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome. Leukaemia/Limphoma cases among UN soldiers in the Balkans have been related hypothetically to exposure to DU. The investigations published in the scientific literature give no support for this hypothesis. However future follow-up is necessary for evaluation of long-term risk. JF - Giornale italiano di medicina del lavoro ed ergonomia AU - Ciprani, F AU - Moroni, M AD - Dipartimento della P.S., Direzione Centrale di Sanità, Osservatorio Centrale per la Tutela della Salute e della Sicurezza nei Luoghi di Lavoro. PY - 2006 SP - 115 EP - 121 VL - 28 IS - 1 SN - 1592-7830, 1592-7830 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Mass Spectrometry KW - Lymphoma -- diagnosis KW - Lymphoma -- etiology KW - Yugoslavia KW - Risk Factors KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Fluorometry KW - United Nations KW - Leukemia, Radiation-Induced -- diagnosis KW - Environmental Exposure -- adverse effects KW - Warfare KW - Uranium -- urine KW - Neoplasms, Radiation-Induced -- etiology KW - Military Personnel KW - Persian Gulf Syndrome -- diagnosis KW - Uranium -- adverse effects KW - Neoplasms, Radiation-Induced -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67978776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Giornale+italiano+di+medicina+del+lavoro+ed+ergonomia&rft.atitle=%5BThe+risks+of+out+of+area+missions%3A+depleted+uranium%5D.&rft.au=Ciprani%2C+F%3BMoroni%2C+M&rft.aulast=Ciprani&rft.aufirst=F&rft.date=2006-01-01&rft.volume=28&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Giornale+italiano+di+medicina+del+lavoro+ed+ergonomia&rft.issn=15927830&rft_id=info:doi/ LA - Italian DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxic lymphocytes for the clinic. AN - 67964248; 16698682 JF - Cytotherapy AU - Barrett, A J AU - Sharp, J G AD - National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 93 EP - 94 VL - 8 IS - 2 SN - 1465-3249, 1465-3249 KW - Index Medicus KW - Cytotoxicity, Immunologic KW - Humans KW - Cytotoxicity Tests, Immunologic KW - T-Lymphocytes, Cytotoxic -- physiology KW - Hematologic Neoplasms -- therapy KW - T-Lymphocytes -- cytology KW - Lymphocytes -- immunology KW - Hematologic Neoplasms -- physiopathology KW - T-Lymphocytes, Cytotoxic -- cytology KW - Hematologic Neoplasms -- immunology KW - T-Lymphocytes, Cytotoxic -- immunology KW - T-Lymphocytes -- physiology KW - Lymphocytes -- cytology KW - Lymphocytes -- physiology KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67964248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytotherapy&rft.atitle=Cytotoxic+lymphocytes+for+the+clinic.&rft.au=Barrett%2C+A+J%3BSharp%2C+J+G&rft.aulast=Barrett&rft.aufirst=A&rft.date=2006-01-01&rft.volume=8&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Cytotherapy&rft.issn=14653249&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-06 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cytotherapy. 2006;8(2):105-17 [16698684] Cytotherapy. 2006;8(2):141-8 [16698687] Cytotherapy. 2006;8(2):118-29 [16698685] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. AN - 67963226; 16684666 AB - Significant restriction of growth of Ehrlich's carcinoma was observed following prophylactic treatment on Swiss albino mice with neem leaf preparation (NLP-1 unit) once weekly for four weeks. Toxic effects of this particular dose (1 unit), along with 0.5 unit and 2 units of NLP doses, were evaluated on different murine physiological systems. One hundred percent of mice could tolerate 4 injections of 0.5 and 1 unit NLP doses. Body weight, different organ-body weight ratios and physical behavior of treated mice remained completely unchanged during treatment with different NLP doses. All of these NLP doses were observed to stimulate hematological systems as evidenced by the increase in total count of RBC, WBC and platelets and hemoglobin percentage. As histological changes as well as elevation in serum alkaline phosphatase, SGOT, SGPT were not observed in mice treated with three different doses of NLP, the nonhepatotoxic nature of NLP was proved. The level of serum urea remained unaltered and normal architecture of the cortical and medullary parts of the kidney were also preserved after NLP treatment. Increased antibody production against B16 melanoma antigen was detected in mice immunized with 0.5 unit and 1 unit of NLP. Number of splenic T lymphocytes (CD4+ and CD8+) and NK cells were also observed to be increased in mice injected with 0.5 unit and 1 unit of NLP. However, NLP dose of 2 units could not exhibit such immunostimulatory changes; NLP mediated immunostimulation was correlated well with the growth restriction of murine carcinoma. In other words, tumor growth restriction was observed only when mice were injected with immunostimulatory doses of NLP (0.5 unit and 1 unit). JF - Immunopharmacology and immunotoxicology AU - Haque, Enamul AU - Mandal, Ishita AU - Pal, Smarajit AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2006 PY - 2006 DA - 2006 SP - 33 EP - 50 VL - 28 IS - 1 SN - 0892-3973, 0892-3973 KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Neoplasm KW - Antineoplastic Agents, Phytogenic KW - Plant Extracts KW - Index Medicus KW - Animals KW - Kidney Function Tests KW - Dose-Response Relationship, Drug KW - Plant Leaves -- adverse effects KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Carcinoma, Ehrlich Tumor -- pathology KW - Mice KW - Plant Leaves -- chemistry KW - Melanoma, Experimental -- pathology KW - Antibodies, Neoplasm -- biosynthesis KW - Liver Function Tests KW - Plant Extracts -- adverse effects KW - Blood Cell Count KW - Stimulation, Chemical KW - Lymphocyte Count KW - Plant Extracts -- therapeutic use KW - Body Weight -- drug effects KW - Melanoma, Experimental -- drug therapy KW - Female KW - Killer Cells, Natural -- immunology KW - Survival Analysis KW - Organ Size -- drug effects KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Azadirachta -- chemistry KW - Hematopoietic System -- drug effects KW - Adjuvants, Immunologic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67963226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology+and+immunotoxicology&rft.atitle=Prophylactic+dose+of+neem+%28Azadirachta+indica%29+leaf+preparation+restricting+murine+tumor+growth+is+nontoxic%2C+hematostimulatory+and+immunostimulatory.&rft.au=Haque%2C+Enamul%3BMandal%2C+Ishita%3BPal%2C+Smarajit%3BBaral%2C+Rathindranath&rft.aulast=Haque&rft.aufirst=Enamul&rft.date=2006-01-01&rft.volume=28&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology+and+immunotoxicology&rft.issn=08923973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. AN - 67951732; 16681430 AB - The immunoglobulin superfamily receptor translocation-associated 2 (IRTA2) gene encodes both membrane and secreted forms of the B-cell differentiation antigen (also identified as FcRH5). The membrane form is highly expressed on the surface of hairy cell leukemia (HCL) cells from patients. This study aimed to develop immunoassays for soluble IRTA2/FcRH5 proteins in human serum. Two sandwich ELISAs for soluble IRTA2/FcRH5 were designed using two pairs of monoclonal antibodies specific to four different epitopes on IRTA2/FcRH5. In both ELISAs, the lower limit of quantitation for soluble IRTA2/FcRH5 in human serum was 30 ng/mL. The analytical recovery of 0.3-2.1 ng/mL of IRTA2/FcRH5-Fc used as the standard, from a 100-fold dilution of IRTA2/FcRH5-free sera, was 94-106% for ELISA #1 and 89-97% for ELISA #2. Between-assay coefficients of variance were 7.7-17.6% for ELISA #1 and 7.7-32.7% for ELISA #2. Both ELISAs detected soluble IRTA2/FcRH5 protein in sera from normal donors (median 169 ng/mL in ELISA #1 and 146 ng/mL in ELISA #2, n=123) without correlations to gender or age. A marked increase in soluble IRTA2/FcRH5 levels was observed in samples from patients with HCL (medians 719 ng/mL in ELISA #1 and 754 ng/mL in ELISA #2, n=44). These ELISAs may be useful for monitoring soluble IRTA2/FcRH5 in HCL and other B-cell malignancies. JF - Clinical chemistry and laboratory medicine AU - Ise, Tomoko AU - Kreitman, Robert J AU - Pastan, Ira AU - Nagata, Satoshi AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 594 EP - 602 VL - 44 IS - 5 SN - 1434-6621, 1434-6621 KW - Biomarkers, Tumor KW - 0 KW - Epitopes KW - FCRL5 protein, human KW - Immunoglobulins KW - Immunotoxins KW - Receptors, Cell Surface KW - Receptors, Fc KW - Index Medicus KW - Leukemia, Hairy Cell -- blood KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Epitopes -- chemistry KW - Immunotoxins -- metabolism KW - Adolescent KW - Leukemia, Hairy Cell -- diagnosis KW - Male KW - Female KW - Biomarkers, Tumor -- metabolism KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Immunoglobulins -- chemistry KW - Receptors, Cell Surface -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67951732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3A&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=Violent+Offenders+in+State+Prison%3A+Sentences+and+Time+Served&rft.au=Beck%2C+A+J%3BGreenfield%2C+L+A&rft.aulast=Beck&rft.aufirst=A&rft.date=1995-01-01&rft.volume=47&rft.issue=6&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31816bff88 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-14 N1 - Date created - 2006-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-specific and mitochondrial repair of oxidative DNA damage. AN - 67931576; 16673881 AB - The Southern blot gene-specific DNA damage and repair assay is a robust and flexible method for quantifying many kinds of induced damage and repair with high reproducibility. Specific nicking and loss of a restricted DNA fragment at the site of induced damage is visualized by Southern blot and quantified against a control; since the blot is gene specific, only the damage of interest is measured. Here we show how the assay may be adapted to assess mitochondrial DNA (mtDNA) damage. In the mitochondrion, 8-oxoguanine is a significant oxidative lesion; in the laboratory, photoactivated methylene blue may be used to introduce this lesion into cells. Other lesions may also be studied by using different DNA damaging agents. We find that damage induction by methylene blue is consistently far greater in the mitochondrion than the nucleus. Thus advantageously, mitochondrial 8-oxoguanine repair may be studied without mtDNA isolation or preparation, which are processes known to induce DNA damage and skew measurements. This chapter gives detailed instructions for using methylene blue and the gene-specific repair assay to accurately measure mitochondrial oxidative damage and repair rates. JF - Methods in molecular biology (Clifton, N.J.) AU - Anson, R Michael AU - Mason, Penelope A AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 155 EP - 181 VL - 314 SN - 1064-3745, 1064-3745 KW - DNA, Mitochondrial KW - 0 KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - Methylene Blue KW - T42P99266K KW - Index Medicus KW - Humans KW - Mitochondria -- drug effects KW - Methylene Blue -- toxicity KW - Guanine -- analogs & derivatives KW - Cell Nucleus -- drug effects KW - Guanine -- metabolism KW - Cell Line KW - DNA, Mitochondrial -- drug effects KW - DNA Repair KW - DNA Damage KW - Blotting, Southern -- methods KW - Oxidative Stress KW - DNA, Mitochondrial -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67931576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Gene-specific+and+mitochondrial+repair+of+oxidative+DNA+damage.&rft.au=Anson%2C+R+Michael%3BMason%2C+Penelope+A%3BBohr%2C+Vilhelm+A&rft.aulast=Anson&rft.aufirst=R&rft.date=2006-01-01&rft.volume=314&rft.issue=&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis. AN - 67930375; 16669178 AB - The purpose of this study was to describe and compare the cardiac magnetic resonance (CMR) characteristics of myocarditis caused by high dose interleukin-2 (7 patients) with community-acquired myocarditis (14 patients). A total of 21 patients with suspected myocarditis and elevated cardiac enzymes underwent cine CMR followed by delayed enhancement. The mean ejection fraction was mildly decreased in both groups. The location, pattern, and extent of DE were similar in both groups of patients. The CMR similarities between these two populations suggest that cytokine-mediated cytotoxicity may play an important role in community-acquired myocarditis. JF - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance AU - Ingkanisorn, W Patricia AU - Paterson, D Ian AU - Calvo, Katherine R AU - Rosing, Douglas R AU - Schwartzentruber, Douglas J AU - Fuisz, Anthon R AU - Arai, Andrew E AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1061, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 353 EP - 360 VL - 8 IS - 2 SN - 1097-6647, 1097-6647 KW - Antineoplastic Agents KW - 0 KW - Interleukin-2 KW - Index Medicus KW - Humans KW - Melanoma -- drug therapy KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Statistics, Nonparametric KW - Male KW - Female KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Magnetic Resonance Imaging, Cine -- methods KW - Myocarditis -- chemically induced KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+magnetic+resonance+%3A+official+journal+of+the+Society+for+Cardiovascular+Magnetic+Resonance&rft.atitle=Cardiac+magnetic+resonance+appearance+of+myocarditis+caused+by+high+dose+IL-2%3A+similarities+to+community-acquired+myocarditis.&rft.au=Ingkanisorn%2C+W+Patricia%3BPaterson%2C+D+Ian%3BCalvo%2C+Katherine+R%3BRosing%2C+Douglas+R%3BSchwartzentruber%2C+Douglas+J%3BFuisz%2C+Anthon+R%3BArai%2C+Andrew+E&rft.aulast=Ingkanisorn&rft.aufirst=W&rft.date=2006-01-01&rft.volume=8&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+magnetic+resonance+%3A+official+journal+of+the+Society+for+Cardiovascular+Magnetic+Resonance&rft.issn=10976647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chaperoning oncogenes: Hsp90 as a target of geldanamycin. AN - 67855152; 16610363 AB - Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signaling proteins, as well as multiple mutated, chimeric, and/or over-expressed signaling proteins, that promote cancer cell growth and/or survival. Hsp90 inhibitors, by interacting specifically with a single molecular target, cause the inactivation, destabilization, and eventual degradation of Hsp90 client proteins, and they have shown promising anti-tumor activity in preclinical model systems. One Hsp90 inhibitor, 17-AAG, has completed Phase I clinical trial and several Phase II trials of this agent are in progress. Hsp90 inhibitors are unique in that, although they are directed toward a specific molecular target, they simultaneously inhibit multiple signaling pathways that frequently interact to promote cancer cell survival. Further, by inhibiting nodal points in multiple overlapping survival pathways utilized by cancer cells, a combination of an Hsp90 inhibitor with standard chemotherapeutic agents may dramatically increase the in vivo efficacy of the standard agent. Hsp90 inhibitors may circumvent the characteristic genetic plasticity that has allowed cancer cells to eventually evade the toxic effects of most molecularly targeted agents. The mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs, should be effective toward multiple forms of cancer. JF - Handbook of experimental pharmacology AU - Neckers, L AD - Urologic Oncology Branch, National Cancer Institute, Rockville MD, 20850, USA. len@helix.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 259 EP - 277 IS - 172 SN - 0171-2004, 0171-2004 KW - Angiogenesis Inhibitors KW - 0 KW - Antibiotics, Antineoplastic KW - Benzoquinones KW - HIF1A protein, human KW - HSP90 Heat-Shock Proteins KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Lactams, Macrocyclic KW - Quinones KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Animals KW - Angiogenesis Inhibitors -- pharmacology KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Endoplasmic Reticulum -- drug effects KW - Oncogenes KW - Antibiotics, Antineoplastic -- pharmacology KW - HSP90 Heat-Shock Proteins -- physiology KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Quinones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67855152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Chaperoning+oncogenes%3A+Hsp90+as+a+target+of+geldanamycin.&rft.au=Neckers%2C+L&rft.aulast=Neckers&rft.aufirst=L&rft.date=2006-01-01&rft.volume=&rft.issue=172&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factor V Leiden as a common genetic risk factor for venous thromboembolism. AN - 67819864; 16579319 AB - To increase nurses' knowledge of the Factor V Leiden (FVL) genetic trait for venous thromboembolism. An overview of the history, prevalence, and predisposition of the FVL genetic mutation, including who should be tested and how and in what circumstances people with FVL should be treated. FVL is the most commonly recognized genetic trait associated with venous thrombosis. It is found predominantly in Caucasian populations. Biochemically it causes "activated protein C resistance (APCR)." The decision to test for FVL depends on whether the information gained will potentially improve the health care of the person or family. For people who have had deep venous thrombosis, testing for FVL will likely not alter treatment approaches. Currently the advantage for testing is primarily limited to asymptomatic family members who carry FVL and who have had deep vein thrombosis. Close relatives who also carry the mutated gene might benefit from prophylactic anticoagulation when their risk of thrombosis is increased by temporary factors such as surgery. Nurses are in a unique position to provide accurate information and counseling when patients and their family members are presented with the results of thrombophilia testing. JF - Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing AU - Horne, McDonald K AU - McCloskey, Donna Jo AD - Department of Laboratory Medicine, National Institute of Nursing Research, National Institutes of Health, Bethesda 20892, USA. mccloskd@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 19 EP - 25 VL - 38 IS - 1 SN - 1527-6546, 1527-6546 KW - Anticoagulants KW - 0 KW - factor V Leiden KW - Factor V KW - 9001-24-5 KW - Index Medicus KW - Nursing KW - Pedigree KW - Anticoagulants -- therapeutic use KW - Humans KW - Aged KW - European Continental Ancestry Group -- statistics & numerical data KW - Patient Selection KW - European Continental Ancestry Group -- genetics KW - Genetic Counseling KW - Age Distribution KW - Global Health KW - Genetic Testing KW - Patient Education as Topic KW - Heterozygote Detection KW - Estrogen Replacement Therapy -- adverse effects KW - Risk Factors KW - Adult KW - Nurse's Role KW - Incidence KW - Middle Aged KW - Prevalence KW - Activated Protein C Resistance -- diagnosis KW - Genetic Predisposition to Disease -- prevention & control KW - Thromboembolism -- epidemiology KW - Genetic Predisposition to Disease -- genetics KW - Activated Protein C Resistance -- genetics KW - Venous Thrombosis -- prevention & control KW - Thromboembolism -- prevention & control KW - Genetic Predisposition to Disease -- epidemiology KW - Activated Protein C Resistance -- epidemiology KW - Venous Thrombosis -- genetics KW - Venous Thrombosis -- epidemiology KW - Thromboembolism -- genetics KW - Factor V -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67819864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nursing+scholarship+%3A+an+official+publication+of+Sigma+Theta+Tau+International+Honor+Society+of+Nursing&rft.atitle=Factor+V+Leiden+as+a+common+genetic+risk+factor+for+venous+thromboembolism.&rft.au=Horne%2C+McDonald+K%3BMcCloskey%2C+Donna+Jo&rft.aulast=Horne&rft.aufirst=McDonald&rft.date=2006-01-01&rft.volume=38&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+nursing+scholarship+%3A+an+official+publication+of+Sigma+Theta+Tau+International+Honor+Society+of+Nursing&rft.issn=15276546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-05 N1 - Date created - 2006-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of hippocampal lesions on the monkey's ability to learn large sets of object-place associations. AN - 67811708; 16358315 AB - Earlier studies found that recognition memory for object-place associations was impaired in patients with relatively selective hippocampal damage (Vargha-Khadem et al., Science 1997; 277:376-380), but was unaffected after selective hippocampal lesions in monkeys (Malkova and Mishkin, J Neurosci 2003; 23:1956-1965). A potentially important methodological difference between the two studies is that the patients were required to remember a set of 20 object-place associations for several minutes, whereas the monkeys had to remember only two such associations at a time, and only for a few seconds. To approximate more closely the task given to the patients, we trained monkeys on several successive sets of 10 object-place pairs each, with each set requiring learning across days. Despite the increased associative memory demands, monkeys given hippocampal lesions were unimpaired relative to their unoperated controls, suggesting that differences other than set size and memory duration underlie the different outcomes in the human and animal studies. (c) 2005 Wiley-Liss, Inc. JF - Hippocampus AU - Belcher, Annabelle M AU - Harrington, Rebecca A AU - Malkova, Ludise AU - Mishkin, Mortimer AD - Laboratory of Neuropsychology, NIMH, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 361 EP - 367 VL - 16 IS - 4 SN - 1050-9631, 1050-9631 KW - Neurotoxins KW - 0 KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Orientation -- physiology KW - Animals KW - Space Perception -- drug effects KW - Space Perception -- physiology KW - Orientation -- drug effects KW - Neurotoxins -- pharmacology KW - Disease Models, Animal KW - Neuropsychological Tests KW - Denervation KW - Male KW - Female KW - Ibotenic Acid -- pharmacology KW - Macaca mulatta -- anatomy & histology KW - Hippocampus -- physiology KW - Memory -- drug effects KW - Learning -- physiology KW - Memory -- physiology KW - Learning -- drug effects KW - Macaca mulatta -- physiology KW - Macaca mulatta -- psychology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67811708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hippocampus&rft.atitle=Effects+of+hippocampal+lesions+on+the+monkey%27s+ability+to+learn+large+sets+of+object-place+associations.&rft.au=Belcher%2C+Annabelle+M%3BHarrington%2C+Rebecca+A%3BMalkova%2C+Ludise%3BMishkin%2C+Mortimer&rft.aulast=Belcher&rft.aufirst=Annabelle&rft.date=2006-01-01&rft.volume=31&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychopharmacology&rft.issn=02710749&rft_id=info:doi/10.1097%2FJCP.0b013e3182060f3f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. AN - 67770581; 16549874 AB - Human 8-oxoguanine-DNA glycosylase (OGG1) is the major enzyme for repairing 8-oxoguanine (8-oxoG), a mutagenic guanine base lesion produced by reactive oxygen species (ROS). A frequently occurring OGG1 polymorphism in human populations results in the substitution of serine 326 for cysteine (S326C). The 326 C/C genotype is linked to numerous cancers, although the mechanism of carcinogenesis associated with the variant is unclear. We performed detailed enzymatic studies of polymorphic OGG1 and found functional defects in the enzyme. S326C OGG1 excised 8-oxoG from duplex DNA and cleaved abasic sites at rates 2- to 6-fold lower than the wild-type enzyme, depending upon the base opposite the lesion. Binding experiments showed that the polymorphic OGG1 binds DNA damage with significantly less affinity than the wild-type enzyme. Remarkably, gel shift, chemical cross-linking and gel filtration experiments showed that S326C both exists in solution and binds damaged DNA as a dimer. S326C OGG1 enzyme expressed in human cells was also found to have reduced activity and a dimeric conformation. The glycosylase activity of S326C OGG1 was not significantly stimulated by the presence of AP-endonuclease. The altered substrate specificity, lack of stimulation by AP-endonuclease 1 (APE1) and anomalous DNA binding conformation of S326C OGG1 may contribute to its linkage to cancer incidence. JF - Nucleic acids research AU - Hill, Jeff W AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 1620 EP - 1632 VL - 34 IS - 5 KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - DNA KW - 9007-49-2 KW - DNA Glycosylases KW - EC 3.2.2.- KW - oxoguanine glycosylase 1, human KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Cysteine -- chemistry KW - DNA Repair KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- metabolism KW - HeLa Cells KW - Humans KW - Dimerization KW - DNA -- metabolism KW - Guanine -- analogs & derivatives KW - Guanine -- metabolism KW - Amino Acid Substitution KW - Catalysis KW - DNA Glycosylases -- chemistry KW - Polymorphism, Genetic KW - DNA Glycosylases -- metabolism KW - DNA Glycosylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67770581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Dimerization+and+opposite+base-dependent+catalytic+impairment+of+polymorphic+S326C+OGG1+glycosylase.&rft.au=Hill%2C+Jeff+W%3BEvans%2C+Michele+K&rft.aulast=Hill&rft.aufirst=Jeff&rft.date=2006-01-01&rft.volume=34&rft.issue=5&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-05 N1 - Date created - 2006-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1998 Nov 15;26(22):5116-22 [9801308] Biochem Biophys Res Commun. 1999 May 19;258(3):605-10 [10329432] Nucleic Acids Res. 1999 Oct 15;27(20):4001-7 [10497264] Carcinogenesis. 2004 Nov;25(11):2177-81 [15284179] Annu Rev Genet. 2004;38:445-76 [15568983] Mol Carcinog. 2005 Mar;42(3):127-41 [15584022] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3523-8 [11904416] Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):409-12 [11927502] Cancer Res. 2002 Apr 15;62(8):2253-7 [11956079] Int J Cancer. 2002 Jun 1;99(4):624-7 [11992556] Carcinogenesis. 2002 Jul;23(7):1229-34 [12117782] Nucleic Acids Res. 2001 May 1;29(9):1975-81 [11328882] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1513-30 [12496039] Biochemistry. 1985 Jul 30;24(16):4476-81 [4052410] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22 [8367443] Nucleic Acids Res. 2005;33(6):1813-24 [15800211] Oncogene. 2005 Jun 30;24(28):4496-508 [15856018] Exp Cell Res. 2005 Oct 15;310(1):186-95 [16122734] Am J Epidemiol. 2005 Nov 15;162(10):925-42 [16221808] Mutat Res. 2005 Dec 11;591(1-2):60-73 [16081110] Carcinogenesis. 2006 Mar;27(3):560-7 [16195237] Cancer Res. 2002 Dec 15;62(24):7230-3 [12499263] Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):170-1 [12582029] Cancer Res. 2003 Mar 1;63(5):902-5 [12615700] World J Gastroenterol. 2003 May;9(5):956-60 [12717837] Breast Cancer Res Treat. 2003 May;79(1):59-62 [12779082] J Radiat Res. 2003 Mar;44(1):31-5 [12841596] J Natl Cancer Inst. 2003 Sep 3;95(17):1312-9 [12953085] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10670-5 [12960370] J Biol Chem. 2003 Nov 7;278(45):44068-74 [12933815] J Urol. 2003 Dec;170(6 Pt 1):2471-4 [14634453] Biol Pharm Bull. 2004 Apr;27(4):480-5 [15056851] Pharmacogenetics. 2004 Feb;14(2):103-9 [15077011] Cancer Res. 2004 May 1;64(9):3096-102 [15126346] Eye (Lond). 2004 Jun;18(6):635-9 [14716324] Cancer Res. 2004 Jul 1;64(13):4411-4 [15231648] Carcinogenesis. 2004 Aug;25(8):1359-70 [15044326] Carcinogenesis. 2004 Sep;25(9):1689-94 [15073047] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1680-1 [15466987] Mutat Res. 2004 Nov 22;556(1-2):169-81 [15491645] Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5 [10557315] Nature. 2000 Feb 24;403(6772):859-66 [10706276] Cancer Epidemiol Biomarkers Prev. 1999 Aug;8(8):669-74 [10744126] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61 [10725358] Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8397-402 [10890888] Cancer Res. 2000 Sep 1;60(17):4740-4 [10987279] Int J Cancer. 2000 Dec 15;88(6):932-7 [11093817] Nucleic Acids Res. 2001 Jan 15;29(2):430-8 [11139613] Eur J Cancer. 2001 Feb;37(3):340-6 [11239755] Nucleic Acids Res. 2001 Mar 15;29(6):1285-92 [11238994] Mutat Res. 2001 Jun 5;486(1):31-40 [11356334] Cancer Res. 2001 Jul 15;61(14):5378-81 [11454679] J Am Chem Soc. 2001 Jan 17;123(2):359-60 [11456534] Mutat Res. 2001 Aug 9;486(3):207-16 [11459633] Carcinogenesis. 2001 Sep;22(9):1355-62 [11532855] Prog Nucleic Acid Res Mol Biol. 2001;68:193-205 [11554297] Cancer Res. 2002 Mar 1;62(5):1349-55 [11888904] J Biol Chem. 1994 Dec 30;269(52):32709-12 [7806489] Biochemistry. 1995 Jan 24;34(3):737-42 [7827031] Cancer Res. 1997 Jun 1;57(11):2151-6 [9187114] Oncogene. 1997 Jun 12;14(23):2857-61 [9190902] Curr Biol. 1997 Jun 1;7(6):397-407 [9197244] Rev Physiol Biochem Pharmacol. 1997;131:1-87 [9204689] Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7429-34 [9207108] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8010-5 [9223305] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8016-20 [9223306] EMBO J. 1997 Oct 15;16(20):6314-22 [9321410] Oncogene. 1998 Jun 25;16(25):3219-25 [9681819] Jpn J Cancer Res. 1998 Jul;89(7):691-5 [9738974] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation. AN - 67763571; 16546942 AB - Mutations in both p53 and BRCA2 are commonly seen together in human tumors suggesting that the loss of both genes enhances tumor development. To elucidate this interaction in an animal model, mice lacking the carboxy terminal domain of Brca2 were crossed with p53 heterozygous mice. Females from this intercross were then irradiated with an acute dose of 5 Gy ionizing radiation at 5 weeks of age and compared to nonirradiated controls. We found decreased survival and timing of tumor onsets, and significantly higher overall tumor incidences and prevalence of particular tumors, including stomach tumors and squamous cell carcinomas, associated with the homozygous loss of Brca2, independent of p53 status. The addition of a p53 mutation had a further impact on overall survival, incidence of osteosarcomas and stomach tumors, and tumor latency. The spectrum of tumors observed for this Brca2 germline mouse model suggest that it faithfully recapitulates some human disease phenotypes associated with BRCA2 loss. In addition, these findings include extensive in vivo data demonstrating that germline Brca2 and p53 mutations cooperatively affect animal survivals, tumor susceptibilities, and tumor onsets. JF - Toxicologic pathology AU - McAllister, Kimberly A AU - Houle, Christopher D AU - Malphurs, Jason AU - Ward, Toni AU - Collins, N Keith AU - Gersch, William AU - Wharey, Laura AU - Seely, John C AU - Betz, Laura AU - Bennett, L Michelle AU - Wiseman, Roger W AU - Davis, Barbara J AD - National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27711, USA. mcallis2@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 187 EP - 198 VL - 34 IS - 2 SN - 0192-6233, 0192-6233 KW - BRCA2 Protein KW - 0 KW - BRCA2 protein, mouse KW - Index Medicus KW - Animals KW - Bone Neoplasms -- physiopathology KW - Mice KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Genotype KW - Mice, Mutant Strains KW - Survival Rate KW - Stomach Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- physiopathology KW - Carcinoma, Squamous Cell -- genetics KW - Mice, Inbred C57BL KW - Osteosarcoma -- genetics KW - Stomach Neoplasms -- physiopathology KW - Osteosarcoma -- physiopathology KW - Genetic Predisposition to Disease KW - Time Factors KW - Bone Neoplasms -- genetics KW - Female KW - BRCA2 Protein -- physiology KW - Genes, p53 KW - Neoplasms -- physiopathology KW - Neoplasms, Radiation-Induced -- genetics KW - Germ-Line Mutation KW - Neoplasms -- genetics KW - BRCA2 Protein -- genetics KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67763571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Spontaneous+and+irradiation-induced+tumor+susceptibility+in+BRCA2+germline+mutant+mice+and+cooperative+effects+with+a+p53+germline+mutation.&rft.au=McAllister%2C+Kimberly+A%3BHoule%2C+Christopher+D%3BMalphurs%2C+Jason%3BWard%2C+Toni%3BCollins%2C+N+Keith%3BGersch%2C+William%3BWharey%2C+Laura%3BSeely%2C+John+C%3BBetz%2C+Laura%3BBennett%2C+L+Michelle%3BWiseman%2C+Roger+W%3BDavis%2C+Barbara+J&rft.aulast=McAllister&rft.aufirst=Kimberly&rft.date=2006-01-01&rft.volume=34&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-24 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents. AN - 67757383; 16543755 AB - Acute renal failure (ARF) induced by sepsis has a high mortality but lacks effective treatments. To develop novel therapies we must diagnose renal injury early and accurately in septic patients and identify any additional insults such as nephrotoxic drugs and ischemia. In this short review we describe our experience using MRI with dendrimer-based contrast agents in mouse models of ARF. This technique can diagnose early renal injury before serum creatinine is elevated, distinguish different ARF etiologies, track drug therapy and predict outcome. As an ARF biomarker, MRI with dendrimer-based contrast is a promising technique deserving further development. Copyright 2006 S. Karger AG, Basel. JF - Nephron. Clinical practice AU - Dear, James W AU - Kobayashi, Hisataka AU - Brechbiel, Martin W AU - Star, Robert A AD - Renal Diagnostics and Therapeutics Unit, NIDDK, Bethesda, Md 20892-1268, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - c45 EP - c49 VL - 103 IS - 2 KW - Biocompatible Materials KW - 0 KW - Contrast Media KW - Dendrimers KW - PAMAM Starburst KW - Polyamines KW - Index Medicus KW - Animals KW - Mice KW - Magnetic Resonance Imaging KW - Acute Kidney Injury -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67757383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron.+Clinical+practice&rft.atitle=Imaging+acute+renal+failure+with+polyamine+dendrimer-based+MRI+contrast+agents.&rft.au=Dear%2C+James+W%3BKobayashi%2C+Hisataka%3BBrechbiel%2C+Martin+W%3BStar%2C+Robert+A&rft.aulast=Dear&rft.aufirst=James&rft.date=2006-01-01&rft.volume=103&rft.issue=2&rft.spage=c45&rft.isbn=&rft.btitle=&rft.title=Nephron.+Clinical+practice&rft.issn=1660-2110&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons. AN - 67739801; 16458435 AB - Neurons containing tuberoinfundibular peptide of 39 residues (TIP39) constitute a rostro-caudally elongated group of cells in the posterior thalamus. These neurons are located in the rostral part of the subparafascicular nucleus and in the subparafascicular area, caudally. Projections of the caudally located TIP39 neurons have been previously identified by their disappearance following lesions. We have now mapped the projections of the rat rostral subparafascicular neurons using injections of the anterograde tracer biotinylated dextran amine and the retrograde tracer cholera toxin B subunit, and confirmed the projections from more caudal areas previously inferred from lesion studies. Neurons from both the rostral subparafascicular nucleus and the subparafascicular area project to the medial prefrontal, insular, ecto- and perirhinal cortex, nucleus of the diagonal band, septum, central and basomedial amygdaloid nuclei, fundus striati, basal forebrain, midline and intralaminar thalamic nuclei, hypothalamus, subthalamus and the periaqueductal gray. The subparafascicular area projects more densely to the amygdala and the hypothalamus. In contrast, only the rostral part of the subparafascicular nucleus projects significantly to the superficial layers of prefrontal, insular, ectorhinal and somatosensory cortical areas. Double labeling showed that anterogradely labeled fibers from the rostral part of the subparafascicular nucleus contain TIP39 in many forebrain areas, but do not in hypothalamic areas. Injections of the retrograde tracer cholera toxin B subunit into the lateral septum and the fundus striati confirmed that they were indeed target regions of both the rostral subparafascicular nucleus and the subparafascicular area. In contrast, TIP39 neurons did not project to the anterior hypothalamic nucleus. Our data provide an anatomical basis for the potential involvement of rostral subparafascicular neurons in limbic and autonomic regulation, with TIP39 cells being major subparafascicular output neurons projecting to forebrain regions. JF - Neuroscience AU - Wang, J AU - Palkovits, M AU - Usdin, T B AU - Dobolyi, A AD - Laboratory of Genetics, National Institute of Mental Health, Building 35, Room 1B215, 35 Convent Drive, Bethesda, MD 20892-3728, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 1245 EP - 1263 VL - 138 IS - 4 SN - 0306-4522, 0306-4522 KW - Dextrans KW - 0 KW - Neuropeptides KW - biotinylated dextran amine KW - tuberoinfundibular peptide 39 KW - Biotin KW - 6SO6U10H04 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Presynaptic Terminals -- ultrastructure KW - Animals KW - Diencephalon -- metabolism KW - Telencephalon -- metabolism KW - Biotin -- analogs & derivatives KW - Limbic System -- physiology KW - Presynaptic Terminals -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Brain Mapping KW - Autonomic Nervous System -- anatomy & histology KW - Autonomic Nervous System -- physiology KW - Diencephalon -- anatomy & histology KW - Limbic System -- anatomy & histology KW - Telencephalon -- anatomy & histology KW - Male KW - Neuropeptides -- metabolism KW - Prosencephalon -- anatomy & histology KW - Neurons -- metabolism KW - Prosencephalon -- metabolism KW - Posterior Thalamic Nuclei -- metabolism KW - Neural Pathways -- metabolism KW - Neurons -- cytology KW - Neural Pathways -- anatomy & histology KW - Posterior Thalamic Nuclei -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67739801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Forebrain+projections+of+tuberoinfundibular+peptide+of+39+residues+%28TIP39%29-containing+subparafascicular+neurons.&rft.au=Wang%2C+J%3BPalkovits%2C+M%3BUsdin%2C+T+B%3BDobolyi%2C+A&rft.aulast=Wang&rft.aufirst=J&rft.date=2006-01-01&rft.volume=138&rft.issue=4&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-08 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of urine preservation methods and duration of storage on measured levels of environmental contaminants. AN - 67725835; 16007114 AB - Collection of urine samples in human studies involves choices regarding shipping, sample preservation, and storage that may ultimately influence future analysis. As more studies collect and archive urine samples to evaluate environmental exposures in the future, we were interested in assessing the impact of urine preservative, storage temperature, and time since collection on nonpersistent contaminants in urine samples. In spiked urine samples stored in three types of urine vacutainers (no preservative, boric acid, and chlorhexidine), we measured five groups of contaminants to assess the levels of these analytes at five time points (0, 24, 48, and 72 h, and 1 week) and at two temperatures (room temperature and 4 degrees C). The target chemicals were bisphenol A (BPA), metabolites of organophosphate (OP), carbamate, and pyrethroid insecticides, chlorinated phenols, and phthalate monoesters, and were measured using five different mass spectrometry-based methods. Three samples were analyzed at each time point, with the exception of BPA. Repeated measures analysis of variance was used to evaluate effects of storage time, temperature, and preservative. Stability was summarized with percent change in mean concentration from time 0. In general, most analytes were stable under all conditions with changes in mean concentration over time, temperature, and preservative being generally less than 20%, with the exception of the OP metabolites in the presence of boric acid. The effect of storage temperature was less important than time since collection. The precision of the laboratory measurements was high allowing us to observe small differences, which may not be important when categorizing individuals into broader exposure groups. JF - Journal of exposure science & environmental epidemiology AU - Hoppin, Jane A AU - Ulmer, Ross AU - Calafat, Antonia M AU - Barr, Dana B AU - Baker, Susan V AU - Meltzer, Helle M AU - Rønningen, Kjersti S AD - Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, NC, USA. hoppin1@niehs.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 39 EP - 48 VL - 16 IS - 1 SN - 1559-0631, 1559-0631 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Urinalysis -- methods KW - Mass Spectrometry KW - Reproducibility of Results KW - Humans KW - Temperature KW - Specimen Handling KW - Time Factors KW - Environmental Exposure KW - Environmental Pollutants -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67725835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Impact+of+urine+preservation+methods+and+duration+of+storage+on+measured+levels+of+environmental+contaminants.&rft.au=Hoppin%2C+Jane+A%3BUlmer%2C+Ross%3BCalafat%2C+Antonia+M%3BBarr%2C+Dana+B%3BBaker%2C+Susan+V%3BMeltzer%2C+Helle+M%3BR%C3%B8nningen%2C+Kjersti+S&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=15590631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice. AN - 67705993; 16352919 AB - This study presents a mouse model for human age-related macular degeneration (AMD) as characterized by subretinal deposit and choroidal neovascularization. Matrigel, a basement membrane extract, solidifies after implantation in tissue and can stimulate local angiogenesis. This study demonstrates the induction of neovascularization and focal retinal degeneration following subretinal Matrigel injection in mice. In senescent mice, the normal functioning of CC chemokine CCL2/MCP-1 and its receptor CCR2 confers protection against age-related retinal degeneration, a disease that shares many similar features with human AMD. Our data shows that CCL2-deficient mice develop more severe disease as compared to the wild-type controls. These findings suggest that Matrigel subretinal injection could be used to generate AMD-like pathological changes. The data support the previously proposed role of CCL2 in AMD pathogenesis. JF - Ophthalmic research AU - Shen, Defen AU - Wen, Rong AU - Tuo, Jingsheng AU - Bojanowski, Christine M AU - Chan, Chi-Chao AD - Laboratory of Immunology, NEI/NIH, Bethesda, MD 20892-1857, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 71 EP - 73 VL - 38 IS - 2 SN - 0030-3747, 0030-3747 KW - Biocompatible Materials KW - 0 KW - Ccl2 protein, mouse KW - Chemokine CCL2 KW - Drug Combinations KW - Laminin KW - Proteoglycans KW - matrigel KW - 119978-18-6 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Severity of Illness Index KW - Chemokine CCL2 -- deficiency KW - Animals KW - Retina KW - Extracellular Matrix KW - Disease Models, Animal KW - Mice KW - Injections KW - Choroidal Neovascularization -- complications KW - Collagen -- administration & dosage KW - Biocompatible Materials -- toxicity KW - Laminin -- administration & dosage KW - Retinal Degeneration -- complications KW - Biocompatible Materials -- administration & dosage KW - Laminin -- toxicity KW - Proteoglycans -- toxicity KW - Choroidal Neovascularization -- pathology KW - Choroidal Neovascularization -- chemically induced KW - Collagen -- toxicity KW - Proteoglycans -- administration & dosage KW - Retinal Degeneration -- pathology KW - Retinal Degeneration -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67705993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ophthalmic+research&rft.atitle=Exacerbation+of+retinal+degeneration+and+choroidal+neovascularization+induced+by+subretinal+injection+of+Matrigel+in+CCL2%2FMCP-1-deficient+mice.&rft.au=Shen%2C+Defen%3BWen%2C+Rong%3BTuo%2C+Jingsheng%3BBojanowski%2C+Christine+M%3BChan%2C+Chi-Chao&rft.aulast=Shen&rft.aufirst=Defen&rft.date=2006-01-01&rft.volume=38&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Ophthalmic+research&rft.issn=00303747&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Surv Ophthalmol. 2003 May-Jun;48(3):257-93 [12745003] Angiogenesis. 2002;5(1-2):75-80 [12549862] Arch Ophthalmol. 2004 Apr;122(4):598-614 [15078679] Int J Dev Biol. 2004;48(5-6):563-71 [15349831] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13850-5 [15365174] Trans Am Ophthalmol Soc. 1979;77:707-45 [94717] Lab Invest. 1992 Oct;67(4):519-28 [1279270] Am J Pathol. 1997 Jul;151(1):13-23 [9212726] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12053-8 [9342361] Prog Retin Eye Res. 2005 Mar;24(2):275-306 [15610977] Invest Ophthalmol Vis Sci. 2005 Feb;46(2):683-91 [15671300] Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4164-9 [15749821] Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3582-9 [11006256] Arch Ophthalmol. 2001 Nov;119(11):1643-9 [11709015] Drugs Aging. 2002;19(2):101-33 [11950377] Invest Ophthalmol Vis Sci. 2002 May;43(5):1493-8 [11980865] Nat Med. 2003 Nov;9(11):1390-7 [14566334] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. AN - 67699874; 16357512 AB - To determine the maximum-tolerated dose (MTD) and toxicity profile of the novel anticancer agent, 2-methoxyestradiol (2ME2) administered orally, in patients with solid tumors. Twenty patients with refractory solid tumors were enrolled. 2ME2 was given orally starting at 400 mg bid with dose escalation until 3000 mg bid. Tumor biopsies were taken before and after starting the drug to assess for microvessel density by CD 31 and cell proliferation by Ki67 immunohistochemistry. Serial plasma samples collected up to 50 hours after first single oral dose for characterization of pharmacokinetics, were analyzed using liquid chromatography tandem mass-spectrometry. Eleven men and nine women received 2ME2 at dose levels of 400 mg bid (n = 3), 800 mg bid (n = 3), 1600 mg bid (n = 6), 2200 mg bid (n = 5) and 3000 mg bid (n = 3). There were no dose limiting toxicities, therefore the MTD was not defined. There was one episode of grade 4 angioedema in the 1600 mg bid dose level 38 days into 2ME2 treatment. Other toxicities were mild to moderate. A patient with clear cell carcinoma of the ovary had a partial response at 1600 mg bid dose level lasting over three years. MTD for 2ME2 was not reached at dose of 3000 mg bid. The trial was closed due to extremely low plasma concentrations of 2ME2 relative to the doses administered. 2ME2 treatment had no effect on microvessel density (CD31 immunostaining) and cell proliferation (Ki-67 immunostaining). A new formulation of 2ME2 with improved bioavailability is currently being developed. JF - Cancer biology & therapy AU - Dahut, William L AU - Lakhani, Nehal J AU - Gulley, James L AU - Arlen, Philip M AU - Kohn, Elise C AU - Kotz, Herbert AU - McNally, Debbie AU - Parr, Allyson AU - Nguyen, Diana AU - Yang, Sherry X AU - Steinberg, Seth M AU - Venitz, Jürgen AU - Sparreboom, Alex AU - Figg, William D AD - Medical Oncology Clinical Research Unit, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 22 EP - 27 VL - 5 IS - 1 SN - 1538-4047, 1538-4047 KW - Angiogenesis Inhibitors KW - 0 KW - Antineoplastic Agents KW - Estradiol KW - 4TI98Z838E KW - 2-methoxyestradiol KW - 6I2QW73SR5 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Administration, Oral KW - Apoptosis KW - Humans KW - Capillaries -- drug effects KW - Adult KW - Tomography, X-Ray Computed KW - Middle Aged KW - Male KW - Female KW - Estradiol -- analogs & derivatives KW - Estradiol -- adverse effects KW - Angiogenesis Inhibitors -- therapeutic use KW - Neoplasms -- drug therapy KW - Estradiol -- blood KW - Neoplasms -- diagnostic imaging KW - Estradiol -- therapeutic use KW - Maximum Tolerated Dose KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67699874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Phase+I+clinical+trial+of+oral+2-methoxyestradiol%2C+an+antiangiogenic+and+apoptotic+agent%2C+in+patients+with+solid+tumors.&rft.au=Dahut%2C+William+L%3BLakhani%2C+Nehal+J%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BKohn%2C+Elise+C%3BKotz%2C+Herbert%3BMcNally%2C+Debbie%3BParr%2C+Allyson%3BNguyen%2C+Diana%3BYang%2C+Sherry+X%3BSteinberg%2C+Seth+M%3BVenitz%2C+J%C3%BCrgen%3BSparreboom%2C+Alex%3BFigg%2C+William+D&rft.aulast=Dahut&rft.aufirst=William&rft.date=2006-01-01&rft.volume=5&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-23 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of patients with HIV in the intensive care unit. AN - 67686409; 16493156 AB - Because there are more than one million Americans with HIV, intensive care units continue to see frequent patients with HIV infection. In the era of highly active antiretroviral therapy, clinicians must be aware of drug toxicities and drug interactions. They must also recognize traditional opportunistic infections, as well as newer syndromes such as immune reconstitution syndrome, multicentric Castleman's disease, and primary pleural cell lymphoma. JF - Proceedings of the American Thoracic Society AU - Masur, Henry AD - Chief, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. hmasur@cc.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 96 EP - 102 VL - 3 IS - 1 SN - 1546-3222, 1546-3222 KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Treatment Outcome KW - HIV Infections -- therapy KW - Intensive Care Units KW - HIV KW - HIV Infections -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67686409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+American+Thoracic+Society&rft.atitle=Management+of+patients+with+HIV+in+the+intensive+care+unit.&rft.au=Masur%2C+Henry&rft.aulast=Masur&rft.aufirst=Henry&rft.date=2006-01-01&rft.volume=3&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+American+Thoracic+Society&rft.issn=15463222&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-03 N1 - Date created - 2006-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Thorax. 1994 Oct;49(10):958-60 [7526480] JAMA. 1995 Mar 15;273(11):848 [7869553] Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1385-90 [8616570] Lung. 2004;182(6):331-41 [15765925] Blood. 2005 Jan 15;105(2):874-8 [15388574] J Natl Cancer Inst. 2005 Mar 16;97(6):425-32 [15770006] Exp Hematol. 2005 Apr;33(4):487-94 [15781340] Antivir Ther. 2005;10(3):417-22 [15918332] Am J Respir Crit Care Med. 1997 Jan;155(1):72-80 [9001292] J Clin Invest. 1998 Jan 15;101(2):497-502 [9435323] Chest. 1998 Jan;113(1):154-61 [9440583] N Engl J Med. 1998 Mar 26;338(13):853-60 [9516219] Am J Respir Crit Care Med. 1998 Jul;158(1):157-61 [9655723] Chest. 1998 Jul;114(1):251-62 [9674477] Ann Intern Med. 1999 Apr 6;130(7):570-7 [10189326] Br J Dermatol. 1999 May;140(5):875-81 [10354025] AIDS. 1999 May 7;13(7):839-43 [10357384] AIDS. 1999 May 28;13(8):999-1000 [10371187] AIDS. 1999 Jul 30;13(11):1419-20 [10449301] AIDS. 2005 Mar 4;19(4):399-406 [15750393] Lancet. 1999 Oct 16;354(9187):1347-51 [10533864] Chest. 1999 Nov;116(5):1282-6 [10559088] AJR Am J Roentgenol. 2000 Jan;174(1):43-9 [10628452] Int J STD AIDS. 1999 Dec;10(12):795-802 [10639060] Chest. 2000 Apr;117(4):1128-45 [10767252] Blood. 2000 Sep 15;96(6):2069-73 [10979949] AIDS. 2000 Aug 18;14(12):1675-88 [10985303] Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):865-72 [10988097] AIDS. 2000 Dec 1;14(17):2723-30 [11125891] J Clin Oncol. 2001 Apr 15;19(8):2171-8 [11304769] Am J Respir Crit Care Med. 2001 Sep 1;164(5):847-51 [11549544] J Clin Oncol. 2001 Sep 15;19(18):3848-51 [11559722] AIDS. 2002 Jan 4;16(1):75-83 [11741165] Arch Intern Med. 2002 Jan 14;162(1):97-9 [11784229] Clin Infect Dis. 2002 Apr 15;34(8):1137-42 [11915004] J Infect Dis. 2002 May 15;185(10):1530-2 [11992293] Medicine (Baltimore). 2002 May;81(3):213-27 [11997718] Am J Respir Crit Care Med. 2002 Jun 15;165(12):1670; author reply 1670 [12070070] Am J Respir Crit Care Med. 2002 Aug 1;166(3):262-7 [12153955] Clin Infect Dis. 2002 Oct 1;35(7):880-2 [12228826] Annu Rev Med. 2003;54:285-303 [12525676] AIDS. 2003 Feb 14;17(3):371-5 [12556691] Blood. 2003 Jun 15;101(12):4653-9 [12609827] Infection. 2005 Jun;33(3):140-7 [15940415] J Clin Oncol. 2005 Jul 1;23(19):4372-80 [15994147] Ann Hematol. 2005 Aug;84(8):551-2 [15800785] Antivir Ther. 2005;10(4):469-77 [16038472] J Acquir Immune Defic Syndr. 2005 Oct 1;40(2):155-60 [16186732] Clin Infect Dis. 2005 Nov 15;41(10):1483-97 [16231262] Am J Respir Crit Care Med. 2005 Nov 15;172(10):1348; author reply 1348-9 [16275740] AIDS. 2006 May 12;20(8):1095-107 [16691060] AIDS. 1996 Jan;10(1):61-7 [8924253] Chest. 1996 Sep;110(3):729-36 [8797419] Int J STD AIDS. 2003 Jul;14(7):478-81 [12869229] J Clin Oncol. 2003 Sep 15;21(18):3447-53 [12972519] J Clin Oncol. 2003 Nov 1;21(21):3948-54 [14581418] N Engl J Med. 2003 Nov 20;349(21):1993-2003 [14627784] J Clin Oncol. 2003 Dec 1;21(23):4423-7 [14581441] Postgrad Med J. 2003 Dec;79(938):691-4 [14707245] MMWR Recomm Rep. 2004 Apr 16;53(RR-4):1-33 [15123984] Chest. 2004 May;125(5):1602-4 [15136363] N Engl J Med. 2004 Jun 10;350(24):2487-98 [15190141] Cancer. 2004 Jun 15;100(12):2644-54 [15197808] Clin Radiol. 2004 Jul;59(7):596-601 [15208065] AIDS. 2004 Aug 20;18(12):1737-40 [15280789] Thorax. 2004 Aug;59(8):704-7 [15282393] Emerg Infect Dis. 2004 Oct;10(10):1721-8 [15504256] Emerg Infect Dis. 2004 Oct;10(10):1760-5 [15504261] Radiology. 1990 May;175(2):341-3 [2326458] Medicine (Baltimore). 1991 Sep;70(5):326-43 [1656164] Chest. 1993 Oct;104(4):1049-53 [8404164] AJR Am J Roentgenol. 1994 Mar;162(3):547-53 [8109494] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nrf2 defends the lung from oxidative stress. AN - 67671496; 16487040 AB - Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-like ECH-associated protein 1 (Keap1), Nrf2 translocates to the nucleus and binds to an antioxidant response element (ARE). Through transcriptional induction of ARE-bearing genes that encode antioxidant-detoxifying proteins, Nrf2 activates cellular rescue pathways against oxidative injury, inflammation/immunity, apoptosis, and carcinogenesis. ARE-driven genes include direct antioxidants (e.g., GPx), thiol metabolism-associated detoxifying enzymes (e.g., GSTs), stress-response genes (e.g., HO-1), and others (e.g., PSMB5). Application of nrf2 germ-line mutant mice elucidated protective roles for Nrf2 in various models of human disorders in the liver, lung, kidney, brain, and circulation. In the lung, deficiency of nrf2 augmented injury caused by bleomycin and environmental oxidants including hyperoxia, diesel exhaust particles, and cigarette smoke. Microarray analyses of lungs from nrf2-deficient and -sufficient mice identified Nrf2-dependent genes that might be critical in pulmonary protection. Observations from these studies highlight the importance of the Nrf2-antioxidant pathway and may provide new therapeutic strategies for acute respiratory distress syndrome, idiopathic pulmonary fibrosis, cancer, and emphysema in which oxidative stress is implicated. JF - Antioxidants & redox signaling AU - Cho, Hye-Youn AU - Reddy, Sekhar P AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. cho2@niehs.nih.gov PY - 2006 SP - 76 EP - 87 VL - 8 IS - 1-2 SN - 1523-0864, 1523-0864 KW - Antioxidants KW - 0 KW - NF-E2-Related Factor 2 KW - Index Medicus KW - Animals KW - Humans KW - Lung Diseases -- prevention & control KW - Protein Transport KW - Oxidative Stress KW - Lung -- physiology KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67671496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Nrf2+defends+the+lung+from+oxidative+stress.&rft.au=Cho%2C+Hye-Youn%3BReddy%2C+Sekhar+P%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2006-01-01&rft.volume=8&rft.issue=1-2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=15230864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2006-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Afferent connections of the subparafascicular area in rat. AN - 67658227; 16361065 AB - The subparafascicular nucleus and the subparafascicular area are the major sites of synthesis of the recently discovered neuropeptide, tuberoinfundibular peptide of 39 residues (TIP39). Better knowledge of the neuronal inputs to the subparafascicular area and nucleus will facilitate investigation of the functions of TIP39. Thus, we have injected the retrograde tracer cholera toxin B subunit into the rostral, middle, and caudal parts of the rat subparafascicular nucleus. We report that the afferent projections to the subparafascicular nucleus and area include the medial prefrontal, insular, and ectorhinal cortex, the subiculum, the lateral septum, the anterior amygdaloid area, the medial amygdaloid nucleus, the caudal paralaminar area of the thalamus, the lateral preoptic area, the anterior, ventromedial, and posterior hypothalamic nuclei, the dorsal premamillary nucleus, the zona incerta and Forel's fields, the periaqueductal gray, the deep layers of the superior colliculus, cortical layers of the inferior colliculus, the cuneiform nucleus, the medial paralemniscal nucleus, and the parabrachial nuclei. Most of these regions project to all parts of the subparafascicular nucleus. However, the magnocellular subparafascicular neurons, which occupy the middle part of the subparafascicular nucleus, may not receive projections from the medial prefrontal and insular cortex, the medial amygdaloid nucleus, the lateral preoptic area, and the parabrachial nuclei. In addition, double labeling of cholera toxin B subunit and TIP39 revealed a remarkable similarity between input regions of the subparafascicular area and the brain TIP39 system. Neurons within regions that contain TIP39 cell bodies as well as regions that contain TIP39 fibers project to the subparafascicular area. Overall, the afferent connections of the subparafascicular nucleus and area suggest its involvement in central reproductive, visceral, nociceptive, and auditory regulation. JF - Neuroscience AU - Wang, J AU - Palkovits, M AU - Usdin, T B AU - Dobolyi, A AD - Laboratory of Genetics, National Institute of Mental Health, 35 Convent Drive, Bethesda, MD 20892-3728, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 197 EP - 220 VL - 138 IS - 1 SN - 0306-4522, 0306-4522 KW - Neuropeptides KW - 0 KW - tuberoinfundibular peptide 39 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Rats KW - Neuropeptides -- metabolism KW - Nerve Fibers -- physiology KW - Animals KW - Rats, Sprague-Dawley KW - Afferent Pathways -- physiology KW - Immunohistochemistry KW - Male KW - Posterior Thalamic Nuclei -- cytology KW - Brain -- cytology KW - Posterior Thalamic Nuclei -- physiology KW - Brain -- physiology KW - Neurons, Afferent -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67658227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Afferent+connections+of+the+subparafascicular+area+in+rat.&rft.au=Wang%2C+J%3BPalkovits%2C+M%3BUsdin%2C+T+B%3BDobolyi%2C+A&rft.aulast=Wang&rft.aufirst=J&rft.date=2006-01-01&rft.volume=10&rft.issue=4&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Justice+Quarterly+%3A+JQ&rft.issn=07418825&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. AN - 67645406; 16467870 AB - Naïve CD4 T cells can differentiate into at least two different types of T helpers, Th1 and Th2 cells. Th2 cells, capable of producing IL-4, IL-5 and IL-13, are involved in humoral immunity against extracellular pathogens and in the induction of asthma and other allergic diseases. In this review, we summarize recent reports regarding the transcription factors involved in Th2 differentiation and cell expansion, including Stat5, Gfi-1 and GATA-3. Stat5 activation is necessary and sufficient for IL-2-mediated function in Th2 differentiation. Enhanced Stat5 signaling induces Th2 differentiation independent of IL-4 signaling; although it does not up-regulate GATA-3 expression, it does require the presence of GATA-3 for its action. Gfi-1, induced by IL-4, promotes the expansion of GATA-3-expressing cells. Analysis of conditional Gata3 knockout mice confirmed the critical role of GATA-3 in Th2 cell differentiation (both IL-4 dependent and IL-4 independent) and in Th2 cell proliferation and also showed the importance of basal GATA-3 expression in inhibiting Th1 differentiation. JF - Cell research AU - Zhu, Jinfang AU - Yamane, Hidehiro AU - Cote-Sierra, Javier AU - Guo, Liying AU - Paul, William E AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. jfzhu@niaid.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 3 EP - 10 VL - 16 IS - 1 SN - 1001-0602, 1001-0602 KW - Cytokines KW - 0 KW - DNA-Binding Proteins KW - GATA3 Transcription Factor KW - Gfi1 protein, mouse KW - Interleukin-2 KW - RNA, Messenger KW - STAT5 Transcription Factor KW - Transcription Factors KW - Interleukin-4 KW - 207137-56-2 KW - Ionomycin KW - 56092-81-0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Transcription Factors -- physiology KW - STAT5 Transcription Factor -- physiology KW - Animals KW - Interleukin-2 -- metabolism KW - Transcription Factors -- metabolism KW - RNA, Messenger -- drug effects KW - Cell Differentiation KW - Ionomycin -- pharmacology KW - Mice KW - Cell Proliferation KW - Models, Biological KW - Transcriptional Activation KW - Mice, Knockout KW - Interleukin-4 -- metabolism KW - RNA, Messenger -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - DNA-Binding Proteins -- physiology KW - Gene Expression Regulation KW - Signal Transduction KW - DNA-Binding Proteins -- metabolism KW - GATA3 Transcription Factor -- physiology KW - Th2 Cells -- physiology KW - Cytokines -- metabolism KW - Th1 Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67645406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+research&rft.atitle=GATA-3+promotes+Th2+responses+through+three+different+mechanisms%3A+induction+of+Th2+cytokine+production%2C+selective+growth+of+Th2+cells+and+inhibition+of+Th1+cell-specific+factors.&rft.au=Zhu%2C+Jinfang%3BYamane%2C+Hidehiro%3BCote-Sierra%2C+Javier%3BGuo%2C+Liying%3BPaul%2C+William+E&rft.aulast=Zhu&rft.aufirst=Jinfang&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Cell+research&rft.issn=10010602&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental health information resources: healthy environments for healthy women and children. AN - 67618553; 16399608 AB - Because of concerns about exposure (e.g., from pesticides in the garden to how much fish is safe to eat), health professionals are often asked to address the effect of environmental agents on women's health. Numerous environmental health resources are available on the Internet, but with so many Web sites, it can be difficult to identify high-quality, accurate information oriented toward a wide variety of needs and users. This article describes environmental health and toxicology databases and resources from the National Library of Medicine (NLM) and other government agencies and organizations, that contain valuable information on potential environmental risks to women. JF - Journal of midwifery & women's health AU - Arnesen, Stacey J AD - Special Projects in the Specialized Information Services Division, National Library of Medicine, Bethesda, MD 20892, USA. stacey_arnesen@nlm.nih.gov PY - 2006 SP - 35 EP - 38 VL - 51 IS - 1 KW - Index Medicus KW - Nursing KW - United States KW - National Library of Medicine (U.S.) KW - Humans KW - Communication KW - Health Education KW - Male KW - Internet KW - Female KW - Pregnancy KW - Lactation KW - Environmental Health KW - Databases as Topic KW - Information Dissemination KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67618553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+midwifery+%26+women%27s+health&rft.atitle=Environmental+health+information+resources%3A+healthy+environments+for+healthy+women+and+children.&rft.au=Arnesen%2C+Stacey+J&rft.aulast=Arnesen&rft.aufirst=Stacey&rft.date=2006-01-01&rft.volume=51&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+midwifery+%26+women%27s+health&rft.issn=1542-2011&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytochrome P450 and xenobiotic receptor humanized mice. AN - 67617267; 16402898 AB - Most xenobiotics that enter the body are subjected to metabolism that functions primarily to facilitate their elimination. Metabolism of certain xenobiotics can also result in the production of electrophilic derivatives that can cause cell toxicity and transformation. Many xenobiotics can also activate receptors that in turn induce the expression of genes encoding xenobiotic-metabolizing enzymes and xenobiotic transporters. However, there are marked species differences in the way mammals respond to xenobiotics, which are due in large part to molecular differences in receptors and xenobiotic-metabolizing enzymes. This presents a problem in extrapolating data obtained with rodent model systems to humans. There are also polymorphisms in xenobiotic-metabolizing enzymes that can impact drug therapy and cancer susceptibility. In an effort to generate more reliable in vivo systems to study and predict human response to xenobiotics, humanized mice are under development. JF - Annual review of pharmacology and toxicology AU - Gonzalez, Frank J AU - Yu, Ai-Ming AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. fjgonz@helix.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 41 EP - 64 VL - 46 SN - 0362-1642, 0362-1642 KW - Receptors, Drug KW - 0 KW - Xenobiotics KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Species Specificity KW - Receptors, Drug -- genetics KW - Receptors, Drug -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Xenobiotics -- metabolism KW - Xenobiotics -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67617267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+pharmacology+and+toxicology&rft.atitle=Cytochrome+P450+and+xenobiotic+receptor+humanized+mice.&rft.au=Gonzalez%2C+Frank+J%3BYu%2C+Ai-Ming&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2006-01-01&rft.volume=46&rft.issue=&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+pharmacology+and+toxicology&rft.issn=03621642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-12 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biochem. 1993 Jan;113(1):7-12 [8454577] FEBS Lett. 1993 Mar 22;319(3):207-11 [8096192] Mol Pharmacol. 1993 Apr;43(4):504-8 [8386305] Pharmacogenetics. 1993 Feb;3(1):51-7 [8387380] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] J Biol Chem. 1993 Jun 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[15649641] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues of aging and geriatric medicine: relevance to cancer treatment and hematopoietic reconstitution. AN - 67617246; 16399593 AB - Aging is not a disease. Nevertheless, diseases, including most malignancies, increase in frequency with advancing age. Although there are many reasons why this might be the case, perhaps most important is that it takes time to progress through the many steps of carcinogenesis and growth to reach a threshold for diagnosis. Other factors, including accumulated nonlethal damage to DNA (eg, by free radicals), increased proinflammatory factors, and age-associated declines in DNA repair and immune competence, are to some degree important. The median age for all cancer is approximately 70 years and will become even older over the next several decades. Myelodysplasia and hematologic malignancies, including lymphoma, myeloma, and leukemia, can be effectively treated in older age groups, but advanced age presents a number of additional challenges. With appropriate pretreatment assessment of organ reserve, physical performance, and cognitive function, individualized (tailored) therapy may ultimately prove to offer the greatest chance for successful outcomes. Such assessment would also identify those who are likely to benefit from more aggressive treatments, including bone marrow or stem cell transplantation. JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Ershler, William B AU - Artz, Andrew S AU - Keller, Evan T AD - Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA. wershler@iasia.org Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 100 EP - 106 VL - 12 IS - 1 Suppl 1 SN - 1083-8791, 1083-8791 KW - Index Medicus KW - Inflammation -- therapy KW - Disease-Free Survival KW - DNA Damage KW - Aged, 80 and over KW - Humans KW - Treatment Outcome KW - Aged KW - Remission Induction -- methods KW - Inflammation -- mortality KW - Male KW - Female KW - Inflammation -- pathology KW - Hematologic Neoplasms -- therapy KW - Hematologic Neoplasms -- pathology KW - Bone Marrow Transplantation -- methods KW - Geriatrics -- trends KW - Geriatrics -- methods KW - Bone Marrow Transplantation -- trends KW - Recovery of Function KW - Aging -- pathology KW - Hematopoiesis KW - Hematologic Neoplasms -- mortality KW - Bone Marrow Transplantation -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67617246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Issues+of+aging+and+geriatric+medicine%3A+relevance+to+cancer+treatment+and+hematopoietic+reconstitution.&rft.au=Ershler%2C+William+B%3BArtz%2C+Andrew+S%3BKeller%2C+Evan+T&rft.aulast=Ershler&rft.aufirst=William&rft.date=2006-01-01&rft.volume=12&rft.issue=1+Suppl+1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=10838791&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen. AN - 67610536; 16193534 AB - 1,4-Butanediol is an industrial chemical used primarily as an intermediate in the manufacture of other organic chemicals. It has recently been associated with deaths, addiction and withdrawal related to its promotion and use as a dietary supplement. The rapid absorption and conversion of 1,4-butanediol to gamma-hydroxybutyric acid (GHB, or date rape drug) in animals and humans is well documented and is the basis for its abuse potential. A disposition and metabolism study conducted in F344 rats by the National Toxicology Program (NTP) confirmed the rapid conversion of 1-(14)C-1,4-butanediol to (14)CO2. Because of this, the toxicological profile of 1,4-butanediol resembles that of gamma-hydroxybutyric acid. Gamma-hydroxybutyric acid occurs naturally in the brain and peripheral tissues and is converted to succinate and metabolized through the TCA cycle. Although the function of gamma-hydroxybutyric acid in peripheral tissues is not known, the presence of specific high affinity receptors for gamma-hydroxybutyric acid suggests that it functions as a neuromodulator in the brain and neuronal tissue. Gamma-hydroxybutyric acid readily crosses the blood-brain barrier and elicits characteristic neuropharmacologic responses after oral, i.p., or i.v. administration. The same responses are observed after administration of 1,4-butanediol. The cyclic lactone of gamma-hydroxybutyric acid, gamma-butyrolactone, is also rapidly converted to gamma-hydroxybutyric acid by enzymes in the blood and liver in animals and humans, and produces pharmacological effects identical to those produced by 1,4-butanediol and gamma-hydroxybutyric acid. Gamma-butyrolactone was previously evaluated by the NTP in 14-day and 13-week prechronic toxicology studies and in 2-year chronic toxicology and carcinogenesis studies in F344 rats and B6C3F1 mice. No organ specific toxicity occurred. In the carcinogenesis studies there was an equivocal response in male mice based on a marginal increase in the incidence of pheochromocytomas of the adrenal medulla. Because the absence of chronic toxicity and significant carcinogenicity of gamma-hydroxybutyric acid were established in NTP prechronic and chronic studies with gamma-butyrolactone, it is concluded that similar results would be obtained in a 2-year study with 1,4-butanediol, and that 1,4-butanediol is not a carcinogen. 2005 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Irwin, Richard D AD - National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. irwin@niehs.nih.gov PY - 2006 SP - 72 EP - 80 VL - 26 IS - 1 SN - 0260-437X, 0260-437X KW - Butylene Glycols KW - 0 KW - Hydroxybutyrates KW - Solvents KW - 4-hydroxybutyric acid KW - 30IW36W5B2 KW - 1,4-butanediol KW - 7XOO2LE6G3 KW - 4-Butyrolactone KW - OL659KIY4X KW - Index Medicus KW - Animals KW - Solvents -- toxicity KW - 4-Butyrolactone -- toxicity KW - Hydroxybutyrates -- toxicity KW - Biotransformation KW - Humans KW - Hydroxybutyrates -- metabolism KW - Carcinogenicity Tests KW - Butylene Glycols -- toxicity KW - Butylene Glycols -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67610536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=A+review+of+evidence+leading+to+the+prediction+that+1%2C4-butanediol+is+not+a+carcinogen.&rft.au=Irwin%2C+Richard+D&rft.aulast=Irwin&rft.aufirst=Richard&rft.date=2006-01-01&rft.volume=26&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. AN - 67609683; 16400030 AB - We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrine/paracrine tumor cell survival factor. We now present evidence that AM is an important regulator of mast cell (MC) function and that this modulation is potentially involved in tumor promotion. AM induced histamine or beta-hexosaminidase release from rat and human MCs through a receptor-independent pathway. AM was chemotactic for human MCs and stimulated mRNA expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and basic fibroblast growth factor in this cell type. Differentiated but not undifferentiated human MCs responded to hypoxic insult with elevated AM mRNA/protein expression. Using confocal microscopy, we identified AM-producing MCs in tumor infiltrates of human breast and lung cancer patients. In mixed culture assays the AM-producing human MC line HMC-1 augmented both anchorage-dependent and -independent growth of human lung cancer A549 cells, an effect that was suppressed by MC-targeted siRNA AM knockdown. Finally, HMC-1 cells induced in vivo angiogenesis as assessed by directed in vivo angiogenesis assay analysis; neutralizing anti-AM monoclonal antibody blocked this ability. Our collective data suggest a new role for AM as a cross-talk molecule that integrates tumor and MC communication, underlying a unique promotion mechanism of human cancers. JF - The American journal of pathology AU - Zudaire, Enrique AU - Martínez, Alfredo AU - Garayoa, Mercedes AU - Pío, Rubén AU - Kaur, Gurmeet AU - Woolhiser, Michael R AU - Metcalfe, Dean D AU - Hook, William A AU - Siraganian, Reuben P AU - Guise, Theresa A AU - Chirgwin, John M AU - Cuttitta, Frank AD - CCBB, CCR, National Cancer Institute, Bldg. 10, Rm., 12N226, Bethesda, MD 20892, USA. zudairee@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 280 EP - 291 VL - 168 IS - 1 SN - 0002-9440, 0002-9440 KW - Chemokine CCL2 KW - 0 KW - Peptides KW - RNA, Messenger KW - Vascular Endothelial Growth Factor A KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Adrenomedullin KW - 148498-78-6 KW - Abridged Index Medicus KW - Index Medicus KW - Fibroblast Growth Factor 2 -- biosynthesis KW - Microscopy, Confocal KW - Animals KW - Vascular Endothelial Growth Factor A -- biosynthesis KW - Humans KW - Neovascularization, Pathologic -- metabolism KW - RNA, Messenger -- analysis KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - Chemokine CCL2 -- metabolism KW - Chemotaxis, Leukocyte -- physiology KW - Rats KW - Receptor Cross-Talk -- physiology KW - Mast Cells -- metabolism KW - Peptides -- metabolism KW - Cell Communication -- physiology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67609683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Adrenomedullin+is+a+cross-talk+molecule+that+regulates+tumor+and+mast+cell+function+during+human+carcinogenesis.&rft.au=Zudaire%2C+Enrique%3BMart%C3%ADnez%2C+Alfredo%3BGarayoa%2C+Mercedes%3BP%C3%ADo%2C+Rub%C3%A9n%3BKaur%2C+Gurmeet%3BWoolhiser%2C+Michael+R%3BMetcalfe%2C+Dean+D%3BHook%2C+William+A%3BSiraganian%2C+Reuben+P%3BGuise%2C+Theresa+A%3BChirgwin%2C+John+M%3BCuttitta%2C+Frank&rft.aulast=Zudaire&rft.aufirst=Enrique&rft.date=2006-01-01&rft.volume=168&rft.issue=1&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1988 Jul 15;42(1):48-52 [2455691] Leuk Res. 1988;12(4):345-55 [3131594] J Cancer Res Clin Oncol. 1991;117(2):115-22 [1901064] Br J Cancer. 1991 Jun;63(6):873-8 [2069844] Basic Life Sci. 1991;57:43-57; discussion 57-9 [1667574] Biochem Biophys Res Commun. 1993 Apr 30;192(2):553-60 [8387282] Trends Genet. 1993 Apr;9(4):138-41 [8516849] Scand J Immunol. 1994 May;39(5):489-98 [8191224] Endocrinology. 1995 Sep;136(9):4099-105 [7649118] Invasion Metastasis. 1994-1995;14(1-6):395-408 [7544776] Blood. 1995 Oct 1;86(7):2488-93 [7545457] Endocrinology. 1996 Jun;137(6):2626-32 [8641217] J Biol Chem. 1996 Sep 20;271(38):23345-51 [8798536] Physiol Rev. 1997 Oct;77(4):1033-79 [9354811] Oncogene. 1998 Jan 22;16(3):409-15 [9467966] Cancer Res. 1998 Apr 1;58(7):1408-16 [9537241] Nature. 1998 May 28;393(6683):333-9 [9620797] J Gen Physiol. 1998 Nov;112(5):577-91 [9806967] Exp Dermatol. 1999 Feb;8(1):1-16 [10206716] Genes Dev. 1999 Jun 1;13(11):1382-97 [10364156] Endocrinology. 2005 Mar;146(3):1321-7 [15576460] Microsc Res Tech. 2002 Apr 15;57(2):110-9 [11921362] Am J Pathol. 2002 Apr;160(4):1279-92 [11943713] Oncogene. 2002 Apr 25;21(18):2815-21 [11973640] APMIS. 2002 May;110(5):355-71 [12076253] J Natl Cancer Inst. 2002 Aug 21;94(16):1226-37 [12189226] Br J Haematol. 2002 Oct;119(1):122-4 [12358914] Int Rev Cytol. 2002;221:1-92 [12455746] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Endocrinol. 2000 Jun;14(6):848-62 [10847587] Cancer. 2000 Jun 15;88(12):2686-92 [10870050] Blood. 2000 Jul 1;96(1):34-40 [10891427] Mol Hum Reprod. 2000 Oct;6(10):867-72 [11006313] Cancer Res. 2001 Feb 1;61(3):1196-206 [11221851] J Biol Chem. 2001 Apr 13;276(15):12292-300 [11116141] Oncogene. 2001 May 24;20(23):2937-45 [11420706] Regul Pept. 2001 Sep 15;101(1-3):163-8 [11495692] Br J Cancer. 2001 Aug 17;85(4):473-83 [11506482] Front Biosci. 2001 Sep 1;6:D1109-27 [11532608] J Clin Pathol. 2001 Dec;54(12):940-4 [11729214] Br J Haematol. 2001 Dec;115(3):514-21 [11736931] Oncology (Williston Park). 2002 Feb;16(2):217-26, 229; discussion 230-2 [11866137] Eur J Pharmacol. 2003 Mar 19;464(2-3):111-4 [12620502] Am J Pathol. 2003 May;162(5):1431-9 [12707026] Eur J Clin Invest. 2003 May;33(5):420-5 [12760367] Exp Dermatol. 2003 Dec;12(6):886-910 [14719507] Clin Immunol. 2004 Feb;110(2):172-80 [15003814] Trends Immunol. 2004 May;25(5):235-41 [15099563] Endocrinology. 2004 Aug;145(8):3858-65 [15107357] Biochem J. 2004 Nov 1;383(Pt. 3):413-8 [15307819] Int J Cancer. 1988 May 15;41(5):777-8 [3130315] Proc Soc Exp Biol Med. 1990 Jan;193(1):50-5 [1688467] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. AN - 67608377; 16397043 AB - Cancer chemotherapy has been associated with cognitive impairment. Several issues complicate such findings including the patients' health, use of multiple chemotherapeutic agents, and proper assessment of cognition. To control these factors, we conducted cognitive studies in female rats receiving cyclophosphamide or 5-fluorouracil (5FU). Young (7 months) female Fischer-344 rats received five injections of cyclophosphamide (100 mg/kg), 5FU (150 mg/kg), or saline i.p. every 4 weeks for a total of 18 weeks. Aged (18 months) female Fischer-344 rats were treated with cyclophosphamide (80 mg/kg i.p.) for 16 weeks. After 8 to 10 weeks of recovery, rats were tested in two maze learning tasks, the Morris water maze and the Stone 14-unit T-maze. Neuronal synaptic function was assessed by examining long-term potentiation (LTP) in hippocampal slices obtained from young cyclophosphamide-treated rats. Despite the toxic effects induced by chemotherapy, cyclophosphamide- and 5FU-treated rats showed significantly better maze performance compared with controls. Following 29 to 42 weeks of recovery from chemotherapy, no significant effects were observed on maze performance. In aged rats, cyclophosphamide treatment for 14 weeks also produced toxicity, but no impairment in Stone maze learning after 16 weeks of recovery. When assessed during cyclophosphamide treatment, evidence of impaired LTP emerged; however, with 8 weeks of recovery following five cyclophosphamide treatments, we observed enhanced LTP. Despite toxicity accompanying chemotherapy, no evidence of impaired cognitive performance emerged after recovery. Indeed, following 7 to 9 weeks of recovery, we noted evidence of improved learning and LTP. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Lee, Garrick D AU - Longo, Dan L AU - Wang, Yue AU - Rifkind, Joseph M AU - Abdul-Raman, Lilanie AU - Mamczarz, Jacek A AU - Duffy, Kara B AU - Spangler, Edward L AU - Taub, Dennis D AU - Mattson, Mark P AU - Ingram, Donald K AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA. Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 198 EP - 205 VL - 12 IS - 1 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Maze Learning -- drug effects KW - Age Factors KW - Organ Culture Techniques KW - Female KW - Hippocampus -- drug effects KW - Neoplasms -- drug therapy KW - Fluorouracil -- adverse effects KW - Cognition -- drug effects KW - Long-Term Potentiation -- drug effects KW - Cyclophosphamide -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67608377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Transient+improvement+in+cognitive+function+and+synaptic+plasticity+in+rats+following+cancer+chemotherapy.&rft.au=Lee%2C+Garrick+D%3BLongo%2C+Dan+L%3BWang%2C+Yue%3BRifkind%2C+Joseph+M%3BAbdul-Raman%2C+Lilanie%3BMamczarz%2C+Jacek+A%3BDuffy%2C+Kara+B%3BSpangler%2C+Edward+L%3BTaub%2C+Dennis+D%3BMattson%2C+Mark+P%3BIngram%2C+Donald+K&rft.aulast=Lee&rft.aufirst=Garrick&rft.date=2006-01-01&rft.volume=12&rft.issue=1&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2006-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2006 Aug 15;12(16):5000; author reply 5000-1 [16914590] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. AN - 67606888; 16393464 AB - Earlier data showed that men fasted for 38 h had a reduced rate of chlorzoxazone metabolism, suggesting a decreased level of cytochrome P450 2E1 (CYP2E1). In contrast, the level of CYP2E1 in fasted rats had been shown to be elevated. In this study, we have investigated whether chlorzoxazone metabolism in fasted rats was changed by determining the pharmacokinetics of chlorzoxazone and its metabolite, 6-hydroxychlorzoxazone (6-OHCZ), as a CYP2E1 probe, and by measuring liver CYP2E1 using immunoblot techniques. Chlorzoxazone was administered by gavage (50 mg kg(-1)) or intravenously (25 mg kg(-1)) to control (nine for oral and three for intravenous) and 24 h-fasted (nine for oral and four for intravenous) male Sprague-Dawley rats. Following sampling of blood through a jugular vein cannula, chlorzoxazone and 6-OHCZ plasma concentrations were measured by HPLC with UV detection. Pharmacokinetic parameters for chlorzoxazone and 6-OHCZ in each treatment group were determined by model fitting and non-compartmental analysis. In parallel with the increased liver CYP2E1 level, the elimination of chlorzoxazone and 6-OHCZ was significantly increased in fasted rats in the oral and the intravenous study. A multiple analysis of variance covariance analysis and a multiple regression analysis revealed a significant correlation between 1/t(1/2) and CYP2E1 level and aniline hydroxylase activity. However, the correlation between 1/t(1/2) and pentoxyresorufin O-dealkylase, ethoxyresorufin O-dealkylase and erythromycin N-demethylase was not significant. Therefore the contribution of other P450s to chlorzoxazone metabolism seemed to be minor in the concentration range that we tested. In conclusion, fasting rats for 24 h caused a measurable induction of CYP2E1, which produced a significant increase in the rate of chlorzoxazone metabolism and elimination. JF - The Journal of pharmacy and pharmacology AU - Wan, Jie AU - Ernstgård, Lena AU - Song, Byoung J AU - Shoaf, Susan E AD - Laboratory of Clinical Studies, NIAAA, NIH, Bethesda, MD 20892-1256, USA. jwan2@yahoo.com Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 51 EP - 61 VL - 58 IS - 1 SN - 0022-3573, 0022-3573 KW - Muscle Relaxants, Central KW - 0 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aniline Hydroxylase KW - EC 1.14.14.- KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP2B1 KW - Cytochrome P-450 CYP3A KW - Chlorzoxazone KW - H0DE420U8G KW - Index Medicus KW - Administration, Oral KW - Animals KW - Muscle Relaxants, Central -- pharmacokinetics KW - Liver -- enzymology KW - Injections, Intravenous KW - Food-Drug Interactions KW - Cytochrome P-450 CYP2B1 -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Muscle Relaxants, Central -- administration & dosage KW - Cytochrome P-450 CYP3A -- metabolism KW - Aniline Hydroxylase -- metabolism KW - Muscle Relaxants, Central -- blood KW - Male KW - Chlorzoxazone -- blood KW - Chlorzoxazone -- pharmacokinetics KW - Cytochrome P-450 CYP2E1 -- biosynthesis KW - Chlorzoxazone -- administration & dosage KW - Fasting -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67606888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacy+and+pharmacology&rft.atitle=Chlorzoxazone+metabolism+is+increased+in+fasted+Sprague-Dawley+rats.&rft.au=Wan%2C+Jie%3BErnstg%C3%A5rd%2C+Lena%3BSong%2C+Byoung+J%3BShoaf%2C+Susan+E&rft.aulast=Wan&rft.aufirst=Jie&rft.date=2006-01-01&rft.volume=58&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacy+and+pharmacology&rft.issn=00223573&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Life Sci. 1996;58(18):1575-85 [8649187] Chem Biol Interact. 1997 Nov 6;107(1-2):75-91 [9402951] J Hepatol. 1998 Apr;28(4):564-71 [9566824] Xenobiotica. 1998 Jul;28(7):683-98 [9711812] J Biol Chem. 1998 Nov 20;273(47):31581-9 [9813074] Toxicol Sci. 1999 Apr;48(2):189-96 [10353310] Food Chem Toxicol. 1999 Apr;37(4):351-5 [10418953] Biochem Pharmacol. 1999 Aug 1;58(3):461-3 [10424765] Pharmacogenetics. 1999 Jun;9(3):377-88 [10471070] J Pharmacol Exp Ther. 1999 Oct;291(1):213-9 [10490907] J Pharmacol Exp Ther. 1960 Apr;128:340-3 [13811547] Drug Metab Dispos. 1999 Nov;27(11):1274-80 [10534312] Exp Mol Med. 2004 Feb 29;36(1):71-7 [15031674] J Clin Invest. 1979 Apr;63(4):619-26 [438326] Biochem Pharmacol. 1985 Sep 15;34(18):3337-45 [3929792] J Biol Chem. 1986 Dec 15;261(35):16689-97 [3782137] Alcohol Clin Exp Res. 1986;10(6 Suppl):44S-49S [3544930] Biochem Biophys Res Commun. 1987 Feb 13;142(3):1077-83 [3827895] Cancer Res. 1987 Jul 1;47(13):3378-83 [3581075] J Biol Chem. 1989 Feb 25;264(6):3568-72 [2914964] Arch Biochem Biophys. 1989 Jun;271(2):270-83 [2729995] J Pharmacobiodyn. 1990 Jun;13(6):367-73 [2231268] Mol Endocrinol. 1987 Aug;1(8):542-7 [3153476] Drug Metab Rev. 1990;22(2-3):147-59 [2272285] Mol Pharmacol. 1991 Mar;39(3):275-80 [2005876] Chem Res Toxicol. 1990 Nov-Dec;3(6):566-73 [2103328] Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256] Mol Pharmacol. 1992 Mar;41(3):474-9 [1545775] J Chromatogr. 1993 Dec 8;622(1):79-86 [8120116] Clin Pharmacol Ther. 1994 Oct;56(4):359-67 [7955797] Biochem Pharmacol. 1995 May 26;49(11):1665-73 [7786308] Alcohol Clin Exp Res. 1995 Apr;19(2):362-6 [7625570] Drug Metab Dispos. 1995 Mar;23(3):438-40 [7628313] Pharmacogenetics. 1995 Jun;5(3):143-50 [7550365] J Biol Chem. 1995 Dec 15;270(50):29632-5 [8530344] Toxicol Lett. 1995 Nov;81(1):39-44 [8525497] Drug Metab Dispos. 1997 Apr;25(4):502-7 [9107550] Xenobiotica. 1997 Mar;27(3):243-56 [9141232] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic polymorphisms in arginase I and II and childhood asthma and atopy. AN - 67606122; 16387594 AB - A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma. To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk. We enrolled 433 case-parent triads, consisting of patients with asthma 4 to 17 years old and their biologic parents, from the allergy clinic of a public hospital in Mexico City between 1998 and 2003. Atopy to 24 aeroallergens was determined by skin prick tests. We genotyped 4 single nucleotide polymorphisms (SNPs) of ARG1 and 4 SNPs of ARG2 with minor allele frequencies higher than 10% by using the TaqMan assay (Roche Molecular Systems, Pleasanton, Calif). ARG1 SNPs and haplotypes were not associated with asthma, but all 4 ARG1 SNPs were associated with the number of positive skin tests (P = .007-.018). Carrying 2 copies of minor alleles for either of 2 highly associated ARG2 SNPs was associated with a statistically significant increased relative risk (RR) of asthma (1.5, 95% CI = 1.1-2.1 for arg2s1; RR = 1.6, 95% CI = 1.1-2.3 for arg2s2). The association was slightly stronger among children with a smoking parent (arg2s1 RR = 2.1, 95% CI = 1.2 - 3.9 with a smoking parent; RR = 1.2, 95% CI = 0.8-1.9 without; interaction P = .025). Haplotype analyses reduced the sample size but supported the single SNP results. One ARG2 SNP was related to the number of positive skin tests (P = .027). Variation in arginase genes may contribute to asthma and atopy in children. JF - The Journal of allergy and clinical immunology AU - Li, Huiling AU - Romieu, Isabelle AU - Sienra-Monge, Juan-Jose AU - Ramirez-Aguilar, Matiana AU - Estela Del Rio-Navarro, Blanca AU - Kistner, Emily O AU - Gjessing, Håkon K AU - Lara-Sanchez, Irma Del Carmen AU - Chiu, Grace Y AU - London, Stephanie J AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 119 EP - 126 VL - 117 IS - 1 SN - 0091-6749, 0091-6749 KW - Tobacco Smoke Pollution KW - 0 KW - Arginase KW - EC 3.5.3.1 KW - arginase II, human KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Polymorphism, Single Nucleotide KW - Asthma -- genetics KW - Arginase -- genetics KW - Hypersensitivity -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67606122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Genetic+polymorphisms+in+arginase+I+and+II+and+childhood+asthma+and+atopy.&rft.au=Li%2C+Huiling%3BRomieu%2C+Isabelle%3BSienra-Monge%2C+Juan-Jose%3BRamirez-Aguilar%2C+Matiana%3BEstela+Del+Rio-Navarro%2C+Blanca%3BKistner%2C+Emily+O%3BGjessing%2C+H%C3%A5kon+K%3BLara-Sanchez%2C+Irma+Del+Carmen%3BChiu%2C+Grace+Y%3BLondon%2C+Stephanie+J&rft.aulast=Li&rft.aufirst=Huiling&rft.date=2006-01-01&rft.volume=117&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2006-01-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2004 Dec 1;173(11):6914-20 [15557187] J Appl Genet. 2005;46(1):93-104 [15741670] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2186-91 [15684051] Am J Respir Crit Care Med. 2005 Jun 15;171(12):1358-62 [15764725] Ann Hum Genet. 2006 May;70(Pt 3):382-96 [16674560] Br J Pharmacol. 1999 Nov;128(5):1114-20 [10556950] Am J Hum Genet. 2000 Jan;66(1):251-61 [10631155] Curr Opin Pulm Med. 1999 Jan;5(1):38-46 [10813248] J Immunol. 2001 Feb 15;166(4):2173-7 [11160269] Chest. 2001 Dec;120(6):2004-12 [11742935] Nature. 2002 Jul 25;418(6896):426-30 [12110844] Am J Hum Genet. 2002 Sep;71(3):483-91 [12119603] Pediatr Pulmonol. 2003 Mar;35(3):177-83 [12567385] Thorax. 2003 Feb;58 Suppl 1:i1-94 [12653493] Nat Genet. 2003 Jun;34(2):181-6 [12754510] J Clin Invest. 2003 Jun;111(12):1815-7 [12813015] J Clin Invest. 2003 Jun;111(12):1863-74 [12813022] Am J Physiol Lung Cell Mol Physiol. 2003 Aug;285(2):L313-21 [12679322] Trends Pharmacol Sci. 2003 Sep;24(9):450-5 [12967769] Nat Genet. 2003 Nov;35(3):258-63 [14566338] Genet Epidemiol. 2004 Jan;26(1):61-9 [14691957] J Immunol. 2004 Feb 1;172(3):1815-24 [14734765] Mol Genet Metab. 2004 Apr;81 Suppl 1:S38-44 [15050972] Science. 2004 Apr 9;304(5668):300-4 [15073379] J Allergy Clin Immunol. 2004 Apr;113(4):690-6 [15100675] Genet Epidemiol. 2004 Jul;27(1):33-42 [15185401] Am J Respir Crit Care Med. 2004 Jul 15;170(2):148-53 [15070820] Int Arch Allergy Appl Immunol. 1973;45(1):57-60 [4580380] Genetics. 1988 Nov;120(3):849-52 [3224810] Allergy. 1992 Dec;47(6):638-43 [1285570] Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36 [7663792] Genomics. 1995 Sep 20;29(2):311-22 [8666377] Nature. 1996 Apr 18;380(6575):630-3 [8602264] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6770-4 [8692893] Br J Pharmacol. 1996 Nov;119(6):1109-16 [8937712] Biochem Biophys Res Commun. 1997 Apr 17;233(2):487-91 [9144563] Clin Exp Allergy. 1997 Apr;27(4):363-71 [9146928] Am J Respir Crit Care Med. 1997 Jul;156(1):217-22 [9230751] Am J Physiol. 1997 Sep;273(3 Pt 1):L656-62 [9316502] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Hum Genet. 1998 Jul;63(1):259-66 [9634505] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental genomics: an opportunity for the NIEHS. AN - 67605585; 16393638 JF - Environmental health perspectives AU - Schwartz, David A AD - NIEHS and NTP, Durham, NC, USA. david.schwartz@niehs.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 1 VL - 114 IS - 1 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - National Institutes of Health (U.S.) KW - Gene Expression KW - Environmental Exposure KW - Toxicogenetics KW - Environmental Health KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67605585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+genomics%3A+an+opportunity+for+the+NIEHS.&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=A14&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-09 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Cell. 1996 Sep 20;86(6):973-83 [8808632] Nature. 1997 Jul 24;388(6640):394-7 [9237759] Int J Biochem Cell Biol. 2004 Feb;36(2):189-204 [14643885] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9 [16009939] Science. 2002 Apr 26;296(5568):695-8 [11976443] Mol Cell Biol. 2003 Aug;23(15):5293-300 [12861015] Science. 2005 Jun 3;308(5727):1466-9 [15933200] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans. AN - 67603807; 16391193 AB - The present study estimated radiation-absorbed doses of the dopamine D(1) receptor radioligand [(11)C]((+)-8-chloro-5-(7-benzofuranyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) (NNC 112) in humans, based on dynamic whole-body PET in healthy subjects. Whole-body PET was performed on 7 subjects after injection of 710 +/- 85 MBq of (11)C-NNC 112. Fourteen frames were acquired for a total of 120 min in 7 segments of the body. Regions of interest were drawn on compressed planar images of source organs that could be identified. Radiation dose estimates were calculated from organ residence times using the OLINDA 1.0 program. The organs with the highest radiation-absorbed doses were the gallbladder, liver, lungs, kidneys, and urinary bladder wall. Biexponential fitting of mean bladder activity demonstrated that 15% of activity was excreted via the urine. With a 2.4-h voiding interval, the effective dose was 5.7 microSv/MBq (21.1 mrem/mCi). (11)C-NNC 112 displays a favorable radiation dose profile in humans and would allow multiple PET examinations per year to be performed on the same subject. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Cropley, Vanessa L AU - Fujita, Masahiro AU - Musachio, John L AU - Hong, Jinsoo AU - Ghose, Subroto AU - Sangare, Janet AU - Nathan, Pradeep J AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-0135, USA. cropleyv@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 100 EP - 104 VL - 47 IS - 1 SN - 0161-5505, 0161-5505 KW - Benzazepines KW - 0 KW - Benzofurans KW - Radiopharmaceuticals KW - Receptors, Dopamine D1 KW - NNC 112 KW - 125341-24-4 KW - Index Medicus KW - Radiopharmaceuticals -- pharmacokinetics KW - Radiation Dosage KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Organ Specificity KW - Tissue Distribution KW - Radioligand Assay KW - Male KW - Female KW - Whole Body Imaging -- methods KW - Positron-Emission Tomography -- methods KW - Whole-Body Counting -- methods KW - Benzofurans -- pharmacokinetics KW - Receptors, Dopamine D1 -- metabolism KW - Benzazepines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67603807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Whole-body+biodistribution+and+estimation+of+radiation-absorbed+doses+of+the+dopamine+D1+receptor+radioligand+11C-NNC+112+in+humans.&rft.au=Cropley%2C+Vanessa+L%3BFujita%2C+Masahiro%3BMusachio%2C+John+L%3BHong%2C+Jinsoo%3BGhose%2C+Subroto%3BSangare%2C+Janet%3BNathan%2C+Pradeep+J%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Cropley&rft.aufirst=Vanessa&rft.date=2006-01-01&rft.volume=47&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. AN - 67600627; 16289397 AB - Gamma-aminobutyric acid (GABA)ergic adaptations contribute to the neurobiology of ethanol dependence and withdrawal. Clinical data suggest that tobacco smoking attenuates alcohol withdrawal symptoms. This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking. Proton magnetic resonance spectroscopy (MRS) was used to measure occipital cortical N-acetylaspartate (NAA), glutamate plus glutamine, and GABA in 12 ethanol-dependent men at approximately 1 week and 1 month of medication-free sobriety on an inpatient unit. Eight healthy men were studied once. The tissue composition of the MRS volume was determined. Adjusting for less white matter in patients, GABA differed insignificantly between ethanol-dependent patients (smokers plus nonsmokers) and healthy subjects. In early sobriety, nonsmoking patients had more GABA than did smoking patients, but by 1 month, GABA decreased in nonsmokers without changing in smokers. Smoking was associated with increased glutamate plus glutamine in patients and healthy subjects, adjusting for NAA levels. These data do not show that deficits in cortical GABA contribute directly to acute ethanol withdrawal. If smoking prevents withdrawal-related changes in cortical GABA systems, it may contribute to comorbidity of alcoholism and tobacco smoking. JF - Biological psychiatry AU - Mason, Graeme F AU - Petrakis, Ismene L AU - de Graaf, Robin A AU - Gueorguieva, Ralitza AU - Guidone, Elizabeth AU - Coric, Vladimir AU - Epperson, C Neill AU - Rothman, Douglas L AU - Krystal, John H AD - NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA. graeme.mason@yale.edu Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 85 EP - 93 VL - 59 IS - 1 SN - 0006-3223, 0006-3223 KW - Aspartic Acid KW - 30KYC7MIAI KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - N-acetylaspartate KW - 997-55-7 KW - Creatine KW - MU72812GK0 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Creatine -- metabolism KW - Aspartic Acid -- metabolism KW - Magnetic Resonance Spectroscopy -- methods KW - Aspartic Acid -- analogs & derivatives KW - Humans KW - Adult KW - Choline -- metabolism KW - Middle Aged KW - Male KW - Alcoholism -- therapy KW - Smoking -- metabolism KW - Occipital Lobe -- metabolism KW - Alcoholism -- metabolism KW - gamma-Aminobutyric Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67600627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Cortical+gamma-aminobutyric+acid+levels+and+the+recovery+from+ethanol+dependence%3A+preliminary+evidence+of+modification+by+cigarette+smoking.&rft.au=Mason%2C+Graeme+F%3BPetrakis%2C+Ismene+L%3Bde+Graaf%2C+Robin+A%3BGueorguieva%2C+Ralitza%3BGuidone%2C+Elizabeth%3BCoric%2C+Vladimir%3BEpperson%2C+C+Neill%3BRothman%2C+Douglas+L%3BKrystal%2C+John+H&rft.aulast=Mason&rft.aufirst=Graeme&rft.date=2006-01-01&rft.volume=59&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-21 N1 - Date created - 2006-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutated mouse and human myocilins have similar properties and do not block general secretory pathway. AN - 67599859; 16384964 AB - The present study compared properties of wild-type and mutated mouse and human myocilin (Myoc) proteins as a prerequisite for development of a mouse model of glaucoma. cDNA encoding full-length mouse Myoc was cloned into the p3XFLAG-CMV-14 vector. Tyr423His and Ile463Ser mutations were introduced into the mouse Myoc protein by in vitro mutagenesis. Intracellular localization and secretion of wild-type and mutated mouse Myoc proteins were studied in immunostaining and Western blotting experiments, respectively, after transfection into COS-7 cells. Similar to human MYOC, wild-type and mutated mouse Myoc demonstrated vesicular staining in transfected cells. However, while wild-type human and mouse Myoc were preferentially located in both the endoplasmic reticulum and Golgi, mutated human and mouse Myoc were located mainly in the endoplasmic reticulum and were excluded from Golgi. Similar to mutations in human MYOC, mutations in mouse Myoc dramatically reduced its secretion from transfected cells. Secretion of mutated Myoc was partially restored by culturing cells at 30 degrees C instead of 37 degrees C. The presence of mutated human MYOC prevented secretion of wild-type mouse Myoc but did not dramatically affect secretion of alkaline phosphatase, thrombospondin, Timp3 or olfactomedin-1. Properties of the mouse Myoc protein are similar to those of the human MYOC. The presence of mutated mouse or human Myoc does not block a general secretory pathway. Expression of mutated Myoc in the eye in mice may mimic human glaucoma and lead to development of a genetic mouse model of glaucoma. JF - Investigative ophthalmology & visual science AU - Malyukova, Irina AU - Lee, Hee-Sheung AU - Fariss, Robert N AU - Tomarev, Stanislav I AD - Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 206 EP - 212 VL - 47 IS - 1 SN - 0146-0404, 0146-0404 KW - Cytoskeletal Proteins KW - 0 KW - Extracellular Matrix Proteins KW - Eye Proteins KW - Glycoproteins KW - olfactomedin KW - trabecular meshwork-induced glucocorticoid response protein KW - Index Medicus KW - Endoplasmic Reticulum -- metabolism KW - Animals KW - Humans KW - Amino Acid Sequence KW - Mice KW - Plasmids KW - Mutagenesis, Site-Directed KW - Blotting, Western KW - Mutation -- physiology KW - COS Cells -- metabolism KW - Cercopithecus aethiops KW - Extracellular Matrix Proteins -- genetics KW - Molecular Sequence Data KW - Golgi Apparatus -- metabolism KW - Transfection KW - Cytoskeletal Proteins -- physiology KW - Genetic Vectors KW - Eye Proteins -- physiology KW - Glycoproteins -- genetics KW - Glycoproteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67599859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Mutated+mouse+and+human+myocilins+have+similar+properties+and+do+not+block+general+secretory+pathway.&rft.au=Malyukova%2C+Irina%3BLee%2C+Hee-Sheung%3BFariss%2C+Robert+N%3BTomarev%2C+Stanislav+I&rft.aulast=Malyukova&rft.aufirst=Irina&rft.date=2006-01-01&rft.volume=47&rft.issue=1&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2005-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells. AN - 67599828; 16275896 AB - Mast cells (MCs) are common components of inflammatory infiltrates and a source of proangiogenic factors. Inflammation is often accompanied by vascular changes. However, little is known about modulation of MC-derived proangiogenic factors during inflammation. In this study, we evaluated the effects of the proinflammatory mediator prostaglandin E2 (PGE2) on MC expression and release of proangiogenic factors. We report that PGE2 dose-dependently induces primary MCs to release the proangiogenic chemokine monocyte chemoattractant protein-1 (MCP-1). This release of MCP-1 is complete by 2 h after PGE2 exposure, reaches levels of MCP-1 at least 15-fold higher than background, and is not accompanied by degranulation or increased MCP-1 gene expression. By immunoelectron microscopy, MCP-1 is detected within MCs at a cytoplasmic location distinct from the secretory granules. Dexamethasone and cyclosporine A inhibit PGE2-induced MCP-1 secretion by approximately 60%. Agonists of PGE2 receptor subtypes revealed that the EP1 and EP3 receptors can independently mediate MCP-1 release from MCs. These observations identify PGE2-induced MCP-1 release from MCs as a pathway underlying inflammation-associated angiogenesis and extend current understanding of the activities of PGE2. JF - Journal of leukocyte biology AU - Nakayama, Takayuki AU - Mutsuga, Noriko AU - Yao, Lei AU - Tosato, Giovanna AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Nakayamt@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 95 EP - 104 VL - 79 IS - 1 SN - 0741-5400, 0741-5400 KW - Angiogenesis Inducing Agents KW - 0 KW - Anti-Inflammatory Agents KW - Ccl2 protein, mouse KW - Chemokine CCL2 KW - Immunosuppressive Agents KW - Oxytocics KW - Dexamethasone KW - 7S5I7G3JQL KW - Cyclosporine KW - 83HN0GTJ6D KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Secretory Vesicles -- ultrastructure KW - Dose-Response Relationship, Drug KW - Secretory Vesicles -- secretion KW - Dexamethasone -- pharmacology KW - Mice KW - Neovascularization, Pathologic -- pathology KW - Immunosuppressive Agents -- pharmacology KW - Neovascularization, Pathologic -- immunology KW - Cells, Cultured KW - Cyclosporine -- pharmacology KW - Inflammation -- immunology KW - Inflammation -- metabolism KW - Secretory Vesicles -- immunology KW - Drug Antagonism KW - Anti-Inflammatory Agents -- pharmacology KW - Inflammation -- pathology KW - Mast Cells -- secretion KW - Dinoprostone -- immunology KW - Angiogenesis Inducing Agents -- metabolism KW - Angiogenesis Inducing Agents -- immunology KW - Mast Cells -- immunology KW - Dinoprostone -- pharmacology KW - Oxytocics -- immunology KW - Chemokine CCL2 -- secretion KW - Oxytocics -- pharmacology KW - Chemokine CCL2 -- immunology KW - Mast Cells -- ultrastructure KW - Cell Degranulation -- immunology KW - Cell Degranulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67599828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Prostaglandin+E2+promotes+degranulation-independent+release+of+MCP-1+from+mast+cells.&rft.au=Nakayama%2C+Takayuki%3BMutsuga%2C+Noriko%3BYao%2C+Lei%3BTosato%2C+Giovanna&rft.aulast=Nakayama&rft.aufirst=Takayuki&rft.date=2006-01-01&rft.volume=79&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. AN - 67598743; 16374844 AB - The authors reviewed 77 published reports available before August 1, 2005 that examined the ability of hematopoietic cells to generate hepatocytes in the liver. A list of these publications and a synopsis of each are available on-line. We interpret the evidence provided by this data set to suggest that one or more types of hematopoietic cells may rarely acquire the hepatocyte phenotype in the liver (frequency < or =10(-4)), although the nature of the hematopoietic cells involved and the mechanisms responsible for acquisition of a hepatocyte phenotype are still controversial. Hematopoietic stem cells do not appear to be direct precursors of hepatocytes, which, instead, can be generated from cells of the macrophage-monocyte lineage. Fusion between hepatocytes and transplanted hematopoietic cells has been substantiated as a mechanism by which hepatocytes that carry a bone marrow tag are generated, but direct transdifferentiation of hematopoietic cells has not been demonstrated. In conclusion, hematopoietic cells contribute little to hepatocyte formation under either physiological or pathological conditions, although they may provide cytokines and growth factors that promote hepatocyte functions by paracrine mechanisms. Cells of the endodermal hepatocyte lineage are far more potent generators of hepatocytes than are hematopoietic cells. JF - Hepatology (Baltimore, Md.) AU - Thorgeirsson, Snorri S AU - Grisham, Joe W AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD 20892-4262, USA. snorri_thorgeirsson@nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 2 EP - 8 VL - 43 IS - 1 SN - 0270-9139, 0270-9139 KW - Index Medicus KW - Animals KW - Cell Lineage KW - Humans KW - Cell Differentiation KW - Bone Marrow Cells -- cytology KW - Hematopoietic Stem Cells -- cytology KW - Hepatocytes -- physiology KW - Hepatocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67598743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Hematopoietic+cells+as+hepatocyte+stem+cells%3A+a+critical+review+of+the+evidence.&rft.au=Thorgeirsson%2C+Snorri+S%3BGrisham%2C+Joe+W&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2006-01-01&rft.volume=43&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic enhancement of cytokine-induced human monocyte matrix metalloproteinase-1 by C-reactive protein and oxidized LDL through differential regulation of monocyte chemotactic protein-1 and prostaglandin E2. AN - 67597264; 16244112 AB - C-reactive protein (CRP) and oxidized LDL (ox-LDL) are associated with inflammatory lesions, such as coronary artery disease, in which monocytes and matrix metalloproteinases (MMPs) may play a major role in the rupture of atherosclerotic plaques. Monocytes are recruited to inflammation sites by monocyte chemoattractant protein-1 (MCP-1), which may also participate in the activation of monocytes. The objective of this study was to compare the individual and combined effect of CRP and ox-LDL on human monocyte MMP-1 and the role of MCP-1 in this effect. Although CRP or ox-LDL failed to induce MMP-1 in control monocytes, these molecules enhanced MMP-1 production induced by tumor necrosis factor alpha (TNF-alpha) and granulocyte macrophage-colony stimulating factor (GM-CSF) with a synergistic increase in MMP-1 occurring in the presence of both mediators. Enhancement of MMP-1 by CRP and ox-LDL was attributable to a differential increase in MCP-1 and prostaglandin E2(PGE2). CRP, at physiological concentrations, induced high levels of MCP-1 and relatively low levels of PGE2, whereas ox-LDL caused a significant enhancement of PGE2 with little affect on MCP-1. Accordingly, CRP- and ox-LDL-induced MMP-1 production by monocytes was inhibited by anti-MCP-1 antibodies and indomethacin, respectively. Moreover, addition of exogenous MCP-1 or PGE2 enhanced MMP-1 production by TNF-alpha- and GM-CSF-stimulated monocytes. These results show that the combination of CRP and ox-LDL can cause a synergistic enhancement of the role of monocytes in inflammation, first, by increasing MCP-1, which attracts more monocytes and directly enhances MMP-1 production by activated monocytes, and second, by elevating PGE2 production, which also leads to higher levels of MMP-1. JF - Journal of leukocyte biology AU - Zhang, Yahong AU - Wahl, Larry M AD - Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4352, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 105 EP - 113 VL - 79 IS - 1 SN - 0741-5400, 0741-5400 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antibodies, Monoclonal KW - CCL2 protein, human KW - Chemokine CCL2 KW - Lipoproteins, LDL KW - Oxytocics KW - Tumor Necrosis Factor-alpha KW - oxidized low density lipoprotein KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - C-Reactive Protein KW - 9007-41-4 KW - Matrix Metalloproteinase 1 KW - EC 3.4.24.7 KW - Dinoprostone KW - K7Q1JQR04M KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Granulocyte-Macrophage Colony-Stimulating Factor -- immunology KW - Cell Movement -- immunology KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Tumor Necrosis Factor-alpha -- immunology KW - Coronary Artery Disease -- pathology KW - Gene Expression Regulation, Enzymologic -- immunology KW - Antibodies, Monoclonal -- pharmacology KW - Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology KW - Macrophage Activation -- drug effects KW - Indomethacin -- pharmacology KW - Antibodies, Monoclonal -- immunology KW - Coronary Artery Disease -- enzymology KW - Coronary Artery Disease -- immunology KW - Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Cell Movement -- drug effects KW - Drug Synergism KW - Macrophage Activation -- immunology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Dinoprostone -- immunology KW - Matrix Metalloproteinase 1 -- immunology KW - Dinoprostone -- pharmacology KW - C-Reactive Protein -- immunology KW - Monocytes -- enzymology KW - Oxytocics -- pharmacology KW - Chemokine CCL2 -- immunology KW - C-Reactive Protein -- pharmacology KW - Matrix Metalloproteinase 1 -- secretion KW - Monocytes -- immunology KW - Oxytocics -- immunology KW - Monocytes -- pathology KW - Chemokine CCL2 -- pharmacology KW - Lipoproteins, LDL -- pharmacology KW - Lipoproteins, LDL -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67597264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Synergistic+enhancement+of+cytokine-induced+human+monocyte+matrix+metalloproteinase-1+by+C-reactive+protein+and+oxidized+LDL+through+differential+regulation+of+monocyte+chemotactic+protein-1+and+prostaglandin+E2.&rft.au=Zhang%2C+Yahong%3BWahl%2C+Larry+M&rft.aulast=Zhang&rft.aufirst=Yahong&rft.date=2006-01-01&rft.volume=79&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in attitude, changes in latitude: nuclear receptors remodeling chromatin to regulate transcription. AN - 67596615; 16002433 AB - Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate important physiological processes. To activate or repress genes assembled naturally as chromatin, NRs recruit two distinct enzymatic activities, namely histone-modifying enzymes and ATP-dependent chromatin remodeling complexes, to alter local chromatin structure at target gene promoters. In this review, we examine the functional relationship between ATP-dependent chromatin remodeling complexes and NRs in the context of transcriptional regulation. Using the steroid-responsive mouse mammary tumor virus promoter as a model system, we discuss in detail the molecular mechanisms underlying the recruitment of these complexes and subsequent chromatin structure changes catalyzed by this group of enzymes. In addition, we extend the discussion to other NR-regulated promoters including the pS2 promoter. Finally, we summarize specific principles governing this critical relationship, identify unanswered questions and discuss the potential application of these principles in rational drug design. JF - Molecular endocrinology (Baltimore, Md.) AU - Chen, Jianguang AU - Kinyamu, H Karimi AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 1 EP - 13 VL - 20 IS - 1 SN - 0888-8809, 0888-8809 KW - Chromatin KW - 0 KW - Membrane Proteins KW - Mtvr2 protein, mouse KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Virus KW - Transcription Factors KW - Index Medicus KW - Animals KW - Transcription Factors -- metabolism KW - Humans KW - Receptors, Virus -- genetics KW - Mice KW - Membrane Proteins -- genetics KW - Protein Structure, Tertiary KW - Transcription Factors -- genetics KW - Mammary Tumor Virus, Mouse -- genetics KW - Promoter Regions, Genetic KW - Chromatin -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Chromatin Assembly and Disassembly KW - Transcription, Genetic KW - Chromatin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67596615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Changes+in+attitude%2C+changes+in+latitude%3A+nuclear+receptors+remodeling+chromatin+to+regulate+transcription.&rft.au=Chen%2C+Jianguang%3BKinyamu%2C+H+Karimi%3BArcher%2C+Trevor+K&rft.aulast=Chen&rft.aufirst=Jianguang&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-07 N1 - Date created - 2005-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NPY in alcoholism and psychiatric disorders. AN - 67596341; 16383007 JF - EXS AU - Thorsell, Annika AU - Karlsson, Rose-Marie AU - Heilig, Markus AD - NIH/NIAAA, LCS, Building 10-CRC/Room 1-5330, 10 Center Drive, Bethesda, Maryland 20892, USA. annika.thorsell@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 183 EP - 192 IS - 95 SN - 1023-294X, 1023-294X KW - Neuropeptide Y KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neuropeptide Y -- metabolism KW - Mental Disorders -- drug therapy KW - Alcoholism -- metabolism KW - Neuropeptide Y -- physiology KW - Mental Disorders -- metabolism KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67596341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EXS&rft.atitle=NPY+in+alcoholism+and+psychiatric+disorders.&rft.au=Thorsell%2C+Annika%3BKarlsson%2C+Rose-Marie%3BHeilig%2C+Markus&rft.aulast=Thorsell&rft.aufirst=Annika&rft.date=2006-01-01&rft.volume=&rft.issue=95&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=EXS&rft.issn=1023294X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2005-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of plasma protein binding on the renal transport of organic anions. AN - 67592188; 16195420 AB - Drugs and xenobiotics bind to plasma proteins with varying degrees of affinity, and the amount of binding has a direct effect on free drug concentration and subsequent pharmacokinetics. Multiple active and facilitative transport systems regulate the excretion of anionic compounds from the blood in excretory and barrier tissues. Assumptions are made about in vivo substrate affinity and route of elimination based on data from plasma protein-free in vitro assays, particularly following expression of cloned transporters. Ochratoxin A (OTA), a fungal mycotoxin, is a high-affinity substrate for several renal secretory organic anion transporters (OATs), and literature suggests that this elimination pathway is the route of entry leading to proximal tubule-targeted toxicity. However, OTA is known to bind to several plasma proteins with a high affinity, particularly serum albumin, which may impact elimination. In this study, we have systematically examined the handling of OTA and other organic anions, estrone sulfate (ES) and methotrexate (MTX), by OATs in the presence of serum albumin. Increasing concentrations of albumin markedly reduced uptake of OTA by both Xenopus laevis oocytes expressing OATs 1, 3, and 4 and organic anion-transporting polypeptide 1. For all transporters tested, virtually all mediated OTA uptake was eliminated by an albumin concentration equivalent to 10% of that present in the blood plasma. Thus, OTA uptake is dependent on the free substrate concentration and severely limited by binding to human serum albumin. MTX and ES uptake were likewise dependent on free concentration. JF - The Journal of pharmacology and experimental therapeutics AU - Bow, Daniel A J AU - Perry, Jennifer L AU - Simon, John D AU - Pritchard, John B AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Mail Drop F1-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 349 EP - 355 VL - 316 IS - 1 SN - 0022-3565, 0022-3565 KW - Blood Proteins KW - 0 KW - Folic Acid Antagonists KW - Ochratoxins KW - Organic Anion Transporters KW - RNA, Complementary KW - Serum Albumin KW - ochratoxin A KW - 1779SX6LUY KW - Estrone KW - 2DI9HA706A KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Serum Albumin -- metabolism KW - Animals KW - Biological Transport, Active -- physiology KW - Estrone -- metabolism KW - Folic Acid Antagonists -- metabolism KW - Protein Binding KW - Xenopus laevis KW - Ochratoxins -- metabolism KW - Oocytes -- metabolism KW - In Vitro Techniques KW - Dogs KW - RNA, Complementary -- biosynthesis KW - Methotrexate -- metabolism KW - Cell Line KW - Kidney -- metabolism KW - Organic Anion Transporters -- metabolism KW - Blood Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=The+impact+of+plasma+protein+binding+on+the+renal+transport+of+organic+anions.&rft.au=Bow%2C+Daniel+A+J%3BPerry%2C+Jennifer+L%3BSimon%2C+John+D%3BPritchard%2C+John+B&rft.aulast=Bow&rft.aufirst=Daniel+A&rft.date=2006-01-01&rft.volume=316&rft.issue=1&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-31 N1 - Date created - 2005-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances in understanding angiogenesis through molecular studies. AN - 67591602; 16377412 AB - Tumors, in most cases, need angiogenesis for their sustained growth. A great deal of evidence has suggested that the process of angiogenesis is regulated by the balance between proangiogenic and antiangiogenic factors. Thus, the inhibition of tumor angiogenesis has been considered to be one of the key targets in anticancer therapy, and more than 60 antiangiogenic compounds are currently under clinical evaluation in cancer patients. However, the molecular mechanisms responsible for the activity of many of these antiangiogenic compounds are still not well understood. The recent development of microarray technology has allowed us to investigate the mechanism of action of these inhibitors more rapidly and extensively. With the use of microarray technology, novel molecules and pathways are shown to play a role in angiogenesis. This article also reviews new experimental approaches combined with microarray analysis to identify the molecular pathways involved in tumor-host interactions. Elucidation of the pathways that mediate both angiogenic and antiangiogenic responses will help us to develop better anticancer therapies. JF - International journal of radiation oncology, biology, physics AU - Kwon, Mijung AU - Libutti, Steven K AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA. Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 26 EP - 32 VL - 64 IS - 1 SN - 0360-3016, 0360-3016 KW - Angiogenesis Inhibitors KW - 0 KW - Angiogenic Proteins KW - Cell Cycle Proteins KW - Cyclohexanes KW - Endostatins KW - Fatty Acids, Unsaturated KW - Immediate-Early Proteins KW - Sesquiterpenes KW - fumagillin KW - 7OW73204U1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Protein Phosphatase 1 KW - DUSP1 protein, human KW - EC 3.1.3.48 KW - Dual Specificity Phosphatase 1 KW - Protein Tyrosine Phosphatases KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Endothelium, Vascular -- metabolism KW - Protein Tyrosine Phosphatases -- genetics KW - Humans KW - Neovascularization, Physiologic -- genetics KW - Endostatins -- pharmacology KW - Mitogen-Activated Protein Kinases -- physiology KW - Immediate-Early Proteins -- genetics KW - Endothelium, Vascular -- drug effects KW - Cell Cycle Proteins -- genetics KW - Phosphoprotein Phosphatases -- genetics KW - Fatty Acids, Unsaturated -- pharmacology KW - Drug Synergism KW - Neovascularization, Physiologic -- physiology KW - Angiogenesis Inhibitors -- pharmacology KW - Neovascularization, Pathologic -- etiology KW - Neoplasms -- blood supply KW - Neovascularization, Pathologic -- genetics KW - Angiogenesis Inhibitors -- metabolism KW - Microarray Analysis -- methods KW - Neovascularization, Pathologic -- prevention & control KW - Angiogenic Proteins -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67591602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Advances+in+understanding+angiogenesis+through+molecular+studies.&rft.au=Kwon%2C+Mijung%3BLibutti%2C+Steven+K&rft.aulast=Kwon&rft.aufirst=Mijung&rft.date=2006-01-01&rft.volume=64&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase III randomized study on the sequencing of radiotherapy and chemotherapy in the conservative management of early-stage breast cancer. AN - 67589795; 16226397 AB - To compare two different timings of radiation treatment in patients with breast cancer who underwent conservative surgery and were candidates to receive adjuvant cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy. A total of 206 patients who had quadrantectomy and axillary dissection for breast cancer and were planned to receive adjuvant CMF chemotherapy were randomized to concurrent or sequential radiotherapy. Radiotherapy was delivered only to the whole breast through tangential fields to a dose of 50 Gy in 20 fractions over 4 weeks, followed by an electron boost of 10-15 Gy in 4-6 fractions to the tumor bed. No differences in 5-year breast recurrence-free, metastasis-free, disease-free, and overall survival were observed in the two treatment groups. All patients completed the planned radiotherapy. No evidence of an increased risk of toxicity was observed between the two arms. No difference in radiotherapy and in the chemotherapy dose intensity was observed in the two groups. In patients with negative surgical margins receiving adjuvant chemotherapy, radiotherapy can be delayed to up to 7 months. Concurrent administration of CMF chemotherapy and radiotherapy is safe and might be reserved for patients at high risk of local recurrence, such as those with positive surgical margins or larger tumor diameters. JF - International journal of radiation oncology, biology, physics AU - Arcangeli, Giorgio AU - Pinnarò, Paola AU - Rambone, Rita AU - Giannarelli, Diana AU - Benassi, Marcello AD - Regina Elena National Cancer Institute, Rome, Italy. arcangeli@ifo.it Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 161 EP - 167 VL - 64 IS - 1 SN - 0360-3016, 0360-3016 KW - Tamoxifen KW - 094ZI81Y45 KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Humans KW - Mastectomy, Segmental KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Radiotherapy, Adjuvant KW - Adult KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Adolescent KW - Lymph Node Excision KW - Methotrexate -- administration & dosage KW - Chemotherapy, Adjuvant KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- surgery KW - Breast Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67589795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=A+phase+III+randomized+study+on+the+sequencing+of+radiotherapy+and+chemotherapy+in+the+conservative+management+of+early-stage+breast+cancer.&rft.au=Arcangeli%2C+Giorgio%3BPinnar%C3%B2%2C+Paola%3BRambone%2C+Rita%3BGiannarelli%2C+Diana%3BBenassi%2C+Marcello&rft.aulast=Arcangeli&rft.aufirst=Giorgio&rft.date=2006-01-01&rft.volume=64&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-23 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):632; author reply 632-3 [16690446] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genome engineering in Bacillus anthracis using Cre recombinase. AN - 67589699; 16369025 AB - Genome engineering is a powerful method for the study of bacterial virulence. With the availability of the complete genomic sequence of Bacillus anthracis, it is now possible to inactivate or delete selected genes of interest. However, many current methods for disrupting or deleting more than one gene require use of multiple antibiotic resistance determinants. In this report we used an approach that temporarily inserts an antibiotic resistance marker into a selected region of the genome and subsequently removes it, leaving the target region (a single gene or a larger genomic segment) permanently mutated. For this purpose, a spectinomycin resistance cassette flanked by bacteriophage P1 loxP sites oriented as direct repeats was inserted within a selected gene. After identification of strains having the spectinomycin cassette inserted by a double-crossover event, a thermo-sensitive plasmid expressing Cre recombinase was introduced at the permissive temperature. Cre recombinase action at the loxP sites excised the spectinomycin marker, leaving a single loxP site within the targeted gene or genomic segment. The Cre-expressing plasmid was then removed by growth at the restrictive temperature. The procedure could then be repeated to mutate additional genes. In this way, we sequentially mutated two pairs of genes: pepM and spo0A, and mcrB and mrr. Furthermore, loxP sites introduced at distant genes could be recombined by Cre recombinase to cause deletion of large intervening regions. In this way, we deleted the capBCAD region of the pXO2 plasmid and the entire 30 kb of chromosomal DNA between the mcrB and mrr genes, and in the latter case we found that the 32 intervening open reading frames were not essential to growth. JF - Infection and immunity AU - Pomerantsev, Andrei P AU - Sitaraman, Ramakrishnan AU - Galloway, Craig R AU - Kivovich, Violetta AU - Leppla, Stephen H AD - Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-4349, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 682 EP - 693 VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - Bacterial Proteins KW - 0 KW - Recombinant Proteins KW - Viral Proteins KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Index Medicus KW - Base Sequence KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- biosynthesis KW - Recombinant Proteins -- biosynthesis KW - Molecular Sequence Data KW - Recombinant Proteins -- genetics KW - Plasmids KW - Mutagenesis, Insertional KW - Gene Deletion KW - Viral Proteins -- genetics KW - Genome, Bacterial KW - Bacillus anthracis -- genetics KW - Genetic Engineering KW - Integrases -- genetics KW - Organisms, Genetically Modified UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67589699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Genome+engineering+in+Bacillus+anthracis+using+Cre+recombinase.&rft.au=Pomerantsev%2C+Andrei+P%3BSitaraman%2C+Ramakrishnan%3BGalloway%2C+Craig+R%3BKivovich%2C+Violetta%3BLeppla%2C+Stephen+H&rft.aulast=Pomerantsev&rft.aufirst=Andrei&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2005-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1989 Nov;171(11):6187-96 [2509430] Infect Immun. 1985 Aug;49(2):291-7 [3926644] J Bacteriol. 1992 Sep;174(17):5633-8 [1324906] J Bacteriol. 1994 Feb;176(3):586-95 [8300513] Gene. 1995 Jan 11;152(1):75-8 [7828932] Genetika. 1996 Apr;32(4):500-9 [8754064] Appl Environ Microbiol. 1998 Mar;64(3):982-91 [9501438] Gene. 1998 Sep 14;217(1-2):31-40 [9795118] Can J Microbiol. 1999 Jan;45(1):1-8 [10349715] J Pathol Bacteriol. 1951 Oct;63(4):673-85 [14898372] J Gen Microbiol. 1957 Oct;17(2):505-16 [13481332] J Bacteriol. 2005 Aug;187(15):5108-14 [16030203] Mol Microbiol. 2005 Aug;57(3):717-26 [16045616] J Mol Biol. 2002 May 24;319(1):107-27 [12051940] J Bacteriol. 1999 Nov;181(21):6585-90 [10542157] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] Gene. 2000 Apr 18;247(1-2):255-64 [10773465] J Bacteriol. 2000 May;182(10):2928-36 [10781564] Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8063-8 [10869437] Mol Microbiol. 2001 Jan;39(2):236-47 [11136446] J Bacteriol. 2002 Jan;184(1):76-81 [11741846] J Bacteriol. 2002 Jan;184(2):370-80 [11751813] Appl Environ Microbiol. 2002 Jan;68(1):227-34 [11772631] Appl Environ Microbiol. 2002 May;68(5):2359-67 [11976109] J Clin Invest. 2002 Jul;110(2):141-4 [12122102] J Infect Dis. 2002 Jul 15;186(2):227-33 [12134259] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4678-83 [12682299] Nature. 2003 May 1;423(6935):81-6 [12721629] Infect Immun. 2003 Nov;71(11):6591-606 [14573681] Mol Microbiol. 2004 Jan;51(2):511-22 [14756790] J Bacteriol. 1971 Jun;106(3):1016-25 [4104235] J Mol Biol. 1981 Aug 25;150(4):603-8 [6460113] Infect Immun. 1983 Jan;39(1):371-6 [6401695] Cell. 1983 Sep;34(2):693-7 [6413077] J Bacteriol. 1985 May;162(2):543-50 [3988702] J Bacteriol. 1992 May;174(9):2771-8 [1569009] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes. AN - 67583036; 16293411 AB - Cumulative peripheral neuropathy (PNP) still remains a limitation to optimal treatment with paclitaxel (PAC), especially in more dose-dense schedules. This primary sensory PNP may affect the majority of patients after administration of certain cumulative dosages of PAC, while the exact mechanisms of PAC-induced PNP are not known. While a number of preclinical models revealed its vehicle Cremophor EL (CrEL) to be mainly responsible for ganglionopathy, axonopathy and demyelination, clinical data also supports a strong and independent effect of PAC itself, which is most likely based on disturbances in the microtubules in perikaryons, axons and glia cells. Indeed, clinical trials of CrEL-free formulations of PAC still report grade III neurotoxicity as dose-limiting. As treatment options of PAC-induced PNP are rare the use of specific scoring systems for screening purposes is strongly encouraged. In this report we review and discuss the pathogenesis, incidence, risk factors, diagnosis, pharmacodynamics and treatment options for PAC-induced PNP. JF - European journal of cancer (Oxford, England : 1990) AU - Mielke, Stephan AU - Sparreboom, Alex AU - Mross, Klaus AD - Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany. mielkes@nhlbi.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 24 EP - 30 VL - 42 IS - 1 SN - 0959-8049, 0959-8049 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Pharmaceutical Vehicles KW - Polyethylene Glycols KW - 30IQX730WE KW - Paclitaxel KW - P88XT4IS4D KW - glycofurol KW - YZC5LZ8BUB KW - Index Medicus KW - Risk Factors KW - Humans KW - Prognosis KW - Pharmaceutical Vehicles -- adverse effects KW - Polyethylene Glycols -- adverse effects KW - Antineoplastic Agents, Phytogenic -- pharmacokinetics KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Paclitaxel -- pharmacokinetics KW - Peripheral Nervous System Diseases -- prevention & control KW - Peripheral Nervous System Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67583036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Peripheral+neuropathy%3A+a+persisting+challenge+in+paclitaxel-based+regimes.&rft.au=Mielke%2C+Stephan%3BSparreboom%2C+Alex%3BMross%2C+Klaus&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2006-01-01&rft.volume=42&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=09598049&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fires in the operating room and intensive care unit: awareness is the key to prevention. AN - 67580131; 16368825 AB - Recent recommendations from the Centers for Disease Control (CDC) to use alcohol-based substances for hand hygiene and skin antisepsis could introduce new fire hazards in the operating room (OR). This potential for an increase in the number of fires in the hospital setting with wide spread use of alcohol-based agents warrants heightened awareness of the risks and implementation of safety measures when using these agents. Here, we report a patient who, during a tracheostomy, sustained severe burns resulting from a fire in the OR. In this case, the use of an alcohol-based antiseptic was the major contributing factor to the surgical fire. JF - Anesthesia and analgesia AU - Prasad, Rajnish AU - Quezado, Zenaide AU - St Andre, Arthur AU - O'Grady, Naomi P AD - Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 172 EP - 174 VL - 102 IS - 1 KW - Anti-Infective Agents, Local KW - 0 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Ethanol -- adverse effects KW - Anti-Infective Agents, Local -- adverse effects KW - Humans KW - Aged KW - Female KW - Operating Rooms KW - Intensive Care Units KW - Awareness KW - Fires -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67580131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Fires+in+the+operating+room+and+intensive+care+unit%3A+awareness+is+the+key+to+prevention.&rft.au=Prasad%2C+Rajnish%3BQuezado%2C+Zenaide%3BSt+Andre%2C+Arthur%3BO%27Grady%2C+Naomi+P&rft.aulast=Prasad&rft.aufirst=Rajnish&rft.date=2006-01-01&rft.volume=102&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant treatment of malignant melanoma: where are we? AN - 67579254; 15990330 AB - To date, no standard adjuvant therapy have increased overall survival in patients with malignant melanoma (MM). The effect of interferon alpha as a single agent or in combination has been widely explored in clinical trials. Critical reading of the major international randomised trials showed that response to interferon (IFN) in terms of improvement of overall survival (OS) may not be strictly correlated with the used dosage and that duration of therapy may impact disease-free survival (DFS) but not OS. Patients' heterogeneity could be an explanation for the discordant data of the international literature. Indeed, majority of these studies started in late 1980s or early 1990s, when accurate staging procedure were not available yet. The adequate surgical treatment should be considered as an independent variable in the analysis of MM adjuvant protocols. Considering the treatment cost, which is the main goal: DFS, OS or quality of life? Answering these questions is difficult, but some considerations must be taken to put order in this field. Putting together data from all different studies, IFN therapy seems to protect MM patients from recurrences during the entire treatment period and a prolonged IFN therapy seems to improve DFS. The only positive result on OS was demonstrated for high-dose IFN (HD-IFN) in a single study (presenting a relatively short follow-up median) and not confirmed in a subsequent study from the same authors. Considering that low-dose interferon (LD-IFN) is tolerated much better than HD-IFN (about 10% versus more than 70% of cases with grade 3-4 toxicity, respectively), a prolonged LD-IFN (more than 2 years) may represent a reasonable opportunity for MM patients, also considering its advantageous cost-effectiveness. Conversely, considering the improvement of OS as the main target of MM adjuvant therapy, the "wait and watch" attitude remains the only approach to be pursued at present. It is a physician's choice. JF - Critical reviews in oncology/hematology AU - Ascierto, Paolo A AU - Scala, Stefania AU - Ottaiano, Alessandro AU - Simeone, Ester AU - de Michele, Ileana AU - Palmieri, Giuseppe AU - Castello, Giuseppe AD - Unit of Clinical Immunology, Melanoma Cooperative Group, National Cancer Institute, Via Mariano Semmola, 80131 Naples, Italy. pasciert@tin.it Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 45 EP - 52 VL - 57 IS - 1 SN - 1040-8428, 1040-8428 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Chemotherapy, Adjuvant -- methods KW - Melanoma -- surgery KW - Melanoma -- drug therapy KW - Interferons -- economics KW - Interferons -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67579254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=Adjuvant+treatment+of+malignant+melanoma%3A+where+are+we%3F&rft.au=Ascierto%2C+Paolo+A%3BScala%2C+Stefania%3BOttaiano%2C+Alessandro%3BSimeone%2C+Ester%3Bde+Michele%2C+Ileana%3BPalmieri%2C+Giuseppe%3BCastello%2C+Giuseppe&rft.aulast=Ascierto&rft.aufirst=Paolo&rft.date=2006-01-01&rft.volume=57&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=10408428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-29 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. AN - 67578840; 16210370 AB - Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic neuropeptide synthesized in the hypothalamus. A Leu34Phe missense mutation in proCART has been found in an obese family in humans. Here we show that humans bearing the Leu34Phe mutation in proCART have severely diminished levels of bioactive CART, but elevated amounts of partially processed proCART in their serum. Expression of wild-type proCART in AtT-20 cells showed that it was sorted to the regulated secretory pathway, a necessity for proper processing to bioactive CART. However, expressed Leu34Phe proCART was missorted, poorly processed, and secreted constitutively. The defective intracellular sorting of Leu34Phe proCART would account for the reduced levels of bioactive CART in affected humans. These results suggest that the obesity observed in humans bearing the Leu34Phe mutation could be due to a putative deficiency in hypothalamic bioactive CART. JF - Endocrinology AU - Yanik, Tulin AU - Dominguez, Geraldina AU - Kuhar, Michael J AU - Del Giudice, Emanuele M AU - Loh, Y Peng AD - Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4480, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 39 EP - 43 VL - 147 IS - 1 SN - 0013-7227, 0013-7227 KW - Nerve Tissue Proteins KW - 0 KW - Recombinant Proteins KW - cocaine- and amphetamine-regulated transcript protein KW - Abridged Index Medicus KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Transfection KW - Recombinant Proteins -- metabolism KW - Humans KW - Mutation, Missense KW - Male KW - Female KW - Cell Line KW - Amino Acid Substitution KW - Nerve Tissue Proteins -- deficiency KW - Obesity -- genetics KW - Nerve Tissue Proteins -- blood KW - Nerve Tissue Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67578840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+Leu34Phe+ProCART+mutation+leads+to+cocaine-+and+amphetamine-regulated+transcript+%28CART%29+deficiency%3A+a+possible+cause+for+obesity+in+humans.&rft.au=Yanik%2C+Tulin%3BDominguez%2C+Geraldina%3BKuhar%2C+Michael+J%3BDel+Giudice%2C+Emanuele+M%3BLoh%2C+Y+Peng&rft.aulast=Yanik&rft.aufirst=Tulin&rft.date=2006-01-01&rft.volume=147&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients. AN - 67578141; 16081512 AB - Xeroderma pigmentosum group C (XP-C) is a rare autosomal recessive disorder. Patients with two mutant alleles of the XPC DNA repair gene have sun sensitivity and a 1000-fold increase in skin cancers. Clinically normal parents of XP-C patients have one mutant allele and one normal allele. As a step toward evaluating cancer risk in these XPC heterozygotes we characterized cells from 16 XP families. We identified 15 causative mutations (5 frameshift, 6 nonsense and 4 splicing) in the XPC gene in cells from 16 XP probands. All had premature termination codons (PTC) and absence of normal XPC protein on western blotting. The cell lines from 26 parents were heterozygous for the same mutations. We employed a real-time quantitative reverse transcriptase-PCR assay as a rapid and sensitive method to measure XPC mRNA levels. The mean XPC mRNA levels in the cell lines from the XP-C probands were 24% (P<10(-7)) of that in 10 normal controls. This reduced XPC mRNA level in cells from XP-C patients was caused by the PTC that induces nonsense-mediated mRNA decay. The mean XPC mRNA levels in cell lines from the heterozygous XP-C carriers were intermediate (59%, P=10(-4)) between the values for the XP patients and the normal controls. This study demonstrates reduced XPC mRNA levels in XP-C patients and heterozygotes. Thus, XPC mRNA levels may be evaluated as a marker of cancer susceptibility in carriers of mutations in the XPC gene. JF - Carcinogenesis AU - Khan, Sikandar G AU - Oh, Kyu-Seon AU - Shahlavi, Tala AU - Ueda, Takahiro AU - Busch, David B AU - Inui, Hiroki AU - Emmert, Steffen AU - Imoto, Kyoko AU - Muniz-Medina, Vanessa AU - Baker, Carl C AU - DiGiovanna, John J AU - Schmidt, Deborah AU - Khadavi, Arash AU - Metin, Ahmet AU - Gozukara, Engin AU - Slor, Hanoch AU - Sarasin, Alain AU - Kraemer, Kenneth H AD - Basic Research Laboratory and Laboratory of Cellular Oncology, CCR, NCI, Bethesda, MD, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 84 EP - 94 VL - 27 IS - 1 SN - 0143-3334, 0143-3334 KW - Codon, Nonsense KW - 0 KW - DNA Primers KW - DNA-Binding Proteins KW - RNA Splice Sites KW - RNA, Messenger KW - XPC protein, human KW - 156533-34-5 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Child KW - Infant KW - Polymerase Chain Reaction KW - Blotting, Western KW - Heterozygote KW - Adult KW - Adolescent KW - Parents KW - Female KW - Male KW - DNA Repair -- genetics KW - RNA, Messenger -- metabolism KW - DNA-Binding Proteins -- genetics KW - Xeroderma Pigmentosum -- genetics KW - Mutation -- genetics KW - Xeroderma Pigmentosum -- metabolism KW - RNA, Messenger -- genetics KW - DNA-Binding Proteins -- metabolism KW - Codon, Nonsense -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67578141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Reduced+XPC+DNA+repair+gene+mRNA+levels+in+clinically+normal+parents+of+xeroderma+pigmentosum+patients.&rft.au=Khan%2C+Sikandar+G%3BOh%2C+Kyu-Seon%3BShahlavi%2C+Tala%3BUeda%2C+Takahiro%3BBusch%2C+David+B%3BInui%2C+Hiroki%3BEmmert%2C+Steffen%3BImoto%2C+Kyoko%3BMuniz-Medina%2C+Vanessa%3BBaker%2C+Carl+C%3BDiGiovanna%2C+John+J%3BSchmidt%2C+Deborah%3BKhadavi%2C+Arash%3BMetin%2C+Ahmet%3BGozukara%2C+Engin%3BSlor%2C+Hanoch%3BSarasin%2C+Alain%3BKraemer%2C+Kenneth+H&rft.aulast=Khan&rft.aufirst=Sikandar&rft.date=2006-01-01&rft.volume=27&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-12 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposures and non-Hodgkin lymphoma: where do we stand? AN - 67577656; 16361397 JF - Occupational and environmental medicine AU - Blair, A AD - National Cancer Institute, Executive Plaza South, Room 8118, Bethesda, MD 20892, USA. blaira@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 1 EP - 3 VL - 63 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Hazardous Substances -- toxicity KW - Occupational Diseases -- etiology KW - Lymphoma, Non-Hodgkin -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67577656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Occupational+exposures+and+non-Hodgkin+lymphoma%3A+where+do+we+stand%3F&rft.au=Blair%2C+A&rft.aulast=Blair&rft.aufirst=A&rft.date=2006-01-01&rft.volume=63&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Environ Med. 2002 Sep;59(9):575-93; discussion 594 [12205230] N Engl J Med. 2003 May 1;348(18):1777-85 [12724484] Clin Lymphoma. 2003 Dec;4(3):161-8 [14715098] Int J Epidemiol. 2004 Oct;33(5):945-6 [15319401] Cancer Res. 1992 Oct 1;52(19 Suppl):5566s-5569s [1394175] Occup Environ Med. 2006 Jan;63(1):17-26 [16361401] Comment On: Occup Environ Med. 2006 Jan;63(1):17-26 [16361401] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - House cleaning, a part of good housekeeping. AN - 67575975; 16359314 AB - Cellular metabolism constantly generates by-products that are wasteful or even harmful. Such compounds are excreted from the cell or are removed through hydrolysis to normal cellular metabolites by various 'house-cleaning' enzymes. Some of the most important contaminants are non-canonical nucleoside triphosphates (NTPs) whose incorporation into the nascent DNA leads to increased mutagenesis and DNA damage. Enzymes intercepting abnormal NTPs from incorporation by DNA polymerases work in parallel with DNA repair enzymes that remove lesions produced by modified nucleotides. House-cleaning NTP pyrophosphatases targeting non-canonical NTPs belong to at least four structural superfamilies: MutT-related (Nudix) hydrolases, dUTPase, ITPase (Maf/HAM1) and all-alpha NTP pyrophosphatases (MazG). These enzymes have high affinity (Km's in the micromolar range) for their natural substrates (8-oxo-dGTP, dUTP, dITP, 2-oxo-dATP), which allows them to select these substrates from a mixture containing a approximately 1000-fold excess of canonical NTPs. To date, many house-cleaning NTPases have been identified only on the basis of their side activity towards canonical NTPs and NDP derivatives. Integration of growing structural and biochemical data on these superfamilies suggests that their new family members cleanse the nucleotide pool of the products of oxidative damage and inappropriate methylation. House-cleaning enzymes, such as 6-phosphogluconolactonase, are also part of normal intermediary metabolism. Genomic data suggest that house-cleaning systems are more abundant than previously thought and include numerous analogous enzymes with overlapping functions. We discuss the structural diversity of these enzymes, their phylogenetic distribution, substrate specificity and the problem of identifying their true substrates. JF - Molecular microbiology AU - Galperin, Michael Y AU - Moroz, Olga V AU - Wilson, Keith S AU - Murzin, Alexey G AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. galperin@ncbi.nlm.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 5 EP - 19 VL - 59 IS - 1 SN - 0950-382X, 0950-382X KW - Nucleosides KW - 0 KW - Phosphates KW - Pyrophosphatases KW - EC 3.6.1.- KW - Nucleoside-Triphosphatase KW - EC 3.6.1.15 KW - Index Medicus KW - Pyrophosphatases -- chemistry KW - Molecular Structure KW - DNA Repair KW - Models, Molecular KW - Humans KW - Nucleoside-Triphosphatase -- chemistry KW - Nucleoside-Triphosphatase -- metabolism KW - Substrate Specificity KW - Pyrophosphatases -- metabolism KW - Protein Conformation KW - Binding Sites KW - Phosphates -- metabolism KW - Nucleosides -- metabolism KW - DNA Damage KW - Phosphates -- chemistry KW - Nucleosides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67575975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=House+cleaning%2C+a+part+of+good+housekeeping.&rft.au=Galperin%2C+Michael+Y%3BMoroz%2C+Olga+V%3BWilson%2C+Keith+S%3BMurzin%2C+Alexey+G&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=59&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-06 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunological consequences of thalidomide treatment in Sjögren's syndrome. AN - 67573908; 16344495 AB - To study the immunological consequences of systemic thalidomide treatment in patients with Sjögren's syndrome. Cytokine (tumour necrosis factor alpha (TNFalpha), interleukin (IL) 6) and soluble receptor (sIL2R) levels were measured in patient and control plasma (n = 7), before and after thalidomide treatment. Peripheral blood mononuclear cells were examined by FACS analysis for potential changes in specific cell populations (T cells, B cells, monocytes), and for the expression of activation markers (CD25, HLA-DR), costimulatory molecules (CD40, CD40L), TNF receptors, chemokine receptors, and adhesion molecules (L-selectin (L-sel)). Owing to adverse effects of thalidomide, the treatment interval was limited. None the less, statistically significant changes in markers of cell activation were recorded in the four treated patients. Before treatment, HLA-DR, TNFRI, CXCRI, and CXCRII were raised in the patients compared with healthy controls (p<0.05) and their expression was down regulated after treatment. B cell numbers and expression of the adhesion molecule L-sel also declined with thalidomide. Significant changes in measures of cell activation were detected during thalidomide treatment within this limited study, which upon further investigation may offer insight into the underlying immunoregulatory pathways of thalidomide. JF - Annals of the rheumatic diseases AU - Moutsopoulos, N M AU - Angelov, N AU - Sankar, V AU - Leakan, R A AU - Pillemer, S AU - Wahl, S M AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 112 EP - 114 VL - 65 IS - 1 SN - 0003-4967, 0003-4967 KW - Cytokines KW - 0 KW - Immunosuppressive Agents KW - Thalidomide KW - 4Z8R6ORS6L KW - Index Medicus KW - Lymphocyte Activation -- drug effects KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Pilot Projects KW - Cytokines -- metabolism KW - Immunophenotyping KW - Female KW - Sjogren's Syndrome -- drug therapy KW - Thalidomide -- adverse effects KW - Sjogren's Syndrome -- immunology KW - Leukocytes, Mononuclear -- immunology KW - Thalidomide -- therapeutic use KW - Leukocytes, Mononuclear -- drug effects KW - Thalidomide -- pharmacology KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- pharmacology KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67573908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+rheumatic+diseases&rft.atitle=Immunological+consequences+of+thalidomide+treatment+in+Sj%C3%B6gren%27s+syndrome.&rft.au=Moutsopoulos%2C+N+M%3BAngelov%2C+N%3BSankar%2C+V%3BLeakan%2C+R+A%3BPillemer%2C+S%3BWahl%2C+S+M&rft.aulast=Moutsopoulos&rft.aufirst=N&rft.date=2006-01-01&rft.volume=65&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+rheumatic+diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-19 N1 - Date created - 2005-12-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Med. 2000 Apr 15;108(6):487-95 [10781782] Springer Semin Immunopathol. 2001;23(1-2):131-45 [11455852] Ann Rheum Dis. 2002 Jun;61(6):554-8 [12006334] Trends Pharmacol Sci. 2004 Apr;25(4):201-9 [15063084] Ann Intern Med. 1998 Nov 15;129(10):836 [9841592] Arthritis Rheum. 2004 Jun 15;51(3):505-6 [15188341] Arthritis Rheum. 1986 May;29(5):577-85 [3718551] N Engl J Med. 1997 May 22;336(21):1487-93 [9154767] Scand J Immunol. 2004 Jun;59(6):592-9 [15182255] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation. AN - 67573209; 16140584 AB - The use of nonviral gene transfer methods in primary lymphocytes has been hampered by low gene transfer efficiency and high transfection-related toxicity. In this report, high gene transfection efficiency with low transfection-related toxicity was achieved by electroporation using in vitro-transcribed mRNA. Using these methods, >90% transgene expression with >80% viable cells was observed in stimulated primary human and murine T lymphocytes transfected with GFP or mCD62L. Electroporation of unstimulated human PBMCs or murine splenocytes with GFP RNA yielded 95 and 56% GFP+ cells, respectively. Electroporation of mRNA for NY-ESO-1, MART-1, and p53 antigen-specific TCRs into human T lymphocytes redirected these lymphocytes to recognize melanoma cell lines in an MHC-restricted manner. The onset of gene expression was rapid (within 30 min) and durable (up to 7 days postelectroporation) using both GFP and TCR-mediated recognition of target cells. There was no adverse effect observed on the T lymphocytes subjected to RNA electroporation evaluated by cell growth rate, annexin-V staining of apoptotic cells, BrdU incorporation, tumor antigen-specific recognition or antigen-specific TCR affinity. The results of this study indicate that mRNA electroporation provides a powerful tool to introduce genes into both human and murine primary T lymphocytes. JF - Molecular therapy : the journal of the American Society of Gene Therapy AU - Zhao, Yangbing AU - Zheng, Zhili AU - Cohen, Cyrille J AU - Gattinoni, Luca AU - Palmer, Douglas C AU - Restifo, Nicholas P AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 151 EP - 159 VL - 13 IS - 1 SN - 1525-0016, 1525-0016 KW - Antigens, Neoplasm KW - 0 KW - CTAG1B protein, human KW - MART-1 Antigen KW - MLANA protein, human KW - Membrane Proteins KW - Mlana protein, mouse KW - Neoplasm Proteins KW - RNA, Messenger KW - Receptors, Antigen, T-Cell KW - Tumor Suppressor Protein p53 KW - L-Selectin KW - 126880-86-2 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Apoptosis KW - Electroporation KW - Spleen -- cytology KW - Membrane Proteins -- metabolism KW - Humans KW - Receptors, Antigen, T-Cell -- biosynthesis KW - Mice KW - Cell Proliferation KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Survival KW - Green Fluorescent Proteins -- genetics KW - L-Selectin -- genetics KW - Green Fluorescent Proteins -- biosynthesis KW - Cells, Cultured KW - Antigens, Neoplasm -- metabolism KW - Receptors, Antigen, T-Cell -- genetics KW - Neoplasm Proteins -- metabolism KW - T-Lymphocytes -- metabolism KW - T-Lymphocytes -- cytology KW - Transfection KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67573209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.atitle=High-efficiency+transfection+of+primary+human+and+mouse+T+lymphocytes+using+RNA+electroporation.&rft.au=Zhao%2C+Yangbing%3BZheng%2C+Zhili%3BCohen%2C+Cyrille+J%3BGattinoni%2C+Luca%3BPalmer%2C+Douglas+C%3BRestifo%2C+Nicholas+P%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Zhao&rft.aufirst=Yangbing&rft.date=2006-01-01&rft.volume=13&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.issn=15250016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 2005 Jun;115(6):1616-26 [15931392] Gene Ther. 1997 Apr;4(4):296-302 [9176514] J Exp Med. 2004 Dec 6;200(11):1407-17 [15583014] Hum Gene Ther. 1997 Mar 20;8(5):555-61 [9095407] Gene Ther. 1996 Aug;3(8):695-705 [8854095] Nature. 1996 Apr 25;380(6576):720-3 [8614468] Gene Ther. 2000 Apr;7(7):596-604 [10819575] Gene Ther. 2000 Aug;7(16):1431-7 [10981672] Blood. 2001 Jul 1;98(1):49-56 [11418462] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8732-7 [11447288] Blood. 2001 Aug 1;98(3):597-603 [11468156] Nat Med. 2001 Oct;7(10):1155-8 [11590441] Science. 2001 Nov 23;294(5547):1638-42 [11721029] Nature. 2002 Jul 11;418(6894):252-8 [12110902] Science. 2002 Oct 25;298(5594):850-4 [12242449] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16168-73 [12427970] J Immunother. 2003 May-Jun;26(3):190-201 [12806273] Cytotherapy. 2003;5(3):208-10 [12850788] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] J Immunol. 2003 Sep 15;171(6):3287-95 [12960359] J Exp Med. 2003 Sep 15;198(6):947-55 [12963692] J Immunol Methods. 2003 Nov;282(1-2):93-102 [14604544] Blood. 2003 Dec 1;102(12):4137-42 [12920018] J Immunol. 2004 Jan 1;172(1):114-22 [14688316] Mol Ther. 2004 Feb;9(2):241-8 [14759808] J Immunol. 2004 Sep 1;173(5):3002-12 [15322159] Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14639-45 [15381769] Leukemia. 2004 Nov;18(11):1898-902 [15385941] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):11993-7 [8618830] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - United States Physicians' Understanding of Race, Ethnicity and Genetics T2 - International Sociological Association AN - 61793589; 2006S00339 AB - The sequencing of the human genome has provided researchers a better understanding of the complex relationship between our socio-political constructs of race & ethnicity, human genetic variation & disease susceptibility. As we move towards an era of personalized medicine where health care services is focused on the interaction of individualized genomic profile & environmental factors, race & ethnicity continue to serve as proxies. To deepen our understanding of physicians' beliefs about the biological & genetic differences based upon their patients' race & ethnicity, their knowledge of human genetic variation, & their use of these constructs in clinical decision making, we will present qualitative data from the 'Physicians Understanding of Human Genetic Variation' study. The study participants are United States general internists who self identify as either Black or White from five urban areas of the United States. Discussion questions include: How do physicians define race & ethnicity? To what extent does patient's skin-color influence physicians' perception of genetic risk? What knowledge do physicians have of the current science of human genetic variation? These findings have implications in several aspects of health care systems & research endeavors to improve the delivery of quality health care services across the globe. JF - International Sociological Association AU - Bonham, Vence AU - Sellers, Sherrill AU - Odunlami, Adebola AU - Phillips, Elizabeth Y1 - 2006///0, PY - 2006 DA - 0, 2006 KW - Genetics KW - Biological Factors KW - Classification KW - Ethnic Groups KW - Race KW - Scientific Knowledge KW - Beliefs KW - proceeding KW - 1734: sociology of science; sociology of science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61793589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=United+States+Physicians%27+Understanding+of+Race%2C+Ethnicity+and+Genetics&rft.au=Bonham%2C+Vence%3BSellers%2C+Sherrill%3BOdunlami%2C+Adebola%3BPhillips%2C+Elizabeth&rft.aulast=Bonham&rft.aufirst=Vence&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-07-09 N1 - Publication note - 2006 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Spending of Remuneration by Subjects in Non-Treatment Drug Abuse Research Studies AN - 61390161; 200702601 AB - Background: This study examines remuneration spending by drug-using participants in residential drug abuse research. Methods: Ninety-four adult males who participated in residential, non-treatment drug abuse research studies earned remuneration based on length of stay and specific research procedures. Remuneration could be in cash after discharge or for in-kind purchases and bill payments. Spending of remuneration was extracted from charts and evaluated with multivariate analyses. Results: Participants received average remuneration of $1,454, taking 59% in cash. Other categories included cigarettes (60.6% of subjects), toiletries (60.6%), clothing (54.3%), and housing (52.1%). Primary drug of abuse, total remuneration, monthly income, length of stay on the residential research unit, age, and education were significantly associated with in-kind remuneration choices. Less total remuneration, intoxication in the month prior to study, higher IQ, and non-white race were associated with taking more in cash. Conclusion: Residential drug abuse research participants prefer cash to in-kind research remuneration, and their choices reflected drug use and economic status. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Kurlander, Jacob E AU - Simon-Dack, Stephanie L AU - Gorelick, David A AD - NIDA Intramural Research Program, Baltimore E-mail: dgorelic@intra.nida.nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 527 EP - 540 PB - Taylor & Francis Inc., Philadelphia, PA VL - 32 IS - 4 SN - 0095-2990, 0095-2990 KW - Drug abuse, in-kind, motivation, payment, research, subjects KW - Substance Abuse KW - Housing KW - Payments KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61390161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Spending+of+Remuneration+by+Subjects+in+Non-Treatment+Drug+Abuse+Research+Studies&rft.au=Kurlander%2C+Jacob+E%3BSimon-Dack%2C+Stephanie+L%3BGorelick%2C+David+A&rft.aulast=Kurlander&rft.aufirst=Jacob&rft.date=2006-01-01&rft.volume=32&rft.issue=4&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.1080%2F00952990600919427 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-06-04 N1 - Number of references - 16 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Drug Abuse; Housing; Substance Abuse; Payments DO - http://dx.doi.org/10.1080/00952990600919427 ER - TY - JOUR T1 - Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV/AIDS AN - 61384958; 200700517 AB - This article is a review of some of the major epidemiological, behavioral, biological, & integrative prevention research issues & priorities in the area of HIV/AIDS & alcohol consumption. Drinking alcohol increases both the risk for infection with HIV & related illnesses & the morbidity & mortality of patients who progress to AIDS. New & improved measurement procedures have helped in assessment of the complex patterns of alcohol use, identification of intervening explanatory mechanisms for risk behaviors & contexts, & determination of intervention outcomes. Both the direct & indirect effects of alcohol misuse appear to be major contributors to both the risk for infection with HIV & the transmission of HIV/AIDS at the individual & population levels. There is increasing evidence that perhaps no level of alcohol consumption is "safe" for those who are HIV infected & receiving antiretroviral treatment. Interdisciplinary basic behavioral & biomedical research is needed to develop comprehensive culturally appropriate strategies for programs that can be effectively delivered in community contexts in the United States & abroad & that focus on the integration of our understanding of individual behaviors, high-risk group membership, biological mechanisms, & the social & physical environments that place individuals at risk for HIV infection. High-priority topics include improving adherence to antiretroviral medications, prevention of infection in young minority women in the United States, & treatment of HIV+ pregnant women who are alcohol abusers to prevent adverse fetal outcomes, which is an international focus in under-resourced settings in Africa. Figures, References. Adapted from the source document. JF - Substance Use & Misuse AU - Bryant, Kendall J AD - National Instit Alcohol Abuse & Alcoholism, Rockville, MD kbryant@mail.nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 1465 EP - 1507 PB - Taylor & Francis, Philadelphia PA VL - 41 IS - 10-12 SN - 1082-6084, 1082-6084 KW - AIDS KW - alcohol consumption KW - alcohol misuse KW - at risk KW - behavior KW - CNS KW - HIV KW - immune KW - Risk KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Medications KW - Drinking Behavior KW - United States of America KW - Intervention KW - Treatment KW - Morbidity KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61384958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Expanding+Research+on+the+Role+of+Alcohol+Consumption+and+Related+Risks+in+the+Prevention+and+Treatment+of+HIV%2FAIDS&rft.au=Bryant%2C+Kendall+J&rft.aulast=Bryant&rft.aufirst=Kendall&rft.date=2006-01-01&rft.volume=41&rft.issue=10-12&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080600846250 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Drinking Behavior; Prevention; Risk; Intervention; Treatment; Medications; United States of America; Morbidity DO - http://dx.doi.org/10.1080/10826080600846250 ER - TY - JOUR T1 - Prospective Identification of Pregnant Women Drinking Four or More Standard Drinks (>_48 g) of Alcohol Per Day AN - 61377968; 200604137 AB - We aimed to identify drinking rates in a prospectively identified cohort of pregnant women, & subsequently, to identify the drinkers of 48 g or more alcohol/day among them, by using complementary methods for verifying self-reported drinking habits. A research team of social workers & health professionals at the Maipu Clinic, located in a lower middle class neighborhood of Santiago, Chile, conducted interviews of women attending a prenatal clinic between August 1995 & July 2000. Women whose interview responses met predefined criteria (identified in the text) were further evaluated by home visits. We interviewed 9,628 of 10,917 (88%) women receiving prenatal care. By initial interview, 42.6% of women reported no drinking, 57.4% some alcohol consumption, & 3.7% consuming at least one standard drink (15 mL of absolute alcohol) per day. Of the 887 women who had home visits, 101 were identified as consuming on average at least 4 drinks/day (48 g). To determine the best home visit questionnaire items for identifying those drinking at least 4 drinks per day, 48 women who openly admitted drinking this amount were compared with 786 women who were not considered drinkers after the home visit. The 48 self-reported 48 g/day drinkers were significantly more likely to get tipsy when drinking before (p = 0.01) or during (p < 0.0001) pregnancy, to have started drinking at a younger age (p = 0.007), or to exhibit signs of low self-esteem (p < 0.0001), sleep or appetite problems (p < 0.0001), bad interpersonal relationships (p < 0.0001) or having family members with fetal alcohol syndrome features (p < 0.009). In conclusion, using complementary methods of alcohol misuse ascertainment during pregnancy, we found that at least 1% of pregnant women in a Santiago, Chile, clinic population were drinking at levels that are clearly dangerous to the fetus (48 g/day or more). We identified specific interview questions that may help screen for alcohol use of 48 g/day or more in pregnant women. Tables, Figures, References. Adapted from the source document. JF - Substance Use & Misuse AU - Aros, Sofia AU - Mills, James L AU - Torres, Claudia AU - Henriquez, Cecilia AU - Fuentes, Ariel AU - Capurro, Teresa AU - Mena, Maria AU - Conley, Mary AU - Cox, Christopher AU - Signore, Caroline AU - Klebanoff, Mark AU - Cassorla, Fernando AD - c/o Mills -- Dept Health & Human Services, National Instits Health, Bethesda, MD Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 183 EP - 197 PB - Taylor & Francis, Philadelphia PA VL - 41 IS - 2 SN - 1082-6084, 1082-6084 KW - fetal alcohol syndrome KW - screening KW - alcohol pregnancy KW - alcoholism KW - risk KW - Risk KW - Alcoholism KW - Pregnancy KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61377968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Prospective+Identification+of+Pregnant+Women+Drinking+Four+or+More+Standard+Drinks+%28%26gt%3B_48+g%29+of+Alcohol+Per+Day&rft.au=Aros%2C+Sofia%3BMills%2C+James+L%3BTorres%2C+Claudia%3BHenriquez%2C+Cecilia%3BFuentes%2C+Ariel%3BCapurro%2C+Teresa%3BMena%2C+Maria%3BConley%2C+Mary%3BCox%2C+Christopher%3BSignore%2C+Caroline%3BKlebanoff%2C+Mark%3BCassorla%2C+Fernando&rft.aulast=Aros&rft.aufirst=Sofia&rft.date=2006-01-01&rft.volume=41&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080500391779 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Alcoholism; Pregnancy; Risk DO - http://dx.doi.org/10.1080/10826080500391779 ER - TY - JOUR T1 - e-miles to go and promises to keep. AN - 57690798; 00505181 AB - Though libraries are by no means abandoning print collections, librarians continue to experience the effects of a divided reality as access for text and image materials shifts from print to digital. It is not information as much as the uniqueness of information in book form that needs to he promoted. Librarians, aware of their obligation to provide responsible custody for legacy collections, have an opportunity to restore this experience to the information landscape as they reconfigure their institutions to capitalize on the access benefits of new technologies. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). (Author abstract) JF - Collection Management AU - Cybulski, Walter AD - Quality Assurance Unit, Preservation and Collection Management Section, U.S. National Library of Medicine in Bethesda, 8600 Rockville Pike, Bethesda, MD 20894 cybulskw@mail.nlm.nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 57 EP - 73 PB - Haworth Press Inc VL - 31 IS - 1-2 SN - 0146-2679, 0146-2679 KW - Collection development KW - Printed materials KW - Preservation KW - 9.15: TECHNICAL SERVICES - PRESERVATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57690798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Collection+Management&rft.atitle=e-miles+to+go+and+promises+to+keep.&rft.au=Cybulski%2C+Walter&rft.aulast=Cybulski&rft.aufirst=Walter&rft.date=2006-01-01&rft.volume=31&rft.issue=1-2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Collection+Management&rft.issn=01462679&rft_id=info:doi/10.1300%2FJ105v31n01_04 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Preservation; Printed materials; Collection development DO - http://dx.doi.org/10.1300/J105v31n01_04 ER - TY - JOUR T1 - Information Rx: evaluation of a new informatics tool for physicians, patients, and libraries. AN - 57674217; 477381 AB - This paper reports selected results from two comprehensive evaluation studies of the Information Prescription (or "Information Rx") Program implementation conducted from 2002-05 by the American College of Physicians Foundation (ACPF) and the U.S. National Library of Medicine (NLM). In this Program physicians are provided with Information Prescription pads, analogous to pads used to prescribe medications, that are used to direct patients to the MedlinePlus web site and its contents that are applicable to a patient's health condition. The results describe the Program's potential to enhance patient education and interpersonal communication from physician and patient perspectives. The findings suggest once physicians adopt the use of an information prescription, they perceive they are providing an additional clinical service that enhances patient education and interpersonal communication. For physicians, participation in information prescription may improve patient communication, encourage information seeking, and lessen the number of poor quality Internet searches that patients frequently self-perform and bring to a doctor's office. Similarly, once patients receive a recommendation from a physician to seek health information on the web, patients may be more comfortable with health seeking on the Internet and discussing their findings with their doctor. The conclusions of the two evaluation studies imply an Information Prescription fosters a dialogue between providers and patients, helps patients use the Internet more effectively and seems to favorably impact patient education. As the medical community and patient advocacy groups continue to emphasize the importance of evidence-based information as the gold standard for accepted care, it can be expected that informatics tools such as Information Rx will come to play an increasingly important role as a vehicle to help identify and access high quality health information on the Internet. (Author abstract) JF - Information Services & Use AU - Siegel, Elliot R AU - Logan, Robert A AU - Harnsberger, Robert L AU - Cravedi, Kathleen AU - Krause, Jean A AU - Lyon, Becky AU - Hajarian, Karen AU - Uhl, Jonathan AU - Ruffin, Angela AU - Lindberg, Donald A B AD - U.S. National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20894, USA Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 1 EP - 10 PB - IOS Press VL - 26 IS - 1 SN - 0167-5265, 0167-5265 KW - Evaluation KW - Software KW - USA KW - Medical informatics KW - Doctor-patient communication KW - 10.13: SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57674217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Services+%26+Use&rft.atitle=Information+Rx%3A+evaluation+of+a+new+informatics+tool+for+physicians%2C+patients%2C+and+libraries.&rft.au=Siegel%2C+Elliot+R%3BLogan%2C+Robert+A%3BHarnsberger%2C+Robert+L%3BCravedi%2C+Kathleen%3BKrause%2C+Jean+A%3BLyon%2C+Becky%3BHajarian%2C+Karen%3BUhl%2C+Jonathan%3BRuffin%2C+Angela%3BLindberg%2C+Donald+A+B&rft.aulast=Siegel&rft.aufirst=Elliot&rft.date=2006-01-01&rft.volume=26&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Information+Services+%26+Use&rft.issn=01675265&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical informatics; Doctor-patient communication; Software; Evaluation; USA ER - TY - JOUR T1 - Person-Factors in the California Adult Q-Set: Closing the Door on Personality Trait Types? AN - 57169960; 200607037 AB - To investigate recent hypotheses of replicable personality types, we examined data from 1540 self-sorts on the California Adult Q-Set (CAQ). Conventional factor analysis of the items showed the expected Five-Factor Model (FFM). Inverse factor analysis across random subsamples showed that none of the previously reported person-factors were replicated. Only two factors were replicable, &, most importantly, these factors were contaminated by mean level differences in item endorsement. Results were not due to sample size or age heterogeneity. Subsequent inverse factor analysis of standardized items revealed at least three replicable factors; when five person-factors were extracted, they could be aligned precisely with the dimensions of the FFM. The major factors of person similarity can be accounted for entirely in terms of the FFM, consistent with the hypothesis that there are no replicable personality types in the CAQ. Comments made by Jens Asendorpf. Respnses made by Robert McCrae, Antonio Terracciano, Paul Costa and Daniel Ozer. 7 Tables, 41 References. [Copyright 2006 John Wiley and Sons, Ltd.] JF - European Journal of Personality AU - McCrae, Robert R AU - Terracciano, Antonio AU - Costa, Paul T, Jr AU - Ozer, Daniel J AD - Gerontology Research Center, National Instit Aging, Baltimore, MD mccraej@grc.nia.nih.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 29 EP - 44 PB - John Wiley & Sons, Chichester UK VL - 20 IS - 1 SN - 0890-2070, 0890-2070 KW - Replication studies KW - Person concept KW - Factor analysis KW - Personality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57169960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Personality&rft.atitle=Person-Factors+in+the+California+Adult+Q-Set%3A+Closing+the+Door+on+Personality+Trait+Types%3F&rft.au=McCrae%2C+Robert+R%3BTerracciano%2C+Antonio%3BCosta%2C+Paul+T%2C+Jr%3BOzer%2C+Daniel+J&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Personality&rft.issn=08902070&rft_id=info:doi/10.1002%2Fper.553 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - EJPEEU N1 - SubjectsTermNotLitGenreText - Personality; Person concept; Replication studies; Factor analysis DO - http://dx.doi.org/10.1002/per.553 ER - TY - JOUR T1 - Comments by Richard A. Denisco AN - 57154703; 200708863 AB - A comment on Mark Gold et al's article on fentanyl abuse & dependence (2006) applauds their suggestion that a neurobiological etiology may explain the high level of substance abuse among anesthesiologists. However, the assertion that the highest concentrations of fentanyl & propofol gases were found close to the patient's mouth needs clarification, especially in relation to patients who are intubated. There is also a need for further research on the transdermal absorption of fentanyl. References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Addictive Diseases AU - Denisco, Richard A AD - Division Epidemiology/Services/Prevention Research, National Instit Drug Abuse, Bethesda, MD deniscor@nida.nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 137 PB - Haworth Press, Binghamton NY VL - 25 IS - 4 SN - 1055-0887, 1055-0887 KW - Doctors KW - Addiction KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57154703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Comments+by+Richard+A.+Denisco&rft.au=Denisco%2C+Richard+A&rft.aulast=Denisco&rft.aufirst=Richard&rft.date=2006-01-01&rft.volume=25&rft.issue=4&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v25n04_15 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Doctors; Substance abuse; Addiction DO - http://dx.doi.org/10.1300/J069v25n04_15 ER - TY - JOUR T1 - The Participation of Disabled Women in the Rules of Niddah AN - 57151427; 200712233 AB - In Jewish Law (Halachah) a woman is in the state of niddah after uterine bleeding. This short paper explains the laws concerning niddah and also aspects involving the women with disability. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Religion, Disability & Health AU - Zimmerman, Deena R AD - National Institute of Child Health and Human Development, Saban Children's Medical Center, Soroka University Medical Center, Beer Sheva, Israel E-mail: yoatzothalacha@nishmat.net Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 217 EP - 220 PB - Haworth Press, Binghamton NY VL - 10 IS - 3-4 SN - 1522-8967, 1522-8967 KW - Disability, women, Jewish law, niddah, Israel KW - Religious customs KW - Social participation KW - Law KW - Judaism KW - Disabled women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57151427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Religion%2C+Disability+%26+Health&rft.atitle=The+Participation+of+Disabled+Women+in+the+Rules+of+Niddah&rft.au=Zimmerman%2C+Deena+R&rft.aulast=Zimmerman&rft.aufirst=Deena&rft.date=2006-01-01&rft.volume=10&rft.issue=3-4&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Religion%2C+Disability+%26+Health&rft.issn=15228967&rft_id=info:doi/10.1300%2FJ095v10n03_13 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Disabled women; Religious customs; Social participation; Judaism; Law DO - http://dx.doi.org/10.1300/J095v10n03_13 ER - TY - JOUR T1 - Infant-Mother Attachment Classification: Risk and Protection in Relation to Changing Maternal Caregiving Quality AN - 57053867; 200615189 AB - The relations between early infant-mother attachment & children's social competence & behavior problems during the preschool & early school-age period were examined in more than 1,000 children under conditions of decreasing, stable, & increasing maternal parenting quality. Infants' Strange Situation attachment classifications predicted mothers' reports of children's social competence & teachers' reports of externalizing & internalizing behaviors from preschool age through 1st grade. These relations appeared to be mediated by parenting quality; main effects of attachment classification disappeared when effects of parenting quality were controlled. Interactions were also observed. For example, when parenting quality improved over time, teachers rated children with insecure infant-mother attachments lower on externalizing behaviors; when parenting quality decreased, teachers rated insecure children higher on externalizing behaviors. In contrast, children classified as securely attached in infancy did not appear to be affected by declining or improving parenting quality. 7 Tables, 3 Figures, 79 References. [Copyright 2006 American Psychological Association] JF - Developmental Psychology AU - NICHD Early Child Care Research Network AD - NICHD Early Child Care Research Network; NICHD Early Child Care Research Network, Rockville, MD Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 38 EP - 58 PB - American Psychological Association, Washington DC VL - 42 IS - 1 SN - 0012-1649, 0012-1649 KW - early attachment security, risks and protection, behavior problems in preschoolers, maternal sensitivity, continuity from infancy to preschool KW - Quality of care KW - Attachment KW - Carers KW - Infants KW - Parent-Child interactions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57053867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Psychology&rft.atitle=Infant-Mother+Attachment+Classification%3A+Risk+and+Protection+in+Relation+to+Changing+Maternal+Caregiving+Quality&rft.au=NICHD+Early+Child+Care+Research+Network&rft.aulast=NICHD+Early+Child+Care+Research+Network&rft.aufirst=&rft.date=2006-01-01&rft.volume=42&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Developmental+Psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.42.1.38 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - DEVPA9 N1 - SubjectsTermNotLitGenreText - Parent-Child interactions; Attachment; Infants; Carers; Quality of care DO - http://dx.doi.org/10.1037/0012-1649.42.1.38 ER - TY - JOUR T1 - Use of satellite imagery and GIS modeling to derive agricultural chemical exposure metrics for use in human-health studies AN - 51612024; 2006-028033 JF - Scientific Investigations Report AU - Maxwell, Susan AU - Ward, Mary AU - Nuckols, Jay A2 - Char, Stephen J. A2 - Sieverling, Jennifer B. Y1 - 2006 PY - 2006 DA - 2006 SP - 24 EP - 25 PB - U. S. Geological Survey, Reston, VA KW - imagery KW - pollutants KW - pollution KW - epidemiology KW - satellite methods KW - diseases KW - carcinogens KW - geographic information systems KW - agrochemicals KW - information systems KW - applications KW - USGS KW - remote sensing KW - public health KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51612024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+Investigations+Report&rft.atitle=Use+of+satellite+imagery+and+GIS+modeling+to+derive+agricultural+chemical+exposure+metrics+for+use+in+human-health+studies&rft.au=Maxwell%2C+Susan%3BWard%2C+Mary%3BNuckols%2C+Jay&rft.aulast=Maxwell&rft.aufirst=Susan&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Scientific+Investigations+Report&rft.issn=&rft_id=info:doi/ L2 - http://pubs.usgs.gov/sir/2005/5236/ http://pubs.usgs.gov/sir/ LA - English DB - GeoRef N1 - Conference title - U. S. Geological Survey fifth biennial geographic information science workshop N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Last updated - 2012-06-07 N1 - CODEN - #06439 N1 - SubjectsTermNotLitGenreText - agrochemicals; applications; carcinogens; diseases; epidemiology; geographic information systems; imagery; information systems; pollutants; pollution; public health; remote sensing; satellite methods; USGS ER - TY - JOUR T1 - The late Miocene radiation of modern Felidae; a genetic assessment AN - 51599471; 2006-036466 AB - Modern felid species descend from relatively recent (<11 million years ago) divergence and speciation events that produced successful predatory carnivores worldwide but that have confounded taxonomic classifications. A highly resolved molecular phylogeny with divergence dates for all living cat species, derived from autosomal, X-linked, Y-linked, and mitochondrial gene segments (22,789 base pairs) and 16 fossil calibrations define eight principal lineages produced through at least 10 intercontinental migrations facilitated by sea-level fluctuations. A ghost lineage analysis indicates that available felid fossils underestimate (i.e., unrepresented basal branch length) first occurrence by an average of 76%, revealing a low representation of felid lineages in paleontological remains. The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation. JF - Science AU - Johnson, Warren E AU - Eizirik, Eduardo AU - Pecon-Slattery, Jill AU - Murphy, William J AU - Antunes, Agostinho AU - Teeling, Emma AU - O'Brien, Stephen J Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 73 EP - 77 PB - American Association for the Advancement of Science, Washington, DC VL - 311 IS - 5757 SN - 0036-8075, 0036-8075 KW - biogeography KW - modern KW - Cenozoic KW - Theria KW - Panthera KW - Fissipeda KW - Felidae KW - taxonomy KW - Eutheria KW - species diversity KW - Chordata KW - Quaternary KW - phylogeny KW - Carnivora KW - Mammalia KW - biologic evolution KW - molecular biology KW - Miocene KW - genetics KW - Tertiary KW - Neogene KW - DNA KW - upper Miocene KW - Vertebrata KW - adaptive radiation KW - Tetrapoda KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51599471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=The+late+Miocene+radiation+of+modern+Felidae%3B+a+genetic+assessment&rft.au=Johnson%2C+Warren+E%3BEizirik%2C+Eduardo%3BPecon-Slattery%2C+Jill%3BMurphy%2C+William+J%3BAntunes%2C+Agostinho%3BTeeling%2C+Emma%3BO%27Brien%2C+Stephen+J&rft.aulast=Johnson&rft.aufirst=Warren&rft.date=2006-01-01&rft.volume=311&rft.issue=5757&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1122277 L2 - http://www.sciencemag.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 30 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - adaptive radiation; biogeography; biologic evolution; Carnivora; Cenozoic; Chordata; DNA; Eutheria; Felidae; Fissipeda; genetics; Mammalia; Miocene; modern; molecular biology; Neogene; Panthera; phylogeny; Quaternary; species diversity; taxonomy; Tertiary; Tetrapoda; Theria; upper Miocene; Vertebrata DO - http://dx.doi.org/10.1126/science.1122277 ER - TY - JOUR T1 - Measuring agreement between two statistics with applications to age standardization AN - 38216999; 2991988 AB - We detail a general method for measuring agreement between two statistics. An application is two ratios of directly standardized rates which differ only by the choice of the standard. If the statistics have a high value for the coefficient of agreement then the expected squared difference between the statistics is small relative to the variance of the average of the two statistics, and inferences vary little by changing statistics. The estimation of a coefficient of agreement between two statistics is not straightforward because there is only one pair of observed values, each statistic calculated from the data. We introduce estimators of the coefficient of agreement for two statistic and discuss their use, especially as applied to functions of standardized rates. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Fay, M P AU - Lee, J H AD - National Institute of Allergy and Infectious Diseases ; University of South Florida Y1 - 2006 PY - 2006 DA - 2006 SP - 81 EP - 96 VL - 169 IS - 1 SN - 0964-1998, 0964-1998 KW - Sociology KW - Comparative analysis KW - Standardization KW - Age KW - Statistics KW - Statistical analysis KW - Correlation KW - Statistical methods KW - Population statistics KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/38216999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Measuring+agreement+between+two+statistics+with+applications+to+age+standardization&rft.au=Fay%2C+M+P%3BLee%2C+J+H&rft.aulast=Fay&rft.aufirst=M&rft.date=2006-01-01&rft.volume=169&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 12233; 7994; 2630 971; 12164 10529; 9879 12233; 646; 2904 12224 971 ER - TY - JOUR T1 - Analysing survey data with incomplete responses by using a method based on empirical likelihood AN - 37735851; 3263223 AB - In many surveys, missing response is a common problem. As an example, Zahner, Jacobs, Freeman and Trainor analysed data from a study of child psychopathology in the State of Connecticut, USA. In that study, the response variable, psychopathology, was inferred from questions that were addressed to teachers of the children and was subject to a high level of missingness. However, the missing responses were supplemented by surrogate information that was provided by the parents and/or the primary care providers of the children. In such a situation, it is conceivable that the supplemental information can be used to recover some of the information that has been lost in the cases with missing response. This paper considers a method using empirical likelihood. Empirical likelihood is well known in providing nonparametric inference. But its application has largely been confined to complete-data situations. The method proposed exploits the semiparametric nature of empirical likelihood. The method gives consistent estimates if the cases with non-missing responses form a random sample of the population. In large samples, the method behaves similarly to a regression estimate that is applied to estimating equations. The method is easy to implement with standard statistical packages. In a small sample study, the method was found to give favourable results, when compared with existing methods. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Leung, D.H.Y. AU - Qin, J AD - Singapore Management University ; National Institute of Allergy and Infectious Diseases Y1 - 2006 PY - 2006 DA - 2006 SP - 379 EP - 396 VL - 55 IS - 3 SN - 0035-9254, 0035-9254 KW - Sociology KW - Data collection KW - Survey data KW - Statistical models KW - Maximum likelihood method KW - Empirical research KW - Data analysis KW - Statistical methods KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37735851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Analysing+survey+data+with+incomplete+responses+by+using+a+method+based+on+empirical+likelihood&rft.au=Leung%2C+D.H.Y.%3BQin%2C+J&rft.aulast=Leung&rft.aufirst=D.H.Y.&rft.date=2006-01-01&rft.volume=55&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 3279 971 3286; 3286; 12427 12429; 4200 10902; 7994; 7837 8160 8163 12230 ER - TY - JOUR T1 - Genetic susceptibility testing from a stress and coping perspective AN - 37718556; 3263675 JF - Social science and medicine AU - Gooding, Holly C AU - Organista, Kurt AU - Burack, Jeffrey AU - Biesecker, Barbara Bowles AD - University of California ; NHRGI/National Institutes of Health Y1 - 2006 PY - 2006 DA - 2006 SP - 1880 EP - 1890 VL - 62 IS - 8 SN - 0277-9536, 0277-9536 KW - Sociology KW - Anthropology KW - Forecasts KW - Genetics KW - Mental stress KW - Health KW - Medicine KW - Diseases KW - Human behaviour KW - Social sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37718556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Genetic+susceptibility+testing+from+a+stress+and+coping+perspective&rft.au=Gooding%2C+Holly+C%3BOrganista%2C+Kurt%3BBurack%2C+Jeffrey%3BBiesecker%2C+Barbara+Bowles&rft.aulast=Gooding&rft.aufirst=Holly&rft.date=2006-01-01&rft.volume=62&rft.issue=8&rft.spage=1880&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.08.041 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11920; 7894; 7953 7954; 5460 1615 8573 11325; 5772; 3617 6220; 5163; 6071 1542 11325 DO - http://dx.doi.org/10.1016/j.socscimed.2005.08.041 ER - TY - JOUR T1 - Environmental control, social context, and individual differences in behavioral and cortisol responses to novelty in infant rhesus monkeys AN - 37718486; 3251980 AB - The effects of appetitive controllability on behavioral and cortisol reactivity to novelty in 12 infant rhesus monkeys were studied. Surrogate-peer-reared infants had homecage access to food treats contingently via lever pressing ('master') or noncontingently ('yoked') for 12 weeks from postnatal month 2. Masters lever-pressed more, but did not differ in baseline cortisol. At month 5, infants were exposed to a novel environment in social groups and individually. Masters were significantly more active and exhibited significantly lower cortisol reactivity to the novel environment, but only in the individual context. Also, individual differences in operant behavior were positively correlated with behavioral activity and negatively correlated with cortisol reactivity to the novel environment. The results reveal context-specific benefits of contingent stimulation in infancy. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Roma, Peter G AU - Champoux, Maribeth AU - Suomi, Stephen J AD - National Institute of Child Health and Human Development Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 118 EP - 131 VL - 77 IS - 1 SN - 0009-3920, 0009-3920 KW - Sociology KW - Scientific research KW - Infancy KW - Social environment KW - Animal behaviour KW - Hormones KW - Primates KW - Individuality KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37718486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Environmental+control%2C+social+context%2C+and+individual+differences+in+behavioral+and+cortisol+responses+to+novelty+in+infant+rhesus+monkeys&rft.au=Roma%2C+Peter+G%3BChampoux%2C+Maribeth%3BSuomi%2C+Stephen+J&rft.aulast=Roma&rft.aufirst=Peter&rft.date=2006-01-01&rft.volume=77&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 11829 6077 4309; 6329 6085; 10148; 5983 9524 1615 8573 11325; 6490 2211 652 5676 646 6091 2212; 11347 10902; 1025 1542 11325 ER - TY - JOUR T1 - Age changes in personality and their origins: comment on Roberts, Walton, and Viechtbauer (2006) AN - 37706695; 3250593 AB - Although B. W. Roberts, K. W. Walton, and W. Viechtbauer (2006) depicted the present authors as proponents of the immutability of traits, in fact we have always acknowledged the possibility of change, and we are pleased that the results of their meta-analysis are consistent with our conclusions about modest change after age 30. We agree with B.W. Roberts et al. that analyses should be conducted at the level of more specific traits, but prefer the 30 facets of the Revised NEO Personality Inventory to the Social Dominance-Social Vitality distinction. The origins of age changes might be found either in environmental influences common to all cultures or in biologically based intrinsic maturation; we offer some reasons for preferring the latter interpretation. Meta-analyses are useful but not definitive, and the resolution of the origin question lies in further research. Reprinted by permission of the American Psychological Association JF - Psychological bulletin AU - Costa, Jr., Paul T. AU - McCrae, Robert R AD - National Institute on Aging Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 26 EP - 28 VL - 132 IS - 1 SN - 0033-2909, 0033-2909 KW - Sociology KW - Psychology KW - Factor analysis KW - Personality change KW - Maturity KW - Data analysis KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37706695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+bulletin&rft.atitle=Age+changes+in+personality+and+their+origins%3A+comment+on+Roberts%2C+Walton%2C+and+Viechtbauer+%282006%29&rft.au=Costa%2C+Jr.%2C+Paul+T.%3BMcCrae%2C+Robert+R&rft.aulast=Costa&rft.aufirst=Jr.&rft.date=2006-01-01&rft.volume=132&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Psychological+bulletin&rft.issn=00332909&rft_id=info:doi/10.1037%2F003-2909.132.1.26 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - This is a comment on 'Patterns of mean-level change in personality traits across the life course: a meta-analysis of longitudinal studies' which appeared in Psychological Bulletin, 132:1 January 2006 by Brent W. Roberts, Kate E. Walton and Wolfgang Viechtbauer N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3279 971 3286; 4722 12224 971; 7834 646; 4562; 9418 9416 2153; 10404 DO - http://dx.doi.org/10.1037/003-2909.132.1.26 ER - TY - JOUR T1 - Tests for a simple tree order restriction with application to dose-response studies AN - 36493799; 3302413 AB - We propose 'Dunnett-type' test procedures to test for simple tree order restrictions on the means of p independent normal populations. The new tests are based on the estimation procedures that were introduction by Hwang and Peddada and later by Dunbar, Conaway and Peddada. The procedures proposed are also extended to test for 'two-sided' simple tree order restrictions. For non-normal data, nonparametric versions based on ranked data are also suggested. Using computer simulations, we compare the proposed test procedures with some existing test procedures in terms of size and power. Our simulations study suggests that the procedures compete well with the existing procedures for both one-sided and two-sided simple tree alternatives. In some instances, especially in the case of two-sided alternatives or for non-normally distributed data, the gains in power due to the procedures proposed can be substantial. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Peddada, S D AU - Haseman, J K AU - Tan, X AU - Travlos, G AD - National Institute of Environmental Health Sciences ; PICC Life Insurance Company Ltd, Beijing Y1 - 2006 PY - 2006 DA - 2006 SP - 493 EP - 506 VL - 55 IS - 4 SN - 0035-9254, 0035-9254 KW - Sociology KW - Medical research KW - Statistical models KW - Statistical methods KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36493799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Tests+for+a+simple+tree+order+restriction+with+application+to+dose-response+studies&rft.au=Peddada%2C+S+D%3BHaseman%2C+J+K%3BTan%2C+X%3BTravlos%2C+G&rft.aulast=Peddada&rft.aufirst=S&rft.date=2006-01-01&rft.volume=55&rft.issue=4&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 7886 10902; 7994 ER - TY - JOUR T1 - Cancer knowledge and disparities in the information age AN - 36481376; 3343798 AB - Increasing information flow often leads to widening gaps in knowledge between different socioeconomic status (SES) groups as higher SES groups are more likely to acquire this new information at a faster rate than lower SES groups. These gaps in knowledge may offer a partial but robust explanation for differential risk behaviors and health disparities between different social groups. Drawing on the Health Information National Trends Survey (HINTS 2003), a national survey of communication behaviors conducted by the National Cancer Institute (NCI), we examine the relationship between publicity and knowledge gaps on two cancer topics that received different levels of publicity: knowledge about tobacco and sun exposure and their respective links to cancer. Analyses of the HINTS 2003 data suggest that differential knowledge levels of causes of cancer between SES groups are one potential explanation of cancer disparities that have been extensively reported in the literature. It is evident that high income and high education are associated with awareness about causes of major cancers such as lung and skin, and may allow people to protect themselves and minimize their risks. The data also show that heavier media attention could attenuate the knowledge gaps though moderate publicity or lack of news coverage may actually widen them. Last, the findings in this article suggest that it is necessary to take into account the SES variation within different racial and ethnic groups rather than mask them by treating the groups as one. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Viswanath, K AU - Breen, Nancy AU - Meissner, Helen AU - Moser, Richard P AU - Hesse, Bradford AU - Steele, Whitney Randolph AU - Rakowski, William AD - Harvard University ; National Cancer Institute ; Brown University Y1 - 2006 PY - 2006 DA - 2006 SP - 1 EP - 17 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Inequality KW - Information dissemination KW - Knowledge KW - Cancer KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36481376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Cancer+knowledge+and+disparities+in+the+information+age&rft.au=Viswanath%2C+K%3BBreen%2C+Nancy%3BMeissner%2C+Helen%3BMoser%2C+Richard+P%3BHesse%2C+Bradford%3BSteele%2C+Whitney+Randolph%3BRakowski%2C+William&rft.aulast=Viswanath&rft.aufirst=K&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730600637426 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 7073; 6489; 6520; 5790 5772 DO - http://dx.doi.org/10.1080/10810730600637426 ER - TY - JOUR T1 - Cancer-related information seeking: hints from the 2003 Health Information National Trends Survey (HINTS) AN - 36480230; 3343807 AB - Few nationally representative surveys have assessed the cancer-related information seeking behavior of the American public. Data for our analysis were from the 2003 Health Information National Trends Survey (HINTS). The goals of our analysis were to characterize cancer information seekers (3,011) and nonseekers (3,348) in terms of sociodemographic, health care access, and health status variables, and to describe the nature of the cancer-related information being sought by information seekers. Significant and independent associations with seeking status were identified for gender, age, race, income, education, personal and family history of cancer, and having a usual source of health care. Information seekers were less likely to be male (OR = .51); aged 65 or older (OR = .40); Hispanic (OR = .60); to have a usual source of health care (OR = .70); and more likely to have incomes greater than $50,000 (OR = 1.50), some college (OR = 1.87) or a college degree (OR = 2.95), a prior cancer diagnosis (OR = 3.57), or a family history of cancer (OR = 2.17). Among cancer information seekers, the most frequently searched topic was cancer site-specific information (50.2%). Individuals who reported searching for cancer site-specific information were most frequently looking for information about breast cancer (23.8%), prostate cancer (11.5%), and skin cancer (11.3%). The HINTS Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Rutten, Lila J. Finney AU - Squiers, Linda AU - Hesse, Bradford AD - National Cancer Institute-Frederick ; National Cancer Institute Y1 - 2006 PY - 2006 DA - 2006 SP - 147 EP - 156 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Surveys KW - Information dissemination KW - Cancer KW - Public health KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36480230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Cancer-related+information+seeking%3A+hints+from+the+2003+Health+Information+National+Trends+Survey+%28HINTS%29&rft.au=Rutten%2C+Lila+J.+Finney%3BSquiers%2C+Linda%3BHesse%2C+Bradford&rft.aulast=Rutten&rft.aufirst=Lila+J.&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730600637574 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 6520; 5790 5772; 12429; 10449 5772 DO - http://dx.doi.org/10.1080/10810730600637574 ER - TY - JOUR T1 - The health information national trends survey: research from the baseline AN - 36476616; 3343797 AB - The decades surrounding the turn of the millennium will be remembered as a time of extraordinary opportunity in cancer communication. In 1990, the number of age-adjusted deaths due to cancer in the U.S. population began a slow steady decline after a century of disparaging increase. Reasons for this decline have been attributed to long-awaited successes in primary prevention, especially related to tobacco, and early detection for cervical, breast, prostate, and colorectal cancers, as well as advances in treatment. This was also a time of unparalleled change in the cancer communication environment. Scientific health discoveries escalated with the completion of the Human Genome project in 2003, and penetration of the Internet made health information available directly to consumers. To seize the opportunity afforded by these changes, the National Cancer Institute (NCI) launched the Health Information National Trends Survey (HINTS). Fielded for the first time in 2003, the HINTS is a nationally representative, general population survey of non-institutionalized adults in the United States 18 years and older. This supplement contains a compilation of original research conducted using the data generated by the first administration of the HINTS telephone interviews. Covering topics in cancer knowledge, cancer cognition, risk perception, and information seeking, the articles represent an interdisciplinary view of cancer communication at the turn of the millennium and offer insight into the road ahead. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Hesse, Bradford W AU - Moser, Richard P AU - Rutten, Lila J. Finney AU - Kreps, Gary L AD - National Cancer Institute ; SAIC ; George Mason University Y1 - 2006 PY - 2006 DA - 2006 SP - vii EP - vi0 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Surveys KW - Information dissemination KW - Access to information KW - Cancer KW - Public health KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36476616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=The+health+information+national+trends+survey%3A+research+from+the+baseline&rft.au=Hesse%2C+Bradford+W%3BMoser%2C+Richard+P%3BRutten%2C+Lila+J.+Finney%3BKreps%2C+Gary+L&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=vii&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730600692553 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6520; 1939 3617 6220; 518 6515; 5790 5772; 10449 5772; 12429 DO - http://dx.doi.org/10.1080/10810730600692553 ER - TY - JOUR T1 - Factors associated with patients' perceptions of health care providers' communication behavior AN - 36472255; 3343806 AB - We examined patients' ratings of communication with health care providers by sociodemographic characteristics, health care access, and health status. Data were from a national, population-based survey, the 2003 Health Information National Trends Survey (HINTS). The survey was administered to 6,369 adults from a representative sample of U.S. households. Linear regression analysis was conducted using SUDAAN. None of the sociodemographic variables were significantly associated with patients' ratings of providers' communication behavior in the linear model. Ratings of health care providers' communication behavior, however, were significantly higher among respondents with health insurance (p = 0.007) and those with a usual source of health care from whom they consistently sought care (p < 0.001). Ratings of provider communication were significantly lower among respondents who perceived their general health to be fair or poor (p < 0.001) and among those respondents with greater depressive symptoms (p < 0.001). Differences in patient ratings of health care providers' communication by health care access and health status suggest the potential for disparities in health outcomes. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Rutten, Lila J. Finney AU - Augustson, Erik AU - Wanke, Kay AD - National Cancer Institute-Frederick ; National Cancer Institute, Bethesda Y1 - 2006 PY - 2006 DA - 2006 SP - 135 EP - 146 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Health care KW - Perception KW - Communication KW - Patients KW - Information dissemination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36472255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Factors+associated+with+patients%27+perceptions+of+health+care+providers%27+communication+behavior&rft.au=Rutten%2C+Lila+J.+Finney%3BAugustson%2C+Erik%3BWanke%2C+Kay&rft.aulast=Rutten&rft.aufirst=Lila+J.&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730600639596 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5775 13521; 9271 7890 5792 10484; 6520; 2572; 9382 DO - http://dx.doi.org/10.1080/10810730600639596 ER - TY - JOUR T1 - Perceived ambiguity about cancer prevention recommendations: relationship to perceptions of cancer preventability, risk, and worry AN - 36470766; 3343801 AB - In this study, we apply the concept of 'ambiguity,' as developed in the decision theory literature, to an analysis of potential psychological consequences of uncertainty about cancer prevention recommendations. We used Health Information National Trends Survey (HINTS) 2003 data to examine how perceived ambiguity about cancer prevention recommendations relates to three other cognitive variables known to influence cancer-protective behavior: perceived cancer preventability, perceived cancer risk, and cancer-related worry. Using logistic regression analyses, we tested several predictions derived from a review of literature on the effects of ambiguity perceptions on decision making, cognitions, and emotions. We found perceived ambiguity to have a strong negative relationship with perceived cancer preventability, consistent with 'ambiguity aversion'-a pessimistic bias in the interpretation of ambiguity. Cancer worry moderated this relationship; ambiguity aversion increased with higher levels of worry. At the same time, perceived ambiguity was positively related to both perceived cancer risk and cancer worry. Furthermore, perceived risk partially mediated the relationship between perceived ambiguity and worry. These findings suggest that perceived ambiguity about cancer prevention recommendations may have broad and important effects on other health cognitions. We discuss ethical implications of these findings for health communication efforts, and propose a tentative causal model to guide future research. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Han, Paul K.J. AU - Moser, Richard P AU - Klein, William M.P. AD - National Cancer Institute ; University of Pittsburgh Y1 - 2006 PY - 2006 DA - 2006 SP - 51 EP - 69 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Prevention KW - Information dissemination KW - Access to information KW - Cancer KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36470766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Perceived+ambiguity+about+cancer+prevention+recommendations%3A+relationship+to+perceptions+of+cancer+preventability%2C+risk%2C+and+worry&rft.au=Han%2C+Paul+K.J.%3BMoser%2C+Richard+P%3BKlein%2C+William+M.P.&rft.aulast=Han&rft.aufirst=Paul&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F1081073060063754 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10072; 1939 3617 6220; 6520; 518 6515; 5790 5772 DO - http://dx.doi.org/10.1080/1081073060063754 ER - TY - JOUR T1 - Awareness of the national cancer institute's cancer information service: results from the Health Information National Trends Survey (HINTS) AN - 36467512; 3343805 AB - Established in 1975, the National Cancer Institute's (NCI's) Cancer Information Service (CIS) is a national information and education network that serves the nation by providing the latest scientific cancer information to the American public. The purpose of this study was to determine the public's awareness of the CIS and other national cancer and health organizations by analyzing data from the NCI's Health Information National Trends Survey (HINTS 2003). This study also examined sociodemographic, health, and communication correlates of awareness of CIS and other national health organizations: American Cancer Society (ACS), National Institutes of Health (NIH), and NCI. Results indicated that awareness of the CIS was low (32.8%). Some subgroups were more likely to be aware of the CIS than others. When comparing awareness levels of the four national health organizations, marked differences in patterns of awareness among specific subgroups emerged for many sociodemographic variables. For example, minority groups were significantly more aware of the CIS than Whites; however, for all three other organizations a greater percentage of Whites were aware of each organization. For the NIH, NCI, and ACS, respondents in the highest income group were most aware of each organization and, as income levels increased awareness also increased. The CIS, respondents with the lowest income levels, however, were more aware of the CIS compared with middle- and high-income groups. A similar pattern was found for other sociodemographic variables. Results of this study will guide the development of a targeted promotional campaign for the CIS. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Squiers, Linda AU - Bright, Mary Anne AU - Rutten, Lila J. Finney AU - Atienza, Audie A AU - Treiman, Katherine AU - Moser, Richard P AU - Hesse, Bradford AD - National Cancer Institute ; National Cancer Institute-Frederick ; National Cancer Institute, Bethesda Y1 - 2006 PY - 2006 DA - 2006 SP - 117 EP - 133 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Information dissemination KW - Health services KW - Cancer KW - Public health KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36467512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Awareness+of+the+national+cancer+institute%27s+cancer+information+service%3A+results+from+the+Health+Information+National+Trends+Survey+%28HINTS%29&rft.au=Squiers%2C+Linda%3BBright%2C+Mary+Anne%3BRutten%2C+Lila+J.+Finney%3BAtienza%2C+Audie+A%3BTreiman%2C+Katherine%3BMoser%2C+Richard+P%3BHesse%2C+Bradford&rft.aulast=Squiers&rft.aufirst=Linda&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730600637517 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 6520; 5790 5772; 10449 5772; 5792 10484 DO - http://dx.doi.org/10.1080/10810730600637517 ER - TY - JOUR T1 - The health information national trends survey (HINTS): research from the baseline AN - 36458745; 3343918 JF - Journal of health communication AU - Ratzan, Scott C AU - Croyle, Robert T AU - Hesse, Bradford W AU - Moser, Richard P AU - Rutten, Lila J. Finney AU - Kreps, Gary L AU - Viswanath, K AU - Breen, Nancy AU - Meissner, Helen AU - Steele, Whitney Randolph AU - Rakowski, William AU - Ford, Jennifer S AU - Coups, Elliot J AU - Hay, Jennifer L AU - Zajac, Laura E AU - Klein, William M.P. AU - McCaul, Kevin D AU - Han, Paul K.J. AU - Coups, Elliot AU - Dillard, Amanda J AU - Cerully, Jennifer L AU - Squiers, Linda AU - Bright, Mary Anne AU - Atienza, Audie A AU - Treiman, Katherine AU - Augustson, Erik AU - Wanke, Kay AU - Shim, Minsun AU - Kelly, Bridget AU - Hornik, Robert AU - Nguyen, Giang T AU - Bellamy, Scarlett L AU - Ling, Bruce S AU - Dang, Qianyu AD - National Cancer Institute ; George Mason University ; Harvard University ; Brown University ; Memorial Sloan-Kettering Cancer Center ; University of Pittsburgh ; North Dakota State University ; National Cancer Institute-Frederick ; National Cancer Institute, Bethesda ; University of Pennsylvania Y1 - 2006 PY - 2006 DA - 2006 SP - vii EP - 190 VL - 11 IS - Supp.1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Comparative analysis KW - Communication KW - Surveys KW - Patients KW - Cancer KW - Knowledge KW - Access to information KW - Public health KW - Smoking KW - Risk KW - Health care KW - Racial inequality KW - Diet KW - Information dissemination KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36458745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=The+health+information+national+trends+survey+%28HINTS%29%3A+research+from+the+baseline&rft.au=Ratzan%2C+Scott+C%3BCroyle%2C+Robert+T%3BHesse%2C+Bradford+W%3BMoser%2C+Richard+P%3BRutten%2C+Lila+J.+Finney%3BKreps%2C+Gary+L%3BViswanath%2C+K%3BBreen%2C+Nancy%3BMeissner%2C+Helen%3BSteele%2C+Whitney+Randolph%3BRakowski%2C+William%3BFord%2C+Jennifer+S%3BCoups%2C+Elliot+J%3BHay%2C+Jennifer+L%3BZajac%2C+Laura+E%3BKlein%2C+William+M.P.%3BMcCaul%2C+Kevin+D%3BHan%2C+Paul+K.J.%3BCoups%2C+Elliot%3BDillard%2C+Amanda+J%3BCerully%2C+Jennifer+L%3BSquiers%2C+Linda%3BBright%2C+Mary+Anne%3BAtienza%2C+Audie+A%3BTreiman%2C+Katherine%3BAugustson%2C+Erik%3BWanke%2C+Kay%3BShim%2C+Minsun%3BKelly%2C+Bridget%3BHornik%2C+Robert%3BNguyen%2C+Giang+T%3BBellamy%2C+Scarlett+L%3BLing%2C+Bruce+S%3BDang%2C+Qianyu&rft.aulast=Ratzan&rft.aufirst=Scott&rft.date=2006-01-01&rft.volume=11&rft.issue=Supp.1&rft.spage=vii&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 14 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 518 6515; 10568 6489; 7073; 1939 3617 6220; 11035; 2630 971; 11755 5707 6071 1542 11325; 3545 8808; 9271 7890 5792 10484; 5775 13521; 2572; 6520; 5790 5772; 10449 5772; 12429 ER - TY - JOUR T1 - Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses AN - 21347406; 7671426 AB - Background High-throughput genotyping generates vast amounts of data for analysis; results can be difficult to summarize succinctly. A single project may involve genotyping many genes with multiple variants per gene and analyzing each variant in relation to numerous phenotypes, using several genetic models and population subgroups. Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association. Results To facilitate visual display and summary of large numbers of association tests of genetic loci with multiple phenotypes, we developed a Phenotype-Genotype Association (PGA) grid display. A database-backed web server was used to create PGA grids from phenotypic and genotypic data (sample sizes, means and standard errors, P-value for association). HTML pages were generated using Tcl scripts on an AOLserver platform, using an Oracle database, and the ArsDigita Community System web toolkit. The grids are interactive and permit display of summary data for individual cells by a mouse click (i.e. least squares means for a given SNP and phenotype, specified genetic model and study sample). PGA grids can be used to visually summarize results of individual SNP associations, gene-environment associations, or haplotype associations. Conclusion The PGA grid, which permits interactive exploration of large numbers of association test results, can serve as an easily adapted common and useful display format for large-scale genetic studies. Doing so would reduce the problem of publication bias, and would simplify the task of summarizing large-scale association studies. JF - BMC Genetics AU - Levy, Daniel AU - DePalma, Steven R AU - Benjamin, Emelia J AU - O'Donnell, Christopher J AU - Parise, Helen AU - Hirschhorn, Joel N AU - Vasan, Ramachandran S AU - Izumo, Seigo AU - Larson, Martin G AD - 1 From the National Heart, Lung, and Blood Institute, Bethesda, MD, USA, levyd@nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 30 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Population genetics KW - Databases KW - Association analysis KW - Data processing KW - Haplotypes KW - Single-nucleotide polymorphism KW - Genotyping KW - Statistical analysis KW - Internet KW - Period protein KW - G 07870:Mammals KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21347406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genetics&rft.atitle=Phenotype-genotype+association+grid%3A+a+convenient+method+for+summarizing+multiple+association+analyses&rft.au=Levy%2C+Daniel%3BDePalma%2C+Steven+R%3BBenjamin%2C+Emelia+J%3BO%27Donnell%2C+Christopher+J%3BParise%2C+Helen%3BHirschhorn%2C+Joel+N%3BVasan%2C+Ramachandran+S%3BIzumo%2C+Seigo%3BLarson%2C+Martin+G&rft.aulast=Levy&rft.aufirst=Daniel&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=BMC+Genetics&rft.issn=1471-2156&rft_id=info:doi/10.1186%2F1471-2156-7-30 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Databases; Population genetics; Association analysis; Data processing; Haplotypes; Single-nucleotide polymorphism; Genotyping; Statistical analysis; Internet; Period protein DO - http://dx.doi.org/10.1186/1471-2156-7-30 ER - TY - JOUR T1 - A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q AN - 21345263; 7671427 AB - Background Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs in African American subjects using a sliding window approach. While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals. Results We present a newly developed tool, Graphical Assessment of Sliding P-values or GrASP, which uses color display to indicate the width of the sliding windows, significance of individual tests, density of SNP coverage and location of known genes that simplifies some of these issues, and use it to identify regions of interest in these data. Conclusion We demonstrate that GrASP makes it easier to visualize, summarize and prioritize regions of interest from sliding window haplotype analysis, based jointly on the p-value from all the tests from these windows and the building of haplotypes of significance in the region. Using this approach, five regions yielded strong evidence for linkage and association with asthma, including the prior peak linkage region. JF - BMC Genetics AU - Mathias, Rasika A AU - Gao, Peisong AU - Goldstein, Janet L AU - Wilson, Alexander F AU - Pugh, Elizabeth W AU - Furbert-Harris, Paulette AU - Dunston, Georgia M AU - Malveaux, Floyd J AU - Togias, Alkis AU - Barnes, Kathleen C AU - Beaty, Terri H AU - Huang, Shau-Ku AD - 1 Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA, rmathias1@mail.nih.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 38 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - chromosome 11 KW - Data processing KW - Haplotypes KW - Single-nucleotide polymorphism KW - Genotyping KW - Asthma KW - Color KW - G 07880:Human Genetics KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genetics&rft.atitle=A+graphical+assessment+of+p-values+from+sliding+window+haplotype+tests+of+association+to+identify+asthma+susceptibility+loci+on+chromosome+11q&rft.au=Mathias%2C+Rasika+A%3BGao%2C+Peisong%3BGoldstein%2C+Janet+L%3BWilson%2C+Alexander+F%3BPugh%2C+Elizabeth+W%3BFurbert-Harris%2C+Paulette%3BDunston%2C+Georgia+M%3BMalveaux%2C+Floyd+J%3BTogias%2C+Alkis%3BBarnes%2C+Kathleen+C%3BBeaty%2C+Terri+H%3BHuang%2C+Shau-Ku&rft.aulast=Mathias&rft.aufirst=Rasika&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=BMC+Genetics&rft.issn=1471-2156&rft_id=info:doi/10.1186%2F1471-2156-7-38 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - chromosome 11; Data processing; Haplotypes; Single-nucleotide polymorphism; Genotyping; Asthma; Color DO - http://dx.doi.org/10.1186/1471-2156-7-38 ER - TY - JOUR T1 - Production of human I- sub(1 )proteinase inhibitor from Aspergillus niger AN - 21327697; 11704315 JF - Microbial Cell Factories AU - Chill, Liat AU - Trinh, Loc B AU - Karnaukhova, Elena AU - Ophir, Yakir AU - Golding, Basil AU - Shiloach, Joseph AD - Biotechnology Unit, NIDDK, NIH, Bethesda, MD 28092, USA Y1 - 2006 PY - 2006 DA - 2006 SP - P62 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - Suppl 1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Proteinase inhibitors KW - Aspergillus niger KW - A 01490:Miscellaneous KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21327697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Cell+Factories&rft.atitle=Production+of+human+I-+sub%281+%29proteinase+inhibitor+from+Aspergillus+niger&rft.au=Chill%2C+Liat%3BTrinh%2C+Loc+B%3BKarnaukhova%2C+Elena%3BOphir%2C+Yakir%3BGolding%2C+Basil%3BShiloach%2C+Joseph&rft.aulast=Chill&rft.aufirst=Liat&rft.date=2006-01-01&rft.volume=5&rft.issue=Suppl+1&rft.spage=P62&rft.isbn=&rft.btitle=&rft.title=Microbial+Cell+Factories&rft.issn=1475-2859&rft_id=info:doi/10.1186%2F1475-2859-5-S1-P62 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Proteinase inhibitors; Aspergillus niger DO - http://dx.doi.org/10.1186/1475-2859-5-S1-P62 ER - TY - JOUR T1 - Stemming cartilage degeneration: Adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering AN - 21304246; 7092873 JF - Arthritis & Rheumatism AU - Tuan, Rocky S AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, tuanr@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3075 EP - 3078 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 10 SN - 0004-3591, 0004-3591 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Degeneration KW - Cartilage (articular) KW - Tissue engineering KW - Mesenchyme KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21304246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+%26+Rheumatism&rft.atitle=Stemming+cartilage+degeneration%3A+Adult+mesenchymal+stem+cells+as+a+cell+source+for+articular+cartilage+tissue+engineering&rft.au=Tuan%2C+Rocky+S&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2006-01-01&rft.volume=54&rft.issue=10&rft.spage=3075&rft.isbn=&rft.btitle=&rft.title=Arthritis+%26+Rheumatism&rft.issn=00043591&rft_id=info:doi/10.1002%2Fart.22148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Stem cells; Degeneration; Mesenchyme; Tissue engineering; Cartilage (articular) DO - http://dx.doi.org/10.1002/art.22148 ER - TY - JOUR T1 - Increasing Parent Limits on Novice Young Drivers. Cognitive Mediation of the Effect of Persuasive Messages AN - 21303424; 11614055 AB - This report describes intervention effects on parent-imposed driving limits on novice young drivers at licensure. Parent-adolescent dyads (4,344) completed baseline surveys at permit and were randomly assigned to intervention or comparison groups. Intervention families received persuasive communications related to protection motivation theory variables including threat appraisal regarding high-risk adolescent driving and coping appraisal regarding restrictions on high-risk driving conditions during the early months of adolescent licensure. Comparison families received standard information on driving, vehicles, and road safety. Among the 4,344 families, 3,786 adolescents obtained licenses, and 3,398 parent-adolescent dyads completed surveys at licensure. Significant treatment group differences favoring the Checkpoints Program were found at licensure for driving limits, perceived risk, expected limits, and outcome expectations. Perceived risk and outcome expectations partially mediated and expected limits fully mediated treatment effects. The results provide evidence that persuasive materials can alter threat and coping appraisal and expectations, thereby increasing parent-imposed driving limits at licensure. JF - Journal of Adolescent Research AU - Simons-Morton, Bruce G AU - Hartos, Jessica L AU - Leaf, William A AU - Preusser, David F AD - National Institute of Child Health and Human Development, Bethesda, MD Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 83 EP - 105 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 21 IS - 1 SN - 0743-5584, 0743-5584 KW - Risk Abstracts KW - Communications KW - Perception KW - intervention KW - Adolescents KW - traffic safety KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21303424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Research&rft.atitle=Increasing+Parent+Limits+on+Novice+Young+Drivers.+Cognitive+Mediation+of+the+Effect+of+Persuasive+Messages&rft.au=Simons-Morton%2C+Bruce+G%3BHartos%2C+Jessica+L%3BLeaf%2C+William+A%3BPreusser%2C+David+F&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Research&rft.issn=07435584&rft_id=info:doi/10.1177%2F0743558405282282 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Communications; Perception; intervention; traffic safety; Adolescents DO - http://dx.doi.org/10.1177/0743558405282282 ER - TY - JOUR T1 - State of the art: refinement of multiple sequence alignments AN - 21239865; 7670732 AB - Background Accurate multiple sequence alignments of proteins are very important in computational biology today. Despite the numerous efforts made in this field, all alignment strategies have certain shortcomings resulting in alignments that are not always correct. Refinement of existing alignment can prove to be an intelligent choice considering the increasing importance of high quality alignments in large scale high-throughput analysis. Results We provide an extensive comparison of the performance of the alignment refinement algorithms. The accuracy and efficiency of the refinement programs are compared using the 3D structure-based alignments in the BAliBASE benchmark database as well as manually curated high quality alignments from Conserved Domain Database (CDD). Conclusion Comparison of performance for refined alignments revealed that despite the absence of dramatic improvements, our refinement method, REFINER, which uses conserved regions as constraints performs better in improving the alignments generated by different alignment algorithms. In most cases REFINER produces a higher-scoring, modestly improved alignment that does not deteriorate the well-conserved regions of the original alignment. JF - BMC Bioinformatics AU - Chakrabarti, Saikat AU - Lanczycki, Christopher J AU - Panchenko, Anna R AU - Przytycka, Teresa M AU - Thiessen, Paul A AU - Bryant, Stephen H AD - 1 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, chakraba@ncbi.nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 499 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Databases KW - Nucleotide sequence KW - Algorithms KW - Bioinformatics KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21239865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=State+of+the+art%3A+refinement+of+multiple+sequence+alignments&rft.au=Chakrabarti%2C+Saikat%3BLanczycki%2C+Christopher+J%3BPanchenko%2C+Anna+R%3BPrzytycka%2C+Teresa+M%3BThiessen%2C+Paul+A%3BBryant%2C+Stephen+H&rft.aulast=Chakrabarti&rft.aufirst=Saikat&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-7-499 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Algorithms; Databases; Nucleotide sequence; Computer programs; Bioinformatics; Computer applications DO - http://dx.doi.org/10.1186/1471-2105-7-499 ER - TY - JOUR T1 - New directions in biomedical text annotation: definitions, guidelines and corpus construction AN - 21239008; 7670653 AB - Background While biomedical text mining is emerging as an important research area, practical results have proven difficult to achieve. We believe that an important first step towards more accurate text-mining lies in the ability to identify and characterize text that satisfies various types of information needs. We report here the results of our inquiry into properties of scientific text that have sufficient generality to transcend the confines of a narrow subject area, while supporting practical mining of text for factual information. Our ultimate goal is to annotate a significant corpus of biomedical text and train machine learning methods to automatically categorize such text along certain dimensions that we have defined. Results We have identified five qualitative dimensions that we believe characterize a broad range of scientific sentences, and are therefore useful for supporting a general approach to text-mining: focus, polarity, certainty, evidence, and directionality. We define these dimensions and describe the guidelines we have developed for annotating text with regard to them. To examine the effectiveness of the guidelines, twelve annotators independently annotated the same set of 101 sentences that were randomly selected from current biomedical periodicals. Analysis of these annotations shows 70-80% inter-annotator agreement, suggesting that our guidelines indeed present a well-defined, executable and reproducible task. Conclusion We present our guidelines defining a text annotation task, along with annotation results from multiple independently produced annotations, demonstrating the feasibility of the task. The annotation of a very large corpus of documents along these guidelines is currently ongoing. These annotations form the basis for the categorization of text along multiple dimensions, to support viable text mining for experimental results, methodology statements, and other forms of information. We are currently developing machine learning methods, to be trained and tested on the annotated corpus, that would allow for the automatic categorization of biomedical text along the general dimensions that we have presented. The guidelines in full detail, along with annotated examples, are publicly available. JF - BMC Bioinformatics AU - Wilbur, W John AU - Rzhetsky, Andrey AU - Shatkay, Hagit AD - 1 National Center for Biotechnology Information NLM, NIH, Bethesda, MD, USA, wilbur@ncbi.nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 356 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Polarity KW - Language KW - Bioinformatics KW - Learning algorithms KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21239008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=New+directions+in+biomedical+text+annotation%3A+definitions%2C+guidelines+and+corpus+construction&rft.au=Wilbur%2C+W+John%3BRzhetsky%2C+Andrey%3BShatkay%2C+Hagit&rft.aulast=Wilbur&rft.aufirst=W&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-7-356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Language; Learning algorithms; Polarity; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-7-356 ER - TY - JOUR T1 - Identifying genes that contribute most to good classification in microarrays AN - 21236071; 7670665 AB - Background The goal of most microarray studies is either the identification of genes that are most differentially expressed or the creation of a good classification rule. The disadvantage of the former is that it ignores the importance of gene interactions; the disadvantage of the latter is that it often does not provide a sufficient focus for further investigation because many genes may be included by chance. Our strategy is to search for classification rules that perform well with few genes and, if they are found, identify genes that occur relatively frequently under multiple random validation (random splits into training and test samples). Results We analyzed data from four published studies related to cancer. For classification we used a filter with a nearest centroid rule that is easy to implement and has been previously shown to perform well. To comprehensively measure classification performance we used receiver operating characteristic curves. In the three data sets with good classification performance, the classification rules for 5 genes were only slightly worse than for 20 or 50 genes and somewhat better than for 1 gene. In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia. Conclusion Using multiple random validation, investigators should look for classification rules that perform well with few genes and select, for further study, genes with relatively high frequencies of occurrence in these classification rules. JF - BMC Bioinformatics AU - Baker, Stuart G AU - Kramer, Barnett S AD - 1 Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7354, USA, sb16i@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 407 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Proteoglycans KW - Leukemia KW - Data processing KW - Classification KW - Secretory vesicles KW - Colon cancer KW - Bioinformatics KW - DNA microarrays KW - Desmin KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21236071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Identifying+genes+that+contribute+most+to+good+classification+in+microarrays&rft.au=Baker%2C+Stuart+G%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-7-407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; DNA microarrays; Bioinformatics; Proteoglycans; Classification; Desmin; Secretory vesicles; Leukemia; Filters; Colon cancer DO - http://dx.doi.org/10.1186/1471-2105-7-407 ER - TY - JOUR T1 - ROC and confusion analysis of structure comparison methods identify the main causes of divergence from manual protein classification AN - 21235980; 7670589 AB - Background Current classification of protein folds are based, ultimately, on visual inspection of similarities. Previous attempts to use computerized structure comparison methods show only partial agreement with curated databases, but have failed to provide detailed statistical and structural analysis of the causes of these divergences. Results We construct a map of similarities/dissimilarities among manually defined protein folds, using a score cutoff value determined by means of the Receiver Operating Characteristics curve. It identifies folds which appear to overlap or to be "confused" with each other by two distinct similarity measures. It also identifies folds which appear inhomogeneous in that they contain apparently dissimilar domains, as measured by both similarity measures. At a low (1%) false positive rate, 25 to 38% of domain pairs in the same SCOP folds do not appear similar. Our results suggest either that some of these folds are defined using criteria other than purely structural consideration or that the similarity measures used do not recognize some relevant aspects of structural similarity in certain cases. Specifically, variations of the "common core" of some folds are severe enough to defeat attempts to automatically detect structural similarity and/or to lead to false detection of similarity between domains in distinct folds. Structures in some folds vary greatly in size because they contain varying numbers of a repeating unit, while similarity scores are quite sensitive to size differences. Structures in different folds may contain similar substructures, which produce false positives. Finally, the common core within a structure may be too small relative to the entire structure, to be recognized as the basis of similarity to another. Conclusion A detailed analysis of the entire available protein fold space by two automated similarity methods reveals the extent and the nature of the divergence between the automatically determined similarity/dissimilarity and the manual fold type classifications. Some of the observed divergences can probably be addressed with better structure comparison methods and better automatic, intelligent classification procedures. Others may be intrinsic to the problem, suggesting a continuous rather than discrete protein fold space. JF - BMC Bioinformatics AU - Sam, Vichetra AU - Tai, Chin-Hsien AU - Garnier, Jean AU - Gibrat, Jean-Francois AU - Lee, Byungkook AU - Munson, Peter J AD - 1 Mathematical and Statistical Computing Laboratory, DCB, CIT, NIH, DHHS, Bethesda, MD, USA, vsam@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 206 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Statistics KW - Protein folding KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21235980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=ROC+and+confusion+analysis+of+structure+comparison+methods+identify+the+main+causes+of+divergence+from+manual+protein+classification&rft.au=Sam%2C+Vichetra%3BTai%2C+Chin-Hsien%3BGarnier%2C+Jean%3BGibrat%2C+Jean-Francois%3BLee%2C+Byungkook%3BMunson%2C+Peter+J&rft.aulast=Sam&rft.aufirst=Vichetra&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-7-206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Protein folding; Statistics; Databases; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-7-206 ER - TY - JOUR T1 - Computational models with thermodynamic and composition features improve siRNA design AN - 21235772; 7670501 AB - Background Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large functional genomics projects. Results To improve the design of efficient siRNA molecules, we performed a comparative, thermodynamic and correlation analysis on a heterogeneous set of 653 siRNAs collected from the literature. We used this training set to select siRNA features and optimize computational models. We identified 18 parameters that correlate significantly with silencing efficiency. Some of these parameters characterize only the siRNA sequence, while others involve the whole mRNA. Most importantly, we derived an siRNA position-dependent consensus, and optimized the free-energy difference of the 5' and 3' terminal dinucleotides of the siRNA antisense strand. The position-dependent consensus is based on correlation and t-test analyses of the training set, and accounts for both significantly preferred and avoided nucleotides in all sequence positions. On the training set, the two parameters' correlation with silencing efficiency was 0.5 and 0.36, respectively. Among other features, a dinucleotide content index and the frequency of potential targets for siRNA in the mRNA added predictive power to our model (R = 0.55). We showed that our model is effective for predicting the efficiency of siRNAs at different concentrations. We optimized a neural network model on our training set using three parameters characterizing the siRNA sequence, and predicted efficiencies for the test siRNA dataset recently published by Novartis. On this validation set, the correlation coefficient between predicted and observed efficiency was 0.75. Using the same model, we performed a transcriptome-wide analysis of optimal siRNA targets for 22,600 human mRNAs. Conclusion We demonstrated that the properties of the siRNAs themselves are essential for efficient RNA interference. The 5' ends of antisense strands of efficient siRNAs are U-rich and possess a content similarity to the pyrimidine-rich oligonucleotides interacting with the polypurine RNA tracks that are recognized by RNase H. The advantage of our method over similar methods is the small number of parameters. As a result, our method requires a much smaller training set to produce consistent results. Other mRNA features, though expensive to compute, can slightly improve our model. JF - BMC Bioinformatics AU - Shabalina, Svetlana A AU - Spiridonov, Alexey N AU - Ogurtsov, Aleksey Y AD - 1 National Center for Biotechnology Information, National Library of Medicine, National Institute of Health, Bethesda, MD 20894, USA, shabalin@ncbi.nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 65 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Thermodynamics KW - Neural networks KW - Nucleotide sequence KW - Correlation analysis KW - Oligonucleotides KW - Free energy KW - Models KW - Antisense KW - siRNA KW - Ribonuclease H KW - Conserved sequence KW - RNA-mediated interference KW - genomics KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21235772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Computational+models+with+thermodynamic+and+composition+features+improve+siRNA+design&rft.au=Shabalina%2C+Svetlana+A%3BSpiridonov%2C+Alexey+N%3BOgurtsov%2C+Aleksey+Y&rft.aulast=Shabalina&rft.aufirst=Svetlana&rft.date=2006-01-01&rft.volume=7&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-7-65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - siRNA; Antisense; Mathematical models; Thermodynamics; Neural networks; Oligonucleotides; Bioinformatics; Free energy; Ribonuclease H; genomics; Models; Nucleotide sequence; RNA-mediated interference; Correlation analysis; Conserved sequence DO - http://dx.doi.org/10.1186/1471-2105-7-65 ER - TY - JOUR T1 - The crossroads of GIS and health information: a workshop on developing a research agenda to improve cancer control AN - 21220493; 7249743 AB - Cancer control researchers seek to reduce the burden of cancer by studying interventions, their impact in defined populations, and the means by which they can be better used. The first step in cancer control is identifying where the cancer burden is elevated, which suggests locations where interventions are needed. Geographic information systems (GIS) and other spatial analytic methods provide such a solution and thus can play a major role in cancer control. This report presents findings from a workshop held June 16-17, 2005, to bring together experts and stakeholders to address current issues in GIScience and cancer control. A broad range of areas of expertise and interest was represented, including epidemiology, geography, statistics, environmental health, social science, cancer control, cancer registry operations, and cancer advocacy. The goals of this workshop were to build consensus on important policy and research questions, identify roadblocks to future progress in this field, and provide recommendations to overcome these roadblocks. JF - International Journal of Health Geographics AU - Pickle, Linda Williams AU - Szczur, Martha AU - Lewis, Denise Riedel AU - Stinchcomb, David G AD - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD USA, picklel@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 5 SN - 1476-072X, 1476-072X KW - Health & Safety Science Abstracts KW - Article No. 51 KW - intervention KW - Remote sensing KW - Environmental health KW - social sciences KW - Geographic information systems KW - Geography KW - stakeholders KW - Cancer KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Health+Geographics&rft.atitle=The+crossroads+of+GIS+and+health+information%3A+a+workshop+on+developing+a+research+agenda+to+improve+cancer+control&rft.au=Pickle%2C+Linda+Williams%3BSzczur%2C+Martha%3BLewis%2C+Denise+Riedel%3BStinchcomb%2C+David+G&rft.aulast=Pickle&rft.aufirst=Linda&rft.date=2006-01-01&rft.volume=5&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Health+Geographics&rft.issn=1476072X&rft_id=info:doi/10.1186%2F1476-072X-5-51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - intervention; Remote sensing; Environmental health; social sciences; Geographic information systems; Geography; stakeholders; Cancer DO - http://dx.doi.org/10.1186/1476-072X-5-51 ER - TY - JOUR T1 - Monoclonal antibody therapy AN - 21168097; 11197595 AB - The concept of targeted therapy was conceived through increased understanding of the biological pathways involved in the pathogenesis of cancer and subsequently identification of the most appropriate antigens to target. Monoclonal antibody therapy harnesses host defense mechanisms through activation of the antibody dependent cytotoxic pathway and complement mediated cytotoxicity. However, these two processes alone do not explain the therapeutic efficacy of antibody therapy; they also act by apoptotic signaling and growth inhibitory pathways. Conjugation of monoclonal antibody therapy, with radionuclides or toxins, offers more therapeutic approaches. Initial data demonstrates efficacy of single agent use, although combination therapy appears potentially more beneficial. Monoclonal antibody therapy is having a significant impact on many disease processes, particularly malignancies of solid and hematological origin. In this article, we shall review and discuss the monoclonal antibodies approved by the US Food and Drug Administration (FDA), in the management of cancer. JF - Frontiers in Bioscience AU - O'Mahony, D AU - Bishop, M R AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 1620 EP - 1635 VL - 11 SN - 1093-9946, 1093-9946 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Apoptosis KW - Immunotherapy KW - Malignancy KW - Data processing KW - Monoclonal antibodies KW - Toxins KW - Cancer KW - Antibodies KW - Cytotoxicity KW - Reviews KW - Complement activation KW - Radioisotopes KW - Defense mechanisms KW - Signal transduction KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21168097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=Monoclonal+antibody+therapy&rft.au=O%27Mahony%2C+D%3BBishop%2C+M+R&rft.aulast=O%27Mahony&rft.aufirst=D&rft.date=2006-01-01&rft.volume=11&rft.issue=&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Cancer; Cytotoxicity; Malignancy; Immunotherapy; Data processing; Reviews; Toxins; Signal transduction; Antibodies; Defense mechanisms; Complement activation; Radioisotopes; Apoptosis ER - TY - JOUR T1 - Immunotoxins for targeted cancer therapy AN - 21167777; 11177688 AB - Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting protein synthesis. For the immunotoxin to work, it must bind to and be internalized by the target cells, and the enzymatic fragment of the toxin must translocate to the cytosol. Once in the cytosol, 1 molecule is capable of killing a cell, making immunotoxins some of the most potent killing agents. Various plant and bacterial toxins have been genetically fused or chemically conjugated to ligands that bind to cancer cells. Among the most active clinically are those that bind to hematologic tumors. At present, only 1 agent, which contains human interleukin-2 and truncated diphtheria toxin, is approved for use in cutaneous T-cell lymphoma. Another, containing an anti-CD22 Fv and truncatedPseudomonas exotoxin, has induced complete remissions in a high proportion of cases of hairy-cell leukemia. Refinement of existing immunotoxins and development of new immunotoxins are underway to improve the treatment of cancer. JF - AAPS Journal AU - Kreitman, Robert J AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Centers for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124B, 20892-4255 Bethesda, MD, kreitmar@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - E532 EP - E551 PB - American Association of Pharmaceutical Scientists VL - 8 IS - 3 SN - 1550-7416, 1550-7416 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Protein biosynthesis KW - Interleukin 2 KW - Remission KW - Tumors KW - Exotoxins KW - Fv KW - Diphtheria toxin KW - Cancer KW - Toxins KW - Immunotoxins KW - Leukemia KW - Antibodies KW - double prime T-cell lymphoma KW - Cytosol KW - Growth factors KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21167777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Immunotoxins+for+targeted+cancer+therapy&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=8&rft.issue=3&rft.spage=E532&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Faapsj080363 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein biosynthesis; Interleukin 2; Remission; Tumors; Immunotoxins; Toxins; Cancer; Diphtheria toxin; Fv; Exotoxins; Leukemia; Antibodies; double prime T-cell lymphoma; Cytosol; Growth factors DO - http://dx.doi.org/10.1208/aapsj080363 ER - TY - JOUR T1 - Report of the National Heart, Lung, and Blood Institute Working Group on Research in Adult Congenital Heart Disease AN - 21120059; 6820238 AB - The Working Group on research in adult congenital heart disease (ACHD) was convened in September 2004 under the sponsorship of National Heart, Lung, and Blood Institute (NHLBI) and the Office of Rare Diseases, National Institutes of Health, Department of Health and Human Services, to make recommendations on research needs. The purpose of the Working Group was to advise the NHLBI on the current state of the science in ACHD and barriers to optimal clinical care, and to make specific recommendations for overcoming those barriers. The members of the Working Group were chosen to provide expert input on a broad range of research issues from both scientific and lay perspectives. The Working Group reviewed data on the epidemiology of ACHD, long-term outcomes of complex cardiovascular malformations, issues in assessing morphology and function with current imaging techniques, surgical and catheter-based interventions, management of related conditions including pregnancy and arrhythmias, quality of life, and informatics. After research and training barriers were discussed, the Working Group recommended outreach and educational programs for adults with congenital heart disease, a network of specialized adult congenital heart disease regional centers, technology development to support advances in imaging and modeling of abnormal structure and function, and a consensus on appropriate training for physicians to provide care for adults with congenital heart disease. Report of the National Heart, Lung, and Blood Institute Working Group on Research in Adult Congenital Heart Disease Roberta G. Williams, Gail D. Pearson, Robyn J. Barst, John S. Child, Pedro del Nido, Welton M. Gersony, Karen S. Kuehl, Michael J. Landzberg, Merle Myerson, Steven R. Neish, David J. Sahn, Amy Verstappen, Carole A. Warnes, Catherine L. Webb The Working Group on research in adult congenital heart disease was convened in September 2004 under the sponsorship of National Heart, Lung, and Blood Institute and the Office of Rare Diseases, National Institutes of Health, Department of Health and Human Services, to make recommendations on research needs. The Working Group recommended outreach programs, a network of specialized adult congenital heart disease regional centers, technology development to support advances in imaging and modeling, and a consensus on appropriate training for physicians to provide care for adults with congenital heart disease. JF - Journal of the American College of Cardiology AU - Williams, Roberta G AU - Pearson, Gail D AU - Barst, Robyn J AU - Child, John S AU - Nido, Pedro del AU - Gersony, Welton M AU - Kuehl, Karen S AU - Landzberg, Michael J AU - Myerson, Merle AU - Neish, Steven R AU - Sahn, David J AU - Warnes, Carole A AU - Webb, Catherine L AD - Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, pearsong@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 701 EP - 707 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 47 IS - 4 SN - 0735-1097, 0735-1097 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Blood KW - Arrhythmia KW - Data processing KW - Epidemiology KW - Structure-function relationships KW - Informatics KW - Reviews KW - imaging KW - Heart diseases KW - Quality of life KW - Pregnancy KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21120059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Report+of+the+National+Heart%2C+Lung%2C+and+Blood+Institute+Working+Group+on+Research+in+Adult+Congenital+Heart+Disease&rft.au=Williams%2C+Roberta+G%3BPearson%2C+Gail+D%3BBarst%2C+Robyn+J%3BChild%2C+John+S%3BNido%2C+Pedro+del%3BGersony%2C+Welton+M%3BKuehl%2C+Karen+S%3BLandzberg%2C+Michael+J%3BMyerson%2C+Merle%3BNeish%2C+Steven+R%3BSahn%2C+David+J%3BWarnes%2C+Carole+A%3BWebb%2C+Catherine+L&rft.aulast=Williams&rft.aufirst=Roberta&rft.date=2006-01-01&rft.volume=47&rft.issue=4&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2005.08.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood; Arrhythmia; Data processing; Epidemiology; Informatics; Structure-function relationships; Reviews; imaging; Pregnancy; Quality of life; Heart diseases DO - http://dx.doi.org/10.1016/j.jacc.2005.08.074 ER - TY - JOUR T1 - MiniReview: Consequences of Long-Term Proton Pump Blockade: Insights from Studies of Patients with Gastrinomas AN - 21050311; 6637902 AB - Proton pump inhibitors are being increasingly used and for longer periods of time, especially in patients with gastroesophageal reflux disease. Each of these trends has led to numerous studies and reviews of the potential risk-benefit ratio of the long-term use of proton pump inhibitors. Both long-term effects of hypergastrinaemia due to the profound acid suppression caused by proton pump inhibitors as well as the effects of hypo--achlorhydria per se have been raised and studied. Potential areas of concern that have been raised in the long-term use of proton pump inhibitors, which could alter this risk-benefit ratio include: gastric carcinoid formation; the development of rebound acid hypersecretion when proton pump inhibitor treatment is stopped; the development of tolerance; increased oxyntic gastritis in H. pylori patients and the possibility of increasing the risk of gastric cancer; the possible stimulation of growth of non-gastric tumours due to hypergastrinaemia; and the possible effect of the hypo-achlorhydria on nutrient absorption, particularly iron and vitamin B12. Because few patients with idiopathic gastro-oesophageal reflux disease-peptic ulcer disease have been treated long-term (i.e., >10 years), there is little known to address the above areas of potential concern. Most patients with gastrinomas with Zollinger-Ellison syndrome have life-long hypergastrinaemia, require continuous proton pump inhibitors treatment and a number of studies report results of >5-10 years of tratment and follow-up. Therefore, an analysis of Zollinger-Ellison syndrome patients can provide important insights into some of the safety concerns raised above. In this paper, results from studies of Zollinger-Ellison syndrome patients and other recent studies dealing with the safety concerns above, are briefly reviewed. JF - Basic & Clinical Pharmacology & Toxicology AU - Jensen, Robert T AD - Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1804, U.S.A, robertj@bdg10.niddk.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 4 EP - 19 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 98 IS - 1 SN - 1742-7835, 1742-7835 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Protons KW - Nutrients KW - Tumors KW - Long-term effects KW - Gastroesophageal reflux KW - Vitamin B12 KW - Ulcers KW - Reviews KW - Gastric cancer KW - Iron KW - Gastritis KW - X 24360:Metals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21050311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.atitle=MiniReview%3A+Consequences+of+Long-Term+Proton+Pump+Blockade%3A+Insights+from+Studies+of+Patients+with+Gastrinomas&rft.au=Jensen%2C+Robert+T&rft.aulast=Jensen&rft.aufirst=Robert&rft.date=2006-01-01&rft.volume=98&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.issn=17427835&rft_id=info:doi/10.1111%2Fj.1742-7843.2006.pto_378.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - SuppNotes - References, 222. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Long-term effects; Gastroesophageal reflux; Vitamin B12; Ulcers; Protons; Reviews; Nutrients; Tumors; Gastric cancer; Gastritis; Iron; Helicobacter pylori DO - http://dx.doi.org/10.1111/j.1742-7843.2006.pto_378.x ER - TY - JOUR T1 - HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses AN - 21044411; 7113191 AB - BACKGROUND: The consequences of mutations in embryonic and fetal cells are serious and contribute to high prenatal sensitivity to mutagenic agents. An understanding of the factors that influence the yield of such mutations is important for management of adverse effects of perinatal exposures. Resistance to 6-thioguanine (6-TG) can be utilized to study mutational events at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus. HGPRT is X-linked and recessive. According to the Lyon hypothesis, male cells have only one X-chromosome and female cells randomly inactivate the second X-chromosome. This leads to the prediction that X-linked genes should be equally sensitive to the mutagenic effects of toxicants in male and female fetuses. METHODS: We tested this supposition by in utero exposure of Syrian hamster fetuses to N- ethyl-N-nitrosourea (ENU) at day 12 of gestation. ENU is a strong carcinogen and mutagen. HGPRT mutations were detected by selection with 6-TG. RESULTS: Surprisingly. the male cells had 4 to 5 times more 6-TG mutants than female cells, in two separate experiments (p<0.001). Ouabain resistance, reflecting a co-dominant autosomal locus, was used as a control, and we found that there was no significant difference between male and female cells (p=0.549). CONCLUSIONS: Possible reasons for the sex difference in mutations include escape of the second X-chromosome from inactivation in some of the female cells, or higher mutability in male cells. In any event, there is a gender difference in vulnerability to mutation of an X-linked gene that has previously not been appreciated, and that may be relevant to toxicological studies of such genes. HGPRT is frequently used to monitor mutagenic events in human fetuses. Birth Defects Research (Part B), 2006. Published 2006 Wiley-Liss, Inc. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Donovan, Paul J AU - Smith, George T AU - Dove, Lee F AU - Klose, John AU - Powell, Douglas A AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Room 205, NCI-Frederick, Frederick, Maryland, donovapa@mail.ncifcrf.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 399 EP - 404 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 77 IS - 5 SN - 1542-9733, 1542-9733 KW - Genetics Abstracts; Toxicology Abstracts KW - HGPRT KW - male fetuses KW - female fetuses KW - N-ethyl-N-nitrosourea KW - Lyon hypothesis KW - X-chromosome inactivation KW - Mutagens KW - Toxicants KW - X chromosome KW - Intrauterine exposure KW - Carcinogens KW - Sex differences KW - Fetuses KW - Perinatal exposure KW - Gestation KW - Ouabain KW - Congenital defects KW - Ethyl nitrosourea KW - Embryos KW - Mutation KW - Toxicity testing KW - Side effects KW - X 24490:Other KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21044411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=HGPRT+mutation+induction+by+N-ethyl-N-nitrosourea+as+measured+by+6-thioguanine+resistance+is+higher+in+male+than+in+female+Syrian+hamster+fetuses&rft.au=Donovan%2C+Paul+J%3BSmith%2C+George+T%3BDove%2C+Lee+F%3BKlose%2C+John%3BPowell%2C+Douglas+A&rft.aulast=Donovan&rft.aufirst=Paul&rft.date=2006-01-01&rft.volume=77&rft.issue=5&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mutagens; Toxicants; X chromosome; Carcinogens; Intrauterine exposure; Sex differences; Fetuses; Perinatal exposure; Gestation; Ethyl nitrosourea; Congenital defects; Ouabain; Embryos; Toxicity testing; Mutation; Side effects DO - http://dx.doi.org/10.1002/bdrb.20088 ER - TY - JOUR T1 - Decomposition of overlapping protein complexes: A graph theoretical method for analyzing static and dynamic protein associations AN - 21035534; 7155130 AB - Background Most cellular processes are carried out by multi-protein complexes, groups of proteins that bind together to perform a specific task. Some proteins form stable complexes, while other proteins form transient associations and are part of several complexes at different stages of a cellular process. A better understanding of this higher-order organization of proteins into overlapping complexes is an important step towards unveiling functional and evolutionary mechanisms behind biological networks. Results We propose a new method for identifying and representing overlapping protein complexes (or larger units called functional groups) within a protein interaction network. We develop a graph-theoretical framework that enables automatic construction of such representation. We illustrate the effectiveness of our method by applying it to TNF alpha /NF- Kappa B and pheromone signaling pathways. Conclusion The proposed representation helps in understanding the transitions between functional groups and allows for tracking a protein's path through a cascade of functional groups. Therefore, depending on the nature of the network, our representation is capable of elucidating temporal relations between functional groups. Our results show that the proposed method opens a new avenue for the analysis of protein interaction networks. JF - Algorithms for Molecular Biology AU - Zotenko, Elena AU - Guimaraes, Katia S AU - Jothi, Raja AU - Przytycka, Teresa M AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1748-7188, 1748-7188 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 7 KW - Pheromones KW - Tumor necrosis factor-^a KW - Algorithms KW - NF-^KB protein KW - Decomposition KW - Evolution KW - Protein interaction KW - Signal transduction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Algorithms+for+Molecular+Biology&rft.atitle=Decomposition+of+overlapping+protein+complexes%3A+A+graph+theoretical+method+for+analyzing+static+and+dynamic+protein+associations&rft.au=Zotenko%2C+Elena%3BGuimaraes%2C+Katia+S%3BJothi%2C+Raja%3BPrzytycka%2C+Teresa+M&rft.aulast=Zotenko&rft.aufirst=Elena&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Algorithms+for+Molecular+Biology&rft.issn=17487188&rft_id=info:doi/10.1186%2F1748-7188-1-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Signal transduction; Algorithms; Tumor necrosis factor-^a; Protein interaction; Pheromones; NF-^KB protein; Evolution; Decomposition DO - http://dx.doi.org/10.1186/1748-7188-1-7 ER - TY - JOUR T1 - NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene super(-) super(¶ ) super(| | ) AN - 21027646; 6838248 JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Luderer, Ulrike AU - Collins, Thomas FX AU - Daston, George P AU - Fischer, Lawrence J AU - Gray, Ronald H AU - Mirer, Franklin E AU - Olshan, Andrew F AU - Setzer, RWoodrow AU - Treinen, Kimberley A AU - Vermeulen, Roel AD - University of California-Irvine, Irvine, CA, shelby@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 110 EP - 193 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 77 IS - 2 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Congenital defects KW - Toxicity KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21027646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=NTP-CERHR+Expert+Panel+Report+on+the+reproductive+and+developmental+toxicity+of+styrene+super%28-%29+super%28%C2%B6+%29+super%28%7C+%7C+%29&rft.au=Luderer%2C+Ulrike%3BCollins%2C+Thomas+FX%3BDaston%2C+George+P%3BFischer%2C+Lawrence+J%3BGray%2C+Ronald+H%3BMirer%2C+Franklin+E%3BOlshan%2C+Andrew+F%3BSetzer%2C+RWoodrow%3BTreinen%2C+Kimberley+A%3BVermeulen%2C+Roel&rft.aulast=Luderer&rft.aufirst=Ulrike&rft.date=2006-01-01&rft.volume=77&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fcbic.200500444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Congenital defects; Toxicity DO - http://dx.doi.org/10.1002/cbic.200500444 ER - TY - JOUR T1 - Assessment of Polyp and Mass Histopathology by Intravenous Contrast- Enhanced CT Colonography AN - 21022233; 8566816 AB - Rationale and Objectives - We sought to demonstrate that intravenous contrast-enhanced CT colonography (CTC) can distinguish colonic adenomas from carcinomas. Methods - Supine intravenous contrast-enhanced CTC with colonoscopic and/or surgical correlation was performed on 25 patients with colonic adenomas or carcinomas. Standard deviation of mean polyp CT attenuation was computed and assessed using ANOVA and receiver-operating characteristic analyses. Results - Colonoscopy confirmed 32 polyps or masses 1 to 8 cm in size. The standard deviations of CT attenuation were carcinomas (n = 13; 36 6 HU; range 28-48 HU) and adenomas (n = 19; 49 14 HU; range 31-100 HU) (P = 0.005). At a standard deviation threshold of 42 HU, the sensitivity and specificity for classifying a polyp or mass as a carcinoma were 92% and 79%, respectively. The area under the receiver- operating characteristic curve was 0.89 0.06 (95% confidence interval 0.73-0.96). Conclusions - Measurement of the standard deviation of CT attenuation on intravenous contrast-enhanced CTC permits histopathologic classification of polyps 1 cm or larger as carcinomas versus adenomas. The presence of ulceration or absence of muscular invasion in carcinomas creates overlap with adenomas, reducing the specificity of carcinoma classification. JF - Academic Radiology AU - Summers, Ronald M AU - Huang, Adam AU - Yao, Jianhua AU - Campbell, Shannon R AU - Dempsey, Jennifer E AU - Dwyer, Andrew J AU - Franaszek, Marek AU - Brickman, Danny S AU - Bitter, Ingmar AU - Petrick, Nicholas AU - Hara, Amy K AD - Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg. 10, Room 1C351, 10 Center 1182, Bethesda, 20892-1182, rms@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1490 EP - 1495 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 13 IS - 12 SN - 1076-6332, 1076-6332 KW - Biotechnology and Bioengineering Abstracts KW - CT, colon KW - CT, 3D reconstruction KW - colon cancer KW - image processing KW - intravenous contrast enhancement KW - Intravenous administration KW - Standard deviation KW - Classification KW - Polyps KW - Adenoma KW - Carcinoma KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+Radiology&rft.atitle=Assessment+of+Polyp+and+Mass+Histopathology+by+Intravenous+Contrast-+Enhanced+CT+Colonography&rft.au=Summers%2C+Ronald+M%3BHuang%2C+Adam%3BYao%2C+Jianhua%3BCampbell%2C+Shannon+R%3BDempsey%2C+Jennifer+E%3BDwyer%2C+Andrew+J%3BFranaszek%2C+Marek%3BBrickman%2C+Danny+S%3BBitter%2C+Ingmar%3BPetrick%2C+Nicholas%3BHara%2C+Amy+K&rft.aulast=Summers&rft.aufirst=Ronald&rft.date=2006-01-01&rft.volume=13&rft.issue=12&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Academic+Radiology&rft.issn=10766332&rft_id=info:doi/10.1016%2Fj.acra.2006.09.051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Standard deviation; Classification; Polyps; Adenoma; Carcinoma DO - http://dx.doi.org/10.1016/j.acra.2006.09.051 ER - TY - JOUR T1 - Role of the luxS Quorum-Sensing System in Biofilm Formation and Virulence of Staphylococcus epidermidis AN - 20985652; 6576939 AB - Nosocomial infections caused by Staphylococcus epidermidis are characterized by biofilm formation on implanted medical devices. Quorum-sensing regulation plays a major role in the biofilm development of many bacterial pathogens. Here, we describe luxS, a quorum-sensing system in staphylococci that has a significant impact on biofilm development and virulence. We constructed an isogenic Delta luxS mutant strain of a biofilm-forming clinical isolate of S. epidermidis and demonstrated that luxS signaling is functional in S. epidermidis. The mutant strain showed increased biofilm formation in vitro and enhanced virulence in a rat model of biofilm-associated infection. Genetic complementation and addition of autoinducer 2-containing culture filtrate restored the wild-type phenotype, demonstrating that luxS repressed biofilm formation through a cell-cell signaling mechanism based on autoinducer 2 secretion. Enhanced production of the biofilm exopolysaccharide polysaccharide intercellular adhesin in the mutant strain is presumably the major cause of the observed phenotype. The agr quorum-sensing system has previously been shown to impact biofilm development and biofilm-associated infection in a way similar to that of luxS, although by regulation of different factors. Our study indicates a general scheme of quorum-sensing regulation of biofilm development in staphylococci, which contrasts with that observed in many other bacterial pathogens. JF - Infection and Immunity AU - Xu, Lin AU - Li, Hualin AU - Vuong, Cuong AU - Vadyvaloo, Viveka AU - Wang, Jianping AU - Yao, Yufeng AU - Otto, Michael AU - Gao, Qian AD - Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China. Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of China. Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Hamilton, Montana 59840 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 488 EP - 496 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - LuxS gene KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Adhesins KW - LuxS protein KW - quorum sensing KW - Animal models KW - Cell culture KW - Development KW - Pathogens KW - Polysaccharides KW - exopolysaccharides KW - Virulence KW - Complementation KW - Nosocomial infection KW - Biofilms KW - Staphylococcus epidermidis KW - N-octanoylhomoserine lactone KW - Signal transduction KW - F 06910:Microorganisms & Parasites KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20985652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Role+of+the+luxS+Quorum-Sensing+System+in+Biofilm+Formation+and+Virulence+of+Staphylococcus+epidermidis&rft.au=Xu%2C+Lin%3BLi%2C+Hualin%3BVuong%2C+Cuong%3BVadyvaloo%2C+Viveka%3BWang%2C+Jianping%3BYao%2C+Yufeng%3BOtto%2C+Michael%3BGao%2C+Qian&rft.aulast=Xu&rft.aufirst=Lin&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Adhesins; LuxS protein; quorum sensing; Animal models; Cell culture; Pathogens; Development; Polysaccharides; exopolysaccharides; Virulence; Complementation; Nosocomial infection; Biofilms; N-octanoylhomoserine lactone; Signal transduction; Staphylococcus epidermidis ER - TY - JOUR T1 - Occupational and environmental associations with antinuclear antibodies in a general population sample AN - 20926315; 7179037 AB - Antinuclear antibodies are a hallmark feature of the autoimmune disease systemic lupus erythematosus, and can occur many years before onset of symptoms. The objective of this study was to examine the association between exposures and high-titer antinuclear antibodies in the general population (i.e., people who do not have lupus or other systemic autoimmune diseases). Serum was collected from 266 population-based controls who had been frequency-matched to the age and gender distribution of lupus cases in a 60-county study area in the southeastern United States. A detailed occupational history was collected using a structured interview; information was also collected on hair dye use. Antinuclear antibodies were assayed using HEp-2 cells as substrate. Logistic regression was used to estimate the odds ratio (OR) as a measure of association between exposures and high-titer antinuclear antibody levels, adjusting for age, gender, and race. High-titer antinuclear antibodies ( greater than or equal to 1:160) were observed in 21 subjects (8%). A twofold increased prevalence of high-titer antinuclear antibodies was seen with some occupational exposures (silica dust, pesticides, and sunlight), although none of these individual estimates were statistically significant. The association seen with use of hair dyes was weaker (OR 1.4). There was a suggestion of a dose response with a combined measure based on the summation of exposures (ORs of 1.7, 2.1, and 5.9 for 1, 2, and greater than or equal to 3 exposures). These data suggest that occupational exposures may influence the expression of antinuclear antibodies. Larger studies addressing these exposures may provide insights into the mechanisms by which various environmental factors affect the development of autoantibodies and the progression to clinical disease. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Cooper, G S AU - Parks, C G AU - Schur, P S AU - Fraser, P A AD - Epidemiology Branch MD A3-05, NIEHS, PO Box 12233, Durham, NC 27709, USA, gscooper1@gmail.com Y1 - 2006 PY - 2006 DA - 2006 SP - 2063 EP - 2069 VL - 69 IS - 23-24 SN - 1528-7394, 1528-7394 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Historical account KW - Antinuclear antibodies KW - Autoimmune diseases KW - Statistical analysis KW - USA, Southeast KW - Environmental factors KW - Dust KW - silica KW - Sunlight KW - Systemic lupus erythematosus KW - Occupational exposure KW - Races KW - Age composition KW - autoimmune diseases KW - sunlight KW - Hair KW - Silica KW - Dyes KW - Autoantibodies KW - Gender KW - Pesticides KW - Hair dyes KW - X 24310:Pharmaceuticals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20926315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Occupational+and+environmental+associations+with+antinuclear+antibodies+in+a+general+population+sample&rft.au=Cooper%2C+G+S%3BParks%2C+C+G%3BSchur%2C+P+S%3BFraser%2C+P+A&rft.aulast=Cooper&rft.aufirst=G&rft.date=2006-01-01&rft.volume=69&rft.issue=23-24&rft.spage=2063&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390600746165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antinuclear antibodies; Age composition; Autoimmune diseases; Statistical analysis; Environmental factors; Hair; Dust; Silica; Autoantibodies; Pesticides; Sunlight; Hair dyes; Systemic lupus erythematosus; Races; Occupational exposure; Historical account; Dyes; silica; Gender; autoimmune diseases; sunlight; USA, Southeast DO - http://dx.doi.org/10.1080/15287390600746165 ER - TY - JOUR T1 - Nitric Oxide Releasing Polyurethanes with Covalently Linked Diazeniumdiolated Secondary Amines AN - 20888270; 8018454 AB - Two novel strategies for synthesizing stable polyurethanes (PUs) capable of generating bioactive nitric oxide (NO) are described. The methods rely on covalently attaching diazeniumdiolate (N sub(2)O sub(2) super(-)) groups onto secondary amine nitrogens at various positions within the polymer chain such that, when in contact with water or physiological fluids, only the two molecules of NO available from each diazeniumdiolate moiety are released into the surrounding medium, with potential byproducts remaining covalently bound to the matrix. Extensive analysis of the NO sub(x) products released from the polymers was employed to develop appropriate strategies to better stabilize the diazeniumdiolate-based polymer structures. In one approach, diazeniumdiolate groups are attached to secondary amino nitrogens of alkane diamines inserted within the diol chain extender of a PU material. Oxidative loss of NO was minimized by blending the polymer with a biocompatible, relatively nonnucleophilic salt before exposing solutions of the polymer to NO during the diazeniumdiolation step. Fluxes of molecular NO from such materials during immersion in physiological buffer reached levels as high as 19 pmol cm super(-2).s super(-1) with a total recovery of 21 nmol of NO/mg of PU. A second general synthetic strategy involved omega-haloalkylating the urethane nitrogens and then displacing the halide from the resulting polymer with a nucleophilic polyamine to form a PU with pendent amino groups suitable for diazeniumdiolation. Commercially available Pellethane 2363-80AE that was bromobutylated and then reacted with diethylenetriamine and further exposed to gaseous NO proved stable in solid form for several months, but released NO with a total recovery of 17 nmol/mg upon immersion in physiological buffer. This material showed an initial NO flux of 14 pmol.cm super(-2).s super(-1) when immersed in pH 7.4 buffer at 37 degree C, with gradually decreasing but still observable fluxes for up to 6 days. JF - Biomacromolecules AU - Reynolds, Melissa M AU - Hrabie, Joseph A AU - Oh, Bong K AU - Politis, Jeffrey K AU - Citro, Michael L AU - Keefer, Larry K AU - Meyerhoff, Mark E AD - Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702 Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 987 EP - 994 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 7 IS - 3 SN - 1525-7797, 1525-7797 KW - Biotechnology and Bioengineering Abstracts KW - Alkanes KW - Salts KW - amines KW - Amino groups KW - polyamines KW - polyurethane KW - Immersion KW - Nitric oxide KW - urethane KW - pH effects KW - Nitrogen KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20888270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=Nitric+Oxide+Releasing+Polyurethanes+with+Covalently+Linked+Diazeniumdiolated+Secondary+Amines&rft.au=Reynolds%2C+Melissa+M%3BHrabie%2C+Joseph+A%3BOh%2C+Bong+K%3BPolitis%2C+Jeffrey+K%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BMeyerhoff%2C+Mark+E&rft.aulast=Reynolds&rft.aufirst=Melissa&rft.date=2006-01-01&rft.volume=7&rft.issue=3&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=15257797&rft_id=info:doi/10.1021%2Fbm060028oPII%3AS1525-7797%2806%2900028-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Alkanes; Salts; Amino groups; amines; polyamines; polyurethane; Immersion; Nitric oxide; pH effects; urethane; Nitrogen DO - http://dx.doi.org/10.1021/bm060028oPII:S1525-7797(06)00028-6 ER - TY - JOUR T1 - Short-term prediction of mortality in patients with systemic lupus erythematosus: Classification of outcomes using random forests AN - 20865260; 6693444 AB - Objective: To identify demographic and clinical characteristics that classify patients with systemic lupus erythematosus (SLE) at risk for in- hospital mortality. Methods: Patients hospitalized in California from 1996 to 2000 with a principal diagnosis of SLE (N = 3,839) were identified from a state hospitalization database. As candidate predictors of mortality, we used patient demographic characteristics; the presence or absence of 40 different clinical conditions listed among the discharge diagnoses; and 2 summary indexes derived from the discharge diagnoses, the Charlson Index and the SLE Comorbidity Index. Predictors of patients at increased risk of mortality were identified and validated using random forests, a statistical procedure that is a generalization of single classification trees. Random forests use bootstrapped samples of patients and randomly selected subsets of predictors to create individual classification trees, and this process is repeated to generate multiple trees (a forest). Classification is then done by majority vote across all trees. Results: Of the 3,839 patients, 109 died during hospitalization. Selecting from all available predictors, the random forests had excellent predictive accuracy for classification of death. The mean classification error rate, averaged over 10 forests of 500 trees each, was 11.9%. The most important predictors were the Charlson Index, respiratory failure, SLE Comorbidity Index, age, sepsis, nephritis, and thrombocytopenia. Conclusion: Information on clinical diagnoses can be used to accurately predict mortality among hospitalized patients with SLE. Random forests represent a useful technique to identify the most important predictors from a larger (often much larger) number and to validate the classification. JF - Arthritis Care & Research AU - Ward, Michael M AU - Pajevic, Sinisa AU - Dreyfuss, Jonathan AU - Malley, James D AD - National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, wardm1@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 74 EP - 80 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 55 IS - 1 SN - 0893-7524, 0893-7524 KW - Microbiology Abstracts B: Bacteriology KW - Systemic lupus erythematosus KW - Mortality KW - Hospitalization KW - Classification tree KW - Random forest KW - Age KW - Statistics KW - Forests KW - Demography KW - Databases KW - Sepsis KW - Thrombocytopenia KW - Classification KW - Nephritis KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20865260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Care+%26+Research&rft.atitle=Short-term+prediction+of+mortality+in+patients+with+systemic+lupus+erythematosus%3A+Classification+of+outcomes+using+random+forests&rft.au=Ward%2C+Michael+M%3BPajevic%2C+Sinisa%3BDreyfuss%2C+Jonathan%3BMalley%2C+James+D&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=55&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Arthritis+Care+%26+Research&rft.issn=08937524&rft_id=info:doi/10.1002%2Fart.21695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Mortality; Sepsis; Age; Thrombocytopenia; Statistics; Classification; Nephritis; Forests; Systemic lupus erythematosus; Hospitals DO - http://dx.doi.org/10.1002/art.21695 ER - TY - JOUR T1 - Inflammatory protein profile during systemic high dose interleukin-2 administration AN - 20865196; 6691346 AB - Systemic interleukin-2 (IL-2) administration induces an assortment of downstream effects whose biological and therapeutic significance remains unexplored mostly because of the methodological inability to globally address their complexity. Protein array analysis of sera from patients with renal cell carcinoma obtained prior and during high-dose IL-2 therapy had previously revealed extensive alterations in expression of the soluble factors analyzed, whose discovery was limited by the number of capture antibodies selected for protein detection. Here, we expanded the analysis to SELDI-TOF-MS and quantitative protein analysis (nephelometry). All cytokines/chemokines detected by protein arrays were below the SELDI detection limit, while novel IL-2- specific changes in expression of acute-phase reactants and high-density lipoprotein metabolites could be identified. Serum amyloid protein A (SAA) and C-reactive protein expression were consistently up-regulated after four doses of IL-2, while other proteins were down-regulated. These findings were confirmed by SELDI immunoaffinity capture and nephelometry. Immunoaffinity capture revealed different, otherwise undetectable, isoforms of SAA. A linear correlation between peak area by SELDI and protein concentration by nephelometry was observed. Overall distinct yet complementary information was obtained using different platforms, which may better illustrate complex phenomena such as the systemic response to biological response modifiers. JF - Proteomics AU - Rossi, Leonardo AU - Martin, Brian M AU - Hortin, Glen L AU - White, Richard L AU - Foster, Mareva AU - Moharram, Ramy AU - Stroncek, David AU - Wang, Ena AU - Marincola, Francesco M AU - Panelli, Monica C AD - Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy, mpanelli@mail.cc.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 709 EP - 720 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 6 IS - 2 SN - 1615-9853, 1615-9853 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Acute phase reactant KW - Interleukin-2 KW - Nephelometry KW - Renal cancer KW - SELDI-TOF MS KW - Chemokines KW - Interleukin 2 KW - Metabolites KW - Inflammation KW - Antibodies KW - renal cell carcinoma KW - Protein arrays KW - Lipoproteins KW - proteomics KW - C-reactive protein KW - Amyloid KW - F 06960:Molecular Immunology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20865196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Inflammatory+protein+profile+during+systemic+high+dose+interleukin-2+administration&rft.au=Rossi%2C+Leonardo%3BMartin%2C+Brian+M%3BHortin%2C+Glen+L%3BWhite%2C+Richard+L%3BFoster%2C+Mareva%3BMoharram%2C+Ramy%3BStroncek%2C+David%3BWang%2C+Ena%3BMarincola%2C+Francesco+M%3BPanelli%2C+Monica+C&rft.aulast=Rossi&rft.aufirst=Leonardo&rft.date=2006-01-01&rft.volume=6&rft.issue=2&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.200500004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nephelometry; Chemokines; Antibodies; renal cell carcinoma; Interleukin 2; Lipoproteins; Protein arrays; Metabolites; proteomics; Inflammation; Amyloid; C-reactive protein DO - http://dx.doi.org/10.1002/pmic.200500004 ER - TY - JOUR T1 - Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program AN - 20858757; 6660660 AB - BACKGROUND: Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease (CKD). We present an overview of the commonly used methods for the determination of serum creatinine, method limitations, and method performance in conjunction with the development of analytical performance criteria. Available resources for standardization of serum creatinine measurement are discussed, and recommendations for measurement improvement are given. METHODS: The National Kidney Disease Education Program (NKDEP) Laboratory Working Group reviewed problems related to serum creatinine measurement for estimating GFR and prepared recommendations to standardize and improve creatinine measurement. RESULTS: The NKDEP Laboratory Working Group, in collaboration with international professional organizations, has developed a plan that enables standardization and improved accuracy (trueness) of serum creatinine measurements in clinical laboratories worldwide that includes the use of the estimating equation for GFR based on serum creatinine concentration that was developed from the Modification of Diet in Renal Disease (MDRD) study. CONCLUSIONS: The current variability in serum creatinine measurements renders all estimating equations for GFR, including the MDRD Study equation, less accurate in the normal and slightly increased range of serum creatinine concentrations [<133 mu mol/L (1.5 mg/dL)], which is the relevant range for detecting CKD [<60 mL . min super(-1) . (1.73 m super(2)) super(-1)]. Many automated routine methods for serum creatinine measurement meet or exceed the required precision; therefore, reduction of analytical bias in creatinine assays is needed. Standardization of calibration does not correct for analytical interferences (nonspecificity bias). The bias and nonspecificity problems associated with some of the routine methods must be addressed. JF - Clinical Chemistry AU - Myers, Gary L AU - Miller, WGreg AU - Coresh, Josef AU - Fleming, James AU - Greenberg, Neil AU - Greene, Tom AU - Hostetter, Thomas AU - Levey, Andrew S AU - Panteghini, Mauro AU - Welch, Michael AU - Eckfeldt, John H AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA. Department of Pathology, Virginia Commonwealth University, Richmond, VA. Department of Epidemiology, Johns Hopkins University, Baltimore, MD. Department of Science and Technology, Laboratory Corporation of America, Elon, NC. Ortho Clinical Diagnostics, Rochester, NY. Department of Quantitative Health Science, Cleveland Clinic Foundation, Cleveland, OH. National Kidney Disease Education Program, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Division of Nephrology, Tufts New England Medical Center, Boston, MA. Department of Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy. Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 5 EP - 18 PB - American Association for Clinical Chemistry, Inc. VL - 52 IS - 1 SN - 0009-9147, 0009-9147 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Diets KW - Standardization KW - Creatinine KW - Mathematical models KW - Reviews KW - Kidney diseases KW - Glomerular filtration rate KW - Public health KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Recommendations+for+Improving+Serum+Creatinine+Measurement%3A+A+Report+from+the+Laboratory+Working+Group+of+the+National+Kidney+Disease+Education+Program&rft.au=Myers%2C+Gary+L%3BMiller%2C+WGreg%3BCoresh%2C+Josef%3BFleming%2C+James%3BGreenberg%2C+Neil%3BGreene%2C+Tom%3BHostetter%2C+Thomas%3BLevey%2C+Andrew+S%3BPanteghini%2C+Mauro%3BWelch%2C+Michael%3BEckfeldt%2C+John+H&rft.aulast=Myers&rft.aufirst=Gary&rft.date=2006-01-01&rft.volume=52&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Standardization; Mathematical models; Creatinine; Reviews; Kidney diseases; Glomerular filtration rate; Public health ER - TY - JOUR T1 - Natural and Synthetic Retinoids: Structural Bases and Biological Effects of Potential Clinical Relevance for the Prevention and Treatment of Infection-Driven Tumors AN - 20844128; 7668070 AB - Retinoids play a critical role in the regulation of cell division, growth, differentiation, and proliferation, and represent an exciting new avenue for targeted therapy of different diseases, including cancer. Natural and synthetic retinoids are also endowed with antiviral properties that make these compounds particularly attractive for the prevention and treatment of infection-driven tumors. In this review, we will summarize the structural bases and the cellular and antiviral effects of retinoids which provide a molecular basis for the management of virus-associated tumors, including Kaposi's sarcoma (HHV-8) and post-transplant lymphoproliferative disorders (EBV). Particular relevance will be given to the selectivity of these retinoids for their cognate receptors (RAR and RXR) in order to establish a link between receptor modulation and antiviral/antitumor effects. JF - Anti-Infective Agents in Medicinal Chemistry AU - Dolcetti, Riccardo AU - Luca, Dario D AU - de Lera, Angel R AD - Immunovirology and Biotherapy Unit, Department of Pre-clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Via Pedemontana Occidentale 12, 33081, Aviano (PN), Italy. Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 85 EP - 103 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 5 IS - 1 SN - 1871-5214, 1871-5214 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Retinoids KW - rexinoids KW - RARs KW - RXRs KW - epstein-barr virus KW - human herpesvirus 8 KW - human immunodeficiency virus KW - Immunoproliferative diseases KW - Differentiation KW - Epstein-Barr virus KW - Cell division KW - Kaposi's sarcoma KW - Human herpesvirus 8 KW - Reviews KW - Tumors KW - Retinoid X receptors KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-Infective+Agents+in+Medicinal+Chemistry&rft.atitle=Natural+and+Synthetic+Retinoids%3A+Structural+Bases+and+Biological+Effects+of+Potential+Clinical+Relevance+for+the+Prevention+and+Treatment+of+Infection-Driven+Tumors&rft.au=Dolcetti%2C+Riccardo%3BLuca%2C+Dario+D%3Bde+Lera%2C+Angel+R&rft.aulast=Dolcetti&rft.aufirst=Riccardo&rft.date=2006-01-01&rft.volume=5&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Anti-Infective+Agents+in+Medicinal+Chemistry&rft.issn=18715214&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoproliferative diseases; Differentiation; Cell division; Kaposi's sarcoma; Reviews; Tumors; Retinoids; Antitumor activity; Retinoid X receptors; Epstein-Barr virus; Human herpesvirus 8 ER - TY - JOUR T1 - Production and Characterization of Guinea Pig Recombinant Gamma Interferon and Its Effect on Macrophage Activation AN - 20833841; 6576907 AB - Gamma interferon (IFN- gamma ) plays a critical role in the protective immune responses against mycobacteria. We previously cloned a cDNA coding for guinea pig IFN- gamma (gpIFN- gamma ) and reported that BCG vaccination induced a significant increase in the IFN- gamma mRNA expression in guinea pig cells in response to living mycobacteria and that the virulent H37Rv strain of Mycobacterium tuberculosis stimulated less IFN- gamma mRNA than did the attenuated H37Ra strain. In this study, we successfully expressed and characterized recombinant gpIFN- gamma with a histidine tag at the N terminus (His-tagged rgpIFN- gamma ) in Escherichia coli. rgpIFN- gamma was identified as an 18-kDa band in the insoluble fraction; therefore, the protein was purified under denaturing conditions and renatured. N-terminal amino acid sequencing of the recombinant protein yielded the sequence corresponding to the N terminus of His-tagged gpIFN- gamma . The recombinant protein upregulated major histocompatibility complex class II expression in peritoneal macrophages. The antiviral activity of rgpIFN- gamma was demonstrated with a guinea pig fibroblast cell line (104C1) infected with encephalomyocarditis virus. Interestingly, peritoneal macrophages treated with rgpIFN- gamma did not produce any nitric oxide but did produce hydrogen peroxide and suppressed the intracellular growth of mycobacteria. Furthermore, rgpIFN- gamma induced morphological alterations in cultured macrophages. Thus, biologically active rgpIFN- gamma has been successfully produced and characterized in our laboratory. The study of rgpIFN- gamma will further increase our understanding of the cellular and molecular responses induced by BCG vaccination in the guinea pig model of pulmonary tuberculosis. JF - Infection and Immunity AU - Jeevan, A AU - McFarland, C T AU - Yoshimura, T AU - Skwor, T AU - Cho, H AU - Lasco, T AU - McMurray, D N AD - Texas A&M University SHSC, College Station, Texas 77843-1114. NCI-FCRDC, Frederick, Maryland 21702 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 213 EP - 224 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - guinea pigs KW - Virology & AIDS Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Encephalomyocarditis virus KW - Macrophages KW - gamma -Interferon KW - Molecular modelling KW - Peritoneum KW - Animal models KW - Major histocompatibility complex KW - Antiviral activity KW - Vaccination KW - Fibroblasts KW - Cell activation KW - Gene expression KW - cDNA KW - BCG KW - Hydrogen peroxide KW - Lung KW - Histidine KW - alpha -Interferon KW - Escherichia coli KW - Nitric oxide KW - Tuberculosis KW - Mycobacterium tuberculosis KW - Amino acid sequence KW - J 02831:Techniques and reagents KW - V 22350:Immunology KW - F 06100:Vaccines - active immunity KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20833841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Production+and+Characterization+of+Guinea+Pig+Recombinant+Gamma+Interferon+and+Its+Effect+on+Macrophage+Activation&rft.au=Jeevan%2C+A%3BMcFarland%2C+C+T%3BYoshimura%2C+T%3BSkwor%2C+T%3BCho%2C+H%3BLasco%2C+T%3BMcMurray%2C+D+N&rft.aulast=Jeevan&rft.aufirst=A&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Molecular modelling; gamma -Interferon; Peritoneum; Animal models; Major histocompatibility complex; Antiviral activity; Vaccination; Cell activation; Fibroblasts; Gene expression; Lung; Hydrogen peroxide; BCG; cDNA; Histidine; alpha -Interferon; Tuberculosis; Nitric oxide; Amino acid sequence; Encephalomyocarditis virus; Escherichia coli; Mycobacterium tuberculosis ER - TY - JOUR T1 - Kaposis sarcoma risk among transplant recipients in the United States (1993-2003) AN - 20723963; 7109123 AB - Kaposis sarcoma (KS) risk is high in immunosuppressed transplant recipients. KS develops in recipients with pre-existing infection with human herpesvirus 8 (HHV-8), the causative agent for KS, but it can also occur in recipients infected by donors. The relative importance of these sources of infection in recipients in the United States is unknown. We report recipient and donor characteristics associated with KS among transplant recipients in the United States. KS risk, after solid organ transplantation during 1993-2003, was analyzed using data from the Organ Procurement and Tissue Network. Associations were determined using proportional hazards regression. Sixtyfive KS cases were identified among 234,127 transplants (incidence 8.8 per 100,000 person-years). Most cases occurred in the first 2 years after transplantation (incidence 12.5 per 100,000 person-years). KS risk increased steadily with recipient age (p sub(trend) < 0.001) and was associated with the recipient being male (HR 1.8, 95% CI, 1.0-3.2), Hispanic (2.1, 1.1-3.8) and a non-U.S. citizen (3.9, 1.8- 8.6). Mismatch at the HLA-B locus, but not at HLA-A or HLA-DR loci, was associated with heightened risk (HR 3.6, 95%CI 1.1-11 for 1-2 vs. 0 HLA-B mismatches). KS was unrelated to donor characteristics and was not significantly related to use of specific antirejection medications. Our study found that KS incidence was low among transplant recipients in the United States, but it was associated with recipient age, sex and citizenship, perhaps reflecting pre- existing HHV-8 infection. The high KS risk immediately posttransplant and in persons with HLA-B mismatch highlights the role of immunosuppression and/or immune stimulation in KS pathogenesis. JF - International Journal of Cancer AU - Mbulaiteye, Sam M AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, mbulaits@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 2685 EP - 2691 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 11 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - human herpesvirus 8 KW - immunosuppression KW - cancer KW - chimerism KW - Histocompatibility antigen HLA KW - Age KW - Donors KW - Data processing KW - Human herpesvirus 8 KW - citizenship KW - Infection KW - Organs KW - Cancer KW - USA KW - Risk factors KW - infection KW - Sarcoma KW - Drugs KW - Ethnic groups KW - Immunosuppression KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Kaposis+sarcoma+risk+among+transplant+recipients+in+the+United+States+%281993-2003%29&rft.au=Mbulaiteye%2C+Sam+M%3BEngels%2C+Eric+A&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2006-01-01&rft.volume=119&rft.issue=11&rft.spage=2685&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Donors; Data processing; Risk factors; Sarcoma; Infection; Immunosuppression; Age; infection; citizenship; Drugs; Organs; Ethnic groups; Cancer; Human herpesvirus 8; USA DO - http://dx.doi.org/10.1002/ijc.22233 ER - TY - JOUR T1 - Neonatal Candidiasis Among Extremely Low Birth Weight Infants: Risk Factors, Mortality Rates, and Neurodevelopmental Outcomes at 18 to 22 Months AN - 20719186; 6662890 AB - BACKGROUND. Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported. METHODS. Data were collected prospectively for neonates born at 1 day after initiation of antifungal therapy), compared with infants whose catheters were removed or replaced promptly. CONCLUSIONS. Blood cultures were negative for approximately one half of the infants with Candida meningitis. Persistent candidiasis was common. Delayed catheter removal was associated with increased death and NDI rates. JF - Pediatrics AU - Benjamin, Daniel KJr AU - Stoll, Barbara J AU - Fanaroff, Avory A AU - McDonald, Scott A AU - Oh, William AU - Higgins, Rosemary D AU - Duara, Shahnaz AU - Poole, Kenneth AU - Laptook, Abbot AU - Goldberg, Ronald AD - Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina. Department of Pediatrics, Emory University, Atlanta, Georgia. Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, Ohio. Research Triangle Institute, Research Triangle Park, North Carolina. Brown University, Rhode Island Hospital, Providence, Rhode Island. National Institute of Child Health and Human Development, Bethesda, Maryland. University of Miami, Jackson Memorial Hospital, Miami, Florida Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 84 EP - 92 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 117 IS - 1 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts; CSA Neurosciences Abstracts KW - Blood culture KW - Neurodevelopmental disorders KW - Birth weight KW - Age KW - Candidemia KW - Candidiasis KW - low-birth-weight KW - feeding KW - Morbidity KW - Meningitis KW - Cerebrospinal fluid KW - Multivariate analysis KW - Risk factors KW - birth weight KW - medical instruments KW - Cephalosporins KW - Mortality KW - Data processing KW - Enteral feeding KW - Candida KW - Gender KW - Catheters KW - Neonates KW - Infants KW - K 03400:Human Diseases KW - R2 23060:Medical and environmental health KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20719186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Neonatal+Candidiasis+Among+Extremely+Low+Birth+Weight+Infants%3A+Risk+Factors%2C+Mortality+Rates%2C+and+Neurodevelopmental+Outcomes+at+18+to+22+Months&rft.au=Benjamin%2C+Daniel+KJr%3BStoll%2C+Barbara+J%3BFanaroff%2C+Avory+A%3BMcDonald%2C+Scott+A%3BOh%2C+William%3BHiggins%2C+Rosemary+D%3BDuara%2C+Shahnaz%3BPoole%2C+Kenneth%3BLaptook%2C+Abbot%3BGoldberg%2C+Ronald&rft.aulast=Benjamin&rft.aufirst=Daniel&rft.date=2006-01-01&rft.volume=117&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; Blood culture; Birth weight; Mortality; Cephalosporins; Age; Data processing; Candidiasis; Candidemia; Enteral feeding; Morbidity; Meningitis; Cerebrospinal fluid; Multivariate analysis; Risk factors; Catheters; Neonates; Infants; Gender; low-birth-weight; feeding; birth weight; medical instruments; Candida ER - TY - JOUR T1 - The Forkhead Transcription Factor FoxI1 Remains Bound to Condensed Mitotic Chromosomes and Stably Remodels Chromatin Structure AN - 20715306; 6580212 AB - All forkhead (Fox) proteins contain a highly conserved DNA binding domain whose structure is remarkably similar to the winged-helix structures of histones H1 and H5. Little is known about Fox protein binding in the context of higher-order chromatin structure in living cells. We created a stable cell line expressing FoxI1-green fluorescent protein (GFP) or FoxI1-V5 fusion proteins under control of the reverse tetracycline-controlled transactivator doxycycline inducible system and found that unlike most transcription factors, FoxI1 remains bound to the condensed chromosomes during mitosis. To isolate DNA fragments directly bound by the FoxI1 protein within living cells, we performed chromatin immunoprecipitation assays (ChIPs) with antibodies to either enhanced GFP or the V5 epitope and subcloned the FoxI1-enriched DNA fragments. Sequence analyses indicated that 88% (106/121) of ChIP sequences contain the consensus binding sites for all Fox proteins. Testing ChIP sequences with a quantitative DNase I hypersensitivity assay showed that FoxI1 created stable DNase I sensitivity changes in condensed chromosomes. The majority of ChIP targets and random targets increased in resistance to DNase I in FoxI1-expressing cells, but a small number of targets became more accessible to DNase I. Consistently, the accessibility of micrococcal nuclease to chromatin was generally inhibited. Micrococcal nuclease partial digestion generated a ladder in which all oligonucleosomes were slightly longer than those observed with the controls. On the basis of these findings, we propose that FoxI1 is capable of remodeling chromatin higher-order structure and can stably create site-specific changes in chromatin to either stably create or remove DNase I hypersensitive sites. JF - Molecular and Cellular Biology AU - Yan, Jizhou AU - Xu, Lisha AU - Crawford, Gregory AU - Wang, Zenfeng AU - Burgess, Shawn M AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 155 EP - 168 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 26 IS - 1 SN - 0270-7306, 0270-7306 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - FOX protein KW - Chromatin remodeling KW - Chromatin KW - Immunoprecipitation KW - Nuclease KW - Forkhead protein KW - Antibodies KW - Chromosomes KW - Transcription factors KW - Mitosis KW - DNA KW - Conserved sequence KW - Deoxyribonuclease KW - Fusion protein KW - Doxycycline KW - Histone H1 KW - Epitopes KW - N 14025:RNA/DNA role in infection & immune response KW - J 02320:Cell Biology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20715306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=The+Forkhead+Transcription+Factor+FoxI1+Remains+Bound+to+Condensed+Mitotic+Chromosomes+and+Stably+Remodels+Chromatin+Structure&rft.au=Yan%2C+Jizhou%3BXu%2C+Lisha%3BCrawford%2C+Gregory%3BWang%2C+Zenfeng%3BBurgess%2C+Shawn+M&rft.aulast=Yan&rft.aufirst=Jizhou&rft.date=2006-01-01&rft.volume=26&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - FOX protein; Chromatin; Chromatin remodeling; Immunoprecipitation; Nuclease; Forkhead protein; Chromosomes; Antibodies; Mitosis; Transcription factors; DNA; Conserved sequence; Deoxyribonuclease; Fusion protein; Epitopes; Histone H1; Doxycycline ER - TY - JOUR T1 - Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis AN - 20714053; 6711308 AB - Several single nucleotide polymorphisms (SNPs) in genes derived from distinct pathways are associated with colon cancer risk; however, few studies have examined SNP-SNP interactions concurrently. We explored the association between colon cancer and 94 SNPs, using a novel approach, polymorphism interaction analysis (PIA). We developed PIA to examine all possible SNP combinations, based on the 94 SNPs studied in 216 male colon cancer cases and 255 male controls, employing 2 separate functions that crossvalidate and minimize false-positive results in the evaluation of SNP combinations to predict colon cancer risk. PIA identified previously described null polymorphisms in glutathione-S-transferase T1 (GSTT1) as the best predictor of colon cancer among the studied SNPs, and also identified novel polymorphisms in the inflammation and hormone metabolism pathways that singly or jointly predict cancer risk. PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer. This was confirmed by logistic regression, as the GSTT1 null polymorphism in combination with either the TP53 or the CASP8 polymorphism significantly alter colon cancer risk (p sub(interaction) < 0.02 for both). GSTT1 prevents DNA damage by detoxifying mutagenic compounds, while the p53 protein facilitates repair of DNA damage and induces apoptosis, and caspase 8 is activated in p53-mediated apoptosis. Our results suggest that PIA is a valid method for suggesting SNP-SNP interactions that may be validated in future studies, using more traditional statistical methods on different datasets (Supplementary material can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat JF - International Journal of Cancer AU - Goodman, Julie E AU - Mechanic, Leah E AU - Luke, Brian T AU - Ambs, Stefan AU - Chanock, Stephen AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA, Curtis_Harris@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1790 EP - 1797 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 7 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - polymorphism interaction analysis single nucleotide polymorphism colon cancer KW - DNA KW - Proteins KW - Hormones KW - Cancer KW - Metabolism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20714053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Exploring+SNP-SNP+interactions+and+colon+cancer+risk+using+polymorphism+interaction+analysis&rft.au=Goodman%2C+Julie+E%3BMechanic%2C+Leah+E%3BLuke%2C+Brian+T%3BAmbs%2C+Stefan%3BChanock%2C+Stephen%3BHarris%2C+Curtis+C&rft.aulast=Goodman&rft.aufirst=Julie&rft.date=2006-01-01&rft.volume=118&rft.issue=7&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21523 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA; Proteins; Hormones; Metabolism; Cancer DO - http://dx.doi.org/10.1002/ijc.21523 ER - TY - JOUR T1 - Cancer Informatics Vision: caBIGac AN - 20664615; 9420435 JF - Cancer Informatics AU - von Eschenbach, Andrew C AU - Buetow, Kenneth AD - Director, National Cancer Institute Y1 - 2006 PY - 2006 DA - 2006 SP - 22 EP - 24 PB - Libertas Academica, PO Box 300-874 VL - 2 SN - 1176-9351, 1176-9351 KW - Biotechnology and Bioengineering Abstracts KW - Informatics KW - Vision KW - Cancer KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20664615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Informatics&rft.atitle=Cancer+Informatics+Vision%3A+caBIGac&rft.au=von+Eschenbach%2C+Andrew+C%3BBuetow%2C+Kenneth&rft.aulast=von+Eschenbach&rft.aufirst=Andrew&rft.date=2006-01-01&rft.volume=2&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Cancer+Informatics&rft.issn=11769351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vision; Informatics; Cancer ER - TY - JOUR T1 - Structural studies of algal lectins with anti-HIV activity AN - 20540554; 8054090 AB - A number of antiviral lectins, small proteins that bind carbohydrates found on viral envelopes, are currently in pre-clinical trials as potential drugs for prevention of transmission of human immunodeficiency virus (HIV) and other enveloped viruses, such as the Ebola virus and the coronavirus responsible for severe acute respiratory syndrome (SARS). Lectins of algal origin whose antiviral properties make them candidate agents for prevention of viral transmission through topical applications include cyanovirin-N, Microcystis viridis lectin, scytovirin, and griffithsin. Although all these proteins exhibit significant antiviral activity, their structures are unrelated and their mode of binding of carbohydrates differs significantly. This review summarizes the current state of knowledge of the structures of algal lectins, their mode of binding of carbohydrates, and their potential medical applications. JF - Acta Biochimica Polonica AU - Ziolkowska, N E AU - Wlodawer, A AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 617 EP - 626 VL - 53 IS - 4 SN - 0001-527X, 0001-527X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Severe acute respiratory syndrome KW - Ebola virus KW - Lectins KW - Antiviral activity KW - Disease transmission KW - Topical application KW - cyanovirin-N KW - Envelopes KW - Microcystis viridis KW - Antiviral agents KW - Human immunodeficiency virus KW - Reviews KW - Carbohydrates KW - SARS coronavirus KW - Algae KW - K 03340:Effects of Physical & Chemical Factors KW - V 22340:Antiviral Agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20540554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biochimica+Polonica&rft.atitle=Structural+studies+of+algal+lectins+with+anti-HIV+activity&rft.au=Ziolkowska%2C+N+E%3BWlodawer%2C+A&rft.aulast=Ziolkowska&rft.aufirst=N&rft.date=2006-01-01&rft.volume=53&rft.issue=4&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Acta+Biochimica+Polonica&rft.issn=0001527X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - cyanovirin-N; Envelopes; Antiviral agents; Reviews; Severe acute respiratory syndrome; Lectins; Carbohydrates; Antiviral activity; Algae; Topical application; Disease transmission; Microcystis viridis; Human immunodeficiency virus; Ebola virus; SARS coronavirus ER - TY - JOUR T1 - Are antibodies to the capsular polysaccharide of Neisseria meningitidis group B and Escherichia coli K1 associated with immunopathology? AN - 20447681; 6965971 AB - As polysialic acid (PSA), the capsule of Group B meningococcus (GBM) and Escherichia coli K1, is a component of mammalian glycopeptides, there is concern that vaccines against PSA could induce immunopathology. Purified PSA is not immunogenic; however, as a component of bacteria or bound to proteins, it induces protective antibodies. In this review, we did not unearth data indicating an association of IgG anti-PSA with immunopathology in experimental animals or humans. We found no increased incidence of autoimmunity from GBM infections in our review of the natural history/sequellae of Neisseria meningitis infections. Accordingly, we propose that clinical trials of PSA conjugate vaccines, be considered. JF - Vaccine AU - Stein, Daniel M AU - Robbins, John AU - Miller, Mark A AU - Lin, Feng-Ying C AU - Schneerson, Rachel AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, USA, millermark@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 221 EP - 228 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 3 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Vaccine KW - Autoimmunity KW - Polysialic acid (poly alpha (2 --> 8) N-acetylneuraminic acid) KW - Neisseria meningitidis KW - Antibody response KW - Infection KW - Polysaccharides KW - Clinical trials KW - Meningitis KW - Glycopeptides KW - Reviews KW - Escherichia coli KW - Immunoglobulin G KW - Vaccines KW - polysialic acid KW - F 06100:Vaccines - active immunity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20447681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Are+antibodies+to+the+capsular+polysaccharide+of+Neisseria+meningitidis+group+B+and+Escherichia+coli+K1+associated+with+immunopathology%3F&rft.au=Stein%2C+Daniel+M%3BRobbins%2C+John%3BMiller%2C+Mark+A%3BLin%2C+Feng-Ying+C%3BSchneerson%2C+Rachel&rft.aulast=Stein&rft.aufirst=Daniel&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.07.084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Glycopeptides; Reviews; Immunoglobulin G; Autoimmunity; Antibody response; polysialic acid; Vaccines; Polysaccharides; Infection; Clinical trials; Meningitis; Escherichia coli; Neisseria meningitidis DO - http://dx.doi.org/10.1016/j.vaccine.2005.07.084 ER - TY - JOUR T1 - The fluorescence protease protection (FPP) assay to determine protein localization and membrane topology AN - 20400581; 7632437 AB - Correct localization and topology are crucial for the cellular function of a protein. To determine the topology of membrane proteins, a new technique, called the fluorescence protease protection (FPP) assay, can be applied. This assay uses the restricted proteolytic digestibility of GFP- tagged transmembrane proteins to indicate their intramembrane orientation. The sole requirements for FPP are the expression of GFP fusion proteins and the selective permeabilization of the plasma membrane, which permits a wide range of cell types and organelles to be investigated. The FPP assay can be carried out in a straightforward manner to obtain reliable results within minutes. Here we provide a step-by-step protocol for the assay. As an example, we use FPP to determine which terminus of an endoplasmic reticulum (ER) transmembrane protein is lumenal and which one is facing the cytosol. JF - Nature Protocols AU - Lorenz, Holger AU - Hailey, Dale W AU - Wunder, Christian AU - Lippincott-Schwartz, Jennifer AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 18T Library Drive, Bethesda, Maryland 20892, USA., holgerl@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 276 EP - 279 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 1 IS - 1 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Endoplasmic reticulum KW - Fluorescence KW - Plasma membranes KW - Digestibility KW - Cytosol KW - Proteinase KW - Fusion protein KW - Membrane proteins KW - Organelles KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20400581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=The+fluorescence+protease+protection+%28FPP%29+assay+to+determine+protein+localization+and+membrane+topology&rft.au=Lorenz%2C+Holger%3BHailey%2C+Dale+W%3BWunder%2C+Christian%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Lorenz&rft.aufirst=Holger&rft.date=2006-01-01&rft.volume=1&rft.issue=1&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2006.42 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Membrane proteins; Proteinase; Fluorescence; Endoplasmic reticulum; Cytosol; Organelles; Digestibility; Proteolysis; Fusion protein; Plasma membranes DO - http://dx.doi.org/10.1038/nprot.2006.42 ER - TY - JOUR T1 - ZAP-70 in CLL: Towards standardization of a biomarker for patient management: History of clinical cytometry special issue AN - 20400324; 7014993 JF - Cytometry Part B AU - Marti, Gerald AU - Orfao, Alberto AU - Goolsby, Chuck AD - FDA, Bethesda, Maryland, gemarti@helix.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 197 EP - 200 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 70B IS - 4 SN - 1552-4949, 1552-4949 KW - Biotechnology and Bioengineering Abstracts KW - CLL KW - ZAP-70 KW - flow cytometry KW - ZAP-70 protein KW - Standardization KW - Chronic lymphatic leukemia KW - biomarkers KW - Cytometry KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20400324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=ZAP-70+in+CLL%3A+Towards+standardization+of+a+biomarker+for+patient+management%3A+History+of+clinical+cytometry+special+issue&rft.au=Marti%2C+Gerald%3BOrfao%2C+Alberto%3BGoolsby%2C+Chuck&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2006-01-01&rft.volume=70B&rft.issue=4&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524949&rft_id=info:doi/10.1002%2Fcyto.b.20137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - ZAP-70 protein; Standardization; biomarkers; Chronic lymphatic leukemia; Cytometry DO - http://dx.doi.org/10.1002/cyto.b.20137 ER - TY - JOUR T1 - Streptococcal Receptor Polysaccharides: Recognition Molecules for Oral Biofilm Formation AN - 20356600; 9030303 AB - Background Strains of viridans group streptococci that initiate colonization of the human tooth surface typically coaggregate with each other and with Actinomyces naeslundii, another member of the developing biofilm community. These interactions generally involve adhesin-mediated recognition of streptococcal receptor polysaccharides (RPS). The objective of our studies is to understand the role of these polysaccharides in oral biofilm development. Methods Different structural types of RPS have been characterized by their reactions with specific antibodies and lectin-like adhesins. Streptococcal gene clusters for RPS biosynthesis were identified, sequenced, characterized and compared. RPS-producing bacteria were detected in biofilm samples using specific antibodies and gene probes. Results Six different types of RPS have been identified from representative viridans group streptococci that coaggregate with A. naeslundii. Each type is composed of a different hexa- or heptasaccharide repeating unit, the structures of which contain host-like motifs, either GalNAc beta 1-3Gal or Gal beta 1-3GalNAc. These motifs account for RPS-mediated recognition, whereas other features of these polysaccharides are more closely associated with RPS antigenicity. The RPS-dependent interaction of S. oralis with A. naeslundii promotes growth of these bacteria and biofilm formation in flowing saliva. Type specific differences in RPS production have been noted among the resident streptococcal floras of different individuals, raising the possibility of RPS-based differences in the composition of oral biofilm communities. Conclusion The structural, functional and molecular properties of streptococcal RPS support a recognition role of these cell surface molecules in oral biofilm formation. JF - BMC Oral Health AU - Yoshida, Yasuo AU - Palmer, Robert J AU - Yang, Jinghua AU - Kolenbrander, Paul E AU - Cisar, John O AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4352, USA, yasuoy@iwate-med.ac.jp Y1 - 2006 PY - 2006 DA - 2006 SP - S12 PB - BioMed Central Ltd., Middlesex House VL - 6 IS - Suppl 1 SN - 1472-6831, 1472-6831 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Teeth KW - Cell surface KW - Adhesins KW - Antigenicity KW - Probes KW - Polysaccharides KW - Actinomyces naeslundii KW - Colonization KW - Antibodies KW - Structure-function relationships KW - Gene clusters KW - Biofilms KW - Saliva KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20356600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Oral+Health&rft.atitle=Streptococcal+Receptor+Polysaccharides%3A+Recognition+Molecules+for+Oral+Biofilm+Formation&rft.au=Yoshida%2C+Yasuo%3BPalmer%2C+Robert+J%3BYang%2C+Jinghua%3BKolenbrander%2C+Paul+E%3BCisar%2C+John+O&rft.aulast=Yoshida&rft.aufirst=Yasuo&rft.date=2006-01-01&rft.volume=6&rft.issue=Suppl+1&rft.spage=S12&rft.isbn=&rft.btitle=&rft.title=BMC+Oral+Health&rft.issn=14726831&rft_id=info:doi/10.1186%2F1472-6831-6-S1-S12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Teeth; Adhesins; Cell surface; Colonization; Antibodies; Structure-function relationships; Antigenicity; Gene clusters; Probes; Saliva; Biofilms; Polysaccharides; Streptococcus; Actinomyces naeslundii DO - http://dx.doi.org/10.1186/1472-6831-6-S1-S12 ER - TY - JOUR T1 - Development of Novel Therapeutic Strategies for Lung Cancer: Targeting the Cholinergic System AN - 20284272; 7653250 AB - One of the earliest descriptions of non-neuronal ACh synthesis was by Morris who reported that ACh was synthesized in the placenta [1]; furthermore, Falugi et al. showed the presence of AChE in human fibrosarcoma cells [2]. Afterward, the expression of ACh, AChE, and cholinergic receptors in non-neuronal cells was reported in several studies [3-16]. Indeed, recent data reported that SCLC expresses a cholinergic autocrine loop that can regulate cell growth. Such work demonstrates that SCLC cells have a cholinergic phenotype and that ACh exerts as an autocrine growth factor in human lung tumours [16]. Moreover, it has been recently reported that nicotine in lung adenocarcinoma A549 cells, potently induces Bad phosphorylation at serine (S)112, S136 and S155 in a mechanism involving activation of MAPKs, ERK1/2, PI3K/AKT and PKA through the linking to alpha 7- receptors [9]. Bad phosphorylation results in sequestering Bad from mitochondria and subsequently interacting with 14-3-3 in the cytosol [9]. We have recently reported that human malignant pleural mesothelioma expresses a cholinergic system, involved in cell growth regulation. Hence, mesothelioma cells growth is modulated by the cholinergic system in which agonists (i.e. nicotine) have a proliferative effect and antagonists (i.e. curare or alpha - cobratoxin) have an inhibitory effect. Furthermore apoptosis mechanisms are under the control of the cholinergic system (nicotine antiapoptotic via induction of NF- Kappa B complexes and phosphorylation of Bad at S112, curare proapoptotic via G0-G1 arrest p21waf-1-dependent, but p53- independent) [16]. The involvement of the non-neuronal cholinergic system in lung cancer and mesothelioma appears reasonable and opens up new translational research strategies. JF - Current Medicinal Chemistry AU - Russo, P AU - Catassi, A AU - Cesario, A AU - Servent, D AD - Department of Integrated Medical Oncology (DOMI), Laboratory of Translational Research B (Lung Cancer), National Cancer Institute, Genoa, Largo Rosanna Benzi 10, I-16132 Genoa Italy. Y1 - 2006 PY - 2006 DA - 2006 SP - 3493 EP - 3512 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 13 IS - 29 SN - 0929-8673, 0929-8673 KW - Biotechnology and Bioengineering Abstracts KW - Non-neuronal cholinergic system KW - neurotoxins KW - lung cancer KW - mesothelioma KW - cell growth KW - Fibrosarcoma KW - Translation KW - Protein kinase A KW - Apoptosis KW - Mitochondria KW - Antagonists KW - NF- Kappa B protein KW - Extracellular signal-regulated kinase KW - 1-Phosphatidylinositol 3-kinase KW - Autocrine signalling KW - Phosphorylation KW - Nicotine KW - Placenta KW - AKT protein KW - Growth factors KW - Serine KW - Lung cancer KW - MAP kinase KW - Tumors KW - Acetylcholine receptors KW - 14-3-3 protein KW - Cytosol KW - Acetylcholine KW - Adenocarcinoma KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20284272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medicinal+Chemistry&rft.atitle=Development+of+Novel+Therapeutic+Strategies+for+Lung+Cancer%3A+Targeting+the+Cholinergic+System&rft.au=Russo%2C+P%3BCatassi%2C+A%3BCesario%2C+A%3BServent%2C+D&rft.aulast=Russo&rft.aufirst=P&rft.date=2006-01-01&rft.volume=13&rft.issue=29&rft.spage=3493&rft.isbn=&rft.btitle=&rft.title=Current+Medicinal+Chemistry&rft.issn=09298673&rft_id=info:doi/10.2174%2F092986706779026192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Fibrosarcoma; Protein kinase A; Apoptosis; Mitochondria; Antagonists; NF- Kappa B protein; Extracellular signal-regulated kinase; Autocrine signalling; 1-Phosphatidylinositol 3-kinase; Phosphorylation; Nicotine; Placenta; AKT protein; Growth factors; Serine; Lung cancer; MAP kinase; Tumors; Acetylcholine receptors; Cytosol; 14-3-3 protein; mesothelioma; Acetylcholine; Adenocarcinoma DO - http://dx.doi.org/10.2174/092986706779026192 ER - TY - JOUR T1 - Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse AN - 20262884; 7281426 AB - A major goal of drug abuse research is to identify and understand drug- induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine if different drugs of abuse effect changes in gene expression that converge in common molecular pathways. Microarray analysis was employed to assay brain gene expression in postmortem anterior prefrontal cortex x28; aPFCx29; from 42 human cocaine, cannabis and/or phencyclidine abuse cases and 30 control cases, which were characterized by toxicology and drug abuse history. Common transcriptional changes were demonstrated for a majority of drug abuse cases x28; N src="corehtml/pmc/pmcents/thinsp.gif" border="0" alt=" " />x3d; src="corehtml/pmc/pmcents/thinsp.gif" border="0" alt=" " />34x29; , representing a number of consistently changed functional classes: Calmodulin- related transcripts x28; CALM1, CALM2, CAMK2Bx29; were decreased, while transcripts related to cholesterol biosynthesis and trafficking x28; FDFT1, APOL2, SCARB1x29; , and Golgi/endoplasmic reticulum x28; ERx29; functions x28; SEMA3B, GCC1x29; were all increased. Quantitative PCR validated decreases in calmodulin 2 x28; CALM2x29; mRNA and increases in apolipoprotein L, 2 x28; APOL2x29; and semaphorin 3B x28; SEMA3Bx29; mRNA for individual cases. A comparison between control cases with and without cardiovascular disease and elevated body mass index indicated that these changes were not due to general cellular and metabolic stress, but appeared specific to the use of drugs. Therefore, humans who abused cocaine, cannabis and/or phencyclidine share a decrease in transcription of calmodulin-related genes and increased transcription related to lipid/cholesterol and Golgi/ER function. These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers. JF - PLoS ONE AU - Lehrmann, Elin AU - Colantuoni, Carlo AU - Deep-Soboslay, Amy AU - Becker, Kevin G AU - Lowe, Ross AU - Huestis, Marilyn A AU - Hyde, Thomas M AU - Kleinman, Joel E AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 IS - 1 SN - 1932-6203, 1932-6203 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Article No. e114 KW - Golgi apparatus KW - Apolipoproteins KW - Lipids KW - Plasticity (synaptic) KW - Drug abuse KW - DNA microarrays KW - Gene expression KW - Endoplasmic reticulum KW - Cannabis KW - Polymerase chain reaction KW - Drug addiction KW - Cocaine KW - Calcium-binding protein KW - Brain KW - Transcription KW - Stress KW - Cholesterol KW - Drug dependence KW - Decision making KW - Phencyclidine KW - Calmodulin KW - Cardiovascular diseases KW - Body mass index KW - semaphorins KW - Cortex (prefrontal) KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20262884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Transcriptional+Changes+Common+to+Human+Cocaine%2C+Cannabis+and+Phencyclidine+Abuse&rft.au=Lehrmann%2C+Elin%3BColantuoni%2C+Carlo%3BDeep-Soboslay%2C+Amy%3BBecker%2C+Kevin+G%3BLowe%2C+Ross%3BHuestis%2C+Marilyn+A%3BHyde%2C+Thomas+M%3BKleinman%2C+Joel+E%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2006-01-01&rft.volume=1&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0000114. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Golgi apparatus; Apolipoproteins; Lipids; Drug abuse; Plasticity (synaptic); DNA microarrays; Gene expression; Endoplasmic reticulum; Cannabis; Polymerase chain reaction; Cocaine; Drug addiction; Calcium-binding protein; Brain; Stress; Transcription; Cholesterol; Decision making; Drug dependence; Phencyclidine; Calmodulin; Cardiovascular diseases; Body mass index; semaphorins; Cortex (prefrontal) DO - http://dx.doi.org/10.1371/journal.pone.0000114. ER - TY - JOUR T1 - A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action AN - 20245098; 7155060 AB - Background All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have been previously implicated in a novel form of DNA repair on the basis of comparative analysis of their protein product sequences. However, the proximity of CRISPR and cas genes strongly suggests that they have related functions which is hard to reconcile with the repair hypothesis. Results The protein sequences of the numerous cas gene products were classified into similar to 25 distinct protein families; several new functional and structural predictions are described. Comparative-genomic analysis of CRISPR and cas genes leads to the hypothesis that the CRISPR-Cas system (CASS) is a mechanism of defense against invading phages and plasmids that functions analogously to the eukaryotic RNA interference (RNAi) systems. Specific functional analogies are drawn between several components of CASS and proteins involved in eukaryotic RNAi, including the double-stranded RNA-specific helicase-nuclease (dicer), the endonuclease cleaving target mRNAs (slicer), and the RNA-dependent RNA polymerase. However, none of the CASS components is orthologous to its apparent eukaryotic functional counterpart. It is proposed that unique inserts of CRISPR, some of which are homologous to fragments of bacteriophage and plasmid genes, function as prokaryotic siRNAs (psiRNA), by base-pairing with the target mRNAs and promoting their degradation or translation shutdown. Specific hypothetical schemes are developed for the functioning of the predicted prokaryotic siRNA system and for the formation of new CRISPR units with unique inserts encoding psiRNA conferring immunity to the respective newly encountered phages or plasmids. The unique inserts in CRISPR show virtually no similarity even between closely related bacterial strains which suggests their rapid turnover, on evolutionary scale. Corollaries of this finding are that, even among closely related prokaryotes, the most commonly encountered phages and plasmids are different and/or that the dominant phages and plasmids turn over rapidly. Conclusion We proposed previously that Cas proteins comprise a novel DNA repair system. The association of the cas genes with CRISPR and, especially, the presence, in CRISPR units, of unique inserts homologous to phage and plasmid genes make us abandon this hypothesis. It appears most likely that CASS is a prokaryotic system of defense against phages and plasmids that functions via the RNAi mechanism. The functioning of this system seems to involve integration of fragments of foreign genes into archaeal and bacterial chromosomes yielding heritable immunity to the respective agents. However, it appears that this inheritance is extremely unstable on the evolutionary scale such that the repertoires of unique psiRNAs are completely replaced even in closely related prokaryotes, presumably, in response to rapidly changing repertoires of dominant phages and plasmids. This article was reviewed by: Eric Bapteste, Patrick Forterre, and Martijn Huynen. Open peer review Reviewed by Eric Bapteste, Patrick Forterre, and Martijn Huynen. For the full reviews, please go to the Reviewers' comments section. JF - Biology Direct AU - Makarova, Kira S AU - Grishin, Nick V AU - Shabalina, Svetlana A AU - Wolf, Yuri I AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1745-6150, 1745-6150 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Article No. 7 KW - Phages KW - Genomes KW - Translation KW - Heredity KW - Immune system KW - protein families KW - Immunity KW - DNA repair KW - Plasmids KW - Computer applications KW - Integration KW - Chromosomes KW - DNA-directed RNA polymerase KW - siRNA KW - Structure-function relationships KW - Palindromes KW - RNA-directed RNA polymerase KW - Reviews KW - Cellular apoptosis susceptibility protein KW - RNA-mediated interference KW - Prokaryotes KW - Endonuclease KW - Evolution KW - J 02310:Genetics & Taxonomy KW - V 22320:Replication KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20245098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=A+putative+RNA-interference-based+immune+system+in+prokaryotes%3A+computational+analysis+of+the+predicted+enzymatic+machinery%2C+functional+analogies+with+eukaryotic+RNAi%2C+and+hypothetical+mechanisms+of+action&rft.au=Makarova%2C+Kira+S%3BGrishin%2C+Nick+V%3BShabalina%2C+Svetlana+A%3BWolf%2C+Yuri+I%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=17456150&rft_id=info:doi/10.1186%2F1745-6150-1-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Phages; Translation; Heredity; Immune system; protein families; Immunity; Computer applications; Plasmids; DNA repair; Integration; DNA-directed RNA polymerase; Chromosomes; siRNA; Palindromes; Structure-function relationships; Reviews; RNA-directed RNA polymerase; Cellular apoptosis susceptibility protein; RNA-mediated interference; Prokaryotes; Endonuclease; Evolution DO - http://dx.doi.org/10.1186/1745-6150-1-7 ER - TY - JOUR T1 - Use of serial ultrasound to identify periods of fetal growth restriction in relation to neonatal anthropometry AN - 20240549; 7092788 AB - The developmental origins of the health and disease hypothesis suggests that fetal growth restriction (FGR) is a risk factor for several chronic diseases of adulthood. However, most supporting studies use birth weight as a proxy measure of FGR. To examine the relationship between birth weight and FGR, the present study used serial prenatal ultrasound to identify periods of FGR during gestation, and related these periods to birth size and shape. The data in this study included serial prenatal ultrasounds performed on 1,349 high-risk Scandinavian women enrolled in the National Institute of Child Health and Human Development Study of Successive Small for Gestational Age Births. Fetal growth velocity between ultrasounds was used to identify periods of isolated FGR, and these were studied in relation to anthropometry at birth. FGR was identified in 184 subjects. A control group of 384 subjects without FGR was also identified. Infants with first-trimester FGR (n = 20) had the highest birth weight, ponderal index, and subscapular skinfold thickness. Infants with second- trimester FGR (n = 37) had the highest arm fat percentage. Infants with early third-trimester FGR (n = 55) had the lowest mean birth weight and ponderal index. When infant gender, gestational age, maternal body mass index, and smoking were controlled, birth weight was predicted only by third-trimester FGR (not first- or second-trimester FGR), and arm fat percent was predicted only by second-trimester FGR. These results suggest that birth weight is not a valid indicator of FGR occurring before the third trimester. Body composition may be a more sensitive marker of early FGR. Am. J. Hum. Biol. 18:791-797, 2006. Published 2006 Wiley-Liss, Inc. JF - American Journal of Human Biology AU - Hemachandra, Anusha H AU - Klebanoff, Mark A AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, hemachaa@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 791 EP - 797 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 18 IS - 6 SN - 1042-0533, 1042-0533 KW - Biotechnology and Bioengineering Abstracts KW - Birth weight KW - Data processing KW - Gestational age KW - Skinfold thickness KW - Fetuses KW - Anthropometry KW - Ponderal index KW - Smoking KW - Risk factors KW - Risk groups KW - Neonates KW - Body composition KW - Body mass index KW - Ultrasound KW - Infants KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Biology&rft.atitle=Use+of+serial+ultrasound+to+identify+periods+of+fetal+growth+restriction+in+relation+to+neonatal+anthropometry&rft.au=Hemachandra%2C+Anusha+H%3BKlebanoff%2C+Mark+A&rft.aulast=Hemachandra&rft.aufirst=Anusha&rft.date=2006-01-01&rft.volume=18&rft.issue=6&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Biology&rft.issn=10420533&rft_id=info:doi/10.1002%2Fajhb.20552 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Birth weight; Gestational age; Data processing; Skinfold thickness; Fetuses; Ponderal index; Anthropometry; Smoking; Risk factors; Risk groups; Neonates; Body mass index; Body composition; Ultrasound; Infants DO - http://dx.doi.org/10.1002/ajhb.20552 ER - TY - JOUR T1 - PilZ domain is part of the bacterial c-di-GMP binding protein AN - 20230014; 6666383 AB - Recent studies identified c-di-GMP as a universal bacterial secondary messenger regulating biofilm formation, motility, production of extracellular polysaccharide and multicellular behavior in diverse bacteria. However, except for cellulose synthase, no protein has been shown to bind c-di-GMP and the targets for c-di-GMP action remain unknown. Here we report identification of the PilZ ('pills') domain (Pfam domain PF07238) in the sequences of bacterial cellulose synthases, alginate biosynthesis protein Alg44, proteins of enterobacterial YcgR and firmicute YpfA families, and other proteins encoded in bacterial genomes and present evidence indicating that this domain is (part of) the long-sought c-di-GMP-binding protein. Association of the PilZ domain with a variety of other domains, including likely components of bacterial multidrug secretion system, could provide clues to multiple functions of the c-di-GMP in bacterial pathogenesis and cell development. Supplementary information: http://www.ncbi.nlm.nih.gov/Complete_Genomes/SigCensus/PilZ.html JF - Bioinformatics AU - Amikam, Dorit AU - Galperin, Michael Y AD - Department of Biotechnology and Environmental Sciences, Tel-Hai Academic College Tel-Hai, Israel. Sharett Institute of Oncology, Hadassah University Medical Center Ein-Kerem, Jerusalem, Israel. National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 3 EP - 6 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 1 SN - 1367-4803, 1367-4803 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Bacteria KW - Motility KW - Protein biosynthesis KW - Alginic acid KW - Secretion KW - cellulose synthase KW - Firmicutes KW - Bioinformatics KW - Biofilms KW - Polysaccharides KW - A 01310:Products of Microorganisms KW - J 02320:Cell Biology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20230014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=PilZ+domain+is+part+of+the+bacterial+c-di-GMP+binding+protein&rft.au=Amikam%2C+Dorit%3BGalperin%2C+Michael+Y&rft.aulast=Amikam&rft.aufirst=Dorit&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Motility; Protein biosynthesis; Alginic acid; Secretion; cellulose synthase; Biofilms; Bioinformatics; Polysaccharides; Bacteria; Firmicutes ER - TY - JOUR T1 - WholePathwayScope: a comprehensive pathway-based analysis tool for high- throughput data AN - 20226726; 6730822 AB - Analysis of High Throughput (HTP) Data such as microarray and proteomics data has provided a powerful methodology to study patterns of gene regulation at genome scale. A major unresolved problem in the post-genomic era is to assemble the large amounts of data generated into a meaningful biological context. We have developed a comprehensive software tool, WholePathwayScope (WPS), for deriving biological insights from analysis of HTP data. WPS extracts gene lists with shared biological themes through color cue templates. WPS statistically evaluates global functional category enrichment of gene lists and pathway-level pattern enrichment of data. WPS incorporates well- known biological pathways from KEGG (Kyoto Encyclopedia of Genes and Genomes) and Biocarta, GO (Gene Ontology) terms as well as user-defined pathways or relevant gene clusters or groups, and explores gene-term relationships within the derived gene-term association networks (GTANs). WPS simultaneously compares multiple datasets within biological contexts either as pathways or as association networks. WPS also integrates Genetic Association Database and Partial MedGene Database for disease-association information. We have used this program to analyze and compare microarray and proteomics datasets derived from a variety of biological systems. Application examples demonstrated the capacity of WPS to significantly facilitate the analysis of HTP data for integrative discovery. This tool represents a pathway-based platform for discovery integration to maximize analysis power. The tool is freely available at http://www.abcc.ncifcrf.gov/wps/wps_index.php. JF - BMC Bioinformatics AU - Yi, Ming AU - Horton, Jay D AU - Cohen, Jonathan C AU - Hobbs, Helen H AU - Stephens, Robert M AD - Advanced Biomedical Computing Center, National Cancer Institute- Frederick/SAIC-Frederick Inc., Frederick, MD 21702, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 30 KW - Genomes KW - GO gene KW - Data processing KW - double prime GO gene KW - Color KW - Integration KW - Databases KW - Computer programs KW - software KW - Gene regulation KW - Gene clusters KW - Bioinformatics KW - proteomics KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=WholePathwayScope%3A+a+comprehensive+pathway-based+analysis+tool+for+high-+throughput+data&rft.au=Yi%2C+Ming%3BHorton%2C+Jay+D%3BCohen%2C+Jonathan+C%3BHobbs%2C+Helen+H%3BStephens%2C+Robert+M&rft.aulast=Yi&rft.aufirst=Ming&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-30 L2 - http://www.biomedcentral.com/1471-2105/7/30 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; GO gene; Data processing; double prime GO gene; Color; Computer programs; Databases; Integration; software; Gene regulation; Gene clusters; proteomics; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-7-30 ER - TY - JOUR T1 - Nitration and Inactivation of IDO by Peroxynitrite AN - 20129215; 6577983 AB - IDO induction can deplete L-tryptophan in target cells, an effect partially responsible for the antimicrobial activities and antiallogeneic T cell responses of IFN- gamma in human macrophages, dendritic cells, and bone marrow cells. L-Tryptophan depletion and NO production are both known to have an antimicrobial effect in macrophages, and the interaction of these two mechanisms is unclear. In this study we found that IDO activity was inhibited by the peroxynitrite generator, 3-(4-morpholinyl)sydnonimine, in PMA-differentiated cytokine-induced THP-1 (acute monocytic leukemia) cells and IFN- gamma -stimulated PBMCs, whereas IDO protein expression was unaffected compared with that in untreated cells. Nitrotyrosine was detected in immunoprecipitated (IP)-IDO from PMA-differentiated cytokine-induced THP-1 cells treated with 3-(4-morpholinyl)sydnonimine, but not from untreated cells. Treatment of IP-IDO and recombinant IDO (rIDO) with peroxynitrite significantly decreased enzyme activity. Nitrotyrosine was detected in both peroxynitrite-treated IP-IDO and rIDO, but not in either untreated IP-IDO or rIDO. Peptide analysis by liquid chromatography/electrospray ionization and tandem mass spectrometry demonstrated that Tyr super(15), Tyr super(345), and Tyr super(353) in rIDO were nitrated by peroxynitrite. The levels of Tyr nitration and the inhibitory effect of peroxynitrite on IDO activity were significantly reduced in the Tyr super(15)-to-Phe mutant. These results indicate that IDO is nitrated and inactivated by peroxynitrite and that nitration of Tyr super(15) in IDO protein is the most important factor in the inactivation of IDO. JF - Journal of Immunology AU - Fujigaki, Hidetsugu AU - Saito, Kuniaki AU - Lin, Felix AU - Fujigaki, Suwako AU - Takahashi, Kanako AU - Martin, Brian M AU - Chen, Cai Y AU - Masuda, Junichi AU - Kowalak, Jeffrey AU - Takikawa, Osamu AU - Seishima, Mitsuru AU - Markey, Sanford P AD - Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu City, Japan. Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892. Department of Pharmacology, Hokkaido University, Sapporo, Japan Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 372 EP - 379 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 1 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Macrophages KW - gamma -Interferon KW - Antimicrobial activity KW - nitrotyrosine KW - Peroxynitrite KW - Bone marrow KW - Enzymes KW - Mass spectroscopy KW - Antimicrobial agents KW - Dendritic cells KW - Tryptophan oxygenase KW - Acute monocytic leukemia KW - Liquid chromatography KW - L-Tryptophan KW - Nitration KW - Lymphocytes T KW - Nitric oxide KW - A 01340:Antibiotics & Antimicrobials KW - F 06512:Immunopharmacology and general Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20129215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Nitration+and+Inactivation+of+IDO+by+Peroxynitrite&rft.au=Fujigaki%2C+Hidetsugu%3BSaito%2C+Kuniaki%3BLin%2C+Felix%3BFujigaki%2C+Suwako%3BTakahashi%2C+Kanako%3BMartin%2C+Brian+M%3BChen%2C+Cai+Y%3BMasuda%2C+Junichi%3BKowalak%2C+Jeffrey%3BTakikawa%2C+Osamu%3BSeishima%2C+Mitsuru%3BMarkey%2C+Sanford+P&rft.aulast=Fujigaki&rft.aufirst=Hidetsugu&rft.date=2006-01-01&rft.volume=176&rft.issue=1&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Antimicrobial activity; nitrotyrosine; Peroxynitrite; Bone marrow; Enzymes; Mass spectroscopy; Antimicrobial agents; Dendritic cells; Acute monocytic leukemia; Tryptophan oxygenase; Liquid chromatography; L-Tryptophan; Lymphocytes T; Nitration; Nitric oxide ER - TY - JOUR T1 - Human alpha -defensins block papillomavirus infection AN - 20120287; 6662763 AB - Sexually transmitted human papillomaviruses (HPVs) are the primary cause of cervical cancer. Recent advances in techniques for production of papillomaviral vectors [known as pseudoviruses (PsVs)] have made it possible to perform high-throughput screens for compounds that might block the initial stages of papillomavirus infection. We have used PsVs to screen a variety of compounds that might function as inhibitors of HPV infection, with emphasis on human peptides previously implicated in innate antimicrobial immunity. Little is known about the possible activity of these peptides against nonenveloped viruses, such as HPVs. Our screen revealed that human alpha -defensins 1-3 [known as human neutrophil peptides (HNPs) 1-3] and human alpha -defensin 5 (HD-5) are potent antagonists of infection by both cutaneous and mucosal papillomavirus types. In contrast, human beta -defensins 1 and 2 displayed little or no anti-HPV activity. HD-5 was particularly active against sexually transmitted HPV types, with 50% inhibitory doses in the high ng/ml range. Microscopic studies of PsV inhibition by the alpha -defensins revealed that they block virion escape from endocytic vesicles but not virion binding or internalization. Consistent with this finding, PsVs remained susceptible to inhibition by alpha -defensins for many hours after initial binding to cells. HNPs 1-3 and HD-5 have been reported to be present in the female genital tract at levels that overlap those that inhibit HPVs in vitro, suggesting that they could present a natural barrier to the sexual transmission of HPV and could serve as the basis of a broad-spectrum topical microbicide. JF - Proceedings of the National Academy of Sciences, USA AU - Buck, Christopher B AU - Day, Patricia M AU - Thompson, Cynthia D AU - Lubkowski, Jacek AU - Lu, Wuyuan AU - Lowy, Douglas R AU - Schiller, John T AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4263 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1516 EP - 1521 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 5 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Mucosa KW - Cervical cancer KW - Leukocytes (neutrophilic) KW - Vectors KW - Immunity KW - Infection KW - Antagonists KW - Disease transmission KW - Antimicrobial agents KW - Defensins KW - Genital tract KW - Vesicles KW - Papillomavirus KW - Human papillomavirus KW - microbicides KW - A 01340:Antibiotics & Antimicrobials KW - V 22100:Antiviral agents KW - F 06910:Microorganisms & Parasites KW - V 22114:Human oncogenic viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20120287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Human+alpha+-defensins+block+papillomavirus+infection&rft.au=Buck%2C+Christopher+B%3BDay%2C+Patricia+M%3BThompson%2C+Cynthia+D%3BLubkowski%2C+Jacek%3BLu%2C+Wuyuan%3BLowy%2C+Douglas+R%3BSchiller%2C+John+T&rft.aulast=Buck&rft.aufirst=Christopher&rft.date=2006-01-01&rft.volume=103&rft.issue=5&rft.spage=1516&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Cervical cancer; Mucosa; Leukocytes (neutrophilic); Vectors; Immunity; Infection; Antagonists; Antimicrobial agents; Disease transmission; Defensins; Vesicles; Genital tract; microbicides; Papillomavirus; Human papillomavirus ER - TY - JOUR T1 - Viral proteomics: A promising approach for understanding JC virus tropism AN - 19995630; 7113128 AB - The human polyomavirus JC virus (JCV) is responsible for the CNS demyelination observed in cases of progressive multifocal leukoencephalopathy. The JCV regulatory region (promoter) is a hypervariable, noncoding, nucleotide sequence positioned between the early and late protein-coding regions in the viral genome. Selective binding of cellular transcription factors to this promoter region participates in the control of viral tropism. Hence, further study of these proteins might provide new insights into JCV tropism and associated pathogenesis. This review gives an overview of viral proteomics-the study of all proteins expressed from the viral gene transcripts, and all the cellular proteins that play a role in JCV tropism. It also describes a new biochemical approach for studying relevant JCV promoter-binding proteins, which is an anchored-JCV transcriptional promoter (ATP) assay. An ATP assay utilizes the product of PCR-amplified JCV promoter sequences coupled with Sepharose beads in order to capture and isolate cellular nuclear proteins with specific promoter-binding affinity for analysis. Proteins that bind to JCV-ATPs can be eluted and subjected to proteomic analysis. Insights from this approach may improve the understanding of viral and cellular parameters that control JCV tropism. JF - Proteomics AU - Ravichandran, Veerasamy AU - Major, Eugene O AD - Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and e, National Institutes of Health, Bethesda, MD, USA, ravichanr@ninds.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 5628 EP - 5636 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 6 IS - 20 SN - 1615-9853, 1615-9853 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Anchored-JCV-Promoter JC virus Proteomics technologies KW - Genomes KW - Central nervous system KW - Regulatory sequences KW - Nucleotide sequence KW - Tropism KW - ATP KW - Polyomavirus KW - Demyelination KW - Progressive multifocal leukoencephalopathy KW - JC virus KW - Promoters KW - Transcription factors KW - Reviews KW - proteomics KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19995630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Viral+proteomics%3A+A+promising+approach+for+understanding+JC+virus+tropism&rft.au=Ravichandran%2C+Veerasamy%3BMajor%2C+Eugene+O&rft.aulast=Ravichandran&rft.aufirst=Veerasamy&rft.date=2006-01-01&rft.volume=6&rft.issue=20&rft.spage=5628&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.200600261 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Central nervous system; Promoters; Nucleotide sequence; Reviews; Regulatory sequences; Transcription factors; Tropism; ATP; Demyelination; proteomics; Progressive multifocal leukoencephalopathy; Polyomavirus; JC virus DO - http://dx.doi.org/10.1002/pmic.200600261 ER - TY - JOUR T1 - Asthma history, occupational exposure to pesticides and the risk of non- Hodgkin's lymphoma AN - 19986084; 6736188 AB - We previously reported that, although asthma did not increase the risk of non-Hodgkin's lymphoma (NHL), the risk from pesticide exposures was higher among asthmatics than that among nonasthmatics. To further evaluate this finding, we analyzed data from a population-based case-control study of NHL conducted in Iowa, Detroit, Los Angeles and Seattle. Cases (n = 668) diagnosed with NHL from 1998 to 2000 and controls (n = 543) randomly selected from the same geographical areas as that of the cases were included in this analysis. Odds ratios (OR) for the risk of NHL from potential occupational exposure to pesticides tended to be higher among asthmatics (OR = 1.7; 95% CI 0.3-9.1) when compared with that among nonasthmatics (OR = 0.9; 95% CI 0.6-1.5). The risks of NHL associated with pesticide exposure were also higher among asthmatics who had history of hospitalization (OR = 2.1; 95% CI 0.2-29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics. JF - International Journal of Cancer AU - Lee, Won Jin AU - Purdue, Mark P AU - Stewart, Patricia AU - Schenk, Maryjean AU - De Roos, Anneclaire J AU - Cerhan, James R AU - Severson, Richard K AU - Cozen, Wendy AU - Hartge, Patricia AU - Blair, Aaron AD - Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea, blaira@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3174 EP - 3176 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - asthma non-Hodgkin's lymphoma pesticide exposure KW - Non-Hodgkin's lymphoma KW - Hodgkin's disease KW - Data processing KW - Pesticides KW - Asthma KW - Respiratory diseases KW - Lymphoma KW - Occupational exposure KW - R2 23080:Industrial and labor KW - F 06915:Cancer Immunology KW - H 1000:Occupational Safety and Health KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Asthma+history%2C+occupational+exposure+to+pesticides+and+the+risk+of+non-+Hodgkin%27s+lymphoma&rft.au=Lee%2C+Won+Jin%3BPurdue%2C+Mark+P%3BStewart%2C+Patricia%3BSchenk%2C+Maryjean%3BDe+Roos%2C+Anneclaire+J%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BCozen%2C+Wendy%3BHartge%2C+Patricia%3BBlair%2C+Aaron&rft.aulast=Lee&rft.aufirst=Won&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3174&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21755 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Non-Hodgkin's lymphoma; Data processing; Hodgkin's disease; Pesticides; Asthma; Occupational exposure; Respiratory diseases; Lymphoma DO - http://dx.doi.org/10.1002/ijc.21755 ER - TY - JOUR T1 - Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter? AN - 19980250; 7382524 AB - It is generally accepted that allogeneic stem cell transplantation can `cure chronic myelogenous leukemia (CML), although occasional patients relapse more than 10 years after the transplant procedure. Such cures presumably result from the combined effects of leukemia stem cells (LSCs) of the conditioning regimen and the graft-vs.-leukemia (GvL) effect mediated by donor-derived T lymphocytes. The advent of imatinib has revolutionized the management of patients with CML, but much evidence suggests that it does not eradicate all LSCs, which theoretically remain a potential source of relapse to chronic phase or advanced phase disease. Moreover, sub-clones of Philadelphia-positive cells bearing mutations that code for amino-acid substitutions in the Bcr-Abl kinase domain can be identified in patients receiving treatment with imatinib and are associated with varying degrees of resistance to this agent. In the present review, we postulate that LSCs, similar to their normal counterparts, may alternate between cycling and quiescent modes. In the cycling mode, they may express Bcr-Abl protein and be susceptible to the acquisition of additional mutations, whereas, in the quiescent mode, they may express little or no Bcr-Abl oncoprotein, cannot acquire additional mutations and are unaffected by imatinib. Thus, a patient who starts treatment early in the natural history of CML, and who responds to imatinib clinically, may not have had the opportunity to acquire additional mutations in LSCs. In this case, the persistence long-term of quiescent `non-mutated LSCs despite imatinib treatment might be consistent with freedom from relapse to chronic or advanced phase disease, provided that they remain vulnerable to imatinib when they are recruited into cycle. Conversely, when imatinib resistant Philadelphia-positive sub-clones predominate, this is likely to be due to the recruitment to hematopoiesis of quiescent stem cells that had been in cycle before administration of imatinib and that had acquired additional mutations; in such cases, the best approach to eradication of residual LSCs might be to target expressed proteins thought to be targets for the GvL effect. JF - Leukemia & Lymphoma AU - Goldman, John AU - Gordon, Myrtle AD - Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1 EP - 7 PB - Taylor & Francis Ltd., 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 47 IS - 1 SN - 1042-8194, 1042-8194 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - CML KW - stem cells KW - SCT KW - imatinib KW - mutations KW - Chronic myeloid leukemia KW - Amino acid substitution KW - stem cell transplantation KW - Abl protein KW - BCR protein KW - Imatinib KW - Stem cells KW - Lymphocytes T KW - Hemopoiesis KW - Fusion protein KW - Mutation KW - Lymphoma KW - W 30940:Products KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+Lymphoma&rft.atitle=Why+do+chronic+myelogenous+leukemia+stem+cells+survive+allogeneic+stem+cell+transplantation+or+imatinib%3A+does+it+really+matter%3F&rft.au=Goldman%2C+John%3BGordon%2C+Myrtle&rft.aulast=Goldman&rft.aufirst=John&rft.date=2006-01-01&rft.volume=47&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+Lymphoma&rft.issn=10428194&rft_id=info:doi/10.1080%2F10428190500407996 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Imatinib; Chronic myeloid leukemia; Stem cells; Amino acid substitution; stem cell transplantation; Lymphocytes T; Abl protein; Hemopoiesis; Fusion protein; Lymphoma; Mutation; BCR protein DO - http://dx.doi.org/10.1080/10428190500407996 ER - TY - JOUR T1 - Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling AN - 19968378; 7281339 AB - POU transcription factor Pou5f1 x28; Oct3/4x29; is required to maintain ES cells in an undifferentiated state. Here we show that global expression profiling of Oct3/4-manipulated ES cells delineates the downstream target genes of Oct3/4. Combined with data from genome-wide chromatin-immunoprecipitation x28; ChIPx29; assays, this analysis identifies not only primary downstream targets of Oct3/4, but also secondary or tertiary targets. Furthermore, the analysis also reveals that downstream target genes are regulated either positively or negatively by Oct3/4. Identification of a group of genes that show both activation and repression depending on Oct3/4 expression levels provides a possible mechanism for the requirement of appropriate Oct3/4 expression to maintain undifferentiated ES cells. As a proof-of-principle study, one of the downstream genes, Tcl1, has been analyzed in detail. We show that Oct3/4 binds to the promoter region of Tcl1 and activates its transcription. We also show that Tcl1 is involved in the regulation of proliferation, but not differentiation, in ES cells. These findings suggest that the global expression profiling of gene-manipulated ES cells can help to delineate the structure and dynamics of gene regulatory networks. JF - PLoS ONE AU - Matoba, Ryo AU - Niwa, Hitoshi AU - Masui, Shinji AU - Ohtsuka, Satoshi AU - Carter, Mark G AU - Sharov, Alexei A AU - Ko, Minoru SH AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 IS - 1 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. e26 KW - Promoters KW - Differentiation KW - Stem cells KW - Data processing KW - Embryo cells KW - Transcription factors KW - Oct-4 protein KW - Cell proliferation KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19968378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Dissecting+Oct3%2F4-Regulated+Gene+Networks+in+Embryonic+Stem+Cells+by+Expression+Profiling&rft.au=Matoba%2C+Ryo%3BNiwa%2C+Hitoshi%3BMasui%2C+Shinji%3BOhtsuka%2C+Satoshi%3BCarter%2C+Mark+G%3BSharov%2C+Alexei+A%3BKo%2C+Minoru+SH&rft.aulast=Matoba&rft.aufirst=Ryo&rft.date=2006-01-01&rft.volume=1&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0000026. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Promoters; Stem cells; Data processing; Embryo cells; Transcription factors; Cell proliferation; Oct-4 protein DO - http://dx.doi.org/10.1371/journal.pone.0000026. ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 19966969; 6580290 AB - In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Retroviral Genotyping Tools, HIV-1, Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Kenton, David L AU - Khovayko, Oleg AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Schriml, Lynn M AU - Sequeira, Edwin AU - Sherry, Stephen T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Suzek, Tugba O AU - Tatusov, Roman AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - D173 EP - D180 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 34 SN - 0305-1048, 0305-1048 KW - HIV-1 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - DNA probes KW - Genotyping KW - Cancer KW - Gene expression KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - N 14020:DNA/RNA genomics sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19966969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BKenton%2C+David+L%3BKhovayko%2C+Oleg%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSchriml%2C+Lynn+M%3BSequeira%2C+Edwin%3BSherry%2C+Stephen+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BSuzek%2C+Tugba+O%3BTatusov%2C+Roman%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2006-01-01&rft.volume=34&rft.issue=&rft.spage=D173&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; Genotyping; DNA probes; Cancer; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 ER - TY - JOUR T1 - The NHLBI Lymphangioleiomyomatosis Registry: Characteristics of 230 Patients at Enrollment AN - 199648953; 16210669 AB - Pulmonary lymphangioleiomyomatosis is a progressive cystic lung disease that is associated with infiltration of atypical smooth muscle-like cells. Previous descriptions of clinical characteristics of subjects with lymphangioleiomyomatosis have been based on a limited number of patients. To describe the clinical characteristics of subjects with pulmonary lymphangioleiomyomatosis, both sporadic and tuberous sclerosis-related forms. Over a 3-yr period, from 1998 to 2001, 243 subjects with pulmonary lymphangioleiomyomatosis were enrolled into a national registry; 13 subjects who had already undergone lung transplantation were excluded for the purposes of this report. All 230 subjects were women, aged 18 to 76 yr (mean +/- SE, 44.5 +/- 0.65 yr). The average age at onset of symptoms was 38.9 +/- 0.73 yr and at diagnosis was 41.0 +/- 0.65 yr. Tuberous sclerosis complex was present in 14.8% of subjects. Pulmonary manifestations, most commonly spontaneous pneumothorax, were the primary events leading to the diagnosis in 86.5% of cases. Nearly 55% of the subjects were being treated with a progesterone derivative. An obstructive pattern on pulmonary function testing was observed in 57.3% of the subjects, whereas 33.9% had normal spirometric results. Women with tuberous sclerosis-related lymphangioleiomyomatosis were younger and had less impaired lung function compared with those with the sporadic form. The age range of women afflicted with pulmonary lymphangioleiomyomatosis is broader than previously appreciated and the degree of pulmonary function can be quite variable, with one-third of subjects having normal spirometry at enrollment into this registry. JF - American Journal of Respiratory and Critical Care Medicine AU - Ryu, Jay H AU - Moss, Joel AU - Beck, Gerald J AU - Jar-Chi, Lee AU - et al Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 105 EP - 11 CY - New York PB - American Thoracic Society VL - 173 IS - 1 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Respiratory Function Tests KW - Humans KW - Adult KW - Quality of Life KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Registries KW - Lung Diseases -- diagnosis KW - Lung Diseases -- epidemiology KW - Lymphangioleiomyomatosis -- epidemiology KW - Lymphangioleiomyomatosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199648953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=The+NHLBI+Lymphangioleiomyomatosis+Registry%3A+Characteristics+of+230+Patients+at+Enrollment&rft.au=Ryu%2C+Jay+H%3BMoss%2C+Joel%3BBeck%2C+Gerald+J%3BJar-Chi%2C+Lee%3Bet+al&rft.aulast=Ryu&rft.aufirst=Jay&rft.date=2006-01-01&rft.volume=173&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Jan 1, 2006 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: Comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging AN - 19964123; 6735464 AB - Sentinel node imaging is commonly performed prior to surgery for breast cancer and melanoma. While current methods are based on radio- lymphoscintigraphy, MR lymphangiography (MRL) offers the benefits of better spatial resolution without ionizing radiation. However, the optimal nanoparticle for imaging the sentinel nodes remains unclear. Gadolinium-labeled (Gd) contrast agents ranging in diameter from - 1 to 12 nm were evaluated to determine which size provides the most rapid and most concentrated delivery of contrast agent to the lymph nodes in a mouse model of lymphatic metastases. Specifically, PAMAM- G2, -G4, -G6 and -G8, and DAB-G5 Gd-dendrimer agents, as well as Gadomer-17 and Gd-DTPA, were compared. Among these agents, the G6 Gd dendrimer depicted the lymphatics and lymph nodes with the highest peak concentrations and this occurred 24-36 min post-injection (p - 0.01; all except G8). Based on ex vivo concentration phantoms, high accumulations of Gd(III) ions occurred within lymph nodes (1.7-4.4 mM Gd/270-680 ppm Gd) with high target to background ratios (> 100). These concentrations are sufficient to contemplate the use of Gd- neutron capture therapy of regional lymph nodes. Thus, when injected interstitially, the PAMAM-G6 Gd dendrimer not only provides excellent opacification of sentinel lymph nodes, but also provides the potential for targeted therapy of sentinel lymph nodes. JF - Journal of Controlled Release AU - Kobayashi, Hisataka AU - Kawamoto, Satomi AU - Bernardo, Marcelino AU - Brechbiel, Martin W AU - Knopp, Michael V AU - Choyke, Peter L AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, MSC1088, 10 Center Drive, Bethesda, MD 20892-1088, United States, Kobayash@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 343 EP - 351 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 111 IS - 3 SN - 0168-3659, 0168-3659 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Gadolinium KW - Animal models KW - spatial discrimination KW - Melanoma KW - Lymphangiography KW - Metastases KW - Surgery KW - Contrast media KW - Ions KW - Controlled release KW - Lymph nodes KW - Neutrons KW - Ionizing radiation KW - Breast cancer KW - nanoparticles KW - W 30910:Imaging KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Delivery+of+gadolinium-labeled+nanoparticles+to+the+sentinel+lymph+node%3A+Comparison+of+the+sentinel+node+visualization+and+estimations+of+intra-nodal+gadolinium+concentration+by+the+magnetic+resonance+imaging&rft.au=Kobayashi%2C+Hisataka%3BKawamoto%2C+Satomi%3BBernardo%2C+Marcelino%3BBrechbiel%2C+Martin+W%3BKnopp%2C+Michael+V%3BChoyke%2C+Peter+L&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2006-01-01&rft.volume=111&rft.issue=3&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/10.1016%2Fj.jconrel.2005.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Lymph nodes; nanoparticles; Animal models; Contrast media; Controlled release; Surgery; Gadolinium; Ionizing radiation; Breast cancer; spatial discrimination; Lymphangiography; Neutrons; Ions; Metastases; Melanoma; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.jconrel.2005.12.019 ER - TY - JOUR T1 - Flow cytometry for ZAP-70: New colors for chronic lymphocytic leukemia AN - 19963281; 7014994 AB - ZAP-70 has become one of the most studied prognostic markers in Chronic Lymphocytic Leukemia (CLL). ZAP-70 is remarkable in many ways: ZAP-70 has been identified as the best discriminating gene between prognostically distinct CLL subtypes using large scale gene expression profiling; ZAP-70 has been shown to enhance signal transduction in CLL B-cells and therefore could contribute to disease progression; and ZAP-70 is one of the rare examples of an intracellular target considered for clinical flow cytometry. This issue attests to the enormous effort and the steady progress made in overcoming technical challenges of testing for ZAP-70 expression and sets the foundation for a successful translation of this important marker into clinical practice. Despite the best effort, one will likely have to accept that not all cases can be clearly assigned to one or the other group, given that ZAP-70 expression between CLL patients falls along a continuum from absent to high. Nevertheless, ZAP-70 expression could become a key parameter to guide patients towards risk adapted treatment strategies in prospective clinical trials. JF - Cytometry Part B AU - Wiestner, Adrian AD - Hematology Branch, NHLBI, NIH, Bethesda, Maryland, wiestnera@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 201 EP - 203 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 70B IS - 4 SN - 1552-4949, 1552-4949 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - ZAP-70 KW - chronic lymphocytic leukemia KW - prognostic marker KW - flow cytometry KW - ZAP-70 protein KW - Flow cytometry KW - Gene expression KW - Translation KW - Lymphocytes B KW - Chronic lymphatic leukemia KW - Clinical trials KW - Color KW - Signal transduction KW - W 30905:Medical Applications KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19963281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=Flow+cytometry+for+ZAP-70%3A+New+colors+for+chronic+lymphocytic+leukemia&rft.au=Wiestner%2C+Adrian&rft.aulast=Wiestner&rft.aufirst=Adrian&rft.date=2006-01-01&rft.volume=70B&rft.issue=4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524949&rft_id=info:doi/10.1002%2Fcyto.b.20126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Flow cytometry; ZAP-70 protein; Translation; Lymphocytes B; Clinical trials; Chronic lymphatic leukemia; Signal transduction; Color DO - http://dx.doi.org/10.1002/cyto.b.20126 ER - TY - JOUR T1 - Bone Marrow Lacks a Transplantable Progenitor for Smooth Muscle Type alpha -Actin-Expressing Cells AN - 19960942; 6665909 AB - While some studies have suggested that hematopoietic stem cells might give rise to other tissue types, others indicate that transdifferentiation would have to be an extremely rare event. We have now exploited smooth muscle type alpha -actin ( alpha SMA) promoter- driven green fluorescent protein (GFP) transgenic mice ( alpha SMA-GFP mice) for bone marrow transplantation to evaluate their potential to generate donor-type tissues in irradiation chimeras. There was a highly restricted pattern of GFP expression in the transgenic mice, marking bone marrow stromal cells and mesangial cells in the kidney. However, these characteristics were not transferable to wild-type animals given transgenic marrow cells even though hematopoietic cells were largely replaced. Our findings support earlier studies suggesting that the bone marrow microenvironment is difficult to transplant and indicate that hematopoietic stem cells are unlikely to give rise to alpha SMA-expressing progeny. JF - Stem Cells AU - Yokota, Takafumi AU - Kawakami, Yutaka AU - Nagai, Yoshinori AU - Ma, Jian-xing AU - Tsai, Jen-Yue AU - Kincade, Paul W AU - Sato, Sanai AD - Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma. Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma. National Eye Institute, NIH, Bethesda, Maryland, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 13 EP - 22 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 1 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Smooth muscle KW - stromal cells KW - Bone marrow KW - Green fluorescent protein KW - Transgenic mice KW - Transgenic animals KW - Chimeras KW - Stem cells KW - Radiation KW - Allografts KW - Kidney KW - Hemopoiesis KW - Microenvironments KW - Actin KW - Progeny KW - Mesangial cells KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Bone+Marrow+Lacks+a+Transplantable+Progenitor+for+Smooth+Muscle+Type+alpha+-Actin-Expressing+Cells&rft.au=Yokota%2C+Takafumi%3BKawakami%2C+Yutaka%3BNagai%2C+Yoshinori%3BMa%2C+Jian-xing%3BTsai%2C+Jen-Yue%3BKincade%2C+Paul+W%3BSato%2C+Sanai&rft.aulast=Yokota&rft.aufirst=Takafumi&rft.date=2006-01-01&rft.volume=24&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smooth muscle; stromal cells; Green fluorescent protein; Bone marrow; Transgenic mice; Transgenic animals; Chimeras; Stem cells; Radiation; Allografts; Kidney; Microenvironments; Hemopoiesis; Progeny; Actin; Mesangial cells ER - TY - JOUR T1 - The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate? AN - 19959080; 7154611 AB - Background Ever since the discovery of 'genes in pieces' and mRNA splicing in eukaryotes, origin and evolution of spliceosomal introns have been considered within the conceptual framework of the 'introns early' versus 'introns late' debate. The 'introns early' hypothesis, which is closely linked to the so-called exon theory of gene evolution, posits that protein-coding genes were interrupted by numerous introns even at the earliest stages of life's evolution and that introns played a major role in the origin of proteins by facilitating recombination of sequences coding for small protein/peptide modules. Under this scenario, the absence of spliceosomal introns in prokaryotes is considered to be a result of "genome streamlining". The 'introns late' hypothesis counters that spliceosomal introns emerged only in eukaryotes, and moreover, have been inserted into protein-coding genes continuously throughout the evolution of eukaryotes. Beyond the formal dilemma, the more substantial side of this debate has to do with possible roles of introns in the evolution of eukaryotes. Results I argue that several lines of evidence now suggest a coherent solution to the introns-early versus introns-late debate, and the emerging picture of intron evolution integrates aspects of both views although, formally, there seems to be no support for the original version of introns-early. Firstly, there is growing evidence that spliceosomal introns evolved from group II self-splicing introns which are present, usually, in small numbers, in many bacteria, and probably, moved into the evolving eukaryotic genome from the alpha -proteobacterial progenitor of the mitochondria. Secondly, the concept of a primordial pool of 'virus-like' genetic elements implies that self-splicing introns are among the most ancient genetic entities. Thirdly, reconstructions of the ancestral state of eukaryotic genes suggest that the last common ancestor of extant eukaryotes had an intron- rich genome. Thus, it appears that ancestors of spliceosomal introns, indeed, have existed since the earliest stages of life's evolution, in a formal agreement with the introns-early scenario. However, there is no evidence that these ancient introns ever became widespread before the emergence of eukaryotes, hence, the central tenet of introns-early, the role of introns in early evolution of proteins, has no support. However, the demonstration that numerous introns invaded eukaryotic genes at the outset of eukaryotic evolution and that subsequent intron gain has been limited in many eukaryotic lineages implicates introns as an ancestral feature of eukaryotic genomes and refutes radical versions of introns-late. Perhaps, most importantly, I argue that the intron invasion triggered other pivotal events of eukaryogenesis, including the emergence of the spliceosome, the nucleus, the linear chromosomes, the telomerase, and the ubiquitin signaling system. This concept of eukaryogenesis, in a sense, revives some tenets of the exon hypothesis, by assigning to introns crucial roles in eukaryotic evolutionary innovation. Conclusion The scenario of the origin and evolution of introns that is best compatible with the results of comparative genomics and theoretical considerations goes as follows: self- splicing introns since the earliest stages of life's evolution -- numerous spliceosomal introns invading genes of the emerging eukaryote during eukaryogenesis -- subsequent lineage-specific loss and gain of introns. The intron invasion, probably, spawned by the mitochondrial endosymbiont, might have critically contributed to the emergence of the principal features of the eukaryotic cell. This scenario combines aspects of the introns-early and introns-late views. Reviewers this article was reviewed by W. Ford Doolittle, James Darnell (nominated by W. Ford Doolittle), William Martin, and Anthony Poole. JF - Biology Direct AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1745-6150, 1745-6150 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Article No. 22 KW - Genomes KW - Endosymbionts KW - Telomerase KW - Exons KW - Mitochondria KW - mRNA KW - Recombination KW - Chromosomes KW - Splicing KW - Stem cells KW - Reviews KW - Introns KW - Spliceosomes KW - Prokaryotes KW - Evolutionary genetics KW - genomics KW - Nuclei KW - Evolution KW - Ubiquitin KW - Signal transduction KW - Radicals KW - V 22310:Genetics, Taxonomy & Structure KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=The+origin+of+introns+and+their+role+in+eukaryogenesis%3A+a+compromise+solution+to+the+introns-early+versus+introns-late+debate%3F&rft.au=Koonin%2C+Eugene+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=17456150&rft_id=info:doi/10.1186%2F1745-6150-1-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Endosymbionts; Exons; Telomerase; Mitochondria; mRNA; Recombination; Stem cells; Splicing; Chromosomes; Reviews; Introns; Spliceosomes; genomics; Evolutionary genetics; Prokaryotes; Nuclei; Evolution; Radicals; Signal transduction; Ubiquitin DO - http://dx.doi.org/10.1186/1745-6150-1-22 ER - TY - JOUR T1 - Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells AN - 19954512; 6691372 AB - We recently developed a sensitive method using biotin-N-maleimide (biotin-NM) as a probe to positively identify oxidized mitochondrial proteins. In this study, biotin-NM was used to identify oxidized cytosolic proteins in alcohol-fed mouse livers. Alcohol treatment for 6 wk elevated the levels of CYP2E1 and nitrotyrosine, a marker of oxidative stress. Markedly increased levels of oxidized proteins were detected in alcohol-fed mouse livers compared to pair-fed controls. The biotin-NM-labeled oxidized proteins from alcohol- exposed mouse livers were subsequently purified with streptavidin-agarose and resolved on 2-DE. More than 90 silver-stained protein spots that displayed differential intensities on 2-D gels were identified by MS. Peptide sequence analysis revealed that many enzymes or proteins involved in stress response, chaperone activity, intermediary metabolism, and antioxidant defense systems such as peroxiredoxin were oxidized after alcohol treatment. Smaller fragments of many proteins were repeatedly detected only in alcohol-fed mice, indicating that many oxidized proteins after alcohol exposure were degraded. Immunoblot results showed that the level of oxidized peroxiredoxin (inactivated) was markedly increased in the alcohol-exposed mouse livers and ethanol-sensitive hepatoma cells compared to the corresponding controls. Our results may explain the underlying mechanism for cellular dysfunction and increased susceptibility to other toxic agents following alcohol-mediated oxidative stress. JF - Proteomics AU - Kim, Bong-Jo AU - Hood, Brian L AU - Aragon, Richard A AU - Hardwick, James P AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Song, Byoung J AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA, bjs@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1250 EP - 1260 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 6 IS - 4 SN - 1615-9853, 1615-9853 KW - mice KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Alcoholism KW - CYP2E1 KW - Oxidative stress KW - Protein oxidation KW - Protein degradation KW - Peroxiredoxin KW - Antioxidants KW - nitrotyrosine KW - Hepatocytes KW - Probes KW - Enzymes KW - Mitochondria KW - Gels KW - Hepatoma KW - Oxidation KW - Liver KW - Protein turnover KW - Chaperones KW - proteomics KW - Ethanol KW - X 24180:Social poisons & drug abuse KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19954512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Increased+oxidation+and+degradation+of+cytosolic+proteins+in+alcohol-exposed+mouse+liver+and+hepatoma+cells&rft.au=Kim%2C+Bong-Jo%3BHood%2C+Brian+L%3BAragon%2C+Richard+A%3BHardwick%2C+James+P%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BSong%2C+Byoung+J&rft.aulast=Kim&rft.aufirst=Bong-Jo&rft.date=2006-01-01&rft.volume=6&rft.issue=4&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.200500447 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - nitrotyrosine; Antioxidants; Hepatocytes; Probes; Peroxiredoxin; Mitochondria; Enzymes; Gels; Hepatoma; Oxidative stress; Oxidation; Liver; Protein turnover; Chaperones; proteomics; Ethanol DO - http://dx.doi.org/10.1002/pmic.200500447 ER - TY - JOUR T1 - TRICOM Vector Based Cancer Vaccines AN - 19887424; 7653801 AB - For the immune system to mount an effective antitumor T-cell response, an adequate number of T-cells specific for the antigens expressed by the malignancy must be activated [1]. Since most antigens expressed by tumors are "self"- antigens, tumor antigens often lack endogenous immunogenicity and thus do not sufficiently activate T-cells to levels that can mediate tumor eradication. In addition, virtually all solid tumor cells lack the costimulatory molecules necessary to activate tumor-specific T-cells. Approaches that stimulate immune responses to these tumor antigens have the potential to alter this poor responsiveness. This theory has promoted the use of active immunotherapy to generate immune responses against tumor- associated antigens (TAAs) for the treatment of cancer. As one such vaccine strategy, we have utilized poxviruses as delivery vehicles for TAAs in combination with T-cell costimulatory molecules. Initial studies have demonstrated that the insertion of costimulatory molecule trangenes into viral vectors, along with a TAA transgene, greatly enhances the immune response to the antigen. Using this approach, a TRIad of COstimulatory Molecules (TRICOM; B7-1, ICAM-1 and LFA-3) has been shown to enhance T-cell responses to TAAs to levels far greater than any one or two of the costimulatory molecules in combination. In this article, preclinical findings and recent clinical applications of TRICOMbased vaccines as a cancer immunotherapy are reviewed. JF - Current Pharmaceutical Design AU - Garnett, Charlie T AU - Greiner, John W AU - Tsang, Kwong-Yok AU - Kudo-Saito, Chie AU - Grosenbach, Douglas W AU - Chakraborty, Mala AU - Gulley, James L AU - Arlen, Philip M AU - Schlom, Jeffrey AU - Hodge, James W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 8B09, MSC 1750, Bethesda, MD 20892-1750, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 351 EP - 361 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 12 IS - 3 SN - 1381-6128, 1381-6128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - TRICOM KW - costimulation KW - vaccination KW - TAA KW - cancer immunotherapy KW - Cancer vaccines KW - Solid tumors KW - Immunotherapy KW - CD58 antigen KW - Therapeutic applications KW - Tumors KW - B7-1 antigen KW - Costimulator KW - Malignancy KW - Insertion KW - Immunogenicity KW - Reviews KW - Antigen (tumor-associated) KW - intercellular adhesion molecule 1 KW - Lymphocytes T KW - Immune response KW - Antitumor activity KW - V 22350:Immunology KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Pharmaceutical+Design&rft.atitle=TRICOM+Vector+Based+Cancer+Vaccines&rft.au=Garnett%2C+Charlie+T%3BGreiner%2C+John+W%3BTsang%2C+Kwong-Yok%3BKudo-Saito%2C+Chie%3BGrosenbach%2C+Douglas+W%3BChakraborty%2C+Mala%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Garnett&rft.aufirst=Charlie&rft.date=2006-01-01&rft.volume=12&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Current+Pharmaceutical+Design&rft.issn=13816128&rft_id=info:doi/10.2174%2F138161206775201929 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Solid tumors; Immunotherapy; CD58 antigen; Therapeutic applications; Tumors; Costimulator; B7-1 antigen; Malignancy; Immunogenicity; Insertion; Reviews; intercellular adhesion molecule 1; Antigen (tumor-associated); Lymphocytes T; Immune response; Antitumor activity DO - http://dx.doi.org/10.2174/138161206775201929 ER - TY - JOUR T1 - On the origin of cells and viruses: A comparative-genomic perspective AN - 19876973; 7828731 AB - It is proposed that the pre-cellular stage of biological evolution, including the Last Universal Common Ancestor (LUCA) of modern cellular life forms, occurred within networks of inorganic compartments that hosted a diverse mix of virus-like genetic elements. This viral model of cellular origin recapitulates the early ideas of J.B.S. Haldane, sketched in his 1928 essay on the origin of life. However, unlike in Haldane's day, there is substantial empirical support for this scenario from three major lines of evidence provided by comparative genomics: (i) the lack of homology among the core components of the DNA replication systems between the two primary lines of descent of cellular life forms, archaea and bacteria, (ii) the similar lack of homology between the enzymes of lipid biosynthesis in conjunction with distinct membrane chemistries in archaea and bacteria, and (iii) the spread of several viral hallmark genes, which encode proteins with key functions in viral replication and morphogenesis, among numerous and extremely diverse groups of viruses, in contrast to their absence in cellular life forms. Under the viral model of pre-cellular evolution, the key elements of cells including the replication apparatus, membranes, molecular complexes involved in membrane transport and translocation, and others originated as components of virus-like entities. This model alleviates, at least in part, the challenge of the emergence of the immensely complex organization of modern cells. JF - Israel Journal of Ecology and Evolution AU - Koonin, E V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA, koonin@ncbi.nlm.nih.go Y1 - 2006 PY - 2006 DA - 2006 SP - 299 EP - 318 VL - 52 IS - 3-4 SN - 1565-8187, 1565-8187 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts; Ecology Abstracts KW - Molecular modelling KW - DNA biosynthesis KW - Archaea KW - Homology KW - Replication KW - Lipids KW - Morphogenesis KW - Enzymes KW - genomics KW - Translocation KW - Evolution KW - D 04040:Ecosystem and Ecology Studies KW - V 22320:Replication KW - G 07770:Bacteria KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Israel+Journal+of+Ecology+and+Evolution&rft.atitle=On+the+origin+of+cells+and+viruses%3A+A+comparative-genomic+perspective&rft.au=Koonin%2C+E+V&rft.aulast=Koonin&rft.aufirst=E&rft.date=2006-01-01&rft.volume=52&rft.issue=3-4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Israel+Journal+of+Ecology+and+Evolution&rft.issn=15658187&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Molecular modelling; Homology; Replication; Lipids; Morphogenesis; Enzymes; genomics; Translocation; Evolution; Archaea ER - TY - JOUR T1 - Genome increase as a clock for the origin and evolution of life AN - 19857031; 7154605 AB - Background The size of non-redundant functional genome can be an indicator of biological complexity of living organisms. Several positive feedback mechanisms including gene cooperation and duplication with subsequent specialization may result in the exponential growth of biological complexity in macro-evolution. Results I propose a hypothesis that biological complexity increased exponentially during evolution. Regression of the logarithm of functional non-redundant genome size versus time of origin in major groups of organisms showed a 7.8-fold increase per 1 billion years, and hence the increase of complexity can be viewed as a clock of macro-evolution. A strong version of the exponential hypothesis is that the rate of complexity increase in early (pre-prokaryotic) evolution of life was at most the same (or even slower) than observed in the evolution of prokaryotes and eukaryotes. Conclusion The increase of functional non-redundant genome size in macro-evolution was consistent with the exponential hypothesis. If the strong exponential hypothesis is true, then the origin of life should be dated 10 billion years ago. Thus, the possibility of panspermia as a source of life on earth should be discussed on equal basis with alternative hypotheses of de-novo life origin. Panspermia may be proven if bacteria similar to terrestrial ones are found on other planets or satellites in the solar system. Reviewers This article was reviewed by Eugene V. Koonin, Chris Adami and Arcady Mushegian. JF - Biology Direct AU - Sharov, Alexei A AD - Laboratory of Genetics, National Institute on Aging (NIA/NIH), 333 Cassell Dr., Baltimore, MD 21224, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1745-6150, 1745-6150 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Article No. 17 KW - Genomes KW - Reviews KW - Specialization KW - Feedback KW - Eugenes KW - Prokaryotes KW - Satellites KW - Evolution KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19857031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=Genome+increase+as+a+clock+for+the+origin+and+evolution+of+life&rft.au=Sharov%2C+Alexei+A&rft.aulast=Sharov&rft.aufirst=Alexei&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=17456150&rft_id=info:doi/10.1186%2F1745-6150-1-17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Reviews; Specialization; Feedback; Prokaryotes; Satellites; Evolution; Eugenes DO - http://dx.doi.org/10.1186/1745-6150-1-17 ER - TY - JOUR T1 - PPAR gamma insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor- Kappa B signaling pathway AN - 19849943; 6943542 AB - The molecular genetic events underlying thyroid carcinogenesis are poorly understood. Mice harboring a knock-in dominantly negative mutant thyroid hormone receptor beta (TR beta super(PV/PV) mouse) spontaneously develop follicular thyroid carcinoma similar to human thyroid cancer. Using this mutant mouse, we tested the hypothesis that the peroxisome proliferator-activated receptor gamma (PPAR gamma ) could function as a tumor suppressor in thyroid cancer in vivo. Using the offspring from the cross of TR beta super(PV/+) and PPAR gamma super(+/-) mice, we found that thyroid carcinogenesis progressed significantly faster in TR beta super(PV/PV) mice with PPAR gamma insufficiency from increased cell proliferation and reduced apoptosis. Reduced PPAR gamma protein abundance led to the activation of the nuclear factor- Kappa B signaling pathway, resulting in the activation of cyclin D1 and repression of critical genes involved in apoptosis. Treatment of TR beta super(PV/PV) mice with a PPAR gamma agonist, rosiglitazone, delayed the progression of thyroid carcinogenesis by decreasing cell proliferation and activation of apoptosis. These results suggest that PPAR gamma is a critical modifier in thyroid carcinogenesis and could be tested as a therapeutic target in thyroid follicular carcinoma. JF - Oncogene AU - Kato, Y AU - Ying, H AU - Zhao, L AU - Furuya, F AU - Araki, O AU - Willingham, M C AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, chengs@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 2736 EP - 2747 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 25 IS - 19 SN - 0950-9232, 0950-9232 KW - Toxicology Abstracts; Genetics Abstracts; Oncogenes & Growth Factors Abstracts KW - thyroid cancer KW - mutant thyroid hormone receptor KW - PPAR[italic gamma] KW - NF-[kappa]B KW - mouse model KW - apoptosis KW - Tumor suppressor genes KW - Apoptosis KW - Peroxisome proliferator-activated receptors KW - thyroid carcinoma KW - rosiglitazone KW - NF- Kappa B protein KW - Cell activation KW - Thyroid hormone receptors KW - Carcinogenesis KW - Cell proliferation KW - Genetic crosses KW - cyclin D1 KW - Gene silencing KW - Signal transduction KW - X 24490:Other KW - G 07730:Development & Cell Cycle KW - B 26416:Other tumor suppressor genes/antioncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19849943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=PPAR+gamma+insufficiency+promotes+follicular+thyroid+carcinogenesis+via+activation+of+the+nuclear+factor-+Kappa+B+signaling+pathway&rft.au=Kato%2C+Y%3BYing%2C+H%3BZhao%2C+L%3BFuruya%2C+F%3BAraki%2C+O%3BWillingham%2C+M+C%3BCheng%2C+S-Y&rft.aulast=Kato&rft.aufirst=Y&rft.date=2006-01-01&rft.volume=25&rft.issue=19&rft.spage=2736&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Apoptosis; Peroxisome proliferator-activated receptors; thyroid carcinoma; rosiglitazone; Cell activation; NF- Kappa B protein; Thyroid hormone receptors; Carcinogenesis; thyroid cancer; Cell proliferation; Genetic crosses; Signal transduction; Gene silencing; cyclin D1 DO - http://dx.doi.org/10.1038/sj.onc.1209299 ER - TY - JOUR T1 - Interferon-[gamma] induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors AN - 19849206; 6955643 AB - We have developed an epithelial cell carcinoma model for studying efficacy of IFN[gamma] gene therapy and have identified components of IFN[gamma]- signaling pathway responsible for its direct anti-tumor actions. The tumor results from ectopic expression of SV40 Large T-Antigen (SV40 T-Ag) oncogene in lens of transgenic mouse ([alpha]T3) and complete regression of the tumor is induced by targeting expression of IFN[gamma] into malignant lens cells. Inflammatory cells are absent in lens of [alpha]T3 or DT (co-expressing IFN[gamma] and SV40-T-Antigen) mice and the transformed lens cells are non- immunogenic, suggesting non-involvement of immunologic cells. We show that IFN[gamma] has direct growth-inhibitory effects on tumor cells, induces death of tumor cells by apoptosis and that these effects are mediated by two transcription factors, IRF-1 (interferon-regulatory factor-1) and ICSBP (interferon-consensus sequence-binding protein) induced by IFN[gamma]. Furthermore, stable transfection with ICSBP or IRF-1 construct inhibits lens carcinoma cell growth by upregulating Caspase-1, p21 super(WAF1) and p27 expression. In contrast, tumor progression in [alpha]T3 lens correlates with inhibition of IRF-1 and ICSBP expression. Our results suggest that IFN[gamma] gene therapy maybe effective in malignant diseases for which DNA tumor viruses are etiologic agents and that antitumor actions of IRF-1/ICSBP can be exploited therapeutically to circumvent adverse clinical effects associated with IFN therapy. JF - Oncogene AU - Egwuagu, C E AU - Li, W AU - Yu, C-R AU - Lin, M Che Mei AU - Chan, C-C AU - Nakamura, T AU - Chepelinsky, A B AD - Laboratories of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA, egwuaguc@nei.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3670 EP - 3679 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 25 IS - 26 SN - 0950-9232, 0950-9232 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - IFN[gamma] KW - epithelial cell carcinoma KW - SV40 T-Antigen KW - IRF-1 KW - ICSBP KW - apoptosis KW - Epithelial cells KW - gamma -Interferon KW - Apoptosis KW - Animal models KW - Cell culture KW - Tumor cells KW - Oncogenes KW - cyclin-dependent kinase inhibitor p21 KW - Simian virus 40 KW - Gene therapy KW - DNA tumor viruses KW - Tumors KW - Transgenic mice KW - Carcinoma KW - Inflammation KW - ICSBP protein KW - Interferon KW - Transfection KW - Immunogenicity KW - Transcription factors KW - Interferon regulatory factor 1 KW - Caspase-1 KW - Cyclin-dependent kinase inhibitor p21 KW - Signal transduction KW - V 22350:Immunology KW - B 26320:Other oncogenes KW - F 06915:Cancer Immunology KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19849206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Interferon-%5Bgamma%5D+induces+regression+of+epithelial+cell+carcinoma%3A+critical+roles+of+IRF-1+and+ICSBP+transcription+factors&rft.au=Egwuagu%2C+C+E%3BLi%2C+W%3BYu%2C+C-R%3BLin%2C+M+Che+Mei%3BChan%2C+C-C%3BNakamura%2C+T%3BChepelinsky%2C+A+B&rft.aulast=Egwuagu&rft.aufirst=C&rft.date=2006-01-01&rft.volume=25&rft.issue=26&rft.spage=3670&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209402 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Epithelial cells; Apoptosis; Gene therapy; DNA tumor viruses; Animal models; Cell culture; Tumors; Transgenic mice; Tumor cells; Inflammation; Carcinoma; ICSBP protein; Interferon; Oncogenes; cyclin-dependent kinase inhibitor p21; Immunogenicity; Transfection; Transcription factors; Interferon regulatory factor 1; Caspase-1; Cyclin-dependent kinase inhibitor p21; Signal transduction; Simian virus 40 DO - http://dx.doi.org/10.1038/sj.onc.1209402 ER - TY - JOUR T1 - Transcriptome coexpression map of human embryonic stem cells AN - 19844174; 7078171 AB - Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic analysis has yet addressed whether gene expression in human ES cells may be regulated in chromosomal domains, and no chromosomal domains of coexpression have been identified. We report the first transcriptome coexpression map of the human ES cell and the earliest stage of ES differentiation, the embryoid body (EB), for the analysis of how transcriptional regulation interacts with genomic structure during ES self-renewal and differentiation. We determined the gene expression profiles from multiple ES and EB samples and identified chromosomal domains showing coexpression of adjacent genes on the genome. The coexpression domains were not random, with significant enrichment in chromosomes 8, 11, 16, 17, 19, and Y in the ES state, and 6, 11, 17, 19 and 20 in the EB state. The domains were significantly associated with Giemsa-negative bands in EB, yet showed little correlation with known cytogenetic structures in ES cells. Different patterns of coexpression were revealed by comparative transcriptome mapping between ES and EB. The findings and methods reported in this investigation advance our understanding of how genome organization affects gene expression in human ES cells and help to identify new mechanisms and pathways controlling ES self- renewal or differentiation. JF - BMC Genomics AU - Li, Huai AU - Liu, Ying AU - Shin, Soojung AU - Sun, Yu AU - Loring, Jeanne F AU - Mattson, Mark P AU - Rao, Mahendra S AU - Zhan1, Ming AD - Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD 21224, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2164, 1471-2164 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Article No. 103 KW - Gene expression KW - Differentiation KW - chromosome 8 KW - Stem cells KW - Embryo cells KW - Gene regulation KW - Transcription KW - genomics KW - Gene mapping KW - G 07880:Human Genetics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genomics&rft.atitle=Transcriptome+coexpression+map+of+human+embryonic+stem+cells&rft.au=Li%2C+Huai%3BLiu%2C+Ying%3BShin%2C+Soojung%3BSun%2C+Yu%3BLoring%2C+Jeanne+F%3BMattson%2C+Mark+P%3BRao%2C+Mahendra+S%3BZhan1%2C+Ming&rft.aulast=Li&rft.aufirst=Huai&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Genomics&rft.issn=14712164&rft_id=info:doi/10.1186%2F1471-2164-7-103 L2 - http://www.biomedcentral.com/1471-2164/7/103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; chromosome 8; Differentiation; Stem cells; Embryo cells; Gene regulation; Transcription; genomics; Gene mapping DO - http://dx.doi.org/10.1186/1471-2164-7-103 ER - TY - JOUR T1 - Mechanisms Controlling Embryonic Stem Cell Self-Renewal and Differentiation AN - 19842802; 7259655 AB - Embryonic stem (ES) cells are pluripotent cells with indefinite replication potential and ability to differentiate into all types of cells. An understanding of the regulatory mechanisms responsible for pluripotency in ES cells is critical for realizing their potential in regenerative medicine and science. Cross-species studies on ES cells have identified pathways and networks that are either fundamental to or species-specific for self-renewal and differentiation. Although pluripotency as an essential function in multicellular organisms is conserved through evolution, mechanisms primed for differentiation contribute substantially to the differences among stem cells derived from different tissues or species. Transcriptome mapping analysis has determined the chromosomal domains of gene coexpression patterns specific to the ES state and demonstrated that regulation of ES cell development is operative at both the local chromosomal domain level and global level. Combinatorial signals from multiple pathways regulate the expression of key intrinsic factors critical for ES cell fate determination. The regulatory core formed by Oct4, Sox2, and Nanog, in particular, activates genes critical for self-renewal and represses genes initiating differentiation, controlling ES cell pluripotency. Here, we review recent findings on mechanisms controlling ES cell development. By integrating data from different sources, we present a global picture of how ES cells reach the decision of self-renewal or differentiation. JF - Critical Reviews in Eukaryotic Gene Expression AU - Sun, Y AU - Li, H AU - Yang, H AU - Rao AU - Zhan, M AD - National Institute on Aging, NIH, 333 Cassall Drive, Baltimore, MD 21224, USA, zhanmi@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 211 EP - 231 VL - 16 IS - 3 SN - 1045-4403, 1045-4403 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Data processing KW - Replication KW - Gene expression KW - Differentiation KW - Stem cells KW - Embryo cells KW - Reviews KW - Regeneration KW - Cell fate KW - Oct-4 protein KW - Evolution KW - Gene mapping KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19842802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Eukaryotic+Gene+Expression&rft.atitle=Mechanisms+Controlling+Embryonic+Stem+Cell+Self-Renewal+and+Differentiation&rft.au=Sun%2C+Y%3BLi%2C+H%3BYang%2C+H%3BRao%3BZhan%2C+M&rft.aulast=Sun&rft.aufirst=Y&rft.date=2006-01-01&rft.volume=16&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Eukaryotic+Gene+Expression&rft.issn=10454403&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Differentiation; Stem cells; Data processing; Embryo cells; Replication; Reviews; Regeneration; Cell fate; Oct-4 protein; Evolution; Gene mapping ER - TY - JOUR T1 - Preclinical and phase I clinical trial of blockade of IL-15 using Mik beta 1 monoclonal antibody in T cell large granular lymphocyte leukemia AN - 19840043; 6662565 AB - Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia were treated in a phase I dose-escalation trial with the murine monoclonal antibody Mik beta 1. Mik beta 1 identifies CD122, the beta -subunit shared by the IL-2 and IL-15 receptors. At the doses administered in this study the antibody inhibited the actions of IL-15 on both natural killer and T cells and that of IL-2 when the intermediate-affinity IL-2 receptor was expressed. Mik beta 1 treatment was not associated with significant toxicity or with the development of an immune response to the infused monoclonal antibody. At these doses of Mik beta 1, >95% saturation of the IL-2/IL-15 beta receptor (CD122) on the surfaces of the leukemic cells was achieved. Furthermore, in seven patients this led to the down-modulation of the receptor from the surfaces of the leukemic cells. Nevertheless, no patients manifested a reduction in peripheral leukemic cell count or an amelioration of their hematocytopenia. This latter observation may reflect the fact that the monoclonal T cell large granular lymphocyte leukemia leukemic cells of the patients did not produce IL-2 or IL-15 or require their actions for cell survival. In light of the lack of toxicity and lack of immunogenicity of the antibody observed in the present study and the role for IL-15 in the pathogenesis of autoimmune diseases, clinical trials should be performed using the humanized version of Mik beta 1 in groups of patients with human T cell lymphotropic virus I-associated myelopathy/tropical spastic paraparesis, rheumatoid arthritis, multiple sclerosis and refractory celiac disease. JF - Proceedings of the National Academy of Sciences, USA AU - Morris, John C AU - Janik, John E AU - White, Jeffrey D AU - Fleisher, Thomas A AU - Brown, Margaret AU - Tsudo, Mitsuru AU - Goldman, Carolyn K AU - Bryant, Bonita AU - Petrus, Michael AU - Top, Lois AU - Lee, Cathryn C AU - Gao, Wendy AU - Waldmann, Thomas A AD - Metabolism Branch, Center for Cancer Research, and Office of Cancer Complementary and Alternative Medicine, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 401 EP - 406 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 2 SN - 0027-8424, 0027-8424 KW - Toxicology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Cell survival KW - Interleukin 15 receptors KW - Interleukin 2 KW - Spinal cord KW - Multiple sclerosis KW - Monoclonal antibodies KW - Autoimmune diseases KW - Celiac disease KW - Natural killer cells KW - Toxicity KW - Clinical trials KW - Interleukin 2 receptors KW - Leukemia KW - Rheumatoid arthritis KW - Interleukin 15 KW - CD122 antigen KW - Immunogenicity KW - Tropical spastic paraparesis KW - Central nervous system diseases KW - Lymphocytes T KW - X 24310:Pharmaceuticals KW - V 22350:Immunology KW - F 06150:Immunotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19840043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Preclinical+and+phase+I+clinical+trial+of+blockade+of+IL-15+using+Mik+beta+1+monoclonal+antibody+in+T+cell+large+granular+lymphocyte+leukemia&rft.au=Morris%2C+John+C%3BJanik%2C+John+E%3BWhite%2C+Jeffrey+D%3BFleisher%2C+Thomas+A%3BBrown%2C+Margaret%3BTsudo%2C+Mitsuru%3BGoldman%2C+Carolyn+K%3BBryant%2C+Bonita%3BPetrus%2C+Michael%3BTop%2C+Lois%3BLee%2C+Cathryn+C%3BGao%2C+Wendy%3BWaldmann%2C+Thomas+A&rft.aulast=Morris&rft.aufirst=John&rft.date=2006-01-01&rft.volume=103&rft.issue=2&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Interleukin 15 receptors; Interleukin 2; Monoclonal antibodies; Multiple sclerosis; Spinal cord; Celiac disease; Autoimmune diseases; Natural killer cells; Toxicity; Clinical trials; Interleukin 2 receptors; Leukemia; Rheumatoid arthritis; Interleukin 15; Immunogenicity; CD122 antigen; Tropical spastic paraparesis; Central nervous system diseases; Lymphocytes T ER - TY - JOUR T1 - Combined prophylactic and therapeutic cancer vaccine: Enhancing CTL responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice AN - 19827127; 6736168 AB - We identified the strategies to induce a CTL response to human papillomavirus (HPV) 16 E2 in HLA-A2 transgenic mice (AAD). A chimeric HPV16 virus-like particle (VLP) that includes full length HPV16 E7 and E2 (VLP-E7E2) was generated. The combination of E2 and E7 has the advantage that E2 is expressed in early dysplasia and neoplasia lesions, where E7 is expressed in more advance lesions. Since T cell response to E2 is less defined, we first evaluated the strategies to enhancing CD8 super(+) T cell responses to HPV E7, using different combinations of immune-modulators with VLP-E7E2. Data showed that the CTL response to E7 could be significantly enhanced by coinjection of GM-CSF and antiCD40 antibodies with chimeric VLP-E7E2 without adjuvant. However, using the same combination, a low level of CD8 super(+) T cell response to E2 was detected. To enhance the CD8+ T cell response to E2, we analyzed T cell epitopes from E2 sequence. A heterogonous prime-boost with chimeric VLP-E7E2 and E2 peptides was performed. The data showed that the priming with chimeric VLP-E7E2, followed by boosting with E2 peptides, gave a better CTL response than 2 immunizations with E2 peptides. The enhanced immunity is due to the increase of CD11c super(+) and CD11c super(+) CD40 super(+) double positive dendritic cells in mice that received immune-modulators, GM-CSF and antiCD40. Furthermore, the level of anti-L1 antibodies remains similar in mice immunized with chimeric VLP with/without immune-modulators. Thus, the data suggested that the chimeric VLP-E7E2 has a therapeutic potential for the treatment of HPV-associated CINs and cancer without diminishing VLPs potential as a prophylactic vaccine by inducing anti-L1 antibodies against free virus. JF - International Journal of Cancer AU - Qian, Jiahua AU - Dong, Yujun AU - Pang, Yuk-Ying S AU - Ibrahim, Ramy AU - Berzofsky, Jay A AU - Schiller, John T AU - Khleif, Samir N AD - Vaccine Branch, NCI, National Naval Medical Center, Bldg 8, Bethesda, MD, qianj@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3022 EP - 3029 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - vaccine HPV 16 CTL chimeric VLP HPV 16 E2 dendritic cells KW - Histocompatibility antigen HLA KW - Cancer vaccines KW - Virus-like particles KW - Data processing KW - Dysplasia KW - Granulocyte-macrophage colony-stimulating factor KW - Adjuvants KW - CD8 antigen KW - Transgenic mice KW - Immunomodulation KW - Cancer KW - CD11c antigen KW - Neoplasia KW - Immunization KW - Dendritic cells KW - Antibodies KW - Cytotoxicity KW - Human papillomavirus 16 KW - Lymphocytes T KW - Vaccines KW - Epitopes KW - V 22350:Immunology KW - W3 33350:Cancer vaccines KW - F 06150:Immunotherapy KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19827127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Combined+prophylactic+and+therapeutic+cancer+vaccine%3A+Enhancing+CTL+responses+to+HPV16+E2+using+a+chimeric+VLP+in+HLA-A2+mice&rft.au=Qian%2C+Jiahua%3BDong%2C+Yujun%3BPang%2C+Yuk-Ying+S%3BIbrahim%2C+Ramy%3BBerzofsky%2C+Jay+A%3BSchiller%2C+John+T%3BKhleif%2C+Samir+N&rft.aulast=Qian&rft.aufirst=Jiahua&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3022&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21781 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Cancer vaccines; Data processing; Virus-like particles; Dysplasia; Granulocyte-macrophage colony-stimulating factor; CD8 antigen; Adjuvants; Transgenic mice; Immunomodulation; Immunization; Neoplasia; CD11c antigen; Cancer; Dendritic cells; Cytotoxicity; Antibodies; Lymphocytes T; Vaccines; Epitopes; Human papillomavirus 16 DO - http://dx.doi.org/10.1002/ijc.21781 ER - TY - JOUR T1 - T-Lymphocyte Profiles in FIV-Infected Wild Lions and Pumas Reveal Cd4 Depletion AN - 19779835; 7313178 AB - Feline immunodeficiency virus (FIV) is a lentivirus related to human immunodeficiency virus (HIV) that causes feline AIDS in the domestic cat (Felis catus). Serological surveys indicate that at least 25 other species of cat possess antibodies that cross-react with domestic cat FIV. Most infected nondomestic cat species are without major symptoms of disease. Long-term studies of FIV genome variation and pathogenesis reveal patterns consistent with coadaptation of virus and host in free-ranging FIV-Ple-infected African lions (Panthera leo) and FIV-Pco-infected pumas (Puma concolor) populations. This report examined correlates of immunodeficiency in wild and captive lions and pumas by quantifying CD5+, CD4+, and CD8+ T-cell subsets. Free-ranging FIV- Ple-infected lions had immunofluorescence flow cytometry (IFC) profiles marked by a dramatic decline in CD4+ subsets, a reduction of the CD4+/CD8+ ratio, reduction of CD8+ beta super(high) cells, and expansion of the CD8+ beta super(low) subset relative to uninfected lions. An overall significant depletion in CD5+ T-cells in seropositive lions was linked with a compensatory increase in total CD5- lymphocytes. The IFC profiles were altered significantly in 50% of the seropositive individuals examined. The FIV-Pco-infected pumas had a more generalized response of lymphopenia expressed as a significant decline in total lymphocytes, CD5+ T-cells, and CD5- lymphocytes as well as a significant reduction in CD4+ T-cells. Like lions, seropositive pumas had a significant decline in CD8+ beta super(high) cells but differed by not having compensatory expansion of CD8+ beta super(low) cells relative to controls. Results from FIV-infected lions and pumas parallel human and Asian monkey CD4+ diminution in HIV and SIV infection, respectively, and suggest there may be unrecognized immunological consequences of FIV infection in these two species of large cats. JF - Journal of Wildlife Diseases AU - Roelke, ME AU - Pecon-Slattery, J AU - Taylor, S AU - Citino, S AU - Brown, E AU - Packer, C AU - VandeWoude, S AU - O'Brien, S J AD - Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 234 EP - 248 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 42 IS - 2 SN - 0090-3558, 0090-3558 KW - House cat KW - domestic cat KW - Ecology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Genomes KW - Acquired immune deficiency syndrome KW - Coadaptation KW - Feline immunodeficiency virus KW - Wildlife KW - Lymphopenia KW - Immunodeficiency KW - Immunofluorescence KW - CD8 antigen KW - Infection KW - Serological surveys KW - Flow cytometry KW - Antibodies KW - CD4 antigen KW - Lentivirus KW - Felis catus KW - Human immunodeficiency virus KW - Lymphocytes T KW - Panthera leo KW - Simian immunodeficiency virus KW - V 22360:AIDS and HIV KW - D 04040:Ecosystem and Ecology Studies KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19779835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Diseases&rft.atitle=T-Lymphocyte+Profiles+in+FIV-Infected+Wild+Lions+and+Pumas+Reveal+Cd4+Depletion&rft.au=Roelke%2C+ME%3BPecon-Slattery%2C+J%3BTaylor%2C+S%3BCitino%2C+S%3BBrown%2C+E%3BPacker%2C+C%3BVandeWoude%2C+S%3BO%27Brien%2C+S+J&rft.aulast=Roelke&rft.aufirst=ME&rft.date=2006-01-01&rft.volume=42&rft.issue=2&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Diseases&rft.issn=00903558&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Coadaptation; Acquired immune deficiency syndrome; Wildlife; Immunodeficiency; Lymphopenia; CD8 antigen; Immunofluorescence; Infection; Flow cytometry; Serological surveys; CD4 antigen; Antibodies; Lymphocytes T; Lentivirus; Human immunodeficiency virus; Felis catus; Feline immunodeficiency virus; Panthera leo; Simian immunodeficiency virus ER - TY - JOUR T1 - Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance AN - 19777516; 6955641 AB - Ultraviolet A (UVA, 315-400 nm), constituting about 95% of ultraviolet irradiation in natural sunlight, represents a major environmental challenge to the skin and is clearly associated with human skin cancer. It has proven difficult to show direct actions of UVA as a carcinogen in human cells. Here, we demonstrate that chronic UVA exposures at environmentally relevant doses in vitro can induce malignant transformation of human keratinocytes associated with acquired apoptotic resistance. As evidence of carcinogenic transformation, UVA-long-treated (24 J/cm super(2) once/week for 18 weeks) HaCaT (ULTH) cells showed increased secretion of matrix metalloproteinase (MMP-9), overexpression of keratin 13, altered morphology and anchorage-independent growth. Malignant transformation was established by the production of aggressive squamous cell carcinomas after inoculation of ULTH cells into nude mice (NC sub(r)-nu). ULTH cells were resistant to apoptosis induced not only by UVA but also by UVB and arsenite, two other human skin carcinogens. ULTH cells also became resistant to apoptosis induced by etoposide, staurosporine and doxorubicin hydrochloride. Elevated phosphorylation of protein kinase B (PKB, also called AKT) and reduced expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) were detected in ULTH cells. The resistance of ULTH cells to UVA-induced apoptosis was reversed by either inhibition of phosphatidylinositol 3-kinase (PI-3K) or adenovirus expression of PTEN or dominant negative AKT. These data indicate that UVA has carcinogenic potential in human keratinocytes and that the increased AKT signaling and decreased PTEN expression may contribute to this malignant transformation. Further comparisons between the transformed ULTH and control cells should lead to a better understanding of the mechanism of UVA carcinogenesis and may help identify biomarkers for UVA-induced skin malignancies. JF - Oncogene AU - He, Y-Y AU - Pi, J AU - Huang, J-L AU - Diwan, BA AU - Waalkes, M P AU - Chignell, C F AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, he3@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3680 EP - 3688 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 25 IS - 26 SN - 0950-9232, 0950-9232 KW - Virology & AIDS Abstracts; Genetics Abstracts; Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - UVA KW - transformation KW - carcinogenesis KW - AKT KW - keratinocyte KW - PTEN KW - Transformation KW - Apoptosis KW - Secretion KW - Skin cancer KW - Matrix metalloproteinase KW - PTEN protein KW - Carcinogens KW - 1-Phosphatidylinositol 3-kinase KW - Malignancy KW - U.V. radiation KW - Phosphorylation KW - Radiation KW - Staurosporine KW - AKT protein KW - Sunlight KW - Keratinocytes KW - Etoposide KW - Data processing KW - Adenovirus KW - Arsenite KW - squamous cell carcinoma KW - biomarkers KW - Doxorubicin KW - Keratin KW - Carcinogenesis KW - Inoculation KW - Gelatinase B KW - Signal transduction KW - X 24210:Radiation & radioactive materials KW - B 26170:Other oncogenes & GF's with serine-threonine kinase activity KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19777516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Chronic+UVA+irradiation+of+human+HaCaT+keratinocytes+induces+malignant+transformation+associated+with+acquired+apoptotic+resistance&rft.au=He%2C+Y-Y%3BPi%2C+J%3BHuang%2C+J-L%3BDiwan%2C+BA%3BWaalkes%2C+M+P%3BChignell%2C+C+F&rft.aulast=He&rft.aufirst=Y-Y&rft.date=2006-01-01&rft.volume=25&rft.issue=26&rft.spage=3680&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209384 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Apoptosis; Secretion; Matrix metalloproteinase; Skin cancer; Carcinogens; PTEN protein; Malignancy; 1-Phosphatidylinositol 3-kinase; U.V. radiation; Radiation; Phosphorylation; Staurosporine; AKT protein; Sunlight; Keratinocytes; Etoposide; Data processing; Arsenite; squamous cell carcinoma; biomarkers; Doxorubicin; Keratin; Carcinogenesis; Inoculation; Gelatinase B; Signal transduction; Adenovirus DO - http://dx.doi.org/10.1038/sj.onc.1209384 ER - TY - JOUR T1 - Intra-arterial adenoviral mediated tumor transfection in a novel model of cancer gene therapy AN - 19775899; 7155467 AB - Background The aim of the present study was to develop and characterize a novel in vivo cancer gene therapy model in which intra-arterial adenoviral gene delivery can be characterized. In this model, the rat cremaster muscle serves as the site for tumor growth and provides convenient and isolated access to the tumor parenchyma with discrete control of arterial and venous access for delivery of agents. Results Utilizing adenovirus encoding the green fluorescent protein we demonstrated broad tumor transfection. We also observed a dose dependant increment in luciferase activity at the tumor site using an adenovirus encoding the luciferase reporter gene. Finally, we tested the intra-arterial adenovirus dwelling time required to achieve optimal tumor transfection and observed a minimum time of 30 minutes. Conclusion We conclude that adenovirus mediated tumor transfection grown in the cremaster muscle of athymic nude rats via an intra-arterial route could be achieved. This model allows definition of the variables that affect intra-arterial tumor transfection. This particular study suggests that allowing a defined intra-tumor dwelling time by controlling the blood flow of the affected organ during vector infusion can optimize intra- arterial adenoviral delivery. JF - Molecular Cancer AU - Cabrera, Gustavo AU - Porvasnik, Stacy L AU - DiCorleto, Paul E AU - Siemionow, Maria AU - Goldman, Corey K AD - Gene Therapy Laboratory, National Cancer Institute, Mexico City, Mexico Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 5 SN - 1476-4598, 1476-4598 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 32 KW - Parenchyma KW - Gene therapy KW - Adenovirus KW - Animal models KW - Muscles KW - Green fluorescent protein KW - Tumors KW - Cancer KW - Models KW - Expression vectors KW - Transfection KW - Gene transfer KW - Reporter gene KW - W 30915:Pharmaceuticals & Vaccines KW - G 07870:Mammals KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19775899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer&rft.atitle=Intra-arterial+adenoviral+mediated+tumor+transfection+in+a+novel+model+of+cancer+gene+therapy&rft.au=Cabrera%2C+Gustavo%3BPorvasnik%2C+Stacy+L%3BDiCorleto%2C+Paul+E%3BSiemionow%2C+Maria%3BGoldman%2C+Corey+K&rft.aulast=Cabrera&rft.aufirst=Gustavo&rft.date=2006-01-01&rft.volume=5&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer&rft.issn=14764598&rft_id=info:doi/10.1186%2F1476-4598-5-32 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Expression vectors; Parenchyma; Gene therapy; Reporter gene; Gene transfer; Transfection; Green fluorescent protein; Muscles; Animal models; Tumors; Cancer; Models; Adenovirus DO - http://dx.doi.org/10.1186/1476-4598-5-32 ER - TY - JOUR T1 - Multimodal imaging of the sonic organ of Porichthys notatus, the singing midshipman fish AN - 19774087; 6729355 AB - The sonic midshipman fish, Porichthys notatus, is a bottom-dwelling species whose swim bladder has evolved into a highly specialized, sound- producing organ. The males of this species exist in two distinct morphs with different physical characteristics and sexual strategies. The Type I males have a much larger sound organ and are capable of generating a loud 100 Hz tone continuously for over an hour to attract females. This sound is produced by sonic muscle and represents one of the most superfast and super-enduring striated muscles found in nature. Each fiber contains a hollow, tubular contractile apparatus composed of radially arranged myofibrils with extremely broad Z-bands that are supported by a desmin-rich cytoskeleton. We have used micro computed tomography (CT) imaging and magnetic resonance (MR) imaging to visualize the location of the sonic organ in an intact male fish. We have also obtained high-resolution MR images of the excised swim bladders from both male types. The images of the Type I sonic organ are strikingly detailed and high- contrast, revealing both the internal organization of the bladder and the crisscrossing muscle fibers and their mode of attachment to the underlying bladder. The high-contrast variation in these images is due to different T sub(2) values for fiber bundles and the spaces between the bundles. Direct MR imaging of intact Type I sonic organ in Type I midshipman fish is a powerful approach to understanding the contraction of this superfast muscle and the oscillation of its bladder to produce mating calls, and how placement of the sonic organ in the body of the fish sheds light on its prodigious ability to produce and transmit its loud mating call. JF - Magnetic Resonance Imaging AU - Forbes, Jeffrey G AU - Morris, HDouglas AU - Wang, Kuan AD - Muscle Proteomics and Nanotechnology Section, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8024, USA, wangk@exchange.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 321 EP - 331 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 24 IS - 3 SN - 0730-725X, 0730-725X KW - Plainfin midshipman KW - Biotechnology and Bioengineering Abstracts; ASFA Marine Biotechnology Abstracts KW - Sonic muscle KW - Sarcomere KW - Wide Z-bands KW - Striated muscle KW - MRI KW - CT E-mail Article KW - Muscle contraction KW - Porichthys notatus KW - Physical characteristics KW - Oscillations KW - Urinary bladder KW - Magnetic resonance imaging KW - Muscles KW - Myofibrils KW - Cytoskeleton KW - Mating KW - Vocalization behavior KW - Computed tomography KW - Sound KW - N.M.R. KW - Swim bladder KW - Q4 27230:Sensors and communication KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19774087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Multimodal+imaging+of+the+sonic+organ+of+Porichthys+notatus%2C+the+singing+midshipman+fish&rft.au=Forbes%2C+Jeffrey+G%3BMorris%2C+HDouglas%3BWang%2C+Kuan&rft.aulast=Forbes&rft.aufirst=Jeffrey&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2005.10.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Muscle contraction; Physical characteristics; Oscillations; Urinary bladder; Magnetic resonance imaging; Muscles; Myofibrils; Cytoskeleton; Mating; Vocalization behavior; Computed tomography; Sound; N.M.R.; Swim bladder; Porichthys notatus DO - http://dx.doi.org/10.1016/j.mri.2005.10.036 ER - TY - JOUR T1 - Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells AN - 19771796; 6672909 AB - Differentiation of embryonic stem (ES) cells from a pluripotent to a committed state involves global changes in genome expression patterns. Gene activity is critically determined by chromatin structure and interactions of chromatin binding proteins. Here, we show that major architectural chromatin proteins are hyperdynamic and bind loosely to chromatin in ES cells. Upon differentiation, the hyperdynamic proteins become immobilized on chromatin. Hyperdynamic binding is a property of pluripotent cells, but not of undifferentiated cells that are already lineage committed. ES cells lacking the nucleosome assembly factor HirA exhibit elevated levels of unbound histones, and formation of embryoid bodies is accelerated. In contrast, ES cells, in which the dynamic exchange of H1 is restricted, display differentiation arrest. We suggest that hyperdynamic binding of structural chromatin proteins is a functionally important hallmark of pluripotent ES cells that contributes to the maintenance of plasticity in undifferentiated ES cells and to establishing higher-order chromatin structure. JF - Developmental Cell AU - Meshorer, Eran AU - Yellajoshula, Dhananjay AU - George, Eric AU - Scambler, Peter J AU - Brown, David T AU - Misteli, Tom AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, mistelit@mail.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 105 EP - 116 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 10 IS - 1 SN - 1534-5807, 1534-5807 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA KW - STEMCELL KW - Genomes KW - Differentiation KW - Stem cells KW - Plasticity (developmental) KW - Nucleosomes KW - Histones KW - Chromatin KW - Embryo cells KW - Embryos KW - N 14040:Genome/chromosome structure & maintenance KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19771796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Cell&rft.atitle=Hyperdynamic+Plasticity+of+Chromatin+Proteins+in+Pluripotent+Embryonic+Stem+Cells&rft.au=Meshorer%2C+Eran%3BYellajoshula%2C+Dhananjay%3BGeorge%2C+Eric%3BScambler%2C+Peter+J%3BBrown%2C+David+T%3BMisteli%2C+Tom&rft.aulast=Meshorer&rft.aufirst=Eran&rft.date=2006-01-01&rft.volume=10&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Developmental+Cell&rft.issn=15345807&rft_id=info:doi/10.1016%2Fj.devcel.2005.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Differentiation; Nucleosomes; Plasticity (developmental); Stem cells; Histones; Embryo cells; Chromatin; Embryos DO - http://dx.doi.org/10.1016/j.devcel.2005.10.017 ER - TY - JOUR T1 - Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines AN - 19770604; 6991480 AB - In order to compare the gene expression profiles of human embryonic stem cell (hESC) lines and their differentiated progeny and to monitor feeder contaminations, we have examined gene expression in seven hESC lines and human fibroblast feeder cells using Illumina super( registered )ubead arrays that contain probes for 24,131 transcript probes. A total of 48 different samples (including duplicates) grown in multiple laboratories under different conditions were analyzed and pairwise comparisons were performed in all groups. Hierarchical clustering showed that blinded duplicates were correctly identified as the closest related samples. hESC lines clustered together irrespective of the laboratory in which they were maintained. hESCs could be readily distinguished from embryoid bodies (EB) differentiated from them and the karyotypically abnormal hESC line BG01V. The embryonal carcinoma (EC) line NTera2 is a useful model for evaluating characteristics of hESCs. Expression of subsets of individual genes was validated by comparing with published databases, MPSS (Massively Parallel Signature Sequencing) libraries, and parallel analysis by microarray and RT-PCR. we show that Illumina's bead array platform is a reliable, reproducible and robust method for developing base global profiles of cells and identifying similarities and differences in large number of samples. JF - BMC Developmental Biology AU - Liu, Ying AU - Shin, Soojung AU - Zeng, Xianmin AU - Zhan, Ming AU - Gonzalez, Rodolfo AU - Mueller, Franz-Josef AU - Schwartz, Catherine M AU - Xue, Haipeng AU - Li, Huai AU - Baker, Shawn C AU - Chudin, Eugene AU - Barker, David L AU - McDaniel, Timothy K AU - Oeser, Steffen AU - Loring, Jeanne F AU - Mattson, Mark P AU - Rao, Mahendra S AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 IS - 1 SN - 1471-213X, 1471-213X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 20 KW - Genomes KW - Contamination KW - DNA probes KW - Transcription KW - DNA microarrays KW - Fibroblasts KW - Gene expression KW - Databases KW - Stem cells KW - Embryo cells KW - Polymerase chain reaction KW - Progeny KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Developmental+Biology&rft.atitle=Genome+wide+profiling+of+human+embryonic+stem+cells+%28hESCs%29%2C+their+derivatives+and+embryonal+carcinoma+cells+to+develop+base+profiles+of+U.S.+Federal+government+approved+hESC+lines&rft.au=Liu%2C+Ying%3BShin%2C+Soojung%3BZeng%2C+Xianmin%3BZhan%2C+Ming%3BGonzalez%2C+Rodolfo%3BMueller%2C+Franz-Josef%3BSchwartz%2C+Catherine+M%3BXue%2C+Haipeng%3BLi%2C+Huai%3BBaker%2C+Shawn+C%3BChudin%2C+Eugene%3BBarker%2C+David+L%3BMcDaniel%2C+Timothy+K%3BOeser%2C+Steffen%3BLoring%2C+Jeanne+F%3BMattson%2C+Mark+P%3BRao%2C+Mahendra+S&rft.aulast=Liu&rft.aufirst=Ying&rft.date=2006-01-01&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Developmental+Biology&rft.issn=1471213X&rft_id=info:doi/10.1186%2F1471-213X-6-20 L2 - http://www.biomedcentral.com/1471-213X/6/20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; Databases; Stem cells; Contamination; Embryo cells; DNA probes; Polymerase chain reaction; Transcription; Progeny; DNA microarrays; Fibroblasts DO - http://dx.doi.org/10.1186/1471-213X-6-20 ER - TY - JOUR T1 - Entry of Vaccinia Virus and Cell-Cell Fusion Require a Highly Conserved Cysteine-Rich Membrane Protein Encoded by the A16L Gene AN - 19766866; 6578369 AB - The vaccinia virus A16L open reading frame encodes a 378-amino-acid protein with a predicted C-terminal transmembrane domain and 20 invariant cysteine residues that is conserved in all sequenced members of the poxvirus family. The A16 protein was expressed late in infection and incorporated into intracellular virus particles with the N-terminal segment of the protein exposed on the surface. The cysteine residues were disulfide bonded via the poxvirus cytoplasmic redox system. Unsuccessful attempts to isolate a mutant virus with the A16L gene deleted suggested that the protein is essential for replication. To study the role of the A16 protein, we made a recombinant vaccinia virus that has the Escherichia coli lac operator system regulating transcription of the A16L gene. In the absence of inducer, A16 synthesis was repressed and plaque size and virus yield were greatly reduced. Nevertheless, virus morphogenesis occurred and normal-looking intracellular and extracellular virus particles formed. Purified virions made in the presence and absence of inducer were indistinguishable, though the latter had 60- to 100-fold-lower specific infectivity. A16-deficient virions bound to cells, but their cores did not penetrate into the cytoplasm. Furthermore, A16-deficient virions were unable to induce low-pH-triggered syncytium formation. The phenotype of the inducible A16L mutant was similar to those of mutants in which synthesis of the A21, A28, H2, or L5 membrane protein was repressed, indicating that at least five conserved viral proteins are required for entry of poxviruses into cells as well as for cell-cell fusion. JF - Journal of Virology AU - Ojeda, Suany AU - Senkevich, Tatiana G AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0445 Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 51 EP - 61 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 1 SN - 0022-538X, 0022-538X KW - A16 gene KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts KW - Virions KW - Replication KW - Morphogenesis KW - Transcription KW - Membrane proteins KW - Transmembrane domains KW - Infection KW - Cell fusion KW - Operators KW - Infectivity KW - Vaccinia virus KW - Poxvirus KW - Cysteine KW - Cytoplasm KW - Escherichia coli KW - Plaques KW - Open reading frames KW - J 02310:Genetics & Taxonomy KW - G 07313:Viruses KW - V 22042:Adsorption, penetration & uncoating UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Entry+of+Vaccinia+Virus+and+Cell-Cell+Fusion+Require+a+Highly+Conserved+Cysteine-Rich+Membrane+Protein+Encoded+by+the+A16L+Gene&rft.au=Ojeda%2C+Suany%3BSenkevich%2C+Tatiana+G%3BMoss%2C+Bernard&rft.aulast=Ojeda&rft.aufirst=Suany&rft.date=2006-01-01&rft.volume=80&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Replication; Morphogenesis; Transcription; Membrane proteins; Infection; Transmembrane domains; Cell fusion; Operators; Infectivity; Cysteine; Cytoplasm; Plaques; Open reading frames; Vaccinia virus; Poxvirus; Escherichia coli ER - TY - JOUR T1 - Proteomics study of anthrax lethal toxin-treated murine macrophages AN - 19735350; 6802231 AB - The anthrax lethal toxin (LeTx) is composed of two proteins, protective antigen and lethal factor, which bind and enter the cell through a host receptor termed the anthrax toxin receptor (ATR). In the cell, LeTx targets p38, part of the MAP kinase signaling pathway. The toxin appears to initiate an apoptotic pathway in infected cells, indicating additional downstream targets of the toxin. We have applied a proteomics approach to investigate these downstream targets and the affected processes. In this study we have used an improved strategy for fractionation based on protein pI, off-gel electrophoresis, employed in conjunction with relative quantitation using the mass labeling approach. In our survey, 67 proteins were observed and quantified from the cytosol of RAW 264.7 cells with respect to control versus toxin-treated cells. Many of these proteins are involved in the oxidative stress response, as well as apoptosis, and thus likely to be relevant to the effects of anthrax in infected cells. Our results indicate that the tumor necrosis factor-[alpha]- mediated pathway is compromised in intoxicated cells. The knowledge of such changes and the pathways leading to the changes should be of great value in understanding and combating this disease. JF - Electrophoresis AU - Kuhn, Jeffrey F AU - Hoerth, Patric AU - Hoehn, Silvia T AU - Preckel, Tobias AU - Tomer, Kenneth B AD - National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC, USA, kuhn1@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1584 EP - 1597 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 27 IS - 8 SN - 0170-0835, 0170-0835 KW - Toxicology Abstracts; Immunology Abstracts KW - Anthrax KW - Anthrax lethal toxin KW - Off-Gel super(TM) electrophoresis KW - Quantitative proteomics KW - super(18)O labeling KW - Macrophages KW - MAP kinase KW - Electrophoresis KW - Apoptosis KW - Lethal factor KW - protective antigen KW - Oxidative stress KW - Cytosol KW - proteomics KW - Quantitation KW - Signal transduction KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Proteomics+study+of+anthrax+lethal+toxin-treated+murine+macrophages&rft.au=Kuhn%2C+Jeffrey+F%3BHoerth%2C+Patric%3BHoehn%2C+Silvia+T%3BPreckel%2C+Tobias%3BTomer%2C+Kenneth+B&rft.aulast=Kuhn&rft.aufirst=Jeffrey&rft.date=2006-01-01&rft.volume=27&rft.issue=8&rft.spage=1584&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01700835&rft_id=info:doi/10.1002%2Felps.200500747 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Anthrax lethal toxin; MAP kinase; Apoptosis; Electrophoresis; Lethal factor; protective antigen; Oxidative stress; Cytosol; Anthrax; proteomics; Quantitation; Signal transduction DO - http://dx.doi.org/10.1002/elps.200500747 ER - TY - JOUR T1 - Development of Antibodies and Chimeric Molecules for Cancer Immunotherapy AN - 19721312; 7526644 AB - Monoclonal antibodies are among the most rapidly expanding class of therapeutics for cancer treatment. Monoclonal antibodies targeting non-Hodgkin's lymphoma (NHL), Her-2/neu highly expressing metastatic breast cancer, colorectal cancer, acute myelogenous leukemia, and B-cell chronic lymphocytic leukemia (CLL) have received FDA approval. Promising new targets for antibody therapy include cellular growth factor receptors, mediators of tumor-driven neo-angiogenesis, as well as host negative immunoregulatory checkpoints that impede an effective immune response to neoplasia. Antibody efficacy has been increased by genetic engineering to humanize the antibodies and to increase their effector functions including antibody dependent cellular cytotoxicity. Furthermore, antibodies have been armed with cytokines, chemotherapeutic agents, toxins, and radionuclides to augment their efficacy as tumor cytotoxic agents. As a consequence of these advances, 30 years after their first development, monoclonal antibodies have become an important standard approach for the therapy of neoplasia with 19 therapeutic monoclonal antibodies now approved by the FDA including 8 for the treatment of cancer. JF - Advances in Immunology AU - Waldmann, Thomas A AU - Morris, John C AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute NIH, Bethesda, Maryland Y1 - 2006 PY - 2006 DA - 2006 SP - 83 EP - 131 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 90 SN - 0065-2776, 0065-2776 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Special Issue: Cancer Immunotherapy KW - ErbB-2 protein KW - Acute myeloid leukemia KW - Chemotherapy KW - Immunotherapy KW - Colorectal cancer KW - Neoplasia KW - Metastases KW - Non-Hodgkin's lymphoma KW - Cytokines KW - Lymphocytes B KW - Monoclonal antibodies KW - Cytotoxic agents KW - Tumors KW - Toxins KW - Cytotoxicity KW - Genetic engineering KW - Growth factor receptors KW - Radioisotopes KW - Breast cancer KW - Immune response KW - Chronic lymphatic leukemia KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19721312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Immunology&rft.atitle=Development+of+Antibodies+and+Chimeric+Molecules+for+Cancer+Immunotherapy&rft.au=Waldmann%2C+Thomas+A%3BMorris%2C+John+C&rft.aulast=Waldmann&rft.aufirst=Thomas&rft.date=2006-01-01&rft.volume=90&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Advances+in+Immunology&rft.issn=00652776&rft_id=info:doi/10.1016%2FS0065-2776%2806%2990003-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; ErbB-2 protein; Neoplasia; Breast cancer; Chronic lymphatic leukemia; Immunotherapy; Chemotherapy; Cytokines; Cytotoxic agents; Growth factor receptors; Tumors; Genetic engineering; Acute myeloid leukemia; Toxins; Lymphocytes B; Colorectal cancer; Metastases; Non-Hodgkin's lymphoma; Immune response; Radioisotopes; Cytotoxicity DO - http://dx.doi.org/10.1016/S0065-2776(06)90003-0 ER - TY - JOUR T1 - Feasibility of conducting human studies to address bromate risks AN - 19711842; 6735535 AB - Findings from epidemiologic studies have been important in evaluating risk of exposure to many contaminants in drinking water. In the case of bromate, a byproduct of ozone disinfection of water, it is unlikely that observational studies of populations exposed to bromate in drinking water will be as revealing as studies of other contaminants, unless risks are much higher than predicted from laboratory studies of rodents. Occupational exposure to bromate has occurred in the flour milling and baking industries, as well as in chemical production of potassium bromate, used as a flour additive. The feasibility of a cohort study of bromate-exposed workers should be evaluated by studying the conditions and levels of exposure in these occupational settings. Bromate exposure causes oxidative damage to guanine bases of DNA, producing 8-hydroxy- guanine (8-OH-Gua), which is excised by 8-oxoguanosine glycosylase (OGG1) and excreted in the urine. Polymorphic variants of OGG1 in human populations have been associated with elevated cancer risk. 8-OH-Gua and 8-hydroxy-deoxyguanosine (8-OHdG) have been used as biomarkers of oxidative damage in many human studies, and it would be feasible to employ these indicators in controlled clinical experimental settings to see if exposure to bromate in water at levels close to the maximum contaminant level influences urinary levels of excretion, and if so, to help quantify the level of oxidative damage. Such a study could fill an important data gap by providing human data to help estimate the carcinogenic risk from this exposure. JF - Toxicology AU - Cantor, Kenneth P AD - Occupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Plaza South, Bethesda, MD 20892, USA, cantork@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 197 EP - 204 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 221 IS - 2-3 SN - 0300-483X, 0300-483X KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Bromate KW - Epidemiology KW - 8-Hydroxydeoxyguanosine KW - 8-Hydroxyguanine KW - Occupational studies KW - Feasibility studies KW - Disinfection KW - Byproducts KW - Guanine KW - potassium bromate KW - Carcinogenicity KW - Risk factors KW - OGG1 protein KW - Flour KW - Occupational exposure KW - Ozone KW - Bioindicators KW - Potassium KW - Population studies KW - biomarkers KW - Cancer KW - Baking KW - Urine KW - disinfection KW - DNA KW - Excretion KW - human populations KW - Drinking water KW - Contaminants KW - Additives KW - rodents KW - X 24120:Food, additives & contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Feasibility+of+conducting+human+studies+to+address+bromate+risks&rft.au=Cantor%2C+Kenneth+P&rft.aulast=Cantor&rft.aufirst=Kenneth&rft.date=2006-01-01&rft.volume=221&rft.issue=2-3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2005.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Disinfection; Population studies; biomarkers; Cancer; Baking; Guanine; potassium bromate; Urine; Risk factors; DNA; Excretion; OGG1 protein; Contaminants; Drinking water; Occupational exposure; Flour; Ozone; Feasibility studies; Bioindicators; Byproducts; Potassium; Carcinogenicity; disinfection; human populations; Additives; rodents DO - http://dx.doi.org/10.1016/j.tox.2005.11.009 ER - TY - JOUR T1 - Characterization and isolation of stem cell-enriched human hair follicle bulge cells AN - 19698553; 7485686 AB - The human hair follicle bulge is an important niche for keratinocyte stem cells (KSCs). Elucidation of human bulge cell biology could be facilitated by analysis of global gene expression profiles and identification of unique cell-surface markers. The lack of distinctive bulge morphology in human hair follicles has hampered studies of bulge cells and KSCs. In this study, we determined the distribution of label-retaining cells to define the human anagen bulge. Using navigated laser capture microdissection, bulge cells and outer root sheath cells from other follicle regions were obtained and analyzed with cDNA microarrays. Gene transcripts encoding inhibitors of WNT and activin/bone morphogenic protein signaling were overrepresented in the bulge, while genes responsible for cell proliferation were underrepresented, consistent with the existence of quiescent noncycling KSCs in anagen follicles. Positive markers for bulge cells included CD200, PHLDA1, follistatin, and frizzled homolog 1, while CD24, CD34, CD71, and CD146 were preferentially expressed by non-bulge keratinocytes. Importantly, CD200 super(x2b; ) cells (CD200 super(hi)CD24 super(lo)CD34 super(lo)CD71 super(lo)CD146 super(lo)) obtained from hair follicle suspensions demonstrated high colony-forming efficiency in clonogenic assays, indicating successful enrichment of living human bulge stem cells. The stem cell behavior of enriched bulge cells and their utility for gene therapy and hair regeneration will need to be assessed in in vivo assays. JF - Journal of Clinical Investigation AU - Ohyama, Manabu AU - Terunuma, Atsushi AU - Tock, Christine L AU - Radonovich, Michael F AU - Pise-Masison, Cynthia A AU - Hopping, Steven B AU - Brady, John N AU - Udey, Mark C AU - Vogel, Jonathan C AD - Dermatology Branch and Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. The Center for Cosmetic Surgery, Washington, DC, USA., jonvogel@mail.nih.gov. Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 249 EP - 260 PB - American Society for Clinical Investigation, 35 Research Drive, Suite 300 Ann Arbor MI 48103 USA, [mailto:asci@the-jci-org], [URL:http://www.asci-jci.org] VL - 116 IS - 1 SN - 0021-9738, 0021-9738 KW - Biotechnology and Bioengineering Abstracts KW - Wnt protein KW - CD200 antigen KW - Gene therapy KW - Follicles KW - Frizzled protein KW - CD34 antigen KW - Sheaths KW - Follistatin KW - DNA microarrays KW - Hair KW - Activin KW - Gene expression KW - Bone morphogenetic proteins KW - Stem cells KW - Regeneration KW - Lasers KW - Keratinocytes KW - Cell proliferation KW - Signal transduction KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19698553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Characterization+and+isolation+of+stem+cell-enriched+human+hair+follicle+bulge+cells&rft.au=Ohyama%2C+Manabu%3BTerunuma%2C+Atsushi%3BTock%2C+Christine+L%3BRadonovich%2C+Michael+F%3BPise-Masison%2C+Cynthia+A%3BHopping%2C+Steven+B%3BBrady%2C+John+N%3BUdey%2C+Mark+C%3BVogel%2C+Jonathan+C&rft.aulast=Ohyama&rft.aufirst=Manabu&rft.date=2006-01-01&rft.volume=116&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI26043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Follicles; Hair; Stem cells; Keratinocytes; Frizzled protein; Gene therapy; Gene expression; Sheaths; Activin; DNA microarrays; Lasers; Bone morphogenetic proteins; CD34 antigen; Cell proliferation; Regeneration; Signal transduction; Follistatin; CD200 antigen; Wnt protein DO - http://dx.doi.org/10.1172/JCI26043 ER - TY - JOUR T1 - EasyExonPrimer: Automated Primer Design for Exon Sequences AN - 19696232; 7479083 AB - EasyExonPrimer is a web-based software that automates the design of PCR primers to amplify exon sequences from genomic DNA. EasyExonPrimer is written in Perl and uses Primer3 to design PCR primers based on the genome builds and annotation databases available at the University of California, Santa Cruz (UCSC) Genome Browser database (http://genome.ucsc.edu/). It masks repeats and known single nucleotide polymorphism (SNP) sites in the genome and designs standardised primers using optimised conditions. Users can input genes by RefSeq mRNA ID, gene name or keyword. The primer design is optimised for large- scale resequencing of exons. For exons larger than 1kb, the user has the option of breaking the exon sequence down into overlapping smaller fragments. All primer pairs are then verified using the In-Silico PCR software to test for uniqueness in the genome. We have designed >1000 pairs of primers for 90 genes; 95% of the primer pairs successfully amplified exon sequences under standard PCR conditions without requiring further optimisation. Availability: EasyExonPrimer is available from http://129.43.22.27/ similar to primer/. The source code is also available upon request. Contact: Xiaolin Wu (forestwuail.nih.gov) JF - Applied Bioinformatics AU - Wu, Xiaolin AU - Munroe, David J AD - Laboratory of Molecular Technology, Scientific Application International Corporation - Frederick, National Cancer Institute at Frederick, Frederick, Maryland, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 119 EP - 120 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 5 IS - 2 SN - 1175-5636, 1175-5636 KW - Biotechnology and Bioengineering Abstracts KW - Bioinformatics KW - Computers KW - Genomics KW - Genomes KW - Exons KW - Nucleotide sequence KW - mRNA KW - Computer programs KW - Databases KW - double prime Id protein KW - software KW - Single-nucleotide polymorphism KW - Polymerase chain reaction KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19696232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Bioinformatics&rft.atitle=EasyExonPrimer%3A+Automated+Primer+Design+for+Exon+Sequences&rft.au=Wu%2C+Xiaolin%3BMunroe%2C+David+J&rft.aulast=Wu&rft.aufirst=Xiaolin&rft.date=2006-01-01&rft.volume=5&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Applied+Bioinformatics&rft.issn=11755636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; double prime Id protein; Databases; Computer programs; software; Single-nucleotide polymorphism; Exons; Nucleotide sequence; Polymerase chain reaction; genomics; Bioinformatics; mRNA ER - TY - JOUR T1 - WebaCGH: An Interactive Online Tool for the Analysis and Display of Array Comparative Genomic Hybridisation Data AN - 19693440; 7479085 AB - Gene copy number variations occur both in normal cells and in numerous pathologies including cancer and developmental diseases. Array comparative genomic hybridisation (aCGH) is an emerging technology that allows detection of chromosomal gains and losses in a high-resolution format. When aCGH is performed on cDNA and oligonucleotide microarrays, the impact of DNA copy number on gene transcription profiles may be directly compared. We have created an online software tool, WebaCGH, that functions to (i) upload aCGH and gene transcription results from multiple experiments; (ii) identify significant aberrant regions using a local Z-score threshold in user-selected chromosomal segments subjected to smoothing with moving averages; and (iii) display results in a graphical format with full genome and individual chromosome views. In the individual chromosome display, data can be zoomed in/out in both dimensions (i.e. ratio and physical location) and plotted features can have `mouse over linking to outside databases to identify loci of interest. Uploaded data can be stored indefinitely for subsequent retrieval and analysis. WebaCGH was created as a Java-based web application using the open-source database MySQL sub( registered ). Availability: WebaCGH is freely accessible at http://129.43.22.27/WebaCGH/welcome.htm Contact: Xiaolin Wu (forestwuail.nih.gov) or Ulises Urzua (uurzuaed.uchile.cl) JF - Applied Bioinformatics AU - Frankenberger, Casey AU - Wu, Xiaolin AU - Harmon, Jerry AU - Church, Deanna AU - Gangi, Lisa M AU - Munroe, David J AU - Urzua, Ulises AD - 1 Laboratory of Molecular Technology, Scientific Application International Corporation (SAIC) - Frederick, Inc., National Cancer Institute - Frederick, Frederick, Maryland, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 125 EP - 130 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 5 IS - 2 SN - 1175-5636, 1175-5636 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Bioinformatics KW - Computers KW - Genomes KW - Data processing KW - Computer graphics KW - Transcription KW - Oligonucleotides KW - DNA microarrays KW - Cancer KW - copy number KW - Computer programs KW - Databases KW - software KW - Chromosomes KW - genomics KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19693440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Bioinformatics&rft.atitle=WebaCGH%3A+An+Interactive+Online+Tool+for+the+Analysis+and+Display+of+Array+Comparative+Genomic+Hybridisation+Data&rft.au=Frankenberger%2C+Casey%3BWu%2C+Xiaolin%3BHarmon%2C+Jerry%3BChurch%2C+Deanna%3BGangi%2C+Lisa+M%3BMunroe%2C+David+J%3BUrzua%2C+Ulises&rft.aulast=Frankenberger&rft.aufirst=Casey&rft.date=2006-01-01&rft.volume=5&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Applied+Bioinformatics&rft.issn=11755636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Computer graphics; Transcription; DNA microarrays; Oligonucleotides; Cancer; copy number; Databases; Computer programs; Chromosomes; software; genomics; Bioinformatics ER - TY - JOUR T1 - The National Eye Health Education Program: Increasing Awareness of Diabetic Eye Disease Among American Indians and Alaska Natives AN - 19604745; 7312812 AB - With the highest prevalence of diabetes in the United States, American Indians and Alaska Natives are at greatest risk for diabetic eye disease (DED), a leading cause of blindness. The National Eye Institute (NEI) conducted formative research to understand DED-related knowledge, identify approaches to managing this disease, and design a communication plan to increase awareness and reduce DED among these populations. The NEI conducted qualitative research at five locations in Indian country with representatives from national organizations, tribal members, and healthcare providers. While diabetes ranked high on their list of primary community health issues in need of attention, study participants had only a basic level of diabetes-related knowledge, acknowledged the need for DED education, and underscored the importance of the use of interpersonal and culturally appropriate communication strategies. This is the first exploratory qualitative research study to examine the status of diabetic eye disease among American Indians and Alaska Natives whose primary purpose was to inform the design of a national DED communication campaign. JF - Ethnicity & Disease AU - Silver, Karen AU - Williams, Meredith AU - Macario, Everly AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland (KS); IQ Solutions, Contractors, Rockville (MW, EM), Maryland Y1 - 2006 PY - 2006 DA - 2006 SP - 920 EP - 925 PB - International Society on Hypertension in Blacks, 2045 Manchester St, NE Atlanta GA 30324 USA, [URL:http://www.ishib.org] VL - 16 IS - 4 SN - 1049-510X, 1049-510X KW - Risk Abstracts KW - Diabetes mellitus KW - Education KW - Prevention KW - Communications KW - Eye KW - INE, USA, Alaska KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19604745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Disease&rft.atitle=The+National+Eye+Health+Education+Program%3A+Increasing+Awareness+of+Diabetic+Eye+Disease+Among+American+Indians+and+Alaska+Natives&rft.au=Silver%2C+Karen%3BWilliams%2C+Meredith%3BMacario%2C+Everly&rft.aulast=Silver&rft.aufirst=Karen&rft.date=2006-01-01&rft.volume=16&rft.issue=4&rft.spage=920&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Disease&rft.issn=1049510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Prevention; Education; Communications; Eye; Ethnic groups; INE, USA, Alaska ER - TY - JOUR T1 - Temporal order of evolution of DNA replication systems inferred by comparison of cellular and viral DNA polymerases AN - 19564614; 7280266 AB - The core enzymes of the DNA replication systems show striking diversity among cellular life forms and more so among viruses. In particular, and counter- intuitively, given the central role of DNA in all cells and the mechanistic uniformity of replication, the core enzymes of the replication systems of bacteria and archaea (as well as eukaryotes) are unrelated or extremely distantly related. Viruses and plasmids, in addition, possess at least two unique DNA replication systems, namely, the protein-primed and rolling circle modalities of replication. This unexpected diversity makes the origin and evolution of DNA replication systems a particularly challenging and intriguing problem in evolutionary biology. Results I propose a specific succession for the emergence of different DNA replication systems, drawing argument from the differences in their representation among viruses and other selfish replicating elements. In a striking pattern, the DNA replication systems of viruses infecting bacteria and eukaryotes are dominated by the archaeal-type B-family DNA polymerase (PolB) whereas the bacterial replicative DNA polymerase (PolC) is present only in a handful of bacteriophage genomes. There is no apparent mechanistic impediment to the involvement of the bacterial-type replication machinery in viral DNA replication. Therefore, I hypothesize that the observed, markedly unequal distribution of the replicative DNA polymerases among the known cellular and viral replication systems has a historical explanation. I propose that, among the two types of DNA replication machineries that are found in extant life forms, the archaeal-type, PolB-based system evolved first and had already given rise to a variety of diverse viruses and other selfish elements before the advent of the bacterial, PolC-based machinery. Conceivably, at that stage of evolution, the niches for DNA-viral reproduction have been already filled with viruses replicating with the help of the archaeal system, and viruses with the bacterial system never took off. I further suggest that the two other systems of DNA replication, the rolling circle mechanism and the protein- primed mechanism, which are represented in diverse selfish elements, also evolved prior to the emergence of the bacterial replication system. This hypothesis is compatible with the distinct structural affinities of PolB, which has the palm-domain fold shared with reverse transcriptases and RNA-dependent RNA polymerases, and PolC that has a distinct, unrelated nucleotidyltransferase fold. I propose that PolB is a descendant of polymerases that were involved in the replication of genetic elements in the RNA-protein world, prior to the emergence of DNA replication. By contrast, PolC might have evolved from an ancient non-templated polymerase, e.g., polyA polymerase. The proposed temporal succession of the evolving DNA replication systems does not depend on the specific scenario adopted for the evolution of cells and viruses, i.e., whether viruses are derived from cells or virus-like elements are thought to originate from a primordial gene pool. However, arguments are presented in favor of the latter scenario as the most parsimonious explanation of the evolution of DNA replication systems. Conclusion Comparative analysis of the diversity of genomic strategies and organizations of viruses and cellular life forms has the potential to open windows into the deep past of life's evolution, especially, with the regard to the origin of genome replication systems. When complemented with information on the evolution of the relevant protein folds, this comparative approach can yield credible scenarios for very early steps of evolution that otherwise appear to be out of reach. Reviewers Eric Bapteste, Patrick Forterre, and Mark Ragan. JF - Biology Direct AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, koonin@ncbi.nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1745-6150, 1745-6150 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Article No. 39 KW - Genomes KW - Phages KW - DNA biosynthesis KW - Archaea KW - Gene pool KW - Temporal variations KW - Replication KW - Niches KW - Enzymes KW - Plasmids KW - Succession KW - RNA-directed RNA polymerase KW - DNA-directed DNA polymerase KW - Replication origins KW - RNA-directed DNA polymerase KW - Reproduction KW - genomics KW - Evolution KW - V 22320:Replication KW - N 14835:Protein-Nucleic Acids Association KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19564614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=Temporal+order+of+evolution+of+DNA+replication+systems+inferred+by+comparison+of+cellular+and+viral+DNA+polymerases&rft.au=Koonin%2C+Eugene+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=17456150&rft_id=info:doi/10.1186%2F1745-6150-1-39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Genomes; DNA biosynthesis; Gene pool; Replication; Temporal variations; Niches; Enzymes; Succession; Plasmids; DNA-directed DNA polymerase; RNA-directed RNA polymerase; Replication origins; RNA-directed DNA polymerase; Reproduction; genomics; Evolution; Archaea DO - http://dx.doi.org/10.1186/1745-6150-1-39 ER - TY - JOUR T1 - H. pylori-infection and antibody immune response in a rural Tanzanian population AN - 19534390; 7247748 AB - Background: Helicobacter pylori (H. pylori) infection is ubiquitous in sub-Saharan Africa, but paradoxically gastric cancer is rare. Methods Sera collected during a household-based survey in rural Tanzania in 1985 were tested for anti-H. pylori IgG and IgG subclass antibodies by enzyme immunoassay. Odds ratios (OR) and confidence intervals (CI) of association of seropositivity with demographic variables were computed by logistic regression models. Results Of 788 participants, 513 were aged =18 years of age. Seropositivity was associated with age (OR 11.5, 95% CI 4.2-31.4 for 10-17 vs. 0-4 years), higher birth-order (11.1; 3.6-34.1 for >=3 super(rd )vs. 1 super(st )born), and having a seropositive next-older sibling (2.7; 0.9-8.3). Median values of IgG subclass were 7.2 for IgG1 and 2.0 for IgG2. The median IgG1/IgG2 ratio was 3.1 (IQR: 1.7-5.6), consistent with a Th2-dominant immune profile. Th2-dominant response was more frequent in children than adults (OR 2.4, 95% CI 1.3-4.4). Conclusion H. pylori seropositivity was highly prevalent in Tanzania and the immunological response was Th2-dominant. Th2-dominant immune response, possibly caused by concurrent bacterial or parasitic infections, could explain, in part, the lower risk of H. pylori-associated gastric cancer in Africa. JF - Infectious Agents and Cancer AU - Mbulaiteye, Sam M AU - Gold, Benjamin D AU - Pfeiffer, Ruth M AU - Brubaker, Glen R AU - Shao, John AU - Biggar, Robert J AU - Hisada, Michie AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA, mbulaits@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1750-9378, 1750-9378 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Article No. 3 KW - Helicobacter pylori KW - Infection KW - Children KW - Models KW - Enzyme immunoassay KW - Demography KW - Risk factors KW - Immunoglobulin G KW - Regression analysis KW - Siblings KW - Immune response KW - Gastric cancer KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19534390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+Agents+and+Cancer&rft.atitle=H.+pylori-infection+and+antibody+immune+response+in+a+rural+Tanzanian+population&rft.au=Mbulaiteye%2C+Sam+M%3BGold%2C+Benjamin+D%3BPfeiffer%2C+Ruth+M%3BBrubaker%2C+Glen+R%3BShao%2C+John%3BBiggar%2C+Robert+J%3BHisada%2C+Michie&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Infectious+Agents+and+Cancer&rft.issn=17509378&rft_id=info:doi/10.1186%2F1750-9378-1-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Demography; Risk factors; Regression analysis; Immunoglobulin G; Siblings; Immune response; Children; Infection; Gastric cancer; Enzyme immunoassay; Models; Helicobacter pylori DO - http://dx.doi.org/10.1186/1750-9378-1-3 ER - TY - JOUR T1 - Technical development of PubMed interact: an improved interface for MEDLINE/PubMed searches AN - 19530738; 7249142 AB - The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM) which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhancing user interactivity through client-side manipulation and management of results. Results PubMed Interact is a Web-based MEDLINE/PubMed search application built with HTML, JavaScript and PHP. It is implemented on a Windows Server 2003 with Apache 2.0.52, PHP 4.4.1 and MySQL 4.1.18. PHP scripts provide the backend engine that connects with E-Utilities and parses XML files. JavaScript manages client-side functionalities and converts Web pages into interactive platforms using dynamic HTML (DHTML), Document Object Model (DOM) tree manipulation and Ajax methods. With PubMed Interact, users can limit searches with JavaScript slider bars, preview result counts, delete citations from the list, display and add related articles and create relevance lists. Many interactive features occur at client-side, which allow instant feedback without reloading or refreshing the page resulting in a more efficient user experience. Conclusion PubMed Interact is a highly interactive Web-based search application for MEDLINE/PubMed that explores recent trends in Web technologies like DOM tree manipulation and Ajax. It may become a valuable technical development for online medical search applications. JF - BMC Medical Informatics and Decision Making AU - Muin, Michael AU - Fontelo, Paul AD - Office of High Performance Computing and Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, Maryland 20894, USA, mmuin@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 SN - 1472-6947, 1472-6947 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 36 KW - Decision making KW - Feedback KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19530738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=Technical+development+of+PubMed+interact%3A+an+improved+interface+for+MEDLINE%2FPubMed+searches&rft.au=Muin%2C+Michael%3BFontelo%2C+Paul&rft.aulast=Muin&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=6&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=14726947&rft_id=info:doi/10.1186%2F1472-6947-6-36 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Decision making; Feedback; Models DO - http://dx.doi.org/10.1186/1472-6947-6-36 ER - TY - JOUR T1 - The influence of tumor oxygenation on super(18)F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET) AN - 19491027; 7181504 AB - Background: This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of super(18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). Results Tumor-bearing mice (squamous cell carcinoma) maintained at 37 degree C were studied while breathing either normal air or carbogen (95% O sub(2), 5% CO sub(2)), known to significantly oxygenate tumors. Tumor activity was measured within an automatically determined volume of interest (VOI). Activity was corrected for the arterial input function as estimated from image and blood-derived data. Tumor FDG uptake was initially evaluated for tumor-bearing animals breathing only air (2 animals) or only carbogen (2 animals). Subsequently, 5 animals were studied using two sequential super(18)F-FDG injections administered to the same tumor-bearing mouse, 60 min apart; the first injection on one gas (air or carbogen) and the second on the other gas. When examining the entire tumor VOI, there was no significant difference of super(18)F- FDG uptake between mice breathing either air or carbogen (i.e. air/carbogen ratio near unity). However, when only the highest super(18)F-FDG uptake regions of the tumor were considered (small VOIs), there was a modest (21%), but significant increase in the air/carbogen ratio suggesting that in these potentially most hypoxic regions of the tumor, super(18)F-FDG uptake and hence glucose metabolism, may be reduced by increasing tumor oxygenation. Conclusion Tumor super(18)F-FDG uptake may be reduced by increases in tumor oxygenation and thus may provide a means to further enhance super(18)F-FDG functional imaging. JF - Radiation Oncology AU - Chan, Linda W AU - Hapdey, Sebastien AU - English, Sean AU - Seidel, Jurgen AU - Carson, Joann AU - Sowers, Anastasia L AU - Krishna, Murali C AU - Green, Michael V AU - Mitchell, James B AU - Bacharach, Stephen L AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, LindaWChan Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1748-717X, 1748-717X KW - Biotechnology and Bioengineering Abstracts KW - Article No. 3 KW - deoxyglucose KW - Blood KW - Radiation KW - Hypoxia KW - Respiration KW - Positron emission tomography KW - Oncology KW - squamous cell carcinoma KW - Glucose metabolism KW - Tumors KW - Carbon dioxide KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Oncology&rft.atitle=The+influence+of+tumor+oxygenation+on+super%2818%29F-FDG+%28Fluorine-18+Deoxyglucose%29+uptake%3A+A+mouse+study+using+positron+emission+tomography+%28PET%29&rft.au=Chan%2C+Linda+W%3BHapdey%2C+Sebastien%3BEnglish%2C+Sean%3BSeidel%2C+Jurgen%3BCarson%2C+Joann%3BSowers%2C+Anastasia+L%3BKrishna%2C+Murali+C%3BGreen%2C+Michael+V%3BMitchell%2C+James+B%3BBacharach%2C+Stephen+L&rft.aulast=Chan&rft.aufirst=Linda&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Radiation+Oncology&rft.issn=1748717X&rft_id=info:doi/10.1186%2F1748-717X-1-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Positron emission tomography; Respiration; Glucose metabolism; deoxyglucose; Carbon dioxide; Blood; Radiation; squamous cell carcinoma; Hypoxia; Oncology DO - http://dx.doi.org/10.1186/1748-717X-1-3 ER - TY - JOUR T1 - Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided High Dose Rate brachytherapy boost AN - 19477399; 7155340 AB - Purpose To report early observation of transient PSA elevations on this pilot study of external beam radiation therapy and magnetic resonance imaging (MRI) guided high dose rate (HDR) brachytherapy boost. Materials and methods Eleven patients with intermediate-risk and high-risk localized prostate cancer received MRI guided HDR brachytherapy (10.5 Gy each fraction) before and after a course of external beam radiotherapy (46 Gy). Two patients continued on hormones during follow-up and were censored for this analysis. Four patients discontinued hormone therapy after RT. Five patients did not receive hormones. PSA bounce is defined as a rise in PSA values with a subsequent fall below the nadir value or to below 20% of the maximum PSA level. Six previously published definitions of biochemical failure to distinguish true failure from were tested: definition 1, rise >0.2 ng/mL; definition 2, rise >0.4 ng/mL; definition 3, rise >35% of previous value; definition 4, ASTRO defined guidelines, definition 5 nadir + 2 ng/ml, and definition 6, nadir + 3 ng/ml. Results Median follow-up was 24 months (range 18-36 mo). During follow-up, the incidence of transient PSA elevation was: 55% for definition 1, 44% for definition 2, 55% for definition 3, 33% for definition 4, 11% for definition 5, and 11% for definition 6. Conclusion We observed a substantial incidence of transient elevations in PSA following combined external beam radiation and HDR brachytherapy for prostate cancer. Such elevations seem to be self-limited and should not trigger initiation of salvage therapies. No definition of failure was completely predictive. JF - Radiation Oncology AU - Singh, Anurag K AU - Guion, Peter AU - Susil, Robert C AU - Citrin, Deborah E AU - Ning, Holly AU - Miller, Robert W AU - Ullman, Karen AU - Smith, Sharon AU - Crouse, Nancy Sears AU - Godette, Denise J AU - Stall, Bronwyn R AU - Coleman, C Norman AU - Camphausen, Kevin AU - Menard, Cynthia AD - Radiation Oncology Branch, National Cancer Institute, NIH-DHHS, Bldg 10, CRC Rm B2-3561, 9000 Rockville Pike, Bethesda, MD, 20892, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 1 SN - 1748-717X, 1748-717X KW - Risk Abstracts KW - Article No. 28 KW - Radiation therapy KW - Dose-response effects KW - Hormones KW - Cancer KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Oncology&rft.atitle=Early+observed+transient+prostate-specific+antigen+elevations+on+a+pilot+study+of+external+beam+radiation+therapy+and+fractionated+MRI+guided+High+Dose+Rate+brachytherapy+boost&rft.au=Singh%2C+Anurag+K%3BGuion%2C+Peter%3BSusil%2C+Robert+C%3BCitrin%2C+Deborah+E%3BNing%2C+Holly%3BMiller%2C+Robert+W%3BUllman%2C+Karen%3BSmith%2C+Sharon%3BCrouse%2C+Nancy+Sears%3BGodette%2C+Denise+J%3BStall%2C+Bronwyn+R%3BColeman%2C+C+Norman%3BCamphausen%2C+Kevin%3BMenard%2C+Cynthia&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-01-01&rft.volume=1&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Radiation+Oncology&rft.issn=1748717X&rft_id=info:doi/10.1186%2F1748-717X-1-28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Radiation therapy; Dose-response effects; Hormones; Cancer DO - http://dx.doi.org/10.1186/1748-717X-1-28 ER - TY - JOUR T1 - The magnocellular medial preoptic nucleus I. sources of afferent input AN - 19474586; 7171243 AB - The magnocellular medial preoptic nucleus plays a crucial role in the regulation of male sexual behavior in Syrian hamsters. Histological and behavioral studies suggest that the magnocellular medial preoptic nucleus regulates male mating behavior by integrating chemosensory and hormonal signals. The present study is the first to systematically identify the afferent connections of the magnocellular medial preoptic nucleus by tracing the uptake of cholera toxin B from deposits in the magnocellular medial preoptic nucleus of adult male Syrian hamsters. Our findings indicate that the magnocellular medial preoptic nucleus receives 1) chemosensory input from areas in the main and accessory olfactory pathways including the posterior medial bed nucleus of the stria terminalis, anterior medial, anterior cortical and posterior cortical nuclei of the amygdala; 2) input from steroid responsive structures such as the posterior medial nucleus of the amygdala, bed nucleus of the stria terminalis, lateral septum, anteroventral periventricular nucleus, medial preoptic nucleus, ventromedial nucleus of the hypothalamus and arcuate nucleus; 3) input from structures in the brainstem such as the subparafascicular thalamic nucleus, peripeduncular nucleus and the premamillary nucleus in the hypothalamus that carry sensory information from the genitalia. The major afferent input to the magnocellular medial preoptic nucleus was confirmed by injecting anterograde tracer biotinylated dextran amine into the anterior medical nucleus of the amygdala, the posterodorsal part of the medial nucleus of the amygdala, the posteromedial part of the bed nucleus of the stria terminalis and the posterointermediate part of the bed nucleus of the stria terminalis. Our results support the hypothesis that the magnocellular medial preoptic nucleus is part of the chemosensory pathway that receives chemosensory and hormonal input to regulate mating behavior and suggest that the magnocellular medial preoptic nucleus may utilize information from the genitalia to regulate male mating behavior. JF - Neuroscience AU - Wang, J AU - Swann, J M AD - Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892, USA, jms5@lehigh.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 1437 EP - 1456 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 141 IS - 3 SN - 0306-4522, 0306-4522 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Arcuate nucleus KW - Sexual behavior KW - Thalamus KW - Olfactory pathways KW - Tracers KW - amines KW - Nervous system KW - Cholera toxin KW - Information processing KW - bed nucleus KW - Septum KW - Dextran KW - Mating behavior KW - Stria terminalis KW - Deposits KW - Sensory neurons KW - Brain stem KW - Genitalia KW - Periventricular nucleus KW - Steroid hormones KW - Chemoreception KW - ventromedial nucleus KW - Amygdala KW - medial preoptic nucleus KW - J 02310:Genetics & Taxonomy KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=The+magnocellular+medial+preoptic+nucleus+I.+sources+of+afferent+input&rft.au=Wang%2C+J%3BSwann%2C+J+M&rft.aulast=Wang&rft.aufirst=J&rft.date=2006-01-01&rft.volume=141&rft.issue=3&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2006.04.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stria terminalis; Mating behavior; Dextran; Deposits; Sensory neurons; Brain stem; Genitalia; Steroid hormones; Periventricular nucleus; Arcuate nucleus; Sexual behavior; Thalamus; Chemoreception; Olfactory pathways; Tracers; ventromedial nucleus; Nervous system; amines; Cholera toxin; Information processing; bed nucleus; Amygdala; Septum; medial preoptic nucleus DO - http://dx.doi.org/10.1016/j.neuroscience.2006.04.079 ER - TY - JOUR T1 - MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice AN - 19470285; 7035099 AB - Successful outcomes for patients with cancer often depend on the early detection of tumor and the prompt initiation of active therapy. Despite major advances in the treatment of many cancers, early-stage lesions often go undetected due to the suboptimal resolution of current anatomical and functional imaging modalities. This limitation also applies to preclinical animal tumor models that are crucial for the evaluation and development of new therapeutic approaches to cancer. We report a new mouse model of metastatic pheochromocytoma, generated using tail vein injection of the mouse pheochromocytoma cell (MPC) line that reproducibly generated multiple liver tumors in the animals. Furthermore, we show that in vivo microCT imaging enhanced using a hepatobiliary-specific contrast agent, glyceryl-2-oleyl-1,3-di- 7-(3-amino-2,4,6-triiodophenyl)-heptanoate (DHOG), detected tumors as small as 0.35 mm as early as 4 weeks after the injection of the tumor cells. This model may be useful for in vivo studies of tumor biology and for development of new strategies to treat metastatic pheochromocytoma. JF - International Journal of Cancer AU - Ohta, Shoichiro AU - Lai, Edwin W AU - Morris, John C AU - Bakan, Douglas A AU - Klaunberg, Brenda AU - Cleary, Susannah AU - Powers, James F AU - Tischler, Arthur S AU - Abu-Asab, Mones AU - Schimel, Daniel AU - Pacak, Karel AD - Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, MD, karel@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 2236 EP - 2241 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 9 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts KW - Tails KW - Animal models KW - Tumors KW - Tumor cells KW - imaging KW - Pheochromocytoma KW - Cancer KW - Metastases KW - Veins KW - Pheochromocytoma cells KW - Computed tomography KW - Contrast media KW - Liver KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=MicroCT+for+high-resolution+imaging+of+ectopic+pheochromocytoma+tumors+in+the+liver+of+nude+mice&rft.au=Ohta%2C+Shoichiro%3BLai%2C+Edwin+W%3BMorris%2C+John+C%3BBakan%2C+Douglas+A%3BKlaunberg%2C+Brenda%3BCleary%2C+Susannah%3BPowers%2C+James+F%3BTischler%2C+Arthur+S%3BAbu-Asab%2C+Mones%3BSchimel%2C+Daniel%3BPacak%2C+Karel&rft.aulast=Ohta&rft.aufirst=Shoichiro&rft.date=2006-01-01&rft.volume=119&rft.issue=9&rft.spage=2236&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; imaging; Animal models; Cancer; Pheochromocytoma; Computed tomography; Liver; Metastases; Contrast media; Pheochromocytoma cells; Tails; Tumor cells; Veins DO - http://dx.doi.org/10.1002/ijc.22127 ER - TY - JOUR T1 - Distinct perisynaptic and synaptic localization of NMDA and AMPA receptors on ganglion cells in rat retina AN - 19463579; 7025976 AB - At most excitatory synapses, AMPA and NMDA receptors (AMPARs and NMDARs) occupy the postsynaptic density (PSD) and contribute to miniature excitatory postsynaptic currents (mEPSCs) elicited by single transmitter quanta. Juxtaposition of AMPARs and NMDARs may be crucial for certain types of synaptic plasticity, although extrasynaptic NMDARs may also contribute. AMPARs and NMDARs also contribute to evoked EPSCs in retinal ganglion cells (RGCs), but mEPSCs are mediated solely by AMPARs. Previous work indicates that an NMDAR component emerges in mEPSCs when glutamate uptake is reduced, suggesting that NMDARs are located near the release site but perhaps not directly beneath in the PSD. Consistent with this idea, NMDARs on RGCs encounter a lower glutamate concentration during synaptic transmission than do AMPARs. To understand better the roles of NMDARs in RGC function, we used immunohistochemical and electron microscopic techniques to determine the precise subsynaptic localization of NMDARs in RGC dendrites. RGC dendrites were labeled retrogradely with cholera toxin B subunit (CTB) injected into the superior colliculus (SC) and identified using postembedding immunogold methods. Colabeling with antibodies directed toward AMPARs and/or NMDARs, we found that nearly all AMPARs are located within the PSD, while most NMDARs are located perisynaptically, 100-300 nm from the PSD. This morphological evidence for exclusively perisynaptic NMDARs localizations suggests a distinct role for NMDARs in RGC function. J. Comp. Neurol. 498:810-820, 2006. Published 2006 Wiley-Liss, Inc. JF - Journal of Comparative Neurology AU - Zhang, Jun AU - Diamond, Jeffrey S AD - Synaptic Physiology Unit, National Institute of Neurological Disorders and e, National Institutes of Health, Bethesda Maryland 20892-3701, diamondj@ninds.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 810 EP - 820 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 498 IS - 6 SN - 0021-9967, 0021-9967 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - NMDA KW - AMPA KW - synaptic and perisynaptic distribution KW - postembedding immunogold KW - retinal ganglion cell KW - Excitatory postsynaptic potentials KW - N-Methyl-D-aspartic acid receptors KW - Synapses KW - Retina KW - Retinal ganglion cells KW - postsynaptic density KW - Dendrites KW - Plasticity (synaptic) KW - Glutamic acid receptors KW - Superior colliculus KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Glutamic acid receptors (ionotropic) KW - a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid KW - Antibodies KW - cholera toxin B subunit KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid KW - Glutamic acid KW - Synaptic transmission KW - a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - J 02410:Animal Diseases KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Neurology&rft.atitle=Distinct+perisynaptic+and+synaptic+localization+of+NMDA+and+AMPA+receptors+on+ganglion+cells+in+rat+retina&rft.au=Zhang%2C+Jun%3BDiamond%2C+Jeffrey+S&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2006-01-01&rft.volume=498&rft.issue=6&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Neurology&rft.issn=00219967&rft_id=info:doi/10.1002%2Fcne.21089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Excitatory postsynaptic potentials; Synapses; N-Methyl-D-aspartic acid receptors; Retina; Retinal ganglion cells; postsynaptic density; Dendrites; Plasticity (synaptic); alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; Superior colliculus; Glutamic acid receptors; Glutamic acid receptors (ionotropic); a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; Antibodies; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; cholera toxin B subunit; Synaptic transmission; Glutamic acid; a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors DO - http://dx.doi.org/10.1002/cne.21089 ER - TY - JOUR T1 - AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies AN - 19463484; 7074806 AB - Monoclonal antibodies are used extensively throughout the biomedical sciences for detection of antigens, either in vitro or in vivo. We, for example, have used them for quantitation of proteins on "reverse-phase" protein lysate arrays. For those studies, we quality-controlled > 600 available monoclonal antibodies and also needed to develop precise information on the genes that encode their antigens. Translation among the various protein and gene identifier types proved non-trivial because of one-to-many and many-to-one relationships. To organize the antibody, protein, and gene information, we initially developed a relational database in Filemaker for our own use. When it became apparent that the information would be useful to many other researchers faced with the need to choose or characterize antibodies, we developed it further as AbMiner, a fully relational web-based database under MySQL, programmed in Java. AbMiner is a user-friendly, web-based relational database of information on > 600 commercially available antibodies that we validated by Western blot for protein microarray studies. It includes many types of information on the antibody, the immunogen, the vendor, the antigen, and the antigen's gene. Multiple gene and protein identifier types provide links to corresponding entries in a variety of other public databases, including resources for phosphorylation-specific antibodies. AbMiner also includes our quality-control data against a pool of 60 diverse cancer cell types (the NCI-60) and also protein expression levels for the NCI-60 cells measured using our high-density "reverse-phase" protein lysate microarrays for a selection of the listed antibodies. Some other available database resources give information on antibody specificity for one or a couple of cell types. In contrast, the data in AbMiner indicate specificity with respect to the antigens in a pool of 60 diverse cell types from nine different tissues of origin. AbMiner is a relational database that provides extensive information from our own laboratory and other sources on more than 600 available antibodies and the genes that encode the antibodies' antigens. The data will be made freely available at http://discover.nci.nih.gov/abminer JF - BMC Bioinformatics AU - Major, Sylvia M AU - Nishizuka, Satoshi AU - Morita, Daisaku AU - Rowland, Rick AU - Sunshine, Margot AU - Shankavaram, Uma AU - Washburn, Frank AU - Asin, Daniel AU - Kouros-Mehr, Hosein AU - Kane, David AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 192 KW - Western blotting KW - Translation KW - Data processing KW - Monoclonal antibodies KW - DNA microarrays KW - Cancer KW - Computer programs KW - Databases KW - Antibodies KW - Protein arrays KW - proteomics KW - genomics KW - Bioinformatics KW - Quantitation KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=AbMiner%3A+A+bioinformatic+resource+on+available+monoclonal+antibodies+and+corresponding+gene+identifiers+for+genomic%2C+proteomic%2C+and+immunologic+studies&rft.au=Major%2C+Sylvia+M%3BNishizuka%2C+Satoshi%3BMorita%2C+Daisaku%3BRowland%2C+Rick%3BSunshine%2C+Margot%3BShankavaram%2C+Uma%3BWashburn%2C+Frank%3BAsin%2C+Daniel%3BKouros-Mehr%2C+Hosein%3BKane%2C+David%3BWeinstein%2C+John+N&rft.aulast=Major&rft.aufirst=Sylvia&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-192 L2 - http://www.biomedcentral.com/1471-2105/7/192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Western blotting; Data processing; Monoclonal antibodies; DNA microarrays; Cancer; Databases; Computer programs; Antibodies; Protein arrays; Bioinformatics; genomics; proteomics; Quantitation DO - http://dx.doi.org/10.1186/1471-2105-7-192 ER - TY - JOUR T1 - Bias in error estimation when using cross-validation for model selection AN - 19456883; 6970594 AB - Cross-validation (CV) is an effective method for estimating the prediction error of a classifier. Some recent articles have proposed methods for optimizing classifiers by choosing classifier parameter values that minimize the CV error estimate. We have evaluated the validity of using the CV error estimate of the optimized classifier as an estimate of the true error expected on independent data. We used CV to optimize the classification parameters for two kinds of classifiers; Shrunken Centroids and Support Vector Machines (SVM). Random training datasets were created, with no difference in the distribution of the features between the two classes. Using these "null" datasets, we selected classifier parameter values that minimized the CV error estimate. 10-fold CV was used for Shrunken Centroids while Leave-One-Out-CV (LOOCV) was used for the SVM. Independent test data was created to estimate the true error. With "null" and "non null" (with differential expression between the classes) data, we also tested a nested CV procedure, where an inner CV loop is used to perform the tuning of the parameters while an outer CV is used to compute an estimate of the error. The CV error estimate for the classifier with the optimal parameters was found to be a substantially biased estimate of the true error that the classifier would incur on independent data. Even though there is no real difference between the two classes for the "null" datasets, the CV error estimate for the Shrunken Centroid with the optimal parameters was less than 30% on 18.5% of simulated training data-sets. For SVM with optimal parameters the estimated error rate was less than 30% on 38% of "null" data-sets. Performance of the optimized classifiers on the independent test set was no better than chance. The nested CV procedure reduces the bias considerably and gives an estimate of the error that is very close to that obtained on the independent testing set for both Shrunken Centroids and SVM classifiers for "null" and "non-null" data distributions. We show that using CV to compute an error estimate for a classifier that has itself been tuned using CV gives a significantly biased estimate of the true error. Proper use of CV for estimating true error of a classifier developed using a well defined algorithm requires that all steps of the algorithm, including classifier parameter tuning, be repeated in each CV loop. A nested CV procedure provides an almost unbiased estimate of the true error. JF - BMC Bioinformatics AU - Varma, Sudhir AU - Simon, Richard AD - Biometric Research Branch, National Cancer Institute, Bethesda MD, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 91 KW - Algorithms KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Bias+in+error+estimation+when+using+cross-validation+for+model+selection&rft.au=Varma%2C+Sudhir%3BSimon%2C+Richard&rft.aulast=Varma&rft.aufirst=Sudhir&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-91 L2 - http://www.biomedcentral.com/1471-2105/7/91 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Algorithms; Bioinformatics; Models DO - http://dx.doi.org/10.1186/1471-2105-7-91 ER - TY - JOUR T1 - Gene functional similarity search tool (GFSST) AN - 19456683; 6991576 AB - With the completion of the genome sequences of human, mouse, and other species and the advent of high throughput functional genomic research technologies such as biomicroarray chips, more and more genes and their products have been discovered and their functions have begun to be understood. Increasing amounts of data about genes, gene products and their functions have been stored in databases. To facilitate selection of candidate genes for gene-disease research, genetic association studies, biomarker and drug target selection, and animal models of human diseases, it is essential to have search engines that can retrieve genes by their functions from proteome databases. In recent years, the development of Gene Ontology (GO) has established structured, controlled vocabularies describing gene functions, which makes it possible to develop novel tools to search genes by functional similarity. By using a statistical model to measure the functional similarity of genes based on the Gene Ontology directed acyclic graph, we developed a novel Gene Functional Similarity Search Tool (GFSST) to identify genes with related functions from annotated proteome databases. This search engine lets users design their search targets by gene functions. An implementation of GFSST which works on the UniProt (Universal Protein Resource) for the human and mouse proteomes is available at GFSST Web Server. GFSST provides functions not only for similar gene retrieval but also for gene search by one or more GO terms. This represents a powerful new approach for selecting similar genes and gene products from proteome databases according to their functions. JF - BMC Bioinformatics AU - Zhang, Peisen AU - Zhang, Jinghui AU - Sheng, Huitao AU - Russo, James J AU - Osborne, Brian AU - Buetow, Kenneth AD - Laboratory of Population Genetics, National Cancer Institute, NIH, Bethesda, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 135 KW - Genomes KW - Databases KW - Mathematical models KW - Data processing KW - Animal models KW - Statistical analysis KW - Drug development KW - Bioinformatics KW - genomics KW - biomarkers KW - Drugs KW - W 30960:Bioinformatics & Computer Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Gene+functional+similarity+search+tool+%28GFSST%29&rft.au=Zhang%2C+Peisen%3BZhang%2C+Jinghui%3BSheng%2C+Huitao%3BRusso%2C+James+J%3BOsborne%2C+Brian%3BBuetow%2C+Kenneth&rft.aulast=Zhang&rft.aufirst=Peisen&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-135 L2 - http://www.biomedcentral.com/1471-2105/7/135 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Data processing; Mathematical models; Statistical analysis; Animal models; Drug development; genomics; Bioinformatics; Drugs; biomarkers DO - http://dx.doi.org/10.1186/1471-2105-7-135 ER - TY - JOUR T1 - Rituximab therapy for chronic lymphocytic leukemia-associated autoimmune hemolytic anemia AN - 19454682; 6970378 AB - Autoimmune hemolytic anemia (AIHA) is a well-known complication of chronic lymphocytic leukemia (CLL). In recent years the anti-CD20 monoclonal antibody rituximab has been used for the therapy of steroid-refractory AIHA and autoimmune thrombocytopenia, either idiopathic or in association with CLL. We report the results of rituximab treatment for 14 patients suffering from CLL- associated AIHA. They developed a direct antiglobulin test positive AIHA at a mean time of 47 months (range 0-135 months) from the diagnosis of CLL. In 3 cases AIHA was diagnosed at the same time as CLL. Only 1 patient had fludarabine-related AIHA. All patients received steroids as first-line treatment. At a mean time of 46 days (range 1-210 days) from the diagnosis of AIHA all patients received rituximab at a dosage of 375 mg/m super(2)/weekly for 4 weeks. All patients except 3 (2 died of cardiac failure or sepsis soon after the third cycle and 1 HCV-positive patient experienced a rise in serum amino transferases) completed the scheduled four programmed cycles. First injection side effects of rituximab were minimal. All but 2 patients showed an increase in hemoglobin levels in response to rituximab (mean value 3.6 g/dl; range 0.7-10 g/dl) and a reduction in the absolute lymphocyte count and lymph nodes and spleen volume. Nine patients required packed red cell transfusions before starting rituximab; 5 no longer needed transfusions just after the second cycle and another patient after the fourth cycle. Three patients (22%) were considered to fully respond and 7 (50%) only responded partially. At a mean follow-up of 17 months, 8 patients were still alive, 6 of them transfusion-free. Our results prove that the anti-CD20 monoclonal antibody is an effective and well-tolerated alternative treatment for CLL-associated AIHA. Am. J. Hematol. 81:598-602, 2006. JF - American Journal of Hematology AU - D'Arena, Giovanni AU - Laurenti, Luca AU - Capalbo, Silvana AU - D'Arco, Alfonso Maria AU - De Filippi, Rosaria AU - Marcacci, Gianpaolo AU - Di Renzo, Nicola AU - Storti, Sergio AU - Califano, Catello AU - Vigliotti, Maria Luigia AU - Tarnani, Michela AU - Ferrara, Felicetto AU - Pinto, Antonio AD - Hematology and Bone Marrow Transplantation Unit, National Cancer Institute, IRCCS Fondazione "G. Pascale," Naples, Italy, giovannidarena@libero.it Y1 - 2006 PY - 2006 DA - 2006 SP - 598 EP - 602 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 81 IS - 8 SN - 0361-8609, 0361-8609 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - chronic lymphocytic leukemia KW - autoimmune hemolytic anemia KW - rituximab KW - Heart KW - Autoimmune hemolytic anemia KW - Cell number KW - Monoclonal antibodies KW - Spleen KW - Steroid hormones KW - Lymphocytes KW - Transfusion KW - Lymph nodes KW - Coombs' test KW - Hemoglobin KW - Sepsis KW - Thrombocytopenia KW - Chronic lymphatic leukemia KW - Side effects KW - J 02400:Human Diseases KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Hematology&rft.atitle=Rituximab+therapy+for+chronic+lymphocytic+leukemia-associated+autoimmune+hemolytic+anemia&rft.au=D%27Arena%2C+Giovanni%3BLaurenti%2C+Luca%3BCapalbo%2C+Silvana%3BD%27Arco%2C+Alfonso+Maria%3BDe+Filippi%2C+Rosaria%3BMarcacci%2C+Gianpaolo%3BDi+Renzo%2C+Nicola%3BStorti%2C+Sergio%3BCalifano%2C+Catello%3BVigliotti%2C+Maria+Luigia%3BTarnani%2C+Michela%3BFerrara%2C+Felicetto%3BPinto%2C+Antonio&rft.aulast=D%27Arena&rft.aufirst=Giovanni&rft.date=2006-01-01&rft.volume=81&rft.issue=8&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Hematology&rft.issn=03618609&rft_id=info:doi/10.1002%2Fajh.20665 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Autoimmune hemolytic anemia; Cell number; Monoclonal antibodies; Spleen; Lymphocytes; Steroid hormones; Transfusion; Lymph nodes; Hemoglobin; Coombs' test; Sepsis; Thrombocytopenia; rituximab; Chronic lymphatic leukemia; Side effects DO - http://dx.doi.org/10.1002/ajh.20665 ER - TY - JOUR T1 - Noninvasive quantification of cerebral blood volume in humans during functional activation AN - 19448809; 6730972 AB - Like cerebral blood flow (CBF), cerebral blood volume (CBV) is an important physiological parameter closely associated with brain activity and thus, noninvasive quantification of CBV during brain activation provides another opportunity to investigate the relationship between neuronal activity and hemodynamic changes. In this paper, a new method is presented that is able to quantify CBV at rest and during activation. Specifically, using an inversion recovery pulse sequence, a set of brain images was collected at various inversion times (TIs). At each TI, functional images were acquired with a block- design visual stimulation paradigm. A biophysical model comprised of multiple tissue components was developed and was utilized for the determination of CBV using the visual stimulation data. MRI experiments on five healthy volunteers showed that CBV was 5.0 +/- 1.5 ml blood/100 ml brain during rest and increased to 6.6 +/- 1.8 ml blood/100 ml brain following visual stimulation. Furthermore, experiments with visual stimulation at two frequencies (2 and 8 Hz) showed that the increases in CBV correlated with the strength of stimulation. This technique, with its ability to measure quantitative CBV values noninvasively, provides a valuable tool for quantifying hemodynamic signals associated with brain activation. JF - NeuroImage AU - Gu, Hong AU - Lu, Hanzhang AU - Ye, Frank Q AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr., Building C, Room 383, Baltimore, MD 21042, USA, yihongyang@intra.nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 377 EP - 387 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Brain KW - Hemodynamics KW - Visual stimuli KW - Inversion KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19448809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Noninvasive+quantification+of+cerebral+blood+volume+in+humans+during+functional+activation&rft.au=Gu%2C+Hong%3BLu%2C+Hanzhang%3BYe%2C+Frank+Q%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Gu&rft.aufirst=Hong&rft.date=2006-01-01&rft.volume=30&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.09.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Visual stimuli; Hemodynamics; Cerebral blood flow; Inversion; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2005.09.057 ER - TY - JOUR T1 - Measurement of naproxen in human plasma by chip-based immunoaffinity capillary electrophoresis AN - 19448799; 6902918 AB - An electrokinetic immunoassay performed in a chip-based capillary electrophoresis system is described for the rapid measurement of naproxen in human plasma. The system employs a fluorescently labeled antibody to capture and detect the analyte of interest within a 5 min total assay time with an LOD of 0.025 mu g/mL and a saturation level of 450 mu g/mL. The system compared well with a conventional HPLC technique but was found to be much faster. Application of the electrokinetic assay to the study of patients with allergy to naproxen demonstrated increased concentrations of the drug extending past the predicted elimination half-life. The portability of the system and its ability to process up to 18 samples per hour makes it suitable for use in emergency room situations. JF - Biomedical Chromatography AU - Phillips, Terry M AU - Wellner, Edward F AD - Ultramicro Analytical Immunochemistry Resource, Division of Bioengineering and Physical Science, Office of Research Services, National Institutes of Health, Bethesda MD, USA, phillipt@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 662 EP - 667 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 20 IS - 6-7 SN - 0269-3879, 0269-3879 KW - Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - naproxen KW - Hypersensitivity KW - Antibodies KW - Chromatography KW - capillary electrophoresis KW - Immunoassays KW - Drugs KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19448799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Chromatography&rft.atitle=Measurement+of+naproxen+in+human+plasma+by+chip-based+immunoaffinity+capillary+electrophoresis&rft.au=Phillips%2C+Terry+M%3BWellner%2C+Edward+F&rft.aulast=Phillips&rft.aufirst=Terry&rft.date=2006-01-01&rft.volume=20&rft.issue=6-7&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Biomedical+Chromatography&rft.issn=02693879&rft_id=info:doi/10.1002%2Fbmc.673 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - naproxen; capillary electrophoresis; Antibodies; Chromatography; Hypersensitivity; High-performance liquid chromatography; Drugs; Immunoassays DO - http://dx.doi.org/10.1002/bmc.673 ER - TY - JOUR T1 - Cortical abnormalities in bipolar disorder investigated with MRI and voxel- based morphometry AN - 19448607; 6730982 AB - Bipolar disorder (BD) has been associated with abnormalities of brain structure. Specifically, in vivo volumetric MRI and/or post mortem studies of BD have reported abnormalities of gray matter (GM) volume in the medial prefrontal cortex (PFC), amygdala, hippocampal subiculum and ventral striatum. These structures share anatomical connections with each other and form part of a "visceromotor" network modulating emotional behavior. Areas of the lateral orbital, superior temporal and posterior cingulate cortices project to this network, but morphometric abnormalities in these areas have not been established in BD. The current study assessed tissue volumes within these areas in BD using MRI and voxel-based morphometry (VBM). MRI images were obtained from 36 BD subjects and 65 healthy controls. To account for possible neurotrophic and neuroprotective effects of psychotropic medications, BD subjects were divided into medicated and unmedicated groups. Images were segmented into tissue compartments, which were examined on a voxel-wise basis to determine the location and extent of morphometric changes. The GM was reduced in the posterior cingulate/retrosplenial cortex and superior temporal gyrus of unmedicated BD subjects relative to medicated BD subjects and in the lateral orbital cortex of medicated BD subjects relative to controls. White matter (WM) was increased in the orbital and posterior cingulate cortices, which most likely reflected alterations in gyral morphology resulting from the reductions in the associated GM. The morphometric abnormalities in the posterior cingulate, superior temporal and lateral orbital cortices in BD support the hypothesis that the extended network of neuroanatomical structures subserving visceromotor regulation contains structural alterations in BD. Additionally, localization of morphometric abnormalities to areas known to exhibit increased metabolism in depression supports the hypothesis that repeated stress and elevated glucocorticoid secretion may result in neuroplastic changes in BD. JF - NeuroImage AU - Nugent, Allison C AU - Milham, Michael P AU - Bain, Earle E AU - Mah, Linda AU - Cannon, Dara M AU - Marrett, Sean AU - Zarate, Carlos A AU - Pine, Daniel S AU - Price, Joseph L AU - Drevets, Wayne C AD - Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892-0135, USA, nugenta@intra.nimh.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 485 EP - 497 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Hippocampus KW - superior temporal gyrus KW - Secretion KW - Magnetic resonance imaging KW - Substantia alba KW - Neuroprotection KW - Cortex (temporal) KW - Anatomy KW - Cortex KW - Neostriatum KW - Brain architecture KW - Depression KW - Emotional behavior KW - Brain KW - Stress KW - Glucocorticoids KW - Cortex (cingulate) KW - Bipolar disorder KW - Morphometry KW - Amygdala KW - Metabolism KW - Cortex (prefrontal) KW - Substantia grisea KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19448607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Cortical+abnormalities+in+bipolar+disorder+investigated+with+MRI+and+voxel-+based+morphometry&rft.au=Nugent%2C+Allison+C%3BMilham%2C+Michael+P%3BBain%2C+Earle+E%3BMah%2C+Linda%3BCannon%2C+Dara+M%3BMarrett%2C+Sean%3BZarate%2C+Carlos+A%3BPine%2C+Daniel+S%3BPrice%2C+Joseph+L%3BDrevets%2C+Wayne+C&rft.aulast=Nugent&rft.aufirst=Allison&rft.date=2006-01-01&rft.volume=30&rft.issue=2&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.09.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Cortex (temporal); Cortex (cingulate); Morphometry; Bipolar disorder; Cortex; Brain architecture; Stress; Substantia alba; Emotional behavior; Neostriatum; Glucocorticoids; Cortex (prefrontal); superior temporal gyrus; Secretion; Amygdala; Neuroprotection; Metabolism; Hippocampus; Brain; Anatomy; Depression; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2005.09.029 ER - TY - JOUR T1 - Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations AN - 19448537; 6730865 AB - Membranes obtained from cell lines that express or do not express a target membrane bound protein have been immobilized on a silica-based liquid chromatographic support or on the surface of an activated glass capillary. The resulting chromatographic columns have been placed in liquid chromatographic systems and used to characterize the target proteins and to identify small molecules that bind to the target. Membranes containing ligand gated ion channels, G-protein coupled receptors and drug transporters have been prepared and characterized. If a marker ligand has been identified for the target protein, frontal or zonal displacement chromatographic techniques can be used to determine binding affinities (K sub(d) values) and non-linear chromatography can be used to assess the association (k sub(on)) and dissociation (k sub(off)) rate constants and the thermodynamics of the binding process. Membrane-based affinity columns have been created using membranes from a cell line that does not express the target protein (control) and the same cell line that expresses the target protein (experimental) after genomic transfection. The resulting columns can be placed in a parallel chromatography system and the differential retention between the control and experimental columns can be used to identify small molecules and protein that bind to the target protein. These applications will be illustrated using columns created using cellular membranes containing nicotinic acetylcholine receptors and the drug transporter P- glycoprotein. JF - Analytica Chimica Acta AU - Moaddel, Ruin AU - Wainer, Irving W AD - Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA, Wainerir@grc.nia.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 97 EP - 105 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 564 IS - 1 SN - 0003-2670, 0003-2670 KW - Biotechnology and Bioengineering Abstracts KW - Thermodynamics KW - G protein-coupled receptors KW - Transfection KW - Chromatography KW - Ion channels KW - Glycoproteins KW - genomics KW - Drugs KW - Acetylcholine receptors (nicotinic) KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19448537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Development+of+immobilized+membrane-based+affinity+columns+for+use+in+the+online+characterization+of+membrane+bound+proteins+and+for+targeted+affinity+isolations&rft.au=Moaddel%2C+Ruin%3BWainer%2C+Irving+W&rft.aulast=Moaddel&rft.aufirst=Ruin&rft.date=2006-01-01&rft.volume=564&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2005.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chromatography; Drugs; Ion channels; genomics; Transfection; G protein-coupled receptors; Acetylcholine receptors (nicotinic); Thermodynamics; Glycoproteins DO - http://dx.doi.org/10.1016/j.aca.2005.09.020 ER - TY - JOUR T1 - Phase analysis of circadian-related genes in two tissues AN - 19445326; 6801706 AB - Recent circadian clock studies using gene expression microarray in two different tissues of mouse have revealed not all circadian-related genes are synchronized in phase or peak expression times across tissues in vivo. Instead, some circadian-related genes may be delayed by 4-8 hrs in peak expression in one tissue relative to the other. These interesting biological observations prompt a statistical question regarding how to distinguish the synchronized genes from genes that are systematically lagged in phase/peak expression time across two tissues. We propose a set of techniques from circular statistics to analyze phase angles of circadian-related genes in two tissues. We first estimate the phases of a cycling gene separately in each tissue, which are then used to estimate the paired angular difference of the phase angles of the gene in the two tissues. These differences are modeled as a mixture of two von Mises distributions which enables us to cluster genes into two groups; one group having synchronized transcripts with the same phase in the two tissues, the other containing transcripts with a discrepancy in phase between the two tissues. For each cluster of genes we assess the association of phases across the tissue types using circular-circular regression. We also develop a bootstrap methodology based on a circular-circular regression model to evaluate the improvement in fit provided by allowing two components versus a one-component von-Mises model. We applied our proposed methodologies to the circadian-related genes common to heart and liver tissues in Storch et al. [2], and found that an estimated 80% of circadian-related transcripts common to heart and liver tissues were synchronized in phase, and the other 20% of transcripts were lagged about 8 hours in liver relative to heart. The bootstrap p-value for being one cluster is 0.063, which suggests the possibility of two clusters. Our methodologies can be extended to analyze peak expression times of circadian- related genes across more than two tissues, for example, kidney, heart, liver, and the suprachiasmatic nuclei (SCN) of the hypothalamus. JF - BMC Bioinformatics AU - Liu, Delong AU - Peddada, Shyamal D AU - Li, Leping AU - Weinberg, Clarice R AD - Biostatistics Branch, National Institute of Environmental Health Sciences, MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Article No. 87 KW - Heart KW - Statistics KW - Liver KW - Regression analysis KW - Kidney KW - Circadian rhythms KW - Statistical analysis KW - Bioinformatics KW - Nuclei KW - DNA microarrays KW - Models KW - G 07870:Mammals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19445326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Phase+analysis+of+circadian-related+genes+in+two+tissues&rft.au=Liu%2C+Delong%3BPeddada%2C+Shyamal+D%3BLi%2C+Leping%3BWeinberg%2C+Clarice+R&rft.aulast=Liu&rft.aufirst=Delong&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-87 L2 - http://www.biomedcentral.com/1471-2105/7/87 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Statistics; Statistical analysis; Circadian rhythms; Kidney; Regression analysis; Liver; Bioinformatics; Nuclei; DNA microarrays; Models DO - http://dx.doi.org/10.1186/1471-2105-7-87 ER - TY - JOUR T1 - Specific DNA binding by the homeodomain Nkx2.5(C56S): Detection of impaired DNA or unfolded protein by isothermal titration calorimetry AN - 19442150; 6837786 AB - Titrations of specific 18-bp duplex DNA with the cardiac-specific homeodomain Nkx2.5(C56S) have utilized an ultrasensitive isothermal titration calorimeter (ITC). As the free DNA nears depletion, we observe large apparent decreases in the binding enthalpy when the DNA is impaired or when the temperature is sufficiently high to produce some unfolding of the free protein. Either effect can be attributed to refolding of the biopolymer that occurs as a result of stabilization due to the large favorable change in free energy on the homeodomain binding to DNA (-49.4 kJ/mol at 298 K). In either case, thermodynamic parameters obtained in such ITC experiments are unreliable. By using a lower temperature (85 vs. 95 degree C) during the annealing of complementary DNA strands, damage of the 18-bp duplex DNA (T sub(m) = 72 degree C) is avoided, and titrations with the homeodomain are normal at temperatures from 10 to 40 degree C when >95% of the protein is folded. Under the latter conditions, the heat capacity plot is linear with a [Delta]C sub(p) value of -0.80 +/- 0.03 kJ K super(-1) mol super(-1), which is more negative than that calculated from the burial of solvent accessible surface areas (-0.64 +/- 0.05 kJ K super(-1) mol super(-1)), consistent with water structures being at the protein-DNA interfaces. Proteins 2006. JF - Proteins: Structure, Function & Bioinformatics AU - Fodor, Elfrieda AU - Ginsburg, Ann AD - Section on Protein Chemistry, Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, ginsbura@nhlbi.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 13 EP - 18 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 64 IS - 1 SN - 0887-3585, 0887-3585 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - homeodomain KW - protein KW - duplex DNA stability KW - heat capacity change KW - Temperature effects KW - Enthalpy KW - Thermodynamics KW - Surface area KW - Biopolymers KW - Solvents KW - Homeobox KW - Free energy KW - Protein structure KW - DNA damage KW - Protein folding KW - Heat KW - Titration KW - DNA KW - Calorimetry KW - Bioinformatics KW - N 14835:Protein-Nucleic Acids Association KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=Specific+DNA+binding+by+the+homeodomain+Nkx2.5%28C56S%29%3A+Detection+of+impaired+DNA+or+unfolded+protein+by+isothermal+titration+calorimetry&rft.au=Fodor%2C+Elfrieda%3BGinsburg%2C+Ann&rft.aulast=Fodor&rft.aufirst=Elfrieda&rft.date=2006-01-01&rft.volume=64&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Enthalpy; Thermodynamics; Surface area; Solvents; Biopolymers; Homeobox; Free energy; Protein structure; DNA damage; Protein folding; Heat; Titration; DNA; Calorimetry; Bioinformatics DO - http://dx.doi.org/10.1002/prot.20960 ER - TY - JOUR T1 - Influence of the zinc concentration of sol-gel derived zinc substituted hydroxyapatite on cytokine production by human monocytes in vitro AN - 19441021; 6816560 AB - A possible complication associated with the implantation of hydroxyapatite (HA)-based prosthesis is the release of particles. These particles can be phagocyted by monocytes that are among the first cells to colonize the inflammatory site. The activated monocytes produce inflammatory mediators such as cytokines that cause osteoclasts activation. The present work, describes studies on the effect of sol-gel derived zinc-substituted HA particles with various zinc substitution percentages (0.5-2%) on cytokine production (TNF- alpha , IL-1 beta , IL-6, IL-10, and IL-8) by both LPS-stimulated or unstimulated human monocytes. Our data demonstrates that the zinc has an effect on cytokines production. It decreases the production of TNF- alpha and increases the production of IL-8 by unstimulated cells. Using LPS-stimulated cells, it decreases the production of inflammatory cytokines and increases the production of anti-inflammatory cytokine (IL-10), indicating that zinc-substituted hydroxyapatite has favourable effects on the cytokines production by monocytes. JF - Biomaterials AU - Grandjean-Laquerriere, Alexia AU - Laquerriere, Patrice AU - Jallot, Edouard AU - Nedelec, Jean-Marie AU - Guenounou, Moncef AU - Laurent-Maquin, Dominique AU - Phillips, Terry M AD - Ultramicro Analytical Immunochemistry Resource, Division of Bioengineering & Physical Science, Office of Research Services, National Institutes of Health, Bethesda, MD 20892, USA, patrice.laquerriere@univ-reims.fr Y1 - 2006 PY - 2006 DA - 2006 SP - 3195 EP - 3200 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 27 IS - 17 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Interleukin 6 KW - Osteoclasts KW - Interleukin 1 KW - Interleukin 10 KW - Interleukin 8 KW - Cell activation KW - Inflammation KW - Hydroxyapatite KW - Zinc KW - Biomaterials KW - Tumor necrosis factor-^a KW - Cytokines KW - Monocytes KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19441021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Influence+of+the+zinc+concentration+of+sol-gel+derived+zinc+substituted+hydroxyapatite+on+cytokine+production+by+human+monocytes+in+vitro&rft.au=Grandjean-Laquerriere%2C+Alexia%3BLaquerriere%2C+Patrice%3BJallot%2C+Edouard%3BNedelec%2C+Jean-Marie%3BGuenounou%2C+Moncef%3BLaurent-Maquin%2C+Dominique%3BPhillips%2C+Terry+M&rft.aulast=Grandjean-Laquerriere&rft.aufirst=Alexia&rft.date=2006-01-01&rft.volume=27&rft.issue=17&rft.spage=3195&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2006.01.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monocytes; Zinc; Hydroxyapatite; Inflammation; Interleukin 8; Interleukin 10; Osteoclasts; Tumor necrosis factor-^a; Interleukin 6; Cytokines; Interleukin 1; Biomaterials; Cell activation DO - http://dx.doi.org/10.1016/j.biomaterials.2006.01.024 ER - TY - JOUR T1 - Systematic intervention of transcription for identifying network response to disease and cellular phenotypes AN - 19439113; 6666392 AB - MOTIVATION: A major challenge in post-genomic research has been to understand how physiological and pathological phenotypes arise from the networks of expressed genes. Here, we addressed this issue by developing an algorithm to mimic the behavior of regulatory networks in silico and to identify the dynamic response to disease and changing cellular conditions. RESULTS: With regulatory pathway and gene expression data as input, the algorithm provides quantitative assessments of a wide range of responses, including susceptibility to disease, potential usefulness of a given drug, or consequences to such external stimuli as pharmacological interventions or caloric restriction. The algorithm is particularly amenable to the analysis of systems that are difficult to recapitulate in vitro, yet they may have important clinical value. The hypotheses derived from the algorithm were biologically relevant and were successfully validated via independent experiments, as illustrated here in the analysis of the leukemia-associated BCR-ABL pathway and the insulin/IGF pathway related to longevity. The algorithm correctly identified the leukemia drug target and genes important for longevity, and also provided new insights into our understanding of these two processes. AVAILABILITY: The software package is available upon request to the authors. CONTACT: zhanmiail.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Li, Huai AU - Zhan, Ming AD - Bioinformatics Unit, Branch of Research Resources, National Institute on Aging NIH, Baltimore, MD 21224, USA Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 96 EP - 102 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 1 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Dietary restrictions KW - Abl protein KW - Algorithms KW - Transcription KW - External stimuli KW - Insulin KW - BCR protein KW - Longevity KW - Leukemia KW - Computer programs KW - software KW - Insulin-like growth factors KW - Fusion protein KW - Bioinformatics KW - Drugs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Systematic+intervention+of+transcription+for+identifying+network+response+to+disease+and+cellular+phenotypes&rft.au=Li%2C+Huai%3BZhan%2C+Ming&rft.aulast=Li&rft.aufirst=Huai&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Algorithms; Computer programs; Bioinformatics; Longevity; Drugs; Dietary restrictions; Insulin-like growth factors; Transcription; Leukemia; Fusion protein; BCR protein; External stimuli; Abl protein; software; Insulin ER - TY - JOUR T1 - WindowMasker: window-based masker for sequenced genomes AN - 19438521; 6666395 AB - MOTIVATION: Matches to repetitive sequences are usually undesirable in the output of DNA database searches. Repetitive sequences need not be matched to a query, if they can be masked in the database. RepeatMasker/Maskeraid (RM), currently the most widely used software for DNA sequence masking, is slow and requires a library of repetitive template sequences, such as a manually curated RepBase library, that may not exist for newly sequenced genomes. RESULTS: We have developed a software tool called WindowMasker (WM) that identifies and masks highly repetitive DNA sequences in a genome, using only the sequence of the genome itself. WM is orders of magnitude faster than RM because WM uses a few linear-time scans of the genome sequence, rather than local alignment methods that compare each library sequence with each piece of the genome. We validate WM by comparing BLAST outputs from large sets of queries applied to two versions of the same genome, one masked by WM, and the other masked by RM. Even for genomes such as the human genome, where a good RepBase library is available, searching the database as masked with WM yields more matches that are apparently non-repetitive and fewer matches to repetitive sequences. We show that these results hold for transcribed regions as well. WM also performs well on genomes for which much of the sequence was in draft form at the time of the analysis. AVAILABILITY: WM is included in the NCBI C++ toolkit. The source code for the entire toolkit is available at ftp://ftp.ncbi.nih.gov/toolbox/ncbi_tools++/CURRENT/. Once the toolkit source is unpacked, the instructions for building WindowMasker application in the UNIX environment can be found in file src/app/winmasker/README.build. CONTACT: richaelix.nih.gov Supplementary information: Supplementary data are available at ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/windowmasker/windowmasker_ s uppl.pdf. JF - Bioinformatics AU - Morgulis, Aleksandr AU - Gertz, EMichael AU - Schaeffer, Alejandro A AU - Agarwala, Richa AD - National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services Building 38A, Room 1003N, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 134 EP - 141 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 2 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Computer programs KW - Databases KW - software KW - Data processing KW - Nucleotide sequence KW - Src protein KW - Bioinformatics KW - Repeated DNA sequences KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=WindowMasker%3A+window-based+masker+for+sequenced+genomes&rft.au=Morgulis%2C+Aleksandr%3BGertz%2C+EMichael%3BSchaeffer%2C+Alejandro+A%3BAgarwala%2C+Richa&rft.aulast=Morgulis&rft.aufirst=Aleksandr&rft.date=2006-01-01&rft.volume=22&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Genomes; Nucleotide sequence; Databases; Computer programs; software; Bioinformatics; Data processing; Repeated DNA sequences; Src protein ER - TY - JOUR T1 - Accurate anchoring alignment of divergent sequences AN - 19437887; 6666382 AB - MOTIVATION: Obtaining high quality alignments of divergent homologous sequences for cross-species sequence comparison remains a challenge. RESULTS: We propose a novel pairwise sequence alignment algorithm, ACANA (ACcurate ANchoring Alignment), for aligning biological sequences at both local and global levels. Like many fast heuristic methods, ACANA uses an anchoring strategy. However, unlike others, ACANA uses a Smith-Waterman-like dynamic programming algorithm to recursively identify near-optimal regions as anchors for a global alignment. Performance evaluations using a simulated benchmark dataset and real promoter sequences suggest that ACANA is accurate and consistent, especially for divergent sequences. Specifically, we use a simulated benchmark dataset to show that ACANA has the highest sensitivity to align constrained functional sites compared to BLASTZ, CHAOS and DIALIGN for local alignment and compared to AVID, ClustalW, DIALIGN and LAGAN for global alignment. Applied to 6007 pairs of human-mouse orthologous promoter sequences, ACANA identified the largest number of conserved regions (defined as over 70% identity over 100 bp) compared to AVID, ClustalW, DIALIGN and LAGAN. In addition, the average length of conserved region identified by ACANA was the longest. Thus, we suggest that ACANA is a useful tool for identifying functional elements in cross-species sequence analysis, such as predicting transcription factor binding sites in non-coding DNA. AVAILABILITY: ACANA software and test sequence data are publicly available at http://BioMedEmpire.org/ Supplementary information: Supplementary materials are available at Bioinformatics online. CONTACT: li3iehs.nih.gov JF - Bioinformatics AU - Huang, Weichun AU - Umbach, David M AU - Li, Leping AD - Biostatistics Branch, The National Institute of Environmental Health Sciences RTP, NC 27709 USA. Bioinformatics Research Center, North Carolina State University Raleigh, NC 27606 USA. Institute for Genome Sciences & Policy, Duke University Medical Center Durham, NC 27708 USA Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 29 EP - 34 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 1 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Promoters KW - software KW - Transcription factors KW - Nucleotide sequence KW - DNA KW - Algorithms KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19437887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Accurate+anchoring+alignment+of+divergent+sequences&rft.au=Huang%2C+Weichun%3BUmbach%2C+David+M%3BLi%2C+Leping&rft.aulast=Huang&rft.aufirst=Weichun&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Algorithms; Promoters; Bioinformatics; Nucleotide sequence; software; DNA; Computer programs; Transcription factors ER - TY - JOUR T1 - Transcriptomic response to differentiation induction AN - 19435282; 6799039 AB - Microarrays used for gene expression studies yield large amounts of data. The processing of such data typically leads to lists of differentially-regulated genes. A common terminal data analysis step is to map pathways of potentially interrelated genes. We applied a transcriptomics analysis tool to elucidate the underlying pathways of leukocyte maturation at the genomic level in an established cellular model of leukemia by examining time-course data in two subclones of U-937 cells. Leukemias such as Acute Promyelocytic Leukemia (APL) are characterized by a block in the hematopoietic stem cell maturation program at a point when expansion of clones which should be destined to mature into terminally- differentiated effector cells get locked into endless proliferation with few cells reaching maturation. Treatment with retinoic acid, depending on the precise genomic abnormality, often releases the responsible promyelocytes from this blockade but clinically can yield adverse sequellae in terms of potentially lethal side effects, referred to as retinoic acid syndrome. Briefly, the list of genes for temporal patterns of expression was pasted into the ABCC GRID Promoter TFSite Comparison Page website tool and the outputs for each pattern were examined for possible coordinated regulation by shared regelems (regulatory elements). We found it informative to use this novel web tool for identifying, on a genomic scale, genes regulated by drug treatment. Improvement is needed in understanding the nature of the mutations responsible for controlling the maturation process and how these genes regulate downstream effects if there is to be better targeting of chemical interventions. Expanded implementation of the techniques and results reported here may better direct future efforts to improve treatment for diseases not restricted to APL. JF - BMC Bioinformatics AU - Patton, G W AU - Stephens, R AU - Sidorov, IA AU - Xiao, X AU - Lempicki, R A AU - Dimitrov, D S AU - Shoemaker, R H AU - Tudor, G AD - Screening Technologies Branch, Developmental Therapeutics Program, NCI- Frederick, Frederick, MD 21702, USA Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 IS - 1 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 81 KW - Data processing KW - Retinoic acid KW - Regulatory sequences KW - Leukocytes KW - DNA microarrays KW - Effector cells KW - Gene expression KW - Differentiation KW - Promoters KW - Stem cells KW - Acute promyeloid leukemia KW - Bioinformatics KW - genomics KW - Cell proliferation KW - Mutation KW - Drugs KW - Side effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19435282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Transcriptomic+response+to+differentiation+induction&rft.au=Patton%2C+G+W%3BStephens%2C+R%3BSidorov%2C+IA%3BXiao%2C+X%3BLempicki%2C+R+A%3BDimitrov%2C+D+S%3BShoemaker%2C+R+H%3BTudor%2C+G&rft.aulast=Patton&rft.aufirst=G&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-7-81 L2 - http://www.biomedcentral.com/1471-2105/7/81 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - genomics; Retinoic acid; Data processing; Stem cells; DNA microarrays; Promoters; Side effects; Bioinformatics; Effector cells; Regulatory sequences; Acute promyeloid leukemia; Gene expression; Differentiation; Cell proliferation; Leukocytes; Drugs; Mutation DO - http://dx.doi.org/10.1186/1471-2105-7-81 ER - TY - JOUR T1 - The histone database: A comprehensive resource for histones and histone fold-containing proteins AN - 19430346; 6691217 AB - TheThe Histone Database is a curated and searchable collection of full- length sequences and structures of histones and nonhistone proteins containing histone-like folds, compiled from major public databases. Several new histone fold-containing proteins have been identified, including the huntingtin- interacting protein HYPM. Additionally, based on the recent crystal structure of the Son of Sevenless protein, an interpretation of the sequence analysis of the histone fold domain is presented. The database contains an updated collection of multiple sequence alignments for the four core histones (H2A, H2B, H3, and H4) and the linker histones (H1/H5) from a total of 975 organisms. The database also contains information on the human histone gene complement and provides links to three-dimensional structures of histone and histone fold-containing proteins. The Histone Database is a comprehensive bioinformatics resource for the study of structure and function of histones and histone fold-containing proteins. The database is available at http://research.nhgri.nih.gov/histones/. Proteins 2006. JF - Proteins: Structure, Function & Bioinformatics AU - Marino-Ramirez, Leonardo AU - Hsu, Benjamin AU - Baxevanis, Andreas D AU - Landsman, David AD - Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, landsman@ncbi.nlm.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 838 EP - 842 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 62 IS - 4 SN - 0887-3585, 0887-3585 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - histones KW - histone-like proteins KW - multiple sequence alignments KW - Histone Database KW - Protein structure KW - Databases KW - Son of Sevenless protein KW - Histones KW - Structure-function relationships KW - Nonhistone proteins KW - Nucleotide sequence KW - Crystal structure KW - Bioinformatics KW - Histone H2A KW - Histone H1 KW - N 14820:DNA Metabolism & Structure KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19430346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=The+histone+database%3A+A+comprehensive+resource+for+histones+and+histone+fold-containing+proteins&rft.au=Marino-Ramirez%2C+Leonardo%3BHsu%2C+Benjamin%3BBaxevanis%2C+Andreas+D%3BLandsman%2C+David&rft.aulast=Marino-Ramirez&rft.aufirst=Leonardo&rft.date=2006-01-01&rft.volume=62&rft.issue=4&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20814 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; Databases; Son of Sevenless protein; Histones; Nonhistone proteins; Structure-function relationships; Nucleotide sequence; Crystal structure; Bioinformatics; Histone H2A; Histone H1 DO - http://dx.doi.org/10.1002/prot.20814 ER - TY - JOUR T1 - Development of biosensors for cancer clinical testing AN - 19429413; 6737848 AB - Biosensors are devices that combine a biochemical recognition/binding element (ligand) with a signal conversion unit (transducer). Biosensors are already used for several clinical applications, for example for electrochemical measurement of blood glucose concentrations. Application of biosensors in cancer clinical testing has several potential advantages over other clinical analysis methods including increased assay speed and flexibility, capability for multi- target analyses, automation, reduced costs of diagnostic testing and a potential to bring molecular diagnostic assays to community health care systems and to underserved populations. They have the potential for facilitating Point of Care Testing (POCT), where state-of-the-art molecular analysis is carried out without requiring a state-of-the-art laboratory. However, not many biosensors have been developed for cancer-related testing. One major challenge in harnessing the potential of biosensors is that cancer is a very complex set of diseases. Tumors vary widely in etiology and pathogenesis. Oncologists rely heavily on histological characterization of tumors and a few biomarkers that have demonstrated clinical utility to aid in patient management decisions. New genomic and proteomic molecular tools are being used to profile tumors and produce "molecular signatures." These signatures include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modifications of proteins. These molecular signatures provide new opportunities for utilizing biosensors. Biosensors have enormous potential to deliver the promise of new molecular diagnostic strategies to patients. This article describes some of the basic elements of cancer biology and cancer biomarkers relevant for the development of biosensors for cancer clinical testing, along with the challenges in using this approach. JF - Biosensors and Bioelectronics AU - Rasooly, Avraham AU - Jacobson, James AD - Cancer Diagnosis Program (CDP) of the National Cancer Institute, United States, rasoolya@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1851 EP - 1858 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 21 IS - 10 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Etiology KW - Glucose KW - Automation KW - Tumors KW - biomarkers KW - Cancer KW - Gene expression KW - Biosensors KW - Blood KW - Post-translation KW - epigenetics KW - proteomics KW - genomics KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19429413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Development+of+biosensors+for+cancer+clinical+testing&rft.au=Rasooly%2C+Avraham%3BJacobson%2C+James&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2006-01-01&rft.volume=21&rft.issue=10&rft.spage=1851&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2006.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Biosensors; Cancer; Tumors; biomarkers; Gene expression; Post-translation; genomics; Blood; Glucose; epigenetics; proteomics; Automation; Etiology DO - http://dx.doi.org/10.1016/j.bios.2006.01.003 ER - TY - JOUR T1 - Single subject image analysis using the complex general linear model; An application to functional magnetic resonance imaging with multiple inputs AN - 19429362; 6735431 AB - A linear time invariant model is applied to functional fMRI blood flow data. Based on traditional time series analysis, this model assumes that the fMRI stochastic output sequence can be determined by a constant plus a linear filter (hemodynamic response function) of several fixed deterministic inputs and an error term assumed stationary with zero mean. The input function consists of multiple exponential distributed (time delay between images) visual stimuli consisting of negative and erotic images. No a priori assumptions are made about the hemodynamic response function that, in essence, is calculated at each spatial position from the data. The sampling rate for the experiment is 400 ms in order to allow for filtering out higher frequencies associated with the cardiac rate. Since the statistical analysis is carried out in the Fourier domain, temporal correlation problems associated with inference in the time domain are avoided. This formal model easily lends itself to further development based on previously developed statistical techniques. JF - Computer Methods and Programs in Biomedicine AU - Rio, Daniel E AU - Rawlings, Robert R AU - Woltz, Lawrence A AU - Salloum, Jasmin B AU - Hommer, Daniel W AD - Section of Brain Electrophysiology and Imaging, Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States, drio@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 10 EP - 19 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 82 IS - 1 SN - 0169-2607, 0169-2607 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Visual stimuli KW - Data processing KW - Functional magnetic resonance imaging KW - Heart rate KW - Statistical analysis KW - Hemodynamics KW - Computer applications KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19429362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Single+subject+image+analysis+using+the+complex+general+linear+model%3B+An+application+to+functional+magnetic+resonance+imaging+with+multiple+inputs&rft.au=Rio%2C+Daniel+E%3BRawlings%2C+Robert+R%3BWoltz%2C+Lawrence+A%3BSalloum%2C+Jasmin+B%3BHommer%2C+Daniel+W&rft.aulast=Rio&rft.aufirst=Daniel&rft.date=2006-01-01&rft.volume=82&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2005.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Models; Statistical analysis; Functional magnetic resonance imaging; Hemodynamics; Data processing; Heart rate; Visual stimuli; Computer applications; Filters DO - http://dx.doi.org/10.1016/j.cmpb.2005.12.003 ER - TY - JOUR T1 - Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection AN - 19425004; 6662764 AB - Papillomaviruses (PV) comprise a large family of nonenveloped DNA viruses that include the oncogenic PV types that are the causative agents of human cervical cancer. As is true of many animal DNA viruses, PV are taken into the cell by endocytosis and must escape from the endosomal compartment to the cytoplasm to initiate infection. Here we show that this step depends on the site-specific enzymatic cleavage of the PV minor virion protein L2 at a consensus furin recognition site. Cleavage by furin, a cell-encoded proprotein convertase, is known to be required for endosome escape by many bacterial toxins. However, to our knowledge, furin has not been previously implicated in the viral entry process. This step is potentially a target for PV inhibition. JF - Proceedings of the National Academy of Sciences, USA AU - Richards, Rebecca M AU - Lowy, Douglas R AU - Schiller, John T AU - Day, Patricia M AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1522 EP - 1527 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 5 SN - 0027-8424, 0027-8424 KW - L2 protein KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Virions KW - Endocytosis KW - endosomes KW - Cytoplasm KW - Cervical cancer KW - Papillomavirus KW - Infection KW - DNA viruses KW - Toxins KW - furin KW - Capsid protein KW - V 22032:Viral proteins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Cleavage+of+the+papillomavirus+minor+capsid+protein%2C+L2%2C+at+a+furin+consensus+site+is+necessary+for+infection&rft.au=Richards%2C+Rebecca+M%3BLowy%2C+Douglas+R%3BSchiller%2C+John+T%3BDay%2C+Patricia+M&rft.aulast=Richards&rft.aufirst=Rebecca&rft.date=2006-01-01&rft.volume=103&rft.issue=5&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Endocytosis; endosomes; Cytoplasm; Cervical cancer; Infection; DNA viruses; Toxins; Capsid protein; furin; Papillomavirus ER - TY - JOUR T1 - Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy AN - 19422096; 6684479 AB - Growth factor receptor-bound 2 (Grb2) is a ubiquitously expressed adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. As such, it has been implicated in the oncogenesis of several important human malignancies. In addition to this function, research over the last decade has revealed other fundamental roles for Grb2 in cell motility and angiogenesis-processes that also contribute to tumor growth, invasiveness and metastasis. This functional profile makes Grb2 a high priority target for anti-cancer drug development. Knowledge of Grb2 protein structure, its component Src homology domains and their respective structure-function relationships has facilitated the rapid development of sophisticated drug candidates that can penetrate cells, bind Grb2 with high affinity and potently antagonize Grb2 signaling. These novel compounds offer considerable promise in our growing arsenal of rationally designed anti-cancer therapeutics. JF - Anti-Cancer Drugs AU - Dharmawardana, P G AU - Peruzzi, B AU - Giubellino, A AU - Burke, TR Jr AU - Bottaro, D P AD - Urologic Oncology Branch, CCR, NCI, Bldg 10, CRC 1, West Rm 3961, 10 Center Drive, MSC 1107, Bethesda, MD 20892-1107, USA, dbottaro@helix.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 13 EP - 20 VL - 17 IS - 1 SN - 0959-4973, 0959-4973 KW - Biotechnology and Bioengineering Abstracts KW - Ras protein KW - Cell surface KW - Grb2 protein KW - Invasiveness KW - Drug development KW - Tumors KW - Metastases KW - adaptor proteins KW - Malignancy KW - Structure-function relationships KW - Growth factor receptors KW - Src protein KW - Cell migration KW - Growth factors KW - Drugs KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19422096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-Cancer+Drugs&rft.atitle=Molecular+targeting+of+growth+factor+receptor-bound+2+%28Grb2%29+as+an+anti-cancer+strategy&rft.au=Dharmawardana%2C+P+G%3BPeruzzi%2C+B%3BGiubellino%2C+A%3BBurke%2C+TR+Jr%3BBottaro%2C+D+P&rft.aulast=Dharmawardana&rft.aufirst=P&rft.date=2006-01-01&rft.volume=17&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Anti-Cancer+Drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Grb2 protein; Drug development; Growth factors; Signal transduction; Malignancy; Structure-function relationships; adaptor proteins; Cell surface; Invasiveness; Cell migration; Src protein; Tumors; Metastases; Growth factor receptors; Ras protein; Drugs ER - TY - JOUR T1 - The Influence of External Loads on Movement Precision During Active Shoulder Internal Rotation Movements as Measured by 3 Indices of Accuracy AN - 19314354; 7055320 AB - Using constant, variable, and absolute error to measure movement accuracy might provide a more complete description of joint position sense than any of these values alone. To determine the effect of loaded movements and type of feedback on shoulder joint position sense and movement velocity. Applied study with repeated measures comparing type of feedback and the presence of a load. Twenty healthy subjects (age = 27.2 plus or minus 3.3 years, height = 173.2 plus or minus 18.1 cm, mass = 70.8 plus or minus 14.5 kg) were seated with their arms in a custom shoulder wheel. Subjects internally rotated 27 degree in the plane of the scapula, with either visual feedback provided by a video monitor or proprioceptive feedback provided by prior passive positioning, to a target at 48 degree of external rotation. Subjects performed the internal rotation movements with video feedback and proprioceptive feedback and with and without load (5% of body weight). High-speed motion analysis recorded peak rotational velocity and accuracy. Constant, variable, and absolute error for joint position sense was calculated from the final position. Unloaded movements demonstrated significantly greater variable error than for loaded movements (2.0 plus or minus 0.7 degree and 1.5 plus or minus 0.4 degree , respectively) (P < .05), but there were no differences in constant or absolute error. Peak velocity was greater for movements with proprioceptive feedback (45.6 plus or minus 2.9 degree /s) than visual feedback (39.1 plus or minus 2.1 degree /s) and for unloaded (47.8 plus or minus 3.6 degree /s) than loaded (36.9 plus or minus 1.0 degree /s) movements (P < .05). Shoulder joint position sense demonstrated greater variable error unloaded versus loaded movements. Both visual feedback and additional loads decreased peak rotational velocity. JF - Journal of Athletic Training AU - Brindle, T J AU - Uhl, T L AU - Nitz, A J AU - Shapiro, R AD - Physical Disabilities Branch, National Institutes of Health, Building 10 CRC, Room 1-1469 MCS 1604, Bethesda, MD 20892-1604, USA, tbrindle@cc.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 60 EP - 66 VL - 41 IS - 1 SN - 1062-6050, 1062-6050 KW - Physical Education Index KW - Measurement KW - Athletic training KW - Videotape KW - Height KW - Accuracy KW - Velocity KW - Health KW - Movement KW - Arms KW - Joints KW - Weight KW - Analysis KW - Work load KW - Shoulders KW - Feedback KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19314354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Athletic+Training&rft.atitle=The+Influence+of+External+Loads+on+Movement+Precision+During+Active+Shoulder+Internal+Rotation+Movements+as+Measured+by+3+Indices+of+Accuracy&rft.au=Brindle%2C+T+J%3BUhl%2C+T+L%3BNitz%2C+A+J%3BShapiro%2C+R&rft.aulast=Brindle&rft.aufirst=T&rft.date=2006-01-01&rft.volume=41&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Journal+of+Athletic+Training&rft.issn=10626050&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Videotape; Athletic training; Velocity; Accuracy; Height; Health; Movement; Arms; Joints; Weight; Analysis; Feedback; Shoulders; Work load ER - TY - JOUR T1 - TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C- delta -independent AN - 19299682; 7048357 AB - Engagement of Toll-like receptor (TLR) proteins activates multiple signal transduction pathways. Previous studies demonstrated that TLR2 and TLR4 engagement leads to rapid phosphorylation of the transcription factor STAT1 at serine 727 (Ser-727 STAT1) in murine macrophages. Only TLR4 engagement induced STAT1 phosphorylation at tyrosine 701, although this response was delayed compared with Ser-727 STAT1 phosphorylation. Unlike other cell types, the p38 mitogen-activated protein kinase was necessary, but not sufficient, for TLR-induced phosphorylation of Ser-727 STAT1 in macrophages. We and others had previously shown that Ser-727 STAT1 phosphorylation could be blocked by rottlerin, an inhibitor of protein kinase C- delta (PKC- delta ). Here we report that peritoneal exudate macrophages from PKC- delta -deficient mice can be activated through TLR2 and TLR4 to elicit rapid phosphorylation of Ser-727 STAT1, which was blocked by both rottlerin and the p38 inhibitor SB203580, but not by the pan-PKC inhibitor bisindoylmaleamide. Furthermore, both normal and PKC- delta -deficient macrophages secreted comparable amounts of IL-6, IP-10, and RANTES following TLR engagement. In contrast, IFN- gamma -induced STAT1 serine phosphorylation was independent of both PKC- delta and p38. Overall, these studies demonstrate that a PKC- delta -independent signaling pathway downstream of both TLR2 and TLR4 is necessary for Ser-727 STAT1 phosphorylation in primary murine macrophages. JF - Journal of Endotoxin Research AU - Shoenfelt, J L AU - Fenton, MJ AD - Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Drive, Room 3105, Bethesda, MD 20892-6601, USA, fentonm@niaid.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 231 EP - 240 VL - 12 IS - 4 SN - 0968-0519, 0968-0519 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Protein kinase C KW - Macrophages KW - gamma -Interferon KW - MAP kinase KW - TLR2 protein KW - Tyrosine KW - Phosphorylation KW - Stat1 protein KW - TLR4 protein KW - Toll-like receptors KW - Serine KW - Signal transduction KW - F 06630:Macrophages KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19299682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=TLR2-+and+TLR4-dependent+activation+of+STAT1+serine+phosphorylation+in+murine+macrophages+is+protein+kinase+C-+delta+-independent&rft.au=Shoenfelt%2C+J+L%3BFenton%2C+MJ&rft.aulast=Shoenfelt&rft.aufirst=J&rft.date=2006-01-01&rft.volume=12&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/10.1179%2F096805106X102219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Protein kinase C; gamma -Interferon; MAP kinase; Phosphorylation; Stat1 protein; TLR2 protein; Tyrosine; TLR4 protein; Serine; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1179/096805106X102219 ER - TY - JOUR T1 - Intrauterine environment and breast cancer risk in a population-based case- control study in Poland AN - 19298733; 7035083 AB - High estrogen exposure in utero may increase breast cancer risk later in life. However, studies of the associations between perinatal factors presumed to affect the fetal hormonal environment and breast cancer risk are inconsistent. We used data from a population-based case-control study of 2,386 incident breast cancers and 2,502 controls in Poland to evaluate risks associated with various perinatal characteristics. After adjusting for confounders, we found a significant trend (p = 0.01) of breast cancer risk with birth weight (OR = 1.54, 95% CI 1.08-2.19 for birth weights >4,000 g vs. 6) were at reduced risk (OR = 0.81, 0.61-1.06) when compared with first born subjects. Birth weight was somewhat a stronger risk predictor among subjects whose cancers were diagnosed at 50 years of age or older (OR = 1.84, 1.19-2.85) than among those with cancers diagnosed at younger ages (OR = 1.14, 0.61-2.12). Subjects whose mothers smoked during their pregnancies were at slightly higher risk than those who never smoked (OR = 1.21, 0.99-1.47), but the risk was similar to mothers who only smoked at other times (OR = 1.22, 0.81-1.84). Breast cancer risk was not related to paternal smoking, maternal age, gestational age or twin status. Our results add support to the growing evidence that some perinatal exposures may relate to breast cancer risk. Additional studies are needed to confirm associations and clarify the biologic mechanisms underlying these associations. Published 2006 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Park, Sue Kyung AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Sherman, Mark E AU - McGlynn, Katherine A AU - Peponska, Beata AU - Bardin-Mikoajczak, Alicja AU - Zatonski, Witold AU - Szeszenia-Dabrowska, Neonila AU - Brinton, Louise A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, parksu@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 2136 EP - 2141 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - breast cancer KW - perinatal factors KW - hormones KW - in utero exposures KW - Smoking KW - Prenatal experience KW - Poland KW - Breast cancer KW - birth weight KW - Cancer KW - Pregnancy KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Intrauterine+environment+and+breast+cancer+risk+in+a+population-based+case-+control+study+in+Poland&rft.au=Park%2C+Sue+Kyung%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BSherman%2C+Mark+E%3BMcGlynn%2C+Katherine+A%3BPeponska%2C+Beata%3BBardin-Mikoajczak%2C+Alicja%3BZatonski%2C+Witold%3BSzeszenia-Dabrowska%2C+Neonila%3BBrinton%2C+Louise+A&rft.aulast=Park&rft.aufirst=Sue&rft.date=2006-01-01&rft.volume=119&rft.issue=9&rft.spage=2136&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21974 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoking; Prenatal experience; birth weight; Breast cancer; Cancer; estrogens; Pregnancy; Poland DO - http://dx.doi.org/10.1002/ijc.21974 ER - TY - JOUR T1 - Population distribution of the functional caspase-12 allele AN - 19275422; 7014899 AB - Members of the caspase family can be important for apoptosis or inflammation, but the role of caspase-12 (CASP12 or CSP12) is unclear. Although most humans lack a functional caspase-12, the Csp 12-L variant, previously found only among people of African descent, produces a full-length proenzyme and increases the risk of sepsis. In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations from sub-Saharan Africa and was also present at low frequency among North African, Middle Eastern, and South Asian populations. Published 2006 Wiley-Liss, Inc. JF - Human Mutation AU - Kachapati, Kritika AU - O'Brien, Thomas R AU - Bergeron, Julie AU - Zhang, Mingdong AU - Dean, Michael AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, obrient@exchange.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 975 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 27 IS - 9 SN - 1059-7794, 1059-7794 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - caspase-12 KW - CASP12 KW - infection KW - sepsis KW - Population genetics KW - Sepsis KW - Apoptosis KW - Caspase-12 KW - Gene frequency KW - Proenzymes KW - Inflammation KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19275422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Mutation&rft.atitle=Population+distribution+of+the+functional+caspase-12+allele&rft.au=Kachapati%2C+Kritika%3BO%27Brien%2C+Thomas+R%3BBergeron%2C+Julie%3BZhang%2C+Mingdong%3BDean%2C+Michael&rft.aulast=Kachapati&rft.aufirst=Kritika&rft.date=2006-01-01&rft.volume=27&rft.issue=9&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Human+Mutation&rft.issn=10597794&rft_id=info:doi/10.1002%2Fhumu.9448 L2 - http://www3.interscience.wiley.com/homepages/38515/pdf/919.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Population genetics; Sepsis; Apoptosis; Caspase-12; Gene frequency; Proenzymes; Inflammation DO - http://dx.doi.org/10.1002/humu.9448 ER - TY - JOUR T1 - The Italian surveillance system for occupational cancers: Characteristics, initial results, and future prospects AN - 19275143; 7014573 AB - Background: Occupational cancer monitoring is important for cancer prevention and public health protection. A surveillance system for identifying occupational cancer risks and cancer cases in Italy that are likely to be of occupational origin using information available in the Italian Social Security archives was created and assessed. Persons employed in the private sector, the employing company, its industrial sector, and years of employment are available in these archives. Methods: A method to find known occupational hazards was first tested using a case-control approach. Cases were from six Italian cancer registries (CRs) and controls were sampled from source populations and as "exposure" the economic sector of the employing company was used. The potential of using hospital discharge records as case sources was subsequently assessed: these cover larger populations and are available more quickly than CR case series. Results: In the CR-based study many known occupational cancer risks related to specific industrial sectors were identified. By using cases from hospital discharge records many industries at risk were identified, as well as cases of recent diagnosis likely to be of occupational origin. However, for some industrial sectors (e.g., the chemical industry) the approach was unable to detect any excess risk. Furthermore, information on employees in important areas like agriculture, self-employment, and the public sector is not available in the Social Security archives. Conclusions: This approach appears to be a promising low-cost method for occupational cancer surveillance, at least for some industries, and can be easily implemented in other countries. Am. J. Ind. Med. 2006. JF - American Journal of Industrial Medicine AU - Crosignani, Paolo AU - Massari, Stefania AU - Audisio, Roberto AU - Amendola, Plinio AU - Cavuto, Silvio AU - Scaburri, Alessandra AU - Zambon, Paola AU - Nedoclan, Giovanni AU - Stracci, Fabrizio AU - Pannelli, Franco AU - Vercelli, Marina AU - Miligi, Lucia AU - Imbriani, Marcello AU - Berrino, Franco AD - Environmental Epidemiology and Cancer Registry Unit, National Cancer Institute, Milan, Italy, occam@istitutotumori.mi.it Y1 - 2006 PY - 2006 DA - 2006 SP - 791 EP - 798 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 49 IS - 9 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts; Risk Abstracts KW - occupational cancer KW - surveillance KW - record linkage KW - case-control KW - occupational diseases KW - Economics KW - Italy KW - Cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19275143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+Italian+surveillance+system+for+occupational+cancers%3A+Characteristics%2C+initial+results%2C+and+future+prospects&rft.au=Crosignani%2C+Paolo%3BMassari%2C+Stefania%3BAudisio%2C+Roberto%3BAmendola%2C+Plinio%3BCavuto%2C+Silvio%3BScaburri%2C+Alessandra%3BZambon%2C+Paola%3BNedoclan%2C+Giovanni%3BStracci%2C+Fabrizio%3BPannelli%2C+Franco%3BVercelli%2C+Marina%3BMiligi%2C+Lucia%3BImbriani%2C+Marcello%3BBerrino%2C+Franco&rft.aulast=Crosignani&rft.aufirst=Paolo&rft.date=2006-01-01&rft.volume=49&rft.issue=9&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - occupational diseases; Economics; Cancer; Italy DO - http://dx.doi.org/10.1002/ajim.20356 ER - TY - JOUR T1 - Environmental toxicants and effects on female reproductive function. AN - 1835469553; 18516253 AB - One of the most toxic substances known to humans, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is also highly pervasive in the environment. It is created naturally in volcanic eruptions and forest fires, and anthropogenically in waste incineration, chlorination processes and certain plastics manufacture. From reports of large industrial and other accidents, or from experimental studies, dioxin exposure has been correlated in animal models and/or humans with chloracne of the skin, organ cancers, hepatotoxicity, gonadal and immune changes, pulmonary and other diseases such as diabetes, skewing of the sex ratio, and infertility. We have demonstrated that the aromatic hydrocarbon receptor (AHR) that binds dioxin in tissues is localized in zebrafish, rat and rhesus monkey (Macaca mulatta) ovaries and in rat and human luteinizing granulosa cells (GC) (among other tissues), that labeled dioxin is specifically localized to granulosa cells of the ovarian follicle as observed by autoradiography, and that incubations of GC or ovarian fragments with environmentally relevant concentrations (fM to nM) of dioxin inhibit estradiol secretion significantly. Our experiments show that in human, non-human primate, rat, trout, and zebrafish ovarian tissues, dioxin inhibits estrogen synthesis at some level of the steroid biosynthetic pathway, most likely by inhibiting transcription of mRNAs for or activity of side-chain cleavage (Cyp11a1 gene) and/or aromatase (Cyp19a1 gene) enzymes, or conceivably other steroidogenic enzymes/factors. Such an untoward effect on estrogen synthesis in females exposed to dioxin environmentally may predispose them to defects in aspects of their fertility. JF - Trends in reproductive biology AU - Hutz, R J AU - Carvan, M J AU - Baldridge, M G AU - Conley, L K AU - Heiden, T King AD - Department of Biological Sciences and NIEHS Marine and Freshwater Biomedical Sciences Center and the Great Lakes Wisconsin Aquatic Technology and Environmental Research (WATER) Institute, University of Wisconsin-Milwaukee; the Medical College of Wisconsin; and the Wisconsin National Primate Research Center (WNPRC), USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 1 EP - 11 VL - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835469553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+reproductive+biology&rft.atitle=Environmental+toxicants+and+effects+on+female+reproductive+function.&rft.au=Hutz%2C+R+J%3BCarvan%2C+M+J%3BBaldridge%2C+M+G%3BConley%2C+L+K%3BHeiden%2C+T+King&rft.aulast=Hutz&rft.aufirst=R&rft.date=2006-01-01&rft.volume=2&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Trends+in+reproductive+biology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2009-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation-Induced Changes in Gene Expression Involve Recruitment of Existing Messenger RNAs to and away from Polysomes AN - 17475027; 6660320 AB - Although ionizing radiation has been shown to influence gene transcription, little is known about the effects of radiation on gene translational efficiency. To obtain a genome-wide perspective of the effects of radiation on gene translation, microarray analysis was done on polysome-bound RNA isolated from irradiated human brain tumor cells; to allow for a comparison with the effects of radiation on transcription, microarray analysis was also done using total RNA. The number of genes whose translational activity was modified by radiation was similar to 10-fold greater than those whose transcription was affected. The radiation-induced change in a gene's translational activity was shown to involve the recruitment of existing mRNAs to and away from polysomes. Moreover, the change in a gene's translational activity after irradiation correlated with changes in the level of its corresponding protein. These data suggest that radiation modifies gene expression primarily at the level of translation. In contrast to transcriptional changes, there was considerable overlap in the genes affected at the translational level among brain tumor cell lines and normal astrocytes. Thus, the radiation-induced translational control of a subset of mRNAs seems to be a fundamental component of cellular radioresponse. (Cancer Res 2006; 66(2): 1052-61) JF - Cancer Research AU - Lue, Xing AU - de la Pena, Lorena AU - Barker, Christopher AU - Camphausen, Kevin AU - Tofilon, Philip J AD - Molecular Radiation Therapeutics Branch and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1052 EP - 1061 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 2 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Toxicology Abstracts KW - Polyribosomes KW - Translation KW - Data processing KW - Astrocytes KW - Transcription KW - DNA microarrays KW - Cancer KW - mRNA KW - Brain tumors KW - Gene expression KW - Tumor cell lines KW - Radiation KW - Ionizing radiation KW - X 24210:Radiation & radioactive materials KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17475027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Radiation-Induced+Changes+in+Gene+Expression+Involve+Recruitment+of+Existing+Messenger+RNAs+to+and+away+from+Polysomes&rft.au=Lue%2C+Xing%3Bde+la+Pena%2C+Lorena%3BBarker%2C+Christopher%3BCamphausen%2C+Kevin%3BTofilon%2C+Philip+J&rft.aulast=Lue&rft.aufirst=Xing&rft.date=2006-01-01&rft.volume=66&rft.issue=2&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Polyribosomes; Translation; Data processing; Astrocytes; Transcription; DNA microarrays; Cancer; mRNA; Gene expression; Brain tumors; Tumor cell lines; Radiation; Ionizing radiation ER - TY - JOUR T1 - Two peptide sequences can function cooperatively to facilitate binding and unfolding by ClpA and degradation by ClpAP AN - 17472627; 6662682 AB - Clp/Hsp100 proteins comprise a large family of AAA super(+) ATPases. Some Clp proteins function alone as molecular chaperones, whereas others act in conjunction with peptidases, forming ATP-dependent proteasome-like compartmentalized proteases. Protein degradation by Clp proteases is regulated primarily by substrate recognition by the Clp ATPase component. The ClpA and ClpX ATPases of Escherichia coli generally recognize short amino acid sequences that are located near the N or C terminus of a substrate. However, both ClpAP and ClpXP are able to degrade proteins in which the end containing the recognition signal is fused to GFP such that the signal is in the interior of the primary sequence of the substrate. Here, we tested whether the internal ClpA recognition signal was the sole element required for targeting the substrate to ClpA. The results show that, in the absence of a high-affinity peptide recognition signal at the terminus, two elements are important for recognition of GFP-RepA fusion proteins by ClpA. One element is the natural ClpA recognition signal located at the junction of GFP and RepA in the fusion protein. The second element is the C-terminal peptide of the fusion protein. Together, these two elements facilitate binding and unfolding by ClpA and degradation by ClpAP. The internal site appears to function similarly to Clp adaptor proteins but, in this case, is covalently attached to the polypeptide containing the terminal tag and both the "adaptor" and "substrate" modules are degraded. JF - Proceedings of the National Academy of Sciences, USA AU - Hoskins, Joel R AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 909 EP - 914 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 4 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Clp protein KW - adaptor proteins KW - Adenosinetriphosphatase KW - HSP100 protein KW - Escherichia coli KW - Green fluorescent protein KW - Proteinase KW - Chaperones KW - Fusion protein KW - peptidase KW - Amino acid sequence KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17472627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Two+peptide+sequences+can+function+cooperatively+to+facilitate+binding+and+unfolding+by+ClpA+and+degradation+by+ClpAP&rft.au=Hoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Hoskins&rft.aufirst=Joel&rft.date=2006-01-01&rft.volume=103&rft.issue=4&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clp protein; adaptor proteins; Adenosinetriphosphatase; HSP100 protein; Green fluorescent protein; Chaperones; Proteinase; Fusion protein; peptidase; Amino acid sequence; Escherichia coli ER - TY - JOUR T1 - Establishing Standards for the Characterization of Human Embryonic Stem Cell Lines AN - 17472178; 6665911 AB - As of August 2005, 22 human embryonic stem cell (hESC) lines listed on the National Institutes of Health (NIH) hESC Registry were being distributed to investigators. At a June 2005 meeting of NIH-supported hESC researchers, we proposed that a set of shared standards should be available in order to characterize the cells unambiguously in multiple laboratories. Here, we elaborate such a plan to identify a set of standard methods and to initiate collaborative efforts to validate the standards. The standard assays we propose should be comprehensive enough to ensure that hESC banks can provide a consistent and reliable product for NIH researchers, and inexpensive enough that individual laboratories can afford to use at least some of the methods routinely in their laboratories. We expect that as data accumulate and standards evolve, a core set of tests will become the norm for routine assessment of hESC cultures and that these tests will lay the groundwork for clinical applications of these cells. JF - Stem Cells AU - Loring, Jeanne F AU - Rao, Mahendra S AD - Stem Cell Center, Burnham Institute for Medical Research, La Jolla, California, USA. Gerontology Research Center, Stem Cell Biology Unit/Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 145 EP - 150 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 1 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Stem cells KW - Embryo cells KW - Laboratories KW - Cell culture KW - Clinical applications KW - W3 33235:New cell lines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17472178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Establishing+Standards+for+the+Characterization+of+Human+Embryonic+Stem+Cell+Lines&rft.au=Loring%2C+Jeanne+F%3BRao%2C+Mahendra+S&rft.aulast=Loring&rft.aufirst=Jeanne&rft.date=2006-01-01&rft.volume=24&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stem cells; Embryo cells; Cell culture; Laboratories; Clinical applications ER - TY - JOUR T1 - Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis AN - 17468788; 6662570 AB - PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its progenitors metronidazole and CGI-17341, PA-824 is a prodrug of the nitroimidazole class, requiring bioreductive activation of an aromatic nitro group to exert an antitubercular effect. We have confirmed that resistance to PA-824 (a nitroimidazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole) is most commonly mediated by loss of a specific glucose-6-phosphate dehydrogenase (FGD1) or its deazaflavin cofactor F sub(420), which together provide electrons for the reductive activation of this class of molecules. Although FGD1 and F sub(420) are necessary for sensitivity to these compounds, they are not sufficient and require additional accessory proteins that directly interact with the nitroimidazole. To understand more proximal events in the reductive activation of PA-824, we examined mutants that were wild-type for both FGD1 and F sub(420) and found that, although these mutants had acquired high-level resistance to PA-824 (and another nitroimidazo-oxazine), they retained sensitivity to CGI-17341 (and a related nitroimidazo-oxazole). Microarray-based comparative genome sequencing of these mutants identified lesions in Rv3547, a conserved hypothetical protein with no known function. Complementation with intact Rv3547 fully restored sensitivity to nitroimidazo-oxazines and restored the ability of Mtb to metabolize PA-824. These results suggest that the sensitivity of Mtb to PA-824 and related compounds is mediated by a protein that is highly specific for subtle structural variations in these bicyclic nitroimidazoles. JF - Proceedings of the National Academy of Sciences, USA AU - Manjunatha, Ujjini H AU - Boshoff, Helena AU - Dowd, Cynthia S AU - Zhang, Liang AU - Albert, Thomas J AU - Norton, Jason E AU - Daniels, Lacy AU - Dick, Thomas AU - Pang, Siew Siew AU - Barry, Clifton EIII AD - Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook II, Rockville, MD 20852 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 431 EP - 436 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 2 SN - 0027-8424, 0027-8424 KW - nitroimidazo-oxazine-specific protein KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Metronidazole KW - Stem cells KW - Cofactors KW - prodrugs KW - Glucose-6-phosphate 1-dehydrogenase KW - Nitroimidazole KW - Tuberculosis KW - Aromatics KW - Antibiotic resistance KW - Mycobacterium tuberculosis KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17468788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Identification+of+a+nitroimidazo-oxazine-specific+protein+involved+in+PA-824+resistance+in+Mycobacterium+tuberculosis&rft.au=Manjunatha%2C+Ujjini+H%3BBoshoff%2C+Helena%3BDowd%2C+Cynthia+S%3BZhang%2C+Liang%3BAlbert%2C+Thomas+J%3BNorton%2C+Jason+E%3BDaniels%2C+Lacy%3BDick%2C+Thomas%3BPang%2C+Siew+Siew%3BBarry%2C+Clifton+EIII&rft.aulast=Manjunatha&rft.aufirst=Ujjini&rft.date=2006-01-01&rft.volume=103&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Metronidazole; Stem cells; Cofactors; prodrugs; Glucose-6-phosphate 1-dehydrogenase; Tuberculosis; Nitroimidazole; Antibiotic resistance; Aromatics; Mycobacterium tuberculosis ER - TY - JOUR T1 - Primary Reinforcing Effects of Nicotine Are Triggered from Multiple Regions Both Inside and Outside the Ventral Tegmental Area AN - 17467189; 6664526 AB - Nicotine is thought to be the key substance responsible for tobacco-smoking habits and appears to trigger reinforcement via the ventral tegmental area (VTA). Recently, multiple anatomical substrates for drug reinforcement have been identified in the vicinity of the ventral midbrain. In addition to the posterior portion of the VTA, the central linear nucleus raphe and the supramammillary nucleus of the posterior hypothalamus mediate drug reinforcement. Using intracranial self-administration procedures, we examined whether these regions mediate the reinforcing effects of nicotine. Rats learned to lever press for self-administration of nicotine into the posterior VTA, central linear nucleus, and supramammillary nucleus, suggesting a reinforcing action of nicotine in these regions. The rats did not self-administer nicotine into surrounding regions including the anterior VTA, substantia nigra, the region just dorsal to the posterior VTA, interpeduncular nucleus, or medial mammillary nucleus. The reinforcing effects of nicotine into the three brain regions were further confirmed by a two-lever discrimination procedure, in which rats learned to selectively respond between active and inactive levers. The reinforcing effects of nicotine administration into the posterior VTA, central linear nucleus, and supramammillary nucleus were blocked by coadministration of the nicotine receptor antagonist mecamylamine. The reinforcing effects of nicotine into the posterior VTA or central linear nucleus were attenuated by coadministration of the D sub(2) receptor agonist quinpirole. These findings demonstrate that nicotine reinforcement involves multiple regions both inside and outside the VTA. JF - Journal of Neuroscience AU - Ikemoto, Satoshi AU - Qin, Mei AU - Liu, Zhong-Hua AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 723 EP - 730 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 3 SN - 0270-6474, 0270-6474 KW - rats KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Dopamine D2 receptors KW - Intracranial self-stimulation KW - Hypothalamus KW - Nicotine KW - mecamylamine KW - Ventral tegmentum KW - Intracranial reinforcement KW - Drug self-administration KW - Y 25807:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Primary+Reinforcing+Effects+of+Nicotine+Are+Triggered+from+Multiple+Regions+Both+Inside+and+Outside+the+Ventral+Tegmental+Area&rft.au=Ikemoto%2C+Satoshi%3BQin%2C+Mei%3BLiu%2C+Zhong-Hua&rft.aulast=Ikemoto&rft.aufirst=Satoshi&rft.date=2006-01-01&rft.volume=26&rft.issue=3&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Intracranial self-stimulation; Hypothalamus; mecamylamine; Nicotine; Ventral tegmentum; Drug self-administration; Intracranial reinforcement ER - TY - JOUR T1 - Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis AN - 17467103; 6661556 AB - The anthrax toxin is composed of three independent polypeptide chains. Successful intoxication only occurs when heptamerization of the receptor-binding polypeptide, the protective antigen (PA), allows binding of the two enzymatic subunits before endocytosis. We show that this tailored behavior is caused by two counteracting posttranslational modifications in the cytoplasmic tail of PA receptors. The receptor is palmitoylated, and this unexpectedly prevents its association with lipid rafts and, thus, its premature ubiquitination. This second modification, which is mediated by the E3 ubiquitin ligase Cbl, only occurs in rafts and is required for rapid endocytosis of the receptor. As a consequence, cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin because of a lower number of surface receptors as well as premature internalization of PA without a requirement for heptamerization. JF - Journal of Cell Biology AU - Abrami, Laurence AU - Leppla, Stephen H AU - van der Goot, FGisou AD - Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland. Microbial Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 309 EP - 320 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 172 IS - 2 SN - 0021-9525, 0021-9525 KW - protective antigen receptors KW - Toxicology Abstracts; Genetics Abstracts KW - Intoxication KW - Endocytosis KW - ubiquitination KW - palmitoylation KW - protective antigen KW - Anthrax KW - Cbl protein KW - Toxins KW - Protein interaction KW - Ubiquitin-protein ligase KW - Lipid rafts KW - X 24370:Natural Toxins KW - G 07320:Bacterial genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17467103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Biology&rft.atitle=Receptor+palmitoylation+and+ubiquitination+regulate+anthrax+toxin+endocytosis&rft.au=Abrami%2C+Laurence%3BLeppla%2C+Stephen+H%3Bvan+der+Goot%2C+FGisou&rft.aulast=Abrami&rft.aufirst=Laurence&rft.date=2006-01-01&rft.volume=172&rft.issue=2&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Intoxication; ubiquitination; Endocytosis; palmitoylation; protective antigen; Anthrax; Cbl protein; Protein interaction; Toxins; Lipid rafts; Ubiquitin-protein ligase ER - TY - JOUR T1 - Compatibility of Gd-DTPA perfusion and histologic studies of the brain AN - 17466373; 6667532 AB - Histology, including immunohistochemistry, and magnetic resonance imaging microscopy ( mu MRI) are complementary techniques for the analysis of brain structure. Therefore, mu MRI analysis, often of formalin-fixed tissue, precedes histologic evaluation of the same experimental animal in many studies. However, the application of gadopentetate dimeglumine (Gd-DTPA), while of value for MRI studies, has an unknown effect on subsequent histology. We demonstrate here that for the mouse brain, histology with Nissl staining and immunostaining for microtubule-associated protein 2, using standard techniques for tissue preparation, are unaffected by prior perfusion of the tissue with Gd-DTPA. This conclusion was based on qualitative morphologic comparisons of stained sections, as well as quantification of mean immunofluorescence pixel intensities from Gd-treated (mean+/-S.D.=131.2+/-28.4; n=3) as compared to nontreated specimens (116.2+/-34.7; n=3, P=.7). Therefore, Gd-DTPA may be applied as a mu MRI contrast agent in formalin-fixed brain tissue prior to histologic studies. JF - Magnetic Resonance Imaging AU - Spencer, Richard G AU - Fishbein, Kenneth W AU - Cheng, Aiwu AU - Mattson, Mark P AD - Nuclear Magnetic Resonance Unit, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA, spencer@helix.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 27 EP - 31 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 24 IS - 1 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Gadopentetate dimeglumine KW - Perfusion KW - Microtubule-associated protein 2 KW - Magnetic resonance imaging KW - Brain KW - Immunofluorescence KW - Microscopy KW - Contrast media KW - Immunohistochemistry KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews KW - N3 11035:Central nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17466373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Compatibility+of+Gd-DTPA+perfusion+and+histologic+studies+of+the+brain&rft.au=Spencer%2C+Richard+G%3BFishbein%2C+Kenneth+W%3BCheng%2C+Aiwu%3BMattson%2C+Mark+P&rft.aulast=Spencer&rft.aufirst=Richard&rft.date=2006-01-01&rft.volume=24&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2005.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Magnetic resonance imaging; Perfusion; Microtubule-associated protein 2; Gadopentetate dimeglumine; Microscopy; Immunofluorescence; Contrast media; Immunohistochemistry DO - http://dx.doi.org/10.1016/j.mri.2005.10.017 ER - TY - JOUR T1 - Functional Dissection of a Neuronal Network Required for Cuticle Tanning and Wing Expansion in Drosophila AN - 17463599; 6664502 AB - A subset of Drosophila neurons that expresses crustacean cardioactive peptide (CCAP) has been shown previously to make the hormone bursicon, which is required for cuticle tanning and wing expansion after eclosion. Here we present evidence that CCAP-expressing neurons (N sub(CCAP)) consist of two functionally distinct groups, one of which releases bursicon into the hemolymph and the other of which regulates its release. The first group, which we call N sub(CCAP)-c929, includes 14 bursicon-expressing neurons of the abdominal ganglion that lie within the expression pattern of the enhancer-trap line c929-Gal4. We show that suppression of activity within this group blocks bursicon release into the hemolymph together with tanning and wing expansion. The second group, which we call N sub(CCAP)-R, consists of N sub(CCAP) neurons outside the c929-Gal4 pattern. Because suppression of synaptic transmission and protein kinase A (PKA) activity throughout N sub(CCAP), but not in N sub(CCAP)-c929, also blocks tanning and wing expansion, we conclude that neurotransmission and PKA are required in N sub(CCAP)-R to regulate bursicon secretion from N sub(CCAP)-c929. Enhancement of electrical activity in N sub(CCAP)-R by expression of the bacterial sodium channel NaChBac also blocks tanning and wing expansion and leads to depletion of bursicon from central processes. NaChBac expression in N sub(CCAP)-c929 is without effect, suggesting that the abdominal bursicon-secreting neurons are likely to be silent until stimulated to release the hormone. Our results suggest that N sub(CCAP) form an interacting neuronal network responsible for the regulation and release of bursicon and suggest a model in which PKA-mediated stimulation of inputs to normally quiescent bursicon-expressing neurons activates release of the hormone. JF - Journal of Neuroscience AU - Luan, Haojiang AU - Lemon, William C AU - Peabody, Nathan C AU - Pohl, Jascha B AU - Zelensky, Paul K AU - Wang, Ding AU - Nitabach, Michael N AU - Holmes, Todd C AU - White, Benjamin H AD - Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, and Department of Biology, New York University, New York, New York 10003 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 573 EP - 584 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 2 SN - 0270-6474, 0270-6474 KW - Diptera KW - bursicon KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Entomology Abstracts KW - Hemolymph KW - Protein kinase A KW - Crustacean cardioactive peptide KW - Neural networks KW - Secretion KW - Wings KW - Cuticles KW - Hormones KW - Nervous system KW - Neurotransmission KW - Tanning KW - Eclosion KW - Synaptic transmission KW - Sodium channels KW - Drosophila KW - J 02410:Animal Diseases KW - N3 11031:Invertebrate nervous systems KW - Z 05165:Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17463599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Functional+Dissection+of+a+Neuronal+Network+Required+for+Cuticle+Tanning+and+Wing+Expansion+in+Drosophila&rft.au=Luan%2C+Haojiang%3BLemon%2C+William+C%3BPeabody%2C+Nathan+C%3BPohl%2C+Jascha+B%3BZelensky%2C+Paul+K%3BWang%2C+Ding%3BNitabach%2C+Michael+N%3BHolmes%2C+Todd+C%3BWhite%2C+Benjamin+H&rft.aulast=Luan&rft.aufirst=Haojiang&rft.date=2006-01-01&rft.volume=26&rft.issue=2&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hemolymph; Protein kinase A; Neural networks; Crustacean cardioactive peptide; Secretion; Wings; Cuticles; Hormones; Nervous system; Neurotransmission; Tanning; Eclosion; Sodium channels; Synaptic transmission; Drosophila ER - TY - JOUR T1 - A small RNA inhibits translation of the histone-like protein Hc1 in Chlamydia trachomatis AN - 17447857; 6574841 AB - The chromatin of chlamydial elementary bodies (EBs) is stabilized by proteins with sequence homology to eukaryotic H1. These histone homologues, termed Hc1 and Hc2, are expressed only during the late stages of the chlamydial life cycle concomitant with the reorganization of reticulate bodies (RBs) into metabolically inactive EBs. Hc1 and Hc2 play a major role in establishment of nucleoid structure as well as in downregulation of gene expression as RBs differentiate back to EBs. The effects of Hc1 on gene expression patterns requires that chlamydiae strictly control Hc1 activity. Hc1 expression and activity are thus regulated transcriptionally as well as post-transcriptionally. We describe here a small regulatory RNA (sRNA) that acts as an additional checkpoint to negatively regulate Hc1 synthesis. Coexpression of the sRNA with hctA, the gene that encodes Hc1, in Escherichia coli inhibited Hc1 translation but did not affect hctA mRNA transcription or stability. IhtA (inhibitor of hctA translation) was present only in purified RBs while Hc1 was present only in purified EBs. During infection IhtA, but not Hc1, was present in RBs and was downregulated while Hc1 was upregulated upon RB to EB differentiation. Thus, we propose that IhtA is part of a global regulatory circuit that controls differentiation of RBs to EBs during the chlamydial life cycle. JF - Molecular Microbiology AU - Grieshaber, Nicole A AU - Grieshaber, Scott S AU - Fischer, Elizabeth R AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, ted_hackstadt@nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 541 EP - 550 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 2 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - mRNA stability KW - Histones KW - Chromatin KW - Retinoblastoma protein KW - Chlamydia trachomatis KW - Transcription KW - Life cycle KW - Circuits KW - Infection KW - Gene expression KW - Differentiation KW - Homology KW - Escherichia coli KW - Nucleoids KW - Reticulate bodies KW - Post-transcription KW - Amino acid sequence KW - J 02726:RNA and ribosomes KW - N 14025:RNA/DNA role in infection & immune response KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17447857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=A+small+RNA+inhibits+translation+of+the+histone-like+protein+Hc1+in+Chlamydia+trachomatis&rft.au=Grieshaber%2C+Nicole+A%3BGrieshaber%2C+Scott+S%3BFischer%2C+Elizabeth+R%3BHackstadt%2C+Ted&rft.aulast=Grieshaber&rft.aufirst=Nicole&rft.date=2006-01-01&rft.volume=59&rft.issue=2&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04949.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - SuppNotes - Figures, 5; references, 31. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Translation; mRNA stability; Histones; Chromatin; Retinoblastoma protein; Life cycle; Transcription; Circuits; Infection; Gene expression; Differentiation; Homology; Nucleoids; Reticulate bodies; Post-transcription; Amino acid sequence; Escherichia coli; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04949.x ER - TY - JOUR T1 - P1 plasmid partition: in vivo evidence for the ParA- and ParB-mediated formation of an anchored parS complex in the absence of a partner parS AN - 17447322; 6571215 AB - ParA and ParB proteins and cis-acting site, parS, are required to partition plasmid P1 faithfully to daughter cells. The process may initiate from plasmids paired by ParB at which recruited ParA then acts to effect the separation. We previously reported evidence for ParB-mediated pairing of parS sites on plasmids in the absence of ParA. In DNA gyrase-inhibited cells, the pairing prevented diffusion of transcription-generated positive supercoils. This supercoil trapping was almost entirely in plasmid dimers, where the location of the parS sites in cis facilitated their pairing. Here we show that the addition of ParA blocked supercoil diffusion also in plasmid monomers. The possibility that this result is attributed to an enhancement by ParA of ParB-mediated pairing in trans is consistent with our finding that ParA appeared to partially suppress the pairing defect of two mutant ParB proteins. However, enhanced pairing alone could not account for the diffusion barrier in plasmid monomers; it was manifest in monomers even when they were largely devoid of partners in the same cell. Apparently, ParA altered the ParB-parS complex such that it could no longer swivel, most likely by anchoring it, a reaction of probable relevance to partition. JF - Molecular Microbiology AU - Edgar, Rotem AU - Biek, Donald AU - Yarmolinsky, Michael AD - Laboratory of Biochemistry, National Cancer Institute, NIH 37 Convent Drive, Bethesda, MD 20892-4255, USA, donald.biek@appliedbiosystems.com Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 276 EP - 287 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 1 SN - 0950-382X, 0950-382X KW - ParS protein KW - Microbiology Abstracts B: Bacteriology KW - Monomers KW - ParA protein KW - DNA KW - Transcription KW - Diffusion KW - ParB protein KW - Plasmids KW - J 02760:Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17447322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=P1+plasmid+partition%3A+in+vivo+evidence+for+the+ParA-+and+ParB-mediated+formation+of+an+anchored+parS+complex+in+the+absence+of+a+partner+parS&rft.au=Edgar%2C+Rotem%3BBiek%2C+Donald%3BYarmolinsky%2C+Michael&rft.aulast=Edgar&rft.aufirst=Rotem&rft.date=2006-01-01&rft.volume=59&rft.issue=1&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04933.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - SuppNotes - Figures, 6; tables, 1; references, 43. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; ParA protein; DNA; Transcription; ParB protein; Diffusion; Plasmids DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04933.x ER - TY - JOUR T1 - Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response AN - 17443566; 6574853 AB - The cellular responses of Borrelia burgdorferiTo reactive oxygen species (ROS) encountered during the different stages of its infective cycle are poorly understood. Few enzymes responsible for protecting proteins, DNA-RNA and lipids from damage by ROS have been identified and characterized. Data presented here suggest that bb0728 encodes an enzyme involved in this process. Biochemical analyses on purified recombinant BB0728 indicated that it functioned as a coenzyme A disulphide reductase (CoADR) (specific activity approximately 26 units per mg of protein). This enzyme was specific for coenzyme A (CoA) disulphide, required NADH and had no significant activity against other disulphides, such as oxidized glutathione or thioredoxin. The high intracellular concentration of reduced CoA (CoASH) in B. burgdorferi cells ( similar to 1 mM) and absence of glutathione suggest that CoA is the major low-molecular-weight thiol in this spirochete. Interestingly, CoASH was able to reduce H sub(2)O sub(2) and be regenerated by CoADR suggesting one role for the system may be to protect B. burgdorferi from ROS. Further, mobility-shift assays and transcriptional fusion data indicated that bb0728 was positively regulated by the Borrelia oxidative stress response regulator, BosR. Taken together, these data suggest a role for BB0728 in intracellular redox and the oxidative stress response in B. burgdorferi. JF - Molecular Microbiology AU - Boylan, Julie A AU - Hummel, Charles S AU - Benoit, Stephane AU - Garcia-Lara, Jorge AU - Treglown-Downey, Jennifer AU - Crane, Edward J AU - Gherardini, Frank C AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, fgherardini@niaid.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 475 EP - 486 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 2 SN - 0950-382X, 0950-382X KW - Bb0728 protein KW - Microbiology Abstracts B: Bacteriology KW - Thioredoxin KW - Borrelia burgdorferi KW - Glutathione KW - Lymphocytes B KW - Lipids KW - NADH KW - Transcription KW - disulfide reductase KW - Spirochetes KW - Coenzyme A KW - Reactive oxygen species KW - Oxidative stress KW - Hydrogen peroxide KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17443566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Borrelia+burgdorferi+bb0728+encodes+a+coenzyme+A+disulphide+reductase+whose+function+suggests+a+role+in+intracellular+redox+and+the+oxidative+stress+response&rft.au=Boylan%2C+Julie+A%3BHummel%2C+Charles+S%3BBenoit%2C+Stephane%3BGarcia-Lara%2C+Jorge%3BTreglown-Downey%2C+Jennifer%3BCrane%2C+Edward+J%3BGherardini%2C+Frank+C&rft.aulast=Boylan&rft.aufirst=Julie&rft.date=2006-01-01&rft.volume=59&rft.issue=2&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04963.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - SuppNotes - Figures, 6; tables, 2; references, 38. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Thioredoxin; Spirochetes; Coenzyme A; Reactive oxygen species; Lymphocytes B; Hydrogen peroxide; Glutathione; Oxidative stress; Lipids; NADH; Transcription; disulfide reductase; Borrelia burgdorferi DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04963.x ER - TY - JOUR T1 - Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs AN - 17442855; 6571211 AB - Small non-coding RNAs that play important regulatory roles exist in numerous organisms. In Escherichia coli, about 60 small RNAs have been found and those that have been studied are involved in the response and adaptation to different stresses. RygA and RygB, two of these small RNAs, were identified on the basis of their conservation between different species and their ability to bind Hfq. They are adjacent on the chromosome and have sequence similarity at their 5' and 3' ends but distinct central regions, suggesting that they could regulate the expression of both common and distinct genes. A screen using a multicopy E. coli library led to identification of the response regulator OmpR and its associated sensor kinase EnvZ as positive regulators of rygA and rygB transcription. Therefore, RygA and RygB were renamed OmrA and OmrB respectively (for OmpR-regulated sRNAs A and B). When expressed at high levels, OmrA and OmrB RNAs negatively regulate the expression of several genes encoding multiple outer membrane proteins, including cirA, fecA, fepA and ompT. Taken together, these data suggest that OmrA and OmrB participate in the regulation of outer membrane composition in response to environmental conditions. JF - Molecular Microbiology AU - Guillier, Maude AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, susang@helix.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 231 EP - 247 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 1 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Chromosomes KW - Adaptations KW - outer membrane proteins KW - Escherichia coli KW - non-coding RNA KW - Conservation KW - Transcription KW - Stress KW - Environmental conditions KW - J 02726:RNA and ribosomes KW - N 14045:Transcriptional regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17442855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Remodelling+of+the+Escherichia+coli+outer+membrane+by+two+small+regulatory+RNAs&rft.au=Guillier%2C+Maude%3BGottesman%2C+Susan&rft.aulast=Guillier&rft.aufirst=Maude&rft.date=2006-01-01&rft.volume=59&rft.issue=1&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04929.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - SuppNotes - Figures, 6; tables, 4; references, 60. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; outer membrane proteins; Adaptations; non-coding RNA; Stress; Transcription; Conservation; Environmental conditions; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04929.x ER - TY - JOUR T1 - ProTherm and ProNIT: thermodynamic databases for proteins and protein-nucleic acid interactions AN - 17436338; 6580296 AB - ProTherm and ProNIT are two thermodynamic databases that contain experimentally determined thermodynamic parameters of protein stability and protein-nucleic acid interactions, respectively. The current versions of both the databases have considerably increased the total number of entries and enhanced search interface with added new fields, improved search, display and sorting options. As on September 2005, ProTherm release 5.0 contains 17 113 entries from 771 proteins, retrieved from 1497 scientific articles ( similar to 20% increase in data from the previous version). ProNIT release 2.0 contains 4900 entries from 273 research articles, representing 158 proteins. Both databases can be queried using WWW interfaces. Both quick search and advanced search are provided on this web page to facilitate easy retrieval and display of the data from these databases. ProTherm is freely available online at http://gibk26.bse.kyutech.ac.jp/jouhou/Protherm/protherm.html and ProNIT at http://gibk26.bse.kyutech.ac.jp/jouhou/pronit/pronit.html. JF - Nucleic Acids Research AU - Kumar, MDShaji AU - Bava, KAbdulla AU - Gromiha, MMichael AU - Prabakaran, Ponraj AU - Kitajima, Koji AU - Uedaira, Hatsuho AU - Sarai, Akinori AD - Department of Bioscience and Bioinformatics, Kyushu Institute of Technology (KIT) 680-4 Kawazu Iizuka, 820-8502 Japan. Advanced Technology Institute, Inc. (ATI) 2-3-13-103 Tate, Shiki, Saitama 353-0006, Japan. Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST) AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan. Laboratory of Experimental and Computational Biology, NCI, NIH Frederick, MD 21702, USA. Tsukuba Materials Information Laboratory 3-23-4, Ninomiya, Tsukuba, 305-0051 Japan Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - D204 EP - D206 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 34 SN - 0305-1048, 0305-1048 KW - protein-nucleic acid interactions KW - protein stability KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - Thermodynamics KW - N 14941:Miscellaneous KW - W 30965:Miscellaneous, Reviews KW - W4 350:Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17436338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=ProTherm+and+ProNIT%3A+thermodynamic+databases+for+proteins+and+protein-nucleic+acid+interactions&rft.au=Kumar%2C+MDShaji%3BBava%2C+KAbdulla%3BGromiha%2C+MMichael%3BPrabakaran%2C+Ponraj%3BKitajima%2C+Koji%3BUedaira%2C+Hatsuho%3BSarai%2C+Akinori&rft.aulast=Kumar&rft.aufirst=MDShaji&rft.date=2006-01-01&rft.volume=34&rft.issue=&rft.spage=D204&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Thermodynamics ER - TY - JOUR T1 - Automatically Identifying Health Outcome Information in MEDLINE Records AN - 17433029; 6581654 AB - OBJECTIVE: Understanding the effect of a given intervention on the patient's health outcome is one of the key elements in providing optimal patient care. This study presents a methodology for automatic identification of outcomes-related information in medical text and evaluates its potential in satisfying clinical information needs related to health care outcomes. DESIGN: An annotation scheme based on an evidence-based medicine model for critical appraisal of evidence was developed and used to annotate 633 MEDLINE citations. Textual, structural, and meta-information features essential to outcome identification were learned from the created collection and used to develop an automatic system. Accuracy of automatic outcome identification was assessed in an intrinsic evaluation and in an extrinsic evaluation, in which ranking of MEDLINE search results obtained using PubMed Clinical Queries relied on identified outcome statements. MEASUREMENTS: The accuracy and positive predictive value of outcome identification were calculated. Effectiveness of the outcome-based ranking was measured using mean average precision and precision at rank 10. RESULTS: Automatic outcome identification achieved 88% to 93% accuracy. The positive predictive value of individual sentences identified as outcomes ranged from 30% to 37%. Outcome-based ranking improved retrieval accuracy, tripling mean average precision and achieving 389% improvement in precision at rank 10. CONCLUSION: Preliminary results in outcome-based document ranking show potential validity of the evidence-based medicine-model approach in timely delivery of information critical to clinical decision support at the point of service. JF - Journal of the American Medical Informatics Association AU - Demner-Fushman, Dina AU - Few, Barbara AU - Hauser, Susan E AU - Thoma, George AD - Lister Hill National Center for Biomedical Communications, Communications Engineering Branch, National Library of Medicine, National Institutes of Health, Bethesda, MD Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 52 EP - 60 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 13 IS - 1 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Databases KW - Bioinformatics KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17433029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Automatically+Identifying+Health+Outcome+Information+in+MEDLINE+Records&rft.au=Demner-Fushman%2C+Dina%3BFew%2C+Barbara%3BHauser%2C+Susan+E%3BThoma%2C+George&rft.aulast=Demner-Fushman&rft.aufirst=Dina&rft.date=2006-01-01&rft.volume=13&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Bioinformatics ER - TY - JOUR T1 - Correlation between Lethal Toxin-Neutralizing Antibody Titers and Protection from Intranasal Challenge with Bacillus anthracis Ames Strain Spores in Mice after Transcutaneous Immunization with Recombinant Anthrax Protective Antigen AN - 17431117; 6576981 AB - Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain B. anthracis spores. A highly significant correlation was observed between toxin-neutralizing antibody titer and survival after challenge. Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy. JF - Infection and Immunity AU - Peachman, Kristina K AU - Rao, Mangala AU - Alving, Carl R AU - Burge, Robert AU - Leppla, Stephen H AU - Rao, Venigalla B AU - Matyas, Gary R AD - Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland 20850. Division of Biometrics, Walter Reed Army Institute of Research, Silver Spring, Maryland. National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland. The Catholic University of America, Washington, D.C Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 794 EP - 797 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - Primates KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Antibodies KW - protective antigen KW - Survival KW - Anthrax KW - Vaccines KW - Bacillus anthracis KW - Spores KW - Immunization KW - Lethal dose KW - J 02834:Vaccination and immunization KW - X 24370:Natural Toxins KW - F 06100:Vaccines - active immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17431117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Correlation+between+Lethal+Toxin-Neutralizing+Antibody+Titers+and+Protection+from+Intranasal+Challenge+with+Bacillus+anthracis+Ames+Strain+Spores+in+Mice+after+Transcutaneous+Immunization+with+Recombinant+Anthrax+Protective+Antigen&rft.au=Peachman%2C+Kristina+K%3BRao%2C+Mangala%3BAlving%2C+Carl+R%3BBurge%2C+Robert%3BLeppla%2C+Stephen+H%3BRao%2C+Venigalla+B%3BMatyas%2C+Gary+R&rft.aulast=Peachman&rft.aufirst=Kristina&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; protective antigen; Anthrax; Survival; Vaccines; Spores; Immunization; Lethal dose; Bacillus anthracis; Primates ER - TY - JOUR T1 - Inhibition of Chlamydiae by Primary Alcohols Correlates with the Strain-Specific Complement of Plasticity Zone Phospholipase D Genes AN - 17426896; 6576968 AB - Members of the genus Chlamydia are obligate intracellular pathogens that have a unique biphasic developmental cycle and interactions with host cells. Many genes that dictate host infection tropism and, putatively, pathogenic manifestations of disease are clustered in a hypervariable region of the genome termed the plasticity zone (PZ). Comparative genomics studies have determined that an uncharacterized family of PZ genes encoding orthologs of eukaryotic and prokaryotic members of the phospholipase D (PLD) enzyme family varies among chlamydiae. Here, we show that the PZ PLD (pzPLD) of Chlamydia trachomatis are transcribed during both normal and persistent infection and that the corresponding PLD proteins are predominately localized in reticulate bodies on the inner leaflet of the inclusion membrane. Further, we show that strains of chlamydiae encoding the pzPLD, but not a strain lacking these genes, are inhibited by primary alcohols, potent PLD inhibitors, during growth in HeLa 229 cells. This inhibitory effect is amplified approximately 5,000-fold during recovery from persistent infection. These findings suggest that the chlamydial pzPLD may be important, strain-specific, pathogenesis factors in vivo. JF - Infection and Immunity AU - Nelson, David E AU - Crane, Deborah D AU - Taylor, Lacey D AU - Dorward, David W AU - Goheen, Morgan M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 73 EP - 80 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 1 SN - 0019-9567, 0019-9567 KW - PZ gene KW - Genetics Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Plasticity (developmental) KW - Phospholipase D KW - Complement KW - Tropism KW - alcohols KW - Chlamydia trachomatis KW - Enzymes KW - genomics KW - Reticulate bodies KW - Pathogens KW - Persistent infection KW - F 06106:Bacteria KW - G 07770:Bacteria KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17426896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Inhibition+of+Chlamydiae+by+Primary+Alcohols+Correlates+with+the+Strain-Specific+Complement+of+Plasticity+Zone+Phospholipase+D+Genes&rft.au=Nelson%2C+David+E%3BCrane%2C+Deborah+D%3BTaylor%2C+Lacey+D%3BDorward%2C+David+W%3BGoheen%2C+Morgan+M%3BCaldwell%2C+Harlan+D&rft.aulast=Nelson&rft.aufirst=David&rft.date=2006-01-01&rft.volume=74&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Plasticity (developmental); Tropism; Complement; Phospholipase D; alcohols; Enzymes; Pathogens; Reticulate bodies; genomics; Persistent infection; Chlamydia trachomatis ER - TY - JOUR T1 - Potent Neutralization of Hendra and Nipah Viruses by Human Monoclonal Antibodies AN - 17421996; 6578422 AB - Hendra virus (HeV) and Nipah virus (NiV) are closely related emerging viruses comprising the Henipavirus genus of the PARAMYXOVIRINAE: Each has a broad species tropism and can cause disease with high mortality in both animal and human hosts. These viruses infect cells by a pH-independent membrane fusion event mediated by their attachment (G) and fusion (F) envelope glycoproteins (Envs). Seven Fabs, m101 to -7, were selected for their significant binding to a soluble form of Hendra G (sG) which was used as the antigen for panning of a large naive human antibody library. The selected Fabs inhibited, to various degrees, cell fusion mediated by the HeV or NiV Envs and virus infection. The conversion of the most potent neutralizer of infectious HeV, Fab m101, to immunoglobulin G1 (IgG1) significantly increased its cell fusion inhibitory activity: the 50% inhibitory concentration was decreased more than 10-fold to approximately 1 mu g/ml. The IgG1 m101 was also exceptionally potent in neutralizing infectious HeV; complete (100%) neutralization was achieved with 12.5 mu g/ml, and 98% neutralization required only 1.6 mu g/ml. The inhibition of fusion and infection correlated with binding of the Fabs to full-length G as measured by immunoprecipitation and less with binding to sG as measured by enzyme-linked immunosorbent assay and Biacore. m101 and m102 competed with the ephrin-B2, which we recently identified as a functional receptor for both HeV and NiV, indicating a possible mechanism of neutralization by these antibodies. The m101, m102, and m103 antibodies competed with each other, suggesting that they bind to overlapping epitopes which are distinct from the epitopes of m106 and m107. In an initial attempt to localize the epitopes of m101 and m102, we measured their binding to a panel of 11 G alanine-scanning mutants and identified two mutants, P185A and Q191 K192A, which significantly decreased binding to m101 and one, G183, which decreased binding of m102 to G. These results suggest that m101 to -7 are specific for HeV or NiV or both and exhibit various neutralizing activities; they are the first human monoclonal antibodies identified against these viruses and could be used for treatment, prophylaxis, and diagnosis and as research reagents and could aid in the development of vaccines. JF - Journal of Virology AU - Zhu, Zhongyu AU - Dimitrov, Antony S AU - Bossart, Katharine N AU - Crameri, Gary AU - Bishop, Kimberly A AU - Choudhry, Vidita AU - Mungall, Bruce A AU - Feng, Yan-Ru AU - Choudhary, Anil AU - Zhang, Mei-Yun AU - Feng, Yang AU - Wang, Lin-Fa AU - Xiao, Xiaodong AU - Eaton, Bryan T AU - Broder, Christopher C AU - Dimitrov, Dimiter S AD - Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland 21702. BRP, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702. Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814. CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 891 EP - 899 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 2 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Envelopes KW - Glycoproteins KW - antibody libraries KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Immunoprecipitation KW - Prophylaxis KW - Immunoglobulin G KW - Vaccines KW - Hendra virus KW - Infection KW - Cell fusion KW - Epitopes KW - Mortality KW - Membrane fusion KW - Tropism KW - Panning KW - Hepatitis E virus KW - Nipah virus KW - Fab KW - W3 33375:Antibodies KW - V 22091:Immunological techniques & reagents KW - W 30965:Miscellaneous, Reviews KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17421996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Potent+Neutralization+of+Hendra+and+Nipah+Viruses+by+Human+Monoclonal+Antibodies&rft.au=Zhu%2C+Zhongyu%3BDimitrov%2C+Antony+S%3BBossart%2C+Katharine+N%3BCrameri%2C+Gary%3BBishop%2C+Kimberly+A%3BChoudhry%2C+Vidita%3BMungall%2C+Bruce+A%3BFeng%2C+Yan-Ru%3BChoudhary%2C+Anil%3BZhang%2C+Mei-Yun%3BFeng%2C+Yang%3BWang%2C+Lin-Fa%3BXiao%2C+Xiaodong%3BEaton%2C+Bryan+T%3BBroder%2C+Christopher+C%3BDimitrov%2C+Dimiter+S&rft.aulast=Zhu&rft.aufirst=Zhongyu&rft.date=2006-01-01&rft.volume=80&rft.issue=2&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hepatitis E virus; Nipah virus; Hendra virus; Fab; Epitopes; Immunoglobulin G; Cell fusion; Monoclonal antibodies; Prophylaxis; Enzyme-linked immunosorbent assay; Immunoprecipitation; Mortality; Vaccines; antibody libraries; Membrane fusion; Tropism; Glycoproteins; Panning; Envelopes; Infection ER - TY - JOUR T1 - Adolescent Nicotine Metabolism: Ethnoracial Differences Among Dependent Smokers AN - 17256537; 6964449 AB - Variations in nicotine metabolism are thought to contribute to differences in cigarette consumption between African Americans and Caucasian adult smokers. To investigate the potential mechanism of previously documented lower smoking rates among African-American adolescent smokers seeking cessation treatment, we measured nicotine metabolite ratios as markers of the metabolic disposition of nicotine, which is generally considered to be under the influence of cytochrome P450 (CYP) 2A6. Plasma ratios of trans-3'-hydroxycotinine (3HC) to cotinine (COT) were examined in 92 cessation treatment-seeking adolescents (mean age 15.2 years, standard deviation [SD] 1.3, 69% female, 31% African American, mean Fagerstroem Test for Nicotine Dependence [FTND] 6.5, SD 1.6, mean years smoked 2.6, SD 1.6). Groups were similar in age, gender distribution, and mean FTND score. Analysis with independent t tests revealed significantly lower number of cigarettes per day (CPD) (15.1, SD 7.6 vs 19.6, SD 8.0, P=.013) and nicotine metabolite ratios (0.27, SD 0.15 vs 0.35, SD 0.16, P=.026) in African-American compared to Caucasian adolescent smokers. Consistent with metabolic variation, mean COT/CPD ratio was significantly higher in African- American compared to Caucasian adolescents. Results remained statistically significant when comparing menthol smokers by ethnicity. These findings are consistent with those found among adult smokers and provide a putative mechanism for reported ethnoracial differences in adolescent cigarette consumption. Our results underscore the need for measures independent of consumption for determining degree of nicotine dependence and treatment selection across ethnicities, even among youths. JF - Ethnicity & Disease AU - Moolchan, Eric T AU - Franken, Frederick H AU - Jaszyna-Gasior, Maria AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland Y1 - 2006 PY - 2006 DA - 2006 SP - 239 EP - 243 PB - International Society on Hypertension in Blacks, 2045 Manchester St, NE Atlanta GA 30324 USA, [URL:http://www.ishib.org] VL - 16 IS - 1 SN - 1049-510X, 1049-510X KW - Physical Education Index KW - Measurement KW - Statistics KW - Blacks KW - Adolescence KW - Adults KW - Smoking KW - Analysis KW - Gender KW - Tobacco KW - Diseases KW - Metabolism KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17256537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Disease&rft.atitle=Adolescent+Nicotine+Metabolism%3A+Ethnoracial+Differences+Among+Dependent+Smokers&rft.au=Moolchan%2C+Eric+T%3BFranken%2C+Frederick+H%3BJaszyna-Gasior%2C+Maria&rft.aulast=Moolchan&rft.aufirst=Eric&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Disease&rft.issn=1049510X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smoking; Measurement; Statistics; Blacks; Analysis; Adolescence; Gender; Tobacco; Diseases; Adults; Youth; Metabolism ER - TY - JOUR T1 - Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort AN - 17250184; 6986213 AB - Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self-reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer. Published 2006 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Abnet, Christian C AU - Fan, Jin-Hu AU - Kamangar, Farin AU - Sun, Xiu-Di AU - Taylor, Philip R AU - Ren, Jian-Song AU - Mark, Steven D AU - Zhao, Ping AU - Fraumeni Jr, Joseph F AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, abnetc@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1508 EP - 1510 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 6 SN - 0020-7136, 0020-7136 KW - goiter KW - Risk Abstracts KW - gastric cancer KW - esophageal cancer KW - iodine deficiency KW - China KW - Antioxidants KW - Iodine KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17250184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Self-reported+goiter+is+associated+with+a+significantly+increased+risk+of+gastric+noncardia+adenocarcinoma+in+a+large+population-based+Chinese+cohort&rft.au=Abnet%2C+Christian+C%3BFan%2C+Jin-Hu%3BKamangar%2C+Farin%3BSun%2C+Xiu-Di%3BTaylor%2C+Philip+R%3BRen%2C+Jian-Song%3BMark%2C+Steven+D%3BZhao%2C+Ping%3BFraumeni+Jr%2C+Joseph+F%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2006-01-01&rft.volume=119&rft.issue=6&rft.spage=1508&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21993 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antioxidants; Iodine; Cancer DO - http://dx.doi.org/10.1002/ijc.21993 ER - TY - JOUR T1 - No association between HPV infection and the neoplastic progression of esophageal squamous cell carcinoma: Result from a cross-sectional study in a high-risk region of China AN - 17248852; 6986190 AB - Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) infection and esophageal squamous cell carcinoma (ESCC) and related precursor lesions in a high-risk area of China. We conducted a cross- sectional study among adult inhabitants of Linxian, China. All subjects were interviewed about potential risk factors, had the length of their esophagus sampled by a balloon cytology examination and underwent endoscopy with mucosal iodine staining and biopsy of all unstained lesions. A multivalent HPV hybridization probe, Digene Hybrid Capture II (Gaithersburg, MD), which recognizes high-risk types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, was used to determine the HPV infection status of the cytologic specimens, and the endoscopic biopsies were used to classify each subject's esophageal disease. 740 subjects completed the cytologic and endoscopic exams, and 702 had adequate cytologic and biopsy specimens. Using a cutpoint of [ge]3.0 pg/ml of HPV DNA to define a positive test, HPV positivity was identified in 13% (61/475) of subjects without squamous dysplasia, 8% (8/102) with mild dysplasia, 7% (6/83) with moderate dysplasia, 16% (6/38) with severe dysplasia and zero (0/4) with invasive ESCC. Changing the cutpoint defining a positive test did not change the association of HPV infection and dysplasia grade. In this high-risk population, infection of esophageal cells with high-risk HPV types occurs in 13% of asymptomatic adults with no evidence of squamous dysplasia and a similar proportion of individuals with mild, moderate or severe dysplasia. This suggests that HPV infection is not a major risk factor for ESCC in this high-risk Chinese population. Further studies are warranted to determine if infection with this agent is associated with neoplastic progression in a subset of cases. JF - International Journal of Cancer AU - Gao, Guo-Fu AU - Roth, Mark J AU - Wei, Wen-Qiang AU - Abnet, Christian C AU - Chen, Feng AU - Lu, Ning AU - Zhao, Fang-Hui AU - Li, Xin-Qing AU - Wang, Guo-Qing AU - Taylor, Philip R AU - Pan, Qin-Jing AU - Chen, Wen AU - Dawsey, Sanford M AU - Qiao, You-Lin AD - Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China, dawseys@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1354 EP - 1359 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 6 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - esophageal squamous cell carcinoma KW - HPV KW - Hybrid Captur IIE KW - Mortality KW - Etiology KW - infection KW - DNA KW - Lesions KW - Iodine KW - China, People's Rep. KW - Developing countries KW - Cancer KW - Human papillomavirus KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17248852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=No+association+between+HPV+infection+and+the+neoplastic+progression+of+esophageal+squamous+cell+carcinoma%3A+Result+from+a+cross-sectional+study+in+a+high-risk+region+of+China&rft.au=Gao%2C+Guo-Fu%3BRoth%2C+Mark+J%3BWei%2C+Wen-Qiang%3BAbnet%2C+Christian+C%3BChen%2C+Feng%3BLu%2C+Ning%3BZhao%2C+Fang-Hui%3BLi%2C+Xin-Qing%3BWang%2C+Guo-Qing%3BTaylor%2C+Philip+R%3BPan%2C+Qin-Jing%3BChen%2C+Wen%3BDawsey%2C+Sanford+M%3BQiao%2C+You-Lin&rft.aulast=Gao&rft.aufirst=Guo-Fu&rft.date=2006-01-01&rft.volume=119&rft.issue=6&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21980 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Etiology; DNA; infection; Iodine; Lesions; Developing countries; Cancer; Human papillomavirus; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.21980 ER - TY - JOUR T1 - Adaptive evolution by optimizing expression levels in different environments AN - 17244122; 6965939 AB - Organisms adapt to environmental changes through the fixation of mutations that enhance reproductive success. A recent study by Dekel and Alon demonstrated that Escherichia coli adapts to different growth conditions by fine-tuning protein levels, as predicted by a simple cost-benefit model. A study by Fong et al. showed that independent evolutionary trajectories lead to similar adaptive endpoints. Initial mutations on the path to adaptation altered the mRNA levels of numerous genes. Subsequent optimization through compensatory mutations restored the expression of most genes to baseline levels, except for a small set that retained differential levels of expression. These studies clarify how adaptation could occur by the alteration of gene expression. JF - Trends in Microbiology AU - Babu, MMadan AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, madanm@ncbi.nlm.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 11 EP - 14 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 14 IS - 1 SN - 0966-842X, 0966-842X KW - Microbiology Abstracts B: Bacteriology KW - Adaptations KW - Growth conditions KW - Reviews KW - Environmental changes KW - Escherichia coli KW - Mutation KW - Evolution KW - Breeding success KW - Models KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17244122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=Adaptive+evolution+by+optimizing+expression+levels+in+different+environments&rft.au=Babu%2C+MMadan%3BAravind%2C+L&rft.aulast=Babu&rft.aufirst=MMadan&rft.date=2006-01-01&rft.volume=14&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2005.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Adaptations; Growth conditions; Reviews; Environmental changes; Mutation; Evolution; Models; Breeding success; Escherichia coli DO - http://dx.doi.org/10.1016/j.tim.2005.11.005 ER - TY - JOUR T1 - One-time intradermal DNA vaccination in ear pinnae one year prior to infection protects dogs against rabies virus AN - 17243565; 6965990 AB - Rabid dog exposures result in >99% of human rabies deaths worldwide. Ninety- eight percent of these cases occur in developing countries. Thus, the best protection against human rabies would be prevention through adequate vaccination of the reservoir population. The difficulty in re-locating ownerless, freely roaming dogs for booster vaccinations, in addition to poor coverage with inadequate vaccines, suggests that a potentially inexpensive vaccine that elicits long-term protection after a single-dose could improve control of canine rabies in developing countries. One solution could be a DNA vaccine. We have previously determined that dogs vaccinated intradermally (i.d.) in ear pinnae with a rabies DNA vaccine expressing a rabies virus glycoprotein (G) produce high levels of neutralizing antibody that persist for at least 6 months. In the present study, we determined whether a one-time i.d. rabies DNA vaccination into ear pinnae 1 year before viral challenge would protect dogs against rabies virus. The dogs did not receive a booster vaccination. All dogs (100%) vaccinated i.d. in each ear pinna with 50 mu g of rabies DNA vaccine, or intramuscular (i.m.) with a commercial canine rabies vaccine survived a lethal dose of rabies virus. In contrast, 100% of dogs vaccinated i.m. with 100 mu g of rabies DNA developed rabies, as did 100% of negative control dogs that were vaccinated i.d. in each ear pinna or i.m. with DNA that did not express the rabies virus G. The data suggest that a one-time i.d. rabies DNA vaccination into ear pinnae offers a new approach to facilitate control of endemic canine rabies in developing countries. JF - Vaccine AU - Lodmell, Donald L AU - Ewalt, Larry C AU - Parnell, Michael J AU - Rupprecht, Charles E AU - Hanlon, Cathleen A AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, Hamilton MT 59840, USA, dlodmell@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 412 EP - 416 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 4 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Agricultural and Environmental Biotechnology Abstracts; Immunology Abstracts KW - Rabies KW - Dogs KW - One-time DNA vaccination KW - 100% long-term protection KW - Ear pinna KW - glycoprotein G KW - Antibodies KW - Data processing KW - DNA vaccines KW - Rabies virus KW - Ear KW - Vaccines KW - Infection KW - Developing countries KW - Lethal dose KW - W2 32365:Vaccines KW - V 22098:Immunization: Vaccines & vaccination: Animal KW - F 06100:Vaccines - active immunity KW - N 14845:Miscellaneous KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17243565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=One-time+intradermal+DNA+vaccination+in+ear+pinnae+one+year+prior+to+infection+protects+dogs+against+rabies+virus&rft.au=Lodmell%2C+Donald+L%3BEwalt%2C+Larry+C%3BParnell%2C+Michael+J%3BRupprecht%2C+Charles+E%3BHanlon%2C+Cathleen+A&rft.aulast=Lodmell&rft.aufirst=Donald&rft.date=2006-01-01&rft.volume=24&rft.issue=4&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; glycoprotein G; Data processing; DNA vaccines; Rabies; Ear; Vaccines; Infection; Developing countries; Lethal dose; Rabies virus DO - http://dx.doi.org/10.1016/j.vaccine.2005.08.003 ER - TY - JOUR T1 - From transcriptome to immunome: Identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library AN - 17242756; 6965986 AB - Delayed-type hypersensitivity (DTH) response to arthropod vector salivary proteins is associated with protection against pathogen transmission. Massive cDNA sequencing, high-throughput DNA plasmid construction and DNA immunisation were used to identify twelve DTH inducing proteins isolated from a Phlebotomus ariasi salivary gland cDNA library. Additionally, nine P. ariasi DNA plasmids produced specific anti-saliva antibodies, four of these showed a Th1 immune response while the other two exhibited a Th2 profile as determined by IgG2a and IgG1 isotype switching, respectively. In order to validate the specificity of sand fly DNA plasmids, mice previously exposed to sand fly saliva were intradermally injected once with selected P. ariasi plasmids and a specific DTH response consisting of infiltration of mononuclear cells in varying proportions was observed at 24 and 48 h. This approach can help to identify DTH inducing proteins that may be related to host protection against vector-borne diseases or other disease agents where cellular immune response is protective. JF - Vaccine AU - Oliveira, Fabiano AU - Kamhawi, Shaden AU - Seitz, Amy E AU - Pham, van My AU - Guigal, Pierre M AU - Fischer, Laurent AU - Ward, Jerrold AU - Valenzuela, Jesus G AD - Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, 12735 Twinbrook Parkway, Room 2E-22C, Rockville, Maryland 20852, USA, jvalenzuela@niaid.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 374 EP - 390 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 3 SN - 0264-410X, 0264-410X KW - Moth flies KW - Biotechnology and Bioengineering Abstracts; Entomology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Cellular immune responses KW - DNA vaccine KW - Delayed-type hypersensitivity KW - Phlebotomus KW - Reverse antigen screening KW - Sand fly saliva KW - Sand fly transcripts KW - Phlebotomus ariasi KW - Leukocytes (mononuclear) KW - Helper cells KW - Vector-borne diseases KW - Pathogens KW - Salivary gland KW - Plasmids KW - Disease transmission KW - DNA sequencing KW - Hypersensitivity (delayed) KW - DNA vaccines KW - cDNA KW - Psychodidae KW - Immunoglobulin G KW - Lymphocytes T KW - Saliva KW - Immune response KW - Z 05182:Pathology KW - W3 33345:DNA vaccines KW - F 06300:Experimental: Immediate KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17242756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=From+transcriptome+to+immunome%3A+Identification+of+DTH+inducing+proteins+from+a+Phlebotomus+ariasi+salivary+gland+cDNA+library&rft.au=Oliveira%2C+Fabiano%3BKamhawi%2C+Shaden%3BSeitz%2C+Amy+E%3BPham%2C+van+My%3BGuigal%2C+Pierre+M%3BFischer%2C+Laurent%3BWard%2C+Jerrold%3BValenzuela%2C+Jesus+G&rft.aulast=Oliveira&rft.aufirst=Fabiano&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.07.085 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Leukocytes (mononuclear); Helper cells; Vector-borne diseases; Pathogens; Plasmids; Salivary gland; Disease transmission; DNA sequencing; DNA vaccines; Hypersensitivity (delayed); cDNA; Lymphocytes T; Immunoglobulin G; Immune response; Saliva; Phlebotomus ariasi; Psychodidae DO - http://dx.doi.org/10.1016/j.vaccine.2005.07.085 ER - TY - JOUR T1 - Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women AN - 17240213; 6986205 AB - Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathione- S-transferase M1 (GSTM1) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptibility to lung cancer. A case-only design was used with lung cancer cases pooled from 3 previously completed case-control studies using archival tissue samples from 270 lung cancer cases to genotype GSTM1. Radon concentrations were measured with long-term [alpha]-track radon detectors. Secondhand smoke (SHS) was measured with questionnaires and interviews. Unconditional logistic regression was used to calculate the interaction odds ratios (OR) and 95% confidence intervals (95% CI). Radon concentrations >121 Bq m super(-3) were associated with a >3-fold interaction OR (OR = 3.41; 95% CI = 1.10, 10.61) for GSTM1 null homozygotes compared to GSTM1 carriers; the linear trend was significant (p trend = 0.03). The SHS and GSTM1 interaction OR was also elevated (OR = 2.28; 95% CI = 1.15-4.51) among never-smokers. This may be the first study to provide evidence of a GSTM1 and radon interaction in risk of lung cancer. Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway. JF - International Journal of Cancer AU - Bonner, Matthew R AU - Bennett, William P AU - Xiong, Wenying AU - Lan, Qing AU - Brownson, Ross C AU - Harris, Curtis C AU - Field, RWilliam AU - Lubin, Jay H AU - Alavanja, Michael CR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, MD, mrbonner@buffalo.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 1462 EP - 1467 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 6 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts KW - radon KW - secondhand smoke KW - glutathione-S-transferase KW - lung cancer KW - epidemiology KW - Inventories KW - Genotypes KW - Glutathione transferase KW - Neoplasia KW - Homozygotes KW - Radon KW - Smoke KW - GSTM1 protein KW - Passive smoking KW - Reactive oxygen species KW - Oxidative stress KW - Ionizing radiation KW - Tobacco KW - Females KW - Lung cancer KW - X 24390:Radioactive Materials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17240213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Radon%2C+secondhand+smoke%2C+glutathione-S-transferase+M1+and+lung+cancer+among+women&rft.au=Bonner%2C+Matthew+R%3BBennett%2C+William+P%3BXiong%2C+Wenying%3BLan%2C+Qing%3BBrownson%2C+Ross+C%3BHarris%2C+Curtis+C%3BField%2C+RWilliam%3BLubin%2C+Jay+H%3BAlavanja%2C+Michael+CR&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2006-01-01&rft.volume=119&rft.issue=6&rft.spage=1462&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Genotypes; Glutathione transferase; Radon; Homozygotes; Neoplasia; Smoke; GSTM1 protein; Reactive oxygen species; Oxidative stress; Ionizing radiation; Tobacco; Lung cancer; Passive smoking; Females DO - http://dx.doi.org/10.1002/ijc.22002 ER - TY - JOUR T1 - Minimization of aggregation of secreted bivalent anti-human T cell immunotoxin in Pichia pastoris bioreactor culture by optimizing culture conditions for protein secretion AN - 17235320; 6932953 AB - In a bioreactor culture of genetically engineered Pichia pastoris secreting a bivalent immunotoxin, 64% of the secreted immunotoxin was present in aggregate forms and this resulted in a loss of bioactivity. Biochemical analyses of the secreted immunotoxin and an in vitro aggregation study using purified monomeric immunotoxin suggested that aggregation was primarily an extracellular event. By employing limited methanol feeding at 0.75 ml min super(-1) per 10 l initial medium, oxygen consumption was reduced, permitting a lowering of the bioreactor agitation speed from 800 to 400 rpm. By increasing the anti-foam reagent to 0.6 ml l super(-1), the thickness of the air/liquid interfacial foam layer was reduced by 80%. These steps reduced the immunotoxin aggregates from 64% to 5%. Consequently immunotoxin purification yield was increased from 53.0% to 73.8%. Simultaneously this methodology enhanced immunotoxin secretion to 120 mg l super(-1) at 163 h of methanol induction in a toxin resistant production strain. We conclude that minimizing shearing force and reducing the air/liquid interfacial foam area are crucial factors in reducing hydrophobic protein aggregation upon secretory expression in yeast bioreactor cultures. JF - Journal of Biotechnology AU - Woo, Jung Hee AU - Liu, Yuan Yi AU - Neville, David M AD - Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Bldg. 10 Rm. 3D46, 10 Center Drive, Bethesda, MD 20892-1216, USA, jwoo@swmail.sw.org Y1 - 2006 PY - 2006 DA - 2006 SP - 75 EP - 85 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 121 IS - 1 SN - 0168-1656, 0168-1656 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - Pichia pastoris KW - Protein secretion KW - Protein aggregation KW - Recombinant bivalent immunotoxin KW - Shearing force KW - Foam formation KW - Oxygen consumption KW - Feeding KW - Methanol KW - Biochemical analysis KW - Cell culture KW - Hydrophobicity KW - Foams KW - Immunotoxins KW - Toxins KW - Bioreactors KW - Genetic engineering KW - Lymphocytes T KW - W3 33580:Process engineering KW - W 30965:Miscellaneous, Reviews KW - W4 320:Cell Culture & Batch Fermentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17235320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biotechnology&rft.atitle=Minimization+of+aggregation+of+secreted+bivalent+anti-human+T+cell+immunotoxin+in+Pichia+pastoris+bioreactor+culture+by+optimizing+culture+conditions+for+protein+secretion&rft.au=Woo%2C+Jung+Hee%3BLiu%2C+Yuan+Yi%3BNeville%2C+David+M&rft.aulast=Woo&rft.aufirst=Jung&rft.date=2006-01-01&rft.volume=121&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biotechnology&rft.issn=01681656&rft_id=info:doi/10.1016%2Fj.jbiotec.2005.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Feeding; Genetic engineering; Bioreactors; Methanol; Lymphocytes T; Biochemical analysis; Hydrophobicity; Cell culture; Foams; Toxins; Immunotoxins; Pichia pastoris DO - http://dx.doi.org/10.1016/j.jbiotec.2005.07.004 ER - TY - JOUR T1 - Comparative evaluation of three different intramuscular delivery methods for DNA immunization in a nonhuman primate animal model AN - 17233821; 6965985 AB - Although plasmid DNA vaccines induce potent cell-mediated immune responses and prime for antibody responses in experimental laboratory animals, their immunogenicity in humans has been less remarkable. A number of strategies have been proposed to improve the immunogenicity of these vaccines, including using novel means of vaccine delivery. In the present study, the immunogenicity of three different methods of intramuscular plasmid DNA administration was compared in cynomolgus monkeys: needle and syringe, Biojector super([registered]) 2000, and Mini-Ject[TM]. The elicited cellular and humoral immune responses were comparable in monkeys immunized using these different delivery techniques, suggesting that the needle-free approaches to vaccine administration do not significantly improve the immunogenicity of the plasmid DNA vaccine used in the study. JF - Vaccine AU - Rao, Srinivas S AU - Gomez, Phillip AU - Mascola, John R AU - Dang, Vi AU - Krivulka, Georgia R AU - Yu, Faye AU - Lord, Carol I AU - Shen, Ling AU - Bailer, Robert AU - Nabel, Gary J AU - Letvin, Norman L AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, nletvin@bidmc.harvard.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 367 EP - 373 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 24 IS - 3 SN - 0264-410X, 0264-410X KW - Crab-eating macaque KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Nonhuman primate KW - DNA vaccination KW - AIDS vaccine KW - Delivery methods KW - i.m. injection KW - Macaca fascicularis KW - Laboratory animals KW - Animal models KW - Plasmids KW - Primates KW - Immunization KW - Antibodies KW - Immune response (cell-mediated) KW - DNA vaccines KW - Immunogenicity KW - Syringes KW - Cynomolgus KW - Vaccines KW - Immune response (humoral) KW - F 06100:Vaccines - active immunity KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17233821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Comparative+evaluation+of+three+different+intramuscular+delivery+methods+for+DNA+immunization+in+a+nonhuman+primate+animal+model&rft.au=Rao%2C+Srinivas+S%3BGomez%2C+Phillip%3BMascola%2C+John+R%3BDang%2C+Vi%3BKrivulka%2C+Georgia+R%3BYu%2C+Faye%3BLord%2C+Carol+I%3BShen%2C+Ling%3BBailer%2C+Robert%3BNabel%2C+Gary+J%3BLetvin%2C+Norman+L&rft.aulast=Rao&rft.aufirst=Srinivas&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2005.07.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Antibodies; Immune response (cell-mediated); DNA vaccines; Immunogenicity; Animal models; Laboratory animals; Syringes; Vaccines; Immune response (humoral); Plasmids; Immunization; Macaca fascicularis; Cynomolgus; Primates DO - http://dx.doi.org/10.1016/j.vaccine.2005.07.072 ER - TY - JOUR T1 - Physical activity and the risk of colon cancer among women: A prospective cohort study (United States) AN - 17232830; 6930773 AB - Physical activity has frequently been reported to decrease the risk of colon cancer in men, but data on the relation of physical activity to colon cancer risk in women have generally been less consistent. To further investigate the relationship of physical activity with colon cancer risk in women, we studied a cohort of 31,783 US women participating in the Breast Cancer Detection Demonstration Project Follow-up Study. Information on daily physical activity over the past year was ascertained using a self-administered questionnaire at study baseline. The Cox proportional hazards model was used to estimate relative risks (RRs) relating physical activity to the risk of incident colon cancer. During 270,325 person-years of follow-up, 243 colon cancer cases were identified. No association was observed between physical activity and the subsequent risk of colon cancer. The multivariable RRs of colon cancer across increasing quintiles of total physical activity were 1.0, 1.45, 1.16, 1.27 and 1.15 (95% CI: 0.76, 1.75; p sub(trend) = 0.77). The multivariable RRs comparing women at the extremes of moderate and vigorous physical activity, respectively, were 1.07 (95% CI: 0.70, 1.62) and 1.10 (95% CI: 0.78, 1.55). The relationship between physical activity and colon cancer risk did not vary by anatomic subsite or across subgroups defined by age, body mass, dietary fiber intake, menopausal status, menopausal hormone use or aspirin use. The results of this large prospective cohort study among women do not support the hypothesis that physical activity is related to a lower incidence of colon cancer. JF - International Journal of Cancer AU - Calton, Brook A AU - Lacey Jr, James V AU - Schatzkin, Arthur AU - Schairer, Catherine AU - Colbert, Lisa H AU - Albanes, Demetrius AU - Leitzmann, Michael F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA, brook.calton@ucsf.edu Y1 - 2006 PY - 2006 DA - 2006 SP - 385 EP - 391 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 2 SN - 0020-7136, 0020-7136 KW - colorectal carcinoma KW - Risk Abstracts; Physical Education Index KW - colon cancer KW - physical activity KW - exercise KW - intensity KW - cohort KW - prospective KW - Age KW - Physical activity KW - Body mass KW - Women KW - Surveys KW - Breasts KW - Exercise KW - Hormones KW - Cancer KW - USA KW - Females KW - Diet KW - Menopause KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Physical+activity+and+the+risk+of+colon+cancer+among+women%3A+A+prospective+cohort+study+%28United+States%29&rft.au=Calton%2C+Brook+A%3BLacey+Jr%2C+James+V%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BColbert%2C+Lisa+H%3BAlbanes%2C+Demetrius%3BLeitzmann%2C+Michael+F&rft.aulast=Calton&rft.aufirst=Brook&rft.date=2006-01-01&rft.volume=119&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21840 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Body mass; Women; Surveys; Breasts; Diet; Exercise; Hormones; Menopause; Cancer; Physical activity; Females; USA DO - http://dx.doi.org/10.1002/ijc.21840 ER - TY - JOUR T1 - Plasma Catecholamine Levels and Neurobehavioral Problems in Indian Firefighters AN - 17217876; 6906949 AB - Firefighting is a stressful and hazardous job. Persons engaged in firefighting are highly exposed to work-related stress as well as to smoke containing a host of chemicals potentially harmful to human health. In order to elucidate whether firefighting affects neuroendocrine and behavioral responses of firefighters, plasma catecholamine (CA) levels and the prevalence of neurobehavioral symptoms in 62 firefighters (all males, mean age 43 yr) and 52 control subjects matched for age and sex were examined in this study. Self- reported neurobehavioral symptoms data were obtained from a questionnaire survey and personal interview. Concentrations of epinephrine (E), norepinephrine (NE) and dopamine (DA) in plasma were measured by high-performance liquid chromatography with electrochemical detection. Compared with matched controls, the firefighters showed higher prevalence (p<0.05) of neurobehavioral symptoms such as burning sensation in the extremities, tingling and numbness, transient loss of memory, and depression, but no significant difference was recorded in the prevalences of anxiety, vertigo and dizziness. The firefighters demonstrated a more than two-fold (p<0.05) rise in plasma levels of E and NE, but the plasma da level was relatively unchanged. Controlling age and smoking as possible confounders, firefighting was found to be associated with raised E (OR=2.15; 95% CI, 0.98-4.52), and NE levels (OR=2.24 95% CI, 1.22-3.61). In conclusion, the job of firefighting appears to be associated with stimulation of sympathetic activity and a rise in the prevalence of neurobehavioral symptoms. JF - Journal of Occupational Health AU - Ray, Manas R AU - Basu, Chandreyi AU - Roychoudhury, Sanghita AU - Banik, Sampa AU - Lahiri, Twisha AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 210 EP - 215 PB - Japan Society for Occupational Health, Public Health Bldg., 1-29-8 Shinjuku Shinjuku-ku Tokyo 190 Japan VL - 48 IS - 3 SN - 1341-9145, 1341-9145 KW - Health & Safety Science Abstracts KW - Catecholamine KW - Neurobehavioral problem KW - Firefighter KW - India KW - Bioindicators KW - Smoking KW - firefighter services KW - Liquid chromatography KW - depression KW - Working conditions KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17217876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health&rft.atitle=Plasma+Catecholamine+Levels+and+Neurobehavioral+Problems+in+Indian+Firefighters&rft.au=Ray%2C+Manas+R%3BBasu%2C+Chandreyi%3BRoychoudhury%2C+Sanghita%3BBanik%2C+Sampa%3BLahiri%2C+Twisha&rft.aulast=Ray&rft.aufirst=Manas&rft.date=2006-01-01&rft.volume=48&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Bioindicators; Smoking; firefighter services; Liquid chromatography; depression; Working conditions; Occupational health ER - TY - JOUR T1 - Challenges and opportunities for enhancing biotechnology and technology transfer in developing countries AN - 17217348; 6932628 AB - Biotechnological innovation is gaining increased recognition as an important tool for improving global health. The challenge, however, lies in defining the role of technology transfer to develop therapies for diseases prevalent in developing countries. During the past decade, a large disparity emerged between the developed and developing world in accessing affordable medicines because of the pharmaceutical industry's focus on health areas bearing greatest profits. Discussed herein are several mechanisms that provide partial solutions to this challenge. The Office of Technology Transfer of the US National Institutes of Health has increased its technology licensing pertaining to neglected diseases to partners in developing regions. Establishing partnerships through the transfer of technologies and assisting indigenous institutions build R and D capacity may positively impact policies on protection of intellectual property rights and increase multinational company investments in lesser-developed countries. This will most probably result in the development of more accessible therapies for those in need. JF - Biotechnology Advances AU - Salicrup, Luis A AU - Fedorkova, Lenka AD - Office of the Director/Office of Technology Transfer, National Institutes of Health, Department of Health and Human Services, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852, USA, salicrul@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 69 EP - 79 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 24 IS - 1 SN - 0734-9750, 0734-9750 KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Technology transfer KW - Biomedical innovation KW - License strategies KW - Developing countries KW - Neglected diseases KW - Capacity building KW - International partnerships KW - intellectual property KW - Pharmaceuticals KW - W2 32000:General topics and reviews KW - W 30965:Miscellaneous, Reviews KW - W3 33000:General topics and reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17217348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Advances&rft.atitle=Challenges+and+opportunities+for+enhancing+biotechnology+and+technology+transfer+in+developing+countries&rft.au=Salicrup%2C+Luis+A%3BFedorkova%2C+Lenka&rft.aulast=Salicrup&rft.aufirst=Luis&rft.date=2006-01-01&rft.volume=24&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Advances&rft.issn=07349750&rft_id=info:doi/10.1016%2Fj.biotechadv.2005.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - intellectual property; Pharmaceuticals; Technology transfer; Developing countries DO - http://dx.doi.org/10.1016/j.biotechadv.2005.06.004 ER - TY - JOUR T1 - Developmental toxicity evaluation of berberine in rats and mice AN - 17212656; 6902738 AB - BACKGROUND: Berberine, a plant alkaloid, is found in some herbal teas and health-related products. It is a component of goldenseal, an herbal supplement. Berberine chloride dihydrate (BCD) was evaluated for developmental toxicity in rats and mice. METHODS: Berberine chloride dihydrate was administered in the feed to timed-mated Sprague-Dawley (CD) rats (0, 3625, 7250, or 14,500 ppm; on gestational days [GD] 6-20), and Swiss Albino (CD-1) mice (0, 3500, 5250, or 7000 ppm; on GD 6-17). Ingested doses were 0, 282, 531, and 1313 mg/kg/day (rats) and 0, 569, 841, and 1155 mg/kg/day (mice). RESULTS:There were no maternal deaths. The rat maternal lowest observed adverse effect level (LOAEL), based on reduced maternal weight gain, was 7250 ppm. The rat developmental toxicity LOAEL, based on reduced fetal body weight per litter, was 14,500 ppm. In the mouse study, equivocal maternal and developmental toxicity LOAELs were 5250 ppm. Due to scattering of feed in the high dose groups, a gavage study at 1000 mg/kg/day was conducted in both species. CONCLUSIONS: In rats, maternal, but not fetal adverse effects were noted. The maternal toxicity LOAEL remained at 7250 ppm (531 mg/kg/day) based on the feed study and the developmental toxicity NOAEL was raised to 1000 mg/kg/day BCD based on the gavage study. In the mouse, 33% of the treated females died. Surviving animals had increased relative water intake, and average fetal body weight per litter decreased 5-6% with no change in live litter size. The maternal toxicity LOAEL remained at 5250 ppm (841 mg/kg/day) BCD, based on increased water consumption. The developmental toxicity LOAEL was raised to 1000 mg/kg/day BCD based on decreased fetal body weight. Birth Defects Research (Part B) 77:195-206, 2006. Published 2006 Wiley-Liss, Inc. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Jahnke, Gloria D AU - Price, Catherine J AU - Marr, Melissa C AU - Myers, Christina B AU - George, Julia D AD - Sciences International Inc., Research Triangle Park, North Carolina, Jahnke@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 195 EP - 206 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 77 IS - 3 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - berberine KW - development KW - birth defects KW - rats KW - mice KW - pregnancy KW - herbal remedy KW - Alkaloids KW - Body weight KW - Water intake KW - Tea KW - Congenital defects KW - Chloride KW - Toxicity testing KW - Berberine KW - Fetuses KW - Side effects KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17212656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Developmental+toxicity+evaluation+of+berberine+in+rats+and+mice&rft.au=Jahnke%2C+Gloria+D%3BPrice%2C+Catherine+J%3BMarr%2C+Melissa+C%3BMyers%2C+Christina+B%3BGeorge%2C+Julia+D&rft.aulast=Jahnke&rft.aufirst=Gloria&rft.date=2006-01-01&rft.volume=77&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Alkaloids; Body weight; Tea; Water intake; Congenital defects; Chloride; Berberine; Toxicity testing; Side effects; Fetuses DO - http://dx.doi.org/10.1002/bdrb.20075 ER - TY - JOUR T1 - Isoenzymes and soluble protein in Arthrospira from alkaline lakes in Erdos Plateau, China and in exotic species AN - 17200992; 6868216 AB - The authors compared isoenzymes of five enzymes and soluble protein in Arthrospira platensis (A sub(3)) and A. erdosensis (A sub(4)) from alkaline lakes in Erdos Plateau, Nei Monggo (Inner Mongalia), China and exotic species of A. platensis (A sub(1)) from Chad and A. maxima (A sub(2)) from Mexico by means of polyacrylamide gel electrophoresis. The results showed that the isoenzymes of EST, POD and soluble protein were polymorphic. Monomorphism and polymorphism were found in isoenzymes of AMY, CAT and SOD, and monomorphism was found only in the introduced species. The isoenzymes and soluble protein of the local species are all polymorphic. The number of bands in these species were in the order of A sub(3)>A sub(4)>A sub(1)>A sub(2). A sub(2) is the most primary, A sub(1) from Chad Lake is relatively primary, A sub(3) and A sub(4) are advanced species in evolution. Cluster analysis showed that the relation between the two introduced species are the closest to each other, and so too are the two local ones. JF - Chinese Journal of Oceanology and Limnology AU - Yang, Qian AU - Li, Shuyuan AU - Hu, Ruiping AU - Liu, Yan AU - Qiao, Chen AD - Common Courses Department, Nei Monggo Medical College, Hohhot 010059, China Y1 - 2006 PY - 2006 DA - 2006 SP - 134 EP - 141 VL - 24 IS - 2 SN - 0254-4059, 0254-4059 KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Africa, Chad L. KW - Limnology KW - Freshwater KW - expressed sequence tags KW - Population genetics KW - Lakes KW - Exotic Species KW - Superoxide dismutase KW - Isoenzymes KW - Electrophoresis KW - Arthrospira platensis KW - Enzymes KW - Arthrospira KW - Gel electrophoresis KW - Mexico KW - Chad KW - Proteins KW - China, People's Rep. KW - Introduced species KW - Evolution KW - Q1 08186:Physiology, biochemistry, biophysics KW - SW 0850:Lakes KW - Q2 09101:General works KW - Q5 08521:Mechanical and natural changes KW - K 03024:Algae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17200992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Oceanology+and+Limnology&rft.atitle=Isoenzymes+and+soluble+protein+in+Arthrospira+from+alkaline+lakes+in+Erdos+Plateau%2C+China+and+in+exotic+species&rft.au=Yang%2C+Qian%3BLi%2C+Shuyuan%3BHu%2C+Ruiping%3BLiu%2C+Yan%3BQiao%2C+Chen&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2006-01-01&rft.volume=24&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Oceanology+and+Limnology&rft.issn=02544059&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Population genetics; Lakes; Isoenzymes; Proteins; Introduced species; Evolution; Superoxide dismutase; Enzymes; Limnology; expressed sequence tags; Gel electrophoresis; Electrophoresis; Exotic Species; Arthrospira platensis; Arthrospira; Mexico; Chad; Africa, Chad L.; China, People's Rep.; Freshwater ER - TY - JOUR T1 - Extractability and bioavailability of zinc over time in three tropical soils incubated with biosolids AN - 17194770; 6867059 AB - Phytotoxicity of heavy metal is the primary concern in applying biosolids (sewage sludge) to agricultural land. This study evaluates the changes in chemical speciation of Zn in three tropical soils of Taiwan measured with sequential extraction over a one-year period. Biosolids were applied to the soils at application rates of 10, 50 and 100 Mg ha super(-1), and correlated diethylene triamine pentaacetic acid (DTPA) and sequential extraction as extract for prediction of Zn bioavailability to Chinese cabbage (Brassica chinensis L.). Experimental results indicated that the exchangeable (F1) and Fe-Mn oxide (F3) fractions in the sequential extractions increased with application rate of biosolids in the soils over time. Large amounts of Zn in the soils following the cessation of biosolids application were identified as soluble and were adsorbed by Fe-Mn oxides. The organically bound Zn, which is associated with readily decomposable carbon, is in limited amounts in the biosolid-treated soils. The DTPA-extractable concentrations of Zn in all biosolid-treated soils decreased over the time. A positive and significant correlation (r super(2) = 0.96) was found between the Zn concentrations extracted with DTPA and sum of F1 and carbonate-bound (F2) fractions in the sequential extractions. Additionally, the concentrations of Zn extracted with DTPA were strongly correlated with the concentrations of Zn in the shoots of Chinese cabbages, indicating that F1 + F2 in the sequential extractions was reliable for predicting Zn bioavailability to Chinese cabbage in the biosolid-treated soils. JF - Chemosphere AU - Hseu, Zeng-Yei AD - Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei Pu, Pingtung 91201, Taiwan Y1 - 2006 PY - 2006 DA - 2006 SP - 762 EP - 771 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 63 IS - 5 SN - 0045-6535, 0045-6535 KW - Pollution Abstracts KW - Bioavailability KW - Biosolids KW - Brassica chinensis L. KW - Land application KW - Sequential extraction KW - Zinc KW - Soil KW - Brassica chinensis KW - Taiwan KW - Sewage sludge KW - Heavy metals KW - Chemical speciation KW - Phytotoxicity KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17194770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Extractability+and+bioavailability+of+zinc+over+time+in+three+tropical+soils+incubated+with+biosolids&rft.au=Hseu%2C+Zeng-Yei&rft.aulast=Hseu&rft.aufirst=Zeng-Yei&rft.date=2006-01-01&rft.volume=63&rft.issue=5&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2005.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Soil; Bioavailability; Heavy metals; Sewage sludge; Chemical speciation; Zinc; Phytotoxicity; Biosolids; Brassica chinensis; Taiwan DO - http://dx.doi.org/10.1016/j.chemosphere.2005.08.014 ER - TY - JOUR T1 - Abuse of prescription drugs and the risk of addiction AN - 17179298; 6834644 AB - Abuse of several categories of prescription drugs has increased markedly in the United States in the past decade and is now at alarming levels for certain agents, especially opioid analgesics and stimulants. Prescription drugs of abuse fit into the same pharmacological classes as their non-prescription counterparts. Thus, the potential factors associated with abuse or addiction versus safe therapeutic use of these agents relates to the expected variables: dose, route of administration, co-administration with other drugs, context of use, and expectations. Future scientific work on prescription drug abuse will include identification of clinical practices that minimize the risks of addiction, the development of guidelines for early detection and management of addiction, and the development of clinically effective agents that minimize the risks for abuse. With the high rates of prescription drug abuse among teenagers in the United States, a particularly urgent priority is the investigation of best practices for effective prevention and treatment for adolescents, as well as the development of strategies to reduce diversion and abuse of medications intended for medical use. JF - Drug and Alcohol Dependence AU - Compton, Wilson M AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Blvd., Bethesda, MD 20892, USA, wcompton@nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - S4 EP - S7 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 83 SN - 0376-8716, 0376-8716 KW - prescription drugs KW - Risk Abstracts KW - Prescription drug abuse KW - Drug dependence KW - Addiction KW - Opioid analgesic KW - USA KW - Prevention KW - Drug abuse KW - Drugs KW - Side effects KW - Adolescents KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17179298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Abuse+of+prescription+drugs+and+the+risk+of+addiction&rft.au=Compton%2C+Wilson+M%3BVolkow%2C+Nora+D&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2006-01-01&rft.volume=83&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.10.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Prevention; Drug abuse; Drugs; Adolescents; Side effects; USA DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.10.020 ER - TY - JOUR T1 - Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia AN - 17175310; 6837662 AB - Background: Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer. Methods: To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job- specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents. Results: In male workers, increased risks were found for linen dust (OR = 3.68, 95% CI 1.00-13.6, adjusted for age, smoking and residence), and unspecified DFs (OR = 1.44, 95% CI 1.07-1.94). Small non- significant excess risks were observed for quartz dust (OR = 1.27; 95% CI 0.83- 1.93) and man-made vitreous fibers (MMVFs) (OR = 1.82, 95% CI 0.88-3.75). In female subjects, risks were non-significantly associated with paper dust (OR = 1.77, 95% CI 0.74-4.20), and unspecified DFs (OR = 1.52, 95% CI 0.77-3.03). Conclusions: The study showed increased lung cancer risk for selected categories of DFs. Am. J. Ind. Med. 2006. Published 2006 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Baccarelli, Andrea AU - Khmelnitskii, Oleg AU - Tretiakova, Maria AU - Gorbanev, Sergey AU - Lomtev, Alexei AU - Klimkina, Irina AU - Tchibissov, Vladimir AU - Averkina, Olga AU - Rice, Carol AU - Dosemeci, Mustafa AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, andrea.baccarelli@unimi.it Y1 - 2006 PY - 2006 DA - 2006 SP - 460 EP - 467 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 49 IS - 6 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts; Risk Abstracts; Pollution Abstracts KW - glass wool KW - linen dust KW - man-made vitreous fibers KW - occupation KW - paper dust KW - particles KW - quartz KW - Inhalation KW - Fibers KW - Smoking KW - Russia KW - Dust KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17175310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Risk+of+lung+cancer+from+exposure+to+dusts+and+fibers+in+Leningrad+Province%2C+Russia&rft.au=Baccarelli%2C+Andrea%3BKhmelnitskii%2C+Oleg%3BTretiakova%2C+Maria%3BGorbanev%2C+Sergey%3BLomtev%2C+Alexei%3BKlimkina%2C+Irina%3BTchibissov%2C+Vladimir%3BAverkina%2C+Olga%3BRice%2C+Carol%3BDosemeci%2C+Mustafa&rft.aulast=Baccarelli&rft.aufirst=Andrea&rft.date=2006-01-01&rft.volume=49&rft.issue=6&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20316 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inhalation; Smoking; Fibers; Occupational exposure; Dust; Lung cancer; Russia DO - http://dx.doi.org/10.1002/ajim.20316 ER - TY - JOUR T1 - Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: Production of hepatocellular carcinoma at clinically relevant doses AN - 17175227; 6837527 AB - Metallothionein (MT) is a high-affinity metal binding protein thought to mitigate the toxicity of various metals. Cisplatin is a widely used cancer chemotherapeutic that is a rodent carcinogen and may have carcinogenic potential in humans. MT seems to reduce cisplatin toxicity by binding the metal compound but how MT deficiency might impact the carcinogenic effects of cisplatin is unknown. Thus, groups (n = 25) of male MT-I/II double knockout (MT-null) or MT wild-type (WT) mice were exposed to a single treatment of cisplatin (5 or 10 mg/kg, i.p.), or left untreated (control) and observed over the next 104 weeks. The doses of cisplatin used equate to only a fraction of the total dose used typically in clinical settings. In cisplatin-treated MT-null mice, a dose- related increase in hepatocellular carcinoma (HCC) occurred (control, 0%; 5 mg/kg, 17%; 10 mg/kg, 36%) that was not seen in WT mice. Similarly, liver carcinoma multiplicity (HCC/liver) was increased markedly by cisplatin but only in MT-null mice, indicating the formation of multiple primaries in MT deficient mice. Harderian gland carcinoma incidence was also increased by cisplatin treatment in MT-null mice but not WT mice. Our results indicate that MT-null mice are hypersusceptible to the hepatocarcinogenic effects of cisplatin, and poor MT expression may be a predisposing factor for cisplatin-induced secondary tumors after chemotherapy. JF - International Journal of Cancer AU - Waalkes, Michael P AU - Liu, Jie AU - Kasprzak, Kazimierz S AU - Diwan, Bhalchandra A AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, waalkes@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 28 EP - 32 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 1 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts KW - cisplatin KW - carcinogenesis KW - mice KW - metallothionein KW - Metals KW - Cisplatin KW - Metallothionein KW - Carcinogenicity KW - Harderian gland KW - Chemotherapy KW - Carcinogens KW - Carcinoma KW - Hepatocellular carcinoma KW - X 24164:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17175227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Hypersusceptibility+to+cisplatin+carcinogenicity+in+metallothionein-I%2FII+double+knockout+mice%3A+Production+of+hepatocellular+carcinoma+at+clinically+relevant+doses&rft.au=Waalkes%2C+Michael+P%3BLiu%2C+Jie%3BKasprzak%2C+Kazimierz+S%3BDiwan%2C+Bhalchandra+A&rft.aulast=Waalkes&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=119&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Metallothionein; Cisplatin; Carcinogenicity; Chemotherapy; Harderian gland; Carcinogens; Hepatocellular carcinoma; Carcinoma DO - http://dx.doi.org/10.1002/ijc.21245 ER - TY - JOUR T1 - Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high-risk region in China AN - 17166920; 6838444 AB - Each year, esophageal and gastric cancers cause more than 900,000 deaths worldwide. Human papilloma virus (HPV), especially type 16, has been suggested to have a role in the etiology of esophageal cancer, however, the results of previous seroepidemiological studies have not been consistent. We conducted a large prospective study to examine the association between serum antibodies to HPV 16, HPV 18 and HPV 73 and subsequent development of esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and gastric noncardia adenocarcinoma (GNCA) in a high-risk population for these cancers in Linxian, China. Case and control subjects for this study were selected from the 29,584 participants of the Linxian General Population Trial. Prediagnostic serum samples from 99 cases of ESCC, 100 cases of GCA, 70 cases of GNCA, and 381 age- and sex- matched controls were selected for this study. The presence of antibodies to HPV virus-like particles was determined by type-specific enzyme- linked immunosorbent assays. Fewer than 15% of ESCC, GCA, or GNCA cases were positive for each HPV type, and no significant associations were found. The adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for HPV 16 seropositivity and ESCC, GCA, and GNCA risk were 1.6 (0.8-3.3), 1.3 (0.6-2.8) and 0.4 (0.1-1.6), respectively. The comparable ORs (95% CIs) for HPV 18 were 1.0 (0.4-2.2), 0.9 (0.4-2.1) and 1.5 (0.6-3.4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China. JF - International Journal of Cancer AU - Kamangar, Farin AU - Qiao, You-Lin AU - Schiller, John T AU - Dawsey, Sanford M AU - Fears, Thomas AU - Sun, Xui-Di AU - Abnet, Christian C AU - Zhao, Ping AU - Taylor, Philip R AU - Mark, Steven D AD - Division of Cancer Epidemiology and Genetics; National Cancer Institute, Bethesda, MD, USA, kamangaf@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 579 EP - 584 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 3 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Virology & AIDS Abstracts KW - esophageal cancer KW - human papillomavirus KW - serology KW - Etiology KW - Virus-like particles KW - squamous cell carcinoma KW - Serology KW - Cancer KW - Immunosorbents KW - Antibodies KW - Risk factors KW - Risk groups KW - China, People's Rep. KW - Gastric cancer KW - Adenocarcinoma KW - Human papillomavirus KW - R2 23060:Medical and environmental health KW - V 22114:Human oncogenic viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17166920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Human+papillomavirus+serology+and+the+risk+of+esophageal+and+gastric+cancers%3A+Results+from+a+cohort+in+a+high-risk+region+in+China&rft.au=Kamangar%2C+Farin%3BQiao%2C+You-Lin%3BSchiller%2C+John+T%3BDawsey%2C+Sanford+M%3BFears%2C+Thomas%3BSun%2C+Xui-Di%3BAbnet%2C+Christian+C%3BZhao%2C+Ping%3BTaylor%2C+Philip+R%3BMark%2C+Steven+D&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2006-01-01&rft.volume=119&rft.issue=3&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21871 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Etiology; Antibodies; Virus-like particles; Risk factors; Risk groups; squamous cell carcinoma; Adenocarcinoma; Gastric cancer; Serology; Immunosorbents; Cancer; Human papillomavirus; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.21871 ER - TY - JOUR T1 - Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H sub(1) receptors AN - 17163595; 6819003 AB - Benztropine (BZT) and its analogues inhibit dopamine uptake and bind with moderate to high affinity to the dopamine transporter (DAT). However, many of these compounds, in contrast to other monoamine uptake inhibitors, lack cocaine- like behavioral effects and fail to potentiate the effects of cocaine. The BZT analogues also exhibit varied binding affinities for muscarinic M sub(1) and histamine H sub(1) receptors. In this study, a comparative analysis was conducted of pharmacophoric features with respect to the activities of BZT analogues at the DAT and at the histamine H sub(1) receptor. The BZT analogues showed a wide range of histamine H sub(1) receptor (K sub(i) = 16-37,600 nM) and DAT (K sub(i) = 8.5-6370 nM) binding affinities. A stereoselective histamine H sub(1)-antagonist pharmacophore, using a five-point superimposition of classical antagonists on the template, cyproheptadine, was developed. A series of superimpositions and comparisons were performed with various analogues of BZT. In general, smaller substituents were well tolerated on the aromatic rings of the diphenyl methoxy group for both the DAT and H sub(1) receptor, however, for the H sub(1) receptor, substitution at only one of the aromatic rings was preferred. The substituents at the 2- and N-positions of the tropane ring were preferred for DAT, however, these groups seem to overlap receptor essential regions in the histamine H sub(1) receptor. Molecular models at the DAT and the histamine H sub(1) receptor provide further insight into the structural requirements for binding affinity and selectivity that can be implemented in future drug design. JF - Bioorganic and Medicinal Chemistry AU - Kulkarni, Santosh S AU - Kopajtic, Theresa A AU - Katz, Jonathan L AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500, Nathan Shock Drive, Baltimore, MD 21224, USA, anewman@intra.nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3625 EP - 3634 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 11 SN - 0968-0896, 0968-0896 KW - benztropine KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Dopamine transporter KW - Benztropines KW - Histamine H sub(1) receptor KW - Molecular modeling KW - Cocaine KW - Pharmacophore KW - Molecular modelling KW - monoamines KW - tropane KW - Acetylcholine receptors (muscarinic) KW - Cyproheptadine KW - Drug abuse KW - Histamine H1 receptors KW - Histamine KW - Aromatics KW - pharmacophores KW - W 30965:Miscellaneous, Reviews KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17163595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Comparative+structure-activity+relationships+of+benztropine+analogues+at+the+dopamine+transporter+and+histamine+H+sub%281%29+receptors&rft.au=Kulkarni%2C+Santosh+S%3BKopajtic%2C+Theresa+A%3BKatz%2C+Jonathan+L%3BNewman%2C+Amy+Hauck&rft.aulast=Kulkarni&rft.aufirst=Santosh&rft.date=2006-01-01&rft.volume=14&rft.issue=11&rft.spage=3625&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.01.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; tropane; monoamines; Dopamine transporter; Acetylcholine receptors (muscarinic); Cyproheptadine; Drug abuse; Cocaine; pharmacophores; Aromatics; Histamine H1 receptors; Histamine DO - http://dx.doi.org/10.1016/j.bmc.2006.01.017 ER - TY - JOUR T1 - Posttranscriptional Derepression of GADD45 alpha by Genotoxic Stress AN - 17162911; 6821474 AB - The growth arrest- and DNA damage-inducible gene GADD45 alpha is potently upregulated in response to stress stimuli. Here, two RNA binding proteins, the mRNA decay-promoting AUF1 and the translational suppressor TIAR, were found to interact specifically with the 3' untranslated region (UTR) of the GADD45 alpha mRNA in HeLa cells. These associations were prominent in unstimulated cells, decreasing dramatically after treatment with the genotoxin methyl methanesulfonate (MMS). Analysis of both endogenous and chimeric GADD45 alpha mRNA revealed that in untreated cells AUF1 strongly reduced GADD45 alpha mRNA stability, whereas TIAR potently inhibited GADD45 alpha translation. After genotoxic stress, AUF1 and TIAR dissociated from the GADD45 alpha mRNA, thereby allowing coordinated elevations in both GADD45 alpha mRNA half-life and translation rate, respectively. We propose that the posttranscriptional derepression of GADD45 alpha critically contributes to its potent upregulation after DNA damage. JF - Molecular Cell AU - Lal, Ashish AU - Abdelmohsen, Kotb AU - Pullmann, Rudolf AU - Kawai, Tomoko AU - Galban, Stefanie AU - Yang, Xiaoling AU - Brewer, Gary AU - Gorospe, Myriam AD - Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, ashishl@grc.nia.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 117 EP - 128 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 22 IS - 1 SN - 1097-2765, 1097-2765 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - DNA KW - RNA External Links KW - Methyl methanesulfonate KW - Gadd45A protein KW - Translation KW - DNA damage KW - mRNA stability KW - RNA-binding protein KW - Genotoxicity KW - Derepression KW - Stress KW - Post-transcription KW - GADD45A protein KW - X 24240:Miscellaneous KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17162911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=Posttranscriptional+Derepression+of+GADD45+alpha+by+Genotoxic+Stress&rft.au=Lal%2C+Ashish%3BAbdelmohsen%2C+Kotb%3BPullmann%2C+Rudolf%3BKawai%2C+Tomoko%3BGalban%2C+Stefanie%3BYang%2C+Xiaoling%3BBrewer%2C+Gary%3BGorospe%2C+Myriam&rft.aulast=Lal&rft.aufirst=Ashish&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Molecular+Cell&rft.issn=10972765&rft_id=info:doi/10.1016%2Fj.molcel.2006.03.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Methyl methanesulfonate; DNA damage; Translation; Gadd45A protein; mRNA stability; RNA-binding protein; Genotoxicity; Derepression; Stress; Post-transcription; GADD45A protein DO - http://dx.doi.org/10.1016/j.molcel.2006.03.016 ER - TY - JOUR T1 - Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2- trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter AN - 17149523; 6819038 AB - A series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the N-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined. One analogue, 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2- trifluoromethylbenzyl)piperidine (the C sub(2)-trifluoromethyl substituted compound), has been found to act as an allosteric modulator of hSERT binding and function. It had little affinity for any of the transporters. Several compounds showed affinity for the DAT in the low nanomolar range and displayed a broad range of SERT/DAT selectivity ratios and very little affinity for the NET. The pharmacological tools provided by the availability of compounds with varying transporter affinity and selectivity could be used to obtain additional information about the properties a compound should have to act as a useful pharmacotherapeutic agent for cocaine addiction and help unravel the pharmacological mechanisms relevant to stimulant abuse. JF - Bioorganic and Medicinal Chemistry AU - Boos, Terrence L AU - Greiner, Elisabeth AU - Calhoun, WJason AU - Prisinzano, Thomas E AU - Nightingale, Barbara AU - Dersch, Christina M AU - Rothman, Richard B AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Laboratory of Medicinal Chemistry, Building 8, Room B1-23, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, kr21f@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3967 EP - 3973 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 11 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - N-Benzyl GBR analogue synthesis KW - SAR KW - Allosteric inhibitor KW - DAT, SERT, NET transporters KW - Cocaine treatment agent KW - Dopamine transporter KW - Piperidine KW - Norepinephrine transporter KW - Pharmacology KW - Allosteric properties KW - Stimulants KW - Serotonin transporter KW - Drug addiction KW - Cocaine KW - Structure-activity relationships KW - Aromatics KW - W 30965:Miscellaneous, Reviews KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17149523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Structure-activity+relationships+of+substituted+N-benzyl+piperidines+in+the+GBR+series%3A+Synthesis+of+4-%282-%28bis%284-fluorophenyl%29methoxy%29ethyl%29-1-%282-+trifluoromethylbenzyl%29piperidine%2C+an+allosteric+modulator+of+the+serotonin+transporter&rft.au=Boos%2C+Terrence+L%3BGreiner%2C+Elisabeth%3BCalhoun%2C+WJason%3BPrisinzano%2C+Thomas+E%3BNightingale%2C+Barbara%3BDersch%2C+Christina+M%3BRothman%2C+Richard+B%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Boos&rft.aufirst=Terrence&rft.date=2006-01-01&rft.volume=14&rft.issue=11&rft.spage=3967&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.01.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dopamine transporter; Piperidine; Pharmacology; Norepinephrine transporter; Allosteric properties; Stimulants; Cocaine; Drug addiction; Serotonin transporter; Structure-activity relationships; Aromatics DO - http://dx.doi.org/10.1016/j.bmc.2006.01.065 ER - TY - JOUR T1 - Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3- trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635 AN - 17148601; 6819014 AB - Radioligands that are specific for the serotonin 5-HT sub(1A) receptor will be useful in characterizing the physiological action of this receptor subtype. With radioligands of varying pharmacokinetic properties, investigators can measure not only receptor density, but also the effect of endogenous serotonin concentration. To this end, three additional fluorinated analogs of WAY 100635 were prepared and evaluated as 5-HT sub(1A) receptor ligands of varying pharmacokinetic properties based on our previous studies. These four compounds are cis-4-fluoro-, trans-4-fluoro-, cis-3-fluoro-, and trans-3- fluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2 - yl)cyclohexanecarboxamides (FCWAYs). All four compounds were characterized and radiolabeled with fluorine-18, a 109.7 min half-life radionuclide used in positron emission tomography. We then determined in vitro inhibition constants at the 5-HT sub(1A) receptor; in vitro metabolic profile, using rat hepatocytes and liquid chromatography/mass spectroscopy (LC/MS); and the rate of defluorination and hippocampus to cerebellum ratio ex vivo. This led to the conclusion that high affinity 4-trans-F-18 FCWAY had the best properties for measuring receptor density given its high hippocampus to cerebellum ratio and 3- cis-F-18 FCWAY had the best properties for measuring dynamic change in receptors, with lower affinity and faster pharmacokinetics. JF - Bioorganic and Medicinal Chemistry AU - Lang, Lixin AU - Jagoda, Elaine AU - Ma, Ying AU - Sassaman, Mark B AU - Eckelman, William C AD - PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA, llang@mail.cc.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3737 EP - 3748 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 11 SN - 0968-0896, 0968-0896 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Receptor mechanisms KW - Hepatocytes KW - Hippocampus KW - Cerebellum KW - Pharmacokinetics KW - Serotonin S1 receptors KW - Liquid chromatography KW - Radioisotopes KW - Positron emission tomography KW - Receptor density KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17148601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+in+vivo+biodistribution+of+F-18+labeled+3-cis-%2C+3-+trans-%2C+4-cis-%2C+and+4-trans-fluorocyclohexane+derivatives+of+WAY+100635&rft.au=Lang%2C+Lixin%3BJagoda%2C+Elaine%3BMa%2C+Ying%3BSassaman%2C+Mark+B%3BEckelman%2C+William+C&rft.aulast=Lang&rft.aufirst=Lixin&rft.date=2006-01-01&rft.volume=14&rft.issue=11&rft.spage=3737&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.01.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Serotonin S1 receptors; Pharmacokinetics; Hippocampus; Receptor mechanisms; Receptor density; Cerebellum; Hepatocytes; Liquid chromatography; Positron emission tomography; Radioisotopes DO - http://dx.doi.org/10.1016/j.bmc.2006.01.064 ER - TY - JOUR T1 - New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity AN - 17148208; 6819084 AB - We synthesized, separated into enantiomers, and tested for the HIV-1 reverse transcriptase inhibitory activity a group of analogs of dimethyl-1-(1- piperidynyl)cyclobuta[b][1]benzothiophene-2,2a(7bH)-dicarboxylate (NSC- 380292). Absolute configurations of the enantiomers were determined based on absolute X-ray structures and analysis of CD spectra. Within pairs of enantiomers the (R,R)-enantiomer was always much more potent HIV-1 reverse transcriptase inhibitor. JF - Bioorganic and Medicinal Chemistry Letters AU - Krajewski, Krzysztof AU - Zhang, Yijun AU - Parrish, Damon AU - Deschamps, Jeffrey AU - Roller, Peter P AU - Pathak, Vinay K AD - Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA, proll@helix.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3034 EP - 3038 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 11 SN - 0960-894X, 0960-894X KW - HIV-1 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Reverse transcriptase inhibitors KW - Synthesis KW - Chiral separation KW - CD spectra KW - X-ray structures KW - RT inhibitory assay KW - X-ray crystallography KW - Enantiomers KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - RNA-directed DNA polymerase KW - Absolute configuration KW - scaffolds KW - A 01068:Antiviral & viricidal KW - W3 33372:Antiviral agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17148208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=New+HIV-1+reverse+transcriptase+inhibitors+based+on+a+tricyclic+benzothiophene+scaffold%3A+Synthesis%2C+resolution%2C+and+inhibitory+activity&rft.au=Krajewski%2C+Krzysztof%3BZhang%2C+Yijun%3BParrish%2C+Damon%3BDeschamps%2C+Jeffrey%3BRoller%2C+Peter+P%3BPathak%2C+Vinay+K&rft.aulast=Krajewski&rft.aufirst=Krzysztof&rft.date=2006-01-01&rft.volume=16&rft.issue=11&rft.spage=3034&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.02.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - X-ray crystallography; Antiviral agents; Enantiomers; RNA-directed DNA polymerase; Absolute configuration; scaffolds; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmcl.2006.02.049 ER - TY - JOUR T1 - Synthesis and structure-activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB sub(1)) receptor ligands for potential use in molecular imaging AN - 17147705; 6819012 AB - Cannabinoid type-1 (CB sub(1)) receptor ligands, derived from the 1,5- diarylpyrazole core template of rimonabant (Acomplia super([registered])), have been the focus of several studies aimed at examining structure-activity relationships (SARs). The purpose of this study was to design and synthesize a set of compounds based on the 1,5-diarylpyrazole template while focusing on the potential for discovery of CB sub(1) receptor radioligands that might be used as probes with in vivo molecular imaging. Each synthesized ligand was evaluated for potency as an antagonist at CB sub(1) and cannabinoid type-2 (CB sub(2)) receptors in vitro using a GTP gamma super(35)S-binding assay. c log P values were calculated with Pallas 3.0. The antagonist binding affinities (K sub(B)) at CB sub(1) receptors ranged from 11 to >16,000 nM, CB sub(1) versus CB sub(2) selectivities from 0.6 to 773, and c log Ps from 3.61 to 6.25. An interesting new ligand, namely N-(piperidin-1-yl)-1-(2-bromophenyl)-5-(4-methoxyphenyl)-4-methyl- 1H-pyrazole-3-carboxamide (9j), emerged from the synthesized set with appealing properties (K sub(B) = 11 nM; CB sub(1) selectivity > 773; c log P = 5.85), for labeling with carbon-11 and development as a radioligand for imaging brain CB sub(1) receptors in vivo with positron emission tomography (PET). JF - Bioorganic and Medicinal Chemistry AU - Donohue, Sean R AU - Halldin, Christer AU - Pike, Victor W AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, donohues@intra.nimh.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3712 EP - 3720 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 11 SN - 0968-0896, 0968-0896 KW - Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - CB sub(1) receptor KW - PET KW - 1,5-Diarylpyrazoles KW - Carbon-11 KW - NIDA 41087 KW - Rimonabant KW - Molecular modelling KW - Neuroimaging KW - Cannabinoid CB2 receptors KW - Positron emission tomography KW - Probes KW - Cannabinoid CB1 receptors KW - Structure-activity relationships KW - W 30910:Imaging KW - V 22410:Animal Diseases KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17147705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+structure-activity+relationships+%28SARs%29+of+1%2C5-diarylpyrazole+cannabinoid+type-1+%28CB+sub%281%29%29+receptor+ligands+for+potential+use+in+molecular+imaging&rft.au=Donohue%2C+Sean+R%3BHalldin%2C+Christer%3BPike%2C+Victor+W&rft.aulast=Donohue&rft.aufirst=Sean&rft.date=2006-01-01&rft.volume=14&rft.issue=11&rft.spage=3712&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.01.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Neuroimaging; Cannabinoid CB2 receptors; Probes; Positron emission tomography; Cannabinoid CB1 receptors; Structure-activity relationships DO - http://dx.doi.org/10.1016/j.bmc.2006.01.047 ER - TY - JOUR T1 - Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: A population-based case-control study AN - 17109108; 6736177 AB - A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden (1958-1998), with linkable relatives, 16,543 matched controls and first-degree relatives of cases (n = 22,490) and controls (n = 44,436). Odds ratios (ORs) were calculated to quantify the risk of MM in relation to personal/family history of 32 autoimmune disorders. Familial aggregation of malignancies was evaluated in a marginal survival model using relatives as the cohort. The risk for MM was significantly elevated among subjects with a personal history of pernicious anemia (OR = 3.27; 2.22-4.83) and individuals with a family history of systemic lupus erythematosus (OR = 2.66; 1.12-6.32). Compared with controls, relative risk (RR) of MM was significantly increased (RR = 1.67; 1.02-2.73) in relatives of cases, particularly relatives of probands aged [ge]65 at diagnosis (RR = 2.50; 1.19-5.27). Risks were nearly 4-fold elevated among female relatives (RR = 3.97; 1.54-10.2) and among relatives of female probands (RR = 3.74; 1.58-8.83). MM cases had more cases of monoclonal gammopathy of undetermined significance (MGUS) among their relatives than controls, but the numbers were too small to be conclusive. There was generally no increase in risk of MM in probands whose relatives had hematologic malignancies other than MM. These findings do not support a strong association between personal/familial autoimmune diseases and MM. However, MM itself shows significant familial aggregation, implicating the etiologic importance of this type of hematological neoplasm and perhaps MGUS in germ line genes. JF - International Journal of Cancer AU - Landgren, Ola AU - Linet, Martha S AU - McMaster, Mary L AU - Gridley, Gloria AU - Hemminki, Kari AU - Goldin, Lynn R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, landgreo@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3095 EP - 3098 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - autoimmune diseases KW - multiple myeloma KW - Risk Abstracts KW - hematopoietic malignancies multiple myeloma autoimmune disease family history familial aggregation KW - Historical account KW - Genetics KW - Cancer KW - Sweden KW - Family studies KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17109108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Familial+characteristics+of+autoimmune+and+hematologic+disorders+in+8%2C406+multiple+myeloma+patients%3A+A+population-based+case-control+study&rft.au=Landgren%2C+Ola%3BLinet%2C+Martha+S%3BMcMaster%2C+Mary+L%3BGridley%2C+Gloria%3BHemminki%2C+Kari%3BGoldin%2C+Lynn+R&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3095&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21745 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genetics; Historical account; Cancer; Family studies; Sweden DO - http://dx.doi.org/10.1002/ijc.21745 ER - TY - JOUR T1 - Iron and colorectal cancer risk in the [alpha]-tocopherol, [beta]-carotene cancer prevention study AN - 17106842; 6736184 AB - In vitro and in vivo studies have associated iron with both the initiation and promotional stages of carcinogenesis. We investigated whether iron was associated with colorectal cancer in a nested case-control study within the [alpha]-tocopherol, [beta]-carotene cancer prevention study cohort. Exposure was assessed at baseline, using a 276-item food frequency questionnaire and a fasting serum sample. The study included 130 colorectal cancer cases (73 colon cancers and 57 rectal cancers) and 260 controls. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Supplemental iron intake was only reported for 4 cases and 18 controls; therefore, we were unable to obtain meaningful results for this variable. Comparing the highest to the lowest quartiles, there was an inverse association between serum ferritin and colorectal cancer risk (OR = 0.4, 95% CI = 0.2-0.9) and a suggestion of an inverse association between dietary iron and colorectal cancer risk (OR = 0.4, 95% CI = 0.1-1.1). In addition, serum ferritin, serum iron and transferrin saturation were all inversely associated with colon cancer risk specifically (OR = 0.2, 95% CI = 0.1-0.7, p trend = 0.02; OR = 0.2, 95% CI = 0.1-0.9, p trend = 0.05; OR = 0.1, 95% CI = 0.02-0.5, p trend = 0.003, respectively), whereas serum unsaturated iron binding capacity was positively associated with colon cancer risk (OR = 4.7, 95% CI = 1.4-15.1, p trend = 0.009). In summary, we found a significant inverse association between several serum iron indices and colon cancer risk. JF - International Journal of Cancer AU - Cross, Amanda J AU - Gunter, Marc J AU - Wood, Richard J AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA, crossa@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3147 EP - 3152 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - colorectal carcinoma KW - Risk Abstracts KW - red meat iron colorectal cancer KW - Diets KW - Prevention KW - Nutrition KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Iron+and+colorectal+cancer+risk+in+the+%5Balpha%5D-tocopherol%2C+%5Bbeta%5D-carotene+cancer+prevention+study&rft.au=Cross%2C+Amanda+J%3BGunter%2C+Marc+J%3BWood%2C+Richard+J%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3147&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21780 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Prevention; Nutrition; Cancer DO - http://dx.doi.org/10.1002/ijc.21780 ER - TY - JOUR T1 - Tea drinking and the risk of biliary tract cancers and biliary stones: A population-based case-control study in Shanghai, China AN - 17106822; 6736176 AB - Biliary tract cancers, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Apart from gallstones, etiologic factors for biliary tract cancer are not clearly defined. Several epidemiologic studies have suggested that consumption of tea, especially green tea, is protective against a variety of cancers, including gastrointestinal malignancies. As part of a large population-based case-control study of biliary tract disease in Shanghai, China, we evaluated the effects of tea consumption on the risk of biliary tract cancers and biliary stones. The study included 627 incident cases with biliary tract cancer, 1,037 cases with biliary stones and 959 randomly selected controls. Study subjects were interviewed to ascertain data on demographic, medical and dietary factors, including tea consumption. Forty-one percent of the controls were ever tea drinkers, defined as those who consumed at least 1 cup of tea per day for at least 6 months. After adjustment for age, education and body mass index, among women, ever tea drinkers had significantly reduced risks of biliary stones (OR = 0.73, 95% CI = 0.54-0.98) and gallbladder cancer (OR = 0.56, 95% CI = 0.38- 0.83). The inverse relationship between tea consumption and gallbladder cancer risk was independent of gallstone disease. Among men, tea drinkers were more likely to be cigarette smokers, and the risk estimates were generally below 1.0, but were not statistically significant. Further studies are needed to confirm these results in other populations and clarify the hormonal and other mechanisms that may be involved. JF - International Journal of Cancer AU - Zhang, Xue-Hong AU - Andreotti, Gabriella AU - Gao, Yu-Tang AU - Deng, Jie AU - Liu, Enju AU - Rashid, Asif AU - Wu, Kai AU - Sun, Lu AU - Sakoda, Lori C AU - Cheng, Jia-Rong AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Gridley, Gloria AU - Fraumeni, Joseph F AU - Hsing, Ann W AD - Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China, hsinga@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3089 EP - 3094 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - biliary tract KW - tea KW - Risk Abstracts KW - biliary tract cancers gallstones tea consumption polyphenol epidemiology KW - Diets KW - China, People's Rep., Shanghai KW - Risk reduction KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Tea+drinking+and+the+risk+of+biliary+tract+cancers+and+biliary+stones%3A+A+population-based+case-control+study+in+Shanghai%2C+China&rft.au=Zhang%2C+Xue-Hong%3BAndreotti%2C+Gabriella%3BGao%2C+Yu-Tang%3BDeng%2C+Jie%3BLiu%2C+Enju%3BRashid%2C+Asif%3BWu%2C+Kai%3BSun%2C+Lu%3BSakoda%2C+Lori+C%3BCheng%2C+Jia-Rong%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BGridley%2C+Gloria%3BFraumeni%2C+Joseph+F%3BHsing%2C+Ann+W&rft.aulast=Zhang&rft.aufirst=Xue-Hong&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3089&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Risk reduction; Cancer; China, People's Rep., Shanghai DO - http://dx.doi.org/10.1002/ijc.21748 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study AN - 17106507; 6736180 AB - Metolachlor is one of the most widely used herbicides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to metolachlor in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. A total of 50,193 pesticide applicators were included. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997; average length of follow-up was 7.33 years. Two metolachlor exposure metrics were used : (i) lifetime days personally mixed or applied metolachlor and (ii) intensity-weighted lifetime days (lifetime days X an intensity level). Poisson regression analysis was used to estimate relative risks (RR) and 95% confidence intervals (95%CI) for cancer subtypes by tertiles of metolachlor exposure. No clear risk for any cancer subtype was found for exposure to metolachlor. A significantly decreased RR was found for prostate cancer in the highest category of lifetime days exposure (RR = 0.59; 95%CI, 0.39-0.89) and in the second highest category of intensity- weighted lifetime days exposure (RR = 0.66; 95%CI, 0.45-0.97); however, the test for trend was not significant for either exposure metric. A nonsignificantly increased risk was found for lung cancer with lifetime days exposure in the highest category (RR = 2.37; 95%CI, 0.97-5.82, p-trend = 0.03) but not with intensity-weighted lifetime days. Given the widespread use of metolachlor and the frequent detection of metolachlor in both surface and ground water, future analyses of the AHS will allow further examination of long-term health effects, including lung cancer and the less common cancers. JF - International Journal of Cancer AU - Rusiecki, Jennifer A AU - Hou, Lifang AU - Lee, Won Jin AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Lubin, Jay H AU - Bonner, Matthew AU - Samanic, Claudine AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael CR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA, usiecki@usuhs.mil Y1 - 2006 PY - 2006 DA - 2006 SP - 3118 EP - 3123 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - metolachlor cancer pesticides herbicides applicators KW - Metolachlor KW - Risk assessment KW - Agriculture KW - USA, North Carolina KW - Herbicides KW - Agrochemicals KW - Prostate cancer KW - USA, Iowa KW - Pesticides KW - Regression analysis KW - Ground water KW - Groundwater KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - X 24134:Pathology KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17106507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+metolachlor+in+the+Agricultural+Health+Study&rft.au=Rusiecki%2C+Jennifer+A%3BHou%2C+Lifang%3BLee%2C+Won+Jin%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay+H%3BBonner%2C+Matthew%3BSamanic%2C+Claudine%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+CR&rft.aulast=Rusiecki&rft.aufirst=Jennifer&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3118&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21758 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Agriculture; Risk assessment; Metolachlor; Prostate cancer; Pesticides; Ground water; Regression analysis; Herbicides; Occupational exposure; Lung cancer; Groundwater; Agrochemicals; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1002/ijc.21758 ER - TY - JOUR T1 - Chronic exposure to dioxin-like compounds and thyroid function among New York anglers AN - 17105747; 6735670 AB - Experimental studies suggest that dioxin-like compounds influence thyroid function, although human studies have presented equivocal results. Great Lakes sportfish consumers represent a population with greater potential for exposure to dioxin-like compounds than non-consumers. Thirty-eight licensed anglers participating in a dioxin exposure study, consumers and non-consumers, conducted as part of the New York Angler Cohort Study, donated blood and completed questionnaires regarding demographic, clinical, and sportfish consumption data. Sera were analyzed for polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), coplanar biphenyls (PCB), and PCB IUPAC #153, in addition to thyroid stimulating hormone (TSH), total and free thyroxine (T sub(4) and fT sub(4)), total triiodothyronine (T sub(3)), and lipids. An inverse linear association between serum fT sub(4) and the sum of dioxin-like congener concentrations ([sigma]DIOXs) in serum (B = -0.3, 95% CI = -0.5, -0.1) was identified adjusting for PCB #153 and serum lipids (R super(2) = 0.3, p = 0.02, n = 37). The results of this study are preliminary but suggest an inverse association between dioxin-like compounds and fT sub(4). JF - Environmental Toxicology and Pharmacology AU - Bloom, Michael AU - Vena, John AU - Olson, James AU - Moysich, Kirsten AD - Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, 3435 Main St., Buffalo, NY 14214, USA, bloomm@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 260 EP - 267 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 21 IS - 3 SN - 1382-6689, 1382-6689 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Dioxins KW - fT sub(4) KW - Thyroid KW - Sportfish KW - TCDD KW - TEQ KW - Lipids KW - Serum lipids KW - Environmental health KW - Hormones KW - Demography KW - Thyroid hormones KW - Lakes KW - Chronic exposure KW - Thyroxine KW - Congeners KW - Consumers KW - Seafood KW - Thyroid-stimulating hormone KW - PCB compounds KW - PCDD KW - PCB KW - Triiodothyronine KW - Food contamination KW - USA, New York KW - Blood levels KW - Biphenyl KW - Blood KW - polychlorinated biphenyls KW - Dibenzofuran KW - Dibenzo-p-dioxin KW - Dioxin KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17105747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Chronic+exposure+to+dioxin-like+compounds+and+thyroid+function+among+New+York+anglers&rft.au=Bloom%2C+Michael%3BVena%2C+John%3BOlson%2C+James%3BMoysich%2C+Kirsten&rft.aulast=Bloom&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=21&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2005.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Serum lipids; Lipids; Thyroid; Triiodothyronine; Hormones; Demography; Biphenyl; Thyroid hormones; Blood; polychlorinated biphenyls; Dibenzofuran; Chronic exposure; Dibenzo-p-dioxin; Thyroxine; Congeners; Consumers; Thyroid-stimulating hormone; Dioxin; PCB; Lakes; Environmental health; Seafood; Food contamination; PCB compounds; PCDD; Blood levels; USA, New York DO - http://dx.doi.org/10.1016/j.etap.2005.09.001 ER - TY - JOUR T1 - APE1 genotype and risk of bladder cancer: Evidence for effect modification by smoking AN - 17104612; 6736187 AB - Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T[rarr]G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an association that was modified by cigarette smoking. To explore the association between APE1 genotype, smoking and bladder cancer risk, we examined data from an existing case-control study of bladder cancer patients (n = 239) and control individuals (n = 215) recruited from urology clinics at 2 hospitals in North Carolina. Genotype at the polymorphic site was determined using allele-specific primer extension reactions, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. We found no overall association between APE1 genotype and bladder cancer risk. In stratified analyses, however, a positive association with risk was observed with an increasing number of Glu alleles among never smokers, but not among smokers (p-value for interaction = 0.005). We can speculate that small allelic differences that are apparent in never smokers are obscured by the large amount of DNA damage found in smokers. Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously. Published 2006 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Terry, Paul D AU - Umbach, David M AU - Taylor, Jack A AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA, taylor@niehs.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 3170 EP - 3173 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 12 SN - 0020-7136, 0020-7136 KW - urinary bladder KW - Risk Abstracts KW - bladder neoplasms apurinic endonuclease polymorphism smoking case- control studies KW - Cytotoxicity KW - Cigarette smoking KW - DNA KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17104612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=APE1+genotype+and+risk+of+bladder+cancer%3A+Evidence+for+effect+modification+by+smoking&rft.au=Terry%2C+Paul+D%3BUmbach%2C+David+M%3BTaylor%2C+Jack+A&rft.aulast=Terry&rft.aufirst=Paul&rft.date=2006-01-01&rft.volume=118&rft.issue=12&rft.spage=3170&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21768 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Cigarette smoking; DNA; Cancer; Lung cancer DO - http://dx.doi.org/10.1002/ijc.21768 ER - TY - JOUR T1 - Racial Differences in Correlates of Misreporting of Energy Intake in Adolescent Females AN - 17088538; 6717881 AB - OBJECTIVE: To determine the extent of misreporting of energy intake (EI) and its anthropometric, demographic, and psychosocial correlates in a bi-racial cohort of young women. RESEARCH METHODS AND PROCEDURES: This was a cross-sectional study of 60 black and 60 white young women, 18 to 21 years old, enrolled in a longitudinal study. Total energy expenditure was assessed using doubly labeled water. Self-reported EI was obtained from 3-day food records. BMI was computed from height and weight. Fat mass was assessed by DXA. Multivariate analyses examined racial differences on the extent of misreporting and its effect on other potential correlates of misreporting. Race-specific step-wise linear regression analysis was performed to examine the effect of BMI, parental education, and drive for thinness on misreporting of EI. RESULTS: More white women tended to under-report EI than black women (22% vs. 13%, p = 0.07). In black women, under-reporting was significantly (p = 0.01) associated with drive for thinness score but was only marginally (p = 0.1) associated with BMI. Each point increase in drive for thinness score was associated with under-reporting by 40 kcal/d. In white women, under-reporting was significantly (p = 0.03) associated with higher parental education by 440 kcal/d and also only marginally (p = 0.09) with BMI. DISCUSSION: This tendency for under-reporting of EI limits the use of self-reported EI in studying energy balance in free-living subjects. Most black and almost all white women in their late teens significantly under-reported their EI, whereas under-reporting was not as evident among lean young black women. JF - Obesity Research AU - Kimm, Sue YS AU - Glynn, Nancy W AU - Obarzanek, Eva AU - Aston, Christopher E AU - Daniels, Stephen R AD - Department of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma. Division of Cardiology, Cincinnati Children's Hospital, Cincinnati, Ohio Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 156 EP - 164 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 1 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Longitudinal studies KW - Obesity KW - Blacks KW - Adolescence KW - Women KW - Height KW - Demographics KW - Water KW - scoring KW - Ethnic differences KW - Energy cost KW - Weight KW - Analysis KW - Higher education KW - Psychosocial factors KW - Diet KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17088538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Racial+Differences+in+Correlates+of+Misreporting+of+Energy+Intake+in+Adolescent+Females&rft.au=Kimm%2C+Sue+YS%3BGlynn%2C+Nancy+W%3BObarzanek%2C+Eva%3BAston%2C+Christopher+E%3BDaniels%2C+Stephen+R&rft.aulast=Kimm&rft.aufirst=Sue&rft.date=2006-01-01&rft.volume=14&rft.issue=1&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Obesity; Blacks; Adolescence; Women; Height; Water; Demographics; scoring; Energy cost; Ethnic differences; Weight; Analysis; Higher education; Diet; Psychosocial factors; Youth ER - TY - JOUR T1 - Metabolism and disposition of 2,2',4,4'-tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice AN - 17086530; 6726469 AB - The metabolism and disposition of super(14)C-labelled 2,2'4,4'-tetrabromodiphenyl ether (BDE47) were investigated in F344 rats and B6C3F1 mice. Approximately 75-85% of 1? mu mol BDE47?kg super(-1) was absorbed following oral administration to either rats or mice. Sex and species differences were observed in tissue distribution and excretion of BDE47-derived radioactivity. Absorption and distribution of super(14)C to major tissues were dose-proportional in male rats from 0.1 to 1000? mu mol?kg super(-1). BDE47-derived radioactivity increased in all rat and mouse tissues examined following repeated daily doses of 1? mu mol?kg super(-1). Accumulation of super(14)C in tissues of mice was less than in corresponding rat tissues. Glutathione conjugates of BDE47 were excreted in rat bile. A glucuronide and a sulfate conjugate of 2,4-dibromophenol were detected in the urine of BDE47-treated rats. BDE47 appears to induce its own metabolism. Increased formation of reactive metabolites over time may correlate with toxicological effects in BDE47-treated rodents. JF - Xenobiotica AU - Sanders, J M AU - Chen, L-J AU - Lebetkin, E H AU - Burka, L T AD - Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 103 EP - 117 VL - 36 IS - 1 SN - 0049-8254, 0049-8254 KW - 2,2'4,4'-tetrabromodiphenyl ether KW - Toxicology Abstracts KW - Urine KW - Glutathione KW - Bile KW - Oral administration KW - Disposition KW - Excretion KW - Metabolites KW - Ethers KW - Radioactivity KW - Metabolism KW - Sulfate KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17086530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Metabolism+and+disposition+of+2%2C2%27%2C4%2C4%27-tetrabromodiphenyl+ether+following+administration+of+single+or+multiple+doses+to+rats+and+mice&rft.au=Sanders%2C+J+M%3BChen%2C+L-J%3BLebetkin%2C+E+H%3BBurka%2C+L+T&rft.aulast=Sanders&rft.aufirst=J&rft.date=2006-01-01&rft.volume=36&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250500485107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Glutathione; Urine; Bile; Oral administration; Metabolites; Excretion; Disposition; Radioactivity; Ethers; Metabolism; Sulfate DO - http://dx.doi.org/10.1080/00498250500485107 ER - TY - JOUR T1 - Risk factors for HPV infection and cervical cancer among unscreened women in a high-risk rural area of China AN - 17084217; 6711822 AB - We report a prevalence rate of 23.6% human papillomavirus (HPV) infection with oncogenic subtypes and 2.4% cervical intraepithelial neoplasia (CIN) III and cervical cancer (CC) in rural middle-aged women in 2 counties with the highest CC mortality in Shanxi Province, China. We examined the association of risk factors to HPV infection and to CIN III and CC in 8,798 unscreened women aged 35-50 years. Multivariate odds ratios (OR) and 95% confidence intervals (CI) for each endpoint were obtained for risk factors after adjustment for covariates. The OR of oncogenic HPV were: 1.41 (95% CI = 1.25-1.60) and 1.42 (95% CI = 1.24-1.61) for the participant and her husband having multiple sexual partners, respectively; 1.67 (95% CI = 1.37-2.04), 1.15 (95% CI = 1.04-1.26), and 0.82 (95% CI = 0.72-0.94) for ever (vs. never) diagnosed with tuberculosis, cervical inflammation and vaginal trichomoniasis, respectively; while bathing in a public (v. private) facility had an OR of 1.23 (95% CI =1.11- 1.35). Seasonal fluctuations in HPV infection, but not CC, appeared in Xiangyuan County, with OR of 1.23 (95% CI = 1.14-1.33) and 1.51 (95% CI = 1.35-1.67) in Spring and Winter compared to Summer, respectively. The OR of CIN III and CC in the HPV positives were: 2.03 (95% CI = 1.63-2.53) for ages [ge]45 years (vs. <40); and 4.01 (95% CI = 1.46-11.0) for [ge]3 (vs. no) home births. Public health interventions and control strategies for improving the reproductive health of women in these rural populations need to be developed to reduce risk of HPV and subsequent CC. JF - International Journal of Cancer AU - Zhao, Fang-Hui AU - Forman, Michele R AU - Belinson, Jerome AU - Shen, Yan-Hong AU - Graubard, Barry I AU - Patel, Arti C AU - Rong, Shou-De AU - Pretorius, Robert G AU - Qiao, You-Lin AD - Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China, mf63p@nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 442 EP - 448 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 118 IS - 2 SN - 0020-7136, 0020-7136 KW - cervical carcinoma KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Virology & AIDS Abstracts KW - cervical cancer human papillomavirus tuberculosis trichomoniasis KW - Age KW - Mycobacterium KW - Cervical cancer KW - Infection KW - Sexual behavior KW - Neoplasia KW - Public health KW - Sexual partners KW - Risk factors KW - Risk groups KW - Trichomoniasis KW - Tuberculosis KW - Mortality KW - Rural populations KW - Inflammation KW - Birth KW - Vagina KW - China, People's Rep. KW - Females KW - Cervix KW - Human papillomavirus KW - Rural areas KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health KW - V 22114:Human oncogenic viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17084217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+factors+for+HPV+infection+and+cervical+cancer+among+unscreened+women+in+a+high-risk+rural+area+of+China&rft.au=Zhao%2C+Fang-Hui%3BForman%2C+Michele+R%3BBelinson%2C+Jerome%3BShen%2C+Yan-Hong%3BGraubard%2C+Barry+I%3BPatel%2C+Arti+C%3BRong%2C+Shou-De%3BPretorius%2C+Robert+G%3BQiao%2C+You-Lin&rft.aulast=Zhao&rft.aufirst=Fang-Hui&rft.date=2006-01-01&rft.volume=118&rft.issue=2&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Cervical cancer; Rural populations; Infection; Neoplasia; Public health; Inflammation; Birth; Sexual partners; Risk factors; Vagina; Trichomoniasis; Risk groups; Tuberculosis; Cervix; Females; Sexual behavior; Rural areas; Mycobacterium; Human papillomavirus; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.21327 ER - TY - JOUR T1 - A rotation-invariant spherical harmonic decomposition method for mapping intravoxel multiple fiber structures AN - 17083895; 6709474 AB - A new rotation-invariant spherical harmonic decomposition (SHD) method is proposed in this paper for analyzing high angular resolution diffusion (HARD) imaging. Regular SHD methods have been used to characterize the features of the apparent diffusion coefficient (ADC) profile measured by the HARD technique. However, these regular SHD methods are rotation-variant, i.e., the magnitude and/or the phase of the harmonic components changes with the rotation of the ADC profile. We propose a new rotation-invariant SHD (RI-SHD) method based on the rotation-invariant property of a diffusion tensor model. The basic idea of the proposed method is to reorient the measured ADC profile into a local coordinate system determined by the three eigenvectors of the diffusion tensor in each imaging voxel, and then apply a SHD to the ADC profile. Both simulations and in vivo experiments were carried out to validate the method. Comparisons were made between the component maps from a regular SHD method, diffusion circular spectrum mapping (DCSM) method and the proposed RI-SHD method. The results indicate that the regular SHD maps vary significantly with the rotation of the diffusion-encoding scheme, whereas the maps of the DCSM and the proposed method remain unchanged. In particular, the (0,0)-th, (2,2)-th and (4,4)-th component maps from the RI-SHD method exhibited good consistency with the 0th, 2nd and 4th order maps of the DCSM method, respectively. Compared with the regular SHD methods used in HARD imaging, the proposed RI-SHD method is superior in characterizing the diffusion patterns of multiple fiber structures between different brain regions or across subjects. JF - NeuroImage AU - Zhan, Wang AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Nathan Shock Dr. Room 383, Baltimore, MD 21224, USA, yihongyang@intra.nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1212 EP - 1223 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 29 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Fibers KW - Brain mapping KW - Neuroimaging KW - Diffusion KW - Maps KW - Decomposition KW - Methodology KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17083895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=A+rotation-invariant+spherical+harmonic+decomposition+method+for+mapping+intravoxel+multiple+fiber+structures&rft.au=Zhan%2C+Wang%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Zhan&rft.aufirst=Wang&rft.date=2006-01-01&rft.volume=29&rft.issue=4&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.08.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Diffusion; Neuroimaging; Brain mapping; Fibers; Decomposition; Maps; Methodology DO - http://dx.doi.org/10.1016/j.neuroimage.2005.08.045 ER - TY - JOUR T1 - Improved BOLD detection in the medial temporal region using parallel imaging and voxel volume reduction AN - 17081760; 6709477 AB - Using gradient-echo EPI, signal dropout due to macroscopic off resonance effects can prevent blood-oxygenation-level-dependent (BOLD) signal change detection. The anterior medial temporal lobe (MTL) is located near these susceptibility gradients and therefore shows considerable signal dropout with GE-EPI. Reducing the volume of the image voxel reduces susceptibility-related signal dropout. However, this is accompanied by a prohibitive reduction in signal-to-noise ratio (SNR). To compensate for SNR loss with smaller voxels, we used a multi-channel MRI receiver with an array of receive-only 16-element surface coils at 3 T. We demonstrate that the reduction of susceptibility artifacts, through use of high resolution images, coupled with the gains in image SNR from the array coil improves the temporal signal-to-noise ratio (TSNR) and enhances the contrast-to-noise ratio (CNR). Furthermore, a comparison of 2 mm with 4-mm-thick axial images both with the same in-plane resolution showed that thinner slices enhanced TSNR and CNR throughout the ventral-medial regions of the temporal lobes, with the greatest improvement in the most anterior regions of the MTL. Further improvements were seen when adjacent 2 mm slices were combined to match overall voxel volume. These results demonstrate that BOLD investigation of anterior MTL function can be enhanced by decreasing voxel size but only in combination with the SNR gained by using the 16-channel head coil system. JF - NeuroImage AU - Bellgowan, Patrick SF AU - Bandettini, Peter A AU - Van Gelderen, Peter AU - Martin, Alex AU - Bodurka, Jerzy AD - Section on Cognitive Neuropsychology, NIMH, 10 Center Drive, 10 Center Dr., Bldg 10 room 4C104, NIH, Bethesda, MD 20892-1366, USA, psfb@mail.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1244 EP - 1251 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 29 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Temporal lobe KW - Neuroimaging KW - Head KW - Magnetic resonance imaging KW - Image processing KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17081760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Improved+BOLD+detection+in+the+medial+temporal+region+using+parallel+imaging+and+voxel+volume+reduction&rft.au=Bellgowan%2C+Patrick+SF%3BBandettini%2C+Peter+A%3BVan+Gelderen%2C+Peter%3BMartin%2C+Alex%3BBodurka%2C+Jerzy&rft.aulast=Bellgowan&rft.aufirst=Patrick&rft.date=2006-01-01&rft.volume=29&rft.issue=4&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.08.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Temporal lobe; Neuroimaging; Magnetic resonance imaging; Image processing; Head DO - http://dx.doi.org/10.1016/j.neuroimage.2005.08.042 ER - TY - JOUR T1 - Neural Basis Subserving the Detection of Postural Instability: An fMRI Study AN - 17074222; 6700422 AB - Human upright posture is a product of a complex dynamic system that relies on integration of input from multimodal sensory sources. Extensive research has explored the role of visual, vestibular, and somatosensory systems in the control of upright posture. However, the role of higher cognitive function in a participant's assessment of postural stability has been less studied. In previous research, we showed specific neural activation patterns in EEG associated with recognition of unstable postures in young healthy participants. Similar EEG patterns have been recently observed in regulation of posture equilibrium in dynamic stances. This article evaluates participants' postural stability in dynamic stances and neural activation patterns underlying visual recognition of unstable postures using event-related functional MRI (fMRI). Our results show that the "stable" participants were successful in recognition of unstable postures of a computer-animated body model and experienced egocentric motion. Successful recognition of unstable postures in these participants induces activation of distinct areas of the brain including bilateral parietal cortex, anterior cingulate cortex, and bilateral cerebellum. In addition, significant activation is observed in basal ganglia (caudate nucleus and putamen) but only during perception of animated postures. Our findings suggest the existence of modality-specific distributed activation of brain areas responsible for detection of postural instability. JF - Motor Control AU - Slobounov, S AU - Wu, T AU - Hallett, M AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 69 EP - 89 VL - 10 IS - 1 SN - 1087-1640, 1087-1640 KW - Physical Education Index KW - Evaluation KW - Scanning KW - Perception KW - Electroencephalography KW - Brain KW - Health KW - Posture KW - Stability KW - Balance KW - Movement KW - Motor control KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17074222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Motor+Control&rft.atitle=Neural+Basis+Subserving+the+Detection+of+Postural+Instability%3A+An+fMRI+Study&rft.au=Slobounov%2C+S%3BWu%2C+T%3BHallett%2C+M&rft.aulast=Slobounov&rft.aufirst=S&rft.date=2006-01-01&rft.volume=10&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Motor+Control&rft.issn=10871640&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Evaluation; Scanning; Perception; Electroencephalography; Brain; Health; Stability; Posture; Movement; Balance; Motor control ER - TY - JOUR T1 - A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain AN - 17071849; 6695089 AB - A sensitive and specific method for the simultaneous detection and quantification of amphetamine, opiates, and cocaine and metabolites in human postmortem brain was developed and validated. Analytes of interest included amphetamine, morphine, codeine, 6-acetylmorphine, cocaine, benzoylecgonine, ecgonine methyl ester, ecgonine ethyl ester, cocaethylene, and anhydroecgonine methyl ester. The method employed ultrasonic homogenization of brain tissue in pH 4.0 sodium acetate buffer and solid phase extraction. Extracts were derivatized with N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide and N,O-bis(trimethylsilyl) trifluoroacetamide. Separation and quantification were accomplished on a bench-top positive chemical ionization capillary gas chromatograph/mass spectrometer with selected ion monitoring. Eight deuterated analogs were used as internal standards. Limits of quantification were 50 ng/g of brain. Calibration curves were linear to 1000 ng/g for anhydroecgonine methyl ester and 6-acetylmorphine, and to 2000 ng/g for all other analytes. Accuracy across the linear range of the assay ranged from 90.2 to 112.2%, and precision, as percent relative standard deviation, was less than 16.6%. Quantification of drug concentrations in brain is a useful research tool in neurobiology and in forensic and postmortem toxicology, identifying the type, relative magnitude, and recency of abused drug exposure. This method will be employed to quantify drug concentrations in human postmortem brain in support of basic and clinical research on the physiologic, biochemical, and behavioral effects of drugs in humans. JF - Journal of Mass Spectrometry AU - Lowe, Ross H AU - Barnes, Allan J AU - Lehrmann, Elin AU - Freed, William J AU - Kleinman, Joel E AU - Hyde, Thomas M AU - Herman, Mary M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 175 EP - 184 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 41 IS - 2 SN - 1076-5174, 1076-5174 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - drugs of abuse KW - GC/MS KW - brain KW - cocaine KW - opiates KW - Morphine KW - Opiates KW - Brain KW - sodium acetate KW - Metabolites KW - Drug abuse KW - Mass spectroscopy KW - Codeine KW - Standard deviation KW - Cocaethylene KW - Ultrasonics KW - Forensic science KW - Amphetamine KW - Cocaine KW - pH effects KW - Ionization KW - N3 11106:Neurobiology of drug abuse KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17071849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mass+Spectrometry&rft.atitle=A+validated+positive+chemical+ionization+GC%2FMS+method+for+the+identification+and+quantification+of+amphetamine%2C+opiates%2C+cocaine%2C+and+metabolites+in+human+postmortem+brain&rft.au=Lowe%2C+Ross+H%3BBarnes%2C+Allan+J%3BLehrmann%2C+Elin%3BFreed%2C+William+J%3BKleinman%2C+Joel+E%3BHyde%2C+Thomas+M%3BHerman%2C+Mary+M%3BHuestis%2C+Marilyn+A&rft.aulast=Lowe&rft.aufirst=Ross&rft.date=2006-01-01&rft.volume=41&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mass+Spectrometry&rft.issn=10765174&rft_id=info:doi/10.1002%2Fjms.975 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Morphine; Opiates; Brain; sodium acetate; Metabolites; Drug abuse; Codeine; Mass spectroscopy; Standard deviation; Cocaethylene; Ultrasonics; Forensic science; Amphetamine; Cocaine; Ionization; pH effects DO - http://dx.doi.org/10.1002/jms.975 ER - TY - JOUR T1 - Signalling pathways and molecular interactions of NOD1 and NOD2 AN - 17071518; 6702462 AB - The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori. Here, we focus on the molecular interactions between these NOD proteins and other intracellular molecules to elucidate the mechanisms by which NOD1 and NOD2 contribute to the maintenance of mucosal homeostasis and the induction of mucosal inflammation. JF - Nature Reviews: Immunology AU - Strober, Warren AU - Murray, Peter J AU - Kitani, Atsushi AU - Watanabe, Tomohiro AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC, 5W3940, 10 Center Drive, Bethesda, Maryland 20892, USA., wstrober@niaid.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 9 EP - 20 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 6 IS - 1 SN - 1474-1733, 1474-1733 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Helicobacter pylori KW - Crohn's disease KW - Nod1 protein KW - NOD2 protein KW - Subpopulations KW - Mucosa KW - Oligomerization KW - peptidoglycans KW - Immunity KW - Homeostasis KW - Infection KW - Inflammation KW - Reviews KW - Nod protein KW - Mutation KW - Signal transduction KW - F 06334:Inflammatory bowel: Clinical KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17071518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Immunology&rft.atitle=Signalling+pathways+and+molecular+interactions+of+NOD1+and+NOD2&rft.au=Strober%2C+Warren%3BMurray%2C+Peter+J%3BKitani%2C+Atsushi%3BWatanabe%2C+Tomohiro&rft.aulast=Strober&rft.aufirst=Warren&rft.date=2006-01-01&rft.volume=6&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Immunology&rft.issn=14741733&rft_id=info:doi/10.1038%2Fnri1747 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Crohn's disease; Nod1 protein; NOD2 protein; Subpopulations; Oligomerization; Mucosa; peptidoglycans; Homeostasis; Immunity; Infection; Inflammation; Reviews; Nod protein; Mutation; Signal transduction; Helicobacter pylori DO - http://dx.doi.org/10.1038/nri1747 ER - TY - JOUR T1 - Factors influencing immunodominance hierarchies in T sub(CD8+)-mediated antiviral responses AN - 1367491089; 18081793 AB - CD8 super(+) T-lymphocytes (T sub(CD8+)) perform a critical role in immunity against tumors and virus infections. A central feature of T sub(CD8+) immune responses is immunodominance: the observation that T sub(CD8+) responses consist of a limited collection of specificities with a structured hierarchy. These immunodominance hierarchies result from a complex combination of factors. Major roles are played by peptide binding affinity, T-cell repertoire, and antigen processing and presentation. While the bulk of our information comes from mouse model systems, an increasing number of human studies suggest that immunodominance will be even more complicated. This review outlines current knowledge of T sub(CD8+ )immunodominance to viral antigens and discusses the relevance and importance of a thorough understanding for the rational design of vaccines that elicit effective T sub(CD8+) responses. JF - Expert Review of Clinical Immunology AU - Irvine, Kari AU - Bennink, Jack AD - National Institute for Allergy & Infectious Diseases, Cell Biology Section/Viral Immunology Section, Laboratory of Viral Diseases, Room 209, Building 44 Center Drive, Bethesda, MD 20892-0440, USA., kirvine@niaid.nih.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 135 EP - 147 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 2 IS - 1 SN - 1744-666X, 1744-666X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - antigen processing KW - immunodomination KW - immunodominance KW - MHC KW - TCD8 super(+) KW - T cell repertoire KW - vaccine KW - virus KW - Animal models KW - CD8 antigen KW - Tumors KW - Immunity KW - Antigen presentation KW - Infection KW - Reviews KW - Lymphocytes T KW - Antigen processing KW - Vaccines KW - Immune response KW - Immunodominance KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367491089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Clinical+Immunology&rft.atitle=Factors+influencing+immunodominance+hierarchies+in+T+sub%28CD8%2B%29-mediated+antiviral+responses&rft.au=Irvine%2C+Kari%3BBennink%2C+Jack&rft.aulast=Irvine&rft.aufirst=Kari&rft.date=2006-01-01&rft.volume=2&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Clinical+Immunology&rft.issn=1744666X&rft_id=info:doi/10.1586%2F1744666X.2.1.135 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Number of references - 116 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Reviews; Lymphocytes T; Animal models; Antigen processing; Immunity; Tumors; Immune response; Vaccines; CD8 antigen; Infection; Antigen presentation; Immunodominance DO - http://dx.doi.org/10.1586/1744666X.2.1.135 ER -