TY - JOUR T1 - A response to information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments AN - 746200375; 12747627 AB - For gene expression data obtained from a time-course microarray experiment, Liu et al. [1] developed a new algorithm for clustering genes with similar expression profiles over time. Performance of their proposal was compared with three other methods including the order-restricted inference based methodology of Peddada et al. [2,3]. In this note we point out several inaccuracies in Liu et al. [1] and conclude that the order-restricted inference based methodology of Peddada et al. (programmed in the software ORIOGEN) indeed operates at the desired nominal Type 1 error level, an important feature of a statistical decision rule, while being computationally substantially faster than indicated by Liu et al. [1]. Application of ORIOGEN to the well-known breast cancer cell line data of Lobenhofer et al. [4] revealed that ORIOGEN software took only 21 minutes to run (using 100,000 bootstraps with p = 0.0025), substantially faster than the 72 hours found by Liu et al. [1] using Matlab. Also, based on a data simulated according to the model and parameters of simulation 1 ( sigma 2 = 1, M = 5) in [1] we found that ORIOGEN took less than 30 seconds to run in stark contrast to Liu et al. who reported that their implementation of the same algorithm in R took 2979.29 seconds. Furthermore, for the simulation studies reported in [1], unlike the claims made by Liu et al. [1], ORIOGEN always maintained the desired false positive rate. According to Figure three in Liu et al. [1] their algorithm had a false positive rate ranging approximately from 0.20 to 0.70 for the scenarios that they simulated. Our comparisons of run times indicate that the implementations of ORIOGEN's algorithm in Matlab and R by Liu et al. [1] is inefficient compared to the publicly available JAVA implementation. Our results on the false positive rate of ORIOGEN suggest some error in Figure three of Liu et al. [1], perhaps due to a programming error. JF - BMC Bioinformatics AU - Peddada, Shyamal D AU - Umbach, David M AU - Harris, Shawn F AD - Biostatistics Branch, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA Y1 - 2009/12/22/ PY - 2009 DA - 2009 Dec 22 SP - 438 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Tumor cell lines KW - Data processing KW - Statistics KW - Algorithms KW - Breast cancer KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746200375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=A+response+to+information+criterion-based+clustering+with+order-restricted+candidate+profiles+in+short+time-course+microarray+experiments&rft.au=Peddada%2C+Shyamal+D%3BUmbach%2C+David+M%3BHarris%2C+Shawn+F&rft.aulast=Peddada&rft.aufirst=Shyamal&rft.date=2009-12-22&rft.volume=10&rft.issue=&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-10-438 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; Tumor cell lines; software; Statistics; Data processing; Algorithms; Breast cancer; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-10-438 ER - TY - JOUR T1 - Requirement of arsenic biomethylation for oxidative DNA damage. AN - 734193111; 19933942 AB - Inorganic arsenic is an environmental carcinogen that may act through multiple mechanisms including formation of methylated derivatives in vivo. Sodium arsenite (up to 5.0 microM) renders arsenic methylation-competent TRL1215 rat liver epithelial cells tumorigenic in nude mice at 18 weeks of exposure and arsenic methylation-deficient RWPE-1 human prostate epithelial cells tumorigenic at 30 weeks of exposure. We assessed the role of arsenic biomethylation in oxidative DNA damage (ODD) using a recently developed immuno-spin trapping method. Immuno-spin trapping was used to measure ODD after chronic exposure of cultured TRL1215 vs RWPE-1 cells, or of methylation-competent UROtsa/F35 vs methylation-deficient UROtsa human urothelial cells, to sodium arsenite. Secreted matrix metalloproteinase (MMP)-2 and -9 activity, as analyzed by zymography, cellular invasiveness by using a transwell assay, and colony formation by using soft agar assay were compared in cells exposed to arsenite with and without selenite, an arsenic biomethylation inhibitor, to assess the role of ODD in the transition to an in vitro cancer phenotype. Exposure of methylation-competent TRL1215 cells to up to 1.0 microM sodium arsenite was followed by a substantial increase in ODD at 5-18 weeks (eg, at 16 weeks with 1.0 microM arsenite, 1138% of control, 95% confidence interval [CI] = 797% to 1481%), whereas exposure of methylation-deficient RWPE-1 cells to up to 5.0 microM arsenite did not increase ODD for a 30-week period. Inhibition of arsenic biomethylation with sodium selenite abolished arsenic-induced ODD and invasiveness, colony formation, and MMP-2 and -9 hypersecretion in TRL1215 cells. Arsenic induced ODD in methylation-competent UROtsa/F35 cells (eg, at 16 weeks, with 1.0 microM arsenite 225% of control, 95% CI = 188% to 262%) but not in arsenic methylation-deficient UROtsa cells, and ODD levels corresponded to the levels of increased invasiveness, colony formation, and hypersecretion of active MMP-2 and -9 seen after transformation to an in vitro cancer phenotype. Arsenic biomethylation appears to be obligatory for arsenic-induced ODD and appears linked in some cells with the accelerated transition to an in vitro cancer phenotype. JF - Journal of the National Cancer Institute AU - Kojima, Chikara AU - Ramirez, Dario C AU - Tokar, Erik J AU - Himeno, Seiichiro AU - Drobná, Zuzana AU - Stýblo, Miroslav AU - Mason, Ronald P AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/12/16/ PY - 2009 DA - 2009 Dec 16 SP - 1670 EP - 1681 VL - 101 IS - 24 KW - Arsenites KW - 0 KW - Carcinogens KW - Enzyme Inhibitors KW - Matrix Metalloproteinase Inhibitors KW - Sodium Compounds KW - sodium arsenite KW - 48OVY2OC72 KW - Methyltransferases KW - EC 2.1.1.- KW - AS3MT protein, human KW - EC 2.1.1.137 KW - Sodium Selenite KW - HIW548RQ3W KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Arsenic -- adverse effects KW - Animals KW - Liver -- cytology KW - Sodium Selenite -- pharmacology KW - Humans KW - Urinary Bladder -- cytology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Phenotype KW - Rats KW - Spin Trapping KW - Epithelial Cells KW - Cells, Cultured KW - Time Factors KW - Prostate -- cytology KW - Male KW - Methyltransferases -- genetics KW - Polymorphism, Genetic -- drug effects KW - Enzyme Inhibitors -- adverse effects KW - Methyltransferases -- drug effects KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms, Experimental -- genetics KW - DNA Methylation -- drug effects KW - Oxidative Stress -- drug effects KW - Carcinogens -- toxicity KW - Sodium Compounds -- adverse effects KW - Arsenites -- adverse effects KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734193111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Requirement+of+arsenic+biomethylation+for+oxidative+DNA+damage.&rft.au=Kojima%2C+Chikara%3BRamirez%2C+Dario+C%3BTokar%2C+Erik+J%3BHimeno%2C+Seiichiro%3BDrobn%C3%A1%2C+Zuzana%3BSt%C3%BDblo%2C+Miroslav%3BMason%2C+Ronald+P%3BWaalkes%2C+Michael+P&rft.aulast=Kojima&rft.aufirst=Chikara&rft.date=2009-12-16&rft.volume=101&rft.issue=24&rft.spage=1670&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjp414 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-29 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2000 Mar 1;163(2):203-7 [10698679] Toxicol Appl Pharmacol. 2006 Nov 15;217(1):7-14 [16930658] Br J Pharmacol. 2006 Dec;149(7):888-97 [17043674] Exp Biol Med (Maywood). 2007 Jan;232(1):3-13 [17202581] Nat Protoc. 2007;2(3):504-11 [17406614] Nat Protoc. 2007;2(3):512-22 [17406615] Hum Exp Toxicol. 2009 Jan;28(1):49-61 [19411561] Mutat Res. 2009 Jul 10;667(1-2):4-14 [18682255] Chem Res Toxicol. 2009 Oct;22(10):1713-20 [19691357] Toxicol Sci. 2000 Apr;54(2):500-8 [10774833] Anticancer Res. 2000 May-Jun;20(3B):2009-13 [10928143] Arch Toxicol. 2000 Aug;74(6):289-99 [11005674] Chem Res Toxicol. 2001 Apr;14(4):355-61 [11304123] Mol Pharmacol. 2001 Aug;60(2):302-9 [11455017] Toxicol Appl Pharmacol. 2001 Oct 15;176(2):127-44 [11601889] Environ Health Perspect. 2002 Apr;110(4):331-6 [11940449] Chem Res Toxicol. 2002 May;15(5):629-37 [12018983] Chem Res Toxicol. 2002 Dec;15(12):1627-34 [12482246] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Chem Res Toxicol. 2003 Mar;16(3):261-5 [12641425] Clin Cancer Res. 2003 Jul;9(7):2576-82 [12855633] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Arch Biochem Biophys. 2004 Mar 1;423(1):57-65 [14989265] Chem Res Toxicol. 2004 Mar;17(3):404-9 [15025511] Toxicol Sci. 2004 May;79(1):56-63 [14976345] Br J Pharmacol. 2004 May;142(2):231-55 [15155533] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):291-6 [15276408] Free Radic Biol Med. 2004 Sep 1;37(5):574-81 [15288115] Toxicol Appl Pharmacol. 2004 Nov 1;200(3):177-85 [15504454] Science. 1977 Jul 29;197(4302):461-3 [560061] Mutat Res. 1981 Jan;88(1):73-80 [7207493] Urol Res. 1995;23(6):377-80 [8788275] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Chem Res Toxicol. 1998 Apr;11(4):273-83 [9548797] Arch Toxicol. 2005 Apr;79(4):183-91 [15526190] Int J Cancer. 2005 Aug 10;116(1):20-6 [15756686] Braz J Med Biol Res. 2005 Jul;38(7):995-1014 [16007271] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Toxicol Appl Pharmacol. 2005 Sep 1;207(2):147-59 [16102566] Biol Pharm Bull. 2005 Oct;28(10):1827-32 [16204930] Biol Trace Elem Res. 2005 Winter;108(1-3):115-26 [16327065] Nat Methods. 2006 Feb;3(2):123-7 [16432522] Br J Cancer. 2006 Feb 27;94(4):569-77 [16465195] Toxicol Sci. 2006 May;91(1):70-81 [16436460] Med Hypotheses. 2006;67(2):318-22 [16574336] Toxicol Appl Pharmacol. 2006 Oct 1;216(1):69-79 [16806342] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15 [16876216] Comment In: J Natl Cancer Inst. 2009 Dec 16;101(24):1660-1 [19933940] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djp414 ER - TY - JOUR T1 - Mortality From Lymphohematopoietic Malignancies and Brain Cancer Among Embalmers Exposed to Formaldehyde AN - 21257899; 11832555 AB - Background Excess mortality from lymphohematopoietic malignancies, in particular myeloid leukemia, and brain cancer has been found in surveys of anatomists, pathologists, and funeral industry workers, all of whom may have worked with formaldehyde. We investigated the relation of mortality to work practices and formaldehyde exposure levels among these professionals to address cancer risk in the funeral industry.Methods Professionals employed in the funeral industry who died between January 1, 1960, and January 1, 1986, from lymphohematopoietic malignancies (n = 168) or brain tumors (n = 48) (ie, case subjects) were compared with deceased matched control subjects (n = 265) with regard to lifetime work practices and exposures in the funeral industry, which were obtained by interviews with next of kin and coworkers, and to estimated levels of formaldehyde exposure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by use of logistic regression. All statistical tests were two-sided.Results Mortality from myeloid leukemia increased statistically significantly with increasing number of years of embalming (P for trend = .020) and with increasing peak formaldehyde exposure (P for trend = .036). Compared with subjects who performed fewer than 500 lifetime embalmings, mortality from myeloid leukemia was elevated among those who performed embalmings for more than 34 years (OR = 3.9, 95% CI = 1.2 to 12.5, P = .024), who performed more than 3068 embalmings (OR = 3.0, 95% CI = 1.0 to 9.2, P = .057), and those whose estimated cumulative formaldehyde exposure exceeded 9253 parts per million-hours (OR = 3.1; 95% CI = 1.0 to 9.6, P = .047). These exposures were not related to other lymphohematopoietic malignancies or to brain cancer.Conclusion Duration of embalming practice and related formaldehyde exposures in the funeral industry were associated with statistically significantly increased risk for mortality from myeloid leukemia. JF - Journal of the National Cancer Institute AU - Hauptmann, Michael AU - Stewart, Patricia A AU - Lubin, Jay H AU - Beane Freeman, Laura E AU - Hornung, Richard W AU - Herrick, Robert F AU - Hoover, Robert N AU - Fraumeni, Joseph F AU - Blair, Aaron AU - Hayes, Richard B Y1 - 2009/12/16/ PY - 2009 DA - 2009 Dec 16 SP - 1696 EP - 1708 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 24 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Immunology Abstracts; CSA Neurosciences Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Myeloid leukemia KW - Brain KW - Statistical analysis KW - Formaldehyde KW - Cancer KW - Brain tumors KW - Leukemia KW - Workers KW - Malignancy KW - brain tumors KW - Occupational exposure KW - R2 23080:Industrial and labor KW - F 06915:Cancer Immunology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21257899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Mortality+From+Lymphohematopoietic+Malignancies+and+Brain+Cancer+Among+Embalmers+Exposed+to+Formaldehyde&rft.au=Hauptmann%2C+Michael%3BStewart%2C+Patricia+A%3BLubin%2C+Jay+H%3BBeane+Freeman%2C+Laura+E%3BHornung%2C+Richard+W%3BHerrick%2C+Robert+F%3BHoover%2C+Robert+N%3BFraumeni%2C+Joseph+F%3BBlair%2C+Aaron%3BHayes%2C+Richard+B&rft.aulast=Hauptmann&rft.aufirst=Michael&rft.date=2009-12-16&rft.volume=101&rft.issue=24&rft.spage=1696&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp416 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Brain tumors; Workers; Mortality; Malignancy; Myeloid leukemia; Statistical analysis; Formaldehyde; Cancer; Leukemia; Brain; brain tumors; Occupational exposure DO - http://dx.doi.org/10.1093/jnci/djp416 ER - TY - JOUR T1 - Stabilization of the Nitric Oxide (NO) Prodrugs and Anticancer Leads, PABA/NO and Double JS-K, through Incorporation into PEG-Protected Nanoparticles AN - 754551557; 13305448 AB - We report the stabilization of the nitric oxide (NO) prodrugs and anticancer lead compounds, PABA/NO (O2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate) and 'Double JS-K' 1,5-bis-{1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diol - 2-ato}-2,4-dinitrobenzene, through their incorporation into polymer-protected nanoparticles. The prodrugs were formulated in block copolymer-stabilized nanoparticles with sizes from 220 to 450 nm by a novel rapid precipitation process. The block copolymers, with polyethylene glycol (PEG) soluble blocks, provide a steric barrier against NO prodrug activation by glutathione. Too rapid activation and NO release has been a major barrier to effective administration of this class of compounds. The nanoparticle stabilized PABA/NO are protected from attack by glutathione as evidenced by a significant increase in time taken for 50% decomposition from 15 min (unformulated) to 5 h (formulated); in the case of Double JS-K, the 50% decomposition time was extended from 4.5 min (unformulated) to 40 min (formulated). The more hydrophobic PABA/NO produced more stable nanoparticles and correspondingly more extended release times in comparison with Double JS-K. The hydrophobic blocks of the polymer were either polystyrene or polylactide. Both blocks produced nanoparticles of approximately the same size and release kinetics. This combination of PEG-protected nanoparticles with sizes appropriate for cancer targeting by enhanced permeation and retention (EPR) and delayed release of NO may afford enhanced therapeutic benefit. JF - Molecular Pharmaceutics AU - Kumar, Varun AU - Hong, Sam Y AU - MacIag, Anna E AU - Saavedra, Joseph E AU - Adamson, Douglas H AU - Prud'homme, Robert K AU - Keefer, Larry K AU - Chakrapani, Harinath AD - Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, Chemistry Section, Laboratory of Comparative Carcinogenesis, and Basic Science Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, Department of Chemistry and Institute for Material Science, University of Connecticut, Storrs, Connecticut 06269, and Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 291 EP - 298 PB - American Chemical Society VL - 7 IS - 1 SN - 1543-8384, 1543-8384 KW - Biotechnology and Bioengineering Abstracts KW - Glutathione KW - Hydrophobicity KW - Precipitation KW - Decomposition KW - Lead KW - Cancer KW - prodrugs KW - Kinetics KW - polystyrene KW - Copolymers KW - polylactide KW - Nitric oxide KW - Polyethylene glycol KW - nanoparticles KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754551557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Stabilization+of+the+Nitric+Oxide+%28NO%29+Prodrugs+and+Anticancer+Leads%2C+PABA%2FNO+and+Double+JS-K%2C+through+Incorporation+into+PEG-Protected+Nanoparticles&rft.au=Kumar%2C+Varun%3BHong%2C+Sam+Y%3BMacIag%2C+Anna+E%3BSaavedra%2C+Joseph+E%3BAdamson%2C+Douglas+H%3BPrud%27homme%2C+Robert+K%3BKeefer%2C+Larry+K%3BChakrapani%2C+Harinath&rft.aulast=Kumar&rft.aufirst=Varun&rft.date=2009-12-15&rft.volume=7&rft.issue=1&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp900245h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Glutathione; Hydrophobicity; Precipitation; Decomposition; Cancer; Lead; prodrugs; Kinetics; Copolymers; polystyrene; polylactide; Nitric oxide; nanoparticles; Polyethylene glycol DO - http://dx.doi.org/10.1021/mp900245h ER - TY - JOUR T1 - Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations AN - 745642232; 13163312 AB - CDKN2A is a major susceptibility gene for cutaneous malignant melanoma (CMM), but the variable penetrance and clinical manifestations among mutation carriers suggest the existence of modifier factors. The goal of this study was to identify modifier genes for CMM in CMM-prone families with or without CDKN2A mutations. We genotyped 537 individuals (107 CMM) from 28 families (19 CDKN2A+, 9 CDKN2A-) for 1,536 SNPs in 152 genes involved in DNA repair, apoptosis and immune response pathways. We used conditional logistic regression to account for family ascertainment and differences in disease prevalence among families. Pathway- and gene-based permutation analyses were used to assess the risk of CMM associated with genes in the 5 pathways (DNA repair, apoptosis, TNF/NFB, TH1:TH2 and other immune regulation). Our analyses identified some candidate genes such as FAS, BCL7A, CASP14, TRAF6, WRN, IL9, IL10RB, TNFSF8, TNFRSF9 and JAK3 that were associated with CMM risk (p < 0.01, gene-based test). After correction for multiple comparisons, IL9 remained significant (Bonferroni p < 0.05). The effects of some genes were stronger in CDKN2A-positive families (BCL7A and IL9), while some were stronger in CDKN2A-negative families (BCL2L1). Our findings support the hypothesis that common genetic polymorphisms in DNA repair, apoptosis and immune response pathways may modify the risk of CMM in CMM-prone families with or without CDKN2A mutations. Published 2009 UICC. JF - International Journal of Cancer AU - Yang, Xiaohong Rose AU - Pfeiffer, Ruth M AU - Wheeler, William AU - Yeager, Meredith AU - Chanock, Stephen AU - Tucker, Margaret A AU - Goldstein, Alisa M AD - Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, MD, royang@mail.nih.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 2912 EP - 2917 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 12 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Toxicology Abstracts; Risk Abstracts; Immunology Abstracts KW - Immunoregulation KW - Apoptosis KW - Tumor necrosis factor KW - Gene polymorphism KW - Interleukin 1 KW - TRAF6 protein KW - melanoma KW - DNA repair KW - Cancer KW - Melanoma KW - Interleukin 9 KW - Single-nucleotide polymorphism KW - Fas antigen KW - Janus kinase 3 KW - DNA KW - CD95 antigen KW - Immune response KW - Mutation KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Identification+of+modifier+genes+for+cutaneous+malignant+melanoma+in+melanoma-prone+families+with+and+without+CDKN2A+mutations&rft.au=Yang%2C+Xiaohong+Rose%3BPfeiffer%2C+Ruth+M%3BWheeler%2C+William%3BYeager%2C+Meredith%3BChanock%2C+Stephen%3BTucker%2C+Margaret+A%3BGoldstein%2C+Alisa+M&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2009-12-15&rft.volume=125&rft.issue=12&rft.spage=2912&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24622 L2 - http://www3.interscience.wiley.com/journal/122420370/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Apoptosis; Gene polymorphism; Tumor necrosis factor; Interleukin 1; TRAF6 protein; DNA repair; Interleukin 9; Melanoma; Fas antigen; Single-nucleotide polymorphism; Janus kinase 3; CD95 antigen; Immune response; Mutation; DNA; melanoma; Cancer DO - http://dx.doi.org/10.1002/ijc.24622 ER - TY - JOUR T1 - Psychosocial interventions in breast cancer AN - 745631304; 12746152 AB - A broad literature supports the importance of lifestyle, stress, and other psychosocial variables as independent risk factors for cancer and other diseases. To alleviate their effects, progress can be made through well-designed clinical trials. JF - Cancer AU - Kaufmann, Peter G AD - National Heart, Lung and Blood Institute, Clinical Applications and Prevention Branch, Bethesda, Maryland, kaufmannp@nhlbi.nih.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 5617 EP - 5619 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 115 IS - 24 SN - 0008-543X, 0008-543X KW - Risk Abstracts KW - intervention KW - Breast cancer KW - Stress KW - clinical trials KW - Cancer KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745631304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Psychosocial+interventions+in+breast+cancer&rft.au=Kaufmann%2C+Peter+G&rft.aulast=Kaufmann&rft.aufirst=Peter&rft.date=2009-12-15&rft.volume=115&rft.issue=24&rft.spage=5617&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24659 L2 - http://www3.interscience.wiley.com/journal/122648733/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - intervention; Stress; Breast cancer; clinical trials; Cancer DO - http://dx.doi.org/10.1002/cncr.24659 ER - TY - JOUR T1 - A novel method for mining highly imbalanced high-throughput screening data in PubChem AN - 21283274; 11832263 AB - Motivation: The comprehensive information of small molecules and their biological activities in PubChem brings great opportunities for academic researchers. However, mining high-throughput screening (HTS) assay data remains a great challenge given the very large data volume and the highly imbalanced nature with only small number of active compounds compared to inactive compounds. Therefore, there is currently a need for better strategies to work with HTS assay data. Moreover, as luciferase-based HTS technology is frequently exploited in the assays deposited in PubChem, constructing a computational model to distinguish and filter out potential interference compounds for these assays is another motivation.Results: We used the granular support vector machines (SVMs) repetitive under sampling method (GSVM-RU) to construct an SVM from luciferase inhibition bioassay data that the imbalance ratio of active-inactive is high (1-377). The best model recognized the active and inactive compounds at the accuracies of 86.60% and 88.89 with a total accuracy of 87.74%, by cross-validation test and blind test. These results demonstrate the robustness of the model in handling the intrinsic imbalance problem in HTS data and it can be used as a virtual screening tool to identify potential interference compounds in luciferase-based HTS experiments. Additionally, this method has also proved computationally efficient by greatly reducing the computational cost and can be easily adopted in the analysis of HTS data for other biological systems.Availability: Data are publicly available in PubChem with AIDs of 773, 1006 and 1379. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Li, Qingliang AU - Wang, Yanli AU - Bryant, Stephen H Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 3310 EP - 3316 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 24 SN - 1367-4803, 1367-4803 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Data processing KW - Mathematical models KW - high-throughput screening KW - Bioinformatics KW - Sampling KW - Computer applications KW - Models KW - V 22360:AIDS and HIV KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21283274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+novel+method+for+mining+highly+imbalanced+high-throughput+screening+data+in+PubChem&rft.au=Li%2C+Qingliang%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Li&rft.aufirst=Qingliang&rft.date=2009-12-15&rft.volume=25&rft.issue=24&rft.spage=3310&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp589 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Filters; Mathematical models; Data processing; high-throughput screening; Sampling; Bioinformatics; Computer applications; Models DO - http://dx.doi.org/10.1093/bioinformatics/btp589 ER - TY - JOUR T1 - Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication AN - 21049313; 11302741 AB - We describe the development of a new type of scaffold to target RNA structures. Multivalent binding oligomers (MBOs) are molecules in which multiple sidechains extend from a polyamine backbone such that favorable RNA binding occurs. We have used this strategy to develop MBO-based inhibitors to prevent the association of a protein-RNA complex, Tat-TAR, that is essential for HIV replication. In vitro binding assays combined with model cell-based assays demonstrate that the optimal MBOs inhibit Tat-TAR binding at low micromolar concentrations. Antiviral studies are also consistent with the in vitro and cell-based assays. MBOs provide a framework for the development of future RNA-targeting molecules. JF - Bioorganic and Medicinal Chemistry Letters AU - Wang, Deyun AU - Iera, Jaclyn AU - Baker, Heather AU - Hogan, Priscilla AU - Ptak, Roger AU - Yang, Lu AU - Hartman, Tracy AU - Buckheit, Robert W AU - Desjardins, Alexandre AU - Yang, Ao AU - Legault, Pascale AU - Yedavalli, Venkat AU - Jeang, Kuan-Teh AU - Appella, Daniel H AD - Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, MD 20892, United States, appellad@niddk.nih.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 6893 EP - 6897 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 24 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - RNA KW - Human immunodeficiency virus KW - Replication KW - polyamines KW - scaffolds KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21049313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Multivalent+binding+oligomers+inhibit+HIV+Tat-TAR+interaction+critical+for+viral+replication&rft.au=Wang%2C+Deyun%3BIera%2C+Jaclyn%3BBaker%2C+Heather%3BHogan%2C+Priscilla%3BPtak%2C+Roger%3BYang%2C+Lu%3BHartman%2C+Tracy%3BBuckheit%2C+Robert+W%3BDesjardins%2C+Alexandre%3BYang%2C+Ao%3BLegault%2C+Pascale%3BYedavalli%2C+Venkat%3BJeang%2C+Kuan-Teh%3BAppella%2C+Daniel+H&rft.aulast=Wang&rft.aufirst=Deyun&rft.date=2009-12-15&rft.volume=19&rft.issue=24&rft.spage=6893&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.10.078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - RNA; polyamines; Replication; scaffolds; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.bmcl.2009.10.078 ER - TY - JOUR T1 - Projected cancer risks from computed tomographic scans performed in the United States in 2007. AN - 734192349; 20008689 AB - The use of computed tomographic (CT) scans in the United States (US) has increased more than 3-fold since 1993 to approximately 70 million scans annually. Despite the great medical benefits, there is concern about the potential radiation-related cancer risk. We conducted detailed estimates of the future cancer risks from current CT scan use in the US according to age, sex, and scan type. Risk models based on the National Research Council's "Biological Effects of Ionizing Radiation" report and organ-specific radiation doses derived from a national survey were used to estimate age-specific cancer risks for each scan type. These models were combined with age- and sex-specific scan frequencies for the US in 2007 obtained from survey and insurance claims data. We estimated the mean number of radiation-related incident cancers with 95% uncertainty limits (UL) using Monte Carlo simulations. Overall, we estimated that approximately 29 000 (95% UL, 15 000-45 000) future cancers could be related to CT scans performed in the US in 2007. The largest contributions were from scans of the abdomen and pelvis (n = 14 000) (95% UL, 6900-25 000), chest (n = 4100) (95% UL, 1900-8100), and head (n = 4000) (95% UL, 1100-8700), as well as from chest CT angiography (n = 2700) (95% UL, 1300-5000). One-third of the projected cancers were due to scans performed at the ages of 35 to 54 years compared with 15% due to scans performed at ages younger than 18 years, and 66% were in females. These detailed estimates highlight several areas of CT scan use that make large contributions to the total cancer risk, including several scan types and age groups with a high frequency of use or scans involving relatively high doses, in which risk-reduction efforts may be warranted. JF - Archives of internal medicine AU - Berrington de González, Amy AU - Mahesh, Mahadevappa AU - Kim, Kwang-Pyo AU - Bhargavan, Mythreyi AU - Lewis, Rebecca AU - Mettler, Fred AU - Land, Charles AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. berringtona@mail.nih.gov Y1 - 2009/12/14/ PY - 2009 DA - 2009 Dec 14 SP - 2071 EP - 2077 VL - 169 IS - 22 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Radiation Dosage KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Neoplasms, Radiation-Induced -- etiology KW - Tomography, X-Ray Computed -- adverse effects KW - Neoplasms, Radiation-Induced -- epidemiology KW - Tomography, X-Ray Computed -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734192349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Projected+cancer+risks+from+computed+tomographic+scans+performed+in+the+United+States+in+2007.&rft.au=Berrington+de+Gonz%C3%A1lez%2C+Amy%3BMahesh%2C+Mahadevappa%3BKim%2C+Kwang-Pyo%3BBhargavan%2C+Mythreyi%3BLewis%2C+Rebecca%3BMettler%2C+Fred%3BLand%2C+Charles&rft.aulast=Berrington+de+Gonz%C3%A1lez&rft.aufirst=Amy&rft.date=2009-12-14&rft.volume=169&rft.issue=22&rft.spage=2071&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=1538-3679&rft_id=info:doi/10.1001%2Farchinternmed.2009.440 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-11 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2009 Dec 14;169(22):2049-50 [20008685] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archinternmed.2009.440 ER - TY - JOUR T1 - Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase. AN - 733694970; 20003456 AB - beta-carotene 15,15'-monooxygenase (BCMO1) catalyzes the crucial first step in vitamin A biosynthesis in animals. We wished to explore the possibility that a carbocation intermediate is formed during the cleavage reaction of BCMO1, as is seen for many isoprenoid biosynthesis enzymes, and to determine which residues in the substrate binding cleft are necessary for catalytic and substrate binding activity. To test this hypothesis, we replaced substrate cleft aromatic and acidic residues by site-directed mutagenesis. Enzymatic activity was measured in vitro using His-tag purified proteins and in vivo in a beta-carotene-accumulating E. coli system. Our assays show that mutation of either Y235 or Y326 to leucine (no cation-pi stabilization) significantly impairs the catalytic activity of the enzyme. Moreover, mutation of Y326 to glutamine (predicted to destabilize a putative carbocation) almost eliminates activity (9.3% of wt activity). However, replacement of these same tyrosines with phenylalanine or tryptophan does not significantly impair activity, indicating that aromaticity at these residues is crucial. Mutations of two other aromatic residues in the binding cleft of BCMO1, F51 and W454, to either another aromatic residue or to leucine do not influence the catalytic activity of the enzyme. Our ab initio model of BCMO1 with beta-carotene mounted supports a mechanism involving cation-pi stabilization by Y235 and Y326. Our data are consistent with the formation of a substrate carbocation intermediate and cation-pi stabilization of this intermediate by two aromatic residues in the substrate-binding cleft of BCMO1. JF - BMC biochemistry AU - Poliakov, Eugenia AU - Gentleman, Susan AU - Chander, Preethi AU - Cunningham, Francis X AU - Grigorenko, Bella L AU - Nemuhin, Alexander V AU - Redmond, T Michael AD - National Eye Institute, NIH, Bethesda, MD 20892-0608, USA. poliakove@nei.nih.gov Y1 - 2009/12/14/ PY - 2009 DA - 2009 Dec 14 SP - 31 VL - 10 KW - Cations KW - 0 KW - beta Carotene KW - 01YAE03M7J KW - Tyrosine KW - 42HK56048U KW - Diphenylamine KW - 9N3CBB0BIQ KW - beta-Carotene 15,15'-Monooxygenase KW - EC 1.14.99.36 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Diphenylamine -- pharmacology KW - Animals KW - Diphenylamine -- chemistry KW - Sequence Alignment KW - Molecular Sequence Data KW - Catalytic Domain KW - Mice KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - beta Carotene -- metabolism KW - Amino Acid Substitution KW - Tyrosine -- chemistry KW - beta-Carotene 15,15'-Monooxygenase -- metabolism KW - beta-Carotene 15,15'-Monooxygenase -- genetics KW - beta-Carotene 15,15'-Monooxygenase -- chemistry KW - Tyrosine -- metabolism KW - Cations -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733694970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+biochemistry&rft.atitle=Biochemical+evidence+for+the+tyrosine+involvement+in+cationic+intermediate+stabilization+in+mouse+beta-carotene+15%2C+15%27-monooxygenase.&rft.au=Poliakov%2C+Eugenia%3BGentleman%2C+Susan%3BChander%2C+Preethi%3BCunningham%2C+Francis+X%3BGrigorenko%2C+Bella+L%3BNemuhin%2C+Alexander+V%3BRedmond%2C+T+Michael&rft.aulast=Poliakov&rft.aufirst=Eugenia&rft.date=2009-12-14&rft.volume=10&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=BMC+biochemistry&rft.issn=1471-2091&rft_id=info:doi/10.1186%2F1471-2091-10-31 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-11 N1 - Date created - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2091-10-31 ER - TY - CPAPER T1 - Pursuing vector-based transmission-blocking vaccines T2 - 57th Annual Meeting of the Entomological Society of America AN - 42288144; 5629070 JF - 57th Annual Meeting of the Entomological Society of America AU - Jochim, Ryan Y1 - 2009/12/13/ PY - 2009 DA - 2009 Dec 13 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42288144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Pursuing+vector-based+transmission-blocking+vaccines&rft.au=Jochim%2C+Ryan&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2009-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2009/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of the host response to sand fly bite: implications for sand fly transmitted Leishmania infection T2 - 57th Annual Meeting of the Entomological Society of America AN - 42286978; 5629069 JF - 57th Annual Meeting of the Entomological Society of America AU - Peters, Nathan Y1 - 2009/12/13/ PY - 2009 DA - 2009 Dec 13 KW - Sand KW - Infection KW - Bites KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42286978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Dynamics+of+the+host+response+to+sand+fly+bite%3A+implications+for+sand+fly+transmitted+Leishmania+infection&rft.au=Peters%2C+Nathan&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2009-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2009/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells T2 - 2009 Reprogramming Cell Fate Conference AN - 42231644; 5594487 JF - 2009 Reprogramming Cell Fate Conference AU - Gattinoni, Luca AU - Zhong, Xiao-Song AU - Palmer, Douglas AU - Ji, Yun AU - Hinrichs, Christian AU - Yu, Zhiya AU - Wrzesinski, Claudia AU - Boni, Andrea AU - Cassard, Lydie AU - Church, Lindsay AU - Paulos, Chrystal AU - Muranski, Pawel AU - Restifo, Nicholas Y1 - 2009/12/11/ PY - 2009 DA - 2009 Dec 11 KW - Arrests KW - Stem cells KW - Cell differentiation KW - Signal transduction KW - Wnt protein KW - Memory cells KW - CD8 antigen KW - Differentiation KW - Lymphocytes T KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42231644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Reprogramming+Cell+Fate+Conference&rft.atitle=Wnt+signaling+arrests+effector+T+cell+differentiation+and+generates+CD8%2B+memory+stem+cells&rft.au=Gattinoni%2C+Luca%3BZhong%2C+Xiao-Song%3BPalmer%2C+Douglas%3BJi%2C+Yun%3BHinrichs%2C+Christian%3BYu%2C+Zhiya%3BWrzesinski%2C+Claudia%3BBoni%2C+Andrea%3BCassard%2C+Lydie%3BChurch%2C+Lindsay%3BPaulos%2C+Chrystal%3BMuranski%2C+Pawel%3BRestifo%2C+Nicholas&rft.aulast=Gattinoni&rft.aufirst=Luca&rft.date=2009-12-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Reprogramming+Cell+Fate+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.semm.it/events/material/reprogramming09/AbstractBookReprogr amming09web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. AN - 733694123; 20007560 AB - Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection and graft-versus-host disease (GVHD) are additional barriers to its success. We performed nonmyeloablative stem-cell transplantation in adults with sickle cell disease. Ten adults (age range, 16 to 45 years) with severe sickle cell disease underwent nonmyeloablative transplantation with CD34+ peripheral-blood stem cells, mobilized by granulocyte colony-stimulating factor (G-CSF), which were obtained from HLA-matched siblings. The patients received 300 cGy of total-body irradiation plus alemtuzumab before transplantation, and sirolimus was administered afterward. All 10 patients were alive at a median follow-up of 30 months after transplantation (range, 15 to 54). Nine patients had long-term, stable donor lymphohematopoietic engraftment at levels that sufficed to reverse the sickle cell disease phenotype. Mean (+/-SE) donor-recipient chimerism for T cells (CD3+) and myeloid cells (CD14+15+) was 53.3+/-8.6% and 83.3+/-10.3%, respectively, in the nine patients whose grafts were successful. Hemoglobin values before transplantation and at the last follow-up assessment were 9.0+/-0.3 and 12.6+/-0.5 g per deciliter, respectively. Serious adverse events included the narcotic-withdrawal syndrome and sirolimus-associated pneumonitis and arthralgia. Neither acute nor chronic GVHD developed in any patient. A protocol for nonmyeloablative allogeneic hematopoietic stem-cell transplantation that includes total-body irradiation and treatment with alemtuzumab and sirolimus can achieve stable, mixed donor-recipient chimerism and reverse the sickle cell phenotype. (ClinicalTrials.gov number, NCT00061568.) 2009 Massachusetts Medical Society JF - The New England journal of medicine AU - Hsieh, Matthew M AU - Kang, Elizabeth M AU - Fitzhugh, Courtney D AU - Link, M Beth AU - Bolan, Charles D AU - Kurlander, Roger AU - Childs, Richard W AU - Rodgers, Griffin P AU - Powell, Jonathan D AU - Tisdale, John F AD - Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. Y1 - 2009/12/10/ PY - 2009 DA - 2009 Dec 10 SP - 2309 EP - 2317 VL - 361 IS - 24 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antigens, CD34 KW - Antineoplastic Agents KW - Hemoglobins KW - Narcotics KW - alemtuzumab KW - 3A189DH42V KW - Sirolimus KW - W36ZG6FT64 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Substance Withdrawal Syndrome KW - Humans KW - Transplantation Chimera KW - Narcotics -- adverse effects KW - Transplantation, Homologous KW - Leukocyte Count KW - Hemoglobins -- analysis KW - Histocompatibility Testing KW - Neutrophils KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Clinical Protocols KW - Female KW - Male KW - Sirolimus -- adverse effects KW - Whole-Body Irradiation KW - Transplantation Conditioning -- methods KW - Anemia, Sickle Cell -- therapy KW - Antibodies, Neoplasm -- therapeutic use KW - Sirolimus -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Hematopoietic Stem Cell Transplantation -- methods KW - Hematopoietic Stem Cell Transplantation -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733694123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Structure+and+Energetics+of+Encapsidated+DNA+in+Bacteriophage+HK97+Studied+by+Scanning+Calorimetry+and+Cryo-electron+Microscopy&rft.au=Duda%2C+R+L%3BRoss%2C+P+D%3BCheng%2C+N%3BFirek%2C+BA%3BHendrix%2C+R+W%3BConway%2C+J+F%3BSteven%2C+A+C&rft.aulast=Duda&rft.aufirst=R&rft.date=2009-08-14&rft.volume=391&rft.issue=2&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2009.06.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00061568; ClinicalTrials.gov N1 - SuppNotes - Cited By: Br J Haematol. 2005 Mar;128(5):668-75 [15725089] Drug Saf. 2005;28(2):153-81 [15691225] Transplantation. 2005 Dec 15;80(11):1541-5 [16371922] Br J Haematol. 2006 May;133(3):305-14 [16643433] Blood. 2006 Oct 15;108(8):2867-73 [16788100] Curr Opin Investig Drugs. 2006 Nov;7(11):1002-7 [17117589] J Immunol. 2006 Dec 15;177(12):8338-47 [17142730] Bone Marrow Transplant. 2007 May;39(9):537-45 [17351648] Blood. 2007 Apr 1;109(7):3108-14 [17138818] Am J Respir Crit Care Med. 2007 Jun 15;175(12):1272-9 [17379852] Blood. 2007 Oct 1;110(7):2749-56 [17606762] Biol Blood Marrow Transplant. 2008 Feb;14(2):256-7 [18215786] Bone Marrow Transplant. 2008 Jul;42(1):51-6 [18372907] Medicine (Baltimore). 2005 Nov;84(6):363-76 [16267411] Blood. 2004 Dec 1;104(12):3501-6 [15292060] Science. 1949 Nov 25;110(2865):543-8 [15395398] N Engl J Med. 2000 Sep 14;343(11):750-8 [10984562] Blood. 2000 Oct 1;96(7):2419-25 [11001893] Lancet. 2001 Mar 3;357(9257):680-3 [11247552] Blood. 2001 Sep 15;98(6):1687-94 [11535498] Bone Marrow Transplant. 2001 Sep;28(5):511-8 [11593326] Biol Blood Marrow Transplant. 2001;7(12):665-73 [11787529] Blood. 2002 Feb 1;99(3):850-5 [11806986] Cytotherapy. 2001;3(4):261-7 [12171714] JAMA. 2003 Apr 2;289(13):1645-51 [12672732] Blood. 2003 Jul 1;102(1):404-6 [12623851] Biol Blood Marrow Transplant. 2003 Aug;9(8):519-28 [12931121] N Engl J Med. 2004 Feb 26;350(9):886-95 [14985486] Blood. 2004 Jun 1;103(11):4023-7 [14764527] Ann Intern Med. 1991 Oct 15;115(8):614-20 [1892333] Blood. 1993 Aug 1;82(3):807-12 [7687895] N Engl J Med. 1996 Aug 8;335(6):369-76 [8663884] Bone Marrow Transplant. 1998 Jul;22(1):1-6 [9678788] J Immunol. 1999 Mar 1;162(5):2775-84 [10072524] Nature. 1957 Aug 17;180(4581):326-8 [13464827] Comment In: N Engl J Med. 2010 Mar 11;362(10):955-6; author reply 956 [20225347] N Engl J Med. 2009 Dec 10;361(24):2380-1 [20007564] N Engl J Med. 2010 Mar 11;362(10):955; author reply 956 [20220194] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMoa0904971 ER - TY - JOUR T1 - Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal AN - 21157039; 11265479 AB - Fetal exposure of mice to arsenic and subsequent postnatal diethylstilbestrol (DES) facilitates production of urogenital system and liver tumors in the offspring when they reach adulthood. The adrenal is a target of endocrine disruption that could influence tumor formation at other sites. Thus, we examined possible fetal arsenic-induced adrenal effects as a potential basis of arsenic enhancement of DES carcinogenesis. Pregnant CD1 mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from day 8 to day 18 of gestation and were allowed to deliver normally. Groups of offspring were subsequently injected s.c. on postpartum days 1-5 with DES (2 kg/pup/day) and killed on postnatal day 12. Total RNA was isolated from the whole adrenal glands, and the expression of various genes was analyzed by real-time RT-PCR. Fetal arsenic exposure greatly enhanced DES-induced, estrogen-linked gene expression, such as estrogen receptor-a and trefoil factors. Expression of genes involved with steroid metabolism and/or methionine metabolism was also increased, including genes encoding for 17b-hydroxysteroid dehydrogenase type 5 (HSD17b5) and androstenedione 15a-hydroxylase (Cyp2a4). The transcripts for homocysteine cycling genes (betaine-homocysteine methyltransferase and thioether S-methyltransferase) and developmental marker genes (a-fetoprotein, insulin-like growth factor 2 and IGF binding protein-1), were also higher with arsenic plus DES than either treatment alone. Thus, exposure of the mouse to arsenic during a critical period of fetal development may potentially alter adrenal genetic programming, leading to endocrine disruption and potentially enhancing tumor formation together with DES at other sites much later in life. Functional studies, such as changes in circulating steroids, would greatly support this hypothesis, and are planned. JF - Chemico-Biological Interactions AU - Liu, Jie AU - Yu, Limei AU - Coppin, Jean-Francois AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, United States, waalkes@niehs.nih.gov Y1 - 2009/12/10/ PY - 2009 DA - 2009 Dec 10 SP - 253 EP - 258 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 182 IS - 2-3 SN - 0009-2797, 0009-2797 KW - Toxicology Abstracts KW - Androstenedione KW - a-fetoprotein KW - Endocrine disruptors KW - Methionine KW - dehydrogenase KW - Postpartum KW - Thioether S-methyltransferase KW - Gestation KW - Polymerase chain reaction KW - Diethylstilbestrol KW - homocysteine KW - Adrenal glands KW - Arsenic KW - Sodium arsenite KW - Tumors KW - Steroid hormones KW - Fetuses KW - Pregnancy KW - Trefoil factor KW - Betaine-homocysteine S-methyltransferase KW - RNA KW - Carcinogenesis KW - Insulin-like growth factors KW - Liver KW - Progeny KW - Neonates KW - Critical period KW - Drinking water KW - Estrogen receptors KW - Metabolism KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21157039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=Fetal+arsenic+exposure+appears+to+facilitate+endocrine+disruption+by+postnatal+diethylstilbestrol+in+neonatal+mouse+adrenal&rft.au=Liu%2C+Jie%3BYu%2C+Limei%3BCoppin%2C+Jean-Francois%3BTokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2009-12-10&rft.volume=182&rft.issue=2-3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Chemico-Biological+Interactions&rft.issn=00092797&rft_id=info:doi/10.1016%2Fj.cbi.2009.07.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Androstenedione; a-fetoprotein; Endocrine disruptors; dehydrogenase; Methionine; Postpartum; Thioether S-methyltransferase; Gestation; Polymerase chain reaction; Diethylstilbestrol; homocysteine; Adrenal glands; Arsenic; Sodium arsenite; Steroid hormones; Tumors; Fetuses; Pregnancy; Betaine-homocysteine S-methyltransferase; Trefoil factor; RNA; Insulin-like growth factors; Carcinogenesis; Liver; Progeny; Neonates; Drinking water; Critical period; Estrogen receptors; Metabolism DO - http://dx.doi.org/10.1016/j.cbi.2009.07.023 ER - TY - CPAPER T1 - Increased Radiation Resistance of Breast Cancer Cells by Endocrine Disrupting Chemical Bisphenol A T2 - 32nd Annual San Antonio Breast Cancer Symposium AN - 42318233; 5644707 JF - 32nd Annual San Antonio Breast Cancer Symposium AU - Kil, Whoon AU - Camphausen, Kevin Y1 - 2009/12/09/ PY - 2009 DA - 2009 Dec 09 KW - Bisphenol A KW - Breast cancer KW - Endocrine disruptors KW - Radiation KW - Endocrinology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.atitle=Increased+Radiation+Resistance+of+Breast+Cancer+Cells+by+Endocrine+Disrupting+Chemical+Bisphenol+A&rft.au=Kil%2C+Whoon%3BCamphausen%2C+Kevin&rft.aulast=Kil&rft.aufirst=Whoon&rft.date=2009-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.abstracts2view.com/sabcs09/sessionindex.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Asian-American Women, Westernization Influences Estrogen Metabolism, But Not Total Endogenous Estrogen Production T2 - 32nd Annual San Antonio Breast Cancer Symposium AN - 42317507; 5644125 JF - 32nd Annual San Antonio Breast Cancer Symposium AU - Ziegler, Regina AU - Fuhrman, Barbara AU - Xu, Xia AU - Gail, Mitchell AU - Keefer, Larry AU - Veenstra, Timothy AU - Hoover, Robert Y1 - 2009/12/09/ PY - 2009 DA - 2009 Dec 09 KW - Estrogens KW - Metabolism KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42317507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.atitle=In+Asian-American+Women%2C+Westernization+Influences+Estrogen+Metabolism%2C+But+Not+Total+Endogenous+Estrogen+Production&rft.au=Ziegler%2C+Regina%3BFuhrman%2C+Barbara%3BXu%2C+Xia%3BGail%2C+Mitchell%3BKeefer%2C+Larry%3BVeenstra%2C+Timothy%3BHoover%2C+Robert&rft.aulast=Ziegler&rft.aufirst=Regina&rft.date=2009-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.abstracts2view.com/sabcs09/sessionindex.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Our Inner Mouse: Genomic Insights from Mouse Mammary Cancer Models To Guide Pre-clinical Testing T2 - 32nd Annual San Antonio Breast Cancer Symposium AN - 42309737; 5643849 JF - 32nd Annual San Antonio Breast Cancer Symposium AU - Green, J Y1 - 2009/12/09/ PY - 2009 DA - 2009 Dec 09 KW - Cancer KW - Animal models KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42309737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.atitle=Our+Inner+Mouse%3A+Genomic+Insights+from+Mouse+Mammary+Cancer+Models+To+Guide+Pre-clinical+Testing&rft.au=Green%2C+J&rft.aulast=Green&rft.aufirst=J&rft.date=2009-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.abstracts2view.com/sabcs09/index.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preventive Effects of Lapatinib, a Combined EGFR 1 and EGFR 2 Inhibitor, on Methylnitrosourea-Induced ER+ and MMTV-Neu/P53 KO ER- Mammary Cancers T2 - 32nd Annual San Antonio Breast Cancer Symposium AN - 42309680; 5643729 JF - 32nd Annual San Antonio Breast Cancer Symposium AU - Lubet, R AU - Bode, A AU - Juliana, M AU - Steele, V Y1 - 2009/12/09/ PY - 2009 DA - 2009 Dec 09 KW - Cancer KW - Epidermal growth factor receptors KW - P53 protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42309680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Overexpression+of+IGF-1+in+muscle+attenuates+disease+in+a+mouse+model+of+spinal+and+bulbar+muscular+atrophy.&rft.au=Palazzolo%2C+Isabella%3BStack%2C+Conor%3BKong%2C+Lingling%3BMusaro%2C+Antonio%3BAdachi%2C+Hiroaki%3BKatsuno%2C+Masahisa%3BSobue%2C+Gen%3BTaylor%2C+J+Paul%3BSumner%2C+Charlotte+J%3BFischbeck%2C+Kenneth+H%3BPennuto%2C+Maria&rft.aulast=Palazzolo&rft.aufirst=Isabella&rft.date=2009-08-13&rft.volume=63&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=1097-4199&rft_id=info:doi/10.1016%2Fj.neuron.2009.07.019 L2 - http://www.abstracts2view.com/sabcs09/sessionindex.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analysis of HER2 Receptors Expression In Vivo by Near-Infrared Optical Imaging T2 - 32nd Annual San Antonio Breast Cancer Symposium AN - 42309594; 5644469 JF - 32nd Annual San Antonio Breast Cancer Symposium AU - Chernomordik, Victor AU - Hassan, Moinuddin AU - Gandjbakhche, Amir AU - Lee, Sang AU - Zielinski, Rafal AU - Capala, Jacek Y1 - 2009/12/09/ PY - 2009 DA - 2009 Dec 09 KW - Quantitative analysis KW - I.R. radiation KW - Imaging techniques KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42309594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.atitle=Quantitative+Analysis+of+HER2+Receptors+Expression+In+Vivo+by+Near-Infrared+Optical+Imaging&rft.au=Chernomordik%2C+Victor%3BHassan%2C+Moinuddin%3BGandjbakhche%2C+Amir%3BLee%2C+Sang%3BZielinski%2C+Rafal%3BCapala%2C+Jacek&rft.aulast=Chernomordik&rft.aufirst=Victor&rft.date=2009-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+San+Antonio+Breast+Cancer+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.abstracts2view.com/sabcs09/sessionindex.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institute of Child Health and Human Development Perspective on Children's Health T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42285646; 5622907 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Louis, Germaine Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Children KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42285646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=National+Institute+of+Child+Health+and+Human+Development+Perspective+on+Children%27s+Health&rft.au=Louis%2C+Germaine&rft.aulast=Louis&rft.aufirst=Germaine&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Future Directions and Meeting Summary Reports from Breakfast Disease Focused Sessions, Clinical and Industry Perspective, Mechanisms and Regulatory Challenges Breakouts T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42284675; 5622957 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Jerrold, Jerrold Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42284675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Future+Directions+and+Meeting+Summary+Reports+from+Breakfast+Disease+Focused+Sessions%2C+Clinical+and+Industry+Perspective%2C+Mechanisms+and+Regulatory+Challenges+Breakouts&rft.au=Jerrold%2C+Jerrold&rft.aulast=Jerrold&rft.aufirst=Jerrold&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Utero Origin of Gynegologic Disorders: Case for the Ovarian Dysgenesis Syndrome T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42283936; 5622940 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Louis, Germaine Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42283936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=In+Utero+Origin+of+Gynegologic+Disorders%3A+Case+for+the+Ovarian+Dysgenesis+Syndrome&rft.au=Louis%2C+Germaine&rft.aulast=Louis&rft.aufirst=Germaine&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - General Discussion: Integration of Developmental Basis of Disease T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42283532; 5622913 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Heindel, Jerrold Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Integration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42283532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=General+Discussion%3A+Integration+of+Developmental+Basis+of+Disease&rft.au=Heindel%2C+Jerrold&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Developmental Basis of Disease: Environmental Impacts T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42281396; 5622910 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Collman, Gwen Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Environmental impact KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42281396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Overview+of+Developmental+Basis+of+Disease%3A+Environmental+Impacts&rft.au=Collman%2C+Gwen&rft.aulast=Collman&rft.aufirst=Gwen&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction of Longitudinal Children's Studies and Worldwide Cohorts T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42281161; 5622920 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Gray, Kimberly Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42281161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Introduction+of+Longitudinal+Children%27s+Studies+and+Worldwide+Cohorts&rft.au=Gray%2C+Kimberly&rft.aulast=Gray&rft.aufirst=Kimberly&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DES Model: Cancer in Animals and Humans T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42280929; 5622918 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Newbold, Retha Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Cancer KW - Animal models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42280929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=The+expanding+p53+universe+of+target+genes&rft.au=Resnick%2C+Michael&rft.aulast=Resnick&rft.aufirst=Michael&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Reproductive Outcomes in Females after Developmental Exposure to Environmental Estrogens: Genistein As an Example T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42278645; 5622936 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Jefferson, Wendy Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Estrogens KW - Genistein KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42278645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Adverse+Reproductive+Outcomes+in+Females+after+Developmental+Exposure+to+Environmental+Estrogens%3A+Genistein+As+an+Example&rft.au=Jefferson%2C+Wendy&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fetal Arsenic Exposure and Adult Cancer T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42278554; 5622914 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Waalkes, Michael Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Cancer KW - Arsenic KW - Fetuses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42278554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Fetal+Arsenic+Exposure+and+Adult+Cancer&rft.au=Waalkes%2C+Michael&rft.aulast=Waalkes&rft.aufirst=Michael&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - United States National Children's Study T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42278268; 5622921 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Park, Christina Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - USA KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42278268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=United+States+National+Children%27s+Study&rft.au=Park%2C+Christina&rft.aulast=Park&rft.aufirst=Christina&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strengthening health governance: and old ''new'' paradigm. What is next? T2 - The Fourth International Jerusalem Conference on Health Policy AN - 42226075; 5596023 JF - The Fourth International Jerusalem Conference on Health Policy AU - Emanuel, Ezekiel AU - Figueras, Josep Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=The+Fourth+International+Jerusalem+Conference+on+Health+Policy&rft.atitle=Strengthening+health+governance%3A+and+old+%27%27new%27%27+paradigm.+What+is+next%3F&rft.au=Emanuel%2C+Ezekiel%3BFigueras%2C+Josep&rft.aulast=Emanuel&rft.aufirst=Ezekiel&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=The+Fourth+International+Jerusalem+Conference+on+Health+Policy&rft.issn=&rft_id=info:doi/ L2 - http://www.israelhpr.org.il/FileServer/621a21ce6481635a04e952f9bafb637 8.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Spatial swarm segregation and reproductive isolation between the molecular forms of Anopheles gambiae AN - 21131550; 11392526 AB - Anopheles gambiae, the major malaria vector in Africa, can be divided into two subgroups based on genetic and ecological criteria. These two subgroups, termed the M and S molecular forms, are believed to be incipient species. Although they display differences in the ecological niches they occupy in the field, they are often sympatric and readily hybridize in the laboratory to produce viable and fertile offspring. Evidence for assortative mating in the field was recently reported, but the underlying mechanisms awaited discovery. We studied swarming behaviour of the molecular forms and investigated the role of swarm segregation in mediating assortative mating. Molecular identification of 1145 males collected from 68 swarms in Doneguebougou, Mali, over 2 years revealed a strict pattern of spatial segregation, resulting in almost exclusively monotypic swarms with respect to molecular form. We found evidence of clustering of swarms composed of individuals of a single molecular form within the village. Tethered M and S females were introduced into natural swarms of the M form to verify the existence of possible mate recognition operating within-swarm. Both M and S females were inseminated regardless of their form under these conditions, suggesting no within-mate recognition. We argue that our results provide evidence that swarm spatial segregation strongly contributes to reproductive isolation between the molecular forms in Mali. However this does not exclude the possibility of additional mate recognition operating across the range distribution of the forms. We discuss the importance of spatial segregation in the context of possible geographic variation in mechanisms of reproductive isolation. JF - Proceedings of the Royal Society of London, Series B: Biological Sciences AU - Diabate, Abdoulaye AU - Dao, Adama AU - Yaro, Alpha S AU - Adamou, Abdoulaye AU - Gonzalez, Rodrigo AU - Manoukis, Nicholas C AU - Traore, Sekou F AU - Gwadz, Robert W AU - Lehmann, Tovi AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20852 Rockville, MD, USA, a_diabate@hotmail.com Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 SP - 4215 EP - 4222 PB - Royal Society of London, 6 Carlton House Terrace London SW1Y 5AG UK VL - 276 IS - 1676 SN - 0962-8452, 0962-8452 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Ecology Abstracts; Animal Behavior Abstracts; Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - molecular forms KW - Anopheles gambiae KW - reproductive isolation KW - swarms KW - Human diseases KW - Mali KW - M form KW - Assortative mating KW - Sympatric populations KW - Ecological distribution KW - Niches KW - Swarming KW - Vectors KW - Sexual isolation KW - Animal physiology KW - Malaria KW - Mate recognition KW - Swarms KW - Reproductive isolation KW - Progeny KW - Reproduction KW - Geographical variations KW - Reproductive behaviour KW - Aquatic insects KW - K 03410:Animal Diseases KW - Y 25040:Behavioral Ecology KW - Q1 08482:Ecosystems and energetics KW - D 04040:Ecosystem and Ecology Studies KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21131550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.atitle=Spatial+swarm+segregation+and+reproductive+isolation+between+the+molecular+forms+of+Anopheles+gambiae&rft.au=Diabate%2C+Abdoulaye%3BDao%2C+Adama%3BYaro%2C+Alpha+S%3BAdamou%2C+Abdoulaye%3BGonzalez%2C+Rodrigo%3BManoukis%2C+Nicholas+C%3BTraore%2C+Sekou+F%3BGwadz%2C+Robert+W%3BLehmann%2C+Tovi&rft.aulast=Diabate&rft.aufirst=Abdoulaye&rft.date=2009-12-07&rft.volume=276&rft.issue=1676&rft.spage=4215&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.issn=09628452&rft_id=info:doi/10.1098%2Frspb.2009.1167 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Human diseases; Niches; Ecological distribution; Sexual isolation; Malaria; Animal physiology; Reproduction; Reproductive behaviour; Aquatic insects; M form; Reproductive isolation; Swarms; Sympatric populations; Assortative mating; Swarming; Vectors; Progeny; Geographical variations; Mate recognition; Anopheles gambiae; Mali DO - http://dx.doi.org/10.1098/rspb.2009.1167 ER - TY - CPAPER T1 - Pathogen Recognition by Toll-like Receptor 3 (TLR3) T2 - 20th IBC's Annual Antibody Engineering Conference and 7th IBC's Annual International Conference on Antibody Therapeutics AN - 42275828; 5619766 JF - 20th IBC's Annual Antibody Engineering Conference and 7th IBC's Annual International Conference on Antibody Therapeutics AU - Segal, David Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Pathogens KW - TLR3 protein KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42275828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IBC%27s+Annual+Antibody+Engineering+Conference+and+7th+IBC%27s+Annual+International+Conference+on+Antibody+Therapeutics&rft.atitle=Pathogen+Recognition+by+Toll-like+Receptor+3+%28TLR3%29&rft.au=Segal%2C+David&rft.aulast=Segal&rft.aufirst=David&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IBC%27s+Annual+Antibody+Engineering+Conference+and+7th+IBC%27s+Annual+International+Conference+on+Antibody+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng/agenda.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Recombinant Immunotoxins Targeted to CD22-Positive Malignancies T2 - 20th IBC's Annual Antibody Engineering Conference and 7th IBC's Annual International Conference on Antibody Therapeutics AN - 42272252; 5619781 JF - 20th IBC's Annual Antibody Engineering Conference and 7th IBC's Annual International Conference on Antibody Therapeutics AU - FitzGerald, David Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Immunotoxins KW - Malignancy KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42272252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+IBC%27s+Annual+Antibody+Engineering+Conference+and+7th+IBC%27s+Annual+International+Conference+on+Antibody+Therapeutics&rft.atitle=Improved+Recombinant+Immunotoxins+Targeted+to+CD22-Positive+Malignancies&rft.au=FitzGerald%2C+David&rft.aulast=FitzGerald&rft.aufirst=David&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+IBC%27s+Annual+Antibody+Engineering+Conference+and+7th+IBC%27s+Annual+International+Conference+on+Antibody+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng/agenda.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ventral Tegmental Area/Hippocampal Interactions: Modulation By BDNF Val66met Genotype T2 - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AN - 42264387; 5613324 JF - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AU - Masdeu, Joseph Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Genotypes KW - Ventral tegmentum KW - Brain-derived neurotrophic factor KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42264387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.atitle=Ventral+Tegmental+Area%2FHippocampal+Interactions%3A+Modulation+By+BDNF+Val66met+Genotype&rft.au=Masdeu%2C+Joseph&rft.aulast=Masdeu&rft.aufirst=Joseph&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/asset.axd?id=a55d7404-334e-43df-a40c-9cda68719743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hibrid Imaging and New Roads to Interventions T2 - 2009 Meeting on Innovations in Cardiovascular Interventions (ICI 2009) AN - 42261965; 5617083 JF - 2009 Meeting on Innovations in Cardiovascular Interventions (ICI 2009) AU - Lederman, Robert Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Intervention KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42261965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Meeting+on+Innovations+in+Cardiovascular+Interventions+%28ICI+2009%29&rft.atitle=Hibrid+Imaging+and+New+Roads+to+Interventions&rft.au=Lederman%2C+Robert&rft.aulast=Lederman&rft.aufirst=Robert&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Meeting+on+Innovations+in+Cardiovascular+Interventions+%28ICI+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/ici2009/images/stories/last_program_ici_06.1 2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Common Functional Polymorphisms of Disrupted-in-Schizophrenia-1 (DISC1) and Structural Maturation of the Cortex During Childhood and Adolescence T2 - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AN - 42258472; 5613323 JF - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AU - Raznahan, Armin AU - Lee, Yohan AU - Long, Robert AU - Greenstein, Dede AU - LaLonde, Francois AU - Clasen, Liv AU - Shaw, Phillip AU - Rapoport, Judy AU - Giedd, Jay Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Children KW - Adolescence KW - Cortex KW - DISC1 protein KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42258472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.atitle=Common+Functional+Polymorphisms+of+Disrupted-in-Schizophrenia-1+%28DISC1%29+and+Structural+Maturation+of+the+Cortex+During+Childhood+and+Adolescence&rft.au=Raznahan%2C+Armin%3BLee%2C+Yohan%3BLong%2C+Robert%3BGreenstein%2C+Dede%3BLaLonde%2C+Francois%3BClasen%2C+Liv%3BShaw%2C+Phillip%3BRapoport%2C+Judy%3BGiedd%2C+Jay&rft.aulast=Raznahan&rft.aufirst=Armin&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/asset.axd?id=a55d7404-334e-43df-a40c-9cda68719743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Common, Population-Specific Stop Codon in HTR2B Co-Segregates with Severe Impulsivity T2 - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AN - 42258431; 5613316 JF - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AU - Bevilacqua, Laura AU - Yuan, Qiaoping AU - Tikkanen, Roope AU - Zhou, Zhifeng AU - Hodgkinson, Colin AU - Coccaro, Emil AU - Virkkunen, Matti AU - Goldman, David Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Stop codon KW - Impulsive behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42258431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Epigenetics&rft.atitle=RNAi-mediated+Epigenetic+Control+of+the+Genome&rft.au=Grewal%2C+Shiv&rft.aulast=Grewal&rft.aufirst=Shiv&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Epigenetics&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/asset.axd?id=a55d7404-334e-43df-a40c-9cda68719743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurocircuitry of Mood Disorders T2 - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AN - 42258124; 5613307 JF - 48th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2009) AU - Drevets, Wayne AU - Price, Joseph Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - Mood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42258124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.atitle=Neurocircuitry+of+Mood+Disorders&rft.au=Drevets%2C+Wayne%3BPrice%2C+Joseph&rft.aulast=Drevets&rft.aufirst=Wayne&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/asset.axd?id=a55d7404-334e-43df-a40c-9cda68719743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanoscale Protein Organization in Focal Adhesions T2 - American Society for Cell Biology 49th Annual Meeting AN - 42336167; 5648635 JF - American Society for Cell Biology 49th Annual Meeting AU - Kanchanawong, P AU - Shtengel, G AU - Ramko, E AU - Davidson, M AU - Hess, H AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42336167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Nanoscale+Protein+Organization+in+Focal+Adhesions&rft.au=Kanchanawong%2C+P%3BShtengel%2C+G%3BRamko%2C+E%3BDavidson%2C+M%3BHess%2C+H%3BWaterman%2C+C&rft.aulast=Kanchanawong&rft.aufirst=P&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Key to Reorganizing Organelles during Muscle Differentiation: Centrosomal Proteins, Yes, Microtubules, No T2 - American Society for Cell Biology 49th Annual Meeting AN - 42335266; 5648846 JF - American Society for Cell Biology 49th Annual Meeting AU - Zaal, K AU - Reid, E AU - Zhang, T AU - Ralston, E Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Muscles KW - Differentiation KW - Microtubules KW - Organelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42335266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=The+Key+to+Reorganizing+Organelles+during+Muscle+Differentiation%3A+Centrosomal+Proteins%2C+Yes%2C+Microtubules%2C+No&rft.au=Zaal%2C+K%3BReid%2C+E%3BZhang%2C+T%3BRalston%2C+E&rft.aulast=Zaal&rft.aufirst=K&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolution of Drug Resistance in Cancer Cells T2 - American Society for Cell Biology 49th Annual Meeting AN - 42335178; 5646929 JF - American Society for Cell Biology 49th Annual Meeting AU - Gottesman, Michael Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Cancer KW - Drug resistance KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42335178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Evolution+of+Drug+Resistance+in+Cancer+Cells&rft.au=Gottesman%2C+Michael&rft.aulast=Gottesman&rft.aufirst=Michael&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MCAK Activity Controls Interphase Microtubule Dynamics and Directed Cell Migration T2 - American Society for Cell Biology 49th Annual Meeting AN - 42335042; 5648872 JF - American Society for Cell Biology 49th Annual Meeting AU - Myers, K AU - Applegate, K AU - Danuser, G AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Migration KW - Cell migration KW - Microtubules KW - Interphase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42335042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Genome-Wide+Association+Studies+-+New+Clues+to+Biologic+Function+in+Human+Cancer&rft.au=Hunter%2C+David&rft.aulast=Hunter&rft.aufirst=David&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bi-Directional Regulation between Microtubules and the Extracellular Matrix in Endothelial Cell Branching Morphogenesis T2 - American Society for Cell Biology 49th Annual Meeting AN - 42335001; 5648871 JF - American Society for Cell Biology 49th Annual Meeting AU - Myers, K AU - Applegate, K AU - Fischer, R AU - Danuser, G AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Endothelial cells KW - Microtubules KW - Extracellular matrix KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42335001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Bi-Directional+Regulation+between+Microtubules+and+the+Extracellular+Matrix+in+Endothelial+Cell+Branching+Morphogenesis&rft.au=Myers%2C+K%3BApplegate%2C+K%3BFischer%2C+R%3BDanuser%2C+G%3BWaterman%2C+C&rft.aulast=Myers&rft.aufirst=K&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The ERAD Inhibitor EerI Inhibits a p97-Associated Ubiquitin Processing Reaction to Induce Cancer Cell Death T2 - American Society for Cell Biology 49th Annual Meeting AN - 42333108; 5648697 JF - American Society for Cell Biology 49th Annual Meeting AU - Wang, Q AU - Trenkle, W AU - Wiestner, A AU - Ye, Y. Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Cancer KW - Mortality KW - Cell death KW - Ubiquitin KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42333108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=The+ERAD+Inhibitor+EerI+Inhibits+a+p97-Associated+Ubiquitin+Processing+Reaction+to+Induce+Cancer+Cell+Death&rft.au=Wang%2C+Q%3BTrenkle%2C+W%3BWiestner%2C+A%3BYe%2C+Y.&rft.aulast=Wang&rft.aufirst=Q&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Paxillin Phosphorylation Is a Local Regulator of Mechanotrandsuction within Individual Focal Adhesions T2 - American Society for Cell Biology 49th Annual Meeting AN - 42332461; 5646975 JF - American Society for Cell Biology 49th Annual Meeting AU - Plotnikov, Sergey Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - Phosphorylation KW - Paxillin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42332461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Paxillin+Phosphorylation+Is+a+Local+Regulator+of+Mechanotrandsuction+within+Individual+Focal+Adhesions&rft.au=Plotnikov%2C+Sergey&rft.aulast=Plotnikov&rft.aufirst=Sergey&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Fas Ligand Trafficking and Function in T Lymphocytes T2 - American Society for Cell Biology 49th Annual Meeting AN - 42332063; 5648536 JF - American Society for Cell Biology 49th Annual Meeting AU - Lee, J AU - Cleland, S AU - Griffiths, G AU - Siegel, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - Lymphocytes KW - FasL protein KW - Lymphocytes T KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42332063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Regulation+of+Fas+Ligand+Trafficking+and+Function+in+T+Lymphocytes&rft.au=Lee%2C+J%3BCleland%2C+S%3BGriffiths%2C+G%3BSiegel%2C+R&rft.aulast=Lee&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stable Adhesions Form between Cilia of Mammalian Cells. T2 - American Society for Cell Biology 49th Annual Meeting AN - 42332031; 5648903 JF - American Society for Cell Biology 49th Annual Meeting AU - Ott, C AU - Elia, N AU - Sengupta, P AU - Lippincott-Schwartz, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - Mammalian cells KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42332031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Stable+Adhesions+Form+between+Cilia+of+Mammalian+Cells.&rft.au=Ott%2C+C%3BElia%2C+N%3BSengupta%2C+P%3BLippincott-Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autophagosome Biogenesis and Function T2 - American Society for Cell Biology 49th Annual Meeting AN - 42331424; 5647069 JF - American Society for Cell Biology 49th Annual Meeting AU - Lippincott-Schwartz, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Phagosomes KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42331424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Autophagosome+Biogenesis+and+Function&rft.au=Lippincott-Schwartz%2C+J&rft.aulast=Lippincott-Schwartz&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nicotinic ACh Receptors in the Brain; Structure, Function, and Role in Disease T2 - American Society for Cell Biology 49th Annual Meeting AN - 42331368; 5647058 JF - American Society for Cell Biology 49th Annual Meeting AU - Yakel, Jerrel Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Brain KW - Structure-function relationships KW - Receptor mechanisms KW - Functional anatomy KW - Acetylcholine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42331368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Nicotinic+ACh+Receptors+in+the+Brain%3B+Structure%2C+Function%2C+and+Role+in+Disease&rft.au=Yakel%2C+Jerrel&rft.aulast=Yakel&rft.aufirst=Jerrel&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Subcellular Distribution of a Multimeric Protein Complex Encompassing Hsp90alpha T2 - American Society for Cell Biology 49th Annual Meeting AN - 42331114; 5648708 JF - American Society for Cell Biology 49th Annual Meeting AU - Song, S AU - Bernier, M Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42331114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Identification+and+Subcellular+Distribution+of+a+Multimeric+Protein+Complex+Encompassing+Hsp90alpha&rft.au=Song%2C+S%3BBernier%2C+M&rft.aulast=Song&rft.aufirst=S&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Evolutionary Side to Cancer - Physical Sciences in Oncology Perspective T2 - American Society for Cell Biology 49th Annual Meeting AN - 42330976; 5646926 JF - American Society for Cell Biology 49th Annual Meeting AU - Nagahara, Larry Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Cancer KW - Oncology KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42330976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=An+Evolutionary+Side+to+Cancer+-+Physical+Sciences+in+Oncology+Perspective&rft.au=Nagahara%2C+Larry&rft.aulast=Nagahara&rft.aufirst=Larry&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Granule Exocytosis in the Salivary Glands of Live Mice Occurs via Acto-Myosin Associated Fusion Events Not Involving Compound Exocytosis T2 - American Society for Cell Biology 49th Annual Meeting AN - 42330362; 5648569 JF - American Society for Cell Biology 49th Annual Meeting AU - Masedunskas, A AU - Weigert, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Mice KW - Exocytosis KW - Salivary gland KW - Granules KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42330362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Granule+Exocytosis+in+the+Salivary+Glands+of+Live+Mice+Occurs+via+Acto-Myosin+Associated+Fusion+Events+Not+Involving+Compound+Exocytosis&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Late Stages of Cell-To-Cell Fusion Initiated by Viral Fusogens Involve Intracellular Curvature-Generating Proteins T2 - American Society for Cell Biology 49th Annual Meeting AN - 42330331; 5648558 JF - American Society for Cell Biology 49th Annual Meeting AU - Richard, J AU - Leikina, E AU - Langen, R AU - Chernomordik, L Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42330331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Late+Stages+of+Cell-To-Cell+Fusion+Initiated+by+Viral+Fusogens+Involve+Intracellular+Curvature-Generating+Proteins&rft.au=Richard%2C+J%3BLeikina%2C+E%3BLangen%2C+R%3BChernomordik%2C+L&rft.aulast=Richard&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trafficking of Golgi- Resident Enzymes Studied by Rapamycin- Induced Protein Dimerization and Photoactivable Golgi Enzymes T2 - American Society for Cell Biology 49th Annual Meeting AN - 42330265; 5649255 JF - American Society for Cell Biology 49th Annual Meeting AU - Sengupta, P AU - Lippincott-Schwartz, J AU - Patterson, G Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Enzymes KW - Trafficking KW - Golgi apparatus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42330265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Trafficking+of+Golgi-+Resident+Enzymes+Studied+by+Rapamycin-+Induced+Protein+Dimerization+and+Photoactivable+Golgi+Enzymes&rft.au=Bago%2C+A+G%3BDimitrov%2C+E%3BSaunders%2C+R%3BSeress%2C+L%3BPalkovits%2C+M%3BUsdin%2C+T+B%3BDobolyi%2C+A&rft.aulast=Bago&rft.aufirst=A&rft.date=2009-08-04&rft.volume=162&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.04.054 L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wnt-Frizzled Signaling during Retinal Development T2 - American Society for Cell Biology 49th Annual Meeting AN - 42329665; 5648245 JF - American Society for Cell Biology 49th Annual Meeting AU - Liu, C AU - Bakeri, H AU - Veleri, S AU - Nathans, J AU - Swaroop, A Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Signal transduction KW - Retina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42329665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Wnt-Frizzled+Signaling+during+Retinal+Development&rft.au=Liu%2C+C%3BBakeri%2C+H%3BVeleri%2C+S%3BNathans%2C+J%3BSwaroop%2C+A&rft.aulast=Liu&rft.aufirst=C&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of the Salmonella Containing Vacuole with Lysosomal Hydrolases and the Retromer Complex T2 - American Society for Cell Biology 49th Annual Meeting AN - 42329111; 5649276 JF - American Society for Cell Biology 49th Annual Meeting AU - Malik-Kale, P AU - Winfree, S AU - Steele- Mortimer, O Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Vacuoles KW - Hydrolase KW - Anadromous species KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42329111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Interaction+of+the+Salmonella+Containing+Vacuole+with+Lysosomal+Hydrolases+and+the+Retromer+Complex&rft.au=Malik-Kale%2C+P%3BWinfree%2C+S%3BSteele-+Mortimer%2C+O&rft.aulast=Malik-Kale&rft.aufirst=P&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of p120-Catenin Is Post-Transcriptionally Regulated by Cdk5 T2 - American Society for Cell Biology 49th Annual Meeting AN - 42329084; 5649104 JF - American Society for Cell Biology 49th Annual Meeting AU - Parthasarathy, A AU - Gao, C AU - Saravanamuthu, S AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Cyclin-dependent kinase 5 KW - Post-transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42329084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Expression+of+p120-Catenin+Is+Post-Transcriptionally+Regulated+by+Cdk5&rft.au=Parthasarathy%2C+A%3BGao%2C+C%3BSaravanamuthu%2C+S%3BZelenka%2C+P&rft.aulast=Parthasarathy&rft.aufirst=A&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Single Integrin Behavior in Living Cells T2 - American Society for Cell Biology 49th Annual Meeting AN - 42328642; 5648331 JF - American Society for Cell Biology 49th Annual Meeting AU - Kanchanawong, P AU - Hou, J AU - Zajac, A AU - Aguet, F AU - Davidson, M AU - Danuser, G AU - Jaqaman, K AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Integrins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42328642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Analysis+of+Single+Integrin+Behavior+in+Living+Cells&rft.au=Kanchanawong%2C+P%3BHou%2C+J%3BZajac%2C+A%3BAguet%2C+F%3BDavidson%2C+M%3BDanuser%2C+G%3BJaqaman%2C+K%3BWaterman%2C+C&rft.aulast=Kanchanawong&rft.aufirst=P&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coordinated Dynein- Mediated Transport and Membrane Trafficking of Late Endocytic Organelles Is Essential for Proper Autophagy-Lysosomal Function in Neurons T2 - American Society for Cell Biology 49th Annual Meeting AN - 42328488; 5649265 JF - American Society for Cell Biology 49th Annual Meeting AU - Cai, Q AU - Lu, L. AU - Tian, J AU - Zhu, Y AU - Sheng, Z Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - Membranes KW - Organelles KW - Neurons KW - Membrane trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42328488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Coordinated+Dynein-+Mediated+Transport+and+Membrane+Trafficking+of+Late+Endocytic+Organelles+Is+Essential+for+Proper+Autophagy-Lysosomal+Function+in+Neurons&rft.au=Cai%2C+Q%3BLu%2C+L.%3BTian%2C+J%3BZhu%2C+Y%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microtubule Organization and Dynamics in Skeletal Muscle: Microtubules under New Management? T2 - American Society for Cell Biology 49th Annual Meeting AN - 42328211; 5648121 JF - American Society for Cell Biology 49th Annual Meeting AU - Tate, V AU - Ralston, E Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Skeletal muscle KW - Microtubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42328211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Microtubule+Organization+and+Dynamics+in+Skeletal+Muscle%3A+Microtubules+under+New+Management%3F&rft.au=Tate%2C+V%3BRalston%2C+E&rft.aulast=Tate&rft.aufirst=V&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Calcium Channel MCOLN3 Regulates Endosomal Acidification T2 - American Society for Cell Biology 49th Annual Meeting AN - 42327697; 5649272 JF - American Society for Cell Biology 49th Annual Meeting AU - Lelouvier, B AU - Puertollano, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Acidification KW - Calcium channels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42327697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=The+Calcium+Channel+MCOLN3+Regulates+Endosomal+Acidification&rft.au=Lelouvier%2C+B%3BPuertollano%2C+R&rft.aulast=Lelouvier&rft.aufirst=B&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MARCH Proteins Promote Delivery of Clathrin-Independent Endocytic Cargo Proteins MHCI and CD98 to Late Endosomes T2 - American Society for Cell Biology 49th Annual Meeting AN - 42327651; 5649318 JF - American Society for Cell Biology 49th Annual Meeting AU - Eyster, C AU - Viswanathan, K AU - Frueh, K AU - Donaldson, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Endosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42327651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=MARCH+Proteins+Promote+Delivery+of+Clathrin-Independent+Endocytic+Cargo+Proteins+MHCI+and+CD98+to+Late+Endosomes&rft.au=Eyster%2C+C%3BViswanathan%2C+K%3BFrueh%2C+K%3BDonaldson%2C+J&rft.aulast=Eyster&rft.aufirst=C&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphatidylinositol-4,5- Bisphosphate 4-Phosphatase Interacts with MCOLN3 and Is Involved in the Trafficking of Cargo Proteins Along the Endo/Lysosomal Compartment T2 - American Society for Cell Biology 49th Annual Meeting AN - 42327613; 5649274 JF - American Society for Cell Biology 49th Annual Meeting AU - Martina, J AU - Puertollano, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42327613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Phosphatidylinositol-4%2C5-+Bisphosphate+4-Phosphatase+Interacts+with+MCOLN3+and+Is+Involved+in+the+Trafficking+of+Cargo+Proteins+Along+the+Endo%2FLysosomal+Compartment&rft.au=Martina%2C+J%3BPuertollano%2C+R&rft.aulast=Martina&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Choosing the Right Photoactivatable Fluorescent Protein for the Job T2 - American Society for Cell Biology 49th Annual Meeting AN - 42326985; 5649350 JF - American Society for Cell Biology 49th Annual Meeting AU - Galbraith, J AU - Galbraith, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42326985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Choosing+the+Right+Photoactivatable+Fluorescent+Protein+for+the+Job&rft.au=Galbraith%2C+J%3BGalbraith%2C+C&rft.aulast=Galbraith&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function of Nonmuscle Myosin II Isoforms in LPA1-Induced Migration and Invasion T2 - American Society for Cell Biology 49th Annual Meeting AN - 42326874; 5648192 JF - American Society for Cell Biology 49th Annual Meeting AU - Kim, J AU - Adelstein, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Migration KW - Invasions KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42326874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Function+of+Nonmuscle+Myosin+II+Isoforms+in+LPA1-Induced+Migration+and+Invasion&rft.au=Kim%2C+J%3BAdelstein%2C+R&rft.aulast=Kim&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role Notch Signaling Pathway in Ocular Lens Development and Pathology T2 - American Society for Cell Biology 49th Annual Meeting AN - 42326604; 5649057 JF - American Society for Cell Biology 49th Annual Meeting AU - Saravanamuthu, S AU - Brown, N AU - Gao, C AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Pathology KW - Signal transduction KW - Notch protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42326604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Role+Notch+Signaling+Pathway+in+Ocular+Lens+Development+and+Pathology&rft.au=Saravanamuthu%2C+S%3BBrown%2C+N%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Saravanamuthu&rft.aufirst=S&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - mTORC2-Mediated AC9 Activation Is Required for Chemoattractant- Induced Camp Production and Chemotaxis in Neutrophils T2 - American Society for Cell Biology 49th Annual Meeting AN - 42326446; 5648989 JF - American Society for Cell Biology 49th Annual Meeting AU - Liu, L AU - Das, S AU - Losert, W AU - Parent, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Leukocytes (neutrophilic) KW - Cyclic AMP KW - Cell activation KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42326446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=mTORC2-Mediated+AC9+Activation+Is+Required+for+Chemoattractant-+Induced+Camp+Production+and+Chemotaxis+in+Neutrophils&rft.au=Liu%2C+L%3BDas%2C+S%3BLosert%2C+W%3BParent%2C+C&rft.aulast=Liu&rft.aufirst=L&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Limits Src Activity by Targeting C-Src for Ubiquitin-Dependent Degradation T2 - American Society for Cell Biology 49th Annual Meeting AN - 42325864; 5647339 JF - American Society for Cell Biology 49th Annual Meeting AU - Qiao, F AU - Pan, Q AU - Gao, C AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Degradation KW - Src protein KW - Ubiquitin KW - Cyclin-dependent kinase 5 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42325864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Cdk5+Limits+Src+Activity+by+Targeting+C-Src+for+Ubiquitin-Dependent+Degradation&rft.au=Qiao%2C+F%3BPan%2C+Q%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Qiao&rft.aufirst=F&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Sorting Determinants Guide the Trafficking Itinerary of the New Clathrin-Independent Endocytic Cargo Proteins CD44 and CD147 T2 - American Society for Cell Biology 49th Annual Meeting AN - 42325663; 5649322 JF - American Society for Cell Biology 49th Annual Meeting AU - Maldonado-Baez, L AU - Cole, N AU - Eyster, C AU - Donaldson, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - CD147 antigen KW - CD44 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42325663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Distinct+Sorting+Determinants+Guide+the+Trafficking+Itinerary+of+the+New+Clathrin-Independent+Endocytic+Cargo+Proteins+CD44+and+CD147&rft.au=Maldonado-Baez%2C+L%3BCole%2C+N%3BEyster%2C+C%3BDonaldson%2C+J&rft.aulast=Maldonado-Baez&rft.aufirst=L&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Homozygous Deletion of Pdlim2 Is Associated with Structural Abnormalities of Corneal Epithelia and Increased Levels of Cytoskeletal and Chaperone Proteins T2 - American Society for Cell Biology 49th Annual Meeting AN - 42325540; 5648174 JF - American Society for Cell Biology 49th Annual Meeting AU - Gao, C AU - Saravanamuthu, S AU - Tomarev, S AU - Grusby, M AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Cytoskeleton KW - Gene deletion KW - Chaperones KW - Cornea KW - Epithelia KW - Abnormalities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42325540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Homozygous+Deletion+of+Pdlim2+Is+Associated+with+Structural+Abnormalities+of+Corneal+Epithelia+and+Increased+Levels+of+Cytoskeletal+and+Chaperone+Proteins&rft.au=Gao%2C+C%3BSaravanamuthu%2C+S%3BTomarev%2C+S%3BGrusby%2C+M%3BZelenka%2C+P&rft.aulast=Gao&rft.aufirst=C&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Epigenetics (Dnmt- 1-Mediated DNA Methylation) in Retinal Differentiation T2 - American Society for Cell Biology 49th Annual Meeting AN - 42325091; 5649025 JF - American Society for Cell Biology 49th Annual Meeting AU - Nasonkin, I AU - Hambright, D AU - Rachel, R AU - Jamrich, M AU - Jaenisch, R AU - Fariss, R AU - Swaroop, A Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Retina KW - Differentiation KW - DNA methylation KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42325091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Role+of+Epigenetics+%28Dnmt-+1-Mediated+DNA+Methylation%29+in+Retinal+Differentiation&rft.au=Nasonkin%2C+I%3BHambright%2C+D%3BRachel%2C+R%3BJamrich%2C+M%3BJaenisch%2C+R%3BFariss%2C+R%3BSwaroop%2C+A&rft.aulast=Nasonkin&rft.aufirst=I&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Neuronal Nuclei (NeuN) as Fox-3 which Plays a Role in the Alternative Splicing of Non-Muscle Myosin Heavy Chain Ii-B T2 - American Society for Cell Biology 49th Annual Meeting AN - 42325050; 5649024 JF - American Society for Cell Biology 49th Annual Meeting AU - Kim, K AU - Adelstein, R AU - Kawamoto, S Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Myosin KW - Alternative splicing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42325050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Identification+of+Neuronal+Nuclei+%28NeuN%29+as+Fox-3+which+Plays+a+Role+in+the+Alternative+Splicing+of+Non-Muscle+Myosin+Heavy+Chain+Ii-B&rft.au=Kim%2C+K%3BAdelstein%2C+R%3BKawamoto%2C+S&rft.aulast=Kim&rft.aufirst=K&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Regulates Rho- Dependent Cytoskeletal Contraction and Epithelial Cell Migration by Suppressing Activities of Src and P190RhoGAP T2 - American Society for Cell Biology 49th Annual Meeting AN - 42324592; 5648191 JF - American Society for Cell Biology 49th Annual Meeting AU - Tripathi, B AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Migration KW - Src protein KW - Cytoskeleton KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42324592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Genetic+Recombination+and+Genome+Rearrangements&rft.atitle=Control+of+joint+molecule+resolution&rft.au=Lichten%2C+Michael&rft.aulast=Lichten&rft.aufirst=Michael&rft.date=2009-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genetic+Recombination+and+Genome+Rearrangements&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An RNAi Screen of Microtubule-Regulatory Proteins Identifies MARK2/Par1 as an Effector of Rac1- Mediated Microtubule Growth T2 - American Society for Cell Biology 49th Annual Meeting AN - 42324171; 5648954 JF - American Society for Cell Biology 49th Annual Meeting AU - Nishimura, Y AU - Applegate, K AU - Danuser, G AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - RNA-mediated interference KW - Protein-serine/threonine kinase KW - Microtubules KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42324171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=An+RNAi+Screen+of+Microtubule-Regulatory+Proteins+Identifies+MARK2%2FPar1+as+an+Effector+of+Rac1-+Mediated+Microtubule+Growth&rft.au=Nishimura%2C+Y%3BApplegate%2C+K%3BDanuser%2C+G%3BWaterman%2C+C&rft.aulast=Nishimura&rft.aufirst=Y&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Analysis of Myosin II-Mediated Focal Adhesion Maturation Reveals a Role for beta-Pix in Relaxation-Mediated Rac1 Activation T2 - American Society for Cell Biology 49th Annual Meeting AN - 42324143; 5647463 JF - American Society for Cell Biology 49th Annual Meeting AU - Kuo, J AU - Han, X AU - Yates, J AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - Rac1 protein KW - Myosin KW - Proteomics KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42324143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Proteomic+Analysis+of+Myosin+II-Mediated+Focal+Adhesion+Maturation+Reveals+a+Role+for+beta-Pix+in+Relaxation-Mediated+Rac1+Activation&rft.au=Kuo%2C+J%3BHan%2C+X%3BYates%2C+J%3BWaterman%2C+C&rft.aulast=Kuo&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Rac1, RhoA, and Cdc42 Activity during Cell Migration within Three-Dimensional Extracellular Matrix T2 - American Society for Cell Biology 49th Annual Meeting AN - 42323753; 5647363 JF - American Society for Cell Biology 49th Annual Meeting AU - Petrie, R AU - Yamada, K Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Migration KW - RhoA protein KW - Rac1 protein KW - Cell migration KW - Extracellular matrix KW - Cdc42 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42323753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Visualizing+Rac1%2C+RhoA%2C+and+Cdc42+Activity+during+Cell+Migration+within+Three-Dimensional+Extracellular+Matrix&rft.au=Petrie%2C+R%3BYamada%2C+K&rft.aulast=Petrie&rft.aufirst=R&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sumoylation Modulates the Transcriptional Regulatory Function of Rod Differentiation Factor NRL T2 - American Society for Cell Biology 49th Annual Meeting AN - 42323623; 5649027 JF - American Society for Cell Biology 49th Annual Meeting AU - Roger, J AU - Nellissery, J AU - Kim, D AU - Swaroop, A Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Differentiation KW - Transcription KW - SUMO protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42323623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Sumoylation+Modulates+the+Transcriptional+Regulatory+Function+of+Rod+Differentiation+Factor+NRL&rft.au=Roger%2C+J%3BNellissery%2C+J%3BKim%2C+D%3BSwaroop%2C+A&rft.aulast=Roger&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ubiquitination Regulates MHC Class II Recycling and MHC Class IIPeptide Complex Expression in Dendritic Cells T2 - American Society for Cell Biology 49th Annual Meeting AN - 42323595; 5649390 JF - American Society for Cell Biology 49th Annual Meeting AU - Walseng, E AU - Furuta, K AU - Faust, K AU - Matsuki, Y AU - Bakke, O AU - Ishido, S AU - Roche, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Recycling KW - Waste management KW - Major histocompatibility complex KW - Dendritic cells KW - Ubiquitination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42323595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Ubiquitination+Regulates+MHC+Class+II+Recycling+and+MHC+Class+IIPeptide+Complex+Expression+in+Dendritic+Cells&rft.au=Walseng%2C+E%3BFuruta%2C+K%3BFaust%2C+K%3BMatsuki%2C+Y%3BBakke%2C+O%3BIshido%2C+S%3BRoche%2C+P&rft.aulast=Walseng&rft.aufirst=E&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Traction Stress Variation Across Single Focal Adhesions T2 - American Society for Cell Biology 49th Annual Meeting AN - 42322985; 5647470 JF - American Society for Cell Biology 49th Annual Meeting AU - Plotnikov, S AU - Sabass, B AU - Schwarz, U AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Stress KW - Adhesion KW - Traction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42322985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Analysis+of+Traction+Stress+Variation+Across+Single+Focal+Adhesions&rft.au=Plotnikov%2C+S%3BSabass%2C+B%3BSchwarz%2C+U%3BWaterman%2C+C&rft.aulast=Plotnikov&rft.aufirst=S&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systemic Delivery of Bioactive Glucagon-Like Peptide 1 Following Adenoviral Mediated Gene Transfer in the Murine Salivary Gland T2 - American Society for Cell Biology 49th Annual Meeting AN - 42322672; 5647909 JF - American Society for Cell Biology 49th Annual Meeting AU - Cawley, N AU - Voutetakis, A AU - Cotrim, A AU - Rowzee, A AU - Rathod, T AU - Zheng, C AU - Loh, Y AU - Baum, B Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Gene transfer KW - Salivary gland KW - Glucagon-like peptide 1 KW - Peptides KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42322672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Systemic+Delivery+of+Bioactive+Glucagon-Like+Peptide+1+Following+Adenoviral+Mediated+Gene+Transfer+in+the+Murine+Salivary+Gland&rft.au=Cawley%2C+N%3BVoutetakis%2C+A%3BCotrim%2C+A%3BRowzee%2C+A%3BRathod%2C+T%3BZheng%2C+C%3BLoh%2C+Y%3BBaum%2C+B&rft.aulast=Cawley&rft.aufirst=N&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Relationship between Yeast Nuclear Morphology, Large Structural Nucleoporins, and the SUN Domain Protein MPS3 T2 - American Society for Cell Biology 49th Annual Meeting AN - 42322477; 5647536 JF - American Society for Cell Biology 49th Annual Meeting AU - Witkin, K AU - Cohen-Fix, O AU - Jaspersen, S Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Sun KW - Morphology KW - Nucleoporins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42322477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=A+Relationship+between+Yeast+Nuclear+Morphology%2C+Large+Structural+Nucleoporins%2C+and+the+SUN+Domain+Protein+MPS3&rft.au=Witkin%2C+K%3BCohen-Fix%2C+O%3BJaspersen%2C+S&rft.aulast=Witkin&rft.aufirst=K&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Tubulin- Membrane Interaction by Tubulin's Carboxy- Terminal Tails T2 - American Society for Cell Biology 49th Annual Meeting AN - 42322313; 5647279 JF - American Society for Cell Biology 49th Annual Meeting AU - Sackett, D Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Membranes KW - Tails KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42322313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Regulation+of+Tubulin-+Membrane+Interaction+by+Tubulin%27s+Carboxy-+Terminal+Tails&rft.au=Sackett%2C+D&rft.aulast=Sackett&rft.aufirst=D&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vinculin Stabilizes Nascent Adhesions and Establishes the Lamellipodium-Lamella Border in Migrating Cells T2 - American Society for Cell Biology 49th Annual Meeting AN - 42321823; 5647469 JF - American Society for Cell Biology 49th Annual Meeting AU - Thievessen, I AU - Berlemont, S AU - Zemljic-Harpf, A AU - Ross, R AU - Waterman, C Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - Vinculin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42321823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Vinculin+Stabilizes+Nascent+Adhesions+and+Establishes+the+Lamellipodium-Lamella+Border+in+Migrating+Cells&rft.au=Thievessen%2C+I%3BBerlemont%2C+S%3BZemljic-Harpf%2C+A%3BRoss%2C+R%3BWaterman%2C+C&rft.aulast=Thievessen&rft.aufirst=I&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp106 L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5(Y15) Phosphorylation Is Required for Src Activation and Localization at Focal Adhesions T2 - American Society for Cell Biology 49th Annual Meeting AN - 42321790; 5647466 JF - American Society for Cell Biology 49th Annual Meeting AU - Pan, Q AU - Gao, C AU - Parthasarathy, A AU - Zelenka, P Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Adhesion KW - Src protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42321790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Cdk5%28Y15%29+Phosphorylation+Is+Required+for+Src+Activation+and+Localization+at+Focal+Adhesions&rft.au=Pan%2C+Q%3BGao%2C+C%3BParthasarathy%2C+A%3BZelenka%2C+P&rft.aulast=Pan&rft.aufirst=Q&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bile Acids Regulate Bile Canalicular Formation in Primary Hepatocytes T2 - American Society for Cell Biology 49th Annual Meeting AN - 42321692; 5647413 JF - American Society for Cell Biology 49th Annual Meeting AU - Fu, D AU - Wakabayashi, Y AU - Lippincott-Schwartz, J AU - Arias, I Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Bile acids KW - Hepatocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42321692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Bile+Acids+Regulate+Bile+Canalicular+Formation+in+Primary+Hepatocytes&rft.au=Fu%2C+D%3BWakabayashi%2C+Y%3BLippincott-Schwartz%2C+J%3BArias%2C+I&rft.aulast=Fu&rft.aufirst=D&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The J-Domain and Clathrin Binding Domains Alone Are Sufficient for GAK Activity T2 - American Society for Cell Biology 49th Annual Meeting AN - 42321569; 5647776 JF - American Society for Cell Biology 49th Annual Meeting AU - Park, B AU - Zhao, X AU - Eisenberg, E AU - Greene, L Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Clathrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42321569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=The+J-Domain+and+Clathrin+Binding+Domains+Alone+Are+Sufficient+for+GAK+Activity&rft.au=Park%2C+B%3BZhao%2C+X%3BEisenberg%2C+E%3BGreene%2C+L&rft.aulast=Park&rft.aufirst=B&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Actin Tyr-53 Mutants Inhibit Chemotactic Signaling in Dictyostelium T2 - American Society for Cell Biology 49th Annual Meeting AN - 42321460; 5647328 JF - American Society for Cell Biology 49th Annual Meeting AU - Shu, S AU - Liu, X AU - Kriebel, P AU - Parent, C AU - Korn, E Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Mutants KW - Signal transduction KW - Actin KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42321460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Actin+Tyr-53+Mutants+Inhibit+Chemotactic+Signaling+in+Dictyostelium&rft.au=Shu%2C+S%3BLiu%2C+X%3BKriebel%2C+P%3BParent%2C+C%3BKorn%2C+E&rft.aulast=Shu&rft.aufirst=S&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rab11a and Myosin Vb Are Required for Canalicular Network Formation in Rat Hepatocytes T2 - American Society for Cell Biology 49th Annual Meeting AN - 42320573; 5647414 JF - American Society for Cell Biology 49th Annual Meeting AU - Wakabayashi, Y AU - Fu, D. AU - Lippincott-Schwartz, J AU - Arias, I Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Myosin KW - Hepatocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42320573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Rab11a+and+Myosin+Vb+Are+Required+for+Canalicular+Network+Formation+in+Rat+Hepatocytes&rft.au=Wakabayashi%2C+Y%3BFu%2C+D.%3BLippincott-Schwartz%2C+J%3BArias%2C+I&rft.aulast=Wakabayashi&rft.aufirst=Y&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Divalent Interaction between Hps1 and Hps4 to Form the Biogenesis of Lysosome-Related Organelles 3 (Bloc-3) T2 - American Society for Cell Biology 49th Annual Meeting AN - 42320522; 5647951 JF - American Society for Cell Biology 49th Annual Meeting AU - Carmona-Rivera, C AU - Bonifacino, J AU - Cadilla, C AU - Gahl, W Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Organelles KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42320522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Divalent+Interaction+between+Hps1+and+Hps4+to+Form+the+Biogenesis+of+Lysosome-Related+Organelles+3+%28Bloc-3%29&rft.au=Carmona-Rivera%2C+C%3BBonifacino%2C+J%3BCadilla%2C+C%3BGahl%2C+W&rft.aulast=Carmona-Rivera&rft.aufirst=C&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Insights into Dynamin GTP Hydrolysis T2 - American Society for Cell Biology 49th Annual Meeting AN - 42320386; 5647768 JF - American Society for Cell Biology 49th Annual Meeting AU - Chappie, J AU - Schmid, S AU - Dyda, F Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Hydrolysis KW - GTP KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42320386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Structural+Insights+into+Dynamin+GTP+Hydrolysis&rft.au=Chappie%2C+J%3BSchmid%2C+S%3BDyda%2C+F&rft.aulast=Chappie&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conditional Ablation of Nonmuscle Myosin II-B in Mice Results in Arrhythmogenic Right Ventricular Cardiomyopathy Associated with Defects in the Coronary Circulation T2 - American Society for Cell Biology 49th Annual Meeting AN - 42320367; 5647251 JF - American Society for Cell Biology 49th Annual Meeting AU - Ma, X. AU - Ikebe, M AU - Anderson, S AU - Adelstein, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Mice KW - Ventricle KW - Cardiomyopathy KW - Myosin KW - Heart KW - Blood circulation KW - Defects KW - Circulatory system KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42320367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Conditional+Ablation+of+Nonmuscle+Myosin+II-B+in+Mice+Results+in+Arrhythmogenic+Right+Ventricular+Cardiomyopathy+Associated+with+Defects+in+the+Coronary+Circulation&rft.au=Ma%2C+X.%3BIkebe%2C+M%3BAnderson%2C+S%3BAdelstein%2C+R&rft.aulast=Ma&rft.aufirst=X.&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of [3H]Halichondrin B with Tubulin T2 - American Society for Cell Biology 49th Annual Meeting AN - 42319873; 5647272 JF - American Society for Cell Biology 49th Annual Meeting AU - Bai, R AU - Nguyen, T AU - Gussio, R AU - Hamel, E Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42319873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Interaction+of+%5B3H%5DHalichondrin+B+with+Tubulin&rft.au=Bai%2C+R%3BNguyen%2C+T%3BGussio%2C+R%3BHamel%2C+E&rft.aulast=Bai&rft.aufirst=R&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of T34 Phosphorylation in Akt Dissociation from Membrane during Akt Activation T2 - American Society for Cell Biology 49th Annual Meeting AN - 42319415; 5647602 JF - American Society for Cell Biology 49th Annual Meeting AU - Akbar, M AU - Huang, B AU - Lee, R AU - Kim, H Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Membranes KW - AKT protein KW - Phosphorylation KW - Dissociation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42319415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Role+of+T34+Phosphorylation+in+Akt+Dissociation+from+Membrane+during+Akt+Activation&rft.au=Akbar%2C+M%3BHuang%2C+B%3BLee%2C+R%3BKim%2C+H&rft.aulast=Akbar&rft.aufirst=M&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Docking Receptor Syntaphilin Is Required for Calcium- Dependent and KIF5-Miro-Mediated Immobilization of Axonal Mitochondria T2 - American Society for Cell Biology 49th Annual Meeting AN - 42319307; 5647726 JF - American Society for Cell Biology 49th Annual Meeting AU - Chen, Y AU - Sheng, Z Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Mitochondria KW - Immobilization KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42319307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Docking+Receptor+Syntaphilin+Is+Required+for+Calcium-+Dependent+and+KIF5-Miro-Mediated+Immobilization+of+Axonal+Mitochondria&rft.au=Chen%2C+Y%3BSheng%2C+Z&rft.aulast=Chen&rft.aufirst=Y&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Models of Human MYH9-Related Diseases T2 - American Society for Cell Biology 49th Annual Meeting AN - 42318989; 5647263 JF - American Society for Cell Biology 49th Annual Meeting AU - Zhang, Y AU - Conti, M AU - Kawamoto, S AU - Schmist, Y AU - Adelstein, R Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Animal models KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Mouse+Models+of+Human+MYH9-Related+Diseases&rft.au=Zhang%2C+Y%3BConti%2C+M%3BKawamoto%2C+S%3BSchmist%2C+Y%3BAdelstein%2C+R&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arf6 Contributes to Pma Induced Podosome-Like Ventral Ruffle Formation by Influencing Endosomal Membrane Trafficking T2 - American Society for Cell Biology 49th Annual Meeting AN - 42318663; 5648096 JF - American Society for Cell Biology 49th Annual Meeting AU - Cohen, L AU - Donaldson, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - Membranes KW - Phorbol esters KW - Membrane trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=CCR6+is+required+for+IL-23-induced+psoriasis-like+inflammation+in+mice.&rft.au=Hedrick%2C+Michael+N%3BLonsdorf%2C+Anke+S%3BShirakawa%2C+Aiko-Konno%3BRichard+Lee%2C+Chyi-Chia%3BLiao%2C+Fang%3BSingh%2C+Satya+P%3BZhang%2C+Hongwei+H%3BGrinberg%2C+Alexander%3BLove%2C+Paul+E%3BHwang%2C+Sam+T%3BFarber%2C+Joshua+M&rft.aulast=Hedrick&rft.aufirst=Michael&rft.date=2009-08-01&rft.volume=119&rft.issue=8&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytoplasmic Tails Delay Oligomerization of ZP2 and ZP3 Prior to Secretion and Formation of the Extracellular Zona Pellucida Surrounding Mouse Eggs T2 - American Society for Cell Biology 49th Annual Meeting AN - 42318418; 5647493 JF - American Society for Cell Biology 49th Annual Meeting AU - Jimenez-Movilla, M AU - Dean, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Eggs KW - Secretion KW - Oligomerization KW - Zona pellucida KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Cytoplasmic+Tails+Delay+Oligomerization+of+ZP2+and+ZP3+Prior+to+Secretion+and+Formation+of+the+Extracellular+Zona+Pellucida+Surrounding+Mouse+Eggs&rft.au=Jimenez-Movilla%2C+M%3BDean%2C+J&rft.aulast=Jimenez-Movilla&rft.aufirst=M&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Intracellular Trafficking of the Inhibitory Leukocyte-Associated Ig-Like Receptor-1 (LAIR-1). T2 - American Society for Cell Biology 49th Annual Meeting AN - 42318363; 5647744 JF - American Society for Cell Biology 49th Annual Meeting AU - Peruzzi, G AU - Krzewski, K AU - Borrego, F AU - Coligan, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Characterization+of+the+Intracellular+Trafficking+of+the+Inhibitory+Leukocyte-Associated+Ig-Like+Receptor-1+%28LAIR-1%29.&rft.au=Peruzzi%2C+G%3BKrzewski%2C+K%3BBorrego%2C+F%3BColigan%2C+J&rft.aulast=Peruzzi&rft.aufirst=G&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of G1-S Transition by a Hyperfused Form of Mitochondria T2 - American Society for Cell Biology 49th Annual Meeting AN - 42318026; 5647620 JF - American Society for Cell Biology 49th Annual Meeting AU - Mitra, K AU - Rikhy, R AU - Wunder, C AU - Lippincott-Schwartz, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42318026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Regulation+of+G1-S+Transition+by+a+Hyperfused+Form+of+Mitochondria&rft.au=Mitra%2C+K%3BRikhy%2C+R%3BWunder%2C+C%3BLippincott-Schwartz%2C+J&rft.aulast=Mitra&rft.aufirst=K&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hematopoietic Progenitor Cell Communication with the Niche Microenvironment Is Regulated by a Specialized Plasma Membrane Domain T2 - American Society for Cell Biology 49th Annual Meeting AN - 42317661; 5647450 JF - American Society for Cell Biology 49th Annual Meeting AU - Gillette, J AU - Larochelle, A AU - Cantilena, A AU - Cerf, A AU - Dunbar, C AU - Lippincott-Schwartz, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Niches KW - Plasma membranes KW - Communication KW - Microenvironments KW - Hemopoiesis KW - Cell interactions KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42317661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Hematopoietic+Progenitor+Cell+Communication+with+the+Niche+Microenvironment+Is+Regulated+by+a+Specialized+Plasma+Membrane+Domain&rft.au=Gillette%2C+J%3BLarochelle%2C+A%3BCantilena%2C+A%3BCerf%2C+A%3BDunbar%2C+C%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ER Stress-Induced Conversion of Brucella-Replicative Organelles into Late Endosomal Vacuoles T2 - American Society for Cell Biology 49th Annual Meeting AN - 42317555; 5647180 JF - American Society for Cell Biology 49th Annual Meeting AU - Starr, T AU - Celli, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Vacuoles KW - Organelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42317555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Overexpression+of+interleukin-13+receptor-alpha2+in+neuroendocrine+malignant+pheochromocytoma%3A+a+novel+target+for+receptor+directed+anti-cancer+therapy.&rft.au=Lai%2C+Edwin+W%3BJoshi%2C+Bharat+H%3BMartiniova%2C+Lucia%3BDogra%2C+Ritika%3BFujisawa%2C+Toshio%3BLeland%2C+Pamela%3Bde+Krijger%2C+Ronald+R%3BLubensky%2C+Irina+A%3BElkahloun%2C+Abdel+G%3BMorris%2C+John+C%3BPuri%2C+Raj+K%3BPacak%2C+Karel&rft.aulast=Lai&rft.aufirst=Edwin&rft.date=2009-08-01&rft.volume=94&rft.issue=8&rft.spage=2952&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2009-0309 L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphorylation of the Endoplasmic Reticulum Calcium Sensor STIM1 Underlies Suppression of Store- Operated Calcium Entry during Mitosis T2 - American Society for Cell Biology 49th Annual Meeting AN - 42315220; 5647606 JF - American Society for Cell Biology 49th Annual Meeting AU - Smyth, J AU - Petranka, J AU - Boyles, R AU - DeHaven, W AU - Fukushima, M AU - Johnson, K AU - Williams, J AU - Putney, J Y1 - 2009/12/05/ PY - 2009 DA - 2009 Dec 05 KW - Calcium (reticular) KW - Sensors KW - Mitosis KW - Endoplasmic reticulum KW - STIM1 protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42315220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.atitle=Phosphorylation+of+the+Endoplasmic+Reticulum+Calcium+Sensor+STIM1+Underlies+Suppression+of+Store-+Operated+Calcium+Entry+during+Mitosis&rft.au=Smyth%2C+J%3BPetranka%2C+J%3BBoyles%2C+R%3BDeHaven%2C+W%3BFukushima%2C+M%3BJohnson%2C+K%3BWilliams%2C+J%3BPutney%2C+J&rft.aulast=Smyth&rft.aufirst=J&rft.date=2009-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Society+for+Cell+Biology+49th+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/Docs/FINAL%20PROGRAM_lo%20res%20for%20web .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Corpus Callosum Abnormalities and Schneiderian First Rank Symptoms in Antipsychotic NaiVe Schizophrenia: A 3-Tesla Mri Study T2 - 4th International Congress on Brain and Behaviour and 17th Thessaloniki Conference of the South-East European Society for Neurology and Psychiatry (ISBB 2010) AN - 42279100; 5623065 JF - 4th International Congress on Brain and Behaviour and 17th Thessaloniki Conference of the South-East European Society for Neurology and Psychiatry (ISBB 2010) AU - Rao, N AU - Venkatasubramanian, G AU - Arasappa, R AU - Gangadhar, B Y1 - 2009/12/03/ PY - 2009 DA - 2009 Dec 03 KW - Neuroleptics KW - Mental disorders KW - Magnetic resonance imaging KW - Schizophrenia KW - Corpus callosum KW - Abnormalities KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42279100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+International+Congress+on+Brain+and+Behaviour+and+17th+Thessaloniki+Conference+of+the+South-East+European+Society+for+Neurology+and+Psychiatry+%28ISBB+2010%29&rft.atitle=Relationship+between+Corpus+Callosum+Abnormalities+and+Schneiderian+First+Rank+Symptoms+in+Antipsychotic+NaiVe+Schizophrenia%3A+A+3-Tesla+Mri+Study&rft.au=Rao%2C+N%3BVenkatasubramanian%2C+G%3BArasappa%2C+R%3BGangadhar%2C+B&rft.aulast=Rao&rft.aufirst=N&rft.date=2009-12-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+International+Congress+on+Brain+and+Behaviour+and+17th+Thessaloniki+Conference+of+the+South-East+European+Society+for+Neurology+and+Psychiatry+%28ISBB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbb.gr/final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels. AN - 734162581; 19948133 AB - In Alzheimer's disease, calcium permeability through cellular membranes appears to underlie neuronal cell death. It is increasingly accepted that calcium permeability involves toxic ion channels. We modeled Alzheimer's disease ion channels of different sizes (12-mer to 36-mer) in the lipid bilayer using molecular dynamics simulations. Our Abeta channels consist of the solid-state NMR-based U-shaped beta-strand-turn-beta-strand motif. In the simulations we obtain ion-permeable channels whose subunit morphologies and shapes are consistent with electron microscopy/atomic force microscopy. In agreement with imaged channels, the simulations indicate that beta-sheet channels break into loosely associated mobile beta-sheet subunits. The preferred channel sizes (16- to 24-mer) are compatible with electron microscopy/atomic force microscopy-derived dimensions. Mobile subunits were also observed for beta-sheet channels formed by cytolytic PG-1 beta-hairpins. The emerging picture from our large-scale simulations is that toxic ion channels formed by beta-sheets spontaneously break into loosely interacting dynamic units that associate and dissociate leading to toxic ionic flux. This sharply contrasts intact conventional gated ion channels that consist of tightly interacting alpha-helices that robustly prevent ion leakage, rather than hydrogen-bonded beta-strands. The simulations suggest why conventional gated channels evolved to consist of interacting alpha-helices rather than hydrogen-bonded beta-strands that tend to break in fluidic bilayers. Nature designs folded channels but not misfolded toxic channels. JF - Biophysical journal AU - Jang, Hyunbum AU - Arce, Fernando Teran AU - Capone, Ricardo AU - Ramachandran, Srinivasan AU - Lal, Ratnesh AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, NCI-Frederick, SAIC-Frederick, Frederick, Maryland, USA. jangh2@mail.nih.gov Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 SP - 3029 EP - 3037 VL - 97 IS - 11 KW - Amyloid KW - 0 KW - Antimicrobial Cationic Peptides KW - Chlorides KW - Ion Channels KW - Protein Subunits KW - protegrin-1 KW - Index Medicus KW - Permeability KW - Protein Structure, Secondary KW - Amino Acid Motifs KW - Models, Molecular KW - Antimicrobial Cationic Peptides -- metabolism KW - Cell Death KW - Antimicrobial Cationic Peptides -- chemistry KW - Chlorides -- metabolism KW - Alzheimer Disease -- metabolism KW - Molecular Weight KW - Ion Transport KW - Alzheimer Disease -- pathology KW - Ion Channels -- chemistry KW - Ion Channels -- toxicity KW - Amyloid -- chemistry KW - Protein Folding KW - Protein Subunits -- toxicity KW - Protein Subunits -- metabolism KW - Protein Subunits -- chemistry KW - Amyloid -- metabolism KW - Ion Channels -- metabolism KW - Amyloid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734162581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+journal&rft.atitle=Misfolded+amyloid+ion+channels+present+mobile+beta-sheet+subunits+in+contrast+to+conventional+ion+channels.&rft.au=Jang%2C+Hyunbum%3BArce%2C+Fernando+Teran%3BCapone%2C+Ricardo%3BRamachandran%2C+Srinivasan%3BLal%2C+Ratnesh%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2009-12-02&rft.volume=97&rft.issue=11&rft.spage=3029&rft.isbn=&rft.btitle=&rft.title=Biophysical+journal&rft.issn=1542-0086&rft_id=info:doi/10.1016%2Fj.bpj.2009.09.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-05 N1 - Date created - 2009-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18119-24 [17108084] Biophys J. 1998 Apr;74(4):1622-39 [9545028] Biophys J. 2007 Sep 15;93(6):1938-49 [17526580] Biophys J. 2007 Nov 1;93(9):3046-57 [17675353] Trends Biochem Sci. 2008 Feb;33(2):91-100 [18182298] J Phys Chem B. 2008 Jun 5;112(22):6856-65 [18457440] J Biol Chem. 2008 Oct 31;283(44):29615-9 [18650430] Biophys J. 2008 Nov 15;95(10):4631-42 [18708452] Biophys J. 2008 Nov 15;95(10):4879-89 [18723589] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] J Neurosci Res. 2000 May 15;60(4):490-4 [10797551] J Biol Chem. 2000 May 12;275(19):14077-83 [10799482] FASEB J. 2000 Jun;14(9):1244-54 [10834946] Amyloid. 2000 Sep;7(3):194-9 [11019860] Brain Res Bull. 2000 Nov 1;53(4):389-97 [11136994] Amyloid. 2001 Jun;8(2):94-100 [11409039] Cell Mol Neurobiol. 2001 Jun;21(3):255-84 [11569537] FASEB J. 2001 Nov;15(13):2433-44 [11689468] J Biol Chem. 1998 May 29;273(22):13379-82 [9593665] J Neurosci Res. 1999 Aug 15;57(4):458-66 [10440895] Biochemistry. 1999 Aug 24;38(34):11189-96 [10460176] J Biol Chem. 2004 Nov 5;279(45):46363-6 [15385542] Science. 2005 Jan 7;307(5706):42-3; 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5593575 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Viboud, C AU - Pitzer, V AU - Simonsen, L AU - Parashar, U AU - Miller, M AU - Grenfell, B Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - USA KW - Infection KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42241734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=Comparative+spatial+dynamics+of+acute+viral+infections+in+the+USA&rft.au=Viboud%2C+C%3BPitzer%2C+V%3BSimonsen%2C+L%3BParashar%2C+U%3BMiller%2C+M%3BGrenfell%2C+B&rft.aulast=Viboud&rft.aufirst=C&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The shifting epidemiological landscape of influenza T2 - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AN - 42238621; 5593568 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Bansal, S AU - Pourbohloul, B AU - Meyers, L Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - Influenza KW - Landscape KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42238621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=The+shifting+epidemiological+landscape+of+influenza&rft.au=Bansal%2C+S%3BPourbohloul%2C+B%3BMeyers%2C+L&rft.aulast=Bansal&rft.aufirst=S&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The impact of vaccination on the dynamics of rotavirus epidemics in the USA T2 - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AN - 42238102; 5593521 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Pitzer, V AU - Viboud, C AU - Simonsen, L AU - Miller, M AU - Parashar, U AU - Grenfell, B Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - USA KW - Vaccination KW - Epidemics KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42238102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=The+impact+of+vaccination+on+the+dynamics+of+rotavirus+epidemics+in+the+USA&rft.au=Pitzer%2C+V%3BViboud%2C+C%3BSimonsen%2C+L%3BMiller%2C+M%3BParashar%2C+U%3BGrenfell%2C+B&rft.aulast=Pitzer&rft.aufirst=V&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccination strategies to mitigate pandemic influenza: Mexico as a case study T2 - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AN - 42237980; 5593567 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Chowell, G AU - Viboud, C AU - Wang, X AU - Miller, M Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - Mexico KW - Case studies KW - Influenza KW - Vaccination KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=Vaccination+strategies+to+mitigate+pandemic+influenza%3A+Mexico+as+a+case+study&rft.au=Chowell%2C+G%3BViboud%2C+C%3BWang%2C+X%3BMiller%2C+M&rft.aulast=Chowell&rft.aufirst=G&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The 1918-1920 influenza pandemic in Mexico: Age-specific mortality patterns and estimates of transmissibility T2 - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AN - 42237798; 5593542 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Chowell, G AU - Simonsen, L AU - Viboud, C AU - Miller, M AU - Acuna-Soto, R Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - Mexico KW - Mortality patterns KW - Influenza KW - Mortality KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=The+1918-1920+influenza+pandemic+in+Mexico%3A+Age-specific+mortality+patterns+and+estimates+of+transmissibility&rft.au=Chowell%2C+G%3BSimonsen%2C+L%3BViboud%2C+C%3BMiller%2C+M%3BAcuna-Soto%2C+R&rft.aulast=Chowell&rft.aufirst=G&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimating influenza hospitalization burden and the impact of antigenic variation T2 - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AN - 42237723; 5593531 JF - Second International Conference on Infectious Diseases Dynamics (EPIDEMICS2) AU - Ringholz, C AU - Thompson, W AU - Shay, D AU - Zhou, H AU - Cheng, P AU - Steiner, C AU - Smith, D AU - Russel, C AU - Miller, M AU - Simonsen, L AU - Viboud, C Y1 - 2009/12/02/ PY - 2009 DA - 2009 Dec 02 KW - Influenza KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.atitle=Estimating+influenza+hospitalization+burden+and+the+impact+of+antigenic+variation&rft.au=Ringholz%2C+C%3BThompson%2C+W%3BShay%2C+D%3BZhou%2C+H%3BCheng%2C+P%3BSteiner%2C+C%3BSmith%2C+D%3BRussel%2C+C%3BMiller%2C+M%3BSimonsen%2C+L%3BViboud%2C+C&rft.aulast=Ringholz&rft.aufirst=C&rft.date=2009-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Infectious+Diseases+Dynamics+%28EPIDEMICS2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.epidemics.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - High spatial and temporal resolution cardiac cine MRI from retrospective reconstruction of data acquired in real time using motion correction and resorting AN - 888097594; 15035190 AB - Cine MRI is used for assessing cardiac function and flow and is typically based on a breath-held, segmented data acquisition. Breath holding is particularly difficult for patients with congestive heart failure or in pediatric cases. Real-time imaging may be used without breath holding or ECG triggering. However, despite the use of rapid imaging sequences and accelerated parallel imaging, real-time imaging typically has compromised spatial and temporal resolution compared with gated, segmented breath-held studies. A new method is proposed that produces a cardiac cine across the full cycle, with both high spatial and temporal resolution from a retrospective reconstruction of data acquired over multiple heartbeats during free breathing. The proposed method was compared with conventional cine images in 10 subjects. The resultant image quality for the proposed method (4.2 +/- 0.4) without breath holding or gating was comparable to the conventional cine (4.4 +/- 0.5) on a five-point scale (P = n.s.). Motion-corrected averaging of real-time acquired cardiac images provides a means of attaining high-quality cine images with many of the benefits of real-time imaging, such as free-breathing acquisition and tolerance to arrhythmias. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Chefd'hotel, Christophe AU - Lorenz, Christine H AU - Mancini, Christine AU - Arai, Andrew E AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1557 EP - 1564 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 62 IS - 6 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888097594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=High+spatial+and+temporal+resolution+cardiac+cine+MRI+from+retrospective+reconstruction+of+data+acquired+in+real+time+using+motion+correction+and+resorting&rft.au=Kellman%2C+Peter%3BChefd%27hotel%2C+Christophe%3BLorenz%2C+Christine+H%3BMancini%2C+Christine%3BArai%2C+Andrew+E%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-12-01&rft.volume=62&rft.issue=6&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22153 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22153/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/mrm.22153 ER - TY - JOUR T1 - Magnetic susceptibility mapping of brain tissue in vivo using MRI phase data AN - 888097573; 15035186 AB - Phase images in susceptibility-weighted MRI of brain provide excellent contrast. However, the phase is affected by tissue geometry and orientation relative to the main magnetic field (B0), and phase changes extend beyond areas of altered susceptibility. Magnetic susceptibility, on the other hand, is an intrinsic tissue property, closely reflecting tissue composition. Therefore, recently developed inverse Fourier-based methods were applied to calculate susceptibility maps from high-resolution phase images acquired at a single orientation at 7 T in the human brain (in vivo and fixed) and at 11.7 T in fixed marmoset brain. In susceptibility images, the contrast of cortical layers was more consistent than in phase images and was independent of the structures' orientation relative to B0. The contrast of iron-rich deep-brain structures (red nucleus and substantia nigra) in susceptibility images agreed more closely with iron-dominated R images than the phase image contrast, which extended outside the structures. The mean susceptibility in these regions was significantly correlated with their estimated iron content. Susceptibility maps calculated using this method overcome the orientation-dependence and non-locality of phase image contrast and seem to reflect underlying tissue composition. Susceptibility images should be easier to interpret than phase images and could improve our understanding of the sources of susceptibility contrast. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Shmueli, Karin AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Li, Tie-Qiang AU - Dodd, Stephen J AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, shmuelik@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1510 EP - 1522 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 62 IS - 6 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - Brain mapping KW - Cortex KW - Data processing KW - Gene mapping KW - Iron KW - Magnetic fields KW - Magnetic resonance imaging KW - Magnetic susceptibility KW - N.M.R. KW - Red nucleus KW - Substantia nigra KW - Callithrix KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888097573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Magnetic+susceptibility+mapping+of+brain+tissue+in+vivo+using+MRI+phase+data&rft.au=Shmueli%2C+Karin%3Bde+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BLi%2C+Tie-Qiang%3BDodd%2C+Stephen+J%3BDuyn%2C+Jeff+H&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2009-12-01&rft.volume=62&rft.issue=6&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22135 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22135/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Substantia nigra; Magnetic fields; Brain mapping; Cortex; Red nucleus; Data processing; Magnetic resonance imaging; Brain; Magnetic susceptibility; N.M.R.; Iron; Gene mapping; Callithrix DO - http://dx.doi.org/10.1002/mrm.22135 ER - TY - JOUR T1 - Hypothesis: neoplasms in myotonic dystrophy. AN - 861203736; 19642006 AB - Tumorigenesis is a multi-step process due to an accumulation of genetic mutations in multiple genes in diverse pathways which ultimately lead to loss of control over cell growth. It is well known that inheritance of rare germline mutations in genes involved in tumorigenesis pathways confer high lifetime risk of neoplasia in affected individuals. Furthermore, a substantial number of multiple malformation syndromes include cancer susceptibility in their phenotype. Studies of the mechanisms underlying these inherited syndromes have added to the understanding of both normal development and the pathophysiology of carcinogenesis. Myotonic dystrophy (DM) represents a group of autosomal dominant, multisystemic diseases that share the clinical features of myotonia, muscle weakness, and early-onset cataracts. Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) result from unstable nucleotide repeat expansions in their respective genes. There have been multiple reports of tumors in individuals with DM, most commonly benign calcifying cutaneous tumors known as pilomatricomas. We provide a summary of the tumors reported in DM and a hypothesis for a possible mechanism of tumorigenesis. We hope to stimulate further study into the potential role of DM genes in tumorigenesis, and help define DM pathogenesis, and facilitate developing novel treatment modalities. JF - Cancer causes & control : CCC AU - Mueller, Christine M AU - Hilbert, James E AU - Martens, William AU - Thornton, Charles A AU - Moxley, Richard T AU - Greene, Mark H AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, EPS 7101, Rockville, MD 20852-7231, USA. muellerc@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 2009 EP - 2020 VL - 20 IS - 10 KW - Index Medicus KW - Concept Formation KW - Disease Susceptibility KW - Risk Factors KW - Humans KW - Models, Biological KW - Myotonic Dystrophy -- epidemiology KW - Neoplasms -- complications KW - Myotonic Dystrophy -- complications KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861203736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Hypothesis%3A+neoplasms+in+myotonic+dystrophy.&rft.au=Mueller%2C+Christine+M%3BHilbert%2C+James+E%3BMartens%2C+William%3BThornton%2C+Charles+A%3BMoxley%2C+Richard+T%3BGreene%2C+Mark+H&rft.aulast=Mueller&rft.aufirst=Christine&rft.date=2009-12-01&rft.volume=29&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Physical+and+Occupational+Therapy+in+Pediatrics&rft.issn=01942638&rft_id=info:doi/10.1080%2F01942630903028408 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-21 N1 - Date created - 2011-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Hematol. 2005 Mar;84(3):192-3 [15042318] Am J Hum Genet. 2005 Apr;76(4):572-80 [15706485] Cancer Res. 2005 May 15;65(10):3980-5 [15899785] Hum Mol Genet. 2005 Jun 1;14(11):1539-47 [15843400] Muscle Nerve. 2005 Jul;32(1):1-18 [15770660] Rev Clin Esp. 1981 Mar 31;160(6):405-7 [7255807] J Neurol Neurosurg Psychiatry. 1981 Sep;44(9):852-3 [7310430] Hautarzt. 1982 May;33(5):271-5 [7096091] Acta Neurol (Napoli). 1982 Apr;4(2):79-91 [7113778] Dermatologica. 1985;170(3):128-32 [3979639] Hautarzt. 1986 Apr;37(4):226-9 [3700107] Arch Intern Med. 1987 Apr;147(4):777-8 [3827466] J Am Acad Dermatol. 1987 Apr;16(4):887-8 [3571556] Presse Med. 1987 Sep 12;16(29):1434 [2958804] Arch Intern Med. 1988 Jan;148(1):237, 241 [3337600] Am J Med Genet. 1998 Apr 28;77(1):81-2 [9557902] Am J Med Genet. 1998 Jul 7;78(3):267-70 [9677064] J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):191-5 [9704827] Surg Neurol. 1998 Nov;50(5):446-8 [9842869] Cell. 1998 Nov 25;95(5):605-14 [9845363] Int J Dermatol. 1992 May;31(5):348-50 [1587666] Br J Dermatol. 1992 Aug;127(2):194-5 [1390157] Cutis. 1992 Oct;50(4):290-2 [1424796] Dig Dis Sci. 1992 Dec;37(12):1922-5 [1473442] Ann Dermatol Venereol. 1992;119(11):899-900 [1301716] Curr Opin Neurol. 1994 Oct;7(5):427-34 [7804464] Am J Hum Genet. 1995 Jan;56(1):114-22 [7825566] J Int Med Res. 1994 Sep-Oct;22(5):296-8 [7867876] Genes Dev. 1995 Mar 1;9(5):534-46 [7698644] Am J Med Genet. 1995 Mar 13;56(1):112-5 [7747773] Rev Clin Esp. 1995 Jul;195(7):516-7 [7667532] J Clin Endocrinol Metab. 1995 Dec;80(12):3715-23 [8530624] Clin Exp Dermatol. 1995 Sep;20(5):423-4 [8593723] Nat Genet. 1996 Jul;13(3):316-24 [8673131] Nat Genet. 1996 Jul;13(3):325-35 [8673132] Am J Med Sci. 1996 Jun;311(6):296-8 [8659558] Pediatr Dermatol. 1995 Dec;12(4):331-5 [8747580] J Fr Ophtalmol. 1996;19(6-7):464-6 [8881409] Int J Dermatol. 1996 Oct;35(10):732-3 [8891827] Rev Neurol. 1997 Feb;25(138):306-7 [9147767] Muscle Nerve. 1997 May;20(5):622-4 [9140374] Intern Med. 1999 Jun;38(6):504-6 [10411358] Br J Plast Surg. 1999 Mar;52(2):143-5 [10434894] Muscle Nerve. 1999 Sep;22(9):1271-4 [10454725] N Z Med J. 1958 Oct;57(321):482-6 [13600695] Novartis Found Symp. 2004;262:247-60; discussion 260-68 [15562834] Mol Cell Biol. 2004 Dec;24(24):10689-702 [15572674] Masui. 2004 Nov;53(11):1290-2 [15587184] J Cutan Pathol. 2005 Feb;32(2):148-57 [15606674] Rinsho Shinkeigaku. 1998 Aug;38(8):736-8 [9916519] Nat Genet. 1999 Apr;21(4):410-3 [10192393] Riv Neurol. 1988 May-Jun;58(3):124-6 [3175462] J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1578-80 [2906090] Med Cutan Ibero Lat Am. 1989;17(6):395-8 [2699641] Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;59(1):11-6 [1974093] Cell. 1991 Aug 9;66(3):589-600 [1651174] J Dermatol Surg Oncol. 1991 Sep;17(9):728-30 [1890244] Br J Dermatol. 1999 Nov;141(5):941-2 [10583193] Neurology. 2000 Mar 28;54(6):1218-21 [10746587] J Cell Biol. 2000 Apr 17;149(2):249-54 [10769018] Muscle Nerve. 2000 May;23(5):804-6 [10797405] Genes Dev. 2000 Aug 1;14(15):1837-51 [10921899] Gastroenterology. 2000 Sep;119(3):837-53 [10982778] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12613-8 [11050151] J Laryngol Otol. 2000 Dec;114(12):985-7 [11177377] Hautarzt. 2001 Mar;52(3):244-6 [11284072] Pathol Int. 2001 Jul;51(7):543-8 [11472567] Jpn J Thorac Cardiovasc Surg. 2001 Jul;49(7):457-60 [11517583] Am J Dermatopathol. 2001 Dec;23(6):521-4 [11801793] Eur J Dermatol. 2002 May-Jun;12(3):293-4 [11978577] Intern Med. 2002 Apr;41(4):312-8 [11993794] Chest. 2002 Jun;121(6):2061-3 [12065378] J Med Genet. 2002 Jul;39(7):496-501 [12114483] Int J Cancer. 2002 Aug 10;100(5):549-56 [12124804] Curr Biol. 2002 Jul 23;12(14):R499-R501 [12176352] Neurology. 2003 Feb 25;60(4):657-64 [12601109] Br J Dermatol. 2003 May;148(5):964-70 [12786827] Clin Exp Obstet Gynecol. 2003;30(2-3):147-50 [12854863] Am J Dermatopathol. 1992 Apr;14(2):87-94 [1566981] Biochem Soc Trans. 2005 Aug;33(Pt 4):672-5 [16042571] Hum Genet. 2005 Sep;117(5):485-93 [16021471] Int J Cancer. 2006 Feb 1;118(3):643-8 [16108035] Int J Dermatol. 2006 Jan;45(1):87-8 [16426388] Cytogenet Genome Res. 2003;100(1-4):7-24 [14526162] Cytogenet Genome Res. 2003;100(1-4):25-55 [14526163] Masui. 2003 Sep;52(9):993-5 [14531262] Trends Mol Med. 2003 Nov;9(11):455-7 [14604819] Biochem Biophys Res Commun. 2003 Dec 12;312(2):380-7 [14637149] JBR-BTR. 2003 Sep-Oct;86(5):268-71 [14651081] Science. 2003 Dec 12;302(5652):1978-80 [14671308] J Am Acad Dermatol. 2004 Feb;50(2 Suppl):S1-3 [14726854] EMBO J. 2004 Jan 28;23(2):406-17 [14726956] Am J Pathol. 2004 May;164(5):1739-49 [15111320] Oncogene. 2004 May 24;23(24):4225-31 [15156177] Br J Dermatol. 2004 Jul;151(1):157-64 [15270885] EMBO J. 2004 Aug 4;23(15):3103-12 [15257297] Acta Genet Stat Med. 1966;16(1):103-12 [4955838] Acta Derm Venereol. 1965;45(5):387-90 [4162862] JAMA. 1969 Apr 28;208(4):696 [5818819] Arch Dermatol. 1972 Jul;106(1):41-4 [5039107] J Neurol Sci. 1973 Sep;20(1):1-6 [4744509] Arch Dermatol. 1973 Oct;108(4):532-4 [4745286] Birth Defects Orig Artic Ser. 1971 Jun;7(8):343-5 [5173307] Acta Neurol Scand. 1978 Mar;57(3):275-8 [208345] Arch Dermatol. 1978 Sep;114(9):1363-5 [686751] Anaesthesia. 1980 May;35(5):492-5 [7396152] J Neurol Neurosurg Psychiatry. 1981 Feb;44(2):173-5 [7217976] J Med Genet. 1981 Apr;18(2):134-8 [6787200] Dermatologica. 1981;162(3):197-202 [7250464] Neuromuscul Disord. 1997 May;7(3):152-5 [9185177] J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):268-9 [9270517] An Med Interna. 1997 Aug;14(8):409-11 [9376481] Cancer Res. 1998 Mar 1;58(5):1021-6 [9500465] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9395-y ER - TY - JOUR T1 - Brief Report: Further Evidence for Inner Speech Deficits in Autism Spectrum Disorders AN - 85706427; 201005933 AB - Recent research indicates that individuals with autism do not effectively use inner speech during the completion of cognitive tasks. We used Articulatory Suppression (AS) to interfere with inner speech during completion of alternate items from the Tower of London (TOL). AS detrimentally affected TOL performance among typically developing (TD) adolescents (n=25), but did not significantly diminish performance among adolescents with high functioning (IQ>80) autism spectrum disorders (n=28). Moreover, the TD group's TOL performance under AS was indistinguishable from the autism group's impaired baseline TOL performance. These findings suggest that diminished inner speech usage among individuals with high functioning autism spectrum disorders (relative to TD controls) may contribute to executive dysfunction associated with these disorders. Adapted from the source document JF - Journal of Autism and Developmental Disorders AU - Wallace, Gregory L AU - Silvers, Jennifer A AU - Martin, Alex AU - Kenworthy, Lauren E AD - Laboratory Brain Cognition, National Instit Mental Health, Bethesda, MD gregwallace@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1735 EP - 1739 VL - 39 IS - 12 SN - 0162-3257, 0162-3257 KW - Cognitive Processes (12950) KW - Autism (06800) KW - Problem Solving (67850) KW - Inner Speech (36300) KW - Executive Function (23470) KW - Asperger Syndrome (05120) KW - article KW - 6610: mental retardation and disorders; mental disorders/mental retardation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85706427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Brief+Report%3A+Further+Evidence+for+Inner+Speech+Deficits+in+Autism+Spectrum+Disorders&rft.au=Wallace%2C+Gregory+L%3BSilvers%2C+Jennifer+A%3BMartin%2C+Alex%3BKenworthy%2C+Lauren+E&rft.aulast=Wallace&rft.aufirst=Gregory&rft.date=2009-12-01&rft.volume=39&rft.issue=12&rft.spage=1735&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Inner Speech (36300); Autism (06800); Cognitive Processes (12950); Executive Function (23470); Problem Solving (67850); Asperger Syndrome (05120) ER - TY - JOUR T1 - Performance measures of alcohol-induced impairment: towards a practical ignition-interlock system for motor vehicles. AN - 85334500; pmid-20178284 AB - Performance-based alcohol screening devices may help reduce road traffic accidents, but there is a shortage of easy-to-use performance tests available. To address this issue, four recently developed rapid, computerized, easily implementable performance tests, Spiral for iPhone and Spiral for Mac (psychomotor tests), and the Modified Mental Rotation and Catch the Rabbit tests (cognitive tests), were assessed, testing participants at predrink baseline and then during three progressive amounts of alcohol intake. Analyses showed all tests were performed statistically significantly less accurately at 0.11% blood alcohol concentrations (BACs) than at 0.00% BAC, as were all tests except Spiral for iPhone at 0.06% BAC. These results indicate the suitability of all of these tests for measuring alcohol-induced impairment, and some potential for use as a practical performance-based alcohol screening device. JF - Perceptual and motor skills AU - Matsumura, Kenta AU - Yamakoshi, Takehiro AU - Ida, Takayuki AD - Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo187-8553, Japan. kenta@ncnp.go.jp Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 841 EP - 850 VL - 109 IS - 3 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - *Accidents, Traffic: prevention & control KW - Adult KW - Alcohol Drinking: adverse effects KW - Alcohol Drinking: psychology KW - *Alcoholic Intoxication: diagnosis KW - *Alcoholic Intoxication: psychology KW - *Attention: drug effects KW - *Automobiles KW - *Diagnosis, Computer-Assisted: instrumentation KW - Discrimination (Psychology) KW - Dose-Response Relationship, Drug KW - Equipment Design KW - Humans KW - Male KW - *Mass Screening: instrumentation KW - Microcomputers KW - *Neuropsychological Tests: statistics & numerical data KW - Orientation KW - Pattern Recognition, Visual KW - Psychometrics: statistics & numerical data KW - *Psychomotor Performance: drug effects KW - *Reaction Time: drug effects KW - Reproducibility of Results KW - Software KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85334500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Performance+measures+of+alcohol-induced+impairment%3A+towards+a+practical+ignition-interlock+system+for+motor+vehicles.&rft.au=Matsumura%2C+Kenta%3BYamakoshi%2C+Takehiro%3BIda%2C+Takayuki&rft.aulast=Matsumura&rft.aufirst=Kenta&rft.date=2009-12-01&rft.volume=109&rft.issue=3&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Inhibitory control in anxious and healthy adolescents is modulated by incentive and incidental affective stimuli AN - 839572047; 201101693 AB - Background: Anxiety disorders are characterized by elevated, sustained responses to threat, that manifest as threat attention biases. Recent evidence also suggests exaggerated responses to incentives. How these characteristics influence cognitive control is under debate and is the focus of the present study. Methods: Twenty-five healthy adolescents and 25 adolescents meeting DSM-IV diagnostic criteria for an anxiety disorder were compared on a task of response inhibition. Inhibitory control was assayed with an antisaccade task that included both incentive (monetary reward) and incidental emotion (facial expression) cues presented prior to the execution of inhibitory behavior. Results: Inhibitory control was enhanced following exposure to threat cues (fear faces) only in adolescent patients, and following exposure to positive cues (happy faces) only in healthy adolescents. Results also revealed a robust performance improvement associated with monetary incentives. This incentive effect did not differ by group. No interaction between incentives and emotional cues was detected. Conclusions: These findings suggest that biased processing of threat in anxious adolescents affects inhibitory control, perhaps by raising arousal prior to behavioral performance. The absence of normalization of performance in anxious adolescents following exposure to positive emotional cues is a novel finding and will require additional exploration. Future studies will need to more specifically examine how perturbations in positive emotion processes contribute to the symptomatology and the pathogenesis of anxiety disorders. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Hardin, Michael G AU - Mandell, Darcy AU - Mueller, Sven C AU - Dahl, Ronald E AU - Pine, Daniel S AU - Ernst, Monique AD - Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH-DHHS, USA hardinm@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1550 EP - 1558 PB - Blackwell Publishing, Oxford UK VL - 50 IS - 12 SN - 0021-9630, 0021-9630 KW - Emotion motivation cognitive control affective context anxiety disorders facial expressions KW - Anxiety disorders KW - Facial expressions KW - Inhibitory processes KW - Cues KW - Incentives KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839572047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Inhibitory+control+in+anxious+and+healthy+adolescents+is+modulated+by+incentive+and+incidental+affective+stimuli&rft.au=Hardin%2C+Michael+G%3BMandell%2C+Darcy%3BMueller%2C+Sven+C%3BDahl%2C+Ronald+E%3BPine%2C+Daniel+S%3BErnst%2C+Monique&rft.aulast=Hardin&rft.aufirst=Michael&rft.date=2009-12-01&rft.volume=50&rft.issue=12&rft.spage=1550&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2009.02121.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Adolescents; Incentives; Anxiety disorders; Inhibitory processes; Cues; Facial expressions DO - http://dx.doi.org/10.1111/j.1469-7610.2009.02121.x ER - TY - JOUR T1 - Quantitative measurement of aging using image texture entropy AN - 818836060; 13761505 AB - Motivation: A key element in understanding the aging of Caenorhabditis elegans is objective quantification of the morphological differences between younger and older animals. Here we propose to use the image texture entropy as an objective measurement that reflects the structural deterioration of the C.elegans muscle tissues during aging.Results: The texture entropy and directionality of the muscle microscopy images were measured using 50 animals on Days 0, 2, 4, 6, 8, 10 and 12 of adulthood. Results show that the entropy of the C.elegans pharynx tissues increases as the animal ages, but a sharper increase was measured between Days 2 and 4, and between Days 8 and 10. These results are in agreement with gene expression findings, and support the contention that the process of C.elegans aging has several distinct stages. This can indicate that C.elegans aging is driven by developmental pathways, rather than stochastic accumulation of damage. JF - Bioinformatics AU - Shamir, Lior AU - Wolkow, Catherine A AU - Goldberg, Ilya G AD - Laboratory of Genetics, National Institute on Aging/NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA Y1 - 2009/12/01/ PY - 2009 DA - 2009 Dec 01 SP - 3060 EP - 3063 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 23 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Pharynx KW - Caenorhabditis elegans KW - Aging KW - Microscopy KW - Muscles KW - Bioinformatics KW - Stochasticity KW - Entropy KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818836060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Quantitative+measurement+of+aging+using+image+texture+entropy&rft.au=Shamir%2C+Lior%3BWolkow%2C+Catherine+A%3BGoldberg%2C+Ilya+G&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2009-12-01&rft.volume=25&rft.issue=23&rft.spage=3060&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp571 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Gene expression; Pharynx; Data processing; Microscopy; Aging; Muscles; Bioinformatics; Stochasticity; Internet; Entropy; Caenorhabditis elegans DO - http://dx.doi.org/10.1093/bioinformatics/btp571 ER - TY - JOUR T1 - Disputing the myth of the sexual dysfunction of circumcised women: an interview with Fuambai Ahmadu by Richard Shweder AN - 816380394; 4136732 AB - This interview on the subject of female genital cutting serves to contextualize a submission by Carlos D. Londoño Sulkin, who describes the changes of perception he and other members of the audience experienced after a lecture by Fuambai Ahmadu on this subject at the University of Regina on 19 March 2009. The title of Ahmadu's talk was `Disputing the myth of the sexual dysfunction of circumcised women'. In order to make sense of Londoño Sulkin's reactions to her account, Fuambai Ahmadu was invited to set out her case, which she does in the form of a question-and-answer session with Richard Shweder. Reprinted by permission of the Royal Anthropological Institute of Great Britain and Ireland JF - Anthropology today AU - Ahmadu, Fuambai S AU - Shweder, Richard A AD - National Institutes of Health ; University of Chicago Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 14 EP - 16 VL - 25 IS - 6 SN - 0268-540X, 0268-540X KW - Anthropology KW - Circumcision KW - Females KW - Genital mutilation KW - Interviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/816380394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anthropology+today&rft.atitle=Disputing+the+myth+of+the+sexual+dysfunction+of+circumcised+women%3A+an+interview+with+Fuambai+Ahmadu+by+Richard+Shweder&rft.au=Ahmadu%2C+Fuambai+S%3BShweder%2C+Richard+A&rft.aulast=Ahmadu&rft.aufirst=Fuambai&rft.date=2009-12-01&rft.volume=25&rft.issue=6&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Anthropology+today&rft.issn=0268540X&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6832 10919; 5461 1681; 4865 11538; 2269 1681 11043 11045 3237 12867 ER - TY - JOUR T1 - Climate Change and the Geographic Distribution of Infectious Diseases AN - 754569038; 13418249 AB - Our ability to predict the effects of climate change on the spread of infectious diseases is in its infancy. Numerous, and in some cases conflicting, predictions have been developed, principally based on models of biological processes or mapping of current and historical disease statistics. Current debates on whether climate change, relative to socioeconomic determinants, will be a major influence on human disease distributions are useful to help identify research needs but are probably artificially polarized. We have at least identified many of the critical geophysical constraints, transport opportunities, biotic requirements for some disease systems, and some of the socioeconomic factors that govern the process of migration and establishment of parasites and pathogens. Furthermore, we are beginning to develop a mechanistic understanding of many of these variables at specific sites. Better predictive understanding will emerge in the coming years from analyses regarding how these variables interact with each other. JF - EcoHealth AU - Rosenthal, Joshua AD - Division of International Training and Research, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA, joshua_rosenthal@nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 489 EP - 495 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 6 IS - 4 SN - 1612-9202, 1612-9202 KW - Ecology Abstracts; Sustainability Science Abstracts KW - migration KW - Historical account KW - Parasites KW - Geographical distribution KW - Statistics KW - Climate change KW - Climatic changes KW - Socioeconomics KW - Pathogens KW - Migration KW - Models KW - Socio-economic aspects KW - Infectious diseases KW - Mapping KW - Geophysics KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754569038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EcoHealth&rft.atitle=Climate+Change+and+the+Geographic+Distribution+of+Infectious+Diseases&rft.au=Rosenthal%2C+Joshua&rft.aulast=Rosenthal&rft.aufirst=Joshua&rft.date=2009-12-01&rft.volume=6&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=EcoHealth&rft.issn=16129202&rft_id=info:doi/10.1007%2Fs10393-010-0314-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Parasites; Socio-economic aspects; Geographical distribution; Statistics; Infectious diseases; Climatic changes; Pathogens; Migration; Models; Historical account; migration; Climate change; Socioeconomics; Geophysics; Mapping DO - http://dx.doi.org/10.1007/s10393-010-0314-1 ER - TY - JOUR T1 - Growth of Lactic Acid Bacteria during the Fermentation of Laminaria japonica Polysaccharide-hydrolysates Solution AN - 754532634; 13232882 AB - The purpose of this study is to develop the enzyme-digested hot water polysaccharide extract of Laminaria (Lam.) japonica fermented by lactic acid bacteria (LAB). A Lam. japonica oligosaccharide solution (L-Lam) was prepared from Lam digested in 5 units/ml cellulase and 5 units/ml agarases (MA103-agarases and MAEF08-agarases) at 40C for 12 h, and then obtained a Lam. japonica oligosaccharide solution (L-Lam). Two percent of (I) Lam, (II) L-Lam, (III) L-Lam plus 0.5% yeast extract, or (IV) L-Lam plus 0.5% peptone were fermented individually with the following LAB starter groups: (A) Lactobacillus (Lb.) rhamnosus BCRC14068 and Enterococcus (Ent.) faecalis BCRC13076, (B) Lb. plantarum BCRC10069 and Lb. plantarum BCRC12250, or (C) Lb. plantarum BCRC10069 and Lactococcus (Lc.) lactis BCRC12315. The three groups of LAB starters used 3% or 5% inoculums, and were incubated at 37C to obtain Lam or L-Lam LAB fermented solutions. This resulted in an L-Lam plus 0.5% yeast extract fermented LAB starter group, BCRC10069 and BCRC12250, which could reach the end point of fermentation (pH < 4.6) in 4 h. Its titratable acidity value and lactic acid bacteria count were the highest among the Lam or L-Lam LAB fermented solutions. JF - Journal of the Fisheries Society of Taiwan AU - Shao-Chi, W AU - Shan-Wen, S AU - Kuo-Chang, Z AU - Chorng-Liang, P AD - Department of Food Science and Technology, Tung-Fang Institute of Technology, 110 Tung-Fang Road, Hu-Nei Hsiang, Kaohsiung, Taiwan 829, ROC, agarase@msn.com Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 251 EP - 263 VL - 36 IS - 4 SN - 0379-4180, 0379-4180 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Yeasts KW - Fermentation KW - Polysaccharides KW - Cellulase KW - Lactobacillus KW - Laminaria japonica KW - peptone KW - Inoculum KW - Peptones KW - Acidity KW - pH effects KW - Marine KW - oligosaccharides KW - Lactate KW - Enzymes KW - Lactic acid bacteria KW - Agarase KW - Enterococcus KW - Laminaria KW - Lactococcus KW - Plant extracts KW - Q1 08201:General KW - A 01310:Products of Microorganisms KW - J 02320:Cell Biology KW - W 30945:Fermentation & Cell Culture KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754532634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Fisheries+Society+of+Taiwan&rft.atitle=Growth+of+Lactic+Acid+Bacteria+during+the+Fermentation+of+Laminaria+japonica+Polysaccharide-hydrolysates+Solution&rft.au=Shao-Chi%2C+W%3BShan-Wen%2C+S%3BKuo-Chang%2C+Z%3BChorng-Liang%2C+P&rft.aulast=Shao-Chi&rft.aufirst=W&rft.date=2009-12-01&rft.volume=36&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Fisheries+Society+of+Taiwan&rft.issn=03794180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Yeasts; Fermentation; Lactate; Enzymes; Peptones; Polysaccharides; Acidity; oligosaccharides; peptone; Inoculum; Lactic acid bacteria; Plant extracts; Agarase; pH effects; Cellulase; Lactobacillus; Laminaria japonica; Enterococcus; Laminaria; Lactococcus; Marine ER - TY - JOUR T1 - Marital conflict and adolescents' peer aggression: the mediating and moderating role of mother-child emotional reciprocity AN - 753840980; 3995152 JF - Family relations AU - Lindsey, Eric W AU - Chambers, Jessica Campbell AU - Frabutt, James M AU - Mackinnon-Lewis, Carol AD - National Institute on Drug Abuse, USA ; University of Notre Dame ; University of South Florida Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 593 EP - 606 VL - 58 IS - 5 SN - 0197-6664, 0197-6664 KW - Sociology KW - Anthropology KW - Emotions KW - Peer groups KW - Parent-child relations KW - Family relations KW - Mediation KW - Adolescents KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753840980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+relations&rft.atitle=Marital+conflict+and+adolescents%27+peer+aggression%3A+the+mediating+and+moderating+role+of+mother-child+emotional+reciprocity&rft.au=Lindsey%2C+Eric+W%3BChambers%2C+Jessica+Campbell%3BFrabutt%2C+James+M%3BMackinnon-Lewis%2C+Carol&rft.aulast=Lindsey&rft.aufirst=Eric&rft.date=2009-12-01&rft.volume=58&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Family+relations&rft.issn=01976664&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9347; 593; 7869 2703 2698; 4196; 9178 4777 6093 6823; 4777 6093; 4783 ER - TY - JOUR T1 - The Pivotal Role of Electron Microscopic Evaluation in Investigation of the Cardiotoxicity of bis(2-chloroethoxy)methane in Rats and Mice AN - 746198580; 12621284 AB - Electron microscopy and light microscopy have been used to evaluate the cardiotoxicity of bis(2-chloroethoxy)methane (CEM) in F344/N rats and B6C3F1 mice. Rats received vehicle control or CEM at 50 mg/kg/day, and mice, vehicle control or CEM at doses up to 100 mg/kg/day, by oral gavage for up to sixteen days. Cardiotoxicity in rats at 50 mg/kg consisted of myocardial degeneration, including myocardial inflammation, myofiber vacuolation, and/or myofiber necrosis. There was no light microscopic evidence for cardiotoxicity in mice even at doses twice that of rats, but cardiotoxic damage was seen after electron microscopic evaluations including mitochondrial disintegration and vacuolation. Mice with mitochondrial damage may be more susceptible to subsequent cardiotoxic events and have a reduced capacity to respond when energy demands increase. Oral treatment of rats with CEM caused cardiotoxic lesions similar to those reported after dermal administration (Dunnick, Johnson, et al. 2004). The F344/N rat is more sensitive than the B6C3F1 mouse to the cardiotoxic effects of CEM. JF - Toxicologic Pathology AU - Nyska, Abraham AU - Cunningham, Michael AU - Snell, Michael AU - Malarkey, David AU - Sutton, D AU - Dunnick, June AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 873 EP - 877 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Necrosis KW - Skin KW - Mitochondria KW - Degeneration KW - Electron microscopy KW - Inflammation KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746198580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=The+Pivotal+Role+of+Electron+Microscopic+Evaluation+in+Investigation+of+the+Cardiotoxicity+of+bis%282-chloroethoxy%29methane+in+Rats+and+Mice&rft.au=Nyska%2C+Abraham%3BCunningham%2C+Michael%3BSnell%2C+Michael%3BMalarkey%2C+David%3BSutton%2C+D%3BDunnick%2C+June&rft.aulast=Nyska&rft.aufirst=Abraham&rft.date=2009-12-01&rft.volume=37&rft.issue=7&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309347908 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Necrosis; Skin; Mitochondria; Degeneration; Electron microscopy; Inflammation DO - http://dx.doi.org/10.1177/0192623309347908 ER - TY - JOUR T1 - A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer AN - 746197248; 12621296 AB - Tumor response in the B6C3F1 mouse, F344 rat, and other animal models following exposure to various compounds provides evidence that people exposed to these or similar compounds may be at risk for developing cancer. Although tumors in rodents and humans are often morphologically similar, underlying mechanisms of tumorigenesis are often unknown and may be different between the species. Therefore, the relevance of an animal tumor response to human health would be better determined if the molecular pathogenesis were understood. The underlying molecular mechanisms leading to carcinogenesis are complex and involve multiple genetic and epigenetic events and other factors. To address the molecular pathogenesis of environmental carcinogens, the authors examine rodent tumors (e.g., lung, colon, mammary gland, skin, brain, mesothelioma) for alterations in cancer genes and epigenetic events that are associated with human cancer. National Toxicology Program (NTP) studies have identified several genetic alterations in chemically induced rodent neoplasms that are important in human cancer. Identification of such alterations in rodent models of chemical carcinogenesis caused by exposure to environmental contaminants, occupational chemicals, and other compounds lends further support that they are of potential human health risk. These studies also emphasize the importance of molecular evaluation of chemically induced rodent tumors for providing greater public health significance for NTP evaluated compounds. JF - Toxicologic Pathology AU - Hoenerhoff, Mark J AU - Hong, Hue Hua AU - Ton, Tai-Vu AU - Lahousse, Stephanie A AU - Sills, Robert C AD - National Institutes of Environmental Health Sciences, Research Triangle Park, NC, hoenerhm@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 835 EP - 848 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Molecular modelling KW - Skin KW - Mammary gland KW - Tumorigenesis KW - Brain KW - Animal models KW - Carcinogens KW - Cancer KW - Neoplasia KW - Public health KW - Colon KW - epigenetics KW - Reviews KW - Carcinogenesis KW - mesothelioma KW - Contaminants KW - Occupational exposure KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746197248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=A+Review+of+the+Molecular+Mechanisms+of+Chemically+Induced+Neoplasia+in+Rat+and+Mouse+Models+in+National+Toxicology+Program+Bioassays+and+Their+Relevance+to+Human+Cancer&rft.au=Hoenerhoff%2C+Mark+J%3BHong%2C+Hue+Hua%3BTon%2C+Tai-Vu%3BLahousse%2C+Stephanie+A%3BSills%2C+Robert+C&rft.aulast=Hoenerhoff&rft.aufirst=Mark&rft.date=2009-12-01&rft.volume=37&rft.issue=7&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309351726 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Skin; Mammary gland; Tumorigenesis; Animal models; Brain; Carcinogens; Neoplasia; Cancer; Public health; Colon; epigenetics; Reviews; Carcinogenesis; mesothelioma; Contaminants; Occupational exposure DO - http://dx.doi.org/10.1177/0192623309351726 ER - TY - JOUR T1 - Pharmacomimetics of Exercise: Novel Approaches for Hippocampally- Targeted Neuroprotective Agents AN - 745903737; 12690800 AB - Coordinated and constructive physical activity is correlated with the maintenance of cognitive function in humans. Voluntary running also enhances neuroplasticity in adult and aging rodents, but the molecular pathways underlying these effects are still being elucidated. Considering the multifactorial nature of the biochemical links between physical activity and neurophysiology, it is likely that there are many pharmacological mechanisms by which the beneficial actions of exercise can be effectively reproduced using chemical agents. Most studies to date have focused on brain-derived neurotrophic factor (BDNF) as a signaling target for the enhancement of neuronal function by exercise. The goal of the current review is to move beyond BDNF by exploring the diversity of molecular pathways regulated by physical activity in a variety of situations. We will discuss the availability and mechanism of action for several diverse physical activity pharmacomimetics. As physical activity enhances both neuroplasticity and cognition, understanding the molecular targets for these effects may lead to the development of potent new therapeutic interventions for age-related neurodegenerative conditions such as Alzheimer's disease. JF - Current Medicinal Chemistry AU - Stranahan, A M AU - Zhou, Y AU - Martin, B AU - Maudsley, S AD - National Institute on Aging, Biomedical Research Center, Suite 100, Room 5C228, 251 Bayview Boulevard, Baltimore MD 21224, USA. Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 4668 EP - 4678 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 16 IS - 35 SN - 0929-8673, 0929-8673 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Age KW - Multiculturalism KW - Hippocampus KW - Neuroprotective agents KW - Physical activity KW - Aging KW - Alzheimer's disease KW - Therapeutic applications KW - Plasticity KW - Cognition KW - Exercise biochemistry KW - Recruiting KW - Brain-derived neurotrophic factor KW - Running KW - Exercise KW - Maintenance KW - Neurophysiology KW - Physical training KW - Neurodegenerative diseases KW - Cognitive ability KW - Reviews KW - Running (effects) KW - Signal transduction KW - PE 090:Sports Medicine & Exercise Sport Science KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745903737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medicinal+Chemistry&rft.atitle=Pharmacomimetics+of+Exercise%3A+Novel+Approaches+for+Hippocampally-+Targeted+Neuroprotective+Agents&rft.au=Stranahan%2C+A+M%3BZhou%2C+Y%3BMartin%2C+B%3BMaudsley%2C+S&rft.aulast=Stranahan&rft.aufirst=A&rft.date=2009-12-01&rft.volume=16&rft.issue=35&rft.spage=4668&rft.isbn=&rft.btitle=&rft.title=Current+Medicinal+Chemistry&rft.issn=09298673&rft_id=info:doi/10.2174%2F092986709789878292 LA - English DB - Physical Education Index N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Multiculturalism; Exercise biochemistry; Alzheimer's disease; Running (effects); Recruiting; Exercise; Cognition; Neurophysiology; Maintenance; Brain-derived neurotrophic factor; Age; Hippocampus; Physical activity; Neuroprotective agents; Running; Aging; Therapeutic applications; Plasticity; Physical training; Neurodegenerative diseases; Cognitive ability; Reviews; Signal transduction DO - http://dx.doi.org/10.2174/092986709789878292 ER - TY - JOUR T1 - Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjogren's syndrome AN - 745729691; 12741893 AB - Objective Interleukin-12 (IL-12) is a pleiotropic cytokine that is elevated in the affected organs of patients with Sjogren's syndrome (SS). We have previously reported that overexpression of IL-12 in CBA mice leads to mononuclear infiltration of salivary and lacrimal glands, as well as to expansion of bronchial lymphoid tissue and decreased mucociliary clearance. Because xerostomia is one of the most important clinical features in SS patients, our main objective in the current study was to evaluate salivary gland function in IL-12-transgenic mice. Our secondary objective was to further characterize this animal model and to determine if the changes observed in these mice are representative of those observed in patients with SS overall. Methods Pilocarpine-stimulated salivary flow was used to address salivary gland function in a large group of IL-12-transgenic mice bred onto the autoimmune-prone SJL background. Furthermore, salivary glands were removed to assess the formation of infiltrates in the glands and gland morphology. Serum was also collected from these animals to investigate the formation of autoantibodies. Results Pilocarpine-stimulated salivary flow was significantly lower in IL-12-transgenic mice than in wild-type controls. Salivary glands from transgenic mice exhibited an increase in both the number and the size of lymphocytic foci, versus glands from age-matched controls. Furthermore, the acini in transgenic mice were fewer in number and larger in size compared with acini in controls. An age-dependent increase in anti-SSB/La antibodies was observed in IL-12-transgenic mice and was accompanied by an increase in antinuclear antibodies. Conclusion Our findings indicate that a number of conditions associated with SS are exhibited by IL-12-transgenic SJL mice and that this model might be useful in researching multiple aspects of the disease. JF - Arthritis & Rheumatism AU - Vosters, Jelle L AU - Landek-Salgado, Melissa A AU - Yin, Hongen AU - Swaim, William D AU - Kimura, Hiroaki AU - Tak, Paul P AU - Caturegli, Patrizio AU - Chiorini, John A AD - National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, pcat@jhmi.edu Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 3633 EP - 3641 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 60 IS - 12 SN - 0004-3591, 0004-3591 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Sjogren's syndrome KW - Interleukin 12 KW - Antinuclear antibodies KW - Autoantibodies KW - Autoimmune diseases KW - Animal models KW - Salivary gland KW - Transgenic mice KW - Lymphoid tissue KW - xerostomia KW - Lacrimal gland KW - W 30910:Imaging KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745729691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+%26+Rheumatism&rft.atitle=Interleukin-12+induces+salivary+gland+dysfunction+in+transgenic+mice%2C+providing+a+new+model+of+Sjogren%27s+syndrome&rft.au=Vosters%2C+Jelle+L%3BLandek-Salgado%2C+Melissa+A%3BYin%2C+Hongen%3BSwaim%2C+William+D%3BKimura%2C+Hiroaki%3BTak%2C+Paul+P%3BCaturegli%2C+Patrizio%3BChiorini%2C+John+A&rft.aulast=Vosters&rft.aufirst=Jelle&rft.date=2009-12-01&rft.volume=60&rft.issue=12&rft.spage=3633&rft.isbn=&rft.btitle=&rft.title=Arthritis+%26+Rheumatism&rft.issn=00043591&rft_id=info:doi/10.1002%2Fart.24980 L2 - http://www3.interscience.wiley.com/journal/123195007/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Antinuclear antibodies; Interleukin 12; Autoantibodies; Autoimmune diseases; Animal models; Transgenic mice; Salivary gland; Lymphoid tissue; Lacrimal gland; xerostomia DO - http://dx.doi.org/10.1002/art.24980 ER - TY - JOUR T1 - Green fiber lasers: An alternative to traditional DPSS green lasers for flow cytometry AN - 745641777; 13157835 AB - Green and yellow diode-pumped solid-state (DPSS) lasers (532 and 561 nm) have become common fixtures on flow cytometers, due to their efficient excitation of phycoerythrin (PE) and its tandems, and their ability to excite an expanding array of expressible red fluorescent proteins. Nevertheless, they have some disadvantages. DPSS 532-nm lasers emit very close to the fluorescein bandwidth, necessitating optical modifications to permit detection of fluorescein and GFP. DPSS 561-nm lasers likewise emit very close to the PE detection bandwidth and also cause unwanted excitation of APC and its tandems, requiring high levels of crossbeam compensation to reduce spectral overlap into the PE tandems. In this article, we report the development of a new generation of green fiber lasers that can be engineered to emit in the range between 532 and 561 nm. A 550-nm green fiber laser was integrated into both a BD LSR IITM cuvette and FACSVantage DiVaTM jet-in-air cell sorter. This laser wavelength avoided both the fluorescein and PE bandwidths and provided better excitation of PE and the red fluorescent proteins DsRed and dTomato than a power-matched 532 nm source. Excitation at 550 nm also caused less incidental excitation of APC and its tandems, reducing the need for crossbeam compensation. Excitation in the 550 nm range, therefore, proved to be a good compromise between 532- and 561-nm sources. Fiber laser technology is, therefore, providing the flexibility necessary for precisely matching laser wavelengths to our flow cytometry applications. Published 2009 Wiley-Liss, Inc. JF - Cytometry Part A AU - Telford, William G AU - Babin, Sergey A AU - Khorev, Serge V AU - Rowe, Stephen H AD - Experimental Transplantation and Immunology Branch, NCI-NIH, Bethesda, Maryland, telfordw@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1031 EP - 1039 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 75A IS - 12 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Fibers KW - phycoerythrins KW - red fluorescent protein KW - Lasers KW - Wavelength KW - fluorescein KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745641777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Green+fiber+lasers%3A+An+alternative+to+traditional+DPSS+green+lasers+for+flow+cytometry&rft.au=Telford%2C+William+G%3BBabin%2C+Sergey+A%3BKhorev%2C+Serge+V%3BRowe%2C+Stephen+H&rft.aulast=Telford&rft.aufirst=William&rft.date=2009-12-01&rft.volume=75A&rft.issue=12&rft.spage=1031&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20790 L2 - http://www3.interscience.wiley.com/journal/122606765/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Flow cytometry; phycoerythrins; Fibers; red fluorescent protein; Lasers; Wavelength; fluorescein DO - http://dx.doi.org/10.1002/cyto.a.20790 ER - TY - JOUR T1 - Characterization of a Novel Relapsing Fever Spirochete in the Midgut, Coxal Fluid, and Salivary Glands of the Bat Tick Carios kelleyi AN - 745640921; 13135342 AB - Bat ticks, Carios kelleyi, from Iowa were examined for the presence of relapsing fever group borreliae. A novel spirochete was characterized by DNA sequence analysis of polymerase chain reaction amplicons for the 16S rRNA, flaB, and glpQ genes in either triturated tick pools or single ticks. All loci and the concatenated DNA sequence of 3,289 bases identified the Carios bacterium as a relapsing fever spirochete most closely related to, but distinct from, Borrelia turicatae. Spirochetes reactive with a Borrelia-specific monoclonal antibody were observed microscopically in the coxal fluid and salivary glands from one tick. These data confirm the presence of a novel species of relapsing fever spirochete in bat ticks and the potential for new enzootic foci for endemic relapsing fever that warrants further investigation. The name Borrelia johnsonii is proposed for this novel spirochete in honor of Dr. Russell C. Johnson. JF - Vector Borne and Zoonotic Diseases AU - Schwan, T G AU - Raffel, S J AU - Schrumpf, ME AU - Gill, J S AU - Piesman, J AD - Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th Street, Hamilton, MT 59840, USA Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 643 EP - 647 VL - 9 IS - 6 SN - 1530-3667, 1530-3667 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Monoclonal antibodies KW - Ixodidae KW - Relapsing fever KW - Nucleotide sequence KW - Vectors KW - Salivary gland KW - Borrelia turicatae KW - Spirochetes KW - Polymerase chain reaction KW - Midgut KW - rRNA 16S KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745640921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Characterization+of+a+Novel+Relapsing+Fever+Spirochete+in+the+Midgut%2C+Coxal+Fluid%2C+and+Salivary+Glands+of+the+Bat+Tick+Carios+kelleyi&rft.au=Schwan%2C+T+G%3BRaffel%2C+S+J%3BSchrumpf%2C+ME%3BGill%2C+J+S%3BPiesman%2C+J&rft.aulast=Schwan&rft.aufirst=T&rft.date=2009-12-01&rft.volume=9&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2008.0177 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Spirochetes; Data processing; Monoclonal antibodies; Nucleotide sequence; Relapsing fever; Polymerase chain reaction; Vectors; Midgut; Salivary gland; rRNA 16S; Ixodidae; Borrelia turicatae DO - http://dx.doi.org/10.1089/vbz.2008.0177 ER - TY - JOUR T1 - Perceptions of Aging Across 26 Cultures and Their Culture-Level Associates AN - 742717343; 201010811 AB - College students (N = 3,435) in 26 cultures reported their perceptions of age-related changes in physical, cognitive, and socioemotional areas of functioning and rated societal views of aging within their culture. There was widespread cross-cultural consensus regarding the expected direction of aging trajectories with (a) perceived declines in societal views of aging, physical attractiveness, the ability to perform everyday tasks, and new learning; (b) perceived increases in wisdom, knowledge, and received respect; and (c) perceived stability in family authority and life satisfaction. Cross-cultural variations in aging perceptions were associated with culture-level indicators of population aging, education levels, values, and national character stereotypes. These associations were stronger for societal views on aging and perceptions of socioemotional changes than for perceptions of physical and cognitive changes. A consideration of culture-level variables also suggested that previously reported differences in aging perceptions between Asian and Western countries may be related to differences in population structure. [Copyright American Psychological Association] JF - Psychology and Aging Psychology and Aging AU - Lockenhoff, Corinna E AU - De Fruyt, Filip AU - Terracciano, Antonio AU - McCrae, Robert R AU - De Bolle, Marleen AU - Costa, Paul T, Jr AU - Aguilar-Vafaie, Maria E AU - Ahn, Chang-kyu AU - Ahn, Hyun-nie AU - Alcalay, Lidia AU - Allik, Juri AU - Avdeyeva, Tatyana V AU - Barbaranelli, Claudio AU - Benet-Martinez, Veronica AU - Blatny, Marek AU - Bratko, Denis AU - Cain, Thomas R AU - Crawford, Jarret T AU - Lima, Margarida P AU - Fickova, Emilia AU - Gheorghiu, Mirona AU - Halberstadt, Jamin AU - Hrebickova, Martina AU - Jussim, Lee AU - Klinkosz, Waldemar AU - Knezevic, Goran AU - de Figueroa, Nora Leibovich AU - Martin, Thomas A AU - Marusic, Iris AU - Mastor, Khairul Anwar AU - Miramontez, Daniel R AU - Nakazato, Katsuharu AU - Nansubuga, Florence AU - Pramila, V S AU - Realo, Anu AU - Rolland, Jean-Pierre AU - Rossier, Jerome AU - Schmidt, Vanina AU - Sekowski, Andrzej AU - Shakespeare-Finch, Jane AU - Shimonaka, Yoshiko AU - Simonetti, Franco AU - Siuta, Jerzy AU - Smith, Peter B AU - Szmigielska, Barbara AU - Wang, Lei AU - Yamaguchi, Mami AU - Yik, Michelle AD - National Institute on Aging, Baltimore, MD Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 941 EP - 954 PB - American Psychological Association, Washington DC VL - 24 IS - 4 SN - 0882-7974, 0882-7974 KW - aging stereotypes cross-cultural values national character stereotypes KW - Ageing KW - Perceptions KW - Crosscultural studies KW - Cultural values KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742717343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging+Psychology+and+Aging&rft.atitle=Perceptions+of+Aging+Across+26+Cultures+and+Their+Culture-Level+Associates&rft.au=Lockenhoff%2C+Corinna+E%3BDe+Fruyt%2C+Filip%3BTerracciano%2C+Antonio%3BMcCrae%2C+Robert+R%3BDe+Bolle%2C+Marleen%3BCosta%2C+Paul+T%2C+Jr%3BAguilar-Vafaie%2C+Maria+E%3BAhn%2C+Chang-kyu%3BAhn%2C+Hyun-nie%3BAlcalay%2C+Lidia%3BAllik%2C+Juri%3BAvdeyeva%2C+Tatyana+V%3BBarbaranelli%2C+Claudio%3BBenet-Martinez%2C+Veronica%3BBlatny%2C+Marek%3BBratko%2C+Denis%3BCain%2C+Thomas+R%3BCrawford%2C+Jarret+T%3BLima%2C+Margarida+P%3BFickova%2C+Emilia%3BGheorghiu%2C+Mirona%3BHalberstadt%2C+Jamin%3BHrebickova%2C+Martina%3BJussim%2C+Lee%3BKlinkosz%2C+Waldemar%3BKnezevic%2C+Goran%3Bde+Figueroa%2C+Nora+Leibovich%3BMartin%2C+Thomas+A%3BMarusic%2C+Iris%3BMastor%2C+Khairul+Anwar%3BMiramontez%2C+Daniel+R%3BNakazato%2C+Katsuharu%3BNansubuga%2C+Florence%3BPramila%2C+V+S%3BRealo%2C+Anu%3BRolland%2C+Jean-Pierre%3BRossier%2C+Jerome%3BSchmidt%2C+Vanina%3BSekowski%2C+Andrzej%3BShakespeare-Finch%2C+Jane%3BShimonaka%2C+Yoshiko%3BSimonetti%2C+Franco%3BSiuta%2C+Jerzy%3BSmith%2C+Peter+B%3BSzmigielska%2C+Barbara%3BWang%2C+Lei%3BYamaguchi%2C+Mami%3BYik%2C+Michelle&rft.aulast=Lockenhoff&rft.aufirst=Corinna&rft.date=2009-12-01&rft.volume=24&rft.issue=4&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging+Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2Fa0016901 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Ageing; Cultural values; Perceptions; Stereotypes; Crosscultural studies DO - http://dx.doi.org/10.1037/a0016901 ER - TY - JOUR T1 - Perspective on potential clinical applications of recombinant human interleukin-7. AN - 734236555; 20074272 AB - Interleukin-7 has critical and nonredundant roles in T cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple therapeutic applications in immunodeficiency states, either physiologic (immuno-senescence), pathologic (HIV) or iatrogenic (postchemotherapy and posthematopoietic stem cell transplant) and may have roles in immune reconstitution or enhancement of immunotherapy. Early clinical development trials in humans show that, within a short time, rhIL-7 administration results in a marked preferential expansion of both naive and memory CD4 and CD8 T cell pools with a tendency toward enhanced CD8 expansion. As a result, lymphopenic or normal older hosts develop an expanded circulating T cell pool with a profile that resembles that seen earlier in life with increased T cell repertoire diversity. These results, along with a favorable toxicity profile, open a wide perspective of potential future clinical applications. JF - Annals of the New York Academy of Sciences AU - Sportès, Claude AU - Gress, Ronald E AU - Mackall, Crystal L AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1104, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 28 EP - 38 VL - 1182 KW - Interleukin-7 KW - 0 KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - T-Lymphocytes -- cytology KW - Recombinant Proteins -- pharmacology KW - Immunotherapy KW - Humans KW - Recombinant Proteins -- immunology KW - Clinical Trials as Topic KW - T-Lymphocytes -- drug effects KW - Cell Differentiation -- drug effects KW - T-Lymphocytes -- immunology KW - Recombinant Proteins -- therapeutic use KW - Interleukin-7 -- therapeutic use KW - Interleukin-7 -- immunology KW - Interleukin-7 -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734236555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Perspective+on+potential+clinical+applications+of+recombinant+human+interleukin-7.&rft.au=Sport%C3%A8s%2C+Claude%3BGress%2C+Ronald+E%3BMackall%2C+Crystal+L&rft.aulast=Sport%C3%A8s&rft.aufirst=Claude&rft.date=2009-12-01&rft.volume=1182&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.03.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-22 N1 - Date created - 2010-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1749-6632.2009.05075.x ER - TY - JOUR T1 - Dose-response modeling of high-throughput screening data. AN - 734196376; 19828774 AB - The National Toxicology Program is developing a high-throughput screening (HTS) program to set testing priorities for compounds of interest, to identify mechanisms of action, and potentially to develop predictive models for human toxicity. This program will generate extensive data on the activity of large numbers of chemicals in a wide variety of biochemical- and cell-based assays. The first step in relating patterns of response among batteries of HTS assays to in vivo toxicity is to distinguish between positive and negative compounds in individual assays. Here, the authors report on a statistical approach developed to identify compounds positive or negative in an HTS cytotoxicity assay based on data collected from screening 1353 compounds for concentration-response effects in 9 human and 4 rodent cell types. In this approach, the authors develop methods to normalize the data (removing bias due to the location of the compound on the 1536-well plates used in the assay) and to analyze for concentration-response relationships. Various statistical tests for identifying significant concentration-response relationships and for addressing reproducibility are developed and presented. JF - Journal of biomolecular screening AU - Parham, Fred AU - Austin, Chris AU - Southall, Noel AU - Huang, Ruili AU - Tice, Raymond AU - Portier, Christopher AD - National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, USA. parham@niehs.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1216 EP - 1227 VL - 14 IS - 10 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Humans KW - Cell Line KW - Dose-Response Relationship, Drug KW - High-Throughput Screening Assays -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734196376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+screening&rft.atitle=Dose-response+modeling+of+high-throughput+screening+data.&rft.au=Parham%2C+Fred%3BAustin%2C+Chris%3BSouthall%2C+Noel%3BHuang%2C+Ruili%3BTice%2C+Raymond%3BPortier%2C+Christopher&rft.aulast=Parham&rft.aufirst=Fred&rft.date=2009-12-01&rft.volume=14&rft.issue=10&rft.spage=1216&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+screening&rft.issn=1552-454X&rft_id=info:doi/10.1177%2F1087057109349355 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-18 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Risk Anal. 1993 Oct;13(5):565-72 [8259447] Toxicol Appl Pharmacol. 2004 Jan 15;194(2):156-68 [14736496] J Biomol Screen. 2003 Oct;8(5):566-70 [14567784] J Cardiovasc Pharmacol Ther. 2001 Apr;6(2):201-12 [11509927] Anal Biochem. 2005 May 1;340(1):1-13 [15802124] J Biomol Screen. 2008 Feb;13(2):159-67 [18216390] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Nat Biotechnol. 2006 Feb;24(2):167-75 [16465162] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1087057109349355 ER - TY - JOUR T1 - Summary results and recommendations from the age-related eye disease study. AN - 734194196; 20008727 JF - Archives of ophthalmology (Chicago, Ill. : 1960) AU - Chew, Emily Y AU - Lindblad, Anne S AU - Clemons, Traci AU - Age-Related Eye Disease Study Research Group AD - Division of Epidemiology and Clinical Applications, National Institutes of Health, 10 Center Dr, Bldg 10, Clinical Research Center Room 3-2531, Mail Stop Center 1204, Bethesda, MD 20892-1204, USA. echew@nei.nih.gov ; Age-Related Eye Disease Study Research Group Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1678 EP - 1679 VL - 127 IS - 12 KW - Antioxidants KW - 0 KW - Vitamins KW - Zinc KW - J41CSQ7QDS KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Clinical Trials as Topic KW - Dietary Supplements KW - Antioxidants -- adverse effects KW - Zinc -- administration & dosage KW - Macular Degeneration -- prevention & control KW - Vitamins -- adverse effects KW - Vitamins -- administration & dosage KW - Cataract -- prevention & control KW - Practice Guidelines as Topic KW - Zinc -- adverse effects KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734194196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Summary+results+and+recommendations+from+the+age-related+eye+disease+study.&rft.au=Chew%2C+Emily+Y%3BLindblad%2C+Anne+S%3BClemons%2C+Traci%3BAge-Related+Eye+Disease+Study+Research+Group&rft.aulast=Chew&rft.aufirst=Emily&rft.date=2009-12-01&rft.volume=127&rft.issue=12&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=1538-3601&rft_id=info:doi/10.1001%2Farchophthalmol.2009.312 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-24 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Ophthalmol. 2001 Oct;119(10):1417-36 [11594942] Arch Ophthalmol. 2001 Oct;119(10):1439-52 [11594943] Arch Ophthalmol. 2003 Nov;121(11):1621-4 [14609922] Arch Ophthalmol. 2004 Apr;122(4):477-85 [15078664] Arch Ophthalmol. 2004 Apr;122(4):564-72 [15078675] Arch Ophthalmol. 2005 Nov;123(11):1570-4 [16286620] N Engl J Med. 1994 Apr 14;330(15):1029-35 [8127329] N Engl J Med. 1996 May 2;334(18):1150-5 [8602180] Neurology. 2004 Nov 9;63(9):1705-7 [15534261] Arch Ophthalmol. 2005 Nov;123(11):1484-98 [16286610] Arch Ophthalmol. 2004 May;122(5):716-26 [15136320] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archophthalmol.2009.312 ER - TY - JOUR T1 - Clinical features of spinal and bulbar muscular atrophy. AN - 734192492; 19846582 AB - Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. To characterize the natural history and define outcome measures for clinical trials, we assessed the clinical history, laboratory findings and muscle strength and function in 57 patients with genetically confirmed disease. We also administered self-assessment questionnaires for activities of daily living, quality of life and erectile function. We found an average delay of over 5 years from onset of weakness to diagnosis. Muscle strength and function correlated directly with serum testosterone levels and inversely with CAG repeat length, age and duration of weakness. Motor unit number estimation was decreased by about half compared to healthy controls. Sensory nerve action potentials were reduced in nearly all subjects. Quantitative muscle assessment and timed 2 min walk may be useful as meaningful indicators of disease status. The direct correlation of testosterone levels with muscle strength indicates that androgens may have a positive effect on muscle function in spinal and bulbar muscular atrophy patients, in addition to the toxic effects described in animal models. JF - Brain : a journal of neurology AU - Rhodes, Lindsay E AU - Freeman, Brandi K AU - Auh, Sungyoung AU - Kokkinis, Angela D AU - La Pean, Alison AU - Chen, Cheunju AU - Lehky, Tanya J AU - Shrader, Joseph A AU - Levy, Ellen W AU - Harris-Love, Michael AU - Di Prospero, Nicholas A AU - Fischbeck, Kenneth H AD - Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 3242 EP - 3251 VL - 132 KW - Androgens KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Abridged Index Medicus KW - Index Medicus KW - Androgens -- therapeutic use KW - Action Potentials -- physiology KW - Peripheral Nerves -- physiopathology KW - Age of Onset KW - Muscle Strength -- physiology KW - Humans KW - Quality of Life KW - Activities of Daily Living KW - Aged KW - Erectile Dysfunction -- etiology KW - Neural Conduction -- physiology KW - Exercise Tolerance -- physiology KW - Electrodiagnosis KW - Electromyography -- methods KW - Testosterone -- blood KW - Adult KW - Erectile Dysfunction -- physiopathology KW - Surveys and Questionnaires KW - Erectile Dysfunction -- diagnosis KW - Middle Aged KW - Testosterone -- analysis KW - Time Factors KW - Male KW - Muscle, Skeletal -- pathology KW - Muscle Weakness -- physiopathology KW - Muscle Weakness -- genetics KW - Muscle, Skeletal -- physiopathology KW - Bulbo-Spinal Atrophy, X-Linked -- diagnosis KW - Muscle Weakness -- diagnosis KW - Bulbo-Spinal Atrophy, X-Linked -- physiopathology KW - Bulbo-Spinal Atrophy, X-Linked -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734192492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%3A+a+journal+of+neurology&rft.atitle=Clinical+features+of+spinal+and+bulbar+muscular+atrophy.&rft.au=Rhodes%2C+Lindsay+E%3BFreeman%2C+Brandi+K%3BAuh%2C+Sungyoung%3BKokkinis%2C+Angela+D%3BLa+Pean%2C+Alison%3BChen%2C+Cheunju%3BLehky%2C+Tanya+J%3BShrader%2C+Joseph+A%3BLevy%2C+Ellen+W%3BHarris-Love%2C+Michael%3BDi+Prospero%2C+Nicholas+A%3BFischbeck%2C+Kenneth+H&rft.aulast=Rhodes&rft.aufirst=Lindsay&rft.date=2009-12-01&rft.volume=132&rft.issue=&rft.spage=3242&rft.isbn=&rft.btitle=&rft.title=Brain+%3A+a+journal+of+neurology&rft.issn=1460-2156&rft_id=info:doi/10.1093%2Fbrain%2Fawp258 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-10 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Can J Aging. 2007 Summer;26(2):159-62 [17613447] Exp Neurol. 2006 Jul;200(1):8-18 [16513111] Brain. 2008 Jan;131(Pt 1):229-39 [18056738] Ann Neurol. 2009 Feb;65(2):140-50 [19259967] Muscle Nerve. 2009 Nov;40(5):809-14 [19670325] Muscle Nerve. 2000 Feb;23(2):252-8 [10639619] Muscle Nerve. 2000 Jun;23(6):843-50 [10842259] Eur J Hum Genet. 2000 Aug;8(8):631-6 [10951525] Arch Phys Med Rehabil. 2001 Jan;82(1):9-13 [11239279] Int J Impot Res. 2002 Aug;14(4):226-44 [12152111] J Clin Endocrinol Metab. 2002 Aug;87(8):3893-901 [12161529] Neurology. 2002 Sep 10;59(5):770-2 [12221177] Neuron. 2002 Aug 29;35(5):843-54 [12372280] J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):710-4 [12754336] Can J Neurol Sci. 2003 May;30(2):129-36 [12774952] Nat Med. 2003 Jun;9(6):768-73 [12754502] J Neurosci. 2004 May 19;24(20):4778-86 [15152038] Muscle Nerve. 2004 Oct;30(4):463-9 [15316983] Neurology. 1968 Jul;18(7):671-80 [4233749] Nature. 1991 Jul 4;352(6330):77-9 [2062380] Nat Genet. 1992 Dec;2(4):301-4 [1303283] J Neurol Sci. 1993 Jul;117(1-2):74-8 [8410070] Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov;4(7):735-41 [8672990] Hum Mol Genet. 1996 Sep;5(9):1253-7 [8872464] J Neurol Sci. 1996 Aug;139 Suppl:64-70 [8899661] Muscle Nerve. 1997 Mar;20(3):323-9 [9052811] Urology. 1997 Jun;49(6):822-30 [9187685] Urology. 1999 Apr;53(4):800-5 [10197860] Arch Neurol. 1965 Jun;12:597-603 [14295959] Neurology. 2005 Apr 12;64(7):1261-2 [15824358] Andrologia. 2006 Apr;38(2):48-53 [16529575] J Clin Endocrinol Metab. 2006 Apr;91(4):1336-44 [16368750] Brain. 2006 Jun;129(Pt 6):1446-55 [16621916] BJU Int. 2007 Aug;100(2):321-6 [17506868] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/brain/awp258 ER - TY - JOUR T1 - Targeting Cdk5 activity in neuronal degeneration and regeneration. AN - 734192245; 19455415 AB - The major priming event in neurodegeneration is loss of neurons. Loss of neurons by apoptotic mechanisms is a theme for studies focused on determining therapeutic strategies. Neurons following an insult, activate a number of signal transduction pathways, of which, kinases are the leading members. Cyclin-dependent kinase 5 (Cdk5) is one of the kinases that have been linked to neurodegeneration. Cdk5 along with its principal activator p35 is involved in multiple cellular functions ranging from neuronal differentiation and migration to synaptic transmission. However, during neurotoxic stress, intracellular rise in Ca(2+) activates calpain, which cleaves p35 to generate p25. The long half-life of Cdk5/p25 results in a hyperactive, aberrant Cdk5 that hyperphosphorylates Tau, neurofilament and other cytoskeletal proteins. These hyperphosphorylated cytoskeletal proteins set the groundwork to forming neurofibrillary tangles and aggregates of phosphorylated proteins, hallmarks of neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Amyotropic Lateral Sclerosis. Attempts to selectively target Cdk5/p25 activity without affecting Cdk5/p35 have been largely unsuccessful. A polypeptide inhibitor, CIP (Cdk5 inhibitory peptide), developed in our laboratory, successfully inhibits Cdk5/p25 activity in vitro, in cultured primary neurons, and is currently undergoing validation tests in mouse models of neurodegeneration. Here, we discuss the therapeutic potential of CIP in regenerating neurons that are exposed to neurodegenerative stimuli. JF - Cellular and molecular neurobiology AU - Kanungo, Jyotshnabala AU - Zheng, Ya-li AU - Amin, Niranjana D AU - Pant, Harish C AD - Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1073 EP - 1080 VL - 29 IS - 8 KW - Enzyme Activators KW - 0 KW - Peptides KW - Cyclin-Dependent Kinase 5 KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Enzyme Induction -- drug effects KW - Mice KW - Peptides -- pharmacology KW - Enzyme Activators -- pharmacology KW - Nerve Regeneration -- physiology KW - Nerve Regeneration -- drug effects KW - Cyclin-Dependent Kinase 5 -- antagonists & inhibitors KW - Nerve Degeneration -- enzymology KW - Cyclin-Dependent Kinase 5 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734192245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+neurobiology&rft.atitle=Targeting+Cdk5+activity+in+neuronal+degeneration+and+regeneration.&rft.au=Kanungo%2C+Jyotshnabala%3BZheng%2C+Ya-li%3BAmin%2C+Niranjana+D%3BPant%2C+Harish+C&rft.aulast=Kanungo&rft.aufirst=Jyotshnabala&rft.date=2009-12-01&rft.volume=29&rft.issue=8&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+neurobiology&rft.issn=1573-6830&rft_id=info:doi/10.1007%2Fs10571-009-9410-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-17 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10571-009-9410-6 ER - TY - JOUR T1 - Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. AN - 734176112; 19995279 AB - The mechanism(s) by which chronic inhalation of indium phosphide (InP) particles causes pleural fibrosis is not known. Few studies of InP pleural toxicity have been conducted because of the challenges in conducting particulate inhalation exposures, and because the pleural lesions developed slowly over the 2-year inhalation study. The authors investigated whether InP (1 mg/kg) administered by a single oropharyngeal aspiration would cause pleural fibrosis in male B6C3F1 mice. By 28 days after treatment, protein and lactate dehydrogenase (LDH) were significantly increased in bronchoalveolar lavage fluid (BALF), but were unchanged in pleural lavage fluid (PLF). A pronounced pleural effusion characterized by significant increases in cytokines and a 3.7-fold increase in cell number was detected 28 days after InP treatment. Aspiration of soluble InCl(3) caused a similar delayed pleural effusion; however, other soluble metals, insoluble particles, and fibers did not. The effusion caused by InP was accompanied by areas of pleural thickening and inflammation at day 28, and by pleural fibrosis at day 98. Aspiration of InP produced pleural fibrosis that was histologically similar to lesions caused by chronic inhalation exposure, and in a shorter time period. This oropharyngeal aspiration model was used to provide an initial characterization of the progression of pleural lesions caused by InP. JF - Experimental lung research AU - Kirby, Patrick J AU - Shines, Cassandra J AU - Taylor, Genie J AU - Bousquet, Ronald W AU - Price, Herman C AU - Everitt, Jeffrey I AU - Morgan, Daniel L AD - Respiratory Toxicology, Laboratory of Molecular Toxicology, Environmental Toxicology Program/National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 858 EP - 882 VL - 35 IS - 10 KW - Cytokines KW - 0 KW - Particulate Matter KW - Phosphines KW - Indium KW - 045A6V3VFX KW - indium phosphide KW - 22398-80-7 KW - indium trichloride KW - 31JB8MKF8Z KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Pleurisy -- pathology KW - Animals KW - Pleurisy -- etiology KW - Pleural Effusion -- pathology KW - Fibrosis KW - Disease Models, Animal KW - Pleural Effusion -- metabolism KW - Cytokines -- metabolism KW - Mice KW - Pleural Effusion -- etiology KW - Particulate Matter -- toxicity KW - Pleurisy -- metabolism KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Particulate Matter -- administration & dosage KW - Inhalation Exposure KW - Administration, Inhalation KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - L-Lactate Dehydrogenase -- metabolism KW - Male KW - Indium -- toxicity KW - Phosphines -- administration & dosage KW - Pleura -- drug effects KW - Pleura -- pathology KW - Phosphines -- toxicity KW - Indium -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734176112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Pleural+effects+of+indium+phosphide+in+B6C3F1+mice%3A+nonfibrous+particulate+induced+pleural+fibrosis.&rft.au=Kirby%2C+Patrick+J%3BShines%2C+Cassandra+J%3BTaylor%2C+Genie+J%3BBousquet%2C+Ronald+W%3BPrice%2C+Herman+C%3BEveritt%2C+Jeffrey+I%3BMorgan%2C+Daniel+L&rft.aulast=Kirby&rft.aufirst=Patrick&rft.date=2009-12-01&rft.volume=35&rft.issue=10&rft.spage=858&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=1521-0499&rft_id=info:doi/10.3109%2F01902140902980961 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fukuoka Igaku Zasshi. 2000 Jan;91(1):21-33 [10714013] Exp Lung Res. 2009 Dec;35(10):858-82 [19995279] Curr Opin Pulm Med. 2001 Jul;7(4):180-2 [11470970] Natl Toxicol Program Tech Rep Ser. 2001 Jul;(499):7-340 [12087422] Eur Respir J. 2003 Mar;21(3):539-44 [12662014] J Occup Health. 2003 May;45(3):137-9 [14646287] Paediatr Respir Rev. 2004;5 Suppl A:S201-3 [14980271] Anal Biochem. 1976 May 7;72:248-54 [942051] Thorax. 1987 Aug;42(8):583-8 [3660310] Br J Exp Pathol. 1988 Oct;69(5):717-37 [2848570] Environ Health Perspect. 1992 Jul;97:145-7 [1396450] Fukuoka Igaku Zasshi. 1996 May;87(5):108-15 [8690334] Environ Res. 1995 Oct;71(1):16-24 [8757234] Fundam Appl Toxicol. 1996 Jul;32(1):72-8 [8812231] Ind Health. 1997;35(1):61-8 [9009503] Eur J Cell Biol. 1997 Oct;74(2):111-22 [9352216] Am J Respir Cell Mol Biol. 1999 Jan;20(1):135-42 [9870927] Inhal Toxicol. 1999 Sep;11(9):747-84 [10477658] Br J Ind Med. 1960 Oct;17:260-71 [13782506] Med J Aust. 1962 Dec 15;49(2):953-4 [13932248] Respirology. 2004 Nov;9(4):428-40 [15612953] Respirology. 2004 Nov;9(4):441-7 [15612954] Eur Respir J. 2005 Jan;25(1):104-9 [15640330] Eur Respir J. 2005 Jan;25(1):200-4 [15640342] Clin Chest Med. 2006 Jun;27(2):181-91 [16716812] J Immunol. 2006 Jul 1;177(1):621-30 [16785560] Curr Opin Pulm Med. 2006 Jul;12(4):251-8 [16825876] Nihon Kokyuki Gakkai Zasshi. 2006 Jul;44(7):532-6 [16886812] Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L651-7 [16728527] Eur Respir J. 2007 Feb;29(2):317-24 [17050566] Am J Respir Cell Mol Biol. 2007 Sep;37(3):300-8 [17496151] J Immunol. 2007 Nov 1;179(9):6043-51 [17947678] Occup Environ Med. 2008 Jan;65(1):51-5 [17626138] Respiration. 2008;75(2):121-33 [18332619] J Appl Physiol (1985). 2001 Mar;90(3):1111-7 [11181627] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/01902140902980961 ER - TY - JOUR T1 - DNA methylation of cancer genome. AN - 734175218; 19960550 AB - DNA methylation plays an important role in regulating normal development and carcinogenesis. Current understanding of the biological roles of DNA methylation is limited to its role in the regulation of gene transcription, genomic imprinting, genomic stability, and X chromosome inactivation. In the past 2 decades, a large number of changes have been identified in cancer epigenomes when compared with normals. These alterations fall into two main categories, namely, hypermethylation of tumor suppressor genes and hypomethylation of oncogenes or heterochromatin, respectively. Aberrant methylation of genes controlling the cell cycle, proliferation, apoptosis, metastasis, drug resistance, and intracellular signaling has been identified in multiple cancer types. Recent advancements in whole-genome analysis of methylome have yielded numerous differentially methylated regions, the functions of which are largely unknown. With the development of high resolution tiling microarrays and high throughput DNA sequencing, more cancer methylomes will be profiled, facilitating the identification of new candidate genes or ncRNAs that are related to oncogenesis, new prognostic markers, and the discovery of new target genes for cancer therapy. JF - Birth defects research. Part C, Embryo today : reviews AU - Cheung, Hoi-Hung AU - Lee, Tin-Lap AU - Rennert, Owen M AU - Chan, Wai-Yee AD - Section on Developmental Genomics, Laboratory of Clinical Genomics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 335 EP - 350 VL - 87 IS - 4 KW - RNA, Neoplasm KW - 0 KW - RNA, Untranslated KW - Index Medicus KW - Animals KW - Genomics -- methods KW - Genes, Tumor Suppressor KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - RNA, Neoplasm -- genetics KW - RNA, Untranslated -- genetics KW - Genome KW - Pregnancy KW - Oncogenes KW - Genomic Instability KW - Chromatin Immunoprecipitation -- methods KW - Repetitive Sequences, Nucleic Acid KW - Female KW - Male KW - Embryonic Development -- genetics KW - DNA Methylation -- genetics KW - Epigenesis, Genetic KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734175218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=DNA+methylation+of+cancer+genome.&rft.au=Cheung%2C+Hoi-Hung%3BLee%2C+Tin-Lap%3BRennert%2C+Owen+M%3BChan%2C+Wai-Yee&rft.aulast=Cheung&rft.aufirst=Hoi-Hung&rft.date=2009-12-01&rft.volume=87&rft.issue=4&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542-9768&rft_id=info:doi/10.1002%2Fbdrc.20163 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 May 10;102(19):6948-53 [15870198] Int J Cancer. 2005 Aug 20;116(2):200-6 [15800911] World J Gastroenterol. 2005 Jul 7;11(25):3834-41 [15991278] Nat Genet. 2005 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May;65(1):41-50 [12658632] Int J Cancer. 2003 Jun 10;105(2):204-9 [12673680] Prostate. 2003 May 15;55(3):199-205 [12692786] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/bdrc.20163 ER - TY - JOUR T1 - The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells. AN - 734169763; 19934343 AB - EP4 expression in human glioblastoma cells correlates with growth on soft agar. The cyclooxygenase inhibitor sulindac sulfide first altered specificity protein-1 (Sp-1) and early growth response gene-1 expression, then increased the expression of nonsteroidal anti-inflammatory drug-activated gene 1 and activating transcription factor 3, and then decreased EP4 expression. EP4 suppression was dependent on blocking the Sp-1 binding sites in the human EP4 promoter. Mutation in the Sp-1 sites in EP4 altered the promoter activity and abolished sulindac sulfide effects. The inhibitory effect of sulindac sulfide on EP4 expression was reversed by PD98059, a mitogen-activated protein/extracellular signal-regulated kinase kinase-1/extracellular signal-regulated kinase inhibitor. Sp-1 phosphorylation was dependent on sulindac sulfide-induced Erk activation. Chromatin immunoprecipitation assay confirmed that Sp-1 phosphorylation decreases Sp-1 binding to DNA and leads to the suppression of EP4. Inhibition of cell growth on soft agar assay was found to be a highly complex process and seems to require not only the inhibition of cyclooxygenase activity but also increased expression of nonsteroidal anti-inflammatory drug-activated gene 1 and activating transcription factor 3 and suppression of EP4 expression. Our data suggest that the suppression of EP4 expression by sulindac sulfide represents a new mechanism for understanding the tumor suppressor activity. JF - Cancer prevention research (Philadelphia, Pa.) AU - Kambe, Atsushi AU - Yoshioka, Hiroki AU - Kamitani, Hideki AU - Watanabe, Takashi AU - Baek, Seung Joon AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1088 EP - 1099 VL - 2 IS - 12 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Activating Transcription Factor 3 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Cyclooxygenase Inhibitors KW - Early Growth Response Protein 1 KW - Flavonoids KW - NAG protein, human KW - Neoplasm Proteins KW - PTGER4 protein, human KW - RNA, Messenger KW - RNA, Small Interfering KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP4 Subtype KW - Sp1 Transcription Factor KW - Sulindac KW - 184SNS8VUH KW - sulindac sulfide KW - 6UVA8S2DEY KW - Luciferases KW - EC 1.13.12.- KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinases KW - Index Medicus KW - Activating Transcription Factor 3 -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Humans KW - Immunoprecipitation KW - Luciferases -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Blotting, Western KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Phosphorylation KW - Early Growth Response Protein 1 -- metabolism KW - Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors KW - Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors KW - Sp1 Transcription Factor -- metabolism KW - Chromatin Immunoprecipitation KW - RNA, Small Interfering -- pharmacology KW - Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Promoter Regions, Genetic -- genetics KW - Flavonoids -- pharmacology KW - Colony-Forming Units Assay KW - Neoplasm Proteins -- metabolism KW - Receptors, Prostaglandin E -- metabolism KW - Receptors, Prostaglandin E -- antagonists & inhibitors KW - Receptors, Prostaglandin E -- genetics KW - Brain Neoplasms -- pathology KW - Glioblastoma -- pathology KW - Sulindac -- pharmacology KW - Sulindac -- analogs & derivatives KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734169763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=The+cyclooxygenase+inhibitor+sulindac+sulfide+inhibits+EP4+expression+and+suppresses+the+growth+of+glioblastoma+cells.&rft.au=Kambe%2C+Atsushi%3BYoshioka%2C+Hiroki%3BKamitani%2C+Hideki%3BWatanabe%2C+Takashi%3BBaek%2C+Seung+Joon%3BEling%2C+Thomas+E&rft.aulast=Kambe&rft.aufirst=Atsushi&rft.date=2009-12-01&rft.volume=2&rft.issue=12&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-09-0140 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-16 N1 - Date created - 2009-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):591-6 [14688410] Prog Lipid Res. 2006 Jan;45(1):1-16 [16337272] Am J Obstet Gynecol. 2003 Nov;189(5):1501-10 [14634592] J Biol Chem. 2005 Nov 4;280(44):37266-77 [16105842] J Pharmacol Exp Ther. 2005 Nov;315(2):668-77 [16079301] J Biol Chem. 2005 Sep 30;280(39):33240-9 [16061473] Mol Cancer Ther. 2005 May;4(5):693-703 [15897233] Gene. 2005 Mar 28;348:1-11 [15777659] Mol Cancer Ther. 2005 Mar;4(3):487-93 [15767558] J Cell Biochem. 2005 Feb 15;94(3):597-610 [15546138] Mol Pharmacol. 2005 Feb;67(2):356-64 [15509713] Exp Cell Res. 2005 Jan 15;302(2):244-52 [15561105] JAMA. 1999 Oct 6;282(13):1254-7 [10517428] Biochem J. 1999 Apr 1;339 ( Pt 1):135-41 [10085237] Cancer Res. 1999 Mar 1;59(5):987-90 [10070951] Genomics. 1996 Jul 1;35(1):182-8 [8661119] Mol Cell Biol. 1996 Apr;16(4):1659-67 [8657141] J Biol Chem. 1996 Jan 12;271(2):901-6 [8557703] J Biol Chem. 2003 Jul 11;278(28):25790-801 [12734198] Mol Pharmacol. 2003 Feb;63(2):401-8 [12527812] J Biol Chem. 2002 Jun 7;277(23):20631-9 [11904305] Cancer Res. 2002 Feb 1;62(3):632-5 [11830510] J Neurochem. 2001 Dec;79(5):950-8 [11739606] Nat Med. 2001 Sep;7(9):1048-51 [11533709] Cancer Res. 2001 Jun 1;61(11):4375-81 [11389063] Mol Pharmacol. 2001 Apr;59(4):901-8 [11259636] Mol Cancer Ther. 2008 Dec;7(12):3739-50 [19074849] Biochim Biophys Acta. 2008 Jun;1783(6):1211-9 [18346464] J Biochem Mol Biol. 2006 Nov 30;39(6):649-55 [17129398] J Neurooncol. 2006 May;78(1):85-90 [16391896] Carcinogenesis. 2006 May;27(5):972-81 [16286461] Arch Neurol. 2006 Mar;63(3):337-41 [16533960] J Biol Chem. 2004 Jan 23;279(4):2377-82 [14593115] Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):212-21 [14734472] Biochem Biophys Res Commun. 2004 Feb 20;314(4):1093-9 [14751245] Clin Cancer Res. 2004 Jan 15;10(2):538-45 [14760075] J Biol Chem. 2004 Feb 20;279(8):6883-92 [14662774] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-09-0140 ER - TY - JOUR T1 - Distinct effects of calorie restriction and exercise on mammary gland gene expression in C57BL/6 mice. AN - 734169728; 19952363 AB - Energy balance, including diet, weight, adiposity, and physical activity, is associated with carcinogenesis. Epidemiologic studies indicate that obesity and sedentary and/or active behavior are risk factors for breast cancer in postmenopausal women and survival in both premenopausal and postmenopausal breast cancer patients. Thus, understanding the influence of energy balance modulation on changes in gene expression patterns in the normal mammary gland is important for understanding mechanisms linking energy balance and breast cancer. In a 6-week-long study, female C57BL/6 mice (9-week-old) were randomized into four groups: (a) food consumed ad libitum (AL), (b) AL with access to running wheels (AL+EX), (c) 30% calorie restricted (CR), and (d) 30% CR with access to running wheels (CR+EX). CR mice received 70% of calories but 100% of all other nutrients compared with AL mice. Diet and exercise treatments, individually and combined, had significant effects on body composition and physical activity. Affymetrix oligomicroarrays were used to explore changes in gene expression patterns in total RNA samples from excised whole mammary glands. Contrasting AL versus CR resulted in 425 statistically significant expression changes, whereas AL versus AL+EX resulted in 45 changes, with only 3 changes included among the same genes, indicating that CR and EX differentially influence expression patterns in noncancerous mammary tissue. Differential expression was observed in genes related to breast cancer stem cells, the epithelial-mesenchymal transition, and the growth and survival of breast cancer cells. Thus, CR and EX seem to exert their effects on mammary carcinogenesis through distinct pathways. JF - Cancer prevention research (Philadelphia, Pa.) AU - Padovani, Michela AU - Lavigne, Jackie A AU - Chandramouli, Gadisetti V R AU - Perkins, Susan N AU - Barrett, J Carl AU - Hursting, Stephen D AU - Bennett, L Michelle AU - Berrigan, David AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1076 EP - 1087 VL - 2 IS - 12 KW - Biomarkers KW - 0 KW - RNA, Messenger KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Index Medicus KW - Phenotype KW - Animals KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Mice, Inbred C57BL KW - Insulin-Like Growth Factor I -- metabolism KW - Energy Intake KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Female KW - Gene Expression Profiling KW - Mammary Glands, Animal -- physiology KW - Caloric Restriction KW - Biomarkers -- metabolism KW - Physical Conditioning, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734169728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Distinct+effects+of+calorie+restriction+and+exercise+on+mammary+gland+gene+expression+in+C57BL%2F6+mice.&rft.au=Padovani%2C+Michela%3BLavigne%2C+Jackie+A%3BChandramouli%2C+Gadisetti+V+R%3BPerkins%2C+Susan+N%3BBarrett%2C+J+Carl%3BHursting%2C+Stephen+D%3BBennett%2C+L+Michelle%3BBerrigan%2C+David&rft.aulast=Padovani&rft.aufirst=Michela&rft.date=2009-12-01&rft.volume=2&rft.issue=12&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-09-0034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-16 N1 - Date created - 2009-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Feb 9;80(4):523-6 [9935151] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 [10359783] Biochem Biophys Res Commun. 1999 Jun 16;259(3):695-8 [10364481] Breast Cancer Res Treat. 2004 Aug;86(3):191-6 [15567935] Mol Cell Neurosci. 2005 Mar;28(3):462-74 [15737737] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):1020-1 [15824183] J Nutr. 2005 Jun;135(6):1343-6 [15930435] Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1496-501 [15941962] In Vivo. 2005 Jul-Aug;19(4):667-74 [15999532] Transgenic Res. 2005 Dec;14(6):919-40 [16315096] J Nutr. 2005 Dec;135(12 Suppl):3002S-3008S [16317161] Obes Rev. 2006 Feb;7(1):33-47 [16436101] DNA Cell Biol. 2006 Feb;25(2):79-86 [16460231] Mol Endocrinol. 2006 May;20(5):1177-87 [16469767] Expert Rev Mol Med. 2006;8(18):1-11 [16887048] Obesity (Silver Spring). 2006 Aug;14(8):1294-302 [16988071] Carcinogenesis. 2006 Oct;27(10):2103-7 [16699175] Exp Biol Med (Maywood). 2007 Apr;232(4):473-80 [17392482] Cell Cycle. 2007 May 15;6(10):1249-56 [17495526] Med Hypotheses. 2008;70(2):244-51 [17658223] J Nutr. 2008 Jun;138(6):1033-8 [18492830] Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S530-50; discussion S609-10 [11427781] Biochem Pharmacol. 2000 Jan 1;59(1):43-5 [10605933] Obes Res. 2000 Aug;8(5):392-8 [10968731] Med Sci Sports Exerc. 2000 Oct;32(10):1704-8 [11039641] Biochem Biophys Res Commun. 2002 Apr 26;293(1):622-8 [12054648] Biochim Biophys Acta. 2002 Oct 21;1592(2):107-16 [12379472] J Nutr. 2002 Nov;132(11 Suppl):3456S-3464S [12421870] J Natl Cancer Inst. 2002 Nov 20;94(22):1704-11 [12441326] Annu Rev Med. 2003;54:131-52 [12525670] Curr Opin Cell Biol. 2003 Apr;15(2):158-63 [12648671] Recent Prog Horm Res. 2003;58:297-323 [12795425] Genome Biol. 2003;4(10):R70 [14519205] Med Sci Sports Exerc. 2003 Oct;35(10):1662-9 [14523302] Endocrinology. 2003 Nov;144(11):4773-82 [12960083] Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1206-14 [15247132] Nat Rev Cancer. 2004 Aug;4(8):579-91 [15286738] Mol Carcinog. 2004 Oct;41(2):108-119 [15378649] Cells Tissues Organs. 2004;177(4):221-8 [15459478] Cancer Res. 1984 Aug;44(8):3174-7 [6430545] Cancer Res. 1988 May 15;48(10):2720-3 [3359433] Cancer Res. 1989 Apr 15;49(8):1904-8 [2495170] Int J Sports Med. 1990 Dec;11(6):413-20 [2286478] In Vivo. 1991 Jul-Aug;5(4):333-44 [1810418] Adv Exp Med Biol. 1992;322:203-22 [1442296] Adv Exp Med Biol. 1992;322:41-59 [1442300] In Vivo. 1993 Mar-Apr;7(2):151-8 [8364166] Carcinogenesis. 1995 Aug;16(8):1783-6 [7634404] Proc Assoc Am Physicians. 1995 Jul;107(2):181-6 [8624851] Carcinogenesis. 1997 May;18(5):1007-12 [9163688] Cancer Lett. 1997 Jun 24;116(2):151-8 [9215858] Cancer Res. 1997 Nov 1;57(21):4667-72 [9354418] Breast Cancer Res Treat. 1997 Nov-Dec;46(2-3):135-41 [9478269] J Natl Cancer Inst. 1999 Apr 7;91(7):629-34 [10203283] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-09-0034 ER - TY - JOUR T1 - Drug burden index score and functional decline in older people. AN - 734169509; 19958893 AB - The Drug Burden Index (DBI), a measure of exposure to anticholinergic and sedative medications, has been independently associated with physical and cognitive function in a cross-sectional analysis of community-dwelling older persons participating in the Health, Aging and Body Composition study. Here we evaluate the association between DBI and functional outcomes in Health, Aging and Body Composition study participants over 5 years. DBI was calculated at years 1 (baseline), 3, and 5, and a measure of the area under the curve for DBI (AUCDB) over the whole study period was devised and calculated. Physical performance was measured using the short physical performance battery, usual gait speed, and grip strength. The association of DBI at each time point and AUCDB with year 6 function was analyzed in data from participants with longitudinal functional measures, controlling for sociodemographics, comorbidities, and baseline function. Higher DBI at years 1, 3, and 5 was consistently associated with poorer function at year 6. On multivariate analysis, a 1-unit increase in AUCDB predicted decreases in short physical performance battery score of .08 (P=.01), gait speed of .01 m/s (P=.004), and grip strength of .27 kg (P=.004) at year 6. Increasing exposure to medication with anticholinergic and sedative effects, measured with DBI, is associated with lower objective physical function over 5 years in community-dwelling older people. JF - The American journal of medicine AU - Hilmer, Sarah N AU - Mager, Donald E AU - Simonsick, Eleanor M AU - Ling, Shari M AU - Windham, B Gwen AU - Harris, Tamara B AU - Shorr, Ronald I AU - Bauer, Douglas C AU - Abernethy, Darrell R AU - Health ABC Study AD - Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA. ; Health ABC Study Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1142 EP - 1149.e1-2 VL - 122 IS - 12 KW - Cholinergic Antagonists KW - 0 KW - Hypnotics and Sedatives KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test KW - Area Under Curve KW - Humans KW - Body Burden KW - Aged KW - Hypnotics and Sedatives -- adverse effects KW - Muscle Strength Dynamometer KW - Longitudinal Studies KW - Cholinergic Antagonists -- adverse effects KW - Male KW - Female KW - Multivariate Analysis KW - Drug-Related Side Effects and Adverse Reactions KW - Hand Strength KW - Gait -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734169509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Drug+burden+index+score+and+functional+decline+in+older+people.&rft.au=Hilmer%2C+Sarah+N%3BMager%2C+Donald+E%3BSimonsick%2C+Eleanor+M%3BLing%2C+Shari+M%3BWindham%2C+B+Gwen%3BHarris%2C+Tamara+B%3BShorr%2C+Ronald+I%3BBauer%2C+Douglas+C%3BAbernethy%2C+Darrell+R%3BHealth+ABC+Study&rft.aulast=Hilmer&rft.aufirst=Sarah&rft.date=2009-12-01&rft.volume=122&rft.issue=12&rft.spage=1142&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=1555-7162&rft_id=info:doi/10.1016%2Fj.amjmed.2009.02.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-18 N1 - Date created - 2009-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):72-7 [16456196] J Am Geriatr Soc. 2006 Feb;54(2):224-30 [16460372] J Am Geriatr Soc. 2006 May;54(5):743-9 [16696738] Am J Geriatr Cardiol. 2006 Nov-Dec;15(6):352-6 [17086027] Clin Pharmacol Ther. 2007 Feb;81(2):235-41 [17192773] Arch Intern Med. 2007 Apr 23;167(8):781-7 [17452540] Ann Intern Med. 2007 Jun 5;146(11):775-86 [17548409] Clin Pharmacol Ther. 2008 Mar;83(3):422-9 [17713474] N Engl J Med. 1999 Dec 30;341(27):2061-7 [10615079] J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M221-31 [10811152] J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56 [11253156] Arch Gen Psychiatry. 2003 Feb;60(2):198-203 [12578438] J Am Geriatr Soc. 2003 Nov;51(11):1563-70 [14687385] Mod Probl Pharmacopsychiatry. 1974;7(0):79-110 [4607278] Am J Epidemiol. 1977 Sep;106(3):203-14 [900119] Br J Clin Pharmacol. 1978 May;5(5):407-13 [656280] N Engl J Med. 1981 Mar 12;304(11):638-42 [7453741] J Clin Psychiatry. 1987 Aug;48(8):314-8 [3611032] Ann Intern Med. 1991 Jun 1;114(11):956-66 [2024864] Clin Geriatr Med. 1992 Feb;8(1):143-58 [1576572] N Engl J Med. 1995 Mar 2;332(9):556-61 [7838189] Age Ageing. 1995 Nov;24(6):468-73 [8588534] JAMA. 1999 Feb 10;281(6):558-60 [10022113] Age Ageing. 1999 May;28(3):283-8 [10475865] J Am Geriatr Soc. 1999 Jul;47(7):850-3 [10404930] J Clin Epidemiol. 2005 Jun;58(6):595-602 [15878473] Neuropsychopharmacology. 2005 Sep;30(9):1649-61 [15756305] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.amjmed.2009.02.021 ER - TY - JOUR T1 - Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice. AN - 734162370; 19760669 AB - High levels of insulin-like growth factor-1 (IGF-1) have been associated with a significant increase in colon cancer risk. Additionally, IGF-1 inhibits apoptosis and stimulates proliferation of colonic epithelial cells in vitro. Unfortunately, IGF-1 knockout mice have severe developmental abnormalities and most do not survive, making it difficult to study how genetic ablation of IGF-1 affects colon tumorigenesis. To test the hypothesis that inhibition of IGF-1 prevents colon tumorigenesis, we utilized a preexisting mouse model containing a deletion of the igf1 gene in the liver through a Cre/loxP system. These liver-specific IGF-1 deficient (LID) mice display a 50-75% reduction in circulating IGF-1 levels. We conducted a pilot study to assess the impact of liver-specific IGF-1 deficiency on azoxymethane (AOM)-induced colon tumors. LID mice had a significant inhibition of colon tumor multiplicity in the proximal area of the colon compared to their wild-type littermates. We examined markers of proliferation and apoptosis in the colons of the LID and wild-type mice to see if these were consistent with tumorigenesis. We observed a decrease in proliferation in the colons of the LID mice and an increase in apoptosis. Finally, we examined cytokine levels to determine whether IGF-1 interacts with inflammatory pathways to affect colon tumorigenesis. We observed a significant reduction in the levels of 7 out of 10 cytokines that were measured in the LID mice as compared to wild-type littermates. Results from this pilot study support the hypothesis that reductions in circulating IGF-1 levels may prevent colon tumorigenesis and affect both proliferation and apoptosis. Future experiments will investigate downstream genes of the IGF-1 receptor. JF - Molecular carcinogenesis AU - Olivo-Marston, Susan E AU - Hursting, Stephen D AU - Lavigne, Jackie AU - Perkins, Susan N AU - Maarouf, Rami S AU - Yakar, Shoshana AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1071 EP - 1076 VL - 48 IS - 12 KW - Carcinogens KW - 0 KW - insulin-like growth factor-1, mouse KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Integrases -- metabolism KW - Apoptosis KW - Liver -- metabolism KW - Mice KW - Mice, Transgenic KW - Cell Proliferation KW - Immunoenzyme Techniques KW - Mice, Knockout KW - Insulin-Like Growth Factor I -- physiology KW - Azoxymethane -- toxicity KW - Carcinogens -- toxicity KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734162370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Genetic+reduction+of+circulating+insulin-like+growth+factor-1+inhibits+azoxymethane-induced+colon+tumorigenesis+in+mice.&rft.au=Olivo-Marston%2C+Susan+E%3BHursting%2C+Stephen+D%3BLavigne%2C+Jackie%3BPerkins%2C+Susan+N%3BMaarouf%2C+Rami+S%3BYakar%2C+Shoshana%3BHarris%2C+Curtis+C&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2009-12-01&rft.volume=48&rft.issue=12&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 1999 Nov;140(11):5178-84 [10537147] Mol Endocrinol. 1998 Sep;12(9):1452-62 [9731712] Cancer Lett. 1998 Aug 14;130(1-2):29-34 [9751253] Comp Biochem Physiol B Biochem Mol Biol. 1998 Sep;121(1):19-26 [9972281] Apoptosis. 2005 May;10(3):525-35 [15909115] Carcinogenesis. 2005 Sep;26(9):1563-72 [15888492] Int J Cancer. 2008 Jan 15;122(2):472-6 [17918153] Cancer Res. 2008 May 15;68(10):3680-8 [18483250] World J Gastroenterol. 2008 Nov 21;14(43):6632-5 [19034964] Growth Horm IGF Res. 2000 Apr;10 Suppl A:S28-9 [10984282] Growth Horm IGF Res. 2000 Apr;10 Suppl A:S30-1 [10984283] Growth Horm IGF Res. 2000 Apr;10 Suppl A:S35-6 [10984286] Mol Pathol. 2001 Oct;54(5):311-6 [11577173] Carcinogenesis. 2001 Nov;22(11):1831-5 [11698346] Cancer Res. 2002 Feb 15;62(4):1030-5 [11861378] Int J Oncol. 2003 Jan;22(1):145-50 [12469197] J Gerontol A Biol Sci Med Sci. 2003 May;58(5):B400-5 [12730247] Cancer Res. 2003 Aug 1;63(15):4384-8 [12907608] Cell Struct Funct. 2003 Aug;28(4):255-63 [14586135] J Neurosci Res. 2004 Apr 1;76(1):98-103 [15048933] Environ Mol Mutagen. 2004;44(1):26-35 [15199544] Ann Intern Med. 1984 Nov;101(5):627-8 [6486593] Ann Intern Med. 1987 Apr;106(4):636-7 [3826970] Jpn J Cancer Res. 1989 Jan;80(1):51-8 [2540132] Dev Biol. 1991 Sep;147(1):239-50 [1879610] Gastroenterology. 1992 Apr;102(4 Pt 1):1101-8 [1312970] Cell. 1993 Oct 8;75(1):59-72 [8402901] Ann Intern Med. 1995 Jan 1;122(1):54-9 [7619109] BMJ. 1995 Jan 21;310(6973):170 [7833759] Endocr Rev. 1995 Feb;16(1):3-34 [7758431] Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):345-9 [10794477] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20577 ER - TY - JOUR T1 - Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. AN - 734156789; 19741151 AB - Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway, which is activated by genomic instability and DNA damage, leading to either cell death (apoptosis) or cell cycle arrest. Chk2 provides an unexplored therapeutic target against cancer cells. We recently reported 4,4'-diacetyldiphenylurea-bis(guanylhydrazone) (NSC 109555) as a novel chemotype Chk2 inhibitor. We have now synthesized a derivative of NSC 109555, PV1019 (NSC 744039) [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide], which is a selective submicromolar inhibitor of Chk2 in vitro. The cocrystal structure of PV1019 bound in the ATP binding pocket of Chk2 confirmed enzymatic/biochemical observations that PV1019 acts as a competitive inhibitor of Chk2 with respect to ATP. PV1019 was found to inhibit Chk2 in cells. It inhibits Chk2 autophosphorylation (which represents the cellular kinase activation of Chk2), Cdc25C phosphorylation, and HDMX degradation in response to DNA damage. PV1019 also protects normal mouse thymocytes against ionizing radiation-induced apoptosis, and it shows synergistic antiproliferative activity with topotecan, camptothecin, and radiation in human tumor cell lines. We also show that PV1019 and Chk2 small interfering RNAs can exert antiproliferative activity themselves in the cancer cells with high Chk2 expression in the NCI-60 screen. These data indicate that PV1019 is a potent and selective inhibitor of Chk2 with chemotherapeutic and radiosensitization potential. JF - The Journal of pharmacology and experimental therapeutics AU - Jobson, Andrew G AU - Lountos, George T AU - Lorenzi, Philip L AU - Llamas, Jenny AU - Connelly, John AU - Cerna, David AU - Tropea, Joseph E AU - Onda, Akikazu AU - Zoppoli, Gabriele AU - Kondapaka, Sudhir AU - Zhang, Guangtao AU - Caplen, Natasha J AU - Cardellina, John H AU - Yoo, Stephen S AU - Monks, Anne AU - Self, Christopher AU - Waugh, David S AU - Shoemaker, Robert H AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 816 EP - 826 VL - 331 IS - 3 KW - 7-nitro-1H-indole-2-carboxylic acid (4-(1-(guanidinohydrazone)ethyl)phenyl)amide KW - 0 KW - Antineoplastic Agents KW - Guanidines KW - Hydrazones KW - Protein Kinase Inhibitors KW - Radiation-Sensitizing Agents KW - Recombinant Proteins KW - Checkpoint Kinase 2 KW - EC 2.7.1.11 KW - CHEK2 protein, human KW - EC 2.7.11.1 KW - Chek2 protein, mouse KW - Protein-Serine-Threonine Kinases KW - cdc25 Phosphatases KW - EC 3.1.3.48 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Molecular Structure KW - Cell Proliferation -- drug effects KW - Animals KW - Recombinant Proteins -- biosynthesis KW - Cell Proliferation -- radiation effects KW - Models, Molecular KW - Dose-Response Relationship, Drug KW - DNA Damage KW - Humans KW - Apoptosis -- radiation effects KW - Catalytic Domain KW - Cell Culture Techniques KW - Mice KW - Cell Line, Tumor KW - cdc25 Phosphatases -- metabolism KW - Binding Sites KW - Blotting, Western KW - Phosphorylation KW - Cell Survival -- drug effects KW - Apoptosis -- drug effects KW - Flow Cytometry KW - Cell Survival -- radiation effects KW - Drug Synergism KW - Recombinant Proteins -- antagonists & inhibitors KW - Radiation-Sensitizing Agents -- chemistry KW - Camptothecin -- pharmacology KW - Protein Kinase Inhibitors -- pharmacology KW - Radiation-Sensitizing Agents -- pharmacology KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Hydrazones -- chemistry KW - Guanidines -- chemistry KW - Guanidines -- pharmacology KW - Protein-Serine-Threonine Kinases -- biosynthesis KW - Hydrazones -- pharmacology KW - Protein Kinase Inhibitors -- chemistry KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734156789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Cellular+inhibition+of+checkpoint+kinase+2+%28Chk2%29+and+potentiation+of+camptothecins+and+radiation+by+the+novel+Chk2+inhibitor+PV1019+%5B7-nitro-1H-indole-2-carboxylic+acid+%7B4-%5B1-%28guanidinohydrazone%29-ethyl%5D-phenyl%7D-amide%5D.&rft.au=Jobson%2C+Andrew+G%3BLountos%2C+George+T%3BLorenzi%2C+Philip+L%3BLlamas%2C+Jenny%3BConnelly%2C+John%3BCerna%2C+David%3BTropea%2C+Joseph+E%3BOnda%2C+Akikazu%3BZoppoli%2C+Gabriele%3BKondapaka%2C+Sudhir%3BZhang%2C+Guangtao%3BCaplen%2C+Natasha+J%3BCardellina%2C+John+H%3BYoo%2C+Stephen+S%3BMonks%2C+Anne%3BSelf%2C+Christopher%3BWaugh%2C+David+S%3BShoemaker%2C+Robert+H%3BPommier%2C+Yves&rft.aulast=Jobson&rft.aufirst=Andrew&rft.date=2009-12-01&rft.volume=331&rft.issue=3&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.109.154997 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2001 Sep 6;20(39):5503-10 [11571648] FEBS Lett. 2001 Sep 7;505(1):7-12 [11557032] Cancer Res. 2002 Oct 15;62(20):5743-8 [12384533] J Biol Chem. 2002 Dec 13;277(50):48418-26 [12386164] Science. 2002 Dec 6;298(5600):1912-34 [12471243] Drug Discov Today. 2002 Jun 1;7(11):601-11 [12047871] J Biol Chem. 2003 Sep 19;278(38):36163-8 [12855706] Oncogene. 2004 May 27;23(25):4353-61 [15048074] Bioorg Med Chem Lett. 2004 Aug 16;14(16):4319-21 [15261294] Adv Enzyme Regul. 1984;22:27-55 [6382953] Science. 1998 Dec 4;282(5395):1893-7 [9836640] Mol Biol Cell. 1999 Aug;10(8):2703-34 [10436023] Curr Med Chem. 1999 Sep;6(9):775-805 [10495352] J Med Chem. 2005 Mar 24;48(6):1873-85 [15771432] Nature. 2005 Apr 14;434(7035):864-70 [15829956] Nature. 2005 Apr 14;434(7035):907-13 [15829965] Nat Cell Biol. 2005 May;7(5):493-500 [15834407] Curr Pharm Des. 2005;11(22):2855-72 [16101442] Clin Cancer Res. 2006 May 1;12(9):2657-61 [16675556] EMBO J. 2006 Jul 12;25(13):3179-90 [16794575] Mol Cell Biol. 2006 Sep;26(18):6819-31 [16943424] Cancer Res. 2006 Dec 15;66(24):11576-9 [17178848] Bioorg Med Chem Lett. 2007 Jan 1;17(1):172-5 [17035018] Cell Cycle. 2007 Jan 1;6(1):104-10 [17245119] Mol Cancer Ther. 2007 Mar;6(3):935-44 [17363488] Mol Pharmacol. 2007 Oct;72(4):876-84 [17616632] Nat Rev Cancer. 2007 Dec;7(12):925-36 [18004398] Cell Death Differ. 2008 Mar;15(3):555-66 [18064041] Expert Opin Investig Drugs. 2008 Sep;17(9):1331-40 [18694366] Mol Cancer Ther. 2008 Sep;7(9):2955-66 [18790776] J Virol. 2008 Oct;82(19):9639-46 [18667510] Biochim Biophys Acta. 2008 Dec;1783(12):2223-33 [18804494] Mol Cell Biol. 2009 Jan;29(1):68-82 [18955500] Protein Sci. 2009 Jan;18(1):92-100 [19177354] J Biol Chem. 2009 Jul 3;284(27):18085-95 [19416980] Nat Rev Drug Discov. 2009 Jul;8(7):547-66 [19568282] Science. 2000 Mar 10;287(5459):1824-7 [10710310] Cancer Res. 2000 Nov 1;60(21):5934-6 [11085506] J Biol Chem. 2001 May 25;276(21):17914-9 [11279124] EMBO J. 2002 Oct 1;21(19):5195-205 [12356735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.109.154997 ER - TY - JOUR T1 - Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. AN - 734154062; 19773279 AB - Benzene is an established human haematotoxin, with substantial interindividual variation in benzene-induced toxicity. To further examine if genetic variation contributes to benzene haematotoxicity, we analysed 1023 tagSNPs in 121 gene regions important for benzene metabolism, haematopoiesis, leukaemia and lymphoma among 250 workers exposed to benzene and 140 unexposed controls in a cross-sectional study carried out in China. Linear regression was used to analyse the relationship between genetic polymorphisms and total white blood cell (WBC) count and its subtypes, adjusting for potential confounders and occupational exposure to benzene and toluene among exposed workers. The minp test assessed the association on the gene region level. The false discovery rate method was used to control for multiple comparisons. VEGF (minp = 0.0030) and ERCC3 (minp = 0.0042) were the most significantly associated gene regions with altered WBC counts among benzene-exposed workers, after accounting for multiple comparisons. Highly significant changes were also found for WBC subtype counts, including granulocytes, CD4+ T cells and lymphocytes for VEGF and granulocytes and NK cells for ERCC3. Further, in workers exposed to <1 ppm, a SNP in VEGF was associated with changes in WBC and granulocyte counts, and SNPs in ERCC3 were associated with changes in WBC, NK cell and granulocyte counts. Our findings suggest that genetic variation in VEGF, which plays an important role in blood vessel growth, and ERCC3, which is a member of the DNA repair pathway and is responsible for repairing bulky DNA adducts formed by chemicals, may contribute to individual susceptibility to benzene-induced haematotoxicity at relatively low levels of benzene exposure. JF - Occupational and environmental medicine AU - Hosgood, H D AU - Zhang, L AU - Shen, M AU - Berndt, S I AU - Vermeulen, R AU - Li, G AU - Yin, S AU - Yeager, M AU - Yuenger, J AU - Rothman, N AU - Chanock, S AU - Smith, M AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7240, USA. hosgoodd@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 848 EP - 853 VL - 66 IS - 12 KW - DNA-Binding Proteins KW - 0 KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - XPBC-ERCC-3 protein KW - 146045-44-5 KW - DNA Helicases KW - EC 3.6.4.- KW - Benzene KW - J64922108F KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Occupational Exposure -- adverse effects KW - Genetic Predisposition to Disease KW - Occupational Exposure -- analysis KW - Male KW - Leukocyte Count KW - Female KW - Leukocytes -- drug effects KW - Hematologic Diseases -- genetics KW - Hematologic Diseases -- chemically induced KW - Occupational Diseases -- genetics KW - Occupational Diseases -- blood KW - Hematologic Diseases -- blood KW - DNA-Binding Proteins -- genetics KW - DNA Helicases -- genetics KW - Benzene -- toxicity KW - Occupational Diseases -- chemically induced KW - Vascular Endothelial Growth Factor A -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734154062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Association+between+genetic+variants+in+VEGF%2C+ERCC3+and+occupational+benzene+haematotoxicity.&rft.au=Hosgood%2C+H+D%3BZhang%2C+L%3BShen%2C+M%3BBerndt%2C+S+I%3BVermeulen%2C+R%3BLi%2C+G%3BYin%2C+S%3BYeager%2C+M%3BYuenger%2C+J%3BRothman%2C+N%3BChanock%2C+S%3BSmith%2C+M%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2009-12-01&rft.volume=66&rft.issue=12&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.044024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-04 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 1989 Jul;82:31-5 [2792049] Biometrics. 1986 Mar;42(1):121-30 [3719049] Nature. 1995 Jul 6;376(6535):62-6 [7596435] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Int J Hematol. 1995 Dec;62(4):203-15 [8589366] Nature. 1996 Apr 4;380(6573):435-9 [8602241] Nature. 1996 Apr 4;380(6573):439-42 [8602242] Eur J Haematol Suppl. 1996;60:111-8 [8987252] Environ Health Perspect. 1996 Dec;104 Suppl 6:1247-50 [9118900] Mutat Res. 1997 Jan 3;373(1):113-23 [9015160] Endocr Rev. 1997 Feb;18(1):4-25 [9034784] Blood. 1997 Mar 15;89(6):1870-5 [9058706] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Blood. 1997 Oct 15;90(8):3167-72 [9376599] Toxicol Ind Health. 1997 Nov-Dec;13(6):661-714 [9399416] Cancer Res. 1998 May 15;58(10):2176-81 [9605763] J Biol Chem. 1998 Nov 13;273(46):30336-43 [9804796] Carcinogenesis. 1998 Nov;19(11):1955-61 [9855009] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):248-51 [16188086] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Hum Genet. 2006 Jul;119(6):659-68 [16738949] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jul;24(7):390-3 [16889696] Carcinogenesis. 2006 Oct;27(10):2083-9 [16728435] J Exp Med. 1990 Dec 1;172(6):1535-45 [2258694] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Nat Med. 2003 Jun;9(6):669-76 [12778165] J Mol Med (Berl). 2003 Jan;81(1):20-31 [12545246] Br J Haematol. 2002 Jul;118(1):151-6 [12100142] J Toxicol Environ Health A. 2000 Nov;61(5-6):357-72 [11086940] Blood. 2001 Mar 1;97(5):1427-34 [11222390] Carcinogenesis. 2009 Jan;30(1):50-8 [18978339] Cytokine. 2008 Aug;43(2):215-9 [18621544] Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-82 [18234850] Genet Epidemiol. 2007 Dec;31(8):803-12 [17549762] J Mol Cell Cardiol. 2007 Jan;42(1):142-9 [17070836] J Environ Monit. 2006 Nov;8(11):1143-8 [17075621] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Am J Ind Med. 2001 Aug;40(2):117-26 [11494338] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Nature. 2002 Jun 27;417(6892):954-8 [12087404] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.044024 ER - TY - JOUR T1 - Solution characterization of [methyl-(13)C]methionine HIV-1 reverse transcriptase by NMR spectroscopy. AN - 734150344; 19665484 AB - HIV reverse transcriptase (RT) is a primary target for drug intervention in the treatment of AIDS. We report the first solution NMR studies of [methyl-(13)C]methionine HIV-1 RT, aimed at better understanding the conformational and dynamic characteristics of RT, both in the presence and absence of the non-nucleoside RT inhibitor (NNRTI) nevirapine. The selection of methionine as a structural probe was based both on its favorable NMR characteristics, and on the presence of two important active site methionine residues, M184(66) and M230(66). Observation of the M184 resonance is subunit dependent; in the p66 subunit the solvent-exposed residue produces a readily observed signal with a characteristic resonance shift, while in the globular p51 subunit, the M184(51) resonance is shifted and broadened as M184 becomes buried in the protein interior. In contrast, although structural data indicates that the environment of M230 is also strongly subunit dependent, the M230 resonances from both subunits have very similar shift and relaxation characteristics. A comparison of chemical shift and intensity data with model-based predictions gives reasonable agreement for M184(66), while M230(66), located on the beta-hairpin "primer grip", is more mobile and solvent-exposed than suggested by crystal structures of the apo enzyme which have a "closed" fingers-thumb conformation. This mobility of the primer grip is presumably important for binding of non-nucleoside RT inhibitors (NNRTIs), since the NNRTI binding pocket is not observed in the absence of the inhibitors, requiring instead that the binding pocket be dynamically accessible. In the presence of the nevirapine, both the M184(66) and M230(66) resonances are significantly perturbed, while none of the methionine resonances in the p51 subunit is sensitive to this inhibitor. Site-directed mutagenesis indicates that both M16 and M357 produce two resonances in each subunit, and for both residues, the intensity ratio of the component peaks is strongly subunit dependent. Conformational features that might explain the multiple peaks are discussed. JF - Antiviral research AU - Zheng, Xunhai AU - Mueller, Geoffrey A AU - DeRose, Eugene F AU - London, Robert E AD - Laboratory of Molecular Biophysics, MR-01, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 205 EP - 214 VL - 84 IS - 3 KW - Carbon Isotopes KW - 0 KW - Reverse Transcriptase Inhibitors KW - Nevirapine KW - 99DK7FVK1H KW - Methionine KW - AE28F7PNPL KW - reverse transcriptase, Human immunodeficiency virus 1 KW - EC 2.7.7.- KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Index Medicus KW - Reverse Transcriptase Inhibitors -- chemistry KW - Mutagenesis, Site-Directed KW - Amino Acid Motifs KW - Carbon Isotopes -- metabolism KW - Nuclear Magnetic Resonance, Biomolecular KW - Carbon Isotopes -- chemistry KW - Catalytic Domain KW - Nevirapine -- chemistry KW - Molecular Conformation KW - Protein Binding KW - HIV Reverse Transcriptase -- genetics KW - HIV-1 -- metabolism KW - HIV-1 -- genetics KW - HIV-1 -- chemistry KW - HIV Reverse Transcriptase -- antagonists & inhibitors KW - Methionine -- metabolism KW - HIV Reverse Transcriptase -- metabolism KW - HIV-1 -- enzymology KW - HIV Reverse Transcriptase -- chemistry KW - Methionine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734150344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+research&rft.atitle=Solution+characterization+of+%5Bmethyl-%2813%29C%5Dmethionine+HIV-1+reverse+transcriptase+by+NMR+spectroscopy.&rft.au=Zheng%2C+Xunhai%3BMueller%2C+Geoffrey+A%3BDeRose%2C+Eugene+F%3BLondon%2C+Robert+E&rft.aulast=Zheng&rft.aufirst=Xunhai&rft.date=2009-12-01&rft.volume=84&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Antiviral+research&rft.issn=1872-9096&rft_id=info:doi/10.1016%2Fj.antiviral.2009.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-25 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7242-6 [7518928] J Mol Biol. 2009 May 8;388(3):644-58 [19324058] Methods Enzymol. 1989;177:44-73 [2691846] Proteins. 1991;9(2):99-107 [1755867] J Mol Biol. 2000 Aug 25;301(4):1029-39 [10966802] EMBO J. 2001 Mar 15;20(6):1449-61 [11250910] Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7188-93 [11416202] J Mol Biol. 2001 Sep 28;312(4):795-805 [11575933] Nucleic Acids Res. 2001 Dec 15;29(24):4963-72 [11812826] J Virol. 2002 Oct;76(19):10015-9 [12208978] J Biomol NMR. 2003 Jul;26(3):215-40 [12766419] Biophys J. 2003 Jun;84(6):3547-63 [12770866] Nucleic Acids Res. 2003 Jul 1;31(13):3316-9 [12824316] J Am Chem Soc. 2003 Aug 27;125(34):10420-8 [12926967] Biochemistry. 2003 Sep 30;42(38):11150-60 [14503865] Curr Opin Investig Drugs. 2003 Aug;4(8):966-73 [14508881] Protein Expr Purif. 2004 Mar;34(1):75-86 [14766302] J Biomol NMR. 2004 Jul;29(3):363-8 [15213434] Science. 1992 Jun 26;256(5065):1783-90 [1377403] Biochem Biophys Res Commun. 1993 Mar 31;191(3):1166-71 [7682061] J Biol Chem. 1993 Aug 5;268(22):16528-36 [7688366] Biochemistry. 1993 Nov 9;32(44):11810-8 [8218252] Protein Sci. 1994 Oct;3(10):1847-57 [7849600] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1222-6 [7532306] Science. 1995 Feb 17;267(5200):988-93 [7532321] Structure. 1994 Oct 15;2(10):953-61 [7532533] Nat Struct Biol. 1995 Apr;2(4):293-302 [7540934] Nat Struct Biol. 1995 Apr;2(4):303-8 [7540935] Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):8046-9 [7544013] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Protein Sci. 1995 Nov;4(11):2383-91 [8563636] Biochemistry. 1996 Jul 2;35(26):8553-62 [8679616] Structure. 1996 Jul 15;4(7):853-60 [8805568] J Biol Chem. 1997 May 16;272(20):13262-9 [9148945] Science. 1997 Jul 4;277(5322):112-6 [9204894] J Mol Biol. 1998 Dec 11;284(4):1095-111 [9837729] Eur J Biochem. 1999 Apr;261(1):10-8 [10103027] Protein Expr Purif. 2005 May;41(1):207-34 [15915565] Biochemistry. 2006 Mar 7;45(9):2779-89 [16503633] J Mol Biol. 2007 Jan 5;365(1):77-89 [17056061] J Mol Biol. 2007 Oct 19;373(2):282-95 [17822711] J Am Chem Soc. 2008 Aug 20;130(33):11097-105 [18652454] Nucleic Acids Res. 2008 Sep;36(15):5083-92 [18676450] J Med Chem. 2008 Dec 11;51(23):7449-58 [19007201] Biochemistry. 2004 Jul 20;43(28):8911-22 [15248749] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.antiviral.2009.07.021 ER - TY - JOUR T1 - Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. AN - 734142608; 19805409 AB - In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the model on the following: (1) data from quantitative high-throughput screening cytotoxicity and caspase activation assays conducted at the National Institutes of Health Chemical Genomics Center, (2) data from Salmonella typhimurium reverse mutagenicity assays conducted by the U.S. National Toxicology Program, and (3) hepatotoxicity data published in the Registry of Toxic Effects of Chemical Substances. Enrichments of structural features in toxic compounds are evaluated for their statistical significance and compiled into a simple additive model of toxicity and then used to score new compounds for potential toxicity. The predictive power of the model for cytotoxicity was validated using an independent set of compounds from the U.S. Environmental Protection Agency tested also at the National Institutes of Health Chemical Genomics Center. We compared the performance of our WFS approach with classical classification methods such as Naive Bayesian clustering and support vector machines. In most test cases, WFS showed similar or slightly better predictive power, especially in the prediction of hepatotoxic compounds, where WFS appeared to have the best performance among the three methods. The new algorithm has the important advantages of simplicity, power, interpretability, and ease of implementation. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Huang, Ruili AU - Southall, Noel AU - Xia, Menghang AU - Cho, Ming-Hsuang AU - Jadhav, Ajit AU - Nguyen, Dac-Trung AU - Inglese, James AU - Tice, Raymond R AU - Austin, Christopher P AD - Department of Health and Human Services, NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA. huangru@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 385 EP - 393 VL - 112 IS - 2 KW - Index Medicus KW - Mutagenicity Tests KW - Humans KW - Salmonella typhimurium -- genetics KW - Cell Line KW - Structure-Activity Relationship KW - Toxicity Tests KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734142608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Weighted+feature+significance%3A+a+simple%2C+interpretable+model+of+compound+toxicity+based+on+the+statistical+enrichment+of+structural+features.&rft.au=Huang%2C+Ruili%3BSouthall%2C+Noel%3BXia%2C+Menghang%3BCho%2C+Ming-Hsuang%3BJadhav%2C+Ajit%3BNguyen%2C+Dac-Trung%3BInglese%2C+James%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2009-12-01&rft.volume=112&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-25 N1 - Date created - 2009-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Inf Comput Sci. 2000 Jul-Aug;40(4):906-14 [10955517] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] J Med Chem. 2002 Sep 12;45(19):4350-8 [12213076] Nat Rev Drug Discov. 2003 Jul;2(7):542-53 [12815380] J Chem Inf Comput Sci. 2003 Jul-Aug;43(4):1192-9 [12870911] Chem Res Toxicol. 2004 Jan;17(1):3-16 [14727914] J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):704-15 [15032553] Nat Rev Drug Discov. 2004 Aug;3(8):711-5 [15286737] J Chem Inf Comput Sci. 1978 Aug;18(3):134-40 [681458] Mutat Res. 1991 May;257(3):229-306 [1707500] Hum Exp Toxicol. 1991 Jul;10(4):261-73 [1679649] Mutat Res. 1994 Feb 1;305(1):47-61 [7508547] Toxicol Lett. 1995 Sep;79(1-3):219-28 [7570659] Arch Biochem Biophys. 2005 Jan 15;433(2):369-78 [15581593] Curr Drug Metab. 2005 Jun;6(3):161-225 [15975040] Environ Health Perspect. 2005 Nov;113(11):1569-74 [16263513] Bioorg Med Chem. 2006 Apr 15;14(8):2779-88 [16377200] J Chem Inf Model. 2006 Mar-Apr;46(2):536-44 [16562981] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Chem Res Toxicol. 2006 Nov;19(11):1533-9 [17112242] Anal Biochem. 2007 Mar 15;362(2):221-8 [17266913] Chem Res Toxicol. 2007 Mar;20(3):344-69 [17302443] Mini Rev Med Chem. 2007 May;7(5):499-507 [17504185] Science. 2008 Feb 15;319(5865):906-7 [18276874] Chem Res Toxicol. 2008 Mar;21(3):659-67 [18281954] Environ Toxicol. 2001;16(6):543-9 [11769253] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp231 ER - TY - CONF T1 - Cancer immunotherapy and immunomonitoring (CITIM): redefining cancer therapy. AN - 734137668; 19908938 AB - The immune system is a critical element involved in the control of tumor development and progression. While we have learned how to manipulate the immune system to generate tumor-specific immune responses, cancer immunotherapy has not yet delivered substantial clinical benefits. It has become increasingly clear that tumor-induced abnormalities in the immune system not only hamper natural tumor immune surveillance, but also limit the effect of cancer immunotherapy. If the results of recent studies are of any indication, then we are on the verge of a real breakthrough in our understanding of the immunobiology of tumor-host interactions and of ways to manipulate it. This 1(st) International Conference on "Cancer Immunotherapy and Immunomonitoring (CITIM)" was the first meeting in Eastern Europe to specifically focus on the issue of immune regulation in the tumor environment, cancer immunotherapy, and immunomonitoring of immunotherapeutic clinical trials. This CITIM Conference held in Kiev, Ukraine, was comprised from eight plenary sessions and two special selected poster presentation sessions. Selected contributions from the participants of the Conference are presented in this issue of the Journal of Immunotoxicology. JF - Journal of immunotoxicology AU - Malyguine, Anatoli AU - Umansky, Victor AU - Shurin, Michael R Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 205 EP - 208 VL - 6 IS - 4 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, Neoplasm KW - Index Medicus KW - Monitoring, Immunologic KW - Humans KW - Ukraine KW - Clinical Trials as Topic KW - Antigens, Neoplasm -- immunology KW - Neoplasms -- therapy KW - Immune System -- immunology KW - Neoplasms -- immunology KW - Immunotherapy -- methods KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734137668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Cancer+immunotherapy+and+immunomonitoring+%28CITIM%29%3A+redefining+cancer+therapy.&rft.au=Malyguine%2C+Anatoli%3BUmansky%2C+Victor%3BShurin%2C+Michael+R&rft.aulast=Malyguine&rft.aufirst=Anatoli&rft.date=2009-12-01&rft.volume=6&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F15476910903120932 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-28 N1 - Date created - 2009-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/15476910903120932 ER - TY - JOUR T1 - Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. AN - 734132369; 19554018 AB - The precise contribution(s) of skin dendritic cells (DCs) to immune responses in the skin has not been well delineated. We developed an intradermal (i.d.) injection model in which CD8+ T (OT-I) cells that express ovalbumin (OVA) peptide-specific TCRs (Valpha2/Vbeta5) are delivered directly to the dermis of transgenic (Tg) mice expressing OVA in the epidermis. After i.d. injection, these mice reliably develop skin graft-versus-host disease (GVHD) by day 7. To determine the relative contribution of Langerhans cells (LCs) to the ensuing GVHD-like reaction, we generated K14-OVA x Langerin-diphtheria-toxin-receptor (Langerin-DTR) Tg mice to allow conditional ablation of LCs in the epidermis. To delineate the role of dermal DCs (dDCs) in the reaction, we also generated K14-OVA Tg chimeras using beta(2)-microglobulin-deficient (beta(2)m) congenic donor bone marrow cells. Dermal DCs in these mice cannot present OVA to autoreactive T cells (OT-I cells), whereas the LCs are antigen presentation-competent. Unexpectedly, OT-I cell injection into diphtheria toxin (DT)-treated beta(2)m --> K14-OVA x Langerin-DTR Tg mice resulted in skin GVHD. Thus, in vivo, both LC and dDC appear to be dispensable for the induction of keratinocyte-directed, CD8-mediated effector immune responses. Furthermore and surprisingly, OVA-expressing epidermal cells depleted of LCs that could not initiate allogeneic epidermal lymphocyte reactions activated naive OT-I cells in vitro. These results indicate that keratinocytes may function as accessory cells competent to prime naive skin-reactive T cells.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://network.nature.com/group/jidclub. JF - The Journal of investigative dermatology AU - Kim, Brian S AU - Miyagawa, Fumi AU - Cho, Young-Hun AU - Bennett, Clare L AU - Clausen, Björn E AU - Katz, Stephen I AD - Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 2805 EP - 2817 VL - 129 IS - 12 KW - Diphtheria Toxin KW - 0 KW - Ovalbumin KW - 9006-59-1 KW - Index Medicus KW - Ovalbumin -- immunology KW - Animals KW - Langerhans Cells -- drug effects KW - Dermis -- cytology KW - Mice KW - Mice, Transgenic KW - Dermis -- immunology KW - Antigen Presentation -- immunology KW - Langerhans Cells -- immunology KW - Adoptive Transfer KW - Mice, Inbred C57BL KW - Diphtheria Toxin -- pharmacology KW - Langerhans Cells -- cytology KW - Genes, MHC Class II -- immunology KW - Cell Line KW - Cell Communication -- immunology KW - Epidermis -- immunology KW - CD8-Positive T-Lymphocytes -- cytology KW - Graft vs Host Disease -- pathology KW - Graft vs Host Disease -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Epidermis -- cytology KW - Antigen-Presenting Cells -- cytology KW - Keratinocytes -- cytology KW - Antigen-Presenting Cells -- immunology KW - CD8-Positive T-Lymphocytes -- transplantation KW - Keratinocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734132369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Keratinocytes+function+as+accessory+cells+for+presentation+of+endogenous+antigen+expressed+in+the+epidermis.&rft.au=Kim%2C+Brian+S%3BMiyagawa%2C+Fumi%3BCho%2C+Young-Hun%3BBennett%2C+Clare+L%3BClausen%2C+Bj%C3%B6rn+E%3BKatz%2C+Stephen+I&rft.aulast=Kim&rft.aufirst=Brian&rft.date=2009-12-01&rft.volume=129&rft.issue=12&rft.spage=2805&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/10.1016%2Fj.chroma.2009.06.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-07 N1 - Date created - 2009-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2006 May 16;103(20):7783-8 [16672373] Nat Immunol. 2006 May;7(5):507-16 [16617337] J Invest Dermatol. 2008 Aug;128(8):1950-5 [18337832] J Exp Med. 2006 Nov 27;203(12):2627-38 [17116734] Int Immunol. 2001 May;13(5):695-704 [11312257] J Exp Med. 2001 Sep 17;194(6):769-79 [11560993] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):351-8 [11773639] Nat Immunol. 2002 Dec;3(12):1135-41 [12415265] J Exp Med. 2003 Jan 20;197(2):153-62 [12538655] Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3386-91 [12629221] Immunity. 2003 May;18(5):713-20 [12753747] Eur J Immunol. 2003 Jul;33(7):1879-88 [12811848] Science. 2003 Sep 26;301(5641):1925-8 [14512632] Nature. 2004 Jan 8;427(6970):154-9 [14712275] Nat Med. 2004 May;10(5):510-7 [15098028] Eur J Immunol. 2004 Jun;34(6):1542-50 [15162423] J Invest Dermatol. 2004 Jul;123(1):109-15 [15191550] Immunity. 2004 Sep;21(3):391-400 [15357950] Cell Immunol. 1976 Aug;25(2):137-51 [782728] J Invest Dermatol. 1980 Jul;75(1):61-7 [7391610] J Invest Dermatol. 1982 Jul;79(1):34-9 [6979588] J Immunol. 1983 Dec;131(6):2741-5 [6417231] J Invest Dermatol. 1986 Mar;86(3):226-34 [2427602] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7438-42 [3532113] J Exp Med. 1987 Dec 1;166(6):1654-67 [3119761] J Immunol. 1988 May 1;140(9):2956-63 [3129504] J Immunol. 1988 Oct 1;141(7):2216-20 [2459202] J Clin Invest. 1989 Feb;83(2):490-6 [2464000] Science. 1990 Jun 8;248(4960):1227-30 [2112266] Eur J Immunol. 1990 Sep;20(9):1893-7 [2120067] J Immunol. 1993 Mar 15;150(6):2148-59 [8450207] Immunology. 1997 Nov;92(3):388-95 [9486113] Nature. 1998 Mar 19;392(6673):245-52 [9521319] Immunology. 1998 Jun;94(2):135-41 [9741333] J Leukoc Biol. 1999 Sep;66(3):462-70 [10496317] Trends Immunol. 2004 Dec;25(12):655-8 [15530835] Immunity. 2005 May;22(5):643-54 [15894281] J Cell Biol. 2005 May 23;169(4):569-76 [15897263] Immunity. 2005 Dec;23(6):611-20 [16356859] Immunity. 2006 Feb;24(2):191-201 [16473831] Comment In: J Invest Dermatol. 2009 Dec;129(12):2740 [19901942] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jid.2009.176 ER - TY - JOUR T1 - Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. AN - 734128371; 19857969 AB - The important and diverse biological functions of adrenergic receptors, a subclass of G protein-coupled receptors (GPCRs), have made the search for compounds that selectively stimulate or inhibit the activity of different adrenergic receptor subtypes an important area of medicinal chemistry. We previously synthesized 2-, 5-, and 6-fluoronorepinehprine (FNE) and 2-, 5-, and 6-fluoroepinephrine (FEPI) and found that 2FNE and 2FEPI were selective beta-adrenergic agonists and that 6FNE and 6FEPI were selective alpha-adrenergic agonists, while 5FNE and 5FEPI were unselective. Agonist potencies correlated well with receptor binding affinities. Here, through a combination of molecular modeling and site-directed mutagenesis, we have identified N293 in the beta(2)-adrenergic receptor as a crucial residue for the selectivity of the receptor for catecholamines fluorinated at different positions. JF - Bioorganic & medicinal chemistry AU - Pooput, Chaya AU - Rosemond, Erica AU - Karpiak, Joel AU - Deflorian, Francesca AU - Vilar, Santiago AU - Costanzi, Stefano AU - Wess, Jürgen AU - Kirk, Kenneth L AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2009/12/01/ PY - 2009 DA - 2009 Dec 01 SP - 7987 EP - 7992 VL - 17 IS - 23 KW - Receptors, Adrenergic, beta-2 KW - 0 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Kinetics KW - Humans KW - Binding, Competitive -- physiology KW - Substrate Specificity KW - Structure-Activity Relationship KW - Point Mutation -- physiology KW - Epinephrine -- analogs & derivatives KW - Norepinephrine -- pharmacology KW - Epinephrine -- pharmacology KW - Norepinephrine -- analogs & derivatives KW - Receptors, Adrenergic, beta-2 -- genetics KW - Receptors, Adrenergic, beta-2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734128371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Structural+basis+of+the+selectivity+of+the+beta%282%29-adrenergic+receptor+for+fluorinated+catecholamines.&rft.au=Pooput%2C+Chaya%3BRosemond%2C+Erica%3BKarpiak%2C+Joel%3BDeflorian%2C+Francesca%3BVilar%2C+Santiago%3BCostanzi%2C+Stefano%3BWess%2C+J%C3%BCrgen%3BKirk%2C+Kenneth+L&rft.aulast=Pooput&rft.aufirst=Chaya&rft.date=2009-12-01&rft.volume=17&rft.issue=23&rft.spage=7987&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/10.1016%2Fj.bmc.2009.10.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-12 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2007 Nov 23;318(5854):1258-65 [17962520] J Med Chem. 2008 May 22;51(10):2907-14 [18442228] J Med Chem. 2008 Aug 28;51(16):4978-85 [18680279] J Comput Chem. 2010 Mar;31(4):707-20 [19569204] J Biol Chem. 2004 Jan 2;279(1):686-91 [14559905] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2736-41 [14981238] Chembiochem. 2004 May 3;5(5):666-75 [15122639] Science. 1979 Jun 15;204(4398):1217-9 [221978] J Med Chem. 1979 Dec;22(12):1493-7 [231654] Life Sci. 1980 Oct 27;27(17):1577-85 [6255279] Med Res Rev. 1984 Apr-Jun;4(2):189-220 [6144824] J Med Chem. 1986 Oct;29(10):1982-8 [3020250] Trends Pharmacol Sci. 1988 Oct;9(10):356-61 [2855960] J Med Chem. 1991 Mar;34(3):1063-8 [1672155] Pharmacol Rev. 1994 Jun;46(2):121-36 [7938162] Annu Rev Biochem. 1994;63:101-32 [7979235] Br J Pharmacol. 1999 Sep;128(2):272-4 [10510435] J Med Chem. 2006 Mar 9;49(5):1706-19 [16509586] Nat Chem Biol. 2006 Aug;2(8):417-22 [16799554] Trends Pharmacol Sci. 2007 Aug;28(8):397-406 [17629961] Science. 2007 Nov 23;318(5854):1266-73 [17962519] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmc.2009.10.015 ER - TY - JOUR T1 - Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. AN - 734096435; 19725928 AB - Because melanomas are intrinsically resistant to conventional radiotherapy and chemotherapy, many alternative treatment approaches have been developed such as biochemotherapy and immunotherapy. The most common cause of multidrug resistance (MDR) in human cancers is the expression and function of one or more ATP-binding cassette (ABC) transporters that efflux anticancer drugs from cells. Melanoma cells express a group of ABC transporters (such as ABCA9, ABCB1, ABCB5, ABCB8, ABCC1, ABCC2, and ABCD1) that may be associated with the resistance of melanoma cells to a broad range of anticancer drugs and/or of melanocytes to toxic melanin intermediates and metabolites. In this review, we propose a model (termed the ABC-M model) in which the intrinsic MDR of melanoma cells is at least in part because of the transporter systems that may also play a critical role in reducing the cytotoxicity of the melanogenic pathway in melanocytes. The ABC-M model suggests molecular strategies to reverse MDR function in the context of the melanogenic pathway, which could open therapeutic avenues towards the ultimate goal of circumventing clinical MDR in patients with melanoma. JF - Pigment cell & melanoma research AU - Chen, Kevin G AU - Valencia, Julio C AU - Gillet, Jean-Pierre AU - Hearing, Vincent J AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 740 EP - 749 VL - 22 IS - 6 KW - Antineoplastic Agents KW - 0 KW - Melanins KW - P-Glycoprotein KW - Index Medicus KW - Melanocytes -- physiology KW - P-Glycoprotein -- metabolism KW - Melanosomes -- metabolism KW - Humans KW - Antineoplastic Agents -- metabolism KW - Neoplasm Metastasis KW - Melanocytes -- cytology KW - Antineoplastic Agents -- therapeutic use KW - Models, Biological KW - Neoplastic Stem Cells -- metabolism KW - Melanins -- biosynthesis KW - Melanoma -- pathology KW - Drug Resistance, Multiple -- physiology KW - ATP-Binding Cassette Transporters -- metabolism KW - Melanoma -- drug therapy KW - ATP-Binding Cassette Transporters -- genetics KW - Drug Resistance, Neoplasm -- physiology KW - Melanoma -- physiopathology KW - Melanoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734096435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+%26+melanoma+research&rft.atitle=Involvement+of+ABC+transporters+in+melanogenesis+and+the+development+of+multidrug+resistance+of+melanoma.&rft.au=Chen%2C+Kevin+G%3BValencia%2C+Julio+C%3BGillet%2C+Jean-Pierre%3BHearing%2C+Vincent+J%3BGottesman%2C+Michael+M&rft.aulast=Chen&rft.aufirst=Kevin&rft.date=2009-12-01&rft.volume=22&rft.issue=6&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+%26+melanoma+research&rft.issn=1755-148X&rft_id=info:doi/10.1111%2Fj.1755-148X.2009.00630.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-17 N1 - Date created - 2009-10-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2003 Nov 21;278(47):47156-65 [12960149] J Natl Cancer Inst. 2009 Sep 16;101(18):1259-71 [19704071] Cancer Res. 2004 Jun 15;64(12):4294-301 [15205344] Exp Cell Res. 2004 Aug 15;298(2):317-28 [15265682] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] N Engl J Med. 2004 Sep 2;351(10):998-1012 [15342808] J Natl Cancer Inst. 1989 Jan 18;81(2):116-24 [2562856] Arch Dermatol. 1989 Apr;125(4):524-7 [2539058] Cancer Res. 1990 Mar 15;50(6):1779-85 [1968359] J Cancer Res Clin Oncol. 1991;117(2):168-71 [1672531] J Invest Dermatol. 1995 Jul;105(1):3-7 [7615972] Br J Ophthalmol. 1996 Nov;80(11):1009-12 [8976731] Cancer Chemother Pharmacol. 1997;40 Suppl:S13-9 [9272128] Int J Cancer. 1998 Mar 16;75(6):885-93 [9506534] Hum Pathol. 1998 Jun;29(6):594-8 [9635679] Anticancer Res. 1998 Nov-Dec;18(6A):4101-4 [9891452] J Clin Oncol. 1999 Mar;17(3):968-75 [10071291] J Natl Cancer Inst. 2004 Nov 17;96(22):1702-13 [15547183] J Dermatol Sci. 2005 Jan;37(1):3-14 [15619429] Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):756-67 [15701866] Biotechniques. 2005 Feb;38(2):198, 200, 202, 204 [15727125] Melanoma Res. 1999 Oct;9(5):433-43 [10596909] Oncogene. 2000 Jan 20;19(3):395-402 [10656687] Melanoma Res. 2000 Oct;10(5):499-505 [11095412] J Cell Biol. 2001 Feb 19;152(4):809-24 [11266471] Cancer Metastasis Rev. 2001;20(1-2):27-32 [11831643] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Mol Biol Cell. 2002 Jun;13(6):1953-64 [12058062] J Invest Dermatol. 2002 Jun;118(6):923-32 [12060385] Mol Biol Cell. 2002 Dec;13(12):4206-20 [12475946] Clin Chem. 2003 Feb;49(2):230-8 [12560344] Cell Struct Funct. 2002 Dec;27(6):443-56 [12576637] Oncogene. 2003 May 19;22(20):3138-51 [12789290] Int J Oncol. 2003 Jul;23(1):213-20 [12792796] J Invest Dermatol. 2003 Jul;121(1):172-6 [12839578] Pigment Cell Res. 2003 Oct;16(5):504-8 [12950728] Cancer Res. 2003 Sep 15;63(18):5909-16 [14522917] Oncogene. 2003 Oct 20;22(47):7340-58 [14576842] Pigment Cell Res. 2005 Apr;18(2):102-12 [15760339] Int J Cancer. 2005 Jun 20;115(3):393-402 [15688364] Cancer Res. 2005 May 15;65(10):4320-33 [15899824] Br J Cancer. 2005 Jul 25;93(2):216-23 [15999103] Annu Rev Genomics Hum Genet. 2005;6:123-42 [16124856] Mol Cancer Ther. 2005 Oct;4(10):1595-604 [16227410] Cancer Res. 2005 Oct 15;65(20):9328-37 [16230395] FEBS Lett. 2006 Feb 13;580(4):998-1009 [16405967] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] J Cell Sci. 2006 Mar 15;119(Pt 6):1080-91 [16492709] Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3452-8 [16740770] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9903-7 [16777967] J Clin Oncol. 2006 Jul 1;24(19):3157-63 [16809738] Physiol Rev. 2006 Jul;86(3):849-99 [16816140] Genes Dev. 2006 Aug 15;20(16):2149-82 [16912270] Cell. 2007 Mar 9;128(5):853-64 [17350573] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] Nature. 2008 Jan 17;451(7176):345-9 [18202660] J Clin Oncol. 2008 Jun 10;26(17):2890-4 [18539969] Nature. 2008 Dec 4;456(7222):593-8 [19052619] Mol Cancer Res. 2009 Jan;7(1):79-87 [19147539] Cancer Res. 2009 Feb 1;69(3):992-9 [19155314] Curr Opin Immunol. 2009 Apr;21(2):233-40 [19304471] J Biol Chem. 2004 Jan 2;279(1):288-98 [14576150] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1755-148X.2009.00630.x ER - TY - JOUR T1 - Identification of prenatal amphetamines exposure by maternal interview and meconium toxicology in the Infant Development, Environment and Lifestyle (IDEAL) study. AN - 733785709; 19935364 AB - The Infant Development Environment and Lifestyle study is investigating the effects of prenatal methamphetamine (MAMP) exposure on infant and child development; potential concurrent exposure to cannabis and tobacco also are evaluated. Maternal self-reported drug use and/or meconium toxicology results defined drug exposure status. It is unclear how the frequency, duration, and magnitude of maternal MAMP exposure affect qualitative and quantitative meconium results. Interviews regarding maternal drug use were collected shortly after birth; meconium specimens were screened for amphetamines, cannabis, and cotinine by immunoassay and confirmed by gas chromatography mass spectrometry. The majority of MAMP- and cannabis-exposed infants were identified by maternal interview alone. Meconium tests were more likely to be positive if the mother reported MAMP and cannabis use, particularly in the third trimester. Less than half of immunoassay-positive amphetamines (31.0%) and cannabis (17.9%) meconium results were confirmed by gas chromatography mass spectrometry. Tobacco exposure was equally detected by immunoassay cotinine screening and maternal report. Meconium concentrations did not correlate with maternal self-report status or trimester of use or frequency or route of MAMP use. Maternal self-report was more sensitive than meconium testing for identifying MAMP and cannabis-exposed neonates; however, the timing of drug exposure may influence meconium toxicology results. Most women stopped MAMP and cannabis use before the third trimester. In the first trimester, meconium has not yet formed, and based on our recent results for opiates and cocaine, drug use in the second trimester appears to be poorly reflected in meconium. Low confirmation rates in meconium reinforce the need for confirmatory testing following positive screening results and additional research to identify alternative biomarkers. JF - Therapeutic drug monitoring AU - Gray, Teresa R AU - LaGasse, Linda L AU - Smith, Lynne M AU - Derauf, Chris AU - Grant, Penny AU - Shah, Rizwan AU - Arria, Amelia M AU - Della Grotta, Sheri A AU - Strauss, Arthur AU - Haning, William F AU - Lester, Barry M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 769 EP - 775 VL - 31 IS - 6 KW - Amphetamines KW - 0 KW - Cannabinoids KW - Neurotoxins KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Sensitivity and Specificity KW - Cotinine -- analysis KW - Young Adult KW - Humans KW - Infant, Newborn KW - Marijuana Smoking KW - Cannabinoids -- analysis KW - Pregnancy KW - Smoking KW - Adult KW - Interviews as Topic KW - Pregnancy Trimesters KW - Adolescent KW - Female KW - Male KW - Self Disclosure KW - Meconium -- chemistry KW - Neurotoxins -- analysis KW - Amphetamines -- analysis KW - Substance Abuse Detection -- methods KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733785709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Identification+of+prenatal+amphetamines+exposure+by+maternal+interview+and+meconium+toxicology+in+the+Infant+Development%2C+Environment+and+Lifestyle+%28IDEAL%29+study.&rft.au=Gray%2C+Teresa+R%3BLaGasse%2C+Linda+L%3BSmith%2C+Lynne+M%3BDerauf%2C+Chris%3BGrant%2C+Penny%3BShah%2C+Rizwan%3BArria%2C+Amelia+M%3BDella+Grotta%2C+Sheri+A%3BStrauss%2C+Arthur%3BHaning%2C+William+F%3BLester%2C+Barry+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2009-12-01&rft.volume=31&rft.issue=6&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=1536-3694&rft_id=info:doi/10.1097%2FFTD.0b013e3181bb438e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-19 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatrics. 2001 Feb;107(2):309-17 [11158464] Ther Drug Monit. 2009 Feb;31(1):70-5 [19125148] Dev Pharmacol Ther. 1992;19(4):183-90 [1343621] Arch Pathol Lab Med. 1994 Oct;118(10):988-93 [7944901] J Anal Toxicol. 1994 Sep;18(5):294-5 [7990450] Clin Chem. 1995 Nov;41(11):1614-6 [7586551] J Anal Toxicol. 1999 Oct;23(6):436-45 [10517548] Forensic Sci Int. 2005 Oct 4;153(1):59-65 [15923097] Int J Toxicol. 2006 May-Jun;25(3):143-63 [16717031] Matern Child Health J. 2006 May;10(3):293-302 [16395620] Pediatrics. 2006 Sep;118(3):1149-56 [16951010] Anal Bioanal Chem. 2007 Aug;388(7):1455-65 [17370066] Acta Paediatr. 2007 Dec;96(12):1734-7 [17953730] Neurotoxicol Teratol. 2008 Jan-Feb;30(1):20-8 [18031987] Clin Pharmacol Ther. 2008 Nov;84(5):604-12 [18701886] Clin Chem. 2008 Dec;54(12):2018-27 [18845770] Neurotoxicol Teratol. 1991 Sep-Oct;13(5):535-40 [1758408] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FTD.0b013e3181bb438e ER - TY - JOUR T1 - Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype. AN - 733687761; 20049202 AB - Breast cancer has recently been linked to cadmium exposure. Although not uniformly supported, it is hypothesized that cadmium acts as a metalloestrogenic carcinogen via the estrogen receptor (ER). Thus, we studied the effects of chronic exposure to cadmium on the normal human breast epithelial cell line MCF-10A, which is ER-negative but can convert to ER-positive during malignant transformation. Cells were continuously exposed to low-level cadmium (2.5 muM) and checked in vitro and by xenograft study for signs of malignant transformation. Transformant cells were molecularly characterized by protein and transcript analysis of key genes in breast cancer. Over 40 weeks of cadmium exposure, cells showed increasing secretion of matrix metalloproteinase-9, loss of contact inhibition, increased colony formation, and increasing invasion, all typical for cancer cells. Inoculation of cadmium-treated cells into mice produced invasive, metastatic anaplastic carcinoma with myoepithelial components. These cadmium-transformed breast epithelial (CTBE) cells displayed characteristics of basal-like breast carcinoma, including ER-alpha negativity and HER2 (human epidermal growth factor receptor 2) negativity, reduced expression of BRCA1 (breast cancer susceptibility gene 1), and increased CK5 (cytokeratin 5) and p63 expression. CK5 and p63, both breast stem cell markers, were prominently overexpressed in CTBE cell mounds, indicative of persistent proliferation. CTBE cells showed global DNA hypomethylation and c-myc and k-ras overexpression, typical in aggressive breast cancers. CTBE cell xenograft tumors were also ER-alpha negative. Cadmium malignantly transforms normal human breast epithelial cells-through a mechanism not requiring ER-alpha-into a basal-like cancer phenotype. Direct cadmium induction of a malignant phenotype in human breast epithelial cells strongly fortifies a potential role in breast cancer. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Dill, Anna L AU - Coppin, Jean-François AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute (NCI) at National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1847 EP - 1852 VL - 117 IS - 12 KW - CKAP4 protein, human KW - 0 KW - Estrogen Receptor alpha KW - Keratin-5 KW - Membrane Proteins KW - Cadmium KW - 00BH33GNGH KW - Aromatase KW - EC 1.14.14.1 KW - Index Medicus KW - malignant transformation KW - breast cancer KW - basal-type KW - cadmium KW - estrogen receptor KW - Phenotype KW - Animals KW - Aromatase -- metabolism KW - Humans KW - Estrogen Receptor alpha -- analysis KW - Mice KW - Cell Line, Tumor KW - Membrane Proteins -- analysis KW - Keratin-5 -- analysis KW - Female KW - Cadmium -- toxicity KW - Breast Neoplasms -- chemically induced KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733687761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cadmium+malignantly+transforms+normal+human+breast+epithelial+cells+into+a+basal-like+phenotype.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BTokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BDill%2C+Anna+L%3BCoppin%2C+Jean-Fran%C3%A7ois%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2009-12-01&rft.volume=117&rft.issue=12&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900999 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-10 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2000 Apr;14(4):545-53 [10770491] Mod Pathol. 2007 Jul;20(7):711-21 [17464311] Biol Reprod. 2000 Jul;63(1):259-66 [10859267] J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):3-15 [12160084] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Nat Med. 2003 Aug;9(8):1081-4 [12858169] Cell Prolif. 2003 Oct;36 Suppl 1:73-84 [14521517] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421] Breast Cancer Res Treat. 2004 Apr;84(3):273-88 [15026625] Adv Anat Pathol. 2007 Sep;14(5):358-73 [17717437] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1680-5 [18230721] Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):108-12 [18227734] Medicina (Kaunas). 2008;44(6):415-20 [18660635] Cancer Res. 2008 Aug 1;68(15):6435-41 [18676869] J Mammary Gland Biol Neoplasia. 2004 Jan;9(1):27-37 [15082916] Pathol Oncol Res. 2004;10(2):74-9 [15188022] Cancer Res. 2004 Jul 1;64(13):4585-92 [15231670] Oncogene. 2004 Jul 29;23(34):5792-8 [15122325] Cancer Res. 2004 Oct 1;64(19):7078-85 [15466203] Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] J Biol Chem. 1994 Jun 17;269(24):16896-901 [8207012] IARC Monogr Eval Carcinog Risks Hum. 1993;58:119-237 [8022055] Sci Total Environ. 1996 Jul 30;186(3):251-6 [8677430] Int J Oncol. 1998 Nov;13(5):907-15 [9772278] Breast Cancer Res. 2004;6(6):229-39 [15535852] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Przegl Lek. 2004;61(7):786-8 [15792022] Anticancer Res. 2005 Jan-Feb;25(1A):369-75 [15816560] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Clin Exp Metastasis. 2005;22(3):275-84 [16158255] Histopathology. 2005 Nov;47(5):458-66 [16241993] Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 [16488983] Nature. 2006 Feb 23;439(7079):993-7 [16395311] J Appl Toxicol. 2006 May-Jun;26(3):191-7 [16489580] J Natl Cancer Inst. 2006 Jun 21;98(12):869-73 [16788160] Toxicol Appl Pharmacol. 2006 Oct 1;216(1):20-8 [16716372] Trends Mol Med. 2006 Nov;12(11):537-44 [17011236] Stem Cell Rev. 2005;1(3):207-13 [17142857] J Biol Chem. 2007 Feb 16;282(7):4243-52 [17130135] Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:36-9 [16804515] Comment In: Environ Health Perspect. 2009 Dec;117(12):A552 [20049192] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900999 ER - TY - JOUR T1 - Toxicity of organic fluorophores used in molecular imaging: literature review. AN - 733677027; 20003892 AB - Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be investigated before they can be administered safely to patients. A review of published literature on the toxicity of 19 widely used fluorophores was conducted by searching 26 comprehensive biomedical and chemical literature databases and analyzing the retrieved material. These fluorophores included Alexa Fluor 488 and 514, BODIPY FL, BODIPY R6G, Cy 5.5, Cy 7, cypate, fluorescein, indocyanine green, Oregon green, 8-phenyl BODIPY, rhodamine 110, rhodamine 6G, rhodamine X, rhodol, TAMRA, Texas red, and Tokyo green. Information regarding cytotoxicity, tissue toxicity, in vivo toxicity, and mutagenicity was included. Considerable toxicity-related information was available for the Food and Drug Administration (FDA)-approved compounds indocyanine green and fluorescein, but published information on many of the non-FDA-approved fluorophores was limited. The information located was encouraging because the amounts of fluorophore used in molecular imaging probes are typically much lower than the toxic doses described in the literature. Ultimately, the most effective and appropriate probes for use in patients will be determined by their fluorescent characteristics and the safety of the conjugates. JF - Molecular imaging AU - Alford, Raphael AU - Simpson, Haley M AU - Duberman, Josh AU - Hill, G Craig AU - Ogawa, Mikako AU - Regino, Celeste AU - Kobayashi, Hisataka AU - Choyke, Peter L AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, and NIH Library, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 341 EP - 354 VL - 8 IS - 6 KW - Fluorescent Dyes KW - 0 KW - Rhodamines KW - rhodamine 6G KW - 037VRW83CF KW - Indocyanine Green KW - IX6J1063HV KW - Fluorescein KW - TPY09G7XIR KW - Index Medicus KW - Animals KW - Indocyanine Green -- toxicity KW - Humans KW - Rhodamines -- toxicity KW - Fluorescein -- toxicity KW - Diagnostic Imaging -- methods KW - Fluorescent Dyes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733677027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+imaging&rft.atitle=Toxicity+of+organic+fluorophores+used+in+molecular+imaging%3A+literature+review.&rft.au=Alford%2C+Raphael%3BSimpson%2C+Haley+M%3BDuberman%2C+Josh%3BHill%2C+G+Craig%3BOgawa%2C+Mikako%3BRegino%2C+Celeste%3BKobayashi%2C+Hisataka%3BChoyke%2C+Peter+L&rft.aulast=Alford&rft.aufirst=Raphael&rft.date=2009-12-01&rft.volume=8&rft.issue=6&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Molecular+imaging&rft.issn=1536-0121&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-08 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized trial and pharmacokinetic study of pegfilgrastim versus filgrastim after dose-intensive chemotherapy in young adults and children with sarcomas. AN - 733675716; 19920107 AB - To compare the effectiveness, tolerance, and pharmacokinetics of a single dose of pegfilgrastim to daily filgrastim in children and young adults with sarcomas treated with dose-intensive combination chemotherapy. Patients were randomized to receive a single dose of 100 mcg/kg of pegfilgrastim s.c. or 5 mcg/kg/day of filgrastim s.c., daily until neutrophil recovery after two treatment cycles with vincristine, doxorubicin, and cyclophosphamide (VDC) and two cycles of etoposide and ifosfamide (IE). The duration of severe neutropenia (absolute neutrophil count, < or =500/mcL) during cycles 1 to 4 and cycle duration for all cycles were compared. Pharmacokinetics of pegfilgrastim and filgrastim and CD34+ stem cell mobilization were studied on cycle 1. Growth factor-related toxicity, transfusions, and episodes of fever and neutropenia and infections were collected for cycles 1 to 4. Thirty-four patients (median age, 20 years; range 3.8-25.8) were enrolled, and 32 completed cycles 1 to 4. The median (range) duration of absolute neutrophil count of <500/mcL was 5.5 (3-8) days for pegfilgrastim and 6 (0-9) days for filgrastim (P = 0.76) after VDC, and 1.5 (0-4) days for pegfilgrastim and 3.75 (0-6.5) days for filgrastim (P = 0.11) after IE. More episodes of febrile neutropenia and documented infections occurred on the filgrastim arm. Serum pegfilgrastim concentrations were highly variable. Pegfilgrastim apparent clearance (11 mL/h/kg) was similar to that reported in adults. A single dose per cycle of pegfilgrastim was well tolerated and may be as effective as daily filgrastim based on the duration of severe neutropenia and number of episodes of febrile neutropenia and documented infections after dose-intensive treatment with VDC and IE. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Fox, Elizabeth AU - Widemann, Brigitte C AU - Hawkins, Douglas S AU - Jayaprakash, Nalini AU - Dagher, Ramzi AU - Aikin, Alberta A AU - Bernstein, Donna AU - Long, Lauren AU - Mackall, Crystal AU - Helman, Lee AU - Steinberg, Seth M AU - Balis, Frank M AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. foxb@mail.nih.gov Y1 - 2009/12/01/ PY - 2009 DA - 2009 Dec 01 SP - 7361 EP - 7367 VL - 15 IS - 23 SN - 1078-0432, 1078-0432 KW - Antigens, CD34 KW - 0 KW - Recombinant Proteins KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - pegfilgrastim KW - 3A58010674 KW - Filgrastim KW - PVI5M0M1GW KW - Index Medicus KW - Neutrophils -- metabolism KW - Young Adult KW - Humans KW - Adult KW - Antigens, CD34 -- biosynthesis KW - Child KW - Neutropenia -- drug therapy KW - Adolescent KW - Time Factors KW - Child, Preschool KW - Drug Administration Schedule KW - Sarcoma -- drug therapy KW - Granulocyte Colony-Stimulating Factor -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733675716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Randomized+trial+and+pharmacokinetic+study+of+pegfilgrastim+versus+filgrastim+after+dose-intensive+chemotherapy+in+young+adults+and+children+with+sarcomas.&rft.au=Fox%2C+Elizabeth%3BWidemann%2C+Brigitte+C%3BHawkins%2C+Douglas+S%3BJayaprakash%2C+Nalini%3BDagher%2C+Ramzi%3BAikin%2C+Alberta+A%3BBernstein%2C+Donna%3BLong%2C+Lauren%3BMackall%2C+Crystal%3BHelman%2C+Lee%3BSteinberg%2C+Seth+M%3BBalis%2C+Frank+M&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2009-12-01&rft.volume=15&rft.issue=23&rft.spage=7361&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0761 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-08 N1 - Date created - 2009-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pediatr Hematol Oncol. 2005 Nov;27(11):627-9 [16282899] J Pediatr Hematol Oncol. 2005 Aug;27(8):449-51 [16096530] J Clin Oncol. 2006 Jul 1;24(19):3187-205 [16682719] J Clin Pharmacol. 2006 Jul;46(7):747-57 [16809800] Anticancer Drugs. 2007 Mar;18(3):277-81 [17264759] Curr Opin Oncol. 2007 Jul;19(4):328-35 [17545795] Curr Med Res Opin. 2007 Sep;23(9):2283-95 [17697451] J Pediatr Hematol Oncol. 2000 May-Jun;22(3):227-41 [10864054] J Clin Oncol. 2000 Jul;18(13):2522-8 [10893282] J Clin Oncol. 2002 Feb 1;20(3):727-31 [11821454] Ann Oncol. 2003 Jan;14(1):29-35 [12488289] Curr Hematol Rep. 2002 Nov;1(2):95-102 [12901130] Pharmacotherapy. 2003 Aug;23(8 Pt 2):9S-14S [12921217] J Pharm Sci. 2004 May;93(5):1367-73 [15067712] Curr Pharm Des. 2004;10(11):1235-44 [15078138] J Clin Oncol. 2004 Aug 15;22(16):3350-6 [15310780] J Clin Oncol. 1996 Feb;14(2):362-72 [8636745] Cancer. 1996 Aug 15;78(4):901-11 [8756388] J Clin Oncol. 2005 Feb 20;23(6):1178-84 [15718314] Transfusion. 2006 Feb;46(2):180-5 [16441592] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0761 ER - TY - JOUR T1 - Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. AN - 733620360; 19959685 AB - Exposure to secondhand smoke during adulthood has detrimental health effects, including increased lung cancer risk. Compared with adults, children may be more susceptible to secondhand smoke. This susceptibility may be exacerbated by alterations in inherited genetic variants of innate immunity genes. We hypothesized a positive association between childhood secondhand smoke exposure and lung cancer risk that would be modified by genetic polymorphisms in the mannose binding lectin-2 (MBL2) gene resulting in well-known functional changes in innate immunity. Childhood secondhand smoke exposure and lung cancer risk was assessed among men and women in the ongoing National Cancer Institute-Maryland Lung Cancer (NCI-MD) study, which included 624 cases and 348 controls. Secondhand smoke history was collected via in-person interviews. DNA was used for genotyping the MBL2 gene. To replicate, we used an independent case-control study from Mayo Clinic consisting of 461 never smokers, made up of 172 cases and 289 controls. All statistical tests were two-sided. In the NCI-MD study, secondhand smoke exposure during childhood was associated with increased lung cancer risk among never smokers [odds ratio (OR), 2.25; 95% confidence interval (95% CI), 1.04-4.90]. This was confirmed in the Mayo study (OR, 1.47; 95% CI, 1.00-2.15). A functional MBL2 haplotype associated with high circulating levels of MBL and increased MBL2 activity was associated with increased lung cancer risk among those exposed to childhood secondhand smoke in both the NCI-MD and Mayo studies (OR, 2.52; 95% CI, 1.13-5.60, and OR, 2.78; 95% CI, 1.18-3.85, respectively). Secondhand smoke exposure during childhood is associated with increased lung cancer risk among never smokers, particularly among those possessing a haplotype corresponding to a known overactive complement pathway of the innate immune system. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Olivo-Marston, Susan E AU - Yang, Ping AU - Mechanic, Leah E AU - Bowman, Elise D AU - Pine, Sharon R AU - Loffredo, Christopher A AU - Alberg, Anthony J AU - Caporaso, Neil AU - Shields, Peter G AU - Chanock, Stephen AU - Wu, Yanhong AU - Jiang, Ruoxiang AU - Cunningham, Julie AU - Jen, Jin AU - Harris, Curtis C AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD 20892-4258, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 3375 EP - 3383 VL - 18 IS - 12 KW - MBL2 protein, human KW - 0 KW - Mannose-Binding Lectin KW - Tobacco Smoke Pollution KW - Index Medicus KW - Humans KW - Aged KW - Child KW - Genotype KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Environmental Exposure KW - Middle Aged KW - Genetic Predisposition to Disease KW - Adolescent KW - Female KW - Male KW - Lung Neoplasms -- etiology KW - Polymorphism, Genetic -- genetics KW - Tobacco Smoke Pollution -- adverse effects KW - Mannose-Binding Lectin -- genetics KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733620360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Childhood+exposure+to+secondhand+smoke+and+functional+mannose+binding+lectin+polymorphisms+are+associated+with+increased+lung+cancer+risk.&rft.au=Olivo-Marston%2C+Susan+E%3BYang%2C+Ping%3BMechanic%2C+Leah+E%3BBowman%2C+Elise+D%3BPine%2C+Sharon+R%3BLoffredo%2C+Christopher+A%3BAlberg%2C+Anthony+J%3BCaporaso%2C+Neil%3BShields%2C+Peter+G%3BChanock%2C+Stephen%3BWu%2C+Yanhong%3BJiang%2C+Ruoxiang%3BCunningham%2C+Julie%3BJen%2C+Jin%3BHarris%2C+Curtis+C&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2009-12-01&rft.volume=18&rft.issue=12&rft.spage=3375&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-09-0986 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-23 N1 - Date created - 2009-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2008 Sep 17;100(18):1278 [18780860] Arch Intern Med. 2008 May 26;168(10):1097-103 [18504338] J Biochem. 1999 Dec;126(6):1004-12 [10578050] Environ Health Perspect. 2000 Jan;108(1):73-82 [10620527] Int J Epidemiol. 2000 Apr;29(2):224-31 [10817117] Genes Immun. 2001 Dec;2(8):442-50 [11781711] Toxicol Lett. 2002 Feb 28;127(1-3):111-9 [12052648] Carcinogenesis. 2003 Feb;24(2):269-74 [12584177] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Mol Immunol. 2003 Sep;40(2-4):73-84 [12914814] Mol Immunol. 2003 Nov;40(7):423-9 [14568388] J Leukoc Biol. 2004 May;75(5):805-14 [14761934] Carcinogenesis. 2004 Oct;25(10):1935-44 [15192016] Am J Public Health. 1972 Jun;62(6):807-13 [5032007] Cancer Res. 1986 Sep;46(9):4804-7 [3731126] Am J Public Health. 1992 Nov;82(11):1525-30 [1443304] Addict Behav. 1993 Nov-Dec;18(6):601-21 [8178700] J Clin Epidemiol. 1994 Apr;47(4):339-49; discussion 351-3 [7730859] J Immunol. 1995 Sep 15;155(6):3013-20 [7673719] Environ Health Perspect. 1995 Sep;103 Suppl 6:7-12 [8549494] Stat Methods Med Res. 1998 Jun;7(2):119-36 [9654638] Cancer Epidemiol Biomarkers Prev. 1999 May;8(5):461-5 [10350443] Diabetologia. 2005 Jan;48(1):198-202 [15616805] BMJ. 2005 Feb 5;330(7486):277 [15681570] Pediatr Allergy Immunol. 2005 May;16(3):231-5 [15853952] Scand J Immunol. 2005 May;61(5):466-74 [15882439] Intern Med J. 2005 Sep;35(9):548-55 [16105157] J Allergy Clin Immunol. 2005 Dec;116(6):1381-3 [16337475] Mutat Res. 2006 Jan;612(1):14-39 [16027031] Clin Exp Immunol. 2006 Mar;143(3):414-9 [16487239] Int J Cancer. 2006 Oct 15;119(8):1970-5 [16721783] Tissue Antigens. 2006 Sep;68(3):193-209 [16948640] Mol Immunol. 2007 Jan;44(1-3):33-43 [16908067] Arthritis Rheum. 2007 Jan;56(1):21-9 [17195187] J Clin Oncol. 2007 Feb 10;25(5):469-71 [17290053] J Clin Oncol. 2007 Feb 10;25(5):561-70 [17290066] J Natl Cancer Inst. 2007 Sep 19;99(18):1401-9 [17848669] Genes Immun. 2006 Mar;7(2):85-94 [16395391] Arch Otolaryngol Head Neck Surg. 2006 May;132(5):482-6 [16702562] J Leukoc Biol. 2006 Jul;80(1):107-16 [16617157] Curr Allergy Asthma Rep. 2006 Sep;6(5):377-83 [16899199] Pediatr Allergy Immunol. 2007 Dec;18(8):665-70 [17651383] Pediatr Allergy Immunol. 2009 May;20(3):219-26 [18700861] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-0986 ER - TY - JOUR T1 - Protonation of individual histidine residues is not required for the pH-dependent entry of west nile virus: evaluation of the "histidine switch" hypothesis. AN - 733131052; 19776132 AB - Histidine residues have been hypothesized to function as sensors of environmental pH that can trigger the activity of viral fusion proteins. We investigated a requirement for histidine residues in the envelope (E) protein of West Nile virus during pH-dependent entry into cells. Each histidine was individually replaced with a nonionizable amino acid and tested functionally. In each instance, mutants capable of orchestrating pH-dependent infection were identified. These results do not support a requirement for any single histidine as a pH-sensing "switch," and they suggest that additional features of the E protein are involved in triggering pH-dependent steps in the flavivirus life cycle. JF - Journal of virology AU - Nelson, Steevenson AU - Poddar, Subhajit AU - Lin, Tsai-Yu AU - Pierson, Theodore C AD - Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 12631 EP - 12635 VL - 83 IS - 23 KW - Viral Envelope Proteins KW - 0 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Histidine KW - 4QD397987E KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Amino Acid Substitution -- genetics KW - Hydrogen-Ion Concentration KW - Humans KW - Genes, Reporter KW - Protein Structure, Tertiary KW - Cell Line KW - West Nile virus -- physiology KW - Histidine -- genetics KW - Virus Internalization KW - Viral Envelope Proteins -- metabolism KW - Histidine -- metabolism KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733131052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Protonation+of+individual+histidine+residues+is+not+required+for+the+pH-dependent+entry+of+west+nile+virus%3A+evaluation+of+the+%22histidine+switch%22+hypothesis.&rft.au=Nelson%2C+Steevenson%3BPoddar%2C+Subhajit%3BLin%2C+Tsai-Yu%3BPierson%2C+Theodore+C&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2009-12-01&rft.volume=83&rft.issue=23&rft.spage=12631&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01072-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 2000 Mar 30;269(1):37-46 [10725196] J Virol. 2009 Jul;83(13):6494-507 [19386704] Cell. 2002 Mar 8;108(5):717-25 [11893341] J Biol Chem. 2003 Apr 18;278(16):13789-94 [12571240] J Virol. 2003 Jul;77(14):7856-62 [12829825] EMBO J. 2004 Feb 25;23(4):728-38 [14963486] J Gen Virol. 1984 Aug;65 ( Pt 8):1261-72 [6086817] J Gen Virol. 1985 Sep;66 ( Pt 9):1969-82 [4031825] J Gen Virol. 1986 Jan;67 ( Pt 1):157-66 [3944582] J Gen Virol. 1990 Aug;71 ( Pt 8):1845-50 [2167941] Virology. 1993 May;194(1):219-23 [8480420] J Virol. 2004 Dec;78(24):13543-52 [15564465] Nat Rev Microbiol. 2005 Jan;3(1):13-22 [15608696] J Neurovirol. 2005 Oct;11(5):469-75 [16287688] J Virol. 2006 Feb;80(3):1290-301 [16415006] Virology. 2006 Mar 1;346(1):53-65 [16325883] Protein Sci. 2006 May;15(5):1214-8 [16597822] J Gen Virol. 2006 Oct;87(Pt 10):2755-66 [16963734] Structure. 2006 Oct;14(10):1481-7 [17027497] J Virol. 2006 Nov;80(22):11000-8 [16943291] J Virol. 2006 Dec;80(23):11467-74 [16987985] J Virol. 2007 May;81(9):4881-5 [17301152] J Virol. 2007 Nov;81(21):12019-28 [17728239] Cell Host Microbe. 2007 Apr 19;1(2):135-45 [18005691] Virology. 2008 Jan 20;370(2):403-14 [17936324] Biochem Soc Trans. 2008 Feb;36(Pt 1):43-5 [18208382] PLoS Pathog. 2008 May;4(5):e1000060 [18464894] Nat Struct Mol Biol. 2008 Jul;15(7):690-8 [18596815] Nat Struct Mol Biol. 2008 Oct;15(10):1024-30 [18776902] J Cell Biol. 2008 Oct 20;183(2):353-61 [18936253] Virology. 2008 Nov 10;381(1):67-74 [18801552] PLoS Pathog. 2008 Dec;4(12):e1000244 [19096510] J Virol. 2009 May;83(9):4670-7 [19244325] Mol Cell. 2001 Mar;7(3):593-602 [11463384] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01072-09 ER - TY - JOUR T1 - Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions. AN - 733130941; 19759158 AB - Although human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been extensively studied, there are still significant questions about the effects of mutations on the maturation and stability of RT. We show here that a significant fraction (>80%) of the single point mutations we generated in the thumb subdomain of HIV-1 (RT) affect the stability of RT in virions. Fragments of the unstable mutant RTs can be detected in Western blots of virion proteins; however, the degree of degradation varies. The titers of the mutants whose virions contain degraded RTs are reduced. Some, but not all, of the unstable RT thumb subdomain mutants we analyzed have a temperature-sensitive phenotype. A preliminary survey of mutations in other subdomains of RT shows that some of these mutations also destabilize RT. The stability of the RT mutants is enhanced by the addition of a protease inhibitor, suggesting that the viral protease plays an important role in the degradation of the mutant RTs. These results confirm and extend earlier reports of mutations that affect the stability of RT in virions. The data suggest that the stability of a mutant RT in virions could be a major factor in determining the virus titer and, by extension, viral fitness, which could affect whether a mutation in RT is acceptable to the virus. JF - Journal of virology AU - Dunn, Linda L AU - McWilliams, Mary Jane AU - Das, Kalyan AU - Arnold, Eddy AU - Hughes, Stephen H AD - HIV-Drug Resistance Program, NCI-Frederick, Frederick, Maryland 21701-1201, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 12336 EP - 12344 VL - 83 IS - 23 KW - Mutant Proteins KW - 0 KW - reverse transcriptase, Human immunodeficiency virus 1 KW - EC 2.7.7.- KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - HIV Protease KW - EC 3.4.23.- KW - p16 protease, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Protein Stability KW - Mutant Proteins -- metabolism KW - Humans KW - Point Mutation KW - Protein Structure, Tertiary KW - HIV Reverse Transcriptase -- genetics KW - HIV-1 -- genetics KW - HIV Reverse Transcriptase -- metabolism KW - HIV Protease -- metabolism KW - Mutation, Missense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733130941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Halofuginone+mediated+protection+against+radiation-induced+leg+contracture.&rft.au=Ishii%2C+Hisanari%3BChoudhuri%2C+Rajani%3BMathias%2C+Askale%3BSowers%2C+Anastasia+L%3BFlanders%2C+Kathleen+C%3BCook%2C+John+A%3BMitchell%2C+James+B&rft.aulast=Ishii&rft.aufirst=Hisanari&rft.date=2009-08-01&rft.volume=35&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2008 Apr 4;283(14):9196-205 [18218634] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71 [18230722] EMBO J. 2001 Mar 15;20(6):1449-61 [11250910] J Virol. 2001 Jul;75(14):6537-46 [11413321] J Virol. 2001 Oct;75(19):9357-66 [11533199] J Virol. 2003 Jan;77(2):1512-23 [12502865] Proc Natl Acad Sci U S A. 1974 Dec;71(12):4732-6 [4531013] Virology. 1990 Apr;175(2):456-64 [1691562] Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10895-9 [1720554] Protein Sci. 1993 Dec;2(12):2167-76 [7507754] J Mol Biol. 1994 Oct 28;243(3):472-83 [7525967] Methods Cell Biol. 1994;43 Pt A:99-112 [7823872] Antimicrob Agents Chemother. 1995 Jul;39(7):1624-8 [7492119] Proteins. 1996 Jan;24(1):51-72 [8628733] Biochemistry. 1997 Aug 19;36(33):10292-300 [9254628] Methods. 1997 Aug;12(4):337-42 [9245614] Antimicrob Agents Chemother. 1997 Nov;41(11):2484-91 [9371354] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):638-45 [9435245] J Virol. 1998 Mar;72(3):2047-54 [9499059] J Mol Biol. 1998 Apr 3;277(3):559-72 [9533880] Science. 1998 Nov 27;282(5394):1669-75 [9831551] J Virol. 1999 Oct;73(10):8448-56 [10482597] J Virol. 2005 Aug;79(16):10247-57 [16051818] J Virol. 2005 Sep;79(18):11952-61 [16140771] J Infect Dis. 2005 Nov 1;192(9):1537-44 [16206068] J Virol. 2006 Aug;80(16):7939-51 [16873251] J Virol. 2007 Jul;81(14):7463-75 [17494082] J Mol Biol. 2007 Sep 14;372(2):369-81 [17651754] Nucleic Acids Res. 2009 Mar;37(4):1193-201 [19129221] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00676-09 ER - TY - JOUR T1 - Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. AN - 733129996; 19910029 AB - Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders defined by persistent blood eosinophilia > or =1.5 x 10(9)/L, absence of a secondary cause, and evidence of eosinophil-associated pathology. With the exception of a recent multicenter trial of mepolizumab (anti-IL-5 mAb), published therapeutic experience has been restricted to case reports and small case series. The purpose of the study was to collect and summarize baseline demographic, clinical, and laboratory characteristics in a large, diverse cohort of patients with HES and to review responses to treatment with conventional and novel therapies. Clinical and laboratory data from 188 patients with HES, seen between January 2001 and December 2006 at 11 institutions in the United States and Europe, were collected retrospectively by chart review. Eighteen of 161 patients (11%) tested were Fip1-like 1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA) mutation-positive, and 29 of 168 patients tested (17%) had a demonstrable aberrant or clonal T-cell population. Corticosteroid monotherapy induced complete or partial responses at 1 month in 85% (120/141) of patients with most remaining on maintenance doses (median, 10 mg prednisone equivalent daily for 2 months to 20 years). Hydroxyurea and IFN-alpha (used in 64 and 46 patients, respectively) were also effective, but their use was limited by toxicity. Imatinib (used in 68 patients) was more effective in patients with the FIP1L1-PDGFRA mutation (88%) than in those without (23%; P < .001). This study, the largest clinical analysis of patients with HES to date, not only provides useful information for clinicians but also should stimulate prospective trials to optimize treatment of HES. JF - The Journal of allergy and clinical immunology AU - Ogbogu, Princess U AU - Bochner, Bruce S AU - Butterfield, Joseph H AU - Gleich, Gerald J AU - Huss-Marp, Johannes AU - Kahn, Jean Emmanuel AU - Leiferman, Kristin M AU - Nutman, Thomas B AU - Pfab, Florian AU - Ring, Johannes AU - Rothenberg, Marc E AU - Roufosse, Florence AU - Sajous, Marie-Helene AU - Sheikh, Javed AU - Simon, Dagmar AU - Simon, Hans-Uwe AU - Stein, Miguel L AU - Wardlaw, Andrew AU - Weller, Peter F AU - Klion, Amy D AD - National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA. aklion@nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1319 EP - 25.e3 VL - 124 IS - 6 KW - Adrenal Cortex Hormones KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Benzamides KW - CCL17 protein, human KW - Chemokine CCL17 KW - IL5 protein, human KW - Interferon-alpha KW - Interleukin-5 KW - Oncogene Proteins, Fusion KW - Piperazines KW - Pyrimidines KW - mRNA Cleavage and Polyadenylation Factors KW - mepolizumab KW - reslizumab KW - 35A26E427H KW - Cyclosporine KW - 83HN0GTJ6D KW - Imatinib Mesylate KW - 8A1O1M485B KW - FIP1L1-PDGFRA fusion protein, human KW - EC 2.7.10.1 KW - Receptor, Platelet-Derived Growth Factor alpha KW - Tryptases KW - EC 3.4.21.59 KW - Hydroxyurea KW - X6Q56QN5QC KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Chemokine CCL17 -- blood KW - Pyrimidines -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Humans KW - Tryptases -- blood KW - Retrospective Studies KW - Aged KW - Child KW - Pyrimidines -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Cyclosporine -- administration & dosage KW - Aged, 80 and over KW - Adrenal Cortex Hormones -- administration & dosage KW - Adult KW - Adolescent KW - Interleukin-5 -- blood KW - Hydroxyurea -- administration & dosage KW - Male KW - Interferon-alpha -- therapeutic use KW - Piperazines -- therapeutic use KW - Cyclosporine -- therapeutic use KW - Hydroxyurea -- therapeutic use KW - Piperazines -- administration & dosage KW - Antibodies, Monoclonal -- administration & dosage KW - Drug Therapy, Combination KW - Adrenal Cortex Hormones -- therapeutic use KW - Middle Aged KW - Female KW - Oncogene Proteins, Fusion -- immunology KW - mRNA Cleavage and Polyadenylation Factors -- immunology KW - Hypereosinophilic Syndrome -- immunology KW - Receptor, Platelet-Derived Growth Factor alpha -- metabolism KW - Hypereosinophilic Syndrome -- drug therapy KW - Eosinophils -- drug effects KW - Eosinophils -- metabolism KW - mRNA Cleavage and Polyadenylation Factors -- metabolism KW - Oncogene Proteins, Fusion -- metabolism KW - Receptor, Platelet-Derived Growth Factor alpha -- immunology KW - Hypereosinophilic Syndrome -- metabolism KW - Eosinophils -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733129996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Hypereosinophilic+syndrome%3A+a+multicenter%2C+retrospective+analysis+of+clinical+characteristics+and+response+to+therapy.&rft.au=Ogbogu%2C+Princess+U%3BBochner%2C+Bruce+S%3BButterfield%2C+Joseph+H%3BGleich%2C+Gerald+J%3BHuss-Marp%2C+Johannes%3BKahn%2C+Jean+Emmanuel%3BLeiferman%2C+Kristin+M%3BNutman%2C+Thomas+B%3BPfab%2C+Florian%3BRing%2C+Johannes%3BRothenberg%2C+Marc+E%3BRoufosse%2C+Florence%3BSajous%2C+Marie-Helene%3BSheikh%2C+Javed%3BSimon%2C+Dagmar%3BSimon%2C+Hans-Uwe%3BStein%2C+Miguel+L%3BWardlaw%2C+Andrew%3BWeller%2C+Peter+F%3BKlion%2C+Amy+D&rft.aulast=Ogbogu&rft.aufirst=Princess&rft.date=2009-12-01&rft.volume=124&rft.issue=6&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2009.09.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-12 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Allergy Clin Immunol. 2002 Sep;110(3):476-9 [12209097] N Engl J Med. 2003 Mar 27;348(13):1201-14 [12660384] Blood. 2003 Jun 15;101(12):4660-6 [12676775] Blood. 2004 Apr 15;103(8):2939-41 [15070668] Medicine (Baltimore). 1975 Jan;54(1):1-27 [1090795] Arch Intern Med. 1978 Aug;138(8):1244-6 [677979] Blood. 1994 May 15;83(10):2759-79 [8180373] N Engl J Med. 1999 Oct 7;341(15):1112-20 [10511609] Blood. 2004 Nov 15;104(10):3038-45 [15284118] Leukemia. 2005 May;19(5):792-8 [15772698] J Allergy Clin Immunol. 2006 Jun;117(6):1292-302 [16750989] Leuk Res. 2007 May;31(5):691-4 [17095087] Immunol Allergy Clin North Am. 2007 Aug;27(3):389-413 [17868856] Immunol Allergy Clin North Am. 2007 Aug;27(3):519-27 [17868862] N Engl J Med. 2008 Mar 20;358(12):1215-28 [18344568] J Allergy Clin Immunol. 2008 Apr;121(4):1054-6 [18234315] J Allergy Clin Immunol. 2008 Jun;121(6):1473-83, 1483.e1-4 [18410960] Comment In: J Allergy Clin Immunol. 2010 Jun;125(6):1399-1401.e2 [20392489] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2009.09.022 ER - TY - JOUR T1 - Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors. AN - 67657413; 19430790 AB - Temozolomide pharmacokinetics were evaluated in children receiving concurrent O(6)-benzylguanine (O(6)BG), which enhanced the hematological toxicity of temozolomide. Temozolomide was administered orally, daily for 5 days starting at 28 mg/m(2) per day with escalations to 40, 55, 75 and 100 mg/m(2) per day with O(6)BG intravenously daily for 5 days at doses of 60, 90 or 120 mg/m(2) per day. Plasma samples were drawn over 48 h after the day 5 dose. Temozolomide was quantified with a validated HPLC/tandem mass spectroscopic assay. Temozolomide was rapidly absorbed (mean T (max), 2.1 h). The mean apparent clearance (CL/F) (96 mL/min/m(2)) was similar to the CL/F for temozolomide alone and was not age- or gender-dependent. There was minimal inter-patient variability. The enhanced hematologic toxicity resulting from combining O(6)BG with temozolomide does not appear to be the result of a pharmacokinetic interaction between the agents. JF - Cancer chemotherapy and pharmacology AU - Meany, Holly J AU - Warren, Katherine E AU - Fox, Elizabeth AU - Cole, Diane E AU - Aikin, Alberta A AU - Balis, Frank M AD - Pediatric Oncology Branch, National Cancer Institute, 10 Center Drive, Bldg. 10 CRC/Rm. 1-5750, Bethesda, MD 20892, USA. hmeany@cnmc.org Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 137 EP - 142 VL - 65 IS - 1 KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Guanine KW - 5Z93L87A1R KW - Dacarbazine KW - 7GR28W0FJI KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Young Adult KW - Age Factors KW - Drug Interactions KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Humans KW - Tandem Mass Spectrometry -- methods KW - Child KW - Guanine -- administration & dosage KW - Child, Preschool KW - Dacarbazine -- analogs & derivatives KW - Chromatography, High Pressure Liquid -- methods KW - Dacarbazine -- administration & dosage KW - Guanine -- analogs & derivatives KW - Adolescent KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Hematologic Diseases -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacokinetics+of+temozolomide+administered+in+combination+with+O6-benzylguanine+in+children+and+adolescents+with+refractory+solid+tumors.&rft.au=Meany%2C+Holly+J%3BWarren%2C+Katherine+E%3BFox%2C+Elizabeth%3BCole%2C+Diane+E%3BAikin%2C+Alberta+A%3BBalis%2C+Frank+M&rft.aulast=Meany&rft.aufirst=Holly&rft.date=2009-12-01&rft.volume=65&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1015-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1015-8 ER - TY - JOUR T1 - Veteran Parents in Child Protective Services: Theory and Implementation AN - 61363790; 201001636 AB - 'Veteran parents' (VPs), or parents who have experienced challenges concerning their children's health and then mentor other families through similar situations, are widely used for parent support. This model has been adopted by Child Protective Services (CPS) to increase parent engagement. Here, we expand the theoretical discussion of VPs in CPS to address the unique challenges and implementation issues associated with maltreating families. We contend that this model, as originally evaluated in pediatrics, is compromised within CPS. VP programs in CPS will require the same rigorous investigation as other new programs. Adapted from the source document. JF - Family Relations AU - Nilsen, Wendy J AU - Affronti, Melissa L AU - Coombes, Margaret L AD - University of Rochester School of Medicine and Dentistry nilsenwj@od.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 520 EP - 535 PB - Wiley Publishing, Malden MA VL - 58 IS - 5 SN - 0197-6664, 0197-6664 KW - child abuse/neglect child protective services family stress parent advocate parent education and support programs veteran parent KW - Veterans KW - Pediatrics KW - Child Welfare Services KW - Family KW - Children KW - Parents KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61363790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Relations&rft.atitle=Veteran+Parents+in+Child+Protective+Services%3A+Theory+and+Implementation&rft.au=Nilsen%2C+Wendy+J%3BAffronti%2C+Melissa+L%3BCoombes%2C+Margaret+L&rft.aulast=Nilsen&rft.aufirst=Wendy&rft.date=2009-12-01&rft.volume=58&rft.issue=5&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Family+Relations&rft.issn=01976664&rft_id=info:doi/10.1111%2Fj.1741-3729.2009.00572.x LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 76 N1 - Last updated - 2016-09-28 N1 - CODEN - FAREDL N1 - SubjectsTermNotLitGenreText - Child Welfare Services; Parents; Family; Veterans; Pediatrics; Children DO - http://dx.doi.org/10.1111/j.1741-3729.2009.00572.x ER - TY - JOUR T1 - Bioethics Inside the Beltway: What is Affordable Health Insurance? The Reasonable Tradeoff Account of Affordability AN - 58847852; 2010-483793 AB - The reform of the health care system will include a mandate: Individuals are required to purchase health insurance provided that affordable options are available. But what is affordable health insurance? Three accounts of affordability of health coverage have been advanced. The first two accounts are empirical. The third account is needs-based. All three accounts are inadequate. I propose a fourth, the reasonable tradeoff account, according to which individuals should only be required to make reasonable tradeoffs in order to pay for their health coverage. That is, health insurance is affordable if in order to pay for it one does not to have to sacrifice other benefit(s) that are comparable in importance to the benefits of health coverage. Adapted from the source document. JF - Kennedy Institute of Ethics Journal AU - Saenz, Carla AD - Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 401 EP - 414 PB - Johns Hopkins University Press, Baltimore MD VL - 19 IS - 4 SN - 1054-6863, 1054-6863 KW - Law and ethics - Ethics KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - United States KW - Bioethics KW - Health insurance KW - Health policy KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58847852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kennedy+Institute+of+Ethics+Journal&rft.atitle=Bioethics+Inside+the+Beltway%3A+What+is+Affordable+Health+Insurance%3F+The+Reasonable+Tradeoff+Account+of+Affordability&rft.au=Saenz%2C+Carla&rft.aulast=Saenz&rft.aufirst=Carla&rft.date=2009-12-01&rft.volume=19&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Kennedy+Institute+of+Ethics+Journal&rft.issn=10546863&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-28 N1 - CODEN - KIEJEF N1 - SubjectsTermNotLitGenreText - Bioethics; Health insurance; Health policy; United States; Medical service ER - TY - JOUR T1 - Comparing a Rule-Based Versus Statistical System for Automatic Categorization of MEDLINE Documents According to Biomedical Specialty AN - 57736282; 201001569 AB - Automatic document categorization is an important research problem in information Science and Natural Language Processing. Many applications, Including Word Sense Disambiguation and information Retrieval in large collections, can benefit from such categorization. This paper focuses on automatic categorization of documents from the biomedical literature Into broad discipline-based categories. Two different systems are described and contrasted: CISMeF, which uses rules based on human indexing of the documents by the Medical Subject Headings (MeSH) controlled vocabulary in order to assign metaterms (MTs), and Journal Descriptor Indexing (JDI), based on human categorization of about 4,000 Journals and statistical associations between Journal descriptors (JDs) and textwords in the documents. We evaluate and compare the performance of these systems against a gold standard of humanly assigned categories for 100 MEDLINE documents, using six measures selected from trec_eval. The results show that for five of the measures performance is comparable, and for one measure JDI is superior. We conclude that these results favor JDI, given the significantly greater intellectual overhead involved in human indexing and maintaining a rule base for mapping MeSH terms to MTs. We also note a JDI method that associates JDs with MeSH indexing rather than textwords, and it may be worthwhile to investigate whether this JDI method (statistical) and CISMeF (rule-based) might be combined and then evaluated showing they are complementary to one another. [Copyright Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Humphrey, Susanne M AU - Neveol, Aurelie AU - Browne, Allen AU - Gobeil, Julien AU - Ruch, Patrick AU - Darmoni, Stefan J AD - U.S. National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894 Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 2530 EP - 2539 PB - Wiley Subscription Services, Hoboken NJ VL - 60 IS - 12 SN - 1532-2882, 1532-2882 KW - Medicine KW - Automatic indexing KW - Text categorization KW - Automatic classification KW - article KW - 13.13: AUTOMATIC TEXT ANALYSIS, AUTOMATIC INDEXING, MACHINE TRANSLATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57736282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Comparing+a+Rule-Based+Versus+Statistical+System+for+Automatic+Categorization+of+MEDLINE+Documents+According+to+Biomedical+Specialty&rft.au=Humphrey%2C+Susanne+M%3BNeveol%2C+Aurelie%3BBrowne%2C+Allen%3BGobeil%2C+Julien%3BRuch%2C+Patrick%3BDarmoni%2C+Stefan+J&rft.aulast=Humphrey&rft.aufirst=Susanne&rft.date=2009-12-01&rft.volume=60&rft.issue=12&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Automatic classification; Text categorization; Automatic indexing; Medicine ER - TY - JOUR T1 - Physicians' decision-making style and psychosocial outcomes among cancer survivors AN - 57356628; 201006015 AB - Objective We evaluated pathways linking physicians' decision-making style with cancer survivors' health-related quality of life (HRQOL). Methods We analyzed survey data from 623 survivors diagnosed with leukemia, colorectal, or bladder cancer in Northern California, 2-5 years prior to the study. Of these, 395 reported making a medical decision in the past 12 months and were asked about their physician's decision-making style. We evaluated the association of physician style with proximal communication outcomes (trust and participation self-efficacy), intermediate cognitive outcomes (perceived control and uncertainty), and distal health outcomes (physical and mental HRQOL). Results Overall, 54% of survivors reported a sub-optimal decision-making style for their physician. With the exception of physical health, physician style was associated with all proximal, intermediate, and distal outcomes (p <= 0.01). We identified two significant pathways by which a participatory physician style may be associated with survivors' mental health: (1) by increasing survivors' participation self-efficacy and thereby enhancing their perceptions of personal control (p < 0.01); (2) by enhancing survivors' level of trust and thereby reducing their perceptions of uncertainty (p < 0.05). Conclusion A participatory physician style may improve survivors' mental health by a complex two-step mechanism of improving survivors' proximal communication and intermediate cognitive outcomes. Practice implications Physicians who adopt a participatory decision-making style are likely to facilitate patient empowerment and enhance patients' HRQOL. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Arora, Neeraj K AU - Weaver, Kathryn E AU - Clayman, Marla L AU - Oakley-Girvan, Ingrid AU - Potosky, Arnold L AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA aroran@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 404 EP - 412 PB - Elsevier Ltd, The Netherlands VL - 77 IS - 3 SN - 0738-3991, 0738-3991 KW - Patient-physician communication Participatory decision-making style Cancer survivorship Health-related quality of life Patient outcomes Mediation analysis KW - Selfefficacy KW - Decision making KW - Doctors KW - Health status KW - Survivors KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57356628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Physicians%27+decision-making+style+and+psychosocial+outcomes+among+cancer+survivors&rft.au=Arora%2C+Neeraj+K%3BWeaver%2C+Kathryn+E%3BClayman%2C+Marla+L%3BOakley-Girvan%2C+Ingrid%3BPotosky%2C+Arnold+L&rft.aulast=Arora&rft.aufirst=Neeraj&rft.date=2009-12-01&rft.volume=77&rft.issue=3&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2009.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Survivors; Doctors; Health status; Decision making; Quality of life; Selfefficacy DO - http://dx.doi.org/10.1016/j.pec.2009.10.004 ER - TY - JOUR T1 - PENS Column: Nonclassic Congenital Adrenal Hyperplasia: An Overview AN - 57353654; 201008563 AB - Abstract not available. JF - Journal of Pediatric Nursing AU - Van Ryzin, Carol AD - NIH Clinical Center, Bethesda, MD cvanryzin@cc.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 535 EP - 537 PB - Elsevier Ltd, The Netherlands VL - 24 IS - 6 SN - 0882-5963, 0882-5963 KW - Paediatrics KW - Nursing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57353654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Nursing&rft.atitle=PENS+Column%3A+Nonclassic+Congenital+Adrenal+Hyperplasia%3A+An+Overview&rft.au=Van+Ryzin%2C+Carol&rft.aulast=Van+Ryzin&rft.aufirst=Carol&rft.date=2009-12-01&rft.volume=24&rft.issue=6&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Nursing&rft.issn=08825963&rft_id=info:doi/10.1016%2Fj.pedn.2009.09.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Paediatrics DO - http://dx.doi.org/10.1016/j.pedn.2009.09.004 ER - TY - JOUR T1 - Device-guided slow-breathing effects on end-tidal CO2 and heart-rate variability AN - 57352417; 201005988 AB - Previous studies have reported that regular practice of a device-guided slow-breathing (DGB) exercise decreases resting blood pressure (BP) in hypertensive patients. The performance of DGB is associated with acute decreases in sympathetic vascular tone, and it has been suggested that the decreases in resting BP produced by regular practice of DGB over periods of weeks are due to chronic decreases in sympathetic nervous system activity. However, the kidneys respond to sympathetically mediated changes in BP by readjusting blood volume levels within a few days. Thus, the mechanism by which DGB could produce long-term BP changes remains to be clarified. Previous research with laboratory animals and human subjects has shown that slow, shallow breathing that increases pCO2 potentiates BP sensitivity to high sodium intake. These findings raise the possibility that deeper breathing during DGB that decreases BP might involve opposite changes in pCO2. The present study tested the hypothesis that performance of DGB acutely decreases a marker of pCO2, end-tidal CO2 (PetCO2). Breathing rate, tidal volume, and PetCO2 were monitored before, during, and after a 15-min session of DGB by patients with elevated BP. BP, heart rate, and heart-rate variability (HRV) were also measured under these conditions. A control group was also studied before, during, and after a 15-min session of spontaneous breathing (SB). The DGB group, but not the SB group, showed progressive and substantial increases in tidal volume and low-frequency HRV and decreases in PetCO2 and systolic BP. The PetCO2 effects persisted into the posttask, rest period. The findings are consistent with the hypothesis that habitual changes in breathing patterns of the kind observed during DGB could potentiate an antihypertensive adaptation via effects on pCO2 and its role in cardiovascular homeostasis. Adapted from the source document. JF - Psychology, Health & Medicine AU - Anderson, D E AU - McNeely, J D AU - Windham, B G AD - Clinical Research Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 667 EP - 679 PB - Routledge/Taylor & Francis, Abingdon UK VL - 14 IS - 6 SN - 1354-8506, 1354-8506 KW - Sodium KW - Variability KW - Breathing KW - Resting KW - Heart rate KW - Kidneys KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57352417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology%2C+Health+%26+Medicine&rft.atitle=Device-guided+slow-breathing+effects+on+end-tidal+CO2+and+heart-rate+variability&rft.au=Anderson%2C+D+E%3BMcNeely%2C+J+D%3BWindham%2C+B+G&rft.aulast=Anderson&rft.aufirst=D&rft.date=2009-12-01&rft.volume=14&rft.issue=6&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Psychology%2C+Health+%26+Medicine&rft.issn=13548506&rft_id=info:doi/10.1080%2F13548500903322791 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - PHMEFL N1 - SubjectsTermNotLitGenreText - Breathing; Resting; Variability; Sodium; Heart rate; Kidneys DO - http://dx.doi.org/10.1080/13548500903322791 ER - TY - JOUR T1 - Predictors of Perceived Ambiguity About Cancer Prevention Recommendations: Sociodemographic Factors and Mass Media Exposures AN - 57334084; 201004492 AB - Cancer prevention recommendations reaching the public today are often ambiguous--that is, of uncertain reliability, credibility, or adequacy--yet little is known about the factors that influence public perceptions of this ambiguity. We used data from the 2005 Health Information National Trends Survey, conducted by the U.S. National Cancer Institute, to explore how sociodemographic characteristics and self-reported mass media exposures relate to perceptions of ambiguity regarding recommendations for the prevention of colon, skin, and lung cancer. Various sociodemographic characteristics (age, education, race) and mass media exposures (television, radio, Internet, health news) were found to be associated with perceived ambiguity about cancer prevention recommendations, and many of these associations varied by cancer type. These findings have important implications for future health communication research and practice. Adapted from the source document. JF - Health Communication AU - Han, Paul K J AU - Moser, Richard P AU - Klein, William M P AU - Beckjord, Ellen Burke AU - Dunlavy, Andrea C AU - Hesse, Bradford W AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 764 EP - 772 PB - Taylor & Francis Group, Philadelphia PA VL - 24 IS - 8 SN - 1041-0236, 1041-0236 KW - Prevention KW - Sociodemographic aspects KW - Health information KW - Mass media KW - Ambiguity KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57334084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Predictors+of+Perceived+Ambiguity+About+Cancer+Prevention+Recommendations%3A+Sociodemographic+Factors+and+Mass+Media+Exposures&rft.au=Han%2C+Paul+K+J%3BMoser%2C+Richard+P%3BKlein%2C+William+M+P%3BBeckjord%2C+Ellen+Burke%3BDunlavy%2C+Andrea+C%3BHesse%2C+Bradford+W&rft.aulast=Han&rft.aufirst=Paul+K&rft.date=2009-12-01&rft.volume=24&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410230903242242 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Cancer; Ambiguity; Prevention; Sociodemographic aspects; Mass media; Health information DO - http://dx.doi.org/10.1080/10410230903242242 ER - TY - JOUR T1 - Immersive Virtual Environment Technology: A Promising Tool for Future Social and Behavioral Genomics Research and Practice AN - 57330823; 201005255 AB - Social and behavioral research needs to get started now if scientists are to direct genomic discoveries to address pressing public health problems. Advancing social and behavioral science will require innovative and rigorous communication methodologies that move researchers beyond reliance on traditional tools and their inherent limitations. One such emerging research tool is immersive virtual environment technology (virtual reality), a methodology that gives researchers the ability to maintain high experimental control and mundane realism of scenarios; portray and manipulate complex, abstract objects and concepts; and implement innovative implicit behavioral measurement. This report suggests the role that immersive virtual environment technology can play in furthering future research in genomics-related education, decision making, test intentions, behavior change, and health-care provider behaviors. Practical implementation and challenges are also discussed. Adapted from the source document. JF - Health Communication AU - Persky, Susan AU - McBride, Colleen M AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 677 EP - 682 PB - Taylor & Francis Group, Philadelphia PA VL - 24 IS - 8 SN - 1041-0236, 1041-0236 KW - Virtual reality KW - Medical research KW - Behavioural changes KW - Public health KW - Methodology KW - Technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57330823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Immersive+Virtual+Environment+Technology%3A+A+Promising+Tool+for+Future+Social+and+Behavioral+Genomics+Research+and+Practice&rft.au=Persky%2C+Susan%3BMcBride%2C+Colleen+M&rft.aulast=Persky&rft.aufirst=Susan&rft.date=2009-12-01&rft.volume=24&rft.issue=8&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410230903263982 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Technology; Medical research; Methodology; Public health; Virtual reality; Behavioural changes DO - http://dx.doi.org/10.1080/10410230903263982 ER - TY - JOUR T1 - Science, Technology, and Innovation: Nursing Responsibilities in Clinical Research AN - 57308361; 200928371 AB - Clinical research is a systematic investigation of human biology, health, or illness involving human beings. It builds on laboratory and animal studies and often involves clinical trials, which are specifically designed to test the safety and efficacy of interventions in humans. Nurses are critical to the conduct of ethical clinical research and face clinical, ethical, and regulatory challenges in research in many diverse roles. Understanding and addressing the ethical challenges that complicate clinical research is integral to upholding the moral commitment that nurses make to patients, including protecting their rights and ensuring their safety as patients and as research participants. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Grady, Christine AU - Edgerly, Maureen AD - Department of Bioethics, National Institutes of Health Clinical Center, Building 10/1C118, Bethesda, MD 20892, USA cgrady@nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 471 EP - 481 PB - Elsevier Ltd, The Netherlands VL - 44 IS - 4 SN - 0029-6465, 0029-6465 KW - Clinical research Ethics Science Nursing responsibilities Human subjects KW - Clinical nursing KW - Clinical research KW - Safety KW - Nurses KW - Clinical trials KW - Science and technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57308361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=Science%2C+Technology%2C+and+Innovation%3A+Nursing+Responsibilities+in+Clinical+Research&rft.au=Grady%2C+Christine%3BEdgerly%2C+Maureen&rft.aulast=Grady&rft.aufirst=Christine&rft.date=2009-12-01&rft.volume=44&rft.issue=4&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2009.07.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinical research; Nurses; Clinical nursing; Safety; Science and technology; Clinical trials DO - http://dx.doi.org/10.1016/j.cnur.2009.07.011 ER - TY - JOUR T1 - Disclosing the disclosure: factors associated with communicating the results of genetic susceptibility testing for Alzheimer's disease AN - 37241777; 3926631 AB - This study explored the extent to which recipients of genetic susceptibility testing for Alzheimer's disease (AD) communicated their results to others. It also examined demographic characteristics, along with beliefs about AD, associated with such communication. Participants (N = 271) in a randomized clinical trial involving genetic testing for Apolipoprotein E (APOE) gene variants among first-degree relatives of AD patients reported their communication behaviors 6 weeks after the results disclosure. Information on beliefs about AD and genetic testing was collected at baseline. Eighty-two percent of participants receiving APOE genotype information shared their results with someone. Specifically, 64% shared with family members, 51% with spouse or significant others, 35% with friends, and 12% with health care professionals. Greater AD treatment optimism was associated with communicating results to family (OR = 1.43), spouse (OR = 1.62), friends (OR = 1.81), and health care professionals (OR = 2.20). Lower perceived risk (OR = 0.98) and higher perceived importance of genetics in the development of AD (OR = 1.93) were associated with results communication in general. Lower perceived drawbacks of AD genetic testing was associated with results communication to friends (OR = 0.65). Beliefs about AD risks and causes, genetic testing, and development of treatments partly may determine the interpersonal communication patterns of genetic susceptibility test results. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Ashida, Sato AU - Koehly, Laura AU - Roberts, J Scott AU - Chen, Clara AU - Hiraki, Susan AU - Green, Robert AD - National Human Genome Research Institute, USA ; University of Michigan, Ann Arbor ; Boston University Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 768 EP - 784 VL - 14 IS - 8 SN - 1081-0730, 1081-0730 KW - Sociology KW - Human genetics KW - Alzheimer's disease KW - Communication KW - Medical treatment KW - Interpersonal relations KW - Beliefs KW - Information dissemination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37241777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Disclosing+the+disclosure%3A+factors+associated+with+communicating+the+results+of+genetic+susceptibility+testing+for+Alzheimer%27s+disease&rft.au=Ashida%2C+Sato%3BKoehly%2C+Laura%3BRoberts%2C+J+Scott%3BChen%2C+Clara%3BHiraki%2C+Susan%3BGreen%2C+Robert&rft.aulast=Ashida&rft.aufirst=Sato&rft.date=2009-12-01&rft.volume=14&rft.issue=8&rft.spage=768&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730903295518 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 942 3617 6220; 6081 5460 1615 8573 11325; 2572; 1547; 6823; 6520; 7890 5792 10484 DO - http://dx.doi.org/10.1080/10810730903295518 ER - TY - JOUR T1 - Cancer prevention information seeking: a signal detection analysis of data from the cancer information service AN - 37240109; 3926632 AB - Communication and health information seeking play a significant role in the promotion of cancer prevention behaviors, including screening. Data from a sample of information seekers who contacted the National Cancer Institute's (NCI's) Cancer Information Service (CIS; N = 20,412) were split randomly into an exploratory and validation sample to conduct signal detection analysis predicting cancer prevention information seeking. Important predictors of seeking prevention information in the exploratory sample were type of information seeker, communication channel, age, and gender; these findings generally were confirmed in the validation sample. Our findings also reveal important information about the demographic characteristics and communication channel preferences of cancer prevention information seekers. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Sullivan, Helen AU - Rutten, Lila J. Finney AD - National Institutes of Health, USA Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 785 EP - 796 VL - 14 IS - 8 SN - 1081-0730, 1081-0730 KW - Sociology KW - Screening KW - Age KW - Prevention KW - Information acquisition KW - Gender KW - Communication KW - Data analysis KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37240109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Cancer+prevention+information+seeking%3A+a+signal+detection+analysis+of+data+from+the+cancer+information+service&rft.au=Sullivan%2C+Helen%3BRutten%2C+Lila+J.+Finney&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2009-12-01&rft.volume=14&rft.issue=8&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730903295534 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 10072; 6516; 2572; 646; 5421 6091; 3279 971 3286 DO - http://dx.doi.org/10.1080/10810730903295534 ER - TY - JOUR T1 - BchY-Based Degenerate Primers Target All Types of Anoxygenic Photosynthetic Bacteria in a Single PCR , , AN - 21508755; 12510481 AB - To detect anoxygenic bacteria containing either type 1 or type 2 photosynthetic reaction centers in a single PCR, we designed a degenerate primer set based on the bchY gene. The new primers were validated in silico using the GenBank nucleotide database as well as by PCR on pure strains and environmental DNA. JF - Applied and Environmental Microbiology AU - Yutin, Natalya AU - Suzuki, Marcelino T AU - Rosenberg, Mira AU - Rotem, Denisse AU - Madigan, Michael T AU - Sueling, Joerg AU - Imhoff, Johannes F AU - Beja, Oded AD - Faculty of Biology, Technion, Israel Institute of Technology, Haifa 32000, Israel, yutin@ncbi.nlm.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 7556 EP - 7559 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 23 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Databases KW - Polymerase chain reaction KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=BchY-Based+Degenerate+Primers+Target+All+Types+of+Anoxygenic+Photosynthetic+Bacteria+in+a+Single+PCR+%2C+%2C&rft.au=Yutin%2C+Natalya%3BSuzuki%2C+Marcelino+T%3BRosenberg%2C+Mira%3BRotem%2C+Denisse%3BMadigan%2C+Michael+T%3BSueling%2C+Joerg%3BImhoff%2C+Johannes+F%3BBeja%2C+Oded&rft.aulast=Yutin&rft.aufirst=Natalya&rft.date=2009-12-01&rft.volume=75&rft.issue=23&rft.spage=7556&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01014-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Polymerase chain reaction DO - http://dx.doi.org/10.1128/AEM.01014-09 ER - TY - JOUR T1 - Transplantation of Hippocampal Cell Lines Restore Spatial Learning in Rats With Ventral Subicular Lesions AN - 21457944; 11788329 AB - We have demonstrated in our previous studies that ventral subicular lesion induces neurodegeneration of the hippocampus and produces cognitive impairment in rats. In the present study, the efficacy of transplanted green fluorescent protein (GFP)-labeled hippocampal cell line (H3-GFP) cells in establishing functional recovery in ventral subicular lesioned rats has been evaluated. The survival of H3-GFP transplants and their ability to express trophic factors in vivo were also investigated. Adult male Wistar rats were subjected to selective lesioning of ventral subiculum and were transplanted with H3-GFP cells into the cornu ammonis 1 (CA1) hippocampus. The transplants settled mainly in the dentate gyrus and expressed neurotrophic factors, brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF). The ventral subicular lesioned (VSL) rats with H3-GFP transplants showed enhanced expression of BDNF in the hippocampus and performed well in eight-arm radial maze and Morris water maze tasks. The VSL rats without hippocampal transplants continued to show cognitive impairment in task learning. The present study demonstrated the H3-GFP transplants mediated recovery of cognitive functions in VSL rats. Our study supports the notion of graft meditated host regeneration and functional recovery through trophic support, although these mechanisms require further investigation. JF - Behavioral Neuroscience AU - Rekha, J AU - Chakravarthy, Sridhara AU - Veena, L R AU - Kalai, Vani P AU - Choudhury, Rupam AU - Halahalli, Harsha N AU - Alladi, Phalguni Anand AU - Dhanushkodi, Anandh AU - Nirmala, M AU - Swamilingiah, Geetha M AU - Agrahari, Maulishree AU - Raju, T R AU - Panicker, M M AU - Kutty, Bindu M AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS Deemed University), Bangalore, India, bindu.nimhans@gmail.com Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1197 EP - 1217 PB - American Psychological Association, 750 First St., N.E. Washington DC 20002-4242 USA VL - 123 IS - 6 SN - 0735-7044, 0735-7044 KW - Biotechnology and Bioengineering Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - brain lesion KW - neurodegeneration KW - learning impairment KW - hippocampal transplants KW - trophic factors KW - Brain-derived neurotrophic factor KW - Learning KW - Transplantation KW - Hippocampus KW - Neurotrophic factors KW - Green fluorescent protein KW - Neurodegeneration KW - Recovery of function KW - Dentate gyrus KW - Transplants KW - spatial memory KW - Nervous system KW - Cognitive ability KW - Regeneration KW - Trophic factors KW - Fibroblast growth factor 2 KW - Spatial discrimination learning KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21457944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Neuroscience&rft.atitle=Transplantation+of+Hippocampal+Cell+Lines+Restore+Spatial+Learning+in+Rats+With+Ventral+Subicular+Lesions&rft.au=Rekha%2C+J%3BChakravarthy%2C+Sridhara%3BVeena%2C+L+R%3BKalai%2C+Vani+P%3BChoudhury%2C+Rupam%3BHalahalli%2C+Harsha+N%3BAlladi%2C+Phalguni+Anand%3BDhanushkodi%2C+Anandh%3BNirmala%2C+M%3BSwamilingiah%2C+Geetha+M%3BAgrahari%2C+Maulishree%3BRaju%2C+T+R%3BPanicker%2C+M+M%3BKutty%2C+Bindu+M&rft.aulast=Rekha&rft.aufirst=J&rft.date=2009-12-01&rft.volume=123&rft.issue=6&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Behavioral+Neuroscience&rft.issn=07357044&rft_id=info:doi/10.1037%2Fa0017655 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Learning; Transplantation; Hippocampus; Neurotrophic factors; Green fluorescent protein; Recovery of function; Neurodegeneration; Dentate gyrus; Transplants; spatial memory; Nervous system; Cognitive ability; Regeneration; Trophic factors; Spatial discrimination learning; Fibroblast growth factor 2 DO - http://dx.doi.org/10.1037/a0017655 ER - TY - JOUR T1 - Discrepant Prevalence and Incidence of Leishmania Infection between Two Neighboring Villages in Central Mali Based on Leishmanin Skin Test Surveys AN - 21448746; 11867431 AB - Apart from a single report, the last publication of cutaneous leishmaniasis (CL) in Mali dates back more than 20 years. The absence of information on the current status of CL in Mali led us to conduct a cohort study in Kemena and Sougoula, two villages in Central Mali from which cases of CL have been recently diagnosed by Mali's reference dermatology center in Bamako. In May 2006, we determined the baseline prevalence of Leishmania infection in the two villages using the leishmanin skin test (LST). LST-negative individuals were then re-tested over two consecutive years to estimate the annual incidence of Leishmania infection. The prevalence of Leishmania infection was significantly higher in Kemena than in Sougoula (45.4% vs. 19.9%; OR: 3.36, CI: 2.66a4.18). The annual incidence of Leishmania infection was also significantly higher in Kemena (18.5% and 17% for 2007 and 2008, respectively) than in Sougoula (5.7% for both years). These data demonstrate that the risk of Leishmania infection was stable in both villages and confirm the initial observation of a significantly higher risk of infection in Kemena (OR: 3.78; CI: 2.45a6.18 in 2007; and OR: 3.36; CI: 1.95a5.8 in 2008; P&0.005). The absence of spatial clustering of LST-positive individuals in both villages indicated that transmission may be occurring anywhere within the villages. Although Kemena and Sougoula are only 5 km apart and share epidemiologic characteristics such as stable transmission and random distribution of LST-positive individuals, they differ markedly in the prevalence and annual incidence of Leishmania infection. Here we establish ongoing transmission of Leishmania in Kemena and Sougoula, Central Mali, and are currently investigating the underlying factors that may be responsible for the discrepant infection rates we observed between them. Trial Registration ClinicalTrials.gov NCT00344084 Author Summary Leishmaniasis is a vector-borne disease transmitted to humans by the bite of an infected sand fly. Leishmaniasis is present in more than 88 countries and affects more than 12 million people. Depending on the species of Leishmania, the host can develop cutaneous leishmaniasis (CL), which is characterized by skin ulcers in uncovered parts of the body or a more severe form, visceral leishmaniasis, which affects the liver and spleen and is fatal if not treated. This study aims to establish the past and present infection with Leishmania parasites in two villages where recent cases have been diagnosed by the dermatology center (CNAM) in Bamako. This was achieved using a Leishmania-specific skin test that was administered annually to permanent residents of Kemena and Sougoula villages from 2006 to 2008. The results show that transmission of Leishmania is active and stable in these two villages. Moreover, despite sharing similar cultural and environmental features, the individuals from Kemena presented three times the risk of Leishmania infection compared with those from Sougoula. Our findings raise awareness of the continued presence of CL in Mali. JF - PLoS Neglected Tropical Diseases AU - Oliveira, Fabiano AU - Doumbia, Seydou AU - Anderson, Jennifer M AU - Faye, Ousmane AU - Diarra, Souleymane S AU - TraorACO, Pierre AU - Cisse, Moumine AU - Camara, Guimba AU - Tall, Koureissi AU - Coulibaly, Cheick A AU - Samake, Sibiry AU - Sissoko, Ibrahim AU - TraorACO, Bourama AU - Diallo, Daouda AU - Keita, Somita AU - Fairhurst, Rick M AU - Valenzuela, Jesus G AU - Kamhawi, Shaden AU - Louzir, Hechmi AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 3 IS - 12 SN - 1935-2727, 1935-2727 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Data processing KW - Bites KW - Visceral leishmaniasis KW - Vector-borne diseases KW - Dermatology KW - Spleen KW - leishmanin KW - Infection KW - Disease transmission KW - Skin tests KW - Leishmania KW - Ulcers KW - Risk factors KW - Liver KW - Cutaneous leishmaniasis KW - K 03400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21448746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Discrepant+Prevalence+and+Incidence+of+Leishmania+Infection+between+Two+Neighboring+Villages+in+Central+Mali+Based+on+Leishmanin+Skin+Test+Surveys&rft.au=Oliveira%2C+Fabiano%3BDoumbia%2C+Seydou%3BAnderson%2C+Jennifer+M%3BFaye%2C+Ousmane%3BDiarra%2C+Souleymane+S%3BTraorACO%2C+Pierre%3BCisse%2C+Moumine%3BCamara%2C+Guimba%3BTall%2C+Koureissi%3BCoulibaly%2C+Cheick+A%3BSamake%2C+Sibiry%3BSissoko%2C+Ibrahim%3BTraorACO%2C+Bourama%3BDiallo%2C+Daouda%3BKeita%2C+Somita%3BFairhurst%2C+Rick+M%3BValenzuela%2C+Jesus+G%3BKamhawi%2C+Shaden%3BLouzir%2C+Hechmi&rft.aulast=Oliveira&rft.aufirst=Fabiano&rft.date=2009-12-01&rft.volume=3&rft.issue=12&rft.spage=e565&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0000565 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Parasites; Data processing; Bites; Visceral leishmaniasis; Vector-borne diseases; Dermatology; Spleen; leishmanin; Infection; Skin tests; Disease transmission; Ulcers; Risk factors; Liver; Cutaneous leishmaniasis; Leishmania DO - http://dx.doi.org/10.1371/journal.pntd.0000565 ER - TY - JOUR T1 - Neurodevelopmental disorders: Cluster 2 of the proposed meta-structure for DSM-V and ICD-11 AN - 21341057; 11825850 AB - DSM-IV and ICD-10 are atheoretical and largely descriptive. Although this achieves good reliability, the validity of diagnoses can be increased by an understanding of risk factors and other clinical features. In an effort to group mental disorders on this basis, five clusters have been proposed. We now consider the second cluster, namely neurodevelopmental disorders. We reviewed the literature in relation to 11 validating criteria proposed by a DSM-V Task Force Study Group. This cluster reflects disorders of neurodevelopment rather than a 'childhood' disorders cluster. It comprises disorders subcategorized in DSM-IV and ICD-10 as Mental Retardation; Learning, Motor, and Communication Disorders; and Pervasive Developmental Disorders. Although these disorders seem to be heterogeneous, they share similarities on some risk and clinical factors. There is evidence of a neurodevelopmental genetic phenotype, the disorders have an early emerging and continuing course, and all have salient cognitive symptoms. Within-cluster co-morbidity also supports grouping these disorders together. Other childhood disorders currently listed in DSM-IV share similarities with the Externalizing and Emotional clusters. These include Conduct Disorder, Attention Deficit Hyperactivity Disorder and Separation Anxiety Disorder. The Tic, Eating/Feeding and Elimination disorders, and Selective Mutisms were allocated to the 'Not Yet Assigned' group. Neurodevelopmental disorders meet some of the salient criteria proposed by the American Psychiatric Association (APA) to suggest a classification cluster. JF - Psychological Medicine AU - Andrews, G AU - Pine, D S AU - Hobbs, MJ AU - Anderson, T M AU - Sunderland, M AD - National Institute of Mental Health, Bethesda, MD, USA, gavina@unsw.edu.au Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 2013 EP - 2023 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU UK VL - 39 IS - 12 SN - 0033-2917, 0033-2917 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Neurodevelopmental disorders KW - Emotions KW - Anxiety KW - Psychology KW - Attention deficit hyperactivity disorder KW - Communication KW - Morbidity KW - Mental disorders KW - Classification KW - Risk factors KW - Mental retardation KW - Motor skill learning KW - Feeding KW - Children KW - Communications KW - Cognitive ability KW - Reviews KW - classification KW - mental disorders KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21341057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Neurodevelopmental+disorders%3A+Cluster+2+of+the+proposed+meta-structure+for+DSM-V+and+ICD-11&rft.au=Andrews%2C+G%3BPine%2C+D+S%3BHobbs%2C+MJ%3BAnderson%2C+T+M%3BSunderland%2C+M&rft.aulast=Andrews&rft.aufirst=G&rft.date=2009-12-01&rft.volume=39&rft.issue=12&rft.spage=2013&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291709990274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; Emotions; Feeding; Anxiety; Attention deficit hyperactivity disorder; Communication; Children; Mental disorders; Classification; Cognitive ability; Reviews; Risk factors; Mental retardation; Motor skill learning; Communications; Psychology; classification; mental disorders; Morbidity DO - http://dx.doi.org/10.1017/S0033291709990274 ER - TY - JOUR T1 - The spectrum of latent tuberculosis: rethinking the biology and intervention strategies AN - 21338071; 11700109 AB - Immunological tests provide evidence of latent tuberculosis in one third of the global population, which corresponds to more than two billion individuals. Latent tuberculosis is defined by the absence of clinical symptoms but carries a risk of subsequent progression to clinical disease, particularly in the context of co-infection with HIV. In this Review we discuss the biology of latent tuberculosis as part of a broad range of responses that occur following infection with Mycobacterium tuberculosis, which result in the formation of physiologically distinct granulomatous lesions that provide microenvironments with differential ability to support or suppress the persistence of viable bacteria. We then show how this model can be used to develop a rational programme to discover effective drugs for the eradication of M. tuberculosis infection. JF - Nature Reviews: Microbiology AU - Barry, Clifton E AU - Boshoff, Helena I AU - Dartois, Veronique AU - Dick, Thomas AU - Ehrt, Sabine AU - Flynn, JoAnne AU - Schnappinger, Dirk AU - Wilkinson, Robert J AU - Young, Douglas AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 845 EP - 855 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 7 IS - 12 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts B: Bacteriology KW - Human immunodeficiency virus KW - Microenvironments KW - Tuberculosis KW - Infection KW - Drugs KW - Mycobacterium tuberculosis KW - Models KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21338071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=The+spectrum+of+latent+tuberculosis%3A+rethinking+the+biology+and+intervention+strategies&rft.au=Barry%2C+Clifton+E%3BBoshoff%2C+Helena+I%3BDartois%2C+Veronique%3BDick%2C+Thomas%3BEhrt%2C+Sabine%3BFlynn%2C+JoAnne%3BSchnappinger%2C+Dirk%3BWilkinson%2C+Robert+J%3BYoung%2C+Douglas&rft.aulast=Barry&rft.aufirst=Clifton&rft.date=2009-12-01&rft.volume=7&rft.issue=12&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Microenvironments; Tuberculosis; Infection; Drugs; Models; Human immunodeficiency virus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1038/nrmicro2236 ER - TY - JOUR T1 - Structural and Genetic Analysis of X-Ray Scattering by Spores of Bacillus subtilis AN - 21324934; 11917133 AB - Dormant spores of Bacillus subtilis exhibit two prominent X-ray scattering peaks. These peaks persisted in spores lacking most /?-type small, acid-soluble protein or the CotE protein responsible for assembly of much spore coat protein, but they were absent from spores of strains lacking the late sporulation-specific transcription factor GerE. JF - Journal of Bacteriology AU - Qiu, Xiangyun AU - Setlow, Peter AD - Laboratory of Physical and Structural Biology, Program in Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-0924, setlow@nso2.uchc.edu Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 7620 EP - 7622 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 24 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - Spore coats KW - Transcription factors KW - Genetic analysis KW - X-ray scattering KW - CotE protein KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21324934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Structural+and+Genetic+Analysis+of+X-Ray+Scattering+by+Spores+of+Bacillus+subtilis&rft.au=Qiu%2C+Xiangyun%3BSetlow%2C+Peter&rft.aulast=Qiu&rft.aufirst=Xiangyun&rft.date=2009-12-01&rft.volume=191&rft.issue=24&rft.spage=7620&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01200-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 23 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Transcription factors; Spore coats; Genetic analysis; X-ray scattering; CotE protein; Bacillus subtilis DO - http://dx.doi.org/10.1128/JB.01200-09 ER - TY - JOUR T1 - Comparison of Bioluminescent Kinase Assays Using Substrate Depletion and Product Formation AN - 21324605; 11923185 AB - Assays for ATPases have been enabled for high-throughput screening (HTS) by employing firefly luciferase to detect the remaining ATP in the assay. However, for any enzyme assay, measurement of product formation is a more sensitive assay design. Recently, technologies that allow detection of the ADP product from ATPase reactions have been described using fluorescent methods of detection. We describe here the characterization of a bioluminescent assay that employs firefly luciferase in a coupled-enzyme assay format to enable detection of ADP levels from ATPase assays (ADP-Glo+, Promega Corp.). We determined the performance of the ADP-Glo assay in 1,536-well microtiter plates using the protein kinase Clk4 and a 1,352 member kinase focused combinatorial library. The ADP-Glo assay was compared to the Clk4 assay performed using a bioluminescence ATP-depletion format (Kinase-Glo, Promega Corp). We performed this analysis using quantitative HTS (qHTS) where we determined potency values for all library members and identified 6300 compounds with potencies ranging from as low as 50 nM to >10 kM, yielding a robust dataset for the comparison. Both assay formats showed high performance (Z'-factors 60.9) and showed a similar potency distribution for the actives. We conclude that the bioluminescence ADP detection assay system is a viable generic alternative to the widely used ATP-depletion assay for ATPases and discuss the advantages and disadvantages of both approaches. JF - Assay and Drug Development Technologies AU - Tanega, C AU - Shen, M AU - Mott, B T AU - Thomas, C J AU - MacArthur, R AU - Inglese, J AU - Auld, D S AD - NIH Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA, dauld@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 606 EP - 614 VL - 7 IS - 6 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Protein kinase C KW - Adenosinetriphosphatase KW - Bioluminescence KW - ATP KW - Enzymes KW - Drug development KW - high-throughput screening KW - Combinatorial libraries KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21324605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=Comparison+of+Bioluminescent+Kinase+Assays+Using+Substrate+Depletion+and+Product+Formation&rft.au=Tanega%2C+C%3BShen%2C+M%3BMott%2C+B+T%3BThomas%2C+C+J%3BMacArthur%2C+R%3BInglese%2C+J%3BAuld%2C+D+S&rft.aulast=Tanega&rft.aufirst=C&rft.date=2009-12-01&rft.volume=7&rft.issue=6&rft.spage=606&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2009.0230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Adenosinetriphosphatase; Bioluminescence; Enzymes; ATP; high-throughput screening; Drug development; Combinatorial libraries DO - http://dx.doi.org/10.1089/adt.2009.0230 ER - TY - JOUR T1 - Lay interpersonal sources for health information related to beliefs about the modifiability of cancer risk AN - 21324001; 11906517 AB - Objective: Causal beliefs about cancer may influence preventive behaviors and medical care. We examined the relationship between beliefs about causation for lung, colon, and skin cancer and the use of lay interpersonal sources of health information (community organizations, family, friends). Methods: Data from a nationally representative sample of 5,119 adult respondents to the 2005 Health Information National Trends Survey were analyzed. Results: About 40% of respondents reported that community organizations provided them with health information, while 15% discussed health information 'very frequently' with their family or friends. In multivariate models, individuals who never spoke with family or friends about health were more likely to believe that colon cancer risk is not modifiable; those provided with health information by community organizations were less likely to believe that skin cancer risk is not modifiable. Speaking with family or friends about health was also associated with endorsing the belief that skin cancer is caused by behavior or lifestyle. Conclusion: These findings showed that lay interpersonal health information sources are associated with beliefs about the modifiability of colon and skin cancer risk. Future research is needed to investigate whether and how such information sources might influence decisions about engaging in preventive behaviors. JF - Cancer Causes & Control AU - Ford, Beth M AU - Kaphingst, Kimberly A AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Building 31, Room B1B37E, 31 Center Drive, MSC 2073, Bethesda, MD, 20892, USA, kkaphing@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1975 EP - 1983 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Skin KW - Lung KW - community organizations KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21324001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Lay+interpersonal+sources+for+health+information+related+to+beliefs+about+the+modifiability+of+cancer+risk&rft.au=Ford%2C+Beth+M%3BKaphingst%2C+Kimberly+A&rft.aulast=Ford&rft.aufirst=Beth&rft.date=2009-12-01&rft.volume=20&rft.issue=10&rft.spage=1975&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9392-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Skin; Lung; community organizations; Cancer DO - http://dx.doi.org/10.1007/s10552-009-9392-1 ER - TY - JOUR T1 - Bladder cancer and reproductive factors among women in Spain AN - 21323980; 11906509 AB - Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer risk. Information on reproductive and other risk factors was gathered in personal interviews from 152 female cases and 166 matched controls from 18 hospitals in five regions of Spain during 1998-2001. Logistic regression was used to estimate the association between bladder cancer and reproductive factors, including ever-parous status, age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation. After adjustment for age, smoking, and high-risk occupation, ever-parous women were at decreased risk relative to nulliparous women (odds ratio=0.43, 95% confidence interval=0.21-0.87). There was no consistent pattern in risk with the age- or duration-related reproductive factors (e.g., age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation) that we evaluated. Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role. JF - Cancer Causes & Control AU - Huang, An-Tsun AU - Kogevinas, Manolis AU - Silverman, Debra T AU - Malats, Na'ria AU - Rothman, Nathaniel AU - Tardon, Adonina AU - Serra, Consol AU - Garcia-Closas, Reina AU - Carrato, Alfredo AU - Cantor, Kenneth P AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, huangan@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1907 EP - 1913 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 10 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - urinary bladder KW - Smoking KW - Age KW - Spain KW - menopause KW - Females KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21323980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Bladder+cancer+and+reproductive+factors+among+women+in+Spain&rft.au=Huang%2C+An-Tsun%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra+T%3BMalats%2C+Na%27ria%3BRothman%2C+Nathaniel%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BGarcia-Closas%2C+Reina%3BCarrato%2C+Alfredo%3BCantor%2C+Kenneth+P&rft.aulast=Huang&rft.aufirst=An-Tsun&rft.date=2009-12-01&rft.volume=20&rft.issue=10&rft.spage=1907&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9384-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; urinary bladder; Age; menopause; Females; Cancer; Spain DO - http://dx.doi.org/10.1007/s10552-009-9384-1 ER - TY - JOUR T1 - Joint associations of physical activity and sedentary behaviors with body mass index: results from a time use survey of US adults AN - 21315629; 11936525 AB - Objective:Obesity risk is negatively associated with physical activity and positively associated with time spent in sedentary behaviors. Yet, it is not known how different combinations of sedentary and active behavior are associated with body mass index (BMI). This study examined the interaction between time spent in physical activity and sedentary behavior on BMI in US adults.Design:Cross-sectional, data from the 2006 American Time Use Survey.Subjects:10984 non-underweight adults (aged 21 + years).Measurement:A phone interview assessed all activities performed in the past 24h, height, weight, health status, and other sociodemographic characteristics. Time spent in (1) moderate-to-vigorous leisure-time physical activity (MVPA), (2) active transportation (walking, biking), (3) sedentary leisure activities (TV/movie watching, computer use, playing games, reading), and (4) sedentary transportation (motorized vehicles) was determined from activity coding. BMI was calculated. Results:After adjusting for age, gender, education level, race/ethnicity, and health status, sample-weighted linear regressions found significant interactions for leisure MVPA TV/movies, leisure MVPA playing games, active transportation sedentary transportation, and active transportation reading (Ps<0.0001). For example, the group of adults watching <60min per day of TV/movies and engaging in .60min per day of leisure MVPA had lower average BMI compared to the group watching <60min per day of TV/movies and reporting <60min per day of leisure MVPA (P<0.0001). In contrast, for adults watching .189min per day of TV/movies, there was not a significant difference in BMI by time spent in leisure MVPA. Conclusion:Data from a US time use survey indicate that the strength of the association between certain types of sedentary behavior and BMI varies according to time spent in certain types of physical activity and vice versa. JF - International Journal of Obesity AU - Dunton, G F AU - Berrigan, D AU - Ballard-Barbash, R AU - Graubard, B AU - Atienza, A A AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1427 EP - 1436 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 33 IS - 12 SN - 0307-0565, 0307-0565 KW - Health & Safety Science Abstracts; Risk Abstracts; Physical Education Index KW - Age KW - Reading KW - Body mass KW - obesity KW - Adults KW - Transportation KW - body mass KW - Television KW - physical activity KW - Ethnic groups KW - Surveys KW - Exercise KW - USA KW - Education KW - Behavior KW - Leisure KW - Gender KW - Activities KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21315629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Joint+associations+of+physical+activity+and+sedentary+behaviors+with+body+mass+index%3A+results+from+a+time+use+survey+of+US+adults&rft.au=Dunton%2C+G+F%3BBerrigan%2C+D%3BBallard-Barbash%2C+R%3BGraubard%2C+B%3BAtienza%2C+A+A&rft.aulast=Dunton&rft.aufirst=G&rft.date=2009-12-01&rft.volume=33&rft.issue=12&rft.spage=1427&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2009.174 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Reading; Behavior; Leisure; Body mass; Television; Surveys; Adults; Exercise; Activities; Age; Education; Transportation; body mass; Gender; obesity; physical activity; Ethnic groups; USA DO - http://dx.doi.org/10.1038/ijo.2009.174 ER - TY - JOUR T1 - Jasmine tea consumption and upper gastrointestinal cancer in China AN - 21311730; 11906519 AB - Introduction: Epidemiological data on green/jasmine tea and esophageal as well as gastric cancer are limited and inconclusive. Methods: In order to study the effect of jasmine tea in upper gastrointestinal (UGI) cancers, we evaluated 600 esophageal squamous cell carcinoma (ESCC), 598 gastric cardia cancer (GCA), and 316 gastric non-cardia cancer (GNCA) cases and 1,514 age-, gender-, and neighborhood-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from logistic regression adjusted for matching factors and potential confounders. Results: Among controls, 35% of males and 8% of females reported consumption of jasmine tea; other tea consumption was rare. Consumption of jasmine tea (ever vs. never) was not associated with risk of ESCC (OR=1.15, 95% CI 0.92-1.44), GCA (OR=1.14, 95% CI 0.88-1.37), or GNCA (OR=0.85, 95% CI 0.64-1.15) in males and females combined. Among males, cumulative lifetime consumption showed a significant positive dose-response relation with ESCC risk, but not for GCA and GNCA. In exploratory analyses, occupation affected the relation between tea and ESCC such that consumption in males was associated with increased risk only in non-office workers. Conclusion: Overall, we found no evidence for a protective effect of tea in esophageal or gastric cancer. Further studies of the potential effects of thermal damage, tea quality, and water quality on UGI cancers are suggested. JF - Cancer Causes & Control AU - Gao, Ying AU - Hu, Nan AU - Han, XiaoYou AU - Giffen, Carol AU - Ding, Ti AU - Goldstein, Alisa M AU - Taylor, Philip R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, gaoying@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1997 EP - 2007 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 10 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Esophagus KW - water quality KW - Data processing KW - Jasminum KW - squamous cell carcinoma KW - tea KW - Water quality KW - Cancer KW - Workers KW - Tea KW - Dose-response effects KW - China, People's Rep. KW - Gastric cancer KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21311730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Jasmine+tea+consumption+and+upper+gastrointestinal+cancer+in+China&rft.au=Nepomnaschy%2C+P+A%3BBaird%2C+D+D%3BWeinberg%2C+C+R%3BHoppin%2C+J+A%3BLongnecker%2C+M+P%3BWilcox%2C+A+J&rft.aulast=Nepomnaschy&rft.aufirst=P&rft.date=2009-08-01&rft.volume=109&rft.issue=6&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2009.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Workers; Data processing; Tea; squamous cell carcinoma; Water quality; Gastric cancer; water quality; Dose-response effects; tea; Cancer; Jasminum; China, People's Rep. DO - http://dx.doi.org/10.1007/s10552-009-9394-z ER - TY - JOUR T1 - Blocking Interleukin-1 in Rheumatic Diseases AN - 21297659; 11838881 AB - The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret registered ), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of patients with rheumatoid arthritis. More recently IL-1 blocking therapies are used successfully to treat a new group of immune-mediated inflammatory conditions, autoinflammatory diseases. These conditions include rare hereditary fever syndromes and pediatric and adult conditions of Still's disease. Recently the FDA approved two additional longer acting IL-1 blocking agents, for the treatment of cryopyrin-associated periodic syndromes (CAPS), an IL-1 dependent autoinflammatory syndrome. The study of autoinflammatory diseases revealed mechanisms of IL-1 mediated organ damage and provided concepts to a better understanding of the pathogenesis of more common diseases such as gout and Type 2 diabetes which show initial promising results with IL-1 blocking therapy. JF - Annals of the New York Academy of Sciences AU - Goldbach-Mansky, Raphaela AD - aNational Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 111 EP - 123 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 1182 IS - 1 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Diabetes mellitus KW - Fever KW - Gout KW - Inflammation KW - Inflammatory diseases KW - Interleukin 1 KW - Interleukin 1 receptor antagonist KW - Juvenile rheumatoid arthritis KW - Pediatrics KW - Rheumatic diseases KW - Rheumatoid arthritis KW - Sepsis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21297659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Blocking+Interleukin-1+in+Rheumatic+Diseases&rft.au=Goldbach-Mansky%2C+Raphaela&rft.aulast=Goldbach-Mansky&rft.aufirst=Raphaela&rft.date=2009-12-01&rft.volume=1182&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.05159.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Fever; Rheumatoid arthritis; Sepsis; Inflammatory diseases; Pediatrics; Interleukin 1; Juvenile rheumatoid arthritis; Gout; Interleukin 1 receptor antagonist; Rheumatic diseases; Inflammation DO - http://dx.doi.org/10.1111/j.1749-6632.2009.05159.x ER - TY - JOUR T1 - Role for the Burkholderia pseudomallei Capsular Polysaccharide Encoded by the wcb Operon in Acute Disseminated Melioidosis, AN - 21252858; 11811851 AB - The capsular polysaccharide of Burkholderia pseudomallei is an essential virulence determinant that is required for protection from host serum cidal activity and opsonophagocytosis. In this study, the immune response directed against a B. pseudomallei capsule mutant (JW270) was investigated in an acute respiratory murine model. JW270 was significantly attenuated in this model (2 logs) to levels resembling those of avirulent Burkholderia thailandensis. At lethal doses, JW270 colonized the lung, liver, and spleen at levels similar to the wild-type strain levels and was found to trigger reduced pathology in the liver and spleen. Several cytokine responses were altered in these tissues, and importantly, the levels of gamma interferon were reduced in the livers and spleens of JW270-infected mice but not in the lungs. These results suggest that the capsular polysaccharide of B. pseudomallei is a critical virulence determinant in respiratory tract infections and that it is an important antigen for generating the Th1 immune response commonly observed in systemic melioidosis. Furthermore, the data suggest that host recognition of B. pseudomallei capsular polysaccharide in the lungs may not be as important to the disease outcome as the innate immune response in the peripheral organs. JF - Infection and Immunity AU - Warawa, Jonathan M AU - Long, Dan AU - Rosenke, Rebecca AU - Gardner, Don AU - Gherardini, Frank C AD - Laboratory of Zoonotic Pathogens, fgherardini@niaid.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 5252 EP - 5261 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 12 SN - 0019-9567, 0019-9567 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Helper cells KW - Respiration KW - Animal models KW - Melioidosis KW - opsonophagocytosis KW - Hosts KW - Infection KW - Polysaccharides KW - Defence mechanisms KW - Models KW - Virulence KW - Lymphocytes T KW - Capsular polysaccharides KW - Burkholderia pseudomallei KW - g-Interferon KW - Data processing KW - Spleen KW - Immunity KW - Burkholderia thailandensis KW - Respiratory tract diseases KW - Lung KW - Liver KW - Lungs KW - Immune response KW - Operons KW - Metabolism KW - Lethal dose KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - N 14845:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21252858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Role+for+the+Burkholderia+pseudomallei+Capsular+Polysaccharide+Encoded+by+the+wcb+Operon+in+Acute+Disseminated+Melioidosis%2C&rft.au=Warawa%2C+Jonathan+M%3BLong%2C+Dan%3BRosenke%2C+Rebecca%3BGardner%2C+Don%3BGherardini%2C+Frank+C&rft.aulast=Warawa&rft.aufirst=Jonathan&rft.date=2009-12-01&rft.volume=77&rft.issue=12&rft.spage=5252&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00824-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - Virulence; Respiration; Lungs; Spleen; Hosts; Immunity; Defence mechanisms; Polysaccharides; Metabolism; Data processing; g-Interferon; Helper cells; opsonophagocytosis; Melioidosis; Animal models; Infection; Models; Respiratory tract diseases; Lung; Liver; Lymphocytes T; Immune response; Operons; Capsular polysaccharides; Lethal dose; Burkholderia thailandensis; Burkholderia pseudomallei DO - http://dx.doi.org/10.1128/IAI.00824-09 ER - TY - JOUR T1 - A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer-experiences of the mother AN - 21248701; 11604696 AB - Background We undertook a systematic review and meta-analysis of perinatal variables in relation to testicular cancer risk, with a specific focus upon characteristics of the mother.Methods EMBASE, PubMed, Scopus and Web of Science databases were searched using sensitive search strategies. Meta-analysis was undertaken using STATA 10.Results A total of 5865 references were retrieved, of which 67 met the inclusion criteria and contributed data to at least one perinatal analysis. Random effects meta-analysis found maternal bleeding during pregnancy [odds ratio (OR) 1.33, 95% confidence interval (CI) 1.02-1.73], birth order (primiparous vs not, 1.08, 95% CI 1.01-1.16; second vs first, OR 0.94, 95% CI 0.88-0.99; third vs first, OR 0.91, 95% CI 0.83-1.01; fourth vs first, OR 0.80, 95% CI 0.69-0.94) and sibship size (2 vs 1, OR 0.93, 95% CI 0.75-1.15; 3 vs 1, OR 0.89, 95% CI 0.74-1.07; 4 vs 1, OR 0.75, 95% CI 0.62-0.90) to be associated with testicular cancer risk. Meta-analyses that produced summary estimates which indicated no association included maternal age, maternal nausea, maternal hypertension, pre-eclampsia, breech delivery and caesarean section. Meta-regression provided evidence that continent of study is important in the relationship between caesarean section and testicular cancer (P = 0.035), and a meta-analysis restricted to the three studies from the USA was suggestive of association (OR 1.67, 95% CI 1.07-2.56).Conclusions This systematic review and meta-analysis has found evidence for associations of maternal bleeding, birth order, sibship size and possibly caesarean section with risk of testicular cancer. JF - International Journal of Epidemiology AU - Cook, Michael B AU - Akre, Olof AU - Forman, David AU - Madigan, M Patricia AU - Richiardi, Lorenzo AU - McGlynn, Katherine A AD - super(2) Karolinska Institutet, Karolinska Sjukhuset, Stockholm, Sweden., michael.cook@nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1532 EP - 1542 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - 6 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - Epidemiology KW - meta-analysis KW - pregnancy KW - review, systematic KW - testicular neoplasms KW - USA KW - Age KW - Reviews KW - hypertension KW - Cancer KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21248701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=A+systematic+review+and+meta-analysis+of+perinatal+variables+in+relation+to+the+risk+of+testicular+cancer-experiences+of+the+mother&rft.au=Cook%2C+Michael+B%3BAkre%2C+Olof%3BForman%2C+David%3BMadigan%2C+M+Patricia%3BRichiardi%2C+Lorenzo%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2009-12-01&rft.volume=38&rft.issue=6&rft.spage=1532&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdyp287 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Reviews; hypertension; Cancer; Pregnancy; USA DO - http://dx.doi.org/10.1093/ije/dyp287 ER - TY - JOUR T1 - Should Prostate Specific Antigen be Adjusted for Body Mass Index? Data From the Baltimore Longitudinal Study of Aging AN - 21223439; 11266818 AB - Purpose - Obesity may be associated with lower prostate specific antigen through hemodilution. We examined the relationship between body mass index and prostate specific antigen by age in men without prostate cancer in a longitudinal aging study to determine whether prostate specific antigen must be adjusted for body mass index. Materials and Methods - The study population included 994 men (4,937 observations) without prostate cancer in the Baltimore Longitudinal Study of Aging. Mixed effects models were used to examine the relationship between prostate specific antigen and body mass index in kg/m super(2) by age. Separate models were explored in men with prostate cancer censored at diagnosis, for percent body fat measurements, for weight changes with time and adjusting for initial prostate size in 483 men (2,523 observations) with pelvic magnetic resonance imaging measurements. Results - In men without prostate cancer body mass index was not significantly associated with prostate specific antigen after adjusting for age (p = 0.06). A 10-point body mass index increase was associated with a prostate specific antigen difference of -0.03 ng/ml (95% CI -0.40-0.49). Results were similar when men with prostate cancer were included, when percent body fat was substituted for body mass index, and after adjusting for prostate volume. Longitudinal weight changes also had no significant association with prostate specific antigen. Conclusions - Consistent with prior studies, we found an inverse relationship between obesity and serum prostate specific antigen. However, the magnitude of the difference was small. Thus, adjusting prostate specific antigen for body mass index does not appear warranted. JF - Journal of Urology AU - Loeb, Stacy AU - Carter, HBallentine AU - Schaeffer, Edward M AU - Ferrucci, Luigi AU - Kettermann, Anna AU - Metter, EJeffrey AD - The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging (LF, EJM), National Institutes of Health Clinical Research Branch, Baltimore, Maryland, stacyloeb@gmail.com Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 2646 EP - 2652 PB - Elsevier Inc. VL - 182 IS - 6 SN - 0022-5347, 0022-5347 KW - Physical Education Index KW - prostate KW - prostatic neoplasms KW - prostate-specific antigen KW - obesity KW - hemodilution KW - Longitudinal studies KW - Measurement KW - Obesity KW - Blood KW - Weight KW - Men KW - Body mass KW - Observation KW - Cancer KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21223439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urology&rft.atitle=Should+Prostate+Specific+Antigen+be+Adjusted+for+Body+Mass+Index%3F+Data+From+the+Baltimore+Longitudinal+Study+of+Aging&rft.au=Loeb%2C+Stacy%3BCarter%2C+HBallentine%3BSchaeffer%2C+Edward+M%3BFerrucci%2C+Luigi%3BKettermann%2C+Anna%3BMetter%2C+EJeffrey&rft.aulast=Loeb&rft.aufirst=Stacy&rft.date=2009-12-01&rft.volume=182&rft.issue=6&rft.spage=2646&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urology&rft.issn=00225347&rft_id=info:doi/10.1016%2Fj.juro.2009.08.041 LA - English DB - Physical Education Index N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Blood; Obesity; Measurement; Weight; Men; Body mass; Observation; Cancer DO - http://dx.doi.org/10.1016/j.juro.2009.08.041 ER - TY - JOUR T1 - The Genetics of Preterm Birth: Using What We Know to Design Better Association Studies AN - 21195160; 11604617 AB - Women delivering preterm are at greatly increased risk of another preterm birth in subsequent pregnancies, reflecting effects of the environment, genetics, or both. Recent literature tells an increasingly coherent story about genetic susceptibility. Women who change partners after delivering preterm retain their elevated risk, whereas fathers who change partners do not. Women who themselves were preterm are at increased risk, an association not seen in fathers. Women with a half-sister who delivered preterm are at increased risk only if the shared parent was the mother. Concordance for preterm delivery is elevated in monozygotic compared with dizygotic twin mothers but not in monozygotic twin fathers. Several mechanisms could be operating: mitochondrial genes, maternal genes, or fetal genes expressing only the maternally derived copy. The authors compare 3 study designs for their ability to detect variants and to distinguish among mechanisms underlying heritability of this common outcome. The case-parent triad design offers robustness against self-selection and genetic population stratification, providing for estimation of genetic effects that are fetal, maternal, or that depend on the parent of origin. A case-base approach compares case-mothers with randomly sampled baby-mother pairs and permits estimation of the same relative risk parameters. Both designs offer important advantages over the commonly applied case-mother/control-mother design. JF - American Journal of Epidemiology AU - Weinberg, Clarice R AU - Shi, Min Y1 - 2009/12/01/ PY - 2009 DA - 2009 Dec 01 SP - 1373 EP - 1381 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 170 IS - 11 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Genetics Abstracts KW - Birth KW - Risk assessment KW - Population genetics KW - Twins KW - genetic effects KW - Mitochondria KW - Stratification KW - Fetuses KW - Heritability KW - Pregnancy KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21195160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=The+Genetics+of+Preterm+Birth%3A+Using+What+We+Know+to+Design+Better+Association+Studies&rft.au=Weinberg%2C+Clarice+R%3BShi%2C+Min&rft.aulast=Weinberg&rft.aufirst=Clarice&rft.date=2009-12-01&rft.volume=170&rft.issue=11&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp325 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Risk assessment; Birth; Population genetics; Twins; Mitochondria; Heritability; Fetuses; Pregnancy; genetic effects; Stratification DO - http://dx.doi.org/10.1093/aje/kwp325 ER - TY - JOUR T1 - Reliability, validity, and precision of an active stereophotogrammetry system for three-dimensional evaluation of the human torso AN - 21171977; 11355703 AB - To determine the reliability, stability, validity and precision of a stereophotogrammetry (SP) system for use in quantifying the complex three-dimensional structure of the human torso, we performed assessments of the system using images of geometric solids and a human-form mannequin. Analysis of geometric solids revealed excellent intra- and interrater reliability of the system for linear, surface area and volume measurements (r > 0.99, P 0.06). The system exhibited excellent stability in images of the mannequin over time (r > 0.99). The limit of precision (error > 5%) of the system to detect objects on the surface of the mannequin was estimated at an object size of 23.5 cm super(2) for surface area and 32 mL for volume. These results demonstrate the capability of SP of the torso to be used as a reliable, stable and valid measure of torso morphology to be applied as a clinical outcome tool in studies of bony and soft tissue pathologies such as scoliosis, rib deformities, obesity or edema. JF - Medical Engineering & Physics AU - Paul, Scott M AU - Chamberlin, Andrew P AU - Hatt, Charles AU - Nayak, Amritha V AU - Danoff, Jerome V AD - Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States, spaul@cc.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1337 EP - 1342 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 10 SN - 1350-4533, 1350-4533 KW - Biotechnology and Bioengineering Abstracts KW - Rib KW - Obesity KW - Scoliosis KW - Surface area KW - Edema KW - Soft tissues KW - Substance P KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21171977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Engineering+%26+Physics&rft.atitle=Reliability%2C+validity%2C+and+precision+of+an+active+stereophotogrammetry+system+for+three-dimensional+evaluation+of+the+human+torso&rft.au=Paul%2C+Scott+M%3BChamberlin%2C+Andrew+P%3BHatt%2C+Charles%3BNayak%2C+Amritha+V%3BDanoff%2C+Jerome+V&rft.aulast=Paul&rft.aufirst=Scott&rft.date=2009-12-01&rft.volume=31&rft.issue=10&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Medical+Engineering+%26+Physics&rft.issn=13504533&rft_id=info:doi/10.1016%2Fj.medengphy.2009.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Substance P; Surface area; Scoliosis; Soft tissues; Obesity; Rib; Edema DO - http://dx.doi.org/10.1016/j.medengphy.2009.08.011 ER - TY - JOUR T1 - Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting AN - 21157559; 11186422 AB - A key challenge in developing nanoplatform-based molecular imaging is to achieve an optimal pharmacokinetic profile to allow sufficient targeting and to avoid rapid clearance by the reticuloendothelial system (RES). In the present study, iron oxide nanoparticles (IONPs) were coated with a PEGylated amphiphilic triblock copolymer, making them water soluble and function-extendable. These particles were then conjugated with a near-infrared fluorescent (NIRF) dye IRDye800 and cyclic Arginine-Glycine-Aspartic acid (RGD) containing peptide c(RGDyK) for integrin alpha sub(v) beta sub(3) targeting. In vitro binding assays confirmed the integrin-specific association between the RGD-particle adducts and U87MG glioblastoma cells. Successful tumor homing in vivo was perceived in a subcutaneous U87MG glioblastoma xenograft model by both magnetic resonance imaging (MRI) and NIRF imaging. Ex vivo histopathological studies also revealed low particle accumulation in the liver, which was attributed to their compact hydrodynamic size and PEGylated coating. In conclusion, we have developed a novel RGD-IONP conjugate with excellent tumor integrin targeting efficiency and specificity as well as limited RES uptake for molecular MRI. JF - Biomaterials AU - Chen, K AU - Xie, J AU - Xu, H AU - Behera, D AU - Michalski, M H AU - Biswal, S AU - Wang, A AU - Chen, X AD - Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA, shawn.chen@nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 6912 EP - 6919 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 30 IS - 36 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Glioblastoma KW - I.R. radiation KW - Hydrodynamics KW - iron oxides KW - glioblastoma cells KW - Adducts KW - Magnetic resonance imaging KW - Tumors KW - Reticuloendothelial system KW - Pharmacokinetics KW - Integrins KW - Liver KW - Copolymers KW - Xenografts KW - nanoparticles KW - Coatings KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21157559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Triblock+copolymer+coated+iron+oxide+nanoparticle+conjugate+for+tumor+integrin+targeting&rft.au=Chen%2C+K%3BXie%2C+J%3BXu%2C+H%3BBehera%2C+D%3BMichalski%2C+M+H%3BBiswal%2C+S%3BWang%2C+A%3BChen%2C+X&rft.aulast=Chen&rft.aufirst=K&rft.date=2009-12-01&rft.volume=30&rft.issue=36&rft.spage=6912&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2009.08.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Glioblastoma; I.R. radiation; iron oxides; Hydrodynamics; Adducts; glioblastoma cells; Magnetic resonance imaging; Tumors; Reticuloendothelial system; Pharmacokinetics; Integrins; Copolymers; Liver; Xenografts; nanoparticles; Coatings DO - http://dx.doi.org/10.1016/j.biomaterials.2009.08.045 ER - TY - JOUR T1 - Clinical Use of Interferon- gamma AN - 1780517316; PQ0002828615 AB - Interferon gamma (IFN- gamma ), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN- gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN- gamma has been used in a wide variety of clinical indications, which are reviewed in this article. JF - Annals of the New York Academy of Sciences AU - Miller, Catriona HT AU - Maher, Stephen G AU - Young, Howard A AD - Center for Cancer Research, Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, Maryland, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 69 EP - 79 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 1182 IS - 1 SN - 0077-8923, 0077-8923 KW - Immunology Abstracts; Environment Abstracts KW - Pharmacology KW - Reviews KW - Clinical trials KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780517316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Clinical+Use+of+Interferon-+gamma&rft.au=Miller%2C+Catriona+HT%3BMaher%2C+Stephen+G%3BYoung%2C+Howard+A&rft.aulast=Miller&rft.aufirst=Catriona&rft.date=2009-12-01&rft.volume=1182&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.05069.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Pharmacology; Reviews; Clinical trials DO - http://dx.doi.org/10.1111/j.1749-6632.2009.05069.x ER - TY - CPAPER T1 - Building a Sustainable Bioinformatics Program: Opportunities and Challenges T2 - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AN - 42247016; 5598150 JF - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AU - Tartakovsky, Mike AU - Huyen, Yentram Y1 - 2009/11/30/ PY - 2009 DA - 2009 Nov 30 KW - Sustainable development KW - Bioinformatics KW - Computer programs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42247016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.atitle=Building+a+Sustainable+Bioinformatics+Program%3A+Opportunities+and+Challenges&rft.au=Tartakovsky%2C+Mike%3BHuyen%2C+Yentram&rft.aulast=Tartakovsky&rft.aufirst=Mike&rft.date=2009-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/africa09/Africa09-Preliminar y-ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systems-level analysis of spatial constraints in biological networks using NetCirChro T2 - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AN - 42243357; 5598161 JF - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AU - Huyen, Yentram Y1 - 2009/11/30/ PY - 2009 DA - 2009 Nov 30 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42243357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.atitle=Systems-level+analysis+of+spatial+constraints+in+biological+networks+using+NetCirChro&rft.au=Huyen%2C+Yentram&rft.aulast=Huyen&rft.aufirst=Yentram&rft.date=2009-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/africa09/Africa09-Preliminar y-ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engaging African Scientists in the Genomic Revolution to Ensure that Tomorrow's Biotechnology and Medicine will Work for African People T2 - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AN - 42241626; 5598145 JF - Joint ISCB Africa ASBCB Conference on Bioinformatics of Infectious Diseases AU - Rotimi, Charles Y1 - 2009/11/30/ PY - 2009 DA - 2009 Nov 30 KW - Africa KW - Biotechnology KW - Genomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42241626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.atitle=Engaging+African+Scientists+in+the+Genomic+Revolution+to+Ensure+that+Tomorrow%27s+Biotechnology+and+Medicine+will+Work+for+African+People&rft.au=Rotimi%2C+Charles&rft.aulast=Rotimi&rft.aufirst=Charles&rft.date=2009-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+ISCB+Africa+ASBCB+Conference+on+Bioinformatics+of+Infectious+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/africa09/Africa09-Preliminar y-ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating the Roles of Mucin-Type O-Glycosylation During Eukaryotic Development T2 - 20th International Symposium of Glycoconjugates (GLYCO XX) AN - 42243070; 5597834 JF - 20th International Symposium of Glycoconjugates (GLYCO XX) AU - Ten Hagen, Kelly AU - Zhang, Liping AU - Tran, Duy AU - Tian, E AU - Xuefeng, Zhang Y1 - 2009/11/29/ PY - 2009 DA - 2009 Nov 29 KW - Glycosylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42243070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.atitle=Investigating+the+Roles+of+Mucin-Type+O-Glycosylation+During+Eukaryotic+Development&rft.au=Ten+Hagen%2C+Kelly%3BZhang%2C+Liping%3BTran%2C+Duy%3BTian%2C+E%3BXuefeng%2C+Zhang&rft.aulast=Ten+Hagen&rft.aufirst=Kelly&rft.date=2009-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glyco20.org/pdfs/ScientifciProgramUpdate.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Glycomics to Target Therapeutic Enzymes T2 - 20th International Symposium of Glycoconjugates (GLYCO XX) AN - 42239398; 5597738 JF - 20th International Symposium of Glycoconjugates (GLYCO XX) AU - Brady, Roscoe Y1 - 2009/11/29/ PY - 2009 DA - 2009 Nov 29 KW - Enzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42239398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.atitle=Use+of+Glycomics+to+Target+Therapeutic+Enzymes&rft.au=Brady%2C+Roscoe&rft.aulast=Brady&rft.aufirst=Roscoe&rft.date=2009-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glyco20.org/pdfs/ScientifciProgramUpdate.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shigella O-specific oligosaccharide-core-protein conjugates: new vaccine candidates T2 - 20th International Symposium of Glycoconjugates (GLYCO XX) AN - 42232906; 5597753 JF - 20th International Symposium of Glycoconjugates (GLYCO XX) AU - Kubler-Kielb, Joanna AU - Vinogradov, Evgeny AU - Mocca, Christopher AU - Guo, Chunyan AU - Robbins, John AU - Schneerson, Rachel Y1 - 2009/11/29/ PY - 2009 DA - 2009 Nov 29 KW - Vaccines KW - Disease control KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42232906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.atitle=Shigella+O-specific+oligosaccharide-core-protein+conjugates%3A+new+vaccine+candidates&rft.au=Kubler-Kielb%2C+Joanna%3BVinogradov%2C+Evgeny%3BMocca%2C+Christopher%3BGuo%2C+Chunyan%3BRobbins%2C+John%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2009-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glyco20.org/pdfs/ScientifciProgramUpdate.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure-Function Studies and Design of Novel Glycosyltransferases for Site Specific Bioconjugation of mAbs and scFv via Glycan residues: Development of a Targeted Drug Delivery System and Contrast Agents for MRI T2 - 20th International Symposium of Glycoconjugates (GLYCO XX) AN - 42230081; 5597933 JF - 20th International Symposium of Glycoconjugates (GLYCO XX) AU - Qasba, Pradman AU - Ramakrishnan, Boopathy AU - Boeggeman, Elizabeth AU - Pasek, Marta AU - Manzoni, Maria Y1 - 2009/11/29/ PY - 2009 DA - 2009 Nov 29 KW - Residues KW - Drug delivery KW - Drug development KW - Monoclonal antibodies KW - Magnetic resonance imaging KW - Glycosyltransferase KW - Contrast media KW - Polysaccharides KW - Fv KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42230081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.atitle=Structure-Function+Studies+and+Design+of+Novel+Glycosyltransferases+for+Site+Specific+Bioconjugation+of+mAbs+and+scFv+via+Glycan+residues%3A+Development+of+a+Targeted+Drug+Delivery+System+and+Contrast+Agents+for+MRI&rft.au=Qasba%2C+Pradman%3BRamakrishnan%2C+Boopathy%3BBoeggeman%2C+Elizabeth%3BPasek%2C+Marta%3BManzoni%2C+Maria&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2009-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glyco20.org/pdfs/ScientifciProgramUpdate.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and characterization of second order sacral neurons involved in activation of the hindlimb central pattern generator in the neonatal rodent spinal cord T2 - 18th Annual Meeting of the Israel Society for Neuroscience AN - 42278371; 5619426 JF - 18th Annual Meeting of the Israel Society for Neuroscience AU - Blivis, D AU - Mentis, G AU - O`Donovan, M AU - Lev-Tov, A Y1 - 2009/11/22/ PY - 2009 DA - 2009 Nov 22 KW - Neonates KW - Rodents KW - Spinal cord KW - Central pattern generator KW - Sacrum KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42278371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.atitle=Identification+and+characterization+of+second+order+sacral+neurons+involved+in+activation+of+the+hindlimb+central+pattern+generator+in+the+neonatal+rodent+spinal+cord&rft.au=Blivis%2C+D%3BMentis%2C+G%3BO%60Donovan%2C+M%3BLev-Tov%2C+A&rft.aulast=Blivis&rft.aufirst=D&rft.date=2009-11-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.isfn.org.il/admin/AnnualBar/images/6706672.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of Toll-like Receptors in CNS plasticity T2 - 18th Annual Meeting of the Israel Society for Neuroscience AN - 42277873; 5619653 JF - 18th Annual Meeting of the Israel Society for Neuroscience AU - Okun, E AU - Griffioen, K AU - Roberts, N AU - Castro, K AU - Mattson, M AU - Barak, B Y1 - 2009/11/22/ PY - 2009 DA - 2009 Nov 22 KW - Plasticity KW - Central nervous system KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42277873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.atitle=Involvement+of+Toll-like+Receptors+in+CNS+plasticity&rft.au=Okun%2C+E%3BGriffioen%2C+K%3BRoberts%2C+N%3BCastro%2C+K%3BMattson%2C+M%3BBarak%2C+B&rft.aulast=Okun&rft.aufirst=E&rft.date=2009-11-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.isfn.org.il/admin/AnnualBar/images/6706672.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spontaneous activity in the developing nervous system: Mechanisms and Functions T2 - 18th Annual Meeting of the Israel Society for Neuroscience AN - 42272771; 5619486 JF - 18th Annual Meeting of the Israel Society for Neuroscience AU - O'Donovan, M Y1 - 2009/11/22/ PY - 2009 DA - 2009 Nov 22 KW - Nervous system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42272771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.atitle=Spontaneous+activity+in+the+developing+nervous+system%3A+Mechanisms+and+Functions&rft.au=O%27Donovan%2C+M&rft.aulast=O%27Donovan&rft.aufirst=M&rft.date=2009-11-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Israel+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.isfn.org.il/admin/AnnualBar/images/6706672.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis. AN - 733862010; 19865736 AB - A Lab-on-a-chip (LOC) was designed, fabricated and tested for the in vitro detection of botulinum neurotoxin serotype A (BoNT-A) activity using an assay that measures cleavage of a fluorophore-tagged peptide substrate specific for BoNT-A (SNAP-25) by the toxin light chain (LcA). LcA cleavage was detected by Förster Resonance Energy Transfer (FRET) fluorescence. FRET fluorescence was measured by a newly developed portable charge-coupled device (CCD) fluorescent detector equipped with multi-wavelength light-emitting diodes (LED) illumination. An eight V-junction microchannel device for BoNTs activity assays was constructed using Laminated Object Manufacturing (LOM) technology. The six-layer device was fabricated with a Poly(methyl methacrylate (PMMA) core and five polycarbonate (PC) layers micromachined by CO2 laser. The LOC is operated by syringe and is equipped with reagents, sample wells, reaction wells, diffusion traps (to avoid cross contamination among channels) and waste reservoirs. The system was detected LcA at concentrations as low as 0.5 nM, which is the reported sensitivity of the SNAP-25 in vitro cleavage assay. Combined with our CCD detector, the simple point of care system enables the detection of BoNTs activity and may be useful for the performance of other complex medical assays without a laboratory. This approach may realize the potential to enhance the quality of health care delivery for underserved populations. JF - Lab on a chip AU - Sun, Steven AU - Ossandon, Miguel AU - Kostov, Yordan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering Laboratories, FDA, NIH/NCI, Silver Spring, MD 20993, USA. Y1 - 2009/11/21/ PY - 2009 DA - 2009 Nov 21 SP - 3275 EP - 3281 VL - 9 IS - 22 SN - 1473-0197, 1473-0197 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Fluorescence Resonance Energy Transfer KW - Lab-On-A-Chip Devices KW - Botulinum Toxins, Type A -- analysis KW - Microchip Analytical Procedures -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733862010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lab+on+a+chip&rft.atitle=Lab-on-a-chip+for+botulinum+neurotoxin+a+%28BoNT-A%29+activity+analysis.&rft.au=Sun%2C+Steven%3BOssandon%2C+Miguel%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Sun&rft.aufirst=Steven&rft.date=2009-11-21&rft.volume=9&rft.issue=22&rft.spage=3275&rft.isbn=&rft.btitle=&rft.title=Lab+on+a+chip&rft.issn=14730197&rft_id=info:doi/10.1039%2Fb912097a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-29 N1 - Date created - 2009-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1992 Oct;11(10):3577-83 [1396558] Microbiol Rev. 1992 Mar;56(1):80-99 [1579114] Nature. 1993 Sep 9;365(6442):160-3 [8103915] Cell. 1993 Oct 8;75(1):1-4 [8402889] Eur J Biochem. 1993 Nov 1;217(3):965-71 [8223654] J Biol Chem. 1993 Nov 15;268(32):23784-7 [8226912] J Physiol Paris. 1993;87(2):107-15 [8305898] Electrophoresis. 1999 Apr-May;20(4-5):727-31 [10344240] Appl Environ Microbiol. 2005 Jul;71(7):3935-41 [16000807] J Immunol Methods. 2005 Jun;301(1-2):164-72 [15979637] Croat Med J. 2005 Aug;46(4):491-7 [16100750] Biomed Microdevices. 2005 Sep;7(3):205-11 [16133808] Methods. 2005 Sep;37(1):65-72 [16202623] J Appl Toxicol. 1999 Dec;19 Suppl 1:S13-7 [10594893] Electrophoresis. 2002 Mar;23(6):858-67 [11920870] Anal Chem. 2002 Apr 15;74(8):1798-804 [11985310] J Immunol Methods. 2002 May 1;263(1-2):35-41 [12009202] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11346-50 [12177434] Anal Bioanal Chem. 2003 Oct;377(3):469-77 [12811462] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13621-5 [14573702] J Food Prot. 2004 Jan;67(1):203-6 [14717376] Lab Chip. 2003 Nov;3(4):248-52 [15007454] Lab Chip. 2004 Oct;4(5):438-45 [15472727] Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14701-6 [15465919] Emerg Infect Dis. 2005 Oct;11(10):1578-83 [16318699] Appl Environ Microbiol. 2005 Dec;71(12):7897-903 [16332765] J Biomol Screen. 2005 Dec;10(8):788-94 [16234350] Appl Environ Microbiol. 2006 Feb;72(2):1231-8 [16461671] Anal Biochem. 2006 Apr 1;351(1):84-92 [16500606] Anal Biochem. 2006 Jun 15;353(2):248-56 [16620745] J Comb Chem. 2006 Jul-Aug;8(4):513-21 [16827563] Nature. 2006 Jul 27;442(7101):412-8 [16871209] Diagn Microbiol Infect Dis. 2006 Nov;56(3):225-32 [16839735] Anal Sci. 2007 Jan;23(1):5-10 [17213615] Diagn Microbiol Infect Dis. 2007 Mar;57(3):243-9 [17141460] Anal Chim Acta. 2007 Mar 21;587(1):1-8 [17386746] Crit Rev Microbiol. 2007 Apr-Jun;33(2):109-25 [17558660] J Vet Diagn Invest. 2007 Jul;19(4):349-54 [17609342] J Immunol Methods. 2007 Aug 31;325(1-2):78-87 [17659299] Nature. 2007 Dec 20;450(7173):1235-9 [18097410] Appl Environ Microbiol. 2008 Feb;74(3):653-9 [18083881] Appl Environ Microbiol. 2008 Jul;74(14):4309-13 [18515481] Int J Food Microbiol. 2008 Aug 15;126(1-2):135-9 [18571757] Biosens Bioelectron. 2008 Dec 1;24(4):618-25 [18644709] Lab Chip. 2008 Nov;8(11):1793-800 [18941677] Protein Pept Lett. 2008;15(10):1100-6 [19075822] Anal Bioanal Chem. 2009 May;394(2):499-505 [19290511] Biomed Microdevices. 2009 Aug;11(4):883-92 [19387837] J Chromatogr A. 2009 Nov 20;1216(47):8289-95 [19497576] Lancet. 1990 Feb 17;335(8686):421 [1968156] Nature. 1992 Oct 29;359(6398):832-5 [1331807] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b912097a ER - TY - CPAPER T1 - Control of regulatory T cells by commensals T2 - 38th Autumn Immunology Conference (AIC 2009) AN - 42226311; 5593606 JF - 38th Autumn Immunology Conference (AIC 2009) AU - Belkaid, Yasmine Y1 - 2009/11/20/ PY - 2009 DA - 2009 Nov 20 KW - Lymphocytes T KW - Immunoregulation KW - Commensals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=38th+Autumn+Immunology+Conference+%28AIC+2009%29&rft.atitle=Control+of+regulatory+T+cells+by+commensals&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2009-11-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=38th+Autumn+Immunology+Conference+%28AIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.flip-programs.com/AIC/2009_Program/files/aic2009booklet.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Who Owns What? Private Ownership and the Public Interest in Recombinant DNA Technology in the 1970s T2 - 2009 Annual Meeting of the History of Science Society (HSS 2009) AN - 42183386; 5568038 JF - 2009 Annual Meeting of the History of Science Society (HSS 2009) AU - Yi, Doogab Y1 - 2009/11/19/ PY - 2009 DA - 2009 Nov 19 KW - Public concern KW - Technology KW - Property rights KW - Recombinants KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42183386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+History+of+Science+Society+%28HSS+2009%29&rft.atitle=Who+Owns+What%3F+Private+Ownership+and+the+Public+Interest+in+Recombinant+DNA+Technology+in+the+1970s&rft.au=Yi%2C+Doogab&rft.aulast=Yi&rft.aufirst=Doogab&rft.date=2009-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+History+of+Science+Society+%28HSS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hssonline.org/images/Meetings/2009HSSProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coronary Artery Disease and the Consolidation of Medical Authority T2 - 2009 Annual Meeting of the History of Science Society (HSS 2009) AN - 42181605; 5567982 JF - 2009 Annual Meeting of the History of Science Society (HSS 2009) AU - Olszewski, Todd Y1 - 2009/11/19/ PY - 2009 DA - 2009 Nov 19 KW - Heart diseases KW - Consolidation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42181605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+History+of+Science+Society+%28HSS+2009%29&rft.atitle=Coronary+Artery+Disease+and+the+Consolidation+of+Medical+Authority&rft.au=Olszewski%2C+Todd&rft.aulast=Olszewski&rft.aufirst=Todd&rft.date=2009-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+History+of+Science+Society+%28HSS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hssonline.org/images/Meetings/2009HSSProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tocqueville's Geopolitics T2 - 2009 Annual Meeting of the Northeastern Political Science Association AN - 42174716; 5569608 JF - 2009 Annual Meeting of the Northeastern Political Science Association AU - Crowe, Samuel Y1 - 2009/11/19/ PY - 2009 DA - 2009 Nov 19 KW - Geopolitics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42174716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Northeastern+Political+Science+Association&rft.atitle=Tocqueville%27s+Geopolitics&rft.au=Crowe%2C+Samuel&rft.aulast=Crowe&rft.aufirst=Samuel&rft.date=2009-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Northeastern+Political+Science+Association&rft.issn=&rft_id=info:doi/ L2 - http://convention2.allacademic.com/one/npsa/npsa09/index.php?click_key =2&cmd=Multi+Search+View+Program+Load+Scheduled+Times&schedule_day=2 009-11-21+00%3A00%3A00&PHPSESSID=08b38af74744c48ba708e735fb5a9965 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Federal & Foundation Funding Sources: Research Grants & Training Grants T2 - 2009 Convention of the American Speech-Language-Hearing Association (ASHA 2009) AN - 42161711; 5559658 JF - 2009 Convention of the American Speech-Language-Hearing Association (ASHA 2009) AU - Lana, Shekim AU - Leddy, Mark AU - Wilcox, Jeanne AU - Howard, Goldstein AU - Justice, Laura AU - Minghetti, Nancy Y1 - 2009/11/19/ PY - 2009 DA - 2009 Nov 19 KW - Grants KW - Training KW - Foundations KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42161711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Convention+of+the+American+Speech-Language-Hearing+Association+%28ASHA+2009%29&rft.atitle=Federal+%26amp%3B+Foundation+Funding+Sources%3A+Research+Grants+%26amp%3B+Training+Grants&rft.au=Lana%2C+Shekim%3BLeddy%2C+Mark%3BWilcox%2C+Jeanne%3BHoward%2C+Goldstein%3BJustice%2C+Laura%3BMinghetti%2C+Nancy&rft.aulast=Lana&rft.aufirst=Shekim&rft.date=2009-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Convention+of+the+American+Speech-Language-Hearing+Association+%28ASHA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/nxtbooks/asha/2009confprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NIH Grant Review Process: A Mock Review Panel T2 - 2009 Convention of the American Speech-Language-Hearing Association (ASHA 2009) AN - 42154999; 5559091 JF - 2009 Convention of the American Speech-Language-Hearing Association (ASHA 2009) AU - Moore, Christopher Y1 - 2009/11/19/ PY - 2009 DA - 2009 Nov 19 KW - Reviews KW - Grants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42154999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Convention+of+the+American+Speech-Language-Hearing+Association+%28ASHA+2009%29&rft.atitle=The+NIH+Grant+Review+Process%3A+A+Mock+Review+Panel&rft.au=Moore%2C+Christopher&rft.aulast=Moore&rft.aufirst=Christopher&rft.date=2009-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Convention+of+the+American+Speech-Language-Hearing+Association+%28ASHA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/nxtbooks/asha/2009confprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Putting Risk Prediction in Perspective: Relative Utility Curves AN - 954580648; 13761812 AB - Risk prediction models based on medical history or results of tests are increasingly common in the cancer literature. An important use of these models is to make treatment decisions on the basis of estimated risk. The relative utility curve is a simple method for evaluating risk prediction in a medical decision-making framework. Relative utility curves have three attractive features for the evaluation of risk prediction models. First, they put risk prediction into perspective because relative utility is the fraction of the expected utility of perfect prediction obtained by the risk prediction model at the optimal cut point. Second, they do not require precise specification of harms and benefits because relative utility is plotted against a summary measure of harms and benefits (ie, the risk threshold). Third, they are easy to compute from standard tables of data found in many articles on risk prediction. An important use of relative utility curves is to evaluate the addition of a risk factor to the risk prediction model. To illustrate an application of relative utility curves, an analysis was performed on previously published data involving the addition of breast density to a risk prediction model for invasive breast cancer. JF - Journal of the National Cancer Institute AU - Baker, Stuart G AD - Affiliation of author: Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, sb16i@nih.gov Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 SP - 1538 EP - 1542 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Historical account KW - prediction models KW - Breast cancer KW - expected utility theory KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954580648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Putting+Risk+Prediction+in+Perspective%3A+Relative+Utility+Curves&rft.au=Baker%2C+Stuart+G&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2009-11-18&rft.volume=101&rft.issue=22&rft.spage=1538&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp353 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; prediction models; Breast cancer; expected utility theory; Cancer DO - http://dx.doi.org/10.1093/jnci/djp353 ER - TY - JOUR T1 - A Case-Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over Time AN - 899130172; 13761815 AB - Background Cigarette smoking is a well-established risk factor for bladder cancer. The effects of smoking duration, intensity (cigarettes per day), and total exposure (pack-years); smoking cessation; exposure to environmental tobacco smoke; and changes in the composition of tobacco and cigarette design over time on risk of bladder cancer are unclear. Methods We examined bladder cancer risk in relation to smoking practices based on interview data from a large, population-based case-control study conducted in Maine, New Hampshire, and Vermont from 2001 to 2004 (N = 1170 urothelial carcinoma case patients and 1413 control subjects). We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression. To examine changes in smoking-induced bladder cancer risk over time, we compared odds ratios from New Hampshire residents in this study (305 case patients and 335 control subjects) with those from two case-control studies conducted in New Hampshire in 1994-1998 and in 1998-2001 (843 case patients and 1183 control subjects). Results Regular and current cigarette smokers had higher risks of bladder cancer than never-smokers (for regular smokers, OR = 3.0, 95% CI = 2.4 to 3.6; for current smokers, OR = 5.2, 95% CI = 4.0 to 6.6). In New Hampshire, there was a statistically significant increasing trend in smoking-related bladder cancer risk over three consecutive periods (1994-1998, 1998-2001, and 2002-2004) among former smokers (OR = 1.4, 95% CI = 1.0 to 2.0; OR = 2.0, 95% CI = 1.4 to 2.9; and OR = 2.6, 95% CI = 1.7 to 4.0, respectively) and current smokers (OR = 2.9, 95% CI = 2.0 to 4.2; OR = 4.2, 95% CI = 2.8 to 6.3; OR = 5.5, 95% CI = 3.5 to 8.9, respectively) (P for homogeneity of trends over time periods = .04). We also observed that within categories of intensity, odds ratios increased approximately linearly with increasing pack-years smoked, but the slope of the increasing trend declined with increasing intensity. Conclusions Smoking-related risks of bladder cancer appear to have increased in New Hampshire since the mid-1990s. Based on our modeling of pack-years and intensity, smoking fewer cigarettes over a long time appears more harmful than smoking more cigarettes over a shorter time, for equal total pack-years of cigarettes smoked. JF - Journal of the National Cancer Institute AU - Baris, Dalsu AU - Karagas, Margaret R AU - Verrill, Castine AU - Johnson, Alison AU - Andrew, Angeline S AU - Marsit, Carmen J AU - Schwenn, Molly AU - Colt, Joanne S AU - Cherala, Sai AU - Samanic, Claudine AU - Waddell, Richard AU - Cantor, Kenneth P AU - Schned, Alan AU - Rothman, Nathaniel AU - Lubin, Jay AU - Fraumeni, Joseph F AU - Hoover, Robert N AU - Kelsey, Karl T AU - Silverman, Debra T AD - Affiliations of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DB, JSC, KPC, NR, CS, JL, JFF, RNH, DTS); Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH (MRK, ASA, RW, AS); Department of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island (CJM, KTK); Maine Cancer Registry, Augusta, ME (CV, MS); New Hampshire Cancer Registry, Concord, NH (SC); Vermont Cancer Registry, Burlington, VT (AJ), barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 SP - 1553 EP - 1561 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Cigarettes KW - Cancer KW - urinary bladder KW - Passive smoking KW - Cigarette smoking KW - Tobacco KW - USA, Maine KW - USA, New Hampshire KW - USA, Vermont KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899130172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=A+Case-Control+Study+of+Smoking+and+Bladder+Cancer+Risk%3A+Emergent+Patterns+Over+Time&rft.au=Baris%2C+Dalsu%3BKaragas%2C+Margaret+R%3BVerrill%2C+Castine%3BJohnson%2C+Alison%3BAndrew%2C+Angeline+S%3BMarsit%2C+Carmen+J%3BSchwenn%2C+Molly%3BColt%2C+Joanne+S%3BCherala%2C+Sai%3BSamanic%2C+Claudine%3BWaddell%2C+Richard%3BCantor%2C+Kenneth+P%3BSchned%2C+Alan%3BRothman%2C+Nathaniel%3BLubin%2C+Jay%3BFraumeni%2C+Joseph+F%3BHoover%2C+Robert+N%3BKelsey%2C+Karl+T%3BSilverman%2C+Debra+T&rft.aulast=Baris&rft.aufirst=Dalsu&rft.date=2009-11-18&rft.volume=101&rft.issue=22&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp361 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - urinary bladder; Passive smoking; Cigarettes; Cigarette smoking; Tobacco; Cancer; USA, Maine; USA, New Hampshire; USA, Vermont DO - http://dx.doi.org/10.1093/jnci/djp361 ER - TY - JOUR T1 - Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. AN - 734135360; 19856962 AB - Carbohydrate binding proteins, or lectins, are engendered with the ability to bind specific carbohydrate structures, thereby mediating cell-cell and cell-pathogen interactions. Lectins are distinct from carbohydrate modifying enzymes and antibodies, respectively, as they do not carry out glycosidase or glycosyl transferase reactions, and they are of nonimmune origin. Cyanobacterial and algal lectins have become prominent in recent years due to their unique biophysical traits, such as exhibiting novel protein folds and unusually high carbohydrate affinity, and ability to potently inhibit HIV-1 entry through high affinity carbohydrate-mediated interactions with the HIV envelope glycoprotein gp120. The antiviral cyanobacterial lectin Microcystis viridis lectin (MVL), which contains two high affinity oligomannose binding sites, is one such example. Here we used glycan microarray profiling, NMR spectroscopy, and mutagenesis to show that one of the two oligomannose binding sites of MVL can catalyze the cleavage of chitin fragments (such as chitotriose) to GlcNAc, to determine the mode of MVL binding to and cleavage of chitotriose, to identify Asp75 as the primary catalytic residue involved in this cleavage, and to solve the solution structure of an inactive mutant of MVL in complex with this unexpected substrate. These studies represent the first demonstration of dual catalytic activity and carbohydrate recognition for discrete oligosaccharides at the same carbohydrate-binding site in a lectin. Sequence comparisons between the N- and C-domains of MVL, together with the sequences of new MVL homologues identified through bioinformatics, provide insight into the evolving roles of carbohydrate recognition. JF - Journal of the American Chemical Society AU - Shahzad-ul-Hussan, Syed AU - Cai, Mengli AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 SP - 16500 EP - 16508 VL - 131 IS - 45 KW - Carbohydrates KW - 0 KW - Lectins KW - Glycoside Hydrolases KW - EC 3.2.1.- KW - Index Medicus KW - Models, Molecular KW - Molecular Sequence Data KW - Catalysis KW - Carbohydrate Conformation KW - Binding Sites KW - Glycoside Hydrolases -- chemistry KW - Microcystis -- chemistry KW - Glycoside Hydrolases -- metabolism KW - Carbohydrates -- chemistry KW - Lectins -- chemistry KW - Lectins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734135360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Unprecedented+glycosidase+activity+at+a+lectin+carbohydrate-binding+site+exemplified+by+the+cyanobacterial+lectin+MVL.&rft.au=Shahzad-ul-Hussan%2C+Syed%3BCai%2C+Mengli%3BBewley%2C+Carole+A&rft.aulast=Shahzad-ul-Hussan&rft.aufirst=Syed&rft.date=2009-11-18&rft.volume=131&rft.issue=45&rft.spage=16500&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja905929c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-12 N1 - Date created - 2009-11-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Chem Soc. 2001 Jun 27;123(25):6108-17 [11414845] Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104 [19332801] Structure. 2001 Oct;9(10):931-40 [11591348] Science. 2002 Jun 21;296(5576):2183-5 [12077404] Cancer Metastasis Rev. 2001;20(3-4):245-77 [12085965] Glycobiology. 2002 Jun;12(6):79R-105R [12107077] Nat Struct Biol. 2002 Sep;9(9):653-8 [12161746] J Biol Chem. 2002 Sep 13;277(37):34336-42 [12110688] J Magn Reson. 2003 Jan;160(1):65-73 [12565051] Biochemistry. 2003 Mar 11;42(9):2578-84 [12614152] Cancer Sci. 2004 May;95(5):377-84 [15132763] J Mol Biol. 2004 Jun 11;339(4):901-14 [15165858] Annu Rev Biochem. 1986;55:35-67 [3527046] Methods Enzymol. 1994;239:349-63 [7830590] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Antimicrob Agents Chemother. 1997 Jul;41(7):1521-30 [9210678] Cell. 1999 Apr 30;97(3):361-9 [10319816] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17033-8 [15563589] J Virol. 2005 Aug;79(16):10108-25 [16051804] J Biol Chem. 2005 Aug 12;280(32):29269-76 [15937331] Proteins. 2005 Sep 1;60(4):670-8 [16003744] Mol Microbiol. 2006 Feb;59(3):893-906 [16420359] Nat Chem Biol. 2006 Mar;2(3):153-7 [16462751] J Biol Chem. 2007 Apr 13;282(15):11021-9 [17314091] Protein Sci. 2007 Jul;16(7):1485-9 [17567736] Biochem Biophys Res Commun. 1999 Nov 30;265(3):703-8 [10600484] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9021-5 [10922057] Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10231-5 [10963683] Science. 2001 Mar 23;291(5512):2357-64 [11269316] Cell Mol Life Sci. 2007 Jul;64(14):1805-23 [17447007] Mol Biosyst. 2008 Jun;4(6):654-62 [18493664] Biochemistry. 2008 Sep 2;47(35):9145-53 [18690703] Bioorg Med Chem. 2008 Dec 1;16(23):10113-20 [18952441] Nat Chem Biol. 2009 Apr;5(4):244-50 [19234452] J Am Chem Soc. 2001 Feb 7;123(5):1014-5 [11456652] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja905929c ER - TY - CPAPER T1 - Structural and Biochemical Characterization of the Binding Region of Plasmodium Falciparum var2csa dbl3x with Chondroitin Sulfate A T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42239045; 5591507 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Singh, Kavita AU - Gitti, Rossitza AU - Gittis, Apostolos AU - Nguyen, Phuc AU - Mohan, Michael AU - Gowda, Channe AU - Tullo, Gregory AU - Zhou, Hong AU - Fairhurst, Rick AU - Long, Carole AU - Garboczi, David Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Sulfate KW - Biochemistry KW - Chondroitin sulfate KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42239045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+rheumatology+reports&rft.atitle=Genetic+risk+and+protective+factors+for+the+idiopathic+inflammatory+myopathies.&rft.au=O%27Hanlon%2C+Terrance+P%3BMiller%2C+Frederick+W&rft.aulast=O%27Hanlon&rft.aufirst=Terrance&rft.date=2009-08-01&rft.volume=11&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Current+rheumatology+reports&rft.issn=1534-6307&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Mapping in Two P. Falciparum Crosses Identifies a Locus Encoding the Plasmodial Surface Anion Channel T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42238725; 5591503 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Bokhari, Abdullah AU - Desai, Sanjay Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Anion channels KW - Gene mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42238725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Genetic+Mapping+in+Two+P.+Falciparum+Crosses+Identifies+a+Locus+Encoding+the+Plasmodial+Surface+Anion+Channel&rft.au=Bokhari%2C+Abdullah%3BDesai%2C+Sanjay&rft.aulast=Bokhari&rft.aufirst=Abdullah&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antibody Levels to ama1 and msp142 in Malian Infants T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42233935; 5591757 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Ellis, Ruth AU - Sissoko, Mahamadou AU - Assadou, Mahamadoun AU - Guindo, Merapen AU - Saye, Renion AU - Kone, Mamady AU - Kante, Ousmane AU - Kamate, Beh AU - Guindo, Ousmane AU - Sagara, Issaka AU - Dicko, Alassane AU - Imeru, Alemush AU - Fay, Michael AU - Pierce, Mark AU - Miller, Louis AU - Miura, Kazutoyo AU - Diallo, Dapa AU - Doumbo, Ogobara Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Infants KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42233935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Pharmaceutical+Design&rft.atitle=Recombinant+Immunotoxins+for+the+Treatment+of+Chemoresistant+Hematologic+Malignancies&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-08-01&rft.volume=15&rft.issue=23&rft.spage=2652&rft.isbn=&rft.btitle=&rft.title=Current+Pharmaceutical+Design&rft.issn=13816128&rft_id=info:doi/10.2174%2F138161209788923949 L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Validation of the Plasmodial Surface Anion Channel as an Antimalarial Drug Target T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42233820; 5591479 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Pillai, Ajay AU - Desai, Sanjay Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Anion channels KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42233820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Genetic+Validation+of+the+Plasmodial+Surface+Anion+Channel+as+an+Antimalarial+Drug+Target&rft.au=Pillai%2C+Ajay%3BDesai%2C+Sanjay&rft.aulast=Pillai&rft.aufirst=Ajay&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Growth Inhibitory Antibodies against Bloodstage P. Falciparum T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42233443; 5591868 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Long, Carole Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Antibodies KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42233443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Growth+Inhibitory+Antibodies+against+Bloodstage+P.+Falciparum&rft.au=Long%2C+Carole&rft.aulast=Long&rft.aufirst=Carole&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Rat Model of Intracerebral Infection with Taenia Crassiceps for the Study of Inflammation Associated with Anthelmintic Therapy in Neurocysticercosis T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42232441; 5591407 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Mahanty, Siddhartha AU - Berns, Abby AU - Scott, Erick AU - Lizak, Martin AU - Nash, Theodore Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Infection KW - Animal models KW - Cysticercosis KW - Inflammation KW - Therapy KW - Taenia KW - Taenia crassiceps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42232441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=A+Rat+Model+of+Intracerebral+Infection+with+Taenia+Crassiceps+for+the+Study+of+Inflammation+Associated+with+Anthelmintic+Therapy+in+Neurocysticercosis&rft.au=Mahanty%2C+Siddhartha%3BBerns%2C+Abby%3BScott%2C+Erick%3BLizak%2C+Martin%3BNash%2C+Theodore&rft.aulast=Mahanty&rft.aufirst=Siddhartha&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunological Priming in An. Gambiae: Can Mosquitoes 'Learn' from a Challenge with Plasmodium? T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42232114; 5591797 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Rodrigues, Janneth AU - Dixit, Rajnikant AU - Ortega, Corrie AU - Molina-Cruz, Alvaro AU - Mury, Carolina Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42232114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Immunological+Priming+in+An.+Gambiae%3A+Can+Mosquitoes+%27Learn%27+from+a+Challenge+with+Plasmodium%3F&rft.au=Rodrigues%2C+Janneth%3BDixit%2C+Rajnikant%3BOrtega%2C+Corrie%3BMolina-Cruz%2C+Alvaro%3BMury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparing the Quality of Informed Consent in the United States and Mali T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42229156; 5592573 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Ellis, Ruth AU - Sagara, Issaka AU - Durbin, Anna AU - Dicko, Alassane AU - Shaffer, Donna AU - Pierce, Mark AU - Miller, Louis AU - Assadou, Mahamadoun AU - Kone, Mamady AU - Kamate, Beh AU - Guindo, Ousmane AU - Fay, Michael AU - Diallo, Dapa AU - Doumbo, Ogobara AU - Emmanuel, Ezekiel AU - Millum, Joseph Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - USA KW - Mali KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42229156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Comparing+the+Quality+of+Informed+Consent+in+the+United+States+and+Mali&rft.au=Ellis%2C+Ruth%3BSagara%2C+Issaka%3BDurbin%2C+Anna%3BDicko%2C+Alassane%3BShaffer%2C+Donna%3BPierce%2C+Mark%3BMiller%2C+Louis%3BAssadou%2C+Mahamadoun%3BKone%2C+Mamady%3BKamate%2C+Beh%3BGuindo%2C+Ousmane%3BFay%2C+Michael%3BDiallo%2C+Dapa%3BDoumbo%2C+Ogobara%3BEmmanuel%2C+Ezekiel%3BMillum%2C+Joseph&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Plasmodium Falciparum Apical Membrane Antigen 1-Combination 1/Alhydrogel Vaccine on Growth-Inhibitory Activity of Antibodies in Children in Mali T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42229011; 5592533 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Tullo, Gregory AU - Aebig, Joan AU - Miller, Louis AU - Saul, Allan AU - Doumbo, Ogobara AU - Sagara, Issaka AU - Dicko, Alassane AU - Long, Carole AU - Ellis, Ruth Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Mali KW - Vaccines KW - Children KW - Membranes KW - Antibodies KW - Parasites KW - Antigens KW - Disease control KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42229011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Impact+of+Plasmodium+Falciparum+Apical+Membrane+Antigen+1-Combination+1%2FAlhydrogel+Vaccine+on+Growth-Inhibitory+Activity+of+Antibodies+in+Children+in+Mali&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BTullo%2C+Gregory%3BAebig%2C+Joan%3BMiller%2C+Louis%3BSaul%2C+Allan%3BDoumbo%2C+Ogobara%3BSagara%2C+Issaka%3BDicko%2C+Alassane%3BLong%2C+Carole%3BEllis%2C+Ruth&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anopheles Stephensi d7 L: A Salivary Gland Protein with Both Anti-Inflammatory and Antihemostatic Effect T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42228809; 5592300 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Alvarenga, Patricia AU - Calvo, Eric AU - Francischetti, Ivo AU - Sa-Nunes, Anderson AU - Ribeiro, Jose AU - Andersen, John Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Salivary gland KW - Inflammation KW - Aquatic insects KW - Glands KW - Anopheles stephensi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Anopheles+Stephensi+d7+L%3A+A+Salivary+Gland+Protein+with+Both+Anti-Inflammatory+and+Antihemostatic+Effect&rft.au=Alvarenga%2C+Patricia%3BCalvo%2C+Eric%3BFrancischetti%2C+Ivo%3BSa-Nunes%2C+Anderson%3BRibeiro%2C+Jose%3BAndersen%2C+John&rft.aulast=Alvarenga&rft.aufirst=Patricia&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Transcriptome of Loa Loa l3 Infective Larvae in Comparison to the l3 Transcriptomes of the Other Major Human Pathogenic Filariae T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42228540; 5591908 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Fink, Doran AU - Klion, Amy AU - Nutman, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Larvae KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Transcriptome+of+Loa+Loa+l3+Infective+Larvae+in+Comparison+to+the+l3+Transcriptomes+of+the+Other+Major+Human+Pathogenic+Filariae&rft.au=Fink%2C+Doran%3BKlion%2C+Amy%3BNutman%2C+Thomas&rft.aulast=Fink&rft.aufirst=Doran&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and Immunologic Cross Reactivity among Allergens and Homologous Helminth Antigens: Lessons Learned from Tropomyosin and Their Implication for the Hygiene Hypothesis T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42228208; 5592157 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Santiago, Helton AU - Bennuru, Sasisekhar AU - Nutman, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Hygiene KW - Helminths KW - Allergens KW - Tropomyosin KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Structural+and+Immunologic+Cross+Reactivity+among+Allergens+and+Homologous+Helminth+Antigens%3A+Lessons+Learned+from+Tropomyosin+and+Their+Implication+for+the+Hygiene+Hypothesis&rft.au=Santiago%2C+Helton%3BBennuru%2C+Sasisekhar%3BNutman%2C+Thomas&rft.aulast=Santiago&rft.aufirst=Helton&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ACMCIP ANNUAL BUSINESS MEETING T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42228163; 5591897 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Fairhurst, Rick Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=ACMCIP+ANNUAL+BUSINESS+MEETING&rft.au=Fairhurst%2C+Rick&rft.aulast=Fairhurst&rft.aufirst=Rick&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mal-Ed Network T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227978; 5591492 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Miller, Mark AU - Gottlieb, Michael Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Mal-Ed+Network&rft.au=Miller%2C+Mark%3BGottlieb%2C+Michael&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Attenuation of Tlr Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227936; 5592517 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Babu, Subash AU - Bhat, Sajid AU - Kumar, Pavan AU - Anuradha, R AU - Kumaran, Paul AU - Gopi, P AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Chemotherapy KW - Infection KW - Tuberculosis KW - Restoration KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Attenuation+of+Tlr+Expression+and+Function+in+Latent+Tuberculosis+by+Coexistent+Filarial+Infection+with+Restoration+Following+Antifilarial+Chemotherapy&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid%3BKumar%2C+Pavan%3BAnuradha%2C+R%3BKumaran%2C+Paul%3BGopi%2C+P%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purified Iggs Which Are Obtained from Malian Children and Which Do Not Bind to Apical Membrane Antigen 1(ama1) Interfere with the Biological Activity of ama1-Specific Iggs as Judged by the in Vitro Growth Inhibition Assay T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227814; 5591770 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Miura, Kazutoyo AU - Perera, Suwani AU - Brockley, Sarah AU - Zhou, Hong AU - Aebig, Joan AU - Moretz, Samuel AU - Miller, Louis AU - Sagara, Issaka AU - Dicko, Alassane AU - Ellis, Ruth AU - Long, Carole Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Children KW - Membranes KW - Immunoglobulin G KW - Antigens KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Purified+Iggs+Which+Are+Obtained+from+Malian+Children+and+Which+Do+Not+Bind+to+Apical+Membrane+Antigen+1%28ama1%29+Interfere+with+the+Biological+Activity+of+ama1-Specific+Iggs+as+Judged+by+the+in+Vitro+Growth+Inhibition+Assay&rft.au=Miura%2C+Kazutoyo%3BPerera%2C+Suwani%3BBrockley%2C+Sarah%3BZhou%2C+Hong%3BAebig%2C+Joan%3BMoretz%2C+Samuel%3BMiller%2C+Louis%3BSagara%2C+Issaka%3BDicko%2C+Alassane%3BEllis%2C+Ruth%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rotavirus: Global Burden of Diarrheal Disease and Early Impact of Vaccine Introduction T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227746; 5592491 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Glass, Roger Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Vaccines KW - Diarrhea KW - Disease control KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Rotavirus%3A+Global+Burden+of+Diarrheal+Disease+and+Early+Impact+of+Vaccine+Introduction&rft.au=Glass%2C+Roger&rft.aulast=Glass&rft.aufirst=Roger&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling Antibody Responses to P. Falciparum Infection by Protein Microarray-a Strategy for Identifying Novel Malaria Vaccine Targets T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227391; 5592373 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Crompton, Peter AU - Kayala, Matthew AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta AU - Molina, Douglas AU - Burk, Chad AU - Waisberg, Michael AU - Jasinskas, Algis AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Narum, David AU - Liang, Xiaowu AU - Doumboo, Ogobara AU - Miller, Louis AU - Doolan, Denise AU - Baldi, Pierre AU - Felgner, Philip AU - Pierce, Susan Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Infection KW - Vaccines KW - Malaria KW - Protein arrays KW - Antibodies KW - Disease control KW - Profiling KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Profiling+Antibody+Responses+to+P.+Falciparum+Infection+by+Protein+Microarray-a+Strategy+for+Identifying+Novel+Malaria+Vaccine+Targets&rft.au=Crompton%2C+Peter%3BKayala%2C+Matthew%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta%3BMolina%2C+Douglas%3BBurk%2C+Chad%3BWaisberg%2C+Michael%3BJasinskas%2C+Algis%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BNarum%2C+David%3BLiang%2C+Xiaowu%3BDoumboo%2C+Ogobara%3BMiller%2C+Louis%3BDoolan%2C+Denise%3BBaldi%2C+Pierre%3BFelgner%2C+Philip%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Novel Blood-Stage Vaccine Candidates against Plasmodium Falciparum by High-Throughput Immunoscreening T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227313; 5592299 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Takeo, Satoru AU - Sakamoto, Hirokazu AU - Kaneko, Takamasa AU - Tachibana, Mayumi AU - Miura, Kazutoyo AU - Varma, Sudhir AU - Sattabongkot, Jetsumon AU - Torii, Motomi AU - Tsuboi, Takafumi Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Vaccines KW - Parasites KW - Disease control KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Identification+of+Novel+Blood-Stage+Vaccine+Candidates+against+Plasmodium+Falciparum+by+High-Throughput+Immunoscreening&rft.au=Takeo%2C+Satoru%3BSakamoto%2C+Hirokazu%3BKaneko%2C+Takamasa%3BTachibana%2C+Mayumi%3BMiura%2C+Kazutoyo%3BVarma%2C+Sudhir%3BSattabongkot%2C+Jetsumon%3BTorii%2C+Motomi%3BTsuboi%2C+Takafumi&rft.aulast=Takeo&rft.aufirst=Satoru&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Longevity of Anopheles Gambiae s.l. Under Natural Conditions Using a Modified Mark Release Recapture Approach T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227203; 5591792 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Lehmann, Tovi AU - Alpha, Adamou AU - Diallo, Moussa AU - Yaro, Alpha AU - Kassogue, Yaya AU - Dao, Adama Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Longevity KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Longevity+of+Anopheles+Gambiae+s.l.+Under+Natural+Conditions+Using+a+Modified+Mark+Release+Recapture+Approach&rft.au=Lehmann%2C+Tovi%3BAlpha%2C+Adamou%3BDiallo%2C+Moussa%3BYaro%2C+Alpha%3BKassogue%2C+Yaya%3BDao%2C+Adama&rft.aulast=Lehmann&rft.aufirst=Tovi&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Populations of Circulating Myeloid and Plasmacytoid Dendritic Cells in Patent Filarial Infections T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42227123; 5592515 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Mahapatra, Lily AU - Dembele, Benoit AU - Metenou, Simon AU - Konate, Siaka AU - Dolo, Housseini AU - Coulibaly, Michel AU - Soumaoro, Lamine AU - Panka, Rungnapa AU - Chaussabel, Damien AU - Coulibaly, Siaka AU - Sanogo, Dramane AU - Doumbia, Salif AU - Diallo, Abdallah AU - Nutman, Thomas AU - Mahanty, Siddhartha AU - Semnani, Roshanak Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Infection KW - Patents KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Increased+Populations+of+Circulating+Myeloid+and+Plasmacytoid+Dendritic+Cells+in+Patent+Filarial+Infections&rft.au=Mahapatra%2C+Lily%3BDembele%2C+Benoit%3BMetenou%2C+Simon%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BCoulibaly%2C+Michel%3BSoumaoro%2C+Lamine%3BPanka%2C+Rungnapa%3BChaussabel%2C+Damien%3BCoulibaly%2C+Siaka%3BSanogo%2C+Dramane%3BDoumbia%2C+Salif%3BDiallo%2C+Abdallah%3BNutman%2C+Thomas%3BMahanty%2C+Siddhartha%3BSemnani%2C+Roshanak&rft.aulast=Mahapatra&rft.aufirst=Lily&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescence Multiplexing Imaging for Studying Protein Trafficking in Plasmodium Falciparum-Infected Human Erythrocytes Using Tetracysteine-Tagged Knob-Associated Proteins T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226991; 5592176 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Crivat, Georgeta AU - Sa, Juliana AU - Hwang, Jeeseong AU - Tokumasu, Fuyuki AU - Wellems, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Trafficking KW - Erythrocytes KW - Fluorescence KW - Protein transport KW - Imaging techniques KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Fluorescence+Multiplexing+Imaging+for+Studying+Protein+Trafficking+in+Plasmodium+Falciparum-Infected+Human+Erythrocytes+Using+Tetracysteine-Tagged+Knob-Associated+Proteins&rft.au=Crivat%2C+Georgeta%3BSa%2C+Juliana%3BHwang%2C+Jeeseong%3BTokumasu%2C+Fuyuki%3BWellems%2C+Thomas&rft.aulast=Crivat&rft.aufirst=Georgeta&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - P. Falciparum Cultivation in a Sodium-Free Medium T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226653; 5591211 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Addo, Rachel AU - Pillai, Ajay AU - Desai, Sanjay Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Cultivation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=P.+Falciparum+Cultivation+in+a+Sodium-Free+Medium&rft.au=Addo%2C+Rachel%3BPillai%2C+Ajay%3BDesai%2C+Sanjay&rft.aulast=Addo&rft.aufirst=Rachel&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research Ethics Training and the National Institutes of Health T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226291; 5592510 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Lie, Reidar Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Training KW - Ethics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Research+Ethics+Training+and+the+National+Institutes+of+Health&rft.au=Lie%2C+Reidar&rft.aulast=Lie&rft.aufirst=Reidar&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Human Dendritic Cells by Virulent Francisella Tularensis T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226203; 5592254 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Bosio, Catharine Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Dendritic cells KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Modulation+of+Human+Dendritic+Cells+by+Virulent+Francisella+Tularensis&rft.au=Bosio%2C+Catharine&rft.aulast=Bosio&rft.aufirst=Catharine&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Hemocytes from Aedes Aegypti and Aedes Albopictus T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226074; 5592097 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Alves, Luiz AU - Araujo, Helena AU - Baryner-Santos, Fabio AU - Pimenta, Paulo Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Hemocytes KW - Aquatic insects KW - Aedes albopictus KW - Aedes aegypti KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Characterization+of+Hemocytes+from+Aedes+Aegypti+and+Aedes+Albopictus&rft.au=Alves%2C+Luiz%3BAraujo%2C+Helena%3BBaryner-Santos%2C+Fabio%3BPimenta%2C+Paulo&rft.aulast=Alves&rft.aufirst=Luiz&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening and Genetic Mapping Targets of Differential Chemical-Response Phenotypes in Plasmodium Falciparum T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42226018; 5592222 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Yuan, Jing AU - Johnson, Ronald AU - Huang, Ruiling AU - Wichterman, Jennifer AU - Jiang, Hongying AU - Hayton, Karen AU - Fidock, David AU - Wellems, Thomas AU - Inglese, James AU - Austin, Christopher AU - Su, Xinzhuan Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Gene mapping KW - Parasites KW - Screening KW - Phenotypes KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Screening+and+Genetic+Mapping+Targets+of+Differential+Chemical-Response+Phenotypes+in+Plasmodium+Falciparum&rft.au=Yuan%2C+Jing%3BJohnson%2C+Ronald%3BHuang%2C+Ruiling%3BWichterman%2C+Jennifer%3BJiang%2C+Hongying%3BHayton%2C+Karen%3BFidock%2C+David%3BWellems%2C+Thomas%3BInglese%2C+James%3BAustin%2C+Christopher%3BSu%2C+Xinzhuan&rft.aulast=Yuan&rft.aufirst=Jing&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Nitric Oxide with Heme in P. Falciparum Food Vacuoles T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42225903; 5592179 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Ostera, Graciela AU - Lukat-Rodgers, Gudrun AU - Tokumasu, Fuyuki AU - Kumar, Sanjai AU - Rodgers, Kenton Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Nitric oxide KW - Heme KW - Food vacuoles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Association+of+Nitric+Oxide+with+Heme+in+P.+Falciparum+Food+Vacuoles&rft.au=Ostera%2C+Graciela%3BLukat-Rodgers%2C+Gudrun%3BTokumasu%2C+Fuyuki%3BKumar%2C+Sanjai%3BRodgers%2C+Kenton&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of the Biological Function of Antibodies Elicited Following Immunization of Malaria- NaiVe Subjects with a Plasmodium Falciparum Erythrocyte-Binding Antigen 175 (eba175) Vaccine T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42225873; 5592481 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Moretz, Samuel AU - Diouf, Ababacar AU - Zhou, Hong AU - Tullo, Gregory AU - El Sahli, Hanaa AU - Keitel, Wendy AU - Long, Carole Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Vaccines KW - Immunization KW - Antibodies KW - Parasites KW - Antigens KW - Disease control KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Analysis+of+the+Biological+Function+of+Antibodies+Elicited+Following+Immunization+of+Malaria-+NaiVe+Subjects+with+a+Plasmodium+Falciparum+Erythrocyte-Binding+Antigen+175+%28eba175%29+Vaccine&rft.au=Moretz%2C+Samuel%3BDiouf%2C+Ababacar%3BZhou%2C+Hong%3BTullo%2C+Gregory%3BEl+Sahli%2C+Hanaa%3BKeitel%2C+Wendy%3BLong%2C+Carole&rft.aulast=Moretz&rft.aufirst=Samuel&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of Passive Dispersal of Anopheles Gambiae in the Early Adult Phase T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42225330; 5592327 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Manoukis, Nicholas AU - Sogoba, Nafomon AU - Diallo, Moussa AU - Ribeiro, Jose Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Dispersal KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Evidence+of+Passive+Dispersal+of+Anopheles+Gambiae+in+the+Early+Adult+Phase&rft.au=Manoukis%2C+Nicholas%3BSogoba%2C+Nafomon%3BDiallo%2C+Moussa%3BRibeiro%2C+Jose&rft.aulast=Manoukis&rft.aufirst=Nicholas&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parasite Selection on the Human Host: The Hemoglobin Story T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42225261; 5592063 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Fairhurst, Rick Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Parasites KW - Hemoglobin KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Parasite+Selection+on+the+Human+Host%3A+The+Hemoglobin+Story&rft.au=Fairhurst%2C+Rick&rft.aulast=Fairhurst&rft.aufirst=Rick&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Epidemiology of Diarrheal Disease T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42225238; 5592276 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Miller, Mark Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Diarrhea KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Global+Epidemiology+of+Diarrheal+Disease&rft.au=Miller%2C+Mark&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Gene Linked to a New Antimalarial Drug Resistance Mechanism: Reduced Uptake by Infected Erythrocytes T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42224425; 5592547 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Lisk, Godfrey AU - Desai, Sanjay Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Erythrocytes KW - Drug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42224425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=A+Gene+Linked+to+a+New+Antimalarial+Drug+Resistance+Mechanism%3A+Reduced+Uptake+by+Infected+Erythrocytes&rft.au=Lisk%2C+Godfrey%3BDesai%2C+Sanjay&rft.aulast=Lisk&rft.aufirst=Godfrey&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Constraints on Parasitemia and Gametocytemia in Malaria: Insight from Numerical Studies T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42223979; 5591505 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - McQueen, Philip AU - McKenzie, Ellis Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Malaria KW - Parasitemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42223979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Immune+Constraints+on+Parasitemia+and+Gametocytemia+in+Malaria%3A+Insight+from+Numerical+Studies&rft.au=McQueen%2C+Philip%3BMcKenzie%2C+Ellis&rft.aulast=McQueen&rft.aufirst=Philip&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Alternatively-Activated Macrophages in Chronic Helminth Infection T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42223962; 5591968 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Wynn, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Infection KW - Helminths KW - Chronic infection KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42223962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Role+of+Alternatively-Activated+Macrophages+in+Chronic+Helminth+Infection&rft.au=Wynn%2C+Thomas&rft.aulast=Wynn&rft.aufirst=Thomas&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrastructural Study of Aedes Albopictus Skuse, 1895 (Diptera: Culicidae) Hemocytes T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42222622; 5592094 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Brayner-Santos, Fabio AU - Araujo, Helena AU - Alves, Luiz AU - Pimenta, Paulo Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Hemocytes KW - Aquatic insects KW - Aedes albopictus KW - Culicidae KW - Diptera KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42222622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Ultrastructural+Study+of+Aedes+Albopictus+Skuse%2C+1895+%28Diptera%3A+Culicidae%29+Hemocytes&rft.au=Brayner-Santos%2C+Fabio%3BAraujo%2C+Helena%3BAlves%2C+Luiz%3BPimenta%2C+Paulo&rft.aulast=Brayner-Santos&rft.aufirst=Fabio&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Joseph James Kinyoun: Founding Father of American Microbiology T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42222306; 5591174 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Morens, David Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Microbiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42222306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Joseph+James+Kinyoun%3A+Founding+Father+of+American+Microbiology&rft.au=Morens%2C+David&rft.aulast=Morens&rft.aufirst=David&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Can the Mosquito Immune System Learn from Experience? T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42221429; 5591941 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Barillas-Mury, Carolina Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Immune system KW - Aquatic insects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42221429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Can+the+Mosquito+Immune+System+Learn+from+Experience%3F&rft.au=Barillas-Mury%2C+Carolina&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Balancing the Tensions between Research and Human Safety in Vector Biology Research T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42219879; 5591536 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Costero, Adriana Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Balancing+the+Tensions+between+Research+and+Human+Safety+in+Vector+Biology+Research&rft.au=Costero%2C+Adriana&rft.aulast=Costero&rft.aufirst=Adriana&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update from National Institutes of Health T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42219833; 5591963 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Su, Xinzhuan Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Update+from+National+Institutes+of+Health&rft.au=Su%2C+Xinzhuan&rft.aulast=Su&rft.aufirst=Xinzhuan&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Small Molecule Tools and Screening Technologies for Neglected Tropical Diseases T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42219775; 5591951 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Austin, Christopher Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Technology KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Use+of+Small+Molecule+Tools+and+Screening+Technologies+for+Neglected+Tropical+Diseases&rft.au=Austin%2C+Christopher&rft.aulast=Austin&rft.aufirst=Christopher&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Funding Opportunities for International Investigators T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42219361; 5591103 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Sina, Barbara Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Funding+Opportunities+for+International+Investigators&rft.au=Sina%2C+Barbara&rft.aulast=Sina&rft.aufirst=Barbara&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Cohort-Based Study of Leishmania Major Infection and Cutaneous Leishmaniasis in Mali T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42219303; 5591688 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Doumbia, Seydou AU - Faye, Ousmane AU - Oliveira, Fabiano AU - Anderson, Jennifer AU - Traore, Pierre AU - Diarra, Souleymane AU - Tall, Koureissi AU - Sissoko, Ibrahim AU - Diallo, Daouda AU - Samake, Sibiry AU - Coulibaly, Cheick AU - Traore, Bourama AU - Teixeira, Clarissa AU - Gomez, Regis AU - Soucko, Constance AU - Lawyer, Phil AU - Keita, Somita AU - Fairhurst, Rick AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Mali KW - Infection KW - Cutaneous leishmaniasis KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=A+Cohort-Based+Study+of+Leishmania+Major+Infection+and+Cutaneous+Leishmaniasis+in+Mali&rft.au=Doumbia%2C+Seydou%3BFaye%2C+Ousmane%3BOliveira%2C+Fabiano%3BAnderson%2C+Jennifer%3BTraore%2C+Pierre%3BDiarra%2C+Souleymane%3BTall%2C+Koureissi%3BSissoko%2C+Ibrahim%3BDiallo%2C+Daouda%3BSamake%2C+Sibiry%3BCoulibaly%2C+Cheick%3BTraore%2C+Bourama%3BTeixeira%2C+Clarissa%3BGomez%2C+Regis%3BSoucko%2C+Constance%3BLawyer%2C+Phil%3BKeita%2C+Somita%3BFairhurst%2C+Rick%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Doumbia&rft.aufirst=Seydou&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Sponsor Perspective: Safety and Data Integrity in Clinical Research T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42218378; 5591534 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Nesin, Mirjana Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Clinical trials KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Sponsor+Perspective%3A+Safety+and+Data+Integrity+in+Clinical+Research&rft.au=Nesin%2C+Mirjana&rft.aulast=Nesin&rft.aufirst=Mirjana&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Peer Review Process at the National Institutes of Health T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42218155; 5591100 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Politis, Alexander Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Peer+Review+Process+at+the+National+Institutes+of+Health&rft.au=Politis%2C+Alexander&rft.aulast=Politis&rft.aufirst=Alexander&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institutes of Health Research Opportunities and Priorities for Hivassociated Co-Infections T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42216764; 5591048 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Eisinger, Robert Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=National+Institutes+of+Health+Research+Opportunities+and+Priorities+for+Hivassociated+Co-Infections&rft.au=Eisinger%2C+Robert&rft.aulast=Eisinger&rft.aufirst=Robert&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decoding the Invasion and Molting Processes of Brugia Malayi l3 Larvae T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42216353; 5590921 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Bennuru, Sasisekhar AU - Nutman, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Larvae KW - Invasions KW - Molting KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Decoding+the+Invasion+and+Molting+Processes+of+Brugia+Malayi+l3+Larvae&rft.au=Bennuru%2C+Sasisekhar%3BNutman%2C+Thomas&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public and Scientific Accountability: How Will You Measure up in the Future? T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42215953; 5591046 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - McGowan, John Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Accountability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Public+and+Scientific+Accountability%3A+How+Will+You+Measure+up+in+the+Future%3F&rft.au=McGowan%2C+John&rft.aulast=McGowan&rft.aufirst=John&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tick Borne Relapsing Fever in Mali T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42215913; 5591024 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Anderson, Jennifer AU - Lopez, Job AU - Sogoba, Nafomon AU - Schrumpf, Merry AU - Raffel, Sandra AU - Schwan, Tom Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Mali KW - Relapsing fever KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Tick+Borne+Relapsing+Fever+in+Mali&rft.au=Anderson%2C+Jennifer%3BLopez%2C+Job%3BSogoba%2C+Nafomon%3BSchrumpf%2C+Merry%3BRaffel%2C+Sandra%3BSchwan%2C+Tom&rft.aulast=Anderson&rft.aufirst=Jennifer&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Grants Management: What You Need to Know after Award T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42215360; 5591101 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Kirker, Mary Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Awards KW - Grants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Grants+Management%3A+What+You+Need+to+Know+after+Award&rft.au=Kirker%2C+Mary&rft.aulast=Kirker&rft.aufirst=Mary&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Does Plasmodium Falciparum Evade of the Mosquito Immune System T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42214915; 5591301 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Molina-Cruz, Alvaro AU - Ortega, Corrie AU - Winikor, Jared AU - Rodrigues, Janneth AU - Barillas-Mury, Carolina Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Immune system KW - Parasites KW - Aquatic insects KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=How+Does+Plasmodium+Falciparum+Evade+of+the+Mosquito+Immune+System&rft.au=Molina-Cruz%2C+Alvaro%3BOrtega%2C+Corrie%3BWinikor%2C+Jared%3BRodrigues%2C+Janneth%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Evaluation of Live Attenuated den3 Vaccine Candidates T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42214622; 5591594 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Whitehead, Stephen AU - Schmidt, Alexander AU - McArthur, Julie AU - Marron, Jennifer AU - Elwood, Daniel AU - Thumar, Bhavin AU - Wanionek, Kimberli AU - Pierro, Dennis AU - Blaney, Joseph AU - Murphy, Brian AU - Durbin, Anna Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Clinical+Evaluation+of+Live+Attenuated+den3+Vaccine+Candidates&rft.au=Whitehead%2C+Stephen%3BSchmidt%2C+Alexander%3BMcArthur%2C+Julie%3BMarron%2C+Jennifer%3BElwood%2C+Daniel%3BThumar%2C+Bhavin%3BWanionek%2C+Kimberli%3BPierro%2C+Dennis%3BBlaney%2C+Joseph%3BMurphy%2C+Brian%3BDurbin%2C+Anna&rft.aulast=Whitehead&rft.aufirst=Stephen&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Training Funding Mechanisms T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42213371; 5591102 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Hernandez, Milton Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Training KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Training+Funding+Mechanisms&rft.au=Hernandez%2C+Milton&rft.aulast=Hernandez&rft.aufirst=Milton&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patent Filarial Infection Modulates the Quality of T Cell Responses to Malarial Antigens in Malaria/Filarial Co-Endemic Village of Mali T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42213307; 5590920 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Metenou, Simon AU - Dembele, Benoit AU - Konate, Siaka AU - Dolo, Housseini AU - Soumaoro, Lamine AU - Diallo, Abdallah AU - Coulibaly, Michel AU - Coulibaly, Siaka AU - Sanogo, Dramane AU - Coulibaly, Yaya AU - Traore, Sekou AU - Mahanty, Siddhartha AU - Klion, Amy AU - Nutman, Thomas Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Mali KW - Villages KW - Infection KW - Patents KW - Malaria KW - Lymphocytes T KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Patent+Filarial+Infection+Modulates+the+Quality+of+T+Cell+Responses+to+Malarial+Antigens+in+Malaria%2FFilarial+Co-Endemic+Village+of+Mali&rft.au=Metenou%2C+Simon%3BDembele%2C+Benoit%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BSoumaoro%2C+Lamine%3BDiallo%2C+Abdallah%3BCoulibaly%2C+Michel%3BCoulibaly%2C+Siaka%3BSanogo%2C+Dramane%3BCoulibaly%2C+Yaya%3BTraore%2C+Sekou%3BMahanty%2C+Siddhartha%3BKlion%2C+Amy%3BNutman%2C+Thomas&rft.aulast=Metenou&rft.aufirst=Simon&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reflections on National Institute of Allergy and Infectious Diseases and the History of Tropical Medicine T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42213203; 5591047 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Morens, David Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Historical account KW - Hypersensitivity KW - Infectious diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Reflections+on+National+Institute+of+Allergy+and+Infectious+Diseases+and+the+History+of+Tropical+Medicine&rft.au=Morens%2C+David&rft.aulast=Morens&rft.aufirst=David&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Research Funding Opportunities T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42210847; 5591049 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Haggerty, Patricia Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42210847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Identifying+Research+Funding+Opportunities&rft.au=Haggerty%2C+Patricia&rft.aulast=Haggerty&rft.aufirst=Patricia&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment. AN - 734148728; 19892741 AB - Treatment of mice bearing orthotopic, metastatic tumors with anti-CD40 antibody resulted in only partial, transient anti-tumor effects whereas combined treatment with IL-2/anti-CD40, induced tumor regression. The mechanisms for these divergent anti-tumor responses were examined by profiling tumor-infiltrating leukocyte subsets and chemokine expression within the tumor microenvironment after immunotherapy. IL-2/anti-CD40, but not anti-CD40 alone, induced significant infiltration of established tumors by NK and CD8(+) T cells. To further define the role of chemokines in leukocyte recruitment into tumors, we evaluated anti-tumor responses in mice lacking the chemokine receptor, CCR2. The anti-tumor effects and leukocyte recruitment mediated by anti-CD40 alone, were completely abolished in CCR2(-/-) mice. In contrast, IL-2/anti-CD40-mediated leukocyte recruitment and reductions in primary tumors and metastases were maintained in CCR2(-/-) mice. Treatment of mice with IL-2/anti-CD40, but not anti-CD40 alone, also caused an IFN-gamma-dependent increase in the expression of multiple Th1 chemokines within the tumor microenvironment. Interestingly, although IL-2/anti-CD40 treatment increased Tregs in the spleen, it also caused a coincident IFN-gamma-dependent reduction in CD4(+)/FoxP3(+) Tregs, myeloid-derived suppressor cells and Th2 chemokine expression specifically within the tumor microenvironment that was not observed after treatment with anti-CD40 alone. Similar effects were observed using IL-15 in combination with anti-CD40. Taken together, our data demonstrate that IL-2/anti-CD40, but not anti-CD40 alone, can preferentially reduce the overall immunosuppressive milieu within the tumor microenvironment. These results suggest that the use of anti-CD40 in combination with IL-2 or IL-15 may hold substantially more promise for clinical cancer treatment than anti-CD40 alone. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Weiss, Jonathan M AU - Back, Timothy C AU - Scarzello, Anthony J AU - Subleski, Jeff J AU - Hall, Veronica L AU - Stauffer, Jimmy K AU - Chen, Xin AU - Micic, Dejan AU - Alderson, Kory AU - Murphy, William J AU - Wiltrout, Robert H AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, NCI Frederick, Frederick, MD 21702, USA. Y1 - 2009/11/17/ PY - 2009 DA - 2009 Nov 17 SP - 19455 EP - 19460 VL - 106 IS - 46 KW - Antibodies KW - 0 KW - Antigens, CD40 KW - Ccl9 protein, mouse KW - Ccr2 protein, mouse KW - Chemokine CCL5 KW - Chemokine CXCL9 KW - Chemokines KW - Chemokines, CC KW - Cxcl9 protein, mouse KW - IP10-Mig receptor KW - Interleukin-2 KW - Macrophage Inflammatory Proteins KW - Receptors, CCR2 KW - Receptors, Cytokine KW - Arginase KW - EC 3.5.3.1 KW - Index Medicus KW - Chemokine CCL5 -- biosynthesis KW - Receptors, CCR2 -- genetics KW - Receptors, CCR2 -- biosynthesis KW - Animals KW - Lymphocytes, Tumor-Infiltrating -- immunology KW - Receptors, Cytokine -- biosynthesis KW - CD4-Positive T-Lymphocytes -- immunology KW - Chemokines -- biosynthesis KW - Mice KW - Mice, Inbred BALB C KW - Chemokine CXCL9 -- biosynthesis KW - CD8-Positive T-Lymphocytes -- immunology KW - Arginase -- biosynthesis KW - Drug Synergism KW - Chemokines, CC -- biosynthesis KW - Macrophage Inflammatory Proteins -- biosynthesis KW - Antibodies -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Antigens, CD40 -- agonists KW - Neoplasms -- therapy KW - Immunosuppression -- methods KW - Antigens, CD40 -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734148728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Successful+immunotherapy+with+IL-2%2Fanti-CD40+induces+the+chemokine-mediated+mitigation+of+an+immunosuppressive+tumor+microenvironment.&rft.au=Weiss%2C+Jonathan+M%3BBack%2C+Timothy+C%3BScarzello%2C+Anthony+J%3BSubleski%2C+Jeff+J%3BHall%2C+Veronica+L%3BStauffer%2C+Jimmy+K%3BChen%2C+Xin%3BMicic%2C+Dejan%3BAlderson%2C+Kory%3BMurphy%2C+William+J%3BWiltrout%2C+Robert+H&rft.aulast=Weiss&rft.aufirst=Jonathan&rft.date=2009-11-17&rft.volume=106&rft.issue=46&rft.spage=19455&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0909474106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2003 Aug 15;21(16):3127-32 [12915604] Proc Natl Acad Sci U S A. 2009 May 5;106(18):7513-8 [19383782] Cancer Res. 2003 Nov 1;63(21):7451-61 [14612545] Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69 [15027487] Nat Med. 2004 Sep;10(9):942-9 [15322536] Res Commun Chem Pathol Pharmacol. 1981 Nov;34(2):345-9 [7335958] J Exp Med. 1990 Jun 1;171(6):2177-82 [2161898] Eur J Immunol. 1995 Apr;25(4):1101-4 [7537672] J Leukoc Biol. 1995 Jun;57(6):929-35 [7790776] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12053-8 [9342361] J Clin Invest. 1998 Sep 15;102(6):1112-24 [9739045] Blood. 1998 Oct 15;92(8):2668-71 [9763548] Int J Cancer. 2000 Jan 15;85(2):182-8 [10629075] Eur J Immunol. 2000 Apr;30(4):1030-9 [10760790] J Immunol. 2003 Mar 1;170(5):2727-33 [12594303] Trends Immunol. 2004 Dec;25(12):677-86 [15530839] J Immunol. 2005 May 15;174(10):6013-22 [15879094] Cancer Immunol Immunother. 2005 Sep;54(9):858-66 [15887015] Int J Cancer. 2005 Oct 10;116(6):949-56 [15856455] Melanoma Res. 2005 Oct;15(5):417-25 [16179869] Cell Immunol. 2005 Jun;235(2):145-52 [16213477] J Immunol. 2006 Jun 1;176(11):6543-52 [16709811] Cancer Sci. 2006 Aug;97(8):780-6 [16863511] Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):721s-726s [17255300] J Clin Oncol. 2007 Mar 1;25(7):876-83 [17327609] J Immunother. 2007 May-Jun;30(4):417-24 [17457216] J Clin Invest. 2007 May;117(5):1155-66 [17476345] Cancer Lett. 2007 Jul 8;252(1):86-92 [17257744] Cancer Cell. 2008 Jan;13(1):23-35 [18167337] J Immunol. 2008 Mar 1;180(5):2981-8 [18292520] Clin Cancer Res. 2009 Feb 1;15(3):1052-8 [19188179] J Immunol. 2009 Mar 1;182(5):2753-65 [19234170] Cancer Res. 2009 Mar 1;69(5):2000-9 [19244125] Clin Cancer Res. 2009 Mar 15;15(6):2148-57 [19276286] Cytokine. 2003 Aug 21-Sep 7;23(4-5):126-32 [12967648] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0909474106 ER - TY - JOUR T1 - Static and dynamic characteristics of cerebral blood flow during the resting state AN - 746154597; 12978659 AB - In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions. JF - NeuroImage AU - Zou, Qihong AU - Wu, Changwei W AU - Stein, Elliot A AU - Zang, Yufeng AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200, Baltimore, MD 21224, USA, zangyf@bnu.edu.cnyihongyang@intra.nida.nih.gov Y1 - 2009/11/15/ PY - 2009 DA - 2009 Nov 15 SP - 515 EP - 524 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 48 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - CBF KW - Static KW - Dynamic KW - Functional connectivity KW - ALFF KW - ReHo KW - Resting state KW - Neuroimaging KW - Perfusion KW - Neural networks KW - superior temporal gyrus KW - Brain KW - Positron emission tomography KW - Cortex (temporal) KW - Cerebral blood flow KW - Cortex (prefrontal) KW - Thalamus KW - Cortex (cingulate) KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746154597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Static+and+dynamic+characteristics+of+cerebral+blood+flow+during+the+resting+state&rft.au=Zou%2C+Qihong%3BWu%2C+Changwei+W%3BStein%2C+Elliot+A%3BZang%2C+Yufeng%3BYang%2C+Yihong&rft.aulast=Zou&rft.aufirst=Qihong&rft.date=2009-11-15&rft.volume=48&rft.issue=3&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Perfusion; superior temporal gyrus; Neural networks; Positron emission tomography; Brain; Cortex (temporal); Cortex (cingulate); Thalamus; Cortex (prefrontal); Cerebral blood flow DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.006 ER - TY - CPAPER T1 - Sexually Abused Institutionalized Adolescents: Indicators for Multidimensional Interventions T2 - 12th Australasian Conference on Child Abuse and Neglect (ACCAN 2009) AN - 42015971; 5482746 JF - 12th Australasian Conference on Child Abuse and Neglect (ACCAN 2009) AU - Jangam, Kavita Y1 - 2009/11/15/ PY - 2009 DA - 2009 Nov 15 KW - Adolescents KW - Intervention KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42015971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Australasian+Conference+on+Child+Abuse+and+Neglect+%28ACCAN+2009%29&rft.atitle=Sexually+Abused+Institutionalized+Adolescents%3A+Indicators+for+Multidimensional+Interventions&rft.au=Jangam%2C+Kavita&rft.aulast=Jangam&rft.aufirst=Kavita&rft.date=2009-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Australasian+Conference+on+Child+Abuse+and+Neglect+%28ACCAN+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.apccan2009.org.au/pdf/APCCAN%202009%20Final%20Program%2023. 10.09.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aortic Atherosclerosis and Left Ventricular Structure in the Community T2 - 2009 American Heart Association Scientific Sessions AN - 42249410; 5599877 JF - 2009 American Heart Association Scientific Sessions AU - Velagaleti, Raghava AU - O'Donnell, Christopher Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Ventricle KW - Arteriosclerosis KW - Heart KW - Aorta KW - Community composition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42249410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Aortic+Atherosclerosis+and+Left+Ventricular+Structure+in+the+Community&rft.au=Velagaleti%2C+Raghava%3BO%27Donnell%2C+Christopher&rft.aulast=Velagaleti&rft.aufirst=Raghava&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Left Ventricular Hypertrophy Patterns and the Incidence of Heart Failure: The Framingham Heart Study T2 - 2009 American Heart Association Scientific Sessions AN - 42245324; 5600054 JF - 2009 American Heart Association Scientific Sessions AU - Velagaleti, Raghava AU - Vasan, Ramachandran Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Heart diseases KW - Ventricle KW - Hypertrophy KW - Circulatory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42245324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Left+Ventricular+Hypertrophy+Patterns+and+the+Incidence+of+Heart+Failure%3A+The+Framingham+Heart+Study&rft.au=Velagaleti%2C+Raghava%3BVasan%2C+Ramachandran&rft.aulast=Velagaleti&rft.aufirst=Raghava&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical and Doppler Echocardiographic Correlates of VE/VCO2 Slope in Systolic Heart Failure: The HF-ACTION Trial T2 - 2009 American Heart Association Scientific Sessions AN - 42244022; 5599781 JF - 2009 American Heart Association Scientific Sessions AU - Fleg, Jerome AU - Gardin, Julius Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Heart diseases KW - Doppler effect KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42244022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Clinical+and+Doppler+Echocardiographic+Correlates+of+VE%2FVCO2+Slope+in+Systolic+Heart+Failure%3A+The+HF-ACTION+Trial&rft.au=Fleg%2C+Jerome%3BGardin%2C+Julius&rft.aulast=Fleg&rft.aufirst=Jerome&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension: Results From a Genome-wide Association Study in 29,136 Individuals T2 - 2009 American Heart Association Scientific Sessions AN - 42241559; 5601507 JF - 2009 American Heart Association Scientific Sessions AU - Johnson, Andrew Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Hypertension KW - Blood pressure KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42241559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Association+of+Hypertension+Drug+Target+Genes+With+Blood+Pressure+and+Hypertension%3A+Results+From+a+Genome-wide+Association+Study+in+29%2C136+Individuals&rft.au=Johnson%2C+Andrew&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantifi cation of Absolute Myocardial Blood Flow With Contrast Enhanced MRI Approaching a Pixel Resolution: Validation vs. Microspheres T2 - 2009 American Heart Association Scientific Sessions AN - 42240329; 5599461 JF - 2009 American Heart Association Scientific Sessions AU - Hsu, Li-Yueh AU - Arai, Andrew Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Cations KW - Microspheres KW - Magnetic resonance imaging KW - Blood circulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42240329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Quantifi+cation+of+Absolute+Myocardial+Blood+Flow+With+Contrast+Enhanced+MRI+Approaching+a+Pixel+Resolution%3A+Validation+vs.+Microspheres&rft.au=Hsu%2C+Li-Yueh%3BArai%2C+Andrew&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Notifi able Genetic Variants on Commercially Available SNP Arrays: Implications for Research Participants in Genome-wide Association Studies for Cardiovascular Disease T2 - 2009 American Heart Association Scientific Sessions AN - 42237322; 5600974 JF - 2009 American Heart Association Scientific Sessions AU - Johnson, Andrew AU - O'Donnell, Christopher Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Cardiovascular diseases KW - Single-nucleotide polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Notifi+able+Genetic+Variants+on+Commercially+Available+SNP+Arrays%3A+Implications+for+Research+Participants+in+Genome-wide+Association+Studies+for+Cardiovascular+Disease&rft.au=Johnson%2C+Andrew%3BO%27Donnell%2C+Christopher&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Platelet Aggregation Genes Are Identified by Genome-wide Association Metaanalyses T2 - 2009 American Heart Association Scientific Sessions AN - 42235955; 5601504 JF - 2009 American Heart Association Scientific Sessions AU - Johnson, Andrew AU - Becker, Lewis Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Platelet aggregation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42235955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Multiple+Platelet+Aggregation+Genes+Are+Identified+by+Genome-wide+Association+Metaanalyses&rft.au=Johnson%2C+Andrew%3BBecker%2C+Lewis&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pericardial Fat is Associated With Prevalent AF - The Framingham Heart Study T2 - 2009 American Heart Association Scientific Sessions AN - 42234724; 5600612 JF - 2009 American Heart Association Scientific Sessions AU - Thanassoulis, George AU - Benjamin, Emelia Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42234724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=Pericardial+Fat+is+Associated+With+Prevalent+AF+-+The+Framingham+Heart+Study&rft.au=Thanassoulis%2C+George%3BBenjamin%2C+Emelia&rft.aulast=Thanassoulis&rft.aufirst=George&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Pathway for the Regulation of Hepatic Cholesterol Synthesis by microRNA's T2 - 2009 American Heart Association Scientific Sessions AN - 42231077; 5600387 JF - 2009 American Heart Association Scientific Sessions AU - Vickers, Kasey AU - Remaley, Alan Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Cholesterol KW - MiRNA KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42231077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Heart+Association+Scientific+Sessions&rft.atitle=A+Novel+Pathway+for+the+Regulation+of+Hepatic+Cholesterol+Synthesis+by+microRNA%27s&rft.au=Vickers%2C+Kasey%3BRemaley%2C+Alan&rft.aulast=Vickers&rft.aufirst=Kasey&rft.date=2009-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Heart+Association+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed. AN - 734129782; 19737938 AB - KillerRed is the only known fluorescent protein that demonstrates notable phototoxicity, exceeding that of the other green and red fluorescent proteins by at least 1,000-fold. KillerRed could serve as an instrument to inactivate target proteins or to kill cell populations in photodynamic therapy. However, the nature of KillerRed phototoxicity has remained unclear, impeding the development of more phototoxic variants. Here we present the results of a high resolution crystallographic study of KillerRed in the active fluorescent and in the photobleached non-fluorescent states. A unique and striking feature of the structure is a water-filled channel reaching the chromophore area from the end cap of the beta-barrel that is probably one of the key structural features responsible for phototoxicity. A study of the structure-function relationship of KillerRed, supported by structure-based, site-directed mutagenesis, has also revealed the key residues most likely responsible for the phototoxic effect. In particular, Glu(68) and Ser(119), located adjacent to the chromophore, have been assigned as the primary trigger of the reaction chain. JF - The Journal of biological chemistry AU - Pletnev, Sergei AU - Gurskaya, Nadya G AU - Pletneva, Nadya V AU - Lukyanov, Konstantin A AU - Chudakov, Dmitri M AU - Martynov, Vladimir I AU - Popov, Vladimir O AU - Kovalchuk, Mikhail V AU - Wlodawer, Alexander AU - Dauter, Zbigniew AU - Pletnev, Vladimir AD - Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute/SAIC-Frederick Inc., Frederick, Maryland 21702, USA. Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 SP - 32028 EP - 32039 VL - 284 IS - 46 KW - Photosensitizing Agents KW - 0 KW - killer red protein, Anthomedusae KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Humans KW - Mutation -- genetics KW - Dermatitis, Phototoxic KW - Crystallography, X-Ray KW - Protein Conformation KW - Photosensitizing Agents -- toxicity KW - Photosensitizing Agents -- chemistry KW - Green Fluorescent Proteins -- toxicity KW - Green Fluorescent Proteins -- chemistry KW - Light KW - Green Fluorescent Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734129782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structural+basis+for+phototoxicity+of+the+genetically+encoded+photosensitizer+KillerRed.&rft.au=Pletnev%2C+Sergei%3BGurskaya%2C+Nadya+G%3BPletneva%2C+Nadya+V%3BLukyanov%2C+Konstantin+A%3BChudakov%2C+Dmitri+M%3BMartynov%2C+Vladimir+I%3BPopov%2C+Vladimir+O%3BKovalchuk%2C+Mikhail+V%3BWlodawer%2C+Alexander%3BDauter%2C+Zbigniew%3BPletnev%2C+Vladimir&rft.aulast=Pletnev&rft.aufirst=Sergei&rft.date=2009-11-13&rft.volume=284&rft.issue=46&rft.spage=32028&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.054973 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-24 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3GB3; PDB; 3GL4 N1 - SuppNotes - Cited By: Biochemistry. 2000 Aug 8;39(31):9164-73 [10924110] FEBS Lett. 2009 Sep 3;583(17):2839-42 [19646983] Nat Struct Biol. 2000 Dec;7(12):1133-8 [11101896] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):462-7 [11209050] Bioelectrochemistry. 2001 Mar;53(2):233-41 [11339312] FEBS Lett. 2002 Jan 30;511(1-3):11-4 [11821040] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4256-61 [11929996] BMC Biochem. 2001;2:6 [11459517] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12111-6 [14523232] J Biol Chem. 2003 Nov 7;278(45):44626-31 [12909624] Nat Biotechnol. 2004 Mar;22(3):289-96 [14990950] Biofizika. 2004 Mar-Apr;49(2):305-21 [15129630] Gene. 1989 Apr 15;77(1):51-9 [2744487] J Mol Graph. 1993 Jun;11(2):134-8, 127-8 [8347566] Int J Radiat Biol. 1995 Jan;67(1):85-91 [7852821] Protein Eng. 1995 Feb;8(2):127-34 [7630882] Biochem Biophys Res Commun. 1998 Mar 6;244(1):263-7 [9514912] Nat Biotechnol. 1996 Oct;14(10):1246-51 [9631087] Biochemistry. 1998 Dec 8;37(49):17199-208 [9860833] Nat Struct Biol. 1999 May;6(5):458-63 [10331874] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Nat Biotechnol. 2004 Dec;22(12):1567-72 [15558047] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3558-63 [15738426] Biophys J. 2005 Apr;88(4):2452-61 [15681647] J Mol Biol. 2005 May 27;349(1):223-37 [15876379] J Biol Chem. 2005 Jul 15;280(28):26248-55 [15888441] Biochemistry. 2005 Jul 26;44(29):9833-40 [16026155] J Biomed Opt. 2005 Jul-Aug;10(4):41202 [16178626] Nat Rev Cancer. 2005 Oct;5(10):796-806 [16195751] Science. 2005 Nov 25;310(5752):1311-3 [16311331] Trends Biotechnol. 2005 Dec;23(12):605-13 [16269193] Curr Top Dev Biol. 2005;70:121-44 [16338340] Nat Biotechnol. 2006 Jan;24(1):95-9 [16369538] J Am Chem Soc. 2006 Apr 12;128(14):4685-93 [16594705] J Pediatr Surg. 2006 Aug;41(8):1369-76 [16863839] EMBO Rep. 2006 Oct;7(10):1006-12 [16936637] Curr Opin Struct Biol. 2006 Dec;16(6):714-21 [17064887] Nat Protoc. 2006;1(2):947-53 [17406328] Nat Methods. 2007 Jul;4(7):555-7 [17572680] Nat Methods. 2007 Sep;4(9):741-6 [17721542] Biochim Biophys Acta. 2007 Sep;1776(1):86-107 [17693025] Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1082-93 [17881826] Bioorg Khim. 2007 Jul-Aug;33(4):421-30 [17886433] J Cell Sci. 2007 Dec 15;120(Pt 24):4247-60 [18057027] Annu Rev Biomed Eng. 2008;10:1-38 [18647110] Biochemistry. 2008 Sep 23;47(38):10111-22 [18759496] J Biol Chem. 2008 Oct 24;283(43):28980-7 [18682399] Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9221-5 [19458251] J Biol Chem. 2000 Aug 25;275(34):25879-82 [10852900] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.054973 ER - TY - JOUR T1 - Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum. AN - 733988747; 19915665 AB - Methamphetamine (METH) is an illicit drug which is neurotoxic to the mammalian brain. Numerous studies have revealed significant decreases in dopamine and serotonin levels in the brains of animals exposed to moderate-to-large METH doses given within short intervals of time. In contrast, repeated injections of small nontoxic doses of the drug followed by a challenge with toxic METH doses afford significant protection against monoamine depletion. The present study was undertaken to test the possibility that repeated injections of the drug might be accompanied by transcriptional changes involved in rendering the nigrostriatal dopaminergic system refractory to METH toxicity. Our results confirm that METH preconditioning can provide significant protection against METH-induced striatal dopamine depletion. In addition, the presence and absence of METH preconditioning were associated with substantial differences in the identity of the genes whose expression was affected by a toxic METH challenge. Quantitative PCR confirmed METH-induced changes in genes of interest and identified additional genes that were differentially impacted by the toxic METH challenge in the presence of METH preconditioning. These genes include small heat shock 27 kD 27 protein 2 (HspB2), thyrotropin-releasing hormone (TRH), brain derived neurotrophic factor (BDNF), c-fos, and some encoding antioxidant proteins including CuZn superoxide dismutase (CuZnSOD), glutathione peroxidase (GPx)-1, and heme oxygenase-1 (Hmox-1). These observations are consistent, in part, with the transcriptional alterations reported in models of lethal ischemic injuries which are preceded by ischemic or pharmacological preconditioning. Our findings suggest that multiple molecular pathways might work in tandem to protect the nigrostriatal dopaminergic pathway against the deleterious effects of the toxic psychostimulant. Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse. JF - PloS one AU - Cadet, Jean Lud AU - McCoy, Michael T AU - Cai, Ning Sheng AU - Krasnova, Irina N AU - Ladenheim, Bruce AU - Beauvais, Genevieve AU - Wilson, Natascha AU - Wood, William AU - Becker, Kevin G AU - Hodges, Amber B AD - Molecular Neuropsychiatry Research Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore, MD, USA. jcadet@intra.nida.nih.gov Y1 - 2009/11/12/ PY - 2009 DA - 2009 Nov 12 SP - 1 VL - 4 IS - 11 KW - Central Nervous System Stimulants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Sprague-Dawley KW - Central Nervous System Stimulants -- pharmacology KW - Oligonucleotide Array Sequence Analysis KW - Chromatography, High Pressure Liquid -- methods KW - Dopamine -- metabolism KW - Gene Expression Regulation KW - Serotonin -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Mesencephalon -- drug effects KW - Methamphetamine -- pharmacology KW - Brain Injuries -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733988747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Methamphetamine+preconditioning+alters+midbrain+transcriptional+responses+to+methamphetamine-induced+injury+in+the+rat+striatum.&rft.au=Cadet%2C+Jean+Lud%3BMcCoy%2C+Michael+T%3BCai%2C+Ning+Sheng%3BKrasnova%2C+Irina+N%3BLadenheim%2C+Bruce%3BBeauvais%2C+Genevieve%3BWilson%2C+Natascha%3BWood%2C+William%3BBecker%2C+Kevin+G%3BHodges%2C+Amber+B&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2009-11-12&rft.volume=4&rft.issue=11&rft.spage=e7812&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007812 LA - English DB - ProQuest Environmental 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May 21;260(5111):1130-2 [8493557] J Cell Biol. 1993 Aug;122(4):961-72 [8394372] J Neurochem. 1994 Jan;62(1):380-3 [7505315] J Comp Neurol. 1994 Apr 15;342(3):321-34 [7912699] Nature. 1995 Jan 26;373(6512):335-9 [7830766] J Cell Biol. 1995 Aug;130(4):977-86 [7642713] Neuroscience. 1996 Jul;73(2):397-406 [8783257] Brain Res. 2008 Jan 2;1187:1-11 [18036511] Ageing Res Rev. 2008 Jan;7(1):8-20 [17768095] Physiol Rev. 2008 Jan;88(1):211-47 [18195087] Curr Opin Pharmacol. 2008 Feb;8(1):104-10 [17962069] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0007812 ER - TY - CPAPER T1 - A Cycle of O-GlcNAcylation Targeting the Human RNA Polymerase II CTD is Necessary for Transcription Initiation T2 - 2009 Annual Meeting of the Society for Glycobiology (Glycobiology 2009) AN - 42077831; 5520711 JF - 2009 Annual Meeting of the Society for Glycobiology (Glycobiology 2009) AU - Lewis, Brian AU - Hart, Gerald AU - Sakabe, Kaoru Y1 - 2009/11/12/ PY - 2009 DA - 2009 Nov 12 KW - DNA-directed RNA polymerase KW - Transcription initiation KW - CTD observations KW - Transcription KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42077831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Society+for+Glycobiology+%28Glycobiology+2009%29&rft.atitle=A+Cycle+of+O-GlcNAcylation+Targeting+the+Human+RNA+Polymerase+II+CTD+is+Necessary+for+Transcription+Initiation&rft.au=Lewis%2C+Brian%3BHart%2C+Gerald%3BSakabe%2C+Kaoru&rft.aulast=Lewis&rft.aufirst=Brian&rft.date=2009-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Society+for+Glycobiology+%28Glycobiology+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/Portals/0/Oral%20Schedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Predicting new molecular targets for known drugs AN - 21289368; 11699959 AB - Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administration (FDA)-approved and investigational drugs against hundreds of targets, defining each target by its ligands. Chemical similarities between drugs and ligand sets predicted thousands of unanticipated associations. Thirty were tested experimentally, including the antagonism of the b sub(1) receptor by the transporter inhibitor Prozac, the inhibition of the 5-hydroxytryptamine (5-HT) transporter by the ion channel drug Vadilex, and antagonism of the histamine H sub(4) receptor by the enzyme inhibitor Rescriptor. Overall, 23 new drug-target associations were confirmed, five of which were potent (<100nM). The physiological relevance of one, the drug N,N-dimethyltryptamine (DMT) on serotonergic receptors, was confirmed in a knockout mouse. The chemical similarity approach is systematic and comprehensive, and may suggest side-effects and new indications for many drugs. JF - Nature AU - Keiser, Michael J AU - Setola, Vincent AU - Irwin, John J AU - Laggner, Christian AU - Abbas, Atheir I AU - Hufeisen, Sandra J AU - Jensen, Niels H AU - Kuijer, Michael B AU - Matos, Roberto C AU - Tran, Thuy B AU - Whaley, Ryan AU - Glennon, Richard A AU - Hert, Jerome AU - Thomas, Kelan LH AU - Edwards, Douglas D AU - Shoichet, Brian K AU - Roth, Bryan L AD - [1] NIMH Psychoactive Drug Screening Program, Department of Pharmacology, [2] Department of Pharmacology and Division of Medicinal Chemistry and Natural Products, The University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27759, USA Y1 - 2009/11/12/ PY - 2009 DA - 2009 Nov 12 SP - 175 EP - 181 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 462 IS - 7270 SN - 0028-0836, 0028-0836 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - enzyme inhibitors KW - antagonism KW - Physiology KW - Enzymes KW - Serotonin KW - Histamine KW - Serotonin receptors KW - histamines KW - Ion channels KW - Drugs KW - Side effects KW - W 30935:Food Biotechnology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21289368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Predicting+new+molecular+targets+for+known+drugs&rft.au=Keiser%2C+Michael+J%3BSetola%2C+Vincent%3BIrwin%2C+John+J%3BLaggner%2C+Christian%3BAbbas%2C+Atheir+I%3BHufeisen%2C+Sandra+J%3BJensen%2C+Niels+H%3BKuijer%2C+Michael+B%3BMatos%2C+Roberto+C%3BTran%2C+Thuy+B%3BWhaley%2C+Ryan%3BGlennon%2C+Richard+A%3BHert%2C+Jerome%3BThomas%2C+Kelan+LH%3BEdwards%2C+Douglas+D%3BShoichet%2C+Brian+K%3BRoth%2C+Bryan+L&rft.aulast=Keiser&rft.aufirst=Michael&rft.date=2009-11-12&rft.volume=462&rft.issue=7270&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature08506 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Serotonin receptors; Ion channels; Enzymes; Serotonin; Side effects; Histamine; enzyme inhibitors; histamines; antagonism; Physiology; Drugs DO - http://dx.doi.org/10.1038/nature08506 ER - TY - JOUR T1 - Is evolution Darwinian or/and Lamarckian? AN - 733579954; 19906303 AB - The year 2009 is the 200th anniversary of the publication of Jean-Bapteste Lamarck's Philosophie Zoologique and the 150th anniversary of Charles Darwin's On the Origin of Species. Lamarck believed that evolution is driven primarily by non-randomly acquired, beneficial phenotypic changes, in particular, those directly affected by the use of organs, which Lamarck believed to be inheritable. In contrast, Darwin assigned a greater importance to random, undirected change that provided material for natural selection. The classic Lamarckian scheme appears untenable owing to the non-existence of mechanisms for direct reverse engineering of adaptive phenotypic characters acquired by an individual during its life span into the genome. However, various evolutionary phenomena that came to fore in the last few years, seem to fit a more broadly interpreted (quasi)Lamarckian paradigm. The prokaryotic CRISPR-Cas system of defense against mobile elements seems to function via a bona fide Lamarckian mechanism, namely, by integrating small segments of viral or plasmid DNA into specific loci in the host prokaryote genome and then utilizing the respective transcripts to destroy the cognate mobile element DNA (or RNA). A similar principle seems to be employed in the piRNA branch of RNA interference which is involved in defense against transposable elements in the animal germ line. Horizontal gene transfer (HGT), a dominant evolutionary process, at least, in prokaryotes, appears to be a form of (quasi)Lamarckian inheritance. The rate of HGT and the nature of acquired genes depend on the environment of the recipient organism and, in some cases, the transferred genes confer a selective advantage for growth in that environment, meeting the Lamarckian criteria. Various forms of stress-induced mutagenesis are tightly regulated and comprise a universal adaptive response to environmental stress in cellular life forms. Stress-induced mutagenesis can be construed as a quasi-Lamarckian phenomenon because the induced genomic changes, although random, are triggered by environmental factors and are beneficial to the organism. Both Darwinian and Lamarckian modalities of evolution appear to be important, and reflect different aspects of the interaction between populations and the environment. JF - Biology direct AU - Koonin, Eugene V AU - Wolf, Yuri I AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. koonin@ncbi.nlm.nih.gov Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 SP - 42 VL - 4 KW - DNA Transposable Elements KW - 0 KW - Index Medicus KW - Inheritance Patterns -- genetics KW - Stress, Physiological -- genetics KW - Mutagenesis -- genetics KW - DNA Transposable Elements -- genetics KW - Selection, Genetic KW - Biological Evolution KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733579954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+direct&rft.atitle=Is+evolution+Darwinian+or%2Fand+Lamarckian%3F&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2009-11-11&rft.volume=4&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Biology+direct&rft.issn=1745-6150&rft_id=info:doi/10.1186%2F1745-6150-4-42 LA - 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http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Designing Evaluation for Complex Multiple-component Funded Research Programs T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42279614; 5624735 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - deAlmeida-Morris, Genevieve Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Research programs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42279614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Designing+Evaluation+for+Complex+Multiple-component+Funded+Research+Programs&rft.au=deAlmeida-Morris%2C+Genevieve&rft.aulast=deAlmeida-Morris&rft.aufirst=Genevieve&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishing a Comparison Set for Evaluating Unsolicited P01s at the National Institute of Environmental Health Sciences T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42278716; 5624562 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Drew, Christie AU - Phelps, Jerry AU - Barnes, Martha Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Environmental health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42278716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Establishing+a+Comparison+Set+for+Evaluating+Unsolicited+P01s+at+the+National+Institute+of+Environmental+Health+Sciences&rft.au=Drew%2C+Christie%3BPhelps%2C+Jerry%3BBarnes%2C+Martha&rft.aulast=Drew&rft.aufirst=Christie&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - It's A Small World After All: Describing and Assessing National Institutes of Health (NIH)-Funded Research in the Context of A Scientific Field T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42277167; 5624563 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Glavin, Sarah AU - Banks, Jamelle AU - Johnson, Paul Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42277167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=It%27s+A+Small+World+After+All%3A+Describing+and+Assessing+National+Institutes+of+Health+%28NIH%29-Funded+Research+in+the+Context+of+A+Scientific+Field&rft.au=Glavin%2C+Sarah%3BBanks%2C+Jamelle%3BJohnson%2C+Paul&rft.aulast=Glavin&rft.aufirst=Sarah&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Loan Repayment Program: Applying Regression Discontinuity to Assess Program Effect T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42277036; 5624564 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Hernandez, Milton AU - Haak, Laure AU - Munshi, Rajan AU - Probus, Matt Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Loans KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42277036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=NIH+Loan+Repayment+Program%3A+Applying+Regression+Discontinuity+to+Assess+Program+Effect&rft.au=Hernandez%2C+Milton%3BHaak%2C+Laure%3BMunshi%2C+Rajan%3BProbus%2C+Matt&rft.aulast=Hernandez&rft.aufirst=Milton&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating a Program That Disseminates Research-based Education Materials T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42273367; 5623695 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - deAlmeida-Morris, Genevieve Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Education KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42273367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Evaluating+a+Program+That+Disseminates+Research-based+Education+Materials&rft.au=deAlmeida-Morris%2C+Genevieve&rft.aulast=deAlmeida-Morris&rft.aufirst=Genevieve&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. AN - 734134031; 19826128 AB - PURPOSE Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic agents active in T-cell lymphoma, the histone deacetylase inhibitors. On the basis of observed responses in a phase I trial, a phase II trial of romidepsin in patients with T-cell lymphoma was initiated. PATIENTS AND METHODS The initial cohort was limited to patients with cutaneous T-cell lymphoma (CTCL), or subtypes mycosis fungoides or Sézary syndrome, who had received no more than two prior cytotoxic regimens. There were no limits on other types of therapy. Subsequently, the protocol was expanded to enroll patients who had received more than two prior cytotoxic regimens. Results Twenty-seven patients were enrolled onto the first cohort, and a total of 71 patients are included in this analysis. These patients had undergone a median of four prior treatments, and 62 patients (87%) had advanced-stage disease (stage IIB, n = 15; stage III, n= 6; or stage IV, n = 41). Toxicities included nausea, vomiting, fatigue, and transient thrombocytopenia and granulocytopenia. Pharmacokinetics were evaluated with the first administration of romidepsin. Complete responses were observed in four patients, and partial responses were observed in 20 patients for an overall response rate of 34% (95% CI, 23% to 46%). The median duration of response was 13.7 months. CONCLUSION The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Piekarz, Richard L AU - Frye, Robin AU - Turner, Maria AU - Wright, John J AU - Allen, Steven L AU - Kirschbaum, Mark H AU - Zain, Jasmine AU - Prince, H Miles AU - Leonard, John P AU - Geskin, Larisa J AU - Reeder, Craig AU - Joske, David AU - Figg, William D AU - Gardner, Erin R AU - Steinberg, Seth M AU - Jaffe, Elaine S AU - Stetler-Stevenson, Maryalice AU - Lade, Stephen AU - Fojo, A Tito AU - Bates, Susan E AD - Departmentof Health and Human Services, Center for Cancer Researchand Cancer Therapy EvaluationProgram, National Cancer Institute,National Institutes of Health, Bethesda, USA. rpiekarz@nih.gov Y1 - 2009/11/10/ PY - 2009 DA - 2009 Nov 10 SP - 5410 EP - 5417 VL - 27 IS - 32 KW - Antibiotics, Antineoplastic KW - 0 KW - Depsipeptides KW - Histone Deacetylase Inhibitors KW - romidepsin KW - CX3T89XQBK KW - Index Medicus KW - Leukemia -- chemically induced KW - Area Under Curve KW - Humans KW - Fatigue -- chemically induced KW - Metabolic Clearance Rate KW - Aged KW - Antibiotics, Antineoplastic -- pharmacokinetics KW - Antibiotics, Antineoplastic -- therapeutic use KW - Nausea -- chemically induced KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Thrombocytopenia -- chemically induced KW - Middle Aged KW - Antibiotics, Antineoplastic -- adverse effects KW - Female KW - Male KW - Histone Deacetylase Inhibitors -- adverse effects KW - Depsipeptides -- pharmacokinetics KW - Depsipeptides -- adverse effects KW - Histone Deacetylase Inhibitors -- therapeutic use KW - Histone Deacetylase Inhibitors -- pharmacokinetics KW - Lymphoma, T-Cell, Cutaneous -- pathology KW - Depsipeptides -- therapeutic use KW - Lymphoma, T-Cell, Cutaneous -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734134031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+multi-institutional+trial+of+the+histone+deacetylase+inhibitor+romidepsin+as+monotherapy+for+patients+with+cutaneous+T-cell+lymphoma.&rft.au=Piekarz%2C+Richard+L%3BFrye%2C+Robin%3BTurner%2C+Maria%3BWright%2C+John+J%3BAllen%2C+Steven+L%3BKirschbaum%2C+Mark+H%3BZain%2C+Jasmine%3BPrince%2C+H+Miles%3BLeonard%2C+John+P%3BGeskin%2C+Larisa+J%3BReeder%2C+Craig%3BJoske%2C+David%3BFigg%2C+William+D%3BGardner%2C+Erin+R%3BSteinberg%2C+Seth+M%3BJaffe%2C+Elaine+S%3BStetler-Stevenson%2C+Maryalice%3BLade%2C+Stephen%3BFojo%2C+A+Tito%3BBates%2C+Susan+E&rft.aulast=Piekarz&rft.aufirst=Richard&rft.date=2009-11-10&rft.volume=27&rft.issue=32&rft.spage=5410&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.21.6150 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-06 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Dermatol. 1995 Jul;133(1):6-12 [7669641] Ann Intern Med. 1994 Oct 15;121(8):592-602 [8085692] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6791-6 [9618491] Exp Cell Res. 1998 May 25;241(1):126-33 [9633520] J Am Acad Dermatol. 1999 Mar;40(3):418-25 [10071312] J Am Acad Dermatol. 1999 Jun;40(6 Pt 1):914-24 [10365922] Biol Pharm Bull. 2005 Jan;28(1):124-9 [15635176] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3697-702 [15738394] J Clin Invest. 2005 Apr;115(4):798-812 [15841167] J Am Acad Dermatol. 2005 Sep;53(3):428-34 [16112348] Clin Cancer Res. 2006 Jun 15;12(12):3762-73 [16778104] Cancer J. 2007 Jan-Feb;13(1):30-9 [17464244] Arch Dermatol. 2007 Jul;143(7):854-9 [17638728] J Clin Oncol. 2007 Jul 20;25(21):3109-15 [17577020] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Apr 1;865(1-2):153-8 [18342585] Clin Cancer Res. 2008 Jul 15;14(14):4500-10 [18628465] Clin Lymphoma Myeloma. 2008 Aug;8(4):249-52 [18765314] Clin Cancer Res. 2009 Feb 15;15(4):1496-503 [19228751] J Clin Oncol. 1999 Apr;17(4):1244 [10561185] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] J Natl Cancer Inst. 2000 Aug 2;92(15):1210-6 [10922406] Br J Cancer. 2000 Sep;83(6):817-25 [10952788] Blood. 2001 Nov 1;98(9):2865-8 [11675364] Clin Cancer Res. 2002 Mar;8(3):718-28 [11895901] Leuk Lymphoma. 2002 Jun;43(6):1297-302 [12152999] J Exp Ther Oncol. 2002 Nov-Dec;2(6):325-32 [12440223] Cancer Cell. 2003 Jul;4(1):13-8 [12892709] Hematol Oncol Clin North Am. 2003 Dec;17(6):1367-89, viii [14710890] Curr Pharm Des. 2004;10(19):2289-98 [15279609] Cancer Treat Rep. 1979 Apr;63(4):725-8 [445521] Ann Intern Med. 1988 Sep 1;109(5):372-82 [3408055] Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] Lancet. 1991 Feb 2;337(8736):268-9 [1671113] JAMA. 1992 Mar 11;267(10):1354-8 [1740857] J Antibiot (Tokyo). 1994 Mar;47(3):301-10 [7513682] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5705-8 [8650156] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1200/JCO.2008.21.6150 ER - TY - JOUR T1 - Induced expression of drug metabolizing enzymes by preventive agents: Role of the antioxidant response element AN - 21203083; 11182669 AB - Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats was examined. Sprague-Dawley rats were treated for 7 days with various agents in the diet or by gavage. The agents examined, which might be expected to respond via specific nuclear receptors (CAR, AhR) as well as antioxidant response elements (AREs), included Phase I/II inducers [5,6-benzoflavone (BF, 5000 mg/kg diet), diallyl sulfide (DAS, 500 mg/kg BW/day), ethoxyquin (EXO, 300 mg/kg BW/day) and phenobarbital (PB, 500 mg/kg diet)] or pure Phase II inducers [1,2-dithiol-3-thione (DTT, 500 mg/kg diet), and cyclopentadithiolthione (CPDTT, 175 mg/kg BW/day)]. Liver RNA expression was analyzed employing oligonucleotide microarrays. The agents yielded unique expression profiles. In genes with known AREs, the induction ratios (Levels Treated/Levels Controls) were: quinone oxidoreductase (BF, 8:1; DTT, 3.2:1; CPDTT, 3:1; DAS, 1.8:1; Exo, 1.7:1), glutatione transferase Pi (DTT, 36:1; CPDTT, 34:1; EXO, 8:1; DAS, 5:1; BF, 2.5:1), and aldehyde keto reductase 7A3 (AFAR) (DTT and CPDTT, 14:1; DAS, 6:1; EXO, 4:1; PB, 1.5:1). When the search included a wider variety of Phase II drug metabolizing enzymes, no clear pattern was observed. Agent induced gene expression and preventive activity in published carcinogen induced tumor models showed limited correlation; questioning whether measuring the induction of one or two genes (e.g., quinone reductase) is a surrogate for overall Phase II inducing (antioxidant) and potential anti-tumor activity. JF - Chemico-Biological Interactions AU - Lubet, Ronald A AU - Yao, Ruisheng AU - Grubbs, Clinton J AU - You, Ming AU - Wang, Yian AD - Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA, lubetr@mail.nih.gov Y1 - 2009/11/10/ PY - 2009 DA - 2009 Nov 10 SP - 22 EP - 28 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 182 IS - 1 SN - 0009-2797, 0009-2797 KW - Toxicology Abstracts KW - Diets KW - Phenobarbital KW - Antioxidants KW - Regulatory sequences KW - Nuclear receptors KW - Enzymes KW - Carcinogens KW - Tumors KW - DNA microarrays KW - Antitumor agents KW - Oligonucleotides KW - Cancer KW - Models KW - Sulfide KW - ethoxyquin KW - reductase KW - RNA KW - Liver KW - NAD(P)H dehydrogenase (quinone) KW - Aldehydes KW - Dithiothreitol KW - quinone oxidoreductase KW - Drugs KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21203083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=Induced+expression+of+drug+metabolizing+enzymes+by+preventive+agents%3A+Role+of+the+antioxidant+response+element&rft.au=Lubet%2C+Ronald+A%3BYao%2C+Ruisheng%3BGrubbs%2C+Clinton+J%3BYou%2C+Ming%3BWang%2C+Yian&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2009-11-10&rft.volume=182&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Chemico-Biological+Interactions&rft.issn=00092797&rft_id=info:doi/10.1016%2Fj.cbi.2009.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Phenobarbital; Antioxidants; Nuclear receptors; Regulatory sequences; Enzymes; Tumors; Carcinogens; Oligonucleotides; Antitumor agents; DNA microarrays; Cancer; Models; Sulfide; ethoxyquin; reductase; RNA; Liver; NAD(P)H dehydrogenase (quinone); quinone oxidoreductase; Dithiothreitol; Aldehydes; Drugs DO - http://dx.doi.org/10.1016/j.cbi.2009.08.011 ER - TY - JOUR T1 - Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3,3',4,4'-tetrachloroazobenzene for 2 years AN - 21105299; 11143163 AB - Exposure to dioxin and dioxin-like compounds (DLCs) has been connected to the induction of chloracne in humans and animals. 3,3',4,4'-Tetrachloroazobenzene (TCAB) is an environmental contaminant that induces chloracne in humans. TCAB has been studied only to a limited extent in laboratory animals. While performing a 2-year gavage study in B6C3F1 mice to evaluate the toxic and carcinogenic effects of TCAB, we also explored potential chloracnegenic properties. Groups of 50 male and 50 female B6C3F1 mice were exposed by gavage to TCAB at dose levels of 0, 3, 10 and 30mg/kg for 5 days a week for 2 years. The animals developed treatment-related gross inflammatory skin lesions, which were characterized histologically by inflammation, fibrosis, hyperplasia, and ulcers. Additionally, many of the animals developed follicular dilatation and sebaceous gland atrophy, consistent with chloracne-like lesions. This current 2-year study supports recently published papers showing susceptibility to chloracne in mouse strains other than hairless mice. The chloracne-like lesions were not clinically evident; therefore, our study highlights the need for careful examination of the skin in order to identify subtle lesions consistent with chloracne-like changes in rodents exposed to dioxin and DLCs. Since previous short-term studies did not demonstrate any skin lesions, we suggest that reliable assessment of all safety issues involving dioxin and DLCs requires evaluation following chronic exposure. Such studies in animal models will help to elucidate the mechanisms of dioxin-related health hazards. JF - Toxicology AU - Ramot, Y AU - Nyska, A AU - Lieuallen, W AU - Maly, A AU - Flake, G AU - Kissling, GE AU - Brix, A AU - Malarkey, DE AU - Hooth, MJ AD - National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC 27709, USA, hooth@niehs.nih.gov Y1 - 2009/11/09/ PY - 2009 DA - 2009 Nov 09 SP - 1 EP - 9 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 265 IS - 1-2 SN - 0300-483X, 0300-483X KW - Environment Abstracts; Toxicology Abstracts KW - Chloracne KW - Skin KW - Laboratory testing KW - Fibrosis KW - Laboratory animals KW - Animal models KW - Mice KW - Dioxins KW - Sebaceous gland KW - Inflammation KW - Hyperplasia KW - Skin diseases KW - Carcinogenicity KW - Chronic exposure KW - Ulcers KW - Lesions KW - Hairless KW - Atrophy KW - Contaminants KW - rodents KW - Dioxin KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21105299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Inflammatory+and+chloracne-like+skin+lesions+in+B6C3F1+mice+exposed+to+3%2C3%27%2C4%2C4%27-tetrachloroazobenzene+for+2+years&rft.au=Ramot%2C+Y%3BNyska%2C+A%3BLieuallen%2C+W%3BMaly%2C+A%3BFlake%2C+G%3BKissling%2C+GE%3BBrix%2C+A%3BMalarkey%2C+DE%3BHooth%2C+MJ&rft.aulast=Ramot&rft.aufirst=Y&rft.date=2009-11-09&rft.volume=265&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2009.08.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Chloracne; Fibrosis; Animal models; Laboratory animals; Sebaceous gland; Inflammation; Hyperplasia; Skin diseases; Ulcers; Chronic exposure; Atrophy; Hairless; Contaminants; Dioxin; Skin; Laboratory testing; Carcinogenicity; Lesions; Mice; rodents; Dioxins DO - http://dx.doi.org/10.1016/j.tox.2009.08.017 ER - TY - JOUR T1 - Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo. AN - 734141692; 19895691 AB - WR1065 is the free-thiol metabolite of the cytoprotective aminothiol amifostine, which is used clinically at very high doses to protect patients against toxicity induced by radiation and chemotherapy. In an earlier study we briefly reported that the aminothiol WR1065 also inhibits HIV-1 replication in phytohemagglutinin (PHA)-stimulated human T-cell blasts (TCBs) infected in culture for 2 hr before WR1065 exposure. In this study we expanded the original observations to define the dose-response curve for that inhibition, and address the question of additive effects for the combination of WR1065 plus Zidovudine (AZT). Here we also explored the effect of WR1065 on SIV by examining TCBs taken from macaques with well-established infections several months with SIV. TCBs from healthy human donors were infected for 2 hr with HIV-1, and viral replication (p24) was measured after 72 hr of incubation with or without WR1065, AZT, or both drugs. HIV-1 replication, in HIV-1-infected human TCBs, was inhibited by 50% at 13 microM WR1065, a dose at which 80% of the cells were viable. Cell cycle parameters were the same or equivalent at 0, 9.5 and 18.7 microM WR1065, showing no drug-related toxicity. Combination of AZT with WR1065 showed that AZT retained antiretroviral potency in the presence of WR1065. Cultured CD8+ T cell-depleted PHA-stimulated TCBs from Macaca mulatta monkeys chronically infected with SIV were incubated 17 days with WR1065, and viral replication (p27) and cell viability were determined. Complete inhibition (100%) of SIV replication (p27) was observed when TCBs from 3 monkeys were incubated for 17 days with 18.7 microM WR1065. A lower dose, 9.5 microM WR1065, completely inhibited SIV replication in 2 of the 3 monkeys, but cells from the third macaque, with the highest viral titer, only responded at the high WR1065 dose. The study demonstrates that WR1065 and the parent drug amifostine, the FDA-approved drug Ethyol, have antiretroviral activity. WR1065 was active against both an acute infection of HIV-1 and a chronic infection of SIV. The data suggest that the non-toxic drug amifostine may be a useful antiretroviral agent given either alone or in combination with other drugs as adjuvant therapy. JF - AIDS research and therapy AU - Poirier, Miriam C AU - Olivero, Ofelia A AU - Hardy, Andrew W AU - Franchini, Genoveffa AU - Borojerdi, Jennifer P AU - Walker, Vernon E AU - Walker, Dale M AU - Shearer, Gene M AD - CDI Section, LCBG, CCR, National Cancer Institute, NIH, Bethesda, MD 20892, USA. poirierm@exchange.nih.gov Y1 - 2009/11/06/ PY - 2009 DA - 2009 Nov 06 SP - 24 VL - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734141692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+therapy&rft.atitle=Antiretroviral+activity+of+the+aminothiol+WR1065+against+Human+Immunodeficiency+virus+%28HIV-1%29+in+vitro+and+Simian+Immunodeficiency+virus+%28SIV%29+ex+vivo.&rft.au=Poirier%2C+Miriam+C%3BOlivero%2C+Ofelia+A%3BHardy%2C+Andrew+W%3BFranchini%2C+Genoveffa%3BBorojerdi%2C+Jennifer+P%3BWalker%2C+Vernon+E%3BWalker%2C+Dale+M%3BShearer%2C+Gene+M&rft.aulast=Poirier&rft.aufirst=Miriam&rft.date=2009-11-06&rft.volume=6&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+therapy&rft.issn=1742-6405&rft_id=info:doi/10.1186%2F1742-6405-6-24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Mol Mutagen. 2009 Jul;50(6):460-72 [19334055] Cancer Chemother Pharmacol. 1999;44(6):498-504 [10550571] Curr HIV/AIDS Rep. 2009 May;6(2):68-76 [19358777] Science. 2009 Mar 6;323(5919):1304-7 [19265012] Curr Opin Drug Discov Devel. 2009 Jan;12(1):53-60 [19152213] Clin Infect Dis. 2009 Jan 15;48(2):214-21 [19072245] JAMA. 2008 Aug 6;300(5):555-70 [18677028] J Antimicrob Chemother. 2008 Jan;61(1):8-12 [17999978] AIDS. 2007 May 11;21(8):929-38 [17457086] Pediatr Blood Cancer. 2007 May;48(5):579-81 [16395679] Anticancer Res. 2006 May-Jun;26(3B):2437-43 [16821629] Pharmacol Rep. 2006 Jan-Feb;58(1):30-4 [16531627] Blood. 2005 Nov 15;106(10):3524-31 [16046522] Oncogene. 2005 Jun 2;24(24):3964-75 [15750621] Oncology. 2004;67(3-4):187-93 [15557777] AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S311-9 [9814959] J Virol. 1998 Oct;72(10):7992-8001 [9733838] Chem Biol Interact. 1994 Jun;91(2-3):217-24 [8194136] Carcinogenesis. 1995 Apr;16(4):767-74 [7728953] Cancer Res. 1995 Sep 15;55(18):4069-72 [7664282] AIDS Res Hum Retroviruses. 1994 Jun;10(6):727-33 [7521193] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4559-63 [8183947] AIDS Res Hum Retroviruses. 1992 Jul;8(7):1249-53 [1520537] Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):986-90 [1704137] Carcinogenesis. 1985 Jun;6(6):929-31 [4006082] Drug Metab Dispos. 1990 May-Jun;18(3):281-7 [1974187] Blood. 2004 Mar 1;103(5):1586-94 [14592831] AIDS. 2003 Aug 15;17(12):1769-85 [12891063] J Biol Chem. 2003 Apr 4;278(14):11879-87 [12531896] Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):180-9 [12007958] Mil Med. 2002 Feb;167(2 Suppl):51-3 [11873516] J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73 [11356930] Drug Metabol Drug Interact. 2000;16(4):237-79 [11201306] Cancer Res. 2000 Mar 1;60(5):1186-8 [10728671] Antivir Ther. 2009;14(2):165-79 [19430091] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-6405-6-24 ER - TY - CPAPER T1 - Liquid Chromatography/Tandem Mass Spectrometry Method To Rapid Asses the Irinotecan Metabolic Phenotype T2 - Inaugural Mass Spec Europe Conference and Exhibition AN - 42112700; 5539845 JF - Inaugural Mass Spec Europe Conference and Exhibition AU - Corona, Giuseppe Y1 - 2009/11/05/ PY - 2009 DA - 2009 Nov 05 KW - Mass spectroscopy KW - Liquid chromatography KW - Irinotecan KW - Chromatography KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42112700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Inaugural+Mass+Spec+Europe+Conference+and+Exhibition&rft.atitle=Liquid+Chromatography%2FTandem+Mass+Spectrometry+Method+To+Rapid+Asses+the+Irinotecan+Metabolic+Phenotype&rft.au=Corona%2C+Giuseppe&rft.aulast=Corona&rft.aufirst=Giuseppe&rft.date=2009-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Inaugural+Mass+Spec+Europe+Conference+and+Exhibition&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/MSE2009/Poster.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Accounting for Near-Normal Glucose Sensitivity in K sub(ir)6.2[AAA] Transgenic Mice AN - 787285187; 13713962 AB - K sub(ir)6.2[AAA] transgenic mouse islets exhibit mosaicism such that [not, vert, similar]70% of the b-cells have nonfunctional ATP-sensitive potassium (K sub(ATP)) channels, whereas the remainder have normal K sub(ATP) function. Despite this drastic reduction, the glucose dose-response curve is only shifted by [not, vert, similar]2 mM. We use a previously published mathematical model, in which K sub(ATP) conductance is increased by rises in cytosolic calcium through indirect effects on metabolism, to investigate how cells could compensate for the loss of K sub(ATP) conductance. Compensation is favored by the assumption that only a small fraction of K sub(ATP) channels are open during oscillations, which renders it easy to upregulate the open fraction via a modest elevation of calcium. We show further that strong gap-junctional coupling of both membrane potential and calcium is needed to overcome the stark heterogeneity of cell properties in these mosaic islets. JF - Biophysical Journal AU - Tsaneva-Atanasova, Krasimira AU - Sherman, Arthur AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, asherman@nih.gov Y1 - 2009/11/04/ PY - 2009 DA - 2009 Nov 04 SP - 2409 EP - 2418 PB - Biophysical Society VL - 97 IS - 9 SN - 0006-3495, 0006-3495 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Calcium KW - Lymphocytes B KW - Conductance KW - Glucose KW - Potassium KW - Islets of Langerhans KW - Transgenic mice KW - Potassium channels (inwardly-rectifying) KW - Mosaicism KW - Mosaics KW - Calcium signalling KW - Potassium channels KW - Metabolism KW - Membrane potential KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787285187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=Accounting+for+Near-Normal+Glucose+Sensitivity+in+K+sub%28ir%296.2%5BAAA%5D+Transgenic+Mice&rft.au=Tsaneva-Atanasova%2C+Krasimira%3BSherman%2C+Arthur&rft.aulast=Tsaneva-Atanasova&rft.aufirst=Krasimira&rft.date=2009-11-04&rft.volume=97&rft.issue=9&rft.spage=2409&rft.isbn=&rft.btitle=&rft.title=Biophysical+Journal&rft.issn=00063495&rft_id=info:doi/10.1016%2Fj.bpj.2009.07.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Calcium; Mathematical models; Conductance; Lymphocytes B; Glucose; Potassium; Islets of Langerhans; Transgenic mice; Potassium channels (inwardly-rectifying); Mosaicism; Mosaics; Calcium signalling; Potassium channels; Metabolism; Membrane potential DO - http://dx.doi.org/10.1016/j.bpj.2009.07.060 ER - TY - CPAPER T1 - Sickle Cell Anemia: Yesterday, Today, and Tomorrow T2 - 2009 Annual Biomedical Research Conference for Minority Students (ABRCMS 2009) AN - 42118485; 5535220 JF - 2009 Annual Biomedical Research Conference for Minority Students (ABRCMS 2009) AU - Rodgers, Griffin Y1 - 2009/11/04/ PY - 2009 DA - 2009 Nov 04 KW - Anemia KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42118485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Biomedical+Research+Conference+for+Minority+Students+%28ABRCMS+2009%29&rft.atitle=Sickle+Cell+Anemia%3A+Yesterday%2C+Today%2C+and+Tomorrow&rft.au=Rodgers%2C+Griffin&rft.aulast=Rodgers&rft.aufirst=Griffin&rft.date=2009-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Biomedical+Research+Conference+for+Minority+Students+%28ABRCMS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abrcms.org/documents/2009FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Processing and Enzymatic Activities of Truncated Mutants of the Lysophosphatidic-Acid-Producing Exoenzyme Autotaxin T2 - 2009 Annual Biomedical Research Conference for Minority Students (ABRCMS 2009) AN - 42108727; 5535228 JF - 2009 Annual Biomedical Research Conference for Minority Students (ABRCMS 2009) AU - Zukowski, Alexis Y1 - 2009/11/04/ PY - 2009 DA - 2009 Nov 04 KW - Enzymatic activity KW - Mutants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42108727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Biomedical+Research+Conference+for+Minority+Students+%28ABRCMS+2009%29&rft.atitle=Processing+and+Enzymatic+Activities+of+Truncated+Mutants+of+the+Lysophosphatidic-Acid-Producing+Exoenzyme+Autotaxin&rft.au=Zukowski%2C+Alexis&rft.aulast=Zukowski&rft.aufirst=Alexis&rft.date=2009-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Biomedical+Research+Conference+for+Minority+Students+%28ABRCMS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abrcms.org/documents/2009FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - We Need All The Help We Can Get! -- Standards That Assist in Electronic Resources Management T2 - XXIX Annual Charleston Conference AN - 42088105; 5526225 JF - XXIX Annual Charleston Conference AU - Landesman, Betty Y1 - 2009/11/04/ PY - 2009 DA - 2009 Nov 04 KW - Resource management KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42088105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIX+Annual+Charleston+Conference&rft.atitle=We+Need+All+The+Help+We+Can+Get%21+--+Standards+That+Assist+in+Electronic+Resources+Management&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2009-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIX+Annual+Charleston+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.katina.info/conference/downloads/FullProgramFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health Study AN - 21331969; 11699369 AB - Background:Certain studies suggest that alcohol may reduce the risk of thyroid cancer in women, but the effect in men remains unclear. Methods:We analysed the association between alcohol and thyroid cancer in a large (n=490159) prospective NIH-AARP Diet and Health Study with self-reported beer, wine, and liquor intakes. Results:Over 7.5 years of follow-up (median), 170 men and 200 women developed thyroid cancer. Overall, the thyroid cancer risk decreased with greater alcohol consumption (.2 drinks per day vs none, relative risk=0.57, 95% CI 0.36-0.89, P-trend=0.01). Conclusions:These results suggest a potential protective role for alcohol consumption in thyroid cancer. JF - British Journal of Cancer AU - Meinhold, C L AU - Park, Y AU - Stolzenberg-Solomon, R Z AU - Hollenbeck, A R AU - Schatzkin, A AU - Berrington de Gonzalez, A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA Y1 - 2009/11/03/ PY - 2009 DA - 2009 Nov 03 SP - 1630 EP - 1634 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 9 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Diets KW - Alcohol KW - risk reduction KW - Thyroid KW - Vitaceae KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21331969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Alcohol+intake+and+risk+of+thyroid+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Meinhold%2C+C+L%3BPark%2C+Y%3BStolzenberg-Solomon%2C+R+Z%3BHollenbeck%2C+A+R%3BSchatzkin%2C+A%3BBerrington+de+Gonzalez%2C+A&rft.aulast=Meinhold&rft.aufirst=C&rft.date=2009-11-03&rft.volume=101&rft.issue=9&rft.spage=1630&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605337 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Alcohol; Thyroid; Cancer; Vitaceae DO - http://dx.doi.org/10.1038/sj.bjc.6605337 ER - TY - JOUR T1 - PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. AN - 734090673; 19717351 AB - By limiting cell cycle progression following detection of DNA damage, checkpoints are critical for cell survival and genome stability. Methylated DNA damage, when combined with inhibition of PARP activity, results in an ATR-dependent S phase delay of the cell cycle. Here, we demonstrate that another checkpoint kinase, ATM, also is involved in the DNA damage response following treatment with a sub-lethal concentration of MMS combined with the PARP inhibitor 4-AN. Both ATM and PARP activities are important for moderating cellular sensitivity to MMS. Loss of ATM activity, or that of its downstream effector Chk2, limited the duration of the S phase delay. The combination of MMS and 4-AN resulted in ATM and Chk2 phosphorylation and the time course of phosphorylation for both kinases correlated with the S phase delay. Chk2 phosphorylation was reduced in the absence of ATM activity. The Chk2 phosphorylation that remained in the absence of ATM appeared to be dependent on ATR and DNA-PK. The results demonstrate that, following initiation of base excision repair and inhibition of PARP activity, ATM activation is critical for preventing the cell from progressing through S phase, and for protection against MMS-induced cytotoxicity. JF - DNA repair AU - Carrozza, Michael J AU - Stefanick, Donna F AU - Horton, Julie K AU - Kedar, Padmini S AU - Wilson, Samuel H AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2009/11/02/ PY - 2009 DA - 2009 Nov 02 SP - 1264 EP - 1272 VL - 8 IS - 11 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Naphthalimides KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Quinolones KW - Tumor Suppressor Proteins KW - 4-amino-1,8-naphthalimide KW - 1742-95-6 KW - 1-Naphthylamine KW - 9753I242R5 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Checkpoint Kinase 2 KW - EC 2.7.1.11 KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - CHEK2 protein, human KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - 1-Naphthylamine -- analogs & derivatives KW - Phosphorylation KW - Humans KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Alkylation -- drug effects KW - 1-Naphthylamine -- pharmacology KW - Naphthalimides -- pharmacology KW - Cell Line KW - Quinolones -- pharmacology KW - Methyl Methanesulfonate -- pharmacology KW - Protein-Serine-Threonine Kinases -- metabolism KW - DNA Damage KW - Tumor Suppressor Proteins -- metabolism KW - Cell Cycle -- drug effects KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734090673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=PARP+inhibition+during+alkylation-induced+genotoxic+stress+signals+a+cell+cycle+checkpoint+response+mediated+by+ATM.&rft.au=Carrozza%2C+Michael+J%3BStefanick%2C+Donna+F%3BHorton%2C+Julie+K%3BKedar%2C+Padmini+S%3BWilson%2C+Samuel+H&rft.aulast=Carrozza&rft.aufirst=Michael&rft.date=2009-11-02&rft.volume=8&rft.issue=11&rft.spage=1264&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=1568-7856&rft_id=info:doi/10.1016%2Fj.dnarep.2009.07.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-02 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2004 Dec 15;64(24):9152-9 [15604286] J Cell Physiol. 2005 Feb;202(2):492-502 [15389585] J Biol Chem. 2005 Mar 25;280(12):12041-50 [15668230] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] J Biol Chem. 2005 Apr 22;280(16):15773-85 [15701627] Cell Mol Life Sci. 2005 Apr;62(7-8):731-8 [15868398] Curr Pharm Des. 2005;11(22):2855-72 [16101442] Trends Mol Med. 2005 Oct;11(10):456-63 [16154385] Nat Cell Biol. 2006 Jan;8(1):37-45 [16327781] Nucleic Acids Res. 2006;34(6):1685-91 [16556909] Trends Biochem Sci. 2006 Jul;31(7):402-10 [16774833] J Cell Physiol. 2006 Sep;208(3):613-9 [16741947] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] BMC Mol Biol. 2007;8:29 [17459151] DNA Repair (Amst). 2007 Jun 1;6(6):742-50 [17292679] J Biol Chem. 2007 Jun 1;282(22):16441-53 [17428792] DNA Repair (Amst). 2007 Jul 1;6(7):953-66 [17531546] Clin Cancer Res. 2007 Nov 1;13(21):6252-6 [17975135] Cell Res. 2008 Jan;18(1):48-63 [18166976] J Biol Chem. 2008 Jan 11;283(2):1197-208 [18025084] DNA Repair (Amst). 2008 Jun 1;7(6):849-57 [18375193] DNA Repair (Amst). 2008 Jun 1;7(6):932-40 [18472309] Cell Mol Life Sci. 2008 May;65(10):1544-65 [18259689] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Clin Cancer Res. 2008 Dec 1;14(23):7917-23 [19047122] Mol Cell. 1999 Oct;4(4):511-8 [10549283] J Biol Chem. 2000 Apr 7;275(14):10342-8 [10744722] Nature. 2000 Jun 15;405(6788):807-10 [10866204] Mol Cell. 2001 Feb;7(2):263-72 [11239455] Mol Cell Biol. 2001 Jul;21(13):4129-39 [11390642] J Biol Chem. 2001 Jul 6;276(27):25541-8 [11340072] J Biol Chem. 2001 Nov 9;276(45):42462-7 [11571274] J Biol Chem. 2002 Aug 23;277(34):31115-23 [12063248] DNA Repair (Amst). 2002 Apr 29;1(4):317-33 [12509250] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] Nature. 2003 Jan 30;421(6922):499-506 [12556884] Mutat Res. 2003 Nov 27;532(1-2):85-102 [14643431] Cancer Res. 2004 Apr 1;64(7):2390-6 [15059890] Mutat Res. 1982 Jun;94(2):369-82 [6810166] Anal Biochem. 1984 Aug 15;141(1):70-3 [6496937] Nature. 1992 Mar 26;356(6367):356-8 [1549180] J Biol Chem. 1993 Mar 15;268(8):5480-7 [7680646] Biochemistry. 1994 Jun 14;33(23):7099-106 [8003475] Nature. 1996 Jan 11;379(6561):183-6 [8538772] Oncogene. 1997 Jul 10;15(2):159-67 [9244351] J Biol Chem. 1998 Jan 9;273(2):898-902 [9422747] EMBO J. 1998 Jan 2;17(1):159-69 [9427750] Cancer Res. 1999 Sep 1;59(17):4375-82 [10485486] Hum Mol Genet. 2004 Dec 1;13(23):2937-45 [15459181] J Med Chem. 2005 Mar 24;48(6):1873-85 [15771432] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2009.07.010 ER - TY - JOUR T1 - Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice AN - 883033553; 15241869 AB - In an effort to understand the disposition and toxicokinetics of nanoscale materials, we used EDS (energy dispersive X-ray spectroscopy) to detect and map the distribution of titanium dioxide (TiO2) in tissue sections from mice following either subcutaneous (s.c.) or intravenous (i.v.) injection. TiO2 nanoparticles were administered at a dose of 560 mg/kg (i.v.) or 5600 mg/kg (s.c.) to Balb/c female mice on two consecutive days. Tissues (liver, kidney, lung, heart, spleen, and brain) were examined by light microscopy, TEM (transmission electron microscopy), SEM (scanning electron microscopy), and EDS following necropsy one day after treatment. Particle agglomerates were detected by light microsopy in all tissues examined, EDS microanalysis was used to confirm that these tissues contained elemental titanium and oxygen. The TEM micrographs and EDS spectra of the aggregates were compared with in vitro measurements of TiO2 nanoparticle injection solution (i.e., in water). The nanoparticles were also characterized using dynamic light scattering in water, 10 mM NaCl, and phosphate buffered saline (PBS). In low ionic strength solvents (water and 10 mM NaCl), the TiO2 particles had average hydrodynamic diameters ranging from 114-122 nm. In PBS, however, the average diameter increases to 1-2 mu m, likely due to aggregation analogous to that observed in tissue by TEM and EDS. This investigation demonstrates the suitability of energy dispersive X-ray spectroscopy (EDS) for detection of nanoparticle aggregates in tissues and shows that disposition of TiO2 nanoparticles depends on the route of administration (i.v. or s.c.). Published in 2009 by John Wiley and Sons, Ltd. JF - Journal of Applied Toxicology AU - Patri, Anil AU - Umbreit, Thomas AU - Zheng, J AU - Nagashima, K AU - Goering, Peter AU - Francke-Carroll, Sabine AU - Gordon, Edward AU - Weaver, James AU - Miller, Terry AU - Sadrieh, Nakissa AU - McNeil, Scott AU - Stratmeyer, Mel AD - Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA, thomas.umbreit@fda.hhs.gov thomas.umbreit@fda.hhs.gov thomas.umbreit@fda.hhs.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 662 EP - 672 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 8 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts KW - Autopsy KW - Hydrodynamics KW - titanium dioxide KW - Transmission electron microscopy KW - Light scattering KW - Particulates KW - Spectroscopy KW - Titanium dioxide KW - Sodium chloride KW - Heart KW - Titanium KW - Intravenous administration KW - Brain KW - Solvents KW - Spleen KW - Mice KW - Disposition KW - Phosphates KW - Phosphate KW - Lung KW - Ionizing radiation KW - Energy KW - Microscopy KW - X-ray spectroscopy KW - Kidney KW - nanoparticles KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883033553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Energy+dispersive+X-ray+analysis+of+titanium+dioxide+nanoparticle+distribution+after+intravenous+and+subcutaneous+injection+in+mice&rft.au=Patri%2C+Anil%3BUmbreit%2C+Thomas%3BZheng%2C+J%3BNagashima%2C+K%3BGoering%2C+Peter%3BFrancke-Carroll%2C+Sabine%3BGordon%2C+Edward%3BWeaver%2C+James%3BMiller%2C+Terry%3BSadrieh%2C+Nakissa%3BMcNeil%2C+Scott%3BStratmeyer%2C+Mel&rft.aulast=Patri&rft.aufirst=Anil&rft.date=2009-11-01&rft.volume=29&rft.issue=8&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1454 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1454/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Autopsy; Intravenous administration; Titanium; Hydrodynamics; Transmission electron microscopy; Light scattering; Solvents; Spleen; Disposition; Spectroscopy; Titanium dioxide; Phosphate; Lung; Energy; Ionizing radiation; Kidney; nanoparticles; Sodium chloride; Phosphates; titanium dioxide; Microscopy; Brain; X-ray spectroscopy; Mice; Particulates DO - http://dx.doi.org/10.1002/jat.1454 ER - TY - JOUR T1 - Combining complex signal change in functional MRI AN - 883018746; 15255271 AB - No abstract is available for this article. JF - Magnetic Resonance in Medicine AU - Lee, Jongho AU - Shahram, Morteza AU - Pauly, John M AD - Advanced MRI, Laboratory for Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, jonghoyi@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1358 EP - 1360 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 5 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Functional magnetic resonance imaging KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883018746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Combining+complex+signal+change+in+functional+MRI&rft.au=Lee%2C+Jongho%3BShahram%2C+Morteza%3BPauly%2C+John+M&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2009-11-01&rft.volume=62&rft.issue=5&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22104 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22104/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; N.M.R. DO - http://dx.doi.org/10.1002/mrm.22104 ER - TY - JOUR T1 - Sensitivity and specificity of univariate MRI analysis of experimentally degraded cartilage AN - 883014940; 15255264 AB - MRI is increasingly used to evaluate cartilage in tissue constructs, explants, and animal and patient studies. However, while mean values of MR parameters, including T1, T2, magnetization transfer rate km, apparent diffusion coefficient (ADC), and the dGEMRIC-derived fixed charge density, correlate with tissue status, the ability to classify tissue according to these parameters has not been explored. Therefore, the sensitivity and specificity with which each of these parameters was able to distinguish between normal and trypsin-degraded, and between normal and collagenase-degraded, cartilage explants were determined. Initial analysis was performed using a training set to determine simple group means to which parameters obtained from a validation set were compared. T1 and apparent diffusion coefficient showed the greatest ability to discriminate between normal and degraded cartilage. Further analysis with k-means clustering, which eliminates the need for a priori identification of sample status, generally performed comparably. Use of fuzzy c-means (FCM) clustering to define centroids likewise did not result in improvement in discrimination. Finally, an FCM clustering approach in which validation samples were assigned in a probabilistic fashion to control and degraded groups was implemented, reflecting the range of tissue characteristics seen with cartilage degradation. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Lin, Ping-Chang AU - Reiter, David A AU - Spencer, Richard G Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1311 EP - 1318 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 5 SN - 1522-2594, 1522-2594 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Cartilage KW - Collagen KW - Diffusion coefficient KW - Explants KW - Magnetic resonance imaging KW - N.M.R. KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883014940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Sensitivity+and+specificity+of+univariate+MRI+analysis+of+experimentally+degraded+cartilage&rft.au=Lin%2C+Ping-Chang%3BReiter%2C+David+A%3BSpencer%2C+Richard+G&rft.aulast=Lin&rft.aufirst=Ping-Chang&rft.date=2009-11-01&rft.volume=62&rft.issue=5&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22110 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22110/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Cartilage; Magnetic resonance imaging; N.M.R.; Diffusion coefficient; Explants; Collagen DO - http://dx.doi.org/10.1002/mrm.22110 ER - TY - JOUR T1 - Nanoparticles in sentinel lymph node mapping AN - 869590290; 14821124 AB - The lymph nodes and lymphatic vessels are more difficult to access than most vascular structures. Interstitial injection of imaging agents is often necessary to opacify the lymphatics. Traditionally, radionuclide methods of sentinel node imaging have dominated this field, however, limitations in resolution and exposure to radiation have encouraged the development of newer imaging methods. Among these are magnetic resonance lymphography in which a Gadolinium labeled nanoparticle is injected and imaged providing superior anatomic resolution and assessment of lymphatic dynamics. Optical imaging employing various nanoparticles including quantum dots also provide the capability of mapping each lymphatic basin in another 'color'. Taken together this 'toolbox' of lymphatic imaging agents is poised to improve our understanding of the lymphatic system. JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Ravizzini, Gregory AU - Turkbey, Baris AU - Barrett, Tristan AU - Kobayashi, Hisataka AU - Choyke, Peter L AD - Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, pchoyke@nih.gov Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 610 EP - 623 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 1 IS - 6 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Gadolinium KW - Basins KW - Lymph nodes KW - Color KW - Radiation KW - Quantum dots KW - Computed tomography KW - Radioisotopes KW - Lymphography KW - N.M.R. KW - Mapping KW - nanoparticles KW - Lymphatic system KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869590290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Nanoparticles+in+sentinel+lymph+node+mapping&rft.au=Ravizzini%2C+Gregory%3BTurkbey%2C+Baris%3BBarrett%2C+Tristan%3BKobayashi%2C+Hisataka%3BChoyke%2C+Peter+L&rft.aulast=Ravizzini&rft.aufirst=Gregory&rft.date=2009-11-01&rft.volume=1&rft.issue=6&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.48 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Gadolinium; Basins; Lymph nodes; Color; Radiation; Quantum dots; Computed tomography; Radioisotopes; Lymphography; N.M.R.; Mapping; nanoparticles; Lymphatic system; nanotechnology DO - http://dx.doi.org/10.1002/wnan.48 ER - TY - JOUR T1 - Dynamics of emotion regulation in infants of clinically depressed and nondepressed mothers AN - 839573735; 201102666 AB - Background: Emotion regulation (ER) has been conceptualized as an ongoing process of the individual's emotion patterns in relation to moment-to-moment contextual demands. In contrast to traditional approaches of descriptively quantizing ER, we employed a dynamic approach to ER by examining key transitions in infants of clinically depressed and nondepressed mothers in the context of maternal still-face (SF). Methods: Mothers with (n=48) and without a clinical diagnosis of depression (n =68) were seen in a modified SF paradigm with their 5-month-olds. Infant states and self-soothing behaviors were coded in 1-sec time intervals. Results: Infants of nondepressed mothers used attentional regulatory strategies, whereas infants of depressed mothers used internally directed strategies of self-soothing to reduce negativity and maintain engagement with mother. Conclusions: This study advances our understanding of processes underlying infant ER and points to possible mechanisms for the development of long-term maladaptive ER strategies in infants of depressed mothers. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Manian, Nanmathi AU - Bornstein, Marc H AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health maniann@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1410 EP - 1418 PB - Blackwell Publishing, Oxford UK VL - 50 IS - 11 SN - 0021-9630, 0021-9630 KW - Emotion regulation maternal depression mother-infant interaction still-face paradigm sequential analysis KW - Emotions KW - Depression KW - Diagnosis KW - Mothers KW - Emotional regulation KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839573735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Dynamics+of+emotion+regulation+in+infants+of+clinically+depressed+and+nondepressed+mothers&rft.au=Manian%2C+Nanmathi%3BBornstein%2C+Marc+H&rft.aulast=Manian&rft.aufirst=Nanmathi&rft.date=2009-11-01&rft.volume=50&rft.issue=11&rft.spage=1410&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2009.02166.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Infants; Mothers; Emotional regulation; Diagnosis; Emotions; Depression DO - http://dx.doi.org/10.1111/j.1469-7610.2009.02166.x ER - TY - JOUR T1 - Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--A prospective cohort study AN - 746299247; 13008936 AB - Background: Pancreatic cancer is a highly fatal disease without screening tests. Studies have suggested possible etiologic similarities between gastric and pancreatic cancers. Atrophic gastritis, a pre-malignant condition for gastric cancer, is characterized by low serum pepsinogen I (SPGI) level. We hypothesized that low SPGI level may be associated with an increased risk of pancreatic cancer and be a useful biomarker for the disease. Methods: Our analytic cohort included 20,962 participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) who had SPGI level measured. Of these, 1663 (7.9%) subjects had low SPGI levels (<25I14g/l) and were invited for gastroscopy which was completed in 1059 (63.7%) participants. Atrophic gastritis was histologically confirmed in 1006 (95.0%) subjects. We used Cox proportional hazards regression to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for pancreatic cancer. Results: During follow-up of up to 16.3 years (mean=10.8 years; 226,325 person-years), 227 incident pancreatic cancers were diagnosed. The incidence rates were 9.9, 11.3, and 12.7 per 10,000 person-years of follow-up for participants with normal pepsinogen level (a[control][yen25I14g/l), low pepsinogen level and histologically confirmed atrophic gastritis, respectively. Compared to subjects with normal pepsinogen levels, there was no statistically significant increased risk of pancreatic cancer among subjects with low pepsinogen level (adjusted HR=1.01; 95% CI: 0.63-1.62) or those with histologically confirmed atrophic gastritis (adjusted HR=1.13; 95% CI: 0.66-1.95). Conclusions: Atrophic gastritis, serological or histological, is not associated with increased risk of pancreatic cancer. These findings do not provide any evidence for potential usefulness of SPGI for pancreatic cancer screening. JF - Cancer Epidemiology AU - Laiyemo, Adeyinka O AU - Kamangar, Farin AU - Marcus, Pamela M AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael Z AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, United States Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 368 EP - 373 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 5 SN - 1877-7821, 1877-7821 KW - Risk Abstracts KW - Bioindicators KW - pancreatic cancer KW - prevention KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746299247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology&rft.atitle=Serum+pepsinogen+level%2C+atrophic+gastritis+and+the+risk+of+incident+pancreatic+cancer--A+prospective+cohort+study&rft.au=Laiyemo%2C+Adeyinka+O%3BKamangar%2C+Farin%3BMarcus%2C+Pamela+M%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Laiyemo&rft.aufirst=Adeyinka&rft.date=2009-11-01&rft.volume=33&rft.issue=5&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology&rft.issn=18777821&rft_id=info:doi/10.1016%2Fj.canep.2009.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Bioindicators; pancreatic cancer; prevention; Cancer DO - http://dx.doi.org/10.1016/j.canep.2009.09.001 ER - TY - JOUR T1 - Age-specific physical activity and prostate cancer risk among white men and black men AN - 745631266; 12746082 AB - BACKGROUND: The relation of physical activity across the lifespan to risk of prostate cancer has not been thoroughly investigated, particularly among black men. The authors investigated physical activity, including activity during different age periods and of various intensities, in relation to prostate cancer incidence among white men and black men. METHODS: In total, 160,006 white men and 3671 black men ages 51 years to 72 years who were enrolled in the National Institutes of Health-AARP Diet and Health Study reported their time spent per week engaging in physical activity during ages 15 to 18 years, 19 years to 29 years, 35 years to 39 years, and during the past 10 years. Cox regression models were used to examine physical activity, categorized by intensity (moderate or vigorous, light, and total), in relation to prostate cancer risk. RESULTS: During 7 years of follow-up, 9624 white men and 371 black men developed prostate cancer. Among white men, physical activity had no association with prostate cancer regardless of age period or activity intensity. Among black men, engaging in 4 hours of moderate/vigorous intensity physical activity versus infrequent activity during ages 19 years to 29 years was related to a 35% lower risk of prostate cancer (relative risk, 0.65; 95% confidence interval [95% CI], 0.43-0.99 [Ptrend = .01]). Frequent moderate/vigorous physical activity at ages 35 years to 39 years also potentially was related to reduced prostate cancer risk (relative risk, 0.59; 95% CI, 0.36-0.96 [Ptrend = .15]). CONCLUSIONS: Regular physical activity may reduce prostate cancer risk among black men, and activity during young adulthood may yield the greatest benefit. This novel finding needs confirmation in additional studies. Cancer 2009. Published 2009 by the American Cancer Society. JF - Cancer AU - Moore, Steven C AU - Peters, Tricia M AU - Ahn, Jiyoung AU - Park, Yikyung AU - Schatzkin, Arthur AU - Albanes, Demetrius AU - Hollenbeck, Albert AU - Leitzmann, Michael F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, moorest@mail.nih.gov Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 5060 EP - 5070 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 115 IS - 21 SN - 0008-543X, 0008-543X KW - Physical Education Index; Risk Abstracts KW - Diets KW - Age KW - Men KW - Blacks KW - males KW - Health KW - Exercise KW - Cancer KW - Diet KW - physical activity KW - prostate cancer KW - Youth KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745631266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Age-specific+physical+activity+and+prostate+cancer+risk+among+white+men+and+black+men&rft.au=Moore%2C+Steven+C%3BPeters%2C+Tricia+M%3BAhn%2C+Jiyoung%3BPark%2C+Yikyung%3BSchatzkin%2C+Arthur%3BAlbanes%2C+Demetrius%3BHollenbeck%2C+Albert%3BLeitzmann%2C+Michael+F&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2009-11-01&rft.volume=115&rft.issue=21&rft.spage=5060&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24538 L2 - http://www3.interscience.wiley.com/journal/122527380/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blacks; Men; Health; Diet; Exercise; Youth; Cancer; Diets; Age; males; prostate cancer; physical activity DO - http://dx.doi.org/10.1002/cncr.24538 ER - TY - JOUR T1 - Otolaryngologic markers for the early diagnosis of Turner syndrome. AN - 742786782; pmid-19732968 AB - OBJECTIVE: To identify and characterize otolaryngologic markers for the early diagnosis of Turner syndrome (TS). STUDY DESIGN: Prospective cohort survey. METHODS: Setting: Clinical Center of the National Institutes of Health (NIH). Patients: Ninety-one females, 7-61 years old (average=28.7 y), enrolled in a multidisciplinary study of karyotype-phenotype correlations in TS. Main outcome measures: Age at diagnosis, X chromosome karyotype, history of chronic or recurrent otitis media (OM), sensorineural hearing loss (SNHL), palate dysmorphism, pinna deformity, pterygium colli, low posterior hairline, low-set ears, and micrognathia. RESULTS: Sixty-nine (76%) patients had a history of chronic or recurrent OM, 62 (68%) had a dysmorphic palate, 57 (63%) had SNHL, and 90 (99%) had one or more of these findings. 83 (91%; average age at diagnosis=9.4 y) had one or more external craniofacial signs: pinna abnormalities, pterygium colli, low-set ears, micrognathia or a low posterior hairline. Eight patients (average age at diagnosis=13.2 y) had no external craniofacial signs, although seven (88%) of these eight patients had a history of chronic or recurrent OM, dysmorphic palate or SNHL. The age at diagnosis was not significantly different between groups with or without external craniofacial signs (P=0.126). CONCLUSIONS: Patients with mild or incompletely penetrant TS phenotypes often present with otitis media, hearing loss, or both before the diagnosis of TS is established. Palatal dysmorphism, including ogival morphology, is another otolaryngologic marker for TS. Prompt recognition of these manifestations of TS could hasten its diagnosis and appropriate medical care. JF - International journal of pediatric otorhinolaryngology AU - Makishima, Tomoko AU - King, Kelly AU - Brewer, Carmen C AU - Zalewski, Christopher K AU - Butman, John AU - Bakalov, Vladimir K AU - Bondy, Carolyn AU - Griffith, Andrew J AD - Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850-3320, USA. Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1564 EP - 1567 VL - 73 IS - 11 SN - 0165-5876, 0165-5876 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Turner Syndrome -- complications KW - Humans KW - Palate -- abnormalities KW - Child KW - Turner Syndrome -- genetics KW - Mouth Diseases -- congenital KW - Turner Syndrome -- diagnosis KW - Prospective Studies KW - Adult KW - Middle Aged KW - Adolescent KW - Mouth Diseases -- genetics KW - Early Diagnosis KW - Female KW - Otitis Media -- genetics KW - Hearing Loss -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742786782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pediatric+otorhinolaryngology&rft.atitle=Otolaryngologic+markers+for+the+early+diagnosis+of+Turner+syndrome.&rft.au=Makishima%2C+Tomoko%3BKing%2C+Kelly%3BBrewer%2C+Carmen+C%3BZalewski%2C+Christopher+K%3BButman%2C+John%3BBakalov%2C+Vladimir+K%3BBondy%2C+Carolyn%3BGriffith%2C+Andrew+J&rft.aulast=Makishima&rft.aufirst=Tomoko&rft.date=2009-11-01&rft.volume=73&rft.issue=11&rft.spage=1564&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pediatric+otorhinolaryngology&rft.issn=01655876&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Implications and conclusions--vascular cognitive impairment: evolution of the concept. AN - 742785385; pmid-19891822 JF - Journal of the International Neuropsychological Society : JINS AU - Merino, José G AU - Hachinski, Vladimir AD - Stroke Program, Suburban Hospital, Bethesda, Maryland 20814, USA. merinoj@ninds.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 924 EP - 926 VL - 15 IS - 6 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Disease Progression KW - Neuropsychological Tests KW - Vascular Diseases -- complications KW - Cognition Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742785385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Implications+and+conclusions--vascular+cognitive+impairment%3A+evolution+of+the+concept.&rft.au=Merino%2C+Jos%C3%A9+G%3BHachinski%2C+Vladimir&rft.aulast=Merino&rft.aufirst=Jos%C3%A9&rft.date=2009-11-01&rft.volume=15&rft.issue=6&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Autologous freeze-treated bone for mandibular reconstruction after malignant tumor resection: a study of 72 patients. AN - 742781412; pmid-19880026 AB - OBJECTIVE: The aim of the study was to assess the possibility of mandibular reconstruction with autologous freeze-treated bone after mandibular resection for malignant tumors. PATIENTS: The medical records of 72 consecutive patients surgically treated with segmental mandibular resection and reconstruction with autologous freeze-treated mandible were reviewed. RESULTS: All tumors were in stage T4a for deep infiltration of the mandible. Soft tissues were reconstructed with a direct mucosal closure (4 cases), with a pedicled pectoralis flap (17 cases), and with a forearm fasciocutaneous free flap without or with radial periosteum (18 and 33 cases). Four patients presented with a recurrence after previous surgery and radiotherapy, and 26 patients underwent postoperative radiotherapy. We resected the mental arch in 35 cases and the lateral mandible in 37 cases. Forty-one patients (56.9%) retained their autologous mandibular graft. In 31 cases, the bone graft was removed for mucosal dehiscence and bone infection. Lateral resections achieved a better success rate than anterior resections (75.7% vs 37.1%). The pedicled pectoralis flap achieved the worse success rate (35.3%) in comparison with forearm fasciocutaneous flap (66.7%). Postoperative radiotherapy decreased the success rate (40.0% vs 69.1%). CONCLUSIONS: Mandibular reconstruction with autologous frozen bone is an interesting alternative to more sophisticated methods for patients with oral cancer involving the bone. It is time and cost sparing in comparison to fibula or iliac crest flaps. However, in spite of any intraoral reconstruction, the success rate is not stirring. In our opinion, this type of mandibular reconstruction must be reserved to patients with lateral tumors, with poor prognosis, or severe comorbidities not allowing more complex bone reconstruction. JF - American journal of otolaryngology AU - Cantu, Giulio AU - Bimbi, Gabriella AU - Colombo, Sarah AU - Riccio, Stefano AU - Squadrelli, Massimo AU - Napoli, Umberto AU - Pompilio, Madia AD - Department of Cranio-Maxillo-Facial Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano (National Cancer Institute), Milano, Italy. giulio.cantu@istitutotumori.mi.it Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 383 EP - 389 VL - 30 IS - 6 SN - 0196-0709, 0196-0709 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Bone Transplantation -- methods KW - Neoplasm Recurrence, Local -- epidemiology KW - Humans KW - Postoperative Complications -- prevention & control KW - Retrospective Studies KW - Aged KW - Child KW - Surgical Flaps KW - Carcinoma, Squamous Cell -- pathology KW - Adult KW - Treatment Outcome KW - Surgical Wound Infection -- prevention & control KW - Surgical Wound Infection -- epidemiology KW - Adolescent KW - Male KW - Surgical Wound Dehiscence -- prevention & control KW - Neoplasm Staging KW - Combined Modality Therapy KW - Freezing KW - Transplantation, Autologous KW - Neoplasm Recurrence, Local -- prevention & control KW - Child, Preschool KW - Carcinoma, Squamous Cell -- surgery KW - Mandibular Neoplasms -- radiotherapy KW - Mandibular Neoplasms -- pathology KW - Surgical Wound Dehiscence -- epidemiology KW - Postoperative Complications -- epidemiology KW - Middle Aged KW - Mandibular Neoplasms -- surgery KW - Reconstructive Surgical Procedures KW - Carcinoma, Squamous Cell -- radiotherapy KW - Female KW - Mandible -- transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+otolaryngology&rft.atitle=Autologous+freeze-treated+bone+for+mandibular+reconstruction+after+malignant+tumor+resection%3A+a+study+of+72+patients.&rft.au=Cantu%2C+Giulio%3BBimbi%2C+Gabriella%3BColombo%2C+Sarah%3BRiccio%2C+Stefano%3BSquadrelli%2C+Massimo%3BNapoli%2C+Umberto%3BPompilio%2C+Madia&rft.aulast=Cantu&rft.aufirst=Giulio&rft.date=2009-11-01&rft.volume=30&rft.issue=6&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=American+journal+of+otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain. AN - 734134554; 19674120 AB - Fear extinction is impaired in psychiatric disorders such as post-traumatic stress disorder and schizophrenia, which have a major genetic component. However, the genetic factors underlying individual variability in fear extinction remain to be determined. By comparing a panel of inbred mouse strains, we recently identified a strain, 129S1/SvImJ (129S1), that exhibits a profound and selective deficit in Pavlovian fear extinction, and associated abnormalities in functional activation of a key prefrontal-amygdala circuit, as compared with C57BL/6J. The first aim of the present study was to assess fear extinction across multiple 129 substrains representing the strain's four different genetic lineages (parental, steel, teratoma and contaminated). Results showed that 129P1/ReJ, 129P3/J, 129T2/SvEmsJ and 129X1/SvJ exhibited poor fear extinction, relative to C57BL/6J, while 129S1 showed evidence of fear incubation. On the basis of these results, the second aim was to further characterize the nature and specificity of the extinction phenotype in 129S1, as an exemplar of the 129 substrains. Results showed that the extinction deficit in 129S1 was neither the result of a failure to habituate to a sensitized fear response nor an artifact of a fear response to (unconditioned) tone per se. A stronger conditioning protocol (i.e. five x higher intensity shocks) produced an increase in fear expression in 129S1, relative to C57BL/6J, due to rapid rise in freezing during tone presentation. Taken together, these data show that impaired fear extinction is a phenotypic feature common across 129 substrains, and provide preliminary evidence that impaired fear extinction in 129S1 may reflect a pro-fear incubation-like process. JF - Genes, brain, and behavior AU - Camp, M AU - Norcross, M AU - Whittle, N AU - Feyder, M AU - D'Hanis, W AU - Yilmazer-Hanke, D AU - Singewald, N AU - Holmes, A AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, USA. campmc@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 744 EP - 752 VL - 8 IS - 8 KW - Index Medicus KW - Phenotype KW - Mice, Inbred Strains KW - Animals KW - Avoidance Learning -- physiology KW - Brain Chemistry -- genetics KW - Mice, Inbred C57BL KW - Mice KW - Acoustic Stimulation KW - Neuropsychological Tests KW - Species Specificity KW - Male KW - Genome -- genetics KW - Conditioning (Psychology) -- physiology KW - Genetic Variation -- genetics KW - Extinction, Psychological -- physiology KW - Fear -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734134554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+brain%2C+and+behavior&rft.atitle=Impaired+Pavlovian+fear+extinction+is+a+common+phenotype+across+genetic+lineages+of+the+129+inbred+mouse+strain.&rft.au=Camp%2C+M%3BNorcross%2C+M%3BWhittle%2C+N%3BFeyder%2C+M%3BD%27Hanis%2C+W%3BYilmazer-Hanke%2C+D%3BSingewald%2C+N%3BHolmes%2C+A&rft.aulast=Camp&rft.aufirst=M&rft.date=2009-11-01&rft.volume=8&rft.issue=8&rft.spage=744&rft.isbn=&rft.btitle=&rft.title=Genes%2C+brain%2C+and+behavior&rft.issn=1601-183X&rft_id=info:doi/10.1111%2Fj.1601-183X.2009.00519.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-10 N1 - Date created - 2009-11-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2004 Aug;20(3):781-90 [15255988] Behav Brain Res. 2005 Feb 28;157(2):291-8 [15639180] Behav Res Ther. 1968 Aug;6(3):309-21 [5734549] Nature. 1981 Jul 9;292(5819):154-6 [7242681] Brain Res. 1982 May 13;239(2):329-47 [7093694] Psychopharmacology (Berl). 1997 Jul;132(2):107-24 [9266608] Neuroscience. 1997 Oct;80(4):1087-99 [9284062] Brain Res. 1997 Oct 10;771(1):1-13 [9383002] Pharmacol Biochem Behav. 2005 Mar;80(3):427-36 [15740785] Nat Genet. 2005 May;37(5):532-6 [15852006] Hippocampus. 2005;15(4):502-17 [15744733] Learn Mem. 2005 Jul-Aug;12(4):399-406 [16077018] Nat Rev Drug Discov. 2005 Sep;4(9):775-90 [16138108] Comp Med. 2005 Aug;55(4):326-34 [16158908] Nat Genet. 2005 Nov;37(11):1175-80 [16254563] Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3693-7 [16484369] J Neurosci. 2006 Jun 21;26(25):6677-86 [16793875] Learn Mem. 2006 Nov-Dec;13(6):728-33 [17142302] Behav Brain Res. 2007 Jan 25;176(2):210-5 [17098297] Mol Psychiatry. 2007 Feb;12(2):120-50 [17160066] Neuropsychopharmacology. 2008 Jan;33(1):56-72 [17882236] J Neurosci. 2008 Aug 6;28(32):8074-85 [18685032] Psychopharmacology (Berl). 2008 Oct;200(3):413-24 [18594797] J Neurosci. 2008 Nov 19;28(47):12147-9 [19020008] Genes Brain Behav. 2009 Feb;8(1):1-4 [18778401] Biol Psychiatry. 2009 Mar 15;65(6):455-63 [18986648] Neurosci Biobehav Rev. 2009 Jun;33(6):773-83 [19111570] Biol Psychiatry. 2009 May 15;65(10):881-6 [19167702] Trends Neurosci. 2002 Jul;25(7):336-40 [12079755] Learn Mem. 2000 May-Jun;7(3):170-9 [10837506] Mamm Genome. 2001 Aug;12(8):651-6 [11471061] Arch Gen Psychiatry. 2001 Nov;58(11):1005-14 [11695946] Behav Neurosci. 2002 Aug;116(4):600-11 [12148927] J Gen Psychol. 2002 Oct;129(4):364-400 [12494990] Behav Brain Res. 2003 Mar 18;140(1-2):97-106 [12644283] Cell. 1987 Nov 6;51(3):503-12 [2822260] Nat Genet. 1997 May;16(1):19-27 [9140391] Mamm Genome. 1997 Jun;8(6):390-3 [9166580] Genes Brain Behav. 2002 Jan;1(1):55-69 [12886950] J Exp Psychol Anim Behav Process. 2003 Oct;29(4):323-33 [14570519] Genes Brain Behav. 2004 Jun;3(3):149-57 [15140010] Mamm Genome. 1999 Aug;10(8):836 [10430671] Learn Mem. 2004 Nov-Dec;11(6):770-86 [15537742] J Comp Physiol Psychol. 1969 Mar;67(3):370-5 [5787388] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1601-183X.2009.00519.x ER - TY - JOUR T1 - Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers. AN - 734128419; 19892664 AB - Nonsteroidal anti-inflammatory drugs (NSAID) have been highly effective in preventing colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon adenoma formation. However, certain NSAIDs cause gastrointestinal ulceration and may increase cardiovascular events. Naproxen seems to cause the lowest cardiovascular events of the common NSAIDs other than aspirin. Nitric oxide (NO)-naproxen was tested based on the finding that adding a NO group to NSAIDs may help alleviate GI toxicity. In the azoxymethane-induced rat colon aberrant crypt foci (ACF) model, naproxen administered at 200 and 400 ppm in the diet reduced mean ACFs in the colon by about 45% to 60%, respectively. NO-naproxen was likewise administered in the diet at roughly equimolar doses (300 and 600 ppm) and reduced total ACF by 20% to 40%, respectively. In the hydroxybutyl (butyl) nitrosamine rat urinary bladder cancer model, NO-naproxen was given at 183 or 550 ppm in the diet, and naproxen at 128 ppm. The NO-naproxen groups had 77% and 73% decreases, respectively, in the development of large urinary bladder tumors, whereas the 128 ppm naproxen group also showed a strong decrease (69%). If treatments were started 3 months after hydroxybutyl (butyl) nitrosamine, NO-naproxen (550 ppm) and naproxen (400 ppm) were also highly effective (86-94% decreases). In the methylnitrosourea-induced mammary cancer model in rats, NO-naproxen and naproxen showed nonsignificant inhibitions (12% and 24%) at 550 and 400 ppm, respectively. These data show that both naproxen and NO-naproxen are effective agents against urinary bladder and colon, but not mammary, carcinogenesis. JF - Cancer prevention research (Philadelphia, Pa.) AU - Steele, Vernon E AU - Rao, Chinthalapally V AU - Zhang, Yuting AU - Patlolla, Jagan AU - Boring, Daniel AU - Kopelovich, Levy AU - Juliana, M Margaret AU - Grubbs, Clinton J AU - Lubet, Ronald A AD - Chemopreventive Agent Development Research Group, Division of Cancer Prevention, NIH, Bethesda, Maryland, USA. Steelev@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 951 EP - 956 VL - 2 IS - 11 KW - Alkylating Agents KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Carcinogens KW - Nitric Oxide Donors KW - naproxen-n-butyl nitrate KW - Butylhydroxybutylnitrosamine KW - 3817-11-6 KW - Naproxen KW - 57Y76R9ATQ KW - Methylnitrosourea KW - 684-93-5 KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Butylhydroxybutylnitrosamine -- toxicity KW - Azoxymethane -- toxicity KW - Carcinogens -- toxicity KW - Methylnitrosourea -- toxicity KW - Precancerous Conditions -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Precancerous Conditions -- chemically induced KW - Precancerous Conditions -- prevention & control KW - Alkylating Agents -- toxicity KW - Diet KW - Female KW - Male KW - Mammary Neoplasms, Experimental -- chemically induced KW - Urinary Bladder Neoplasms -- prevention & control KW - Naproxen -- therapeutic use KW - Naproxen -- analogs & derivatives KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Nitric Oxide Donors -- therapeutic use KW - Colonic Neoplasms -- metabolism KW - Mammary Neoplasms, Experimental -- prevention & control KW - Mammary Neoplasms, Experimental -- metabolism KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced KW - Urinary Bladder Neoplasms -- metabolism KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734128419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Chemopreventive+efficacy+of+naproxen+and+nitric+oxide-naproxen+in+rodent+models+of+colon%2C+urinary+bladder%2C+and+mammary+cancers.&rft.au=Steele%2C+Vernon+E%3BRao%2C+Chinthalapally+V%3BZhang%2C+Yuting%3BPatlolla%2C+Jagan%3BBoring%2C+Daniel%3BKopelovich%2C+Levy%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J%3BLubet%2C+Ronald+A&rft.aulast=Steele&rft.aufirst=Vernon&rft.date=2009-11-01&rft.volume=2&rft.issue=11&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-09-0080 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-12 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1988 Nov 1;48(21):6187-92 [3167865] Trends Mol Med. 2004 Jul;10(7):324-30 [15242680] J Cell Biochem Suppl. 1992;16G:55-62 [1361589] Biometrics. 1993 Mar;49(1):259-68 [8513108] Carcinogenesis. 1993 Aug;14(8):1493-7 [8353834] Cancer Res. 1993 Sep 15;53(18):4182-8 [8364913] Cancer Res. 1995 Apr 1;55(7):1464-72 [7882354] Cancer Lett. 1995 Jun 29;93(1):55-71 [7600544] Cancer Epidemiol Biomarkers Prev. 1996 May;5(5):355-60 [9162301] Mol Carcinog. 1999 Aug;25(4):231-40 [10449029] Ann Rheum Dis. 2005 Mar;64(3):449-56 [15345500] N Engl J Med. 2005 Mar 17;352(11):1071-80 [15713944] Scand J Gastroenterol. 2006 Mar;41(3):264-73 [16497612] Carcinogenesis. 2006 Jun;27(6):1232-9 [16344269] Carcinogenesis. 2006 Jun;27(6):1214-21 [16352617] BMJ. 2006 Jun 3;332(7553):1302-8 [16740558] Mol Cancer Ther. 2006 Jun;5(6):1530-8 [16818512] N Engl J Med. 2006 Aug 31;355(9):873-84 [16943400] JAMA. 2006 Oct 4;296(13):1619-32 [16968832] Mol Cancer Ther. 2007 Jul;6(7):2022-8 [17620432] Am J Clin Dermatol. 2007;8(4):195-200 [17645375] Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5488-96 [17875779] Acta Pharmacol Sin. 2008 Jan;29(1):1-20 [18158862] Am J Gastroenterol. 2008 Nov;103(11):2908-18 [18853980] Clin Pharmacol Ther. 2009 Feb;85(2):190-7 [18987620] Trends Pharmacol Sci. 2009 Mar;30(3):112-7 [19230986] Cancer Res. 2000 Jan 15;60(2):293-7 [10667579] Cancer Res. 2000 Oct 15;60(20):5599-602 [11059745] Mutat Res. 2003 Feb-Mar;523-524:137-44 [12628511] Curr Cancer Drug Targets. 2004 Feb;4(1):29-42 [14965265] Semin Oncol. 2004 Apr;31(2 Suppl 7):36-44 [15179622] Cancer Res. 1991 Oct 1;51(19):5270-4 [1913650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-09-0080 ER - TY - JOUR T1 - A clinical algorithm identifies high risk pediatric oncology and bone marrow transplant patients likely to benefit from treatment of adenoviral infection. AN - 734127644; 19801951 AB - Adenoviral infections cause morbidity and mortality in blood and marrow transplantation and pediatric oncology patients. Cidofovir is active against adenovirus, but must be used judiciously because of its nephrotoxicity and unclear indications. Therefore, before introducing cidofovir use during an adenoviral outbreak, we developed a clinical algorithm to distinguish low risk patients from those who merited cidofovir therapy because of significant adenoviral disease and high risk for death. This study was conducted to determine whether the algorithm accurately predicted severe adenovirus disease and whether selective cidofovir treatment was beneficial. A retrospective analysis of a pediatric oncology/blood and marrow transplantation cohort prealgorithm and postalgorithm implementation was performed. Twenty patients with adenovirus infection were identified (14 high risk and 6 low risk). All low-risk patients cleared their infections without treatment. Before algorithm implementation, all untreated high-risk patients died, 4 out of 5 (80%), from adenoviral infection. In contrast, cidofovir reduced adenovirus-related mortality in the high-risk group postalgorithm implementation (9 patients treated, 1 patient died; RR 0.14, P<0.05) and all treated high-risk patients cleared their virus. The clinical algorithm accurately identified patients at high risk for severe fatal adenoviral disease who would benefit from selective use of cidofovir. JF - Journal of pediatric hematology/oncology AU - Williams, Kirsten Marie AU - Agwu, Allison L AU - Dabb, Alix A AU - Higman, Meghan A AU - Loeb, David M AU - Valsamakis, Alexandra AU - Chen, Allen R AD - Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. williaki@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 825 EP - 831 VL - 31 IS - 11 KW - Antiviral Agents KW - 0 KW - Organophosphonates KW - Cytosine KW - 8J337D1HZY KW - cidofovir KW - JIL713Q00N KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Child KW - Transplantation, Homologous KW - Transplantation, Autologous KW - Male KW - Female KW - Child, Preschool KW - Antiviral Agents -- administration & dosage KW - Algorithms KW - Adenoviridae Infections -- mortality KW - Adenoviridae Infections -- diagnosis KW - Cytosine -- administration & dosage KW - Organophosphonates -- administration & dosage KW - Adenoviridae Infections -- drug therapy KW - Cytosine -- analogs & derivatives KW - Bone Marrow Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734127644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+hematology%2Foncology&rft.atitle=A+clinical+algorithm+identifies+high+risk+pediatric+oncology+and+bone+marrow+transplant+patients+likely+to+benefit+from+treatment+of+adenoviral+infection.&rft.au=Williams%2C+Kirsten+Marie%3BAgwu%2C+Allison+L%3BDabb%2C+Alix+A%3BHigman%2C+Meghan+A%3BLoeb%2C+David+M%3BValsamakis%2C+Alexandra%3BChen%2C+Allen+R&rft.aulast=Williams&rft.aufirst=Kirsten&rft.date=2009-11-01&rft.volume=31&rft.issue=11&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+hematology%2Foncology&rft.issn=1536-3678&rft_id=info:doi/10.1097%2FMPH.0b013e3181b7873e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-08 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2000 Feb;25(3):277-82 [10673699] Pediatr Transplant. 2008 Mar;12(2):219-27 [18307672] Pediatr Infect Dis J. 2000 Nov;19(11):1097-100 [11099095] J Clin Microbiol. 2001 Feb;39(2):498-505 [11158096] Bone Marrow Transplant. 2000 Dec;26(12):1333-8 [11223974] Clin Infect Dis. 2001 Mar 15;32(6):871-6 [11247710] Bone Marrow Transplant. 2001 Mar;27(6):621-6 [11319592] Pediatr Hematol Oncol. 2002 Jul-Aug;19(5):361-71 [12078868] Pediatrics. 2002 Jul;110(1 Pt 1):e9 [12093990] Bone Marrow Transplant. 2003 Apr;31(8):695-700 [12692610] Arch Pathol Lab Med. 2003 May;127(5):e246-8 [12708923] Blood. 2003 Aug 1;102(3):1114-20 [12702513] Bone Marrow Transplant. 2003 Dec;32(11):1107-8 [14625585] Trends Mol Med. 2004 May;10(5):226-31 [15121049] Clin Infect Dis. 2004 Jun 1;38(11):1521-5 [15156436] Eur J Clin Microbiol Infect Dis. 2004 Aug;23(8):583-8 [15248091] J Clin Microbiol. 1999 Mar;37(3):686-9 [9986832] Bone Marrow Transplant. 1999 Feb;23(3):277-82 [10084260] Bone Marrow Transplant. 2004 Nov;34(10):909-14 [15361907] Am J Transplant. 2004 Dec;4(12):2102-8 [15575915] J Infect Dis. 2005 Feb 15;191(4):520-30 [15655775] J Pediatr Hematol Oncol. 2005 Feb;27(2):67-72 [15701979] Bone Marrow Transplant. 2005 Mar;35 Suppl 1:S73-6 [15812536] J Clin Microbiol. 2005 Apr;43(4):1738-44 [15814994] Clin Infect Dis. 2005 May 1;40(9):1244-9 [15825025] Br J Haematol. 2005 Aug;130(4):595-603 [16098075] J Virol. 2005 Nov;79(22):14429-36 [16254377] Biol Blood Marrow Transplant. 2005 Nov;11(11):912-20 [16275594] Clin Infect Dis. 2005 Dec 15;41(12):1812-6 [16288409] Transplantation. 2006 May 27;81(10):1398-404 [16732176] Biol Blood Marrow Transplant. 2007 Jan;13(1):74-81 [17222755] J Pediatr Hematol Oncol. 2007 Feb;29(2):81-5 [17279003] Semin Immunol. 2007 Oct;19(5):318-30 [18023361] Bone Marrow Transplant. 2000 Aug;26(3):305-7 [10967570] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MPH.0b013e3181b7873e ER - TY - JOUR T1 - Null retinoschisin-protein expression from an RS1 c354del1-ins18 mutation causing progressive and severe XLRS in a cross-sectional family study. AN - 734121474; 19474399 AB - To explore the retinoschisin (RS1) protein biochemical phenotype from an RS1 exon-5 deletion/insertion frame-shift mutation in a family with X-linked retinoschisis (XLRS) and describe the clinical and electrophysiological features. Six XLRS males underwent ophthalmic examination and electroretinogram (ERG) recording. The RS1 gene was sequenced. Mutant RS1-RNA and protein expression were assessed by transfecting COS-7 cells with minigene constructs. All six males carried the RS1 c354del1-ins18 mutation in which an 18-bp insertion replaced nucleotide 354, duplicating the adjacent upstream intron 4-to-exon 5 junction and creating a premature termination codon downstream. Analysis indicated normal pre-mRNA splicing producing mRNA transcripts. Truncated RS1 protein was expressed transiently but was degraded rapidly by a proteasomal pathway rather than by nonsense-mediated mRNA decay. Two boys, 1.5 and 5 years of age, had foveal cysts and minimal peripheral schisis, and retained near-normal scotopic b-wave amplitude and normal ERG waveforms. The 5-year-old's ERG was diminished when repeated 3 years later. Four older XLRS relatives 32 to 45 years old had substantial b-wave loss and strongly electronegative ERGs; three had overt macular atrophy. Cross-sectional family analysis showed the b-/a-wave amplitude ratio as inversely related to age in the six males. The c354del1-ins18 mutation caused an RS1-null biochemical phenotype and a progressive clinical phenotype in a 5-year-old boy, whereas the older XLRS relatives had macular atrophy and marked ERG changes. The phenotypic heterogeneity with age by cross-sectional study of this family mutation argues that XLRS disease is not stationary and raises questions regarding factors involved in progression. JF - Investigative ophthalmology & visual science AU - Vijayasarathy, Camasamudram AU - Ziccardi, Lucia AU - Zeng, Yong AU - Smaoui, Nizar AU - Caruso, Rafael C AU - Sieving, Paul A AD - Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 5375 EP - 5383 VL - 50 IS - 11 KW - Eye Proteins KW - 0 KW - RNA, Messenger KW - RS1 protein, human KW - Index Medicus KW - Pedigree KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Child, Preschool KW - Phenotype KW - Mutagenesis, Site-Directed KW - Exons -- genetics KW - Infant KW - Cross-Sectional Studies KW - Visual Acuity -- physiology KW - Transfection KW - Adult KW - COS Cells -- metabolism KW - Cercopithecus aethiops KW - Macula Lutea -- pathology KW - Middle Aged KW - Atrophy KW - Tomography, Optical Coherence KW - Male KW - Electroretinography KW - Frameshift Mutation KW - Retinoschisis -- genetics KW - Retinoschisis -- physiopathology KW - Eye Proteins -- genetics KW - Retina -- physiopathology KW - Retinoschisis -- diagnosis KW - INDEL Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734121474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Null+retinoschisin-protein+expression+from+an+RS1+c354del1-ins18+mutation+causing+progressive+and+severe+XLRS+in+a+cross-sectional+family+study.&rft.au=Vijayasarathy%2C+Camasamudram%3BZiccardi%2C+Lucia%3BZeng%2C+Yong%3BSmaoui%2C+Nizar%3BCaruso%2C+Rafael+C%3BSieving%2C+Paul+A&rft.aulast=Vijayasarathy&rft.aufirst=Camasamudram&rft.date=2009-11-01&rft.volume=50&rft.issue=11&rft.spage=5375&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.09-3839 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-04 N1 - Date created - 2009-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Retina. 2006 Oct;26(8):940-6 [17031297] Retina. 2006 Sep;26(7 Suppl):S61-4 [16946682] Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3837-45 [17652759] Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4200-8 [17724207] Genetics. 2008 Mar;178(3):1785-94 [18245825] Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3677-86 [18660429] Mol Vis. 2008;14:1549-58 [18728755] Mol Vis. 2008;14:2321-32 [19093009] Br J Ophthalmol. 2009 Mar;93(3):373-8 [19019942] J Med Genet. 1999 Dec;36(12):932-4 [10636740] Hum Mol Genet. 2000 Jul 22;9(12):1873-9 [10915776] Doc Ophthalmol. 1999;98(2):153-73 [10947001] Hum Mutat. 2000 Oct;16(4):307-14 [11013441] Invest Ophthalmol Vis Sci. 2001 Mar;42(3):816-25 [11222545] Vision Res. 2001 Dec;41(28):3931-42 [11738458] J Clin Invest. 2002 Jan;109(1):3-6 [11781342] J Neurosci. 2003 Jul 9;23(14):6030-40 [12853421] J Biol Chem. 2003 Jul 25;278(30):28139-46 [12746437] Surv Ophthalmol. 2004 Mar-Apr;49(2):214-30 [14998693] Graefes Arch Clin Exp Ophthalmol. 2004 Jul;242(7):561-5 [14986011] Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3279-85 [15326152] Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3302-12 [15326155] Trans Ophthalmol Soc U K. 1970;89:29-39 [5276662] Can J Ophthalmol. 1973 Jul;8(3):385-93 [4742888] Am J Ophthalmol. 1977 Jun;83(6):853-5 [868987] Arch Ophthalmol. 1981 Nov;99(11):1998-9 [7295149] Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(4):315-23 [6915726] Arch Ophthalmol. 1987 Apr;105(4):513-6 [3566604] Graefes Arch Clin Exp Ophthalmol. 1990;228(5):432-7 [2227486] Trans Am Ophthalmol Soc. 1990;88:211-25; discussion 226-8 [2095022] Int Ophthalmol Clin. 1993 Spring;33(2):193-202 [8325733] Arch Ophthalmol. 1993 Aug;111(8):1080-6 [8352691] Br J Ophthalmol. 1995 Jul;79(7):697-702 [7662639] Hum Mol Genet. 1997 Jun;6(6):881-5 [9175734] Nat Genet. 1997 Oct;17(2):164-70 [9326935] Can J Ophthalmol. 1998 Apr;33(3):149-58 [9606571] Hum Mol Genet. 1998 Jul;7(7):1185-92 [9618178] Eur J Hum Genet. 1999 Apr;7(3):368-76 [10234514] FASEB J. 1999;13 Suppl:S77-82 [10352148] Hum Genet. 1999 May;104(5):435-7 [10394938] Am J Ophthalmol. 1999 Aug;128(2):179-84 [10458173] Glia. 2005 Feb;49(3):397-406 [15538749] Ophthalmic Genet. 2005 Sep;26(3):111-7 [16272055] Br J Ophthalmol. 2005 Dec;89(12):1663-4 [16299154] Br J Ophthalmol. 2006 Jan;90(1):81-6 [16361673] FEBS Lett. 2007 Jun 19;581(15):2845-53 [17531985] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.09-3839 ER - TY - JOUR T1 - PINK1 mutations: does the dosage make the poison? AN - 734116827; 19862834 JF - Human mutation AU - Scholz, Sonja W AD - National Institute on Aging. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1 VL - 30 IS - 11 KW - Protein Kinases KW - EC 2.7.- KW - PTEN-induced putative kinase KW - EC 2.7.11.1 KW - Index Medicus KW - Humans KW - Genetic Predisposition to Disease KW - Parkinson Disease -- genetics KW - Protein Kinases -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734116827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+mutation&rft.atitle=PINK1+mutations%3A+does+the+dosage+make+the+poison%3F&rft.au=Scholz%2C+Sonja+W&rft.aulast=Scholz&rft.aufirst=Sonja&rft.date=2009-11-01&rft.volume=30&rft.issue=11&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=Human+mutation&rft.issn=1098-1004&rft_id=info:doi/10.1002%2Fhumu.21139 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-25 N1 - Date created - 2009-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Hum Mutat. 2009 Nov;30(11):1551-7 [19847793] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/humu.21139 ER - TY - JOUR T1 - Height, body mass index, and physical activity in relation to glioma risk. AN - 734114065; 19808953 AB - Whether energy balance during early life and/or adulthood is related to glioma risk is unknown. We therefore investigated height, body mass index (BMI), and physical activity in relation to glioma risk in the prospective NIH-AARP Diet and Health Study. Participants completed a baseline questionnaire (sent in 1995-1996) inquiring about height, weight, and potential confounders. A second questionnaire (sent in 1996) inquired about physical activity during ages 15 to 18, 19 to 29, and 35 to 39 years and the past 10 years and body weight at ages 18, 35, and 50 years. During follow-up from 1995/1996 to 2003, we documented 480 cases of glioma among 499,437 respondents to the baseline questionnaire and 257 cases among 305,681 respondents to the second questionnaire. Glioma risk among tall persons (>or=1.90 m) was twice that of short persons [<1.60 m; multivariate relative risk (RR), 2.12; 95% confidence interval (95% CI), 1.18-3.81; P(trend) = 0.006]. Risk among participants who were obese (BMI 30.0-34.9 kg/m(2)) at age 18 years was nearly four times that of persons of normal weight (BMI 18.5-24.9 kg/m(2)) at age 18 years (RR, 3.74; 95% CI, 2.03-6.90; P(trend) = 0.003); 11 cases were obese at age 18 years. Risk among participants who were active during ages 15 to 18 years was 36% lower than that of persons who were inactive during ages 15 to 18 years (RR, 0.64; 95% CI, 0.44-0.93; P(trend) = 0.02). BMI and physical activity after age 18 years were unrelated to glioma risk. Adult height, BMI during adolescence, and physical activity during adolescence were each associated with glioma risk, supporting a role for early-life energy balance in glioma carcinogenesis. JF - Cancer research AU - Moore, Steven C AU - Rajaraman, Preetha AU - Dubrow, Robert AU - Darefsky, Amy S AU - Koebnick, Corinna AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch and Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA. moorest@mail.nih.gov Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 8349 EP - 8355 VL - 69 IS - 21 KW - Index Medicus KW - Young Adult KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Waist Circumference KW - Adolescent KW - Male KW - Brain Neoplasms -- epidemiology KW - Body Height KW - Glioma -- epidemiology KW - Exercise KW - Body Mass Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734114065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Height%2C+body+mass+index%2C+and+physical+activity+in+relation+to+glioma+risk.&rft.au=Moore%2C+Steven+C%3BRajaraman%2C+Preetha%3BDubrow%2C+Robert%3BDarefsky%2C+Amy+S%3BKoebnick%2C+Corinna%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2009-11-01&rft.volume=69&rft.issue=21&rft.spage=8349&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-1669 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-10-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] PLoS Genet. 2006 Mar;2(3):e41 [16565746] Ann Epidemiol. 2008 Sep;18(9):682-95 [18794009] Ann Intern Med. 2008 Oct 7;149(7):461-71, W83-8 [18838726] Nat Genet. 2009 Jan;41(1):25-34 [19079261] Econ Hum Biol. 2009 Mar;7(1):109-12 [19195938] Endocr Rev. 2001 Feb;22(1):53-74 [11159816] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Epidemiol Rev. 2001;23(2):313-42 [12192740] Cancer Epidemiol Biomarkers Prev. 2003 Mar;12(3):223-5 [12646512] Horm Metab Res. 2003 Nov-Dec;35(11-12):694-704 [14710348] Am J Clin Nutr. 2004 Jul;80(1):185-92 [15213047] Neurology. 2004 Jul 27;63(2):276-81 [15277620] Neuroepidemiology. 1989;8(6):277-82 [2586697] Cancer Causes Control. 1992 Jul;3(4):349-54 [1617122] N Engl J Med. 1992 Nov 5;327(19):1350-5 [1406836] Epidemiology. 1995 Jan;6(1):61-6 [7888448] World Health Organ Tech Rep Ser. 1995;854:1-452 [8594834] Epidemiol Rev. 1995;17(2):382-414 [8654518] Diabetologia. 1997 Jul;40 Suppl 2:S25-31 [9248698] Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):863-73 [9367058] Med Sci Sports Exerc. 2004 Dec;36(12):2082-7 [15570143] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Am J Epidemiol. 2005 Aug 1;162(3):267-78 [15987729] J Clin Oncol. 2005 Jul 20;23(21):4742-54 [16034050] Endocr Rev. 2005 Dec;26(7):916-43 [16131630] Br J Cancer. 2008 Jul 8;99(1):185-90 [18560401] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-1669 ER - TY - JOUR T1 - Identification of chemical compounds that induce HIF-1alpha activity. AN - 734111768; 19502547 AB - Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF-1 is a heterodimeric transcription factor composed of hypoxia-inducible HIF-1alpha and constitutively expressed HIF-1beta. Under hypoxic conditions, the two subunits dimerize, allowing translocation of the HIF-1 complex to the nucleus where it binds to hypoxia-response elements (HREs) and activates expression of target genes implicated in angiogenesis, cell growth, and survival. The HIF-1 pathway is essential to normal growth and development, and is involved in the pathophysiology of cancer, inflammation, and ischemia. Thus, there is considerable interest in identifying compounds that modulate the HIF-1 signaling pathway. To assess the ability of environmental chemicals to stimulate the HIF-1 signaling pathway, we screened a National Toxicology Program collection of 1408 compounds using a cell-based beta-lactamase HRE reporter gene assay in a quantitative high-throughput screening (qHTS) format. Twelve active compounds were identified. These compounds were tested in a confirmatory assay for induction of vascular endothelial growth factor, a known hypoxia target gene, and confirmed compounds were further tested for their ability to mimic the effect of a reduced-oxygen environment on hypoxia-regulated promoter activity. Based on this testing strategy, three compounds (o-phenanthroline, iodochlorohydroxyquinoline, cobalt sulfate heptahydrate) were confirmed as hypoxia mimetics, whereas two compounds (7-diethylamino-4-methylcoumarin and 7,12-dimethylbenz(a)anthracence) were found to interact with HIF-1 in a manner different from hypoxia. These results demonstrate the effectiveness of qHTS in combination with secondary assays for identification of HIF-1alpha inducers and for distinguishing among inducers based on their pattern of activated hypoxic target genes. Identification of environmental compounds having HIF-1alpha activation activity in cell-based assays may be useful for prioritizing chemicals for further testing as hypoxia-response inducers in vivo. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Xia, Menghang AU - Huang, Ruili AU - Sun, Yi AU - Semenza, Gregg L AU - Aldred, Shelley Force AU - Witt, Kristine L AU - Inglese, James AU - Tice, Raymond R AU - Austin, Christopher P AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mxia@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 153 EP - 163 VL - 112 IS - 1 KW - HIF1A protein, human KW - 0 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Phenanthrolines KW - Cobalt KW - 3G0H8C9362 KW - Clioquinol KW - 7BHQ856EJ5 KW - beta-Lactamases KW - EC 3.5.2.6 KW - cobalt sulfate KW - H7965X29HX KW - 1,10-phenanthroline KW - W4X6ZO7939 KW - Index Medicus KW - Clioquinol -- pharmacology KW - Phenanthrolines -- pharmacology KW - Genes, Reporter KW - Cobalt -- pharmacology KW - Drug Evaluation, Preclinical KW - Signal Transduction KW - Cell Line KW - beta-Lactamases -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- drug effects KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734111768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Identification+of+chemical+compounds+that+induce+HIF-1alpha+activity.&rft.au=Xia%2C+Menghang%3BHuang%2C+Ruili%3BSun%2C+Yi%3BSemenza%2C+Gregg+L%3BAldred%2C+Shelley+Force%3BWitt%2C+Kristine+L%3BInglese%2C+James%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Xia&rft.aufirst=Menghang&rft.date=2009-11-01&rft.volume=112&rft.issue=1&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp123 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-21 N1 - Date created - 2009-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jul 14;275(28):21048-54 [10777486] Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2889-97 [11087245] Science. 2001 Apr 20;292(5516):464-8 [11292862] Science. 2001 Apr 20;292(5516):468-72 [11292861] J Biol Chem. 2001 Apr 27;276(17):14374-84 [11278521] Curr Opin Genet Dev. 2001 Jun;11(3):293-9 [11377966] Trends Mol Med. 2001 Aug;7(8):345-50 [11516994] Science. 2002 Feb 1;295(5556):858-61 [11823643] Cancer Treat Rev. 2003 Aug;29(4):297-307 [12927570] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Cancer Biol Ther. 2004 Jan;3(1):29-35 [14726713] J Natl Cancer Inst. 1970 Jul;45(1):107-22 [4317734] Blood. 1993 Dec 15;82(12):3610-5 [8260699] J Biol Chem. 1995 Jan 20;270(3):1230-7 [7836384] J Biol Chem. 1995 Sep 8;270(36):21021-7 [7673128] J Biol Chem. 1995 Dec 29;270(52):31189-95 [8537383] Mol Cell Biol. 1996 Sep;16(9):4604-13 [8756616] J Biol Chem. 1996 Dec 20;271(51):32529-37 [8955077] J Biol Chem. 1997 Sep 5;272(36):22642-7 [9278421] EMBO J. 1998 Jun 1;17(11):3005-15 [9606183] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92 [9653127] J Biol Chem. 1999 Aug 20;274(34):24142-6 [10446187] Cancer Res. 1999 Aug 15;59(16):3915-8 [10463582] J Cancer Res Clin Oncol. 1999 Aug-Sep;125(8-9):525-8 [10480347] Int J Biochem Cell Biol. 2005 Mar;37(3):535-40 [15618010] Cancer Res. 2005 Jun 1;65(11):4918-28 [15930314] Sci STKE. 2005 Oct 18;2005(306):re12 [16234508] Exp Physiol. 2005 Nov;90(6):791-7 [16157658] Novartis Found Symp. 2006;272:15-25; discussion 25-36 [16686427] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] J Biol Chem. 2006 Nov 10;281(45):34056-63 [16973622] Cell Mol Life Sci. 2007 Jan;64(2):192-205 [17180300] Trends Biochem Sci. 2007 Aug;32(8):389-97 [17624786] Science. 2008 Feb 15;319(5865):906-7 [18276874] J Pineal Res. 2008 Mar;44(2):121-6 [18289162] Oncogene. 2008 Feb 28;27(10):1404-11 [17828303] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] Pediatr Nephrol. 2008 May;23(5):681-94 [17955264] Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7 [19196967] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp123 ER - TY - JOUR T1 - Don't forget to polarize your lenses! Talc in the liver. AN - 734103053; 19866528 JF - Gastroenterology AU - Koh, Christopher AU - Kleiner, David E AU - Heller, Theo AD - Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health Bethesda, Maryland, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - e3 EP - e4 VL - 137 IS - 5 KW - Talc KW - 14807-96-6 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Female KW - Hepatitis C, Chronic -- etiology KW - Substance Abuse, Intravenous -- pathology KW - Substance Abuse, Intravenous -- complications KW - Microscopy, Polarization KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734103053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Don%27t+forget+to+polarize+your+lenses%21+Talc+in+the+liver.&rft.au=Koh%2C+Christopher%3BKleiner%2C+David+E%3BHeller%2C+Theo&rft.aulast=Koh&rft.aufirst=Christopher&rft.date=2009-11-01&rft.volume=137&rft.issue=5&rft.spage=e3&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-03 N1 - Date created - 2009-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Forensic Sci Int. 1982 Sep-Oct;20(2):141-51 [7118025] J Clin Gastroenterol. 1987 Apr;9(2):198-203 [3571894] Am J Gastroenterol. 1995 Dec;90(12):2164-6 [8540508] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Hermes transposon of Musca domestica and its use as a mutagen of Schizosaccharomyces pombe. AN - 734090842; 19450689 AB - Transposon mutagenesis allows for the discovery and characterization of genes by creating mutations that can be easily mapped and sequenced. Moreover, this method allows for a relatively unbiased approach to isolating genes of interest. Recently, a system of transposon based mutagenesis for Schizosaccharomyces pombe became available. This mutagenesis relies on Hermes, a DNA transposon from the house fly that readily integrates into the chromosomes of S. pombe. The Hermes system is distinct from the retrotransposons of S. pombe because it efficiently integrates into open reading frames. To mutagenize S. pombe, cells are transformed with a plasmid that contains a drug resistance marker flanked by the terminal inverted repeats of Hermes. The Hermes transposase expressed from a second plasmid excises the resistance marker with the inverted repeats and inserts this DNA into chromosomal sites. After S. pombe with these two plasmids grow 25 generations, approximately 2% of the cells contain insertions. Of the cells with insertions, 68% contain single integration events. The protocols listed here provide the detailed information necessary to mutagenize a strain of interest, screen for specific phenotypes, and sequence the positions of insertion. JF - Methods (San Diego, Calif.) AU - Park, Jung M AU - Evertts, Adam G AU - Levin, Henry L AD - Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 243 EP - 247 VL - 49 IS - 3 KW - DNA Transposable Elements KW - 0 KW - Index Medicus KW - Animals KW - Plasmids KW - Schizosaccharomyces -- genetics KW - Houseflies -- genetics KW - Mutagenesis, Insertional -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734090842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+%28San+Diego%2C+Calif.%29&rft.atitle=The+Hermes+transposon+of+Musca+domestica+and+its+use+as+a+mutagen+of+Schizosaccharomyces+pombe.&rft.au=Park%2C+Jung+M%3BEvertts%2C+Adam+G%3BLevin%2C+Henry+L&rft.aulast=Park&rft.aufirst=Jung&rft.date=2009-11-01&rft.volume=49&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Methods+%28San+Diego%2C+Calif.%29&rft.issn=1095-9130&rft_id=info:doi/10.1016%2Fj.ymeth.2009.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-28 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Nov 25;402(6760):413-8 [10586881] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5586-8 [12732725] Cell. 2003 Oct 17;115(2):135-8 [14567911] Nat Genet. 2004 Mar;36(3):283-7 [14981521] Nucleic Acids Res. 1993 Jun 25;21(12):2955-6 [8332516] Methods Mol Biol. 2008;420:97-117 [18641943] Genetics. 2007 Mar;175(3):1505-31 [17194782] Nat Protoc. 2007;2(5):1276-87 [17546024] Mol Cell. 2007 Jul 20;27(2):289-99 [17643377] Genome Biol. 2007;8 Suppl 1:S1 [18047686] Genetics. 2007 Dec;177(4):2519-23 [17947404] Yeast. 2006 Feb;23(3):173-83 [16498704] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ymeth.2009.05.004 ER - TY - JOUR T1 - Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey. AN - 734086726; 19686844 AB - The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype. JF - Neurotoxicology and teratology AU - Krieg, Edward F AU - Butler, Mary Ann AU - Chang, Man-huei AU - Liu, Tiebin AU - Yesupriya, Ajay AU - Lindegren, Mary Lou AU - Dowling, Nicole AU - CDC/NCI NHANES III Genomics Working Group AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, Ohio 45226, USA. erk3@cdc.gov ; CDC/NCI NHANES III Genomics Working Group PY - 2009 SP - 364 EP - 371 VL - 31 IS - 6 KW - Environmental Pollutants KW - 0 KW - Homocysteine KW - 0LVT1QZ0BA KW - Lead KW - 2P299V784P KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Index Medicus KW - Homocysteine -- blood KW - Polymorphism, Single Nucleotide KW - Age Factors KW - Humans KW - Aged KW - Child KW - Genotype KW - Psychomotor Performance -- drug effects KW - Aged, 80 and over KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Mental Recall -- drug effects KW - Adolescent KW - Male KW - Female KW - Lead Poisoning -- blood KW - Cognition -- drug effects KW - Lead -- toxicity KW - Lead Poisoning -- genetics KW - Lead Poisoning -- psychology KW - Nutrition Surveys KW - Porphobilinogen Synthase -- genetics KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734086726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Lead+and+cognitive+function+in+ALAD+genotypes+in+the+third+National+Health+and+Nutrition+Examination+Survey.&rft.au=Krieg%2C+Edward+F%3BButler%2C+Mary+Ann%3BChang%2C+Man-huei%3BLiu%2C+Tiebin%3BYesupriya%2C+Ajay%3BLindegren%2C+Mary+Lou%3BDowling%2C+Nicole%3BCDC%2FNCI+NHANES+III+Genomics+Working+Group&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2009-11-01&rft.volume=31&rft.issue=6&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2009.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-07 N1 - Date created - 2009-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2009.08.003 ER - TY - JOUR T1 - Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane. AN - 734083952; 19614667 AB - The Salmonella type III effector, SopB, is an inositol polyphosphate phosphatase that modulates host cell phospholipids at the plasma membrane and the nascent Salmonella-containing vacuole (SCV). Translocated SopB persists for many hours after infection and is ubiquitinated but the significance of this covalent modification has not been investigated. Here we identify by mass spectrometry six lysine residues of SopB that are mono-ubiquitinated. Substitution of these six lysine residues with arginine, SopB-K(6)R, almost completely eliminated SopB ubiquitination. We found that ubiquitination does not affect SopB stability or membrane association, or SopB-dependent events in SCV biogenesis. However, two spatially and temporally distinct events are dependent on ubiquitination, downregulation of SopB activity at the plasma membrane and prolonged retention of SopB on the SCV. Activation of the mammalian pro-survival kinase Akt/PKB, a downstream target of SopB, was intensified and prolonged after infection with the SopB-K(6)R mutant. At later times, fewer SCV were decorated with SopB-K(6)R compared with SopB. Instead SopB-K(6)R was present as discrete vesicles spread diffusely throughout the cell. Altogether, our data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization. JF - Cellular microbiology AU - Knodler, Leigh A AU - Winfree, Seth AU - Drecktrah, Dan AU - Ireland, Robin AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA. lknodler@niaid.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1652 EP - 1670 VL - 11 IS - 11 KW - Bacterial Proteins KW - 0 KW - Virulence Factors KW - SopB protein, Salmonella KW - EC 3.4.- KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - HeLa Cells KW - Amino Acid Substitution -- genetics KW - Protein Stability KW - Humans KW - Ubiquitination KW - Lysine -- genetics KW - Lysine -- metabolism KW - Virulence Factors -- metabolism KW - Salmonella -- pathogenicity KW - Bacterial Proteins -- metabolism KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734083952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=Ubiquitination+of+the+bacterial+inositol+phosphatase%2C+SopB%2C+regulates+its+biological+activity+at+the+plasma+membrane.&rft.au=Knodler%2C+Leigh+A%3BWinfree%2C+Seth%3BDrecktrah%2C+Dan%3BIreland%2C+Robin%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2009-11-01&rft.volume=11&rft.issue=11&rft.spage=1652&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=1462-5822&rft_id=info:doi/10.1111%2Fj.1462-5822.2009.01356.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-14 N1 - Date created - 2009-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: PLoS Pathog. 2007 Jan;3(1):e3 [17257058] J Clin Invest. 2007 Feb;117(2):419-27 [17235393] J Biol Chem. 2007 Apr 6;282(14):10567-75 [17259170] Cell. 2008 May 2;133(3):486-97 [18455989] Infect Immun. 2008 Jun;76(6):2722-35 [18411289] Cell. 2009 Apr 17;137(2):283-94 [19379694] Biochim Biophys Acta. 2006 Dec;1764(12):1940-7 [17055348] Cell. 2007 Jan 12;128(1):129-39 [17218260] Cell. 2007 Jan 12;128(1):141-56 [17218261] Science. 2007 Jan 12;315(5809):201-5 [17218518] Infect Immun. 1999 Dec;67(12):6385-93 [10569754] Mol Cell Biol Res Commun. 1999 Aug;2(2):111-8 [10542134] J Biol Chem. 2000 Dec 1;275(48):37718-24 [10978351] Int J Med Microbiol. 2000 Dec;290(7):605-17 [11200542] Cell Microbiol. 1999 Jul;1(1):33-49 [11207539] J Bacteriol. 2001 Apr;183(7):2348-58 [11244077] EMBO J. 2001 Mar 15;20(6):1245-58 [11250891] FEBS Lett. 2001 Apr 13;494(3):201-7 [11311241] Curr Biol. 2001 Oct 16;11(20):1636-42 [11676927] Infect Immun. 2002 Mar;70(3):1619-22 [11854253] Biochemistry. 2002 Apr 23;41(16):5067-74 [11955054] Cell Microbiol. 2002 Jul;4(7):435-46 [12102689] Nat Cell Biol. 2003 May;5(5):461-6 [12717448] Mol Microbiol. 2003 Aug;49(3):685-704 [12864852] Curr Opin Cell Biol. 2003 Aug;15(4):446-55 [12892785] J Biol Chem. 2003 Sep 19;278(38):35857-60 [12860974] Cell. 2003 Oct 31;115(3):333-42 [14636560] Oncogene. 2004 Mar 15;23(11):2057-70 [15021893] Science. 2004 Jun 18;304(5678):1805-7 [15205533] Mol Cell Biol. 2004 Nov;24(21):9592-600 [15485925] Biochim Biophys Acta. 1975 Mar 25;415(1):29-79 [1091302] Nature. 1981 May 21;291(5812):238-9 [7015147] J Cell Biol. 1982 Apr;93(1):97-102 [7068762] J Immunol Methods. 1986 Mar 13;87(2):169-77 [3950427] Gene. 1991 Apr;100:195-9 [2055470] Infect Immun. 1993 May;61(5):1707-14 [8478058] J Biol Chem. 1994 May 13;269(19):14244-7 [8188707] J Biol Chem. 1997 Nov 7;272(45):28557-62 [9353319] J Biol Chem. 1998 Feb 6;273(6):3117-20 [9452416] J Bacteriol. 1998 Apr;180(7):1793-802 [9537377] Mol Microbiol. 1998 Oct;30(1):175-88 [9786194] Curr Biol. 1999 Apr 22;9(8):433-6 [10226029] Proteomics. 2004 Nov;4(11):3376-82 [15468071] Mol Nutr Food Res. 2004 Dec;48(7):496-503 [15538712] Bioinformatics. 2004 Dec 12;20(18):3302-7 [15256413] Cell Microbiol. 2005 Jan;7(1):105-13 [15617527] Infect Immun. 2005 Jan;73(1):146-54 [15618149] J Neurosci. 2005 Feb 23;25(8):2002-9 [15728840] J Biol Chem. 2005 Mar 11;280(10):9058-64 [15642738] Indian J Exp Biol. 2005 Jul;43(7):631-4 [16053270] Nat Rev Mol Cell Biol. 2005 Aug;6(8):599-609 [16064136] J Biol Chem. 2005 Nov 18;280(46):38682-8 [16176924] Cell Microbiol. 2006 Feb;8(2):353-64 [16441444] Traffic. 2006 Jan;7(1):39-51 [16445685] Mol Cell. 2006 Mar 17;21(6):737-48 [16543144] Indian J Med Res. 2006 Jan;123(1):83-8 [16567873] Physiol Rev. 2006 Apr;86(2):669-707 [16601271] J Immunol. 2006 May 15;176(10):6093-102 [16670318] Cell Microbiol. 2006 Aug;8(8):1294-309 [16882033] Infect Immun. 2006 Oct;74(10):5645-57 [16988240] J Proteomics. 2008 Apr 30;71(1):97-108 [18541478] J Cell Biol. 2008 Aug 25;182(4):741-52 [18725540] PLoS One. 2008;3(10):e3422 [18923646] Oncogene. 2008 Oct 27;27(50):6473-88 [18955974] Biochim Biophys Acta. 2008 Dec;1782(12):809-16 [18817868] Mol Cell. 2009 Feb 13;33(3):275-86 [19217402] Biochem J. 2009 Apr 1;419(1):57-63 [19125695] Annu Rev Cell Dev Biol. 2006;22:159-80 [16753028] Mol Microbiol. 2006 Nov;62(4):928-40 [17038123] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1462-5822.2009.01356.x ER - TY - JOUR T1 - The impact of dosimetry uncertainties on dose-response analyses. AN - 734081577; 19820458 AB - Radiation dose estimates used in epidemiological studies are subject to many sources of uncertainty, and the error structure may be a complicated mixture of different types of error. Increasingly, efforts are being made to evaluate dosimetry uncertainties and to take account of them in statistical analyses. The impact of these uncertainties on dose-response analyses depends on the magnitude and type of error. Errors that are independent from subject to subject (random errors) reduce statistical power for detecting a dose-response relationship, increase uncertainties in estimated risk coefficients, and may lead to underestimation of risk coefficients. The specific effects of random errors depend on whether the errors are "classical" or "Berkson." Classical error can be thought of as error that arises from an imprecise measuring device, whereas Berkson error occurs when a single dose is used to represent a group of subjects (with varying true doses). Uncertainties in quantities that are common to some or all subjects are "shared" uncertainties. Such uncertainties increase the possibility of bias, and accounting for this possibility increases the length of confidence intervals. In studies that provide a direct evaluation of risk at low doses and dose rates, dosimetry errors are more likely to mask a true effect than to create a spurious one. In addition, classical errors and shared dosimetry uncertainties increase the potential for bias in estimated risks coefficients, but this potential may already be large due to the extreme vulnerability to confounding in studies involving very small relative risk. JF - Health physics AU - Gilbert, Ethel S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 7050, Bethesda, MD 20892, USA. gilberte@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 487 EP - 492 VL - 97 IS - 5 KW - Index Medicus KW - Radiation Dosage KW - Epidemiologic Studies KW - Humans KW - Environmental Exposure KW - Uncertainty KW - Dose-Response Relationship, Radiation KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734081577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=The+impact+of+dosimetry+uncertainties+on+dose-response+analyses.&rft.au=Gilbert%2C+Ethel+S&rft.aulast=Gilbert&rft.aufirst=Ethel&rft.date=2009-11-01&rft.volume=97&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2FHP.0b013e3181adc3b1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-01 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2002 Mar 15;155(6):554-64 [11882529] Health Phys. 2009 Nov;97(5):481-6 [19820457] Radiat Res. 2003 Oct;160(4):408-17 [12968933] Radiat Res. 2004 Mar;161(3):359-68 [14982478] Radiat Res. 1990 Sep;123(3):275-84 [2217725] Am J Epidemiol. 1990 Dec;132(6):1176-84 [2260550] Annu Rev Public Health. 1993;14:69-93 [8323607] Health Phys. 1997 Feb;72(2):269-76 [9003712] Health Phys. 1998 Jan;74(1):22-9 [9415578] Br J Cancer. 1998 Aug;78(3):394-408 [9703290] Stat Med. 1998 Oct 15;17(19):2157-77 [9802176] Health Phys. 1999 Sep;77(3):265-75 [10456497] Health Phys. 2005 Feb;88(2):125-32 [15650587] BMJ. 2005 Jul 9;331(7508):77 [15987704] Radiat Res. 2005 Aug;164(2):111-22 [16038582] Radiat Res. 2006 Jul;166(1 Pt 2):168-73 [16808605] Radiat Res. 2006 Jul;166(1 Pt 2):303-12 [16808615] Radiat Res. 2007 Apr;167(4):380-95 [17388692] Radiat Res. 2007 Apr;167(4):396-416 [17388693] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Radiat Res. 2007 Dec;168(6):757-63 [18088178] Biometrics. 2001 Sep;57(3):689-97 [11550916] Biometrics. 2002 Mar;58(1):13-20 [11890308] Am J Epidemiol. 2001 Feb 15;153(4):319-22; discussion 323-4 [11207147] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/HP.0b013e3181adc3b1 ER - TY - JOUR T1 - Extended urinary Delta9-tetrahydrocannabinol excretion in chronic cannabis users precludes use as a biomarker of new drug exposure. AN - 734044681; 19631478 AB - Generally, urinary 11-nor-9-carboxy-Delta9-tetrahydrocannabinol (THCCOOH) after alkaline hydrolysis is monitored to detect cannabis exposure, although last use may have been weeks prior in chronic cannabis users. Delta9-Tetrahydrocannabinol (THC) and 11-hydroxy-THC (11-OH-THC) concentrations in urine following Escherichia coli beta-glucuronidase hydrolysis were proposed as biomarkers of recent (within 8h) cannabis use. To test the validity of THC and 11-OH-THC in urine as indicators of recent cannabis use. Monitor urinary cannabinoid excretion in 33 chronic cannabis smokers who resided on a secure research unit under 24h continuous medical surveillance. All urine specimens were collected individually ad libidum for up to 30 days, were hydrolyzed with a tandem E. coli beta-glucuronidase/base procedure, and analyzed for THC, 11-OH-THC and THCCOOH by one- and two-dimensional-cryotrap gas chromatography mass spectrometry (2D-GCMS) with limits of quantification of 2.5 ng/mL. Extended excretion of THC and 11-OH-THC in chronic cannabis users' urine was observed during monitored abstinence; 14 of 33 participants had measurable THC in specimens collected at least 24h after abstinence initiation. Seven subjects had measurable THC in urine for 3, 3, 4, 7, 7, 12, and 24 days after cannabis cessation. 11-OH-THC and THCCOOH were detectable in urine specimens from one heavy, chronic cannabis user for at least 24 days. For the first time, extended urinary excretion of THC and 11-OH-THC is documented for at least 24 days, negating their effectiveness as biomarkers of recent cannabis exposure, and substantiating long terminal elimination times for urinary cannabinoids following chronic cannabis smoking. JF - Drug and alcohol dependence AU - Lowe, Ross H AU - Abraham, Tsadik T AU - Darwin, William D AU - Herning, Ronald AU - Cadet, Jean Lud AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 05A721, Baltimore, MD 21224, USA. Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 24 EP - 32 VL - 105 IS - 1-2 KW - Biomarkers KW - 0 KW - 11-hydroxy-delta(9)-tetrahydrocannabinol KW - 26108-40-7 KW - Dronabinol KW - 7J8897W37S KW - delta(9)-tetrahydrocannabinolic acid KW - EJ6CZV0K5Y KW - Index Medicus KW - Young Adult KW - Ethnic Groups KW - Humans KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Substance-Related Disorders -- urine KW - Substance-Related Disorders -- complications KW - Chronic Disease KW - Male KW - Female KW - Marijuana Abuse -- urine KW - Dronabinol -- analogs & derivatives KW - Substance Abuse Detection -- methods KW - Dronabinol -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734044681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Extended+urinary+Delta9-tetrahydrocannabinol+excretion+in+chronic+cannabis+users+precludes+use+as+a+biomarker+of+new+drug+exposure.&rft.au=Lowe%2C+Ross+H%3BAbraham%2C+Tsadik+T%3BDarwin%2C+William+D%3BHerning%2C+Ronald%3BCadet%2C+Jean+Lud%3BHuestis%2C+Marilyn+A&rft.aulast=Lowe&rft.aufirst=Ross&rft.date=2009-11-01&rft.volume=105&rft.issue=1-2&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=1879-0046&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.05.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-30 N1 - Date created - 2009-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Forensic Sci Int. 2004 Jul 16;143(2-3):147-52 [15240035] Forensic Sci Int. 2003 Nov 26;137(2-3):196-202 [14609657] Am J Psychiatry. 1982 Sep;139(9):1196-8 [6287871] Clin Pharmacol Ther. 1985 Nov;38(5):572-8 [3902318] J Anal Toxicol. 1986 Mar-Apr;10(2):56-64 [3009969] J Anal Toxicol. 1989 Jul-Aug;13(4):218-23 [2550702] Eur J Clin Pharmacol. 1989;37(3):273-7 [2558889] J Anal Toxicol. 1990 May-Jun;14(3):176-80 [2165199] J Anal Toxicol. 1992 Jul-Aug;16(4):228-35 [1323733] J Anal Toxicol. 1995 Sep;19(5):285-91 [7500614] J Anal Toxicol. 1995 Sep;19(5):292-8 [7500615] J Anal Toxicol. 1995 Oct;19(6):443-9 [8926739] J Anal Toxicol. 1996 Oct;20(6):441-52 [8889681] Ther Drug Monit. 1998 Oct;20(5):570-6 [9780137] J Anal Toxicol. 1998 Oct;22(6):445-54 [9788519] J Anal Toxicol. 1999 Sep;23(5):323-32 [10488918] Neuroimage. 2004 Nov;23(3):914-20 [15528091] Drug Alcohol Depend. 2005 Jan 7;77(1):23-30 [15607838] Neurology. 2005 Feb 8;64(3):488-93 [15699380] Neuroimage. 2005 Jun;26(2):480-92 [15907305] Ther Drug Monit. 2006 Apr;28(2):155-63 [16628124] J Chromatogr A. 2007 Sep 7;1163(1-2):318-27 [17640656] J Anal Toxicol. 2007 Oct;31(8):477-85 [17988462] Sleep. 2008 Jun;31(6):901-8 [18548836] J Anal Toxicol. 2001 Oct;25(7):538-49 [11599597] Neurology. 2002 Nov 12;59(9):1337-43 [12427880] Ann N Y Acad Sci. 2003 May;993:75-8; discussion 79-81 [12853297] J Pharmacol Exp Ther. 1980 Oct;215(1):35-44 [6256518] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.05.027 ER - TY - JOUR T1 - Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment. AN - 733946025; 19692465 AB - The region of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 that engages its primary cellular receptor CD4 forms a site of vulnerability to neutralizing antibodies. The monoclonal antibody b12 exploits the conservation and accessibility of the CD4-binding site to neutralize many, though not all, HIV-1 isolates. To understand the basis of viral resistance to b12, we used the atomic-level definition of b12-gp120 contact sites to study a panel of diverse circulating viruses. A combination of sequence analysis, computational modeling, and site-directed mutagenesis was used to determine the influence of amino acid variants on binding and neutralization by b12. We found that several substitutions within the dominant b12 contact surface, called the CD4-binding loop, mediated b12 resistance, and that these substitutions resided just proximal to the known CD4 contact surface. Hence, viruses varied in key b12 contact residues that are proximal to, but not part of, the CD4 contact surface. This explained how viral isolates were able to evade b12 neutralization while maintaining functional binding to CD4. In addition, some viruses were resistant to b12 despite minimal sequence variation at b12 contact sites. Such neutralization resistance usually could be reversed by alterations at residues thought to influence the quaternary configuration of the viral envelope spike. To design immunogens that elicit neutralizing antibodies directed to the CD4-binding site, researchers need to address the antigenic variation within this region of gp120 and the restricted access to the CD4-binding site imposed by the native configuration of the trimeric viral envelope spike. JF - Journal of virology AU - Wu, Xueling AU - Zhou, Tongqing AU - O'Dell, Sijy AU - Wyatt, Richard T AU - Kwong, Peter D AU - Mascola, John R AD - Vaccine Research Center, NIAID, NIH, 40 Convent Dr., Bethesda, MD 20892, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 10892 EP - 10907 VL - 83 IS - 21 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD4 KW - Epitopes KW - HIV Envelope Protein gp120 KW - Index Medicus KW - Sequence Analysis, Protein KW - Mutagenesis, Site-Directed KW - Genetic Variation KW - Animals KW - Epitopes -- genetics KW - Sequence Alignment KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Epitopes -- chemistry KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - HIV-1 -- genetics KW - HIV-1 -- immunology KW - HIV Envelope Protein gp120 -- immunology KW - Antigens, CD4 -- genetics KW - HIV Envelope Protein gp120 -- chemistry KW - HIV Envelope Protein gp120 -- genetics KW - Antigens, CD4 -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733946025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mechanism+of+human+immunodeficiency+virus+type+1+resistance+to+monoclonal+antibody+B12+that+effectively+targets+the+site+of+CD4+attachment.&rft.au=Wu%2C+Xueling%3BZhou%2C+Tongqing%3BO%27Dell%2C+Sijy%3BWyatt%2C+Richard+T%3BKwong%2C+Peter+D%3BMascola%2C+John+R&rft.aulast=Wu&rft.aufirst=Xueling&rft.date=2009-11-01&rft.volume=83&rft.issue=21&rft.spage=10892&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01142-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):168-71 [11134947] J Virol. 2008 Jan;82(2):638-51 [17959660] J Virol. 2001 May;75(9):4208-18 [11287570] Br Med Bull. 2001;58:19-42 [11714622] J Virol. 2002 Oct;76(19):9888-99 [12208966] J Virol. 2003 Jan;77(1):642-58 [12477867] J Virol. 2003 Jan;77(2):1084-91 [12502824] Nature. 2003 Mar 20;422(6929):307-12 [12646921] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9 [12644702] Curr Mol Med. 2003 May;3(3):209-16 [12699358] J Virol. 2003 Jun;77(12):6965-78 [12768015] Virology. 2003 Sep 1;313(2):387-400 [12954207] Science. 2004 Mar 26;303(5666):2019-22 [15044802] J Virol. 2004 Jun;78(11):5651-7 [15140962] J Biol Chem. 1989 Sep 5;264(25):14587-90 [2670920] J Infect Dis. 1990 Sep;162(3):735-7 [2387997] Virology. 1991 Jun;182(2):635-43 [1708933] Virology. 1991 Nov;185(1):162-8 [1926772] J Acquir Immune Defic Syndr. 1992;5(3):303-7 [1740756] BMC Bioinformatics. 2007;8:460 [18034891] PLoS Med. 2008 Jan 3;5(1):e9 [18177204] Retrovirology. 2008;5:10 [18237398] J Virol. 2008 Jun;82(12):5807-14 [18385254] Nature. 2008 Sep 4;455(7209):109-13 [18668044] J Virol. 2008 Dec;82(23):11651-68 [18815292] J Virol. 2009 Jan;83(2):757-69 [18987148] J Virol. 2009 Jan;83(2):1045-59 [19004942] J Virol. 2009 Apr;83(8):3798-809 [19193800] Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9339-43 [1384050] J Mol Graph. 1993 Jun;11(2):139-41 [8347567] J Acquir Immune Defic Syndr. 1994 Mar;7(3):211-9 [8106963] J Virol. 1994 Aug;68(8):4821-8 [7518527] J Infect Dis. 1994 Nov;170(5):1141-7 [7963706] Science. 1994 Nov 11;266(5187):1024-7 [7973652] J Virol. 1995 Jan;69(1):101-9 [7527081] Nature. 1996 Sep 26;383(6598):350-4 [8848050] J Virol. 1997 May;71(5):3734-41 [9094648] J Virol. 1997 Sep;71(9):6869-74 [9261412] J Virol. 1998 May;72(5):3512-9 [9557629] Nature. 1998 Jun 18;393(6686):705-11 [9641684] J Virol. 1998 Dec;72(12):10270-4 [9811774] Immunity. 1999 Apr;10(4):431-8 [10229186] J Virol. 1999 Oct;73(10):8873-9 [10482646] J Virol. 2004 Dec;78(23):13232-52 [15542675] J Virol. 2005 May;79(10):6523-7 [15858036] J Virol. 2005 Aug;79(16):10108-25 [16051804] J Virol. 2006 Jan;80(2):835-44 [16378985] Annu Rev Immunol. 2006;24:739-69 [16551265] AIDS Res Hum Retroviruses. 2006 May;22(5):430-7 [16706620] J Virol. 2006 Oct;80(19):9586-98 [16973562] Expert Rev Vaccines. 2006 Aug;5(4):579-95 [16989638] J Virol. 2006 Dec;80(23):11776-90 [16971434] Vaccine. 2007 Feb 9;25(8):1398-408 [17113201] Curr Pharm Des. 2007;13(2):213-27 [17269929] Nature. 2007 Feb 15;445(7129):732-7 [17301785] J Virol. 2007 Jun;81(12):6548-62 [17409160] PLoS Pathog. 2007 Aug 24;3(8):e117 [17722977] Nat Med. 2007 Sep;13(9):1032-4 [17721546] Virology. 2007 Oct 10;367(1):222-34 [17599380] J Virol. 2001 Apr;75(7):3435-43 [11238869] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01142-09 ER - TY - JOUR T1 - The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling. AN - 733812008; 20049119 AB - Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. Because estrogen signaling is necessary for normal reproductive function and modulates gene expression, the estrogen-signaling pathway is a likely target for MAA; however, little is known about the effects of MAA in this regard. We evaluated the mechanistic effects of MAA on estrogen receptor (ER) expression and estrogen signaling using in vitro and in vivo model systems. MAA potentiates 17beta-estradiol (E(2)) stimulation of an estrogen-responsive reporter plasmid in HeLa cells transiently transfected with either a human ERalpha or ERbeta expression vector containing a cytomegalovirus (CMV) promoter. This result is attributed to increased exogenous ER expression due to MAA-mediated activation of the CMV promoter. In contrast to its effects on exogenous ER, MAA decreases endogenous ERalpha expression and attenuates E(2)-stimulated endogenous gene expression in both MCF-7 cells and the mouse uterus. These results illustrate the importance of careful experimental design and analysis when assessing the potential endocrine-disrupting properties of a compound to ensure biological responses are in concordance with in vitro analyses. Given the established role of the ER in normal reproductive function, the effects of MAA on the endogenous ER reported here are consistent with the reproductive abnormalities observed after EGME exposure and suggest that these toxicities may be due, at least in part, to attenuation of endogenous ER-mediated signaling. JF - Environmental health perspectives AU - Henley, Derek V AU - Mueller, Stephanie AU - Korach, Kenneth S AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1702 EP - 1706 VL - 117 IS - 11 KW - Acetates KW - 0 KW - Endocrine Disruptors KW - Estrogen Receptor alpha KW - Estrogen Receptor beta KW - Estradiol KW - 4TI98Z838E KW - methoxyacetic acid KW - F11T1H7Q7W KW - Index Medicus KW - estrogen KW - short-chain fatty acid KW - estrogen receptor KW - Animals KW - HeLa Cells KW - Humans KW - Estradiol -- pharmacology KW - Cell Line, Tumor KW - Mice KW - Research Design KW - Uterus -- drug effects KW - Uterus -- metabolism KW - Endocrine Disruptors -- toxicity KW - Promoter Regions, Genetic KW - Signal Transduction -- drug effects KW - Cytomegalovirus -- genetics KW - Mice, Inbred C57BL KW - Female KW - Estrogen Receptor alpha -- genetics KW - Estrogen Receptor alpha -- drug effects KW - Gene Expression Regulation -- drug effects KW - Estrogen Receptor beta -- drug effects KW - Acetates -- toxicity KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733812008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+short-chain+fatty+acid+methoxyacetic+acid+disrupts+endogenous+estrogen+receptor-alpha-mediated+signaling.&rft.au=Henley%2C+Derek+V%3BMueller%2C+Stephanie%3BKorach%2C+Kenneth+S&rft.aulast=Henley&rft.aufirst=Derek&rft.date=2009-11-01&rft.volume=117&rft.issue=11&rft.spage=1702&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900800 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-26 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1983 Nov 11;11(21):7631-48 [6316266] Toxicol Appl Pharmacol. 1983 Feb;67(2):229-37 [6836577] Environ Health Perspect. 1984 Aug;57:207-17 [6499806] Breast Cancer Res Treat. 1984;4(4):269-74 [6518293] Am J Ind Med. 1988;14(5):509-26 [3228067] N Engl J Med. 1993 Nov 4;329(19):1383-8 [8413434] Am J Epidemiol. 1996 Apr 1;143(7):707-17 [8651233] Biochem Biophys Res Commun. 1996 Jul 25;224(3):796-801 [8713125] Toxicol Appl Pharmacol. 1997 Feb;142(2):328-37 [9070356] Virology. 1997 May 12;231(2):201-9 [9168882] Brain Res Mol Brain Res. 1999 Jan 22;64(1):52-8 [9889318] Endocrinology. 2004 Dec;145(12):5485-92 [15345672] Toxicol Lett. 2005 Mar 28;156(1):13-28 [15705484] Annu Rev Physiol. 2005;67:285-308 [15709960] Mol Endocrinol. 2005 Apr;19(4):833-42 [15695368] Cancer Lett. 2005 Jul 28;225(2):199-206 [15978324] Oncogene. 2005 Jul 21;24(31):4894-907 [15870696] Cell Death Differ. 2006 Mar;13(3):446-53 [16167071] Epilepsy Behav. 2007 Feb;10(1):77-83 [17098479] Endocr Relat Cancer. 2007 Dec;14(4):1021-8 [18045953] Toxicol Appl Pharmacol. 2009 Jul 15;238(2):101-10 [18486176] Toxicol Appl Pharmacol. 2000 May 15;165(1):53-62 [10814553] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] J Clin Psychiatry. 2002 Apr;63(4):322-30 [12000206] Am J Hematol. 2002 Sep;71(1):45-6 [12221674] Mol Cell Endocrinol. 2004 Jan 15;213(2):173-9 [15062565] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204 [15103026] Steroids. 1971 Aug;18(2):219-29 [5126820] J Biol Chem. 1978 May 25;253(10):3364-6 [649576] Cell. 1978 May;14(1):115-21 [667928] Biochem Biophys Res Commun. 1984 Feb 29;119(1):132-8 [6704117] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900800 ER - TY - JOUR T1 - Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. AN - 733714684; 19638958 AB - Insertional mutagenesis leading to insurgence of leukemia has been shown as a consequence of retroviral (RV)-mediated gene transfer in animal models and in clinical trials of gene therapy for X-linked severe combined immunodeficiency. Aberrant expression of oncogenes neighboring the gamma-RV vector insertion site via induction by the enhancer element of the viral long terminal repeats (LTRs) is thought to have played a role in leukemogenesis. Consequently, RV vectors devoid of LTR enhancer elements could prove as safer tools for gene transfer. To test this hypothesis, we evaluated the immortalization ability of two RV vectors: one carrying the full-length Moloney leukemia virus (MLV) LTR and one with the same LTR in which the enhancer element was deleted [MLV self-inactivating (SIN)]. Unexpectedly, transduction with MLV SIN resulted in an only slightly and not significant decreased immortalization frequency of primary bone marrow (BM) cultures (about 37%) compared to transduction with MLV (about 48%). Similar to MLV, immortalization by MLV SIN is likely caused by insertional activation of oncogenes including Evi1, Mds1, Mef2c, and Hoxa7. Our results indicate that the MLV SIN, devoid of the LTR enhancer element, was still able to immortalize BM cells by activating nearby gene expression, indicating the need of an accurate selection of the internal promoter to obtain safer SIN RV vectors. JF - Molecular therapy : the journal of the American Society of Gene Therapy AU - Bosticardo, Marita AU - Ghosh, Amrita AU - Du, Yang AU - Jenkins, Nancy A AU - Copeland, Neal G AU - Candotti, Fabio AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1910 EP - 1918 VL - 17 IS - 11 KW - Index Medicus KW - Animals KW - Terminal Repeat Sequences -- genetics KW - Genetic Therapy -- adverse effects KW - Cells, Cultured KW - Genetic Therapy -- methods KW - Terminal Repeat Sequences -- physiology KW - Promoter Regions, Genetic -- genetics KW - Moloney murine leukemia virus -- genetics KW - Mice KW - Virus Integration -- genetics KW - Mutagenesis, Insertional KW - Bone Marrow Cells -- metabolism KW - Genetic Vectors -- genetics KW - Bone Marrow Cells -- cytology KW - Retroviridae -- genetics KW - Transduction, Genetic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733714684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.atitle=Self-inactivating+retroviral+vector-mediated+gene+transfer+induces+oncogene+activation+and+immortalization+of+primary+murine+bone+marrow+cells.&rft.au=Bosticardo%2C+Marita%3BGhosh%2C+Amrita%3BDu%2C+Yang%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G%3BCandotti%2C+Fabio&rft.aulast=Bosticardo&rft.aufirst=Marita&rft.date=2009-11-01&rft.volume=17&rft.issue=11&rft.spage=1910&rft.isbn=&rft.btitle=&rft.title=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.issn=1525-0024&rft_id=info:doi/10.1038%2Fmt.2009.172 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-10-30 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: Mol Ther. 2009 Jan;17(1):131-43 [19002163] J Clin Invest. 2008 Sep;118(9):3143-50 [18688286] Biotechniques. 2000 Apr;28(4):702-8 [10769748] Mol Ther. 2000 Feb;1(2):145-53 [10933924] Genesis. 2001 Aug;30(4):259-63 [11536432] Science. 2002 Apr 19;296(5567):497 [11964471] Nat Genet. 2002 Sep;32(1):166-74 [12185365] N Engl J Med. 2003 Jan 16;348(3):255-6 [12529469] Science. 2003 Jun 13;300(5626):1749-51 [12805549] Blood Cells Mol Dis. 2003 Sep-Oct;31(2):206-12 [12972028] Science. 2003 Oct 17;302(5644):415-9 [14564000] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7 [14681473] J Biol Chem. 2004 Apr 23;279(17):17772-84 [14754893] Gene Ther. 2004 Nov;11(21):1568-78 [15372067] Genomics. 2004 Sep;84(3):592-5 [15498466] Proc Natl Acad Sci U S A. 1986 May;83(10):3194-8 [3458176] Nucleic Acids Res. 1991 Oct 25;19(20):5755-61 [1945853] Hum Gene Ther. 1992 Oct;3(5):479-86 [1420447] Growth Factors. 1993;8(3):197-209 [8391284] Nature. 2004 Dec 2;432(7017):635-9 [15577913] Blood. 2005 Jun 1;105(11):4235-46 [15713797] Science. 2005 May 20;308(5725):1171-4 [15905401] Blood. 2005 Oct 1;106(7):2530-3 [15933056] Blood. 2005 Oct 1;106(7):2498-505 [15961513] Blood. 2005 Dec 1;106(12):3932-9 [16109773] Nat Med. 2006 Apr;12(4):401-9 [16582916] Nat Biotechnol. 2006 Jun;24(6):687-96 [16732270] Blood. 2006 Oct 15;108(8):2545-53 [16825499] Curr Opin Hematol. 2007 Mar;14(2):85-9 [17255784] Mol Ther. 2008 Apr;16(4):718-25 [18334985] J Clin Invest. 2008 Sep;118(9):3132-42 [18688285] J Clin Invest. 2009 Apr;119(4):964-75 [19307726] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1038/mt.2009.172 ER - TY - JOUR T1 - Photochemical reactions involved in the phototoxicity of the anticonvulsant and antidepressant drug lamotrigine (Lamictal). AN - 733616148; 19659919 AB - Lamotrigine (LTG) [3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine], an anticonvulsant and antidepressant drug Lamictal, produces a (photo)toxic response in some patients. LTG absorbs UV light, generating singlet oxygen (1O2) with a quantum yield of 0.22 in CH2Cl2, 0.11 in MeCN and 0.01 in D2O. A small production of superoxide radical anion was also detected in acetonitrile. Thus, LTG is a moderate photosensitizer producing phototoxicity and oxidizing linoleic acid. LTG is a weak 1O2 quencher (k(q) = 3.2 x 10(5) M(-1) s(-1) in MeCN), but its photodecomposition products in dimethyl sulfoxide (DMSO) quenched 1O2 very efficiently. Upon intense UV irradiation from a xenon lamp, LTG was photobleached rapidly in DMSO and slowly in acetonitrile, alcohol and water. The rate increased significantly when laser pulses at 266 nm were employed. The photobleaching products generated 1O2 twice as strongly as LTG. Photobleaching was usually accompanied by the release of chloride anions, which increased in the presence of ascorbic acid. This suggests the formation of aryl radicals via dechlorination, a process which may be responsible for the photoallergic response observed in some patients. Our results demonstrate that LTG is a moderate generator of 1O2 prone to photodechlorination, especially in a reducing environment, which can contribute to the reported phototoxicity of LTG. JF - Photochemistry and photobiology AU - Bilski, Piotr J AU - Wolak, M A AU - Zhang, V AU - Moore, D E AU - Chignell, C F AD - Laboratory of Pharmacology, NIEHS, RTP, NC, USA. Bilski@niehs.nih.gov PY - 2009 SP - 1327 EP - 1335 VL - 85 IS - 6 KW - Anticonvulsants KW - 0 KW - Antidepressive Agents KW - Photosensitizing Agents KW - Triazines KW - Singlet Oxygen KW - 17778-80-2 KW - lamotrigine KW - U3H27498KS KW - Index Medicus KW - Photochemistry KW - Spectrum Analysis KW - Humans KW - Anticonvulsants -- chemistry KW - Triazines -- toxicity KW - Photosensitizing Agents -- chemistry KW - Antidepressive Agents -- chemistry KW - Anticonvulsants -- toxicity KW - Dermatitis, Phototoxic KW - Triazines -- adverse effects KW - Antidepressive Agents -- toxicity KW - Triazines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733616148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Photochemical+reactions+involved+in+the+phototoxicity+of+the+anticonvulsant+and+antidepressant+drug+lamotrigine+%28Lamictal%29.&rft.au=Bilski%2C+Piotr+J%3BWolak%2C+M+A%3BZhang%2C+V%3BMoore%2C+D+E%3BChignell%2C+C+F&rft.aulast=Bilski&rft.aufirst=Piotr&rft.date=2009-11-01&rft.volume=85&rft.issue=6&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=1751-1097&rft_id=info:doi/10.1111%2Fj.1751-1097.2009.00590.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-29 N1 - Date created - 2009-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1751-1097.2009.00590.x ER - TY - JOUR T1 - The pathology of drug-induced liver injury. AN - 733605326; 19826970 AB - The liver biopsy is frequently used as an adjunct diagnostic test in the evaluation of drug-induced liver injury (DILI). A biopsy may be performed to confirm the diagnosis, especially when there is a complex clinical differential diagnosis that includes DILI. A biopsy can also be used to stage the severity of hepatotoxicity so that a necessary agent may be continued. Alternatively, a drug or toxin may only be implicated after a biopsy is performed, particularly in the case of subacute or chronic liver injury. The pathologist should approach the biopsy systematically by first classifying the disease and then working with the clinician to include or exclude etiologies in the pathological differential diagnosis. This article outlines a practical approach to the diagnosis of DILI on liver biopsy, including the common patterns of injury observed in drug- and toxin-induced liver pathology and prognostic pathological features that may be associated with the outcome of patients with DILI. JF - Seminars in liver disease AU - Kleiner, David E AD - Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA. kleinerd@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 364 EP - 372 VL - 29 IS - 4 KW - Index Medicus KW - Severity of Illness Index KW - Necrosis KW - Diagnosis, Differential KW - Granuloma -- pathology KW - Cholestasis -- pathology KW - Risk Factors KW - Humans KW - Prognosis KW - Predictive Value of Tests KW - Fatty Liver -- pathology KW - Biopsy KW - Cytoplasm -- pathology KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- etiology KW - Drug-Induced Liver Injury, Chronic -- pathology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Drug-Induced Liver Injury, Chronic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733605326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=The+pathology+of+drug-induced+liver+injury.&rft.au=Kleiner%2C+David+E&rft.aulast=Kleiner&rft.aufirst=David&rft.date=2009-11-01&rft.volume=29&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=1098-8971&rft_id=info:doi/10.1055%2Fs-0029-1240005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-17 N1 - Date created - 2009-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0029-1240005 ER - TY - JOUR T1 - Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat. AN - 733131575; 19679675 AB - Based on animal data, there is speculation that (+ or -)-3,4-methylenedioxymethamphetamine (MDMA) is neurotoxic to humans. Extrapolation of MDMA findings from animals to humans requires assessment of pharmacokinetics in various species, and low-dose administration data from rats are lacking. In this study, we examine MDMA pharmacokinetics in rats given low (2 mg/kg) and high (10 mg/kg) doses of racemic MDMA via intraperitoneal, subcutaneous, and oral routes. Repeated blood specimens were collected from venous catheters, and plasma was assayed for MDMA and its metabolites, 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA), by gas chromatography-mass spectrometry. After 2 mg/kg, maximum MDMA concentrations (C(max)) were approximately 200 ng/ml for intraperitoneal and subcutaneous routes, but less for the oral route. MDMA plasma half-lives were 2 h. After 10 mg/kg, MDMA areas under the curve (AUCs) were 21-fold (intraperitoneal), 10-fold (subcutaneous), and 36-fold (oral) greater than those at 2 mg/kg. In contrast, HMMA AUC values in high-dose groups were <3-fold above those at 2 mg/kg. Several new findings emerge from this report of low-dose MDMA pharmacokinetics in rats. First, 2 mg/kg MDMA in rats can produce MDMA C(max) values similar to those in humans, perhaps explaining why both species discriminate 1.5 mg/kg MDMA in laboratory paradigms. Second, our data provide additional support for nonlinear kinetics of MDMA in rats, and, analogous to humans, this phenomenon appears to involve impaired drug metabolism. Finally, given key similarities between MDMA pharmacokinetics in rats and humans, data from rats may be clinically relevant when appropriate dosing conditions are used. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Baumann, Michael H AU - Zolkowska, Dorota AU - Kim, Insook AU - Scheidweiler, Karl B AU - Rothman, Richard B AU - Huestis, Marilyn A AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Dr., Suite 4500, Baltimore, MD 21224, USA. mbaumann@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 2163 EP - 2170 VL - 37 IS - 11 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Tissue Distribution -- physiology KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Metabolic Clearance Rate -- physiology KW - Metabolic Clearance Rate -- drug effects KW - Tissue Distribution -- drug effects KW - Male KW - Drug Administration Routes KW - N-Methyl-3,4-methylenedioxyamphetamine -- analogs & derivatives KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacokinetics KW - N-Methyl-3,4-methylenedioxyamphetamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733131575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Effects+of+dose+and+route+of+administration+on+pharmacokinetics+of+%28%2B+or+-%29-3%2C4-methylenedioxymethamphetamine+in+the+rat.&rft.au=Baumann%2C+Michael+H%3BZolkowska%2C+Dorota%3BKim%2C+Insook%3BScheidweiler%2C+Karl+B%3BRothman%2C+Richard+B%3BHuestis%2C+Marilyn+A&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-11-01&rft.volume=37&rft.issue=11&rft.spage=2163&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.109.028506 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-03 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 2006 Jan 4;81(1):27-36 [15975736] Ther Drug Monit. 2009 Jun;31(3):367-73 [19417716] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] J Anal Toxicol. 2007 Apr;31(3):138-43 [17579960] Drug Metab Dispos. 2007 Oct;35(10):1840-5 [17640955] Br J Clin Pharmacol. 2000 Feb;49(2):104-9 [10671903] Toxicol Lett. 2000 Mar 15;112-113:133-42 [10720722] Neuropsychobiology. 2000;42(1):5-10 [10867550] Chem Res Toxicol. 2001 Sep;14(9):1203-8 [11559034] Addiction. 2002 Dec;97(12):1531-6 [12472637] Mol Pharmacol. 2003 Jun;63(6):1223-9 [12761331] Pharmacol Rev. 2003 Sep;55(3):463-508 [12869661] Ther Drug Monit. 2004 Apr;26(2):132-6 [15228153] Ther Drug Monit. 2004 Apr;26(2):137-44 [15228154] Trends Pharmacol Sci. 2004 Oct;25(10):505-8 [15380932] Life Sci. 1986 Oct 20;39(16):1457-64 [2877380] Eur J Pharmacol. 1986 Dec 16;132(2-3):269-76 [2880735] Pharmacol Biochem Behav. 1988 Dec;31(4):817-24 [2908067] Neurotoxicology. 1989 Fall;10(3):529-42 [2576304] Eur J Pharmacol. 1991 Jul 23;200(1):9-16 [1685125] J Pharm Biomed Anal. 1992 Sep;10(9):657-65 [1363061] Mol Pharmacol. 1994 Feb;45(2):359-65 [7906857] Biochem Pharmacol. 1994 Mar 29;47(7):1151-6 [7909223] Biochem Pharmacol. 1996 Mar 22;51(6):789-96 [8602874] Biochem Pharmacol. 1997 Jun 1;53(11):1605-12 [9264312] J Pharmacol Exp Ther. 1999 Jul;290(1):136-45 [10381769] J Psychopharmacol. 2005 Jan;19(1):71-83 [15671132] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] J Pharm Sci. 2008 Apr;97(4):1593-605 [17724664] Psychopharmacology (Berl). 2008 Apr;197(2):263-78 [18074122] Neuroscience. 2008 Mar 27;152(3):773-84 [18313226] Ther Drug Monit. 2008 Jun;30(3):320-32 [18520604] J Clin Psychopharmacol. 2008 Aug;28(4):432-40 [18626271] J Pharmacol Exp Ther. 2008 Oct;327(1):38-44 [18591215] Ann N Y Acad Sci. 2008 Oct;1139:151-63 [18991859] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Dec 15;876(2):266-76 [19026602] Psychopharmacology (Berl). 2009 Jun;204(2):375-8 [19139850] Psychopharmacology (Berl). 2007 Jan;189(4):489-503 [16220332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.109.028506 ER - TY - JOUR T1 - Microbial load from animal feces at a recreational beach. AN - 67697281; 19664785 AB - The goal of this study was to quantify the microbial load (enterococci) contributed by the different animals that frequent a beach site. The highest enterococci concentrations were observed in dog feces with average levels of 3.9 x 10(7) CFU/g; the next highest enterococci levels were observed in birds averaging 3.3 x 10(5)CFU/g. The lowest measured levels of enterococci were observed in material collected from shrimp fecal mounds (2.0 CFU/g). A comparison of the microbial loads showed that 1 dog fecal event was equivalent to 6940 bird fecal events or 3.2 x 10(8) shrimp fecal mounds. Comparing animal contributions to previously published numbers for human bather shedding indicates that one adult human swimmer contributes approximately the same microbial load as one bird fecal event. Given the abundance of animals observed on the beach, this study suggests that dogs are the largest contributing animal source of enterococci to the beach site. JF - Marine pollution bulletin AU - Wright, Mary E AU - Solo-Gabriele, Helena M AU - Elmir, Samir AU - Fleming, Lora E AD - National Science Foundation-National Institute of Environmental Health Sciences Oceans and Human Health Center, University of Miami Rosenstiel School of Marine and Atmospheric Science, 1801 NW 9th Avenue, Suite 200 (R-669), Miami, Florida 33136, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1649 EP - 1656 VL - 58 IS - 11 KW - Index Medicus KW - Environmental Monitoring KW - Animals KW - Penaeidae KW - Dogs KW - Colony Count, Microbial KW - Birds KW - Feces -- microbiology KW - Bathing Beaches KW - Enterococcus -- isolation & purification KW - Geologic Sediments -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67697281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+pollution+bulletin&rft.atitle=Microbial+load+from+animal+feces+at+a+recreational+beach.&rft.au=Wright%2C+Mary+E%3BSolo-Gabriele%2C+Helena+M%3BElmir%2C+Samir%3BFleming%2C+Lora+E&rft.aulast=Wright&rft.aufirst=Mary&rft.date=2009-11-01&rft.volume=58&rft.issue=11&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Marine+pollution+bulletin&rft.issn=1879-3363&rft_id=info:doi/10.1016%2Fj.marpolbul.2009.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Environ Microbiol. 1999 Dec;65(12):5628-30 [10584032] J Appl Microbiol. 1998 Dec;85 Suppl 1:101S-107S [21182698] J Vet Med B Infect Dis Vet Public Health. 2002 Aug;49(6):278-80 [12241027] J Parasitol. 2002 Dec;88(6):1254-8 [12537124] J Appl Microbiol. 2003;94(5):865-78 [12694452] Environ Sci Technol. 2003 Aug 1;37(15):3275-82 [12966970] Int J Food Microbiol. 2003 Dec 1;88(2-3):133-45 [14596986] J Anim Sci. 2004 Apr;82(4):1122-35 [15080335] Water Res. 2004 Jul;38(13):3119-31 [15261551] Appl Environ Microbiol. 1993 Apr;59(4):1228-30 [8489231] Appl Environ Microbiol. 1995 May;61(5):1888-96 [7646026] J Anim Sci. 1997 Sep;75(9):2497-505 [9303468] Appl Environ Microbiol. 1998 Jul;64(7):2736-8 [9647860] Appl Environ Microbiol. 1998 Dec;64(12):5027-9 [9835602] Appl Environ Microbiol. 1999 Feb;65(2):865-7 [9925633] Water Sci Technol. 2005;51(3-4):199-207 [15850191] J Appl Microbiol. 2005;99(2):348-53 [16033466] Water Res. 2005 Sep;39(15):3565-78 [16095656] Appl Environ Microbiol. 2005 Oct;71(10):5929-34 [16204506] Microb Drug Resist. 2005 Winter;11(4):395-403 [16359201] J Environ Qual. 2006 Jul-Aug;35(4):1088-100 [16738394] Water Res. 2007 Jan;41(1):3-10 [17113123] Int J Antimicrob Agents. 2007 Jul;30(1):98-100 [17509838] Water Res. 2007 Aug;41(16):3585-94 [17575998] Mar Pollut Bull. 2007 Sep;54(9):1472-82 [17610908] Environ Sci Technol. 2001 Jun 15;35(12):2407-16 [11432541] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.marpolbul.2009.07.003 ER - TY - JOUR T1 - Molecular basis of binding of the Plasmodium falciparum receptor BAEBL to erythrocyte receptor glycophorin C. AN - 67593311; 19563830 AB - Plasmodium falciparum invades human erythrocytes by redundant pathways. Unlike Plasmodium vivax that has one Duffy Binding-Like (DBL) receptor, P. falciparum has four members of the DBL receptor family. Furthermore, one of these DBL genes, BAEBL, has polymorphisms at four amino acids in region II; each polymorphism binds to a different erythrocyte receptor. One BAEBL variant (VSTK) binds specifically to erythrocyte glycophorin C and binds poorly to neuraminidase-treated erythrocytes. When the amino acid threonine (T121) in BAEBL (VSTK) is changed to a lysine (VSKK), it no longer requires sialic acid as a receptor. To explore the molecular basis of sialic acid binding, we modeled the structure of region II of BAEBL (VSTK) on the crystal structure of a related DBL receptor, region II of erythrocyte binding antigen-175 (EBA-175). Four charged amino acids, R52, R114, E54 and D125, are predicted to surround T121 in BAEBL (VSTK). They were individually mutated to alanine (R52A, R114A, E54A, and D125A) or lysine (R52K, R114K) and expressed on the surface of Chinese hamster ovary (CHO-K1) cells. BAEBL (VSTK) with mutations in R52 or R114 of BAEBL (VSTK) bound neuraminidase-treated erythrocytes. Unlike the arginine mutations, E54A and D125A still bound poorly to neuraminidase-treated erythrocytes. These findings suggest that the two arginine residues surrounding T121 are critical for the binding specificity of BAEBL (VSTK) to sialic acid and suggest a role for arginine in sialic acid binding independent of its negative charge. JF - Molecular and biochemical parasitology AU - Jiang, Lubin AU - Duriseti, Sai AU - Sun, Peter AU - Miller, Louis H AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Bethesda, MD 20892-8132, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 49 EP - 54 VL - 168 IS - 1 KW - Carrier Proteins KW - 0 KW - Glycophorin KW - Protozoan Proteins KW - erythrocyte binding protein-2, Plasmodium falciparum KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Computer Simulation KW - Cricetulus KW - Models, Molecular KW - Amino Acid Substitution -- genetics KW - Humans KW - CHO Cells KW - Protein Binding KW - Cricetinae KW - Erythrocytes -- parasitology KW - Protozoan Proteins -- metabolism KW - Carrier Proteins -- metabolism KW - Plasmodium falciparum -- genetics KW - Carrier Proteins -- genetics KW - Protozoan Proteins -- genetics KW - Glycophorin -- metabolism KW - Plasmodium falciparum -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67593311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+biochemical+parasitology&rft.atitle=Molecular+basis+of+binding+of+the+Plasmodium+falciparum+receptor+BAEBL+to+erythrocyte+receptor+glycophorin+C.&rft.au=Jiang%2C+Lubin%3BDuriseti%2C+Sai%3BSun%2C+Peter%3BMiller%2C+Louis+H&rft.aulast=Jiang&rft.aufirst=Lubin&rft.date=2009-11-01&rft.volume=168&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Molecular+and+biochemical+parasitology&rft.issn=1872-9428&rft_id=info:doi/10.1016%2Fj.molbiopara.2009.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-16 N1 - Date created - 2009-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13973-7 [10570183] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2358-62 [16461900] Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):272-7 [14694201] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2518-23 [14983041] Transfusion. 1972 May-Jun;12(3):145-56 [5026166] N Engl J Med. 1976 Aug 5;295(6):302-4 [778616] J Cell Biol. 1978 Apr;77(1):72-82 [96121] Hum Hered. 1982;32(6):385-403 [6218066] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7085-9 [1496004] Biochemistry. 1992 Oct 13;31(40):9609-21 [1327122] Proteins. 1992 Nov;14(3):327-32 [1438172] Immunol Cell Biol. 1994 Feb;72(1):23-7 [8157284] Science. 1994 Jun 24;264(5167):1941-4 [8009226] J Exp Med. 1994 Aug 1;180(2):497-506 [8046329] Nat Genet. 1995 Jun;10(2):224-8 [7663520] Mol Cell. 1998 Apr;1(5):719-28 [9660955] Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5552-7 [15805191] Cell. 2005 Jul 29;122(2):183-93 [16051144] J Exp Med. 2002 Dec 2;196(11):1523-8 [12461087] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molbiopara.2009.06.006 ER - TY - JOUR T1 - Risk of cataract extraction among adult retinoblastoma survivors. AN - 66637295; 19901216 AB - To investigate the risk of cataract extraction among adult retinoblastoma survivors. A retrospective cohort study was performed on retinoblastoma survivors who received the diagnosis from 1914 to 1984 and were interviewed in 2000. Lens doses were estimated from radiotherapy records. The cumulative time interval to cataract extraction between dose groups was compared using the log-rank test and Cox regression. Seven hundred fifty-three subjects (828 eyes) were available for analysis for an average of 32 years of follow-up. During this period, 51 cataract extractions were reported. One extraction was reported in an eye with no radiotherapy compared with 36 extractions in 306 eyes with 1 course of radiotherapy and 14 among 38 eyes with 2 or 3 treatments. The average time interval to cataract extraction in irradiated eyes was 51 years (95% confidence interval [CI], 48-54) following 1 treatment and 32 years (95% CI, 27-37) after 2 or 3 treatments. Eyes exposed to a therapeutic radiation dose of 5 Gy or more had a 6-fold increased risk (95% CI, 1.3-27.2) of cataract extraction compared with eyes exposed to 2.5 Gy or less. The results emphasize the importance of ophthalmologic examination of retinoblastoma survivors who have undergone radiotherapy. The risk of cataract extraction in untreated eyes with retinoblastoma is comparable with the risk of the general population. JF - Archives of ophthalmology (Chicago, Ill. : 1960) AU - Chodick, Gabriel AU - Kleinerman, Ruth A AU - Stovall, Marilyn AU - Abramson, David H AU - Seddon, Johanna M AU - Smith, Susan A AU - Tucker, Margaret A AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7238, USA. hodik_g@mac.org.il Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1500 EP - 1504 VL - 127 IS - 11 KW - Cobalt Radioisotopes KW - 0 KW - Radon KW - Q74S4N8N1G KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Radiation Dosage KW - Humans KW - Retrospective Studies KW - Aged KW - Cobalt Radioisotopes -- adverse effects KW - Radon -- adverse effects KW - Risk Factors KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Survivors KW - Female KW - Male KW - Radiation Injuries KW - Radiation, Ionizing KW - Retinoblastoma -- mortality KW - Retinal Neoplasms -- mortality KW - Cataract Extraction -- statistics & numerical data KW - Retinal Neoplasms -- pathology KW - Brachytherapy -- adverse effects KW - Retinal Neoplasms -- radiotherapy KW - Cataract -- prevention & control KW - Retinoblastoma -- radiotherapy KW - Lens, Crystalline -- radiation effects KW - Cataract -- etiology KW - Retinoblastoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66637295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Risk+of+cataract+extraction+among+adult+retinoblastoma+survivors.&rft.au=Chodick%2C+Gabriel%3BKleinerman%2C+Ruth+A%3BStovall%2C+Marilyn%3BAbramson%2C+David+H%3BSeddon%2C+Johanna+M%3BSmith%2C+Susan+A%3BTucker%2C+Margaret+A&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2009-11-01&rft.volume=127&rft.issue=11&rft.spage=1500&rft.isbn=&rft.btitle=&rft.title=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=1538-3601&rft_id=info:doi/10.1001%2Farchophthalmol.2009.271 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indian Pediatr. 2001 Jan;38(1):15-23 [11175929] Ophthalmology. 2007 Jul;114(7):1363-71 [17337065] Am J Hum Genet. 2003 Feb;72(2):253-69 [12541220] Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2905-8 [12824230] Australas Radiol. 2003 Sep;47(3):226-30 [12890239] Clin Experiment Ophthalmol. 2003 Oct;31(5):392-6 [14516425] Radiology. 1975 Mar;114(3):705-8 [804172] Am J Epidemiol. 1977 Jul;106(1):33-41 [141882] Arch Ophthalmol. 1978 Oct;96(10):1826-30 [697618] Am J Epidemiol. 1983 Aug;118(2):239-49 [6881129] Am J Ophthalmol. 1983 Sep;96(3):304-10 [6614109] Radiother Oncol. 1985 Feb;3(2):117-32 [3920733] Nature. 1986 Oct 16-22;323(6089):643-6 [2877398] Int J Radiat Oncol Biol Phys. 1988 Aug;15(2):455-60 [3403326] Cancer. 1990 Jul 1;66(1):21-6 [2354405] Arch Ophthalmol. 1990 Dec;108(12):1701-8 [2256840] Surv Ophthalmol. 1995 Jan-Feb;39(4):323-34 [7725232] Med Pediatr Oncol. 1996 May;26(5):297-304 [8614362] Int J Radiat Oncol Biol Phys. 1996 Apr 1;35(1):45-51 [8641925] Epidemiol Rev. 1995;17(2):336-46 [8654515] Ophthalmology. 1997 Apr;104(4):573-80 [9111248] Eur J Ophthalmol. 1998 Apr-Jun;8(2):106-11 [9673480] Radiat Res. 1999 Aug;152(2):190-5 [10409329] J Clin Oncol. 2005 Apr 1;23(10):2272-9 [15800318] Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1424-31 [16427213] J AAPOS. 2002 Apr;6(2):108-11 [11997807] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archophthalmol.2009.271 ER - TY - JOUR T1 - Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. AN - 66637093; 19765194 AB - Neuroprotective properties of the mood stabilizer valproic acid (VPA) are implicated in its therapeutic efficacy. Heat-shock protein 70 (HSP70) is a molecular chaperone, neuroprotective and anti-inflammatory agent. This study aimed to investigate underlying mechanisms and functional significance of HSP70 induction by VPA in rat cortical neurons. VPA treatment markedly up-regulated HSP70 protein levels, and this was accompanied by increased HSP70 mRNA levels and promoter hyperacetylation and activity. Other HDAC inhibitors--sodium butyrate, trichostatin A, and Class I HDAC-specific inhibitors MS-275 and apicidin, --all mimicked the ability of VPA to induce HSP70. Pre-treatment with phosphatidylinositol 3-kinase inhibitors or an Akt inhibitor attenuated HSP70 induction by VPA and other HDAC inhibitors. VPA treatment increased Sp1 acetylation, and a Sp1 inhibitor, mithramycin, abolished the induction of HSP70 by HDAC inhibitors. Moreover, VPA promoted the association of Sp1 with the histone acetyltransferases p300 and recruitment of p300 to the HSP70 promoter. Further, VPA-induced neuroprotection against glutamate excitotoxicity was prevented by blocking HSP70 induction. Taken together, the data suggest that the phosphatidylinositol 3-kinase/Akt pathway and Sp1 are likely involved in HSP70 induction by HDAC inhibitors, and induction of HSP70 by VPA in cortical neurons may contribute to its neuroprotective and therapeutic effects. JF - Journal of neurochemistry AU - Marinova, Zoya AU - Ren, Ming AU - Wendland, Jens R AU - Leng, Yan AU - Liang, Min-Huei AU - Yasuda, Shigeru AU - Leeds, Peter AU - Chuang, De-Maw AD - Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1363, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 976 EP - 987 VL - 111 IS - 4 KW - Enzyme Inhibitors KW - 0 KW - HSP70 Heat-Shock Proteins KW - Immunoglobulins KW - SP1 antigen KW - Tetrazolium Salts KW - Thiazoles KW - Valproic Acid KW - 614OI1Z5WI KW - Hdac1 protein, rat KW - EC 3.5.1.98 KW - Histone Deacetylase 1 KW - Histone Deacetylases KW - thiazolyl blue KW - EUY85H477I KW - dipropylacetamide KW - RUA6CWU76G KW - Index Medicus KW - Animals KW - Acetylation -- drug effects KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Rats KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Chromatin Immunoprecipitation -- methods KW - Time Factors KW - Embryo, Mammalian KW - Valproic Acid -- pharmacology KW - Valproic Acid -- analogs & derivatives KW - HSP70 Heat-Shock Proteins -- metabolism KW - Cerebral Cortex -- cytology KW - Neurons -- drug effects KW - Immunoglobulins -- metabolism KW - Histone Deacetylases -- metabolism KW - Enzyme Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66637093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Valproic+acid+induces+functional+heat-shock+protein+70+via+Class+I+histone+deacetylase+inhibition+in+cortical+neurons%3A+a+potential+role+of+Sp1+acetylation.&rft.au=Marinova%2C+Zoya%3BRen%2C+Ming%3BWendland%2C+Jens+R%3BLeng%2C+Yan%3BLiang%2C+Min-Huei%3BYasuda%2C+Shigeru%3BLeeds%2C+Peter%3BChuang%2C+De-Maw&rft.aulast=Marinova&rft.aufirst=Zoya&rft.date=2009-11-01&rft.volume=111&rft.issue=4&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2009.06385.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-06 N1 - Date created - 2009-10-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Res. 2000 Jun 1;60(11):2942-8 [10850441] Neurobiol Dis. 2008 Jun;30(3):303-11 [18378158] J Biol Chem. 2000 Sep 15;275(37):29147-52 [10856293] J Neurochem. 2000 Dec;75(6):2401-8 [11080191] FASEB J. 2001 May;15(7):1118-31 [11344080] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] J Cereb Blood Flow Metab. 2001 Nov;21(11):1303-9 [11702045] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] J Neurochem. 2002 Feb;80(4):589-97 [11841566] J Psychiatry Neurosci. 2002 Jul;27(4):260-5 [12174735] Ann Neurol. 2002 Aug;52(2):160-7 [12210785] Nature. 2002 Sep 26;419(6905):407-11 [12353038] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Neuropharmacology. 2002 Dec;43(7):1158-64 [12504922] Biochim Biophys Acta. 2003 Jan 3;1625(1):77-87 [12527428] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4281-6 [12640146] Proc Natl Acad Sci U S A. 2003 May 13;100(10):6210-5 [12732732] J Neurosci. 2003 Jul 2;23(13):5789-98 [12843283] J Neurosci. 2004 Feb 18;24(7):1700-6 [14973234] J Biol Chem. 2004 Apr 2;279(14):13506-13 [14726529] Hum Mol Genet. 2004 Jul 1;13(13):1389-405 [15115766] J Neurochem. 2004 Jun;89(6):1358-67 [15189338] Pharmacogenomics J. 2004;4(5):336-44 [15289798] Mol Biol Cell. 2004 Nov;15(11):4841-53 [15342781] Proc Natl Acad Sci U S A. 1982 May;79(10):3218-22 [6954473] Mol Cell Biol. 1987 Oct;7(10):3646-55 [2824993] Mol Cell Biol. 1989 Sep;9(9):4099-104 [2674689] Neuron. 1991 Dec;7(6):1043-51 [1722411] Endocrinology. 1993 Apr;132(4):1421-30 [8384986] Mol Cell Biol. 1995 Aug;15(8):4319-30 [7623826] J Neurosci. 1996 Jan 15;16(2):478-85 [8551332] Exp Cell Res. 1996 Aug 25;227(1):160-4 [8806463] J Biol Chem. 1997 Jul 18;272(29):18033-7 [9218432] Cell Stress Chaperones. 1997 Jun;2(2):132-9 [9250404] Nat Biotechnol. 1998 Sep;16(9):833-8 [9743115] Cancer Res. 2005 Feb 1;65(3):758-66 [15705872] J Biol Chem. 2005 Mar 18;280(11):10047-54 [15647279] BMC Biol. 2004;2:23 [15522123] Neuropsychobiology. 2005;51(2):107-14 [15741752] Ann N Y Acad Sci. 2005 Aug;1053:74-83 [16179510] Ann N Y Acad Sci. 2005 Aug;1053:195-204 [16179524] Mol Neurobiol. 2005 Oct;32(2):173-202 [16215281] J Biol Chem. 2005 Dec 2;280(48):39962-9 [16210323] FEBS Lett. 2005 Dec 19;579(30):6716-20 [16313906] J Neurosci. 2006 Jul 12;26(28):7502-12 [16837598] J Neurochem. 2006 Aug;98(4):1019-31 [16895577] J Biol Chem. 2006 Oct 13;281(41):30479-84 [16912034] Neurobiol Dis. 2006 Nov;24(2):213-25 [16950627] J Neurosci. 2007 Jan 24;27(4):868-80 [17251428] J Pharmacol Exp Ther. 2007 Jun;321(3):892-901 [17371805] Biol Psychiatry. 2007 Oct 1;62(7):711-21 [17568569] Biol Psychiatry. 2007 Dec 1;62(11):1310-6 [17574216] J Neurosci. 2007 Nov 28;27(48):13173-80 [18045911] Biochem J. 2008 Jan 15;409(2):581-9 [17868033] J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63 [17473852] J Neurosci. 2008 Jan 2;28(1):163-76 [18171934] EMBO J. 2008 Mar 19;27(6):827-39 [18288205] Ann Neurol. 2000 Jun;47(6):782-91 [10852544] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1471-4159.2009.06385.x ER - TY - JOUR T1 - Brief Report: IQ Split Predicts Social Symptoms and Communication Abilities in High-Functioning Children with Autism Spectrum Disorders AN - 57347915; 201002457 AB - We investigated the relationship of discrepancies between VIQ and NVIQ (IQ split) to autism symptoms and adaptive behavior in a sample of high-functioning (mean FSIQ=98.5) school-age children with autism spectrum disorders divided into three groups: discrepantly high VIQ (n=18); discrepantly high NVIQ (n=24); and equivalent VIQ and NVIQ (n=36). Discrepantly high VIQ and NVIQ were associated with autism social symptoms but not communication symptoms or repetitive behaviors. Higher VIQ and NVIQ were associated with better adaptive communication but not socialization or Daily Living Skills. IQ discrepancy may be an important phenotypic marker in autism. Although better verbal abilities are associated with better functional outcomes in autism, discrepantly high VIQ in high-functioning children may also be associated with social difficulties. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Black, David O AU - Wallace, Gregory L AU - Sokoloff, Jennifer L AU - Kenworthy, Lauren AD - Pediatric Developmental Neuroscience Branch, National Institute of Mental Health, 10 Center Drive, MSC 1255 Building 10, Room 4N208, Bethesda, MD, 20892-1255, USA blackdavid@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1613 EP - 1619 PB - Springer, Dordrecht The Netherlands VL - 39 IS - 11 SN - 0162-3257, 0162-3257 KW - High functioning KW - Symptoms KW - Discrepancies KW - Autistic children KW - Autism KW - Intelligence quotient KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57347915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Brief+Report%3A+IQ+Split+Predicts+Social+Symptoms+and+Communication+Abilities+in+High-Functioning+Children+with+Autism+Spectrum+Disorders&rft.au=Black%2C+David+O%3BWallace%2C+Gregory+L%3BSokoloff%2C+Jennifer+L%3BKenworthy%2C+Lauren&rft.aulast=Black&rft.aufirst=David&rft.date=2009-11-01&rft.volume=39&rft.issue=11&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-009-0795-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic children; Symptoms; High functioning; Intelligence quotient; Autism; Discrepancies DO - http://dx.doi.org/10.1007/s10803-009-0795-3 ER - TY - JOUR T1 - Intervention: Testing the effects of educational strategies on comprehension of a genomic concept using virtual reality technology AN - 57311563; 201000624 AB - Objective Applying genetic susceptibility information to improve health will likely require educating patients about abstract concepts, for which there is little existing research. This experimental study examined the effect of learning mode on comprehension of a genomic concept. Methods 156 individuals aged 18-40 without specialized knowledge were randomly assigned to either a virtual reality active learning or didactic learning condition. The outcome was comprehension (recall, transfer, mental models). Results Change in recall was greater for didactic learning than for active learning (p < 0.001). Mean transfer and change in mental models were also higher for didactic learning (p < 0.0001 and p < 0.05, respectively). Believability was higher for didactic learning (p < 0.05), while ratings for motivation (p < 0.05), interest (p < 0.0001), and enjoyment (p < 0.0001) were higher for active learning, but these variables did not mediate the association between learning mode and comprehension. Conclusion These results show that learning mode affects comprehension, but additional research is needed regarding how and in what contexts different approaches are best for educating patients about abstract concepts. Practice implications Didactic, interpersonal health education approaches may be more effective than interactive games in educating patients about abstract, unfamiliar concepts. These findings indicate the importance of traditional health education approaches in emerging areas like genomics. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Kaphingst, Kimberly A AU - Persky, Susan AU - McCall, Cade AU - Lachance, Christina AU - Loewenstein, Johanna AU - Beall, Andrew C AU - Blascovich, Jim AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, USA Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 224 EP - 230 PB - Elsevier Ltd, The Netherlands VL - 77 IS - 2 SN - 0738-3991, 0738-3991 KW - Patient education Learning approaches Genetics Genetic communication KW - Genetics KW - Learning KW - Virtual reality KW - Health education KW - Communication KW - Comprehension KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57311563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Intervention%3A+Testing+the+effects+of+educational+strategies+on+comprehension+of+a+genomic+concept+using+virtual+reality+technology&rft.au=Kaphingst%2C+Kimberly+A%3BPersky%2C+Susan%3BMcCall%2C+Cade%3BLachance%2C+Christina%3BLoewenstein%2C+Johanna%3BBeall%2C+Andrew+C%3BBlascovich%2C+Jim&rft.aulast=Kaphingst&rft.aufirst=Kimberly&rft.date=2009-11-01&rft.volume=77&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2009.03.029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-01-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Learning; Comprehension; Virtual reality; Communication; Health education; Genetics DO - http://dx.doi.org/10.1016/j.pec.2009.03.029 ER - TY - CPAPER T1 - The Future of Tumor Modulation and Tumor Cell Specific Adaptive Therapy T2 - 51st Annual Meeting of the American Society for Radiation Oncology AN - 42065940; 5515652 JF - 51st Annual Meeting of the American Society for Radiation Oncology AU - Gius, David AU - Dewhirst, Mark AU - Hallahan, Dennis Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 KW - Tumors KW - Tumor cells KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+American+Society+for+Radiation+Oncology&rft.atitle=The+Future+of+Tumor+Modulation+and+Tumor+Cell+Specific+Adaptive+Therapy&rft.au=Gius%2C+David%3BDewhirst%2C+Mark%3BHallahan%2C+Dennis&rft.aulast=Gius&rft.aufirst=David&rft.date=2009-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+American+Society+for+Radiation+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.astro.org/Meetings/AnnualMeetings/FinalProgram/documents/Fi nalProgram_2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A common standard for conflict of interest disclosure in addiction journals AN - 37288388; 3943555 AB - This paper presents a common standard for conflict of interest disclosure. The common standard was drafted by the authors, following consultation with a multi-disciplinary group of journal editors, publishers, bioethicists and other academics. It is presented here for the benefit of authors, editorial managers, journal editors and peer reviewers to stimulate discussion and to provide guidance to authors in reporting real, apparent and potential conflicts of interest. It is particularly relevant to addiction specialty journals because of the potential conflicts of interest associated with funding from the alcohol, tobacco, pharmaceutical and gambling industries. Following an appropriate period of vetting the common standard within the scientific community. It is recommended that journal editors adopt journal policies and reporting procedures that are consistent across journals. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Goozner, Merrill AU - Caplan, Arthur AU - Moreno, Jonathan AU - Kramer, Barnett S AU - Babor, Thomas F AU - Husser, Wendy C AD - Center for Science in the Public Interest Washington DC ; University of Pennsylvania ; National Cancer Institute ; University of Connecticut Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1779 EP - 1784 VL - 104 IS - 11 SN - 0965-2140, 0965-2140 KW - Sociology KW - Periodicals KW - Interest KW - Publishing KW - Social sciences KW - Corporate culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37288388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=A+common+standard+for+conflict+of+interest+disclosure+in+addiction+journals&rft.au=Goozner%2C+Merrill%3BCaplan%2C+Arthur%3BMoreno%2C+Jonathan%3BKramer%2C+Barnett+S%3BBabor%2C+Thomas+F%3BHusser%2C+Wendy+C&rft.aulast=Goozner&rft.aufirst=Merrill&rft.date=2009-11-01&rft.volume=104&rft.issue=11&rft.spage=1779&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2009.02594.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6632; 9397 7862 2572; 11920; 10496; 2885 3198 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02594.x ER - TY - JOUR T1 - How numeracy influences risk comprehension and medical decision making AN - 37287190; 3943522 AB - We review the growing literature on health numeracy, the ability to understand and use numerical information, and its relation to cognition, health behaviors, and medical outcomes. Despite the surfeit of health information from commercial and noncommercial sources, national and international surveys show that many people lack basic numerical skills that are essential to maintain their health and make informed medical decisions. Low numeracy distorts perceptions of risks and benefits of screening, reduces medication compliance, impedes access to treatments, impairs risk communication (limiting prevention efforts among the most vulnerable), and, based on the scant research conducted on outcomes, appears to adversely affect medical outcomes. Low numeracy is also associated with greater susceptibility to extraneous factors (i.e., factors that do not change the objective numerical information). That is, low numeracy increases susceptibility to effects of mood or how information is presented (e.g., as frequencies vs. percentages) and to biases in judgment and decision making (e.g., framing and ratio bias effects). Much of this research is not grounded in empirically supported theories of numeracy or mathematical cognition, which are crucial for designing evidence-based policies and interventions that are effective in reducing risk and improving medical decision making. To address this gap, we outline four theoretical approaches (psychophysical, computational, standard dual-process, and fuzzy trace theory), review their implications for numeracy, and point to avenues for future research. Reprinted by permission of the American Psychological Association JF - Psychological bulletin AU - Reyna, Valerie F AU - Nelson, Wendy L AU - Han, Paul K AU - Dieckmann, Nathan F AD - Cornell University ; National Cancer Institute, Bethesda Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 943 EP - 973 VL - 135 IS - 6 SN - 0033-2909, 0033-2909 KW - Sociology KW - Decision making KW - Risk KW - Doctors KW - Numeracy KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37287190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+bulletin&rft.atitle=How+numeracy+influences+risk+comprehension+and+medical+decision+making&rft.au=Reyna%2C+Valerie+F%3BNelson%2C+Wendy+L%3BHan%2C+Paul+K%3BDieckmann%2C+Nathan+F&rft.aulast=Reyna&rft.aufirst=Valerie&rft.date=2009-11-01&rft.volume=135&rft.issue=6&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Psychological+bulletin&rft.issn=00332909&rft_id=info:doi/10.1037%2Fa0017327 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11035; 2449 10404; 3322 6071 1542 11325; 8791; 3675 10299 13682 7883 8864 DO - http://dx.doi.org/10.1037/a0017327 ER - TY - JOUR T1 - Mutualistic Biofilm Communities Develop with Porphyromonas gingivalis and Initial, Early, and Late Colonizers of Enamel AN - 21323453; 11917099 AB - Porphyromonas gingivalis is present in dental plaque as early as 4 h after tooth cleaning, but it is also associated with periodontal disease, a late-developing event in the microbial successions that characterize daily plaque development. We report here that P. gingivalis ATCC 33277 is remarkable in its ability to interact with a variety of initial, early, middle, and late colonizers growing solely on saliva. Integration of P. gingivalis into multispecies communities was investigated by using two in vitro biofilm models. In flow cells, bacterial growth was quantified using fluorescently conjugated antibodies against each species, and static biofilm growth on saliva-submerged polystyrene pegs was analyzed by quantitative real-time PCR using species-specific primers. P. gingivalis could not grow as a single species or together with initial colonizer Streptococcus oralis but showed mutualistic growth when paired with two other initial colonizers, Streptococcus gordonii and Actinomyces oris, as well as with Veillonella sp. (early colonizer), Fusobacterium nucleatum (middle colonizer), and Aggregatibacter actinomycetemcomitans (late colonizer). In three-species flow cells, P. gingivalis grew with Veillonella sp. and A. actinomycetemcomitans but not with S. oralis and A. actinomycetemcomitans. Also, it grew with Veillonella sp. and F. nucleatum but not with S. oralis and F. nucleatum, indicating that P. gingivalis and S. oralis are not compatible. However, P. gingivalis grew in combination with S. gordonii and S. oralis, demonstrating its ability to overcome the incompatibility when cultured with a second initially colonizing species. Collectively, these data help explain the observed presence of P. gingivalis at all stages of dental plaque development. JF - Journal of Bacteriology AU - Periasamy, Saravanan AU - Kolenbrander, Paul E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, pkolenbrander@dir.nidcr.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 6804 EP - 6811 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 22 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Teeth KW - Data processing KW - Porphyromonas gingivalis KW - Succession KW - Dental plaque KW - Fusobacterium nucleatum KW - Periodontal diseases KW - Integration KW - Antibodies KW - Streptococcus gordonii KW - Veillonella KW - polystyrene KW - Polymerase chain reaction KW - Plaques KW - Primers KW - Saliva KW - Biofilms KW - Actinomyces KW - Dental enamel KW - Streptococcus oralis KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21323453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mutualistic+Biofilm+Communities+Develop+with+Porphyromonas+gingivalis+and+Initial%2C+Early%2C+and+Late+Colonizers+of+Enamel&rft.au=Periasamy%2C+Saravanan%3BKolenbrander%2C+Paul+E&rft.aulast=Periasamy&rft.aufirst=Saravanan&rft.date=2009-11-01&rft.volume=191&rft.issue=22&rft.spage=6804&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01006-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 23 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Teeth; Data processing; Dental plaque; Succession; Periodontal diseases; Integration; Antibodies; polystyrene; Polymerase chain reaction; Primers; Plaques; Biofilms; Saliva; Dental enamel; Streptococcus gordonii; Porphyromonas gingivalis; Veillonella; Fusobacterium nucleatum; Actinomyces; Streptococcus oralis DO - http://dx.doi.org/10.1128/JB.01006-09 ER - TY - JOUR T1 - Cripto-1 Is Required for Hypoxia to Induce Cardiac Differentiation of Mouse Embryonic Stem Cells AN - 21321182; 11675598 AB - Cripto-1 is a membrane-bound protein that is highly expressed in embryonic stem cells and in human tumors. In the present study, we investigated the effect of low levels of oxygen, which occurs naturally in rapidly growing tissues, on Cripto-1 expression in mouse embryonic stem (mES) cells and in human embryonal carcinoma cells. During hypoxia, Cripto-1 expression levels were significantly elevated in mES cells and in Nera-2 or NCCIT human embryonal carcinoma cells, as compared with cells growing with normal oxygen levels. The transcription factor hypoxia-inducible factor-1a directly regulated Cripto-1 expression by binding to hypoxia-responsive elements within the promoter of mouse and human Cripto-1 genes in mES and NCCIT cells, respectively. Furthermore, hypoxia modulated differentiation of mES cells by enhancing formation of beating cardiomyocytes as compared with mES cells that were differentiated under normoxia. However, hypoxia failed to induce differentiation of mES cells into cardiomyocytes in the absence of Cripto-1 expression, demonstrating that Cripto-1 is required for hypoxia to fully differentiate mES cells into cardiomyocytes. Finally, cardiac tissue samples derived from patients who had suffered ischemic heart disease showed a dramatic increase in Cripto-1 expression as compared with nonischemic heart tissue samples, suggesting that hypoxia may also regulate Cripto-1 in vivo. JF - American Journal of Pathology AU - Bianco, C AU - Cotten, C AU - Lonardo, E AU - Strizzi, L AU - Baraty, C AU - Mancino, M AU - Gonzales, M AU - Watanabe, K AU - Nagaoka, T AU - Berry, C AU - Arai, A E AU - Minchiotti, G AU - Salomon, D S AD - Mammary Biology and Tumorigenesis Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 2146 EP - 2158 VL - 175 IS - 5 SN - 0002-9440, 0002-9440 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - cardiomyocytes KW - Ischemia KW - Tumors KW - Hypoxia-inducible factor 1a KW - Differentiation KW - Oxygen KW - Promoters KW - Stem cells KW - Embryo cells KW - Transcription factors KW - Heart diseases KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21321182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Cripto-1+Is+Required+for+Hypoxia+to+Induce+Cardiac+Differentiation+of+Mouse+Embryonic+Stem+Cells&rft.au=Bianco%2C+C%3BCotten%2C+C%3BLonardo%2C+E%3BStrizzi%2C+L%3BBaraty%2C+C%3BMancino%2C+M%3BGonzales%2C+M%3BWatanabe%2C+K%3BNagaoka%2C+T%3BBerry%2C+C%3BArai%2C+A+E%3BMinchiotti%2C+G%3BSalomon%2C+D+S&rft.aulast=Bianco&rft.aufirst=C&rft.date=2009-11-01&rft.volume=175&rft.issue=5&rft.spage=2146&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2009.090218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Hypoxia-inducible factor 1a; Promoters; Oxygen; Differentiation; Stem cells; Embryo cells; Transcription factors; Tumors; Ischemia; cardiomyocytes; Heart diseases DO - http://dx.doi.org/10.2353/ajpath.2009.090218 ER - TY - JOUR T1 - On Confounded Fishy Results Regarding Arsenic and Diabetes AN - 21316433; 11848873 AB - In 2008, Navas-Acien et al super(1) published a report suggesting that exposure to inorganic arsenic was associated with type 2 diabetes mellitus in a population with relatively low exposure. Although the report was based on only 93 cases and cross-sectional data, it appeared in a prominent journal and received much press. The biomarkers of exposure, while relatively sophisticated, were hobbled due to high detection limits for several arsenic species and by the fact they reflected only recent exposure. The data were from the 2003-2004 National Health and Nutrition Examination Survey (NHANES), meaning they were generalizable to the United States, and also easily accessible by others. In this issue of Epidemiology, Steinmaus et al super(2) present their analysis of the same data, in which they report no association. The Editors invited Navas-Acien et al to provide a defense of their previous work, which the authors did by augmenting their analysis with newer NHANES data. super(3) Interpretation of these conflicting results may affect the direction of future research. It's worth examining the technical issues behind the debate. JF - Epidemiology AU - Longnecker, M P AD - National Institute of Environmental Health Sciences, Epidemiology Branch, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA, longnec1@niehs.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 821 EP - 823 VL - 20 IS - 6 SN - 1044-3983, 1044-3983 KW - Toxicology Abstracts KW - Diabetes mellitus KW - Arsenic KW - Data processing KW - Epidemiology KW - Nutrition KW - biomarkers KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21316433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology&rft.atitle=On+Confounded+Fishy+Results+Regarding+Arsenic+and+Diabetes&rft.au=Longnecker%2C+M+P&rft.aulast=Longnecker&rft.aufirst=M&rft.date=2009-11-01&rft.volume=20&rft.issue=6&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Epidemiology&rft.issn=10443983&rft_id=info:doi/10.1097%2FEDE.0b013e3181b26bce LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Arsenic; Data processing; Epidemiology; biomarkers; Nutrition DO - http://dx.doi.org/10.1097/EDE.0b013e3181b26bce ER - TY - JOUR T1 - Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection AN - 21289386; 11699970 AB - Analyzing specialized cells in heterogeneous tissues is crucial for understanding organ function in health and disease. Thus far, however, there has been no convenient method for studying gene expression in cells purified by fluorescence-activated cell sorting (FACS) using intracellular markers. Here we show that the quantitative nuclease protection assay (qNPA) enables transcriptional analysis of intracytoplasmically stained cells sorted by FACS. Applying the method to mouse pancreatic islet-cell subsets, we detected both expected and unknown lineage-specific gene expression patterns. Some beta cells from pregnant animals were found to express Mafb, previously observed only in immature beta cells during embryonic development. The four 'housekeeping' genes tested were expressed in purified islet-cell subpopulations with a notable variability, dependent on both cell lineage and developmental stage. Application of qNPA to intracellularly stained, FACS-sorted cells should be broadly applicable to the analysis of gene expression in subpopulations of any heterogeneous tissue, including tumors. JF - Nature Biotechnology AU - Pechhold, Susanne AU - Stouffer, Melissa AU - Walker, Gregory AU - Martel, Ralph AU - Seligmann, Bruce AU - Hang, Yan AU - Stein, Roland AU - Harlan, David M AU - Pechhold, Klaus AD - [1] Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. [2] These authors contributed equally to this work. Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1038 EP - 1042 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - 11 SN - 1087-0156, 1087-0156 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Gene expression KW - Cell lineage KW - Embryogenesis KW - Pancreas KW - Beta cells KW - Transcription KW - Nuclease KW - Developmental stages KW - Tumors KW - Pregnancy KW - W 30910:Imaging KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21289386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Transcriptional+analysis+of+intracytoplasmically+stained%2C+FACS-purified+cells+by+high-throughput%2C+quantitative+nuclease+protection&rft.au=Pechhold%2C+Susanne%3BStouffer%2C+Melissa%3BWalker%2C+Gregory%3BMartel%2C+Ralph%3BSeligmann%2C+Bruce%3BHang%2C+Yan%3BStein%2C+Roland%3BHarlan%2C+David+M%3BPechhold%2C+Klaus&rft.aulast=Pechhold&rft.aufirst=Susanne&rft.date=2009-11-01&rft.volume=27&rft.issue=11&rft.spage=1038&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt.1579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cell lineage; Gene expression; Flow cytometry; Embryogenesis; Pancreas; Developmental stages; Nuclease; Transcription; Beta cells; Tumors; Pregnancy DO - http://dx.doi.org/10.1038/nbt.1579 ER - TY - JOUR T1 - Rimonabant-induced catatonia in schizophrenia: A case report AN - 21281115; 11786835 AB - Patients with psychiatric illness have higher rates of mortality and medical co-morbidity related to increased rates of diabetes mellitus and cardiovascular disease. Rimonabant, a cannabinoid receptor (CB1) antagonist, is an anti-obesity agent and decreases risk for metabolic syndrome. Though there are reports of rimonabant associated with adverse psychiatric events like depression, rimonabant-induced catatonia is not reported. In this first time report, we describe a patient with schizophrenia developing catatonia possibly due to rimonabant. JF - Obesity Research & Clinical Practice AU - Reddy, Nalini N AU - Rao, Naren P AU - Venkatasubramanian, Ganesan AU - Arasappa, Rashmi AU - Behere, Rishikesh V AU - Divakaran, Anjith AU - Sivakumar, Palanimuthu T AU - Gangadhar, Bangalore N AD - The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India, venkat.nimhans@yahoo.com Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 237 EP - 239 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 3 IS - 4 SN - 1871-403X, 1871-403X KW - Toxicology Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Schizophrenia KW - Catatonia KW - Rimonabant KW - Metabolic syndrome KW - Obesity KW - Mortality KW - metabolic disorders KW - Depression KW - Metabolic disorders KW - obesity KW - depression KW - Morbidity KW - Diabetes mellitus KW - diabetes mellitus KW - Mental disorders KW - Case reports KW - Cardiovascular diseases KW - Cannabinoid CB1 receptors KW - mental disorders KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21281115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research+%26+Clinical+Practice&rft.atitle=Rimonabant-induced+catatonia+in+schizophrenia%3A+A+case+report&rft.au=Reddy%2C+Nalini+N%3BRao%2C+Naren+P%3BVenkatasubramanian%2C+Ganesan%3BArasappa%2C+Rashmi%3BBehere%2C+Rishikesh+V%3BDivakaran%2C+Anjith%3BSivakumar%2C+Palanimuthu+T%3BGangadhar%2C+Bangalore+N&rft.aulast=Reddy&rft.aufirst=Nalini&rft.date=2009-11-01&rft.volume=3&rft.issue=4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Obesity+Research+%26+Clinical+Practice&rft.issn=1871403X&rft_id=info:doi/10.1016%2Fj.orcp.2009.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Schizophrenia; Obesity; Mortality; Mental disorders; Depression; Case reports; Metabolic disorders; Cardiovascular diseases; Cannabinoid CB1 receptors; Catatonia; diabetes mellitus; metabolic disorders; obesity; depression; mental disorders; Morbidity DO - http://dx.doi.org/10.1016/j.orcp.2009.04.002 ER - TY - JOUR T1 - Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries AN - 21276280; 11699972 AB - The cytochrome P450 (CYP) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug development. We determined potency values for 17,143 compounds against five recombinant CYP isozymes (1A2, 2C9, 2C19, 2D6 and 3A4) using an in vitro bioluminescent assay. The compounds included libraries of US Food and Drug Administration (FDA)-approved drugs and screening libraries. We observed cross-library isozyme inhibition (30-78%) with important differences between libraries. Whereas only 7% of the typical screening library was inactive against all five isozymes, 33% of FDA-approved drugs were inactive, reflecting the optimized pharmacological properties of the latter. Our results suggest that low CYP 2C isozyme activity is a common property of drugs, whereas other isozymes, such as CYP 2D6, show little discrimination between drugs and unoptimized compounds found in screening libraries. We also identified chemical substructures that differentiated between the five isozymes. The pharmacological compendium described here should further the understanding of CYP isozymes. JF - Nature Biotechnology AU - Veith, Henrike AU - Southall, Noel AU - Huang, Ruili AU - James, Tim AU - Fayne, Darren AU - Artemenko, Natalia AU - Shen, Min AU - Inglese, James AU - Austin, Christopher P AU - Lloyd, David G AU - Auld, Douglas S AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1050 EP - 1055 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - 11 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts KW - Drug discrimination KW - Drug metabolism KW - Isoenzymes KW - Drug development KW - Cytochrome P450 KW - Drug screening KW - CYP gene KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21276280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Comprehensive+characterization+of+cytochrome+P450+isozyme+selectivity+across+chemical+libraries&rft.au=Veith%2C+Henrike%3BSouthall%2C+Noel%3BHuang%2C+Ruili%3BJames%2C+Tim%3BFayne%2C+Darren%3BArtemenko%2C+Natalia%3BShen%2C+Min%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BLloyd%2C+David+G%3BAuld%2C+Douglas+S&rft.aulast=Veith&rft.aufirst=Henrike&rft.date=2009-11-01&rft.volume=27&rft.issue=11&rft.spage=1050&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt.1581 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug metabolism; Drug discrimination; Isoenzymes; Drug development; Cytochrome P450; Drug screening; CYP gene DO - http://dx.doi.org/10.1038/nbt.1581 ER - TY - JOUR T1 - A randomized, phase II, dose-finding study of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in patients with pretreated metastatic breast cancer AN - 21246490; 10990347 AB - Purpose: To evaluate the efficacy and safety of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in metastatic breast cancer (MBC). Experimental design: Patients with measurable, progressive, or recurrent MBC whose primary tumor expressed .1 ErbB receptor were randomized to the following CI-1033 regimens: 50mg (arm A) or 150mg (arm B) daily without rest period, or 450mg/day14days every 21days (arm C). The primary endpoint was 1-year progression-free survival (PFS). Results: Overall, 194 patients were treated. One-year PFS estimates were 3.8, 2.0, and 4.6%; median PFS was 61, 56, and 58days; and investigator-assessed overall response rates were 1.5, 1.5, and 7.3%, in arms A, B, and C, respectively. Response duration was 110-419days. In arm C, response (18.8 vs. 2.6%) and 1-year overall survival rates (86.7 vs. 47.5%) were greater in patients with HER2-positive versus HER2-negative tumors. The incidence of grade 3/4 adverse events (AEs) was dose-dependent, affecting 10.3, 48.6, and 80.4% of patients in arms A, B and C, respectively. The most common grade 3/4, treatment-related AEs were diarrhea, asthenia, and stomatitis. Arm C enrollment was prematurely discontinued due to a high frequency of grade 3/4 AEs. Conclusion: Single-agent CI-1033 did not show clinically meaningful activity in heavily pretreated patients with MBC expressing .1 ErbB receptor. Antitumor activity was observed in arm C patients with HER2-positive tumors. However, only the 50mg dose was well tolerated, and the highest dose reached unacceptable levels of toxicity. JF - Cancer Chemotherapy and Pharmacology AU - Rixe, Olivier AU - Franco, Sandra X AU - Yardley, Denise A AU - Johnston, Stephen R AU - Martin, Miguel AU - Arun, Banu K AU - Letrent, Stephen P AU - Rugo, Hope S AD - Hopital de la Pitie Salpetriere, APHP, Paris, France, rixeo@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1139 EP - 1148 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 64 IS - 6 SN - 0344-5704, 0344-5704 KW - Toxicology Abstracts KW - Metastases KW - Diarrhea KW - Stomatitis KW - Asthenia KW - ErbB protein KW - Survival KW - Breast cancer KW - Tumors KW - Toxicity KW - Antitumor activity KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21246490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=A+randomized%2C+phase+II%2C+dose-finding+study+of+the+pan-ErbB+receptor+tyrosine-kinase+inhibitor+CI-1033+in+patients+with+pretreated+metastatic+breast+cancer&rft.au=Rixe%2C+Olivier%3BFranco%2C+Sandra+X%3BYardley%2C+Denise+A%3BJohnston%2C+Stephen+R%3BMartin%2C+Miguel%3BArun%2C+Banu+K%3BLetrent%2C+Stephen+P%3BRugo%2C+Hope+S&rft.aulast=Rixe&rft.aufirst=Olivier&rft.date=2009-11-01&rft.volume=64&rft.issue=6&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=03445704&rft_id=info:doi/10.1007%2Fs00280-009-0975-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metastases; Diarrhea; Stomatitis; Asthenia; ErbB protein; Breast cancer; Survival; Toxicity; Tumors; Antitumor activity DO - http://dx.doi.org/10.1007/s00280-009-0975-z ER - TY - JOUR T1 - Adding Insult to Injury: Reluctance to Engage in Clinical Research with At-Risk Groups Further Disenfranchises These Populations AN - 21233660; 11824446 JF - American Journal of Bioethics AU - Lynch, Holly Fernandez AU - Dawson, Liza AD - Bioethicist, Human Subjects Protection Branch, HJF-DAIDS, National Institute of Allergy and Infectious Diseases, Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 62 EP - 64 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 9 IS - 11 SN - 1526-5161, 1526-5161 KW - Environment Abstracts KW - Injuries KW - clinical trials KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21233660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Bioethics&rft.atitle=Adding+Insult+to+Injury%3A+Reluctance+to+Engage+in+Clinical+Research+with+At-Risk+Groups+Further+Disenfranchises+These+Populations&rft.au=Lynch%2C+Holly+Fernandez%3BDawson%2C+Liza&rft.aulast=Lynch&rft.aufirst=Holly&rft.date=2009-11-01&rft.volume=9&rft.issue=11&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265160903197655 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - clinical trials; Injuries DO - http://dx.doi.org/10.1080/15265160903197655 ER - TY - JOUR T1 - Partial Nephrectomy After Previous Radio Frequency Ablation: The National Cancer Institute Experience AN - 21216134; 11179903 AB - Purpose - Development of new renal tumors or recurrence after radio frequency ablation not amendable for repeat ablation presents a difficult therapeutic dilemma. We report on the outcomes of partial nephrectomy on kidneys previously treated with radio frequency ablation. Materials and Methods - We performed a chart review of 13 patients who underwent 16 attempted partial nephrectomies following radio frequency ablation. Hospital records and operative reports were reviewed for demographic data, perioperative data and outcomes. The outcomes of the present series were compared to historical controls of published studies in similar patient populations. Results - No cases were converted to radical nephrectomy. Median time from radio frequency ablation to surgery was 2.75 years (range 1 to 7.1). A median of 7 tumors (range 2 to 40) were removed with a median estimated blood loss of 1,500 ml (range 500 to 3,500) and a median operative time of 7.8 hours (range 5 to 10.7). Operative notes commented on the presence of severe fibrosis in the operative field in 12 of 16 cases (75%). There was a modest but statistically significant decrease in renal function. Partial nephrectomy after radio frequency ablation had a higher reoperation rate compared to other series of primary or repeat partial nephrectomies but had the lowest rate of vascular or visceral injuries. Conclusions - Partial nephrectomy on kidneys previously treated with radio frequency ablation is a technically challenging but feasible procedure. Residual or metachronous disease after radio frequency ablation may be salvaged with partial nephrectomy with a modest decrease in renal function. A trend toward a higher chance of reoperation and urine leak after partial nephrectomy after radio frequency ablation may be useful information for the planning and discussion of treatment decisions. JF - Journal of Urology AU - Kowalczyk, Keith J AU - Hooper, HBrooks AU - Linehan, WMarston AU - Pinto, Peter A AU - Wood, Bradford J AU - Bratslavsky, Gennady AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, bratslag@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 2158 EP - 2163 PB - Elsevier Inc. VL - 182 IS - 5 SN - 0022-5347, 0022-5347 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - Injuries KW - Fibrosis KW - Statistical analysis KW - Tumors KW - Demography KW - Blood KW - Renal function KW - Urine KW - Nephrectomy KW - Surgery KW - Vascular system KW - Radicals KW - Hospitals KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21216134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urology&rft.atitle=Partial+Nephrectomy+After+Previous+Radio+Frequency+Ablation%3A+The+National+Cancer+Institute+Experience&rft.au=Kowalczyk%2C+Keith+J%3BHooper%2C+HBrooks%3BLinehan%2C+WMarston%3BPinto%2C+Peter+A%3BWood%2C+Bradford+J%3BBratslavsky%2C+Gennady&rft.aulast=Kowalczyk&rft.aufirst=Keith&rft.date=2009-11-01&rft.volume=182&rft.issue=5&rft.spage=2158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urology&rft.issn=00225347&rft_id=info:doi/10.1016%2Fj.juro.2009.07.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Fibrosis; Statistical analysis; Tumors; Demography; Blood; Renal function; Nephrectomy; Urine; Surgery; Hospitals; Radicals; Vascular system DO - http://dx.doi.org/10.1016/j.juro.2009.07.064 ER - TY - JOUR T1 - LOW-DOSE EXTRAPOLATION OF RADIATION HEALTH RISKS: SOME IMPLICATIONS OF UNCERTAINTY FOR RADIATION PROTECTION AT LOW DOSES AN - 21205684; 11170608 AB - Ionizing radiation is a known and well-quantified human cancer risk factor, based on a remarkably consistent body of information from epidemiological studies of exposed populations. Typical examples of risk estimation include use of Japanese atomic bomb survivor data to estimate future risk from radiation-related cancer among American patients receiving multiple computed tomography scans, persons affected by radioactive fallout, or persons whose livelihoods involve some radiation exposure, such as x-ray technicians, interventional radiologists, or shipyard workers. Our estimates of radiation-related risk are uncertain, reflecting statistical variation and our imperfect understanding of crucial assumptions that must be made if we are to apply existing epidemiological data to particular situations. Fortunately, that uncertainty is also highly quantifiable, and can be presented concisely and transparently. Radiation protection is ultimately a political process that involves consent by stakeholders, a diverse group that includes people who might be expected to be risk-averse and concerned with plausible upper limits on risk (how bad could it be?), cost-averse and concerned with lower Omits on risk (can you prove there is a nontrivial risk at current dose levels?), or combining both points of view. How radiation-related risk is viewed by individuals and population subgroups also depends very much on perception of related benefit, which might be (for example) medical, economic, altruistic, or nonexistent The following presentation follows the lead of National Council on Radiation Protection and Measurements (NCRP) Commentary 14, NCRP Report 126, and later documents in treating radiation protection from the viewpoint of quantitative uncertainly analysis. JF - Health Physics AU - Land, CE AD - National Cancer Institute/National Institutes of Health, Radiation Epidemiology Branch EPS 7046, 6120 Executive Boulevard, MS7238, Bethesda, MD 20892-7238, USA, landc@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 407 EP - 415 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 97 IS - 5 SN - 0017-9078, 0017-9078 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts; Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Statistics KW - Politics KW - Atomic bombs KW - Radiation hazards KW - Lead KW - Risks KW - Fallout KW - Risk factors KW - Economics KW - stakeholders KW - Occupational exposure KW - Data processing KW - Population studies KW - risk aversion KW - Cancer KW - computed tomography KW - Radioactive fallout KW - Perception KW - Ionizing radiation KW - councils KW - Computed tomography KW - Population structure KW - Radiation protection KW - technicians KW - Japan KW - X 24390:Radioactive Materials KW - Q5 08503:Characteristics, behavior and fate KW - O 4080:Pollution - Control and Prevention KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21205684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=LOW-DOSE+EXTRAPOLATION+OF+RADIATION+HEALTH+RISKS%3A+SOME+IMPLICATIONS+OF+UNCERTAINTY+FOR+RADIATION+PROTECTION+AT+LOW+DOSES&rft.au=Land%2C+CE&rft.aulast=Land&rft.aufirst=CE&rft.date=2009-11-01&rft.volume=97&rft.issue=5&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Ionizing radiation; Population structure; Radiation protection; Radiation hazards; Risks; Data processing; Statistics; Atomic bombs; Population studies; Cancer; Lead; Fallout; Perception; Risk factors; Economics; Computed tomography; Occupational exposure; Politics; risk aversion; computed tomography; Radioactive fallout; councils; stakeholders; technicians; Japan ER - TY - JOUR T1 - MT1-MMP and Type II Collagen Specify Skeletal Stem Cells and Their Bone and Cartilage Progeny AN - 21204392; 11289997 AB - Skeletal formation is dependent on timely recruitment of skeletal stem cells and their ensuing synthesis and remodeling of the major fibrillar collagens, type I collagen and type II collagen, in bone and cartilage tissues during development and postnatal growth. Loss of the major collagenolytic activity associated with the membrane-type 1 matrix metalloproteinase (MT1-MMP) results in disrupted skeletal development and growth in both cartilage and bone, where MT1-MMP is required for pericellular collagen dissolution. We show here that reconstitution of MT1-MMP activity in the type II collagen-expressing cells of the skeleton rescues not only diminished chondrocyte proliferation, but surprisingly, also results in amelioration of the severe skeletal dysplasia associated with MT1-MMP deficiency through enhanced bone formation. Consistent with this increased bone formation, type II collagen was identified in bone cells and skeletal stem/progenitor cells of wildtype mice. Moreover, bone marrow stromal cells isolated from mice expressing MT1-MMP under the control of the type II collagen promoter in an MT1-MMP-deficient background showed enhanced bone formation in vitro and in vivo compared with cells derived from nontransgenic MTl-MMP-deficient litter-mates. These observations show that type II collagen is not stringently confined to the chondrocyte but is expressed in skeletal stem/progenitor cells (able to regenerate bone, cartilage, myelosupportive stroma, marrow adipocytes) and in the chondrogenic and osteogenic lineage progeny where collagenolytic activity is a requisite for proper cell and tissue function. JF - Journal of Bone and Mineral Research AU - Szabova, L AU - Yamada, S S AU - Wimer, H AU - Chrysovergis, K AU - Ingvarsen, S AU - Behrendt, N AU - Engelholm, L H AU - Holmbeck, K AD - NIH, Building 30, Room 125, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA, kenn.holmbeck@nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1905 EP - 1916 VL - 24 IS - 11 SN - 0884-0431, 0884-0431 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - stromal cells KW - Cartilage KW - Bone growth KW - Bone marrow KW - Matrix metalloproteinase KW - Chondrocytes KW - Bone dysplasia KW - Promoters KW - Stem cells KW - Adipocytes KW - Bone loss KW - Dissolution KW - Progeny KW - Collagen (type II) KW - Cell proliferation KW - Collagen (type I) KW - Skeleton KW - Osteogenesis KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21204392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Research&rft.atitle=MT1-MMP+and+Type+II+Collagen+Specify+Skeletal+Stem+Cells+and+Their+Bone+and+Cartilage+Progeny&rft.au=Szabova%2C+L%3BYamada%2C+S+S%3BWimer%2C+H%3BChrysovergis%2C+K%3BIngvarsen%2C+S%3BBehrendt%2C+N%3BEngelholm%2C+L+H%3BHolmbeck%2C+K&rft.aulast=Szabova&rft.aufirst=L&rft.date=2009-11-01&rft.volume=24&rft.issue=11&rft.spage=1905&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/10.1359%2FJBMR.090510 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - stromal cells; Cartilage; Bone marrow; Bone growth; Chondrocytes; Matrix metalloproteinase; Bone dysplasia; Promoters; Stem cells; Adipocytes; Bone loss; Dissolution; Collagen (type II); Progeny; Cell proliferation; Collagen (type I); Osteogenesis; Skeleton DO - http://dx.doi.org/10.1359/JBMR.090510 ER - TY - JOUR T1 - Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists AN - 21166089; 11239376 AB - Ionizing radiation-associated breast cancer risk appears to be modified by timing of reproductive events such as age at radiation exposure, parity, age at first live birth, and age at menopause. However, potential breast cancer risk modification of low to moderate radiation dose by polymorphic estrogen metabolism-related gene variants has not been routinely investigated. We assessed breast cancer risk of 12 candidate variants in 12 genes involved in steroid metabolism, catabolism, binding, or receptor functions in a study of 859 cases and 1,083 controls within the US radiologic technologists (USRT) cohort. Using cumulative breast dose estimates from a detailed assessment of occupational and personal diagnostic ionizing radiation exposure, we investigated the joint effects of genotype on the risk of breast cancer. In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the CYP3A4 M445T minor allele (rs4986910, OR=0.3; 95% CI 0.1-0.9). We found a borderline increased breast cancer risk with having both minor alleles of CYP1B1 V432L (rs1056836, CC vs. GG, OR=1.2; 95% CI 0.9-1.6). Assuming a recessive model, the minor allele of CYP1B1 V432L significantly increased the dose-response relationship between personal diagnostic X-ray exposure and breast cancer risk, adjusted for cumulative occupational radiation dose (p sub(interaction)=0.03) and had a similar joint effect for cumulative occupational radiation dose adjusted for personal diagnostic X-ray exposure (p sub(interaction)=0.06). We found suggestive evidence that common variants in selected estrogen metabolizing genes may modify the association between ionizing radiation exposure and breast cancer risk. JF - Breast Cancer Research and Treatment AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Chang, Shih-chen AU - Rajaraman, Preetha AU - Doody, Michele M AU - Bowen, Laura AU - Simon, Steven L AU - Weinstock, Robert M AU - Linet, Martha S AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Alexander, Bruce H AU - Preston, Dale L AU - Struewing, Jeffery P AD - Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA, sigurdsa@mail.nih.gov sigurdsa@mail.nih.gov sigurdsa@mail.nih.gov sigurdsa@mail.nih.gov sigurdsa@mail.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 177 EP - 184 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 118 IS - 1 SN - 0167-6806, 0167-6806 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Parity KW - Age KW - Estrogens KW - Gene polymorphism KW - Steroid hormones KW - Models KW - Multivariate analysis KW - Risk factors KW - Dose-response effects KW - Ionizing radiation KW - Breast cancer KW - Metabolism KW - Occupational exposure KW - Menopause KW - W 30960:Bioinformatics & Computer Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21166089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research+and+Treatment&rft.atitle=Polymorphisms+in+estrogen+biosynthesis+and+metabolism-related+genes%2C+ionizing+radiation+exposure%2C+and+risk+of+breast+cancer+among+US+radiologic+technologists&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BChang%2C+Shih-chen%3BRajaraman%2C+Preetha%3BDoody%2C+Michele+M%3BBowen%2C+Laura%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BLinet%2C+Martha+S%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAlexander%2C+Bruce+H%3BPreston%2C+Dale+L%3BStruewing%2C+Jeffery+P&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2009-11-01&rft.volume=118&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research+and+Treatment&rft.issn=01676806&rft_id=info:doi/10.1007%2Fs10549-009-0307-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Parity; Estrogens; Age; Gene polymorphism; Steroid hormones; Models; Multivariate analysis; Ionizing radiation; Dose-response effects; Risk factors; Breast cancer; Menopause; Occupational exposure; Metabolism DO - http://dx.doi.org/10.1007/s10549-009-0307-3 ER - TY - JOUR T1 - Visual Acuity Outcomes after Cataract Surgery in Patients with Age-Related Macular Degeneration: Age-Related Eye Disease Study Report No. 27 AN - 21138514; 11315094 AB - Objective - To evaluate visual acuity outcomes after cataract surgery in patients with varying degrees of age-related macular degeneration (AMD). Design - Cohort study. Participants - A total of 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), a prospective, multicenter, epidemiological study of the clinical course of cataract and AMD and a randomized controlled trial of antioxidants and minerals. Methods - Standardized lens and fundus photographs, performed at baseline and annual visits, were graded by a centralized reading center using standardized protocols for severity of AMD and lens opacities. History of cataract surgery was obtained every 6 months. Analyses were conducted using multivariate logistic regression. Main Outcome Measure - The change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA. Results - Visual acuity results were analyzed for 1939 eyes that had cataract surgery during AREDS. The mean time from cataract surgery to measurement of postoperative BCVA was 6.9 months. After adjustment for age at surgery, gender, type, and severity of cataract, the mean change in visual acuity at the next study visit after the cataract surgery was as follows: Eyes without AMD gained 8.4 letters of acuity (P<0.0001), eyes with mild AMD gained 6.1 letters of visual acuity (P<0.0001), eyes with moderate AMD gained 3.9 letters (P<0.0001), and eyes with advanced AMD gained 1.9 letters (P = 0.04). The statistically significant gain in visual acuity after cataract surgery was maintained an average of 1.4 years after cataract surgery. Conclusions - On average, participants with varying severity of AMD benefited from cataract surgery with an increase in visual acuity postoperatively. This average gain in visual acuity persisted for at least 18 months. Financial Disclosure(s) - The author(s) have no proprietary or commercial interest in any materials discussed in this article. JF - Ophthalmology AU - Forooghian, Farzin AU - Agron, Elvira AU - Clemons, Traci E AU - Ferris, Frederick L AU - Chew, Emily Y AD - Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute/National Institutes of Health, Bethesda, Maryland, echew@nei.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 2093 EP - 2100 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 116 IS - 11 SN - 0161-6420, 0161-6420 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Age KW - Antioxidants KW - Cataracts KW - Macular degeneration KW - Acuity KW - Eye lens KW - Statistical analysis KW - Clinical trials KW - Surgery KW - Eye diseases KW - Language KW - Minerals KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21138514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ophthalmology&rft.atitle=Visual+Acuity+Outcomes+after+Cataract+Surgery+in+Patients+with+Age-Related+Macular+Degeneration%3A+Age-Related+Eye+Disease+Study+Report+No.+27&rft.au=Forooghian%2C+Farzin%3BAgron%2C+Elvira%3BClemons%2C+Traci+E%3BFerris%2C+Frederick+L%3BChew%2C+Emily+Y&rft.aulast=Forooghian&rft.aufirst=Farzin&rft.date=2009-11-01&rft.volume=116&rft.issue=11&rft.spage=2093&rft.isbn=&rft.btitle=&rft.title=Ophthalmology&rft.issn=01616420&rft_id=info:doi/10.1016%2Fj.ophtha.2009.04.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Antioxidants; Macular degeneration; Cataracts; Surgery; Eye diseases; Statistical analysis; Eye lens; Acuity; Language; Minerals; Clinical trials DO - http://dx.doi.org/10.1016/j.ophtha.2009.04.033 ER - TY - JOUR T1 - Meat and Meat-related Compounds and Risk of Prostate Cancer in a Large Prospective Cohort Study in the United States AN - 21135922; 11223701 AB - The authors examined associations between meat consumption (type, cooking method, and related mutagens), heme iron, nitrite/nitrate, and prostate cancer in a cohort of 175,343 US men aged 50-71 years. During 9 years of follow-up (1995-2003), they ascertained 10,313 prostate cancer cases (1,102 advanced) and 419 fatal cases. Hazard ratios comparing the fifth intake quintile with the first revealed elevated risks associated with red and processed meat for total (red meat: hazard ratio (HR) = 1.12, 95% confidence interval (CI): 1.04, 1.21; processed meat: HR = 1.07, 95% CI: 1.00, 1.14) and advanced (red meat: HR = 1.31, 95% CI: 1.05, 1.65; processed meat: HR = 1.32, 95% CI: 1.08, 1.61) prostate cancer. Heme iron, barbecued/grilled meat, and benzo[a]pyrene were all positively associated with total (HR = 1.09 (95% CI: 1.02, 1.17), HR = 1.11 (95% CI: 1.03, 1.19), and HR = 1.09 (95% CI: 1.00, 1.18), respectively) and advanced (HR = 1.28 (95% CI: 1.03, 1.58), HR = 1.36 (95% CI: 1.10, 1.69), and HR = 1.28 (95% CI: 1.00, 1.65), respectively) disease. Nitrite (HR = 1.24, 95% CI: 1.02, 1.51) and nitrate (HR = 1.31, 95% CI: 1.07, 1.61) intakes were associated with advanced prostate cancer. There were no clear associations for fatal prostate cancer. Red and processed meat may be positively associated with prostate cancer via mechanisms involving heme iron, nitrite/nitrate, grilling/barbecuing, and benzo[a]pyrene. JF - American Journal of Epidemiology AU - Sinha, Rashmi AU - Park, Yikyung AU - Graubard, Barry I AU - Leitzmann, Michael F AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Cross, Amanda J Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 1165 EP - 1177 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 170 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Nitrate KW - Mutagens KW - Nitrates KW - Heme KW - Meat KW - USA KW - Prostate cancer KW - Nitrites KW - Cooking KW - cooking KW - Benzo(a)pyrene KW - prostate cancer KW - Nitrite KW - Iron KW - H 11000:Diseases/Injuries/Trauma KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21135922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Meat+and+Meat-related+Compounds+and+Risk+of+Prostate+Cancer+in+a+Large+Prospective+Cohort+Study+in+the+United+States&rft.au=Sinha%2C+Rashmi%3BPark%2C+Yikyung%3BGraubard%2C+Barry+I%3BLeitzmann%2C+Michael+F%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BCross%2C+Amanda+J&rft.aulast=Sinha&rft.aufirst=Rashmi&rft.date=2009-11-01&rft.volume=170&rft.issue=9&rft.spage=1165&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp280 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Meat; Mutagens; Nitrate; Prostate cancer; Heme; Cooking; Benzo(a)pyrene; Nitrite; Iron; Nitrates; Nitrites; cooking; prostate cancer; USA DO - http://dx.doi.org/10.1093/aje/kwp280 ER - TY - JOUR T1 - Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors AN - 21124216; 11182586 AB - There is strong interest to study the involvement of brain cannabinoid subtype-1 (CB sub(1)) receptors in neuropsychiatric disorders with single photon emission computed tomography (SPECT) and a suitable radioligand. Here we report the synthesis of a novel high-affinity radioiodinated CB sub(1) receptor ligand ([ super(125)I] 8, [ super(125)I]1-(2-iodophenyl)-4-cyano-5-(4-methoxyphenyl)-N-(piper idin-1-yl)-1H- pyrazole-3-carboxylate, [ super(125)I]SD7015). By autoradiography in vitro, [ super(125)I] 8 showed selective binding to CB sub(1) receptors on human brain postmortem cryosections and now merits labeling with iodine-123 for further evaluation as a SPECT radioligand in non-human primate. JF - Bioorganic and Medicinal Chemistry Letters AU - Donohue, Sean R AU - Varnaes, Katarina AU - Jia, Zhisheng AU - Gulyas, Balazs AU - Pike, Victor W AU - Halldin, Christer AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, Sean_Donohue@tracer.nm.jhu.edu Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 6209 EP - 6212 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 21 SN - 0960-894X, 0960-894X KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Mental disorders KW - Brain KW - Cannabinoid CB1 receptors KW - Autoradiography KW - Primates KW - Single photon emission computed tomography KW - W 30910:Imaging KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+and+in+vitro+autoradiographic+evaluation+of+a+novel+high-affinity+radioiodinated+ligand+for+imaging+brain+cannabinoid+subtype-1+receptors&rft.au=Donohue%2C+Sean+R%3BVarnaes%2C+Katarina%3BJia%2C+Zhisheng%3BGulyas%2C+Balazs%3BPike%2C+Victor+W%3BHalldin%2C+Christer&rft.aulast=Donohue&rft.aufirst=Sean&rft.date=2009-11-01&rft.volume=19&rft.issue=21&rft.spage=6209&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.08.092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mental disorders; Neuroimaging; Brain; Autoradiography; Cannabinoid CB1 receptors; Single photon emission computed tomography; Primates DO - http://dx.doi.org/10.1016/j.bmcl.2009.08.092 ER - TY - JOUR T1 - Quantitation of cannabinoid CB sub(1) receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand AN - 21122083; 11059870 AB - [ super(11)C]MePPEP is a high affinity, CB sub(1) receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [ super(11)C]MePPEP to quantify CB sub(1) receptors in human brain as distribution volume calculated with the "gold standard" method of compartmental modeling and compared results with the simple measure of brain uptake. A total of 17 healthy subjects participated in 26 positron emission tomography (PET) scans, with 8 having two PET scans to assess retest variability. After injection of [ super(11)C]MePPEP, brain uptake of radioactivity was high (e.g., 3.6 SUV in putamen at [not, vert, similar] 60 min) and washed out very slowly. A two-tissue compartment model yielded values of distribution volume (which is proportional to receptor density) that were both well identified (SE 5%) and stable between 60 and 210 min. The simple measure of brain uptake (average concentration of radioactivity between 40 and 80 min) had good retest variability ([not, vert, similar] 8%) and moderate intersubject variability (16%, coefficient of variation). In contrast, distribution volume had two-fold greater retest variability ([not, vert, similar] 15%) and, thus, less precision. In addition, distribution volume had three-fold greater intersubject variability ([not, vert, similar] 52%). The decreased precision of distribution volume compared to brain uptake was likely due to the slow washout of radioactivity from brain and to noise in measurements of the low concentrations of [ super(11)C]MePPEP in plasma. These results suggest that brain uptake can be used for within subject studies (e.g., to measure receptor occupancy by medications) but that distribution volume remains the gold standard for accurate measurements between groups. JF - NeuroImage AU - Terry, Garth E AU - Liow, Jeih-San AU - Zoghbi, Sami S AU - Hirvonen, Jussi AU - Farris, Amanda G AU - Lerner, Alicja AU - Tauscher, Johannes T AU - Schaus, John M AU - Phebus, Lee AU - Felder, Christian C AU - Morse, Cheryl L AU - Hong, Jinsoo S AU - Pike, Victor W AU - Halldin, Christer AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA, robert.innis@nih.gov Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 362 EP - 370 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 48 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Positron emission tomography KW - Brain imaging KW - Neuroimaging KW - Inverse agonists KW - Brain KW - Receptor density KW - Radioactivity KW - Cannabinoid CB1 receptors KW - Quantitation KW - Putamen KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21122083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Quantitation+of+cannabinoid+CB+sub%281%29+receptors+in+healthy+human+brain+using+positron+emission+tomography+and+an+inverse+agonist+radioligand&rft.au=Terry%2C+Garth+E%3BLiow%2C+Jeih-San%3BZoghbi%2C+Sami+S%3BHirvonen%2C+Jussi%3BFarris%2C+Amanda+G%3BLerner%2C+Alicja%3BTauscher%2C+Johannes+T%3BSchaus%2C+John+M%3BPhebus%2C+Lee%3BFelder%2C+Christian+C%3BMorse%2C+Cheryl+L%3BHong%2C+Jinsoo+S%3BPike%2C+Victor+W%3BHalldin%2C+Christer%3BInnis%2C+Robert+B&rft.aulast=Terry&rft.aufirst=Garth&rft.date=2009-11-01&rft.volume=48&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.06.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inverse agonists; Neuroimaging; Receptor density; Positron emission tomography; Brain; Radioactivity; Cannabinoid CB1 receptors; Quantitation; Putamen DO - http://dx.doi.org/10.1016/j.neuroimage.2009.06.059 ER - TY - JOUR T1 - AhR-mediated gene expression in the developing mouse telencephalon AN - 21111643; 11143304 AB - We hypothesize that TCDD-induced developmental neurotoxicity is modulated through an AhR-dependent interaction with key regulatory neuronal differentiation pathways during telencephalon development. To test this hypothesis we examined global gene expression in both dorsal and ventral telencephalon tissues in E13.5 AhR-/- and wildtype mice exposed to TCDD or vehicle. Consistent with previous biochemical, pathological and behavioral studies, our results suggest TCDD initiated changes in gene expression in the developing telencephalon are primarily AhR-dependent, as no statistically significant gene expression changes are evident after TCDD exposure in AhR-/- mice. Based on a gene regulatory network for neuronal specification in the developing telencephalon, the present analysis suggests differentiation of GABAergic neurons in the ventral telencephalon is compromised in TCDD exposed and AhR-/- mice. In addition, our analysis suggests Sox11 may be directly regulated by AhR based on gene expression and comparative genomics analyses. In conclusion, this analysis supports the hypothesis that AhR has a specific role in the normal development of the telencephalon and provides a mechanistic framework for neurodevelopmental toxicity of chemicals that perturb AhR signaling. JF - Reproductive Toxicology AU - Gohlke, J M AU - Stockton, P S AU - Sieber, S AU - Foley, J AU - Portier, C J AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA, portier@niehs.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 321 EP - 328 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 28 IS - 3 SN - 0890-6238, 0890-6238 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Gene expression KW - Differentiation KW - g-Aminobutyric acid KW - Neurons KW - Neurotoxicity KW - Genomic analysis KW - Statistical analysis KW - TCDD KW - Telencephalon KW - Signal transduction KW - N3 11003:Developmental neuroscience KW - G 07730:Development & Cell Cycle KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21111643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+and+Electronic+Engineering&rft.atitle=An+adaptive+routing+algorithm+for+power+line+communication&rft.au=Xu%2C+W%3BLi%2C+Z%3BMa%2C+Y-S%3BZhang%2C+D&rft.aulast=Xu&rft.aufirst=W&rft.date=2010-12-01&rft.volume=8&rft.issue=6&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Information+and+Electronic+Engineering&rft.issn=16722892&rft_id=info:doi/1672-2892%282010%2906-0738-05 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Gene expression; Differentiation; g-Aminobutyric acid; Neurons; Genomic analysis; Neurotoxicity; Statistical analysis; TCDD; Telencephalon; Signal transduction DO - http://dx.doi.org/10.1016/j.reprotox.2009.05.067 ER - TY - JOUR T1 - Squelching glioblastoma stem cells by targeting REST for proteasomal degradation AN - 21070141; 11141777 AB - Glioblastoma brain tumors harbor a small population of cancer stem cells that are resistant to conventional chemotherapeutic and radiation treatments, and are believed responsible for tumor recurrence and mortality. The identification of the epigenetic molecular mechanisms that control self-renewal of glioblastoma stem cells will foster development of targeted therapeutic approaches. The transcriptional repressor REST, best known for its role in controlling cell fate decisions in neural progenitor cells, may also be crucial for cancer stem cell self-renewal. Two novel mechanisms for regulating the stability of REST have recently been revealed: these involve the telomere-binding protein TRF2 and the ubiquitin E3 ligase SCF beta -TrCP. Reduced TRF2 binding to REST, and increased SCF beta -TrCP activity, target REST for proteasomal degradation and thereby inhibit cancer stem cell proliferation. Neurological side effects of treatments that target REST and TRF2 may be less severe than conventional brain tumor treatments because postmitotic neurons do not express REST and have relatively stable telomeres. JF - Trends in Neurosciences AU - Zhang, P AU - Lathia, J D AU - Flavahan, WA AU - Rich, J N AU - Mattson, M P AD - National Institute on Aging Intramural Research Program, Baltimore, MD, zhangpe@grc.nia.nih.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 559 EP - 565 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 32 IS - 11 SN - 0166-2236, 0166-2236 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Mortality KW - Glioblastoma KW - Molecular modelling KW - TRF2 protein KW - proteasomes KW - Transcription KW - Cancer KW - Ubiquitin-protein ligase KW - Brain tumors KW - Stem cells KW - Radiation KW - epigenetics KW - Reviews KW - Neurons KW - Telomere-binding protein KW - Cell fate KW - Neural stem cells KW - Repressors KW - Side effects KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21070141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Neurosciences&rft.atitle=Squelching+glioblastoma+stem+cells+by+targeting+REST+for+proteasomal+degradation&rft.au=Zhang%2C+P%3BLathia%2C+J+D%3BFlavahan%2C+WA%3BRich%2C+J+N%3BMattson%2C+M+P&rft.aulast=Zhang&rft.aufirst=P&rft.date=2009-11-01&rft.volume=32&rft.issue=11&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Trends+in+Neurosciences&rft.issn=01662236&rft_id=info:doi/10.1016%2Fj.tins.2009.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Glioblastoma; Mortality; TRF2 protein; proteasomes; Transcription; Cancer; Ubiquitin-protein ligase; Brain tumors; Stem cells; Radiation; epigenetics; Neurons; Reviews; Telomere-binding protein; Cell fate; Repressors; Neural stem cells; Side effects DO - http://dx.doi.org/10.1016/j.tins.2009.07.005 ER - TY - JOUR T1 - The Developmental Significance of Adolescent Romantic Relationships: Parent and Peer Predictors of Engagement and Quality at Age 15 AN - 204523561; 19779806 AB - From a longitudinal sample (n = 957; 49.9% male; 77.3% White/non-Hispanic) of participants studied from infancy through age 15, adolescents' depth of engagement in, and quality of romantic relationships were predicted from early and contemporaneous parent-child interactive quality and peer social competence. High quality maternal parenting and peer experiences prior to and during adolescence tended to be negatively associated with the depth of engagement in this domain for the full sample, yet positively associated with the quality of adolescents' romantic relationships for the sub-set of individuals currently dating at age 15. Results reconcile contrasting views of the origins of romantic relationship engagement and quality and the positive versus negative developmental salience of romantic relationships in adolescence. [PUBLICATION ABSTRACT] JF - Journal of Youth and Adolescence AU - Roisman, Glenn I AU - Booth-LaForce, Cathryn AU - Cauffman, Elizabeth AU - Spieker, Susan Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1294 EP - 303 CY - New York PB - Springer Science & Business Media VL - 38 IS - 10 SN - 00472891 KW - Psychology KW - Parents & parenting KW - Quality KW - Hypotheses KW - Friendship KW - Prospective Studies KW - Sex Factors KW - Mother-Child Relations KW - Humans KW - Interpersonal Relations KW - Adolescent KW - Male KW - Female KW - Courtship -- psychology KW - Adolescent Behavior -- psychology KW - Adolescent Development KW - Peer Group KW - Parents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/204523561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chongqing+Daxue+Xuebao+%28Ziran+Kexue+Ban%29+%2F+Journal+of+Chongqing+University+%28Natural+Science+Edition%29&rft.atitle=Remote+control+system+based+on+low+voltage+power+line+communication&rft.au=Zhong%2C+Yuan-Chang%3BLiu%2C+Yong%3BLi%2C+Fei%3BLi%2C+Xiu-Zhen&rft.aulast=Zhong&rft.aufirst=Yuan-Chang&rft.date=2010-02-01&rft.volume=33&rft.issue=2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Chongqing+Daxue+Xuebao+%28Ziran+Kexue+Ban%29+%2F+Journal+of+Chongqing+University+%28Natural+Science+Edition%29&rft.issn=1000582X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Springer Science & Business Media Nov 2009 N1 - Document feature - Tables; References N1 - Last updated - 2014-07-26 N1 - CODEN - JYADA6 ER - TY - JOUR T1 - Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. AN - 733607186; 19734146 AB - We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germinal center B cells and in lymphomas derived from germinal center B cells such as large diffuse B cell lymphomas. In cell lines, SLIP-GC is expressed in lymphomas that express activation-induced deaminase (AID) and that likely undergo somatic hypermutation. SLIP-GC is a nuclear protein, and it localizes to replication factories. Reduction of SLIP-GC levels in the Burkitt lymphoma cell line Raji and in non-Hodgkin lymphoma cell lines resulted in an increase in DNA breaks and apoptosis that was AID-dependent, as simultaneous reduction of AID abrogated the deleterious effects of SLIP-GC reduction. These results strongly suggest that SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AID-dependent mechanism. JF - The Journal of biological chemistry AU - Richter, Kathleen AU - Brar, Sukhdev AU - Ray, Madhumita AU - Pisitkun, Prapaporn AU - Bolland, Silvia AU - Verkoczy, Laurent AU - Diaz, Marilyn AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/10/30/ PY - 2009 DA - 2009 Oct 30 SP - 30652 EP - 30661 VL - 284 IS - 44 KW - Neoplasm Proteins KW - 0 KW - Nuclear Proteins KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - SLIP-GC protein, human KW - Index Medicus KW - Apoptosis KW - DNA Damage KW - Humans KW - Cell Line, Tumor KW - Tissue Distribution KW - Nuclear Proteins -- analysis KW - GTP Phosphohydrolases -- physiology KW - B-Lymphocytes -- pathology KW - B-Lymphocytes -- chemistry KW - Germinal Center -- chemistry KW - Cytidine Deaminase -- analysis KW - Lymphoma, B-Cell -- pathology KW - GTP Phosphohydrolases -- analysis KW - Lymphoma, B-Cell -- chemistry KW - Germinal Center -- pathology KW - Nuclear Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733607186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Yu%2C+Bai+Tian&rft.aulast=Yu&rft.aufirst=Bai&rft.date=2006-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Design+of+Lighting+Control+System+Based+on+Power+Line+Communication&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1982 Sep;129(3):1336-42 [6286763] Immunology. 2009 Jan;126(1):102-13 [18624728] J Natl Cancer Inst. 1990 Mar 21;82(6):501-9 [2313723] J Exp Med. 1991 Jun 1;173(6):1407-19 [2033369] Cell. 1991 Dec 20;67(6):1121-9 [1760840] Nat Genet. 1995 Aug;10(4):369-71 [7670480] Genomics. 1996 Apr 1;33(1):151-2 [8617505] Methods Enzymol. 1996;266:131-41 [8743682] Nat Genet. 1997 Jun;16(2):161-70 [9171827] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Int Rev Immunol. 1999;18(4):381-403 [10626250] Trends Genet. 2000 Mar;16(3):103-6 [10689348] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Cell. 2000 Sep 1;102(5):553-63 [11007474] Cell. 2000 Sep 1;102(5):565-75 [11007475] J Cell Biochem. 2001;81(1):56-67 [11180397] Nature. 2001 Jul 19;412(6844):341-6 [11460166] Nat Immunol. 2002 Sep;3(9):815-21 [12145648] Microbiology. 2002 Nov;148(Pt 11):3539-52 [12427945] J Biol Chem. 2004 Jun 18;279(25):26395-401 [15087440] Nature. 1970 Dec 12;228(5276):1045-7 [5483159] Proc Int Conf Intell Syst Mol Biol. 1997;5:147-52 [9322029] Immunol Today. 1998 Nov;19(11):511-4 [9818545] Eur J Haematol. 1999 Sep;63(3):180-91 [10485273] Lancet. 1964 Feb 1;1(7327):238-40 [14086209] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W116-20 [15980438] Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W362-5 [16845026] Mol Immunol. 2007 Apr;44(10):2659-66 [17240451] J Immunol. 2007 Jun 1;178(11):7422-31 [17513793] Nat Genet. 2008 Jan;40(1):108-12 [18066064] Nature. 1990 Feb 1;343(6257):437-41 [2137203] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.014506 ER - TY - CPAPER T1 - Immunization of HIV-Infected Children T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42082017; 5518336 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Siberry, George Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Children KW - Immunization KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42082017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Immunization+of+HIV-Infected+Children&rft.au=Siberry%2C+George&rft.aulast=Siberry&rft.aufirst=George&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complications of Norovirus after Hematopoietic Stem Cell Transplant T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42080382; 5518595 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Cuellar-Rodriguez, Jennifer AU - Williams, Kirsten AU - Pavletic, Steven AU - Gea-Banacloche, Juan Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Stem cells KW - Complications KW - Transplants KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42080382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Complications+of+Norovirus+after+Hematopoietic+Stem+Cell+Transplant&rft.au=Cuellar-Rodriguez%2C+Jennifer%3BWilliams%2C+Kirsten%3BPavletic%2C+Steven%3BGea-Banacloche%2C+Juan&rft.aulast=Cuellar-Rodriguez&rft.aufirst=Jennifer&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV Disease Pathogenesis: Immune Activation and the GI Tract T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42080013; 5518105 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Douek, Danny Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Human immunodeficiency virus KW - Immune response KW - Gastrointestinal tract KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42080013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=HIV+Disease+Pathogenesis%3A+Immune+Activation+and+the+GI+Tract&rft.au=Douek%2C+Danny&rft.aulast=Douek&rft.aufirst=Danny&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biosafety Preparedness: Stories from the Front Line T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42071091; 5518251 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Risi, Jr., George AU - Kortepeter, Mark Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42071091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Biosafety+Preparedness%3A+Stories+from+the+Front+Line&rft.au=Risi%2C+Jr.%2C+George%3BKortepeter%2C+Mark&rft.aulast=Risi&rft.aufirst=Jr.&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevention and Treatment of OIs T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42070712; 5517971 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Masur, Henry Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Prevention+and+Treatment+of+OIs&rft.au=Masur%2C+Henry&rft.aulast=Masur&rft.aufirst=Henry&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Expanding Spectrum of Systemic Autoinflammatory Diseases T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42070548; 5518275 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Aksentijevich, Ivona Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=The+Expanding+Spectrum+of+Systemic+Autoinflammatory+Diseases&rft.au=Aksentijevich%2C+Ivona&rft.aulast=Aksentijevich&rft.aufirst=Ivona&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAT3 Mutation and Human Infectious Diseases T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42070462; 5518008 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Milner, Joshua Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Mutation KW - Stat3 protein KW - Infectious diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=STAT3+Mutation+and+Human+Infectious+Diseases&rft.au=Milner%2C+Joshua&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophils and Innate Immunity to Leishmania T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42068014; 5518007 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Sacks, David Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Immunity KW - Leukocytes (neutrophilic) KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42068014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Neutrophils+and+Innate+Immunity+to+Leishmania&rft.au=Sacks%2C+David&rft.aulast=Sacks&rft.aufirst=David&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Agents and Mechanisms of Immune Suppression T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42067785; 5517937 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Gea-Banacloche, Juan Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3A&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IEEE+Transactions+on+Power+Delivery&rft.atitle=TWACS%29%2C+a+power+line+communication+technology+for+power+distribution+network+control+and+monitoring.&rft.au=Mak%2C+S+T&rft.aulast=Mak&rft.aufirst=S&rft.date=1986-01-01&rft.volume=PWRD-1&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Power+Delivery&rft.issn=08858977&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Diagnostics in Bio-Defense - Microarrays and Lab-on-a-Chip Technologies T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42067602; 5517997 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Rasooly, Avraham Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Technology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Rapid+Diagnostics+in+Bio-Defense+-+Microarrays+and+Lab-on-a-Chip+Technologies&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mobile Genetic Element-Encoded Phenolsoluble Modulin Links Virulence to Antibiotic Resistance in Staphylococcus T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42067459; 5518157 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Otto, Michael Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Antibiotic resistance KW - Virulence KW - Staphylococcus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Mobile+Genetic+Element-Encoded+Phenolsoluble+Modulin+Links+Virulence+to+Antibiotic+Resistance+in+Staphylococcus&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Skin is a Microbiological Zoo T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42067152; 5517930 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Segre, Julie Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Skin+is+a+Microbiological+Zoo&rft.au=Segre%2C+Julie&rft.aulast=Segre&rft.aufirst=Julie&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Locks" to Salvage Infected IV Lines T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42065354; 5518194 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - O'Grady, Naomi Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=%22Locks%22+to+Salvage+Infected+IV+Lines&rft.au=O%27Grady%2C+Naomi&rft.aulast=O%27Grady&rft.aufirst=Naomi&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Case-Based "Non-Infectious" Diseases that Mimic Infections T2 - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AN - 42064077; 5517983 JF - 47th Annual Meeting of the Infectious Diseases Society of America (IDSA 2009) AU - Goldbach-Mansky, Raphaela Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 KW - Infection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42064077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.atitle=Case-Based+%22Non-Infectious%22+Diseases+that+Mimic+Infections&rft.au=Goldbach-Mansky%2C+Raphaela&rft.aulast=Goldbach-Mansky&rft.aufirst=Raphaela&rft.date=2009-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.idsociety.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID =15527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - An Ancient Gauge for Iron AN - 21204979; 11172933 AB - Mammalian cells must manage the import, export, and sequestration of iron to achieve the cytosolic concentrations needed to support the synthesis of iron-binding proteins and prevent unfavorable iron-dependent oxidation events. Key to this maintenance are the iron regulatory proteins IRP1 and IRP2, which respond to the cytosolic iron pool by binding to target mRNA and regulating the synthesis of iron metabolism proteins (1-3). On pages 718 and 722 of this issue, Vashisht et al. and Salahudeen et al. (4, 5) report that human cells gauge cellular iron and concomitantly alter the activity of IRPs through a mechanism that depends on the protein FBXL5. FBXL5 senses iron through an evolutionarily conserved hemerythrin domain that is related to a family of iron- and oxygen-binding proteins in bacteria and invertebrates. JF - Science (Washington) AU - Rouault, Tracey A AD - Molecular Medicine Program, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA., trou@helix.nih.gov Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 SP - 676 EP - 677 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 326 IS - 5953 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Evolution KW - Iron KW - J 02410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21204979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Review&rft.atitle=Norway+and+America%3A+Looking+at+Each+Other&rft.au=Bryn%2C+Steinar&rft.aulast=Bryn&rft.aufirst=Steinar&rft.date=1988-07-01&rft.volume=76&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Review&rft.issn=0098857X&rft_id=info:doi/ L2 - http://www.sciencemag.org/cgi/reprint/326/5953/676.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Iron DO - http://dx.doi.org/10.1126/science.1181938 ER - TY - CPAPER T1 - Patient-Reported Outcomes Measurement Information System (PROMIS): Advancing the Science of Health-Related Quality of Life Assessment T2 - 16th Annual Conference of the International Society for Quality of Life Research AN - 42123106; 5540867 JF - 16th Annual Conference of the International Society for Quality of Life Research AU - Reeve, Bryce Y1 - 2009/10/28/ PY - 2009 DA - 2009 Oct 28 KW - Quality of life KW - Information systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42123106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.atitle=Patient-Reported+Outcomes+Measurement+Information+System+%28PROMIS%29%3A+Advancing+the+Science+of+Health-Related+Quality+of+Life+Assessment&rft.au=Reeve%2C+Bryce&rft.aulast=Reeve&rft.aufirst=Bryce&rft.date=2009-10-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.isoqol.org/2009conference/pdf/2009ConferenceProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Change in Health Related Quality of Life among Breast Cancer Survivors across the Cancer Continuum T2 - 16th Annual Conference of the International Society for Quality of Life Research AN - 42122536; 5540846 JF - 16th Annual Conference of the International Society for Quality of Life Research AU - Smith, Ashley AU - Reeve, Bryce AU - Hays, Ron AU - Arora, Neeraj AU - Alfano, Catherine AU - Clauser, Steven Y1 - 2009/10/28/ PY - 2009 DA - 2009 Oct 28 KW - Breast cancer KW - Quality of life KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.atitle=Change+in+Health+Related+Quality+of+Life+among+Breast+Cancer+Survivors+across+the+Cancer+Continuum&rft.au=Smith%2C+Ashley%3BReeve%2C+Bryce%3BHays%2C+Ron%3BArora%2C+Neeraj%3BAlfano%2C+Catherine%3BClauser%2C+Steven&rft.aulast=Smith&rft.aufirst=Ashley&rft.date=2009-10-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.isoqol.org/2009conference/pdf/2009ConferenceProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of Quality of Care from Cancer Survivors' Perspective T2 - 16th Annual Conference of the International Society for Quality of Life Research AN - 42119504; 5540845 JF - 16th Annual Conference of the International Society for Quality of Life Research AU - Arora, Neeraj AU - Reeve, Bryce AU - Hays, Ron AU - Clauser, Steven AU - Oakley-Girvan, Ingrid Y1 - 2009/10/28/ PY - 2009 DA - 2009 Oct 28 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42119504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.atitle=Assessment+of+Quality+of+Care+from+Cancer+Survivors%27+Perspective&rft.au=Arora%2C+Neeraj%3BReeve%2C+Bryce%3BHays%2C+Ron%3BClauser%2C+Steven%3BOakley-Girvan%2C+Ingrid&rft.aulast=Arora&rft.aufirst=Neeraj&rft.date=2009-10-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Conference+of+the+International+Society+for+Quality+of+Life+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.isoqol.org/2009conference/pdf/2009ConferenceProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Mechanisms of Susceptibility to Oxidant- Induced Lung Disease T2 - 4th International Conference on Oxidative/Nitrosative Stress and Disease AN - 42071846; 5508171 JF - 4th International Conference on Oxidative/Nitrosative Stress and Disease AU - Kleeberger, Steven Y1 - 2009/10/28/ PY - 2009 DA - 2009 Oct 28 KW - Lung diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42071846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+International+Conference+on+Oxidative%2FNitrosative+Stress+and+Disease&rft.atitle=Genetic+Mechanisms+of+Susceptibility+to+Oxidant-+Induced+Lung+Disease&rft.au=Kleeberger%2C+Steven&rft.aulast=Kleeberger&rft.aufirst=Steven&rft.date=2009-10-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+International+Conference+on+Oxidative%2FNitrosative+Stress+and+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.nyas.org/asset.axd?id=1bf436aa-52be-4d93-9c4e-5d40e5eea688& t=633882031263530000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. AN - 733927741; 19820169 AB - The kinetics and magnitude of cytokine gene expression are tightly regulated to elicit a balanced response to pathogens and result from integrated changes in transcription and mRNA stability. Yet, how a single microbial stimulus induces peak transcription of some genes (TNFalpha) within minutes whereas others (IP-10) require hours remains unclear. Here, we dissect activation of several lipopolysaccharide (LPS)-inducible genes in macrophages, an essential cell type mediating inflammatory response in mammals. We show that a key difference between the genes is the step of the transcription cycle at which they are regulated. Specifically, at TNFalpha, RNA Polymerase II initiates transcription in resting macrophages, but stalls near the promoter until LPS triggers rapid and transient release of the negative elongation factor (NELF) complex and productive elongation. In contrast, no NELF or polymerase is detectible near the IP-10 promoter before induction, and LPS-dependent polymerase recruitment is rate limiting for transcription. We further demonstrate that this strategy is shared by other immune mediators and is independent of the inducer and signaling pathway responsible for gene activation. Finally, as a striking example of evolutionary conservation, the Drosophila homolog of the TNFalpha gene, eiger, displayed all of the hallmarks of NELF-dependent polymerase stalling. We propose that polymerase stalling ensures the coordinated, timely activation the inflammatory gene expression program from Drosophila to mammals. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Adelman, Karen AU - Kennedy, Megan A AU - Nechaev, Sergei AU - Gilchrist, Daniel A AU - Muse, Ginger W AU - Chinenov, Yurii AU - Rogatsky, Inez AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. adelmank@niehs.nih.gov Y1 - 2009/10/27/ PY - 2009 DA - 2009 Oct 27 SP - 18207 EP - 18212 VL - 106 IS - 43 KW - Drosophila Proteins KW - 0 KW - Lipopolysaccharides KW - Membrane Proteins KW - Transcription Factors KW - Tumor Necrosis Factor-alpha KW - eiger protein, Drosophila KW - negative elongation factor KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Phosphorylation KW - Lipopolysaccharides -- immunology KW - Transcription Factors -- metabolism KW - Mice KW - Evolution, Molecular KW - Cell Line KW - RNA Polymerase II -- metabolism KW - Macrophages -- immunology KW - Drosophila melanogaster -- genetics KW - Membrane Proteins -- metabolism KW - Tumor Necrosis Factor-alpha -- immunology KW - Drosophila melanogaster -- metabolism KW - Gene Expression Regulation KW - Drosophila Proteins -- genetics KW - Membrane Proteins -- genetics KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Drosophila Proteins -- metabolism KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733927741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Immediate+mediators+of+the+inflammatory+response+are+poised+for+gene+activation+through+RNA+polymerase+II+stalling.&rft.au=Adelman%2C+Karen%3BKennedy%2C+Megan+A%3BNechaev%2C+Sergei%3BGilchrist%2C+Daniel+A%3BMuse%2C+Ginger+W%3BChinenov%2C+Yurii%3BRogatsky%2C+Inez&rft.aulast=Adelman&rft.aufirst=Karen&rft.date=2009-10-27&rft.volume=106&rft.issue=43&rft.spage=18207&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0910177106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-24 N1 - Date created - 2009-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2007 Jun 15;129(6):1111-23 [17574024] Mol Cell. 2006 Aug 4;23(3):297-305 [16885020] J Biol Chem. 2007 Jul 27;282(30):21901-12 [17548348] Science. 2007 Aug 3;317(5838):675-8 [17673665] J Immunol. 2007 Sep 1;179(5):2686-9 [17709479] Nat Genet. 2007 Dec;39(12):1512-6 [17994019] Nat Genet. 2007 Dec;39(12):1507-11 [17994021] Biochem Soc Trans. 2008 Jun;36(Pt 3):491-6 [18481987] Genes Dev. 2008 Jul 15;22(14):1921-33 [18628398] Clin Immunol. 2009 Jan;130(1):7-15 [18964303] Immunol Rev. 2008 Dec;226:41-56 [19161415] EMBO J. 2001 Nov 1;20(21):6071-83 [11689447] J Biol Chem. 2001 Nov 9;276(45):42601-9 [11553615] Eur Cytokine Netw. 2002 Jan-Mar;13(1):92-8 [11956026] EMBO J. 2002 Jun 17;21(12):3009-18 [12065414] Mol Cell Biol. 2009 Mar;29(5):1123-33 [19103744] Nat Immunol. 2009 Mar;10(3):281-8 [19198593] Cell. 2007 Jul 13;130(1):77-88 [17632057] Curr Biol. 2002 Jul 23;12(14):1263-8 [12176339] J Exp Med. 2003 Mar 17;197(6):711-23 [12642603] Science. 2003 Jun 6;300(5625):1524-5 [12791976] Rheumatology (Oxford). 2003 May;42 Suppl 2:ii3-10 [12817089] Nat Struct Biol. 2003 Sep;10(9):679-80 [12942140] Nat Med. 2003 Oct;9(10):1245-50 [14520364] Genes Dev. 2004 Sep 1;18(17):2134-46 [15342491] Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14461-6 [15452344] Arthritis Rheum. 1991 Sep;34(9):1125-32 [1930331] Genes Dev. 1992 Nov;6(11):2190-200 [1427079] Cell. 1993 May 7;73(3):457-67 [8387893] Nature. 1993 Aug 26;364(6440):798-802 [8395024] Genes Dev. 1995 Mar 1;9(5):559-72 [7698646] Science. 1998 Aug 14;281(5379):1001-5 [9703499] Cell. 1999 Apr 2;97(1):41-51 [10199401] Cold Spring Harb Symp Quant Biol. 1998;63:347-56 [10384299] Nucleic Acids Res. 2005;33(4):1269-79 [15741180] J Immunol. 2005 Jul 1;175(1):461-8 [15972680] Curr Opin Immunol. 2005 Aug;17(4):338-44 [15950447] EMBO J. 2006 Jan 11;25(1):108-17 [16362036] Cancer Res. 2006 Feb 1;66(3):1346-53 [16452188] Genes Dev. 2006 Feb 1;20(3):282-96 [16452502] Mol Cell Biol. 2006 Aug;26(16):6094-104 [16880520] Cell. 2009 Jul 10;138(1):129-45 [19596240] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0910177106 ER - TY - CPAPER T1 - Strategies for Accelerating Forward and Backprojection in List-Mode OSEM PET Reconstruction Using GPUs T2 - 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference AN - 42065384; 5514483 JF - 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference AU - Dieckmann, W AU - Thada, S AU - Barker, W Y1 - 2009/10/25/ PY - 2009 DA - 2009 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference&rft.atitle=Strategies+for+Accelerating+Forward+and+Backprojection+in+List-Mode+OSEM+PET+Reconstruction+Using+GPUs&rft.au=Dieckmann%2C+W%3BThada%2C+S%3BBarker%2C+W&rft.aulast=Dieckmann&rft.aufirst=W&rft.date=2009-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.nss-mic.org/2009/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A GPU-Accelerated Implementation of the MOLAR PET Reconstruction Package T2 - 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference AN - 42064293; 5514484 JF - 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference AU - Barker, W AU - Thada, S AU - Dieckmann, W Y1 - 2009/10/25/ PY - 2009 DA - 2009 Oct 25 KW - Packaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42064293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference&rft.atitle=A+GPU-Accelerated+Implementation+of+the+MOLAR+PET+Reconstruction+Package&rft.au=Barker%2C+W%3BThada%2C+S%3BDieckmann%2C+W&rft.aulast=Barker&rft.aufirst=W&rft.date=2009-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.nss-mic.org/2009/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A comprehensive analysis of sequence variants and putative disease-causing mutations in photoreceptor-specific nuclear receptor NR2E3. AN - 734132617; 19898638 AB - The photoreceptor-specific orphan nuclear receptor NR2E3 is a key regulator of transcriptional events during photoreceptor differentiation in mammalian retina. Mutations in NR2E3 are associated with enhanced S-cone syndrome and related retinal phenotypes that reveal characteristic excess of S-cone function. This study was undertaken to determine biochemical as well as functional consequences of reported sequence variants and disease-causing mutations in NR2E3. Twenty-five different mutations in the wild-type NR2E3 expression construct were generated by site-directed mutagenesis and performed nuclear localization, gel-shift, rhodopsin promoter activity assays, and co-immunoprecipitation in cultured mammalian cells. Of the 25 mutant proteins, 15 mislocalize at least partially to the cytoplasm. Eight of the nine changes in the DNA-binding domain (DBD) and 12 of the 14 mutations in the ligand-binding domain (LBD) of NR2E3 exhibited reduced DNA-binding and transcriptional activation of the rhodopsin promoter. Moreover, these mutations dramatically altered the interaction of NR2E3 with NRL as well as with CRX. Two NR2E3 variants between DBD and LBD showed no effect on any biochemical or functional parameter tested. These data provide a better understanding of sequence variants, validate disease-causing mutations, and demonstrate the significance of DBD and LBD in mediating NR2E3 function. These studies contribute to molecular mechanisms underlying retinal phenotypes caused by NR2E3 mutations. JF - Molecular vision AU - Kanda, Atsuhiro AU - Swaroop, Anand AD - Neurobiology Neurodegeneration and Repair Laboratory (N-NRL), National Eye Institute, NIH, Bethesda, MD 20892, USA. kandaa@nei.nih.gov Y1 - 2009/10/24/ PY - 2009 DA - 2009 Oct 24 SP - 2174 EP - 2184 VL - 15 KW - Basic-Leucine Zipper Transcription Factors KW - 0 KW - Eye Proteins KW - Homeodomain Proteins KW - Mutant Proteins KW - NR2E3 protein, human KW - NRL protein, human KW - Orphan Nuclear Receptors KW - Trans-Activators KW - cone rod homeobox protein KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Trans-Activators -- metabolism KW - Animals KW - DNA -- metabolism KW - Eye Proteins -- metabolism KW - Humans KW - Transcription, Genetic KW - Amino Acid Sequence KW - Protein Binding KW - Base Sequence KW - Basic-Leucine Zipper Transcription Factors -- metabolism KW - Homeodomain Proteins -- metabolism KW - Molecular Sequence Data KW - Transcriptional Activation -- genetics KW - Subcellular Fractions -- metabolism KW - Cell Line KW - Protein Transport KW - Mutant Proteins -- metabolism KW - Orphan Nuclear Receptors -- genetics KW - Orphan Nuclear Receptors -- chemistry KW - Mutation -- genetics KW - Retinal Diseases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734132617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+vision&rft.atitle=A+comprehensive+analysis+of+sequence+variants+and+putative+disease-causing+mutations+in+photoreceptor-specific+nuclear+receptor+NR2E3.&rft.au=Kanda%2C+Atsuhiro%3BSwaroop%2C+Anand&rft.aulast=Kanda&rft.aufirst=Atsuhiro&rft.date=2009-10-24&rft.volume=15&rft.issue=&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Molecular+vision&rft.issn=1090-0535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-30 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1996 Nov 15;24(22):4379-86 [8948627] Nat Struct Biol. 1996 Jan;3(1):87-94 [8548460] EMBO J. 1997 Sep 15;16(18):5697-709 [9312028] Am J Hum Genet. 1998 Nov;63(5):1307-15 [9792858] Nat Genet. 1999 Apr;21(4):355-6 [10192380] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4814-9 [10220376] Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17819-24 [15591106] J Neurosci. 2005 Jan 5;25(1):118-29 [15634773] Trends Genet. 2005 Feb;21(2):103-10 [15661356] Hum Mol Genet. 2005 Mar 15;14(6):747-64 [15689355] J Mol Endocrinol. 2005 Dec;35(3):449-64 [16326832] Ophthalmology. 2005 Dec;112(12):2115 [16225923] PLoS Genet. 2005 Aug;1(2):e11 [16110338] Hum Mol Genet. 2006 Jul 1;15(13):2146-56 [16723373] Hum Mol Genet. 2006 Sep 1;15(17):2588-602 [16868010] Vis Neurosci. 2006 Nov-Dec;23(6):917-29 [17266784] Mol Vis. 2007;13:594-601 [17438525] Hum Mutat. 2007 Jun;28(6):589-98 [17335001] Am J Hum Genet. 2007 Jul;81(1):147-57 [17564971] Am J Ophthalmol. 2007 Jul;144(1):157-9 [17601449] Mol Vis. 2007;13:1970-5 [17982421] Clin Genet. 2008 Apr;73(4):360-6 [18294254] Invest Ophthalmol Vis Sci. 2008 May;49(5):2082-93 [18436841] Brain Res. 2008 Oct 21;1236:16-29 [18294621] Arch Ophthalmol. 2009 Jan;127(1):71-5 [19139342] Hum Mutat. 2009 Mar;30(3):342-51 [19006237] Nat Genet. 2000 Feb;24(2):127-31 [10655056] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5551-6 [10805811] Hum Genet. 2000 Sep;107(3):276-84 [11071390] Hum Mol Genet. 2001 Aug 1;10(16):1619-26 [11487564] Hum Mol Genet. 2002 May 15;11(10):1219-27 [12015282] Arch Ophthalmol. 2003 Sep;121(9):1316-23 [12963616] Hum Mol Genet. 2004 Aug 1;13(15):1563-75 [15190009] Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2807-12 [15277507] Acta Ophthalmol Scand. 2004 Oct;82(5):616-22 [15453866] Hum Mutat. 2004 Nov;24(5):439 [15459973] Cell. 1988 Dec 2;55(5):899-906 [3191531] Cell. 1989 Jun 30;57(7):1139-46 [2500251] Doc Ophthalmol. 1989 Mar;71(3):265-9 [2789128] Am J Ophthalmol. 1991 Apr 15;111(4):446-53 [2012146] Exp Eye Res. 1991 Nov;53(5):685-90 [1743268] Nature. 1995 Jun 1;375(6530):377-82 [7760929] Vision Res. 1995 May;35(10):1473-81 [7645276] Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2381-7 [7591627] Nature. 1995 Dec 14;378(6558):681-9 [7501014] Curr Opin Cell Biol. 1997 Apr;9(2):222-32 [9069256] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape leukemia virus. AN - 734089835; 19717569 AB - Infection of a host cell by a retrovirus requires an initial interaction with a cellular receptor. For numerous gammaretroviruses, such as the gibbon ape leukemia virus, woolly monkey virus, feline leukemia virus subgroup B, feline leukemia virus subgroup T, and 10A1 murine leukemia virus, this receptor is the human type III sodium-dependent inorganic phosphate transporter, SLC20A1, formerly known as PiT1. Understanding the critical receptor functionalities and interactions with the virus that lead to successful infection requires that we first know the surface structure of the cellular receptor. Previous molecular modeling from the protein sequence, and limited empirical data, predicted a protein with 10 transmembrane helices. Here we undertake the biochemical approach of substituted cysteine accessibility mutagenesis to resolve the topology of this receptor in live cells. We discover that there are segments of the protein that are unexpectedly exposed to the outside milieu. By using information determined by substituted cysteine accessibility mutagenesis to set constraints in HMMTOP, a hidden Markov model-based transmembrane topology prediction method, we now propose a comprehensive topological model for SLC20A1, a transmembrane protein with 12 transmembrane helices and 7 extracellular regions, that varies from previous models and should permit approaches that define both virus interaction and transport function. JF - The Journal of biological chemistry AU - Farrell, Karen B AU - Tusnady, Gabor E AU - Eiden, Maribeth V AD - Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA. Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 SP - 29979 EP - 29987 VL - 284 IS - 43 KW - Receptors, Virus KW - 0 KW - Sodium-Phosphate Cotransporter Proteins, Type III KW - leukemia virus receptor, gibbon ape KW - Index Medicus KW - Animals KW - Protein Structure, Tertiary -- genetics KW - Hylobates KW - Humans KW - Cats KW - Biological Transport KW - Mice KW - Protein Structure, Secondary -- genetics KW - Cell Line KW - Mutagenesis KW - Sodium-Phosphate Cotransporter Proteins, Type III -- metabolism KW - Sodium-Phosphate Cotransporter Proteins, Type III -- genetics KW - Sodium-Phosphate Cotransporter Proteins, Type III -- chemistry KW - Models, Molecular KW - Receptors, Virus -- metabolism KW - Receptors, Virus -- genetics KW - Receptors, Virus -- chemistry KW - Leukemia Virus, Gibbon Ape UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734089835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=New+structural+arrangement+of+the+extracellular+regions+of+the+phosphate+transporter+SLC20A1%2C+the+receptor+for+gibbon+ape+leukemia+virus.&rft.au=Farrell%2C+Karen+B%3BTusnady%2C+Gabor+E%3BEiden%2C+Maribeth+V&rft.aulast=Farrell&rft.aufirst=Karen&rft.date=2009-10-23&rft.volume=284&rft.issue=43&rft.spage=29979&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.022566 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 1998 Sep;21(3):623-32 [9768848] J Virol. 1997 Oct;71(10):8078-81 [9311908] Methods. 2005 Jun;36(2):148-71 [15894490] Protein Sci. 2005 Jul;14(7):1723-8 [15987901] Methods. 2007 Apr;41(4):439-50 [17367716] Am J Physiol Renal Physiol. 2007 Sep;293(3):F643-54 [17581921] Nucleic Acids Res. 2008 Jan;36(Database issue):D234-9 [17921502] J Mol Biol. 2001 Jan 19;305(3):567-80 [11152613] J Virol. 2001 Jun;75(12):5584-92 [11356966] J Struct Biol. 2001 May-Jun;134(2-3):204-18 [11551180] Bioinformatics. 2001 Sep;17(9):849-50 [11590105] J Virol. 2002 Aug;76(15):7683-93 [12097582] J Virol. 2003 May;77(10):5926-32 [12719585] J Virol. 2004 Jan;78(2):595-602 [14694091] J Mol Biol. 2004 May 14;338(5):1027-36 [15111065] J Virol. 1984 Nov;52(2):695-8 [6092693] Cell Growth Differ. 1990 Mar;1(3):119-27 [2078500] J Virol. 1993 Nov;67(11):6733-6 [8411375] Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1168-72 [8302848] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7071-5 [8041748] J Biol Chem. 1994 Oct 14;269(41):25426-31 [7929240] J Virol. 1994 Dec;68(12):8270-6 [7966619] J Virol. 1995 Jan;69(1):534-7 [7983751] J Biol Chem. 1995 Jan 13;270(2):843-8 [7822320] J Virol. 1996 Jan;70(1):321-6 [8523543] J Virol. 1996 Feb;70(2):1080-5 [8551566] Kidney Int. 1996 Apr;49(4):959-63 [8691744] Neuropharmacology. 1996;35(7):797-804 [8938712] J Virol. 1997 Oct;71(10):7619-22 [9311843] J Mol Biol. 1998 Oct 23;283(2):489-506 [9769220] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.022566 ER - TY - CPAPER T1 - Successful Immunotherapy with Il-2/Anti-cd40 Directly Coincides with Specific Chemokine-Mediated Mitigation of an Immunosuppressive Tumor Microenvironment T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42121068; 5524844 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Weiss, Jonathan AU - Back, Timothy AU - Scarzello, Anthony AU - Subleski, Jeff AU - Hall, Veronica AU - Stauffer, Jimmy AU - Micic, Dejan AU - Alderson, Kory AU - Murphy, William AU - Wiltrout, Robert Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Immunotherapy KW - Tumors KW - Mitigation KW - Microenvironments KW - Interleukin 2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42121068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Successful+Immunotherapy+with+Il-2%2FAnti-cd40+Directly+Coincides+with+Specific+Chemokine-Mediated+Mitigation+of+an+Immunosuppressive+Tumor+Microenvironment&rft.au=Weiss%2C+Jonathan%3BBack%2C+Timothy%3BScarzello%2C+Anthony%3BSubleski%2C+Jeff%3BHall%2C+Veronica%3BStauffer%2C+Jimmy%3BMicic%2C+Dejan%3BAlderson%2C+Kory%3BMurphy%2C+William%3BWiltrout%2C+Robert&rft.aulast=Weiss&rft.aufirst=Jonathan&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Race Affects Clinical Responsiveness to Interferon Alpha in a Disease-Dependent Fashion T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42120974; 5524832 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Zoltan Pos1,, AU - Silvia Selleri1,, AU - Spivey, Tara AU - Liu, Hui AU - Worschech, Andrea AU - Sabatino, Marianna AU - Monaco, Alessandro AU - Falus, Andras AU - Wang, Ena AU - Alter, Harvey AU - Marincola, Francesco Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - A-Interferon KW - Races KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42120974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+Power+Systems&rft.atitle=Data+pipeline%2C+or+data+pipedream%3F&rft.au=Nunn%2C+Clive&rft.aulast=Nunn&rft.aufirst=Clive&rft.date=1998-11-01&rft.volume=18&rft.issue=11&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Modern+Power+Systems&rft.issn=02607840&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for cd4 T Cell-Mediated Tumor Regression and the Mechanism of the Subsequent Tumor Immune Escape T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42120881; 5524785 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Friedman, Kevin AU - Yang, James AU - Prieto, Peter AU - Devillier, Laura AU - Rosenberg, Steven AU - Dudley, Mark Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Tumors KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42120881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Evidence+for+cd4+T+Cell-Mediated+Tumor+Regression+and+the+Mechanism+of+the+Subsequent+Tumor+Immune+Escape&rft.au=Friedman%2C+Kevin%3BYang%2C+James%3BPrieto%2C+Peter%3BDevillier%2C+Laura%3BRosenberg%2C+Steven%3BDudley%2C+Mark&rft.aulast=Friedman&rft.aufirst=Kevin&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Inflammation with Il-18/Il-12 or Agalcer Treatment Induces Liver Inkt Cell Apoptosis and Repopulation from Peripheral Tissues, Whereas Chronic Inflammation Ablates Systemic Inkt Cells with Thymic-Dependent Repopulation T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42114240; 5524924 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Subleski, Jeff AU - Hall, Veronica AU - Scarzello, Anthony AU - Wolfe, Thomas AU - Ortaldo, John AU - Hodge, Deborah AU - Weiss, Jon AU - Chan, Tim AU - Wiltrout, Robert Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Repopulation KW - Liver KW - Inflammation KW - Interleukin 18 KW - Apoptosis KW - Hepatocytes KW - Interleukin 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42114240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Acute+Inflammation+with+Il-18%2FIl-12+or+Agalcer+Treatment+Induces+Liver+Inkt+Cell+Apoptosis+and+Repopulation+from+Peripheral+Tissues%2C+Whereas+Chronic+Inflammation+Ablates+Systemic+Inkt+Cells+with+Thymic-Dependent+Repopulation&rft.au=Subleski%2C+Jeff%3BHall%2C+Veronica%3BScarzello%2C+Anthony%3BWolfe%2C+Thomas%3BOrtaldo%2C+John%3BHodge%2C+Deborah%3BWeiss%2C+Jon%3BChan%2C+Tim%3BWiltrout%2C+Robert&rft.aulast=Subleski&rft.aufirst=Jeff&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Therapy with Anti-Angiogenic Agents and Adoptive Cell Therapy (Act) in a Murine Tumor Model T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42105414; 5524801 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Shrimali, Rajeev AU - Theoret, Marc AU - Yu, Zhiya AU - Chinnasamy, Dhanalakshmi AU - Restifo, Nicholas AU - Rosenberg, Steven Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Tumors KW - Animal models KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42105414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Combination+Therapy+with+Anti-Angiogenic+Agents+and+Adoptive+Cell+Therapy+%28Act%29+in+a+Murine+Tumor+Model&rft.au=Shrimali%2C+Rajeev%3BTheoret%2C+Marc%3BYu%2C+Zhiya%3BChinnasamy%2C+Dhanalakshmi%3BRestifo%2C+Nicholas%3BRosenberg%2C+Steven&rft.aulast=Shrimali&rft.aufirst=Rajeev&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circulating Regulatory T Cell Function and Overall Survival in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Poxviral-based Vaccine T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42105324; 5524778 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Vergati, Matteo Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Vaccines KW - Prostate cancer KW - Survival KW - Lymphocytes T KW - Immunoregulation KW - Metastases KW - Cell survival KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42105324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Circulating+Regulatory+T+Cell+Function+and+Overall+Survival+in+Metastatic+Castration-Resistant+Prostate+Cancer+Patients+Treated+with+Poxviral-based+Vaccine&rft.au=Vergati%2C+Matteo&rft.aulast=Vergati&rft.aufirst=Matteo&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleukin-1 Role in Human Th17 Responses, Dendritic Cell Activation, and Epithelial Cell Transformation T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42105073; 5524744 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Trinchieri, Giorgio Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Interleukin 1 KW - Epithelial cells KW - Dendritic cells KW - Lymphocytes T KW - Cell activation KW - Transformation KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42105073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Interleukin-1+Role+in+Human+Th17+Responses%2C+Dendritic+Cell+Activation%2C+and+Epithelial+Cell+Transformation&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Bortezomib-Induced Proteasome Inhibition on Anti-Tumor T Cell Responses in Vivo T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42099662; 5524800 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Shanker, Anil AU - De Kluyver, Rachel AU - Wine, John AU - Sayers, Thomas Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Proteasomes KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42099662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Impact+of+Bortezomib-Induced+Proteasome+Inhibition+on+Anti-Tumor+T+Cell+Responses+in+Vivo&rft.au=Shanker%2C+Anil%3BDe+Kluyver%2C+Rachel%3BWine%2C+John%3BSayers%2C+Thomas&rft.aulast=Shanker&rft.aufirst=Anil&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Tumor Immunity by NKT Cell Subsets T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42098888; 5524742 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Terabe, Masaki Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Tumors KW - Immunity KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42098888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Regulation+of+Tumor+Immunity+by+NKT+Cell+Subsets&rft.au=Terabe%2C+Masaki&rft.aulast=Terabe&rft.aufirst=Masaki&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bortezomib Sensitizes Renal Cancer Cells to Trail-Mediated Apoptosis in Vitro and in Vivo T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42096924; 5524945 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Sayers, Thomas AU - Jacobsen, Kristen AU - Shanker, Anil AU - Brooks, Alan Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Cancer KW - Apoptosis KW - Kidneys KW - Bortezomib KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42096924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Bortezomib+Sensitizes+Renal+Cancer+Cells+to+Trail-Mediated+Apoptosis+in+Vitro+and+in+Vivo&rft.au=Sayers%2C+Thomas%3BJacobsen%2C+Kristen%3BShanker%2C+Anil%3BBrooks%2C+Alan&rft.aulast=Sayers&rft.aufirst=Thomas&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Programming Tumor-Reactive Effector Memory CD8+ T Cells In Vitro Obivates the Requirement for In Vivo Vaccination T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42096020; 5524771 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Klebanoff, Christopher Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Vaccination KW - Memory cells KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Planning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42096020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Programming+Tumor-Reactive+Effector+Memory+CD8%2B+T+Cells+In+Vitro+Obivates+the+Requirement+for+In+Vivo+Vaccination&rft.au=Klebanoff%2C+Christopher&rft.aulast=Klebanoff&rft.aufirst=Christopher&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Modulation of Hepatic and Splenic Dendritic Cell Number and Functions with Systemic Il-12 Therapy T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42094720; 5524814 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Chan, Tim AU - Back, Timothy AU - Subleski, Jeffrey AU - Weiss, Jonathan AU - Ortaldo, John AU - Wiltrout, Robert Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Dendritic cells KW - Interleukin 12 KW - Spleen KW - Liver KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42094720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Differential+Modulation+of+Hepatic+and+Splenic+Dendritic+Cell+Number+and+Functions+with+Systemic+Il-12+Therapy&rft.au=Chan%2C+Tim%3BBack%2C+Timothy%3BSubleski%2C+Jeffrey%3BWeiss%2C+Jonathan%3BOrtaldo%2C+John%3BWiltrout%2C+Robert&rft.aulast=Chan&rft.aufirst=Tim&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adoptive Cell Therapy (Act) Using T Cells Expressing a Chimeric Antigen Receptor for Vascular Endothelial Growth Factor Receptor-2 (Vegfr-2) Promotes Tumor Destruction and Enhances Immunotherapy in Mice T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42094627; 5524782 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Chinnasamy, Dhanalakshmi AU - Yu, Zhiya AU - Theoret, Marc AU - Shrimali, Rajeev AU - Zhao, Yangbing AU - Restifo, Nicholas AU - Rosenberg, Steven Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Immunotherapy KW - Mice KW - Tumors KW - Growth factors KW - Vascular endothelial growth factor receptors KW - Lymphocytes T KW - Antigens KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42094627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Adoptive+Cell+Therapy+%28Act%29+Using+T+Cells+Expressing+a+Chimeric+Antigen+Receptor+for+Vascular+Endothelial+Growth+Factor+Receptor-2+%28Vegfr-2%29+Promotes+Tumor+Destruction+and+Enhances+Immunotherapy+in+Mice&rft.au=Chinnasamy%2C+Dhanalakshmi%3BYu%2C+Zhiya%3BTheoret%2C+Marc%3BShrimali%2C+Rajeev%3BZhao%2C+Yangbing%3BRestifo%2C+Nicholas%3BRosenberg%2C+Steven&rft.aulast=Chinnasamy&rft.aufirst=Dhanalakshmi&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T Cell Delivery of Interleukin-12 to the Tumor Microenvironment Triggers Potent Endogenous Anti-Tumor Responses T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42094535; 5524757 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Kerkar, Sid Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Tumors KW - Microenvironments KW - Lymphocytes T KW - Interleukin 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42094535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=T+Cell+Delivery+of+Interleukin-12+to+the+Tumor+Microenvironment+Triggers+Potent+Endogenous+Anti-Tumor+Responses&rft.au=Kerkar%2C+Sid&rft.aulast=Kerkar&rft.aufirst=Sid&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Responses to Murine T Cell Receptors in Patients Enrolled in Tcr Gene Therapy Trials T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42094028; 5524783 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Davis, Jeremy AU - Theoret, Marc AU - Zheng, Zhili AU - Rosenberg, Steven AU - Morgan, Richard Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - T-cell receptor KW - Clinical trials KW - Gene therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42094028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Immune+Responses+to+Murine+T+Cell+Receptors+in+Patients+Enrolled+in+Tcr+Gene+Therapy+Trials&rft.au=Davis%2C+Jeremy%3BTheoret%2C+Marc%3BZheng%2C+Zhili%3BRosenberg%2C+Steven%3BMorgan%2C+Richard&rft.aulast=Davis&rft.aufirst=Jeremy&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro Anticancer Property of Nbd Peptide through Inhibition of Nf-Kb Activation T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42092107; 5524927 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Ascierto, Maria AU - Gentilcore, Giusy AU - Gravina, Carmela AU - Worschech, Andrea AU - Pos, Zoltan AU - Wang, Richard AU - Natale, Emiliana AU - Capone, Marilena AU - De Maio, Anna AU - Pirozzi, Giuseppe AU - De Martino, Silvana AU - Wang, Ena AU - Marincola, Francesco AU - Ascierto, Paolo Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - NF-B protein KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42092107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=In+Vitro+Anticancer+Property+of+Nbd+Peptide+through+Inhibition+of+Nf-Kb+Activation&rft.au=Ascierto%2C+Maria%3BGentilcore%2C+Giusy%3BGravina%2C+Carmela%3BWorschech%2C+Andrea%3BPos%2C+Zoltan%3BWang%2C+Richard%3BNatale%2C+Emiliana%3BCapone%2C+Marilena%3BDe+Maio%2C+Anna%3BPirozzi%2C+Giuseppe%3BDe+Martino%2C+Silvana%3BWang%2C+Ena%3BMarincola%2C+Francesco%3BAscierto%2C+Paolo&rft.aulast=Ascierto&rft.aufirst=Maria&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ctregs (Circulating Regulatory T Cells) Reduction in Melanoma Patients Treated with Intravenous High-Dose IFNAlpha2b T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42090724; 5524917 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Gentilcore, Giusy AU - Ascierto, Maria AU - Napolitano, Maria AU - Capone, Marilena AU - Simeone, Ester AU - Da Ponte, Antonio AU - Caraco, Corrado AU - Wang, Ena AU - Mozzillo, Nicola AU - Marincola, Francesco AU - Ascierto, Paolo Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Melanoma KW - Lymphocytes T KW - Immunoregulation KW - Intravenous administration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42090724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Ctregs+%28Circulating+Regulatory+T+Cells%29+Reduction+in+Melanoma+Patients+Treated+with+Intravenous+High-Dose+IFNAlpha2b&rft.au=Gentilcore%2C+Giusy%3BAscierto%2C+Maria%3BNapolitano%2C+Maria%3BCapone%2C+Marilena%3BSimeone%2C+Ester%3BDa+Ponte%2C+Antonio%3BCaraco%2C+Corrado%3BWang%2C+Ena%3BMozzillo%2C+Nicola%3BMarincola%2C+Francesco%3BAscierto%2C+Paolo&rft.aulast=Gentilcore&rft.aufirst=Giusy&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparable Immune Response of p53 Peptide Vaccine Delivered by Direct Subcutaneous Injections or by Intravenous Infusions of Peptide-Pulsed Dendritic Cells in Ovarian Cancer Patients T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42087472; 5524964 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Rahma, Osama AU - Achtar, Ed AU - Czystowska, Malgorzata AU - Szajnik, Marta AU - Wieckowski, Eva AU - Bernstein, Sarah AU - Herrin, Vincent AU - Steinberg, Seth AU - Merino, Maria AU - Gooding, William AU - Visus, Carmen AU - DeLeo, Albert AU - . Berzofsky, Jay AU - Whiteside, Theresa AU - Khleif, Samir Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Ovarian carcinoma KW - Immune response KW - Vaccines KW - Dendritic cells KW - P53 protein KW - Intravenous administration KW - Ovarian cancer KW - Peptides KW - Immunity KW - Defense mechanisms KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42087472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Comparable+Immune+Response+of+p53+Peptide+Vaccine+Delivered+by+Direct+Subcutaneous+Injections+or+by+Intravenous+Infusions+of+Peptide-Pulsed+Dendritic+Cells+in+Ovarian+Cancer+Patients&rft.au=Rahma%2C+Osama%3BAchtar%2C+Ed%3BCzystowska%2C+Malgorzata%3BSzajnik%2C+Marta%3BWieckowski%2C+Eva%3BBernstein%2C+Sarah%3BHerrin%2C+Vincent%3BSteinberg%2C+Seth%3BMerino%2C+Maria%3BGooding%2C+William%3BVisus%2C+Carmen%3BDeLeo%2C+Albert%3B.+Berzofsky%2C+Jay%3BWhiteside%2C+Theresa%3BKhleif%2C+Samir&rft.aulast=Rahma&rft.aufirst=Osama&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired Humoral Response to Influenza Vaccine and Prolonged B Memory Cells Depletion as Consequence of Rituximab Based Immunochemotherapy in Non Hodgkin Lymphoma Patients (Nhl Pts) T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42087439; 5524910 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Bedognetti, Davide AU - Zoppoli, Gabriele AU - Massucco, Carlotta AU - Zupo, Simonetta AU - Sertoli, Mario AU - Zanardi, Elisa AU - Messina, Marco AU - Siffredi, Guido AU - Bruzzone, Andrea AU - Balleari, Enrico AU - Ferrarini, Manlio AU - Nencioni, Alessio AU - Caltabiano, Graziano AU - Provinciali, Nicoletta AU - Racchi, Omar AU - Ferraris, Anna AU - Blandini, Pietro AU - Boccardo, Francesco AU - Sticchi, Laura AU - Icardi, Giancarlo AU - Marincola, Francesco AU - Bacilieri, Sabrina AU - Ansaldi, Filippo AU - De Maria, Andrea Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Lymphoma KW - Vaccines KW - Influenza KW - Hodgkin's disease KW - Memory cells KW - Lymphocytes B KW - Rituximab KW - Immune response (humoral) KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42087439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Impaired+Humoral+Response+to+Influenza+Vaccine+and+Prolonged+B+Memory+Cells+Depletion+as+Consequence+of+Rituximab+Based+Immunochemotherapy+in+Non+Hodgkin+Lymphoma+Patients+%28Nhl+Pts%29&rft.au=Bedognetti%2C+Davide%3BZoppoli%2C+Gabriele%3BMassucco%2C+Carlotta%3BZupo%2C+Simonetta%3BSertoli%2C+Mario%3BZanardi%2C+Elisa%3BMessina%2C+Marco%3BSiffredi%2C+Guido%3BBruzzone%2C+Andrea%3BBalleari%2C+Enrico%3BFerrarini%2C+Manlio%3BNencioni%2C+Alessio%3BCaltabiano%2C+Graziano%3BProvinciali%2C+Nicoletta%3BRacchi%2C+Omar%3BFerraris%2C+Anna%3BBlandini%2C+Pietro%3BBoccardo%2C+Francesco%3BSticchi%2C+Laura%3BIcardi%2C+Giancarlo%3BMarincola%2C+Francesco%3BBacilieri%2C+Sabrina%3BAnsaldi%2C+Filippo%3BDe+Maria%2C+Andrea&rft.aulast=Bedognetti&rft.aufirst=Davide&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross Talk between Constitutive Anti-Viral State in Cancer Cell Lines and the Host'S Immune Response During Oncolytic Therapy T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42087432; 5524951 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Worschech, Andrea AU - Ascierto, Maria AU - Chen, Nanhai AU - Yu, Yong AU - Zhang, Qian AU - DiPasquale, Giovanni AU - Pos, Zoltan AU - Wang, Ena AU - Szalay, Aladar AU - Marincola, Francesco Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Cancer KW - Immune response KW - Antiviral agents KW - Tumor cell lines KW - Oncolysis KW - Therapy KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42087432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Cross+Talk+between+Constitutive+Anti-Viral+State+in+Cancer+Cell+Lines+and+the+Host%27S+Immune+Response+During+Oncolytic+Therapy&rft.au=Worschech%2C+Andrea%3BAscierto%2C+Maria%3BChen%2C+Nanhai%3BYu%2C+Yong%3BZhang%2C+Qian%3BDiPasquale%2C+Giovanni%3BPos%2C+Zoltan%3BWang%2C+Ena%3BSzalay%2C+Aladar%3BMarincola%2C+Francesco&rft.aulast=Worschech&rft.aufirst=Andrea&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What are the Functional and Phenotypic Qualities of Therapeutically Successful Anti-Tumor T Cells? T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42087013; 5524770 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Restifo, Nicholas Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Lymphocytes T KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42087013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=What+are+the+Functional+and+Phenotypic+Qualities+of+Therapeutically+Successful+Anti-Tumor+T+Cells%3F&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Transfer Therapy for Patients with Metastatic Cancer T2 - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AN - 42086967; 5524769 JF - 24rd Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc 2009) AU - Rosenberg, Steven Y1 - 2009/10/23/ PY - 2009 DA - 2009 Oct 23 KW - Cancer KW - Metastases KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42086967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.atitle=Cell+Transfer+Therapy+for+Patients+with+Metastatic+Cancer&rft.au=Rosenberg%2C+Steven&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2009-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=24rd+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer+%28iSBTc+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/UserFiles/file/iSBTc-AM09-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. AN - 734085436; 19761212 AB - Schistosomiasis is a chronic parasitic disease affecting hundreds of millions of individuals worldwide. Current treatment depends on a single agent, praziquantel, raising concerns of emergence of resistant parasites. Here, we continue our explorations of an oxadiazole-2-oxide class of compounds we recently identified as inhibitors of thioredoxin glutathione reductase (TGR), a selenocysteine-containing flavoenzyme required by the parasite to maintain proper cellular redox balance. Through systematic evaluation of the core molecular structure of this chemotype, we define the essential pharmacophore, establish a link between the nitric oxide donation and TGR inhibition, determine the selectivity for this chemotype versus related reductase enzymes, and present evidence that these agents can be modified to possess appropriate drug metabolism and pharmacokinetic properties. The mechanistic link between exogenous NO donation and parasite injury is expanded and better defined. The results of these studies verify the utility of oxadiazole-2-oxides as novel inhibitors of TGR and as efficacious antischistosomal agents. JF - Journal of medicinal chemistry AU - Rai, Ganesha AU - Sayed, Ahmed A AU - Lea, Wendy A AU - Luecke, Hans F AU - Chakrapani, Harinath AU - Prast-Nielsen, Stefanie AU - Jadhav, Ajit AU - Leister, William AU - Shen, Min AU - Inglese, James AU - Austin, Christopher P AU - Keefer, Larry AU - Arnér, Elias S J AU - Simeonov, Anton AU - Maloney, David J AU - Williams, David L AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, Maryland 20892-3370, USA. Y1 - 2009/10/22/ PY - 2009 DA - 2009 Oct 22 SP - 6474 EP - 6483 VL - 52 IS - 20 KW - 1,2,5-oxadiazole 2-oxide KW - 0 KW - Enzyme Inhibitors KW - Multienzyme Complexes KW - Oxadiazoles KW - Schistosomicides KW - Nitric Oxide KW - 31C4KY9ESH KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - thioredoxin glutathione reductase KW - EC 1.6.4.- KW - Index Medicus KW - Drug Discovery KW - Animals KW - Solubility KW - Models, Molecular KW - NADH, NADPH Oxidoreductases -- chemistry KW - Humans KW - NADH, NADPH Oxidoreductases -- antagonists & inhibitors KW - Structure-Activity Relationship KW - Biological Availability KW - Multienzyme Complexes -- chemistry KW - Rats KW - Multienzyme Complexes -- antagonists & inhibitors KW - Substrate Specificity KW - Inhibitory Concentration 50 KW - Schistosoma -- drug effects KW - Protein Conformation KW - Schistosomiasis -- enzymology KW - Oxadiazoles -- therapeutic use KW - Enzyme Inhibitors -- therapeutic use KW - Enzyme Inhibitors -- chemistry KW - Schistosomicides -- chemistry KW - Oxadiazoles -- pharmacokinetics KW - Schistosomicides -- pharmacology KW - Schistosomicides -- therapeutic use KW - Oxadiazoles -- chemistry KW - Oxadiazoles -- pharmacology KW - Schistosomiasis -- drug therapy KW - Schistosomicides -- pharmacokinetics KW - Enzyme Inhibitors -- pharmacokinetics KW - Enzyme Inhibitors -- pharmacology KW - Nitric Oxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734085436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Structure+mechanism+insights+and+the+role+of+nitric+oxide+donation+guide+the+development+of+oxadiazole-2-oxides+as+therapeutic+agents+against+schistosomiasis.&rft.au=Rai%2C+Ganesha%3BSayed%2C+Ahmed+A%3BLea%2C+Wendy+A%3BLuecke%2C+Hans+F%3BChakrapani%2C+Harinath%3BPrast-Nielsen%2C+Stefanie%3BJadhav%2C+Ajit%3BLeister%2C+William%3BShen%2C+Min%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BKeefer%2C+Larry%3BArn%C3%A9r%2C+Elias+S+J%3BSimeonov%2C+Anton%3BMaloney%2C+David+J%3BWilliams%2C+David+L%3BThomas%2C+Craig+J&rft.aulast=Rai&rft.aufirst=Ganesha&rft.date=2009-10-22&rft.volume=52&rft.issue=20&rft.spage=6474&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm901021k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-24 N1 - Date created - 2009-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioorg Med Chem Lett. 2000 Sep 18;10(18):2097-100 [10999479] Science. 2008 Nov 28;322(5906):1392-5 [19039139] Int Immunopharmacol. 2001 Aug;1(8):1457-67 [11515811] Sci STKE. 2001 Jun 12;2001(86):pl1 [11752655] Int J Mol Med. 2002 Feb;9(2):131-4 [11786922] Int J Parasitol. 2002 Sep;32(10):1285-92 [12204228] Chem Biol. 2002 Dec;9(12):1329-35 [12498886] Acta Trop. 2003 May;86(2-3):125-39 [12745133] Biomed Pharmacother. 2003 May-Jun;57(3-4):145-55 [12818476] Chembiochem. 2003 Sep 5;4(9):899-903 [12964168] Trends Parasitol. 2004 Feb;20(2):92-7 [14747023] EMBO Rep. 2004 May;5(5):538-43 [15105824] Arch Biochem Biophys. 1967 Oct;122(1):164-73 [6076213] Z Parasitenkd. 1977 Jul 21;52(2):129-50 [410178] J Immunol. 1989 Dec 15;143(12):4208-12 [2592772] Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):444-8 [1346070] Neuron. 1992 Jun;8(6):1087-99 [1376999] Biochemistry. 1993 Jan 26;32(3):827-32 [8422387] J Med Chem. 1994 Dec 9;37(25):4412-6 [7996554] J Biol Chem. 1998 Apr 10;273(15):8581-91 [9535831] Nat Struct Biol. 1998 Apr;5(4):267-71 [9546215] Lancet. 1998 Apr 18;351(9110):1176-7 [9643692] Immunity. 1999 Jan;10(1):21-8 [10023767] Science. 2004 Nov 12;306(5699):1138-9 [15542455] Int J Parasitol. 2005 Jan;35(1):1-9 [15619510] Biochim Biophys Acta. 2005 Oct 30;1726(1):1-13 [15967579] Trends Parasitol. 2006 May;22(5):219-25 [16545612] Br J Pharmacol. 2006 Jun;148(4):517-26 [16702997] Lancet Infect Dis. 2006 Jul;6(7):411-25 [16790382] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Prog Nucleic Acid Res Mol Biol. 2006;81:97-142 [16891170] Curr Opin Infect Dis. 2006 Dec;19(6):577-82 [17075334] Nat Rev Drug Discov. 2006 Nov;5(11):941-55 [17080030] Antioxid Redox Signal. 2007 Jan;9(1):25-47 [17115886] Pharmacol Ther. 2007 Feb;113(2):442-58 [17222913] Bioorg Med Chem Lett. 2007 Feb 15;17(4):998-1002 [17157022] PLoS Med. 2007 Jun;4(6):e206 [17579510] J Infect Dis. 2007 Sep 15;196(6):954-62 [17703428] Exp Parasitol. 2007 Oct;117(2):165-70 [17511987] J Interferon Cytokine Res. 2007 Sep;27(9):781-7 [17892399] J Med Chem. 2007 Oct 4;50(20):5003-11 [17845020] PLoS Negl Trop Dis. 2008;2(1):e127 [18235848] Nat Rev Drug Discov. 2008 Feb;7(2):156-67 [18167491] Chronic Illn. 2008 Mar;4(1):65-79 [18322031] J Clin Invest. 2008 Apr;118(4):1311-21 [18382743] PLoS One. 2008;3(4):e1846 [18382651] Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5022-7 [18367671] J Org Chem. 2009 Feb 20;74(4):1450-3 [19146387] PLoS Negl Trop Dis. 2009;3(6):e464 [19554083] Mol Biol Evol. 2009 Sep;26(9):2031-40 [19487332] Nat Med. 2008 Apr;14(4):407-12 [18345010] Proteins. 2008 Aug 15;72(3):936-45 [18300227] Assay Drug Dev Technol. 2008 Aug;6(4):551-5 [18665782] J Am Chem Soc. 2008 Sep 24;130(38):12570-1 [18729360] Expert Opin Investig Drugs. 2008 Oct;17(10):1427-33 [18808305] Curr Opin Infect Dis. 2008 Dec;21(6):659-67 [18978535] Circulation. 2000 Oct 31;102(18):2276-81 [11056105] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm901021k ER - TY - CPAPER T1 - Effective Transvascular Delivery of Nanoparticle-based Therapeutics into the Central Nervous System T2 - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AN - 42578986; 5483173 JF - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AU - Sarin, Hemant Y1 - 2009/10/22/ PY - 2009 DA - 2009 Oct 22 KW - Central nervous system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42578986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.atitle=Effective+Transvascular+Delivery+of+Nanoparticle-based+Therapeutics+into+the+Central+Nervous+System&rft.au=Sarin%2C+Hemant&rft.aulast=Sarin&rft.aufirst=Hemant&rft.date=2009-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iddst.com/iddst2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting Mesothelin in Ovarian Cancer and Mesothelioma T2 - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AN - 42577431; 5483262 JF - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AU - Ho, Mitchell Y1 - 2009/10/22/ PY - 2009 DA - 2009 Oct 22 KW - Ovarian carcinoma KW - Mesothelioma KW - Ovarian cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42577431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.atitle=Targeting+Mesothelin+in+Ovarian+Cancer+and+Mesothelioma&rft.au=Ho%2C+Mitchell&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2009-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iddst.com/iddst2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antimicrobial Resistance and Antibacterial Drug Discovery T2 - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AN - 42576150; 5483219 JF - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AU - Xu, Zuoyu Y1 - 2009/10/22/ PY - 2009 DA - 2009 Oct 22 KW - Drug discovery KW - Antimicrobial agents KW - Antimicrobial resistance KW - Antibiotics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42576150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.atitle=Antimicrobial+Resistance+and+Antibacterial+Drug+Discovery&rft.au=Xu%2C+Zuoyu&rft.aulast=Xu&rft.aufirst=Zuoyu&rft.date=2009-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iddst.com/iddst2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Antibodies and Beyond: Current State and Future Trends T2 - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AN - 42574318; 5483260 JF - BIT's 7th Annual Congress of International Drug Discovery Science and Technology (IDDST 2009) AU - Dimitrov, Dimiter Y1 - 2009/10/22/ PY - 2009 DA - 2009 Oct 22 KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42574318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.atitle=Therapeutic+Antibodies+and+Beyond%3A+Current+State+and+Future+Trends&rft.au=Dimitrov%2C+Dimiter&rft.aulast=Dimitrov&rft.aufirst=Dimiter&rft.date=2009-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+7th+Annual+Congress+of+International+Drug+Discovery+Science+and+Technology+%28IDDST+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iddst.com/iddst2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A dosimetric comparison of four treatment planning methods for high grade glioma. AN - 734130541; 19845946 AB - High grade gliomas (HGG) are typically treated with a combination of surgery, radiotherapy and chemotherapy. Three dimensional (3D) conformal radiotherapy treatment planning is still the main stay of treatment for these patients. New treatment planning methods suggest better dose distributions and organ sparing but their clinical benefit is unclear. The purpose of the current study was to compare normal tissue sparing and tumor coverage using four different radiotherapy planning methods in patients with high grade glioma. Three dimensional conformal (3D), sequential boost IMRT, integrated boost (IB) IMRT and Tomotherapy (TOMO) treatment plans were generated for 20 high grade glioma patients. T1 and T2 MRI abnormalities were used to define GTV and CTV with 2 and 2.5 cm margins to define PTV1 and PTV2 respectively. The mean dose to PTV2 but not to PTV1 was less then 95% of the prescribed dose with IB and IMRT plans. The mean doses to the optic chiasm and the ipsilateral globe were highest with 3D plans and least with IB plans. The mean dose to the contralateral globe was highest with TOMO plans. The mean of the integral dose (ID) to the brain was least with the IB plan and was lower with IMRT compared to 3D plans. The TOMO plans had the least mean D10 to the normal brain but higher mean D50 and D90 compared to IB and IMRT plans. The mean D10 and D50 but not D90 were significantly lower with the IMRT plans compared to the 3D plans. No single treatment planning method was found to be superior to all others and a personalized approach is advised for planning and treating high-grade glioma patients with radiotherapy. Integral dose did not reflect accurately the dose volume histogram (DVH) of the normal brain and may not be a good indicator of delayed radiation toxicity. JF - Radiation oncology (London, England) AU - Zach, Leor AU - Stall, Bronwyn AU - Ning, Holly AU - Ondos, John AU - Arora, Barbara AU - Uma, Shankavaram AU - Miller, Robert W AU - Citrin, Deborah AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Building 10, CRC, Bethesda, MD 20892, USA. zachl@mail.nih.gov Y1 - 2009/10/21/ PY - 2009 DA - 2009 Oct 21 SP - 45 VL - 4 KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Radiotherapy, Conformal -- methods KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Brain Neoplasms -- radiotherapy KW - Glioma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+oncology+%28London%2C+England%29&rft.atitle=A+dosimetric+comparison+of+four+treatment+planning+methods+for+high+grade+glioma.&rft.au=Zach%2C+Leor%3BStall%2C+Bronwyn%3BNing%2C+Holly%3BOndos%2C+John%3BArora%2C+Barbara%3BUma%2C+Shankavaram%3BMiller%2C+Robert+W%3BCitrin%2C+Deborah%3BCamphausen%2C+Kevin&rft.aulast=Zach&rft.aufirst=Leor&rft.date=2009-10-21&rft.volume=4&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Radiation+oncology+%28London%2C+England%29&rft.issn=1748-717X&rft_id=info:doi/10.1186%2F1748-717X-4-45 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2001 Dec 20;96(6):341-9 [11745504] Med Dosim. 2008 Autumn;33(3):215-21 [18674686] Cancer Res. 2003 Jul 15;63(14):4021-7 [12874001] Jpn J Clin Oncol. 2003 Jun;33(6):271-7 [12913080] Int J Radiat Oncol Biol Phys. 2004 Nov 1;60(3):853-60 [15465203] Int J Radiat Oncol Biol Phys. 1997 Dec 1;39(5):967-75 [9392533] Cell. 1999 Jun 11;97(6):703-16 [10380923] Int J Clin Oncol. 2004 Dec;9(6):491-7 [15616880] N Engl J Med. 2005 Aug 25;353(8):811-22 [16120861] Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):962-7 [16458781] Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1317-24 [16580493] Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1422-8 [16750317] Int J Radiat Oncol Biol Phys. 2007 Mar 15;67(4):1135-44 [17208388] Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):324-33 [17398036] Exp Neurol. 2007 Jun;205(2):313-24 [17459377] Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):978-85 [17467925] Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):589-97 [17869672] Neuro Oncol. 2007 Oct;9(4):424-9 [17622647] Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):9-14 [19100920] J Clin Oncol. 2002 Mar 15;20(6):1635-42 [11896114] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1748-717X-4-45 ER - TY - JOUR T1 - Characteristics of children enrolled in treatment trials for NF1-related plexiform neurofibromas. AN - 66636033; 19841379 AB - To describe the characteristics of children enrolled in treatment trials for neurofibromatosis type 1 (NF1)-related plexiform neurofibroma (PN), PN tumor burden, PN-related complications, and treatment outcomes and to highlight the differences between characteristics of children with NF1 vs children with cancers entered on early phase drug trials. Pre-enrollment characteristics and complications of PN were retrospectively analyzed in a cohort of 59 children with NF1-related PN treated on 1 of 7 clinical trials at the NIH between 1996 and 2007. Outcome was analyzed in a subset of 19 patients enrolled in phase I trials. Comparisons to children with cancer were made from a similar analysis performed recently. The median age at enrollment was 8 years. The median PN volume was 555 mL. Most patients had no prior chemotherapy or radiation, but nearly half had previous surgery for PN. PN-associated complications and NF1 manifestations were common, including pain (53%), other tumors (18%), and hypertension (8%). Investigational drug therapy was well tolerated. A median of 10 treatment cycles was administered. Patients with NF1-related PN were younger, had better performance score, had less prior therapy, and remained on study longer than cancer patients. Children with NF1-related plexiform neurofibroma (PN) enrolled in clinical trials had large tumors with substantial morbidity. Clinical trials in these children provide information about drug tolerance, cumulative toxicity, and pharmacokinetics in a younger population than early phase pediatric cancer trials. This report may aid in the evaluation of the applicability of traditional pediatric cancer trial designs and endpoints for NF1-related PN. JF - Neurology AU - Kim, A AU - Gillespie, A AU - Dombi, E AU - Goodwin, A AU - Goodspeed, W AU - Fox, E AU - Balis, F M AU - Widemann, B C AD - National Cancer Institute, Pediatric Oncology Branch, NIH, Bethesda, MD 20892, USA. kimaer@mail.nih.gov Y1 - 2009/10/20/ PY - 2009 DA - 2009 Oct 20 SP - 1273 EP - 1279 VL - 73 IS - 16 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Head and Neck Neoplasms -- complications KW - Humans KW - Retrospective Studies KW - Head and Neck Neoplasms -- pathology KW - Abdominal Neoplasms -- drug therapy KW - Child KW - Head and Neck Neoplasms -- drug therapy KW - Child, Preschool KW - Infant KW - Pain -- etiology KW - Abdominal Neoplasms -- pathology KW - Thoracic Neoplasms -- pathology KW - Thoracic Neoplasms -- drug therapy KW - Cohort Studies KW - Treatment Outcome KW - Hypertension -- etiology KW - Thoracic Neoplasms -- complications KW - Abdominal Neoplasms -- complications KW - Adolescent KW - Male KW - Female KW - Neurofibromatosis 1 -- drug therapy KW - Neurofibroma, Plexiform -- complications KW - Clinical Trials, Phase II as Topic KW - Neurofibroma, Plexiform -- drug therapy KW - Neurofibroma, Plexiform -- pathology KW - Clinical Trials, Phase I as Topic KW - Antineoplastic Agents -- pharmacokinetics KW - Neurofibromatosis 1 -- complications KW - Antineoplastic Agents -- therapeutic use KW - Neurofibromatosis 1 -- pathology KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66636033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Characteristics+of+children+enrolled+in+treatment+trials+for+NF1-related+plexiform+neurofibromas.&rft.au=Kim%2C+A%3BGillespie%2C+A%3BDombi%2C+E%3BGoodwin%2C+A%3BGoodspeed%2C+W%3BFox%2C+E%3BBalis%2C+F+M%3BWidemann%2C+B+C&rft.aulast=Kim&rft.aufirst=A&rft.date=2009-10-20&rft.volume=73&rft.issue=16&rft.spage=1273&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2FWNL.0b013e3181bd1326 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-10 N1 - Date created - 2009-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Radiology. 2009 Mar;250(3):665-73 [19244040] Trends Cardiovasc Med. 2000 Jul;10(5):223-8 [11282299] Am J Hum Genet. 2001 May;68(5):1110-8 [11283797] Neurology. 2002 May 28;58(10):1461-70 [12041525] Neurology. 2003 Jan 14;60(1):130-2 [12525736] AJR Am J Roentgenol. 2003 Feb;180(2):419-23 [12540445] Comput Med Imaging Graph. 2004 Jul;28(5):257-65 [15249071] Cancer. 1981 Jan 1;47(1):207-14 [7459811] J Pediatr. 1997 Nov;131(5):678-82 [9403645] Nat Med. 1999 Jun;5(6):623-8 [10371499] Am J Med Genet. 1999 Mar 26;89(1):31-7 [10469434] Neurology. 2005 Feb 8;64(3):553-5 [15699396] J Clin Oncol. 2005 Nov 20;23(33):8431-41 [16293874] J Clin Oncol. 2006 Jan 20;24(3):507-16 [16421428] J Clin Oncol. 2006 Mar 20;24(9):1329-31 [16446321] Neurology. 2007 Feb 27;68(9):643-7 [17215493] Pediatr Neurol. 2007 May;36(5):293-300 [17509460] J Clin Oncol. 2008 Jan 20;26(3):399-405 [18202416] Oncologist. 2008 Jun;13(6):679-89 [18586923] Pediatr Nephrol. 2000 Aug;14(8-9):806-10 [10955932] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1212/WNL.0b013e3181bd1326 ER - TY - CPAPER T1 - Immunologic Determinants of Mycobacterial Associated Immune Reconstitution Inflammatory Syndrome (IRIS) in a Murine Experimental Model T2 - Overcoming the Crisis of TB and AIDS (T2) AN - 42460787; 5425833 JF - Overcoming the Crisis of TB and AIDS (T2) AU - Sher, Alan Y1 - 2009/10/20/ PY - 2009 DA - 2009 Oct 20 KW - Animal models KW - Inflammation KW - Immune reconstitution KW - Symptoms KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42460787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Overcoming+the+Crisis+of+TB+and+AIDS+%28T2%29&rft.atitle=Immunologic+Determinants+of+Mycobacterial+Associated+Immune+Reconstitution+Inflammatory+Syndrome+%28IRIS%29+in+a+Murine+Experimental+Model&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2009-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Overcoming+the+Crisis+of+TB+and+AIDS+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 22&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Implementing personalized medicine T2 - 59th Annual Meeting of The American Society of Human Genetics AN - 42057395; 5509381 JF - 59th Annual Meeting of The American Society of Human Genetics AU - Guttmacher, A Y1 - 2009/10/20/ PY - 2009 DA - 2009 Oct 20 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42057395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+The+American+Society+of+Human+Genetics&rft.atitle=Implementing+personalized+medicine&rft.au=Guttmacher%2C+A&rft.aulast=Guttmacher&rft.aufirst=A&rft.date=2009-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+The+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://ashg.org/2009meeting/pdf/ashg09_programguide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells. AN - 733698551; 19838300 AB - Ribosomal RNA (rRNA) is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA) upstream from the 45S rRNA transcription start site has recently been implicated in control of rRNA transcription in mouse fibroblasts. We investigated whether a similar nc-rRNA might be expressed in human cancer epithelial cells, and related to any genomic characteristics. Using quantitative rRNA measurement, we demonstrated that a nc-rRNA is transcribed in human lung epithelial and lung cancer cells, starting from approximately -1000 nucleotides upstream of the rRNA transcription start site (+1) and extending at least to +203. This nc-rRNA was significantly more abundant in the majority of lung cancer cell lines, relative to a nontransformed lung epithelial cell line. Its abundance correlated negatively with total 45S rRNA in 12 of 13 cell lines (P = 0.014). During sequence analysis from -388 to +306, we observed diverse, frequent intercopy single nucleotide polymorphisms (SNPs) in rRNA, with a frequency greater than predicted by chance at 12 sites. A SNP at +139 (U/C) in the 5' leader sequence varied among the cell lines and correlated negatively with level of the nc-rRNA (P = 0.014). Modelling of the secondary structure of the rRNA 5'-leader sequence indicated a small increase in structural stability due to the +139 U/C SNP and a minor shift in local configuration occurrences. The results demonstrate occurrence of a sense nc-rRNA in human lung epithelial and cancer cells, and imply a role in regulation of the rRNA gene, which may be affected by a +139 SNP in the 5' leader sequence of the primary rRNA transcript. JF - PloS one AU - Shiao, Yih-Horng AU - Lupascu, Sorin T AU - Gu, Yuhan D AU - Kasprzak, Wojciech AU - Hwang, Christopher J AU - Fields, Janet R AU - Leighty, Robert M AU - Quiñones, Octavio AU - Shapiro, Bruce A AU - Alvord, W Gregory AU - Anderson, Lucy M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland, USA. shiaoy@mail.nih.gov Y1 - 2009/10/19/ PY - 2009 DA - 2009 Oct 19 SP - 1 VL - 4 IS - 10 KW - RNA, Ribosomal KW - 0 KW - Index Medicus KW - Animals KW - Models, Genetic KW - Humans KW - Transcription, Genetic KW - Mice KW - Cell Line, Tumor KW - Lung -- metabolism KW - Nucleic Acid Conformation KW - Fibroblasts -- metabolism KW - Cell Line KW - Genomics KW - Cloning, Molecular KW - Polymorphism, Single Nucleotide KW - RNA, Ribosomal -- genetics KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733698551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=An+intergenic+non-coding+rRNA+correlated+with+expression+of+the+rRNA+and+frequency+of+an+rRNA+single+nucleotide+polymorphism+in+lung+cancer+cells.&rft.au=Shiao%2C+Yih-Horng%3BLupascu%2C+Sorin+T%3BGu%2C+Yuhan+D%3BKasprzak%2C+Wojciech%3BHwang%2C+Christopher+J%3BFields%2C+Janet+R%3BLeighty%2C+Robert+M%3BQui%C3%B1ones%2C+Octavio%3BShapiro%2C+Bruce+A%3BAlvord%2C+W+Gregory%3BAnderson%2C+Lucy+M&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2009-10-19&rft.volume=4&rft.issue=10&rft.spage=e7505&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007505 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-12 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1997 Nov 1;57(21):4898-904 [9354455] RNA. 2009 Jun;15(6):1177-87 [19383766] Am J Hum Genet. 1999 Jan;64(1):24-30 [9915939] Bioinformatics. 1999 Jan;15(1):16-31 [10068689] J Mol Biol. 1999 May 21;288(5):911-40 [10329189] J Biomol Struct Dyn. 2006 Feb;23(4):417-28 [16363877] Nucleic Acids Res. 2005;33(22):7151-63 [16371347] Exp Cell Res. 2006 Apr 15;312(7):1185-93 [16510138] Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29 [16651366] Mol Cell. 2006 May 5;22(3):351-61 [16678107] RNA. 2006 Aug;12(8):1521-33 [16790843] J Mol Graph Model. 2006 Dec;25(4):514-31 [16725358] Oncogene. 2006 Dec 7;25(58):7577-86 [16924243] Cell Mol Life Sci. 2007 Jan;64(1):29-49 [17171232] Nature. 2007 Feb 8;445(7128):666-70 [17237763] Mol Cell Biol. 2007 Jul;27(13):4938-52 [17452452] PLoS One. 2007;2(9):e902 [17878937] Biol Cell. 2008 Feb;100(2):83-95 [18199047] PLoS One. 2008;3(3):e1843 [18365001] PLoS One. 2008;3(5):e2085 [18461137] Biol Chem. 2008 Apr;389(4):323-31 [18225988] FASEB J. 1999 Nov;13(14):1911-22 [10544174] Clin Genet. 2000 Jun;57(6):409-14 [10905659] Bioinformatics. 2001 Feb;17(2):137-48 [11238069] J Mol Biol. 2001 Sep 7;312(1):27-44 [11545583] Mol Cell Biol. 2002 Jan;22(2):657-68 [11756560] Hear Res. 2002 Jul;169(1-2):47-55 [12121739] Nat Rev Cancer. 2003 Mar;3(3):179-92 [12612653] Nucleic Acids Res. 2003 Jul 1;31(13):3406-15 [12824337] J Biol Chem. 2004 Feb 20;279(8):6783-93 [14610093] Cancer Res. 2004 Aug 15;64(16):5651-8 [15313903] Hum Genet. 1985;69(3):212-7 [2579890] J Cell Sci. 1985 Mar;74:21-35 [4030908] Mol Cell Biol. 1987 Aug;7(8):2891-8 [3670298] Biochem J. 1987 Sep 1;246(2):519-27 [3689320] Science. 1988 Jan 1;239(4835):64-8 [3336775] Proc Natl Acad Sci U S A. 1988 Feb;85(3):669-73 [3422449] Science. 1988 Sep 2;241(4870):1192-7 [3413483] FEBS Lett. 1989 Apr 24;247(2):298-302 [2565822] FEBS Lett. 1989 Jun 5;249(2):279-84 [2737289] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6523-7 [2771939] Eur J Biochem. 1991 Feb 14;195(3):601-9 [1999184] Nucleic Acids Res. 1991 Mar 11;19(5):1015-9 [2020541] Nucleic Acids Res. 1992 Apr 11;20(7):1483-6 [1579439] Nucleic Acids Res. 1993 Mar 25;21(6):1449-55 [8464736] Antimicrob Agents Chemother. 1994 Nov;38(11):2517-20 [7872740] Comput Appl Biosci. 1996 Jun;12(3):171-80 [8872384] Biochimie. 1996;78(6):530-8 [8915542] Nucleic Acids Res. 1996 Dec 1;24(23):4817-24 [8972871] J Mol Graph. 1996 Aug;14(4):194-205, 222-4 [9076633] Am J Pathol. 2008 Aug;173(2):301-10 [18583314] EMBO Rep. 2008 Aug;9(8):774-80 [18600236] BMC Mol Biol. 2008;9:69 [18671841] Annu Rev Cell Dev Biol. 2008;24:131-57 [18616426] Nature. 2008 Nov 6;456(7218):130-4 [18820678] Micron. 2009 Jul-Aug;40(5-6):511-8 [19339189] Front Biosci. 1998 Sep 1;3:D985-8 [9727087] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0007505 ER - TY - JOUR T1 - Preparation, characterization, and immunogenicity in mice of a recombinant influenza H5 hemagglutinin vaccine against the avian H5N1 A/Vietnam/1203/2004 influenza virus AN - 21231808; 11790810 AB - Production of influenza vaccines requires a minimum of 6 months after the circulating strain is isolated and the use of infectious viruses. The hemagglutinin (protective antigen) of circulating influenza viruses mutates rapidly requiring reformulation of the vaccines. Our goal is to eliminate the risk of working with infectious virus and reduce significantly the production time. A cDNA fragment encoding the influenza virus A/Vietnam/1203/2004 (H5N1) HA gene was prepared using RT-PCR with viral RNA as a template. Recombinant HA (rHA) protein was produced in Escherichia coli and purified from isolated inclusion bodies by urea solubilization and Ni super(+)-ion column chromatography. Vaccine candidates were prepared by treating the rHA with formalin, adsorption onto alum or with both. Mice were injected subcutaneously with candidate vaccines two or three times 2 weeks apart. Sera were collected 1 week after the last injection and antibody measured by ELISA and hemagglutination inhibition (HI). The highest antibody response (GM 449 EU) was elicited by three injections of 15 kg alum-adsorbed rHA. Dosages of 5 kg of rHA formulated with formalin and alum, and 5 kg alum-adsorbed rHA elicited IgG anti-HA of GM 212 and 177 EU, respectively. HI titers, >=40 were obtained in >=80% of mice with three doses of all formulations. We developed a method to produce rHA in a time-frame suitable for annual and pandemic influenza vaccination. Using this method, rHA vaccine can be produced in 3-4 weeks and when formulated with alum, induces HA antibody levels in young outbred mice consistent with the FDA guidelines for vaccines against epidemic and pandemic influenza. JF - Vaccine AU - Biesova, Zuzana AU - Miller, Mark A AU - Schneerson, Rachel AU - Shiloach, Joseph AU - Green, Kim Y AU - Robbins, John B AU - Keith, Jerry M AD - Program in Developmental and Molecular Immunity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States, keithjer@mail.nih.gov Y1 - 2009/10/19/ PY - 2009 DA - 2009 Oct 19 SP - 6234 EP - 6238 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 27 IS - 44 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Adsorption KW - Aluminum sulfate KW - Antibody response KW - Column chromatography KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Formaldehyde KW - Hemagglutination inhibition KW - Hemagglutinins KW - Immunogenicity KW - Immunoglobulin G KW - Inclusion bodies KW - Influenza KW - Polymerase chain reaction KW - RNA KW - Solubilization KW - Urea KW - Vaccines KW - pandemics KW - protective antigen KW - Influenza A virus KW - Escherichia coli KW - Influenza virus KW - V 22350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21231808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Preparation%2C+characterization%2C+and+immunogenicity+in+mice+of+a+recombinant+influenza+H5+hemagglutinin+vaccine+against+the+avian+H5N1+A%2FVietnam%2F1203%2F2004+influenza+virus&rft.au=Biesova%2C+Zuzana%3BMiller%2C+Mark+A%3BSchneerson%2C+Rachel%3BShiloach%2C+Joseph%3BGreen%2C+Kim+Y%3BRobbins%2C+John+B%3BKeith%2C+Jerry+M&rft.aulast=Biesova&rft.aufirst=Zuzana&rft.date=2009-10-19&rft.volume=27&rft.issue=44&rft.spage=6234&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.07.107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Epidemics; Hemagglutination inhibition; Hemagglutinins; protective antigen; Formaldehyde; Column chromatography; Urea; Antibody response; Influenza; pandemics; Aluminum sulfate; RNA; Immunogenicity; Solubilization; Adsorption; Immunoglobulin G; Inclusion bodies; Polymerase chain reaction; Vaccines; Influenza virus; Influenza A virus; Escherichia coli DO - http://dx.doi.org/10.1016/j.vaccine.2009.07.107 ER - TY - CPAPER T1 - A Dissociation of Laterality for Language Production and Comprehension in a Subcortical Aphasic Patient, Assessed with Meg and Fmri T2 - 47th Annual Meeting of the Academy of Aphasia AN - 42438654; 5414077 JF - 47th Annual Meeting of the Academy of Aphasia AU - Meltzer, J AU - Braun, A Y1 - 2009/10/18/ PY - 2009 DA - 2009 Oct 18 KW - Language KW - Functional magnetic resonance imaging KW - Magnetoencephalography KW - Dissociation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42438654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Academy+of+Aphasia&rft.atitle=A+Dissociation+of+Laterality+for+Language+Production+and+Comprehension+in+a+Subcortical+Aphasic+Patient%2C+Assessed+with+Meg+and+Fmri&rft.au=Meltzer%2C+J%3BBraun%2C+A&rft.aulast=Meltzer&rft.aufirst=J&rft.date=2009-10-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Academy+of+Aphasia&rft.issn=&rft_id=info:doi/ L2 - http://academy.angularis.org/Annual_Meeting/2009/CoverSheet/Site/Progr am/overview.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nigella sativa L oil ameliorates methotrexate-induced intestinal toxicity in rats T2 - 2009 Annual Meeting of the American College of Clinical Pharmacy AN - 42097643; 5529868 JF - 2009 Annual Meeting of the American College of Clinical Pharmacy AU - Labib, Rania AU - Hafez, Hafez AU - Badary, Osama Y1 - 2009/10/18/ PY - 2009 DA - 2009 Oct 18 KW - Toxicity KW - Oil KW - Rats KW - Intestine KW - Nigella sativa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42097643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=Nigella+sativa+L+oil+ameliorates+methotrexate-induced+intestinal+toxicity+in+rats&rft.au=Labib%2C+Rania%3BHafez%2C+Hafez%3BBadary%2C+Osama&rft.aulast=Labib&rft.aufirst=Rania&rft.date=2009-10-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/docs/meetings/am09/MondayPosters.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute T Cell Leukemia: An in vivo Struggle Between HTLV-1-Production and Type 1 Interferon Production T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42465869; 5426288 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Ruscetti, Francis Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Leukemia KW - Interferon KW - Lymphocytes T KW - Human T-lymphotropic virus 1 KW - Human T-lymphotropic virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42465869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Acute+T+Cell+Leukemia%3A+An+in+vivo+Struggle+Between+HTLV-1-Production+and+Type+1+Interferon+Production&rft.au=Ruscetti%2C+Francis&rft.aulast=Ruscetti&rft.aufirst=Francis&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Gene Expression Patterns in IFN-GAMMA 3'Untranslated Region Au-Rich Element-Deleted Mice T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42464713; 5426293 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Hodge, Deborah Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mice KW - Gene expression KW - G-Interferon KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42464713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Novel+Gene+Expression+Patterns+in+IFN-GAMMA+3%27Untranslated+Region+Au-Rich+Element-Deleted+Mice&rft.au=Hodge%2C+Deborah&rft.aulast=Hodge&rft.aufirst=Deborah&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin A Derived Retinoic Acid Signaling Mediates Intestinal Immune Homeostasis and Immunity T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42462980; 5426342 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Hall, Jason Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Vitamin A KW - Signal transduction KW - Intestine KW - Retinoic acid KW - Immunity KW - Homeostasis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42462980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Vitamin+A+Derived+Retinoic+Acid+Signaling+Mediates+Intestinal+Immune+Homeostasis+and+Immunity&rft.au=Hall%2C+Jason&rft.aulast=Hall&rft.aufirst=Jason&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Type I Interferon Transcription by IRF3/7 Sumoylation T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42462195; 5426257 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Ozato, Keiko Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - SUMO protein KW - Transcription KW - Interferon regulatory factor 3 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42462195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Inhibition+of+Type+I+Interferon+Transcription+by+IRF3%2F7+Sumoylation&rft.au=Ozato%2C+Keiko&rft.aulast=Ozato&rft.aufirst=Keiko&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting "Alternative Macrophage Activation": The Role of L-Arginine Metabolism in Chronic Inflammation and Fibrosis T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42461867; 5426314 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Wynn, Tom Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Metabolism KW - Fibrosis KW - Inflammation KW - Macrophages KW - Arginine KW - Cell activation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42461867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Dissecting+%22Alternative+Macrophage+Activation%22%3A+The+Role+of+L-Arginine+Metabolism+in+Chronic+Inflammation+and+Fibrosis&rft.au=Wynn%2C+Tom&rft.aulast=Wynn&rft.aufirst=Tom&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Macrophage's Dual Role in Health and Disease T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42461784; 5426315 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Gordon, Siamon Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42461784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=The+Macrophage%27s+Dual+Role+in+Health+and+Disease&rft.au=Gordon%2C+Siamon&rft.aulast=Gordon&rft.aufirst=Siamon&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Pathogenesis of West Nile Virus Encephalitis T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42461756; 5426313 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Murphy, Phil Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Encephalitis KW - West Nile virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42461756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Molecular+Pathogenesis+of+West+Nile+Virus+Encephalitis&rft.au=Murphy%2C+Phil&rft.aulast=Murphy&rft.aufirst=Phil&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Critical Function of TGF-beta in the Generation of Adaptive and Natural CD4+Foxp3+ Regulatory T Cells T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42459948; 5426226 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - Chen, Wanjun Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Lymphocytes T KW - Immunoregulation KW - Foxp3 protein KW - CD4 antigen KW - Transforming growth factor-b KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=A+Critical+Function+of+TGF-beta+in+the+Generation+of+Adaptive+and+Natural+CD4%2BFoxp3%2B+Regulatory+T+Cells&rft.au=Chen%2C+Wanjun&rft.aulast=Chen&rft.aufirst=Wanjun&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptional and Epigenetic Regulation of Helper T Cell Differentiation T2 - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AN - 42459818; 5426241 JF - Joint Annual Meeting of the International Cytokine Society, the International Society for Interferon and Cytokine Research and the Society of Leukocyte Biology AU - O'Shea, John Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cell differentiation KW - Differentiation KW - Transcription KW - Lymphocytes T KW - Gene regulation KW - Epigenetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.atitle=Transcriptional+and+Epigenetic+Regulation+of+Helper+T+Cell+Differentiation&rft.au=O%27Shea%2C+John&rft.aulast=O%27Shea&rft.aufirst=John&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+International+Cytokine+Society%2C+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+Society+of+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.trisociety2009.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cholinergic mediation of visual recognition memory in monkeys: Differential effects of muscarinic ml and m2 receptor subtypes T2 - 39th Annual meeting of the Society for Neuroscience AN - 42225500; 5589931 JF - 39th Annual meeting of the Society for Neuroscience AU - Turchi, J AU - Wu, W. AU - Saunders, R AU - Mishkin, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Memory KW - Visual perception KW - Acetylcholine receptors (muscarinic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Cholinergic+mediation+of+visual+recognition+memory+in+monkeys%3A+Differential+effects+of+muscarinic+ml+and+m2+receptor+subtypes&rft.au=Turchi%2C+J%3BWu%2C+W.%3BSaunders%2C+R%3BMishkin%2C+M&rft.aulast=Turchi&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The rostral part of the external pallidum and the ventral pallidum convey reward-associated visuomotor information T2 - 39th Annual meeting of the Society for Neuroscience AN - 42221556; 5588195 JF - 39th Annual meeting of the Society for Neuroscience AU - Tachibana, Y AU - Hikosaka, O Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Globus pallidus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42221556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+rostral+part+of+the+external+pallidum+and+the+ventral+pallidum+convey+reward-associated+visuomotor+information&rft.au=Tachibana%2C+Y%3BHikosaka%2C+O&rft.aulast=Tachibana&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - lmaging of F-18 labeled adenosine A2A receptor antagonist in the rat striatum with positron emission tomography T2 - 39th Annual meeting of the Society for Neuroscience AN - 42220597; 5587736 JF - 39th Annual meeting of the Society for Neuroscience AU - Bhattacharjee, A AU - Lang, L AU - Jacobson, O AU - Shinkre, B AU - Shi, Y AU - Ma, Y. AU - Gao, Z AU - Trenkle, W AU - Jacobson, K AU - Kiesewetter, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Emissions KW - Adenosine A2A receptors KW - Neostriatum KW - Positron emission tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42220597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=lmaging+of+F-18+labeled+adenosine+A2A+receptor+antagonist+in+the+rat+striatum+with+positron+emission+tomography&rft.au=Bhattacharjee%2C+A%3BLang%2C+L%3BJacobson%2C+O%3BShinkre%2C+B%3BShi%2C+Y%3BMa%2C+Y.%3BGao%2C+Z%3BTrenkle%2C+W%3BJacobson%2C+K%3BKiesewetter%2C+D&rft.aulast=Bhattacharjee&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural and molecular basis of impaired fear extinction in the inbred mouse strain 129S1/SvlmJ T2 - 39th Annual meeting of the Society for Neuroscience AN - 42220184; 5589359 JF - 39th Annual meeting of the Society for Neuroscience AU - Camp, M AU - Graybeal, C AU - Ihne, J AU - Whittle, N AU - Gaburro, S AU - Singewald, N AU - Holmes, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Extinction KW - Inbreeding KW - Fear conditioning KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42220184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+and+molecular+basis+of+impaired+fear+extinction+in+the+inbred+mouse+strain+129S1%2FSvlmJ&rft.au=Camp%2C+M%3BGraybeal%2C+C%3BIhne%2C+J%3BWhittle%2C+N%3BGaburro%2C+S%3BSingewald%2C+N%3BHolmes%2C+A&rft.aulast=Camp&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A comparison of reward-related neuronal responses in the monkey limbic system T2 - 39th Annual meeting of the Society for Neuroscience AN - 42219763; 5587833 JF - 39th Annual meeting of the Society for Neuroscience AU - Simmons, J M AU - Ravel, S AU - Bouret, S AU - Sugase-Miyamoto, Y AU - Shidara, M AU - Richmond, B Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Limbic system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=A+comparison+of+reward-related+neuronal+responses+in+the+monkey+limbic+system&rft.au=Simmons%2C+J+M%3BRavel%2C+S%3BBouret%2C+S%3BSugase-Miyamoto%2C+Y%3BShidara%2C+M%3BRichmond%2C+B&rft.aulast=Simmons&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of prior probability on behavior and neural activity in a perceptual decision-making task T2 - 39th Annual meeting of the Society for Neuroscience AN - 42219727; 5588913 JF - 39th Annual meeting of the Society for Neuroscience AU - Bell, A H AU - Malecek, N AU - Hadj-Bouziane, F AU - Tootell, R B H AU - Ungerleider, L G Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Influence+of+prior+probability+on+behavior+and+neural+activity+in+a+perceptual+decision-making+task&rft.au=Bell%2C+A+H%3BMalecek%2C+N%3BHadj-Bouziane%2C+F%3BTootell%2C+R+B+H%3BUngerleider%2C+L+G&rft.aulast=Bell&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A comparative behavioral study of the beneficial effects of mood stabilizing drugs lithium and valproate in transgenic mouse models of Huntington's disease T2 - 39th Annual meeting of the Society for Neuroscience AN - 42219526; 5587995 JF - 39th Annual meeting of the Society for Neuroscience AU - Chiu, C AU - Liu, G AU - Leeds, P AU - Chuang, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Lithium KW - Drugs KW - Animal models KW - Valproic acid KW - Mood KW - Huntington's disease KW - Transgenic mice KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=A+comparative+behavioral+study+of+the+beneficial+effects+of+mood+stabilizing+drugs+lithium+and+valproate+in+transgenic+mouse+models+of+Huntington%27s+disease&rft.au=Chiu%2C+C%3BLiu%2C+G%3BLeeds%2C+P%3BChuang%2C+D&rft.aulast=Chiu&rft.aufirst=C&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serotonin induces an endocannabinoid independent form of long-term depression at corticostriatal synapses T2 - 39th Annual meeting of the Society for Neuroscience AN - 42219515; 5585956 JF - 39th Annual meeting of the Society for Neuroscience AU - Mathur, B N AU - Lovinger, D M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Depression KW - Long-term depression KW - Cannabinoids KW - Cortex KW - Serotonin KW - Synaptic depression KW - Synapses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Serotonin+induces+an+endocannabinoid+independent+form+of+long-term+depression+at+corticostriatal+synapses&rft.au=Mathur%2C+B+N%3BLovinger%2C+D+M&rft.aulast=Mathur&rft.aufirst=B&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Common origin of hippocampal nNOS-expressing-neurogliaform and -ivy interneurons T2 - 39th Annual meeting of the Society for Neuroscience AN - 42219073; 5589242 JF - 39th Annual meeting of the Society for Neuroscience AU - Tricoire, L AU - Miyoshi, G AU - Sousa, V AU - Hjerlingleffler, J AU - Cauli, B AU - Fishell, G AU - Mcbain, C J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Interneurons KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Common+origin+of+hippocampal+nNOS-expressing-neurogliaform+and+-ivy+interneurons&rft.au=Tricoire%2C+L%3BMiyoshi%2C+G%3BSousa%2C+V%3BHjerlingleffler%2C+J%3BCauli%2C+B%3BFishell%2C+G%3BMcbain%2C+C+J&rft.aulast=Tricoire&rft.aufirst=L&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medium conditioned by PA6 cells and identified PA6 cell factors induce dopaminergic neuron differentiation from human embryonic stem cells T2 - 39th Annual meeting of the Society for Neuroscience AN - 42218949; 5589283 JF - 39th Annual meeting of the Society for Neuroscience AU - Schwartz, C M AU - Tavakoli, T AU - Rao, M S AU - Ma, W. AU - Arenas, E AU - Mattson, M P Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Stem cells KW - Differentiation KW - Embryo cells KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Medium+conditioned+by+PA6+cells+and+identified+PA6+cell+factors+induce+dopaminergic+neuron+differentiation+from+human+embryonic+stem+cells&rft.au=Schwartz%2C+C+M%3BTavakoli%2C+T%3BRao%2C+M+S%3BMa%2C+W.%3BArenas%2C+E%3BMattson%2C+M+P&rft.aulast=Schwartz&rft.aufirst=C&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a novel population of cerebellar neurons generated postnatally in lobules VIII and IX T2 - 39th Annual meeting of the Society for Neuroscience AN - 42217563; 5589254 JF - 39th Annual meeting of the Society for Neuroscience AU - Davis, M I AU - Lyman, M T AU - Puhl, III, H. L. AU - Lovinger, D M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Neurogenesis KW - Cerebellum KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42217563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+a+novel+population+of+cerebellar+neurons+generated+postnatally+in+lobules+VIII+and+IX&rft.au=Davis%2C+M+I%3BLyman%2C+M+T%3BPuhl%2C+III%2C+H.+L.%3BLovinger%2C+D+M&rft.aulast=Davis&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Object identification leads to a broadening of conceptual representations T2 - 39th Annual meeting of the Society for Neuroscience AN - 42217225; 5590626 JF - 39th Annual meeting of the Society for Neuroscience AU - Gotts, S AU - Milleville, S AU - Martin, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42217225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Object+identification+leads+to+a+broadening+of+conceptual+representations&rft.au=Gotts%2C+S%3BMilleville%2C+S%3BMartin%2C+A&rft.aulast=Gotts&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of the reward proximity and amount on neuronal signals in rostral part of anterior cingulate cortex in the monkey T2 - 39th Annual meeting of the Society for Neuroscience AN - 42216860; 5587768 JF - 39th Annual meeting of the Society for Neuroscience AU - Toda, K AU - Mizuhiki, T AU - Sugasemiyamoto, Y AU - Inaba, K AU - Ozaki, S AU - Richmond, B J AU - Shidara, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Reinforcement KW - Cortex (cingulate) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+the+reward+proximity+and+amount+on+neuronal+signals+in+rostral+part+of+anterior+cingulate+cortex+in+the+monkey&rft.au=Toda%2C+K%3BMizuhiki%2C+T%3BSugasemiyamoto%2C+Y%3BInaba%2C+K%3BOzaki%2C+S%3BRichmond%2C+B+J%3BShidara%2C+M&rft.aulast=Toda&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of intersegmental sensory influences in the stick insect walking system T2 - 39th Annual meeting of the Society for Neuroscience AN - 42216848; 5587964 JF - 39th Annual meeting of the Society for Neuroscience AU - Borgmann, A AU - Hellekes, K AU - Bueschges, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Insects KW - Walking KW - Aquatic insects KW - Phasmatidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+intersegmental+sensory+influences+in+the+stick+insect+walking+system&rft.au=Borgmann%2C+A%3BHellekes%2C+K%3BBueschges%2C+A&rft.aulast=Borgmann&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural correlates of ultrafast action sequence generation in basal ganglia circuits T2 - 39th Annual meeting of the Society for Neuroscience AN - 42216530; 5588204 JF - 39th Annual meeting of the Society for Neuroscience AU - Jin, X AU - Costa, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Circuits KW - Basal ganglia KW - Ganglia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+correlates+of+ultrafast+action+sequence+generation+in+basal+ganglia+circuits&rft.au=Jin%2C+X%3BCosta%2C+R&rft.aulast=Jin&rft.aufirst=X&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recapitulation of an Nav1.8-like expression pattern in mouse lines carrying an Scn10a promoter driven EGFP reporter transgene T2 - 39th Annual meeting of the Society for Neuroscience AN - 42216231; 5590522 JF - 39th Annual meeting of the Society for Neuroscience AU - Puhl, III, H. AU - Lu, V. AU - Stauffer, B AU - Davis, M AU - Ikeda, S Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Promoters KW - Sodium channels (voltage-gated) KW - Transgenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42216231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Recapitulation+of+an+Nav1.8-like+expression+pattern+in+mouse+lines+carrying+an+Scn10a+promoter+driven+EGFP+reporter+transgene&rft.au=Puhl%2C+III%2C+H.%3BLu%2C+V.%3BStauffer%2C+B%3BDavis%2C+M%3BIkeda%2C+S&rft.aulast=Puhl&rft.aufirst=III&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of sacral neurons involved in activation of the lumbar central pattern generator for locomotion in the neonatal rodent spinal cord T2 - 39th Annual meeting of the Society for Neuroscience AN - 42215909; 5587958 JF - 39th Annual meeting of the Society for Neuroscience AU - Blivis, D AU - Mentis, G AU - O'Donovan, M AU - Lev-Tov, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Neonates KW - Rodents KW - Spinal cord KW - Locomotion KW - Central pattern generator KW - Sacrum KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Studies+of+sacral+neurons+involved+in+activation+of+the+lumbar+central+pattern+generator+for+locomotion+in+the+neonatal+rodent+spinal+cord&rft.au=Blivis%2C+D%3BMentis%2C+G%3BO%27Donovan%2C+M%3BLev-Tov%2C+A&rft.aulast=Blivis&rft.aufirst=D&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of voltage-gated Na+ and Ca2+ channels in zebrafish Rohon-Beard and Dorsal root ganglion sensory neurons T2 - 39th Annual meeting of the Society for Neuroscience AN - 42214997; 5590532 JF - 39th Annual meeting of the Society for Neuroscience AU - Won, Y AU - Chien, C AU - Ono, F AU - Ikeda, S Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Calcium channels KW - Calcium channels (voltage-gated) KW - Sodium channels (voltage-gated) KW - Sensory neurons KW - Dorsal root ganglia KW - Freshwater fish KW - Ganglia KW - Neurons KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+voltage-gated+Na%2B+and+Ca2%2B+channels+in+zebrafish+Rohon-Beard+and+Dorsal+root+ganglion+sensory+neurons&rft.au=Won%2C+Y%3BChien%2C+C%3BOno%2C+F%3BIkeda%2C+S&rft.aulast=Won&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bio-Swarm-Pipeline: A light-weight, extensible batch processing system for efficient biomedical data processing T2 - 39th Annual meeting of the Society for Neuroscience AN - 42214328; 5588485 JF - 39th Annual meeting of the Society for Neuroscience AU - Cheng, X AU - Tong, Y AU - Zoltick, B AU - Luo, Q AU - Weinberger, D R AU - Mattay, V S AU - Pizarro, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Bio-Swarm-Pipeline%3A+A+light-weight%2C+extensible+batch+processing+system+for+efficient+biomedical+data+processing&rft.au=Cheng%2C+X%3BTong%2C+Y%3BZoltick%2C+B%3BLuo%2C+Q%3BWeinberger%2C+D+R%3BMattay%2C+V+S%3BPizarro%2C+R&rft.aulast=Cheng&rft.aufirst=X&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Striatal response to alcohol in heavy drinkers: Can we see tolerance in the brain? T2 - 39th Annual meeting of the Society for Neuroscience AN - 42214280; 5588966 JF - 39th Annual meeting of the Society for Neuroscience AU - Crouss, T AU - Gilman, J AU - Ramchandani, V AU - Hommer, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Alcohols KW - Brain KW - Ethanol KW - Drug tolerance KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Striatal+response+to+alcohol+in+heavy+drinkers%3A+Can+we+see+tolerance+in+the+brain%3F&rft.au=Crouss%2C+T%3BGilman%2C+J%3BRamchandani%2C+V%3BHommer%2C+D&rft.aulast=Crouss&rft.aufirst=T&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Change in 5-HT level in the hippocampus is limited to close proximity of CA3 in CA3-restricted BDNF knockout mice T2 - 39th Annual meeting of the Society for Neuroscience AN - 42213990; 5587579 JF - 39th Annual meeting of the Society for Neuroscience AU - Ito, W AU - Yang, C AU - Yoon, K AU - Huang, Y AU - Morozov, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mice KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Serotonin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Change+in+5-HT+level+in+the+hippocampus+is+limited+to+close+proximity+of+CA3+in+CA3-restricted+BDNF+knockout+mice&rft.au=Ito%2C+W%3BYang%2C+C%3BYoon%2C+K%3BHuang%2C+Y%3BMorozov%2C+A&rft.aulast=Ito&rft.aufirst=W&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and functional synaptic plasticity in nucleus accumbens correlates with locomotor sensitization to cocaine T2 - 39th Annual meeting of the Society for Neuroscience AN - 42213914; 5587848 JF - 39th Annual meeting of the Society for Neuroscience AU - Seabold, G AU - Dobi, A AU - Walton, C AU - Bock, R AU - Alvarez, V Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cocaine KW - Structure-function relationships KW - Plasticity (functional) KW - Nucleus accumbens KW - Plasticity (synaptic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Structural+and+functional+synaptic+plasticity+in+nucleus+accumbens+correlates+with+locomotor+sensitization+to+cocaine&rft.au=Seabold%2C+G%3BDobi%2C+A%3BWalton%2C+C%3BBock%2C+R%3BAlvarez%2C+V&rft.aulast=Seabold&rft.aufirst=G&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential representation of motivational value in sub-regions of monkey ventral prefrontal cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42213635; 5587826 JF - 39th Annual meeting of the Society for Neuroscience AU - Bouret, S AU - Richmond, B J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42213635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+representation+of+motivational+value+in+sub-regions+of+monkey+ventral+prefrontal+cortex&rft.au=Bouret%2C+S%3BRichmond%2C+B+J&rft.aulast=Bouret&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Causal functional network topology in working memory: An MEG study in schizophrenia patients and healthy controls T2 - 39th Annual meeting of the Society for Neuroscience AN - 42212900; 5585821 JF - 39th Annual meeting of the Society for Neuroscience AU - Nadar, S AU - Rutter, L AU - Carver, F AU - Holroyd, T AU - Mitchell-Francis, J AU - Apud, J AU - Weinberger, D AU - Bressler, S AU - Coppola, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mental disorders KW - Schizophrenia KW - Short term memory KW - Magnetoencephalography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42212900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Causal+functional+network+topology+in+working+memory%3A+An+MEG+study+in+schizophrenia+patients+and+healthy+controls&rft.au=Nadar%2C+S%3BRutter%2C+L%3BCarver%2C+F%3BHolroyd%2C+T%3BMitchell-Francis%2C+J%3BApud%2C+J%3BWeinberger%2C+D%3BBressler%2C+S%3BCoppola%2C+R&rft.aulast=Nadar&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heads, shoulders, knees and toes: Highly specific representations of body parts in human extrastriate cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42212889; 5580456 JF - 39th Annual meeting of the Society for Neuroscience AU - Chan, A AU - Kravitz, D AU - Truong, S AU - Arizpe, J AU - Baker, C Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Heads KW - Shoulder KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42212889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Heads%2C+shoulders%2C+knees+and+toes%3A+Highly+specific+representations+of+body+parts+in+human+extrastriate+cortex&rft.au=Chan%2C+A%3BKravitz%2C+D%3BTruong%2C+S%3BArizpe%2C+J%3BBaker%2C+C&rft.aulast=Chan&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The molecular fingerprint of chronically silenced cortical neurons in culture is similar to that of usual brain aging and Alzheimer's disease T2 - 39th Annual meeting of the Society for Neuroscience AN - 42212698; 5585300 JF - 39th Annual meeting of the Society for Neuroscience AU - Gleichmann, M AU - Mughal, M AU - Bruestle, D AU - Chow, V AU - Woods, W AU - Becker, K AU - Pazin, M AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Aging KW - Alzheimer's disease KW - Brain KW - Neurodegenerative diseases KW - Cortex KW - Husbandry diseases KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42212698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+molecular+fingerprint+of+chronically+silenced+cortical+neurons+in+culture+is+similar+to+that+of+usual+brain+aging+and+Alzheimer%27s+disease&rft.au=Gleichmann%2C+M%3BMughal%2C+M%3BBruestle%2C+D%3BChow%2C+V%3BWoods%2C+W%3BBecker%2C+K%3BPazin%2C+M%3BMattson%2C+M&rft.aulast=Gleichmann&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlations between basal ganglia substantia nigra pars reticulata (SNpr) neuronal output and motor activity in a rodent model of Parkinson's disease T2 - 39th Annual meeting of the Society for Neuroscience AN - 42212121; 5588413 JF - 39th Annual meeting of the Society for Neuroscience AU - Avila, I AU - Bergstrom, D AU - Brazhnik, E AU - Parr-Brownlie, L AU - Castaneda, E AU - Walters, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Parkinson's disease KW - Rodents KW - Movement disorders KW - Neurodegenerative diseases KW - Animal models KW - Substantia nigra pars reticulata KW - Basal ganglia KW - Motor activity KW - Ganglia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42212121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Correlations+between+basal+ganglia+substantia+nigra+pars+reticulata+%28SNpr%29+neuronal+output+and+motor+activity+in+a+rodent+model+of+Parkinson%27s+disease&rft.au=Avila%2C+I%3BBergstrom%2C+D%3BBrazhnik%2C+E%3BParr-Brownlie%2C+L%3BCastaneda%2C+E%3BWalters%2C+J&rft.aulast=Avila&rft.aufirst=I&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction of basal progenitor cells in the dorsal telencephalon of monoamine oxidase deficient neonatal mice T2 - 39th Annual meeting of the Society for Neuroscience AN - 42211712; 5585843 JF - 39th Annual meeting of the Society for Neuroscience AU - Cheng, A AU - Scott, A AU - Ladenheim, B AU - Chen, K AU - Ouyang, X AU - Lathia, J AU - Mughal, M AU - Cadet, J AU - Shih, J AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mice KW - Neonates KW - Telencephalon KW - Amine oxidase (flavin-containing) KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Reduction+of+basal+progenitor+cells+in+the+dorsal+telencephalon+of+monoamine+oxidase+deficient+neonatal+mice&rft.au=Cheng%2C+A%3BScott%2C+A%3BLadenheim%2C+B%3BChen%2C+K%3BOuyang%2C+X%3BLathia%2C+J%3BMughal%2C+M%3BCadet%2C+J%3BShih%2C+J%3BMattson%2C+M&rft.aulast=Cheng&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingomyelinases regulate hippocampal CA1 neuron excitability T2 - 39th Annual meeting of the Society for Neuroscience AN - 42211621; 5583561 JF - 39th Annual meeting of the Society for Neuroscience AU - Norman, E AU - Cutler, R AU - Flannery, R AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Excitability KW - Hippocampus KW - Neurons KW - Sphingomyelin phosphodiesterase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Sphingomyelinases+regulate+hippocampal+CA1+neuron+excitability&rft.au=Norman%2C+E%3BCutler%2C+R%3BFlannery%2C+R%3BMattson%2C+M&rft.aulast=Norman&rft.aufirst=E&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic disruption of NMDA receptormediated excitatory inputs onto medial and lateral midbrain dopamine neurons causes dichotomous behavioral consequences in reinforcement learning T2 - 39th Annual meeting of the Society for Neuroscience AN - 42211020; 5587565 JF - 39th Annual meeting of the Society for Neuroscience AU - Cui, G AU - Santos, S S AU - Gerfen, C R AU - Costa, R M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mesencephalon KW - Learning KW - Reinforcement KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Neurons KW - Learning behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+disruption+of+NMDA+receptormediated+excitatory+inputs+onto+medial+and+lateral+midbrain+dopamine+neurons+causes+dichotomous+behavioral+consequences+in+reinforcement+learning&rft.au=Cui%2C+G%3BSantos%2C+S+S%3BGerfen%2C+C+R%3BCosta%2C+R+M&rft.aulast=Cui&rft.aufirst=G&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell-type specific effect o fthe KK385/386AA mutation on ethanol potentiation of glycine alpha1 receptors expressed in xenopus oocytes and HEK-293 cells T2 - 39th Annual meeting of the Society for Neuroscience AN - 42210462; 5578914 JF - 39th Annual meeting of the Society for Neuroscience AU - Zhang, L AU - Xiong, W AU - Lovinger, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Ethanol KW - Mutation KW - Oocytes KW - Glycine KW - Potentiation KW - Amphibiotic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42210462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Cell-type+specific+effect+o+fthe+KK385%2F386AA+mutation+on+ethanol+potentiation+of+glycine+alpha1+receptors+expressed+in+xenopus+oocytes+and+HEK-293+cells&rft.au=Zhang%2C+L%3BXiong%2C+W%3BLovinger%2C+D&rft.aulast=Zhang&rft.aufirst=L&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased, local amplitude fluctuations and reduced, global synchronization characterizes left prefrontal cortex (IPFC) resting activity in patients with schizophrenia T2 - 39th Annual meeting of the Society for Neuroscience AN - 42210110; 5585875 JF - 39th Annual meeting of the Society for Neuroscience AU - Gireesh, E AU - Nadar, S AU - Carver, F AU - Holroyd, T AU - Mitchell-Francis, J AU - Apud, J AU - Weinberger, D AU - Coppola, R AU - Plenz, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mental disorders KW - Schizophrenia KW - Synchronization KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42210110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Increased%2C+local+amplitude+fluctuations+and+reduced%2C+global+synchronization+characterizes+left+prefrontal+cortex+%28IPFC%29+resting+activity+in+patients+with+schizophrenia&rft.au=Gireesh%2C+E%3BNadar%2C+S%3BCarver%2C+F%3BHolroyd%2C+T%3BMitchell-Francis%2C+J%3BApud%2C+J%3BWeinberger%2C+D%3BCoppola%2C+R%3BPlenz%2C+D&rft.aulast=Gireesh&rft.aufirst=E&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of synaptic plasticity in entorhinal cortex by nicotine T2 - 39th Annual meeting of the Society for Neuroscience AN - 42208366; 5586438 JF - 39th Annual meeting of the Society for Neuroscience AU - Gu, Z. AU - Tu, B. AU - Yakel, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Nicotine KW - Cortex (entorhinal) KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42208366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+synaptic+plasticity+in+entorhinal+cortex+by+nicotine&rft.au=Gu%2C+Z.%3BTu%2C+B.%3BYakel%2C+J&rft.aulast=Gu&rft.aufirst=Z.&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The functional connectivity of cortical brain areas subserving spatial stimulus-response compatibility T2 - 39th Annual meeting of the Society for Neuroscience AN - 42207710; 5584562 JF - 39th Annual meeting of the Society for Neuroscience AU - Mooshagian, E F AU - Greene, D J AU - Kaplan, J T AU - Zaidel, E AU - Iacoboni, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Brain KW - Cortex KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42207710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+functional+connectivity+of+cortical+brain+areas+subserving+spatial+stimulus-response+compatibility&rft.au=Mooshagian%2C+E+F%3BGreene%2C+D+J%3BKaplan%2C+J+T%3BZaidel%2C+E%3BIacoboni%2C+M&rft.aulast=Mooshagian&rft.aufirst=E&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive phenotyping reveals the true identities of neural stem cells and intermediate progenitors and resolves their ontogenetically changing lineage progressions underlying cortical neurogenesis T2 - 39th Annual meeting of the Society for Neuroscience AN - 42207164; 5578147 JF - 39th Annual meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y AU - Barker, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Stem cells KW - Neural stem cells KW - Neurogenesis KW - Phenotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42207164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Comprehensive+phenotyping+reveals+the+true+identities+of+neural+stem+cells+and+intermediate+progenitors+and+resolves+their+ontogenetically+changing+lineage+progressions+underlying+cortical+neurogenesis&rft.au=Maric%2C+D%3BChang%2C+Y%3BBarker%2C+J&rft.aulast=Maric&rft.aufirst=D&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early postnata lNMDA receptor ablation in corticolimbic GABAergic interneurons results in decreased GAD67 expression and an uncoordinated increase of pyramidal cell activity in vivo. T2 - 39th Annual meeting of the Society for Neuroscience AN - 42207149; 5580361 JF - 39th Annual meeting of the Society for Neuroscience AU - Belforte, J AU - Nakazawa, K Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Pyramidal cells KW - Interneurons KW - G-Aminobutyric acid KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42207149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Early+postnata+lNMDA+receptor+ablation+in+corticolimbic+GABAergic+interneurons+results+in+decreased+GAD67+expression+and+an+uncoordinated+increase+of+pyramidal+cell+activity+in+vivo.&rft.au=Belforte%2C+J%3BNakazawa%2C+K&rft.aulast=Belforte&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cerebrovascular protection by dietary energy restriction involves increased cellular stress resistance and reduced inflammation, and is attenuated in aging T2 - 39th Annual meeting of the Society for Neuroscience AN - 42207111; 5584364 JF - 39th Annual meeting of the Society for Neuroscience AU - Wan, R AU - Arumugam, T AU - Phillips, T AU - Cheng, A AU - Morrell, C AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Aging KW - Diets KW - Stress KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42207111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Cerebrovascular+protection+by+dietary+energy+restriction+involves+increased+cellular+stress+resistance+and+reduced+inflammation%2C+and+is+attenuated+in+aging&rft.au=Wan%2C+R%3BArumugam%2C+T%3BPhillips%2C+T%3BCheng%2C+A%3BMorrell%2C+C%3BMattson%2C+M&rft.aulast=Wan&rft.aufirst=R&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding Neurogenetic Mechanisms in Neuropsychiatric Conditions: Lessons from Williams Syndrome T2 - 39th Annual meeting of the Society for Neuroscience AN - 42206518; 5579537 JF - 39th Annual meeting of the Society for Neuroscience AU - Berman, K Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Williams syndrome KW - Neurogenetics KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Understanding+Neurogenetic+Mechanisms+in+Neuropsychiatric+Conditions%3A+Lessons+from+Williams+Syndrome&rft.au=Berman%2C+K&rft.aulast=Berman&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curcumin treatment alleviates cognitive impairment elicited by inflammation T2 - 39th Annual meeting of the Society for Neuroscience AN - 42206434; 5584475 JF - 39th Annual meeting of the Society for Neuroscience AU - Kawamoto, E AU - Camandola, S AU - Mughal, M AU - Scavone, C AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cognitive ability KW - Curcumin KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Curcumin+treatment+alleviates+cognitive+impairment+elicited+by+inflammation&rft.au=Kawamoto%2C+E%3BCamandola%2C+S%3BMughal%2C+M%3BScavone%2C+C%3BMattson%2C+M&rft.aulast=Kawamoto&rft.aufirst=E&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Motion processing in the monkey pulvinar pathway from superior colliculus to cortical area MT T2 - 39th Annual meeting of the Society for Neuroscience AN - 42206301; 5586557 JF - 39th Annual meeting of the Society for Neuroscience AU - Berman, R AU - Wurtz, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Superior colliculus KW - Motion detection KW - Cortex KW - Pulvinar KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Motion+processing+in+the+monkey+pulvinar+pathway+from+superior+colliculus+to+cortical+area+MT&rft.au=Berman%2C+R%3BWurtz%2C+R&rft.aulast=Berman&rft.aufirst=R&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations of PDE4D expression in postmortem brain tissue from subjects with affective disorders T2 - 39th Annual meeting of the Society for Neuroscience AN - 42206230; 5580693 JF - 39th Annual meeting of the Society for Neuroscience AU - Guitart, X AU - Yuan, P AU - Austin, D AU - Zhou, R AU - Wang, Y AU - Manji, H AU - Chen, G Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Brain KW - Phosphodiesterase KW - Affective disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Alterations+of+PDE4D+expression+in+postmortem+brain+tissue+from+subjects+with+affective+disorders&rft.au=Guitart%2C+X%3BYuan%2C+P%3BAustin%2C+D%3BZhou%2C+R%3BWang%2C+Y%3BManji%2C+H%3BChen%2C+G&rft.aulast=Guitart&rft.aufirst=X&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of behavioral context on information encoding by local field potentials in the rostral supratemporal plane T2 - 39th Annual meeting of the Society for Neuroscience AN - 42206048; 5580400 JF - 39th Annual meeting of the Society for Neuroscience AU - Fukushima, M AU - Scott, B AU - Vinal, H AU - Yin, P AU - Mishkin, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Electrophysiological recording KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+behavioral+context+on+information+encoding+by+local+field+potentials+in+the+rostral+supratemporal+plane&rft.au=Fukushima%2C+M%3BScott%2C+B%3BVinal%2C+H%3BYin%2C+P%3BMishkin%2C+M&rft.aulast=Fukushima&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of direct geniculate input to-V1independent fMRI activation of macaque extrastriate cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42205815; 5580491 JF - 39th Annual meeting of the Society for Neuroscience AU - Schmid, M AU - Mrowka, S AU - Turchi, J AU - Wilke, M AU - Ye, F. AU - Saunders, R AU - Leopold, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Functional magnetic resonance imaging KW - Cortex (visual) KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42205815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Contribution+of+direct+geniculate+input+to-V1independent+fMRI+activation+of+macaque+extrastriate+cortex&rft.au=Schmid%2C+M%3BMrowka%2C+S%3BTurchi%2C+J%3BWilke%2C+M%3BYe%2C+F.%3BSaunders%2C+R%3BLeopold%2C+D&rft.aulast=Schmid&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuregulin3 (NRG3) genetic variations and susceptibility to schizophrenia T2 - 39th Annual meeting of the Society for Neuroscience AN - 42205558; 5582747 JF - 39th Annual meeting of the Society for Neuroscience AU - Law, A J AU - Kao, K W AU - Weinberger, D R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mental disorders KW - Genetic diversity KW - Schizophrenia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42205558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuregulin3+%28NRG3%29+genetic+variations+and+susceptibility+to+schizophrenia&rft.au=Law%2C+A+J%3BKao%2C+K+W%3BWeinberger%2C+D+R&rft.aulast=Law&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A simple, highly efficient method for heterologous expression in mouse primary neurons using cationic lipid-mediated mRNA transfection T2 - 39th Annual meeting of the Society for Neuroscience AN - 42205124; 5585090 JF - 39th Annual meeting of the Society for Neuroscience AU - Williams, D AU - Puhl III, H AU - Ikeda, S Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - MRNA KW - Neurons KW - Transfection KW - Cations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42205124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=A+simple%2C+highly+efficient+method+for+heterologous+expression+in+mouse+primary+neurons+using+cationic+lipid-mediated+mRNA+transfection&rft.au=Williams%2C+D%3BPuhl+III%2C+H%3BIkeda%2C+S&rft.aulast=Williams&rft.aufirst=D&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic regulation of cortical gene expression across the human lifespan T2 - 39th Annual meeting of the Society for Neuroscience AN - 42204863; 5586113 JF - 39th Annual meeting of the Society for Neuroscience AU - Lipska, B AU - Ye, T. AU - Tao, R AU - Elkahloun, A AU - Hyde, T AU - Weinberger, D AU - Kleinman, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Gene expression KW - Cortex KW - Life span KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42204863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+regulation+of+cortical+gene+expression+across+the+human+lifespan&rft.au=Lipska%2C+B%3BYe%2C+T.%3BTao%2C+R%3BElkahloun%2C+A%3BHyde%2C+T%3BWeinberger%2C+D%3BKleinman%2C+J&rft.aulast=Lipska&rft.aufirst=B&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Snapin-dynein-mediated coordination of transport and membrane trafficking in regulating neuronal autophagy-lysosomal function T2 - 39th Annual meeting of the Society for Neuroscience AN - 42204444; 5582572 JF - 39th Annual meeting of the Society for Neuroscience AU - Cai, Q AU - Lu, L. AU - Tian, J AU - Zhu, Y AU - Sheng, Z Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Trafficking KW - Membranes KW - Membrane trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42204444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Snapin-dynein-mediated+coordination+of+transport+and+membrane+trafficking+in+regulating+neuronal+autophagy-lysosomal+function&rft.au=Cai%2C+Q%3BLu%2C+L.%3BTian%2C+J%3BZhu%2C+Y%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The alpha7 nicotinic acetylcholine receptor modulates the effects of low doses of nicotine upon dopamine release in the striatum T2 - 39th Annual meeting of the Society for Neuroscience AN - 42204287; 5586507 JF - 39th Annual meeting of the Society for Neuroscience AU - Seipel, A AU - Yakel, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Nicotine KW - Acetylcholine receptors (nicotinic) KW - Neostriatum KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42204287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+alpha7+nicotinic+acetylcholine+receptor+modulates+the+effects+of+low+doses+of+nicotine+upon+dopamine+release+in+the+striatum&rft.au=Seipel%2C+A%3BYakel%2C+J&rft.aulast=Seipel&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unusual ultrasonic vocalizations in adult BTBR mice during three types of social encounters T2 - 39th Annual meeting of the Society for Neuroscience AN - 42203790; 5583192 JF - 39th Annual meeting of the Society for Neuroscience AU - Scattoni, M AU - Ricceri, L AU - Crawley, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Ultrasonics KW - Mice KW - Vocalization behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42203790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Unusual+ultrasonic+vocalizations+in+adult+BTBR+mice+during+three+types+of+social+encounters&rft.au=Scattoni%2C+M%3BRicceri%2C+L%3BCrawley%2C+J&rft.aulast=Scattoni&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The subunit composition of post-synaptic kainate receptors in layer IV of the developing barrel cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42203529; 5586742 JF - 39th Annual meeting of the Society for Neuroscience AU - Sherwood, J AU - Jouhanneau, J AU - Isaac, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cortex (somatosensory) KW - Glutamic acid receptors KW - Subunit structure KW - Cortex (barrel) KW - Kainic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42203529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+subunit+composition+of+post-synaptic+kainate+receptors+in+layer+IV+of+the+developing+barrel+cortex&rft.au=Sherwood%2C+J%3BJouhanneau%2C+J%3BIsaac%2C+J&rft.aulast=Sherwood&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bi-directional functions of proBDNF/mBDNF in synaptic plasticity and cognitive functions T2 - 39th Annual meeting of the Society for Neuroscience AN - 42203079; 5579561 JF - 39th Annual meeting of the Society for Neuroscience AU - Lu, B. Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cognitive ability KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42203079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Bi-directional+functions+of+proBDNF%2FmBDNF+in+synaptic+plasticity+and+cognitive+functions&rft.au=Lu%2C+B.&rft.aulast=Lu&rft.aufirst=B.&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II AT1 receptor blockade reduces the innate inflammatory response to lipopolysaccharide in the rat hypothalamus T2 - 39th Annual meeting of the Society for Neuroscience AN - 42202962; 5582355 JF - 39th Annual meeting of the Society for Neuroscience AU - Benicky, J AU - Sanchez-Lemus, E AU - Pavel, J AU - Aguilera, G AU - Saavedra, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Lipopolysaccharides KW - Inflammation KW - Angiotensin II KW - Hypothalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42202962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+AT1+receptor+blockade+reduces+the+innate+inflammatory+response+to+lipopolysaccharide+in+the+rat+hypothalamus&rft.au=Benicky%2C+J%3BSanchez-Lemus%2C+E%3BPavel%2C+J%3BAguilera%2C+G%3BSaavedra%2C+J&rft.aulast=Benicky&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Excitotoxic NMDA induces differential calcium overload-dependent mitochondrial dysfunction in CA1 and CA3 hippocampal neurons T2 - 39th Annual meeting of the Society for Neuroscience AN - 42202223; 5584350 JF - 39th Annual meeting of the Society for Neuroscience AU - Stanika, R AU - Winters, C AU - Brantner, C AU - Pivovarova, N AU - Andrews, B Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Calcium KW - Excitotoxicity KW - Mitochondria KW - Calcium (mitochondrial) KW - N-Methyl-D-aspartic acid KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42202223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Excitotoxic+NMDA+induces+differential+calcium+overload-dependent+mitochondrial+dysfunction+in+CA1+and+CA3+hippocampal+neurons&rft.au=Stanika%2C+R%3BWinters%2C+C%3BBrantner%2C+C%3BPivovarova%2C+N%3BAndrews%2C+B&rft.aulast=Stanika&rft.aufirst=R&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased gene expression of diacylglycerol kinase eta in bipolar disorder T2 - 39th Annual meeting of the Society for Neuroscience AN - 42202129; 5582864 JF - 39th Annual meeting of the Society for Neuroscience AU - Moya, P R AU - Laporte, J AU - Wendland, J R AU - Mcmahon, F AU - Cabanero, M AU - Murphy, D L Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Gene expression KW - Diacylglycerol kinase KW - Bipolar disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42202129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Increased+gene+expression+of+diacylglycerol+kinase+eta+in+bipolar+disorder&rft.au=Moya%2C+P+R%3BLaporte%2C+J%3BWendland%2C+J+R%3BMcmahon%2C+F%3BCabanero%2C+M%3BMurphy%2C+D+L&rft.aulast=Moya&rft.aufirst=P&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chloride transporters underlie synaptic scaling of GABAergic mPSCs in the embryonic spinal cord T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201982; 5579886 JF - 39th Annual meeting of the Society for Neuroscience AU - Chub, N AU - Gonzalez-Islas, C E AU - Lee, S AU - Choi, I AU - Wenner, P Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Chloride KW - Scaling KW - Spinal cord KW - Embryos KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Chloride+transporters+underlie+synaptic+scaling+of+GABAergic+mPSCs+in+the+embryonic+spinal+cord&rft.au=Chub%2C+N%3BGonzalez-Islas%2C+C+E%3BLee%2C+S%3BChoi%2C+I%3BWenner%2C+P&rft.aulast=Chub&rft.aufirst=N&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of alternate transcripts of cation chloride cotransporter NKCC1 (SLC12A2) in human brain T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201715; 5582749 JF - 39th Annual meeting of the Society for Neuroscience AU - Morita, Y AU - Tao, R AU - Hyde, T M AU - Newburn, E N AU - Lipska, B K AU - Weinberger, D R AU - Kleinman, J E AU - Ali, T Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Chloride KW - Cations KW - Brain KW - Chloride transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+alternate+transcripts+of+cation+chloride+cotransporter+NKCC1+%28SLC12A2%29+in+human+brain&rft.au=Morita%2C+Y%3BTao%2C+R%3BHyde%2C+T+M%3BNewburn%2C+E+N%3BLipska%2C+B+K%3BWeinberger%2C+D+R%3BKleinman%2C+J+E%3BAli%2C+T&rft.aulast=Morita&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuralactivityoffrontostriatalcircuits mediating shifts between goal-directed actions and habits T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201478; 5583845 JF - 39th Annual meeting of the Society for Neuroscience AU - Gremel, C AU - Costa, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuralactivityoffrontostriatalcircuits+mediating+shifts+between+goal-directed+actions+and+habits&rft.au=Gremel%2C+C%3BCosta%2C+R&rft.aulast=Gremel&rft.aufirst=C&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ca2+ initiates all forms of endocytosis during depolarization at a nerve terminal T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201443; 5582602 JF - 39th Annual meeting of the Society for Neuroscience AU - Wu, L. AU - Mcneil, B AU - Wu, X. AU - Xu, J. AU - Fan, J AU - Xu, L. AU - Melicoff, E AU - Adachi, R AU - Bai, L Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Endocytosis KW - Nerve endings KW - Calcium KW - Nerves KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Ca2%2B+initiates+all+forms+of+endocytosis+during+depolarization+at+a+nerve+terminal&rft.au=Wu%2C+L.%3BMcneil%2C+B%3BWu%2C+X.%3BXu%2C+J.%3BFan%2C+J%3BXu%2C+L.%3BMelicoff%2C+E%3BAdachi%2C+R%3BBai%2C+L&rft.aulast=Wu&rft.aufirst=L.&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - lnterneuronal ErbB4 receptor ablation alters GABAergic inhibition in pyramidal cells T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201331; 5580296 JF - 39th Annual meeting of the Society for Neuroscience AU - Zsiros, V AU - Belforte, J AU - Lloyd, K AU - Nakazawa, K Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Pyramidal cells KW - ErbB-2 protein KW - G-Aminobutyric acid KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=lnterneuronal+ErbB4+receptor+ablation+alters+GABAergic+inhibition+in+pyramidal+cells&rft.au=Zsiros%2C+V%3BBelforte%2C+J%3BLloyd%2C+K%3BNakazawa%2C+K&rft.aulast=Zsiros&rft.aufirst=V&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICRAC-like store operated calcium entry in rat intracardiac neurons T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201164; 5582709 JF - 39th Annual meeting of the Society for Neuroscience AU - Cuevas, J AU - Katnik, C AU - Bonds, T AU - Dehaven, W Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Calcium KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=ICRAC-like+store+operated+calcium+entry+in+rat+intracardiac+neurons&rft.au=Cuevas%2C+J%3BKatnik%2C+C%3BBonds%2C+T%3BDehaven%2C+W&rft.aulast=Cuevas&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral changes in adult mice lacking ErbB4: Implications for psychiatric disorders T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201109; 5583245 JF - 39th Annual meeting of the Society for Neuroscience AU - Shamir, A AU - Buonanno, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mental disorders KW - Mice KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+changes+in+adult+mice+lacking+ErbB4%3A+Implications+for+psychiatric+disorders&rft.au=Shamir%2C+A%3BBuonanno%2C+A&rft.aulast=Shamir&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice T2 - 39th Annual meeting of the Society for Neuroscience AN - 42201068; 5583243 JF - 39th Annual meeting of the Society for Neuroscience AU - Neddens, J AU - Buonanno, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mice KW - ErbB-2 protein KW - Interneurons KW - Hippocampus KW - Quantitative distribution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+populations+of+hippocampal+interneurons+express+ErbB4+and+their+number+and+distribution+is+altered+in+ErbB4+knockout+mice&rft.au=Neddens%2C+J%3BBuonanno%2C+A&rft.aulast=Neddens&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 5-HT receptor 3 modulates gamma oscillations by regulating spike frequency and precision in fast-spiking parvalbumin-positive interneurons T2 - 39th Annual meeting of the Society for Neuroscience AN - 42199448; 5583455 JF - 39th Annual meeting of the Society for Neuroscience AU - Huang, Y AU - Ito, W AU - Yoon, K AU - Jiao, S AU - Morozov, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Interneurons KW - Oscillations KW - Serotonin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42199448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=5-HT+receptor+3+modulates+gamma+oscillations+by+regulating+spike+frequency+and+precision+in+fast-spiking+parvalbumin-positive+interneurons&rft.au=Huang%2C+Y%3BIto%2C+W%3BYoon%2C+K%3BJiao%2C+S%3BMorozov%2C+A&rft.aulast=Huang&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel approaches to resolve the localization of ErbB4 in the hippocampus T2 - 39th Annual meeting of the Society for Neuroscience AN - 42199206; 5583246 JF - 39th Annual meeting of the Society for Neuroscience AU - Vullhorst, D AU - Neddens, J AU - Karavanova, I AU - Tricoire, L AU - McBain, C AU - Petralia, R AU - Buonanno, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - ErbB-2 protein KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42199206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Novel+approaches+to+resolve+the+localization+of+ErbB4+in+the+hippocampus&rft.au=Vullhorst%2C+D%3BNeddens%2C+J%3BKaravanova%2C+I%3BTricoire%2C+L%3BMcBain%2C+C%3BPetralia%2C+R%3BBuonanno%2C+A&rft.aulast=Vullhorst&rft.aufirst=D&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes independently of Angiotensin II AT1 receptor blockade T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198986; 5582329 JF - 39th Annual meeting of the Society for Neuroscience AU - Pang, T AU - Benicky, J AU - Sanchez-Lemus, E AU - Honda, M AU - Saavedra, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Immune response KW - Monocytes KW - Lipopolysaccharides KW - Angiotensin II KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Candesartan+reduces+the+innate+immune+response+to+lipopolysaccharide+in+human+monocytes+independently+of+Angiotensin+II+AT1+receptor+blockade&rft.au=Pang%2C+T%3BBenicky%2C+J%3BSanchez-Lemus%2C+E%3BHonda%2C+M%3BSaavedra%2C+J&rft.aulast=Pang&rft.aufirst=T&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol potentiation of GABAergic synaptic transmission modulated by 5-HT3 receptors in neuron/bouton preparations from rat hippocampal CA1 region T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198706; 5582820 JF - 39th Annual meeting of the Society for Neuroscience AU - Jun, S AU - Talani, G AU - Ikeda, S AU - Lovinger, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Ethanol KW - Presynapse KW - Synaptic transmission KW - Potentiation KW - Hippocampus KW - Serotonin S3 receptors KW - G-Aminobutyric acid KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Ethanol+potentiation+of+GABAergic+synaptic+transmission+modulated+by+5-HT3+receptors+in+neuron%2Fbouton+preparations+from+rat+hippocampal+CA1+region&rft.au=Jun%2C+S%3BTalani%2C+G%3BIkeda%2C+S%3BLovinger%2C+D&rft.aulast=Jun&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic variation in CACNAIC predicts brain circuitries related to mental illness T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198555; 5582772 JF - 39th Annual meeting of the Society for Neuroscience AU - Bigos, K L AU - Mattay, V S AU - Callicott, J H AU - Vakkalanka, R AU - Weinberger, D R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mental disorders KW - Brain KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+variation+in+CACNAIC+predicts+brain+circuitries+related+to+mental+illness&rft.au=Bigos%2C+K+L%3BMattay%2C+V+S%3BCallicott%2C+J+H%3BVakkalanka%2C+R%3BWeinberger%2C+D+R&rft.aulast=Bigos&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Addiction and Self-Control T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198233; 5576528 JF - 39th Annual meeting of the Society for Neuroscience AU - Volkow, Nora Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Addiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Addiction+and+Self-Control&rft.au=Volkow%2C+Nora&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential binding of CaM to Group 1 mGluRs and its role in receptor trafficking T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198145; 5582084 JF - 39th Annual meeting of the Society for Neuroscience AU - Choi, K AU - Roche, K Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Trafficking KW - Protein transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+binding+of+CaM+to+Group+1+mGluRs+and+its+role+in+receptor+trafficking&rft.au=Choi%2C+K%3BRoche%2C+K&rft.aulast=Choi&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic basis for serotonin-based neurotoxic reactions: Evidence from gene-targeted mouse models T2 - 39th Annual meeting of the Society for Neuroscience AN - 42198117; 5582521 JF - 39th Annual meeting of the Society for Neuroscience AU - Fox, M AU - Murphy, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Neurotoxicity KW - Animal models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42198117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+basis+for+serotonin-based+neurotoxic+reactions%3A+Evidence+from+gene-targeted+mouse+models&rft.au=Fox%2C+M%3BMurphy%2C+D&rft.aulast=Fox&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The distribution and mobility of SAP102 in spines T2 - 39th Annual meeting of the Society for Neuroscience AN - 42197655; 5581498 JF - 39th Annual meeting of the Society for Neuroscience AU - Zheng, C AU - Petralia, R AU - Wang, Y AU - Kachar, B AU - Wenthold, R Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Spine KW - Mobility KW - Spines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+distribution+and+mobility+of+SAP102+in+spines&rft.au=Zheng%2C+C%3BPetralia%2C+R%3BWang%2C+Y%3BKachar%2C+B%3BWenthold%2C+R&rft.aulast=Zheng&rft.aufirst=C&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional alpha7 nicotinic acetylcholine receptors on astrocytes of the CA1 region in rat hippocampal slices T2 - 39th Annual meeting of the Society for Neuroscience AN - 42197321; 5583096 JF - 39th Annual meeting of the Society for Neuroscience AU - Shen, J AU - Yakel, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Acetylcholine receptors (nicotinic) KW - Brain slice preparation KW - Astrocytes KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+alpha7+nicotinic+acetylcholine+receptors+on+astrocytes+of+the+CA1+region+in+rat+hippocampal+slices&rft.au=Shen%2C+J%3BYakel%2C+J&rft.aulast=Shen&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Valuation of abstract concepts by macaque monkeys T2 - 39th Annual meeting of the Society for Neuroscience AN - 42197232; 5576371 JF - 39th Annual meeting of the Society for Neuroscience AU - Howland, E AU - Murray, E Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Valuation+of+abstract+concepts+by+macaque+monkeys&rft.au=Howland%2C+E%3BMurray%2C+E&rft.aulast=Howland&rft.aufirst=E&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKA phosphorylation is required for enhanced surface expression of Kv4.2/KChlP4a channel complexes T2 - 39th Annual meeting of the Society for Neuroscience AN - 42197136; 5582987 JF - 39th Annual meeting of the Society for Neuroscience AU - Lin, L AU - Sun, W AU - Wikenheiser, A AU - Kung, F AU - Hoffman, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Channels KW - Protein kinase A KW - Potassium channels (voltage-gated) KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=PKA+phosphorylation+is+required+for+enhanced+surface+expression+of+Kv4.2%2FKChlP4a+channel+complexes&rft.au=Lin%2C+L%3BSun%2C+W%3BWikenheiser%2C+A%3BKung%2C+F%3BHoffman%2C+D&rft.aulast=Lin&rft.aufirst=L&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reacting faster to fearful than neutral faces correlates with harm avoidance and activity in the medial prefrontal cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42197087; 5576225 JF - 39th Annual meeting of the Society for Neuroscience AU - Doty, T AU - Japee, S AU - Ingvar, M AU - Ungerleider, L Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cortex (prefrontal) KW - Avoidance reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Reacting+faster+to+fearful+than+neutral+faces+correlates+with+harm+avoidance+and+activity+in+the+medial+prefrontal+cortex&rft.au=Doty%2C+T%3BJapee%2C+S%3BIngvar%2C+M%3BUngerleider%2C+L&rft.aulast=Doty&rft.aufirst=T&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exit of calmodulin from soma (nucleus)and its association with neurogranin in dendritic spines leads to the expression of LTP T2 - 39th Annual meeting of the Society for Neuroscience AN - 42196806; 5583182 JF - 39th Annual meeting of the Society for Neuroscience AU - Huang, K AU - Huang, F Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Dendritic spines KW - Long-term potentiation KW - Calmodulin KW - Neurogranin KW - Calcium-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42196806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Exit+of+calmodulin+from+soma+%28nucleus%29and+its+association+with+neurogranin+in+dendritic+spines+leads+to+the+expression+of+LTP&rft.au=Huang%2C+K%3BHuang%2C+F&rft.aulast=Huang&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TH17-mediated activation of matrix metalloproteinases disrupts the blood brain barrier in a mouse model of INCL. T2 - 39th Annual meeting of the Society for Neuroscience AN - 42196798; 5577325 JF - 39th Annual meeting of the Society for Neuroscience AU - Saha, A AU - Munasinghe, J AU - Zhang, Z AU - Heffer, A AU - Mukherjee, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Brain KW - Animal models KW - Matrix metalloproteinase KW - Blood-brain barrier KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42196798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=TH17-mediated+activation+of+matrix+metalloproteinases+disrupts+the+blood+brain+barrier+in+a+mouse+model+of+INCL.&rft.au=Saha%2C+A%3BMunasinghe%2C+J%3BZhang%2C+Z%3BHeffer%2C+A%3BMukherjee%2C+A&rft.aulast=Saha&rft.aufirst=A&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - G-protein-coupled receptor modulation of N-type Ca2+ channels is differentially affected in sympathetic neurons from RGS7 mutant mice, Rgs7tm1Lex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42196793; 5579087 JF - 39th Annual meeting of the Society for Neuroscience AU - Lu, V. AU - Zhang, J AU - Simonds, W AU - Ikeda, S Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Calcium channels KW - Mice KW - Mutants KW - Calcium channels (N-type) KW - Sympathetic nerves KW - G protein-coupled receptors KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42196793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=G-protein-coupled+receptor+modulation+of+N-type+Ca2%2B+channels+is+differentially+affected+in+sympathetic+neurons+from+RGS7+mutant+mice%2C+Rgs7tm1Lex&rft.au=Lu%2C+V.%3BZhang%2C+J%3BSimonds%2C+W%3BIkeda%2C+S&rft.aulast=Lu&rft.aufirst=V.&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations in goal directed behavior but not emotion following excitotoxic lesions in distinct subregions of macaque orbitofrontal cortex T2 - 39th Annual meeting of the Society for Neuroscience AN - 42196381; 5576366 JF - 39th Annual meeting of the Society for Neuroscience AU - Rudebeck, P AU - Chau, L AU - Murray, E Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Lesions KW - Excitotoxicity KW - Emotions KW - Cortex KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42196381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Alterations+in+goal+directed+behavior+but+not+emotion+following+excitotoxic+lesions+in+distinct+subregions+of+macaque+orbitofrontal+cortex&rft.au=Rudebeck%2C+P%3BChau%2C+L%3BMurray%2C+E&rft.aulast=Rudebeck&rft.aufirst=P&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired ERAD and ER stressare specific events associated with dystonia T2 - 39th Annual meeting of the Society for Neuroscience AN - 42196013; 5575400 JF - 39th Annual meeting of the Society for Neuroscience AU - Nery, F AU - Farley, J AU - Ye, Y. AU - Tannous, B AU - Breakefield, X Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Dystonia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42196013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Impaired+ERAD+and+ER+stressare+specific+events+associated+with+dystonia&rft.au=Nery%2C+F%3BFarley%2C+J%3BYe%2C+Y.%3BTannous%2C+B%3BBreakefield%2C+X&rft.aulast=Nery&rft.aufirst=F&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral and neurochemical differences between Drd1-GFP and Drd2-GFP mice and their response to acute and chronic cocaine exposure T2 - 39th Annual meeting of the Society for Neuroscience AN - 42195593; 5579352 JF - 39th Annual meeting of the Society for Neuroscience AU - Mateo, Y AU - Walton, C AU - Dobi, A AU - Alvarez, V Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Mice KW - Cocaine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42195593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+and+neurochemical+differences+between+Drd1-GFP+and+Drd2-GFP+mice+and+their+response+to+acute+and+chronic+cocaine+exposure&rft.au=Mateo%2C+Y%3BWalton%2C+C%3BDobi%2C+A%3BAlvarez%2C+V&rft.aulast=Mateo&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of immediate early transcription in synaptic plasticity T2 - 39th Annual meeting of the Society for Neuroscience AN - 42195337; 5577425 JF - 39th Annual meeting of the Society for Neuroscience AU - Saha, R AU - Wissink, E AU - Dudek, S Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Transcription KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42195337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Mechanism+of+immediate+early+transcription+in+synaptic+plasticity&rft.au=Saha%2C+R%3BWissink%2C+E%3BDudek%2C+S&rft.aulast=Saha&rft.aufirst=R&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - P53 mediates hippocampal LTP,butis dispensable for hippocampal learning and memory tasks T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194908; 5579731 JF - 39th Annual meeting of the Society for Neuroscience AU - Flannery, R AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Hippocampus KW - Learning KW - P53 protein KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=P53+mediates+hippocampal+LTP%2Cbutis+dispensable+for+hippocampal+learning+and+memory+tasks&rft.au=Flannery%2C+R%3BMattson%2C+M&rft.aulast=Flannery&rft.aufirst=R&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lesions of area 25(infralimbic cortex)in rhesus monkeys fail to disrupt spontaneous recovery of an extinguished response T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194609; 5576365 JF - 39th Annual meeting of the Society for Neuroscience AU - Rhodes, S AU - Daniels, T AU - Chudasama, Y AU - Murray, E Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Lesions KW - Spontaneous recovery KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Lesions+of+area+25%28infralimbic+cortex%29in+rhesus+monkeys+fail+to+disrupt+spontaneous+recovery+of+an+extinguished+response&rft.au=Rhodes%2C+S%3BDaniels%2C+T%3BChudasama%2C+Y%3BMurray%2C+E&rft.aulast=Rhodes&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic interaction between COMT and Dysbindin produce schizophrenia-like phenotypes T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194512; 5578934 JF - 39th Annual meeting of the Society for Neuroscience AU - Papaleo, F AU - Chen, J AU - Lu, B. AU - Crawley, J AU - Weinberger, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+interaction+between+COMT+and+Dysbindin+produce+schizophrenia-like+phenotypes&rft.au=Papaleo%2C+F%3BChen%2C+J%3BLu%2C+B.%3BCrawley%2C+J%3BWeinberger%2C+D&rft.aulast=Papaleo&rft.aufirst=F&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The iron-regulating protein ceruloplasmin protects brain cells in a mouse model of ischemic stroke T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194378; 5578584 JF - 39th Annual meeting of the Society for Neuroscience AU - Texel, S AU - Zhang, J AU - Mughal, M AU - Koehler, R AU - Mattson, M AU - Harris, Z Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Brain KW - Stroke KW - Ischemia KW - Animal models KW - Ceruloplasmin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+iron-regulating+protein+ceruloplasmin+protects+brain+cells+in+a+mouse+model+of+ischemic+stroke&rft.au=Texel%2C+S%3BZhang%2C+J%3BMughal%2C+M%3BKoehler%2C+R%3BMattson%2C+M%3BHarris%2C+Z&rft.aulast=Texel&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two mnemonic processes underlie visual recognition memory in rhesus monkeys T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194274; 5576380 JF - 39th Annual meeting of the Society for Neuroscience AU - Guderian, S AU - Brigham, D AU - Turchi, J AU - Saunders, R AU - Mishkin, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Memory KW - Visual perception KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Two+mnemonic+processes+underlie+visual+recognition+memory+in+rhesus+monkeys&rft.au=Guderian%2C+S%3BBrigham%2C+D%3BTurchi%2C+J%3BSaunders%2C+R%3BMishkin%2C+M&rft.aulast=Guderian&rft.aufirst=S&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electroconvulsive shock increases neuronal stress resistance, lessens motor deficits and extends survival in Huntingtin mutant mice. T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194251; 5576976 JF - 39th Annual meeting of the Society for Neuroscience AU - Mughal, M AU - Chigurapati, S AU - Chen, E AU - Son, T AU - Griffioen, K AU - Okun, E AU - Chan, S AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Stress KW - Mice KW - Survival KW - Mutants KW - Huntingtin KW - ECS KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Electroconvulsive+shock+increases+neuronal+stress+resistance%2C+lessens+motor+deficits+and+extends+survival+in+Huntingtin+mutant+mice.&rft.au=Mughal%2C+M%3BChigurapati%2C+S%3BChen%2C+E%3BSon%2C+T%3BGriffioen%2C+K%3BOkun%2C+E%3BChan%2C+S%3BMattson%2C+M&rft.aulast=Mughal&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural circuitry of implicit emotional face processing in youth with bipolar disorderversus healthy controls T2 - 39th Annual meeting of the Society for Neuroscience AN - 42194222; 5578404 JF - 39th Annual meeting of the Society for Neuroscience AU - Thomas, L A AU - Bones, B AU - Pine, D S AU - Leibenluft, E Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Pattern recognition KW - Face KW - Emotions KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42194222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+circuitry+of+implicit+emotional+face+processing+in+youth+with+bipolar+disorderversus+healthy+controls&rft.au=Thomas%2C+L+A%3BBones%2C+B%3BPine%2C+D+S%3BLeibenluft%2C+E&rft.aulast=Thomas&rft.aufirst=L&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ln-vivo effects of bromocriptine on dopamine d2 receptor availability in the striatum in rats prone or resistant to diet-induced obesity T2 - 39th Annual meeting of the Society for Neuroscience AN - 42192866; 5576140 JF - 39th Annual meeting of the Society for Neuroscience AU - Thanos, P AU - Cho, J AU - Kim, R AU - Michaelides, M AU - Primeaux, S AU - Bray, G AU - Wang, G AU - Volkow, N Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Obesity KW - Rats KW - Bromocriptine KW - Neostriatum KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42192866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=ln-vivo+effects+of+bromocriptine+on+dopamine+d2+receptor+availability+in+the+striatum+in+rats+prone+or+resistant+to+diet-induced+obesity&rft.au=Thanos%2C+P%3BCho%2C+J%3BKim%2C+R%3BMichaelides%2C+M%3BPrimeaux%2C+S%3BBray%2C+G%3BWang%2C+G%3BVolkow%2C+N&rft.aulast=Thanos&rft.aufirst=P&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations of an kyrin-3expression in postmortem brain of patients with affective disorder T2 - 39th Annual meeting of the Society for Neuroscience AN - 42192333; 5580714 JF - 39th Annual meeting of the Society for Neuroscience AU - Yuan, P AU - Austin, D AU - Zhou, R AU - Wang, Y AU - Innis, R AU - Manji, H AU - Chen, G AU - Guitart, X Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Brain KW - Affective disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42192333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Alterations+of+an+kyrin-3expression+in+postmortem+brain+of+patients+with+affective+disorder&rft.au=Yuan%2C+P%3BAustin%2C+D%3BZhou%2C+R%3BWang%2C+Y%3BInnis%2C+R%3BManji%2C+H%3BChen%2C+G%3BGuitart%2C+X&rft.aulast=Yuan&rft.aufirst=P&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SUMO modification and Huntingtin T2 - 39th Annual meeting of the Society for Neuroscience AN - 42192024; 5576840 JF - 39th Annual meeting of the Society for Neuroscience AU - Thompson, L AU - Gire O'Rourke, J AU - Steffan, J AU - Kaltenbach, L AU - Illes, K AU - Pallos, J AU - Reverter, D AU - Mukhopadhyay, D AU - Wanker, E AU - Dasso, M AU - Lo, D. AU - Lima, C AU - Marsh, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Huntingtin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42192024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=SUMO+modification+and+Huntingtin&rft.au=Thompson%2C+L%3BGire+O%27Rourke%2C+J%3BSteffan%2C+J%3BKaltenbach%2C+L%3BIlles%2C+K%3BPallos%2C+J%3BReverter%2C+D%3BMukhopadhyay%2C+D%3BWanker%2C+E%3BDasso%2C+M%3BLo%2C+D.%3BLima%2C+C%3BMarsh%2C+J&rft.aulast=Thompson&rft.aufirst=L&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/skins/main/pdf/final_program/final_program_b 4.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: Roles of HDAC and MMP-9 inhibition T2 - 39th Annual meeting of the Society for Neuroscience AN - 42191822; 5578846 JF - 39th Annual meeting of the Society for Neuroscience AU - Wang, Z AU - Leng, Y AU - Leeds, P AU - Chuang, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Ischemia KW - Valproic acid KW - Histone deacetylase KW - Blood-brain barrier KW - Gelatinase B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42191822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Valproic+acid+attenuates+blood-brain+barrier+disruption+in+a+rat+model+of+transient+focal+cerebral+ischemia%3A+Roles+of+HDAC+and+MMP-9+inhibition&rft.au=Wang%2C+Z%3BLeng%2C+Y%3BLeeds%2C+P%3BChuang%2C+D&rft.aulast=Wang&rft.aufirst=Z&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bid inhibitors: A potential novel- antidepressant treatment T2 - 39th Annual meeting of the Society for Neuroscience AN - 42191119; 5580724 JF - 39th Annual meeting of the Society for Neuroscience AU - Malkesman, O AU - Tragon, T AU - Austin, D AU - Reed, J AU - Pellecchia, M AU - Chen, G AU - Manji, H Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Antidepressants KW - BID protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42191119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Bid+inhibitors%3A+A+potential+novel-+antidepressant+treatment&rft.au=Malkesman%2C+O%3BTragon%2C+T%3BAustin%2C+D%3BReed%2C+J%3BPellecchia%2C+M%3BChen%2C+G%3BManji%2C+H&rft.aulast=Malkesman&rft.aufirst=O&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hydrocortisone administration selectively enhances anterior cingulate activation during viewing of sad facial expressions T2 - 39th Annual meeting of the Society for Neuroscience AN - 42190303; 5574843 JF - 39th Annual meeting of the Society for Neuroscience AU - Drevets, W AU - Erickson, K AU - Schulkin, J AU - Nugent, A AU - Fromm, S AU - Tully, J AU - Furey, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Hydrocortisone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42190303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Hydrocortisone+administration+selectively+enhances+anterior+cingulate+activation+during+viewing+of+sad+facial+expressions&rft.au=Drevets%2C+W%3BErickson%2C+K%3BSchulkin%2C+J%3BNugent%2C+A%3BFromm%2C+S%3BTully%2C+J%3BFurey%2C+M&rft.aulast=Drevets&rft.aufirst=W&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High trait psychopathy is associated with reduced orbital frontal, ventral striatal, and cingulate activity in a risky decision making task T2 - 39th Annual meeting of the Society for Neuroscience AN - 42189384; 5576282 JF - 39th Annual meeting of the Society for Neuroscience AU - Sutherland, M AU - Flannery, B AU - Matochik, J AU - Fishbein, D Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Personality KW - Neostriatum KW - Decision making KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42189384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=High+trait+psychopathy+is+associated+with+reduced+orbital+frontal%2C+ventral+striatal%2C+and+cingulate+activity+in+a+risky+decision+making+task&rft.au=Sutherland%2C+M%3BFlannery%2C+B%3BMatochik%2C+J%3BFishbein%2C+D&rft.aulast=Sutherland&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Emotional processing biases during selective attention in visual processing areas in healthy and patients with depression T2 - 39th Annual meeting of the Society for Neuroscience AN - 42189219; 5576215 JF - 39th Annual meeting of the Society for Neuroscience AU - Furey, M AU - Hoffman, E AU - Drevets, W Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Depression KW - Attention KW - Visual perception KW - Emotions KW - Information processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42189219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Emotional+processing+biases+during+selective+attention+in+visual+processing+areas+in+healthy+and+patients+with+depression&rft.au=Furey%2C+M%3BHoffman%2C+E%3BDrevets%2C+W&rft.aulast=Furey&rft.aufirst=M&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural dynamics in the contextual association network T2 - 39th Annual meeting of the Society for Neuroscience AN - 42188995; 5577067 JF - 39th Annual meeting of the Society for Neuroscience AU - Kveraga, K AU - Kassam, K AU - Aminoff, E AU - Hamalalnen, M AU - Ghuman, A AU - Chaumon, M AU - Bar, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42188995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+dynamics+in+the+contextual+association+network&rft.au=Kveraga%2C+K%3BKassam%2C+K%3BAminoff%2C+E%3BHamalalnen%2C+M%3BGhuman%2C+A%3BChaumon%2C+M%3BBar%2C+M&rft.aulast=Kveraga&rft.aufirst=K&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Corticostriatal mediation of over-learning and cognitive flexibility in a mouse touchscreen apparatus T2 - 39th Annual meeting of the Society for Neuroscience AN - 42188774; 5578896 JF - 39th Annual meeting of the Society for Neuroscience AU - Brigman, J AU - Graybeal, C AU - Wright, T AU - Saksida, L AU - Bussey, T AU - Jinde, S AU - Davis, M AU - Nakazawa, K AU - Delpire, E AU - Lovinger, D AU - Holmes, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Cortex KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42188774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Corticostriatal+mediation+of+over-learning+and+cognitive+flexibility+in+a+mouse+touchscreen+apparatus&rft.au=Brigman%2C+J%3BGraybeal%2C+C%3BWright%2C+T%3BSaksida%2C+L%3BBussey%2C+T%3BJinde%2C+S%3BDavis%2C+M%3BNakazawa%2C+K%3BDelpire%2C+E%3BLovinger%2C+D%3BHolmes%2C+A&rft.aulast=Brigman&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reciprocal interactions between respiration and lumbar rhythmic activity in a perfused preparation ofthe mouse spinal cord T2 - 39th Annual meeting of the Society for Neuroscience AN - 42188764; 5577009 JF - 39th Annual meeting of the Society for Neuroscience AU - Yazawa, I AU - O'donovan, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Respiration KW - Spinal cord KW - Rhythms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42188764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Reciprocal+interactions+between+respiration+and+lumbar+rhythmic+activity+in+a+perfused+preparation+ofthe+mouse+spinal+cord&rft.au=Yazawa%2C+I%3BO%27donovan%2C+M&rft.aulast=Yazawa&rft.aufirst=I&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral effects of the high-affinity serotonin 5-HT2A receptor agonist TCB-2 T2 - 39th Annual meeting of the Society for Neuroscience AN - 42188405; 5579205 JF - 39th Annual meeting of the Society for Neuroscience AU - Laporte, J AU - Blackler, A AU - French, H AU - Murphy, D AU - Fox, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Serotonin S2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42188405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+effects+of+the+high-affinity+serotonin+5-HT2A+receptor+agonist+TCB-2&rft.au=Laporte%2C+J%3BBlackler%2C+A%3BFrench%2C+H%3BMurphy%2C+D%3BFox%2C+M&rft.aulast=Laporte&rft.aufirst=J&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of vasopressin on mPFC- amygdala circuitry during fearful face processing in humans T2 - 39th Annual meeting of the Society for Neuroscience AN - 42187562; 5576227 JF - 39th Annual meeting of the Society for Neuroscience AU - Zink, C AU - Kempf, L AU - Stein, J AU - Hakimi, S AU - Meyer-Lindenberg, A Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Pattern recognition KW - Face KW - Amygdala KW - Vasopressin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42187562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+vasopressin+on+mPFC-+amygdala+circuitry+during+fearful+face+processing+in+humans&rft.au=Zink%2C+C%3BKempf%2C+L%3BStein%2C+J%3BHakimi%2C+S%3BMeyer-Lindenberg%2C+A&rft.aulast=Zink&rft.aufirst=C&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A non-telomeric role for a truncated isoform of trf2 in the regulation of dendritic growth via a golgi apparatus-dependent mechanism T2 - 39th Annual meeting of the Society for Neuroscience AN - 42186711; 5578074 JF - 39th Annual meeting of the Society for Neuroscience AU - Zhang, P AU - Jiang, H AU - Mughal, M AU - Gleichmann, M AU - Mattson, M Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - TRF2 protein KW - Golgi apparatus KW - Telomere-binding protein KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42186711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=A+non-telomeric+role+for+a+truncated+isoform+of+trf2+in+the+regulation+of+dendritic+growth+via+a+golgi+apparatus-dependent+mechanism&rft.au=Zhang%2C+P%3BJiang%2C+H%3BMughal%2C+M%3BGleichmann%2C+M%3BMattson%2C+M&rft.aulast=Zhang&rft.aufirst=P&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axon T2 - 39th Annual meeting of the Society for Neuroscience AN - 42186672; 5577759 JF - 39th Annual meeting of the Society for Neuroscience AU - Chen, Y AU - Gerwin, C AU - Sheng, Z Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Dynein KW - Mitochondria KW - Light chains KW - Axons KW - Berthing KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42186672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynein+light+chain+LC8+regulates+syntaphilin-mediated+mitochondrial+docking+in+axon&rft.au=Chen%2C+Y%3BGerwin%2C+C%3BSheng%2C+Z&rft.aulast=Chen&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dendritic Integration in A17 Amacrine Cells: Tens of Microcircuits within a Single Retinal Interneuron. T2 - 39th Annual meeting of the Society for Neuroscience AN - 42185540; 5575200 JF - 39th Annual meeting of the Society for Neuroscience AU - Grimes, W AU - Diamond, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Circuits KW - Retina KW - Integration KW - Interneurons KW - Amacrine cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42185540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Dendritic+Integration+in+A17+Amacrine+Cells%3A+Tens+of+Microcircuits+within+a+Single+Retinal+Interneuron.&rft.au=Grimes%2C+W%3BDiamond%2C+J&rft.aulast=Grimes&rft.aufirst=W&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Functional Characterization of a Novel Acetylcholine-Binding Protein from the Marine Annelid Capitella Capitata. T2 - 39th Annual meeting of the Society for Neuroscience AN - 42184994; 5575120 JF - 39th Annual meeting of the Society for Neuroscience AU - Mccormack, T AU - Petrovich, R AU - Mercier, K AU - Derose, E AU - Cuneo, M AU - Williams, J AU - London, R AU - Yakel, J Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Acetylcholine-binding protein KW - Capitella capitata KW - Annelida KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42184994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+and+Functional+Characterization+of+a+Novel+Acetylcholine-Binding+Protein+from+the+Marine+Annelid+Capitella+Capitata.&rft.au=Mccormack%2C+T%3BPetrovich%2C+R%3BMercier%2C+K%3BDerose%2C+E%3BCuneo%2C+M%3BWilliams%2C+J%3BLondon%2C+R%3BYakel%2C+J&rft.aulast=Mccormack&rft.aufirst=T&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Future of NIH: Advancing Biomedical Research to Benefit Humankind T2 - 39th Annual meeting of the Society for Neuroscience AN - 42184993; 5576526 JF - 39th Annual meeting of the Society for Neuroscience AU - Collins, Francis Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42184993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Future+of+NIH%3A+Advancing+Biomedical+Research+to+Benefit+Humankind&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glia-derived tumor necrosis factor-a promotes AMPA-containing synaptogenesis in the CNS T2 - 39th Annual meeting of the Society for Neuroscience AN - 42181663; 5577563 JF - 39th Annual meeting of the Society for Neuroscience AU - Wang, Y AU - Khairova, R AU - Wei, Y AU - Machado-Vieira, R AU - Tao, Y AU - Du, J. AU - Manji, H Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - Tumors KW - Tumor necrosis factor-a KW - Central nervous system KW - Synaptogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42181663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Glia-derived+tumor+necrosis+factor-a+promotes+AMPA-containing+synaptogenesis+in+the+CNS&rft.au=Wang%2C+Y%3BKhairova%2C+R%3BWei%2C+Y%3BMachado-Vieira%2C+R%3BTao%2C+Y%3BDu%2C+J.%3BManji%2C+H&rft.aulast=Wang&rft.aufirst=Y&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Monitoring of Movement T2 - 39th Annual meeting of the Society for Neuroscience AN - 42181395; 5576527 JF - 39th Annual meeting of the Society for Neuroscience AU - Wurtz, Robert Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42181395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=Mental+Monitoring+of+Movement&rft.au=Wurtz%2C+Robert&rft.aulast=Wurtz&rft.aufirst=Robert&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The properties of global signal regression on resting state networks T2 - 39th Annual meeting of the Society for Neuroscience AN - 42179388; 5576659 JF - 39th Annual meeting of the Society for Neuroscience AU - Handwerker, D AU - Birn, R AU - Murphy, K AU - Bandettini, P Y1 - 2009/10/17/ PY - 2009 DA - 2009 Oct 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42179388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.atitle=The+properties+of+global+signal+regression+on+resting+state+networks&rft.au=Handwerker%2C+D%3BBirn%2C+R%3BMurphy%2C+K%3BBandettini%2C+P&rft.aulast=Handwerker&rft.aufirst=D&rft.date=2009-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2009/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The History of the IIM T2 - 2009 Philadelphia Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 42457624; 5424194 JF - 2009 Philadelphia Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Plotz, Paul Y1 - 2009/10/16/ PY - 2009 DA - 2009 Oct 16 KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42457624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Philadelphia+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+History+of+the+IIM&rft.au=Plotz%2C+Paul&rft.aulast=Plotz&rft.aufirst=Paul&rft.date=2009-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Philadelphia+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://acr.confex.com/acr/2009/webprogramsyllabus/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Literacy: Important Factor to Consider When Surfing the Web for Reliable Health Information for Your Patients T2 - 2009 Philadelphia Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 42457496; 5424161 JF - 2009 Philadelphia Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Austin, Janet AU - Kunkel, Ann Y1 - 2009/10/16/ PY - 2009 DA - 2009 Oct 16 KW - Surfing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42457496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Philadelphia+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Health+Literacy%3A+Important+Factor+to+Consider+When+Surfing+the+Web+for+Reliable+Health+Information+for+Your+Patients&rft.au=Austin%2C+Janet%3BKunkel%2C+Ann&rft.aulast=Austin&rft.aufirst=Janet&rft.date=2009-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Philadelphia+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://acr.confex.com/acr/2009/webprogramsyllabus/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome. AN - 734089712; 19806030 AB - Despite improvements in the therapeutic efficacy of rationally designed cancer treatment regimens, most cancers remain incurable once spread beyond their sites of origin. Failure to achieve sustained control or eradication of cancers arises in large part because a subpopulation of quiescent "cancer stem cells" is insensitive to drugs targeting cell growth and replication and because defense mechanisms critical to survival of the normal cell also protect the cancer cell from cytotoxic injury. Global alteration of signal transduction by inhibition of serine/threonine dephosphorylation has recently been shown to markedly potentiate cancer cell killing by the DNA-methylating drug, temozolomide. Inhibition of the multifunctional protein phosphatase 2A appears to drive quiescent cancer cells into cycle and simultaneously inhibits cycle arrest, permitting cancer cell entry into mitosis despite the presence of chemotherapy induced DNA-damage. Absence of toxicity in animal models suggests that multi-site mutations in pathways regulating cell cycle in cancer cells make them more vulnerable than normal cells to large changes in the balance of phosphorylation-regulated signaling. Global modulation of the serine-threonine phospho-proteome may be a general method for enhancing the effectiveness of cytotoxic cancer therapy. JF - Cell cycle (Georgetown, Tex.) AU - Zhuang, Zhengping AU - Lu, Jie AU - Lonser, Russell AU - Kovach, John S AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. zhuangp@ninds.nih.gov Y1 - 2009/10/15/ PY - 2009 DA - 2009 Oct 15 SP - 3303 EP - 3306 VL - 8 IS - 20 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Proteome KW - Tumor Suppressor Protein p53 KW - Dacarbazine KW - 7GR28W0FJI KW - Protein Phosphatase 2 KW - EC 3.1.3.16 KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Animals KW - Phosphorylation KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Dacarbazine -- analogs & derivatives KW - Dacarbazine -- pharmacology KW - Mice KW - DNA Breaks, Double-Stranded KW - Tumor Suppressor Protein p53 -- metabolism KW - Signal Transduction KW - Neoplasms -- drug therapy KW - DNA Damage KW - Protein Phosphatase 2 -- antagonists & inhibitors KW - Cell Cycle KW - Protein Phosphatase 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734089712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Enhancement+of+cancer+chemotherapy+by+simultaneously+altering+cell+cycle+progression+and+DNA-damage+defenses+through+global+modification+of+the+serine%2Fthreonine+phospho-proteome.&rft.au=Zhuang%2C+Zhengping%3BLu%2C+Jie%3BLonser%2C+Russell%3BKovach%2C+John+S&rft.aulast=Zhuang&rft.aufirst=Zhengping&rft.date=2009-10-15&rft.volume=8&rft.issue=20&rft.spage=3303&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-21 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computational investigation of the oxidative deboronation of boroglycine, H2N-CH2-B(OH)2, Using H2O and H2O2. AN - 734077493; 19810757 AB - We report results from a computational investigation of the oxidative deboronation of boroglycine, H2N-CH2-B(OH)2, using H2O and H2O2 as the reactive oxygen species (ROS) to yield aminomethanol, H2N-CH2-OH; these results complement our study on the protodeboronation of boroglycine to produce methylamine, H2N-CH3 (Larkin et al. J. Phys. Chem. A 2007, 111, 6489-6500). Second-order Møller-Plesset (MP2) perturbation theory with Dunning-Woon correlation-consistent (cc) basis sets were used for the calculations with comparisons made to results from density functional theory (DFT) at the PBE1PBE/6-311++G(d,p)(cc-pVDZ) levels. The effects of a bulk aqueous environment were also incorporated into the calculations employing PCM and CPCM methodology. Using H2O as the ROS, the reaction H2O + H2N-CH2-B(OH)2 --> H2N-CH2-OH + H-B(OH)2 was calculated to be endothermic; the value of DeltaH(298)(0) was +12.0 kcal/mol at the MP2(FC)/cc-pVTZ computational level in vacuo and +13.7 kcal/mol in PCM aqueous media; the corresponding value for the activation barrier, DeltaH(double dagger), was +94.3 kcal/mol relative to the separated reactants in vacuo and +89.9 kcal/mol in PCM aqueous media. In contrast, the reaction H2O2 + H2N-CH2-B(OH)2 --> H2N-CH2-OH + B(OH)3 was calculated to be highly exothermic with an DeltaH(298)(0) value of -100.9 kcal/mol at the MP2(FC)/cc-pVTZ computational level in vacuo and -99.6 kcal/mol in CPCM aqueous media; the highest-energy transition state for the multistep process associated with this reaction involved the rearrangement of H2N-CH2-B(OH)(OOH) to H2N-CH2-O-B(OH)2 with a DeltaH(double dagger) value of +23.2 kcal/mol in vacuo relative to the separated reactants. These computational results for boroglycine are in accord with the experimental observations for the deboronation of the FDA approved anticancer drug bortezomib (Velcade, PS-341), where it was found to be the principle deactivation pathway (Labutti et al. Chem. Res. Toxicol. 2006, 19, 539-546). JF - The journal of physical chemistry. A AU - Larkin, Joseph D AU - Markham, George D AU - Milkevitch, Matt AU - Brooks, Bernard R AU - Bock, Charles W AD - The National Institutes of Health, National Heart, Lung, and Blood Institute, 5635 Fishers Lane, Rockville, Maryland 20852, USA. Y1 - 2009/10/15/ PY - 2009 DA - 2009 Oct 15 SP - 11028 EP - 11034 VL - 113 IS - 41 KW - Boron Compounds KW - 0 KW - boroglycine KW - Water KW - 059QF0KO0R KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Oxidation-Reduction KW - Molecular Structure KW - Thermodynamics KW - Glycine -- chemistry KW - Computer Simulation KW - Water -- chemistry KW - Glycine -- analogs & derivatives KW - Boron Compounds -- chemistry KW - Hydrogen Peroxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734077493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+physical+chemistry.+A&rft.atitle=Computational+investigation+of+the+oxidative+deboronation+of+boroglycine%2C+H2N-CH2-B%28OH%292%2C+Using+H2O+and+H2O2.&rft.au=Larkin%2C+Joseph+D%3BMarkham%2C+George+D%3BMilkevitch%2C+Matt%3BBrooks%2C+Bernard+R%3BBock%2C+Charles+W&rft.aulast=Larkin&rft.aufirst=Joseph&rft.date=2009-10-15&rft.volume=113&rft.issue=41&rft.spage=11028&rft.isbn=&rft.btitle=&rft.title=The+journal+of+physical+chemistry.+A&rft.issn=1520-5215&rft_id=info:doi/10.1021%2Fjp904149w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioconjug Chem. 2001 Mar-Apr;12(2):229-39 [11312684] Drug Metab Dispos. 2005 Jun;33(6):771-7 [15764713] J Am Chem Soc. 2001 Jun 27;123(25):6092-7 [11414843] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13058-63 [16141327] Cancer Res. 2005 Dec 15;65(24):11658-66 [16357177] J Phys Chem A. 2005 Dec 29;109(51):12014-9 [16366656] Bioorg Med Chem Lett. 2006 Apr 1;16(7):1788-94 [16458505] Cancer Res. 2006 Apr 1;66(7):3773-81 [16585204] Chem Res Toxicol. 2006 Apr;19(4):539-46 [16608165] J Phys Chem A. 2006 Sep 14;110(36):10633-42 [16956246] J Phys Chem A. 2007 Jul 19;111(28):6489-500 [17595064] J Phys Chem A. 2008 Jan 10;112(1):125-33 [18072757] Bioorg Med Chem Lett. 2002 Sep 16;12(18):2553-6 [12182858] J Am Chem Soc. 2003 Mar 26;125(12):3493-502 [12643711] Med Res Rev. 2003 May;23(3):346-68 [12647314] J Surg Res. 2003 Jul;113(1):88-95 [12943815] Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):267-77 [14697448] J Am Chem Soc. 2004 Mar 31;126(12):3714-5 [15038715] J Org Chem. 2004 Mar 19;69(6):1999-2007 [15058946] Cancer Invest. 2004;22(2):304-11 [15199612] J Am Chem Soc. 1977 Sep 14;99(19):6435-7 [893893] Arch Biochem Biophys. 1984 Nov 1;234(2):531-6 [6548619] Biochemistry. 1989 Apr 18;28(8):3541-9 [2663072] Clin Chim Acta. 1997 Jul 25;263(2):207-24 [9246425] J Biol Chem. 1997 Oct 17;272(42):26103-9 [9334174] Bioorg Med Chem Lett. 1998 Feb 17;8(4):333-8 [9871680] Mini Rev Med Chem. 2004 Nov;4(9):1001-18 [15544560] J Fluoresc. 2004 Sep;14(5):549-59 [15617262] J Am Chem Soc. 2005 Apr 20;127(15):5423-34 [15826180] Org Lett. 2001 May 17;3(10):1487-90 [11388848] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jp904149w ER - TY - JOUR T1 - Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. AN - 67684730; 19661246 AB - In humans, immune responses to inhaled aeroallergens develop in the lung and draining lymph nodes. Many animal models of asthma bypass this route and instead use intraperitoneal injections of allergen using aluminum hydroxide as an adjuvant. We investigated whether allergic sensitization through the airway elicits immune responses qualitatively different than those arising in the peritoneum. Mice were sensitized to allergen through the airway using low-dose LPS as an adjuvant, or through the peritoneum using aluminum hydroxide as an adjuvant. After a single allergen challenge, ELISA and flow cytometry were used to measure cytokines and leukocyte subsets. Invasive measurements of airway resistance were used to measure allergen-induced airway hyperreactivity (AHR). Sensitization through the peritoneum primed strong Th2 responses and eosinophilia, but not AHR, after a single allergen challenge. By contrast, allergic sensitization through the airway primed only modest Th2 responses, but strong Th17 responses. Th17 cells homed to the lung and released IL-17 into the airway on subsequent encounter with inhaled allergen. As a result, these mice developed IL-17-dependent airway neutrophilia and AHR. This AHR was neutrophil-dependent because it was abrogated in CXCR2-deficient mice and also in wild-type mice receiving a neutrophil-depleting antibody. Individually, neither IL-17 nor ongoing Th2 responses were sufficient to confer AHR, but together they acted synergistically to promote neutrophil recruitment, eosinophil recruitment and AHR. Allergic sensitization through the airway primes modest Th2 responses but strong Th17 responses that promote airway neutrophilia and acute AHR. These findings support a causal role for neutrophils in severe asthma. JF - American journal of respiratory and critical care medicine AU - Wilson, Rhonda H AU - Whitehead, Gregory S AU - Nakano, Hideki AU - Free, Meghan E AU - Kolls, Jay K AU - Cook, Donald N AD - Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/10/15/ PY - 2009 DA - 2009 Oct 15 SP - 720 EP - 730 VL - 180 IS - 8 KW - Interleukin-17 KW - 0 KW - Lipopolysaccharides KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Leukocytosis KW - Lipopolysaccharides -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Immunization KW - Mice, Knockout KW - Bronchial Hyperreactivity -- immunology KW - Bronchial Hyperreactivity -- chemically induced KW - Neutrophils -- immunology KW - T-Lymphocyte Subsets -- immunology KW - Bronchial Hyperreactivity -- physiopathology KW - Interleukin-17 -- immunology KW - Disease Models, Animal KW - Asthma -- chemically induced KW - Asthma -- physiopathology KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67684730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Allergic+sensitization+through+the+airway+primes+Th17-dependent+neutrophilia+and+airway+hyperresponsiveness.&rft.au=Wilson%2C+Rhonda+H%3BWhitehead%2C+Gregory+S%3BNakano%2C+Hideki%3BFree%2C+Meghan+E%3BKolls%2C+Jay+K%3BCook%2C+Donald+N&rft.aulast=Wilson&rft.aufirst=Rhonda&rft.date=2009-10-15&rft.volume=180&rft.issue=8&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/10.1164%2Frccm.200904-0573OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Dec 15;163(12):6448-54 [10586035] Am J Respir Crit Care Med. 2009 Mar 1;179(5):344-55 [19096007] J Exp Med. 2001 Aug 20;194(4):519-27 [11514607] J Allergy Clin Immunol. 2001 Sep;108(3):430-8 [11544464] Eur Respir J. 2002 Jan;19(1):76-83 [11843330] J Exp Med. 2002 Dec 16;196(12):1645-51 [12486107] J Allergy Clin Immunol. 2003 Mar;111(3):450-63; quiz 464 [12642820] Respir Res. 2003;4:3 [12657158] Nat Rev Immunol. 2003 May;3(5):405-12 [12766762] Am J Respir Cell Mol Biol. 2004 Jun;30(6):837-43 [14742296] Am J Respir Cell Mol Biol. 1994 Feb;10(2):148-53 [8110470] Int Arch Allergy Immunol. 1994 Sep;105(1):83-90 [8086833] Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):737-43 [9309987] Am J Respir Crit Care Med. 1998 Jan;157(1):4-9 [9445270] J Exp Med. 1998 Mar 16;187(6):939-48 [9500796] J Exp Med. 1998 May 4;187(9):1537-42 [9565645] J Immunol. 1999 Feb 15;162(4):2347-52 [9973514] J Clin Invest. 2005 Feb;115(2):459-67 [15650773] Nat Immunol. 2005 Nov;6(11):1133-41 [16200068] Nat Immunol. 2005 Nov;6(11):1123-32 [16200070] J Immunol. 2006 May 15;176(10):5856-62 [16670292] J Immunol. 2006 Jul 1;177(1):36-9 [16785495] Immunol Res. 2006;34(3):229-42 [16891673] Am J Respir Crit Care Med. 2006 Dec 15;174(12):1286-91 [16973985] Am J Respir Crit Care Med. 2007 Feb 1;175(3):243-9 [17095748] J Allergy Clin Immunol. 2007 May;119(5):1055-62; quiz 1063-4 [17353033] J Allergy Clin Immunol. 2007 May;119(5):1282-6 [17412406] J Exp Med. 2007 May 14;204(5):995-1001 [17470641] Immunity. 2008 Apr;28(4):454-67 [18400188] J Exp Med. 2008 Apr 14;205(4):869-82 [18362170] J Exp Med. 2008 May 12;205(5):1063-75 [18411338] J Immunol. 2008 Nov 1;181(9):6117-24 [18941201] Curr Opin Pulm Med. 2009 Jan;15(1):63-71 [19077708] Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):721-30 [11254531] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1164/rccm.200904-0573OC ER - TY - JOUR T1 - Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies AN - 21222504; 11223690 AB - Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years) and its modification by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls. Above 15 cigarettes/day, the EOR/pack-year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration. Estimates of EOR/pack-year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack-years. EOR/drink-year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited. EOR/drink-year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink-years and not drinks/day. JF - American Journal of Epidemiology AU - Lubin, Jay H AU - Purdue, Mark AU - Kelsey, Karl AU - Zhang, Zuo-Feng AU - Winn, Debbie AU - Wei, Qingyi AU - Talamini, Renato AU - Szeszenia-Dabrowska, Neonilia AU - Sturgis, Erich M AU - Smith, Elaine AU - Shangina, Oxana AU - Schwartz, Stephen M AU - Rudnai, Peter AU - Neto, Jose Eluf AU - Muscat, Joshua AU - Morgenstern, Hal AU - Menezes, Ana AU - Matos, Elena AU - Mates, Ioan Nicolae AU - Lissowska, Jolanta AU - Levi, Fabio AU - Lazarus, Philip AU - Vecchia, Carlo La AU - Koifman, Sergio AU - Herrero, Rolando AU - Franceschi, Silvia AU - Wuensch-Filho, Victor AU - Fernandez, Leticia AU - Fabianova, Eleonora AU - Daudt, Alexander W AU - Maso, Luigino Dal AU - Curado, Maria Paula AU - Chen, Chu AU - Castellsague, Xavier AU - Brennan, Paul AU - Boffetta, Paolo AU - Hashibe, Mia AU - Hayes, Richard B Y1 - 2009/10/15/ PY - 2009 DA - 2009 Oct 15 SP - 937 EP - 947 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 170 IS - 8 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Toxicology Abstracts KW - Alcohol KW - Cavities KW - Laryngeal cancer KW - Beverages KW - Pharynx KW - Data processing KW - Cancer KW - Oral cavity KW - Models KW - Cigarette smoking KW - Head and neck cancer KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21222504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Total+Exposure+and+Exposure+Rate+Effects+for+Alcohol+and+Smoking+and+Risk+of+Head+and+Neck+Cancer%3A+A+Pooled+Analysis+of+Case-Control+Studies&rft.au=Lubin%2C+Jay+H%3BPurdue%2C+Mark%3BKelsey%2C+Karl%3BZhang%2C+Zuo-Feng%3BWinn%2C+Debbie%3BWei%2C+Qingyi%3BTalamini%2C+Renato%3BSzeszenia-Dabrowska%2C+Neonilia%3BSturgis%2C+Erich+M%3BSmith%2C+Elaine%3BShangina%2C+Oxana%3BSchwartz%2C+Stephen+M%3BRudnai%2C+Peter%3BNeto%2C+Jose+Eluf%3BMuscat%2C+Joshua%3BMorgenstern%2C+Hal%3BMenezes%2C+Ana%3BMatos%2C+Elena%3BMates%2C+Ioan+Nicolae%3BLissowska%2C+Jolanta%3BLevi%2C+Fabio%3BLazarus%2C+Philip%3BVecchia%2C+Carlo+La%3BKoifman%2C+Sergio%3BHerrero%2C+Rolando%3BFranceschi%2C+Silvia%3BWuensch-Filho%2C+Victor%3BFernandez%2C+Leticia%3BFabianova%2C+Eleonora%3BDaudt%2C+Alexander+W%3BMaso%2C+Luigino+Dal%3BCurado%2C+Maria+Paula%3BChen%2C+Chu%3BCastellsague%2C+Xavier%3BBrennan%2C+Paul%3BBoffetta%2C+Paolo%3BHashibe%2C+Mia%3BHayes%2C+Richard+B&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2009-10-15&rft.volume=170&rft.issue=8&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Cavities; Laryngeal cancer; Data processing; Pharynx; Beverages; Cigarette smoking; Head and neck cancer; Oral cavity; Models; Ethanol; Alcohol; Cancer DO - http://dx.doi.org/10.1093/aje/kwp222 ER - TY - CPAPER T1 - NCI's Clinical Proteomic Technologies Initiative: A Strategic Plan for Translating Proteomic Technologies and Discoveries from the Laboratory to the Clinic T2 - 5th Modern Drug Discovery And Development Summit (M3D 2009) AN - 42486555; 5440248 JF - 5th Modern Drug Discovery And Development Summit (M3D 2009) AU - Rodriguez, Henry Y1 - 2009/10/14/ PY - 2009 DA - 2009 Oct 14 KW - Technology KW - Proteomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42486555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Modern+Drug+Discovery+And+Development+Summit+%28M3D+2009%29&rft.atitle=NCI%27s+Clinical+Proteomic+Technologies+Initiative%3A+A+Strategic+Plan+for+Translating+Proteomic+Technologies+and+Discoveries+from+the+Laboratory+to+the+Clinic&rft.au=Rodriguez%2C+Henry&rft.aulast=Rodriguez&rft.aufirst=Henry&rft.date=2009-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Modern+Drug+Discovery+And+Development+Summit+%28M3D+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/M3D_2008.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray-directed gene discovery for neuropeptide signaling in stress T2 - 19th Neuropharmacology Conference (Neuropeptides 2009) AN - 42459086; 5426494 JF - 19th Neuropharmacology Conference (Neuropeptides 2009) AU - Stroth, N AU - Holighaus, Y AU - Ait-Ali, D AU - Eiden, L E AU - Vaudry, D AU - Ravni, A Y1 - 2009/10/14/ PY - 2009 DA - 2009 Oct 14 KW - Stress KW - Signal transduction KW - DNA microarrays KW - Neuropeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Neuropharmacology+Conference+%28Neuropeptides+2009%29&rft.atitle=Microarray-directed+gene+discovery+for+neuropeptide+signaling+in+stress&rft.au=Stroth%2C+N%3BHolighaus%2C+Y%3BAit-Ali%2C+D%3BEiden%2C+L+E%3BVaudry%2C+D%3BRavni%2C+A&rft.aulast=Stroth&rft.aufirst=N&rft.date=2009-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Neuropharmacology+Conference+%28Neuropeptides+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.neuropharmacology-conference.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tracking Fluorescence Correlation Spectroscopy of Individual Biomolecules T2 - 2009 Joint 93rd OSA Annual Meeting Frontiers in Optics And Laser Science XXV (FiO 2009/LS XXV) AN - 42477836; 5429664 JF - 2009 Joint 93rd OSA Annual Meeting Frontiers in Optics And Laser Science XXV (FiO 2009/LS XXV) AU - McHale, Kevin AU - Berglund, Andrew AU - Zhang, Ke AU - Limouse, Charles AU - Raman, Chandra AU - Mabuchi, Hideo Y1 - 2009/10/11/ PY - 2009 DA - 2009 Oct 11 KW - Spectroscopy KW - Fluorescence KW - Fluorescence spectroscopy KW - Tracking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42477836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Joint+93rd+OSA+Annual+Meeting+Frontiers+in+Optics+And+Laser+Science+XXV+%28FiO+2009%2FLS+XXV%29&rft.atitle=Tracking+Fluorescence+Correlation+Spectroscopy+of+Individual+Biomolecules&rft.au=McHale%2C+Kevin%3BBerglund%2C+Andrew%3BZhang%2C+Ke%3BLimouse%2C+Charles%3BRaman%2C+Chandra%3BMabuchi%2C+Hideo&rft.aulast=McHale&rft.aufirst=Kevin&rft.date=2009-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Joint+93rd+OSA+Annual+Meeting+Frontiers+in+Optics+And+Laser+Science+XXV+%28FiO+2009%2FLS+XXV%29&rft.issn=&rft_id=info:doi/ L2 - http://www.frontiersinoptics.com/ConferenceProgram/default.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. AN - 67674465; 19695655 AB - Previously we reported a broadly HIV-1 neutralizing mini-antibody (Fab 3674) of modest potency that was derived from a human non-immune phage library by panning against the chimeric gp41-derived construct N(CCG)-gp41. This construct presents the N-heptad repeat of the gp41 ectodomain as a stable, helical, disulfide-linked trimer that extends in helical phase from the six-helix bundle of gp41. In this paper, Fab 3674 was subjected to affinity maturation against the N(CCG)-gp41 antigen by targeted diversification of the CDR-H2 loop to generate a panel of Fabs with diverse neutralization activity. Three affinity-matured Fabs selected for further study, Fabs 8060, 8066 and 8068, showed significant increases in both potency and breadth of neutralization against HIV-1 pseudotyped with envelopes of primary isolates from the standard subtype B and C HIV-1 reference panels. The parental Fab 3674 is 10-20-fold less potent in monovalent than bivalent format over the entire B and C panels of HIV-1 pseudotypes. Of note is that the improved neutralization activity of the affinity-matured Fabs relative to the parental Fab 3674 was, on average, significantly greater for the Fabs in monovalent than bivalent format. This suggests that the increased avidity of the Fabs for the target antigen in bivalent format can be partially offset by kinetic and/or steric advantages afforded by the smaller monovalent Fabs. Indeed, the best affinity-matured Fab (8066) in monovalent format ( approximately 50 kDa) was comparable in HIV-1 neutralization potency to the parental Fab 3674 in bivalent format ( approximately 120 kDa) across the subtype B and C reference panels. JF - Virology AU - Gustchina, Elena AU - Louis, John M AU - Frisch, Christian AU - Ylera, Francisco AU - Lechner, Annette AU - Bewley, Carole A AU - Clore, G Marius AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2009/10/10/ PY - 2009 DA - 2009 Oct 10 SP - 112 EP - 119 VL - 393 IS - 1 KW - Antibodies, Monoclonal KW - 0 KW - HIV Antibodies KW - HIV Envelope Protein gp41 KW - Peptide Library KW - gp41 protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Directed Molecular Evolution KW - Sequence Alignment KW - Humans KW - Neutralization Tests KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Inhibitory Concentration 50 KW - Antibody Affinity KW - HIV-1 -- immunology KW - HIV Antibodies -- immunology KW - Antibodies, Monoclonal -- genetics KW - HIV Envelope Protein gp41 -- immunology KW - HIV Antibodies -- genetics KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67674465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Affinity+maturation+by+targeted+diversification+of+the+CDR-H2+loop+of+a+monoclonal+Fab+derived+from+a+synthetic+na%C3%AFve+human+antibody+library+and+directed+against+the+internal+trimeric+coiled-coil+of+gp41+yields+a+set+of+Fabs+with+improved+HIV-1+neutralization+potency+and+breadth.&rft.au=Gustchina%2C+Elena%3BLouis%2C+John+M%3BFrisch%2C+Christian%3BYlera%2C+Francisco%3BLechner%2C+Annette%3BBewley%2C+Carole+A%3BClore%2C+G+Marius&rft.aulast=Gustchina&rft.aufirst=Elena&rft.date=2009-10-10&rft.volume=393&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.07.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 2000 Feb 11;296(1):57-86 [10656818] J Virol. 2005 Aug;79(16):10108-25 [16051804] AIDS Res Hum Retroviruses. 2000 Dec 10;16(18):2037-41 [11153086] Science. 2001 Feb 2;291(5505):884-8 [11229405] J Biol Chem. 2001 Aug 3;276(31):29485-9 [11418583] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11187-92 [11572974] Annu Rev Biochem. 2001;70:777-810 [11395423] J Biol Chem. 2002 Apr 19;277(16):14238-45 [11859089] J Virol. 2002 Jul;76(13):6780-90 [12050391] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54 [12444251] Curr Opin Biotechnol. 2002 Dec;13(6):598-602 [12482520] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14759-64 [16203977] J Mol Biol. 2005 Nov 11;353(5):945-51 [16216270] J Virol. 2006 Feb;80(3):1414-26 [16415019] J Virol. 2006 Apr;80(7):3249-58 [16537592] Nat Struct Mol Biol. 2006 Aug;13(8):740-7 [16862157] Biol Chem. 2006 Jul;387(7):995-1003 [16913849] J Biol Chem. 2006 Sep 1;281(35):25813-21 [16803885] J Mol Biol. 2006 Dec 1;364(3):283-9 [17010381] Virology. 2007 Jun 20;363(1):79-90 [17306322] J Virol. 2007 Dec;81(23):12946-53 [17898046] J Mol Biol. 2008 Feb 29;376(4):1182-200 [18191144] Virology. 2008 Jul 20;377(1):170-83 [18499210] J Virol. 2008 Jul;82(14):6869-79 [18480433] J Virol. 2008 Oct;82(20):10032-41 [18667502] Mol Immunol. 2008 Nov;46(1):135-44 [18722015] Protein Sci. 2008 Dec;17(12):2091-100 [18802030] AIDS Res Hum Retroviruses. 2003 Feb;19(2):133-44 [12639249] J Biol Chem. 2003 May 30;278(22):20278-85 [12654905] Biochim Biophys Acta. 2003 Jul 11;1614(1):36-50 [12873764] J Biol Chem. 2003 Oct 3;278(40):38194-205 [12842902] Nat Rev Drug Discov. 2004 Mar;3(3):215-25 [15031735] Curr Pharm Des. 2004;10(15):1805-25 [15180542] Eur J Biochem. 1981 Mar 16;115(1):207-16 [7227366] Adv Enzyme Regul. 1984;22:27-55 [6382953] J Virol. 1989 Nov;63(11):4670-5 [2677400] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10537-41 [1438243] Immunol Rev. 1992 Dec;130:151-88 [1286869] Nature. 1993 Sep 9;365(6442):113 [8371754] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9770-4 [7937889] Nucleic Acids Res. 1994 Dec 25;22(25):5600-7 [7838712] J Virol. 1995 Jul;69(7):4413-22 [7769703] J Virol. 1996 Sep;70(9):6136-42 [8709238] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8 [9356444] Nat Struct Biol. 1998 Apr;5(4):276-9 [9546217] Cell. 1998 May 29;93(5):681-4 [9630213] EMBO J. 1998 Aug 17;17(16):4572-84 [9707417] J Virol. 1998 Dec;72(12):10213-7 [9811763] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15613-7 [9861018] Annu Rev Immunol. 1999;17:657-700 [10358771] Cell. 1999 Oct 1;99(1):103-15 [10520998] Anal Biochem. 2005 Apr 1;339(1):182-4 [15766727] J Biol Chem. 2005 Apr 1;280(13):12567-72 [15657041] J Virol. 2005 Aug;79(16):10103-7 [16051803] J Virol. 2000 Nov;74(21):10074-80 [11024136] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.07.019 ER - TY - CPAPER T1 - Regulatory actions of estrogen receptors on GnRH neuronal function T2 - 3rd Asia-Pacific Forum on Andrology (APFA 2009) AN - 42421490; 5399807 JF - 3rd Asia-Pacific Forum on Andrology (APFA 2009) AU - Catt, Kevin AU - Hu, Lian AU - Krsmanovic, Lazar Y1 - 2009/10/10/ PY - 2009 DA - 2009 Oct 10 KW - Estrogen receptors KW - Gonadotropin-releasing hormone KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42421490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Asia-Pacific+Forum+on+Andrology+%28APFA+2009%29&rft.atitle=Regulatory+actions+of+estrogen+receptors+on+GnRH+neuronal+function&rft.au=Catt%2C+Kevin%3BHu%2C+Lian%3BKrsmanovic%2C+Lazar&rft.aulast=Catt&rft.aufirst=Kevin&rft.date=2009-10-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Asia-Pacific+Forum+on+Andrology+%28APFA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asiaandro.com/3APFA/temp/3APFA_Proceedings.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gonadotropin-regulated testicular helicase (GRTH/DDX25): a master post-transcriptional regulator of spermatogenesis T2 - 3rd Asia-Pacific Forum on Andrology (APFA 2009) AN - 42419600; 5399781 JF - 3rd Asia-Pacific Forum on Andrology (APFA 2009) AU - Dufau, Maria AU - Tsai Morris, C. AU - Sato, H AU - Fukushima, M AU - Sheng, Y AU - Gutti, R AU - Koh, E AU - Namiki, M Y1 - 2009/10/10/ PY - 2009 DA - 2009 Oct 10 KW - DNA helicase KW - Spermatogenesis KW - Pituitary (anterior) KW - Post-transcription KW - Testes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42419600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Asia-Pacific+Forum+on+Andrology+%28APFA+2009%29&rft.atitle=Gonadotropin-regulated+testicular+helicase+%28GRTH%2FDDX25%29%3A+a+master+post-transcriptional+regulator+of+spermatogenesis&rft.au=Dufau%2C+Maria%3BTsai+Morris%2C+C.%3BSato%2C+H%3BFukushima%2C+M%3BSheng%2C+Y%3BGutti%2C+R%3BKoh%2C+E%3BNamiki%2C+M&rft.aulast=Dufau&rft.aufirst=Maria&rft.date=2009-10-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Asia-Pacific+Forum+on+Andrology+%28APFA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asiaandro.com/3APFA/temp/3APFA_Proceedings.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phonological Awareness in Japanese Speaker Part I: Developmental Changes of School Age Children T2 - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AN - 42395602; 5387316 JF - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AU - Kobayashi, T AU - Inagaki, M AU - Gotoh, T AU - Gunji, A AU - Yatabe, K AU - Kaga, M AU - Koike, T Y1 - 2009/10/09/ PY - 2009 DA - 2009 Oct 09 KW - Japan KW - Children KW - Age KW - Schools KW - Developmental stages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42395602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.atitle=Phonological+Awareness+in+Japanese+Speaker+Part+I%3A+Developmental+Changes+of+School+Age+Children&rft.au=Kobayashi%2C+T%3BInagaki%2C+M%3BGotoh%2C+T%3BGunji%2C+A%3BYatabe%2C+K%3BKaga%2C+M%3BKoike%2C+T&rft.aulast=Kobayashi&rft.aufirst=T&rft.date=2009-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/espr2009/psIPlanner.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phonological Awareness in Japanese Speaker Part III: Correlarion among Basic Reading Ability, Ran and Phonological Awaraeness Tasks in Dyslexic Children T2 - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AN - 42389455; 5387902 JF - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AU - Inagaki, M AU - Kobayashi, T AU - Gotoh, T AU - Gunji, A AU - Yatabe, K AU - Kaga, M AU - Koike, T Y1 - 2009/10/09/ PY - 2009 DA - 2009 Oct 09 KW - Japan KW - Children KW - Language KW - Dyslexia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42389455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.atitle=Phonological+Awareness+in+Japanese+Speaker+Part+III%3A+Correlarion+among+Basic+Reading+Ability%2C+Ran+and+Phonological+Awaraeness+Tasks+in+Dyslexic+Children&rft.au=Inagaki%2C+M%3BKobayashi%2C+T%3BGotoh%2C+T%3BGunji%2C+A%3BYatabe%2C+K%3BKaga%2C+M%3BKoike%2C+T&rft.aulast=Inagaki&rft.aufirst=M&rft.date=2009-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/espr2009/psIPlanner.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phonological Awareness in Japanese Speaker Part II: Comparison between Dyslexic Children and Children with Normal Reading Ability T2 - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AN - 42387166; 5387908 JF - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AU - Kaga, M AU - Kobayashi, T AU - Inagaki, M AU - Gotoh, T AU - Gunji, A AU - Yatabe, K Y1 - 2009/10/09/ PY - 2009 DA - 2009 Oct 09 KW - Japan KW - Children KW - Language KW - Dyslexia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42387166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.atitle=Phonological+Awareness+in+Japanese+Speaker+Part+II%3A+Comparison+between+Dyslexic+Children+and+Children+with+Normal+Reading+Ability&rft.au=Kaga%2C+M%3BKobayashi%2C+T%3BInagaki%2C+M%3BGotoh%2C+T%3BGunji%2C+A%3BYatabe%2C+K&rft.aulast=Kaga&rft.aufirst=M&rft.date=2009-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/espr2009/psIPlanner.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differentiated Brain Activity for Familiar and Unfamiliar Faces in 3-and 6-Month-Old Infants and Their Mothers T2 - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AN - 42378932; 5387220 JF - 50th Annual Meeting of the European Society for Pediatric Research (ESPR 2009) AU - Bornstein, M Y1 - 2009/10/09/ PY - 2009 DA - 2009 Oct 09 KW - Infants KW - Brain KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42378932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.atitle=Differentiated+Brain+Activity+for+Familiar+and+Unfamiliar+Faces+in+3-and+6-Month-Old+Infants+and+Their+Mothers&rft.au=Bornstein%2C+M&rft.aulast=Bornstein&rft.aufirst=M&rft.date=2009-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+of+the+European+Society+for+Pediatric+Research+%28ESPR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/espr2009/psIPlanner.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. AN - 733699403; 19812684 AB - Chronic obstructive pulmonary disease (COPD) has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking. The Environment And Genetics in Lung cancer Etiology (EAGLE) population-based case-control study recruited 2100 cases and 2120 controls, of whom 1934 cases and 2108 controls reported about diagnosis of chronic bronchitis, emphysema, COPD (chronic bronchitis and/or emphysema), or asthma more than 1 year before enrollment. We estimated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression. After adjustment for smoking, other previous lung diseases, and study design variables, lung cancer risk was elevated among individuals with a history of chronic bronchitis (OR = 2.0, 95% CI = 1.5-2.5), emphysema (OR = 1.9, 95% CI = 1.4-2.8), or COPD (OR = 2.5, 95% CI = 2.0-3.1). Among current smokers, association between chronic bronchitis and lung cancer was strongest among lighter smokers. Asthma was associated with a decreased risk of lung cancer in males (OR = 0.48, 95% CI = 0.30-0.78). These results suggest that the associations of personal history of chronic bronchitis, emphysema, and COPD with increased risk of lung cancer are not entirely due to smoking. Inflammatory processes may both contribute to COPD and be important for lung carcinogenesis. JF - PloS one AU - Koshiol, Jill AU - Rotunno, Melissa AU - Consonni, Dario AU - Pesatori, Angela Cecilia AU - De Matteis, Sara AU - Goldstein, Alisa M AU - Chaturvedi, Anil K AU - Wacholder, Sholom AU - Landi, Maria Teresa AU - Lubin, Jay H AU - Caporaso, Neil E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America. koshiolj@mail.nih.gov Y1 - 2009/10/08/ PY - 2009 DA - 2009 Oct 08 SP - 1 VL - 4 IS - 10 KW - Index Medicus KW - Regression Analysis KW - Emphysema -- complications KW - Odds Ratio KW - Bronchitis, Chronic -- complications KW - Humans KW - Aged KW - Asthma -- complications KW - Risk KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Female KW - Male KW - Lung Neoplasms -- complications KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- diagnosis KW - Pulmonary Disease, Chronic Obstructive -- diagnosis KW - Pulmonary Disease, Chronic Obstructive -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733699403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Chronic+obstructive+pulmonary+disease+and+altered+risk+of+lung+cancer+in+a+population-based+case-control+study.&rft.au=Koshiol%2C+Jill%3BRotunno%2C+Melissa%3BConsonni%2C+Dario%3BPesatori%2C+Angela+Cecilia%3BDe+Matteis%2C+Sara%3BGoldstein%2C+Alisa+M%3BChaturvedi%2C+Anil+K%3BWacholder%2C+Sholom%3BLandi%2C+Maria+Teresa%3BLubin%2C+Jay+H%3BCaporaso%2C+Neil+E&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2009-10-08&rft.volume=4&rft.issue=10&rft.spage=e7380&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007380 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-12 N1 - Date created - 2009-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2009 Jul 1;125(1):146-52 [19350630] J Asthma. 2008 Dec;45(10):853-61 [19085573] Int J Epidemiol. 2001 Feb;30(1):118-24 [11171871] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13784-9 [11707590] Am J Epidemiol. 2002 May 15;155(10):965-71 [11994237] Chest. 2003 Jan;123(1 Suppl):21S-49S [12527563] Cancer Causes Control. 2003 May;14(4):327-34 [12846363] Am J Epidemiol. 1985 Jul;122(1):66-74 [4014202] Am Rev Respir Dis. 1986 Sep;134(3):466-70 [3752703] Cancer Res. 1991 Sep 15;51(18):4893-7 [1654203] Lancet. 1977 Sep 10;2(8037):523-6 [95731] Monaldi Arch Chest Dis. 1994 Jun;49(3):191-6 [8087112] Am J Epidemiol. 1995 Jun 1;141(11):1023-32 [7771438] Lung Cancer. 1996 Mar;14 Suppl 1:S99-105 [8785673] Am J Epidemiol. 2005 Mar 1;161(5):412-22 [15718477] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):773-8 [15824142] Am J Epidemiol. 2005 Aug 1;162(3):212-21 [15987724] Proc Am Thorac Soc. 2005;2(2):132-40 [16113481] Am J Epidemiol. 2005 Sep 15;162(6):542-7 [16093291] Am J Epidemiol. 2006 Feb 15;163(4):394-5; author reply 395-6 [16371513] CA Cancer J Clin. 2006 Mar-Apr;56(2):69-83 [16514135] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):517-23 [16537710] Clin Chest Med. 2006 Mar;27(1):1-15, v [16543048] Am J Respir Crit Care Med. 2006 May 15;173(10):1114-21 [16484677] J Natl Cancer Inst. 2006 May 17;98(10):691-9 [16705123] Eur Respir J. 2006 Sep;28(3):523-32 [16611654] Respir Res. 2006;7:116 [16956406] Intensive Crit Care Nurs. 2006 Dec;22(6):329-37 [16901700] J Clin Oncol. 2007 Feb 10;25(5):561-70 [17290066] Curr Opin Pharmacol. 2007 Jun;7(3):259-65 [17475555] Int J Epidemiol. 2007 Feb;36(1):236-41 [17510079] Int J Tuberc Lung Dis. 2007 Jun;11(6):695-702 [17519104] Am J Respir Crit Care Med. 2007 Aug 1;176(3):285-90 [17478615] Am J Respir Crit Care Med. 2007 Sep 15;176(6):532-55 [17507545] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] Int J Chron Obstruct Pulmon Dis. 2006;1(1):3-14 [18046898] Curr Opin Pulm Med. 2008 Mar;14(2):105-9 [18303418] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] Am J Epidemiol. 2008 Apr 15;167(8):970-5 [18250081] Am J Respir Crit Care Med. 2008 May 1;177(9):941-6 [18434333] Nat Genet. 2008 May;40(5):616-22 [18385676] Arch Intern Med. 2008 May 26;168(10):1097-103 [18504338] BMC Public Health. 2008;8:203 [18538025] Cancer Res. 2008 Sep 1;68(17):6913-21 [18757405] Cancer Causes Control. 2000 Oct;11(9):853-8 [11075875] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0007380 ER - TY - JOUR T1 - Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. AN - 67688697; 19617899 AB - Growing evidence indicates that microRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we evaluated the clinical and functional relevance of microRNA-122 (miR-122) expression in human hepatocellular carcinoma (HCC). We report that miR-122 is specifically repressed in a subset of primary tumors that are characterized by poor prognosis. We further show that the loss of miR-122 expression in tumor cells segregates with specific gene expression profiles linked to cancer progression, namely the suppression of hepatic phenotype and the acquisition of invasive properties. We identify liver-enriched transcription factors as central regulatory molecules in the gene networks associated with loss of miR-122, and provide evidence suggesting that miR-122 is under the transcriptional control of HNF1A, HNF3A and HNF3B. We further show that loss of miR-122 results in an increase of cell migration and invasion and that restoration of miR-122 reverses this phenotype. In conclusion, miR-122 is a marker of hepatocyte-specific differentiation and an important determinant in the control of cell migration and invasion. From a clinical point of view, our study emphasizes miR-122 as a diagnostic and prognostic marker for HCC progression. JF - Oncogene AU - Coulouarn, C AU - Factor, V M AU - Andersen, J B AU - Durkin, M E AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892-4262, MD, USA. Y1 - 2009/10/08/ PY - 2009 DA - 2009 Oct 08 SP - 3526 EP - 3536 VL - 28 IS - 40 KW - MIRN122 microRNA, human KW - 0 KW - MicroRNAs KW - Index Medicus KW - Phenotype KW - Neoplasm Invasiveness KW - Gene Expression Profiling KW - Humans KW - Prognosis KW - Neoplasm Metastasis KW - Cell Line, Tumor KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- mortality KW - Carcinoma, Hepatocellular -- pathology KW - MicroRNAs -- analysis KW - MicroRNAs -- physiology KW - Carcinoma, Hepatocellular -- mortality KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67688697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Loss+of+miR-122+expression+in+liver+cancer+correlates+with+suppression+of+the+hepatic+phenotype+and+gain+of+metastatic+properties.&rft.au=Coulouarn%2C+C%3BFactor%2C+V+M%3BAndersen%2C+J+B%3BDurkin%2C+M+E%3BThorgeirsson%2C+S+S&rft.aulast=Coulouarn&rft.aufirst=C&rft.date=2009-10-08&rft.volume=28&rft.issue=40&rft.spage=3526&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2009.211 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2002 May;35(5):1134-43 [11981763] Hepatology. 2009 May;49(5):1571-82 [19296470] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Science. 2004 Feb 27;303(5662):1378-81 [14988562] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004 [14973191] Hepatology. 2004 Sep;40(3):667-76 [15349906] Nature. 2004 Sep 16;431(7006):350-5 [15372042] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] FEBS Lett. 1995 Sep 18;372(1):25-8 [7556636] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Science. 2005 Sep 2;309(5740):1577-81 [16141076] Nature. 2005 Dec 1;438(7068):685-9 [16258535] Cell Metab. 2006 Feb;3(2):87-98 [16459310] Hepatology. 2006 Feb;43(2 Suppl 1):S145-50 [16447291] N Engl J Med. 2006 Mar 16;354(11):1194-5 [16540623] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] Nat Med. 2006 Apr;12(4):410-6 [16532004] Oncogene. 2006 Apr 20;25(17):2537-45 [16331254] J Clin Invest. 2006 Jun;116(6):1582-95 [16710476] J Cell Biochem. 2006 Oct 15;99(3):671-8 [16924677] Hepatology. 2006 Oct;44(4):1003-11 [17006931] RNA Biol. 2004 Jul;1(2):106-13 [17179747] Semin Liver Dis. 2007 Feb;27(1):55-76 [17295177] Cancer Res. 2007 Jul 1;67(13):6092-9 [17616664] RNA. 2007 Oct;13(10):1803-22 [17675362] Nature. 2008 Jan 10;451(7175):147-52 [18185580] Hepatology. 2008 Mar;47(3):897-907 [18176954] J Hepatol. 2008 Apr;48(4):648-56 [18291553] Hepatology. 2008 Apr;47(4):1223-32 [18307259] Nature. 2008 Apr 17;452(7189):896-9 [18368051] Genes Dev. 2008 Jun 1;22(11):1439-44 [18519636] Hepatology. 2008 Jun;47(6):1955-63 [18433021] Hepatology. 2008 Jun;47(6):1807-9 [18506877] Hepatology. 2008 Jun;47(6):2059-67 [18506891] Gastroenterology. 2008 Jul;135(1):257-69 [18555017] J Virol. 2008 Aug;82(16):8215-23 [18550664] Int J Cancer. 2008 Oct 1;123(7):1616-22 [18649363] Biochem Biophys Res Commun. 2008 Oct 24;375(3):315-20 [18692484] Mol Cell Biol. 2008 Nov;28(22):6773-84 [18794355] PLoS One. 2008;3(11):e3726 [19015728] Hepatology. 2008 Dec;48(6):1810-20 [19030170] EMBO J. 2008 Dec 17;27(24):3300-10 [19020517] Biochim Biophys Acta. 2009 Apr;1795(2):137-51 [19162129] Curr Biol. 2002 Apr 30;12(9):735-9 [12007417] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2009.211 ER - TY - JOUR T1 - MicroRNA expression, survival, and response to interferon in liver cancer. AN - 67685694; 19812400 AB - Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease. We analyzed three independent cohorts that included a total of 455 patients with hepatocellular carcinoma who had undergone radical tumor resection between 1999 and 2003. MicroRNA-expression profiling was performed in a cohort of 241 patients with hepatocellular carcinoma to identify tumor-related microRNAs and determine their association with survival in men and women. In addition, to validate our findings, we used quantitative reverse-transcriptase-polymerase-chain-reaction assays to measure microRNAs and assess their association with survival and response to therapy with interferon alfa in 214 patients from two independent, prospective, randomized, controlled trials of adjuvant interferon therapy. In patients with hepatocellular carcinoma, the expression of miR-26a and miR-26b in nontumor liver tissue was higher in women than in men. Tumors had reduced levels of miR-26 expression, as compared with paired noncancerous tissues, which indicated that the level of miR-26 expression was also associated with hepatocellular carcinoma. Moreover, tumors with reduced miR-26 expression had a distinct transcriptomic pattern, and analyses of gene networks revealed that activation of signaling pathways between nuclear factor kappaB and interleukin-6 might play a role in tumor development. Patients whose tumors had low miR-26 expression had shorter overall survival but a better response to interferon therapy than did patients whose tumors had high expression of the microRNA. The expression patterns of microRNAs in liver tissue differ between men and women with hepatocellular carcinoma. The miR-26 expression status of such patients is associated with survival and response to adjuvant therapy with interferon alfa. 2009 Massachusetts Medical Society JF - The New England journal of medicine AU - Ji, Junfang AU - Shi, Jiong AU - Budhu, Anuradha AU - Yu, Zhipeng AU - Forgues, Marshonna AU - Roessler, Stephanie AU - Ambs, Stefan AU - Chen, Yidong AU - Meltzer, Paul S AU - Croce, Carlo M AU - Qin, Lun-Xiu AU - Man, Kwan AU - Lo, Chung-Mau AU - Lee, Joyce AU - Ng, Irene O L AU - Fan, Jia AU - Tang, Zhao-You AU - Sun, Hui-Chuan AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/10/08/ PY - 2009 DA - 2009 Oct 08 SP - 1437 EP - 1447 VL - 361 IS - 15 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - MIRN26A microRNA, human KW - MicroRNAs KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Sex Factors KW - Humans KW - Gene Regulatory Networks KW - Prognosis KW - Aged KW - Liver Cirrhosis -- complications KW - Reverse Transcriptase Polymerase Chain Reaction KW - Pharmacogenetics KW - Gene Expression Profiling KW - Hepatitis B -- complications KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Survival Analysis KW - Proportional Hazards Models KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - MicroRNAs -- metabolism KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- mortality KW - Gene Expression KW - Carcinoma, Hepatocellular -- mortality KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=MicroRNA+expression%2C+survival%2C+and+response+to+interferon+in+liver+cancer.&rft.au=Ji%2C+Junfang%3BShi%2C+Jiong%3BBudhu%2C+Anuradha%3BYu%2C+Zhipeng%3BForgues%2C+Marshonna%3BRoessler%2C+Stephanie%3BAmbs%2C+Stefan%3BChen%2C+Yidong%3BMeltzer%2C+Paul+S%3BCroce%2C+Carlo+M%3BQin%2C+Lun-Xiu%3BMan%2C+Kwan%3BLo%2C+Chung-Mau%3BLee%2C+Joyce%3BNg%2C+Irene+O+L%3BFan%2C+Jia%3BTang%2C+Zhao-You%3BSun%2C+Hui-Chuan%3BWang%2C+Xin+Wei&rft.aulast=Ji&rft.aufirst=Junfang&rft.date=2009-10-08&rft.volume=361&rft.issue=15&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa0901282 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-16 N1 - Date created - 2009-10-08 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Jpn J Cancer Res. 2001 Mar;92(3):249-56 [11267934] Hepatology. 2003 Feb;37(2):429-42 [12540794] J Gastroenterol Hepatol. 2003 Mar;18(3):267-72 [12603526] Hepatology. 2004 Feb;39(2):518-27 [14768006] World J Gastroenterol. 2004 Jun 1;10(11):1547-50 [15162522] Cancer. 1995 Jan 1;75(1):18-22 [7804971] Hepatology. 1998 Feb;27(2):383-91 [9462635] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Gastric Cancer. 2005;8(2):124-31 [15864720] Nature. 2005 Jun 9;435(7043):834-8 [15944708] N Engl J Med. 2005 Oct 27;353(17):1793-801 [16251535] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] J Cancer Res Clin Oncol. 2006 Jul;132(7):458-65 [16557381] Ann Surg. 2007 Jun;245(6):831-42 [17522506] Ann Surg. 2007 Jun;245(6):843-5 [17522507] Gastroenterology. 2007 Jun;132(7):2557-76 [17570226] Science. 2007 Jul 6;317(5834):121-4 [17615358] Exp Cell Res. 2007 Nov 15;313(19):4015-24 [17880940] N Engl J Med. 2007 Nov 8;357(19):1974-6 [17989393] Cancer Res. 2007 Dec 15;67(24):11536-46 [18089782] JAMA. 2008 Jan 30;299(4):425-36 [18230780] Ann Oncol. 2008 Feb;19(2):353-8 [17962206] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] Hepatology. 2008 Mar;47(3):897-907 [18176954] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Comment In: N Engl J Med. 2009 Oct 8;361(15):1500-1 [19812408] Gastroenterology. 2010 Apr;138(4):1624-6; discussion 1626-7 [20175966] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMoa0901282 ER - TY - CPAPER T1 - Expression of p53 family of proteins and VEGF in colorectal carcinoma and adenoma: correlation with survival and response to treatment T2 - 2009 Cancer Conference of the National Cancer Research Institute AN - 42465946; 5424835 JF - 2009 Cancer Conference of the National Cancer Research Institute AU - Bahnassy, Abeer AU - Zekri, Abdel AU - El Borai, Mohamed AU - Aboubakr, Amany AU - Al badri, Manal AU - Anwar, Nayera AU - Al Serafi, Moustafa Y1 - 2009/10/04/ PY - 2009 DA - 2009 Oct 04 KW - Colorectal carcinoma KW - Survival KW - Colorectal cancer KW - P53 protein KW - Adenoma KW - Vascular endothelial growth factor KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42465946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.atitle=Expression+of+p53+family+of+proteins+and+VEGF+in+colorectal+carcinoma+and+adenoma%3A+correlation+with+survival+and+response+to+treatment&rft.au=Bahnassy%2C+Abeer%3BZekri%2C+Abdel%3BEl+Borai%2C+Mohamed%3BAboubakr%2C+Amany%3BAl+badri%2C+Manal%3BAnwar%2C+Nayera%3BAl+Serafi%2C+Moustafa&rft.aulast=Bahnassy&rft.aufirst=Abeer&rft.date=2009-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.issn=&rft_id=info:doi/ L2 - http://www.ncri.org.uk/ncriconference/2009abstracts/search.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Needle Oophropexy: A New Simple Technique for Ovarian Transposition Prior to Pelvic Irradiation T2 - 2009 Cancer Conference of the National Cancer Research Institute AN - 42462713; 5424972 JF - 2009 Cancer Conference of the National Cancer Research Institute AU - Gareer, Waheed AU - Gad, Zeiad Y1 - 2009/10/04/ PY - 2009 DA - 2009 Oct 04 KW - Irradiation KW - Radiation KW - Pelvis KW - Transposition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42462713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.atitle=Needle+Oophropexy%3A+A+New+Simple+Technique+for+Ovarian+Transposition+Prior+to+Pelvic+Irradiation&rft.au=Gareer%2C+Waheed%3BGad%2C+Zeiad&rft.aulast=Gareer&rft.aufirst=Waheed&rft.date=2009-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.issn=&rft_id=info:doi/ L2 - http://www.ncri.org.uk/ncriconference/2009abstracts/search.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular epidemiology of infection-related cancer T2 - 2009 Cancer Conference of the National Cancer Research Institute AN - 42460623; 5425040 JF - 2009 Cancer Conference of the National Cancer Research Institute AU - Rabkin, Charles Y1 - 2009/10/04/ PY - 2009 DA - 2009 Oct 04 KW - Cancer KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42460623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.atitle=Molecular+epidemiology+of+infection-related+cancer&rft.au=Rabkin%2C+Charles&rft.aulast=Rabkin&rft.aufirst=Charles&rft.date=2009-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.issn=&rft_id=info:doi/ L2 - http://www.ncri.org.uk/ncriconference/2009abstracts/search.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA ploidy and proliferative activity in common round cell tumours in children and their value as prognostic indicators T2 - 2009 Cancer Conference of the National Cancer Research Institute AN - 42460497; 5424665 JF - 2009 Cancer Conference of the National Cancer Research Institute AU - Raafat, Amira AU - Mahmoud, Sonia AU - El Gerzawi, Shadia AU - El Serafi, Moustafa Y1 - 2009/10/04/ PY - 2009 DA - 2009 Oct 04 KW - Children KW - Tumors KW - Ploidy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42460497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.atitle=DNA+ploidy+and+proliferative+activity+in+common+round+cell+tumours+in+children+and+their+value+as+prognostic+indicators&rft.au=Raafat%2C+Amira%3BMahmoud%2C+Sonia%3BEl+Gerzawi%2C+Shadia%3BEl+Serafi%2C+Moustafa&rft.aulast=Raafat&rft.aufirst=Amira&rft.date=2009-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Cancer+Conference+of+the+National+Cancer+Research+Institute&rft.issn=&rft_id=info:doi/ L2 - http://www.ncri.org.uk/ncriconference/2009abstracts/search.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electrochemical Evaluation of High Voltage Cathode with a Surface Coating of an Ionically Conducting Oxide T2 - 216th Meeting of the Electrochemical Society (216th ECS) AN - 42049251; 5498310 JF - 216th Meeting of the Electrochemical Society (216th ECS) AU - Dai, J AU - Skandan, G AU - Nagasubramanian, G Y1 - 2009/10/04/ PY - 2009 DA - 2009 Oct 04 KW - Coating materials KW - Electrochemistry KW - Cathodes KW - Oxides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42049251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=216th+Meeting+of+the+Electrochemical+Society+%28216th+ECS%29&rft.atitle=Electrochemical+Evaluation+of+High+Voltage+Cathode+with+a+Surface+Coating+of+an+Ionically+Conducting+Oxide&rft.au=Dai%2C+J%3BSkandan%2C+G%3BNagasubramanian%2C+G&rft.aulast=Dai&rft.aufirst=J&rft.date=2009-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=216th+Meeting+of+the+Electrochemical+Society+%28216th+ECS%29&rft.issn=&rft_id=info:doi/ L2 - http://www.electrochem.org/meetings/biannual/216/assets/216_mtg_progra m.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors AN - 21087315; 11091822 AB - To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable tetracycline-repressible locus. Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3. ChIP-Seq revealed that CDX2 binds to promoters of upregulated target genes. By contrast, genes downregulated by CDX2 did not show CDX2 binding but were enriched with binding sites for POU5F1, SOX2, and NANOG. Genes with binding sites for these core TFs were also downregulated by the induction of at least 15 other TFs, suggesting a common initial step for ESC differentiation mediated by interference with the binding of core TFs to their target genes. These ESC lines provide a fundamental resource to study biological networks in ESCs and mice. JF - Cell Stem Cell AU - Nishiyama, Akira AU - Xin, Li AU - Sharov, Alexei A AU - Thomas, Marshall AU - Mowrer, Gregory AU - Meyers, Emily AU - Piao, Yulan AU - Mehta, Samir AU - Yee, Sarah AU - Nakatake, Yuhki AU - Stagg, Carole AU - Sharova, Lioudmila AU - Correa-Cerro, Lina S AU - Bassey, Uwem AU - Hoang, Hien AU - Kim, Eugene AU - Tapnio, Richard AU - Qian, Yong AU - Dudekula, Dawood AU - Zalzman, Michal AU - Li, Manxiang AU - Falco, Geppino AU - Yang, Hsih-Te AU - Lee, Sung-Lim AU - Monti, Manuela AU - Stanghellini, Ilaria AU - Islam, MdNurul AU - Nagaraja, Ramaiah AU - Goldberg, Ilya AU - Wang, Weidong AU - Longo, Dan L AU - Schlessinger, David AU - Ko, Minoru SH AD - National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, kom@mail.nih.gov Y1 - 2009/10/02/ PY - 2009 DA - 2009 Oct 02 SP - 420 EP - 433 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 5 IS - 4 SN - 1934-5909, 1934-5909 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Promoters KW - Differentiation KW - Stem cells KW - CDX2 protein KW - Transcription factors KW - KLF4 protein KW - Oct-4 protein KW - Sox9 protein KW - GATA-3 protein KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21087315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Uncovering+Early+Response+of+Gene+Regulatory+Networks+in+ESCs+by+Systematic+Induction+of+Transcription+Factors&rft.au=Nishiyama%2C+Akira%3BXin%2C+Li%3BSharov%2C+Alexei+A%3BThomas%2C+Marshall%3BMowrer%2C+Gregory%3BMeyers%2C+Emily%3BPiao%2C+Yulan%3BMehta%2C+Samir%3BYee%2C+Sarah%3BNakatake%2C+Yuhki%3BStagg%2C+Carole%3BSharova%2C+Lioudmila%3BCorrea-Cerro%2C+Lina+S%3BBassey%2C+Uwem%3BHoang%2C+Hien%3BKim%2C+Eugene%3BTapnio%2C+Richard%3BQian%2C+Yong%3BDudekula%2C+Dawood%3BZalzman%2C+Michal%3BLi%2C+Manxiang%3BFalco%2C+Geppino%3BYang%2C+Hsih-Te%3BLee%2C+Sung-Lim%3BMonti%2C+Manuela%3BStanghellini%2C+Ilaria%3BIslam%2C+MdNurul%3BNagaraja%2C+Ramaiah%3BGoldberg%2C+Ilya%3BWang%2C+Weidong%3BLongo%2C+Dan+L%3BSchlessinger%2C+David%3BKo%2C+Minoru+SH&rft.aulast=Nishiyama&rft.aufirst=Akira&rft.date=2009-10-02&rft.volume=5&rft.issue=4&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2009.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Gene expression; Differentiation; Promoters; Stem cells; CDX2 protein; Transcription factors; KLF4 protein; Sox9 protein; Oct-4 protein; GATA-3 protein DO - http://dx.doi.org/10.1016/j.stem.2009.07.012 ER - TY - JOUR T1 - Automatic high-order shimming using parallel columns mapping (PACMAP) AN - 883036182; 15255299 AB - This work presents a new automatic high-order shimming method that maps the B0 field using a group of parallel columns. We found that a pair of four columns in two separate slices could determine an optimal correction field comprising the spherical harmonic terms up to the third-order. The technique of multiple stimulated echoes was incorporated into the method, allowing the use of at least eight shots to accomplish field mapping. The shim currents were first determined in the logic frame by assuming that the slices were in axial planes, and then uniquely converted into the physical frame where the slices could be at any oblique angle, by using a spherical harmonics rotation transformation. This method thus works regardless of slice orientation. It was demonstrated on a 3T scanner equipped with a complete set of second-order harmonic shim coils. Both phantom and in vivo experiments showed that this newly introduced high-order shimming method is an effective and efficient way to reduce field inhomogeneity for a region of imaging slices. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Zhang, Yan AU - Li, Shizhe AU - Shen, Jun Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1073 EP - 1079 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 4 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - N.M.R. KW - Mapping KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Automatic+high-order+shimming+using+parallel+columns+mapping+%28PACMAP%29&rft.au=Zhang%2C+Yan%3BLi%2C+Shizhe%3BShen%2C+Jun&rft.aulast=Zhang&rft.aufirst=Yan&rft.date=2009-10-01&rft.volume=62&rft.issue=4&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22077 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22077/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; N.M.R.; Mapping; imaging DO - http://dx.doi.org/10.1002/mrm.22077 ER - TY - JOUR T1 - Prospective head-movement correction for high-resolution MRI using an in-bore optical tracking system AN - 883035980; 15255281 AB - In MRI of the human brain, subject motion is a major cause of magnetic resonance image quality degradation. To compensate for the effects of head motion during data acquisition, an in-bore optical motion tracking system is proposed. The system comprises two MR-compatible infrared cameras that are fixed on a holder right above and in front of the head coil. The resulting close proximity of the cameras to the object allows precise tracking of its movement. During image acquisition, the MRI scanner uses this tracking information to prospectively compensate for head motion by adjusting the gradient field direction and radio frequency (RF) phases and frequencies. Experiments performed on subjects demonstrate robust system performance with translation and rotation accuracies of 0.1 mm and 0.15 degree , respectively. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Qin, Lei AU - van Gelderen, Peter AU - Derbyshire, John Andrew AU - Jin, Fenghua AU - Lee, Jongho AU - de Zwart, Jacco A AU - Tao, Yang AU - Duyn, Jeff H AD - Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, jhd@helix.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 924 EP - 934 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 4 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883035980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Prospective+head-movement+correction+for+high-resolution+MRI+using+an+in-bore+optical+tracking+system&rft.au=Qin%2C+Lei%3Bvan+Gelderen%2C+Peter%3BDerbyshire%2C+John+Andrew%3BJin%2C+Fenghua%3BLee%2C+Jongho%3Bde+Zwart%2C+Jacco+A%3BTao%2C+Yang%3BDuyn%2C+Jeff+H&rft.aulast=Qin&rft.aufirst=Lei&rft.date=2009-10-01&rft.volume=62&rft.issue=4&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22076 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22076/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/mrm.22076 ER - TY - JOUR T1 - Theory of Q-ball imaging redux: Implications for fiber tracking AN - 883035963; 15255280 AB - Q-ball imaging is widely used to determine fiber directions for fiber tracking. In q-ball imaging the directional dependence of water diffusion in tissue is described by Tuch's orientation distribution function (ODF); a different function, the q-ball orientation distribution function, is measured using high angular resolution magnetic resonance diffusion imaging (HARDI). Tuch's ODF is assumed to be well approximated by the q-ball ODF. In this study it is shown that: 1) the q-ball ODF is not a good approximation to Tuch's ODF; 2) the properties of the q-ball ODF depend strongly on q, the area of the diffusion sensitization gradients; and 3) the q-ball ODF for a composite system is the weighted average of the q-ball ODFs for each subsystem, but the weighting factor is the product of the percent composition and a renormalization factor. In addition, a derivation is presented of the q-ball ODF for a system described by a Gaussian distribution and expressions are derived for both the dependence of the angular resolution on q and for the relation between the angular resolution and the signal loss. These findings might be useful in the design and interpretation of fiber-tracking experiments. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Barnett, Alan Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 910 EP - 923 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 4 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - Magnetic resonance imaging KW - Diffusion KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883035963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Theory+of+Q-ball+imaging+redux%3A+Implications+for+fiber+tracking&rft.au=Barnett%2C+Alan&rft.aulast=Barnett&rft.aufirst=Alan&rft.date=2009-10-01&rft.volume=62&rft.issue=4&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22073 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22073/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fibers; Magnetic resonance imaging; N.M.R.; Diffusion; imaging DO - http://dx.doi.org/10.1002/mrm.22073 ER - TY - JOUR T1 - Comprehensive management of psychogenic dysphonia: A case illustration AN - 85706500; 200916545 AB - Psychogenic dysphonia refers to the loss of voice, in the absence of apparent structural or neurological pathology. It is a disorder seen more often in women and is usually associated with significant life events and emotional difficulties that may lead to conflict over speaking. Therapeutic interventions in voice disorders recommend the adoption of a multidisciplinary approach to treatment. The following is a case illustration of a 50-year-old married lady with dysphonia and significant marital difficulties. Learning outcomes: The case demonstrates the psychological issues in the onset and maintenance of psychogenic voice disorders. It also emphasizes the use of a multidisciplinary approach consisting of cognitive behavioural strategies, pharmacological inputs and voice therapy. The case illustration will also help the reader to focus on cultural issues relevant in the development of problems and the need to address these in psychotherapeutic interventions, as well as difficulties that are likely to be encountered in therapeutic interventions. [Copyright Elsevier Science Inc.] JF - Journal of Communication Disorders AU - Sudhir, Paulomi M AU - Chandra, Prabha S AU - Shivashankar, N AU - Yamini, B K AD - Department of Mental Health and Social Psychology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India paulomi@nimhans.kar.nic.in Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 305 EP - 312 VL - 42 IS - 5 SN - 0021-9924, 0021-9924 KW - Females (24000) KW - Language Therapy (44400) KW - Emotional Disturbances (21570) KW - Speech Pathology (82650) KW - Dysphonia (20270) KW - Language Pathology (43250) KW - Speech Therapy (83200) KW - Case Studies (10820) KW - article KW - 6410: language-pathological and normal; language and speech pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85706500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Comprehensive+management+of+psychogenic+dysphonia%3A+A+case+illustration&rft.au=Sudhir%2C+Paulomi+M%3BChandra%2C+Prabha+S%3BShivashankar%2C+N%3BYamini%2C+B+K&rft.aulast=Sudhir&rft.aufirst=Paulomi&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Dysphonia (20270); Emotional Disturbances (21570); Language Pathology (43250); Speech Pathology (82650); Females (24000); Case Studies (10820); Language Therapy (44400); Speech Therapy (83200) ER - TY - JOUR T1 - Communicative acts of children with autism spectrum disorders in the second year of life. AN - 85387961; pmid-19635941 AB - To examine the communicative profiles of children with autism spectrum disorders (ASD) in the second year of life.Communicative acts were examined in 125 children 18 to 24 months of age: 50 later diagnosed with ASD; 25 with developmental delays (DD); and 50 with typical development (TD). Precise measures of rate, functions, and means of communication were obtained through systematic observation of videotaped behavior samples from the Communication and Symbolic Behavior Scales Developmental Profile (A. Wetherby & B. Prizant, 2002).Children with ASD communicated at a significantly lower rate than children with DD and TD. The ASD group used a significantly lower proportion of acts for joint attention and a significantly lower proportion of deictic gestures with a reliance on more primitive gestures compared with the DD and TD groups. Children with ASD who did communicate for joint attention were as likely as other children to coordinate vocalizations, eye gaze, and gestures. Rate of communicative acts and joint attention were the strongest predictors of verbal outcome at age 3.By 18 to 24 months of age, children later diagnosed with ASD showed a unique profile of communication, with core deficits in communication rate, joint attention, and communicative gestures. JF - Journal of speech, language, and hearing research : JSLHR AU - Shumway, Stacy AU - Wetherby, Amy M AD - Pediatric & Developmental Neuroscience Branch, National Institute of Mental Health, Bethesda, MD, USA. shumways@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1139 EP - 1156 VL - 52 IS - 5 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - Attention KW - *Autistic Disorder: epidemiology KW - *Autistic Disorder: psychology KW - Child, Preschool KW - *Communication KW - Female KW - Gestures KW - Humans KW - Infant KW - Language Development KW - Male KW - Observer Variation KW - Predictive Value of Tests KW - *Social Behavior KW - *Verbal Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Communicative+acts+of+children+with+autism+spectrum+disorders+in+the+second+year+of+life.&rft.au=Shumway%2C+Stacy%3BWetherby%2C+Amy+M&rft.aulast=Shumway&rft.aufirst=Stacy&rft.date=2009-10-01&rft.volume=52&rft.issue=5&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: Pediatrics. 2007 Nov;120(5):1183-215[17967920]; Cites: Dev Psychopathol. 2002 Spring;14(2):239-51[12030690]; Cites: J Autism Dev Disord. 2007 May;37(5):960-75[17066310]; Cites: J Autism Dev Disord. 2007 Apr;37(4):648-66[17051443]; Cites: J Autism Dev Disord. 2007 Feb;37(2):301-13[17031450]; Cites: J Child Psychol Psychiatry. 2007 Feb;48(2):128-38[17300551]; Cites: Child Neuropsychol. 2006 Aug;12(4-5):307-19[16911975]; Cites: Arch Gen Psychiatry. 2006 Jun;63(6):694-701[16754843]; Cites: J Child Psychol Psychiatry. 2006 Jun;47(6):629-38[16712640]; Cites: J Autism Dev Disord. 2005 Jun;35(3):337-50[16119475]; Cites: Arch Gen Psychiatry. 2005 Aug;62(8):889-95[16061766]; Cites: J Child Psychol Psychiatry. 2005 May;46(5):500-13[15845130]; Cites: Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52[15749241]; Cites: J Autism Dev Disord. 2004 Oct;34(5):473-93[15628603]; Cites: J Child Psychol Psychiatry. 1999 Jul;40(5):719-32[10433406]; Cites: J Child Psychol Psychiatry. 1999 Feb;40(2):219-26[10188704]; Cites: J Child Psychol Psychiatry. 1998 Jul;39(5):747-53[9690937]; Cites: J Pediatr. 1998 Mar;132(3 Pt 1):500-4[9544908]; Cites: J Autism Dev Disord. 1997 Dec;27(6):677-96[9455728]; Cites: Dev Psychol. 1997 Sep;33(5):781-9[9300211]; Cites: J Child Psychol Psychiatry. 1995 Nov;36(8):1383-98[8988273]; Cites: J Child Psychol Psychiatry. 1995 Nov;36(8):1365-82[8988272]; Cites: J Autism Dev Disord. 1994 Jun;24(3):247-57[8050980]; Cites: J Autism Dev Disord. 1990 Dec;20(4):437-53[2279967]; Cites: J Child Psychol Psychiatry. 1986 Sep;27(5):647-55[3771681]; Cites: J Autism Dev Disord. 1990 Mar;20(1):115-28[2324051]; Cites: J Autism Dev Disord. 2004 Feb;34(1):7-17[15098952]; Cites: Dev Psychol. 2004 Mar;40(2):271-83[14979766]; Cites: J Autism Dev Disord. 2007 Oct;37(9):1721-34[17180717] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Impaired spatial navigation in pediatric anxiety AN - 839575389; 201103015 AB - Background: Previous theories implicate hippocampal dysfunction in anxiety disorders. Most of the data supporting these theories stem from animal research, particularly lesion studies. The generalization of findings from rodent models to human function is hampered by fundamental inter-species differences. The present work uses a task of spatial orientation, which is known to rely on hippocampal function. Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders. Methods: Thirty-four treatment-naive children with an anxiety disorder (mean 11.00 years ^c 2.54) are compared to 35 healthy age- and IQ-matched healthy children (mean 11.95 years ^c 2.36) on a virtual, computer-based equivalent of the Morris Water Maze task. Results: Results indicate that children with anxiety disorder exhibit overall impaired performance relative to the comparison group. Anxious children made more heading direction errors and had worse accuracy in completing trials relative to controls. Conclusions: The results present novel evidence that spatial orientation deficits occur in pediatric anxiety. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Mueller, Sven C AU - Temple, Veronica AU - Cornwell, Brian AU - Grillon, Christian AU - Pine, Daniel S AU - Ernst, Monique AD - MAP, NIMH, NIH, Bethesda, MD, USA Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1227 EP - 1234 PB - Blackwell Publishing, Oxford UK VL - 50 IS - 10 SN - 0021-9630, 0021-9630 KW - Pediatric anxiety hippocampus water maze spatial navigation KW - Paediatrics KW - Anxiety disorders KW - Dysfunction KW - Navigation KW - Children KW - Water KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839575389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Impaired+spatial+navigation+in+pediatric+anxiety&rft.au=Mueller%2C+Sven+C%3BTemple%2C+Veronica%3BCornwell%2C+Brian%3BGrillon%2C+Christian%3BPine%2C+Daniel+S%3BErnst%2C+Monique&rft.aulast=Mueller&rft.aufirst=Sven&rft.date=2009-10-01&rft.volume=50&rft.issue=10&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2009.02112.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Children; Anxiety disorders; Navigation; Paediatrics; Dysfunction; Water DO - http://dx.doi.org/10.1111/j.1469-7610.2009.02112.x ER - TY - JOUR T1 - Genetic structure in contemporary South Tyrolean isolated populations revealed by analysis of y-chromosome, mtDNA, and alu polymorphisms AN - 757458850; 4111008 AB - Most of the inhabitants of South Tyrol in the eastern Italian Alps can be considered isolated populations because of their physical separation by mountain barriers and their sociocultural heritage. We analyzed the genetic structure of South Tyrolean populations using three types of genetic markers: Y-chromosome, mitochondrial DNA (mtDNA), and autosomal Alu markers. Using random samples taken from the populations of Val Venosta, Val Pusteria, Val Isarco, Val Badia, and Val Gardena, we calculated genetic diversity within and among the populations. Microsatellite diversity and unique event polymorphism diversity (on the Y chromosome) were substantially lower in the Ladin-speaking population of Val Badia compared to the neighboring German-speaking populations. In contrast, the genetic diversity of mtDNA haplotypes was lowest for the upper Val Venosta and Val Pusteria. These data suggest a low effective population size, or little admixture, for the gene pool of the Ladin-speaking population from Val Badia. Interestingly, this is more pronounced for Ladin males than for Ladin females. For the pattern of genetic Alu variation, both Ladin samples (Val Gardena and Val Badia) are among the samples with the lowest diversity. An admixture analysis of one German-speaking valley (Val Venosta) indicates a relatively high genetic contribution of Ladin origin. The reduced genetic diversity and a high genetic differentiation in the Rhaetoroman-and German-speaking South Tyrolean populations may constitute an important basis for future medical genetic research and gene mapping studies in South Tyrol. Reprinted with the permission of Wayne University Press JF - Human biology AU - Pichler, Irene AU - Mueller, Jakob C AU - Stefanov, Stefan A AU - Grandi, Alessandro de AU - Volpato, Claudia Beu AU - Pinggera, Gerd K AU - Mayr, Agnes AU - Ogriseg, Martin AU - Ploner, Franz AU - Meitinger, Thomas AU - Pramstaller, Peter P AD - European Academy of Bolzano ; Ludwig-Maximiliams-Universität München ; National Cancer Institute, Maryland ; Hospital of Brunico ; Hospital of Bressanone ; Hospital of Vipiteno ; National Research Institute for Environment and Health Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 875 EP - 898 VL - 81 IS - 5-6 SN - 1534-6617, 1534-6617 KW - Anthropology KW - Polymorphism KW - Biological anthropology KW - Human biology KW - Chromosomes KW - Human genetics KW - Variance KW - Cultural heritage KW - Social isolation KW - DNA KW - Population UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757458850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+biology&rft.atitle=Genetic+structure+in+contemporary+South+Tyrolean+isolated+populations+revealed+by+analysis+of+y-chromosome%2C+mtDNA%2C+and+alu+polymorphisms&rft.au=Pichler%2C+Irene%3BMueller%2C+Jakob+C%3BStefanov%2C+Stefan+A%3BGrandi%2C+Alessandro+de%3BVolpato%2C+Claudia+Beu%3BPinggera%2C+Gerd+K%3BMayr%2C+Agnes%3BOgriseg%2C+Martin%3BPloner%2C+Franz%3BMeitinger%2C+Thomas%3BPramstaller%2C+Peter+P&rft.aulast=Pichler&rft.aufirst=Irene&rft.date=2009-10-01&rft.volume=81&rft.issue=5-6&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Human+biology&rft.issn=15346617&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6081 5460 1615 8573 11325; 9846; 11862; 3143 3192 12867; 3254 5460 1615 8573 11325; 2257 5455 1678; 13249 10214 12224 971; 6072 1615 8573 11325; 1608 1077 ER - TY - JOUR T1 - Sociocultural contexts and communication about sex in China: informing HIV/STD prevention programs AN - 757458553; 4110589 AB - HIV may be particularly stigmatizing in Asia because of its association with `taboo' topics, including sex, drugs, homosexuality, and death (Aoki, Ngin, Mo, & Ja, 1989). These cultural schemata expose salient boundaries and moral implications for sexual communication (Chin, 1999, Social Science and Medicine, 49, 241-251). Yet HIV/STD prevention efforts are frequently conducted in the public realm. Education strategies often involve conversations with health `experts' about condom use, safe sex, and partner communication. The gap between the public context of intervention efforts and the private and norm-bound nature of sex conversation is particularly challenging. Interviews with 32 market workers in eastern China focused on knowledge, beliefs, and values surrounding sexual practices, meanings, and communication. Sex-talk taboos, information seeking, vulnerability, partner communication, and cultural change emerged as central to understanding intervention information flow and each theme's relative influence is described. Findings illustrate the nature of how sexual communication schemata in Chinese contexts impact the effectiveness of sexual health message communication. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Leiber, Eli AU - Chin, Dorothy AU - Li, Li AU - Rotheram-Borus, Mary Jane AU - Detels, Roger AU - Wu, Zunyou AU - Guan, Jihui AD - University of California, Los Angeles ; Chinese Center for Disease Control and Prevention ; Fujian Institute of Health Education Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 415 EP - 429 VL - 21 IS - 5 SN - 0899-9546, 0899-9546 KW - Sociology KW - Prevention KW - Epidemics KW - AIDS KW - Communication KW - HIV KW - China KW - Sexually transmitted diseases KW - Public health KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757458553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Sociocultural+contexts+and+communication+about+sex+in+China%3A+informing+HIV%2FSTD+prevention+programs&rft.au=Leiber%2C+Eli%3BChin%2C+Dorothy%3BLi%2C+Li%3BRotheram-Borus%2C+Mary+Jane%3BDetels%2C+Roger%3BWu%2C+Zunyou%3BGuan%2C+Jihui&rft.aulast=Leiber&rft.aufirst=Eli&rft.date=2009-10-01&rft.volume=21&rft.issue=5&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11581 3617 6220; 2572; 5703 3617 6220; 482 3617 6220; 4356 3617 6220; 10072; 5790 5772; 10449 5772; 93 116 30 ER - TY - JOUR T1 - Estimation of tumor microvessel density by MRI using a blood pool contrast agent AN - 755139047; 13647233 AB - Recognition of importance of angiogenesis to tumor growth, metastasis, and treatment outcome has led to efforts to develop non-invasive methods for longitudinal monitoring of tumor microvasculature. We describe a steady-state MRI technique to determine absolute blood volume (BV) as a marker of microvascular density with improved spatial and temporal resolution using an ultra small super paramagnetic iron oxide (USPIO). A noise reduction scheme for BV imaging was also proposed based on weighting factors derived by pre-contrast signal level as an adjustable additive constant. Gradient echo sequence was used for BV imaging with MRI at 7T. Optimal imaging conditions (USPIO dose and echo time) were determined by USPIO dose-dependent studies ex vivo and in vivo. Improved analysis strategies were at first applied for cerebral BV estimation in mice, which were found in good agreement with the literature values. These methods were then used to determine tumor BV in mice. The optimal concentration of USPIO for BV estimates was found to range from 3.6 to 4.48 mM (estimated as Fe concentration) in ex vivo experiments corresponding to an in vivo dosage of 215-287 mu mol/kg body weight, whereas a USPIO dose of 287 mu mol/kg leads to higher cerebral BV estimate in vivo than the reported values. Application of the BV imaging method to evaluation of antl-angiogenic effect of Sunitinib in squamous cell carcinoma (SCC) tumor bearing mice revealed approximately 46% reduction in tumor BV 4 days after start of Sunitinib treatment. The results show that the MRI approach using USPIO yields high-resolution absolute BV images and the method can be conveniently applied to monitor longitudinal tumor microvessel density changes as a function of growth or in response to treatment. JF - International Journal of Oncology AU - Hyodo, F AU - Chandramouli, GVR AU - Matsumoto, S AU - Matsumoto, K-I AU - Mitchell, J B AU - Krishna, M C AU - Munasinghe, J P AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 797 EP - 804 VL - 35 IS - 4 SN - 1019-6439, 1019-6439 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755139047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Oncology&rft.atitle=Estimation+of+tumor+microvessel+density+by+MRI+using+a+blood+pool+contrast+agent&rft.au=Hyodo%2C+F%3BChandramouli%2C+GVR%3BMatsumoto%2C+S%3BMatsumoto%2C+K-I%3BMitchell%2C+J+B%3BKrishna%2C+M+C%3BMunasinghe%2C+J+P&rft.aulast=Hyodo&rft.aufirst=F&rft.date=2009-10-01&rft.volume=35&rft.issue=4&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Oncology&rft.issn=10196439&rft_id=info:doi/10.3892%2Fijo_00000392 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.3892/ijo_00000392 ER - TY - JOUR T1 - Panton-Valentine Leukocidin Is Associated with Exacerbated Skin Manifestations and Inflammatory Response in Children with Community-Associated Staphylococcal Scarlet Fever AN - 755136756; 13648691 AB - Background. Staphylococcal scarlet fever (SSF), a rare disease, was first described in 1900. The clinical features and outcomes in children with SSF caused by Panton-Valentine leukocidin (PVL)-positive and PVL-negative Staphylococcus aureus strains have not been compared prospectively. Methods. The demographic data, selected clinical features, laboratory values, and outcomes for 49 consecutive children with community-acquired S. aureus SSF prospectively identified during an 11-year period were collected for analysis. Results. The male-to-female ratio was 1.88, and the median age of the patients was 37 months. Cutaneous abscesses predominated among children with SSF. Methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) caused SSF in 26 and 23 children, respectively. Twenty-four isolates had results that were positive for PVL (5 MSSA and 19 MRSA isolates), and 25 had results that were negative for PVL (21 MSSA and 4 MRSA isolates). Polymerase chain reaction revealed that most (92%) contained only staphylococcal enterotoxin B (23 MSSA and 22 MRSA isolates). By multivariate analysis, children with PVL-positive isolates had significantly larger abscess sizes, higher white blood cell counts, higher C-reactlve protein levels, and longer durations of fever, generalized scariatiniform rashes, and hospital stays. Most (17 isolates; 89%) of the 19 PVL-positive MRSA isolates carried the staphylococcal cassette chromosome mec V sub(T) and all were multilocus sequence type 59. Conclusion. SSF caused by PVL-positive S. aureus strains were associated with more-exacerbated skin manifestations and a greater systemic inflammatory response, compared with those cases caused by PVL-negative S. aureus. Clinical improvement after incision and drainage was achieved for most children with SSF caused by PVL-positive MRSA strains, despite treatment with an ineffective antibiotic. JF - Clinical Infectious Diseases AU - Lo, W-T AU - Tang, C-S AU - Chen, S-J AU - Huang, C-F AU - Tseng, M-H AU - Wang, C-C AD - Dept. of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Rd., Section 2, Nei-hu 114, Taipel, Taiwan, ndmcccw@yahoo.com.tw Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - e69 EP - e75 VL - 49 IS - 7 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Scarlet fever KW - Chromosomes KW - Skin KW - leukocidin KW - Drug resistance KW - Drainage KW - Staphylococcus aureus KW - Children KW - Abscesses KW - Inflammation KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755136756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Panton-Valentine+Leukocidin+Is+Associated+with+Exacerbated+Skin+Manifestations+and+Inflammatory+Response+in+Children+with+Community-Associated+Staphylococcal+Scarlet+Fever&rft.au=Lo%2C+W-T%3BTang%2C+C-S%3BChen%2C+S-J%3BHuang%2C+C-F%3BTseng%2C+M-H%3BWang%2C+C-C&rft.aulast=Lo&rft.aufirst=W-T&rft.date=2009-10-01&rft.volume=49&rft.issue=7&rft.spage=e69&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F605580 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Scarlet fever; Chromosomes; Skin; leukocidin; Drainage; Drug resistance; Abscesses; Children; Inflammation; Staphylococcus aureus DO - http://dx.doi.org/10.1086/605580 ER - TY - JOUR T1 - Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models AN - 754882759; 13416444 AB - The lack of practicable nonlinear elastic contact models frequently compels the inappropriate use of Hertzian models in analyzing indentation data and likely contributes to inconsistencies associated with the results of biological atomic force microscopy measurements. We derived and validated with the aid of the finite element method force-indentation relations based on a number of hyperelastic strain energy functions. The models were applied to existing data from indentation, using microspheres as indenters, of synthetic rubber-like gels, native mouse cartilage tissue, and engineered cartilage. For the biological tissues, the Fung and single-term Ogden models achieved the best fits of the data while all tested hyperelastic models produced good fits for the synthetic gels. The Hertz model proved to be acceptable for the synthetic gels at small deformations (strain< 0.05 for the samples tested), but not for the biological tissues. Although this finding supports the generally accepted view that many soft materials can be assumed to be linear elastic at small deformations, the nonlinear models facilitate analysis of intrinsically nonlinear tissues and large-strain indentation behavior. JF - Biomechanics and Modeling in Mechanobiology AU - Lin, David C AU - Shreiber, David I AU - Dimitriadis, Emilios K AU - Horkay, Ferenc AD - Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, 9 Memorial Drive, Bethesda, MD, 20892, USA, lindavid@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 345 EP - 358 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 8 IS - 5 SN - 1617-7959, 1617-7959 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Gels KW - Mathematical models KW - Data processing KW - Cartilage KW - Energy KW - Animal models KW - atomic force microscopy KW - microspheres KW - Mechanical properties KW - N3 11029:Neurophysiology & biophysics KW - T 2030:Cartilage and Cartilage Diseases KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754882759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomechanics+and+Modeling+in+Mechanobiology&rft.atitle=Spherical+indentation+of+soft+matter+beyond+the+Hertzian+regime%3A+numerical+and+experimental+validation+of+hyperelastic+models&rft.au=Lin%2C+David+C%3BShreiber%2C+David+I%3BDimitriadis%2C+Emilios+K%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2009-10-01&rft.volume=8&rft.issue=5&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Biomechanics+and+Modeling+in+Mechanobiology&rft.issn=16177959&rft_id=info:doi/10.1007%2Fs10237-008-0139-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Gels; Data processing; Mathematical models; Energy; Cartilage; microspheres; atomic force microscopy; Animal models; Mechanical properties DO - http://dx.doi.org/10.1007/s10237-008-0139-9 ER - TY - JOUR T1 - Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant AN - 746277259; 12741607 AB - The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well-established in vivo. In this work we have performed microarray experiments with a spermidine synthase, spermine oxidase mutant (spe3 fms1) strain to investigate the responsiveness of yeast genes to supplementation with spermidine or spermine. Expression analysis identified genes responsive to the addition of either excess spermidine (10-5 M) or spermine (10-5 M) compared to a control culture containing 10-8 M spermidine. 247 genes were upregulated > two-fold and 11 genes were upregulated >10-fold after spermidine addition. Functional categorization of the genes showed induction of transport-related genes and genes involved in methionine, arginine, lysine, NAD and biotin biosynthesis. 268 genes were downregulated more than two-fold, and six genes were downregulated > eight-fold after spermidine addition. A majority of the downregulated genes are involved in nucleic acid metabolism and various stress responses. In contrast, only a few genes (18) were significantly responsive to spermine. Thus, results from global gene expression profiling demonstrate a more major role for spermidine in modulating gene expression in yeast than spermine. JF - Yeast AU - Chattopadhyay, Manas K AU - Chen, Weiping AU - Poy, George AU - Cam, Margaret AU - Stiles, David AU - Tabor, Herbert AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA, manasc@intra.niddk.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 531 EP - 544 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 26 IS - 10 SN - 0749-503X, 0749-503X KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Spermine KW - Arginine KW - Stress KW - Lysine KW - Cell culture KW - Supplementation KW - Methionine KW - Saccharomyces cerevisiae KW - Spermidine synthase KW - Cell division KW - Putrescine KW - nucleic acids KW - NAD KW - Spermidine KW - polyamines KW - Biotin KW - Metabolism KW - K 03410:Animal Diseases KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746277259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Yeast&rft.atitle=Microarray+studies+on+the+genes+responsive+to+the+addition+of+spermidine+or+spermine+to+a+Saccharomyces+cerevisiae+spermidine+synthase+mutant&rft.au=Chattopadhyay%2C+Manas+K%3BChen%2C+Weiping%3BPoy%2C+George%3BCam%2C+Margaret%3BStiles%2C+David%3BTabor%2C+Herbert&rft.aulast=Chattopadhyay&rft.aufirst=Manas&rft.date=2009-10-01&rft.volume=26&rft.issue=10&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Yeast&rft.issn=0749503X&rft_id=info:doi/10.1002%2Fyea.1703 L2 - http://www3.interscience.wiley.com/journal/122547016/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Spermine; Arginine; Lysine; Stress; Cell culture; Methionine; Supplementation; Spermidine synthase; Cell division; nucleic acids; Putrescine; Spermidine; NAD; polyamines; Biotin; Metabolism; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1002/yea.1703 ER - TY - JOUR T1 - Implicit reference-based group-wise image registration and its application to structural and functional MRI AN - 746079627; 12978543 AB - In this study, an implicit reference group-wise (IRG) registration with a small deformation, linear elastic model was used to jointly estimate correspondences between a set of MRI images. The performance of pair-wise and group-wise registration algorithms was evaluated for spatial normalization of structural and functional MRI data. Traditional spatial normalization is accomplished by group-to-reference (G2R) registration in which a group of images are registered pair-wise to a reference image. G2R registration is limited due to bias associated with selecting a reference image. In contrast, implicit reference group-wise (IRG) registration estimates correspondences between a group of images by jointly registering the images to an implicit reference corresponding to the group average. The implicit reference is estimated during IRG registration eliminating the bias associated with selecting a specific reference image. Registration performance was evaluated using segmented T1-weighted magnetic resonance images from the Nonrigid Image Registration Evaluation Project (NIREP), DTI and fMRI images. Implicit reference pair-wise (IRP) registration - a special case of IRG registration for two images - is shown to produce better relative overlap than IRG for pair-wise registration using the same small deformation, linear elastic registration model. However, IRP-G2R registration is shown to have significant transitivity error, i.e., significant inconsistencies between correspondences defined by different pair-wise transformations. In contrast, IRG registration produces consistent correspondence between images in a group at the cost of slightly reduced pair-wise RO accuracy compared to IRP-G2R. IRG spatial normalization of the fractional anisotropy (FA) maps of DTI is shown to have smaller FA variance compared with G2R methods using the same elastic registration model. Analyses of fMRI data sets with sensorimotor and visual tasks show that IRG registration, on average, increases the statistical detectability of brain activation compared to G2R registration. JF - NeuroImage AU - Geng, Xiujuan AU - Christensen, Gary E AU - Gu, Hong AU - Ross, Thomas J AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA, gengx@nida.nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 1341 EP - 1351 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 47 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Transformation KW - sensorimotor system KW - Brain mapping KW - Neuroimaging KW - Data processing KW - Statistics KW - Anisotropy KW - Structure-function relationships KW - Functional magnetic resonance imaging KW - Algorithms KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Implicit+reference-based+group-wise+image+registration+and+its+application+to+structural+and+functional+MRI&rft.au=Geng%2C+Xiujuan%3BChristensen%2C+Gary+E%3BGu%2C+Hong%3BRoss%2C+Thomas+J%3BYang%2C+Yihong&rft.aulast=Geng&rft.aufirst=Xiujuan&rft.date=2009-10-01&rft.volume=47&rft.issue=4&rft.spage=1341&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.04.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Transformation; Brain mapping; sensorimotor system; Neuroimaging; Anisotropy; Statistics; Data processing; Structure-function relationships; Functional magnetic resonance imaging; Algorithms DO - http://dx.doi.org/10.1016/j.neuroimage.2009.04.024 ER - TY - JOUR T1 - Hemodynamic nonlinearities affect BOLD fMRI response timing and amplitude AN - 746079007; 12978572 AB - The interpretation of functional magnetic resonance imaging (fMRI) studies based on blood oxygen-level dependent (BOLD) contrast generally relies on the assumption of a linear relationship between evoked neuronal activity and fMRI response. While nonlinearities in this relationship have been suggested by a number of studies, it remains unclear to what extent they relate to the neurovascular response and are therefore inherent to BOLD fMRI. Full characterization of potential vascular nonlinearities is required for accurate inferences about the neuronal system under study. To investigate the extent of vascular nonlinearities, evoked activity was studied in humans with BOLD fMRI (n = 28) and magnetoencephalography (MEG) (n = 5). Brief (600-800 ms) rapidly repeated (1 Hz) visual stimuli were delivered using a stimulation paradigm that minimized neuronal nonlinearities. Nevertheless, BOLD fMRI experiments showed substantial remaining nonlinearities. The smallest stimulus separation (200-400 ms) resulted in significant response broadening (15-20% amplitude decrease; 10-12% latency increase; 6-14% duration increase) with respect to a linear prediction. The substantial slowing and widening of the response in the presence of preceding stimuli suggest a vascular rather than neuronal origin to the observed nonlinearity. This was confirmed by the MEG data, which showed no significant neuro-electric nonlinear interactions between stimuli as little as 200 ms apart. The presence of substantial vascular nonlinearities has important implications for rapid event-related studies by fMRI and other imaging modalities that infer neuronal activity from hemodynamic parameters. JF - NeuroImage AU - De Zwart, Jacco A AU - Van Gelderen, Peter AU - Jansma, JMartijn AU - Fukunaga, Masaki AU - Bianciardi, Marta AU - Duyn, Jeff H AD - Advanced MRI Section, LFMI, NINDS, NIH National Institutes of Health, Bethesda, MD, USA, Jacco.deZwart@nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 1649 EP - 1658 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 47 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Visual stimuli KW - Magnetoencephalography KW - Neuroimaging KW - Data processing KW - Functional magnetic resonance imaging KW - Hemodynamics KW - nonlinear systems KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Hemodynamic+nonlinearities+affect+BOLD+fMRI+response+timing+and+amplitude&rft.au=De+Zwart%2C+Jacco+A%3BVan+Gelderen%2C+Peter%3BJansma%2C+JMartijn%3BFukunaga%2C+Masaki%3BBianciardi%2C+Marta%3BDuyn%2C+Jeff+H&rft.aulast=De+Zwart&rft.aufirst=Jacco&rft.date=2009-10-01&rft.volume=47&rft.issue=4&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Visual stimuli; Magnetoencephalography; Neuroimaging; Data processing; Functional magnetic resonance imaging; Hemodynamics; nonlinear systems DO - http://dx.doi.org/10.1016/j.neuroimage.2009.06.001 ER - TY - JOUR T1 - In vivo diffusion tensor imaging of the human optic chiasm at sub-millimeter resolution AN - 746077966; 12978534 AB - In this work we report findings from an in vivo diffusion tensor imaging (DTI) study of the human optic chiasm at sub-millimeter voxel resolution. Data were collected at 3 T using a diffusion-weighted radial-FSE sequence, which provides images free from typical magnetic susceptibility artifacts. The general DTI features observed in the optic chiasm region were consistent across subjects. They included a central area with high anisotropy and highest diffusivity in a predominately right/left direction corresponding to the decussation of nasal hemiretinae fibers, surrounded by a band of low anisotropy reflecting heterogeneous orientation of fibers within the voxel, and a lateral area with high anisotropy and highest diffusivity in a predominately anterior/posterior direction corresponding to temporal hemiretinae fibers that do not cross. Animal studies indicate that there is a significant dorsal-ventral reorganization of the retinotopic distribution of fibers along the optic pathways. We found that diffusion ellipsoids in the central portion of the optic chiasm show considerable planar anisotropy in the coronal plane indicating fiber crossings in the superior/inferior direction, rather than strictly right/left. This architectural feature of the chiasm suggests that dorso-ventral reorganization of fibers in the optic pathways also occurs in humans. We have shown that by collecting sub-millimeter resolution data, DTI can be used to investigate fine details of small and complex white matter structures, in vivo, with a clinical scanner. High spatial resolution, however, is necessary in the slice direction as well as in-plane to reduce the CSF contribution to the signal and to increase fiber coherence within voxels. JF - NeuroImage AU - Sarlls, Joelle E AU - Pierpaoli, Carlo AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, sarllsjo@mail.nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 1244 EP - 1251 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 47 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Data processing KW - Anisotropy KW - Retina KW - Colony-stimulating factor KW - Magnetic resonance imaging KW - Magnetic susceptibility KW - Substantia alba KW - spatial discrimination KW - Optic chiasm KW - Visual pathways KW - Fibers KW - Diffusion KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746077966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=In+vivo+diffusion+tensor+imaging+of+the+human+optic+chiasm+at+sub-millimeter+resolution&rft.au=Sarlls%2C+Joelle+E%3BPierpaoli%2C+Carlo&rft.aulast=Sarlls&rft.aufirst=Joelle&rft.date=2009-10-01&rft.volume=47&rft.issue=4&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.05.098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Anisotropy; Data processing; Retina; Colony-stimulating factor; Magnetic resonance imaging; Substantia alba; Magnetic susceptibility; spatial discrimination; Optic chiasm; Fibers; Visual pathways; Diffusion DO - http://dx.doi.org/10.1016/j.neuroimage.2009.05.098 ER - TY - JOUR T1 - Centrosome structure and function under normal and pathological conditions AN - 744704460; 13159337 AB - Abstract not available. JF - Environmental and Molecular Mutagenesis AU - Sackett, Dan L AU - Olivero, Ofelia AD - Laboratory of Integrative and Medical Biophysics, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child, Health and Human Development, Bethesda, Maryland Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 591 EP - 592 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 8 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts KW - Structure-function relationships KW - Centrosomes KW - Mutagenesis KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744704460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Centrosome+structure+and+function+under+normal+and+pathological+conditions&rft.au=Sackett%2C+Dan+L%3BOlivero%2C+Ofelia&rft.aulast=Sackett&rft.aufirst=Dan&rft.date=2009-10-01&rft.volume=50&rft.issue=8&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20535 L2 - http://www3.interscience.wiley.com/journal/122604539/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Structure-function relationships; Centrosomes; Mutagenesis DO - http://dx.doi.org/10.1002/em.20535 ER - TY - JOUR T1 - Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma AN - 744703789; 12669648 AB - Objective: Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other. Methods: Genotyping of tag single nucleotide polymorphisms (SNPs) in the IRF4 gene was conducted in 990 NHL cases and 828 controls from a multi-center US study. Measures of sun sensitivity and exposure were ascertained from computer-assisted personal interviews. We used logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI) for NHL in relation to sun exposures, sun exposures in relation to IRF4 genotypes, and NHL in relation to sun exposures. We further assessed the effects of sun exposures in relation to IRF4 genotypes. Results: As previously reported, we found significant associations between IRF4 rs12211228 and NHL and between hair and eye color and NHL. The IRF4 rs12203592 polymorphism (CT/TT genotype) was statistically significantly associated with eye color and particularly with hair color (OR sub(Light Blonde)=0.24, 95% CI=0.11-0.50, overall Chi square p=0.0002). Analysis of joint effects between eye and hair color with the IRF4 rs12203592 SNP did not reveal statistically significant p-interactions although NHL risk did decline with lighter hair color and presence of the variant IRF4 rs12203592 allele, compared to those without a variant allele and with black/brown hair color. Conclusions: Our data do not statistically support a joint effect between IRF4 and sun sensitivity in mediating risk for NHL. Further evaluation of joint effects in other and larger populations is warranted. JF - Cancer Causes & Control AU - Gathany, Allison H AU - Hartge, Patricia AU - Davis, Scott AU - Cerhan, James R AU - Severson, Richard K AU - Cozen, Wendy AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., EPS 7070, Rockville, MD, 20852, USA, wangso@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1291 EP - 1302 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 8 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Sensitivity KW - Pigmentation KW - Data processing KW - Eye KW - Interferon regulatory factor 4 KW - Gene polymorphism KW - Genotyping KW - Statistical analysis KW - Genotypes KW - Hair KW - sun KW - Cancer KW - Color KW - Single-nucleotide polymorphism KW - Sun KW - Lymphoma KW - G 07720:Immunogenetics KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744703789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Relationship+between+interferon+regulatory+factor+4+genetic+polymorphisms%2C+measures+of+sun+sensitivity+and+risk+for+non-Hodgkin+lymphoma&rft.au=Gathany%2C+Allison+H%3BHartge%2C+Patricia%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BCozen%2C+Wendy%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BWang%2C+Sophia+S&rft.aulast=Gathany&rft.aufirst=Allison&rft.date=2009-10-01&rft.volume=20&rft.issue=8&rft.spage=1291&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9348-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Pigmentation; Data processing; Eye; Single-nucleotide polymorphism; Genotyping; Gene polymorphism; Interferon regulatory factor 4; Sun; Statistical analysis; Lymphoma; Hair; Color; non-Hodgkin's lymphoma; Sensitivity; Genotypes; Cancer; sun DO - http://dx.doi.org/10.1007/s10552-009-9348-5 ER - TY - JOUR T1 - Family cancer history affecting risk of colorectal cancer in a prospective cohort of Chinese women AN - 744611093; 12669652 AB - An elevated risk of colorectal cancer has been associated with sporadic colorectal cancer in first-degree relatives, mostly in Western populations. Limited data exist from traditionally low-risk areas, such as Asia, where the prevalence of risk factors may differ. We examined the association of family history of cancer and subsequent colorectal cancer risk in a cohort of traditionally low-risk Chinese women. We followed 73,358 women in the Shanghai Women's Health Study for cancer incidence until December 2005. After an average of 7years of follow-up, 391 women were diagnosed with colorectal cancer. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards models adjusted for age, smoking, family income, education, body mass index, physical activity, and history of diabetes. We observed a significant association between colorectal cancer risk and history of a parent being diagnosed with colorectal cancer (hazard ratio: 3.34; 95% confidence interval: 1.58, 7.06). No association was observed for colorectal cancer diagnosed among siblings. Colorectal cancer risk was not influenced by a positive family history of cancer generally or any of the other cancers investigated (lung, breast, prostate, gastric, esophageal, endometrial, ovarian, urinary tract, central nervous system, and small bowel). Our cohort results suggest that consistent with findings from Western populations, having a family history of colorectal cancer may influence colorectal cancer risk to a similar extent in a low-risk population. JF - Cancer Causes & Control AU - Murphy, Gwen AU - Shu, Xiao-Ou AU - Gao, Yu-Tang AU - Ji, Bu-Tian AU - Cook, Michael Blaise AU - Yang, Gong AU - Li, Hong Lan AU - Rothman, Nathaniel AU - Zheng, Wei AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA, murphygw@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1517 EP - 1521 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 8 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Central nervous system KW - Historical account KW - Age KW - siblings KW - Cancer KW - Genetics KW - Smoking KW - diabetes mellitus KW - Education KW - Lung KW - body mass KW - Urine KW - colorectal carcinoma KW - income KW - China, People's Rep., Shanghai KW - Females KW - Asia KW - physical activity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744611093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Family+cancer+history+affecting+risk+of+colorectal+cancer+in+a+prospective+cohort+of+Chinese+women&rft.au=Murphy%2C+Gwen%3BShu%2C+Xiao-Ou%3BGao%2C+Yu-Tang%3BJi%2C+Bu-Tian%3BCook%2C+Michael+Blaise%3BYang%2C+Gong%3BLi%2C+Hong+Lan%3BRothman%2C+Nathaniel%3BZheng%2C+Wei%3BChow%2C+Wong-Ho&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2009-10-01&rft.volume=20&rft.issue=8&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9353-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Historical account; Central nervous system; Age; siblings; Cancer; Smoking; Genetics; Education; diabetes mellitus; colorectal carcinoma; Urine; body mass; Lung; income; Females; physical activity; China, People's Rep., Shanghai; Asia DO - http://dx.doi.org/10.1007/s10552-009-9353-8 ER - TY - JOUR T1 - Adiposity in relation to colorectal adenomas and hyperplastic polyps in women AN - 744610742; 12669646 AB - Objective: To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps. Methods: We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps. Results: We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women=1.57; 95% CI=1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR=3.76; 95% CI=2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR=2.84; 95% CI=1.41-5.72). Conclusions: Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer. JF - Cancer Causes & Control AU - Leitzmann, Michael F AU - Flood, Andrew AU - Ferrucci, Leah M AU - Schoenfeld, Philip AU - Cash, Brooks AU - Schatzkin, Arthur AU - Cross, Amanda J AD - The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD, 20892, USA, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1497 EP - 1507 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 8 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - polyps KW - colorectal carcinoma KW - body mass KW - obesity KW - Females KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744610742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Adiposity+in+relation+to+colorectal+adenomas+and+hyperplastic+polyps+in+women&rft.au=Leitzmann%2C+Michael+F%3BFlood%2C+Andrew%3BFerrucci%2C+Leah+M%3BSchoenfeld%2C+Philip%3BCash%2C+Brooks%3BSchatzkin%2C+Arthur%3BCross%2C+Amanda+J&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2009-10-01&rft.volume=20&rft.issue=8&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9346-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - polyps; body mass; colorectal carcinoma; obesity; Females; Cancer DO - http://dx.doi.org/10.1007/s10552-009-9346-7 ER - TY - JOUR T1 - Five-factor model personality traits, spirituality/religiousness, and mental health among people living with HIV AN - 743805386; 3957065 AB - We examined the association between five-factor personality domains and facets and spirituality/religiousness as well as their joint association with mental health in a diverse sample of people living with HIV (n = 112, age range 18-66). Spirituality/religiousness showed stronger associations with Conscientiousness, Openness, and Agreeableness than with Neuroticism and Extraversion. Both personality traits and spirituality/religiousness were significantly linked to mental health, even after controlling for individual differences in demographic measures and disease status. Personality traits explained unique variance in mental health above spirituality and religiousness. Further, aspects of spirituality and religiousnes were found to mediate some of the links between personality and mental health in this patient sample. These findings suggest that underlying personality traits contribute to the beneficial effects of spirituality/religiousness among vulnerable populations. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Löckenhoff, Corinna E AU - Ironson, Gail H AU - O'Cleirigh, Conall AU - Costa, Jr., Paul T. AD - National Institute on Aging ; University of Miami ; Harvard University Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1411 EP - 1436 VL - 77 IS - 5 SN - 0022-3506, 0022-3506 KW - Sociology KW - Personality traits KW - Personality KW - Spirituality KW - Mental health KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743805386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Five-factor+model+personality+traits%2C+spirituality%2Freligiousness%2C+and+mental+health+among+people+living+with+HIV&rft.au=L%C3%B6ckenhoff%2C+Corinna+E%3BIronson%2C+Gail+H%3BO%27Cleirigh%2C+Conall%3BCosta%2C+Jr.%2C+Paul+T.&rft.aulast=L%C3%B6ckenhoff&rft.aufirst=Corinna&rft.date=2009-10-01&rft.volume=77&rft.issue=5&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2009.00587.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9429 9416 2153; 7947 5772 7954; 5703 3617 6220; 12127 10784 10766 12024 10762; 9416 2153 DO - http://dx.doi.org/10.1111/j.1467-6494.2009.00587.x ER - TY - JOUR T1 - Regulation of cell fate and patterning in the developing mammalian cochlea. AN - 742787190; pmid-19623076 AB - PURPOSE OF REVIEW: A significant proportion of hearing loss and deafness is caused by defects in the structure or function of cells within the organ of Corti. Identification of the molecular factors that regulate the development of this structure should provide valuable insights regarding inner ear formation and the signaling pathways that underlie congenital auditory deficits. In addition, targeted modulation of these same factors could be developed as therapies for hair cell regeneration. RECENT FINDINGS: Results from experiments using transgenic and mutant mice, as well as in-vitro techniques, have identified genes and signaling pathways that are required to either specify unique auditory cell types, such as hair cells or supporting cells, or to generate the highly ordered cellular pattern that is characteristic for the organ of Corti. In particular, the hedgehog and fibroblast growth factor signaling pathways modulate the formation of the progenitor cells that will give rise to the organ of Corti. SRY-box containing gene 2, a transcription factor that is required for the formation of the cochlear progenitor cell population, has paradoxically been shown to also act as an inhibitor of hair cell development. Finally, the motor protein myosin II regulates extension of the organ of Corti and the alignment of hair cells and supporting cells into ordered rows. SUMMARY: A better understanding of the signaling pathways that direct different aspects of cochlear development, such as specific of cell fates or cellular patterning, offers the potential to identify new pathways or molecules that could be targeted for therapeutic interventions. JF - Current opinion in otolaryngology & head and neck surgery AU - Kelley, Matthew W AU - Driver, Elizabeth C AU - Puligilla, Chandrakala AD - Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA. kelleymt@nidcd.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 381 EP - 387 VL - 17 IS - 5 SN - 1068-9508, 1068-9508 KW - Index Medicus KW - National Library of Medicine KW - Signal Transduction -- physiology KW - Animals KW - Cell Differentiation -- physiology KW - Basic Helix-Loop-Helix Transcription Factors -- physiology KW - Myosin Type II -- physiology KW - Hedgehog Proteins -- physiology KW - Fibroblast Growth Factors -- physiology KW - Mice KW - SOXB1 Transcription Factors -- physiology KW - Mice, Transgenic KW - Pallister-Hall Syndrome -- genetics KW - Organ of Corti -- embryology KW - Organ of Corti -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.atitle=Regulation+of+cell+fate+and+patterning+in+the+developing+mammalian+cochlea.&rft.au=Kelley%2C+Matthew+W%3BDriver%2C+Elizabeth+C%3BPuligilla%2C+Chandrakala&rft.aulast=Kelley&rft.aufirst=Matthew&rft.date=2009-10-01&rft.volume=17&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.issn=10689508&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-08 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Scaling of motor cortical excitability during unimanual force generation. AN - 742777898; pmid-19243741 AB - During performance of a unimanual force generation task primary motor cortices (M1s) experience clear functional changes. Here, we evaluated the way in which M1s interact during parametric increases in right wrist flexion force in healthy volunteers. We measured the amplitude and the slope of motor evoked potentials (MEP) recruitment curves to transcranial magnetic stimulation (TMS) in the left and right flexor carpi radialis (FCR) muscles at rest and during 10%, 30% and 70% of maximal wrist flexion force. At rest, no differences were observed in the amplitude and slope of MEP recruitment curves in the left and right FCR muscles. With increasing right wrist flexion force, MEP amplitudes increased in both FCR muscles, with larger amplitudes in the right FCR. We found a significant correlation between the left and right MEP amplitudes across conditions. The slope of right and left FCR MEP recruitment curve was significantly steeper at 70% of force compared to rest and 10% of force. A significant correlation between the slope of left and right FCR MEP amplitudes was found at 70% of force only. Our results indicate a differential scaling of excitability in the corticospinal system controlling right and left FCR muscles at increasing levels of unimanual force generation. Specifically, these data highlights that at strong levels of unimanual force the increases in motor cortical excitability with increasing TMS stimulus intensities follow a similar pattern in both M1s, while at low levels of force they do not. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Perez, Monica A AU - Cohen, Leonardo G AD - Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. perezmo@pitt.edu Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1065 EP - 1071 VL - 45 IS - 9 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Action Potentials -- physiology KW - Analysis of Variance KW - Humans KW - Electromyography KW - Muscle Contraction -- physiology KW - Neural Conduction -- physiology KW - Movement -- physiology KW - Adult KW - Wrist -- physiology KW - Evoked Potentials, Motor -- physiology KW - Transcranial Magnetic Stimulation KW - Male KW - Female KW - Recruitment, Neurophysiological -- physiology KW - Motor Cortex -- physiology KW - Hand Strength -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Scaling+of+motor+cortical+excitability+during+unimanual+force+generation.&rft.au=Perez%2C+Monica+A%3BCohen%2C+Leonardo+G&rft.aulast=Perez&rft.aufirst=Monica&rft.date=2009-10-01&rft.volume=45&rft.issue=9&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood--brain barrier disruption in multiple sclerosis. AN - 734173137; 19776093 AB - Rolipram, a prototypic phosphodiesterase-4 inhibitor, is highly effective in suppressing Th1 autoimmunity in multiple animal models, including experimental autoimmune encephalomyelitis. In addition, rolipram has been extensively studied as a potential neuroprotective agent. Based on its anti-inflammatory activity, we tested the efficacy of rolipram in suppressing inflammatory disease activity in multiple sclerosis in a proof-of-principle phase I/II open-label clinical trial. Enrolled MS patients were evaluated by monthly MRI and clinical examinations during 3 months (four MRIs) of pretreatment baseline and 8 months of rolipram therapy. The primary outcome was a change in contrast-enhanced lesions between baseline and the last 4 months of rolipram therapy. Previously defined biomarkers of rolipram-mediated immunomodulation were evaluated during the study. The trial was stopped prematurely because the drug was poorly tolerated and because of safety concerns: we observed an increase, rather than decrease, in the brain inflammatory activity measured by contrast-enhanced lesions on brain MRI. At the administered doses rolipram was active in vivo as documented by immunological assays. We conclude that the reasons underlying the discrepancy between the therapeutic efficacy of rolipram in experimental autoimmune encephalomyelitis versus multiple sclerosis are at present not clear. JF - Multiple sclerosis (Houndmills, Basingstoke, England) AU - Bielekova, Bibiana AU - Richert, Nancy AU - Howard, Thomas AU - Packer, Amy N AU - Blevins, Gregg AU - Ohayon, Joan AU - McFarland, Henry F AU - Stürzebecher, Claus-Steffen AU - Martin, Roland AD - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1206 EP - 1214 VL - 15 IS - 10 KW - Biomarkers KW - 0 KW - Contrast Media KW - Phosphodiesterase 4 Inhibitors KW - Phosphodiesterase Inhibitors KW - Rolipram KW - K676NL63N7 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Cell Proliferation -- drug effects KW - Treatment Failure KW - Humans KW - Inflammation -- drug therapy KW - Biomarkers -- metabolism KW - T-Lymphocytes -- pathology KW - Time Factors KW - Immunophenotyping KW - Inflammation -- pathology KW - Inflammation -- diagnosis KW - Blood-Brain Barrier -- drug effects KW - Multiple Sclerosis -- metabolism KW - Rolipram -- adverse effects KW - Multiple Sclerosis -- drug therapy KW - Blood-Brain Barrier -- pathology KW - Multiple Sclerosis -- immunology KW - Rolipram -- therapeutic use KW - Multiple Sclerosis -- diagnosis KW - Phosphodiesterase Inhibitors -- therapeutic use KW - Phosphodiesterase Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734173137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Multiple+sclerosis+%28Houndmills%2C+Basingstoke%2C+England%29&rft.atitle=Treatment+with+the+phosphodiesterase+type-4+inhibitor+rolipram+fails+to+inhibit+blood--brain+barrier+disruption+in+multiple+sclerosis.&rft.au=Bielekova%2C+Bibiana%3BRichert%2C+Nancy%3BHoward%2C+Thomas%3BPacker%2C+Amy+N%3BBlevins%2C+Gregg%3BOhayon%2C+Joan%3BMcFarland%2C+Henry+F%3BSt%C3%BCrzebecher%2C+Claus-Steffen%3BMartin%2C+Roland&rft.aulast=Bielekova&rft.aufirst=Bibiana&rft.date=2009-10-01&rft.volume=15&rft.issue=10&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=Multiple+sclerosis+%28Houndmills%2C+Basingstoke%2C+England%29&rft.issn=1477-0970&rft_id=info:doi/10.1177%2F1352458509345903 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Diabetes. 1998 Apr;47(4):570-5 [9568689] J Immunol. 1997 Dec 15;159(12):6253-9 [9550429] J Neuroimmunol. 1999 Mar 1;95(1-2):35-42 [10229113] Brain. 1999 May;122 ( Pt 5):871-82 [10355672] J Neuroimmunol. 1999 Jun 1;97(1-2):119-28 [10408965] J Neuroimmunol. 1999 Aug 3;98(2):147-56 [10430048] Neurology. 2006 Feb 28;66(4):551-6 [16505310] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6 [16585503] Crit Rev Immunol. 2006;26(2):113-31 [16700649] J Pharmacol Exp Ther. 2006 Oct;319(1):63-72 [16809479] J Clin Invest. 2006 Dec;116(12):3252-7 [17099776] Curr Opin Investig Drugs. 2007 May;8(5):364-72 [17520865] Exp Neurol. 2008 May;211(1):311-4 [18328479] Neurobiol Dis. 2008 Jun;30(3):375-87 [18424161] J Immunol. 2000 Jan 15;164(2):1117-24 [10623864] Nat Med. 2000 Oct;6(10):1167-75 [11017150] J Neuroimmunol. 2000 Nov 1;111(1-2):186-94 [11063837] Neuroreport. 2001 May 25;12(7):1507-11 [11388438] Ann Neurol. 2001 Jul;50(1):121-7 [11456302] Mult Scler. 2002 Feb;8(1):24-9 [11936485] J Exp Med. 2004 Apr 5;199(7):971-9 [15067033] Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8705-8 [15161974] Neurology. 1983 Nov;33(11):1444-52 [6685237] J Comput Assist Tomogr. 1992 Mar-Apr;16(2):274-84 [1545026] Eur J Immunol. 1993 Aug;23(8):1745-51 [8393796] Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3601-5 [7536938] Ann Neurol. 1995 May;37(5):611-9 [7755356] Nat Med. 1995 Mar;1(3):244-8 [7585041] J Neuroimmunol. 1996 Aug;68(1-2):1-11 [8784254] J Neurol Sci. 1996 Jan;135(1):1-9 [8926489] J Mol Med (Berl). 1997 Feb;75(2):95-102 [9083927] J Magn Reson Imaging. 1997 Mar-Apr;7(2):410-5 [9090600] Clin Exp Immunol. 1997 Jun;108(3):415-9 [9182885] Trends Pharmacol Sci. 1997 May;18(5):164-71 [9184477] J Immunol. 1997 Aug 1;159(3):1520-9 [9233651] Neurology. 1997 Sep;49(3):862-9 [9305355] J Neuroimmunol. 1997 Oct;79(1):54-61 [9357447] Invest Ophthalmol Vis Sci. 1999 Apr;40(5):942-50 [10102291] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1352458509345903 ER - TY - JOUR T1 - Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. AN - 734168721; 19363674 AB - Isothiocyanates have potential chemopreventive and antitumor effects. In the present study, we examined the actions of PEITC and sulphoraphane in modulating the activity of protein kinase C (PKC) and telomerase in cervical cancer cell line HeLa. These tumor markers are highly activated in human cancers. These compound efficiently downregulated the antiapoptotic isoforms (PKC-alpha, -betaII, -epsilon, and -zeta) as well as telomerase, whereas the proapoptotic form (PKC-delta) was upregulated. Studies were performed to measure the degree of apoptotic cell death induced by either isothiocyanates alone, or in combination with adriamycin or etoposide. Apoptosis was evident from mitochondrial cytochrome c release, apoptotic index and caspases 3 and 8 activation. Results showed that pretreatment exhibited better efficacy in sensitizing HeLa cells toward apoptosis by modulating PKCs, telomerase. This effect of isothiocyanates might prove to be of considerable value in synergistic therapy of cancer such that the drug dose level could be minimized. JF - Molecular and cellular biochemistry AU - Mukherjee, Sutapa AU - Dey, Shubhabrata AU - Bhattacharya, R K AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700 026, India. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 9 EP - 22 VL - 330 IS - 1-2 KW - Isothiocyanates KW - 0 KW - sulphoraphene KW - Etoposide KW - 6PLQ3CP4P3 KW - phenethyl isothiocyanate KW - 6U7TFK75KV KW - Doxorubicin KW - 80168379AG KW - Protein Kinase C KW - EC 2.7.11.13 KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Uterine Cervical Neoplasms KW - Etoposide -- pharmacology KW - Doxorubicin -- pharmacology KW - HeLa Cells KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - Apoptosis -- drug effects KW - Drug Synergism KW - Female KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- drug effects KW - Isothiocyanates -- pharmacology KW - Telomerase -- drug effects KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Telomerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734168721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Isothiocyanates+sensitize+the+effect+of+chemotherapeutic+drugs+via+modulation+of+protein+kinase+C+and+telomerase+in+cervical+cancer+cells.&rft.au=Mukherjee%2C+Sutapa%3BDey%2C+Shubhabrata%3BBhattacharya%2C+R+K%3BRoy%2C+Madhumita&rft.aulast=Mukherjee&rft.aufirst=Sutapa&rft.date=2009-10-01&rft.volume=330&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=1573-4919&rft_id=info:doi/10.1007%2Fs11010-009-0095-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-02 N1 - Date created - 2009-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11010-009-0095-4 ER - TY - JOUR T1 - Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics. AN - 734136759; 19906229 AB - Clinicians have long known that a substantial proportion of patients treated with high-dose glucocorticoids experience a variety of serious side effects, including metabolic syndrome, bone loss, and mood shifts, such as depressive symptomatology, manic or hypomanic symptoms, and even suicide. The reason for individual variability in expression or severity of these side effects is not clear. However, recent emerging literature is beginning to shed light on possible mechanisms of these effects. As an introduction to this volume, this chapter will review the basic biology of glucocorticoid release and molecular mechanisms of glucocorticoid receptor function, and will discuss how dysregulation of glucocorticoid action at all levels could contribute to such side effects. At the molecular level, glucocorticoid receptor polymorphisms may be associated either with receptor hypofunction or hyperfunction and could thus contribute to differential individual sensitivity to the effects of glucocorticoid treatment. Numerous factors regulate hypothalamic-pituitary-adrenal (HPA) axis responsiveness, which could also contribute to individual differences in glucocorticoid side effects. One of these is sex hormone status and the influence of estrogen and progesterone on HPA axis function and mood. Another is immune system activity, in which immune molecules, such as interleukins and cytokines, activate the HPA axis and alter brain function, including memory, cognition, and mood. The effects of cytokines in inducing sickness behaviors, which overlap with depressive symptomatology, could also contribute to individual differences in such symptomatology. Taken together, this knowledge will have important relevance for identifying at-risk patients to avoid or minimize such side effects when they are treated with glucocorticoids. A framework for assessment of patients is proposed that incorporates functional, physiological, and molecular biomarkers to identify subgroups of patients at risk for depressive symptomatology associated with glucocorticoid treatment, and for prevention of side effects, which in many cases can be life-threatening. JF - Annals of the New York Academy of Sciences AU - Marques, Andrea H AU - Silverman, Marni N AU - Sternberg, Esther M AD - Section on Neuroendocrine Immunology and Behavior, Integrative Neural Immune Program, National Institute of Mental Health, National Institutes of Health, Rockville, Maryland, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1 EP - 18 VL - 1179 KW - Glucocorticoids KW - 0 KW - Gonadal Steroid Hormones KW - Receptors, Glucocorticoid KW - Index Medicus KW - Animals KW - Gonadal Steroid Hormones -- pharmacology KW - Depressive Disorder -- chemically induced KW - Receptors, Glucocorticoid -- antagonists & inhibitors KW - Receptors, Glucocorticoid -- agonists KW - Humans KW - Depressive Disorder -- physiopathology KW - Depressive Disorder -- pathology KW - Forecasting KW - Cognition Disorders -- chemically induced KW - Cognition Disorders -- physiopathology KW - Hypothalamo-Hypophyseal System -- physiology KW - Hypothalamo-Hypophyseal System -- drug effects KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Pituitary-Adrenal System -- physiopathology KW - Pituitary-Adrenal System -- drug effects KW - Pituitary-Adrenal System -- physiology KW - Glucocorticoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734136759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Glucocorticoid+dysregulations+and+their+clinical+correlates.+From+receptors+to+therapeutics.&rft.au=Marques%2C+Andrea+H%3BSilverman%2C+Marni+N%3BSternberg%2C+Esther+M&rft.aulast=Marques&rft.aufirst=Andrea&rft.date=2009-10-01&rft.volume=1179&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.04987.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-02 N1 - Date created - 2009-11-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biol Psychiatry. 2001 Mar 1;49(5):391-404 [11274650] 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Acad Sci. 2004 Dec;1032:191-4 [15677408] Compr Psychiatry. 2005 Mar-Apr;46(2):155-8 [15723034] Biol Psychiatry. 2005 Mar 1;57(5):543-8 [15737670] Mol Psychiatry. 2005 Mar;10(3):239-50 [15685252] Mol Psychiatry. 2005 Apr;10(4):332-3 [15655564] Viral Immunol. 2005;18(1):41-78 [15802953] Endocrinol Metab Clin North Am. 2005 Jun;34(2):271-92, vii [15850842] Stress. 2004 Dec;7(4):209-19 [16019586] J Affect Disord. 2005 Aug;87(2-3):305-11 [15951024] Psychosom Med. 2005 Sep-Oct;67(5):679-87 [16204423] N Engl J Med. 2005 Oct 20;353(16):1711-23 [16236742] Trends Endocrinol Metab. 2005 Dec;16(10):445-50 [16275120] Psychoneuroendocrinology. 2006 Jan;31(1):1-15 [15950391] Trends Immunol. 2006 Jan;27(1):24-31 [16316783] Clin Pharmacol Ther. 1972 Sep-Oct;13(5):694-8 [5053810] Clin Exp Dermatol. 1976 Dec;1(4):337-42 [793745] J Clin Endocrinol Metab. 1981 Jul;53(1):69-75 [7195405] J Clin Endocrinol Metab. 1982 Feb;54(2):332-42 [6274900] Am J Dis Child. 1982 Mar;136(3):274-5 [7064956] J Affect Disord. 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[12025720] J Psychiatr Res. 2002 Sep-Oct;36(5):287-97 [12127596] Biol Psychiatry. 2002 Sep 1;52(5):386-92 [12242054] J Psychosom Res. 2002 Oct;53(4):873-6 [12377296] Brain Behav Immun. 2002 Oct;16(5):575-80 [12401471] Psychoneuroendocrinology. 2003 Jan;28(1):49-65 [12445836] J Psychiatr Res. 2003 Jan-Feb;37(1):85-7 [12482473] Curr Opin Investig Drugs. 2003 Jan;4(1):46-50 [12625028] Psychoneuroendocrinology. 2003 Jul;28(5):687-701 [12727135] J Clin Endocrinol Metab. 2003 Jul;88(7):3057-63 [12843143] Br J Pharmacol. 2003 Jul;139(6):1111-8 [12871829] Am J Psychiatry. 2003 Sep;160(9):1554-65 [12944327] Brain Behav Immun. 2003 Oct;17(5):350-64 [12946657] Am J Psychiatry. 2003 Oct;160(10):1842-6 [14514500] Clin Endocrinol (Oxf). 2003 Nov;59(5):585-92 [14616881] Recent Prog Horm Res. 2004;59:333-57 [14749509] J Neurosci. 2004 Feb 11;24(6):1478-85 [14960621] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1749-6632.2009.04987.x ER - TY - JOUR T1 - Implications of plasma Delta9-tetrahydrocannabinol, 11-hydroxy-THC, and 11-nor-9-carboxy-THC concentrations in chronic cannabis smokers. AN - 734116440; 19874654 AB - Delta(9)-Tetrahydrocannabinol (THC) is commonly found in toxicological specimens from driving under the influence and accident investigations. Plasma cannabinoid concentrations were determined in 18 long-term heavy cannabis smokers residing on an in-patient research unit for seven days of monitored abstinence. THC, 11-hydroxy-THC, and 11-nor-9-carboxy-THC (THCCOOH) were quantified by two-dimensional gas chromatography-mass spectrometry with cryofocusing. THC concentrations were > 1 ng/mL in nine (50.0%) participants (1.2-5.5 ng/mL) on abstinence day 7. THCCOOH was detected (2.8-45.6 ng/mL) in all participants on study day 7. THC and THCCOOH median percent concentration decreases (n = 18) were 39.5% and 72.9% from day 1 to 7, respectively. Most (88.9%) of the participants had at least one specimen with increased THC compared to the previous day. Cannabis use duration and plasma THCCOOH concentrations were positively correlated on days 1-3 (R = 0.584-0.610; p = 0.007-0.011). There were no significant correlations between THC concentrations > 0.25 ng/mL and body mass index on days 1-7 (R = -0.234-0.092; p = 0.350-0.766). Measurable THC concentrations after seven days of abstinence indicate a potential mechanism for residual neurocognitive impairment observed in chronic cannabis users. THC's presence in plasma for seven days of abstinence suggests its detection may not indicate recent use in daily cannabis users. JF - Journal of analytical toxicology AU - Karschner, Erin L AU - Schwilke, Eugene W AU - Lowe, Ross H AU - Darwin, W David AU - Herning, Ronald I AU - Cadet, Jean Lud AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 469 EP - 477 VL - 33 IS - 8 KW - Biomarkers KW - 0 KW - 11-hydroxy-delta(9)-tetrahydrocannabinol KW - 26108-40-7 KW - 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid KW - 4TPC9E4A32 KW - Dronabinol KW - 7J8897W37S KW - delta(9)-tetrahydrocannabinolic acid KW - EJ6CZV0K5Y KW - Index Medicus KW - Marijuana Smoking -- blood KW - Cognition Disorders -- diagnosis KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Cognition Disorders -- chemically induced KW - Biomarkers -- blood KW - Cognition Disorders -- blood KW - Dronabinol -- analogs & derivatives KW - Dronabinol -- pharmacokinetics KW - Substance-Related Disorders -- blood KW - Dronabinol -- blood KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734116440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Implications+of+plasma+Delta9-tetrahydrocannabinol%2C+11-hydroxy-THC%2C+and+11-nor-9-carboxy-THC+concentrations+in+chronic+cannabis+smokers.&rft.au=Karschner%2C+Erin+L%3BSchwilke%2C+Eugene+W%3BLowe%2C+Ross+H%3BDarwin%2C+W+David%3BHerning%2C+Ronald+I%3BCadet%2C+Jean+Lud%3BHuestis%2C+Marilyn+A&rft.aulast=Karschner&rft.aufirst=Erin&rft.date=2009-10-01&rft.volume=33&rft.issue=8&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-10-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Forensic Sci. 2000 Jan;45(1):24-30 [10641915] Psychopharmacology (Berl). 1993;110(1-2):219-28 [7870889] Drug Alcohol Depend. 2009 Nov 1;105(1-2):24-32 [19631478] Clin Chem. 2009 Jun;55(6):1188-95 [19264857] Am J Addict. 2009 Jan-Feb;18(1):53-64 [19219666] J Anal Toxicol. 2008 Mar;32(2):160-4 [18334100] Addiction. 2008 Mar;103(3):452-61 [18190663] Exp Clin Psychopharmacol. 2008 Feb;16(1):22-32 [18266549] Addiction. 2007 Dec;102(12):1910-7 [17916224] J Anal Toxicol. 2007 Oct;31(8):477-85 [17988462] J Chromatogr A. 2007 Sep 7;1163(1-2):318-27 [17640656] Drug Alcohol Depend. 2006 Nov 8;85(2):114-22 [16723194] Psychol Med. 2006 Oct;36(10):1447-60 [16854249] Forensic Sci Int. 2006 Sep 12;161(2-3):169-74 [16859848] Ther Drug Monit. 2006 Aug;28(4):540-4 [16885722] J Anal Toxicol. 2005 Nov-Dec;29(8):842-3 [16356342] Clin Chem. 2005 Dec;51(12):2289-95 [16223887] Forensic Sci Int. 2005 Dec 20;155(2-3):172-8 [16226154] Psychopharmacology (Berl). 2005 Jun;180(1):107-14 [15619106] J Clin Psychiatry. 1999 Jun;60(6):395-9 [10401919] Arch Gen Psychiatry. 1996 Nov;53(11):1051-7 [8911228] JAMA. 1996 Feb 21;275(7):521-7 [8606472] World Health Organ Tech Rep Ser. 1995;854:1-452 [8594834] Life Sci. 1995;56(23-24):2119-26 [7776840] JAMA. 2002 Mar 6;287(9):1123-31 [11879109] Psychopharmacology (Berl). 2002 Oct;164(1):61-70 [12373420] J Clin Pharmacol. 2002 Nov;42(11 Suppl):41S-47S [12412835] Neurology. 2002 Nov 12;59(9):1337-43 [12427880] Accid Anal Prev. 2004 Mar;36(2):239-48 [14642878] Biochem Pharmacol. 1970 Apr;19(4):1333-9 [5513923] Science. 1973 Jan 26;179(4071):391-3 [4682965] J Pharm Sci. 1977 Mar;66(3):395-407 [845807] Clin Pharmacol Ther. 1983 Sep;34(3):352-63 [6309462] J Pharm Pharmacol. 1988 May;40(5):374-5 [2899638] J Anal Toxicol. 1989 Jul-Aug;13(4):218-23 [2550702] J Pharmacol Exp Ther. 1990 Nov;255(2):624-30 [2173751] J Anal Toxicol. 1992 Sep-Oct;16(5):276-82 [1338215] J Anal Toxicol. 1992 Sep-Oct;16(5):283-90 [1338216] Arch Gen Psychiatry. 2001 Oct;58(10):909-15 [11576028] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Packages of care for alcohol use disorders in low- and middle-income countries. AN - 734104406; 19859536 AB - In the fourth in a series of six articles on packages of care for mental disorders in low- and middle-income countries, Vivek Benegal and colleagues discuss the treatment of alcohol use disorders. JF - PLoS medicine AU - Benegal, Vivek AU - Chand, Prabhat K AU - Obot, Isidore S AD - Deaddiction Centre, National Institute of Mental Health and Neurosciences, Bangalore, India. vbenegal@gmail.com Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1 VL - 6 IS - 10 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Humans KW - Developing Countries -- economics KW - Health Care Costs KW - Ethanol -- adverse effects KW - Alcohol-Induced Disorders -- pathology KW - Delivery of Health Care -- trends KW - Alcohol-Induced Disorders -- classification KW - Alcohol-Induced Disorders -- therapy KW - Delivery of Health Care -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734104406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=Packages+of+care+for+alcohol+use+disorders+in+low-+and+middle-income+countries.&rft.au=Benegal%2C+Vivek%3BChand%2C+Prabhat+K%3BObot%2C+Isidore+S&rft.aulast=Benegal&rft.aufirst=Vivek&rft.date=2009-10-01&rft.volume=6&rft.issue=10&rft.spage=e1000170&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/10.1371%2Fjournal.pmed.1000170 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-11 N1 - Date created - 2009-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 2004 Apr;28(4):608-18 [15100612] Addiction. 2004 Jun;99(6):785 [15139877] Addiction. 2004 Jul;99(7):811-28 [15200577] Emerg Med J. 2004 Jul;21(4):491-2 [15208238] Lancet. 2009 Jun 27;373(9682):2247-57 [19560606] PLoS Med. 2009 Oct;6(10):e1000159 [19806179] Biochem Pharmacol. 2008 Jan 1;75(1):34-56 [17880925] Alcohol Alcohol. 2008 Jan-Feb;43(1):53-61 [17965444] J Psychopharmacol. 2008 Jan;22(1):11-23 [18187529] Rev Bras Psiquiatr. 2007 Dec;29(4):315-23 [17713702] Lancet. 2004 Oct 9-15;364(9442):1334-9 [15474136] JAMA. 1984 Oct 12;252(14):1905-7 [6471323] JAMA. 1986 Sep 19;256(11):1449-55 [3528541] N Engl J Med. 1989 Feb 9;320(6):358-65 [2913493] Br J Addict. 1990 Jan;85(1):61-70 [2310855] BMJ. 1991 Sep 28;303(6805):766-9 [1932941] Addiction. 1993 Jun;88(6):791-804 [8329970] CMAJ. 1995 Mar 15;152(6):851-9 [7697578] Alcohol Clin Exp Res. 1996 Nov;20(8):1443-50 [8947323] Arch Gen Psychiatry. 1997 Aug;54(8):737-42 [9283509] Prev Med. 1999 May;28(5):503-9 [10329341] Alcohol Clin Exp Res. 2004 Nov;28(11):1710-7 [15547458] Addiction. 2005 Jan;100(1):70-8 [15598194] Bull World Health Organ. 2004 Nov;82(11):858-66 [15640922] Cochrane Database Syst Rev. 2005;(1):CD001867 [15674887] Health Policy Plan. 2005 Jan;20(1):41-9 [15689429] J Stud Alcohol. 2004 Nov;65(6):782-93 [15700517] Lancet. 2005 Feb 5-11;365(9458):519-30 [15705462] Ir J Med Sci. 2004 Jan-Mar;173(1):34-7 [15732235] JAMA. 2005 Apr 6;293(13):1617-25 [15811981] Arch Intern Med. 2005 May 9;165(9):986-95 [15883236] Cochrane Database Syst Rev. 2005;(3):CD005063 [16034964] Addiction. 2005 Aug;100(8):1051-6 [16042631] Addict Biol. 2005 Sep;10(3):289-92 [16109592] BMJ. 2005 Sep 10;331(7516):544 [16150765] Alcohol Alcohol. 2005 Nov-Dec;40(6):578-83 [16115822] Alcohol Alcohol. 2005 Nov-Dec;40(6):575-7 [16115823] Alcohol Alcohol. 2005 Nov-Dec;40(6):584-9 [16143704] JAMA. 2006 May 3;295(17):2003-17 [16670409] Cochrane Database Syst Rev. 2006;(3):CD005032 [16856072] BMC Fam Pract. 2006;7:48 [16867187] Addiction. 2006 Nov;101(11):1561-8 [17034435] Cochrane Database Syst Rev. 2007;(2):CD004148 [17443541] Biol Psychiatry. 2007 Sep 15;62(6):694-7 [17336941] Alcohol Alcohol. 2007 Jul-Aug;42(4):328-32 [17360720] Perspect Psychiatr Care. 2007 Oct;43(4):183-92 [17894668] Lancet. 2007 Dec 8;370(9603):1915-22 [18068515] Int J Methods Psychiatr Res. 2008 Jun;17 Suppl 1:S50-9 [18543363] Alcohol Alcohol. 2008 Jul-Aug;43(4):470-6 [18364361] Croat Med J. 2008 Jun;49(3):392-401 [18581618] Ann Fam Med. 2008 Sep-Oct;6(5):435-40 [18779548] Alcohol Clin Exp Res. 2009 Jan;33(1):95-101 [18945220] J Stud Alcohol Drugs. 2009 May;70(3):467-74 [19371497] Lancet. 2009 Jun 27;373(9682):2173-4 [19560583] Lancet. 2009 Jun 27;373(9682):2223-33 [19560604] Lancet. 2009 Jun 27;373(9682):2234-46 [19560605] Curr Opin Psychiatry. 2008 May;21(3):229-33 [18382219] J Subst Abuse Treat. 2008 Jun;34(4):460-3 [17629442] J Consult Clin Psychol. 2000 Aug;68(4):573-9 [10965632] J Stud Alcohol. 2001 May;62(3):277-85 [11414336] Alcohol Clin Exp Res. 2001 Sep;25(9):1335-41 [11584154] Alcohol Clin Exp Res. 2002 Apr;26(4):478-84 [11981123] Alcohol Alcohol. 2002 Sep-Oct;37(5):504-8 [12217947] Alcohol Alcohol. 2003 Mar-Apr;38(2):135-41 [12634260] Lancet. 2003 May 17;361(9370):1677-85 [12767733] Eur Addict Res. 2003 Oct;9(4):147-56 [12970583] Alcohol Clin Exp Res. 2003 Oct;27(10):1645-56 [14574236] Alcohol Clin Exp Res. 2004 Jan;28(1):51-63 [14745302] J Psychopharmacol. 2003 Dec;17(4):397-402 [14870951] Ann Intern Med. 2004 Apr 6;140(7):557-68 [15068985] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pmed.1000170 ER - TY - JOUR T1 - The paradox of caffeine-zolpidem interaction: a network analysis. AN - 734104341; 19860644 AB - A widely prescribed and potent short-acting hypnotic, zolpidem has become the mainstay for the treatment of middle-of-the-night sleeplessness. It is expected to be antagonized by caffeine. Paradoxically, in some cases caffeine appears to slightly enhance zolpidem sedation. The pharmacokinetic and pharmacodynamic nature of this odd effect remains unexplored. The purpose of this study is to reproduce a hypothetical molecular network recruited by caffeine when co-administered with zolpidem using Ingenuity Pathway Analysis. Thus generated, network drew attention to several possible contributors to caffeine sedation, such as tachykinin precursor 1, cannabinoid, and GABA receptors. The present overview is centered on the possibility that caffeine potentiation of zolpidem sedation does not involve a centralized interaction of specific neurotransmitters, but rather is contributed by its antioxidant capacity. It is proposed that by modifying the cellular redox state, caffeine ultimately reduces the pool of reactive oxygen species, thereby increasing the bioavailability of endogenous melatonin for interaction with zolpidem. This side effect of caffeine encourages further studies of multiple antioxidants as an attractive way to potentially increasing somnolence. JF - Current drug targets AU - Myslobodsky, Michael AD - Howard University Graduate School (Washington, DC) and Clinical Brain Disorders Branch, NIMH/National Institutes of Health, Bethesda, USA. myslobom@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1009 EP - 1020 VL - 10 IS - 10 KW - Antioxidants KW - 0 KW - Central Nervous System Stimulants KW - Hypnotics and Sedatives KW - Pyridines KW - Reactive Oxygen Species KW - Caffeine KW - 3G6A5W338E KW - zolpidem KW - 7K383OQI23 KW - Melatonin KW - JL5DK93RCL KW - Index Medicus KW - Software KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Antioxidants -- pharmacology KW - Humans KW - Drug Synergism KW - Melatonin -- metabolism KW - Central Nervous System Stimulants -- pharmacology KW - Caffeine -- pharmacology KW - Pyridines -- pharmacology KW - Hypnotics and Sedatives -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734104341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets&rft.atitle=The+paradox+of+caffeine-zolpidem+interaction%3A+a+network+analysis.&rft.au=Myslobodsky%2C+Michael&rft.aulast=Myslobodsky&rft.aufirst=Michael&rft.date=2009-10-01&rft.volume=10&rft.issue=10&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets&rft.issn=1873-5592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of immunocompetent patients with primary central nervous system lymphoma. AN - 734100026; 19858054 AB - Primary central nervous system (CNS) lymphoma (PCNSL) is a non-Hodgkin lymphoma that arises within and is confined to the CNS. Recent data have suggested an increasing incidence in immunocompetent individuals, with a peak of incidence between 60 and 70 years of age. Patients with PCNSL present mostly with symptoms of increased intracranial pressure. The clinical management of these patients remains controversial, and the optimal treatment for patients with PCNSL has not yet been defined. Surgery, even if macroscopically radical, does not improve survival because of the multifocal and infiltrative nature of PCNSL; furthermore, the deep location of most of these tumors makes patients susceptible to serious and irreversible neurologic sequelae. Corticosteroids have a specific role in the treatment of patients with PCNSL, whose disease is sensitive to them as a chemotherapeutic agent. PCNSL is an extremely radiation-sensitive neoplasm; whole-brain radiation therapy plus corticosteroids was the first modality of treatment for patients with this neoplasm until 10 years ago, with a low cure rate and a high local recurrence rate. PCNSL is also a chemosensitive neoplasm; while the optimal choice, sequence, and combination of appropriate agents for efficacious treatment of patients with PCNSL has yet to be determined. An essential component of therapy must include an adequate drug delivery behind a normal blood-brain barrier. Methotrexate is the agent with the most proven activity in PCNSL. Combined-modality therapy has improved survival, but relapse is still common, and late neurologic toxicity is a significant complication, especially in older patients, who represent the majority of immunocompetent patients with PCNSL. JF - Clinical lymphoma & myeloma AU - Chimienti, Emanuela AU - Spina, Michele AU - Vaccher, Emanuela AU - Tirelli, Umberto AD - Division of Medical Oncology, National Cancer Institute, Aviano, Italy. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 353 EP - 364 VL - 9 IS - 5 KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Immunocompetence KW - Lymphoma, Non-Hodgkin -- diagnosis KW - Brain Neoplasms -- pathology KW - Brain Neoplasms -- therapy KW - Lymphoma, Non-Hodgkin -- therapy KW - Brain Neoplasms -- immunology KW - Lymphoma, Non-Hodgkin -- immunology KW - Lymphoma, Non-Hodgkin -- pathology KW - Brain Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734100026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+lymphoma+%26+myeloma&rft.atitle=Management+of+immunocompetent+patients+with+primary+central+nervous+system+lymphoma.&rft.au=Chimienti%2C+Emanuela%3BSpina%2C+Michele%3BVaccher%2C+Emanuela%3BTirelli%2C+Umberto&rft.aulast=Chimienti&rft.aufirst=Emanuela&rft.date=2009-10-01&rft.volume=9&rft.issue=5&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Clinical+lymphoma+%26+myeloma&rft.issn=1938-0712&rft_id=info:doi/10.3816%2FCLM.2009.n.070 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-12 N1 - Date created - 2009-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3816/CLM.2009.n.070 ER - TY - JOUR T1 - Tamoxifen use in Indian women--adverse effects revisited. AN - 734088385; 19827879 AB - Tamoxifen is generally considered a safe drug for Indian women with breast cancer. Indian women seem to tolerate tamoxifen therapy better than western women, but there are no data regarding safety and local adverse effect profiles in typical Indian populations. A total of 3,000 case records of patients who had received tamoxifen daily for any period of time, between January 1988 and December 2007, were identified for study. Hot flashes were reported by 800 (26%), mild vaginal dryness by 450 (15%) and vaginal discharge by 300 (10%), with vaginal bleeding experienced by 40 (1.3%) patients. A total of 1,100 (36.6%) asymptomatic patients had a thickened endometrium(defined as >8mm in thickness) on ultrasonography. Endometrial curettage was performed in all of these. None of the patients developed endometrial carcinoma. Fatty infiltration of liver was found in 1,440 (48%) patients with a mean time interval for development of 7 months (range 6-30 months). Fatty infiltration of liver is found in almost half of the Eastern Indian women who receive tamoxifen. Increased endometrial thickness, which remains asymptomatic, was documented in more than one third of patients on ultrasound examination. Tamoxifen seems to have a negligible potential for causation of uterine malignancies in eastern Indian women. Rates of hysterectomies in Indian patients on tamoxifen are substantially lower than those of western patients on tamoxifen. JF - Asian Pacific journal of cancer prevention : APJCP AU - Ashraf, M AU - Biswas, J AU - Majumdar, S AU - Nayak, S AU - Alam, N AU - Mukherjee, K K AU - Gupta, S AD - Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, India. ashraf_qz@yahoo.co.in PY - 2009 SP - 609 EP - 612 VL - 10 IS - 4 SN - 1513-7368, 1513-7368 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Tamoxifen KW - 094ZI81Y45 KW - Index Medicus KW - India -- epidemiology KW - Survival Rate KW - Humans KW - Adult KW - Retrospective Studies KW - Prognosis KW - Vaginal Smears KW - Middle Aged KW - Dilatation and Curettage KW - Female KW - Uterine Hemorrhage -- diagnosis KW - Breast Neoplasms -- drug therapy KW - Fatty Liver -- diagnosis KW - Fatty Liver -- chemically induced KW - Breast Neoplasms -- pathology KW - Endometrium -- drug effects KW - Breast Neoplasms -- ethnology KW - Tamoxifen -- adverse effects KW - Endometrium -- pathology KW - Uterine Hemorrhage -- chemically induced KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Endometrium -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734088385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Tamoxifen+use+in+Indian+women--adverse+effects+revisited.&rft.au=Ashraf%2C+M%3BBiswas%2C+J%3BMajumdar%2C+S%3BNayak%2C+S%3BAlam%2C+N%3BMukherjee%2C+K+K%3BGupta%2C+S&rft.aulast=Ashraf&rft.aufirst=M&rft.date=2009-10-01&rft.volume=10&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-24 N1 - Date created - 2009-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression. AN - 734071924; 19577007 AB - HBV infection may reactivate in the setting of immunosuppression, although the frequency and consequences of HBV reactivation are not well known. We report 6 patients who experienced loss of serologic markers of hepatitis B immunity and reappearance of HBsAg in the serum as a result of a variety of acquired immune deficiencies. Between 2000 and 2005, six patients with reactivation of hepatitis B were seen in consultation by the Liver Diseases Branch at the Clinical Center, National Institutes of Health. The course and outcome of these 6 patients were reviewed. All 6 patients developed reappearance of HBsAg and evidence of active liver disease after stem cell transplantation (n = 4), immunosuppressive therapy (n = 1), or change in human immunodeficiency virus antiretroviral regimen (n = 1), despite having antibody to HBsAg (anti-HBs) or antibody to hepatitis B core antigen (anti-HBc) without HBsAg before. All 6 patients developed chronic hepatitis B, 2 patients transmitted hepatitis B to their spouses, and 1 patient developed cirrhosis. The diagnosis of hepatitis B reactivation was frequently missed or delayed and often required interruption of the therapy for the underlying condition. None of the patients received antiviral prophylaxis against HBV reactivation. Serologic evidence of recovery from hepatitis B infection does not preclude its reactivation after immunosuppression. Screening for serologic evidence of hepatitis B and prophylaxis of those with positive results by using nucleoside analogue antiviral therapy should be provided to individuals in whom immunosuppressive therapy is planned. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Palmore, Tara N AU - Shah, Neeral L AU - Loomba, Rohit AU - Borg, Brian B AU - Lopatin, Uri AU - Feld, Jordan J AU - Khokhar, Farooq AU - Lutchman, Glen AU - Kleiner, David E AU - Young, Neal S AU - Childs, Richard AU - Barrett, A John AU - Liang, T Jake AU - Hoofnagle, Jay H AU - Heller, Theo AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1888, Bethesda, Maryland 20892-1888, USA. tpalmore@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1130 EP - 1137 VL - 7 IS - 10 KW - Anti-HIV Agents KW - 0 KW - Hepatitis B Antibodies KW - Hepatitis B Surface Antigens KW - Immunosuppressive Agents KW - Index Medicus KW - HIV Infections -- complications KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Stem Cell Transplantation -- adverse effects KW - Hepatitis B Antibodies -- blood KW - Virus Activation -- drug effects KW - Anti-HIV Agents -- therapeutic use KW - Anti-HIV Agents -- adverse effects KW - Hepatitis B -- chemically induced KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- adverse effects KW - Hepatitis B Surface Antigens -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734071924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Reactivation+of+hepatitis+B+with+reappearance+of+hepatitis+B+surface+antigen+after+chemotherapy+and+immunosuppression.&rft.au=Palmore%2C+Tara+N%3BShah%2C+Neeral+L%3BLoomba%2C+Rohit%3BBorg%2C+Brian+B%3BLopatin%2C+Uri%3BFeld%2C+Jordan+J%3BKhokhar%2C+Farooq%3BLutchman%2C+Glen%3BKleiner%2C+David+E%3BYoung%2C+Neal+S%3BChilds%2C+Richard%3BBarrett%2C+A+John%3BLiang%2C+T+Jake%3BHoofnagle%2C+Jay+H%3BHeller%2C+Theo&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-10-01&rft.volume=7&rft.issue=10&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=1542-7714&rft_id=info:doi/10.1016%2Fj.cgh.2009.06.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-10-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 1999 Dec;24(11):1243-4 [10642815] Hematology. 2009 Apr;14(2):73-5 [19298717] Rev Med Virol. 2001 Sep-Oct;11(5):287-99 [11590667] Clin Transplant. 2001;15 Suppl 6:55-8 [11903388] Arch Surg. 2002 May;137(5):572-5; discussion 575-6 [11982471] Transplantation. 2002 May 27;73(10):1598-602 [12042646] Blood. 2002 Jul 15;100(2):391-6 [12091327] Bone Marrow Transplant. 2002 Aug;30(3):189-94 [12189538] Leuk Lymphoma. 2002 Nov;43(11):2159-63 [12533042] Transplantation. 2003 Apr 27;75(8):1179-86 [12717200] Leuk Lymphoma. 2003 May;44(5):759-66 [12802911] Ann Rheum Dis. 2003 Jul;62(7):686-7 [12810441] Gastroenterology. 2003 Dec;125(6):1742-9 [14724827] J Viral Hepat. 2004 Mar;11(2):141-7 [14996349] N Engl J Med. 2004 Mar 11;350(11):1118-29 [15014185] Bone Marrow Transplant. 2004 May;33(9):925-9 [15004543] N Engl J Med. 1974 Jun 13;290(24):1336-40 [4827644] Gastroenterology. 1975 Jan;68(1):105-12 [1054319] Ann Intern Med. 1982 Apr;96(4):447-9 [7065560] N Engl J Med. 1985 Jan 31;312(5):270-6 [2981408] N Engl J Med. 1987 Mar 5;316(10):630-1 [3807959] J Infect Dis. 1988 Sep;158(3):666-7 [3411157] AIDS. 1988 Oct;2(5):400-1 [3146272] AIDS. 1988 Dec;2(6):443-8 [3149492] Bone Marrow Transplant. 1989 Mar;4(2):207-8 [2650792] Transplantation. 1990 Apr;49(4):708-13 [2326865] J Hepatol. 1990 Jul;11(1):34-6 [2168915] Gastroenterology. 1991 Jan;100(1):182-8 [1983820] Hepatology. 1991 Jun;13(6):1044-51 [2050320] Vox Sang. 1992;63(2):107-11 [1441302] Lancet. 1994 Jan 15;343(8890):142-6 [7904004] Int J Hematol. 1993 Oct;58(3):183-8 [8148496] Transplantation. 1995 Jan 27;59(2):230-4 [7839446] Bone Marrow Transplant. 1995 Jan;15(1):145-8 [7742749] Hepatology. 1995 Jul;22(1):36-43 [7601429] Nat Med. 1996 Oct;2(10):1104-8 [8837608] J Hepatol. 1997 Mar;26(3):517-26 [9075658] Gastroenterology. 1997 Nov;113(5):1668-74 [9352871] J Hepatol. 1998 Aug;29(2):306-9 [9722213] Transplantation. 1998 Sep 15;66(5):616-9 [9753342] Transplantation. 1998 Oct 15;66(7):883-6 [9798698] Am J Gastroenterol. 1999 Jan;94(1):249-51 [9934765] Gastroenterol Clin Biol. 1999 Jun-Jul;23(6-7):770-4 [10470533] Liver Int. 2004 Dec;24(6):540-6 [15566502] J Clin Virol. 2005 Feb;32(2):162-5 [15653420] Eur J Haematol. 2005 Mar;74(3):254-8 [15693796] Transplantation. 2005 Mar 15;79(5):616-9 [15753855] Leuk Lymphoma. 2005 Jul;46(7):1085-9 [16019563] Eur J Clin Microbiol Infect Dis. 2005 Jul;24(7):492-4 [15990987] Am J Clin Oncol. 2005 Aug;28(4):379-84 [16062080] Semin Liver Dis. 2005;25 Suppl 1:3-8 [16103976] Clin Infect Dis. 2005 Nov 1;41(9):1277-82 [16206102] Clin Transplant. 2006 May-Jun;20(3):369-73 [16824156] Dig Dis Sci. 2006 Sep;51(9):1627-32 [16927141] Clin Gastroenterol Hepatol. 2006 Sep;4(9):1076-81 [16861051] Aliment Pharmacol Ther. 2006 Oct 1;24(7):1003-16 [16984494] J Clin Virol. 2007 Jan;38(1):83-6 [17134939] Gastroenterol Clin Biol. 2007 Jan;31(1):97-9 [17273140] Biol Blood Marrow Transplant. 2007 Apr;13(4):463-8 [17382252] Clin Exp Rheumatol. 2007 Nov-Dec;25(6):888-9 [18173926] J Gastroenterol. 2008;43(3):243-7 [18373168] Ann Intern Med. 2008 Apr 1;148(7):519-28 [18378948] Blood Transfus. 2008 Jan;6(1):46-50 [18661923] Bone Marrow Transplant. 2000 Jan;25(1):105-8 [10654023] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cgh.2009.06.027 ER - TY - JOUR T1 - MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. AN - 734068361; 19789312 AB - The dismal outcome of esophageal cancer patients highlights the need for novel prognostic biomarkers, such as microRNAs (miRNA). Although recent studies have established the role of miRNAs in esophageal carcinoma, a comprehensive multicenter study investigating different histologic types, including squamous cell carcinoma (SCC) and adenocarcinoma with or without Barrett's, is still lacking. miRNA expression was measured in cancerous and adjacent noncancerous tissue pairs collected from 100 adenocarcinoma and 70 SCC patients enrolled at four clinical centers from the United States, Canada, and Japan. Microarray-based expression was measured in a subset of samples in two cohorts and was validated in all available samples. In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue. In SCC patients, we found elevated miR-21 and reduced miR-375 expression levels in cancerous compared with noncancerous tissue. When comparing cancerous tissue expression between adenocarcinoma and SCC patients, miR-194 and miR-375 were elevated in adenocarcinoma patients. Significantly, elevated miR-21 expression in noncancerous tissue of SCC patients and reduced levels of miR-375 in cancerous tissue of adenocarcinoma patients with Barrett's were strongly associated with worse prognosis. Associations with prognosis were independent of tumor stage or nodal status, cohort type, and chemoradiation therapy. Our multicenter-based results highlight miRNAs involved in major histologic types of esophageal carcinoma and uncover significant associations with prognosis. Elucidating miRNAs relevant to esophageal carcinogenesis is potentially clinically useful for developing prognostic biomarkers and identifying novel drug targets and therapies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Mathé, Ewy A AU - Nguyen, Giang Huong AU - Bowman, Elise D AU - Zhao, Yiqiang AU - Budhu, Anuradha AU - Schetter, Aaron J AU - Braun, Rosemary AU - Reimers, Mark AU - Kumamoto, Kensuke AU - Hughes, Duncan AU - Altorki, Nasser K AU - Casson, Alan G AU - Liu, Chang-Gong AU - Wang, Xin Wei AU - Yanaihara, Nozomu AU - Hagiwara, Nobutoshi AU - Dannenberg, Andrew J AU - Miyashita, Masao AU - Croce, Carlo M AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA. Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 6192 EP - 6200 VL - 15 IS - 19 SN - 1078-0432, 1078-0432 KW - MicroRNAs KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Barrett Esophagus -- pathology KW - Barrett Esophagus -- genetics KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - MicroRNAs -- genetics KW - Carcinoma, Squamous Cell -- mortality KW - Adenocarcinoma -- mortality KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Adenocarcinoma -- genetics KW - Esophageal Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734068361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=MicroRNA+expression+in+squamous+cell+carcinoma+and+adenocarcinoma+of+the+esophagus%3A+associations+with+survival.&rft.au=Math%C3%A9%2C+Ewy+A%3BNguyen%2C+Giang+Huong%3BBowman%2C+Elise+D%3BZhao%2C+Yiqiang%3BBudhu%2C+Anuradha%3BSchetter%2C+Aaron+J%3BBraun%2C+Rosemary%3BReimers%2C+Mark%3BKumamoto%2C+Kensuke%3BHughes%2C+Duncan%3BAltorki%2C+Nasser+K%3BCasson%2C+Alan+G%3BLiu%2C+Chang-Gong%3BWang%2C+Xin+Wei%3BYanaihara%2C+Nozomu%3BHagiwara%2C+Nobutoshi%3BDannenberg%2C+Andrew+J%3BMiyashita%2C+Masao%3BCroce%2C+Carlo+M%3BHarris%2C+Curtis+C&rft.aulast=Math%C3%A9&rft.aufirst=Ewy&rft.date=2009-10-01&rft.volume=15&rft.issue=19&rft.spage=6192&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-1467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2005 Aug 15;65(16):7065-70 [16103053] Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] J Nutr. 2005 Dec;135(12 Suppl):2993S-3001S [16317160] Nature. 2005 Dec 1;438(7068):685-9 [16258535] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80 [16365291] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] J Natl Compr Canc Netw. 2006 Apr;4(4):367-74 [16569389] Clin Cancer Res. 2006 Dec 15;12(24):7322-8 [17121874] Int J Cancer. 2007 Mar 1;120(5):1046-54 [17149698] Am J Surg. 2007 May;193(5):614-7; discussion 617 [17434367] J Biol Chem. 2007 May 11;282(19):14328-36 [17363372] Blood. 2007 Jun 1;109(11):4944-51 [17327404] Int J Cancer. 2007 Sep 1;121(5):1156-61 [17487835] Blood. 2007 Aug 15;110(4):1330-3 [17496199] Gastroenterology. 2007 Aug;133(2):647-58 [17681183] J Natl Cancer Inst. 2007 Aug 15;99(16):1257-69 [17686824] Int J Cancer. 2007 Dec 1;121(11):2373-80 [17893866] Cancer Res. 2008 Jan 1;68(1):26-33 [18172293] Nat Rev Immunol. 2008 Feb;8(2):120-30 [18204468] JAMA. 2008 Jan 30;299(4):425-36 [18230780] J Thorac Cardiovasc Surg. 2008 Feb;135(2):255-60; discussion 260 [18242245] Hepatology. 2008 Mar;47(3):897-907 [18176954] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3903-8 [18308936] Oncogene. 2008 Apr 3;27(15):2128-36 [17968323] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4 [15210942] Semin Oncol. 2004 Aug;31(4):450-64 [15297938] Cell. 1993 Dec 3;75(5):843-54 [8252621] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Nature. 2008 Apr 17;452(7189):896-9 [18368051] Br J Cancer. 2008 Jun 17;98(12):1985-92 [18493233] Trends Immunol. 2008 Jul;29(7):343-51 [18515182] Eur J Cancer. 2008 Jul;44(11):1566-71 [18434132] Mol Biol Cell. 2008 Aug;19(8):3272-82 [18508928] Mol Cell Endocrinol. 2008 Dec 16;296(1-2):94-102 [18771702] Nucleic Acids Res. 2009 Jan;37(Database issue):D155-8 [18957447] Cancer Prev Res (Phila). 2008 Nov;1(6):485-93 [19138996] Clin Cancer Res. 2009 Mar 15;15(6):1915-22 [19276261] Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5813-8 [19289822] Cancer Biol Ther. 2009 Sep;8(18):1686-93 [19901517] Proc Natl Acad Sci U S A. 2002 May 14;99(10):6567-72 [12011421] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D109-11 [14681370] Ann Oncol. 2003;14 Suppl 5:v61-118 [14684501] Cell. 2004 Jan 23;116(2):281-97 [14744438] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004 [14973191] J Surg Oncol. 2005 Dec 1;92(3):230-8 [16299790] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-1467 ER - TY - JOUR T1 - Substance abuse in the United States: findings from recent epidemiologic studies. AN - 734062760; 19785975 AB - Recent research on the epidemiology of substance use disorders (SUDs) has provided important insights into these conditions and their impact on public health. In the United States, annual surveys of drug use in household and school populations serve as one of the primary sources of information about the distribution of illicit drug use. This research has demonstrated continued shifts in trends in illicit drug use in the United States and called attention to rising rates of prescription drug misuse and abuse. Findings have also continued to highlight the substantial comorbidity of SUDs with other psychiatric disorders and with the ongoing HIV epidemic. Building on these foundations, future challenges for research in substance abuse epidemiology will include using novel methodologic approaches to further unravel the complex interrelationships that link individual vulnerabilities for SUDs, including genetic factors, with social and environmental risk factors. JF - Current psychiatry reports AU - Schulden, Jeffrey D AU - Thomas, Yonette F AU - Compton, Wilson M AD - Epidemiology Research Branch, Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, MSC 9589, Bethesda, MD 20892-9589, USA. schuldenj@nida.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 353 EP - 359 VL - 11 IS - 5 KW - Index Medicus KW - Young Adult KW - Odds Ratio KW - Risk Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Genetic Predisposition to Disease KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Social Environment KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734062760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Substance+abuse+in+the+United+States%3A+findings+from+recent+epidemiologic+studies.&rft.au=Schulden%2C+Jeffrey+D%3BThomas%2C+Yonette+F%3BCompton%2C+Wilson+M&rft.aulast=Schulden&rft.aufirst=Jeffrey&rft.date=2009-10-01&rft.volume=11&rft.issue=5&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=1535-1645&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-04 N1 - Date created - 2009-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiol Rev. 2004;26:36-52 [15234946] JAMA. 2004 May 5;291(17):2114-21 [15126440] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] Arch Gen Psychiatry. 1995 Mar;52(3):219-29 [7872850] J Subst Abuse. 1995;7(4):481-97 [8838629] J Subst Abuse. 1996;8(2):195-210 [8880660] Addict Behav. 1998 Nov-Dec;23(6):893-907 [9801724] Arch Gen Psychiatry. 1998 Nov;55(11):982-8 [9819066] Drug Alcohol Depend. 1999 Feb 1;53(3):197-205 [10080045] Alcohol Clin Exp Res. 2004 Dec;28(12):1805-13 [15608596] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] Am J Psychiatry. 2005 Sep;162(9):1723-32 [16135633] Drug Alcohol Depend. 2006 Feb 1;81(2):103-7 [16023304] Drug Alcohol Depend. 2006 Feb 1;81(2):149-55 [16043307] Public Health Rep. 2006 Mar-Apr;121(2):127-32 [16528944] MMWR Morb Mortal Wkly Rep. 2006 Mar 17;55(10):273-7 [16543881] Ann Epidemiol. 2006 Apr;16(4):257-65 [16275134] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Pediatrics. 2006 Dec;118(6):2472-80 [17142533] J Adolesc Health. 2007 Jan;40(1):76-83 [17185209] Arch Gen Psychiatry. 2007 May;64(5):566-76 [17485608] Ann Behav Med. 2007 Aug;34(1):37-45 [17688395] J Rural Health. 2007 Fall;23 Suppl:1-3 [18237317] J Rural Health. 2007 Fall;23 Suppl:10-5 [18237319] J Acquir Immune Defic Syndr. 2008 Mar 1;47 Suppl 1:S15-9 [18301129] Annu Rev Clin Psychol. 2008;4:1-32 [18509902] Psychosom Med. 2008 Jun;70(5):606-11 [18519886] JAMA. 2008 Dec 10;300(22):2613-20 [19066381] Int J Drug Policy. 2009 May;20(3):209-16 [18930649] Clin Psychol Rev. 2000 Mar;20(2):173-89 [10721496] Prev Sci. 2000 Jun;1(2):89-106 [11521962] Ann N Y Acad Sci. 2001 Dec;954:6-18 [11797866] J Consult Clin Psychol. 2002 Feb;70(1):67-78 [11860058] Am J Psychiatry. 2002 Apr;159(4):607-14 [11925299] Am J Addict. 2002 Spring;11(2):85-94 [12028739] Science. 2002 Aug 2;297(5582):851-4 [12161658] Drug Alcohol Depend. 2003 Mar 1;69(2):127-35 [12609694] JAMA. 2003 Jul 2;290(1):40 [12837709] Arch Gen Psychiatry. 2003 Sep;60(9):929-37 [12963675] Ann Epidemiol. 2004 Feb;14(2):117-22 [15018884] Arch Gen Psychiatry. 2004 Apr;61(4):394-401 [15066898] Arch Gen Psychiatry. 2004 Jul;61(7):738-44 [15237086] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is resistance useless? Multidrug resistance and collateral sensitivity. AN - 734061155; 19762091 AB - When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide range of cancer drugs; its expression confers cross-resistance, termed "multidrug resistance" (MDR), to a wide range of drugs. Strategies to overcome this resistance have been actively sought for more than 30 years, yet clinical solutions do not exist. A less understood aspect of MDR is the hypersensitivity of resistant cancer cells to other drugs, a phenomenon known as "collateral sensitivity" (CS). This review highlights the extent of this effect for the first time, and discusses hypotheses (e.g. generation of reactive oxygen species) to account for the underlying generality of this phenomenon, and proposes exploitation of CS as a strategy to improve response to chemotherapy. JF - Trends in pharmacological sciences AU - Hall, Matthew D AU - Handley, Misty D AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 546 EP - 556 VL - 30 IS - 10 KW - Antineoplastic Agents KW - 0 KW - P-Glycoprotein KW - Reactive Oxygen Species KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Drug Interactions KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Humans KW - Cell Line, Tumor KW - P-Glycoprotein -- chemistry KW - Cell Line KW - Neoplasms -- drug therapy KW - Drug Resistance, Neoplasm -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Drug Resistance, Multiple -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734061155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+pharmacological+sciences&rft.atitle=Is+resistance+useless%3F+Multidrug+resistance+and+collateral+sensitivity.&rft.au=Hall%2C+Matthew+D%3BHandley%2C+Misty+D%3BGottesman%2C+Michael+M&rft.aulast=Hall&rft.aufirst=Matthew&rft.date=2009-10-01&rft.volume=30&rft.issue=10&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Trends+in+pharmacological+sciences&rft.issn=1873-3735&rft_id=info:doi/10.1016%2Fj.tips.2009.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-09-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Med Chem. 2003 Oct;38(10):893-8 [14575936] Biochem Pharmacol. 2004 Jan 15;67(2):269-76 [14698039] Carcinogenesis. 2004 Jun;25(6):941-9 [14729595] Int J Cancer. 2004 Sep 10;111(4):484-93 [15239124] 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Res. 2003 Jul;9(7):2504-9 [12855624] Eur J Pharmacol. 2003 Jul 18;473(1):9-17 [12877932] Biochemistry. 2003 Oct 28;42(42):12163-73 [14567677] Biochem J. 1996 Jan 1;313 ( Pt 1):163-9 [8546678] Cancer Chemother Pharmacol. 1996;37(5):457-62 [8599869] Blood. 1996 Mar 1;87(5):1962-71 [8634445] Biochemistry. 1996 Apr 16;35(15):4820-7 [8664272] Br J Cancer. 1996 Sep;74(6):888-96 [8826854] Oncol Res. 1996;8(2):77-84 [8859778] Br J Cancer. 1996 Dec;74(11):1719-29 [8956784] Cancer Res. 1997 Feb 15;57(4):720-7 [9044851] Br J Cancer. 1997;75(6):869-77 [9062409] J Natl Cancer Inst. 1997 Apr 2;89(7):512-8 [9086008] Cancer Lett. 1997 May 19;115(2):221-7 [9149128] Acta Med Okayama. 1997 Jun;51(3):121-7 [9227790] Biochem Pharmacol. 1997 Jun 15;53(12):1855-66 [9256160] Biochem Pharmacol. 1997 Sep 15;54(6):649-55 [9310341] J Neurooncol. 1998 Jan;36(1):41-53 [9525824] Adv Exp Med Biol. 1998;431:591-4 [9598134] Anticancer Res. 1998 Mar-Apr;18(2A):927-33 [9615743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tips.2009.07.003 ER - TY - JOUR T1 - Occupational risk of lung cancer among lifetime non-smoking women in Shanghai, China. AN - 734055238; 19625285 AB - Occupational lung carcinogens have been primarily studied in men. The aim of this study was to investigate occupational lung cancer risk in a cohort of Chinese non-smoking women. In 1996-2000, 71 067 non-smoking women who had held a job outside the home were interviewed for the prospective Shanghai Women's Health Study in China. Exposure to lung carcinogens was assessed by matching occupation and industry titles from lifetime occupational histories with lists of jobs identified by the International Agency for Research on Cancer to have potential exposure to: (1) known (A-list); or (2) suspected (B-list) carcinogens. In addition, similar occupational titles were grouped independent of the a priori defined lists. Relative risks (RRs) were calculated using Cox proportional hazards regression. During follow-up through 2005, 219 incident lung cancer cases were diagnosed. Jobs on the A-list and B-list were held by 0.8-6.7% and 2.7-9.4% of the cohort, respectively. Overall, ever holding any job on the A-list or B-list was not associated with lung cancer incidence. Indications of excess risk were found for two subgroups: painters (A-list) and rubber workers (B-list) (RR = 2.0 and 1.7, respectively, p100%), is not reflected by the intersubject variability in the blood compartment (coefficient of variation, 24%). Positron emission tomography imaging of the fluorine-18 analogue revealed the accumulation of the antiretroviral drug in the cortex of the kidneys, a potential correlate of tenofovir-induced nephrotoxicity observed in HIV-1-infected treated patients. Thus, [18F]FPMPA is a promising radiotracer for evaluation of tenofovir biodistribution under carefully controlled drug administration protocols. JF - Antimicrobial agents and chemotherapy AU - Di Mascio, Michele AU - Srinivasula, Sharat AU - Bhattacharjee, Abesh AU - Cheng, Lily AU - Martiniova, Lucia AU - Herscovitch, Peter AU - Lertora, Juan AU - Kiesewetter, Dale AD - Division of Clinical Research, Biostatistics Research Branch, National Institue of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. mdimascio@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 4086 EP - 4095 VL - 53 IS - 10 KW - Anti-HIV Agents KW - 0 KW - Fluorine Radioisotopes KW - Organophosphonates KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Rats KW - Lymph Nodes -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Testis -- metabolism KW - Colon -- metabolism KW - Antiretroviral Therapy, Highly Active KW - Brain -- metabolism KW - Male KW - Adenine -- therapeutic use KW - Organophosphonates -- therapeutic use KW - Anti-HIV Agents -- pharmacokinetics KW - Anti-HIV Agents -- therapeutic use KW - Positron-Emission Tomography -- methods KW - Adenine -- pharmacokinetics KW - Adenine -- analogs & derivatives KW - Organophosphonates -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733849009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Antiretroviral+tissue+kinetics%3A+in+vivo+imaging+using+positron+emission+tomography.&rft.au=Di+Mascio%2C+Michele%3BSrinivasula%2C+Sharat%3BBhattacharjee%2C+Abesh%3BCheng%2C+Lily%3BMartiniova%2C+Lucia%3BHerscovitch%2C+Peter%3BLertora%2C+Juan%3BKiesewetter%2C+Dale&rft.aulast=Di+Mascio&rft.aufirst=Michele&rft.date=2009-10-01&rft.volume=53&rft.issue=10&rft.spage=4086&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00419-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2003 Feb;77(3):2271-5 [12525664] Nucl Med Biol. 2002 Nov;29(8):777-82 [12453585] J Acquir Immune Defic Syndr. 2004 Jan 1;35(1):33-7 [14707789] Nucl Med Biol. 2004 Jul;31(5):613-21 [15219280] J Comput Assist Tomogr. 1981 Dec;5(6):783-91 [6976359] J Nucl Med. 1992 May;33(5):633-42 [1569473] Clin Investig. 1992 Jul;70(7):539-44 [1392422] Annu Rev Cell Biol. 1992;8:67-113 [1282354] Antimicrob Agents Chemother. 1993 Feb;37(2):332-8 [8452366] Annu Rev Biochem. 1993;62:385-427 [8102521] Clin Pharmacokinet. 1996 Apr;30(4):314-27 [8983861] JAMA. 1998 Feb 11;279(6):450-4 [9466638] Antimicrob Agents Chemother. 1998 Mar;42(3):687-90 [9517952] Eur J Nucl Med. 1998 Jun;25(6):565-74 [9618570] Antimicrob Agents Chemother. 1998 Sep;42(9):2380-4 [9736567] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11514-9 [9751697] CMAJ. 1999 Mar 9;160(5):659-65 [10102000] N Engl J Med. 1999 May 27;340(21):1605-13 [10341272] J Virol. 1999 Nov;73(11):9404-12 [10516049] J Infect Dis. 2005 Apr 1;191(7):1164-8 [15747253] AIDS. 2005 Mar 25;19(5):487-94 [15764854] Antimicrob Agents Chemother. 2005 May;49(5):1898-906 [15855512] Am J Kidney Dis. 2005 May;45(5):804-17 [15861345] Eur J Nucl Med Mol Imaging. 2005 May;32(5):593-600 [15791432] AIDS Rev. 2005 Apr-Jun;7(2):103-12 [16092504] J Virol. 2005 Nov;79(21):13572-8 [16227277] J Nucl Med. 2005 Nov;46(11):1835-41 [16269597] Antimicrob Agents Chemother. 2006 Oct;50(10):3297-304 [17005808] Pharm Res. 2007 Apr;24(4):811-5 [17372702] J Nucl Med. 2007 Apr;48(4):655-60 [17401105] AIDS. 2007 May 31;21(9):1119-27 [17502722] Trends Immunol. 2007 Dec;28(12):514-8 [17964854] Clin Pharmacol Ther. 2008 Jan;83(1):97-105 [17507921] J Acquir Immune Defic Syndr. 2008 Mar 1;47(3):298-303 [18398970] J Gen Virol. 2008 Jun;89(Pt 6):1467-77 [18474563] Lancet. 1999 Nov 20;354(9192):1782-5 [10577640] Nat Med. 2000 Jan;6(1):82-5 [10613829] AIDS. 2000 Feb 18;14(3):243-9 [10716500] J Clin Invest. 2000 Apr;105(7):995-1003 [10749578] Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7681-6 [10884399] Nat Med. 2000 Jul;6(7):757-61 [10888923] AIDS. 2000 Sep 8;14(13):1979-84 [10997403] IEEE Trans Med Imaging. 2000 Aug;19(8):798-804 [11055803] Antivir Ther. 2000 Sep;5(3):181-5 [11075937] Int J Antimicrob Agents. 2000 Nov;16(3):353-6 [11091062] J Nucl Med. 2001 Apr;42(4):679-84 [11337559] Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):641-8 [11563082] HIV Med. 2000 Jul;1 Suppl 2:18-22 [11737368] J Pharmacol Exp Ther. 2002 Apr;301(1):145-51 [11907168] Expert Opin Investig Drugs. 2003 Mar;12(3):401-12 [12605563] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AAC.00419-09 ER - TY - JOUR T1 - Manufacturing work and organizational stresses in export processing zones. AN - 733611675; 19834264 AB - In the light of global industrialization, much attention has been focused on occupational factors and their influence on the health and welfare of workers. This was a cross sectional study using stratified sampling technique based on industry sizes. The study sampled 24 industries, 6 were small scale industries and 9 each for medium and large scale industries. From the 24 industries, a total of 500 respondents for the questionnaire was taken. For occupational health and safety standards that industries have to comply with, there was low compliance among small-scale industries relative to the medium and large scale industries. Only one industry had an air cleaning device for cleaning contaminated air prior to emission into the external community. Among the 500 respondents, majority were female (88.8%), single (69.6%) and worked in the production or assembly-line station (87.4%). Sickness absenteeism was relative high among the workers in this study accounting for almost 54% among females and 48% among males. Many of the workers also reported of poor performance at work, boredom, tardiness and absenteeism. For association between work factors and personal factors, the following were found to be statistically significant at p=0.05. Boredom was associated with lack of skills training, lack of promotion, disincentives for sick leaves, poor relationship with boss and poor relationships with employers. On the other hand, poor performance was also associated with lack of skills training, lack of promotions, job insecurity, and poor relationship with employers. From the data generated, important issues that must be dealt with in work organizations include the quality of work life, and health and safety issues. Based on these findings, we can conclude that there are still issues on occupational health and safety (OHS) in the target site of export processing zones in the Philippines. There must be an active campaign for OHS in industries that are produce for the global market such as the target industries in this study. JF - Industrial health AU - Lu, Jinky Leilanie AD - National institutes of Health, University of the Philippines, Philippines. jinky_lu@yahoo.com Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 543 EP - 550 VL - 47 IS - 5 KW - Index Medicus KW - Philippines KW - Cross-Sectional Studies KW - Humans KW - Organizational Culture KW - Health Surveys KW - Absenteeism KW - Male KW - Female KW - Occupational Exposure -- statistics & numerical data KW - Occupational Exposure -- prevention & control KW - Occupational Health -- statistics & numerical data KW - Occupational Health Services -- organization & administration KW - Occupational Exposure -- analysis KW - Health Services Accessibility KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733611675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+health&rft.atitle=Manufacturing+work+and+organizational+stresses+in+export+processing+zones.&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2009-10-01&rft.volume=47&rft.issue=5&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Industrial+health&rft.issn=1880-8026&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-19 N1 - Date created - 2009-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approach to the patient after relapse of hairy cell leukemia. AN - 733605500; 19814696 AB - The current hairy cell leukemia (HCL) treatment is excellent, but evidence of cure with purine analogs cladribine and pentostatin, is lacking. Significant long-term immune suppression, particularly to CD4+ T-cells, and declining complete remission rates with each course, make the identification of new therapies an important goal. The anti-CD20 monoclonal antibody (Mab) rituximab displays significant activity, and, while causing prolonged normal B-cell depletion, spares T-cells. Recombinant immunotoxins, containing an Fv fragment of a Mab fused to truncated Pseudomonas exotoxin, have shown efficacy in HCL resistant to both purine analogs and rituximab. LMB-2 targets CD25 and can induce remission providing the HCL cells are CD25+. All HCL cells display CD22. Recombinant anti-CD22 immunotoxin BL22, targeting CD22, has shown significant efficacy in phase I and II testing, and avoids prolonged suppression of both normal B- and T-cells. An improved high-affinity version of BL22, termed HA22, is currently undergoing phase I testing. JF - Leukemia & lymphoma AU - Kreitman, Robert J AU - Fitzgerald, David J P AU - Pastan, Ira AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. kreitmar@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 32 EP - 37 VL - 50 Suppl 1 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - CD22 protein, human KW - IL2RA protein, human KW - Immunotoxins KW - Interleukin-2 Receptor alpha Subunit KW - Recombinant Proteins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Cladribine KW - 47M74X9YT5 KW - Index Medicus KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Combined Modality Therapy KW - Humans KW - Cladribine -- therapeutic use KW - Algorithms KW - Interleukin-2 Receptor alpha Subunit -- antagonists & inhibitors KW - Immunotoxins -- therapeutic use KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Recurrence KW - Recombinant Proteins -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Leukemia, Hairy Cell -- pathology KW - Leukemia, Hairy Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733605500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Approach+to+the+patient+after+relapse+of+hairy+cell+leukemia.&rft.au=Kreitman%2C+Robert+J%3BFitzgerald%2C+David+J+P%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-10-01&rft.volume=50+Suppl+1&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.3109%2F10428190903142216 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-17 N1 - Date created - 2009-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10428190903142216 ER - TY - JOUR T1 - Evaluation of a prototype real-time PCR assay for carcinogenic human papillomavirus (HPV) detection and simultaneous HPV genotype 16 (HPV16) and HPV18 genotyping. AN - 733599006; 19675214 AB - Results from a prototype real-time PCR assay that separately detected human papillomavirus genotype 16 (HPV16), HPV18, and 12 other carcinogenic HPV genotypes in aggregate (cobas 4800 HPV test) and results from a PCR assay that detects 37 HPV genotypes individually (Linear Array) were compared using a convenience sample of cervical specimens (n = 531). The percentage of total agreement between the two assays was 94.7% (95% confidence interval, 92.5 to 96.5%). The Linear Array test was more likely than cobas 4800 HPV test to test positive for the 12 other carcinogenic HPV genotypes among women without evidence of cervical disease (P = 0.004). JF - Journal of clinical microbiology AU - Castle, Philip E AU - Sadorra, Mark AU - Lau, Tiffany AU - Aldrich, Carrie AU - Garcia, Francisco A R AU - Kornegay, Janet AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 3344 EP - 3347 VL - 47 IS - 10 KW - Index Medicus KW - Sensitivity and Specificity KW - Human papillomavirus 18 -- genetics KW - Human papillomavirus 16 -- isolation & purification KW - Humans KW - Human papillomavirus 18 -- classification KW - Human papillomavirus 18 -- isolation & purification KW - Cervix Uteri -- virology KW - Human papillomavirus 16 -- genetics KW - Female KW - Human papillomavirus 16 -- classification KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733599006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Evaluation+of+a+prototype+real-time+PCR+assay+for+carcinogenic+human+papillomavirus+%28HPV%29+detection+and+simultaneous+HPV+genotype+16+%28HPV16%29+and+HPV18+genotyping.&rft.au=Castle%2C+Philip+E%3BSadorra%2C+Mark%3BLau%2C+Tiffany%3BAldrich%2C+Carrie%3BGarcia%2C+Francisco+A+R%3BKornegay%2C+Janet&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2009-10-01&rft.volume=47&rft.issue=10&rft.spage=3344&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/10.1128%2FJCM.00725-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Jan 5;283(1):87-93 [10632285] BMJ. 2009;339:b2569 [19638649] N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] J Clin Microbiol. 2006 Jun;44(6):1998-2006 [16757590] J Natl Cancer Inst. 2006 Jun 7;98(11):765-74 [16757701] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] J Clin Microbiol. 2006 Nov;44(11):3915-7 [16971652] Am J Clin Pathol. 2007 Mar;127(3):335-7 [17276947] Clin Cancer Res. 2007 May 1;13(9):2599-605 [17473189] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Clin Microbiol. 2007 Jul;45(7):2130-7 [17494721] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1248-54 [18483347] Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] J Clin Microbiol. 2008 Oct;46(10):3437-45 [18716224] BMJ. 2008;337:a1754 [18852164] Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3033-42 [18957520] Int J Cancer. 2009 Feb 1;124(3):516-20 [18973271] Obstet Gynecol. 2009 Mar;113(3):595-600 [19300322] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JCM.00725-09 ER - TY - JOUR T1 - Effect of rate of delivery of intravenous cocaine on self-administration in rats. AN - 733574649; 19464316 AB - Many studies of drug self-administration in primates have shown that faster infusions of a drug are more reinforcing than slower infusions. Similar effects have not been shown in rats. We assessed the influence of delivery rate by allowing rats to choose between the same doses of intravenous cocaine delivered over two different infusion speeds. Rats were trained in chambers containing two nose-poke response devices. In Experiment 1, responses in one nose-poke delivered 0.3 mg/kg/injection of cocaine over 10 s, and responses in the other delivered the same dose over 100 s. In Experiment 2, the same procedure was used, but with 1.0 mg/kg/injection dose delivered over 1.7 versus 100 s. During acquisition, most rats preferred the faster infusion. When the delivery rates associated with the nose pokes were reversed, rats trained with 0.3 mg/kg/injection failed to switch nose-poke preference, but half the rats trained with 1.0 mg/kg/injection did switch. In Experiment 3, the choice was between 1 mg/kg cocaine delivered over 1.7 s and no reinforcement. Here, rats quickly learned to respond in the nose-poke associated with cocaine and quickly switched their choice during reversal. In Experiment 4, two groups of rats were allowed to choose between food delivered with a delay of 1 versus 5 s or 1 versus 10 s, respectively. Rats preferred the shorter delay during initial training. In reversal, some rats in the 1 vs 5 s group failed to reverse, while all the rats in the 1 vs 10 s group reversed. These results show that faster infusions of cocaine are clearly more reinforcing during acquisition, but delivery rate may not be as important to the maintenance of self-administration once it has been established. The results with food suggest that these findings represent general principles of behavior and are not unique to drug self-administration. JF - Pharmacology, biochemistry, and behavior AU - Schindler, Charles W AU - Panlilio, Leigh V AU - Thorndike, Eric B AD - Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore, MD 21224, United States. cschindl@helix.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 375 EP - 381 VL - 93 IS - 4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Conditioning, Operant -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Reversal Learning -- drug effects KW - Infusions, Intravenous KW - Reinforcement (Psychology) KW - Male KW - Cocaine-Related Disorders -- psychology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733574649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Effect+of+rate+of+delivery+of+intravenous+cocaine+on+self-administration+in+rats.&rft.au=Schindler%2C+Charles+W%3BPanlilio%2C+Leigh+V%3BThorndike%2C+Eric+B&rft.aulast=Schindler&rft.aufirst=Charles&rft.date=2009-10-01&rft.volume=93&rft.issue=4&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=1873-5177&rft_id=info:doi/10.1016%2Fj.pbb.2009.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-27 N1 - Date created - 2009-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1996 Jun;125(3):202-8 [8815954] Psychopharmacology (Berl). 1993;112(2-3):343-51 [7871040] Adv Pharmacol. 1998;42:995-7 [9328065] Psychopharmacology (Berl). 1998 Jun;137(3):253-8 [9683003] Trends Pharmacol Sci. 2005 Feb;26(2):82-7 [15681025] Eur J Neurosci. 2005 Jul;22(1):195-200 [16029209] Curr Neurovasc Res. 2004 Jan;1(1):77-90 [16181068] Psychopharmacology (Berl). 2005 Sep;181(2):299-308 [15778873] Drug Alcohol Depend. 2006 Mar 15;82(1):19-24 [16144747] Pharmacol Biochem Behav. 2007 Jan;86(1):45-54 [17258302] Pharmacol Biochem Behav. 2008 Oct;90(4):797-804 [18586051] Behav Pharmacol. 2000 Feb;11(1):87-91 [10821213] J Neurosci. 2000 Jul 15;20(14):5526-37 [10884336] Psychopharmacology (Berl). 2001 Feb;154(1):76-84 [11292009] J Pharmacol Exp Ther. 2001 Dec;299(3):1056-65 [11714895] J Pharmacol Exp Ther. 2002 May;301(2):690-7 [11961074] Pharmacology. 2003 May;68(1):49-56 [12660479] Psychopharmacology (Berl). 2003 Apr;167(1):9-19 [12644888] Neuropsychopharmacology. 2003 May;28(5):919-31 [12637948] Eur J Pharmacol. 2004 Feb 23;486(3):251-7 [14985046] J Neurosci. 2004 Jul 14;24(28):6362-70 [15254092] J Exp Anal Behav. 1973 Jul;20(1):119-29 [4197505] Pharmacol Biochem Behav. 1987 Nov;28(3):407-10 [3685077] J Neurochem. 1991 Apr;56(4):1299-306 [2002342] Life Sci. 1992;51(22):1739-46 [1435082] Br J Addict. 1992 Nov;87(11):1527-36 [1458032] JAMA. 1996 Nov 20;276(19):1580-8 [8918856] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pbb.2009.05.008 ER - TY - JOUR T1 - Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma. AN - 733402469; 19618298 AB - Compared to other familial pheochromocytoma/paragangliomas (PHEO/PGLs), the succinate dehydrogenase subunit B (SDHB)-related PHEO/PGLs often present with aggressive and rapidly growing metastatic lesions. Currently, there is no proven effective treatment for malignant PHEO/PGLs. Here, we present a 35-year-old white man with primary malignant abdominal extra-adrenal 11 cm paraganglioma underwent surgical successful resection. But 6 months later, he developed extensive bone, liver, and lymph nodes metastasis, which were demonstrated by computed tomography scan and the (18)F-fluorodeoxyglucose positron emission tomography. However, his (123)I-metaiodobenzylguanidine scintigraphy was negative; therefore, the cyclophosphamide, vincristine, and dacarbazine (CVD) combination chemotherapy was initiated. The combination chemotherapy was very effective showing 80% overall reduction in the liver lesions and 75% overall reduction in the retroperitoneal mass and adenopathy, and normalization of plasma catecholamine and metanephrine levels. However, plasma levels of dopamine (DA) and methoxytyramine (MTY) were only partially affected and remained consistently elevated throughout the remaining period of follow-up evaluation. Genetic testing revealed an SDHB gene mutation. Here, we present an SDHB-related PHEO/PGL patient with extensive tumor burden, numerous organ lesions, and rapidly growing tumors, which responded extremely well to CVD therapy. We conclude patients with SDHB-related PHEO/PGLs can be particularly sensitive to CVD chemotherapy and may have an excellent outcome if this therapy is used and continued on periodic basis. The data in this patient also illustrate the importance of measuring plasma levels of DA and MTY to provide a more complete and accurate assessment of the biochemical response to therapy than provided by measurements restricted to other catecholamines and O-methylated metabolites. JF - Endocrine AU - He, J AU - Makey, D AU - Fojo, T AU - Adams, K T AU - Havekes, B AU - Eisenhofer, G AU - Sullivan, P AU - Lai, E W AU - Pacak, K AD - Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bldg 10, CRC, RM 1-E 3140, MSC 1109, Bethesda, MD, 20892-1109, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 189 EP - 193 VL - 36 IS - 2 KW - Vincristine KW - 5J49Q6B70F KW - Dacarbazine KW - 7GR28W0FJI KW - Cyclophosphamide KW - 8N3DW7272P KW - SDHB protein, human KW - EC 1.3.5.1 KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Index Medicus KW - Succinate Dehydrogenase -- genetics KW - Dacarbazine -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Male KW - Paraganglioma, Extra-Adrenal -- drug therapy KW - Abdominal Neoplasms -- pathology KW - Paraganglioma, Extra-Adrenal -- pathology KW - Liver Neoplasms -- drug therapy KW - Paraganglioma, Extra-Adrenal -- genetics KW - Abdominal Neoplasms -- surgery KW - Abdominal Neoplasms -- drug therapy KW - Liver Neoplasms -- surgery KW - Paraganglioma, Extra-Adrenal -- surgery KW - Liver Neoplasms -- secondary KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Abdominal Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733402469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine&rft.atitle=Successful+chemotherapy+of+hepatic+metastases+in+a+case+of+succinate+dehydrogenase+subunit+B-related+paraganglioma.&rft.au=He%2C+J%3BMakey%2C+D%3BFojo%2C+T%3BAdams%2C+K+T%3BHavekes%2C+B%3BEisenhofer%2C+G%3BSullivan%2C+P%3BLai%2C+E+W%3BPacak%2C+K&rft.aulast=He&rft.aufirst=J&rft.date=2009-10-01&rft.volume=36&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Endocrine&rft.issn=1559-0100&rft_id=info:doi/10.1007%2Fs12020-009-9219-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12020-009-9219-6 ER - TY - JOUR T1 - Timing of births and endometrial cancer risk in Swedish women. AN - 733350322; 19565342 AB - While a protective long-term effect of parity on endometrial cancer risk is well established, the impact of timing of births is not fully understood. We examined the relationship between endometrial cancer risk and reproductive characteristics in a population-based cohort of 2,674,465 Swedish women, 20-72 years of age. During follow-up from 1973 to 2004, 7,386 endometrial cancers were observed. Compared to uniparous women, nulliparous women had a significantly elevated endometrial cancer risk (hazard ratio [HR] = 1.32, 95% confidence interval [CI], 1.22-1.42). Endometrial cancer risk decreased with increasing parity; compared to uniparous women, women with > or =4 births had a HR = 0.66 (95% CI, 0.59-0.74); p-trend or =25 years since a last birth compared to women having given birth within 4 years. Our findings support that clearance of initiated cells during delivery may be important in endometrial carcinogenesis. JF - Cancer causes & control : CCC AU - Pfeiffer, Ruth M AU - Mitani, Aya AU - Landgren, Ola AU - Ekbom, Anders AU - Kristinsson, Sigurdur Y AU - Björkholm, Magnus AU - Biggar, Robert J AU - Brinton, Louise A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd. EPS/RM 8030, Bethesda, MD 20892-7244, USA. pfeiffer@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1441 EP - 1449 VL - 20 IS - 8 KW - Index Medicus KW - Registries KW - Parity -- physiology KW - Young Adult KW - Birth Order KW - Risk Factors KW - Maternal Age KW - Humans KW - Adult KW - Sweden -- epidemiology KW - Aged KW - Middle Aged KW - Time Factors KW - Female KW - Pregnancy KW - Birth Intervals KW - Carcinoma, Endometrioid -- etiology KW - Endometrial Neoplasms -- epidemiology KW - Carcinoma, Endometrioid -- epidemiology KW - Endometrial Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733350322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Timing+of+births+and+endometrial+cancer+risk+in+Swedish+women.&rft.au=Pfeiffer%2C+Ruth+M%3BMitani%2C+Aya%3BLandgren%2C+Ola%3BEkbom%2C+Anders%3BKristinsson%2C+Sigurdur+Y%3BBj%C3%B6rkholm%2C+Magnus%3BBiggar%2C+Robert+J%3BBrinton%2C+Louise+A&rft.aulast=Pfeiffer&rft.aufirst=Ruth&rft.date=2009-10-01&rft.volume=20&rft.issue=8&rft.spage=1441&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-009-9370-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Obstet Gynecol. 2000 Jan;182(1 Pt 1):23-9 [10649152] Acta Obstet Gynecol Scand. 2001 Mar;80(3):267-72 [11207494] Best Pract Res Clin Obstet Gynaecol. 2001 Jun;15(3):341-54 [11476557] Int J Cancer. 2002 Apr 20;98(6):912-5 [11948472] Cancer Causes Control. 2002 May;13(4):299-305 [12074499] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43 [12496040] Int J Cancer. 2004 Feb 10;108(4):613-9 [14696129] Fertil Steril. 2004 Jul;82(1):186-95 [15237010] J Natl Cancer Inst. 1984 Sep;73(3):667-71 [6590913] Acta Obstet Gynecol Scand. 1986;65(3):247-55 [3739631] Cancer Res. 1988 Nov 1;48(21):6217-21 [3167867] Am J Epidemiol. 1991 Mar 15;133(6):554-9 [2006641] Am J Obstet Gynecol. 1992 Nov;167(5):1317-25 [1442985] Am J Epidemiol. 1994 Apr 15;139(8):819-35 [8178795] Eur J Cancer. 1994;30A(7):969-73 [7946593] Lancet. 1994 Nov 5;344(8932):1250-4 [7967985] Int J Cancer. 1995 May 16;61(4):485-90 [7759154] Cancer Causes Control. 1995 Jul;6(4):283-91 [7548715] Am J Epidemiol. 1996 Jun 15;143(12):1195-202 [8651218] Int J Cancer. 1998 Jun 10;76(6):784-6 [9626340] Cancer Causes Control. 1999 Feb;10(1):43-9 [10334641] Stat Med. 2004 Dec 30;23(24):3803-20 [15580597] Epidemiology. 2005 Jul;16(4):500-7 [15951668] Epidemiology. 2005 Jul;16(4):508-15 [15951669] Cancer Causes Control. 2006 Sep;17(7):949-55 [16841262] Am J Obstet Gynecol. 2007 Mar;196(3):214.e1-7 [17346525] Br J Cancer. 2007 May 7;96(9):1450-6 [17426703] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9370-7 ER - TY - JOUR T1 - A phase I study of paclitaxel and continuous daily CAI in patients with refractory solid tumors. AN - 733302394; 19738417 AB - Carboxyamido-triazole (CAI) is a calcium influx inhibitor with anti-angiogenic and anti-invasive properties and stabilizes tumor progression in patients. We hypothesized daily oral micronized CAI with q3 week paclitaxel would be well-tolerated and active. Twenty-nine heavily pretreated patients [median 3 [0-7]] were enrolled on five dose levels. No additive or cumulative toxicity was observed, and grade III nonhematological toxicity was rare. Neutropenia was the most common hematologic toxicity, seen in 79% of patients, with a trend towards increasing grade with higher paclitaxel doses. The recommended phase II dose defined by the maximum tolerated dose (MTD) was CAI 250 mg daily and paclitaxel 200 mg/m(2) q3weeks. Pharmacokinetic analysis revealed paclitaxel increases CAI trough concentration at all dose levels by over 100% (p < 0.0001). A trend towards higher steady-state CAI trough concentrations was found in patients with a partial response (PR; p = 0.09). Six patients had confirmed PR (24%; 4-67 cycles, median 10); two patients had minor responses. Eligible patients with solid tumors received micronized CAI daily (150-250 mg PO) and paclitaxel intravenously q3weeks (175-250 mg/m(2)), sequentially escalating each drug. CAI preceded paclitaxel by one week to permit pharmacokinetic analysis. Patients were assessed for toxicity, pharmacokinetics and disease outcome. The MTD of the combination of CAI and paclitaxel is 250 mg daily and 200 mg/m(2) q3weeks, respectively. The combination is tolerable and has potential antitumor activity. JF - Cancer biology & therapy AU - Azad, Nilofer AU - Perroy, Alyssa AU - Gardner, Erin AU - Imamura, Chiyo K AU - Graves, Cynthia AU - Sarosy, Gisele A AU - Minasian, Lori AU - Kotz, Herbert AU - Raggio, Miranda AU - Figg, William D AU - Kohn, Elise C AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. nazad2@jhmi.edu Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1800 EP - 1805 VL - 8 IS - 19 KW - Triazoles KW - 0 KW - carboxyamido-triazole KW - 99519-84-3 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Young Adult KW - Drug Interactions KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Female KW - Triazoles -- administration & dosage KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733302394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=A+phase+I+study+of+paclitaxel+and+continuous+daily+CAI+in+patients+with+refractory+solid+tumors.&rft.au=Azad%2C+Nilofer%3BPerroy%2C+Alyssa%3BGardner%2C+Erin%3BImamura%2C+Chiyo+K%3BGraves%2C+Cynthia%3BSarosy%2C+Gisele+A%3BMinasian%2C+Lori%3BKotz%2C+Herbert%3BRaggio%2C+Miranda%3BFigg%2C+William+D%3BKohn%2C+Elise+C&rft.aulast=Azad&rft.aufirst=Nilofer&rft.date=2009-10-01&rft.volume=8&rft.issue=19&rft.spage=1800&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-21 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2003 Dec 1;21(23):4356-63 [14645425] Int J Cancer. 2008 Jul 15;123(2):258-63 [18464258] J Biol Chem. 1991 Jun 5;266(16):10136-42 [1645340] J Pharmacol Exp Ther. 1991 Jun;257(3):967-71 [1646332] J Invest Dermatol. 1991 Dec;97(6):985-94 [1721081] Cancer Res. 1992 Jun 1;52(11):3208-12 [1591730] Biochemistry. 1992 Sep 22;31(37):8849-55 [1382581] Cell Calcium. 1992 Oct;13(9):553-64 [1334809] Cancer Res. 1994 Feb 15;54(4):935-42 [8313384] J Biol Chem. 1994 Aug 26;269(34):21505-11 [8063786] Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1307-11 [7533291] Cancer Res. 1996 Feb 1;56(3):569-73 [8564973] Mol Endocrinol. 1997 Mar;11(3):281-91 [9058375] J Clin Oncol. 1997 May;15(5):1985-93 [9164210] Clin Cancer Res. 1995 Aug;1(8):797-803 [9816048] J Cell Sci. 1999 Oct;112 ( Pt 19):3205-13 [10504326] Anticancer Res. 2004 Sep-Oct;24(5A):2869-77 [15517890] Curr Eye Res. 2005 Feb;30(2):103-13 [15814468] J Clin Oncol. 2005 Jun 1;23(16):3726-32 [15923569] J Cell Physiol. 2008 Apr;215(1):111-21 [17924401] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):213-8 [18191625] J Pharmacol Exp Ther. 2008 Apr;325(1):10-6 [18182559] Clin Cancer Res. 2001 Jun;7(6):1600-9 [11410496] J Clin Oncol. 2002 May 1;20(9):2365-9 [11981009] Biochem Biophys Res Commun. 2003 Feb 21;301(4):907-14 [12589798] Lung Cancer. 2008 May;60(2):200-7 [18045731] Cell. 1988 Jun 3;53(5):769-80 [2836067] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intercellular communication of cellular stress monitored by gamma-H2AX induction. AN - 67686311; 19651821 AB - When cells are exposed to ionizing radiation (IR), unexposed cells that share media with damaged cells exhibit similar effects to irradiated cells including increased levels of DNA double-strand breaks (DSBs). Hypothesizing that this effect, known as the radiation-induced bystander effect, may be a specific instance of communication between damaged and undamaged cells regardless of damage source, we demonstrated that exposure of target cells to non-IR induces bystander damage in non-targeted cells as measured by gamma-H2AX and 53BP1 focal formation. Initially, bystander damage was found primarily in S-phase cells, but at later times, non-S-phase cells were also affected. In addition, media from undamaged malignant and senescent cells also was found to induce DSBs in primary cultures. Media conditioned on cells targeted with either ionizing or non-IR as well as on undamaged malignant and senescent cells contained elevated levels of several cytokines. One of these, transforming growth factor beta (TGF-beta), and nitric oxide (NO) were found to elevate numbers of gamma-H2AX/53BP1 foci in normal cell cultures similar to levels found in bystander cells, and this elevation was abrogated by NO synthase inhibitors, TGF-beta blocking antibody and antioxidants. These findings support the hypothesis that damage in bystander cells results from their exposure to cytokines or reactive compounds released from stressed cells, regardless of damage source. These results have implications for oncogenesis in that they indicate that damaged normal cells or undamaged tumor cells may induce genomic instability, leading to an increased risk of oncogenic transformation in other cells with which they share media or contact directly. JF - Carcinogenesis AU - Dickey, Jennifer S AU - Baird, Brandon J AU - Redon, Christophe E AU - Sokolov, Mykyta V AU - Sedelnikova, Olga A AU - Bonner, William M AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA. dickeyj@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1686 EP - 1695 VL - 30 IS - 10 KW - DNA, Neoplasm KW - 0 KW - Enzyme Inhibitors KW - H2AFX protein, human KW - Histones KW - Transforming Growth Factor beta KW - Nitric Oxide KW - 31C4KY9ESH KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Index Medicus KW - Stress, Physiological -- physiology KW - Transforming Growth Factor beta -- pharmacology KW - Ultraviolet Rays KW - Humans KW - S Phase KW - Fibroblasts -- cytology KW - HeLa Cells -- cytology KW - Fibroblasts -- physiology KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Breast -- cytology KW - Nitric Oxide -- pharmacology KW - Breast -- physiology KW - DNA, Neoplasm -- genetics KW - Enzyme Inhibitors -- pharmacology KW - Uterine Cervical Neoplasms -- genetics KW - HeLa Cells -- physiology KW - Cell Transformation, Neoplastic KW - Female KW - Cell Division -- radiation effects KW - HeLa Cells -- radiation effects KW - Histones -- metabolism KW - Cell Communication -- physiology KW - Histones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67686311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Intercellular+communication+of+cellular+stress+monitored+by+gamma-H2AX+induction.&rft.au=Dickey%2C+Jennifer+S%3BBaird%2C+Brandon+J%3BRedon%2C+Christophe+E%3BSokolov%2C+Mykyta+V%3BSedelnikova%2C+Olga+A%3BBonner%2C+William+M&rft.aulast=Dickey&rft.aufirst=Jennifer&rft.date=2009-10-01&rft.volume=30&rft.issue=10&rft.spage=1686&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp192 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-26 N1 - Date created - 2009-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Oct 1;62(19):5436-42 [12359750] Radiat Res. 2009 Feb;171(2):204-11 [19267546] Oncogene. 2003 Oct 13;22(45):7050-7 [14557810] Hepatology. 2004 Jun;39(6):1663-72 [15185308] Mutat Res. 2004 Nov 22;556(1-2):209-15 [15491649] Cancer Res. 1992 Nov 15;52(22):6394-6 [1423287] Radiat Res. 1993 May;134(2):160-9 [7683818] Mutagenesis. 1995 Sep;10(5):453-6 [8544761] Methods Enzymol. 1996;268:281-93 [8782594] J Cell Biol. 1999 Sep 6;146(5):905-16 [10477747] Annu Rev Physiol. 2005;67:225-57 [15709958] Radiat Res. 2005 Mar;163(3):316-23 [15733038] Nat Rev Immunol. 2005 Mar;5(3):243-51 [15738954] Mutat Res. 2005 Apr 1;571(1-2):19-31 [15748635] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14641-6 [16203985] Oncogene. 2005 Nov 10;24(49):7257-65 [16170376] Carcinogenesis. 2006 Feb;27(2):245-51 [16150894] Mutat Res. 2006 May 11;597(1-2):1-4 [16414091] Mol Carcinog. 2006 Jun;45(6):455-60 [16637062] Toxicol In Vitro. 2006 Sep;20(6):975-85 [16469478] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9891-6 [16788066] Oncogene. 2006 Jul 20;25(31):4267-75 [16532033] Biochem Pharmacol. 2006 Nov 30;72(11):1605-21 [16889756] Cancer Res. 2007 Feb 1;67(3):1246-53 [17283161] Oncogene. 2007 Feb 15;26(7):993-1002 [16909103] J Mol Biol. 2007 Mar 30;367(3):665-80 [17280685] Oncogene. 2007 Apr 5;26(16):2330-9 [17016433] Radiat Prot Dosimetry. 2006;122(1-4):256-9 [17164279] Cancer Res. 2007 May 1;67(9):4295-302 [17483342] Cell. 2007 May 18;129(4):665-79 [17512402] Cancer Res. 2007 Jun 15;67(12):5872-9 [17575156] J Radiat Res. 2007 Jul;48(4):327-33 [17587774] Cell Cycle. 2007 Sep 15;6(18):2210-2 [17881892] Oncogene. 2007 Dec 10;26(56):7765-72 [18066089] N Engl J Med. 2007 Dec 20;357(25):2543-51 [18094375] Photochem Photobiol. 2008 Jan-Feb;84(1):67-8 [18173703] Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):605-10 [18195365] Oncogene. 2008 Jan 17;27(4):434-40 [17621264] Immunol Lett. 2008 Jun 30;118(2):116-24 [18495253] J Pharm Pharmacol. 2008 Aug;60(8):943-50 [18644187] Exp Dermatol. 2008 Dec;17(12):1037-44 [18459971] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] PLoS Biol. 2008 Dec 2;6(12):2853-68 [19053174] Cancer Res. 2009 Jan 1;69(1):37-44 [19117985] Radiat Res. 2008 Dec;170(6):794-802 [19138042] Mech Ageing Dev. 2009 Jan-Feb;130(1-2):1-2 [19059279] Phys Med Biol. 2009 Mar 7;54(5):L11-3; author reply L15-21 [19204382] Mutat Res. 2002 Oct 31;508(1-2):121-9 [12379467] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp192 ER - TY - JOUR T1 - Pathology in practice. Severe multifocal to locally extensive, monophasic skeletal muscle necrosis and multifocal, monophasic myocardial necrosis. AN - 67674618; 19793010 JF - Journal of the American Veterinary Medical Association AU - Webster, Joshua D AU - Horstman, Lawrence A AU - Miller, Margaret A AD - Animal Disease Diagnostic Laboratory, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA. websterjd@mail.nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 827 EP - 829 VL - 235 IS - 7 SN - 0003-1488, 0003-1488 KW - Index Medicus KW - Fatal Outcome KW - Animals KW - Cattle KW - Female KW - Muscular Diseases -- pathology KW - Necrosis -- veterinary KW - Cattle Diseases -- pathology KW - Muscular Diseases -- chemically induced KW - Necrosis -- chemically induced KW - Heart Diseases -- chemically induced KW - Heart Diseases -- veterinary KW - Necrosis -- pathology KW - Muscular Diseases -- veterinary KW - Plants, Toxic -- toxicity KW - Cattle Diseases -- chemically induced KW - Heart Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67674618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Veterinary+Medical+Association&rft.atitle=Pathology+in+practice.+Severe+multifocal+to+locally+extensive%2C+monophasic+skeletal+muscle+necrosis+and+multifocal%2C+monophasic+myocardial+necrosis.&rft.au=Webster%2C+Joshua+D%3BHorstman%2C+Lawrence+A%3BMiller%2C+Margaret+A&rft.aulast=Webster&rft.aufirst=Joshua&rft.date=2009-10-01&rft.volume=235&rft.issue=7&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Veterinary+Medical+Association&rft.issn=00031488&rft_id=info:doi/10.2460%2Fjavma.235.7.827 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-06 N1 - Date created - 2009-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2460/javma.235.7.827 ER - TY - JOUR T1 - Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. AN - 67667428; 19443712 AB - To investigate the role of HtrA2/Omi, a nuclear-encoded mitochondrial serine protease with a proapoptosis function, under H(2)O(2)-induced oxidative stress in human RPE, in the Ccl2(-)(/)(-)Cx3cr1(-)(/)(-) double-knockout (DKO) mouse retina, and the HtrA2/Omi-deficient mice. Oxidative stress was induced in ARPE-19 cells by 1 mM H(2)O(2) for 2 hours. HtrA2/Omi and caspase-3 expression was evaluated using RQ-PCR, immunohistochemistry, or Western blot. Cell viability was detected by MTT assay. HtrA2/Omi expression in the subcellular components and activated caspase-3 were measured. These processes were also evaluated in cells treated with UCF-101, an HtrA2/Omi inhibitor or in cells subjected to RNAi against HtrA2/Omi. Oxidative stress was assayed and compared in retinas of DKO and wild-type (WT) mice by determining serum NADPH oxidase subunits and nitrite levels. Transmission electron microscopy was used to view the retinal ultrastructure of the HtrA2/Omi-deficient mice. H(2)O(2)-induced oxidative damage resulted in HtrA2/Omi translocation from mitochondria to cytosol, leading to RPE cell apoptosis via a caspase-mediated pathway. Treatment of RPE cells with UCF-101 reduced the cytosolic translocation of HtrA2/Omi, attenuated caspase-3 activation, and decreased apoptosis. After specific HtrA2 downregulation, increased cell viability was measured in H(2)O(2)-treated ARPE-19 cells. Retina of DKO mice exhibit increased oxidative stress and upregulation of HtrA2/Omi. Fewer and abnormal mitochondria were found in HtrA2/Omi(-)(/)(-) photoreceptors and RPE. These findings suggest that HtrA2/Omi is related to RPE apoptosis due to oxidative stress, which may play an important role in the integrity of mitochondria and the pathogenesis of AMD. JF - Investigative ophthalmology & visual science AU - Ding, Xiaoyan AU - Patel, Mrinali AU - Shen, Defen AU - Herzlich, Alexandra A AU - Cao, Xiaoguang AU - Villasmil, Rafael AU - Klupsch, Kristina AU - Tuo, Jingsheng AU - Downward, Julian AU - Chan, Chi-Chao AD - Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 4957 EP - 4966 VL - 50 IS - 10 KW - Ccl2 protein, mouse KW - 0 KW - Chemokine CCL2 KW - Cx3cr1 protein, mouse KW - Enzyme Inhibitors KW - Mitochondrial Proteins KW - Pyrimidinones KW - Receptors, Chemokine KW - Thiones KW - UCF 101 KW - X-Linked Inhibitor of Apoptosis Protein KW - XIAP protein, human KW - Hydrogen Peroxide KW - BBX060AN9V KW - Omi serine protease KW - EC 3.4.21.- KW - Serine Endopeptidases KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Index Medicus KW - Animals KW - Chemokine CCL2 -- genetics KW - Apoptosis KW - Fluorescent Antibody Technique, Indirect KW - Protein Transport -- drug effects KW - Mitochondria -- enzymology KW - Cytosol -- enzymology KW - Humans KW - Receptors, Chemokine -- genetics KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - X-Linked Inhibitor of Apoptosis Protein -- metabolism KW - Mice, Knockout KW - Cell Survival KW - Hydrogen Peroxide -- toxicity KW - Blotting, Western KW - Thiones -- pharmacology KW - Pyrimidinones -- pharmacology KW - Oxidative Stress -- drug effects KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - RNA Interference KW - Cell Line KW - Serine Endopeptidases -- metabolism KW - Serine Endopeptidases -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Retinal Pigment Epithelium -- enzymology KW - Retinal Degeneration -- enzymology KW - Mitochondrial Proteins -- antagonists & inhibitors KW - Mitochondrial Proteins -- genetics KW - Disease Models, Animal KW - Retinal Pigment Epithelium -- drug effects KW - Mitochondrial Proteins -- metabolism KW - Retinal Degeneration -- pathology KW - Retinal Pigment Epithelium -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67667428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Enhanced+HtrA2%2FOmi+expression+in+oxidative+injury+to+retinal+pigment+epithelial+cells+and+murine+models+of+neurodegeneration.&rft.au=Ding%2C+Xiaoyan%3BPatel%2C+Mrinali%3BShen%2C+Defen%3BHerzlich%2C+Alexandra+A%3BCao%2C+Xiaoguang%3BVillasmil%2C+Rafael%3BKlupsch%2C+Kristina%3BTuo%2C+Jingsheng%3BDownward%2C+Julian%3BChan%2C+Chi-Chao&rft.aulast=Ding&rft.aufirst=Xiaoyan&rft.date=2009-10-01&rft.volume=50&rft.issue=10&rft.spage=4957&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.09-3381 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-02 N1 - Date created - 2009-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photochem Photobiol. 2004 May;79(5):470-5 [15191057] Cell Death Differ. 2002 Jul;9(7):699-701 [12058274] J Immunol. 1988 Oct 1;141(7):2407-12 [3139757] Prog Retin Eye Res. 2000 Mar;19(2):205-21 [10674708] Nat Med. 2000 May;6(5):513-9 [10802706] Protein Expr Purif. 2000 Jul;19(2):227-34 [10873535] Eur J Biochem. 2000 Sep;267(18):5699-710 [10971580] Nat Genet. 2000 Nov;26(3):270-1 [11062461] Mol Cell. 2001 Sep;8(3):613-21 [11583623] Arch Ophthalmol. 2001 Oct;119(10):1417-36 [11594942] J Biol Chem. 2002 Jan 4;277(1):439-44 [11602612] J Biol Chem. 2002 Jan 4;277(1):432-8 [11606597] Arch Ophthalmol. 2002 Nov;120(11):1435-42 [12427055] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14682-7 [12391305] Exp Eye Res. 2003 Apr;76(4):397-403 [12634104] J Biol Chem. 2003 Mar 28;278(13):11489-94 [12529364] Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1775-82 [12657621] J Fr Ophtalmol. 2003 Mar;26(3):307-11 [12746610] Eye (Lond). 2003 May;17(4):457-66 [12802343] Invest Ophthalmol Vis Sci. 2004 Feb;45(2):675-84 [14744914] Development. 2004 Mar;131(5):1041-53 [14973287] Arch Ophthalmol. 2004 Apr;122(4):564-72 [15078675] Invest Ophthalmol Vis Sci. 1989 Aug;30(8):1691-9 [2759786] Ophthalmology. 1993 Oct;100(10):1519-35 [7692366] Science. 1998 Aug 28;281(5381):1309-12 [9721092] Nature. 1999 Feb 4;397(6718):441-6 [9989411] Genes Dev. 1999 Feb 1;13(3):239-52 [9990849] Curr Opin Cell Biol. 2004 Dec;16(6):639-46 [15530775] Circulation. 2005 Jan 4;111(1):90-6 [15611365] Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3426-34 [16123448] Mol Cells. 2005 Aug 31;20(1):83-9 [16258245] J Biol Chem. 2006 Mar 10;281(10):6124-9 [16377621] Science. 2006 Nov 10;314(5801):989-92 [17053108] Science. 2006 Nov 10;314(5801):992-3 [17053109] Ann Med. 2006;38(7):450-71 [17101537] Am J Ophthalmol. 2007 Apr;143(4):607-15 [17280640] Cell Cycle. 2007 May 2;6(9):1122-5 [17426452] J Hum Genet. 2007;52(7):636-41 [17568988] Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36 [17652758] Prog Retin Eye Res. 2007 Sep;26(5):516-54 [17532250] Biochem Biophys Res Commun. 2007 Oct 19;362(2):295-300 [17707776] Cell Res. 2007 Sep;17(9):759-71 [17576411] Nat Cell Biol. 2007 Nov;9(11):1243-52 [17906618] Immunology. 2008 Jan;123(1):40-4 [18154618] Ophthalmic Res. 2008;40(3-4):124-8 [18421225] Hum Mutat. 2008 Jun;29(6):832-40 [18401856] Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2357-65 [18316707] Ophthalmology. 2008 Nov;115(11):1891-8 [18718667] Prog Retin Eye Res. 2009 Jan;28(1):1-18 [19026761] Mol Cell Biol. 2004 Nov;24(22):9848-62 [15509788] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.09-3381 ER - TY - JOUR T1 - Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. AN - 67666408; 19628633 AB - The mammalian bombesin (Bn) peptides, neuromedin B (NMB) and gastrin-releasing peptide (GRP), have widespread actions in many tissues, and their effects are mediated by two closely related G-protein-coupled receptors, the NMBR and GRPR. Little is known about the structural determinants of NMBR selectivity for NMB, in contrast to GRP selectivity for the GRPR, which has been extensively studied. To provide insight, chimeric NMBR-GRPR loss-of-affinity and gain-of-affinity mutants were made, as well as NH(2)-terminally truncated NMBR and point mutants using site-directed mutagenesis. Receptors were expressed in Balb-3T3-cells or CHOP cells, and affinities were determined. NMB had 115-fold greater affinity for NMBR than GRPR. Receptor-chimeric studies showed that NMBR selectivity for NMB was primarily determined by differences in the third extracellular (EC3) regions of GRPR-NMBR and adjacent upper-transmembrane-5 (TM5) region. In this region, 24 NMB gain-of-affinity GRPR mutants or NMBR loss-of-affinity point/combination mutants were made. Three gain-of-affinity mutant GRPRs [[A198I] (EC3), [H202Q] (EC3), [S215I] (upper TM5)] had increased NMB affinity (2.4-21-fold), and these results were confirmed with NMBR loss-of-affinity mutants [I199A,Q203H,I215S-NMBR]. The combination mutant [A198I,S215]GRPR had the greatest effect causing a complete NMB gain-of-affinity. The importance of differences at position 199NMBR or 203NMBR was studied by substituting amino acids with various properties. Our results show that NMBR selectivity for NMB is due to differences in the EC3 of NMBR-GRPR and the adjacent upper-TM5 region. Within these regions, isoleucines in NMBR [position 199 (EC3)] (instead of A198GRPR) and in 215NMBR (TM5) (instead of S214GRPR), as well as Q203NMBR (instead of H202GRPR) are responsible for high NMB-affinity/selectivity of NMBR. The effect at position 199 is primarily due to differences in hydrophobicity of the substitution, whereas steric factors and charge of the substitution at position 203 were important determinants of NMB selectivity. JF - The Journal of pharmacology and experimental therapeutics AU - González, Nieves AU - Nakagawa, Tomoo AU - Mantey, Samuel A AU - Sancho, Veronica AU - Uehara, Hirotsugu AU - Katsuno, Tatsuro AU - Jensen, Robert T AD - Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 265 EP - 276 VL - 331 IS - 1 KW - Receptors, Bombesin KW - 0 KW - Neurokinin B KW - 86933-75-7 KW - neuromedin B KW - 87096-84-2 KW - Index Medicus KW - Animals KW - Cricetulus KW - Amino Acid Sequence KW - Mice KW - Mice, Inbred BALB C KW - NIH 3T3 Cells KW - Rats KW - Protein Structure, Tertiary -- genetics KW - Amino Acid Substitution -- genetics KW - Extracellular Space -- metabolism KW - Extracellular Space -- genetics KW - Molecular Sequence Data KW - Protein Binding -- genetics KW - Cricetinae KW - Receptors, Bombesin -- genetics KW - Neurokinin B -- genetics KW - Receptors, Bombesin -- metabolism KW - Neurokinin B -- metabolism KW - Neurokinin B -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67666408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Molecular+basis+for+the+selectivity+of+the+mammalian+bombesin+peptide%2C+neuromedin+B%2C+for+its+receptor.&rft.au=Gonz%C3%A1lez%2C+Nieves%3BNakagawa%2C+Tomoo%3BMantey%2C+Samuel+A%3BSancho%2C+Veronica%3BUehara%2C+Hirotsugu%3BKatsuno%2C+Tatsuro%3BJensen%2C+Robert+T&rft.aulast=Gonz%C3%A1lez&rft.aufirst=Nieves&rft.date=2009-10-01&rft.volume=331&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.109.154245 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2003 Dec 30;42(51):15326-32 [14690442] Pharmacol Rev. 2008 Mar;60(1):1-42 [18055507] Nature. 1985 Aug 29-Sep 4;316(6031):823-6 [2993906] Am J Physiol. 1989 Apr;256(4 Pt 1):G747-58 [2539739] Peptides. 1990 May-Jun;11(3):595-607 [2199952] Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):395-9 [1671171] Bioorg Med Chem. 1999 Dec;7(12):2867-76 [10658591] Regul Pept. 2000 Jun 30;90(1-3):77-84 [10828496] J Biol Chem. 2001 Jan 5;276(1):495-504 [11013243] Peptides. 2001 Apr;22(4):689-99 [11311741] J Biol Chem. 2001 Sep 28;276(39):36652-63 [11463790] J Biol Chem. 2002 Mar 1;277(9):7546-55 [11724786] Clin Cancer Res. 2002 Apr;8(4):1139-46 [11948125] Mol Pharmacol. 2002 Jun;61(6):1435-43 [12021405] J Pharmacol Exp Ther. 2003 Mar;304(3):1217-27 [12604699] Neuron. 1991 Mar;6(3):421-30 [1848080] Anal Biochem. 1991 Feb 15;193(1):72-82 [2042744] Brain Res. 1992 Oct 16;593(2):168-78 [1333344] J Biol Chem. 1992 Dec 25;267(36):25668-71 [1281470] Mol Pharmacol. 1992 Dec;42(6):1058-68 [1336112] J Biol Chem. 1993 Jul 15;268(20):14622-6 [8392057] J Biol Chem. 1993 Sep 25;268(27):20285-90 [8397203] Mol Pharmacol. 1994 Aug;46(2):235-45 [8078487] J Biol Chem. 1995 Jun 16;270(24):14394-8 [7782300] J Biol Chem. 1996 Jan 26;271(4):1950-6 [8567643] J Biol Chem. 1996 May 31;271(22):12795-800 [8662697] J Biol Chem. 1996 Jun 21;271(25):14698-706 [8663021] J Biol Chem. 1996 Dec 13;271(50):32016-20 [8943250] Mol Pharmacol. 1997 May;51(5):721-32 [9145910] J Biol Chem. 1997 Jul 11;272(28):17405-9 [9211882] J Biol Chem. 1997 Oct 10;272(41):26062-71 [9325344] Mol Endocrinol. 1997 Dec;11(13):2048-53 [9415408] Mol Pharmacol. 1997 Dec;52(6):983-92 [9415708] Eur J Pharmacol. 1998 Feb 19;343(2-3):275-87 [9570477] J Biol Chem. 1998 Jun 26;273(26):15927-32 [9632639] Mol Pharmacol. 1998 Aug;54(2):364-71 [9687578] J Biol Chem. 1999 Aug 13;274(33):23191-7 [10438490] J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11 [10454496] Biochem Pharmacol. 2005 Feb 15;69(4):579-93 [15670577] J Biochem Mol Biol. 2006 Mar 31;39(2):223-7 [16584639] Biochem Pharmacol. 2006 Jul 14;72(2):244-55 [16750175] J Pharmacol Exp Ther. 2008 Feb;324(2):463-74 [18006692] Peptides. 2004 Mar;25(3):511-20 [15134870] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.109.154245 ER - TY - JOUR T1 - In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland. AN - 67664872; 19427376 AB - Systemic lipopolysaccharide (LPS) administration induces an innate immune response and stimulates the hypothalamic-pituitary-adrenal axis. We studied Angiotensin II AT(1) receptor participation in the LPS effects with focus on the pituitary gland. LPS (50 microg/kg, i.p.) enhanced, 3h after administration, gene expression of pituitary CD14 and that of Angiotensin II AT(1A) receptors in pituitary and hypothalamic paraventricular nucleus (PVN); stimulated ACTH and corticosterone release; decreased pituitary CRF(1) receptor mRNA and increased all plasma and pituitary pro-inflammatory factors studied. The AT(1) receptor blocker (ARB) candesartan (1mg/kg/day, s.c. daily for 3 days before LPS) blocked pituitary and PVN AT(1) receptors, inhibited LPS-induced ACTH but not corticosterone secretion and decreased LPS-induced release of TNF-alpha, IL-1beta and IL-6 to the circulation. The ARB reduced LPS-induced pituitary gene expression of IL-6, LIF, iNOS, COX-2 and IkappaB-alpha; and prevented LPS-induced increase of nNOS/eNOS activity. The ARB did not affect LPS-induced TNF-alpha and IL-1beta gene expression, IL-6 or IL-1beta protein content or LPS-induced decrease of CRF(1) receptors. When administered alone, the ARB increased basal plasma corticosterone levels and basal PGE(2) mRNA in pituitary. Our results demonstrate that the pituitary gland is a target for systemically administered LPS. AT(1) receptor activity is necessary for the complete pituitary response to LPS and is limited to specific pro-inflammatory pathways. There is a complementary and complex influence of the PVN and circulating cytokines on the initial pituitary response to LPS. Our findings support the proposal that ARBs may be considered for the treatment of inflammatory conditions. JF - Brain, behavior, and immunity AU - Sánchez-Lemus, Enrique AU - Benicky, Julius AU - Pavel, Jaroslav AU - Saavedra, Juan M AD - Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. sancheze@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 945 EP - 957 VL - 23 IS - 7 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Benzimidazoles KW - Cytokines KW - Lipopolysaccharides KW - RNA, Messenger KW - Receptor, Angiotensin, Type 1 KW - Tetrazoles KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Dinoprostone KW - K7Q1JQR04M KW - candesartan KW - S8Q36MD2XX KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Corticosterone -- secretion KW - Animals KW - Analysis of Variance KW - Benzimidazoles -- pharmacology KW - RNA, Messenger -- physiology KW - Inflammation -- drug therapy KW - Inflammation -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology KW - Autoradiography KW - Radioimmunoassay KW - Rats KW - Tetrazoles -- pharmacology KW - Paraventricular Hypothalamic Nucleus -- metabolism KW - In Situ Hybridization KW - Lipopolysaccharides -- immunology KW - Corticosterone -- blood KW - Rats, Wistar KW - Lipopolysaccharides -- toxicity KW - Enzyme-Linked Immunosorbent Assay KW - Inflammation -- metabolism KW - Dinoprostone -- genetics KW - Male KW - Hypothalamo-Hypophyseal System -- physiology KW - Cytokines -- blood KW - Hypothalamo-Hypophyseal System -- drug effects KW - Cytokines -- genetics KW - Adrenocorticotropic Hormone -- secretion KW - Receptor, Angiotensin, Type 1 -- immunology KW - Pituitary-Adrenal System -- metabolism KW - Hypothalamo-Hypophyseal System -- metabolism KW - Receptor, Angiotensin, Type 1 -- metabolism KW - Pituitary-Adrenal System -- drug effects KW - Pituitary-Adrenal System -- physiology KW - Adrenocorticotropic Hormone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67664872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=In+vivo+Angiotensin+II+AT1+receptor+blockade+selectively+inhibits+LPS-induced+innate+immune+response+and+ACTH+release+in+rat+pituitary+gland.&rft.au=S%C3%A1nchez-Lemus%2C+Enrique%3BBenicky%2C+Julius%3BPavel%2C+Jaroslav%3BSaavedra%2C+Juan+M&rft.aulast=S%C3%A1nchez-Lemus&rft.aufirst=Enrique&rft.date=2009-10-01&rft.volume=23&rft.issue=7&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=1090-2139&rft_id=info:doi/10.1016%2Fj.bbi.2009.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-28 N1 - Date created - 2009-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroimmunomodulation. 2006;13(3):170-8 [17183192] Brain Res. 2007 Apr 20;1142:92-9 [17306778] Int J Exp Pathol. 2007 Apr;88(2):85-94 [17408451] Acta Biomed. 2007;78 Suppl 1:231-47 [17465337] Stress. 2007 Jun;10(2):185-93 [17514587] Neuroimmunomodulation. 2006;13(5-6):257-67 [17709947] Front Biosci. 2008;13:1698-710 [17981661] J Neuroendocrinol. 2008 Jan;20(1):1-70 [18081553] Nat Rev Neurosci. 2008 Jan;9(1):46-56 [18073775] Endocrinology. 2008 May;149(5):2283-92 [18187539] Endocr J. 2008 May;55(2):285-90 [18323674] Cytokine. 2008 May;42(2):145-51 [18304834] Trends Pharmacol Sci. 2008 Jul;29(7):367-74 [18579222] Hypertension. 2008 Oct;52(4):679-86 [18768402] Endocrinology. 2008 Oct;149(10):5177-88 [18556352] Crit Rev Immunol. 2008;28(4):281-99 [19166381] Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R208-16 [19073907] Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1376-84 [19225144] Nat Immunol. 2005 Dec;6(12):1198-205 [16369559] Endocrinology. 1999 Dec;140(12):5971-81 [10579365] Endocr Rev. 2000 Jun;21(3):313-45 [10857556] Cytokine. 2000 May;12(5):423-31 [10857755] Brain Res. 2000 Jul 14;871(1):29-38 [10882779] Endocrinology. 2000 Dec;141(12):4457-65 [11108255] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8891-6 [11438713] J Neuroendocrinol. 2001 Aug;13(8):711-23 [11489088] Endocrinology. 2001 Sep;142(9):3880-9 [11517166] J Neuroendocrinol. 2001 Nov;13(11):942-50 [11737552] Neuroendocrinology. 2002 Apr;75(4):227-40 [11979053] Cell. 2002 Apr;109 Suppl:S81-96 [11983155] Cell Mol Neurobiol. 2002 Jun;22(3):315-33 [12469873] Brain Behav Immun. 2003 Feb;17(1):13-9 [12615045] Hypertension. 2003 Apr;41(4):984-90 [12642505] Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G414-23 [12686508] J Neuroimmunol. 2003 Sep;142(1-2):86-92 [14512167] Neuroimmunomodulation. 2004;11(1):1-9 [14557673] Peptides. 2004 Mar;25(3):319-29 [15134857] Stroke. 2004 Jul;35(7):1726-31 [15143297] Toxicology. 2004 Sep 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J. 1996 Dec;10(14):1607-13 [9002552] Endocr Rev. 1997 Apr;18(2):206-28 [9101137] Am J Physiol. 1997 Jul;273(1 Pt 1):E156-63 [9252492] J Neuroendocrinol. 1998 Jan;10(1):67-72 [9510060] J Neuroimmunol. 1998 Jun 15;86(2):134-41 [9663558] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10966-71 [9724813] Brain Res. 1998 Aug 17;802(1-2):189-97 [9748570] Endocrinology. 1999 Jan;140(1):472-7 [9886859] J Neuropathol Exp Neurol. 1999 Jan;58(1):61-77 [10068315] J Neuroendocrinol. 1999 Feb;11(2):115-20 [10048466] Endocrinology. 2005 Jan;146(1):35-43 [15388650] Endocrinology. 2005 Jan;146(1):33-4 [15601904] Curr Opin Crit Care. 2004 Dec;10(6):461-7 [15616387] Endocrinology. 2005 Mar;146(3):1398-402 [15564329] J Cereb Blood Flow Metab. 2005 Jul;25(7):878-86 [15729290] Eur J Endocrinol. 2005 Jul;153(1):1-12 [15994739] J Hepatol. 2005 Aug;43(2):317-23 [15964094] Curr Opin Nephrol Hypertens. 2006 Mar;15(2):152-8 [16481882] J Hypertens Suppl. 2006 Mar;24(1):S131-7 [16601566] Mol Endocrinol. 2006 May;20(5):953-70 [16141358] Neuropsychopharmacology. 2006 Jun;31(6):1123-34 [16205776] Physiol Rev. 2006 Jul;86(3):747-803 [16816138] Mini Rev Med Chem. 2006 Aug;6(8):945-51 [16918500] Curr Pharm Des. 2006;12(27):3509-19 [17017944] Brain Behav Immun. 2007 Feb;21(2):153-60 [17088043] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbi.2009.04.012 ER - TY - JOUR T1 - Pesticides and myocardial infarction incidence and mortality among male pesticide applicators in the Agricultural Health Study. AN - 67664601; 19700503 AB - Acute organophosphate and carbamate pesticide poisonings result in adverse cardiac outcomes. The cardiac effects of chronic low-level pesticide exposure have not been studied. The authors analyzed self-reported lifetime use of pesticides reported at enrollment (1993-1997) and myocardial infarction mortality through 2006 and self-reported nonfatal myocardial infarction through 2003 among male pesticide applicators in the Agricultural Health Study. Using proportional hazard models, the authors estimated the association between lifetime use of 49 pesticides and fatal and nonfatal myocardial infarction. There were 476 deaths from myocardial infarction among 54,069 men enrolled in the study and 839 nonfatal myocardial infarctions among the 32,024 participants who completed the follow-up interview. Fatal and nonfatal myocardial infarctions were associated with commonly reported risk factors, including age and smoking. There was little evidence of an association between having used pesticides, individually or by class, and myocardial infarction mortality (e.g., insecticide hazard ratio (HR) = 0.91, 95% confidence interval (CI): 0.67, 1.24; herbicide HR = 0.74, 95% CI: 0.49, 1.10) or nonfatal myocardial infarction incidence (e.g., insecticide HR = 0.85, 95% CI: 0.66, 1.09; herbicide HR = 0.91, 95% CI: 0.61, 1.36). There was no evidence of a dose response with any pesticide measure. In a population with low risk for myocardial infarction, the authors observed little evidence of increased risk of myocardial infarction mortality or nonfatal myocardial infarction associated with the occupational use of pesticides. JF - American journal of epidemiology AU - Mills, Katherine T AU - Blair, Aaron AU - Freeman, Laura E Beane AU - Sandler, Dale P AU - Hoppin, Jane A AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709-2233, USA. Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 892 EP - 900 VL - 170 IS - 7 KW - Pesticides KW - 0 KW - Index Medicus KW - Risk KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Proportional Hazards Models KW - Myocardial Infarction -- mortality KW - Agricultural Workers' Diseases -- mortality KW - Myocardial Infarction -- chemically induced KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Pesticides -- adverse effects KW - Myocardial Infarction -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67664601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Pesticides+and+myocardial+infarction+incidence+and+mortality+among+male+pesticide+applicators+in+the+Agricultural+Health+Study.&rft.au=Mills%2C+Katherine+T%3BBlair%2C+Aaron%3BFreeman%2C+Laura+E+Beane%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A&rft.aulast=Mills&rft.aufirst=Katherine&rft.date=2009-10-01&rft.volume=170&rft.issue=7&rft.spage=892&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp214 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-06 N1 - Date created - 2009-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Epidemiol. 2001 Feb;54(2):121-6 [11166526] Heart. 1997 May;77(5):461-4 [9196418] Circulation. 2001 Jun 12;103(23):2810-5 [11401937] Epidemiology. 2002 Jan;13(1):94-9 [11805592] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Occup Environ Med. 2003 Aug;60(8):e1 [12883028] JAMA. 1982 Sep 3;248(9):1073-6 [7109199] Am J Epidemiol. 1986 May;123(5):894-900 [3962971] Occup Environ Med. 1997 Jul;54(7):466-9 [9282121] Ann Epidemiol. 1998 Jan;8(1):64-74 [9465996] Occup Environ Med. 1999 Jan;56(1):14-21 [10341741] Ann Epidemiol. 2005 Apr;15(4):279-85 [15780775] Environ Health Perspect. 2005 Jun;113(6):756-61 [15929900] Toxicol Sci. 2005 Oct;87(2):385-90 [16033992] Environ Health Perspect. 2006 Feb;114(2):186-93 [16451853] Crit Rev Toxicol. 2007 Mar;37(3):279-85 [17453935] Occup Environ Med. 2007 Aug;64(8):515-9 [17303673] Chest. 1993 Feb;103(2):576-82 [8432156] Environ Health Perspect. 1993 Apr;100:39-44 [8354180] Epidemiology. 1995 Jan;6(1):67-9 [7888449] Int J Epidemiol. 1997 Feb;26(1):47-57 [9126502] Eur Respir J. 2001 Apr;17(4):733-46 [11401072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp214 ER - TY - JOUR T1 - Plasma microRNAs: a potential biomarker for colorectal cancer? AN - 67651612; 19749133 JF - Gut AU - Schetter, Aaron J AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1318 EP - 1319 VL - 58 IS - 10 KW - Biomarkers, Tumor KW - 0 KW - MicroRNAs KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Colonoscopy KW - Humans KW - Early Detection of Cancer KW - Colorectal Neoplasms -- diagnosis KW - Occult Blood KW - MicroRNAs -- blood KW - Biomarkers, Tumor -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67651612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Plasma+microRNAs%3A+a+potential+biomarker+for+colorectal+cancer%3F&rft.au=Schetter%2C+Aaron+J%3BHarris%2C+Curtis+C&rft.aulast=Schetter&rft.aufirst=Aaron&rft.date=2009-10-01&rft.volume=58&rft.issue=10&rft.spage=1318&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=1468-3288&rft_id=info:doi/10.1136%2Fgut.2009.176875 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-13 N1 - Date created - 2009-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Gut. 2009 Oct;58(10):1375-81 [19201770] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/gut.2009.176875 ER - TY - JOUR T1 - Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice. AN - 67608628; 19559060 AB - Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old, were injected with saline or METH (i.p., 7.5 mg/kg x 4 times, every 2 h). Behavior and neurotoxic effects were assessed at 10 days, 3 and 5 months following drug treatment. METH administration caused marked decreases in DA levels in the mouse striatum and cortex at 10 days post-drug. However, METH did not induce any changes in novelty-induced locomotor activity. At 3 and 5 months after treatment METH-exposed mice showed significant recovery of DA levels in the striatum and cortex. In contrast, these animals demonstrated significant decreases in locomotor activity at 5 months in comparison to aged-matched control mice. Further assessment of METH toxicity using TUNEL staining showed that the drug induced increased cell death in the striatum and cortex at 3 days after administration. Taken together, these data suggest that delayed deficits in novelty-induced locomotor activity observed in METH-exposed animals are not due to neurodegeneration of DA terminals but to combined effects of METH and age-dependent dysfunction of non-DA intrinsic striatal and/or corticostriatal neurons. JF - Neuroscience research AU - Krasnova, Irina N AU - Hodges, Amber B AU - Ladenheim, Bruce AU - Rhoades, Raina AU - Phillip, Crystal G AU - Cesena, Angela AU - Ivanova, Ekaterina AU - Hohmann, Christine F AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD 21224, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 160 EP - 165 VL - 65 IS - 2 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Aging -- metabolism KW - Animals KW - Age Factors KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Nerve Degeneration -- physiopathology KW - Corpus Striatum -- metabolism KW - Presynaptic Terminals -- pathology KW - Nerve Degeneration -- chemically induced KW - Disease Models, Animal KW - Mice KW - Mice, Inbred BALB C KW - Presynaptic Terminals -- metabolism KW - Cerebral Cortex -- physiopathology KW - Presynaptic Terminals -- drug effects KW - Corpus Striatum -- physiopathology KW - Nerve Degeneration -- metabolism KW - Central Nervous System Stimulants -- toxicity KW - Corpus Striatum -- drug effects KW - Male KW - Brain -- physiopathology KW - Exploratory Behavior -- drug effects KW - Brain -- drug effects KW - Exploratory Behavior -- physiology KW - Dopamine -- metabolism KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Brain -- metabolism KW - Methamphetamine -- toxicity KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67608628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+research&rft.atitle=Methamphetamine+treatment+causes+delayed+decrease+in+novelty-induced+locomotor+activity+in+mice.&rft.au=Krasnova%2C+Irina+N%3BHodges%2C+Amber+B%3BLadenheim%2C+Bruce%3BRhoades%2C+Raina%3BPhillip%2C+Crystal+G%3BCesena%2C+Angela%3BIvanova%2C+Ekaterina%3BHohmann%2C+Christine+F%3BCadet%2C+Jean+Lud&rft.aulast=Krasnova&rft.aufirst=Irina&rft.date=2009-10-01&rft.volume=65&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Neuroscience+research&rft.issn=1872-8111&rft_id=info:doi/10.1016%2Fj.neures.2009.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-13 N1 - Date created - 2009-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 2000;95(1):113-7 [10619467] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] J Pharmacol Exp Ther. 2001 Feb;296(2):520-7 [11160639] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Am J Psychiatry. 2001 Aug;158(8):1206-14 [11481152] Brain Res Mol Brain Res. 2001 Sep 10;93(1):64-9 [11532339] Ann N Y Acad Sci. 2001 Apr;928:316-26 [11795523] Int J Geriatr Psychiatry. 2002 Apr;17(4):359-70 [11994891] Mol Pharmacol. 2002 Nov;62(5):993-1000 [12391261] Arch Gen Psychiatry. 2003 Mar;60(3):303-10 [12622664] Synapse. 2003 Aug;49(2):89-96 [12740864] Behav Pharmacol. 2003 May;14(3):199-206 [12799521] Am J Psychiatry. 2003 Sep;160(9):1699-701 [12944350] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11035-40 [12958210] Brain. 2004 Feb;127(Pt 2):363-70 [14645148] Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):629-38 [15118809] J Neurosci. 2004 Jun 30;24(26):6028-36 [15229250] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] Science. 1989 Sep 29;245(4925):1511-3 [2781295] Can J Psychol. 1990 Jun;44(2):253-75 [2116937] J Pharmacol Exp Ther. 1992 Nov;263(2):617-26 [1432692] Synapse. 1993 Feb;13(2):179-85 [7680495] Ann N Y Acad Sci. 1994 May 31;719:129-35 [8010587] Nat Med. 1996 Jun;2(6):699-703 [8640565] Psychiatry Res. 1996 May 31;67(1):11-6 [8797238] J Neurosci. 1996 Oct 15;16(20):6579-91 [8815934] Brain Res. 1997 Aug 22;766(1-2):113-20 [9359594] Neurobiol Dis. 1997;4(3-4):247-53 [9361301] Am J Psychiatry. 1998 Mar;155(3):344-9 [9501743] J Neurosci. 1998 May 1;18(9):3470-9 [9547254] Pharmacol Biochem Behav. 1998 Sep;61(1):35-44 [9715805] Neuroscience. 1999;93(1):243-51 [10430488] Neurobiol Aging. 2005 Apr;26(4):521-30 [15653180] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] FASEB J. 2005 May;19(7):851-3 [15731293] Pharmacol Biochem Behav. 2005 May;81(1):198-204 [15894079] Neuropsychopharmacology. 2005 Jun;30(6):1128-37 [15688084] Psychopharmacology (Berl). 2007 Nov;194(4):517-25 [17619858] Neuropsychol Rev. 2007 Sep;17(3):275-97 [17694436] Synapse. 2008 Feb;62(2):91-100 [17992686] Behav Brain Res. 2008 Mar 5;187(2):462-72 [18036673] Neuropsychopharmacology. 2008 May;33(6):1453-63 [17637607] J Neurochem. 2008 Jun;105(5):1861-72 [18248617] DNA Repair (Amst). 2008 Jul 1;7(7):1087-97 [18458001] Psychopharmacology (Berl). 2008 Sep;199(4):637-50 [18509623] Mov Disord. 2008;23 Suppl 3:S534-47 [18781680] Neuroscience. 2008 Oct 28;156(4):830-40 [18817851] Neuroscience. 2009 Jan 23;158(2):558-69 [19007862] Synapse. 2009 Apr;63(4):282-90 [19116949] Neurobiol Dis. 2009 Mar;33(3):459-66 [19110059] Brain Res Rev. 2009 May;60(2):379-407 [19328213] Neuropsychopharmacology. 2005 Dec;30(12):2125-34 [16123755] Psychopharmacology (Berl). 2006 Apr;185(3):327-38 [16518646] Biol Psychiatry. 2006 May 15;59(10):908-18 [16581032] Neuroscience. 2006 Jun 30;140(2):607-22 [16650608] Behav Brain Res. 2006 Sep 15;172(1):39-45 [16712969] Ann N Y Acad Sci. 2006 Aug;1074:225-33 [17105919] Eur J Pharmacol. 2007 Mar 15;559(1):46-54 [17239369] Neurotox Res. 2007 Feb;11(2):107-30 [17449454] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] Aging Cell. 2007 Jun;6(3):275-84 [17465981] J Neurosci. 2007 Aug 15;27(33):8816-25 [17699663] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neures.2009.06.007 ER - TY - JOUR T1 - Long-term impact of cancer care on activities of daily living: are we causing our sarcoma survivors to grow up too quickly? AN - 67605981; 19588522 JF - Pediatric blood & cancer AU - Merchant, Melinda S AD - Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1104, USA. merchanm@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 531 EP - 532 VL - 53 IS - 4 KW - Index Medicus KW - Humans KW - Cranial Irradiation -- adverse effects KW - Sarcoma -- psychology KW - Sarcoma -- mortality KW - Activities of Daily Living KW - Survivors -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67605981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Long-term+impact+of+cancer+care+on+activities+of+daily+living%3A+are+we+causing+our+sarcoma+survivors+to+grow+up+too+quickly%3F&rft.au=Merchant%2C+Melinda+S&rft.aulast=Merchant&rft.aufirst=Melinda&rft.date=2009-10-01&rft.volume=53&rft.issue=4&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=1545-5017&rft_id=info:doi/10.1002%2Fpbc.22166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pediatr Blood Cancer. 2009 Oct;53(4):622-8 [19533662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pbc.22166 ER - TY - JOUR T1 - Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate. AN - 67588361; 19221751 AB - Chemoprotective effect of diphenylmethyl selenocyanate against cyclophosphamide (CP) induced cellular toxicity and antitumor efficacy was evaluated in mice bearing Ehrlich ascites carcinoma. Diphenylmethyl selenocyanate (3 mg/kg.b.w.) was administered orally and CP was given intraperitoneally (25 mg/kg.b.w). The effects were observed on the level of lipid peroxidation, antioxidant enzymes status, serum transaminase (ALT, AST) activity, hematological profile, transplantable murine tumor growth, apoptosis induction in tumor cells, and life span of tumor bearing hosts. The selenium compound restored the levels of antioxidant enzymes system, decreased the level of lipid peroxidation and serum transaminase activity. Hematological profile reverted to near normal level after selenium compound treatment. Treatment with the selenium compound also resulted in significant tumor growth regression along with significant upregulation of apoptosis, increased in mean survival time and life span of tumor bearing host. Results clearly indicate that diphenylmethyl selenocyanate has the potential to reduce the cellular toxicity of CP at the same time improving its antitumor efficacy. JF - Cancer chemotherapy and pharmacology AU - Chakraborty, Pramita AU - Sk, Ugir Hossain AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 971 EP - 980 VL - 64 IS - 5 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Antioxidants KW - Organoselenium Compounds KW - diphenylmethyl selenocyanate KW - Cyclophosphamide KW - 8N3DW7272P KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Alanine Transaminase -- metabolism KW - Glutathione -- metabolism KW - Glutathione Transferase -- metabolism KW - Lipid Peroxidation -- drug effects KW - Superoxide Dismutase -- metabolism KW - Mice KW - Blood Cell Count KW - Catalase -- metabolism KW - Aspartate Aminotransferases -- metabolism KW - Antioxidants -- metabolism KW - Glutathione Peroxidase -- metabolism KW - Apoptosis -- drug effects KW - Drug Synergism KW - Male KW - Survival Analysis KW - Organoselenium Compounds -- pharmacology KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Carcinoma, Ehrlich Tumor -- pathology KW - Carcinoma, Ehrlich Tumor -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67588361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Chemoprotection+and+enhancement+of+cancer+chemotherapeutic+efficacy+of+cyclophosphamide+in+mice+bearing+Ehrlich+ascites+carcinoma+by+diphenylmethyl+selenocyanate.&rft.au=Chakraborty%2C+Pramita%3BSk%2C+Ugir+Hossain%3BBhattacharya%2C+Sudin&rft.aulast=Chakraborty&rft.aufirst=Pramita&rft.date=2009-10-01&rft.volume=64&rft.issue=5&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-0950-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-0950-8 ER - TY - JOUR T1 - Depressive Symptoms and Clinical Status During the Treatment of Adolescent Suicide Attempters (TASA) Study AN - 57350908; 201001260 AB - Objective: To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide. Method: Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Children's Depression Rating Scale-Revised (CDRS-R) score of 36 or higher, entered a 6-month treatment with antidepressant medication, cognitive-behavioral therapy focused on suicide prevention, or their combination (Comb), at five academic sites. Treatment assignment could be either random or chosen by study participants. Intent-to-treat, mixed effects regression models of depression and other relevant ratings were estimated. Improvement and remission rates were computed with the last observation carried forward. Results: Most patients (n = 104 or 84%) chose treatment assignment, and overall, three fourths (n = 93) received Comb. In Comb, CDRS-R declined from a baseline adjusted mean of 49.6 (SD 12.3) to 38.3 (8.0) at weak 12 and to 27.0 (10.1) at week 24 (p < .0001), with a Clinical Global Impression-defined improvement rate of 58.0% at week 12 and 72.2% at week 24 and a remission (CDRS-R =28) rate of 32.5% at week 12 and 50.0% at week 24. The CDRS-R and the Scale for Suicidal Ideation scores were correlated at baseline (r= 0.43, p< .0001) and declined in parallel. Conclusions: When vigorously treated with a combination of medication and psychotherapy, adolescents with depression who have recently attempted suicide show rates of improvement and remission of depression that seem comparable to those observed in nonsuicidal adolescents with depression. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AU - Brent, David A AU - Greenhill, Laurence L AU - Emslie, Graham AU - Wells, Karen AU - Walkup, John T AU - Stanley, Barbara AU - Bukstein, Oscar AU - Kennard, Betsy D AU - Compton, Scott AU - Coffey, Barbara AU - Cwik, Mary F AU - Posner, Kelly AU - Wagner, Ann AU - March, John S AU - Riddle, Mark AU - Goldstein, Tina AU - Curry, John AU - Capasso, Lisa AU - Mayes, Taryn AU - Shen, Sa AU - Gugga, S Sonia AU - Turner, J Blake AU - Barnett, Shannon AU - Zelazny, Jamie AD - National Institute of Mental Health, Room 7147,6001 Executive Blvd, Bethesda, MD 20892-9633 Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 997 EP - 1004 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 10 SN - 0890-8567, 0890-8567 KW - adolescents, suicide, depression, treatment KW - Depressive personality disorders KW - Suicidal behaviour KW - Depression KW - Remission KW - Treatment KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57350908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Depressive+Symptoms+and+Clinical+Status+During+the+Treatment+of+Adolescent+Suicide+Attempters+%28TASA%29+Study&rft.au=Vitiello%2C+Benedetto%3BBrent%2C+David+A%3BGreenhill%2C+Laurence+L%3BEmslie%2C+Graham%3BWells%2C+Karen%3BWalkup%2C+John+T%3BStanley%2C+Barbara%3BBukstein%2C+Oscar%3BKennard%2C+Betsy+D%3BCompton%2C+Scott%3BCoffey%2C+Barbara%3BCwik%2C+Mary+F%3BPosner%2C+Kelly%3BWagner%2C+Ann%3BMarch%2C+John+S%3BRiddle%2C+Mark%3BGoldstein%2C+Tina%3BCurry%2C+John%3BCapasso%2C+Lisa%3BMayes%2C+Taryn%3BShen%2C+Sa%3BGugga%2C+S+Sonia%3BTurner%2C+J+Blake%3BBarnett%2C+Shannon%3BZelazny%2C+Jamie&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2009-10-01&rft.volume=48&rft.issue=10&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e3181b5db66 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-01-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Adolescents; Remission; Suicidal behaviour; Treatment; Depressive personality disorders DO - http://dx.doi.org/10.1097/CHI.0b013e3181b5db66 ER - TY - JOUR T1 - School Bullying Among Adolescents in the United States: Physical, Verbal, Relational, and Cyber AN - 57314842; 200928753 AB - Purpose Four forms of school bullying behaviors among US adolescents and their association with sociodemographic characteristics, parental support, and friends were examined. Methods Data were obtained from the Health Behavior in School-Aged Children (HBSC) 2005 Survey, a nationally representative sample of grades 6-10 (N = 7,182). The revised Olweus Bully/Victim Questionnaire was used to measure physical, verbal, and relational forms of bullying. Two items were added using the same format to measure cyber bullying. For each form, four categories were created: bully, victim, bully-victim, and not involved. Multinomial logistic regressions were applied, with sociodemographic variables, parental support, and number of friends as predictors. Results Prevalence rates of having bullied others or having been bullied at school for at least once in the last 2 months were 20.8% physically, 53.6% verbally, 51.4% socially, or 13.6% electronically. Boys were more involved in physical or verbal bullying, whereas girls were more involved in relational bullying. Boys were more likely to be cyber bullies, whereas girls were more likely to be cyber victims. African-American adolescents were involved in more bullying (physical, verbal, or cyber) but less victimization (verbal or relational). Higher parental support was associated with less involvement across all forms and classifications of bullying. Having more friends was associated with more bullying and less victimization for physical, verbal, and relational forms but was not associated with cyber bullying. Conclusions Parental support may protect adolescents from all four forms of bullying. Friends associate differentially with traditional and cyber bullying. Results indicate that cyber bullying is a distinct nature from that of traditional bullying. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wang, Jing AU - Iannotti, Ronald J AU - Nansel, Tonja R AD - National Institutes of Health, Bethesda, Maryland wangji2@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 368 EP - 375 PB - Elsevier, New York NY VL - 45 IS - 4 SN - 1054-139X, 1054-139X KW - School bullying Cyber bullying Relational bullying Parental support Peers Sociodemographic characteristics KW - Victims KW - Parental support KW - Friends KW - Victimization KW - Adolescents KW - Bullying KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=School+Bullying+Among+Adolescents+in+the+United+States%3A+Physical%2C+Verbal%2C+Relational%2C+and+Cyber&rft.au=Wang%2C+Jing%3BIannotti%2C+Ronald+J%3BNansel%2C+Tonja+R&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2009-10-01&rft.volume=45&rft.issue=4&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2009.03.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Bullying; Adolescents; Friends; Parental support; Victims; Victimization DO - http://dx.doi.org/10.1016/j.jadohealth.2009.03.021 ER - TY - JOUR T1 - Review: Smoking and Smoking Cessation in Disadvantaged Women: Assessing Genetic Contributions AN - 57302660; 200927988 AB - Abundant evidence from family, adoption and twin studies points to large genetic contributions to individual differences in vulnerability to develop dependence on one or more addictive substances, including tobacco. Twin data suggests that much of this genetic vulnerability is shared by individuals who are dependent on a variety of addictive substances. Interestingly, some twin data also supports substantial differences in the apparent heritability of nicotine dependence in women as environmental conditions become more permissive for their smoking. In addition, twin studies also support the idea that ability to quit smoking displays substantial heritability, and that this heritable influence overlaps partially with genetic influences on nicotine dependence. Candidate gene molecular genetic studies and genome wide association studies of substance dependence and ability to quit smoking each document apparent polygenic influences that identify lists of genes that display partial overlap, as expected from classical genetic studies. More of these genes are expressed in the brain than would be anticipated by chance. These lists of genes overlap significantly with those identified in molecular genetic studies of individual differences in cognitive abilities, frontal lobe brain volumes as well as personality and psychiatric phenotypes. Though most available genome wide association data do not separate results by gender, it may be notable that few of these genes lie on sex chromosomes. These data provide a substrate to improve understanding of nicotine dependence, the ability to quit smoking, the potential for less permissive environments to restrict the expression of genetic influences on smoking and the possibility that brain features that underlie phenotypes such as individual differences in cognitive abilities might interact with environmental features that are especially prominent for disadvantaged women to provide special circumstances that should be considered in prevention and treatment efforts to reduce smoking. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Uhl, George R AU - Drgon, Tomas AU - Li, Chuan-Yun AU - Johnson, Catherine AU - Liu, Qing-Rong AD - Molecular Neurobiology Branch, NIH-IRP (NIDA), Baltimore, MD guhl@intra.nida.nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - S58 EP - S63 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 104 IS - Supplement 1 SN - 0376-8716, 0376-8716 KW - Genetics, Genome wide association, Tobacco, Dependence KW - Smoking KW - Individual differences KW - Genetic factors KW - Genes KW - Cessation KW - Drug dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57302660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Review%3A+Smoking+and+Smoking+Cessation+in+Disadvantaged+Women%3A+Assessing+Genetic+Contributions&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BLi%2C+Chuan-Yun%3BJohnson%2C+Catherine%3BLiu%2C+Qing-Rong&rft.aulast=Uhl&rft.aufirst=George&rft.date=2009-10-01&rft.volume=104&rft.issue=Supplement+1&rft.spage=S58&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.03.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-11-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Genetic factors; Smoking; Genes; Cessation; Drug dependency; Individual differences DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.03.012 ER - TY - CPAPER T1 - Cancer and Treatment-Related Diarrhea T2 - Fifth Chicago Supportive Oncology Conference AN - 42497919; 5443672 JF - Fifth Chicago Supportive Oncology Conference AU - Brell, Joanna Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Cancer KW - Diarrhea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42497919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+Chicago+Supportive+Oncology+Conference&rft.atitle=Cancer+and+Treatment-Related+Diarrhea&rft.au=Brell%2C+Joanna&rft.aulast=Brell&rft.aufirst=Joanna&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+Chicago+Supportive+Oncology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.supportiveoncology.net/chicago/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defensive Dining: Eating for Cancer Prevention T2 - Fifth Chicago Supportive Oncology Conference AN - 42492769; 5443648 JF - Fifth Chicago Supportive Oncology Conference AU - Emenaker, Nancy Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Cancer KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42492769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+Chicago+Supportive+Oncology+Conference&rft.atitle=Defensive+Dining%3A+Eating+for+Cancer+Prevention&rft.au=Emenaker%2C+Nancy&rft.aulast=Emenaker&rft.aufirst=Nancy&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+Chicago+Supportive+Oncology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.supportiveoncology.net/chicago/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Light Scattering Measurement of Molecular Chaperone Alpha Crystallin Proteins in Young Lenses: Possible Roles of Oxidative Stress and Genetic Variability in Cataract Formation. T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42475949; 5431029 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Datiles III, Manuel AU - Ansari, Rafat AU - Vitale, Susan AU - Zigler, J AU - Ferris III, Frederick Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Light scattering KW - Oxidative stress KW - Cataracts KW - Crystallin KW - Chaperones KW - Genetic isolation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42475949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=Dynamic+Light+Scattering+Measurement+of+Molecular+Chaperone+Alpha+Crystallin+Proteins+in+Young+Lenses%3A+Possible+Roles+of+Oxidative+Stress+and+Genetic+Variability+in+Cataract+Formation.&rft.au=Datiles+III%2C+Manuel%3BAnsari%2C+Rafat%3BVitale%2C+Susan%3BZigler%2C+J%3BFerris+III%2C+Frederick&rft.aulast=Datiles+III&rft.aufirst=Manuel&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Multicolor Imaging Using Dehalogenase-Based Protein-Tag (Halo-Tag) System as a Reporter T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42474873; 5430974 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Kobayashi, Hisataka AU - Kosaka, Nobuyuki AU - Ogawa, Mikako AU - Karassina, Natasha AU - Corona, Cesear AU - McDougall, Mark AU - Lynch, David AU - Hoyt, Clifford AU - Levenson, Richard AU - . Los, Georgyi AU - Choyke, Peter Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42474873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=In+Vivo+Multicolor+Imaging+Using+Dehalogenase-Based+Protein-Tag+%28Halo-Tag%29+System+as+a+Reporter&rft.au=Kobayashi%2C+Hisataka%3BKosaka%2C+Nobuyuki%3BOgawa%2C+Mikako%3BKarassina%2C+Natasha%3BCorona%2C+Cesear%3BMcDougall%2C+Mark%3BLynch%2C+David%3BHoyt%2C+Clifford%3BLevenson%2C+Richard%3B.+Los%2C+Georgyi%3BChoyke%2C+Peter&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescence Lifetime Imaging of Activatable Target Specific Molecular Probes T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42472738; 5430986 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Alford, Raphael AU - Ogawa, Mikako AU - Hassan, Moinuddin AU - Gandjbakhche, Amir AU - Choyke, Peter AU - Kobayashi, Hisataka Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Fluorescence KW - Fluorescent indicators KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42472738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=Fluorescence+Lifetime+Imaging+of+Activatable+Target+Specific+Molecular+Probes&rft.au=Alford%2C+Raphael%3BOgawa%2C+Mikako%3BHassan%2C+Moinuddin%3BGandjbakhche%2C+Amir%3BChoyke%2C+Peter%3BKobayashi%2C+Hisataka&rft.aulast=Alford&rft.aufirst=Raphael&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The "Image and Treat" Approach to Her-2 Positive Tumors: A Step toward Individualized Medicine T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42472293; 5431022 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Capala, Jacek Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Tumors KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42472293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=The+%22Image+and+Treat%22+Approach+to+Her-2+Positive+Tumors%3A+A+Step+toward+Individualized+Medicine&rft.au=Capala%2C+Jacek&rft.aulast=Capala&rft.aufirst=Jacek&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Multi-Photon Imaging in Vivo with Total Emission Detection (Ted) T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42471889; 5431079 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Combs, Christian Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Emissions KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42471889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=Improved+Multi-Photon+Imaging+in+Vivo+with+Total+Emission+Detection+%28Ted%29&rft.au=Combs%2C+Christian&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - H-Dimer Formation of Rhodamines: A Design of Activatable Optical Probes for in Vivo Molecular Imaging T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42471354; 5430972 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Ogawa, Mikako AU - Kosaka, Nobuyuki AU - Choyke, Peter AU - Kobayashi, Hisataka Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Probes KW - Imaging techniques KW - Rhodamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42471354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=H-Dimer+Formation+of+Rhodamines%3A+A+Design+of+Activatable+Optical+Probes+for+in+Vivo+Molecular+Imaging&rft.au=Ogawa%2C+Mikako%3BKosaka%2C+Nobuyuki%3BChoyke%2C+Peter%3BKobayashi%2C+Hisataka&rft.aulast=Ogawa&rft.aufirst=Mikako&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analysis of her2 Receptors Expression in Vivo by Nir Optical Imaging T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42470821; 5431019 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Chernomordik, Victor AU - Hassan, Moinuddin AU - Lee, Sang-Bong AU - Zielinski, Rafal AU - Gandjbakhche, Amir AU - Capala, Jacek Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Quantitative analysis KW - Imaging techniques KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42470821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=Quantitative+Analysis+of+her2+Receptors+Expression+in+Vivo+by+Nir+Optical+Imaging&rft.au=Chernomordik%2C+Victor%3BHassan%2C+Moinuddin%3BLee%2C+Sang-Bong%3BZielinski%2C+Rafal%3BGandjbakhche%2C+Amir%3BCapala%2C+Jacek&rft.aulast=Chernomordik&rft.aufirst=Victor&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maximizing Signals from in Vivo Multiphoton Microscopy: Non-Contact Total Emission Detection (Tedii) T2 - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AN - 42470785; 5431017 JF - NIH01: Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Benchside AU - Combs, Christian AU - Smirnov, Aleksandr AU - Luger-Hamer, M AU - Knutson, Jay AU - Balaban, Robert Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 KW - Microscopy KW - Emissions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42470785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.atitle=Maximizing+Signals+from+in+Vivo+Multiphoton+Microscopy%3A+Non-Contact+Total+Emission+Detection+%28Tedii%29&rft.au=Combs%2C+Christian%3BSmirnov%2C+Aleksandr%3BLuger-Hamer%2C+M%3BKnutson%2C+Jay%3BBalaban%2C+Robert&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2009-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NIH01%3A+Inter-Institute+Workshop+on+Optical+Diagnostic+and+Biophotonic+Methods+from+Bench+to+Benchside&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x33483&ID=x36222&redir=x36222.xml&conference_id=894611&event_ id=889644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Using relative utility curves to evaluate risk prediction AN - 37204204; 3901396 AB - Because many medical decisions are based on risk prediction models that are constructed from medical history and results of tests, the evaluation of these prediction models is important. This paper makes five contributions to this evaluation: the relative utility curve which gauges the potential for better prediction in terms of utilities, without the need for a reference level for one utility, while providing a sensitivity analysis for misspecification of utilities, the relevant region, which is the set of values of prediction performance that are consistent with the recommended treatment status in the absence of prediction, the test threshold, which is the minimum number of tests that would be traded for a true positive prediction in order for the expected utility to be non-negative, the evaluation of two-stage predictions that reduce test costs and connections between various measures of performance of prediction. An application involving the risk of cardiovascular disease is discussed. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Baker, S G AU - Cook, N R AU - Vickers, A AU - Kramer, B S AD - National Cancer Institute ; Brigham and Women's Hospital ; Memorial Sloan-Kettering Cancer Center ; National Institutes of Health, Bethesda Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 729 EP - 748 VL - 172 IS - 4 SN - 0964-1998, 0964-1998 KW - Sociology KW - Decision making KW - Medical care KW - Statistical data KW - Quantitative analysis KW - Statistical analysis KW - Decision analysis KW - Statistical methods KW - Heart disease KW - Risk theory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37204204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Using+relative+utility+curves+to+evaluate+risk+prediction&rft.au=Baker%2C+S+G%3BCook%2C+N+R%3BVickers%2C+A%3BKramer%2C+B+S&rft.aulast=Baker&rft.aufirst=S&rft.date=2009-10-01&rft.volume=172&rft.issue=4&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12224 971; 3321 971 6071 1542 11325; 11040 11035; 5796 3617 6220; 7875 5775 13521; 3322 6071 1542 11325; 12225 12233; 10530 3279 971 3286; 12228 10919 ER - TY - JOUR T1 - CA-074Me Protection against Anthrax Lethal Toxin AN - 21503265; 12510901 AB - Anthrax lethal toxin (LT) activates the NLRP1b (NALP1b) inflammasome and caspase-1 in macrophages from certain inbred mouse strains, but the mechanism by which this occurs is poorly understood. We report here that similar to several NLRP3 (NALP3, cryopyrin)-activating stimuli, LT activation of the NLRP1b inflammasome involves lysosomal membrane permeabilization (LMP) and subsequent cytoplasmic cathepsin B activity. CA-074Me, a potent cathepsin B inhibitor, protects LT-sensitive macrophages from cell death and prevents the activation of caspase-1. RNA interference knockdown of cathepsin B expression, however, cannot prevent LT-mediated cell death, suggesting that CA-074Me may also act on other cellular proteases released during LMP. CA-074Me appears to function downstream of LT translocation to the cytosol (as assessed by mitogen-activated protein kinase kinase cleavage), K+ effluxes, and proteasome activity. The initial increase in cytoplasmic activity of cathepsin B occurs at the same time or shortly before caspase-1 activation but precedes a larger-scale lysosomal destabilization correlated closely with cytolysis. We present results suggesting that LMP may be involved in the activation of the NLRP1b inflammasome. JF - Infection and Immunity AU - Newman, Zachary L AU - Leppla, Stephen H AU - Moayeri, Mahtab AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, mmoayeri@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 4327 EP - 4336 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 10 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Anthrax lethal toxin KW - Protein transport KW - MAP kinase KW - Cathepsin B KW - proteasomes KW - Potassium KW - Cell activation KW - Cell death KW - Cytolysis KW - Cytosol KW - RNA-mediated interference KW - Proteinase KW - Caspase-1 KW - Inbreeding KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21503265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=CA-074Me+Protection+against+Anthrax+Lethal+Toxin&rft.au=Newman%2C+Zachary+L%3BLeppla%2C+Stephen+H%3BMoayeri%2C+Mahtab&rft.aulast=Newman&rft.aufirst=Zachary&rft.date=2009-10-01&rft.volume=77&rft.issue=10&rft.spage=4327&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00730-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Protein transport; Anthrax lethal toxin; MAP kinase; Cathepsin B; proteasomes; Potassium; Cell activation; Cell death; Cytosol; Cytolysis; RNA-mediated interference; Inbreeding; Caspase-1; Proteinase DO - http://dx.doi.org/10.1128/IAI.00730-09 ER - TY - JOUR T1 - Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease AN - 21500136; 12510863 AB - Chronic granulomatous disease (CGD) patients are susceptible to life-threatening infections by the Burkholderia cepacia complex. We used leukocytes from CGD and healthy donors and compared cell association, invasion, and cytokine induction by Burkholderia multivorans strains. A CGD isolate, CGD1, showed higher cell association than that of an environmental isolate, Env1, which correlated with cell entry. All B. multivorans strains associated significantly more with cells from CGD patients than with those from healthy donors. Similar findings were observed with another CGD pathogen, Serratia marcescens, but not with Escherichia coli. In a mouse model of CGD, strain CGD1 was virulent while Env1 was avirulent. B. multivorans organisms were found in the spleens of CGD1-infected mice at levels that were 1,000 times higher than those found in Env1-infected mice, which was coincident with higher levels of the proinflammatory cytokine interleukin-1?. Taken together, these results may shed light on the unique susceptibility of CGD patients to specific pathogens. JF - Infection and Immunity AU - Zelazny, Adrian M AU - Ding, Li AU - Elloumi, Houda Z AU - Brinster, Lauren R AU - Benedetti, Fran AU - Czapiga, Meggan AU - Ulrich, Ricky L AU - Ballentine, Samuel J AU - Goldberg, Joanna B AU - Sampaio, Elizabeth P AU - Holland, Steven M AD - Laboratory of Clinical Infectious Diseases, azelazny@mail.nih.gov azelazny@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 4337 EP - 4344 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 10 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Animal models KW - Chronic granulomatous disease KW - Chronic infection KW - Cytokines KW - Inflammation KW - Interleukin 1 KW - Leukocytes KW - Pathogens KW - Spleen KW - Virulence KW - Burkholderia cepacia KW - Escherichia coli KW - Serratia marcescens KW - Burkholderia multivorans KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21500136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Virulence+and+Cellular+Interactions+of+Burkholderia+multivorans+in+Chronic+Granulomatous+Disease&rft.au=Zelazny%2C+Adrian+M%3BDing%2C+Li%3BElloumi%2C+Houda+Z%3BBrinster%2C+Lauren+R%3BBenedetti%2C+Fran%3BCzapiga%2C+Meggan%3BUlrich%2C+Ricky+L%3BBallentine%2C+Samuel+J%3BGoldberg%2C+Joanna+B%3BSampaio%2C+Elizabeth+P%3BHolland%2C+Steven+M&rft.aulast=Zelazny&rft.aufirst=Adrian&rft.date=2009-10-01&rft.volume=77&rft.issue=10&rft.spage=4337&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00259-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Virulence; Leukocytes; Chronic infection; Interleukin 1; Animal models; Spleen; Cytokines; Pathogens; Chronic granulomatous disease; Inflammation; Escherichia coli; Serratia marcescens; Burkholderia cepacia; Burkholderia multivorans DO - http://dx.doi.org/10.1128/IAI.00259-09 ER - TY - JOUR T1 - Borrelia burgdorferi Resistance to a Major Skin Antimicrobial Peptide Is Independent of Outer Surface Lipoprotein Content AN - 21475045; 12492354 AB - We hypothesize a potential role for Borrelia burgdorferi OspC in innate immune evasion at the initial stage of mammalian infection. We demonstrate that B. burgdorferi is resistant to high levels (>200 kg/ml) of cathelicidin and that this antimicrobial peptide exhibits limited binding to the spirochetal outer membrane, irrespective of OspC or other abundant surface lipoproteins. We conclude that the essential role of OspC is unrelated to resistance to this component of innate immunity. JF - Antimicrobial Agents & Chemotherapy AU - Sarkar, Amit AU - Tilly, Kit AU - Stewart, Philip AU - Bestor, Aaron AU - Battisti, James M AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St., Hamilton, Montana 59840, sarkara@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 4490 EP - 4494 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 53 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - cathelicidins KW - Skin KW - Borrelia burgdorferi KW - Lipoproteins KW - Outer membranes KW - Immunity KW - Infection KW - Antimicrobial peptides KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21475045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Borrelia+burgdorferi+Resistance+to+a+Major+Skin+Antimicrobial+Peptide+Is+Independent+of+Outer+Surface+Lipoprotein+Content&rft.au=Sarkar%2C+Amit%3BTilly%2C+Kit%3BStewart%2C+Philip%3BBestor%2C+Aaron%3BBattisti%2C+James+M%3BRosa%2C+Patricia+A&rft.aulast=Sarkar&rft.aufirst=Amit&rft.date=2009-10-01&rft.volume=53&rft.issue=10&rft.spage=4490&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00558-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Skin; cathelicidins; Outer membranes; Lipoproteins; Immunity; Infection; Antimicrobial peptides; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/AAC.00558-09 ER - TY - JOUR T1 - Prediagnostic Serum Concentrations of Organochlorine Compounds and Risk of Testicular Germ Cell Tumors AN - 21436535; 11866552 AB - Background Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,pa2-dichlorodiphenyldichloroethylene (p,pa2-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs). Objective To further investigate this question, we conducted a nested caseacontrol study of TGCTs within the Norwegian Janus Serum Bank cohort. Methods The study was conducted among individuals with serum collected between 1972 and 1978. TGCT cases diagnosed through 1999 (n = 49; 27a62 years of age at diagnosis) were identified through linkage to the Norwegian Cancer Registry. Controls (n =51) were matched to cases on region, blood draw year, and age at blood draw. Measurements of 11 OC insecticide compounds and 34 polychlorinated biphenyl (PCB) congeners were performed using gas chromatography/high-resolution mass spectrometry. Caseacontrol comparisons of lipid-adjusted analyte concentrations were performed using the Wilcoxon signed-rank test. Odds ratios (ORs) and 95% confidence intervals (CIs) for tertiles of analyte concentration were calculated using conditional logistic regression. Results TGCT cases had elevated concentrations of p,pa2-DDE (tertile 3 vs. tertile 1 OR (OR sub(T3)) 2.2; 95% CI, 0.7a6.5; p sub(Wilcoxon) = 0.07), oxychlordane (OR sub(T3) 3.2; 95% CI, 0.6a16.8; p sub(Wilcoxon) = 0.05), trans-nonachlor (OR sub(T3) 2.6; 95% CI, 0.7a8.9; p sub(Wilcoxon) = 0.07), and total chlordanes (OR sub(T3) 2.0; 95% CI, 0.6a7.2; p sub(Wilcoxon) = 0.048) compared with controls, although no ORs were statistically significant. Seminoma cases had significantly lower concentrations of PCB congeners 44, 49, and 52 and significantly higher concentrations of PCBs 99, 138, 153, 167, 183, and 195. Conclusions Our study provides additional but qualified evidence supporting an association between exposures to p,pa2-DDE and chlordane compounds, and possibly some PCB congeners, and TGCT risk. JF - Environmental Health Perspectives AU - Purdue, Mark P AU - Engel, Lawrence S AU - Langseth, Hilde AU - Needham, Larry L AU - Andersen, Aage AU - Barr, Dana B AU - Blair, Aaron AU - Rothman, Nathaniel AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1514 EP - 1519 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 10 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Environment Abstracts KW - chlordanes KW - organochlorine compounds KW - polychlorinated biphenyls KW - p,pa2-dichloro-diphenyldichloroethylene KW - testicular germ cell tumors KW - Age KW - Insecticides KW - Organochlorine compounds KW - Janus KW - Gas chromatography KW - Chlordane KW - Mass spectrometry KW - tumors KW - Norway KW - PCB compounds KW - Cancer KW - R2 23060:Medical and environmental health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21436535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prediagnostic+Serum+Concentrations+of+Organochlorine+Compounds+and+Risk+of+Testicular+Germ+Cell+Tumors&rft.au=Purdue%2C+Mark+P%3BEngel%2C+Lawrence+S%3BLangseth%2C+Hilde%3BNeedham%2C+Larry+L%3BAndersen%2C+Aage%3BBarr%2C+Dana+B%3BBlair%2C+Aaron%3BRothman%2C+Nathaniel%3BMcGlynn%2C+Katherine+A&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2009-10-01&rft.volume=117&rft.issue=10&rft.spage=1514&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0800359 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Organochlorine compounds; Insecticides; Gas chromatography; Chlordane; Mass spectrometry; tumors; PCB compounds; Cancer; Janus; Norway DO - http://dx.doi.org/10.1289/ehp.0800359 ER - TY - JOUR T1 - Interactions between lipids and voltage sensor paddles detected with tarantula toxins AN - 21430002; 11699280 AB - Voltage-activated ion channels open and close in response to changes in voltage, a property that is essential for generating nerve impulses. Studies on voltage-activated potassium (Kv) channels show that voltage-sensor activation is sensitive to the composition of lipids in the surrounding membrane. Here we explore the interaction of lipids with S1-S4 voltage-sensing domains and find that the conversion of the membrane lipid sphingomyelin to ceramide-1-phosphate alters voltage-sensor activation in an S1-S4 voltage-sensing protein lacking an associated pore domain, and that the S3b-S4 paddle motif determines the effects of lipid modification on Kv channels. Using tarantula toxins that bind to paddle motifs within the membrane, we identify mutations in the paddle motif that weaken toxin binding by disrupting lipid-paddle interactions. Our results suggest that lipids bind to voltage-sensing domains and demonstrate that the pharmacological sensitivities of voltage-activated ion channels are influenced by the surrounding lipid membrane. JF - Nature Structural & Molecular Biology AU - Milescu, Mirela AU - Bosmans, Frank AU - Lee, Seungkyu AU - Alabi, AbdulRasheed A AU - Kim, Jae Il AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1080 EP - 1085 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 10 SN - 1545-9993, 1545-9993 KW - Toxicology Abstracts KW - sphingomyelin KW - Channel pores KW - Potassium KW - Toxins KW - Lipid rafts KW - Nerves KW - Lipid membranes KW - Ion channels KW - Potassium channels (voltage-gated) KW - Araneae KW - Potassium channels KW - Mutation KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21430002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=Interactions+between+lipids+and+voltage+sensor+paddles+detected+with+tarantula+toxins&rft.au=Milescu%2C+Mirela%3BBosmans%2C+Frank%3BLee%2C+Seungkyu%3BAlabi%2C+AbdulRasheed+A%3BKim%2C+Jae+Il%3BSwartz%2C+Kenton+J&rft.aulast=Milescu&rft.aufirst=Mirela&rft.date=2009-10-01&rft.volume=16&rft.issue=10&rft.spage=1080&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb.1679 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Nerves; sphingomyelin; Channel pores; Lipid membranes; Ion channels; Potassium channels (voltage-gated); Potassium; Potassium channels; Mutation; Toxins; Lipid rafts; Araneae DO - http://dx.doi.org/10.1038/nsmb.1679 ER - TY - JOUR T1 - GuaA and GuaB Are Essential for Borrelia burgdorferi Survival in the Tick-Mouse Infection Cycle AN - 21336902; 11917002 AB - Pathogens lacking the enzymatic pathways for de novo purine biosynthesis are required to salvage purines and pyrimidines from the host environment for synthesis of DNA and RNA. Two key enzymes in purine salvage pathways are IMP dehydrogenase (GuaB) and GMP synthase (GuaA), encoded by the guaB and guaA genes, respectively. While these genes are typically found on the chromosome in most bacterial pathogens, the guaAB operon of Borrelia burgdorferi is present on plasmid cp26, which also harbors a number of genes critical for B. burgdorferi viability. Using molecular genetics and an experimental model of the tick-mouse infection cycle, we demonstrate that the enzymatic activities encoded by the guaAB operon are essential for B. burgdorferi mouse infectivity and provide a growth advantage to spirochetes in the tick. These data indicate that the GuaA and GuaB proteins are critical for the survival of B. burgdorferi in the infection cycle and highlight a potential difference in the requirements for purine salvage in the disparate mammalian and tick environments. JF - Journal of Bacteriology AU - Jewett, Mollie W AU - Lawrence, Kevin A AU - Bestor, Aaron AU - Byram, Rebecca AU - Gherardini, Frank AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, jewettm@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 6231 EP - 6241 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 20 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - DNA biosynthesis KW - Molecular modelling KW - Data processing KW - IMP dehydrogenase KW - Borrelia burgdorferi KW - Ixodidae KW - Animal models KW - Survival KW - Pathogens KW - Plasmids KW - Infection KW - purines KW - Spirochetes KW - Chromosomes KW - Infectivity KW - RNA KW - DNA KW - pyrimidines KW - Enzymatic activity KW - Operons KW - GMP synthase KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21336902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=GuaA+and+GuaB+Are+Essential+for+Borrelia+burgdorferi+Survival+in+the+Tick-Mouse+Infection+Cycle&rft.au=Jewett%2C+Mollie+W%3BLawrence%2C+Kevin+A%3BBestor%2C+Aaron%3BByram%2C+Rebecca%3BGherardini%2C+Frank%3BRosa%2C+Patricia+A&rft.aulast=Jewett&rft.aufirst=Mollie&rft.date=2009-10-01&rft.volume=191&rft.issue=20&rft.spage=6231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00450-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 67 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Molecular modelling; DNA biosynthesis; IMP dehydrogenase; Data processing; Animal models; Survival; Pathogens; Infection; Plasmids; purines; Spirochetes; Infectivity; Chromosomes; RNA; DNA; pyrimidines; Enzymatic activity; Operons; GMP synthase; Borrelia burgdorferi; Ixodidae DO - http://dx.doi.org/10.1128/JB.00450-09 ER - TY - JOUR T1 - Evaluation of pulsed high intensity focused ultrasound exposures on metastasis in a murine model AN - 21301819; 11905744 AB - High intensity focused ultrasound (HIFU) may be employed in two ways: continuous exposures for thermal ablation of tissue (>60C), and pulsed-exposures for non-ablative effects, including low temperature hyperthermia (37-45C), and non thermal effects (e.g. acoustic cavitation and radiation forces). Pulsed-HIFU effects may enhance the tissue's permeability for improved delivery of drugs and genes, for example, by opening up gaps between cells in the vasculature and parenchyma. Inducing these effects may improve local targeting of therapeutic agents, however; concerns exist that pulsed exposures could theoretically also facilitate dissemination of tumor cells and exacerbate metastases. In the present study, the influence of pulsed-HIFU exposures on increasing metastatic burden was evaluated in a murine model with metastatic breast cancer. A preliminary study was carried out to validate the model and determine optimal timing for treatment and growth of lung metastases. Next, the effect of pulsed-HIFU on the metastatic burden was evaluated using quantitative image processing of whole-lung histological sections. Compared to untreated controls (2/15), a greater number of mice treated with pulsed-HIFU were found to have lungs 'overgrown' with metastases (7/15), where individual metastases grew together such that they could not accurately be counted. Furthermore, area fraction of lung metastases (area of metastases/area of lungs) was ~30% greater in mice treated with pulsed-HIFU; however, these differences were not statistically significant. The present study details the development of an animal model for investigating the influence of interventional techniques or exposures (such as pulsed HIFU) on metastatic burden. JF - Clinical & Experimental Metastasis AU - Hancock, Hilary AU - Dreher, Matthew R AU - Crawford, Nigel AU - Pollock, Claire B AU - Shih, Jennifer AU - Wood, Bradford J AU - Hunter, Kent AU - Frenkel, Victor AD - Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA, vfrenkel@cc.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 729 EP - 738 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 26 IS - 7 SN - 0262-0898, 0262-0898 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Parenchyma KW - Drug delivery KW - Hyperthermia KW - Acoustics KW - Statistical analysis KW - Animal models KW - Image processing KW - Tumor cells KW - Metastases KW - Permeability KW - Cavitation KW - Radiation KW - Lung KW - Breast cancer KW - Ultrasound KW - W 30910:Imaging KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21301819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+%26+Experimental+Metastasis&rft.atitle=Evaluation+of+pulsed+high+intensity+focused+ultrasound+exposures+on+metastasis+in+a+murine+model&rft.au=Hancock%2C+Hilary%3BDreher%2C+Matthew+R%3BCrawford%2C+Nigel%3BPollock%2C+Claire+B%3BShih%2C+Jennifer%3BWood%2C+Bradford+J%3BHunter%2C+Kent%3BFrenkel%2C+Victor&rft.aulast=Hancock&rft.aufirst=Hilary&rft.date=2009-10-01&rft.volume=26&rft.issue=7&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Clinical+%26+Experimental+Metastasis&rft.issn=02620898&rft_id=info:doi/10.1007%2Fs10585-009-9272-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Parenchyma; Temperature effects; Drug delivery; Hyperthermia; Acoustics; Animal models; Statistical analysis; Image processing; Tumor cells; Metastases; Permeability; Radiation; Cavitation; Lung; Breast cancer; Ultrasound DO - http://dx.doi.org/10.1007/s10585-009-9272-9 ER - TY - JOUR T1 - Gastrointestinal microflora, food components and colon cancer prevention AN - 21254063; 11043855 AB - Evidence that the intestinal microbiota is intrinsically linked with overall health, including cancer risk, is emerging. Moreover, its composition is not fixed but can be influenced by several dietary components. Dietary modifiers, including the consumption of live bacteria (probiotics) and indigestible or limited digestible food constituents such as oligosaccharides (prebiotics) and polyphenols or both (synbiotics), are recognized modifiers of the numbers and types of microbes and have been reported to reduce colon cancer risk experimentally. Microorganisms also have the ability to generate bioactive compounds from food components. Examples include equol from isoflavones, enterodiol and enterolactone from lignans and urolithins from ellagic acid, which have also been demonstrated to retard experimentally induced cancers. The gastrointestinal microbiota can also influence both sides of the energy balance equation, namely, as a factor influencing energy utilization from the diet and as a factor that influences host genes that regulate energy expenditure and storage. Because of the link between obesity and cancer incidence and mortality, this complex complexion deserves greater attention. Overall, a dynamic interrelationship exists between the intestinal microbiota and colon cancer risk, which can be modified by dietary components and eating behaviors. JF - Journal of Nutritional Biochemistry AU - Davis, Cindy D AU - Milner, John A AD - Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA, davisci@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 743 EP - 752 PB - Elsevier Science, 360 Park Ave. South New York NY 10010-1710 USA, [mailto:usinfo-f@elsevier.com] VL - 20 IS - 10 SN - 0955-2863, 0955-2863 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Prebiotics KW - Probiotics KW - Microbiota KW - Colon cancer KW - Diets KW - Obesity KW - Mortality KW - Mathematical models KW - oligosaccharides KW - Polyphenols KW - Food KW - Energy utilization KW - probiotics KW - Isoflavones KW - Intestinal microflora KW - Energy expenditure KW - Energy balance KW - Microorganisms KW - Microflora KW - ellagic acid KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21254063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutritional+Biochemistry&rft.atitle=Gastrointestinal+microflora%2C+food+components+and+colon+cancer+prevention&rft.au=Davis%2C+Cindy+D%3BMilner%2C+John+A&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2009-10-01&rft.volume=20&rft.issue=10&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutritional+Biochemistry&rft.issn=09552863&rft_id=info:doi/10.1016%2Fj.jnutbio.2009.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; Mortality; Obesity; oligosaccharides; Mathematical models; Polyphenols; Food; Energy utilization; probiotics; Colon cancer; Isoflavones; Intestinal microflora; Energy expenditure; Energy balance; Microflora; Microorganisms; ellagic acid DO - http://dx.doi.org/10.1016/j.jnutbio.2009.06.001 ER - TY - JOUR T1 - An update on community-associated MRSA virulence AN - 21252732; 11091391 AB - Staphylococcus aureus is a major health problem worldwide and the leading cause of bacterial infections in the United States. Historically, the success of S. aureus as a human pathogen has been facilitated by a strong propensity to develop antibiotic resistance and multidrug resistant strains are endemic in hospitals. However, one of the most striking developments in recent bacterial infectious disease history was the rapid emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). First reported in the 1990s, CA-MRSA has since emerged worldwide and is epidemic in the United States. The pathogen is characterized by its ability to spread rapidly and cause infections in otherwise healthy individuals. This review focuses on current progress toward understanding the enhanced virulence properties of CA-MRSA, with an emphasis on Panton-Valentine leukocidin, a-hemolysin, and the recently discovered a- type phenol-soluble modulins. JF - Current Opinion in Pharmacology AU - Kobayashi, Scott D AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, fdeleo@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 545 EP - 551 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 9 IS - 5 SN - 1471-4892, 1471-4892 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Epidemics KW - leukocidin KW - Drug resistance KW - Pathogens KW - Infection KW - Virulence KW - Infectious diseases KW - Reviews KW - Multidrug resistance KW - Staphylococcus aureus KW - Antibiotic resistance KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21252732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Pharmacology&rft.atitle=An+update+on+community-associated+MRSA+virulence&rft.au=Kobayashi%2C+Scott+D%3BDeLeo%2C+Frank+R&rft.aulast=Kobayashi&rft.aufirst=Scott&rft.date=2009-10-01&rft.volume=9&rft.issue=5&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Pharmacology&rft.issn=14714892&rft_id=info:doi/10.1016%2Fj.coph.2009.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Virulence; Epidemics; Infectious diseases; leukocidin; Reviews; Drug resistance; Multidrug resistance; Pathogens; Infection; Antibiotic resistance; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.coph.2009.07.009 ER - TY - JOUR T1 - Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum AN - 21194259; 11098345 AB - Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were active in inhibiting parasite growth; 607 differential chemical phenotypes, defined as pairwise IC sub(50) differences of fivefold or more between parasite lines, were cataloged. We mapped major determinants for three differential chemical phenotypes between the parents of a genetic cross, and we identified target genes by fine mapping and testing the responses of parasites in which candidate genes were genetically replaced with mutant alleles. Differential sensitivity to dihydroergotamine methanesulfonate (1), a serotonin receptor antagonist, was mapped to a gene encoding the homolog of human P-glycoprotein (PfPgh-1). This study identifies new leads for antimalarial drugs and demonstrates the utility of a high-throughput chemical genomic strategy for studying malaria traits. JF - Nature Chemical Biology AU - Yuan, Jing AU - Johnson, Ronald L AU - Huang, Ruili AU - Wichterman, Jennifer AU - Jiang, Hongying AU - Hayton, Karen AU - Fidock, David A AU - Wellems, Thomas E AU - Inglese, James AU - Austin, Christopher P AU - Su, Xin-zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 765 EP - 771 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 5 IS - 10 SN - 1552-4450, 1552-4450 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Molecular modelling KW - Parasites KW - Human diseases KW - Allelles KW - Receptors KW - Malaria KW - Plasmodium falciparum KW - Phenotypes KW - Public health KW - P-Glycoprotein KW - Growth KW - Serotonin receptors KW - genomics KW - Drugs KW - Gene mapping KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21194259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Chemical+Biology&rft.atitle=Genetic+mapping+of+targets+mediating+differential+chemical+phenotypes+in+Plasmodium+falciparum&rft.au=Yuan%2C+Jing%3BJohnson%2C+Ronald+L%3BHuang%2C+Ruili%3BWichterman%2C+Jennifer%3BJiang%2C+Hongying%3BHayton%2C+Karen%3BFidock%2C+David+A%3BWellems%2C+Thomas+E%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BSu%2C+Xin-zhuan&rft.aulast=Yuan&rft.aufirst=Jing&rft.date=2009-10-01&rft.volume=5&rft.issue=10&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Nature+Chemical+Biology&rft.issn=15524450&rft_id=info:doi/10.1038%2Fnchembio.215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Growth; Allelles; Receptors; Malaria; Drugs; Phenotypes; Public health; Molecular modelling; P-Glycoprotein; Serotonin receptors; genomics; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1038/nchembio.215 ER - TY - JOUR T1 - Urinary MDMA, MDA, HMMA, and HMA Excretion Following Controlled MDMA Administration to Humans AN - 21187710; 11278641 AB - 3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is excreted as unchanged drug, 3,4-methylenedioxyamphetamine (MDA), and free and glucuronidated/sulfated 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA) metabolites. The aim of this paper is to describe the pattern and timeframe of excretion of MDMA and its metabolites in urine. Placebo, 1.0 mg/kg, and 1.6 mg/kg oral MDMA doses were administered double-blind to healthy adult MDMA users on a monitored research unit. All urine was collected, aliquots were hydrolyzed, and analytes quantified by gas chromatography-mass spectrometry. Median Cmax, Tmax, ratios, first and last detection times, and detection rates were determined. Sixteen participants provided 916 urine specimens. After 1.6 mg/kg, median Cmax were 21,470 (MDMA), 2229 (MDA), 20,793 (HMMA), and 876 ng/mL (HMA) at median Tmax of 13.9, 23.0, 9.2 and 23.3 h. In the first 24 h, 30.2-34.3% total urinary excretion occurred. HMMA last detection exceeded MDMA's by more than 33 h after both doses. Identification of HMMA as well as MDMA increased the ability to identify positive specimens but required hydrolysis. These MDMA, MDA, HMMA, and HMA pharmacokinetic data may be useful for interpreting workplace, drug treatment, criminal justice, and military urine drug tests. Measurement of urinary HMMA provides the longest detection of MDMA exposure yet is not included in routine monitoring procedures. JF - Journal of Analytical Toxicology AU - Abraham, Tsadik T AU - Barnes, Allan J AU - Lowe, Ross H AU - Kolbrich Spargo, Erin A AU - Milman, Garry AU - Pirnay, Stephane O AU - Gorelick, David A AU - Goodwin, Robert S AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224 Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 439 EP - 446 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 USA VL - 33 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Data processing KW - Urine KW - Gas chromatography KW - Excretion KW - Metabolites KW - Drug abuse KW - MDMA KW - Hydrolysis KW - Mass spectroscopy KW - Pharmacokinetics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21187710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Urinary+MDMA%2C+MDA%2C+HMMA%2C+and+HMA+Excretion+Following+Controlled+MDMA+Administration+to+Humans&rft.au=Abraham%2C+Tsadik+T%3BBarnes%2C+Allan+J%3BLowe%2C+Ross+H%3BKolbrich+Spargo%2C+Erin+A%3BMilman%2C+Garry%3BPirnay%2C+Stephane+O%3BGorelick%2C+David+A%3BGoodwin%2C+Robert+S%3BHuestis%2C+Marilyn+A&rft.aulast=Abraham&rft.aufirst=Tsadik&rft.date=2009-10-01&rft.volume=33&rft.issue=8&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Gas chromatography; Urine; Metabolites; Excretion; Drug abuse; Hydrolysis; MDMA; Pharmacokinetics; Mass spectroscopy ER - TY - JOUR T1 - On the Origin of Cells and Viruses AN - 21184771; 11213083 AB - It is proposed that the precellular stage of biological evolution unraveled within networks of inorganic compartments that harbored a diverse mix of virus-like genetic elements. This stage of evolution might makes up the Last Universal Cellular Ancestor (LUCA) that more appropriately could be denoted Last Universal Cellular Ancestral State (LUCAS). Such a scenario recapitulates the ideas of J. B. S. Haldane sketched in his classic 1928 essay. However, unlike in Haldane's day, considerable support for this scenario exits today: lack of homology between core DNA replication system components in archaea and bacteria, distinct membrane chemistries and enzymes of lipid biosynthesis in archaea and bacteria, spread of several viral hallmark genes among diverse groups of viruses, and the extant archaeal and bacterial chromosomes appear to be shaped by accretion of diverse, smaller replicons. Under the viral model of precellular evolution, the key components of cells originated as components of virus-like entities. The two surviving types of cellular life forms, archaea and bacteria, might have emerged from the LUCAS independently, along with, probably, numerous forms now extinct. JF - Annals of the New York Academy of Sciences AU - Koonin, Eugene V AD - aNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 47 EP - 64 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 1178 IS - 1 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - comparative genomics KW - evolution of cells KW - evolution of viruses KW - origin of membranes KW - viral hallmark genes KW - DNA biosynthesis KW - Chromosomes KW - Archaea KW - Homology KW - Replication KW - Lipids KW - Enzymes KW - Evolution KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=On+the+Origin+of+Cells+and+Viruses&rft.au=Koonin%2C+Eugene+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2009-10-01&rft.volume=1178&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.04992.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Chromosomes; Homology; Replication; Lipids; Enzymes; Evolution; Archaea DO - http://dx.doi.org/10.1111/j.1749-6632.2009.04992.x ER - TY - JOUR T1 - Summary of the 2008 National Institute of Allergy and Infectious Diseases-US Food and Drug Administration Workshop on Food Allergy Clinical Trial Design AN - 21165096; 11352113 AB - This article summarizes the proceedings of a 2008 Workshop on Food Allergy Clinical Trials Design co-organized by the National Institute of Allergy and Infectious Diseases and the US Food and Drug Administration. The use of food allergens both as therapy and for oral food challenges is associated with a risk of anaphylaxis. Investigators are strongly encouraged to address regulatory considerations by discussing proposed studies with the US Food and Drug Administration. Food allergen administration through the oral or sublingual routes might be less risky than through the subcutaneous route, but this hypothesis has not been proved, and subjects with food allergy might still be at high risk of allergic reactions to such allergen administration. Two distinct mechanisms might lead to beneficial clinical outcomes: desensitization (reversible when food allergen therapy is stopped) and tolerance (persistent benefit even after allergen therapy is stopped). There are important clinical distinctions between desensitization and tolerance. The efficacy of a therapy for food allergy can be evaluated by assessing changes in the dose response to double-blind, placebo-controlled oral food challenges before and after therapy and also by assessing changes in the number of allergic episodes during a longitudinal natural history/exposure study; both approaches have strengths and limitations. JF - Journal of Allergy and Clinical Immunology AU - Plaut, Marshall AU - Sawyer, Richard T AU - Fenton, Matthew J AD - Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, mplaut@niaid.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 671 EP - 678.e1 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA VL - 124 IS - 4 SN - 0091-6749, 0091-6749 KW - Toxicology Abstracts; Immunology Abstracts KW - Allergens KW - Anaphylaxis KW - Clinical trials KW - Conferences KW - Drug development KW - Food hypersensitivity KW - Hypersensitivity KW - Immunological tolerance KW - Infectious diseases KW - Risk factors KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21165096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Summary+of+the+2008+National+Institute+of+Allergy+and+Infectious+Diseases-US+Food+and+Drug+Administration+Workshop+on+Food+Allergy+Clinical+Trial+Design&rft.au=Plaut%2C+Marshall%3BSawyer%2C+Richard+T%3BFenton%2C+Matthew+J&rft.aulast=Plaut&rft.aufirst=Marshall&rft.date=2009-10-01&rft.volume=124&rft.issue=4&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.05.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Food hypersensitivity; Infectious diseases; Conferences; Anaphylaxis; Risk factors; Allergens; Drug development; Immunological tolerance; Clinical trials DO - http://dx.doi.org/10.1016/j.jaci.2009.05.027 ER - TY - JOUR T1 - ERK1/2 Activation Induced by Inflammatory Cytokines Compromises Effective Host Tissue Integration of Engineered Cartilage AN - 21135125; 11147760 AB - Objective: Proinflammatory cytokines are known to provoke degradative signaling cascades that promote extracellular matrix disintegration in articular cartilage. Because integration of the repair tissue into the surrounding native cartilage to produce a mechanically stable interface has a profound impact on the viability and functionality of the restored joint surface, this study examined the effects of proinflammatory cytokines on the properties of tissue-engineered cartilage in the context of integration. Methods: Using an established in vitro cartilage defect model, we examined the integration of chondrocyte-laden agarose constructs into native articular cartilage and the biochemical and biomechanical alterations of these implants upon treatment with inter-leukin 1- beta (IL1- beta ) and tumor necrosis factor- alpha (TNF- alpha ). Additionally, we probed extracellular regulated kinase (ERK) signaling involvement in response to proinflammatory cytokines. Results: The time-dependent accumulation of extracellular matrix and concomitant increase in Young's modulus observed in the absence of cytokines was significantly decreased upon IL1- beta and TNF- alpha treatment. Push-out test showed the highest interface strength in hybrid cultures maintained without cytokines, which was significantly lowered with IL1- beta and TNF- alpha treatment. Histological characteristics of the interface region are consistent with the biochemical findings. Treatment with an inhibitor of ERK pathway antagonized the deleterious effects caused by both cytokines. Conclusion: This study is the first to show the functional catastrophic effects of IL1- beta and TNF- alpha on the biochemical, structural, and integrative properties of tissue-engineered cartilage and their significant counteraction by the blockade of ERK signaling pathway. With the discovery of new potential chemical entities, ERK inhibitor may emerge as a new therapeutic approach for functional integration and mechanical integrity of an engineered cartilage to the host tissue and, therefore, enhance long-term viability and functionality of the restored joint surface. JF - Tissue Engineering, Part A: Tissue Engineering AU - Djouad, F AU - Rackwitz, L AU - Song, Y AU - Janjanin, S AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department cf Health and Human Services, 50 South Dr., Room 1140, MSC 8022, Bethesda, MD 20892-8022, USA, tuanr@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 2825 EP - 2835 VL - 15 IS - 10 SN - 1937-3341, 1937-3341 KW - Immunology Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Interleukin 1 KW - Joint diseases KW - Models KW - Integration KW - Extracellular signal-regulated kinase KW - Hybrids KW - Cytokines KW - Cartilage (articular) KW - Mechanical properties KW - Tissue engineering KW - Tumor necrosis factor-a KW - Joints KW - Inflammation KW - Extracellular matrix KW - Tumor necrosis factor-^a KW - Signal transduction KW - T 2030:Cartilage and Cartilage Diseases KW - F 06960:Molecular Immunology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21135125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=ERK1%2F2+Activation+Induced+by+Inflammatory+Cytokines+Compromises+Effective+Host+Tissue+Integration+of+Engineered+Cartilage&rft.au=Djouad%2C+F%3BRackwitz%2C+L%3BSong%2C+Y%3BJanjanin%2C+S%3BTuan%2C+R+S&rft.aulast=Djouad&rft.aufirst=F&rft.date=2009-10-01&rft.volume=15&rft.issue=10&rft.spage=2825&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2008.0663 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cartilage (articular); Tumor necrosis factor-a; Extracellular signal-regulated kinase; Inflammation; Interleukin 1; Tissue engineering; Integration; Signal transduction; Cytokines; Extracellular matrix; Joints; Joint diseases; Models; Mechanical properties; Hybrids; Tumor necrosis factor-^a DO - http://dx.doi.org/10.1089/ten.tea.2008.0663 ER - TY - JOUR T1 - D-Cycloserine Facilitation of Fear Extinction and Exposure-Based Therapy Might Rely on Lower-Level, Automatic Mechanisms AN - 21126555; 11071886 AB - Exposure-based therapy, a leading technique in the treatment of a range of anxiety disorders, is facilitated by D-cycloserine (DCS), a partial N-methyl-D-aspartate receptor agonist. This review discusses the potential mechanisms involved in this facilitation and its implications for developing theories of fear conditioning in humans. Basic research in rodents suggests that DCS acts by speeding up extinction. However, several laboratory-based investigations found that DCS had no effect on extinction in humans. This report proposes that these observations can be accounted for by a dual-model theory of fear conditioning in humans that engages two complementary defensive systems: a reflexive lower-order system independent of conscious awareness and a higher-order cognitive system associated with conscious awareness of danger and expectation. The DCS studies in animals seem to have explored lower-order conditioning mechanisms, whereas human studies have explored higher-order cognitive processes. These observations suggest that DCS might act preferentially on lower- rather than higher-order learning. This report presents evidence suggesting that, in humans, DCS might similarly affect lower-order learning during exposure-based therapy and, consequently, might be less effective during cognitive therapy (e.g., cognitive restructuring). Finally, it is recommended that extinction studies using DCS in humans be conducted with fear-relevant stimuli (e.g., snakes), short conditional stimulus-unconditioned stimulus intervals and intense unconditioned stimulus to promote lower-order conditioning processes. JF - Biological Psychiatry AU - Grillon, Christian AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA, Christian.grillon@nih.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 636 EP - 641 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 66 IS - 7 SN - 0006-3223, 0006-3223 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Cycloserine KW - Learning KW - N-Methyl-D-aspartic acid receptors KW - Extinction KW - Anxiety KW - Cognitive ability KW - Reviews KW - UCS KW - Fear conditioning KW - Glutamic acid receptors KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21126555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=D-Cycloserine+Facilitation+of+Fear+Extinction+and+Exposure-Based+Therapy+Might+Rely+on+Lower-Level%2C+Automatic+Mechanisms&rft.au=Grillon%2C+Christian&rft.aulast=Grillon&rft.aufirst=Christian&rft.date=2009-10-01&rft.volume=66&rft.issue=7&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2009.04.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Cycloserine; N-Methyl-D-aspartic acid receptors; Learning; Anxiety; Extinction; Cognitive ability; Reviews; UCS; Fear conditioning; Glutamic acid receptors DO - http://dx.doi.org/10.1016/j.biopsych.2009.04.017 ER - TY - JOUR T1 - Co-morbidities in people living with epilepsy: Hospital based case-control study from a resource-poor setting AN - 21118746; 11090457 AB - Purpose - Evaluating co-morbidity in people living with epilepsy (PWE) is essential and its modification might improve their quality of life. We analyzed the various co-morbidities in PWE in comparison with the normal healthy controls. Method - This prospective study was conducted from July 2006 to December 2007. PWE attending neurology outpatient services (n = 250) with age ranging from 16 to 60 years (29.66 +/- 11.31 years; M:F 116:134) were recruited after obtaining informed consent. Healthy matched controls (n = 250; 30.35 +/- 11.05 years; M:F 114:136) were also recruited. Results - The seizure types were: generalized (62.4%), complex-partial (21.6%), simple-partial (8.8%), and unclassified (7.2%). Sixty-nine percent were on monotherapy, and rest required polytherapy, with 90.8% on adequate dosages of anti-convulsants. About 83.2% were compliant and 70.4% had satisfactory control of seizures. At least 1 co-morbid condition was noted in 152 (60.8%) cases and among them, 62 (24.8%) had >=2 co-morbidities. Control population was also evaluated for the presence of same co-morbidities and compared with cases. The various significant co-morbidities included: migraine (cases: 25.6% vs. controls: 15.2%; p = 0.02), anxiety (cases: 2.4% vs. controls: 0%; p = 0.04), depression (case: 5.2% vs. controls: 0.4%; p = 0.0009), sleep disturbances (case: 6.8% vs. controls: 0.4%; p = 0.0002), neurocysticercosis (cases: 15.6% vs. controls: 0%; p = < 0.001), pulmonary tuberculosis (cases: 3.6% vs. controls: 0%; p = 0.002) and extra-pulmonary tuberculosis (cases: 2.8% vs. controls: 0.4%; p = 0.03). Less common co-morbidities were hypertension, diabetes, osteoarthritis, asthma, hypothyroidism, and acid-peptic disease. Conclusion - In people living with epilepsy attending neurology OPD services, co-morbid illnesses were commonly observed compared to healthy controls. JF - Epilepsy Research AU - Babu, CShyam AU - Satishchandra, P AU - Sinha, S AU - Subbakrishna, D K AD - Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560 029, Karnataka, India, sanjib_sinha2004@yahoo.co.in Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 146 EP - 152 PB - Elsevier BV VL - 86 IS - 2-3 SN - 0920-1211, 0920-1211 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Case-control KW - Co-morbidity KW - Epilepsy KW - Migraine KW - Age KW - Depression KW - Anxiety KW - Mycobacterium KW - Osteoarthritis KW - Seizures KW - Asthma KW - Diabetes mellitus KW - Lung KW - Sleep KW - Headache KW - Hypothyroidism KW - Cysticercosis KW - Tuberculosis KW - Taenia KW - Hospitals KW - Quality of life KW - Hypertension KW - J 02400:Human Diseases KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21118746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+Research&rft.atitle=Co-morbidities+in+people+living+with+epilepsy%3A+Hospital+based+case-control+study+from+a+resource-poor+setting&rft.au=Babu%2C+CShyam%3BSatishchandra%2C+P%3BSinha%2C+S%3BSubbakrishna%2C+D+K&rft.aulast=Babu&rft.aufirst=CShyam&rft.date=2009-10-01&rft.volume=86&rft.issue=2-3&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Epilepsy+Research&rft.issn=09201211&rft_id=info:doi/10.1016%2Fj.eplepsyres.2009.05.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Depression; Anxiety; Osteoarthritis; Seizures; Asthma; Diabetes mellitus; Epilepsy; Lung; Migraine; Sleep; Headache; Cysticercosis; Hypothyroidism; Tuberculosis; Hypertension; Quality of life; Hospitals; Mycobacterium; Taenia DO - http://dx.doi.org/10.1016/j.eplepsyres.2009.05.015 ER - TY - JOUR T1 - Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 T study AN - 21086694; 11073841 AB - Signal fluctuations in functional magnetic resonance imaging (fMRI) can result from a number of sources that may have a neuronal, physiologic or instrumental origin. To determine the relative contribution of these sources, we recorded physiological (respiration and cardiac) signals simultaneously with fMRI in human volunteers at rest with their eyes closed. State-of-the-art technology was used including high magnetic field (7 T), a multichannel detector array and high-resolution (3 mm super(3)) echo-planar imaging. We investigated the relative contribution of thermal noise and other sources of variance to the observed fMRI signal fluctuations both in the visual cortex and in the whole brain gray matter. The following sources of variance were evaluated separately: low-frequency drifts due to scanner instability, effects correlated with respiratory and cardiac cycles, effects due to variability in the respiratory flow rate and cardiac rate, and other sources, tentatively attributed to spontaneous neuronal activity. We found that low-frequency drifts are the most significant source of fMRI signal fluctuations (3.0% signal change in the visual cortex, TE=32 ms), followed by spontaneous neuronal activity (2.9%), thermal noise (2.1%), effects due to variability in physiological rates (respiration 0.9%, heartbeat 0.9%), and correlated with physiological cycles (0.6%). We suggest the selection and use of four lagged physiological noise regressors as an effective model to explain the variance related to fluctuations in the rates of respiration volume change and cardiac pulsation. Our results also indicate that, compared to the whole brain gray matter, the visual cortex has higher sensitivity to changes in both the rate of respiration and the spontaneous resting-state activity. Under the conditions of this study, spontaneous neuronal activity is one of the major contributors to the measured fMRI signal fluctuations, increasing almost twofold relative to earlier experiments under similar conditions at 3 T. JF - Magnetic Resonance Imaging AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - Van Gelderen, Peter AU - Horovitz, Silvina G AU - De Zwart, Jacco A AU - Shmueli, Karin AU - Duyn, Jeff H AD - Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD 20892-1065, USA, bianciardim@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1019 EP - 1029 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 27 IS - 8 SN - 0730-725X, 0730-725X KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Heart KW - Brain mapping KW - Neuroimaging KW - Respiration KW - Functional magnetic resonance imaging KW - Heart rate KW - Magnetic fields KW - Drift KW - Cortex (visual) KW - Substantia grisea KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21086694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Sources+of+functional+magnetic+resonance+imaging+signal+fluctuations+in+the+human+brain+at+rest%3A+a+7+T+study&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3BVan+Gelderen%2C+Peter%3BHorovitz%2C+Silvina+G%3BDe+Zwart%2C+Jacco+A%3BShmueli%2C+Karin%3BDuyn%2C+Jeff+H&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2009-10-01&rft.volume=27&rft.issue=8&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2009.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Respiration; Cortex (visual); Brain mapping; Heart; Substantia grisea; Drift; Heart rate; Magnetic fields; Neuroimaging DO - http://dx.doi.org/10.1016/j.mri.2009.02.004 ER - TY - JOUR T1 - Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders AN - 21081885; 11089552 AB - A rising tide of obesity and type 2 diabetes has resulted from the development of technologies that have made inexpensive high calorie foods readily available and exercise unnecessary for many people. Obesity and the metabolic syndrome (insulin resistance, visceral adiposity and dyslipidemia) wreak havoc on cells throughout the body thereby promoting cardiovascular and kidney disease, and degenerative diseases of the brain and body. Obesity and insulin resistance promote disease by increasing oxidative damage to proteins, lipids and DNA as the result of a combination of increased free radical production and an impaired ability of cells to detoxify the radicals and repair damaged molecules. By covalently modifying membrane-associated proteins, the membrane lipid peroxidation product 4-hydroxynonenal (HNE) may play particularly sinister roles in the metabolic syndrome and associated disease processes. HNE can damage pancreatic beta cells and can impair the ability of muscle and liver cells to respond to insulin. HNE may promote atherosclerosis by modifying lipoproteins and can cause cardiac cell damage by impairing metabolic enzymes. An adverse role for HNE in the brain in obesity and the metabolic syndrome is suggested by studies showing that HNE levels are increased in brain cells with aging and Alzheimers disease. HNE can cause the dysfunction and degeneration of neurons by modifying membrane-associated glucose and glutamate transporters, ion-motive ATPases, enzymes involved in amyloid metabolism, and cytoskeletal proteins. Exercise and dietary energy restriction reduce HNE production and may also increase cellular systems for HNE detoxification including glutathione and oxidoreductases. The recent development of low molecular weight molecules that scavenge HNE suggests that HNE can be targeted in the design of drugs for the treatment of obesity, the metabolic syndrome, and associated disorders. JF - Experimental Gerontology AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, BRC 5C214, 251 Bayview Boulevard, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 625 EP - 633 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 44 IS - 10 SN - 0531-5565, 0531-5565 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Exercise physiology KW - Calories KW - Glutathione KW - Hepatocytes KW - Pancreas KW - Lipids KW - Aging KW - Alzheimer's disease KW - Food availability KW - Hormones KW - Insulin KW - 4-Hydroxynonenal KW - Geriatrics KW - Diseases KW - Degenerative diseases KW - Vascular system KW - Heart KW - Obesity KW - Adenosinetriphosphatase KW - Free radicals KW - Metabolic disorders KW - Muscles KW - Brain KW - Enzymes KW - Tides KW - Lipid peroxidation KW - Physical training KW - Diabetes mellitus KW - Neurodegenerative diseases KW - Neurons KW - Dyslipidemia KW - Lipoproteins KW - oxidoreductase KW - Proteins KW - Metabolism KW - Amyloid KW - N3 11024:Neuroimmunology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21081885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Gerontology&rft.atitle=Roles+of+the+lipid+peroxidation+product+4-hydroxynonenal+in+obesity%2C+the+metabolic+syndrome%2C+and+associated+vascular+and+neurodegenerative+disorders&rft.au=Mattson%2C+Mark+P&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2009-10-01&rft.volume=44&rft.issue=10&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Experimental+Gerontology&rft.issn=05315565&rft_id=info:doi/10.1016%2Fj.exger.2009.07.003 LA - English DB - Physical Education Index N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Diseases; Lipids; Hormones; Brain; Proteins; Enzymes; Degenerative diseases; Exercise physiology; Metabolic disorders; Insulin; Lipid peroxidation; 4-Hydroxynonenal; Physical training; Neurodegenerative diseases; Metabolism; Vascular system; Muscles; Alzheimer's disease; Heart; Adenosinetriphosphatase; Neurons; Lipoproteins; oxidoreductase; Free radicals; Dyslipidemia; Hepatocytes; Calories; Glutathione; Aging; Food availability; Tides; Geriatrics; Pancreas; Diabetes mellitus; Amyloid DO - http://dx.doi.org/10.1016/j.exger.2009.07.003 ER - TY - JOUR T1 - Investigations into Pulsed High-Intensity Focused Ultrasound-Enhanced Delivery: Preliminary Evidence for a Novel Mechanism AN - 21081247; 11090609 AB - Pulsed high-intensity focused ultrasound (HIFU) exposures without ultrasound contrast agents have been used for noninvasively enhancing the delivery of various agents to improve their therapeutic efficacy in a variety of tissue models in a nondestructive manner. Despite the versatility of these exposures, little is known about the mechanisms by which their effects are produced. In this study, pulsed-HIFU exposures were given in the calf muscle of mice, followed by the administration of a variety of fluorophores, both soluble and particulate, by local or systemic injection. In vivo imaging (whole animal and microscopic) was used to quantify observations of increased extravasation and interstitial transport of the fluorophores as a result of the exposures. Histological analysis indicated that the exposures caused some structural alterations such as enlarged gaps between muscle fiber bundles. These effects were consistent with increasing the permeability of the tissues; however, they were found to be transient and reversed themselves gradually within 72 h. Simulations of radiation force-induced displacements and the resulting local shear strain they produced were carried out to potentially explain the manner by which these effects occurred. A better understanding of the mechanisms involved with pulsed HIFU exposures for noninvasively enhancing delivery will facilitate the process for optimizing their use. JF - Ultrasound in Medicine & Biology AU - Hancock, Hilary A AU - Smith, Lauren H AU - Cuesta, Julian AU - Durrani, Amir K AU - Angstadt, Mary AU - Palmeri, Mark L AU - Kimmel, Eitan AU - Frenkel, Victor Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1722 EP - 1736 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 35 IS - 10 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Permeability KW - Radiation KW - Contrast media KW - Muscles KW - fluorophores KW - Extravasation KW - imaging KW - Ultrasound KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21081247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Investigations+into+Pulsed+High-Intensity+Focused+Ultrasound-Enhanced+Delivery%3A+Preliminary+Evidence+for+a+Novel+Mechanism&rft.au=Hancock%2C+Hilary+A%3BSmith%2C+Lauren+H%3BCuesta%2C+Julian%3BDurrani%2C+Amir+K%3BAngstadt%2C+Mary%3BPalmeri%2C+Mark+L%3BKimmel%2C+Eitan%3BFrenkel%2C+Victor&rft.aulast=Hancock&rft.aufirst=Hilary&rft.date=2009-10-01&rft.volume=35&rft.issue=10&rft.spage=1722&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2009.04.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ultrasound; Muscles; fluorophores; imaging; Radiation; Models; Contrast media; Extravasation; Permeability DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2009.04.020 ER - TY - JOUR T1 - RADRUE METHOD FOR RECONSTRUCTION OF EXTERNAL PHOTON DOSES FOR CHERNOBYL LIQUIDATORS IN EPIDEMIOLOGICAL STUDIES AN - 20970030; 11060834 AB - Between 1986 and 1990, several hundred thousand workers, called "liquidators" or "clean-up workers," took part in decontamination and recovery activities within the 30-km zone around the Chernobyl nuclear power plant in Ukraine, where a major accident occurred in April 1986. The Chernobyl liquidators were mainly exposed to external ionizing radiation levels that depended primarily on their work locations and the time after the accident when the work was performed. Because individual doses were often monitored inadequately or were not monitored at all for the majority of liquidators, a new method of photon (i.e., gamma and x rays) dose assessment, called "RADRUE" (Realistic Analytical Dose Reconstruction with Uncertainty Estimation), was developed to obtain unbiased and reasonably accurate estimates for use in three epidemiologic studies of hematological malignancies and thyroid cancer among liquidators. The RADRUE program implements a time-and-motion dose-reconstruction method that is flexible and conceptually easy to understand. It includes a large exposure rate database and interpolation and extrapolation techniques to calculate exposure rates at places where liquidators lived and worked within 670 km of the destroyed reactor. The RADRUE technique relies on data collected from subjects' interviews conducted by trained interviewers, and on expert dosimetrists to interpret the information and provide supplementary information, when necessary, based upon their own Chernobyl experience. The RADRUE technique was used to estimate doses from external irradiation, as well as uncertainties, to the bone marrow for 929 subjects and to the thyroid gland for 530 subjects enrolled in epidemiologic studies. Individual bone marrow dose estimates were found to range from less than one kGy to 3,300 mGy, with an arithmetic mean of 71 mGy. Individual thyroid dose estimates were lower and ranged from 20 kGy to 507 mGy, with an arithmetic mean of 29 mGy. The uncertainties, expressed in terms of geometric standard deviations, ranged from 1.1 to 5.8, with an arithmetic mean of 1.9. JF - Health Physics AU - Kryuchkov, V AU - Chumak, V AU - Maceika, E AU - Anspaugh, L R AU - Cardis, E AU - Bakhanova, E AU - Golovanov, I AU - Drozdovitch, V AU - Luckyanov, N AU - Kesminiene, A AU - Voilleque, P AU - Bouville, A AD - DHHS/NIH/NCI/Division of Cancer Epidemiology and Genetics, Executive Plaza South, EPS-7094, Bethesda, MD 20892, USA, bouvilla@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 275 EP - 298 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 97 IS - 4 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Ukraine, Chernobyl KW - Reconstruction KW - Photons KW - Bone marrow KW - Decontamination KW - Mathematics KW - Computer programs KW - Workers KW - Malignancy KW - Accidents KW - thyroid cancer KW - Hematology KW - Occupational exposure KW - Data processing KW - Thyroid KW - Cancer KW - Nuclear power plants KW - Databases KW - Nuclear reactors KW - Standard deviation KW - Irradiation KW - Ionizing radiation KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20970030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=RADRUE+METHOD+FOR+RECONSTRUCTION+OF+EXTERNAL+PHOTON+DOSES+FOR+CHERNOBYL+LIQUIDATORS+IN+EPIDEMIOLOGICAL+STUDIES&rft.au=Kryuchkov%2C+V%3BChumak%2C+V%3BMaceika%2C+E%3BAnspaugh%2C+L+R%3BCardis%2C+E%3BBakhanova%2C+E%3BGolovanov%2C+I%3BDrozdovitch%2C+V%3BLuckyanov%2C+N%3BKesminiene%2C+A%3BVoilleque%2C+P%3BBouville%2C+A&rft.aulast=Kryuchkov&rft.aufirst=V&rft.date=2009-10-01&rft.volume=97&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Data processing; Photons; Reconstruction; Bone marrow; Decontamination; Mathematics; Databases; Workers; Computer programs; Nuclear power plants; Accidents; Malignancy; Standard deviation; Ionizing radiation; thyroid cancer; Nuclear reactors; Irradiation; Thyroid; Hematology; Cancer; Occupational exposure; Ukraine, Chernobyl ER - TY - JOUR T1 - The value of parsing as feature generation for gene mention recognition AN - 20967333; 11035864 AB - We measured the extent to which information surrounding a base noun phrase reflects the presence of a gene name, and evaluated seven different parsers in their ability to provide information for that purpose. Using the GENETAG corpus as a gold standard, we performed machine learning to recognize from its context when a base noun phrase contained a gene name. Starting with the best lexical features, we assessed the gain of adding dependency or dependency-like relations from a full sentence parse. Features derived from parsers improved performance in this partial gene mention recognition task by a small but statistically significant amount. There were virtually no differences between parsers in these experiments. JF - Journal of Biomedical Informatics AU - Smith, L H AU - Wilbur, W J AD - National Center for Biotechnology Information, Room 6S614-N, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, lsmith@ncbi.nlm.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 895 EP - 904 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 5 SN - 1532-0464, 1532-0464 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Statistical analysis KW - Language KW - Learning algorithms KW - Bioinformatics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=The+value+of+parsing+as+feature+generation+for+gene+mention+recognition&rft.au=Smith%2C+L+H%3BWilbur%2C+W+J&rft.aulast=Smith&rft.aufirst=L&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2009.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistical analysis; Language; Bioinformatics; Learning algorithms DO - http://dx.doi.org/10.1016/j.jbi.2009.03.011 ER - TY - JOUR T1 - Improving accuracy for identifying related PubMed queries by an integrated approach AN - 20967319; 11035855 AB - PubMed is the most widely used tool for searching biomedical literature online. As with many other online search tools, a user often types a series of multiple related queries before retrieving satisfactory results to fulfill a single information need. Meanwhile, it is also a common phenomenon to see a user type queries on unrelated topics in a single session. In order to study PubMed users' search strategies, it is necessary to be able to automatically separate unrelated queries and group together related queries. Here, we report a novel approach combining both lexical and contextual analyses for segmenting PubMed query sessions and identifying related queries and compare its performance with the previous approach based solely on concept mapping. We experimented with our integrated approach on sample data consisting of 1539 pairs of consecutive user queries in 351 user sessions. The prediction results of 1396 pairs agreed with the gold-standard annotations, achieving an overall accuracy of 90.7%. This demonstrates that our approach is significantly better than the previously published method. By applying this approach to a one day query log of PubMed, we found that a significant proportion of information needs involved more than one PubMed query, and that most of the consecutive queries for the same information need are lexically related. Finally, the proposed PubMed distance is shown to be an accurate and meaningful measure for determining the contextual similarity between biological terms. The integrated approach can play a critical role in handling real-world PubMed query log data as is demonstrated in our experiments. JF - Journal of Biomedical Informatics AU - Lu, Z AU - Wilbur, W J AD - National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA, luzh@ncbi.nlm.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 831 EP - 838 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 5 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Language KW - Mapping KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Improving+accuracy+for+identifying+related+PubMed+queries+by+an+integrated+approach&rft.au=Lu%2C+Z%3BWilbur%2C+W+J&rft.aulast=Lu&rft.aufirst=Z&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2008.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Language; Bioinformatics; Mapping DO - http://dx.doi.org/10.1016/j.jbi.2008.12.006 ER - TY - JOUR T1 - A recent advance in the automatic indexing of the biomedical literature AN - 20962050; 11035856 AB - The volume of biomedical literature has experienced explosive growth in recent years. This is reflected in the corresponding increase in the size of MEDLINE super(()R), the largest bibliographic database of biomedical citations. Indexers at the US National Library of Medicine (NLM) need efficient tools to help them accommodate the ensuing workload. After reviewing issues in the automatic assignment of Medical Subject Headings (MeSH super(()R) terms) to biomedical text, we focus more specifically on the new subheading attachment feature for NLM's Medical Text Indexer (MTI). Natural Language Processing, statistical, and machine learning methods of producing automatic MeSH main heading/subheading pair recommendations were assessed independently and combined. The best combination achieves 48% precision and 30% recall. After validation by NLM indexers, a suitable combination of the methods presented in this paper was integrated into MTI as a subheading attachment feature producing MeSH indexing recommendations compliant with current state-of-the-art indexing practice. JF - Journal of Biomedical Informatics AU - Neveol, A AU - Shooshan, SE AU - Humphrey, S M AU - Mork, J G AU - Aronson, A R AD - US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA, neveola@nlm.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 814 EP - 823 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 5 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Statistics KW - Language KW - Learning algorithms KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=A+recent+advance+in+the+automatic+indexing+of+the+biomedical+literature&rft.au=Neveol%2C+A%3BShooshan%2C+SE%3BHumphrey%2C+S+M%3BMork%2C+J+G%3BAronson%2C+A+R&rft.aulast=Neveol&rft.aufirst=A&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2008.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Statistics; Language; Bioinformatics; Learning algorithms DO - http://dx.doi.org/10.1016/j.jbi.2008.12.007 ER - TY - JOUR T1 - Automatic summarization of MEDLINE citations for evidence-based medical treatment: A topic-oriented evaluation AN - 20958662; 11035851 AB - As the number of electronic biomedical textual resources increases, it becomes harder for physicians to find useful answers at the point of care. Information retrieval applications provide access to databases; however, little research has been done on using automatic summarization to help navigate the documents returned by these systems. After presenting a semantic abstraction automatic summarization system for MEDLINE citations, we concentrate on evaluating its ability to identify useful drug interventions for 53 diseases. The evaluation methodology uses existing sources of evidence-based medicine as surrogates for a physician-annotated reference standard. Mean average precision (MAP) and a clinical usefulness score developed for this study were computed as performance metrics. The automatic summarization system significantly outperformed the baseline in both metrics. The MAP gain was 0.17 (p<0.01) and the increase in the overall score of clinical usefulness was 0.39 (p<0.05). JF - Journal of Biomedical Informatics AU - Fiszman, M AU - Demner-Fushman, D AU - Kilicoglu, H AU - Rindflesch, T C AD - National Institutes of Health, 8600 Rockville Pike, Bldg 38A, Rm B1N-28J, Bethesda, MD 20894, USA, fiszmanm@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 801 EP - 813 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 5 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Information processing KW - Bioinformatics KW - Drugs KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20958662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Automatic+summarization+of+MEDLINE+citations+for+evidence-based+medical+treatment%3A+A+topic-oriented+evaluation&rft.au=Fiszman%2C+M%3BDemner-Fushman%2C+D%3BKilicoglu%2C+H%3BRindflesch%2C+T+C&rft.aulast=Fiszman&rft.aufirst=M&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2008.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Information processing; Bioinformatics; Drugs; Semantics DO - http://dx.doi.org/10.1016/j.jbi.2008.10.002 ER - TY - JOUR T1 - What can natural language processing do for clinical decision support? AN - 20955652; 11035870 AB - Computerized clinical decision support (CDS) aims to aid decision making of health care providers and the public by providing easily accessible health-related information at the point and time it is needed. natural language processing (NLP) is instrumental in using free-text information to drive CDS, representing clinical knowledge and CDS interventions in standardized formats, and leveraging clinical narrative. The early innovative NLP research of clinical narrative was followed by a period of stable research conducted at the major clinical centers and a shift of mainstream interest to biomedical NLP. This review primarily focuses on the recently renewed interest in development of fundamental NLP methods and advances in the NLP systems for CDS. The current solutions to challenges posed by distinct sublanguages, intended user groups, and support goals are discussed. JF - Journal of Biomedical Informatics AU - Demner-Fushman, D AU - Chapman, W W AU - McDonald, C J AD - National Institutes of Health, Bethesda, MD 20894, USA, ddemner@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 760 EP - 772 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 5 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Decision making KW - Reviews KW - Language KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20955652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=What+can+natural+language+processing+do+for+clinical+decision+support%3F&rft.au=Demner-Fushman%2C+D%3BChapman%2C+W+W%3BMcDonald%2C+C+J&rft.aulast=Demner-Fushman&rft.aufirst=D&rft.date=2009-10-01&rft.volume=42&rft.issue=5&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2009.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Decision making; Reviews; Language; Bioinformatics DO - http://dx.doi.org/10.1016/j.jbi.2009.08.007 ER - TY - JOUR T1 - Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease AN - 20834198; 10985201 AB - Botulinum neurotoxins, responsible for the neuroparalytic syndrome botulism, are the deadliest of known biological toxins. The work described in this study was based on a three-zone pharmacophore model for botulinum neurotoxin serotype A light chain inhibition. Specifically, the pharmacophore defined a separation between the overlaps of several different, non-zinc(II)-coordinating small molecule chemotypes, enabling the design and synthesis of a new structural hybrid possessing a K sub(i) = 600 nM (+/-100 nM). JF - Bioorganic and Medicinal Chemistry Letters AU - Burnett, J C AU - Wang, C AU - Nuss, JE AU - Nguyen, T L AU - Hermone, A R AU - Schmidt, J J AU - Gussio, R AU - Wipf, P AU - Bavari, S AD - SAIC Frederick, Inc., Target Structure-Based Drug Discovery Group, Frederick, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, United States, burnett.james@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 5811 EP - 5813 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 19 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Metalloproteinase KW - Light chains KW - Serotypes KW - Botulism KW - Hybrids KW - Clostridium botulinum KW - Botulinum toxin KW - pharmacophores KW - Lead KW - N3 11008:Neurochemistry KW - W 30965:Miscellaneous, Reviews KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20834198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Pharmacophore-guided+lead+optimization%3A+The+rational+design+of+a+non-zinc+coordinating%2C+sub-micromolar+inhibitor+of+the+botulinum+neurotoxin+serotype+a+metalloprotease&rft.au=Burnett%2C+J+C%3BWang%2C+C%3BNuss%2C+JE%3BNguyen%2C+T+L%3BHermone%2C+A+R%3BSchmidt%2C+J+J%3BGussio%2C+R%3BWipf%2C+P%3BBavari%2C+S&rft.aulast=Burnett&rft.aufirst=J&rft.date=2009-10-01&rft.volume=19&rft.issue=19&rft.spage=5811&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.01.111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metalloproteinase; Light chains; Serotypes; Botulism; Hybrids; Botulinum toxin; Lead; pharmacophores; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.bmcl.2009.01.111 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS) AN - 20799798; 10893282 AB - Although limited, epidemiologic studies suggest possible associations between butylate use and cancer risk, specifically prostate cancer and non-Hodgkin lymphoma (NHL). We examined butylate use and cancer risk more broadly in the AHS, a cohort of licensed pesticide applicators in Iowa and North Carolina. Pesticide use information was collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI). Two exposure metrics were used: lifetime exposure days (LD) and intensity-weighted lifetime exposure days (IWLD). We used two referent groups: unexposed to butylate and the lowest butylate usage category. This analysis included 19,655 applicators with complete butylate use information; 5297 applicators were exposed to butylate, making this the largest study of butylate to date. The mean follow-up time since enrollment was 9 years. Prostate cancer risk was significantly elevated among applicators in the highest LD category in both referent groups (low-exposed referent: RR sub(L) sub(D)=2.09, 95% CI=1.27-3.44). We observed a significantly elevated joint effect of prostate cancer family history and high butylate usage across both exposure metrics and both referent groups (low-exposed referent: RR sub(L) sub(D)=2.00, 95% CI=1.07-3.74), and a non-significant, elevated interaction between butylate use and prostate cancer family history, similar to a previous AHS finding. Statistically significant increased risks and exposure-response trends were seen for all lymphohematopoietic cancers (AL) and NHL for both exposure metrics and referent groups (low-exposed referent: AL:RR sub(L) sub(D)=2.27, 95% CI=1.18-4.37; NHL: RR sub(L) sub(D)=3.44, 95% CI=1.29-9.21). Our analysis did not find meaningful associations for other cancers analyzed. Further study is warranted for AL, NHL and prostate cancers. Oncology,2nd Edition JF - Environmental Research AU - Lynch, S M AU - Mahajan, R AU - Beane Freeman, LE AU - Hoppin, JA AU - Alavanja, MCR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA, Alavanjm@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 860 EP - 868 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 109 IS - 7 SN - 0013-9351, 0013-9351 KW - Health & Safety Science Abstracts; Risk Abstracts; Environment Abstracts KW - non-Hodgkin's lymphoma KW - USA, North Carolina KW - Genetics KW - Non-Hodgkin's lymphoma KW - Prostate cancer KW - USA, Iowa KW - Pesticides KW - prostate cancer KW - Cancer KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+butylate+in+the+Agricultural+Health+Study+%28AHS%29&rft.au=Lynch%2C+S+M%3BMahajan%2C+R%3BBeane+Freeman%2C+LE%3BHoppin%2C+JA%3BAlavanja%2C+MCR&rft.aulast=Lynch&rft.aufirst=S&rft.date=2009-10-01&rft.volume=109&rft.issue=7&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2009.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - non-Hodgkin's lymphoma; Non-Hodgkin's lymphoma; Genetics; Prostate cancer; Pesticides; prostate cancer; Occupational exposure; Cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1016/j.envres.2009.06.006 ER - TY - JOUR T1 - Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI AN - 20792362; 10854902 AB - We offer a new method for characterizing the magnitude and dynamics of the vascular response to changes in arterial gas tensions using non-invasive blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) and paradigms appropriate for clinical settings. A novel respiratory task, "Cued Deep Breathing" (CDB), consisting of two consecutive cycles of cued breaths, has been developed to cause transient hypocapnia, and consequently a strong, short-lived BOLD signal decrease. Data from CDB hypocapnia paradigms and traditional breath-holding hypercapnia paradigms were analyzed on a voxel-wise basis to map regional heterogeneity in magnitude and timing parameters. The tasks caused comparable absolute BOLD percent signal changes ([not, vert, similar] 0.5-3.0% in gray matter) and both datasets suggested consistent regional heterogeneity in the response timing: parts of the basal ganglia, particularly the putamen, and bilateral areas of medial cortex reached their maximum signal change several seconds earlier than remaining cortical gray matter voxels. This phenomenon and a slightly delayed response in posterior cortical regions were present in group-maps of ten healthy subjects. An auxiliary experiment in different subjects measured end-tidal CO sub(2) changes associated with the new CDB task and quantitatively compared the resulting reactivity maps with those acquired using a traditional hypercapnia challenge of 4% CO sub(2) gas inspiration. The CDB task caused average end-tidal CO sub(2) decreases between 6.0 +/- 1.1 and 10.5 +/- 2.6 mm Hg, with levels returning to baseline after approximately three breaths, giving evidence that the task indeed causes transient mild hypocapnia. Similarity between resulting reactivity maps suggest CDB offers an alternative method for mapping cerebrovascular reactivity. JF - NeuroImage AU - Bright, Molly G AU - Bulte, Daniel P AU - Jezzard, Peter AU - Duyn, Jeff H AD - Laboratory for Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, molly.bright@clneuro.ox.ac.uk Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 166 EP - 175 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 48 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - fMRI KW - Reactivity KW - BOLD KW - Dynamics KW - Breath-holding KW - Hypocapnia KW - Hypercapnia KW - Deep breathing KW - Neuroimaging KW - Data processing KW - Respiration KW - Functional magnetic resonance imaging KW - Putamen KW - Delayed response KW - Cortex KW - Mapping KW - Carbon dioxide KW - Basal ganglia KW - Vascular system KW - Substantia grisea KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20792362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Characterization+of+regional+heterogeneity+in+cerebrovascular+reactivity+dynamics+using+novel+hypocapnia+task+and+BOLD+fMRI&rft.au=Bright%2C+Molly+G%3BBulte%2C+Daniel+P%3BJezzard%2C+Peter%3BDuyn%2C+Jeff+H&rft.aulast=Bright&rft.aufirst=Molly&rft.date=2009-10-01&rft.volume=48&rft.issue=1&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Hypercapnia; Functional magnetic resonance imaging; Respiration; Putamen; Delayed response; Cortex; Mapping; Carbon dioxide; Basal ganglia; Substantia grisea; Vascular system DO - http://dx.doi.org/10.1016/j.neuroimage.2009.05.026 ER - TY - JOUR T1 - Functional but not structural changes associated with learning: An exploration of longitudinal Voxel- Based Morphometry (VBM) AN - 20792319; 10854897 AB - Voxel-Based Morphometry (VBM) has been used for several years to study differences in brain structure between populations. Recently, a longitudinal version of VBM has been used to show changes in gray matter associated with relatively short periods of training. In the present study we use fMRI and three different standard implementations of longitudinal VBM: SPM2, FSL, and SPM5 to assess functional and structural changes associated with a simple learning task. Behavioral and fMRI data clearly showed a significant learning effect. However, initially positive VBM results were found to be inconsistent across minor perturbations of the analysis technique and ultimately proved to be artifactual. When alignment biases were controlled for and recommended statistical procedures were used, no significant changes in grey matter density were found. This work, initially intended to show structural and functional changes with learning, rather demonstrates some of the potential pitfalls of existing longitudinal VBM methods and prescribes that these tools be applied and interpreted with extreme caution. JF - NeuroImage AU - Thomas, Adam G AU - Marrett, Sean AU - Saad, Ziad S AU - Ruff, Douglas A AU - Martin, Alex AU - Bandettini, Peter A AD - Functional MRI Facility, NIMH, Bethesda, MD, USA, adamt@nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 117 EP - 125 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 48 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Learning KW - Neuroimaging KW - Statistics KW - Data processing KW - Structure-function relationships KW - Morphometry KW - Functional magnetic resonance imaging KW - Substantia grisea KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20792319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Functional+but+not+structural+changes+associated+with+learning%3A+An+exploration+of+longitudinal+Voxel-+Based+Morphometry+%28VBM%29&rft.au=Thomas%2C+Adam+G%3BMarrett%2C+Sean%3BSaad%2C+Ziad+S%3BRuff%2C+Douglas+A%3BMartin%2C+Alex%3BBandettini%2C+Peter+A&rft.aulast=Thomas&rft.aufirst=Adam&rft.date=2009-10-01&rft.volume=48&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.05.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Learning; Data processing; Statistics; Morphometry; Structure-function relationships; Functional magnetic resonance imaging; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2009.05.097 ER - TY - JOUR T1 - The influence of context valence in the neural coding of monetary outcomes AN - 20703694; 10854913 AB - The emotional significance of objects and events depends on the context in which they occur. Using functional magnetic resonance imaging, we examined the modulation of neural responses to monetary outcomes while subjects performed a decision-making task in a positive and a negative economic context. Neural responses indicated a relative regional specialization in the neural coding of outcome valence and followed three distinct patterns. The nucleus accumbens (NAc) and orbital frontal cortex (OFC) appeared to code the most extreme outcome in each context, with a potentiated response for favorable outcomes by a positive context. The amygdala and insula appeared to also code highly salient outcomes, but showed a potentiated response to unfavorable outcomes occurring in a negative context. The medial prefrontal cortex (medPFC), on the other hand, only coded favorable responses occurring in a positive context. Moreover, the medPFC showed large inter-individual variability when responding to outcomes in a negative context, suggesting that its role in a negative context may depend on a number of individual factors. The results of this work provide evidence of complex valence-based regional dissociations that are influenced by contextual factors. JF - NeuroImage AU - Hardin, Michael G AU - Pine, Daniel S AU - Ernst, Monique AD - Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, NIH/DHHS, USA, ernstm@mail.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 249 EP - 257 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 48 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Coding KW - Emotions KW - Nucleus accumbens KW - Decision making KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Economics KW - Cortex (frontal) KW - Specialization KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20703694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+influence+of+context+valence+in+the+neural+coding+of+monetary+outcomes&rft.au=Hardin%2C+Michael+G%3BPine%2C+Daniel+S%3BErnst%2C+Monique&rft.aulast=Hardin&rft.aufirst=Michael&rft.date=2009-10-01&rft.volume=48&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.06.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Decision making; Nucleus accumbens; Emotions; Coding; Neuroimaging; Functional magnetic resonance imaging; Economics; Specialization; Cortex (frontal); Amygdala; Cortex (prefrontal) DO - http://dx.doi.org/10.1016/j.neuroimage.2009.06.050 ER - TY - JOUR T1 - Visiting Entertainment Venues and Sexual Health in China AN - 205938307; 18256918 AB - Entertainment venues in China are associated with risky sexual behavior. Most previous studies related to entertainment venues in China have focused on sex workers and commercial sex, but this study addressed sexual health in a sample of the general urban population. A randomly selected sample of market vendors (n = 4,510) from an eastern city was recruited and assessed to examine relationships between entertainment venue visits and sexual risk. Both behavioral (self-reports of unprotected sex) and biomedical (STD test results) measures were used. About 18% of the sample (26.8% of men and 9% of women) reported visiting entertainment venues in the past 30 days. Those who visited entertainment venues were more likely to be male, younger, single, with higher education, and to have more discretionary income. For both men and women, visiting entertainment venues was a significant predictor for unprotected sex and STD infection. Gender differences were observed in predicting unprotected sex and STD infections. Entertainment venues could be potential sites for place-based intervention programs and outreach for the general population. [PUBLICATION ABSTRACT] JF - Archives of Sexual Behavior AU - Li, Li AU - Wu, Zunyou AU - Rotheram-borus, Mary Jane AU - Guan, Jihui AU - Yin, Yueping AU - Detels, Roger AU - Wu, Sheng AU - Lee, Sung-jae AU - Cao, Haijun AU - Lin, Chunqing AU - Rou, Keming AU - Liu, Zhendong Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 814 EP - 20 CY - New York PB - Springer Science & Business Media VL - 38 IS - 5 SN - 00040002 KW - Medical Sciences KW - Sexual behavior KW - Sexually transmitted diseases--STD KW - Human immunodeficiency virus--HIV KW - Sex industry KW - China KW - Questionnaires KW - Sex Characteristics KW - Computers KW - Humans KW - Alcohol Drinking -- epidemiology KW - Sexually Transmitted Diseases -- epidemiology KW - Socioeconomic Factors KW - Marital Status KW - Education KW - Logistic Models KW - Adult KW - Interviews as Topic KW - Female KW - Male KW - Sexual Behavior KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/205938307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Visiting+Entertainment+Venues+and+Sexual+Health+in+China&rft.au=Li%2C+Li%3BWu%2C+Zunyou%3BRotheram-borus%2C+Mary+Jane%3BGuan%2C+Jihui%3BYin%2C+Yueping%3BDetels%2C+Roger%3BWu%2C+Sheng%3BLee%2C+Sung-jae%3BCao%2C+Haijun%3BLin%2C+Chunqing%3BRou%2C+Keming%3BLiu%2C+Zhendong&rft.aulast=Li&rft.aufirst=Li&rft.date=2009-10-01&rft.volume=38&rft.issue=5&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/10.1007%2Fs10508-008-9311-7 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2009 N1 - Document feature - References N1 - Last updated - 2014-09-25 N1 - CODEN - ASXBA8 N1 - SubjectsTermNotLitGenreText - China DO - http://dx.doi.org/10.1007/s10508-008-9311-7 ER - TY - JOUR T1 - Purification of capping protein using the capping protein binding site of CARMIL as an affinity matrix AN - 20220967; 10320825 AB - Capping protein (CP) is a ubiquitously expressed, heterodimeric actin binding protein that is essential for normal actin dynamics in cells. The existing methods for purifying native CP from tissues and recombinant CP from bacteria are time-consuming processes that involve numerous conventional chromatographic steps and functional assays to achieve a homogeneous preparation of the protein. Here, we report the rapid purification of Acanthamoeba CP from amoeba extracts and recombinant mouse CP from E. coli extracts using as an affinity matrix GST-fusion proteins containing the CP binding site from Acanthamoeba CARMIL and mouse CARMIL-1, respectively. This improved method for CP purification should facilitate the in vitro analysis of CP structure, function, and regulation. JF - Protein Expression and Purification AU - Remmert, Kirsten AU - Uruno, Takehito AU - Hammer, John A AD - Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, hammerj@nhlbi.nih.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 113 EP - 119 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 67 IS - 2 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Capping protein KW - CARMIL KW - Affinity matrix KW - CAH3 domain KW - Acanthamoeba KW - Structure-function relationships KW - Escherichia coli KW - Amoeba KW - Actin KW - protein purification KW - J 02330:Biochemistry KW - K 03300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20220967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Purification+of+capping+protein+using+the+capping+protein+binding+site+of+CARMIL+as+an+affinity+matrix&rft.au=Remmert%2C+Kirsten%3BUruno%2C+Takehito%3BHammer%2C+John+A&rft.aulast=Remmert&rft.aufirst=Kirsten&rft.date=2009-10-01&rft.volume=67&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2009.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Structure-function relationships; Actin; protein purification; Acanthamoeba; Escherichia coli; Amoeba DO - http://dx.doi.org/10.1016/j.pep.2009.05.002 ER - TY - JOUR T1 - Postnatal Cadmium Exposure, Neurodevelopment, and Blood Pressure in Children at 2, 5, and 7 Years of Age AN - 1677983979; 11866562 AB - Background Adverse health effects of cadmium in adults are well documented, but little is known about the neuropsychological effects of cadmium in children, and no studies of cadmium and blood pressure in children have been conducted. Objective We examined the potential effects of low-level cadmium exposure on intelligence quotient, neuropsychological functions, behavior, and blood pressure among children, using blood cadmium as a measure of exposure. Methods We used the data from a multicenter randomized clinical trial of lead-exposed children and analyzed blood cadmium concentrations using the whole blood samples collected when children were 2 years of age. We compared neuropsychological and behavioral scores at 2, 5, and 7 years of age by cadmium level and analyzed the relationship between blood cadmium levels at 2 years of age and systolic and diastolic blood pressure at 2, 5, and 7 years of age. Results The average cadmium concentration of these children was 0.21 I14g/L, lower than for adults in the National Health and Nutrition Examination Survey (NHANES), but comparable to concentrations in children & 3 years of age in NHANES. Except for the California Verbal Learning Test for Children, there were no differences in test scores among children in different cadmium categories. For children with detectable pretreatment blood cadmium, after adjusting for a variety of covariates, general linear model analyses showed that at none of the three age points was the coefficient of cadmium on Mental Development Index or IQ statistically significant. Spline regression analysis suggested that behavioral problem scores at 5 and 7 years of age tended to increase with increasing blood cadmium, but the trend was not significant. We found no significant associations between blood cadmium levels and blood pressure. Conclusion We found no significant associations between background blood cadmium levels at 2 years of age and neurodevelopmental end points and blood pressure at 2, 5, and 7 years of age. The neuropsychological or hypertensive effects from longer background exposures to cadmium need further study. JF - Environmental Health Perspectives AU - Cao, Yang AU - Chen, Aimin AU - Radcliffe, Jerilynn AU - Dietrich, Kim N AU - Jones, Robert L AU - Caldwell, Kathleen AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1580 EP - 1586 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 10 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - behavior KW - blood pressure KW - cadmium KW - children KW - clinical trial KW - intelligence KW - neurodevelopment KW - Blood KW - Age KW - Regression analysis KW - Health KW - Cadmium KW - Adults KW - Children KW - Blood pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677983979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Postnatal+Cadmium+Exposure%2C+Neurodevelopment%2C+and+Blood+Pressure+in+Children+at+2%2C+5%2C+and+7+Years+of+Age&rft.au=Cao%2C+Yang%3BChen%2C+Aimin%3BRadcliffe%2C+Jerilynn%3BDietrich%2C+Kim+N%3BJones%2C+Robert+L%3BCaldwell%2C+Kathleen%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2009-10-01&rft.volume=117&rft.issue=10&rft.spage=1580&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0900765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.0900765 ER - TY - JOUR T1 - Antibody-based therapy of leukaemia. AN - 734063835; 19788782 AB - Over the past decade, monoclonal antibodies have dramatically impacted the treatment of haematological malignancies, as evidenced by the effect of rituximab on the response rate and survival of patients with follicular and diffuse large B cell non-Hodgkin's lymphoma. Currently, only two monoclonal antibodies - the anti-CD33 immunotoxin gemtuzumab ozogamicin and the CD52-directed antibody alemtuzumab - are approved for treatment of relapsed acute myeloid leukaemia in older patients and B cell chronic lymphocytic leukaemia, respectively. Although not approved for such treatment, alemtuzumab is also active against T cell prolymphocytic leukaemia, cutaneous T cell lymphoma and Sézary syndrome, and adult T cell leukaemia and lymphoma. In addition, rituximab has demonstrated activity against B cell chronic lymphocytic and hairy cell leukaemia. Monoclonal antibodies targeting CD4, CD19, CD20, CD22, CD23, CD25, CD45, CD66 and CD122 are now being studied in the clinic for the treatment of leukaemia. Here, we discuss how these new antibodies have been engineered to reduce immunogenicity and improve antibody targeting and binding. Improved interactions with Fc receptors on immune effector cells can enhance destruction of target cells through antibody-dependent cellular cytotoxicity and complement-mediated cell lysis. The antibodies can also be armed with cellular toxins or radionuclides to enhance the destruction of leukaemia cells. JF - Expert reviews in molecular medicine AU - Morris, John C AU - Waldmann, Thomas A AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1457, USA. jmorris@mail.nih.gov Y1 - 2009/09/30/ PY - 2009 DA - 2009 Sep 30 SP - 1 VL - 11 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Immunologic Factors KW - Immunotoxins KW - Index Medicus KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Antigens, CD -- immunology KW - Hematologic Neoplasms -- therapy KW - Leukemia -- therapy KW - Leukemia -- immunology KW - Immunologic Factors -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734063835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+reviews+in+molecular+medicine&rft.atitle=Antibody-based+therapy+of+leukaemia.&rft.au=Morris%2C+John+C%3BWaldmann%2C+Thomas+A&rft.aulast=Morris&rft.aufirst=John&rft.date=2009-09-30&rft.volume=11&rft.issue=&rft.spage=e29&rft.isbn=&rft.btitle=&rft.title=Expert+reviews+in+molecular+medicine&rft.issn=1462-3994&rft_id=info:doi/10.1017%2FS1462399409001215 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-24 N1 - Date created - 2009-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S1462399409001215 ER - TY - JOUR T1 - Assessing cumulative incidence functions under the semiparametric additive risk model AN - 1017966750; 16691458 AB - In analyzing competing risks data, a quantity of considerable interest is the cumulative incidence function. Often, the effect of covariates on the cumulative incidence function is modeled via the proportional hazards model for the cause-specific hazard function. As the proportionality assumption may be too restrictive in practice, we consider an alternative more flexible semiparametric additive hazards model of (Biometrika 1994; 81:501-514) for the cause-specific hazard. This model specifies the effect of covariates on the cause-specific hazard to be additive as well as allows the effect of some covariates to be fixed and that of others to be time varying. We present an approach for constructing confidence intervals as well as confidence bands for the cause-specific cumulative incidence function of subjects with given values of the covariates. Furthermore, we also present an approach for constructing confidence intervals and confidence bands for comparing two cumulative incidence functions given values of the covariates. The finite sample property of the proposed estimators is investigated through simulations. We conclude our paper with an analysis of the well-known malignant melanoma data using our method. Published in 2009 by John Wiley & Sons, Ltd. JF - Statistics in Medicine AU - Hyun, Seunggeun AU - Sun, Yanqing AU - Sundaram, Rajeshwari AD - Division of Mathematics and Computer Science, University of South Carolina Upstate, Spartanburg, SC 29303, U.S.A., sundaramr2@mail.nih.gov Y1 - 2009/09/30/ PY - 2009 DA - 2009 Sep 30 SP - 2748 EP - 2768 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 22 SN - 1097-0258, 1097-0258 KW - Risk Abstracts KW - Additives KW - Simulation KW - melanoma KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=Assessing+cumulative+incidence+functions+under+the+semiparametric+additive+risk+model&rft.au=Hyun%2C+Seunggeun%3BSun%2C+Yanqing%3BSundaram%2C+Rajeshwari&rft.aulast=Hyun&rft.aufirst=Seunggeun&rft.date=2009-09-30&rft.volume=28&rft.issue=22&rft.spage=2748&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.3640 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.3640/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Simulation; melanoma; Additives DO - http://dx.doi.org/10.1002/sim.3640 ER - TY - JOUR T1 - Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. AN - 733610949; 19540312 AB - An acute brain insult such as traumatic head/brain injury, stroke, or an episode of status epilepticus can trigger epileptogenesis, which, after a latent, seizure-free period, leads to epilepsy. The discovery of effective pharmacological interventions that can prevent the development of epilepsy requires knowledge of the alterations that occur during epileptogenesis in brain regions that play a central role in the induction and expression of epilepsy. In the present study, we investigated pathological alterations in GABAergic interneurons in the rat basolateral amygdala (BLA), and the functional impact of these alterations on inhibitory synaptic transmission, on days 7 to 10 after status epilepticus induced by kainic acid. Using design-based stereology combined with glutamic acid decarboxylase (GAD) 67 immunohistochemistry, we found a more extensive loss of GABAergic interneurons compared to the loss of principal cells. Fluoro-Jade C staining showed that neuronal degeneration was still ongoing. These alterations were accompanied by an increase in the levels of GAD and the alpha1 subunit of the GABA(A) receptor, and a reduction in the GluK1 (previously known as GluR5) subunit, as determined by Western blots. Whole-cell recordings from BLA pyramidal neurons showed a significant reduction in the frequency and amplitude of action potential-dependent spontaneous inhibitory postsynaptic currents (IPSCs), a reduced frequency but not amplitude of miniature IPSCs, and impairment in the modulation of IPSCs via GluK1-containing kainate receptors (GluK1Rs). Thus, in the BLA, GABAergic interneurons are more vulnerable to seizure-induced damage than principal cells. Surviving interneurons increase their expression of GAD and the alpha1 GABA(A) receptor subunit, but this does not compensate for the interneuronal loss; the result is a dramatic reduction of tonic inhibition in the BLA circuitry. As activation of GluK1Rs by ambient levels of glutamate facilitates GABA release, the reduced level and function of these receptors may contribute to the reduction of tonic inhibitory activity. These alterations at a relatively early stage of epileptogenesis may facilitate the progress towards the development of epilepsy. JF - Neuroscience AU - Fritsch, B AU - Qashu, F AU - Figueiredo, T H AU - Aroniadou-Anderjaska, V AU - Rogawski, M A AU - Braga, M F M AD - Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/09/29/ PY - 2009 DA - 2009 Sep 29 SP - 415 EP - 429 VL - 163 IS - 1 KW - Convulsants KW - 0 KW - Fluoresceins KW - Gabra1 protein, rat KW - Gluk1 kainate receptor KW - Organic Chemicals KW - Receptors, GABA-A KW - Receptors, Kainic Acid KW - fluoro jade KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Glutamate Decarboxylase KW - EC 4.1.1.15 KW - glutamate decarboxylase 1 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Kainic Acid -- pharmacology KW - Glutamic Acid -- metabolism KW - Status Epilepticus -- physiopathology KW - Receptors, Kainic Acid -- metabolism KW - Convulsants -- pharmacology KW - Status Epilepticus -- pathology KW - Synaptic Transmission -- physiology KW - Inhibitory Postsynaptic Potentials -- physiology KW - Glutamate Decarboxylase -- metabolism KW - Rats KW - Status Epilepticus -- chemically induced KW - Rats, Sprague-Dawley KW - Down-Regulation -- physiology KW - Patch-Clamp Techniques KW - Receptors, GABA-A -- metabolism KW - Staining and Labeling KW - Immunohistochemistry KW - Male KW - Epilepsy -- pathology KW - Epilepsy -- physiopathology KW - Amygdala -- physiopathology KW - Amygdala -- metabolism KW - Interneurons -- metabolism KW - Interneurons -- pathology KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Epilepsy -- metabolism KW - gamma-Aminobutyric Acid -- metabolism KW - Amygdala -- pathology KW - Neural Inhibition -- physiology KW - Nerve Degeneration -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733610949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Pathological+alterations+in+GABAergic+interneurons+and+reduced+tonic+inhibition+in+the+basolateral+amygdala+during+epileptogenesis.&rft.au=Fritsch%2C+B%3BQashu%2C+F%3BFigueiredo%2C+T+H%3BAroniadou-Anderjaska%2C+V%3BRogawski%2C+M+A%3BBraga%2C+M+F+M&rft.aulast=Fritsch&rft.aufirst=B&rft.date=2009-09-29&rft.volume=163&rft.issue=1&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.06.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 1999;94(2):473-95 [10579210] Epilepsy Res. 2000 Apr;39(2):133-52 [10759302] J Chem Neuroanat. 2000 Oct;20(1):93-114 [11074347] Neuroscience. 2000;101(2):377-91 [11074161] Mil Med. 1996 Jan;161(1):61-4 [11082755] Br J Pharmacol. 2000 Dec;131(7):1251-4 [11090095] Nat Neurosci. 2001 Jan;4(1):52-62 [11135645] Nat Neurosci. 2001 Jun;4(6):612-20 [11369942] Neurobiol Dis. 2001 Jun;8(3):459-68 [11442354] Nat Neurosci. 2002 Aug;5(8):796-804 [12080343] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15078-83 [12409614] J Neurosci. 2003 Jan 15;23(2):442-52 [12533604] J Neurosci. 2003 Mar 15;23(6):2440-52 [12657704] Ann N Y Acad Sci. 2003 Apr;985:150-62 [12724156] Epilepsia. 2003 May;44(5):647-58 [12752463] J Neurosci. 2003 Aug 6;23(18):7069-74 [12904467] Eur J Neurosci. 2003 Oct;18(8):2213-26 [14622182] Neuropharmacology. 2004 Jun;46(8):1097-104 [15111016] Epilepsia. 2004 Sep;45(9):1024-34 [15329065] Mol Neurobiol. 2004 Oct;30(2):127-41 [15475623] Nature. 1967 Jun 3;214(5092):1020-1 [6055396] Exp Neurol. 1969 Nov;25(3):295-330 [4981856] Neurology. 1980 Jul;30(7 Pt 1):683-9 [7190235] Neuroscience. 1983 Dec;10(4):1301-15 [6141539] Brain Res. 1984 Nov 19;322(1):101-10 [6518361] Neurology. 1985 Oct;35(10):1406-14 [3929158] Epilepsia. 1986;27 Suppl 2:S27-45 [3720711] Science. 1987 Jan 2;235(4784):73-6 [2879352] Brain Res. 1988 Jun 28;454(1-2):264-74 [3409010] J Comp Neurol. 1989 Feb 8;280(2):183-96 [2925892] Trends Neurosci. 1988 Oct;11(10):438-43 [2469161] Neurosci Lett. 1989 May 22;100(1-3):53-8 [2569703] Brain Res. 1989 Aug 7;494(1):177-81 [2670063] Science. 1989 Oct 13;246(4927):257-60 [2508225] Neuron. 1990 Nov;5(5):583-95 [1977421] Ann Neurol. 1991 May;29(5):529-41 [1650160] Neurochem Res. 1991 Mar;16(3):215-26 [1780024] Brain Res Bull. 1992 Jan;28(1):27-38 [1347249] J Neurosurg. 1992 Aug;77(2):185-93 [1625005] J Neurosci. 1992 Dec;12(12):4846-53 [1464770] Neurology. 1993 Apr;43(4):719-25 [8469329] Ann Neurol. 1993 Jun;33(6):622-31 [8498843] Neurosci Lett. 1993 May 28;155(1):1-6 [8361655] J Neurosci. 1993 Oct;13(10):4470-85 [8410199] Neurology. 1993 Oct;43(10):1998-2006 [8413957] J Neurosci. 1993 Nov;13(11):4787-809 [8229199] J Neurosci. 1993 Nov;13(11):4810-30 [8229200] Ann Neurol. 1993 Dec;34(6):774-80 [8250525] J Neurosci. 1994 Mar;14(3 Pt 2):1834-55 [8126575] Brain. 1995 Feb;118 ( Pt 1):105-18 [7894997] Exp Brain Res. 1995;102(3):423-8 [7737389] Epilepsy Res. 1996 Apr;23(3):179-87 [8739121] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9665-9 [8790388] Epilepsy Res. 1996 Sep;25(1):51-7 [8886661] Epilepsy Res. 1996 Dec;26(1):207-18 [8985701] Eur J Neurosci. 1996 Dec;8(12):2711-25 [8996821] Neurosci Lett. 1997 Jan 24;222(1):1-4 [9121710] Epilepsy Res. 1997 Jan;26(2):315-27 [9095393] J Neurophysiol. 1997 Apr;77(4):1924-38 [9114245] Acta Neuropathol. 1997 Jun;93(6):606-10 [9194900] Neuroscience. 1997 Oct;80(4):1001-17 [9284056] Neuroscience. 1997 Oct;80(4):1019-32 [9284057] J Comp Neurol. 1997 Sep 1;385(3):385-404 [9300766] Nature. 1997 Oct 9;389(6651):599-603 [9335499] Epilepsy Res. 1998 Jun;31(1):73-84 [9696302] Nature. 1998 Sep 10;395(6698):172-7 [9744275] Epilepsy Res. 1998 Sep;32(1-2):233-53 [9761324] Nat Med. 1998 Oct;4(10):1166-72 [9771750] Epilepsy Res. 1998 Nov;32(3):363-9 [9839776] Neurobiol Dis. 1998 Sep;5(3):151-76 [9848088] Trends Pharmacol Sci. 1998 Dec;19(12):500-5 [9871412] Epilepsia. 1999 Apr;40(4):453-61 [10219271] J Microsc. 1999 Mar;193(Pt 3):199-211 [10348656] Neurochem Int. 1999 May;34(5):435-45 [10397372] Epilepsia. 1999;40 Suppl 1:S23-33; discussion S40-1 [10421558] Nat Neurosci. 1999 Jun;2(6):499-500 [10448211] Epilepsia. 1999 Sep;40(9):1222-30 [10487184] Neurosignals. 2004 Nov-Dec;13(6):290-7 [15627816] Epilepsia. 2005 May;46(5):616-23 [15857425] Epilepsia. 2005;46 Suppl 5:3-9 [15987246] Epilepsia. 2005;46 Suppl 5:59-63 [15987255] J Neurophysiol. 2005 Aug;94(2):952-60 [15772233] J Comp Neurol. 2006 Feb 20;494(6):944-60 [16385488] J Neurophysiol. 2006 Apr;95(4):2143-54 [16381802] Dev Neurosci. 2006;28(4-5):354-63 [16943659] Epilepsia. 2006 Oct;47(10):1665-73 [17054689] J Comp Neurol. 2007 Jan 20;500(3):513-29 [17120289] J Comp Neurol. 2007 Feb 10;500(5):876-93 [17177260] J Physiol. 2007 Jan 1;578(Pt 1):193-211 [17008374] J Neurosci. 2007 Mar 14;27(11):2999-3009 [17360923] Amino Acids. 2007;32(3):305-15 [17048126] Crit Rev Neurobiol. 2006;18(1-2):197-203 [17725522] Epilepsia. 2007 Oct;48(10):1883-94 [17559569] Curr Med Chem. 2007;14(25):2680-701 [17979718] Brain Res. 2007 Nov 21;1181:104-17 [17919468] Epilepsy Res. 2008 Feb;78(2-3):102-16 [18226499] Neuroscience. 2009 Mar 3;159(1):380-9 [19136046] Hippocampus. 2003;13(5):633-45 [12921352] Nature. 1999 Oct 21;401(6755):796-800 [10548105] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2009.06.034 ER - TY - JOUR T1 - In vivo multiple color lymphatic imaging using upconverting nanocrystals AN - 21083588; 11087177 AB - Upconverting nanocrystals are unique nano-sized particles that emit light at shorter wavelengths (visible and near infrared) after excitation in the near infrared that dramatically reduces background autofluorescence in in vivo two color lymphatic imaging for depicting the lymphatic channels and nodes. JF - Journal of Materials Chemistry AU - Kobayashi, H AU - Kosaka, N AU - Ogawa, M AU - Morgan, N Y AU - Smith, P D AU - Murray, C B AU - Ye, X AU - Collins, J AU - Kumar, G A AU - Bell, H AU - Choyke, P L AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bldg. 10, Room 1B40, MSC 1088, Bethesda, MD 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2009/09/28/ PY - 2009 DA - 2009 Sep 28 SP - 6481 EP - 6484 VL - 19 IS - 36 SN - 0959-9428, 0959-9428 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Crystals KW - imaging KW - Light effects KW - Color KW - Wavelength KW - Nodes KW - W 30910:Imaging KW - F 06900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21083588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Materials+Chemistry&rft.atitle=In+vivo+multiple+color+lymphatic+imaging+using+upconverting+nanocrystals&rft.au=Kobayashi%2C+H%3BKosaka%2C+N%3BOgawa%2C+M%3BMorgan%2C+N+Y%3BSmith%2C+P+D%3BMurray%2C+C+B%3BYe%2C+X%3BCollins%2C+J%3BKumar%2C+G+A%3BBell%2C+H%3BChoyke%2C+P+L&rft.aulast=Kobayashi&rft.aufirst=H&rft.date=2009-09-28&rft.volume=19&rft.issue=36&rft.spage=6481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Materials+Chemistry&rft.issn=09599428&rft_id=info:doi/10.1039%2Fb910512c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Crystals; imaging; Color; Nodes; Light effects; Wavelength DO - http://dx.doi.org/10.1039/b910512c ER - TY - JOUR T1 - Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines. AN - 67648809; 19654066 AB - Recombinant modified vaccinia virus Ankara (rMVA) expressing HIV-1 genes are promising vaccine candidates. Toward the goal of conducting clinical trials with one or a cocktail of recombinant viruses, four rMVAs expressing env and gag-pol genes from primary HIV-1 isolates representing predominant subtypes from Kenya, Tanzania, Uganda, and Thailand (A, C, D, and CRF01_AE, respectively) were constructed. Efficient expression, processing, and function of Env and Gag were demonstrated. All inserted genes were shown to be genetically stable after repeated passage in cell culture. Strong HIV-specific cellular and humoral immune responses were elicited in mice immunized with each individual vaccine candidate. The MVA/CMDR vaccine candidate expressing CRF01_AE genes has elicited HIV-specific T-cell responses in two independent Phase I clinical trials. Further testing of the other rMVA is warranted. JF - Vaccine AU - Earl, Patricia L AU - Cotter, Catherine AU - Moss, Bernard AU - VanCott, Thomas AU - Currier, Jeffrey AU - Eller, Leigh Anne AU - McCutchan, Francine AU - Birx, Deborah L AU - Michael, Nelson L AU - Marovich, Mary A AU - Robb, Merlin AU - Cox, Josephine H AD - Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA. pearl@niaid.nih.gov Y1 - 2009/09/25/ PY - 2009 DA - 2009 Sep 25 SP - 5885 EP - 5895 VL - 27 IS - 42 KW - AIDS Vaccines KW - 0 KW - HIV Antibodies KW - env Gene Products, Human Immunodeficiency Virus KW - gag Gene Products, Human Immunodeficiency Virus KW - Index Medicus KW - Animals KW - Spleen -- cytology KW - Humans KW - Mice KW - gag Gene Products, Human Immunodeficiency Virus -- immunology KW - env Gene Products, Human Immunodeficiency Virus -- immunology KW - Mice, Inbred BALB C KW - Mutagenesis KW - env Gene Products, Human Immunodeficiency Virus -- genetics KW - gag Gene Products, Human Immunodeficiency Virus -- genetics KW - Cells, Cultured KW - HIV Antibodies -- immunology KW - Spleen -- immunology KW - T-Lymphocytes -- immunology KW - Vaccinia virus -- immunology KW - HIV-1 -- immunology KW - AIDS Vaccines -- immunology KW - HIV Infections -- prevention & control KW - AIDS Vaccines -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67648809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Design+and+evaluation+of+multi-gene%2C+multi-clade+HIV-1+MVA+vaccines.&rft.au=Earl%2C+Patricia+L%3BCotter%2C+Catherine%3BMoss%2C+Bernard%3BVanCott%2C+Thomas%3BCurrier%2C+Jeffrey%3BEller%2C+Leigh+Anne%3BMcCutchan%2C+Francine%3BBirx%2C+Deborah+L%3BMichael%2C+Nelson+L%3BMarovich%2C+Mary+A%3BRobb%2C+Merlin%3BCox%2C+Josephine+H&rft.aulast=Earl&rft.aufirst=Patricia&rft.date=2009-09-25&rft.volume=27&rft.issue=42&rft.spage=5885&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2009.07.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-21 N1 - Date created - 2009-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 1993 Mar;193(1):483-91 [8438583] Virology. 1993 Aug;195(2):732-44 [8337842] J Virol. 1994 May;68(5):3015-26 [7512157] J Virol. 1994 Sep;68(9):5411-22 [8057423] Vaccine. 1994 Aug;12(11):1032-40 [7975844] Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):9004-8 [7568061] Science. 1996 May 10;272(5263):872-7 [8629022] J Virol. 2000 Mar;74(6):2740-51 [10684290] J Virol. 2000 May;74(9):4236-43 [10756037] Vaccine. 2000 Jul 15;18(27):3113-22 [10856791] Virology. 2000 Oct 10;276(1):202-13 [11022008] J Virol. 2001 Jan;75(2):645-53 [11134278] Science. 2001 Apr 6;292(5514):69-74 [11393868] J Virol. 2001 Jun;75(11):5151-8 [11333896] Science. 1996 Jun 28;272(5270):1955-8 [8658171] AIDS. 1996 Jun;10(7):793-4 [8805872] Vaccine. 1996 Oct;14(15):1451-8 [8994321] Virology. 1997 Nov 24;238(2):198-211 [9400593] J Gen Virol. 1998 Feb;79 ( Pt 2):347-52 [9472619] Virology. 1998 May 10;244(2):365-96 [9601507] J Gen Virol. 1998 May;79 ( Pt 5):1159-67 [9603331] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7496-501 [10377443] Vaccine. 1999 Oct 14;18(5-6):392-7 [10519927] Nature. 2004 Dec 9;432(7018):769-75 [15592417] J Virol. 2005 Dec;79(24):15547-55 [16306625] Vaccine. 2006 Apr 12;24(16):3332-9 [16472543] J Virol. 2006 May;80(10):4717-28 [16641265] Vaccine. 2006 May 22;24(21):4554-61 [16150517] Blood. 2006 Jun 15;107(12):4781-9 [16467198] J Virol. 2006 Jul;80(13):6318-23 [16775319] J Infect Dis. 2006 Dec 15;194(12):1638-49 [17109335] AIDS. 2006 Nov 28;20(18):2293-303 [17117015] J Gen Virol. 2007 Jan;88(Pt 1):1-12 [17170430] Nat Med. 2007 Jan;13(1):100-6 [17187074] Vaccine. 2007 Mar 1;25(11):2120-7 [17250931] Virology. 2007 Sep 15;366(1):84-97 [17499326] AIDS Res Hum Retroviruses. 2007 Oct;23(10):1283-92 [17961117] AIDS. 2008 Jan 30;22(3):325-31 [18195558] Vaccine. 2008 Jan 24;26(4):486-93 [18155813] Curr Protoc Mol Biol. 2001 May;Chapter 16:Unit16.17 [18265124] J Infect Dis. 2008 Feb 15;197(4):563-71 [18275276] AIDS Res Hum Retroviruses. 2008 Feb;24(2):195-206 [18240957] J Exp Med. 2008 May 12;205(5):1009-17 [18426987] J Virol. 2008 Jul;82(13):6434-46 [18434400] Nature. 2008 Oct 2;455(7213):613-9 [18833271] J Infect Dis. 2008 Nov 15;198(10):1482-90 [18808335] Lancet. 2008 Nov 29;372(9653):1881-93 [19012954] Lancet. 2008 Nov 29;372(9653):1894-905 [19012957] Nature. 2009 Jan 1;457(7225):87-91 [18997770] Nat Med. 2009 Mar;15(3):293-9 [19219024] J Virol. 2009 Jul;83(14):7176-84 [19420086] Vaccine. 2009 Jul 16;27(33):4468-74 [19450644] Vaccine. 2001 Jun 14;19(27):3700-9 [11395204] J Virol. 2002 Jan;76(1):185-94 [11739684] Virology. 2002 Mar 15;294(2):270-81 [12009868] J Virol. 2002 Jun;76(12):6138-46 [12021347] J Virol. 2002 Aug;76(15):7625-31 [12097576] AIDS. 2002 Sep 6;16(13):1809-20 [12218394] AIDS Res Hum Retroviruses. 2002 Nov 20;18(17):1281-90 [12487816] Blood. 2004 Feb 1;103(3):966-72 [12958069] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4590-5 [15070762] AIDS Res Hum Retroviruses. 2004 Aug;20(8):895-901 [15320994] Dtsch Med Wochenschr. 1974 Nov 22;99(47):2386-92 [4426258] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8122-6 [3095828] Nature. 1987 Jun 25-Jul 1;327(6124):716-7 [2439916] J Virol. 1988 Jan;62(1):139-47 [3257102] Proc Natl Acad Sci U S A. 1989 Nov;86(22):8964-7 [2479031] J Virol. 1990 May;64(5):2448-51 [2182912] J Gen Virol. 1991 May;72 ( Pt 5):1031-8 [2033387] J Virol. 1992 Nov;66(11):6547-54 [1404602] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10847-51 [1438287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2009.07.039 ER - TY - JOUR T1 - MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR. AN - 67683865; 19778447 AB - Multiple approaches for the site-directed mutagenesis (SDM) have been developed. However, only several of them are designed for simultaneous introduction of multiple nucleotide alterations, and these are time consuming. In addition, many of the existing multiple SDM methods have technical limitations associated with type and number of mutations that can be introduced, or are technically demanding and require special chemical reagents. In this study we developed a quick and efficient strategy for introduction of multiple complex mutations in a target DNA without intermediate subcloning by using a combination of connecting SDM and suppression PCR. The procedure consists of sequential rounds, with each individual round including PCR amplification of target DNA with two non-overlapping pairs of oligonucleotides. The desired mutation is incorporated at the 5' end of one or both internal oligonucleotides. DNA fragments obtained during amplification are mixed and ligated. The resulting DNA mixture is amplified with external oligonucleotides that act as suppression adapters. Suppression PCR limits amplification to DNA molecules representing full length target DNA, while amplification of other types of molecules formed during ligation is suppressed. To create additional mutations, an aliquot of the ligation mixture is then used directly for the next round of mutagenesis employing internal oligonucleotides specific for another region of target DNA. A wide variety of complex multiple mutations can be generated in a short period of time. The procedure is rapid, highly efficient and does not require special chemical reagents. Thus, MALS represents a powerful alternative to the existing methods for multiple SDM. JF - BMC biotechnology AU - Fushan, Alexey A AU - Drayna, Dennis T AD - National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA. fushana@nidcd.nih.gov Y1 - 2009/09/24/ PY - 2009 DA - 2009 Sep 24 SP - 83 VL - 9 KW - Index Medicus KW - Mutation KW - Mutagenesis, Site-Directed -- methods KW - Polymerase Chain Reaction -- methods KW - Ligase Chain Reaction -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67683865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+biotechnology&rft.atitle=MALS%3A+an+efficient+strategy+for+multiple+site-directed+mutagenesis+employing+a+combination+of+DNA+amplification%2C+ligation+and+suppression+PCR.&rft.au=Fushan%2C+Alexey+A%3BDrayna%2C+Dennis+T&rft.aulast=Fushan&rft.aufirst=Alexey&rft.date=2009-09-24&rft.volume=9&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=BMC+biotechnology&rft.issn=1472-6750&rft_id=info:doi/10.1186%2F1472-6750-9-83 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Mol Biol. 2002;182:37-43 [11768973] Methods Mol Biol. 2002;192:167-74 [12494649] Anal Biochem. 2003 Oct 15;321(2):226-35 [14511688] Anal Biochem. 2004 Jan 15;324(2):285-91 [14690693] Gene. 1993 Apr 15;126(1):35-41 [8472960] Biotechniques. 1993 Jul;15(1):68-70, 72-4, 76 [8363840] Gene. 1993 Nov 30;134(1):83-7 [8244035] Anal Biochem. 1994 Sep;221(2):425-8 [7810892] Nucleic Acids Res. 1995 Mar 25;23(6):1087-8 [7731798] Biotechniques. 1995 Oct;19(4):559-64 [8777044] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6025-30 [8650213] Biotechniques. 1996 Mar;20(3):352-4 [8679185] Nucleic Acids Res. 1996 Sep 15;24(18):3546-51 [8836181] Anal Biochem. 1997 Dec 15;254(2):157-78 [9417773] Genet Anal. 1999 Apr;15(2):51-63 [10191986] Nucleic Acids Res. 1999 Sep 15;27(18):e23 [10471753] J Biotechnol. 2007 Feb 20;128(3):435-43 [17194496] BMC Biotechnol. 2008;8:91 [19055817] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1472-6750-9-83 ER - TY - JOUR T1 - Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis. AN - 67413027; 19549593 AB - The thyroid hormone receptors (TRs) are transcription factors that mediate the pleiotropic activities of the thyroid hormone, T3. Four T3-binding isoforms, TRalpha1, TRbeta1, TRbeta2, and TRbeta3, are encoded by two genes, THRA and THRB. Mutations and altered expression of TRs have been reported in human cancers. A targeted germ-line mutation of the Thrbeta gene in the mouse leads to spontaneous development of follicular thyroid carcinoma (TRbeta(PV/PV) mouse). The TRbetaPV mutant has lost T3-binding activity and displays potent dominant negative activity. The striking phenotype of thyroid cancer exhibited by TRbeta(PV/PV) mice has recently led to the discovery of novel non-genomic actions of TRbetaPV that contribute to thyroid carcinogenesis. These actions involve direct physical interaction of TRbetaPV with cellular proteins, namely the regulatory subunit of the phosphatidylinositol 3-kinase (p85alpha), the pituitary tumor transforming gene (PTTG) and beta-catenin, that are critically involved in cell proliferation, motility, migration, and metastasis. Thus, a TRbeta mutant (TRbetaPV), via a novel mode of non-genomic action, acts as an oncogene in thyroid carcinogenesis. JF - Molecular and cellular endocrinology AU - Guigon, Celine J AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4264, USA. Y1 - 2009/09/24/ PY - 2009 DA - 2009 Sep 24 SP - 63 EP - 69 VL - 308 IS - 1-2 KW - Neoplasm Proteins KW - 0 KW - Receptors, Thyroid Hormone KW - Securin KW - beta Catenin KW - pituitary tumor-transforming protein 1, human KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Oncogenes KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - beta Catenin -- metabolism KW - Neoplasm Proteins -- genetics KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Neoplasm Proteins -- metabolism KW - Mutation KW - Signal Transduction -- physiology KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - Receptors, Thyroid Hormone -- metabolism KW - Receptors, Thyroid Hormone -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67413027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Novel+non-genomic+signaling+of+thyroid+hormone+receptors+in+thyroid+carcinogenesis.&rft.au=Guigon%2C+Celine+J%3BCheng%2C+Sheue-yann&rft.aulast=Guigon&rft.aufirst=Celine&rft.date=2009-09-24&rft.volume=308&rft.issue=1-2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=1872-8057&rft_id=info:doi/10.1016%2Fj.mce.2009.01.007 LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mce.2009.01.007 ER - TY - CPAPER T1 - NCI's Office of Biorespoitories and Biospecimen Research: Advancing the Biospecimen Sciences T2 - World Biobanking Summit AN - 42499853; 5441115 JF - World Biobanking Summit AU - Lim, Mark Y1 - 2009/09/24/ PY - 2009 DA - 2009 Sep 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42499853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=World+Biobanking+Summit&rft.atitle=NCI%27s+Office+of+Biorespoitories+and+Biospecimen+Research%3A+Advancing+the+Biospecimen+Sciences&rft.au=Lim%2C+Mark&rft.aulast=Lim&rft.aufirst=Mark&rft.date=2009-09-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=World+Biobanking+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/BE2009/Posters.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HER2- and EGFR-Specific Affiprobes - A Novel Recombinant Optical Probes for Cell Imaging T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42464865; 5423013 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Lyakhov, I AU - Zielinski, R AU - Kramer-Marek, G AU - Fisher, R AU - Chertov, O AU - Bindu, L AU - Capala, J Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Probes KW - Imaging techniques KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42464865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=HER2-+and+EGFR-Specific+Affiprobes+-+A+Novel+Recombinant+Optical+Probes+for+Cell+Imaging&rft.au=Lyakhov%2C+I%3BZielinski%2C+R%3BKramer-Marek%2C+G%3BFisher%2C+R%3BChertov%2C+O%3BBindu%2C+L%3BCapala%2C+J&rft.aulast=Lyakhov&rft.aufirst=I&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imaging Probe Development Center at the National Institutes of Health: Production of Diverse Nanoparticle-Based Molecular Imaging Probes T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42463098; 5423642 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Xu, B. AU - Wu, H. AU - Sulima, A AU - Wilson, C AU - Shenoy, N AU - Cheal, S AU - Aicher, B AU - Cofiell, S AU - Shi, Z AU - Dulcey, A AU - Vasalatiy, O AU - Smith, V AU - Bhattacharyya, F AU - Hu, Y. AU - Li, C. AU - Barbacow, K AU - Lamb, J AU - Baglino, C AU - Boone, D AU - Griffiths, G Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Probes KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42463098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=The+Imaging+Probe+Development+Center+at+the+National+Institutes+of+Health%3A+Production+of+Diverse+Nanoparticle-Based+Molecular+Imaging+Probes&rft.au=Xu%2C+B.%3BWu%2C+H.%3BSulima%2C+A%3BWilson%2C+C%3BShenoy%2C+N%3BCheal%2C+S%3BAicher%2C+B%3BCofiell%2C+S%3BShi%2C+Z%3BDulcey%2C+A%3BVasalatiy%2C+O%3BSmith%2C+V%3BBhattacharyya%2C+F%3BHu%2C+Y.%3BLi%2C+C.%3BBarbacow%2C+K%3BLamb%2C+J%3BBaglino%2C+C%3BBoone%2C+D%3BGriffiths%2C+G&rft.aulast=Xu&rft.aufirst=B.&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research and Funding Opportunities in Genetic Studies and Molecular Imaging at NIDA T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42462508; 5423208 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Wu, D. AU - Pollock, J Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Imaging techniques KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42462508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Research+and+Funding+Opportunities+in+Genetic+Studies+and+Molecular+Imaging+at+NIDA&rft.au=Wu%2C+D.%3BPollock%2C+J&rft.aulast=Wu&rft.aufirst=D.&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of H-type Dimer Formation in Designing in vivo Activatable Optical Molecular Imaging Probes T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42462410; 5423128 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Ogawa, M AU - Kosaka, N AU - Choyke, P AU - Kobayashi, H Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Probes KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42462410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=The+Role+of+H-type+Dimer+Formation+in+Designing+in+vivo+Activatable+Optical+Molecular+Imaging+Probes&rft.au=Ogawa%2C+M%3BKosaka%2C+N%3BChoyke%2C+P%3BKobayashi%2C+H&rft.aulast=Ogawa&rft.aufirst=M&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging P-glycoprotein Function at the Blood Brain Barrier with 11C-N-Desmethyl-Loperamide T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42460402; 5423145 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Liow, J AU - Zoghbi, S AU - Kreisl, W AU - Lazarova, N AU - Seneca, N AU - Gladding, R AU - Tuan, E AU - Taku, A AU - Herscovitch, P AU - Pike, V AU - Innis, R Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Brain KW - Neuroimaging KW - P-Glycoprotein KW - Blood-brain barrier KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42460402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Imaging+P-glycoprotein+Function+at+the+Blood+Brain+Barrier+with+11C-N-Desmethyl-Loperamide&rft.au=Liow%2C+J%3BZoghbi%2C+S%3BKreisl%2C+W%3BLazarova%2C+N%3BSeneca%2C+N%3BGladding%2C+R%3BTuan%2C+E%3BTaku%2C+A%3BHerscovitch%2C+P%3BPike%2C+V%3BInnis%2C+R&rft.aulast=Liow&rft.aufirst=J&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of metabotropic glutamate subtype 5 receptor with bolus plus constant infusion administration of 18F-SP203 in healthy humans T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42459945; 5423390 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Kimura, Y AU - Zoghbi, S AU - Simeon, F AU - Hatazawa, J AU - Pike, V AU - Innis, R AU - Fujita, M Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Glutamic acid receptors (metabotropic) KW - Glutamic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Quantification+of+metabotropic+glutamate+subtype+5+receptor+with+bolus+plus+constant+infusion+administration+of+18F-SP203+in+healthy+humans&rft.au=Kimura%2C+Y%3BZoghbi%2C+S%3BSimeon%2C+F%3BHatazawa%2C+J%3BPike%2C+V%3BInnis%2C+R%3BFujita%2C+M&rft.aulast=Kimura&rft.aufirst=Y&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo Real-Time, Multicolor, Optical Lymphatic Imaging Using Quantum-dots T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42459766; 5423338 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Kosaka, N AU - Ogawa, M AU - Sato, N AU - Choyke, P AU - Kobayashi, H Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=In+vivo+Real-Time%2C+Multicolor%2C+Optical+Lymphatic+Imaging+Using+Quantum-dots&rft.au=Kosaka%2C+N%3BOgawa%2C+M%3BSato%2C+N%3BChoyke%2C+P%3BKobayashi%2C+H&rft.aulast=Kosaka&rft.aufirst=N&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulsed High Intensity Focused Ultrasound Exposures Enhanced Delivery: Investigations in a Murine Model T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42459528; 5423289 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Hancock, H AU - Smith, L AU - Frenkel, V Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Animal models KW - Ultrasound KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Pulsed+High+Intensity+Focused+Ultrasound+Exposures+Enhanced+Delivery%3A+Investigations+in+a+Murine+Model&rft.au=Hancock%2C+H%3BSmith%2C+L%3BFrenkel%2C+V&rft.aulast=Hancock&rft.aufirst=H&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Motion Tracking Using Optical Navigation During In-Vivo Two-Photon Microscopy T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42459351; 5423099 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Schroeder, J AU - Luger-Hamer, M AU - Pursley, R AU - Kellman, P AU - Balaban, R Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Navigation KW - Microscopy KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Motion+Tracking+Using+Optical+Navigation+During+In-Vivo+Two-Photon+Microscopy&rft.au=Schroeder%2C+J%3BLuger-Hamer%2C+M%3BPursley%2C+R%3BKellman%2C+P%3BBalaban%2C+R&rft.aulast=Schroeder&rft.aufirst=J&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of cAMP Dependent Protein Kinase Activator and Inhibitor on In Vivo Rolipram Binding to Phosphodiesterase 4 in Conscious Rats T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42459098; 5423163 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Itoh, T AU - Abe, K AU - Hong, J AU - Inoue, O AU - Pike, V AU - Innis, R AU - Fujita, M Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Rats KW - Phosphodiesterase IV KW - Protein kinase KW - Cyclic AMP KW - Rolipram KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42459098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Effects+of+cAMP+Dependent+Protein+Kinase+Activator+and+Inhibitor+on+In+Vivo+Rolipram+Binding+to+Phosphodiesterase+4+in+Conscious+Rats&rft.au=Itoh%2C+T%3BAbe%2C+K%3BHong%2C+J%3BInoue%2C+O%3BPike%2C+V%3BInnis%2C+R%3BFujita%2C+M&rft.aulast=Itoh&rft.aufirst=T&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescence Lifetime Imaging of Activatable Target Specific Molecular Probes T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42458741; 5423054 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Alford, R AU - Ogawa, M AU - Hassan, M AU - Gandjbakhche, A AU - Choyke, P AU - Kobayashi, H Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Fluorescence KW - Fluorescent indicators KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42458741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Fluorescence+Lifetime+Imaging+of+Activatable+Target+Specific+Molecular+Probes&rft.au=Alford%2C+R%3BOgawa%2C+M%3BHassan%2C+M%3BGandjbakhche%2C+A%3BChoyke%2C+P%3BKobayashi%2C+H&rft.aulast=Alford&rft.aufirst=R&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Multicolor Tumor-specific Painting Using Dehalogenase-based Protein-tag (Halo-Tag) Fluorescent Ligands T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42458064; 5423494 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Kobayashi, H AU - Kosaka, N AU - Ogawa, M AU - Karassina, N AU - Corona, C AU - McDougall, M AU - Hoyt, C AU - Levenson, R AU - Los, G AU - Choyke, P Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42458064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=In+Vivo+Multicolor+Tumor-specific+Painting+Using+Dehalogenase-based+Protein-tag+%28Halo-Tag%29+Fluorescent+Ligands&rft.au=Kobayashi%2C+H%3BKosaka%2C+N%3BOgawa%2C+M%3BKarassina%2C+N%3BCorona%2C+C%3BMcDougall%2C+M%3BHoyt%2C+C%3BLevenson%2C+R%3BLos%2C+G%3BChoyke%2C+P&rft.aulast=Kobayashi&rft.aufirst=H&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monitoring of potential growth in mice of human neuroblastoma tumor-initiating cells by MRI at 1.5T T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42458040; 5422856 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Baio, G AU - Corrias, M AU - Gambini, C AU - Cilli, M AU - Taverniti, G AU - Neumaier, C Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Mice KW - Magnetic resonance imaging KW - Neuroblastoma KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42458040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Monitoring+of+potential+growth+in+mice+of+human+neuroblastoma+tumor-initiating+cells+by+MRI+at+1.5T&rft.au=Baio%2C+G%3BCorrias%2C+M%3BGambini%2C+C%3BCilli%2C+M%3BTaverniti%2C+G%3BNeumaier%2C+C&rft.aulast=Baio&rft.aufirst=G&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Image-able Temperature Sensitive Liposomes for Image-guided Drug Delivery with MR-guided High Intensity Focused Ultrasound T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42457909; 5423468 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Negussie, A AU - Yarmolenko, P AU - Bryant, H AU - Partanen, A AU - Dewhirst, M AU - Dreher, M AU - Wood, B Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Temperature effects KW - Drug delivery KW - Liposomes KW - Ultrasound KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42457909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Image-able+Temperature+Sensitive+Liposomes+for+Image-guided+Drug+Delivery+with+MR-guided+High+Intensity+Focused+Ultrasound&rft.au=Negussie%2C+A%3BYarmolenko%2C+P%3BBryant%2C+H%3BPartanen%2C+A%3BDewhirst%2C+M%3BDreher%2C+M%3BWood%2C+B&rft.aulast=Negussie&rft.aufirst=A&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validation of Targeted Localization of Adenomatous Colon Polyps in ApcMin/+ Mice by microCT Colonography, OCT and Multispectral Optical Imaging T2 - 2009 World Molecular Imaging Congress (WMIC 2009) AN - 42457415; 5423645 JF - 2009 World Molecular Imaging Congress (WMIC 2009) AU - Roney, C AU - Xu, B. AU - Yuan, S AU - Chen, Y AU - Xie, J AU - Griffiths, G AU - Summers, R Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Mice KW - Polyps KW - Colon KW - Imaging techniques KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42457415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.atitle=Validation+of+Targeted+Localization+of+Adenomatous+Colon+Polyps+in+ApcMin%2F%2B+Mice+by+microCT+Colonography%2C+OCT+and+Multispectral+Optical+Imaging&rft.au=Roney%2C+C%3BXu%2C+B.%3BYuan%2C+S%3BChen%2C+Y%3BXie%2C+J%3BGriffiths%2C+G%3BSummers%2C+R&rft.aulast=Roney&rft.aufirst=C&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Molecular+Imaging+Congress+%28WMIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://wmicmeeting.abstractcentral.com/itin.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Dimensions in Cell Migration and Matrix Interactions T2 - 2009 Journal of Cell Biology Young Investigators Meeting , Cell Biology of Disease: Chromosomes, Cancer and Stem Cells AN - 42449103; 5418956 JF - 2009 Journal of Cell Biology Young Investigators Meeting , Cell Biology of Disease: Chromosomes, Cancer and Stem Cells AU - Yamada, Kenneth Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 KW - Migration KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42449103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Journal+of+Cell+Biology+Young+Investigators+Meeting+%2C+Cell+Biology+of+Disease%3A+Chromosomes%2C+Cancer+and+Stem+Cells&rft.atitle=New+Dimensions+in+Cell+Migration+and+Matrix+Interactions&rft.au=Yamada%2C+Kenneth&rft.aulast=Yamada&rft.aufirst=Kenneth&rft.date=2009-09-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Journal+of+Cell+Biology+Young+Investigators+Meeting+%2C+Cell+Biology+of+Disease%3A+Chromosomes%2C+Cancer+and+Stem+Cells&rft.issn=&rft_id=info:doi/ L2 - http://www.nyas.org/asset.axd?id=f4cd3985-73da-4f12-8f08-c8bc632c64f5& t=633840309224100000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Progenitors Generated in an Inflammatory Microenvironment Are Functionally Incorporated into the Injured Mouse Hippocampus. T2 - 2009 World Stem Cell Summit AN - 42499609; 5441346 JF - 2009 World Stem Cell Summit AU - McPherson,, Christopher AU - Harry, G Y1 - 2009/09/21/ PY - 2009 DA - 2009 Sep 21 KW - Microenvironments KW - Inflammation KW - Hippocampus KW - Neural stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42499609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Stem+Cell+Summit&rft.atitle=Neural+Progenitors+Generated+in+an+Inflammatory+Microenvironment+Are+Functionally+Incorporated+into+the+Injured+Mouse+Hippocampus.&rft.au=McPherson%2C%2C+Christopher%3BHarry%2C+G&rft.aulast=McPherson&rft.aufirst=&rft.date=2009-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Stem+Cell+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.worldstemcellsummit.com/2009_abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Directed Differentiation of Human Embryonic Stem Cells into Thyroid-Like Cells: a Novel Approach to Study Sodium-Iodine Symporter for Low Differentiated Thyroid Cancer Treatment T2 - 2009 World Stem Cell Summit AN - 42497368; 5441243 JF - 2009 World Stem Cell Summit AU - Onyshchenko, Mykola AU - Neumann, Ronald AU - Panyutin, Igor Y1 - 2009/09/21/ PY - 2009 DA - 2009 Sep 21 KW - Cancer KW - Stem cells KW - Thyroid KW - Differentiation KW - Embryo cells KW - Thyroid cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42497368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Stem+Cell+Summit&rft.atitle=Directed+Differentiation+of+Human+Embryonic+Stem+Cells+into+Thyroid-Like+Cells%3A+a+Novel+Approach+to+Study+Sodium-Iodine+Symporter+for+Low+Differentiated+Thyroid+Cancer+Treatment&rft.au=Onyshchenko%2C+Mykola%3BNeumann%2C+Ronald%3BPanyutin%2C+Igor&rft.aulast=Onyshchenko&rft.aufirst=Mykola&rft.date=2009-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Stem+Cell+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.worldstemcellsummit.com/2009_abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Lung Cancer Stem Cells Self-renew and Maintain the Tumor Bulk through Asymmetric Cell Division T2 - 2009 World Stem Cell Summit AN - 42495479; 5441231 JF - 2009 World Stem Cell Summit AU - Pine, Sharon AU - Ryan, Brid AU - Harris, Curtis Y1 - 2009/09/21/ PY - 2009 DA - 2009 Sep 21 KW - Stem cells KW - Tumors KW - Lung cancer KW - Cell division KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42495479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Stem+Cell+Summit&rft.atitle=Human+Lung+Cancer+Stem+Cells+Self-renew+and+Maintain+the+Tumor+Bulk+through+Asymmetric+Cell+Division&rft.au=Pine%2C+Sharon%3BRyan%2C+Brid%3BHarris%2C+Curtis&rft.aulast=Pine&rft.aufirst=Sharon&rft.date=2009-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Stem+Cell+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.worldstemcellsummit.com/2009_abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Ionizing Radiation on Pluripotency of Human Embryonic Stem Cells T2 - 2009 World Stem Cell Summit AN - 42492845; 5441241 JF - 2009 World Stem Cell Summit AU - Sokolov, M AU - Onyshchenko, M AU - Panyutin, I AU - Neumann, R Y1 - 2009/09/21/ PY - 2009 DA - 2009 Sep 21 KW - Stem cells KW - Ionizing radiation KW - Embryo cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42492845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+World+Stem+Cell+Summit&rft.atitle=Effect+of+Ionizing+Radiation+on+Pluripotency+of+Human+Embryonic+Stem+Cells&rft.au=Sokolov%2C+M%3BOnyshchenko%2C+M%3BPanyutin%2C+I%3BNeumann%2C+R&rft.aulast=Sokolov&rft.aufirst=M&rft.date=2009-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+World+Stem+Cell+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.worldstemcellsummit.com/2009_abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Homozygous Deletion of pdlim2 Is Associated with Structure Abnormality of Corneal Epithelia and Dramatic Changes in Expression of Cytoskeletal Proteins T2 - 2009 American Society for Cell Biology (ASCB)/Japan Society for Cell Biology (JSCB)/RIKEN Center for Developmental Biology (RIKEN CDB) Meeting on "Building the Body Plan: How Cell Adhesion, Signaling and Cytoskeletal Regulation Shape Morhphogenesis" AN - 42378553; 5380623 JF - 2009 American Society for Cell Biology (ASCB)/Japan Society for Cell Biology (JSCB)/RIKEN Center for Developmental Biology (RIKEN CDB) Meeting on "Building the Body Plan: How Cell Adhesion, Signaling and Cytoskeletal Regulation Shape Morhphogenesis" AU - Gao, C AU - Saravanamuthu, S AU - Tomarev, S AU - Grusby, M AU - Zelenka, P Y1 - 2009/09/21/ PY - 2009 DA - 2009 Sep 21 KW - Cytoskeleton KW - Gene deletion KW - Cornea KW - Epithelia KW - Abnormalities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42378553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Society+for+Cell+Biology+%28ASCB%29%2FJapan+Society+for+Cell+Biology+%28JSCB%29%2FRIKEN+Center+for+Developmental+Biology+%28RIKEN+CDB%29+Meeting+on+%22Building+the+Body+Plan%3A+How+Cell+Adhesion%2C+Signaling+and+Cytoskeletal+Regulation+Shape+Morhphogenesis%22&rft.atitle=Homozygous+Deletion+of+pdlim2+Is+Associated+with+Structure+Abnormality+of+Corneal+Epithelia+and+Dramatic+Changes+in+Expression+of+Cytoskeletal+Proteins&rft.au=Gao%2C+C%3BSaravanamuthu%2C+S%3BTomarev%2C+S%3BGrusby%2C+M%3BZelenka%2C+P&rft.aulast=Gao&rft.aufirst=C&rft.date=2009-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Society+for+Cell+Biology+%28ASCB%29%2FJapan+Society+for+Cell+Biology+%28JSCB%29%2FRIKEN+Center+for+Developmental+Biology+%28RIKEN+CDB%29+Meeting+on+%22Building+the+Body+Plan%3A+How+Cell+Adhesion%2C+Signaling+and+Cytoskeletal+Regulation+Shape+Morhphogenesis%22&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/Japan2009/documents/Summer_Program_updated.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunohistochemical evaluation of PI3K/p-Akt pathways alterations in combination with conventional biomarkers in early stage breast cancer patients treated with cyclophosphamide/metotrexate/5-fluorouracil based chemotherapy: identification of an Unfavorable Biologic Profile T2 - 15th European Cancer Conference (ECCO 15) AN - 42440952; 5407271 JF - 15th European Cancer Conference (ECCO 15) AU - Novelli, F AU - Bria, E AU - Di Benedetto, A AU - Melucci, E AU - Sperduti, I AU - Vici, P AU - Nistico, C AU - Pinnaro, P AU - Fabi, A AU - Mottolese, M Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Chemotherapy KW - Bioindicators KW - Breast cancer KW - 5-Fluorouracil KW - Cyclophosphamide KW - 1-Phosphatidylinositol 3-kinase KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42440952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Immunohistochemical+evaluation+of+PI3K%2Fp-Akt+pathways+alterations+in+combination+with+conventional+biomarkers+in+early+stage+breast+cancer+patients+treated+with+cyclophosphamide%2Fmetotrexate%2F5-fluorouracil+based+chemotherapy%3A+identification+of+an+Unfavorable+Biologic+Profile&rft.au=Novelli%2C+F%3BBria%2C+E%3BDi+Benedetto%2C+A%3BMelucci%2C+E%3BSperduti%2C+I%3BVici%2C+P%3BNistico%2C+C%3BPinnaro%2C+P%3BFabi%2C+A%3BMottolese%2C+M&rft.aulast=Novelli&rft.aufirst=F&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - eNOS plays a critical role in the tumor initiation and progression in chronically stressed mice T2 - 15th European Cancer Conference (ECCO 15) AN - 42437683; 5407490 JF - 15th European Cancer Conference (ECCO 15) AU - Barbieri, A AU - Palma, G AU - Rosati, A AU - Turco, M c AU - Petrillo, A AU - Vecchione, M AU - Di Bernardo, M AU - Giudice, A AU - Arra, C AU - Iaffaioli, Mv Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Mice KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42437683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=eNOS+plays+a+critical+role+in+the+tumor+initiation+and+progression+in+chronically+stressed+mice&rft.au=Barbieri%2C+A%3BPalma%2C+G%3BRosati%2C+A%3BTurco%2C+M+c%3BPetrillo%2C+A%3BVecchione%2C+M%3BDi+Bernardo%2C+M%3BGiudice%2C+A%3BArra%2C+C%3BIaffaioli%2C+Mv&rft.aulast=Barbieri&rft.aufirst=A&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New dendritic cell immunotherapy approach: randomized phase II study in IIB-IIIA stage non-small cell lung cancer patients T2 - 15th European Cancer Conference (ECCO 15) AN - 42436718; 5407633 JF - 15th European Cancer Conference (ECCO 15) AU - Sovenko, V AU - Khranovska, N AU - Ganul, V AU - Shvets, Y AU - Ganul, A AU - Sitko, V AU - Skachkova, O AU - Zemskov, S AU - Grinevich, Y Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Immunotherapy KW - Lung cancer KW - Non-small cell lung carcinoma KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42436718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=New+dendritic+cell+immunotherapy+approach%3A+randomized+phase+II+study+in+IIB-IIIA+stage+non-small+cell+lung+cancer+patients&rft.au=Sovenko%2C+V%3BKhranovska%2C+N%3BGanul%2C+V%3BShvets%2C+Y%3BGanul%2C+A%3BSitko%2C+V%3BSkachkova%2C+O%3BZemskov%2C+S%3BGrinevich%2C+Y&rft.aulast=Sovenko&rft.aufirst=V&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single vs double dose palonosetron for the prevention of acute and delayed nausea and vomiting in patients undergoing high dose chemotherapy and autologous stem cell transplantation T2 - 15th European Cancer Conference (ECCO 15) AN - 42436629; 5407267 JF - 15th European Cancer Conference (ECCO 15) AU - Marcacci, G AU - Becchimanzi, C AU - Arcamone, M AU - Capobianco, G AU - Corazzelli, G AU - Frigeri, F AU - Russo, F AU - Pinto, A Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Chemotherapy KW - Stem cells KW - Prevention KW - Autografts KW - Stem cell transplantation KW - Nausea KW - Vomiting KW - Transplantation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42436629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Single+vs+double+dose+palonosetron+for+the+prevention+of+acute+and+delayed+nausea+and+vomiting+in+patients+undergoing+high+dose+chemotherapy+and+autologous+stem+cell+transplantation&rft.au=Marcacci%2C+G%3BBecchimanzi%2C+C%3BArcamone%2C+M%3BCapobianco%2C+G%3BCorazzelli%2C+G%3BFrigeri%2C+F%3BRusso%2C+F%3BPinto%2C+A&rft.aulast=Marcacci&rft.aufirst=G&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survival and clinicopathologic characteristics of invasive adenocarcinoma of the uterine cervix T2 - 15th European Cancer Conference (ECCO 15) AN - 42436412; 5407517 JF - 15th European Cancer Conference (ECCO 15) AU - Melo, A AU - Ferreira, C AU - Mora, P Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Survival KW - Cervix KW - Uterus KW - Adenocarcinoma KW - Invasiveness KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42436412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Survival+and+clinicopathologic+characteristics+of+invasive+adenocarcinoma+of+the+uterine+cervix&rft.au=Melo%2C+A%3BFerreira%2C+C%3BMora%2C+P&rft.aulast=Melo&rft.aufirst=A&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Erlotinib (E) combined with fixed dose-rate gemcitabine (FDR-Gem) as first-line treatment for advanced adenocarcinoma of the pancreas (PDAC): preliminary results from a multicenter phase II study T2 - 15th European Cancer Conference (ECCO 15) AN - 42433287; 5408149 JF - 15th European Cancer Conference (ECCO 15) AU - Milella, M AU - Sperduti, I AU - Gelibter, A AU - Bria, E AU - Cianci, G AU - Moscetti, L AU - Mansueto, G AU - Ruggeri, E AU - Gamucci, T AU - Cognetti, F Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Adenocarcinoma KW - Pancreas KW - Gemcitabine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42433287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Erlotinib+%28E%29+combined+with+fixed+dose-rate+gemcitabine+%28FDR-Gem%29+as+first-line+treatment+for+advanced+adenocarcinoma+of+the+pancreas+%28PDAC%29%3A+preliminary+results+from+a+multicenter+phase+II+study&rft.au=Milella%2C+M%3BSperduti%2C+I%3BGelibter%2C+A%3BBria%2C+E%3BCianci%2C+G%3BMoscetti%2C+L%3BMansueto%2C+G%3BRuggeri%2C+E%3BGamucci%2C+T%3BCognetti%2C+F&rft.aulast=Milella&rft.aufirst=M&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Mena (hMena) and isoforms hMena+11a and hMenadeltaV6, estrogen receptor-beta (ER-B), epidermal growth factor receptor -1 and -2 (EGFR/HER-2) expression as prognostic factors in node-negative Non-Small-Cell Lung Cancer (NSCLC) T2 - 15th European Cancer Conference (ECCO 15) AN - 42433155; 5407606 JF - 15th European Cancer Conference (ECCO 15) AU - Bria, E AU - Mottolese, M AU - Sperduti, I AU - Visca, P AU - Antoniani, B AU - Facciolo, F AU - Di Modugno, F AU - Cognetti, F AU - Nistico, P AU - Milella, M Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Lung cancer KW - Estrogen receptors KW - Growth factors KW - Epidermal growth factor receptors KW - ErbB-2 protein KW - Sex hormones KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42433155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Human+Mena+%28hMena%29+and+isoforms+hMena%2B11a+and+hMenadeltaV6%2C+estrogen+receptor-beta+%28ER-B%29%2C+epidermal+growth+factor+receptor+-1+and+-2+%28EGFR%2FHER-2%29+expression+as+prognostic+factors+in+node-negative+Non-Small-Cell+Lung+Cancer+%28NSCLC%29&rft.au=Bria%2C+E%3BMottolese%2C+M%3BSperduti%2C+I%3BVisca%2C+P%3BAntoniani%2C+B%3BFacciolo%2C+F%3BDi+Modugno%2C+F%3BCognetti%2C+F%3BNistico%2C+P%3BMilella%2C+M&rft.aulast=Bria&rft.aufirst=E&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Zoledronic acid and Taxotere (ZANTE) metronomic and sequential administration in patients with hormone refractory prostate cancer (HRPC) - final results of phase I study T2 - 15th European Cancer Conference (ECCO 15) AN - 42432689; 5407001 JF - 15th European Cancer Conference (ECCO 15) AU - Caraglia, M AU - Morabito, A AU - Marra, M AU - Bochicchio, A AU - Piccirillo, M AU - Franco, R AU - Perrone, F AU - Budillon, A AU - Iaffaioli, R AU - Facchini, G Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Prostate cancer KW - Hormones KW - Zoledronic acid KW - Taxotere KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42432689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Zoledronic+acid+and+Taxotere+%28ZANTE%29+metronomic+and+sequential+administration+in+patients+with+hormone+refractory+prostate+cancer+%28HRPC%29+-+final+results+of+phase+I+study&rft.au=Caraglia%2C+M%3BMorabito%2C+A%3BMarra%2C+M%3BBochicchio%2C+A%3BPiccirillo%2C+M%3BFranco%2C+R%3BPerrone%2C+F%3BBudillon%2C+A%3BIaffaioli%2C+R%3BFacchini%2C+G&rft.aulast=Caraglia&rft.aufirst=M&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA ploidy and proliferative activity in common round cell tumors in children and their value as prognostic indicators T2 - 15th European Cancer Conference (ECCO 15) AN - 42431480; 5408223 JF - 15th European Cancer Conference (ECCO 15) AU - Raafat, A AU - Mahmoud, S AU - El Gerzawi, S. AU - El Serafi, M Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Children KW - Tumors KW - Ploidy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42431480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=DNA+ploidy+and+proliferative+activity+in+common+round+cell+tumors+in+children+and+their+value+as+prognostic+indicators&rft.au=Raafat%2C+A%3BMahmoud%2C+S%3BEl+Gerzawi%2C+S.%3BEl+Serafi%2C+M&rft.aulast=Raafat&rft.aufirst=A&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Balancing pros and cons of the addition of Bevacizumab (BEVA) to first-line chemotherapy (CT) for advanced/metastatic colorectal cancer (MCRC): Meta-analysis of randomized clinical trials exploring absolute benefits T2 - 15th European Cancer Conference (ECCO 15) AN - 42431081; 5407829 JF - 15th European Cancer Conference (ECCO 15) AU - Cuppone, F AU - Vaccaro, V AU - Loupakis, F AU - Milella, M AU - Carlini, P AU - Nistico, C AU - Falcone, A AU - Giannarelli, D AU - Cognetti, F AU - Bria, E Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Chemotherapy KW - Clinical trials KW - Colorectal carcinoma KW - Colorectal cancer KW - Reviews KW - Bevacizumab KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42431081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Balancing+pros+and+cons+of+the+addition+of+Bevacizumab+%28BEVA%29+to+first-line+chemotherapy+%28CT%29+for+advanced%2Fmetastatic+colorectal+cancer+%28MCRC%29%3A+Meta-analysis+of+randomized+clinical+trials+exploring+absolute+benefits&rft.au=Cuppone%2C+F%3BVaccaro%2C+V%3BLoupakis%2C+F%3BMilella%2C+M%3BCarlini%2C+P%3BNistico%2C+C%3BFalcone%2C+A%3BGiannarelli%2C+D%3BCognetti%2C+F%3BBria%2C+E&rft.aulast=Cuppone&rft.aufirst=F&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circulating endothelial cells (CECs) and FDG-PET for early prediction of response in high- risk locally advanced rectal cancer (HR-LARC) patients (pts) treated with two different schedules of bevacizumab (BEV) in combination with preoperative chemo-radiotherapy (CT-RT) T2 - 15th European Cancer Conference (ECCO 15) AN - 42429868; 5407895 JF - 15th European Cancer Conference (ECCO 15) AU - Avallone, A AU - Delrio, P AU - Di Gennaro, E AU - Pecori, B AU - Caraco, C AU - Tatangelo, F AU - Sandomenico, C AU - Petrillo, A AU - Budillon, A AU - Comella, P Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Cancer KW - Bevacizumab KW - Endothelial cells KW - Rectum KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42429868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Circulating+endothelial+cells+%28CECs%29+and+FDG-PET+for+early+prediction+of+response+in+high-+risk+locally+advanced+rectal+cancer+%28HR-LARC%29+patients+%28pts%29+treated+with+two+different+schedules+of+bevacizumab+%28BEV%29+in+combination+with+preoperative+chemo-radiotherapy+%28CT-RT%29&rft.au=Avallone%2C+A%3BDelrio%2C+P%3BDi+Gennaro%2C+E%3BPecori%2C+B%3BCaraco%2C+C%3BTatangelo%2C+F%3BSandomenico%2C+C%3BPetrillo%2C+A%3BBudillon%2C+A%3BComella%2C+P&rft.aulast=Avallone&rft.aufirst=A&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects on quality of life (QoL) of docetaxel-based weekly chemotherapy in patients with locally advanced (LABC) or metastatic breast cancer (MBC): results of a single-centre randomized phase 3 trial T2 - 15th European Cancer Conference (ECCO 15) AN - 42429278; 5407916 JF - 15th European Cancer Conference (ECCO 15) AU - Nuzzo, F AU - Di Rella, F AU - Morabito, A AU - Gravina, A AU - Labonia, V AU - Landi, G AU - Pacilio, C AU - Piccirillo, M AU - Di Maio, M AU - de Matteis, A Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Chemotherapy KW - Quality of life KW - Breast cancer KW - Clinical trials KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42429278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Effects+on+quality+of+life+%28QoL%29+of+docetaxel-based+weekly+chemotherapy+in+patients+with+locally+advanced+%28LABC%29+or+metastatic+breast+cancer+%28MBC%29%3A+results+of+a+single-centre+randomized+phase+3+trial&rft.au=Nuzzo%2C+F%3BDi+Rella%2C+F%3BMorabito%2C+A%3BGravina%2C+A%3BLabonia%2C+V%3BLandi%2C+G%3BPacilio%2C+C%3BPiccirillo%2C+M%3BDi+Maio%2C+M%3Bde+Matteis%2C+A&rft.aulast=Nuzzo&rft.aufirst=F&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fusion genes PAX3/7-FKHR as molecular markers of bone marrow micrometastasis in paediatric alveolar rhabdomyosarcoma T2 - 15th European Cancer Conference (ECCO 15) AN - 42428980; 5408218 JF - 15th European Cancer Conference (ECCO 15) AU - Khranovska, N AU - Klymnyuk, G AU - Shaida, O AU - Svergun, N Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Bone marrow KW - Pediatrics KW - Rhabdomyosarcoma KW - Bone (alveolar) KW - Pax3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42428980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Fusion+genes+PAX3%2F7-FKHR+as+molecular+markers+of+bone+marrow+micrometastasis+in+paediatric+alveolar+rhabdomyosarcoma&rft.au=Khranovska%2C+N%3BKlymnyuk%2C+G%3BShaida%2C+O%3BSvergun%2C+N&rft.aulast=Khranovska&rft.aufirst=N&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Creating an oncology nurse cooperative research group: the GIRC experience T2 - 15th European Cancer Conference (ECCO 15) AN - 42424811; 5406815 JF - 15th European Cancer Conference (ECCO 15) AU - Bryce, J AU - Catania, G AU - Falanga, M AU - Callegaro, L AU - Liptrott, S AU - Feroce, I AU - Colussi, A AU - Grosso, D AU - Connola, M Y1 - 2009/09/20/ PY - 2009 DA - 2009 Sep 20 KW - Nursing KW - Medical personnel KW - Cooperatives KW - Oncology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42424811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+European+Cancer+Conference+%28ECCO+15%29&rft.atitle=Creating+an+oncology+nurse+cooperative+research+group%3A+the+GIRC+experience&rft.au=Bryce%2C+J%3BCatania%2C+G%3BFalanga%2C+M%3BCallegaro%2C+L%3BLiptrott%2C+S%3BFeroce%2C+I%3BColussi%2C+A%3BGrosso%2C+D%3BConnola%2C+M&rft.aulast=Bryce&rft.aufirst=J&rft.date=2009-09-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+European+Cancer+Conference+%28ECCO+15%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ecco-org.eu/Conferences-and-Events/ECCO-15-ESMO-34/Scientif ic-Programme/Searchable-programme/page.aspx/1698 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. AN - 734061065; 19765277 AB - The novel breast cancer metastasis modulator gene signal-induced proliferation-associated 1 (Sipa1) underlies the breast cancer metastasis efficiency modifier locus Mtes 1 and has been shown to influence mammary tumour metastatic efficiency in the mouse, with an ectopically expressing Sipa1 cell line developing 1.5 to 2 fold more surface pulmonary metastases. Sipa1 encodes a mitogen-inducible GTPase activating (GAP) protein for members of the Ras-related proteins; participates in cell adhesion and modulates mitogen-induced cell cycle progression. Germline SIPA1 SNPs showed association with positive lymph node metastasis and hormonal receptor status in a Caucasian cohort. We hypothesized that SIPA1 may also be correlated to breast carcinoma incidence as well as prognosis. Therefore, this study investigated the potential relationship of SIPA1 and human breast cancer incidence by a germline SNP genotype frequency association study in a case-control Caucasian cohort in Queensland, Australia. The SNPs genotyped in this study were identified in a previous study and the genotyping assays were carried out using TaqMan SNP Genotyping Assays. The data were analysed with chi-square method and the Monte Carlo style CLUMP analysis program. Results indicated significance with SIPA1 SNP rs3741378; the CC genotype was more frequently observed in the breast cancer group compared to the disease-free control group, indicating the variant C allele was associated with increased breast cancer incidence. This observation indicates SNP rs3741378 as a novel potential sporadic breast cancer predisposition SNP. While it showed association with hormonal receptor status in breast cancer group in a previous pilot study, this exonic missense SNP (Ser (S) to Phe (F)) changes a hydrophilic residue (S) to a hydrophobic residue (F) and may significantly alter the protein functions of SIPA1 in breast tumourgenesis. SIPA1 SNPs rs931127 (5' near gene), and rs746429 (synonymous (Ala (A) to Ala (A)), did not show significant associations with breast cancer incidence, yet were associated with lymph node metastasis in the previous study. This suggests that SIPA1 may be involved in different stages of breast carcinogenesis and since this study replicates a previous study of the associated SNP, it implicates variants of the SIPA1 gene as playing a potential role in breast cancer. JF - BMC cancer AU - Hsieh, Szu-Min AU - Smith, Robert A AU - Lintell, Nicholas A AU - Hunter, Kent W AU - Griffiths, Lyn R AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. hsiehsz@mail.nih.gov Y1 - 2009/09/18/ PY - 2009 DA - 2009 Sep 18 SP - 331 VL - 9 KW - GTPase-Activating Proteins KW - 0 KW - Nuclear Proteins KW - SIPA1 protein, human KW - Index Medicus KW - Genotype KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Female KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - GTPase-Activating Proteins -- genetics KW - Nuclear Proteins -- genetics KW - Breast Neoplasms -- pathology KW - Polymorphism, Genetic KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734061065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Polymorphisms+of+the+SIPA1+gene+and+sporadic+breast+cancer+susceptibility.&rft.au=Hsieh%2C+Szu-Min%3BSmith%2C+Robert+A%3BLintell%2C+Nicholas+A%3BHunter%2C+Kent+W%3BGriffiths%2C+Lyn+R&rft.aulast=Hsieh&rft.aufirst=Szu-Min&rft.date=2009-09-18&rft.volume=9&rft.issue=&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-9-331 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-02 N1 - Date created - 2009-09-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Dec 10;83(6):723-6 [10597185] Mol Cell Biol. 1995 Jan;15(1):552-60 [7799964] Ann Hum Genet. 1995 Jan;59(Pt 1):97-105 [7762987] Int J Cancer. 2009 Apr 1;124(7):1716-20 [19089925] Nat Genet. 2005 Oct;37(10):1055-62 [16142231] Breast Cancer Res. 2006;8(2):R16 [16563182] J Biol Chem. 1997 Oct 31;272(44):28081-8 [9346962] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2407-9-331 ER - TY - JOUR T1 - Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates. AN - 67614911; 19646406 AB - Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory tract illness worldwide. Presently, the most promising vaccine candidate is a live, attenuated, cDNA-derived virus, RSV rA2cp248/404/1030DeltaSH, whose attenuation phenotype is based in large part on a series of point mutations including a glutamine to leucine (Q to L) substitution at amino acid residue 831 of the polymerase protein L, a mutation originally called "248". This mutation specifies both a temperature sensitive (ts) and attenuation phenotype. Reversion of this mutation from leucine back to glutamine was detected in some samples in clinical phase 1 trials. To identify the most genetically stable "attenuating" codon at this position to be included in a more stable RSV vaccine, we sought to create and evaluate recombinant RSVs representing all 20 possible amino acid assignments at this position, as well as small insertions and deletions. The recoverable viruses constituted a panel representing 18 different amino acid assignments, and were evaluated for temperature sensitivity in vitro and attenuation in mice. The original leucine mutation was found to be the most attenuating, followed only by phenylalanine. The paucity of highly attenuating assignments limited the possibility of increasing genetic stability. Indeed, it was not possible to find a leucine or phenylalanine codon requiring more than a single nucleotide change to yield a "non-attenuating" codon, as is necessary for the stabilization strategy. Nonetheless, serial passage of the six possible leucine codons in vitro at increasing temperatures revealed differences, with slower reversion to non-attenuated phenotypes for a subset of codons. Thus, it should be possible to modestly increase the phenotypic stability of the rA2cp248/404/1030DeltaSH vaccine virus by codon modification at the locus of the 248 mutation. In addition to characterizing the phenotypes associated with a particular locus in the RSV L protein, this manuscript provides insight into the problem of the instability of point mutations and the limitations of strategies to stabilize them. JF - Vaccine AU - Luongo, Cindy AU - Yang, Lijuan AU - Winter, Christine C AU - Spann, Kirsten M AU - Murphy, Brian R AU - Collins, Peter L AU - Buchholz, Ursula J AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-8007, USA. Y1 - 2009/09/18/ PY - 2009 DA - 2009 Sep 18 SP - 5667 EP - 5676 VL - 27 IS - 41 KW - Codon KW - 0 KW - Mutant Proteins KW - Respiratory Syncytial Virus Vaccines KW - Vaccines, Attenuated KW - Index Medicus KW - Animals KW - Protein Stability KW - Humans KW - Mutant Proteins -- chemistry KW - Mice KW - Mice, Inbred BALB C KW - Lung -- virology KW - Mutant Proteins -- immunology KW - Mutant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Genomic Instability KW - Vaccines, Attenuated -- immunology KW - Vaccines, Attenuated -- genetics KW - Amino Acid Substitution KW - Cell Line KW - Female KW - Cricetinae KW - Respiratory Syncytial Virus, Human -- genetics KW - Respiratory Syncytial Virus Vaccines -- immunology KW - Hot Temperature KW - Respiratory Syncytial Virus, Human -- pathogenicity KW - Respiratory Syncytial Virus, Human -- immunology KW - Respiratory Syncytial Virus Vaccines -- genetics KW - Mutation, Missense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67614911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Codon+stabilization+analysis+of+the+%22248%22+temperature+sensitive+mutation+for+increased+phenotypic+stability+of+respiratory+syncytial+virus+vaccine+candidates.&rft.au=Luongo%2C+Cindy%3BYang%2C+Lijuan%3BWinter%2C+Christine+C%3BSpann%2C+Kirsten+M%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L%3BBuchholz%2C+Ursula+J&rft.aulast=Luongo&rft.aufirst=Cindy&rft.date=2009-09-18&rft.volume=27&rft.issue=41&rft.spage=5667&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2009.07.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-16 N1 - Date created - 2009-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1999 Oct 20;282(15):1440-6 [10535434] N Engl J Med. 2009 Feb 5;360(6):588-98 [19196675] J Infect Dis. 2000 Nov;182(5):1331-42 [11010838] J Virol. 2001 Dec;75(24):12128-40 [11711604] J Virol. 2004 Feb;78(4):2029-36 [14747567] JAMA. 1968 May 20;204(8):690-4 [5694511] J Virol. 1969 Apr;3(4):414-21 [4890619] J Infect Dis. 1971 Nov;124(5):505-11 [4940177] Infect Immun. 1982 Jul;37(1):397-400 [7107009] J Virol. 1989 Jul;63(7):2941-50 [2470922] Proc Natl Acad Sci U S A. 1989 May;86(10):3699-703 [2657727] Vaccine. 1990 Oct;8(5):497-502 [2251875] Vaccine. 1993 Nov;11(14):1395-404 [8310760] Vaccine. 1994 Jun;12(8):691-9 [8091846] Vaccine. 1994 Jul;12(9):783-90 [7975856] Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11563-7 [8524804] Virus Genes. 1996;13(3):269-73 [9035372] J Infect Dis. 1997 Dec;176(6):1428-36 [9395351] Virology. 1998 Aug 1;247(2):232-9 [9705916] J Virol. 1999 Feb;73(2):871-7 [9882287] J Virol. 1999 Jan;73(1):251-9 [9847328] J Infect Dis. 2005 Apr 1;191(7):1093-104 [15747245] Proc Am Thorac Soc. 2005;2(2):166-73 [16113487] Virus Res. 2006 Jan;115(1):9-15 [16099066] J Virol Methods. 2006 Jul;135(1):91-101 [16569439] J Virol. 2008 Mar;82(5):2040-55 [17928346] Science. 2008 Jun 27;320(5884):1784-7 [18583614] Vaccine. 2000 Mar 6;18(17):1763-72 [10699324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2009.07.022 ER - TY - JOUR T1 - A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. AN - 67479508; 19375854 AB - Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) and COX-2 are involved in cellular processes such as inflammation, apoptosis, and tumorigenesis. To address the relationship between COX-2 and NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/+) mice, and COX-2(-/-) mice. While COX-2 expression is highly induced in tumor tissue, NAG-1 expression is reduced. Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression. The results suggest that a possible inverse relationship exists between the expression of NAG-1 and COX-2 in tumor formation of colon tissue. JF - Cancer letters AU - Iguchi, Genzo AU - Chrysovergis, Kali AU - Lee, Seong-Ho AU - Baek, Seung Joon AU - Langenbach, Robert AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, RTP, NC 27709, USA. Y1 - 2009/09/18/ PY - 2009 DA - 2009 Sep 18 SP - 152 EP - 158 VL - 282 IS - 2 KW - GDF15 protein, human KW - 0 KW - Gdf15 protein, mouse KW - Growth Differentiation Factor 15 KW - Pyrazoles KW - Sulfonamides KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Celecoxib KW - JCX84Q7J1L KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Pyrazoles -- pharmacology KW - Animals KW - Dinoprostone -- pharmacology KW - Sulfonamides -- pharmacology KW - Humans KW - Mice, Inbred C57BL KW - Mice KW - Gene Expression Regulation -- drug effects KW - Intestinal Polyps -- metabolism KW - Cyclooxygenase 2 -- genetics KW - Growth Differentiation Factor 15 -- genetics KW - Colorectal Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67479508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=A+reciprocal+relationship+exists+between+non-steroidal+anti-inflammatory+drug-activated+gene-1+%28NAG-1%29+and+cyclooxygenase-2.&rft.au=Iguchi%2C+Genzo%3BChrysovergis%2C+Kali%3BLee%2C+Seong-Ho%3BBaek%2C+Seung+Joon%3BLangenbach%2C+Robert%3BEling%2C+Thomas+E&rft.aulast=Iguchi&rft.aufirst=Genzo&rft.date=2009-09-18&rft.volume=282&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2009.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-30 N1 - Date created - 2009-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.canlet.2009.03.006 ER - TY - JOUR T1 - Plantar erythrodysesthesia with bullous otitis externa, toxicities from sorafenib: a case report. AN - 734142080; 19918567 AB - Lung cancer is the leading cause of cancer death worldwide and the use of novel agents, such as sorafenib has now demonstrated activity in Non Small Cell Lung Cancer. We present a case of a 77-year-old Caucasian male with advanced adenocarcinoma of the lung, who was being treated on clinical trial with single agent sorafenib. After seven weeks of treatment the patient presented to clinic with difficulty walking. Physical exam revealed acral erythema with bollous formation on bilateral soles of his feet. Otoscopic exam revealed bilateral external canal bullous lesion. The patient was diagnosed with plantar erythrodysesthesia with bullous otitis externa, a new toxicities in patients being treated with sorafenib. JF - Cases journal AU - Carter, Corey A AU - Rajan, Arun AU - Giaccone, Giuseppe AD - CCR, National Cancer Institute, 10 Center Drive, Building 10, Room 12N226, Bethesda, MD 20892, USA. carterca3@mail.nih.gov Y1 - 2009/09/16/ PY - 2009 DA - 2009 Sep 16 SP - 6264 VL - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734142080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cases+journal&rft.atitle=Plantar+erythrodysesthesia+with+bullous+otitis+externa%2C+toxicities+from+sorafenib%3A+a+case+report.&rft.au=Carter%2C+Corey+A%3BRajan%2C+Arun%3BGiaccone%2C+Giuseppe&rft.aulast=Carter&rft.aufirst=Corey&rft.date=2009-09-16&rft.volume=2&rft.issue=&rft.spage=6264&rft.isbn=&rft.btitle=&rft.title=Cases+journal&rft.issn=1757-1626&rft_id=info:doi/10.4076%2F1757-1626-2-6264 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-07 N1 - Date created - 2009-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Clin Oncol. 2002 Dec;25(6):599-602 [12478008] J Clin Oncol. 2009 Sep 10;27(26):4274-80 [19652055] Br J Dermatol. 2008 Mar;158(3):592-6 [18070211] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] Invest New Drugs. 2010 Feb;28(1):91-7 [19238328] Clin Exp Med. 2007 Dec;7(4):127-34 [18188524] Oncologist. 2008 Oct;13(10):1084-96 [18838439] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Physiol Meas. 2008 Mar;29(3):341-8 [18367809] Anat Rec A Discov Mol Cell Evol Biol. 2006 Aug;288(8):877-84 [16835926] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4076/1757-1626-2-6264 ER - TY - JOUR T1 - A novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of T cells. AN - 734050476; 19756150 AB - At the early stages of carcinogenesis, the induction of tumor specific T cell mediated immunity seems to block the tumor growth and give protective anti-tumor immune response. However, tumor associated macrophages (TAMs) might play an immunosuppressive role and subvert this anti tumor immunity leading to tumor progression and metastasis. The Cu (II) complex, (chelate), copper N-(2-hydroxy acetophenone) glycinate (CuNG), synthesized by us, has previously been shown to have a potential usefulness in immunotherapy of multiple drug resistant cancers. The current study demonstrates that CuNG treatment of TAMs modulates their status from immunosuppressive to proimmunogenic nature. Interestingly, these activated TAMs produced high levels of IL-12 along with low levels of IL-10 that not only allowed strong Th1 response marked by generation of high levels of IFN-gamma but also reduced activation induced T cell death. Similarly, CuNG treatment of peripheral blood monocytes from chemotherapy and/or radiotherapy refractory cancer patients also modulated their cytokine status. Most intriguingly, CuNG treated TAMs could influence reprogramming of TGF-beta producing CD4(+)CD25(+) T cells toward IFN-gamma producing T cells. Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers through reprogramming of TAMs that in turn reprogram the T cells and reeducate the T helper function to elicit proper anti-tumorogenic Th1 response leading to effective reduction in tumor growth. JF - PloS one AU - Chatterjee, Shilpak AU - Mookerjee, Ananda AU - Basu, Jayati Mookerjee AU - Chakraborty, Paramita AU - Ganguly, Avishek AU - Adhikary, Arghya AU - Mukhopadhyay, Debanjan AU - Ganguly, Sudipto AU - Ganguli, Sudipta AU - Banerjee, Rajdeep AU - Ashraf, Mohammad AU - Biswas, Jaydip AU - Das, Pradeep K AU - Sa, Gourisankar AU - Chatterjee, Mitali AU - Das, Tanya AU - Choudhuri, Soumitra Kumar AD - Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2009/09/16/ PY - 2009 DA - 2009 Sep 16 SP - 1 VL - 4 IS - 9 KW - Chelating Agents KW - 0 KW - Interleukin-2 Receptor alpha Subunit KW - Organometallic Compounds KW - copper (N-2-hydroxyacetophenone)glycinate KW - Interleukin-10 KW - 130068-27-8 KW - Interleukin-12 KW - 187348-17-0 KW - Copper KW - 789U1901C5 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Interleukin-12 -- metabolism KW - Interleukin-10 -- metabolism KW - Neoplasm Metastasis KW - Mice KW - Leukocytes, Mononuclear -- immunology KW - Drug Resistance, Neoplasm KW - Th1 Cells KW - Interleukin-2 Receptor alpha Subunit -- biosynthesis KW - Immunotherapy -- methods KW - Immune System KW - Chelating Agents -- pharmacology KW - Macrophages -- immunology KW - Organometallic Compounds -- pharmacology KW - Glycine -- pharmacology KW - CD4-Positive T-Lymphocytes -- immunology KW - Glycine -- analogs & derivatives KW - Copper -- pharmacology KW - Copper -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734050476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=A+novel+copper+chelate+modulates+tumor+associated+macrophages+to+promote+anti-tumor+response+of+T+cells.&rft.au=Chatterjee%2C+Shilpak%3BMookerjee%2C+Ananda%3BBasu%2C+Jayati+Mookerjee%3BChakraborty%2C+Paramita%3BGanguly%2C+Avishek%3BAdhikary%2C+Arghya%3BMukhopadhyay%2C+Debanjan%3BGanguly%2C+Sudipto%3BGanguli%2C+Sudipta%3BBanerjee%2C+Rajdeep%3BAshraf%2C+Mohammad%3BBiswas%2C+Jaydip%3BDas%2C+Pradeep+K%3BSa%2C+Gourisankar%3BChatterjee%2C+Mitali%3BDas%2C+Tanya%3BChoudhuri%2C+Soumitra+Kumar&rft.aulast=Chatterjee&rft.aufirst=Shilpak&rft.date=2009-09-16&rft.volume=4&rft.issue=9&rft.spage=e7048&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-01 N1 - Date created - 2009-09-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2004 Jan;4(1):71-8 [14708027] Int J Cancer. 2009 Jul 15;125(2):367-73 [19378341] Novartis Found Symp. 2004;256:158-68; discussion 168-72, 259-69 [15027489] J Leukoc Biol. 2004 Sep;76(3):509-13 [15218057] J Immunol. 1991 May 15;146(10):3444-51 [1827484] Eur J Cancer. 1991;27(6):781-5 [1712608] Science. 1991 Dec 13;254(5038):1643-7 [1840703] Pharmacol Ther. 1991;51(2):195-216 [1784630] J Exp Med. 1993 Apr 1;177(4):1199-204 [8096238] Science. 1993 Apr 23;260(5107):547-9 [8097338] J Exp Med. 1993 Oct 1;178(4):1223-30 [8104230] J Immunol. 1994 Aug 15;153(4):1697-706 [7913943] J Immunol. 1995 Aug 15;155(4):2240-7 [7636270] Immunol Today. 1996 Mar;17(3):138-46 [8820272] Cancer Res. 1996 Oct 15;56(20):4625-9 [8840975] J Exp Med. 1997 Jun 16;185(12):2101-10 [9182682] Am J Clin Nutr. 1998 May;67(5 Suppl):1064S-1068S [9587153] J Leukoc Biol. 1998 Sep;64(3):275-90 [9738653] Anticancer Drugs. 1998 Oct;9(9):825-32 [9840730] J Exp Med. 1998 Dec 21;188(12):2357-68 [9858522] Nat Rev Immunol. 2004 Nov;4(11):841-55 [15516964] J Biol Chem. 2005 Jan 14;280(2):1037-43 [15522880] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3023-8 [14978277] Nat Immunol. 2000 Dec;1(6):469-74 [11101867] J Immunother. 2001 Nov-Dec;24(6):431-46 [11759067] Int Immunol. 2002 Feb;14(2):201-12 [11809739] J Exp Med. 2002 Oct 7;196(7):999-1005 [12370261] Trends Immunol. 2002 Nov;23(11):549-55 [12401408] Nat Rev Immunol. 2002 Dec;2(12):933-44 [12461566] Nat Rev Immunol. 2003 Jan;3(1):23-35 [12511873] Clin Cancer Res. 2003 Jul;9(7):2487-96 [12855622] Nat Immunol. 2003 Sep;4(9):835-42 [12942084] Eur J Med Chem. 2003 Oct;38(10):893-8 [14575936] Cancer Metastasis Rev. 2005 Jan;24(1):95-105 [15785875] Nat Rev Cancer. 2005 Apr;5(4):263-74 [15776005] J Immunol. 2005 Jul 1;175(1):342-9 [15972667] Antimicrob Agents Chemother. 2006 May;50(5):1788-97 [16641451] Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4339-49 [16857809] Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G820-9 [17030898] J Immunol. 2007 Feb 1;178(3):1357-62 [17237382] EMBO Rep. 2007 Mar;8(3):224-7 [17304237] Immunol Res. 2006;36(1-3):275-82 [17337788] Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4345-54 [17671115] Antimicrob Agents Chemother. 2008 Mar;52(3):1080-93 [18056276] Gastroenterology. 2008 Jul;135(1):234-43 [18485901] Biometals. 2009 Apr;22(2):377-84 [18956143] Erratum In: PLoS One. 2015;10(1):e0117629 [25629165] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0007048 ER - TY - JOUR T1 - Influence of melanosome dynamics on melanoma drug sensitivity. AN - 67656294; 19704071 AB - Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood. Here we propose and test a model that explains drug resistance or sensitivity in terms of melanosome dynamics. The growth and sensitivity to cisplatin of MNT-1 cells, which are melanotic and enriched with mature stage III and IV melanosomes, and SK-MEL-28 cells, which have only immature stage I and II melanosomes, were compared using clonogenic assays. Differences in pigmentation, melanosome stages, melanosome number, and cellular structures in different cell lines in response to various treatments were examined by electron microscopy. The relative numbers of melanosomes of different stages were compared after treatment with 1-phenyl-2-thiourea. The relationship between drug transporter function and endogenous melanogenic toxicity was assessed by treating cells with the cyclosporin analog PSC-833 and by assessing vacuole formation and cell growth inhibition. All statistical tests were two-sided. Endogenous melanogenic cytotoxicity, produced by damaged melanosomes, resulted in pronounced cell growth inhibition in MNT-1 cells compared with amelanotic SK-MEL-28 cells. The sensitivity to CDDP of MNT-1 cells was 3.8-fold higher than that of SK-MEL-28 cells (mean IC(50) for SK-MEL-28 and MNT-1 = 2.13 microM and 0.56 microM, respectively; difference = 1.57 microM, 95% confidence interval = 1.45 to 1.69; P = .0017). After treatment with 6.7 microM CDDP for 72 hours, the number of stage II-III melanosomes in surviving MNT-1 cells was 6.8-fold that of untreated cells. Modulation of MNT-1 cells to earlier-stage (II, II-III, III) melanosomes by treatment with the tyrosinase inhibitor 1-phenyl-2-thiourea dramatically increased CDDP resistance. Furthermore, PSC-833 principally suppressed MNT-1 melanotic cell growth via an elevation of autophagosome-like vacuolar structures, possibly by inhibiting melanosome membrane transporters. Melanosome dynamics (including their biogenesis, density, status, and structural integrity) regulate the drug resistance of melanoma cells. Manipulation of melanosome functions may be an effective way to enhance the therapeutic activity of anticancer drugs against melanoma. JF - Journal of the National Cancer Institute AU - Chen, Kevin G AU - Leapman, Richard D AU - Zhang, Guofeng AU - Lai, Barry AU - Valencia, Julio C AU - Cardarelli, Carol O AU - Vieira, Wilfred D AU - Hearing, Vincent J AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 2108, Bethesda, MD 20892, USA. Y1 - 2009/09/16/ PY - 2009 DA - 2009 Sep 16 SP - 1259 EP - 1271 VL - 101 IS - 18 KW - Cyclosporins KW - 0 KW - Vinblastine KW - 5V9KLZ54CY KW - Doxorubicin KW - 80168379AG KW - Verapamil KW - CJ0O37KU29 KW - Cisplatin KW - Q20Q21Q62J KW - valspodar KW - Q7ZP55KF3X KW - Index Medicus KW - Vinblastine -- pharmacology KW - Microscopy, Confocal KW - Animals KW - Fluorescent Antibody Technique, Indirect KW - Humans KW - Cell Line, Tumor KW - Mice KW - Cyclosporins -- pharmacology KW - Verapamil -- pharmacology KW - Cell Death -- drug effects KW - Melanoma, Experimental -- pathology KW - Doxorubicin -- pharmacology KW - Cisplatin -- pharmacology KW - Melanoma, Experimental -- drug therapy KW - Microscopy, Electron KW - Skin Neoplasms -- drug therapy KW - Melanoma -- pathology KW - Melanosomes -- drug effects KW - Melanoma -- drug therapy KW - Skin Neoplasms -- pathology KW - Drug Resistance, Neoplasm KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Melanosomes -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67656294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Influence+of+melanosome+dynamics+on+melanoma+drug+sensitivity.&rft.au=Chen%2C+Kevin+G%3BLeapman%2C+Richard+D%3BZhang%2C+Guofeng%3BLai%2C+Barry%3BValencia%2C+Julio+C%3BCardarelli%2C+Carol+O%3BVieira%2C+Wilfred+D%3BHearing%2C+Vincent+J%3BGottesman%2C+Michael+M&rft.aulast=Chen&rft.aufirst=Kevin&rft.date=2009-09-16&rft.volume=101&rft.issue=18&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjp259 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-21 N1 - Date created - 2009-09-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2002 Jan 25;277(4):2505-10 [11700317] Blood. 2001 Dec 1;98(12):3212-20 [11719356] Mol Biol Cell. 2002 Jun;13(6):1953-64 [12058062] J Invest Dermatol. 2002 Jun;118(6):923-32 [12060385] Mol Biol Cell. 2002 Dec;13(12):4206-20 [12475946] Oncogene. 2003 May 19;22(20):3138-51 [12789290] J Invest Dermatol. 2003 Jul;121(1):172-6 [12839578] J Biol Chem. 2003 Nov 21;278(47):47156-65 [12960149] J Biol Chem. 2004 Jan 2;279(1):288-98 [14576150] Oncogene. 2004 Jan 8;23(1):30-8 [14712208] Exp Cell Res. 2004 Aug 15;298(2):317-28 [15265682] Clin Cancer Res. 2004 Jul 15;10(14):4724-33 [15269145] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] N Engl J Med. 2004 Sep 2;351(10):998-1012 [15342808] In Vitro Cell Dev Biol. 1987 Jul;23(7):519-22 [3610949] Ann Clin Lab Sci. 1990 Nov-Dec;20(6):379-84 [2073087] Cancer Res. 1994 Sep 15;54(18):4980-7 [7915196] J Biol Chem. 1997 Feb 28;272(9):5974-82 [9038218] Cancer Chemother Pharmacol. 1997;40 Suppl:S13-9 [9272128] J Natl Cancer Inst. 2004 Nov 17;96(22):1702-13 [15547183] J Dermatol Sci. 2005 Jan;37(1):3-14 [15619429] Pigment Cell Res. 2005 Apr;18(2):102-12 [15760339] Cancer Res. 2005 Oct 15;65(20):9328-37 [16230395] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Front Biosci. 2006;11:2157-73 [16720302] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9903-7 [16777967] J Clin Oncol. 2006 Jul 1;24(19):3157-63 [16809738] Genes Dev. 2006 Aug 15;20(16):2149-82 [16912270] Science. 2006 Oct 6;314(5796):126-9 [16946036] J Biol Chem. 2007 Apr 13;282(15):11266-80 [17303571] Nature. 2007 Apr 12;446(7137):745-7 [17429391] Cancer Res. 2009 Feb 1;69(3):992-9 [19155314] Melanoma Res. 2000 Oct;10(5):499-505 [11095412] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10698-703 [11526213] Melanoma Res. 2001 Oct;11(5):469-76 [11595883] FASEB J. 2001 Oct;15(12):2149-61 [11641241] Traffic. 2002 Apr;3(4):237-48 [11929605] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djp259 ER - TY - JOUR T1 - Serum Insulin, Glucose, Indices of Insulin Resistance, and Risk of Prostate Cancer AN - 21159802; 11096179 AB - Background The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear.Methods We investigated the relationship of the level of serum insulin, glucose, and surrogate indices of insulin resistance (ie, the molar ratio of insulin to glucose and the homeostasis model assessment of insulin resistance [HOMA-IR]) to the development of prostate cancer in a case-cohort study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of Finnish men. We studied 100 case subjects with incident prostate cancer and 400 noncase subjects without prostate cancer from the larger cohort. Fasting serum was collected 5-12 years before diagnosis. We determined insulin concentrations with a double-antibody immunochemiluminometric assay and glucose concentrations with a hexokinase assay. Multivariable logistic regression models estimated relative risks as odds ratios (ORs), and all statistical tests were two-sided.Results Insulin concentrations in fasting serum that was collected on average 9.2 years before diagnosis among case subjects were 8% higher than among noncase subjects, and the molar ratio of insulin to glucose and HOMA-IR were 10% and 6% higher, respectively, but these differences were not statistically significant. Among subjects in the second through fourth insulin quartiles, compared with those in the first quartile, increased insulin levels were associated with statistically significantly increased risks of prostate cancer (OR = 1.50, 95% confidence interval [CI] = 0.75 to 3.03; OR = 1.75, 95% CI = 0.86 to 3.56; and OR = 2.55, 95% CI = 1.18 to 5.51; for the second through fourth insulin quartiles, respectively; P sub(trend) = .02). A similar pattern was observed with the HOMA-IR (OR = 2.10, 95% CI = 1.03 to 4.26; P sub(trend) = .02) for the highest vs lowest quartiles. Risk varied inconsistently with glucose concentration (P sub(trend) = .38). A stronger association between insulin level and prostate cancer risk was observed among leaner men and among men who were less physically active at work. Crude prostate cancer incidence was 154 prostate cancers per 100000 person-years in the lowest quartile of fasting serum insulin vs 394 prostate cancers per 100000 person-years in the highest quartile.Conclusion Elevated fasting levels of serum insulin (but not glucose) within the normal range appear to be associated with a higher risk of prostate cancer. JF - Journal of the National Cancer Institute AU - Albanes, Demetrius AU - Weinstein, Stephanie J AU - Wright, Margaret E AU - Maennistoe, Satu AU - Limburg, Paul J AU - Snyder, Kirk AU - Virtamo, Jarmo Y1 - 2009/09/16/ PY - 2009 DA - 2009 Sep 16 SP - 1272 EP - 1279 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 18 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - insulin KW - Carcinogenesis KW - prevention KW - prostate cancer KW - growth factors KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21159802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Serum+Insulin%2C+Glucose%2C+Indices+of+Insulin+Resistance%2C+and+Risk+of+Prostate+Cancer&rft.au=Albanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BWright%2C+Margaret+E%3BMaennistoe%2C+Satu%3BLimburg%2C+Paul+J%3BSnyder%2C+Kirk%3BVirtamo%2C+Jarmo&rft.aulast=Albanes&rft.aufirst=Demetrius&rft.date=2009-09-16&rft.volume=101&rft.issue=18&rft.spage=1272&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp260 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - insulin; Carcinogenesis; prevention; prostate cancer; growth factors; Cancer DO - http://dx.doi.org/10.1093/jnci/djp260 ER - TY - JOUR T1 - Refractory Disseminated Coccidioidomycosis and Mycobacteriosis in Interferon- gamma Receptor 1 Deficiency AN - 907148948; 14307953 AB - Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon- gamma receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon- gamma axis appears to be critical for control of coccidioidomycosis. JF - Clinical Infectious Diseases AU - Vinh, D C AU - Masannat, F AU - Dzioba, R B AU - Galgiani, J N AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10CRC, Rm. B3-4141 MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - e62 EP - e65 VL - 49 IS - 6 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Interleukin 12 KW - Mycobacteriosis KW - Coccidioidomycosis KW - Mutation KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907148948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Refractory+Disseminated+Coccidioidomycosis+and+Mycobacteriosis+in+Interferon-+gamma+Receptor+1+Deficiency&rft.au=Vinh%2C+D+C%3BMasannat%2C+F%3BDzioba%2C+R+B%3BGalgiani%2C+J+N%3BHolland%2C+S+M&rft.aulast=Vinh&rft.aufirst=D&rft.date=2009-09-15&rft.volume=49&rft.issue=6&rft.spage=e62&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F605532 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Interleukin 12; gamma -Interferon; Mycobacteriosis; Coccidioidomycosis; Mutation DO - http://dx.doi.org/10.1086/605532 ER - TY - JOUR T1 - Undifferentiated nasopharyngeal carcinoma from a nonendemic area: Protective role of HLA allele products presenting conserved EBV epitopes AN - 745642409; 13163110 AB - The role of genetic factors involved in the development of undifferentiated nasopharyngeal carcinoma (UNPC) in nonendemic areas has been poorly investigated. High-resolution human leukocyte antigen (HLA) class I genotyping carried out in 82 Italian UNPC patients and 286 bone marrow donors born in the same province showed that A*0201, B*1801, and B*3501, known to efficiently present Epstein-Barr virus (EBV)-derived epitopes, were significantly under-represented in UNPC patients. Moreover, the A*0201/B*1801 haplotype was significantly less frequent in UNPC cases, with a 90% reduced risk (odds ratio [OR] 0.1, 95% confidence interval [CI] = 0.0-0.5) to develop UNPC, suggesting an additive effect. Notably, all 5 BARF1 epitopes and 7 of the 8 LMP-2 epitopes known to bind A*0201 showed a fully conserved sequence in all the 31 Italian EBV isolates investigated. The 4 amino acid changes affecting the 436-447 LMP-2 epitope do not reduce, but rather increase in two cases, the predicted ability of variant epitopes to bind the HLA-A*0201 allele, as shown by immunoinformatic analysis. Moreover, a significantly increased risk for UNPC was associated with A*2601 (OR 2.4, 95% CI = 1.1-4.9) and B*4101 (OR 9.2, 95% CI = 2.5-34.3). These findings indicate that Italian UNPC patients have a distinct HLA-A and -B genotypic profile and suggest that the decreased risk for UNPC conferred by definite HLA class I molecules is probably related to their ability to efficiently present LMP-2 and BARF1 epitopes that are highly conserved in EBV isolates from this geographic region. These results have practical implications for the immunotherapy of UNPC. JF - International Journal of Cancer AU - Pasini, Elisa AU - Caggiari, Laura AU - Maso, Luigino Dal AU - Martorelli, Debora AU - Guidoboni, Massimo AU - Vaccher, Emanuela AU - Barzan, Luigi AU - Franchin, Giovanni AU - Gloghini, Annunziata AU - De Re, Valli AU - Sacchi, Nicoletta AU - Serraino, Diego AU - Carbone, Antonino AU - Rosato, Antonio AU - Dolcetti, Riccardo AD - Cancer Bioimmunotherapy Unit, IRCCS - National Cancer Institute, Aviano (PN), Italy, rdolcetti@cro.it rdolcetti@cro.it rdolcetti@cro.it rdolcetti@cro.it rdolcetti@cro.it rdolcetti@cro.it Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 1358 EP - 1364 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 6 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - Histocompatibility antigen HLA KW - Genetic factors KW - Amino acids KW - Immunotherapy KW - Genotyping KW - Bone marrow KW - haplotypes KW - Cancer KW - risk reduction KW - Epstein-Barr virus KW - Nasopharyngeal carcinoma KW - Haplotypes KW - Conserved sequence KW - Epitopes KW - Amino acid sequence KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Undifferentiated+nasopharyngeal+carcinoma+from+a+nonendemic+area%3A+Protective+role+of+HLA+allele+products+presenting+conserved+EBV+epitopes&rft.au=Pasini%2C+Elisa%3BCaggiari%2C+Laura%3BMaso%2C+Luigino+Dal%3BMartorelli%2C+Debora%3BGuidoboni%2C+Massimo%3BVaccher%2C+Emanuela%3BBarzan%2C+Luigi%3BFranchin%2C+Giovanni%3BGloghini%2C+Annunziata%3BDe+Re%2C+Valli%3BSacchi%2C+Nicoletta%3BSerraino%2C+Diego%3BCarbone%2C+Antonino%3BRosato%2C+Antonio%3BDolcetti%2C+Riccardo&rft.aulast=Pasini&rft.aufirst=Elisa&rft.date=2009-09-15&rft.volume=125&rft.issue=6&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24515 L2 - http://www3.interscience.wiley.com/journal/122337096/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Genetic factors; Nasopharyngeal carcinoma; Haplotypes; Genotyping; Immunotherapy; Bone marrow; Conserved sequence; Epitopes; Amino acid sequence; risk reduction; Amino acids; haplotypes; Cancer; Epstein-Barr virus DO - http://dx.doi.org/10.1002/ijc.24515 ER - TY - JOUR T1 - Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica AN - 745642302; 13163125 AB - We evaluated whether risk of non-Hodgkin lymphoma (NHL), particularly adult T-cell leukemia/lymphoma (ATL) related to human T-lymphotropic virus (HTLV) infection was associated with 63 single nucleotide polymorphisms (SNPs) from 38 candidate genes. The 395 NHL cases registered in Jamaica were matched by age, sex, calendar-year and HTLV serostatus to 309 controls from the same population. Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (ORAG/AA = 0.62,95% CI = 0.44-0.87, p = 0.006), as was vascular cell adhesion molecule-1, VCAM1 Ex9+149G>A SNP (rs1041163) (ORCT = 0.77, 95% CI = 0.54-1.10, ORCC=0.35, 95% CI = 0.16-0.76, p-trend = 0.007). Both results were stronger in analyses restricted to ATL cases and HTLV-positive controls, suggesting a role for these genes in ATL etiology (IL13 ORAG/AA = 0.54, 95% CI = 0.36-0.84, p = 0.005; VCAM1 ORCT = 0.65, 95% CI = 0.42-1.01, ORCC = 0.20, 95% CI = 0.08-0.54, p-trend = 0.001). Confirmation of these results in Caribbean and other populations is needed. JF - International Journal of Cancer AU - Wang, Sophia S AU - Carreon, J Daniel AU - Hanchard, Barrie AU - Chanock, Stephen AU - Hisada, Michie AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, wangso@mail.nih.gov Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 1479 EP - 1482 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 6 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - Human T-lymphotropic virus KW - non-Hodgkin's lymphoma KW - Age KW - Etiology KW - Infection KW - ASW, Caribbean Sea, Greater Antilles, Jamaica KW - Cancer KW - Leukemia KW - vascular cell adhesion molecule 1 KW - Interleukin 13 KW - Single-nucleotide polymorphism KW - infection KW - Lymphocytes T KW - adhesion KW - T-cell lymphoma KW - lymphoma KW - Sex KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Common+genetic+variants+and+risk+for+non-Hodgkin+lymphoma+and+adult+T-cell+lymphoma%2Fleukemia+in+Jamaica&rft.au=Wang%2C+Sophia+S%3BCarreon%2C+J+Daniel%3BHanchard%2C+Barrie%3BChanock%2C+Stephen%3BHisada%2C+Michie&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2009-09-15&rft.volume=125&rft.issue=6&rft.spage=1479&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24489 L2 - http://www3.interscience.wiley.com/journal/122322282/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - vascular cell adhesion molecule 1; Leukemia; Etiology; Interleukin 13; Single-nucleotide polymorphism; Lymphocytes T; Infection; T-cell lymphoma; Sex; non-Hodgkin's lymphoma; Age; infection; adhesion; lymphoma; Cancer; Human T-lymphotropic virus; ASW, Caribbean Sea, Greater Antilles, Jamaica DO - http://dx.doi.org/10.1002/ijc.24489 ER - TY - JOUR T1 - Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction AN - 745642072; 13163100 AB - Analogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anticancer activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to determine their mechanism of action. Dimers were >1,000 fold more active than monomer and treatment was associated with increased reactive oxygen species (ROS) and apoptosis induction. Dimer activity was inhibited by the antioxidant L-NAC, the iron chelator desferroxamine and exogenous hemin. Similarly, induction of heme oxygenase (HMOX) with CoPPIX inhibited activity, whereas inhibition of HMOX with SnPPIX enhanced it. These results emphasize the importance of iron, heme and ROS in activity. Microarray analysis of dimer treated cells identified DNA damage, iron/heme and cysteine/methionine metabolism, antioxidant response, and endoplasmic reticulum (ER) stress as affected pathways. Detection of an ER-stress response was relevant because in malaria, artemisinin inhibits pfATP6, the plasmodium orthologue of mammalian sarcoplasmic/endoplasmic reticulum Ca2+-ATPases (SERCA). A comparative study of NSC735847 with thapsigargin, a specific SERCA inhibitor and ER-stress inducer showed similar behavior in terms of transcriptomic changes, induction of endogenous SERCA and ER calcium mobilization. However, thapsigargin had little effect on ROS production, modulated different ER-stress proteins and had greater potency against purified SERCA1. Furthermore, an inactive derivative of NSC735847 that lacked the endoperoxide had identical inhibitory activity against purified SERCA1, suggesting that direct inhibition of SERCA has little inference on overall cytotoxicity. In summary, these data implicate indirect ER-stress induction as a central mechanism of artemisinin dimer activity. JF - International Journal of Cancer AU - Stockwin, Luke H AU - Han, Bingnan AU - Yu, Sherry X AU - Hollingshead, Melinda G AU - Elsohly, Mahmoud A AU - Gul, Waseem AU - Slade, Desmond AU - Galal, Ahmed M AU - Newton, Dianne L AD - Developmental Therapeutics Program, SAIC-Frederick, NCI-Frederick, Frederick, MD, dnewton@ncifcrf.gov Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 1266 EP - 1275 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 6 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Antioxidants KW - Apoptosis KW - Heme KW - Malaria KW - Hemin KW - Chelating agents KW - DNA microarrays KW - Methionine KW - Endoplasmic reticulum KW - Ca super(2+)-transporting ATPase KW - thapsigargin KW - Reactive oxygen species KW - Data processing KW - Stress KW - Heme oxygenase (decyclizing) KW - Monomers KW - DNA damage KW - Plasmodium KW - Cytotoxicity KW - Cysteine KW - Calcium mobilization KW - artemisinin KW - Iron KW - Metabolism KW - Antitumor activity KW - T 2010:Muscle KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Artemisinin+dimer+anticancer+activity+correlates+with+heme-catalyzed+reactive+oxygen+species+generation+and+endoplasmic+reticulum+stress+induction&rft.au=Stockwin%2C+Luke+H%3BHan%2C+Bingnan%3BYu%2C+Sherry+X%3BHollingshead%2C+Melinda+G%3BElsohly%2C+Mahmoud+A%3BGul%2C+Waseem%3BSlade%2C+Desmond%3BGalal%2C+Ahmed+M%3BNewton%2C+Dianne+L&rft.aulast=Stockwin&rft.aufirst=Luke&rft.date=2009-09-15&rft.volume=125&rft.issue=6&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24496 L2 - http://www3.interscience.wiley.com/journal/122309226/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Antioxidants; Heme; Stress; Heme oxygenase (decyclizing); Hemin; Malaria; Chelating agents; DNA microarrays; Methionine; Monomers; Ca super(2+)-transporting ATPase; Endoplasmic reticulum; DNA damage; Cytotoxicity; Reactive oxygen species; thapsigargin; Cysteine; Calcium mobilization; artemisinin; Iron; Metabolism; Antitumor activity; Plasmodium DO - http://dx.doi.org/10.1002/ijc.24496 ER - TY - JOUR T1 - Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. AN - 733968327; 19539749 AB - The peroxisome proliferator-activated receptor-alpha (PPARalpha) regulates lipid homeostasis, particularly in the liver. This study was aimed at elucidating the relationship between hepatosteatosis and oxidative stress during fasting. Fasted Ppara-null mice exhibited marked hepatosteatosis, which was associated with elevated levels of lipid peroxidation, nitric oxide synthase activity, and hydrogen peroxide accumulation. Total glutathione (GSH), mitochondrial GSH, and the activities of major antioxidant enzymes were also lower in the fasted Ppara-null mice. Consequently, the number and extent of nitrated proteins were markedly increased in the fasted Ppara-null mice, although high levels of protein nitration were still detected in the fed Ppara-null mice while many oxidatively modified proteins were only found in the fasted Ppara-null mice. However, the role of inflammation in increased oxidative stress in the fasted Ppara-null mice was minimal based on the similar levels of tumor necrosis factor-alpha change in all groups. These results with increased oxidative stress observed in the fasted Ppara-null mice compared with other groups demonstrate a role for PPAR alpha in fasting-mediated oxidative stress and that inhibition of PPAR alpha functions may increase the susceptibility to oxidative damage in the presence of another toxic agent. JF - Free radical biology & medicine AU - Abdelmegeed, Mohamed A AU - Moon, Kwan-Hoon AU - Hardwick, James P AU - Gonzalez, Frank J AU - Song, Byoung-Joon AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, 9000 Rockville Pike, Bethesda, MD 20892-9410, USA. Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 767 EP - 778 VL - 47 IS - 6 KW - Nitro Compounds KW - 0 KW - PPAR alpha KW - Tumor Necrosis Factor-alpha KW - Hydrogen Peroxide KW - BBX060AN9V KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Lipid Peroxidation -- genetics KW - Fatty Liver -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Glutathione -- metabolism KW - Fatty Liver -- genetics KW - Mice KW - Fatty Liver -- pathology KW - Tumor Necrosis Factor-alpha -- metabolism KW - Nitric Oxide Synthase -- metabolism KW - Nitro Compounds -- metabolism KW - Mice, Knockout KW - Oxidative Stress -- physiology KW - Liver -- pathology KW - Mitochondria, Liver -- metabolism KW - Mitochondria, Liver -- genetics KW - Liver -- metabolism KW - PPAR alpha -- metabolism KW - PPAR alpha -- genetics KW - Fasting -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733968327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Role+of+peroxisome+proliferator-activated+receptor-alpha+in+fasting-mediated+oxidative+stress.&rft.au=Abdelmegeed%2C+Mohamed+A%3BMoon%2C+Kwan-Hoon%3BHardwick%2C+James+P%3BGonzalez%2C+Frank+J%3BSong%2C+Byoung-Joon&rft.aulast=Abdelmegeed&rft.aufirst=Mohamed&rft.date=2009-09-15&rft.volume=47&rft.issue=6&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2009.06.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-01 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Hepatology. 2006 Nov;44(5):1218-30 [17058263] FEBS Lett. 2007 Aug 21;581(21):3967-72 [17673211] Toxicology. 2008 Apr 3;246(1):2-8 [18006136] Free Radic Biol Med. 2008 Apr 1;44(7):1259-72 [18242193] Biochem Pharmacol. 2008 Jun 15;75(12):2263-75 [18433732] J Hepatol. 2008 Aug;49(2):262-73 [18571270] Proteomics. 2008 Sep;8(18):3906-18 [18780394] Gastroenterology. 2008 Oct;135(4):1344-57 [18778711] Biochem J. 2009 Jan 1;417(1):183-93 [18752470] Chem Phys Lipids. 2009 Jan;157(1):1-11 [18977338] Alcohol Clin Exp Res. 2010 Feb;34 Suppl 1:S18-24 [18986378] Drug Metab Dispos. 1985 Sep-Oct;13(5):548-52 [2865101] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765] Physiol Genomics. 2004 Apr 13;17(2):230-44 [14762175] J Lipid Res. 2004 Nov;45(11):2025-37 [15342691] Annu Rev Biochem. 1983;52:711-60 [6137189] Gastroenterology. 1985 Nov;89(5):1123-31 [4043669] Biochem Biophys Res Commun. 1987 Feb 13;142(3):1077-83 [3827895] Mol Pharmacol. 1992 Mar;41(3):474-9 [1545775] Biochem Pharmacol. 1992 Apr 15;43(8):1868-71 [1575780] J Lab Clin Med. 1992 Jun;119(6):598-620 [1593209] Physiol Rev. 1994 Jan;74(1):139-62 [8295932] J Biol Chem. 1994 Jul 22;269(29):18767-72 [7913466] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9 [8041794] Arch Biochem Biophys. 1995 Jan 10;316(1):197-205 [7840616] Int J Biochem. 1994 Oct-Nov;26(10-11):1261-8 [7880321] Biochemistry. 1995 Feb 28;34(8):2592-8 [7873540] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Gene Expr. 1995;4(4-5):281-99 [7787419] Toxicol Lett. 1995 Nov;81(1):39-44 [8525497] Endocrinology. 1996 Jan;137(1):354-66 [8536636] FEBS Lett. 1996 Apr 29;385(1-2):63-6 [8641468] J Hepatol. 1996 Feb;24(2):200-8 [8907574] J Biol Chem. 1998 Mar 6;273(10):5678-84 [9488698] J Biol Chem. 1998 Jun 5;273(23):14085-9 [9603906] J Clin Invest. 1999 Jun;103(11):1489-98 [10359558] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8 [10377439] Endocr Rev. 1999 Oct;20(5):649-88 [10529898] Proteomics. 2004 Nov;4(11):3401-12 [15449375] J Biol Chem. 2004 Dec 10;279(50):52390-8 [15375163] J Pharmacol Exp Ther. 2005 Oct;315(1):203-13 [15980059] Chem Res Toxicol. 2006 Jan;19(1):102-10 [16411662] Free Radic Biol Med. 2006 Feb 1;40(3):453-8 [16443160] Mitochondrion. 2006 Feb;6(1):1-28 [16406828] Free Radic Res. 2006 Apr;40(4):339-47 [16517498] J Clin Invest. 2000 Apr;105(8):1067-75 [10772651] Arch Biochem Biophys. 2000 Aug 15;380(2):360-6 [10933892] Arch Pharm Res. 2000 Aug;23(4):267-82 [10976571] J Biol Chem. 2000 Sep 15;275(37):28918-28 [10844002] Biochem J. 2001 Apr 15;355(Pt 2):481-8 [11284737] Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48 [11804856] Arch Biochem Biophys. 2002 Feb 1;398(1):79-86 [11811951] Mol Pharmacol. 2003 Feb;63(2):401-8 [12527812] Med Sci Monit. 2003 Mar;9(3):BR131-5 [12640336] FASEB J. 2003 Sep;17(12):1748-50 [12958197] J Biol Chem. 2003 Sep 19;278(38):36027-31 [12840017] Curr Mol Med. 2003 Sep;3(6):561-72 [14527087] Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H22-9 [14527943] Annu Rev Pharmacol Toxicol. 2004;44:27-42 [14744237] Cell Mol Life Sci. 2004 Feb;61(4):393-416 [14999402] J Biol Chem. 2006 Jul 28;281(30):21256-65 [16709574] Hepatology. 2006 Sep;44(3):581-91 [16941682] Endocrinology. 2007 Jun;148(6):2753-63 [17347305] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2009.06.017 ER - TY - JOUR T1 - Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. AN - 733715682; 19737943 AB - Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer. This study examines the potential clinical utility of an inflammatory gene expression signature as a prognostic biomarker for colon cancer in addition to previously examined miR-21 expression. Quantitative reverse transcriptase-PCR. was used to measure the expression of 23 inflammatory genes in colon adenocarcinomas and adjacent noncancerous tissues from 196 patients. These data were used to develop models for cancer-specific mortality on a training cohort (n = 57), and this model was tested in both a test (n = 56) and a validation (n = 83) cohort. Expression data for miR-21 were available for these patients and were compared and combined with inflammatory gene expression. PRG1, IL-10, CD68, IL-23a, and IL-12a expression in noncancerous tissue, and PRG1, ANXA1, IL-23a, IL-17a, FOXP3, and HLA-DRA expression in tumor tissues were associated with poor prognosis based on Cox regression (/Z-score/ >1.5) and were used to generate the inflammatory risk score (IRS). IRS was associated with cancer-specific mortality in the training, test (P = 0.01), and validation (P = 0.02) cohorts. This association was strong for stage II cases (P = 0.002). Expression of miR-21 was associated with IL-6, IL-8, IL-10, IL-12a, and NOS2a, providing evidence that the function of this microRNA and these inflammatory genes are linked. Both IRS and miR-21 expression were independently associated with cancer-specific mortality, including stage II patients alone. IRS and miR-21 expression are independent predictors of colon cancer prognosis and may provide a clinically useful tool to identify high-risk patients. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Schetter, Aaron J AU - Nguyen, Giang Huong AU - Bowman, Elise D AU - Mathé, Ewy A AU - Yuen, Siu Tsan AU - Hawkes, Jason E AU - Croce, Carlo M AU - Leung, Suet Yi AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 5878 EP - 5887 VL - 15 IS - 18 SN - 1078-0432, 1078-0432 KW - Biomarkers, Tumor KW - 0 KW - Cytokines KW - MIRN21 microRNA, human KW - MicroRNAs KW - Index Medicus KW - Cytokines -- genetics KW - Humans KW - Prognosis KW - Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Profiling KW - Survival Rate KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Middle Aged KW - Female KW - Male KW - Adenocarcinoma -- diagnosis KW - Biomarkers, Tumor -- genetics KW - Colonic Neoplasms -- genetics KW - MicroRNAs -- genetics KW - Colonic Neoplasms -- mortality KW - Adenocarcinoma -- mortality KW - Inflammation -- genetics KW - Adenocarcinoma -- genetics KW - Colonic Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733715682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Association+of+inflammation-related+and+microRNA+gene+expression+with+cancer-specific+mortality+of+colon+adenocarcinoma.&rft.au=Schetter%2C+Aaron+J%3BNguyen%2C+Giang+Huong%3BBowman%2C+Elise+D%3BMath%C3%A9%2C+Ewy+A%3BYuen%2C+Siu+Tsan%3BHawkes%2C+Jason+E%3BCroce%2C+Carlo+M%3BLeung%2C+Suet+Yi%3BHarris%2C+Curtis+C&rft.aulast=Schetter&rft.aufirst=Aaron&rft.date=2009-09-15&rft.volume=15&rft.issue=18&rft.spage=5878&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0627 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-30 N1 - Date created - 2009-09-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2003 Apr 1;101(7):2620-7 [12411307] Med Oncol. 2009;26 Suppl 1:13-7 [19148594] N Engl J Med. 2004 Apr 29;350(18):1828-37 [15115829] Lancet. 1987 Jun 6;1(8545):1303-6 [2884421] Lancet. 1990 Aug 11;336(8711):357-9 [1975343] N Engl J Med. 1990 Nov 1;323(18):1228-33 [2215606] Int J Cancer. 1999 Jun 21;84(3):326-30 [10371355] Cancer Res. 1999 Aug 1;59(15):3698-704 [10446984] Cell. 2005 Mar 11;120(5):635-47 [15766527] Nature. 2005 Jun 9;435(7043):828-33 [15944707] J Immunol. 2005 Nov 1;175(9):6177-89 [16237115] N Engl J Med. 2005 Oct 27;353(17):1793-801 [16251535] Immunity. 2000 Nov;13(5):715-25 [11114383] Cancer. 2001 Feb 15;91(4):854-62 [11241255] Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G1035-44 [12016129] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8 [12518062] Nat Rev Immunol. 2003 Feb;3(2):133-46 [12563297] N Engl J Med. 2005 Dec 22;353(25):2654-66 [16371631] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] Science. 2006 Sep 29;313(5795):1960-4 [17008531] Cancer Biother Radiopharm. 2006 Oct;21(5):468-87 [17105420] Annu Rev Med. 2007;58:239-52 [17100552] Eur J Cancer. 2007 Mar;43(4):762-8 [17258448] J Clin Invest. 2007 May;117(5):1175-83 [17476347] Blood. 2007 Aug 15;110(4):1330-3 [17496199] BMC Genomics. 2007;8:240 [17640343] J Natl Cancer Inst. 2007 Aug 15;99(16):1257-69 [17686824] Int J Cancer. 2007 Dec 1;121(11):2373-80 [17893866] PLoS One. 2007;2(10):e1020 [17925868] Nucleic Acids Res. 2008 Jan;36(Database issue):D149-53 [18158296] Cancer Metastasis Rev. 2008 Mar;27(1):11-8 [18066650] JAMA. 2008 Jan 30;299(4):425-36 [18230780] Lancet. 2008 Mar 1;371(9614):771-83 [18275997] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Expert Rev Anticancer Ther. 2008 Apr;8(4):595-604 [18402526] J Mol Biol. 2008 May 2;378(3):492-504 [18384814] Gastroenterology. 2008 May;134(5):1296-310 [18471507] Gut. 2008 Jun;57(6):772-9 [17965063] N Engl J Med. 2008 Jun 19;358(25):2664-5 [18565858] Carcinogenesis. 2008 Jun;29(6):1202-6 [18448485] Immunol Rev. 2008 Jun;223:114-31 [18613832] Ann Oncol. 2008 Oct;19(10):1734-41 [18550579] Clin Cancer Res. 2008 Nov 1;14(21):6735-41 [18980965] Genome Res. 2009 Jan;19(1):92-105 [18955434] J Immunol. 2003 Jul 15;171(2):600-7 [12847224] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0627 ER - TY - JOUR T1 - Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma. AN - 67648426; 19536874 AB - Emerging data suggest that cutaneous malignant melanomas (CMM) may arise through divergent cancer pathways that are linked to intermittent versus accumulated sun exposure. However, numerous questions remain regarding the timing and/or age of exposure. The authors systematically examined the effect of aging on CMM incidence in data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Standard descriptive epidemiology was supplemented with mathematical models. The impact of advancing age on CMM incidence was assessed by sex, histopathologic classification (superficial spreading melanoma [SSM] or lentigo maligna melanoma [LMM]), and anatomic site (face, head, and neck [FHN] or lower extremity [LE]). Sex, histopathology, and anatomic site were age-specific effect modifiers for CMM that indicated divergent (bimodal) early-onset and late-onset cancer pathways. Early-onset melanomas were associated predominantly with women, SSM, and LE. Late-onset melanomas were correlated with men, LMM, and FHN. Early- and late-onset melanoma populations were confirmed with age-period-cohort models that were adjusted for period and cohort effects. Two-component mixture models also fit the data better than a single cancer population. The current results were consistent with a divergent and age-dependent solar hypothesis for CMM. Early-onset melanomas may represent gene-sun exposure interactions that occur early (and/or intermittently) in life among susceptible individuals. Late-onset melanomas may reflect accumulated, lifelong sun exposure in comparatively less susceptible individuals. Future analytical studies should be powered adequately to account for this age-dependent effect modification both for acknowledged melanoma risk factors (sex, histopathology, and anatomic site) and for suspected melanoma risk factors, such as constituent genetic variants. JF - Cancer AU - Anderson, William F AU - Pfeiffer, Ruth M AU - Tucker, Margaret A AU - Rosenberg, Philip S AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892-7244, USA. wanderso@mail.nih.gov Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 4176 EP - 4185 VL - 115 IS - 18 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - SEER Program KW - Adult KW - Incidence KW - Aged KW - Models, Statistical KW - Middle Aged KW - Male KW - Female KW - Age of Onset KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Melanoma -- etiology KW - Skin Neoplasms -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67648426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Divergent+cancer+pathways+for+early-onset+and+late-onset+cutaneous+malignant+melanoma.&rft.au=Anderson%2C+William+F%3BPfeiffer%2C+Ruth+M%3BTucker%2C+Margaret+A%3BRosenberg%2C+Philip+S&rft.aulast=Anderson&rft.aufirst=William&rft.date=2009-09-15&rft.volume=115&rft.issue=18&rft.spage=4176&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24481 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2000 Mar 1;85(5):627-32 [10699940] Epidemiology. 2001 Sep;12(5):552-7 [11505175] J Clin Oncol. 2001 Aug 15;19(16):3635-48 [11504745] Breast Cancer Res Treat. 2002 Nov;76(1):27-36 [12408373] J Natl Cancer Inst. 2003 Jun 4;95(11):806-12 [12783935] J Natl Cancer Inst. 2003 Dec 17;95(24):1878-90 [14679157] Clin Cancer Res. 2004 May 15;10(10):3444-7 [15161700] Cancer. 1967 May;20(5):632-49 [6024276] Cancer Res. 1969 Mar;29(3):705-27 [5773814] Pathology. 1970 Apr;2(2):85-98 [5520514] Int J Epidemiol. 1974 Dec;3(4):325-32 [4435983] Semin Oncol. 1975 Jun;2(2):83-103 [790575] Am J Epidemiol. 1977 May;105(5):420-7 [860705] Hum Pathol. 1980 Nov;11(6):591-5 [7450735] Biometrics. 1983 Jun;39(2):311-24 [6626659] Biometrics. 1985 Jun;41(2):361-72 [4027319] Pathology. 1986 Jan;18(1):12-21 [3725419] J Clin Epidemiol. 1991;44(3):221-32 [1999681] Cancer Causes Control. 1991 Nov;2(6):401-11 [1764565] Int J Cancer. 1997 Oct 9;73(2):198-203 [9335442] Int J Cancer. 1998 Sep 11;77(6):843-8 [9714052] Cancer Causes Control. 2005 Apr;16(3):193-9 [15947871] Int J Cancer. 2005 Nov 10;117(3):486-93 [15900597] N Engl J Med. 2005 Nov 17;353(20):2135-47 [16291983] Science. 2006 Jul 28;313(5786):521-2 [16809487] J Clin Oncol. 2006 Sep 10;24(26):4340-6 [16908931] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1899-905 [17035397] J Clin Oncol. 2007 Apr 20;25(12):1606-20 [17443002] J Invest Dermatol. 2008 Jan;128(1):243-5 [17713570] Biostatistics. 2008 Jan;9(1):137-51 [17566074] Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):467-8 [18319329] J Natl Cancer Inst. 2008 Dec 17;100(24):1804-14 [19066264] Comment In: Cancer. 2010 May 15;116(10):2499; author reply 2500 [20225335] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.24481 ER - TY - JOUR T1 - ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. AN - 67506180; 19437536 AB - Inhibitor of growth 2 (ING2) is associated with chromatin remodeling and regulation of gene expression by binding to a methylated histone H3K4 residue and recruiting HDAC complexes to the region. The aim of our study is to investigate the regulation of ING2 expression and the clinical significance of upregulated ING2 in colon cancer. Here, we show that the ING2 mRNA level in colon cancer tissue increased to more than twice than that in normal mucosa in the 45% of colorectal cancer cases that we examined. A putative NF-kappaB binding site was found in the ING2 promoter region. We confirmed that NF-kappaB could bind to the ING2 promoter by EMSA and luciferase assays. Subsequent microarray analyses revealed that ING2 upregulates expression of matrix metalloproteinase 13 (MMP13), which enhances cancer invasion and metastasis. ING2 regulation of MMP13 expression was confirmed in both ING2 overexpression and knock down experiments. MMP13 expression was further induced by coexpression of ING2 with HDAC1 or with mSin3A, suggesting that the ING2-HDAC1-mSin3A complex members regulates expression of MMP13. In vitro invasion assay was performed to determine functional significance of ING2 upregulation. ING2 overexpressed cells exhibited greater invasive potential. Taken together, upregulation of ING2 was associated with colon cancer and MMP13-dependent cellular invasion, indicating that ING2 expression might be involved with cancer invasion and metastasis. 2009 UICC JF - International journal of cancer AU - Kumamoto, Kensuke AU - Fujita, Kaori AU - Kurotani, Reiko AU - Saito, Motonobu AU - Unoki, Motoko AU - Hagiwara, Nobutoshi AU - Shiga, Hideaki AU - Bowman, Elise D AU - Yanaihara, Nozomu AU - Okamura, Shu AU - Nagashima, Makoto AU - Miyamoto, Kotaro AU - Takenoshita, Seiichi AU - Yokota, Jun AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 1306 EP - 1315 VL - 125 IS - 6 KW - Biomarkers, Tumor KW - 0 KW - Homeodomain Proteins KW - ING2 protein, human KW - NF-kappa B KW - RNA, Messenger KW - Receptors, Cytoplasmic and Nuclear KW - Repressor Proteins KW - SIN3A transcription factor KW - Tumor Suppressor Proteins KW - Luciferases KW - EC 1.13.12.- KW - MMP13 protein, human KW - EC 3.4.24.- KW - Matrix Metalloproteinase 13 KW - HDAC1 protein, human KW - EC 3.5.1.98 KW - Histone Deacetylase 1 KW - Histone Deacetylases KW - Index Medicus KW - Neoplasm Invasiveness KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Repressor Proteins -- metabolism KW - Electrophoretic Mobility Shift Assay KW - Luciferases -- metabolism KW - Immunoprecipitation KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Repressor Proteins -- genetics KW - NF-kappa B -- genetics KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Transfection KW - Histone Deacetylases -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Promoter Regions, Genetic -- genetics KW - Middle Aged KW - Up-Regulation KW - Histone Deacetylases -- genetics KW - Immunoenzyme Techniques KW - NF-kappa B -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Colonic Neoplasms -- genetics KW - Homeodomain Proteins -- genetics KW - Tumor Suppressor Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Colonic Neoplasms -- metabolism KW - Matrix Metalloproteinase 13 -- genetics KW - Colonic Neoplasms -- pathology KW - Matrix Metalloproteinase 13 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67506180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=ING2+is+upregulated+in+colon+cancer+and+increases+invasion+by+enhanced+MMP13+expression.&rft.au=Kumamoto%2C+Kensuke%3BFujita%2C+Kaori%3BKurotani%2C+Reiko%3BSaito%2C+Motonobu%3BUnoki%2C+Motoko%3BHagiwara%2C+Nobutoshi%3BShiga%2C+Hideaki%3BBowman%2C+Elise+D%3BYanaihara%2C+Nozomu%3BOkamura%2C+Shu%3BNagashima%2C+Makoto%3BMiyamoto%2C+Kotaro%3BTakenoshita%2C+Seiichi%3BYokota%2C+Jun%3BHarris%2C+Curtis+C&rft.aulast=Kumamoto&rft.aufirst=Kensuke&rft.date=2009-09-15&rft.volume=125&rft.issue=6&rft.spage=1306&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24437 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2006 Jan 6;21(1):51-64 [16387653] Mol Cell. 2006 Jun 9;22(5):669-79 [16762839] Biochim Biophys Acta. 2004 May 25;1678(2-3):111-25 [15157737] Carcinogenesis. 2004 Oct;25(10):1991-2003 [15192014] Int J Colorectal Dis. 2004 Nov;19(6):518-24 [15103490] Oncogene Res. 1988;3(4):401-8 [3067190] Biochim Biophys Acta. 1991 Apr 16;1072(1):63-80 [2018779] Br J Cancer. 2006 Jul 3;95(1):80-6 [16755297] Nature. 2006 Jul 6;442(7098):96-9 [16728974] Nature. 2006 Jul 6;442(7098):100-3 [16728977] Mol Cell. 2006 Sep 1;23(5):685-95 [16949365] J Biol Chem. 2006 Sep 29;281(39):28831-6 [16893883] Sci STKE. 2006 Nov 7;2006(360):pe46 [17090802] Mol Cell Biol. 2006 Dec;26(24):9244-55 [17030616] Nature. 2007 May 24;447(7143):407-12 [17522673] Int J Cancer. 2007 Aug 15;121(4):714-23 [17455256] Cancer Lett. 2008 Mar 18;261(2):183-92 [18160212] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Mol Carcinog. 2008 May;47(5):373-82 [17999388] Cancer Res. 2008 May 1;68(9):3193-203 [18451145] Oncogene. 2008 May 29;27(24):3384-92 [18193082] Oncogene. 1999 Nov 22;18(49):6938-47 [10602468] Mol Cell Biol. 2000 Jun;20(11):3807-16 [10805724] Gut. 2000 Jul;47(1):50-6 [10861264] Int J Cancer. 2000 Nov 1;88(3):417-23 [11054671] Biochem J. 2001 Aug 1;357(Pt 3):905-10 [11463365] Surgery. 2001 Aug;130(2):363-9 [11490372] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9671-6 [11481424] J Biol Chem. 2001 Nov 23;276(47):43653-62 [11544250] Int J Cancer. 2002 Jan 20;97(3):283-9 [11774278] Mol Cell Biol. 2002 Feb;22(3):835-48 [11784859] J Biol Chem. 2002 Feb 1;277(5):3247-57 [11714700] Nat Rev Cancer. 2002 Apr;2(4):301-10 [12001991] Crit Rev Biochem Mol Biol. 2002;37(3):149-66 [12139441] J Biol Chem. 2002 Aug 16;277(33):29832-9 [12015309] Nature. 2002 Sep 26;419(6905):407-11 [12353038] J Clin Pathol. 2002 Oct;55(10):758-62 [12354802] Int J Mol Med. 2002 Nov;10(5):547-50 [12373289] Trends Cell Biol. 2002 Nov;12(11):532-8 [12446115] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Gastric Cancer. 2003;6(1):30-8 [12673424] Oncology. 2003;65(1):37-45 [12837981] Cell. 2003 Jul 11;114(1):99-111 [12859901] Cell. 1994 Sep 9;78(5):773-85 [8087845] Nat Genet. 1996 Dec;14(4):415-20 [8944021] J Biol Chem. 1997 Jun 6;272(23):14914-20 [9169462] J Invest Dermatol. 1997 Aug;109(2):225-31 [9242512] Am J Pathol. 1997 Aug;151(2):499-508 [9250162] Nature. 1998 Jan 15;391(6664):295-8 [9440695] Matrix Biol. 1998 Mar;16(8):483-96 [9550265] Cytogenet Cell Genet. 1998;83(3-4):232-5 [10072587] APMIS. 1999 Jan;107(1):45-53 [10190279] Curr Opin Genet Dev. 1999 Apr;9(2):140-7 [10322133] Trends Biochem Sci. 2005 Jan;30(1):43-52 [15653325] Cell. 2005 Jan 28;120(2):169-81 [15680324] Int J Cancer. 2005 Jul 20;115(6):967-74 [15729715] FEBS Lett. 2005 May 23;579(13):2868-72 [15876433] Mol Cell Biol. 2005 Aug;25(15):6639-48 [16024799] Cancer Res. 2005 Nov 15;65(22):10255-64 [16288013] Pathol Res Pract. 2005;201(12):777-89 [16308103] J Clin Invest. 2003 Dec;112(12):1887-94 [14679184] Cell Death Differ. 2004 Jan;11(1):123-30 [14526390] J Biol Chem. 1994 Jun 17;269(24):16766-73 [8207000] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24437 ER - TY - JOUR T1 - ITM Probe: analyzing information flow in protein networks AN - 20938047; 11012006 AB - Summary: Founded upon diffusion with damping, ITM Probe is an application for modeling information flow in protein interaction networks without prior restriction to the sub-network of interest. Given a context consisting of desired origins and destinations of information, ITM Probe returns the set of most relevant proteins with weights and a graphical representation of the corresponding sub-network. With a click, the user may send the resulting protein list for enrichment analysis to facilitate hypothesis formation or confirmation.Availability: ITM Probe web service and documentation can be found at www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe. JF - Bioinformatics AU - Stojmirovic, Aleksandar AU - Yu, Yi-Kuo Y1 - 2009/09/15/ PY - 2009 DA - 2009 Sep 15 SP - 2447 EP - 2449 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 18 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Probes KW - Computer graphics KW - Diffusion KW - Bioinformatics KW - Manganese KW - Internet KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20938047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=ITM+Probe%3A+analyzing+information+flow+in+protein+networks&rft.au=Stojmirovic%2C+Aleksandar%3BYu%2C+Yi-Kuo&rft.aulast=Stojmirovic&rft.aufirst=Aleksandar&rft.date=2009-09-15&rft.volume=25&rft.issue=18&rft.spage=2447&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp398 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; Computer graphics; Probes; Diffusion; Bioinformatics; Manganese; Protein interaction; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btp398 ER - TY - CPAPER T1 - Strategies for Biomarker Selection T2 - 2007 World Congress on Medical Physics and Biomedical Engineering AN - 41102945; 4946001 JF - 2007 World Congress on Medical Physics and Biomedical Engineering AU - "Clarke, Laurence P. " AU - "Golubnitschaja, Olga " Y1 - 2009/09/13/ PY - 2009 DA - 2009 Sep 13 KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41102945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+World+Congress+on+Medical+Physics+and+Biomedical+Engineering&rft.atitle=Strategies+for+Biomarker+Selection&rft.au=%22Clarke%2C+Laurence+P.+%22%3B%22Golubnitschaja%2C+Olga+%22&rft.aulast=%22Clarke&rft.aufirst=Laurence+P.&rft.date=2009-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+World+Congress+on+Medical+Physics+and+Biomedical+Engineering&rft.issn=&rft_id=info:doi/ L2 - http://www.wc2009.org/world-congress-2009/programs/Pages/Scientific%20 Program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene expression. AN - 67636354; 19556237 AB - The transition metal cadmium is an environmental teratogen. In addition, cadmium and retinoic acid can act synergistically to induce forelimb malformations. The molecular mechanism underlying the teratogenicity of cadmium and the synergistic effect with retinoic acid has not been addressed. An evolutionarily conserved gene, beta,beta-carotene 15,15'-monooxygenase (BCMO), which is involved in retinoic acid biosynthesis, was studied in both Caenorhabditis elegans and murine Hepa 1-6 cells. In C. elegans, bcmo-1 was expressed in the intestine and was cadmium inducible. Similarly, in Hepa 1-6 cells, Bcmo1 was induced by cadmium. Retinoic acid-mediated signaling increased after 24-h exposures to 5 and 10 microm cadmium in Hepa 1-6 cells. Examination of gene expression demonstrated that the induction of retinoic acid signaling by cadmium may be mediated by overexpression of Bcmo1. Furthermore, cadmium inhibited the expression of Cyp26a1 and Cyp26b1, which are involved in retinoic acid degradation. These results indicate that cadmium-induced teratogenicity may be due to the ability of the metal to increase the levels of retinoic acid by disrupting the expression of retinoic acid-metabolizing genes. JF - The Journal of biological chemistry AU - Cui, Yuxia AU - Freedman, Jonathan H AD - Comparative Genomics Group, Laboratory of Molecular Toxicology, NIEHS, National Institutes of Health, Durham, North Carolina 27709, USA. Y1 - 2009/09/11/ PY - 2009 DA - 2009 Sep 11 SP - 24925 EP - 24932 VL - 284 IS - 37 KW - Cadmium KW - 00BH33GNGH KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Tretinoin KW - 5688UTC01R KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cyp26a1 protein, mouse KW - EC 1.14.14.1 KW - Cyp26b1 protein, mouse KW - Retinoic Acid 4-Hydroxylase KW - Bcmo1 protein, mouse KW - EC 1.14.99.36 KW - beta-Carotene 15,15'-Monooxygenase KW - Index Medicus KW - Animals KW - beta-Carotene 15,15'-Monooxygenase -- metabolism KW - Caenorhabditis elegans KW - Mice, Inbred C57BL KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Mice KW - Intestines -- metabolism KW - Animals, Genetically Modified KW - Time Factors KW - Models, Biological KW - Green Fluorescent Proteins -- metabolism KW - Cadmium -- metabolism KW - Tretinoin -- metabolism KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67636354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cadmium+induces+retinoic+acid+signaling+by+regulating+retinoic+acid+metabolic+gene+expression.&rft.au=Cui%2C+Yuxia%3BFreedman%2C+Jonathan+H&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2009-09-11&rft.volume=284&rft.issue=37&rft.spage=24925&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.026609 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-09-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Reprod Toxicol. 1990;4(4):291-304 [1726510] Funct Dev Morphol. 1991;1(2):3-9 [1790338] IARC Sci Publ. 1992;(118):249-56 [1303948] Toxicol Lett. 1995 Apr;76(3):195-202 [7762007] Anal Biochem. 1996 Oct 15;241(2):199-205 [8921188] Biochem Biophys Res Commun. 1998 Aug 19;249(2):467-74 [9712720] Neurotoxicology. 1998 Aug-Oct;19(4-5):529-35 [9745907] Teratology. 1999 Jul;60(1):13-21 [10413334] Reprod Toxicol. 2005 Mar-Apr;19(4):479-85 [15749261] Nature. 2005 Mar 24;434(7032):462-9 [15791247] Development. 2005 Jun;132(11):2611-22 [15872003] Arch Biochem Biophys. 2005 Jul 1;439(1):32-41 [15950170] Biometals. 2005 Jun;18(3):233-41 [15984568] J Biol Chem. 2005 Aug 12;280(32):29217-23 [15951442] Dev Biol. 2005 Sep 1;285(1):224-37 [16054125] Birth Defects Res A Clin Mol Teratol. 2006 Jan;76(1):19-28 [16369952] J Neurobiol. 2006 Jun;66(7):606-30 [16688755] BMC Mol Biol. 2006;7:7 [16504037] Eur J Nutr. 2006 Sep;45(6):320-6 [16699835] Dev Biol. 2007 Feb 15;302(2):627-45 [17113066] Mol Genet Metab. 2007 Nov;92(3):258-70 [17707671] Toxicol Appl Pharmacol. 2007 Nov 15;225(1):47-60 [17884124] PLoS Biol. 2007 Nov;5(11):e304 [18031199] Genome Biol. 2007;8(6):R122 [17592649] Dev Dyn. 2008 Oct;237(10):2775-90 [18816852] Genomics. 2000 Jan 15;63(2):193-201 [10673332] Physiol Rev. 2000 Jul;80(3):1021-54 [10893430] Br J Nutr. 2000 Jul;84(1):117-24 [10961168] J Biol Chem. 2001 Apr 27;276(17):14110-6 [11278918] Environ Toxicol Chem. 2001 Apr;20(4):833-8 [11345460] Teratology. 2001 Aug;64(2):87-97 [11460260] J Biol Chem. 2001 Aug 24;276(34):32160-8 [11418584] Reprod Toxicol. 2001 Nov-Dec;15(6):673-81 [11738520] Curr Top Med Chem. 2001 Dec;1(6):529-39 [11895129] Biotechniques. 2002 Apr;32(4):728-30 [11962590] Nat Genet. 2002 May;31(1):7-8 [11953747] Occup Environ Med. 2002 Jun;59(6):394-6; discussion 397 [12040115] Nature. 2003 Jan 16;421(6920):231-7 [12529635] Development. 2003 May;130(10):2173-86 [12668631] Gen Physiol Biophys. 2002 Dec;21(4):443-56 [12693715] FASEB J. 2003 Jul;17(10):1304-6 [12759335] J Nutr Sci Vitaminol (Tokyo). 2003 Feb;49(1):69-72 [12882399] J Occup Health. 2003 Nov;45(6):331-4 [14676411] J Nutr. 2004 Jan;134(1):246S-250S [14704328] Mech Dev. 2004 Apr;121(4):339-50 [15110044] Genome Res. 2004 Oct;14(10B):2162-8 [15489339] Teratology. 1979 Apr;19(2):229-35 [473073] Teratology. 1982 Feb;25(1):61-70 [7064112] Teratology. 1985 Dec;32(3):433-51 [4082072] Arch Toxicol. 1987 Apr;59(6):443-7 [3606391] Teratology. 1987 Oct;36(2):163-70 [3424202] Toxicology. 1990 Oct;64(1):89-104 [2219135] Fundam Appl Toxicol. 1991 Jan;16(1):22-3 [2019348] Cell. 1991 Jun 28;65(7):1255-66 [1648450] Crit Rev Toxicol. 1992;22(3-4):175-201 [1388705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.026609 ER - TY - JOUR T1 - Reemergence of PML in natalizumab-treated patients--new cases, same concerns. AN - 67644615; 19741226 JF - The New England journal of medicine AU - Major, Eugene O AD - Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Y1 - 2009/09/10/ PY - 2009 DA - 2009 Sep 10 SP - 1041 EP - 1043 VL - 361 IS - 11 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antigens, CD34 KW - Biomarkers KW - DNA, Viral KW - Natalizumab KW - Integrin alpha4 KW - 143198-26-9 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Urine -- virology KW - DNA, Viral -- blood KW - Antigens, CD34 -- blood KW - Biomarkers -- blood KW - Integrin alpha4 -- immunology KW - Virus Activation -- drug effects KW - Multiple Sclerosis -- complications KW - Multiple Sclerosis -- drug therapy KW - JC Virus -- physiology KW - JC Virus -- drug effects KW - Antibodies, Monoclonal -- adverse effects KW - JC Virus -- isolation & purification KW - Leukoencephalopathy, Progressive Multifocal -- chemically induced KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67644615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Reemergence+of+PML+in+natalizumab-treated+patients--new+cases%2C+same+concerns.&rft.au=Major%2C+Eugene+O&rft.aulast=Major&rft.aufirst=Eugene&rft.date=2009-09-10&rft.volume=361&rft.issue=11&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp0906248 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-21 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: N Engl J Med. 2009 Sep 10;361(11):1067-74 [19741227] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMp0906248 ER - TY - JOUR T1 - The nucleoside analogue D-carba T blocks HIV-1 reverse transcription. AN - 67629389; 19678643 AB - A major pathway for HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs) involves reverse transcriptase (RT) mutations that enhance ATP-dependent pyrophosphorolysis, which excises NRTIs from the end of viral DNA. We analyzed novel NRTIs for their ability to inhibit DNA synthesis of excision-proficient HIV-1 RT mutants. D-carba T is a carbocyclic nucleoside that has a 3' hydroxyl on the pseudosugar. The 3' hydroxyl group allows RT to incorporate additional dNTPs, which should protect D-carba TMP from excision. D-carba T can be converted to the triphosphate form by host cell kinases with moderate efficiency. D-carba T-TP is efficiently incorporated by HIV-1 RT; however, the next dNTP is added slowly to a D-carba TMP at the primer terminus. D-carba T effectively inhibits viral vectors that replicate using NRTI-resistant HIV-1 RTs, and there is no obvious toxicity in cultured cells. NRTIs based on the carbocyclic pseudosugar may offer an effective approach for the treatment of HIV-1 infections. JF - Journal of medicinal chemistry AU - Boyer, Paul L AU - Vu, B Christie AU - Ambrose, Zandrea AU - Julias, John G AU - Warnecke, Svenja AU - Liao, Chenzhong AU - Meier, Chris AU - Marquez, Victor E AU - Hughes, Stephen H AD - HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2009/09/10/ PY - 2009 DA - 2009 Sep 10 SP - 5356 EP - 5364 VL - 52 IS - 17 KW - Anti-HIV Agents KW - 0 KW - Pyrimidine Nucleosides KW - Reverse Transcriptase Inhibitors KW - carbathymidine KW - 114884-15-0 KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Base Sequence KW - Virus Replication -- drug effects KW - Models, Molecular KW - Humans KW - Cell Line, Tumor KW - Molecular Conformation KW - Anti-HIV Agents -- chemistry KW - Reverse Transcriptase Inhibitors -- chemistry KW - Thymidine -- chemistry KW - Reverse Transcriptase Inhibitors -- pharmacology KW - HIV Reverse Transcriptase -- antagonists & inhibitors KW - Anti-HIV Agents -- adverse effects KW - Pyrimidine Nucleosides -- pharmacology KW - HIV-1 -- enzymology KW - HIV-1 -- physiology KW - Thymidine -- pharmacology KW - Pyrimidine Nucleosides -- adverse effects KW - Thymidine -- adverse effects KW - Reverse Transcriptase Inhibitors -- adverse effects KW - Pyrimidine Nucleosides -- chemistry KW - Anti-HIV Agents -- pharmacology KW - HIV-1 -- drug effects KW - Thymidine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67629389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=The+nucleoside+analogue+D-carba+T+blocks+HIV-1+reverse+transcription.&rft.au=Boyer%2C+Paul+L%3BVu%2C+B+Christie%3BAmbrose%2C+Zandrea%3BJulias%2C+John+G%3BWarnecke%2C+Svenja%3BLiao%2C+Chenzhong%3BMeier%2C+Chris%3BMarquez%2C+Victor+E%3BHughes%2C+Stephen+H&rft.aulast=Boyer&rft.aufirst=Paul&rft.date=2009-09-10&rft.volume=52&rft.issue=17&rft.spage=5356&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm801176e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-09-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Front Biosci. 2004 Jan 1;9:873-90 [14766416] J Infect Dis. 2003 Oct 1;188(7):992-1000 [14513419] J Virol. 1979 Jun;30(3):942-5 [225551] J Biol Chem. 1979 Nov 10;254(21):10747-53 [227850] Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4 [7687065] Curr Opin Struct Biol. 2004 Dec;14(6):716-30 [15582396] J Mol Biol. 2005 Jan 21;345(3):441-50 [15581889] Antiviral Res. 2006 Sep;71(2-3):282-92 [16735066] J Mol Biol. 2007 Aug 24;371(4):873-82 [17597154] J Virol. 2008 Jan;82(2):719-27 [17989171] J Org Chem. 2009 Apr 17;74(8):3024-30 [19320463] J Am Chem Soc. 2004 Jan 21;126(2):543-9 [14719951] Curr Top Med Chem. 2002 Oct;2(10):1111-21 [12173970] Clin Ther. 2002 Oct;24(10):1515-48 [12462284] Virology. 2004 Apr 25;322(1):13-21 [15063112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm801176e ER - TY - CPAPER T1 - Neuronal Pentraxin 1 contributes to the descending modulation of neuropathic pain T2 - 6th Triennial Congress of the European Federation of Chapters of the International Association for the Study of Pain (Pain In Europe VI) AN - 42556036; 5471037 JF - 6th Triennial Congress of the European Federation of Chapters of the International Association for the Study of Pain (Pain In Europe VI) AU - Zapata, A AU - Schepers, R AU - Gehrke, B AU - Oh, E AU - Trullas, R AU - Shippenberg, T Y1 - 2009/09/09/ PY - 2009 DA - 2009 Sep 09 KW - Pain KW - Neuropathy KW - Neuromodulation KW - Pentraxins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42556036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Triennial+Congress+of+the+European+Federation+of+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28Pain+In+Europe+VI%29&rft.atitle=Neuronal+Pentraxin+1+contributes+to+the+descending+modulation+of+neuropathic+pain&rft.au=Zapata%2C+A%3BSchepers%2C+R%3BGehrke%2C+B%3BOh%2C+E%3BTrullas%2C+R%3BShippenberg%2C+T&rft.aulast=Zapata&rft.aufirst=A&rft.date=2009-09-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Triennial+Congress+of+the+European+Federation+of+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28Pain+In+Europe+VI%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.kenes.com/efic/Pages/program_poster1.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sickle cell disease selectively decreases mouse current vocalization thresholds in Adelta and C-fiber but not Abeta fibers T2 - 6th Congress of the European Federation of the Chapters of the International Association for the Study of Pain (EFIC 2009) AN - 41997200; 5334666 JF - 6th Congress of the European Federation of the Chapters of the International Association for the Study of Pain (EFIC 2009) AU - Besch, V AU - Middleton, L AU - Khaibullina, A AU - Quezado, Z AU - Finkel, J Y1 - 2009/09/09/ PY - 2009 DA - 2009 Sep 09 KW - Volatile organic compounds KW - Fibers KW - Sickle cell disease KW - Vocalization behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41997200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Congress+of+the+European+Federation+of+the+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28EFIC+2009%29&rft.atitle=Sickle+cell+disease+selectively+decreases+mouse+current+vocalization+thresholds+in+Adelta+and+C-fiber+but+not+Abeta+fibers&rft.au=Besch%2C+V%3BMiddleton%2C+L%3BKhaibullina%2C+A%3BQuezado%2C+Z%3BFinkel%2C+J&rft.aulast=Besch&rft.aufirst=V&rft.date=2009-09-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Congress+of+the+European+Federation+of+the+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28EFIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.kenes.com/efic/Pages/program_friday.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A neuro-specific nociceptive assay can be used to measure effects of analgesics and sex in pain thresholds in mice T2 - 6th Congress of the European Federation of the Chapters of the International Association for the Study of Pain (EFIC 2009) AN - 41988066; 5334668 JF - 6th Congress of the European Federation of the Chapters of the International Association for the Study of Pain (EFIC 2009) AU - Besch, V AU - Khaibullina, A AU - Middleton, L AU - Quezado, Z AU - Finkel, J Y1 - 2009/09/09/ PY - 2009 DA - 2009 Sep 09 KW - Pain perception KW - Mice KW - Sex KW - Analgesics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41988066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Congress+of+the+European+Federation+of+the+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28EFIC+2009%29&rft.atitle=A+neuro-specific+nociceptive+assay+can+be+used+to+measure+effects+of+analgesics+and+sex+in+pain+thresholds+in+mice&rft.au=Besch%2C+V%3BKhaibullina%2C+A%3BMiddleton%2C+L%3BQuezado%2C+Z%3BFinkel%2C+J&rft.aulast=Besch&rft.aufirst=V&rft.date=2009-09-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Congress+of+the+European+Federation+of+the+Chapters+of+the+International+Association+for+the+Study+of+Pain+%28EFIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.kenes.com/efic/Pages/program_friday.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. AN - 67675903; 19737401 AB - The Human Immunodeficiency virus type 1 (HIV-1) Vpu protein enhances virus release from infected cells and induces proteasomal degradation of CD4. Recent work identified BST-2/CD317 as a host factor that inhibits HIV-1 virus release in a Vpu sensitive manner. A current working model proposes that BST-2 inhibits virus release by tethering viral particles to the cell surface thereby triggering their subsequent endocytosis. Here we defined structural properties of BST-2 required for inhibition of virus release and for sensitivity to Vpu. We found that BST-2 is modified by N-linked glycosylation at two sites in the extracellular domain. However, N-linked glycosylation was not important for inhibition of HIV-1 virus release nor did it affect surface expression or sensitivity to Vpu. Rodent BST-2 was previously found to form cysteine-linked dimers. Analysis of single, double, or triple cysteine mutants revealed that any one of three cysteine residues present in the BST-2 extracellular domain was sufficient for BST-2 dimerization, for inhibition of virus release, and sensitivity to Vpu. In contrast, BST-2 lacking all three cysteines in its ectodomain was unable to inhibit release of wild type or Vpu-deficient HIV-1 virions. This defect was not caused by a gross defect in BST-2 trafficking as the mutant protein was expressed at the cell surface of transfected 293T cells and was down-modulated by Vpu similar to wild type BST-2. While BST-2 glycosylation was functionally irrelevant, formation of cysteine-linked dimers appeared to be important for inhibition of virus release. However lack of dimerization did not prevent surface expression or Vpu sensitivity of BST-2, suggesting Vpu sensitivity and inhibition of virus release are separable properties of BST-2. JF - Retrovirology AU - Andrew, Amy J AU - Miyagi, Eri AU - Kao, Sandra AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460, USA. andrewa@niaid.nih.gov Y1 - 2009/09/08/ PY - 2009 DA - 2009 Sep 08 SP - 80 VL - 6 KW - Antigens, CD KW - 0 KW - BST2 protein, human KW - Disulfides KW - GPI-Linked Proteins KW - Human Immunodeficiency Virus Proteins KW - Membrane Glycoproteins KW - Viral Regulatory and Accessory Proteins KW - vpu protein, Human immunodeficiency virus 1 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Amino Acid Substitution -- genetics KW - Humans KW - Dimerization KW - Cysteine -- genetics KW - Cell Membrane -- chemistry KW - Glycosylation KW - Cell Line KW - Virus Replication KW - HIV-1 -- immunology KW - Viral Regulatory and Accessory Proteins -- physiology KW - Membrane Glycoproteins -- antagonists & inhibitors KW - Antigens, CD -- metabolism KW - HIV-1 -- physiology KW - Membrane Glycoproteins -- immunology KW - Human Immunodeficiency Virus Proteins -- physiology KW - Antigens, CD -- immunology KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67675903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retrovirology&rft.atitle=The+formation+of+cysteine-linked+dimers+of+BST-2%2Ftetherin+is+important+for+inhibition+of+HIV-1+virus+release+but+not+for+sensitivity+to+Vpu.&rft.au=Andrew%2C+Amy+J%3BMiyagi%2C+Eri%3BKao%2C+Sandra%3BStrebel%2C+Klaus&rft.aulast=Andrew&rft.aufirst=Amy&rft.date=2009-09-08&rft.volume=6&rft.issue=&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Retrovirology&rft.issn=1742-4690&rft_id=info:doi/10.1186%2F1742-4690-6-80 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-16 N1 - Date created - 2009-09-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1986 Aug;59(2):284-91 [3016298] J Virol. 1996 Feb;70(2):809-19 [8551619] Science. 1988 Sep 2;241(4870):1221-3 [3261888] Proc Natl Acad Sci U S A. 1989 Jul;86(13):5163-7 [2472639] J Virol. 1989 Sep;63(9):3784-91 [2788224] Anal Biochem. 1989 Aug 1;180(2):195-204 [2510544] J Virol. 1990 Feb;64(2):621-9 [2404139] J Biol Chem. 1990 Nov 25;265(33):20488-95 [2243102] J Virol. 1992 Jan;66(1):226-34 [1727486] J Virol. 1992 Aug;66(8):5119-26 [1629967] J Virol. 1992 Dec;66(12):7193-200 [1433512] J Virol. 1993 Jul;67(7):4190-4 [8510220] J Virol. 1993 Aug;67(8):5056-61 [8331740] J Mol Biol. 1994 Feb 11;236(1):16-25 [8107101] J Virol. 1996 Oct;70(10):7108-15 [8794357] FEBS Lett. 1996 Nov 25;398(1):12-8 [8946945] J Virol. 1998 Feb;72(2):1270-9 [9445027] J Virol. 1998 Jun;72(6):5189-97 [9573291] Biochem Biophys Res Commun. 1999 May 19;258(3):583-91 [10329429] Virology. 2005 Aug 15;339(1):56-69 [15975620] PLoS Pathog. 2006 May;2(5):e39 [16699598] PLoS Pathog. 2006 Oct;2(10):e107 [17238276] Cell Host Microbe. 2007 Sep 13;2(3):193-203 [18005734] Nature. 2008 Jan 24;451(7177):425-30 [18200009] Cell Host Microbe. 2008 Apr 17;3(4):245-52 [18342597] Nat Med. 2008 Jun;14(6):641-7 [18500349] J Virol. 2009 Mar;83(5):2382-5 [19091864] PLoS Pathog. 2009 Feb;5(2):e1000300 [19214216] Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2886-91 [19179289] Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2868-73 [19196977] Cell Host Microbe. 2009 Mar 19;5(3):285-97 [19286137] J Virol. 2009 May;83(9):4574-90 [19244337] PLoS Pathog. 2009 May;5(5):e1000443 [19461879] PLoS Pathog. 2009 May;5(5):e1000450 [19478868] J Virol. 2009 Aug;83(15):7536-46 [19474106] J Virol. 2009 Aug;83(16):7931-47 [19515779] J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):10-22 [8548340] J Biol Chem. 1999 Nov 19;274(47):33800-6 [10559275] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14336-41 [10588706] Virus Res. 2000 Feb;66(2):187-96 [10725551] Protein Sci. 2002 Mar;11(3):546-57 [11847278] Traffic. 2003 Oct;4(10):694-709 [12956872] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15154-9 [14657387] Virology. 2004 Feb 20;319(2):163-75 [15015498] Mol Cell. 2004 Apr 23;14(2):259-67 [15099524] Biochim Biophys Acta. 1975 Apr 7;385(2):305-11 [1092358] Cancer Res. 1982 Jul;42(7):2884-93 [6952958] Annu Rev Biochem. 1985;54:631-64 [3896128] J Virol. 1994 Apr;68(4):2260-71 [8139011] Blood. 1994 Sep 15;84(6):1922-30 [8080996] Genomics. 1995 Apr 10;26(3):527-34 [7607676] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):111-5 [8552585] Nature. 1988 Aug 11;334(6182):532-4 [3043230] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-4690-6-80 ER - TY - CPAPER T1 - Muscle-specific HA-GLUT4-GFP Transgenic Mouse: Fundamental Role of GLUT4 Hubs in the Regulation of Glucose Transport in Muscle T2 - Glucos Transporter Biology AN - 42371937; 5376842 JF - Glucos Transporter Biology AU - Lizunov, Vlad Y1 - 2009/09/06/ PY - 2009 DA - 2009 Sep 06 KW - Muscles KW - Glucose transport KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Glucos+Transporter+Biology&rft.atitle=Muscle-specific+HA-GLUT4-GFP+Transgenic+Mouse%3A+Fundamental+Role+of+GLUT4+Hubs+in+the+Regulation+of+Glucose+Transport+in+Muscle&rft.au=Lizunov%2C+Vlad&rft.aulast=Lizunov&rft.aufirst=Vlad&rft.date=2009-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Glucos+Transporter+Biology&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11806.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clustering of GLUT4 Molecules in the Plasma Membrane of Primary Adipose Cells as a Key Recycling Intermediate T2 - Glucos Transporter Biology AN - 42371910; 5376840 JF - Glucos Transporter Biology AU - Stenkula, Karin Y1 - 2009/09/06/ PY - 2009 DA - 2009 Sep 06 KW - Recycling KW - Waste management KW - Plasma membranes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Glucos+Transporter+Biology&rft.atitle=Clustering+of+GLUT4+Molecules+in+the+Plasma+Membrane+of+Primary+Adipose+Cells+as+a+Key+Recycling+Intermediate&rft.au=Stenkula%2C+Karin&rft.aulast=Stenkula&rft.aufirst=Karin&rft.date=2009-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Glucos+Transporter+Biology&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11806.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of glutamate receptors: Trafficking and phosphorylation T2 - 2009 Gordon Research Conference on Excitatory Synapses & Brain Function AN - 42367994; 5377262 JF - 2009 Gordon Research Conference on Excitatory Synapses & Brain Function AU - Roche, Katherine Y1 - 2009/09/06/ PY - 2009 DA - 2009 Sep 06 KW - Trafficking KW - Glutamic acid receptors KW - Protein transport KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42367994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Excitatory+Synapses+%26+Brain+Function&rft.atitle=Regulation+of+glutamate+receptors%3A+Trafficking+and+phosphorylation&rft.au=Roche%2C+Katherine&rft.aulast=Roche&rft.aufirst=Katherine&rft.date=2009-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Excitatory+Synapses+%26+Brain+Function&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=excitsynap LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. AN - 67636198; 19730409 AB - This report updates and combines into one document earlier versions of guidelines for preventing and treating opportunistic infections (OIs) among HIV-exposed and HIV-infected children, last published in 2002 and 2004, respectively. These guidelines are intended for use by clinicians and other health-care workers providing medical care for HIV-exposed and HIV-infected children in the United States. The guidelines discuss opportunistic pathogens that occur in the United States and one that might be acquired during international travel (i.e., malaria). Topic areas covered for each OI include a brief description of the epidemiology, clinical presentation, and diagnosis of the OI in children; prevention of exposure; prevention of disease by chemoprophylaxis and/or vaccination; discontinuation of primary prophylaxis after immune reconstitution; treatment of disease; monitoring for adverse effects during treatment; management of treatment failure; prevention of disease recurrence; and discontinuation of secondary prophylaxis after immune reconstitution. A separate document about preventing and treating of OIs among HIV-infected adults and postpubertal adolescents (Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents) was prepared by a working group of adult HIV and infectious disease specialists. The guidelines were developed by a panel of specialists in pediatric HIV infection and infectious diseases (the Pediatric Opportunistic Infections Working Group) from the U.S. government and academic institutions. For each OI, a pediatric specialist with content-matter expertise reviewed the literature for new information since the last guidelines were published; they then proposed revised recommendations at a meeting at the National Institutes of Health (NIH) in June 2007. After these presentations and discussions, the guidelines underwent further revision, with review and approval by the Working Group, and final endorsement by NIH, CDC, the HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA), the Pediatric Infectious Disease Society (PIDS), and the American Academy of Pediatrics (AAP). The recommendations are rated by a letter that indicates the strength of the recommendation and a Roman numeral that indicates the quality of the evidence supporting the recommendation so readers can ascertain how best to apply the recommendations in their practice environments. An important mode of acquisition of OIs, as well as HIV infection among children, is from their infected mother; HIV-infected women coinfected with opportunistic pathogens might be more likely than women without HIV infection to transmit these infections to their infants. In addition, HIV-infected women or HIV-infected family members coinfected with certain opportunistic pathogens might be more likely to transmit these infections horizontally to their children, resulting in increased likelihood of primary acquisition of such infections in the young child. Therefore, infections with opportunistic pathogens might affect not just HIV-infected infants but also HIV-exposed but uninfected infants who become infected by the pathogen because of transmission from HIV-infected mothers or family members with coinfections. These guidelines for treating OIs in children therefore consider treatment of infections among all children, both HIV-infected and uninfected, born to HIV-infected women. Additionally, HIV infection is increasingly seen among adolescents with perinatal infection now surviving into their teens and among youth with behaviorally acquired HIV infection. Although guidelines for postpubertal adolescents can be found in the adult OI guidelines, drug pharmacokinetics and response to treatment may differ for younger prepubertal or pubertal adolescents. Therefore, these guidelines also apply to treatment of HIV-infected youth who have not yet completed pubertal development. Major changes in the guidelines include 1) greater emphasis on the importance of antiretroviral therapy for preventing and treating OIs, especially those OIs for which no specific therapy exists; 2) information about the diagnosis and management of immune reconstitution inflammatory syndromes; 3) information about managing antiretroviral therapy in children with OIs, including potential drug--drug interactions; 4) new guidance on diagnosing of HIV infection and presumptively excluding HIV infection in infants that affect the need for initiation of prophylaxis to prevent Pneumocystis jirovecii pneumonia (PCP) in neonates; 5) updated immunization recommendations for HIV-exposed and HIV-infected children, including hepatitis A, human papillomavirus, meningococcal, and rotavirus vaccines; 6) addition of sections on aspergillosis; bartonella; human herpes virus-6, -7, and -8; malaria; and progressive multifocal leukodystrophy (PML); and 7) new recommendations on discontinuation of OI prophylaxis after immune reconstitution in children. The report includes six tables pertinent to preventing and treating OIs in children and two figures describing immunization recommendations for children aged 0--6 years and 7--18 years. Because treatment of OIs is an evolving science, and availability of new agents or clinical data on existing agents might change therapeutic options and preferences, these recommendations will be periodically updated and will be available at http://AIDSInfo.nih.gov. JF - MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports AU - Mofenson, Lynne M AU - Brady, Michael T AU - Danner, Susie P AU - Dominguez, Kenneth L AU - Hazra, Rohan AU - Handelsman, Edward AU - Havens, Peter AU - Nesheim, Steve AU - Read, Jennifer S AU - Serchuck, Leslie AU - Van Dyke, Russell AU - Centers for Disease Control and Prevention AU - National Institutes of Health AU - HIV Medicine Association of the Infectious Diseases Society of America AU - Pediatric Infectious Diseases Society AU - American Academy of Pediatrics AD - National Institutes of Health, Bethesda, Maryland, USA. ; Centers for Disease Control and Prevention ; National Institutes of Health ; HIV Medicine Association of the Infectious Diseases Society of America ; Pediatric Infectious Diseases Society ; American Academy of Pediatrics Y1 - 2009/09/04/ PY - 2009 DA - 2009 Sep 04 SP - 1 EP - 166 VL - 58 KW - Anti-Retroviral Agents KW - 0 KW - Index Medicus KW - Treatment Failure KW - Humans KW - Infant, Newborn KW - Child KW - Immunization Schedule KW - Recurrence KW - Pregnancy KW - Child, Preschool KW - Infant KW - Immune Reconstitution Inflammatory Syndrome -- drug therapy KW - Adult KW - Immune Reconstitution Inflammatory Syndrome -- diagnosis KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - AIDS-Related Opportunistic Infections -- drug therapy KW - HIV Infections -- transmission KW - HIV Infections -- complications KW - Anti-Retroviral Agents -- adverse effects KW - AIDS-Related Opportunistic Infections -- prevention & control KW - AIDS-Related Opportunistic Infections -- diagnosis KW - AIDS-Related Opportunistic Infections -- epidemiology KW - HIV Infections -- diagnosis KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67636198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.atitle=Guidelines+for+the+Prevention+and+Treatment+of+Opportunistic+Infections+among+HIV-exposed+and+HIV-infected+children%3A+recommendations+from+CDC%2C+the+National+Institutes+of+Health%2C+the+HIV+Medicine+Association+of+the+Infectious+Diseases+Society+of+America%2C+the+Pediatric+Infectious+Diseases+Society%2C+and+the+American+Academy+of+Pediatrics.&rft.au=Mofenson%2C+Lynne+M%3BBrady%2C+Michael+T%3BDanner%2C+Susie+P%3BDominguez%2C+Kenneth+L%3BHazra%2C+Rohan%3BHandelsman%2C+Edward%3BHavens%2C+Peter%3BNesheim%2C+Steve%3BRead%2C+Jennifer+S%3BSerchuck%2C+Leslie%3BVan+Dyke%2C+Russell%3BCenters+for+Disease+Control+and+Prevention%3BNational+Institutes+of+Health%3BHIV+Medicine+Association+of+the+Infectious+Diseases+Society+of+America%3BPediatric+Infectious+Diseases+Society%3BAmerican+Academy+of+Pediatrics&rft.aulast=Mofenson&rft.aufirst=Lynne&rft.date=2009-09-04&rft.volume=58&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.issn=1545-8601&rft_id=info:doi/ 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2017-01-18 ER - TY - CPAPER T1 - Immune cell-related MICRORNA-155 is associated with human liver cirrhosis and hepatocellular carcinoma T2 - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AN - 42375491; 5369751 JF - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AU - Budhu, Anuradha AU - Yu, Zhipeng AU - Forgues, Marshonna AU - Tang, Zhao-You AU - Croce, Carlo AU - Wang, Xin Y1 - 2009/09/04/ PY - 2009 DA - 2009 Sep 04 KW - Liver KW - Hepatocellular carcinoma KW - Cirrhosis KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42375491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.atitle=Immune+cell-related+MICRORNA-155+is+associated+with+human+liver+cirrhosis+and+hepatocellular+carcinoma&rft.au=Budhu%2C+Anuradha%3BYu%2C+Zhipeng%3BForgues%2C+Marshonna%3BTang%2C+Zhao-You%3BCroce%2C+Carlo%3BWang%2C+Xin&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2009-09-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ilca-online.org/sitecore/content/be-bruga/ilca-online/Annua l%20Conferences/2009/programme2009.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - c-Met is required for stem cell-mediated liver regeneration T2 - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AN - 42371786; 5369754 JF - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AU - Factor, Valentina AU - Ishikawa, Tsuyoshi AU - Marquardt, Jens AU - Raggi, Chiara AU - Conner, Elizabeth AU - Thorgeirsson, Snorri Y1 - 2009/09/04/ PY - 2009 DA - 2009 Sep 04 KW - Regeneration KW - Liver KW - Hepatocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.atitle=c-Met+is+required+for+stem+cell-mediated+liver+regeneration&rft.au=Factor%2C+Valentina%3BIshikawa%2C+Tsuyoshi%3BMarquardt%2C+Jens%3BRaggi%2C+Chiara%3BConner%2C+Elizabeth%3BThorgeirsson%2C+Snorri&rft.aulast=Factor&rft.aufirst=Valentina&rft.date=2009-09-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ilca-online.org/sitecore/content/be-bruga/ilca-online/Annua l%20Conferences/2009/programme2009.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic and epigenetic based prediction of response to zebularine therapy in human liver cancer T2 - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AN - 42365615; 5369769 JF - Third Annual Conference of the International Liver Cancer Association (ILCA 2009) AU - Andersen, Jesper AU - Raggi, Chiara AU - Marquardt, Jens AU - Conner, Elisabeth AU - Lee, Yun-Han AU - Factor, Valentina AU - Thorgeirsson, Snorri Y1 - 2009/09/04/ PY - 2009 DA - 2009 Sep 04 KW - Liver cancer KW - Epigenetics KW - Genomics KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42365615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.atitle=Genomic+and+epigenetic+based+prediction+of+response+to+zebularine+therapy+in+human+liver+cancer&rft.au=Andersen%2C+Jesper%3BRaggi%2C+Chiara%3BMarquardt%2C+Jens%3BConner%2C+Elisabeth%3BLee%2C+Yun-Han%3BFactor%2C+Valentina%3BThorgeirsson%2C+Snorri&rft.aulast=Andersen&rft.aufirst=Jesper&rft.date=2009-09-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+Annual+Conference+of+the+International+Liver+Cancer+Association+%28ILCA+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ilca-online.org/sitecore/content/be-bruga/ilca-online/Annua l%20Conferences/2009/programme2009.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging AN - 21078762; 11073230 AB - Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences of persistent expressing Wnt1 in an epidermal compartment that includes the epithelial stem cells. Surprisingly, Wnt caused the rapid growth of the hair follicles, but this was followed by epithelial cell senescence, disappearance of the epidermal stem cell compartment, and progressive hair loss. Although Wnt1 induced the activation of beta -catenin and the mTOR pathway, both hair follicle hyperproliferation and stem cell exhaustion were strictly dependent on mTOR function. These findings suggest that whereas activation of beta - catenin contributes to tumor growth, epithelial stem cells may be endowed with a protective mechanism that results in cell senescence upon the persistent stimulation of proliferative pathways that activate mTOR, ultimately suppressing tumor formation. JF - Cell Stem Cell AU - Castilho, Rogerio M AU - Squarize, Cristiane H AU - Chodosh, Lewis A AU - Williams, Bart O AU - Gutkind, JSilvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, sg39v@nih.gov Y1 - 2009/09/04/ PY - 2009 DA - 2009 Sep 04 SP - 279 EP - 289 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 5 IS - 3 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Wnt protein KW - Follicles KW - Aging KW - Life span KW - Tumors KW - Hair KW - Embryogenesis KW - Stem cells KW - catenin KW - Senescence KW - Signal transduction KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21078762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=mTOR+Mediates+Wnt-Induced+Epidermal+Stem+Cell+Exhaustion+and+Aging&rft.au=Castilho%2C+Rogerio+M%3BSquarize%2C+Cristiane+H%3BChodosh%2C+Lewis+A%3BWilliams%2C+Bart+O%3BGutkind%2C+JSilvio&rft.aulast=Castilho&rft.aufirst=Rogerio&rft.date=2009-09-04&rft.volume=5&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2009.06.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stem cells; Wnt protein; Hair; Senescence; Follicles; Tumors; catenin; Life span; Signal transduction; Aging; Epithelial cells; Embryogenesis DO - http://dx.doi.org/10.1016/j.stem.2009.06.017 ER - TY - JOUR T1 - Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells. AN - 67632719; 19581934 AB - Previous studies have described one nuclear localization signal (NLSI) in p53 and speculated on two additional sites termed NLSII and NLSIII. Drug-resistant KB cells selected with cisplatin or oxaliplatin were found to have increased p53 levels and in oxaliplatin-selected cells, a larger p53 predominantly in the cytoplasm. In oxaliplatin-selected cells a single nucleotide deletion in the sequence-encoding amino acid 382, part of NLSIII, resulted in a frame shift and a 420 amino acid protein (p53(420)). We investigated explanations for the cytoplasmic sequestration of p53(420) while assessing the role, if any, of NLSII and NLSIII in p53 nuclear import. We found that neither NLSII nor NLSIII are essential for p53 nuclear localization. Furthermore, we confirmed p53(420) is able to tetramerize, transactivate a p21 promoter, bind dynein and that the reduced nuclear accumulation is not a consequence of increased p53 nuclear export. However, the association of p53(420) with importin-beta, essential for nuclear import, was significantly impaired. We conclude that despite sequence similarity to consensus NLSs neither NLSII nor NLSIII have roles in p53 nuclear transport. We also identified impaired association with importin as a novel mechanism of p53 cytoplasmic sequestration that impairs nuclear transport rendering cells functionally deficient in p53. JF - Oncogene AU - Komlodi-Pasztor, E AU - Trostel, S AU - Sackett, D AU - Poruchynsky, M AU - Fojo, T AD - Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. komlodie@mail.nih.gov Y1 - 2009/09/03/ PY - 2009 DA - 2009 Sep 03 SP - 3111 EP - 3120 VL - 28 IS - 35 KW - Antineoplastic Agents KW - 0 KW - Nuclear Proteins KW - Organoplatinum Compounds KW - Tumor Suppressor Protein p53 KW - beta Karyopherins KW - oxaliplatin KW - 04ZR38536J KW - Index Medicus KW - Frameshift Mutation KW - KB Cells KW - Cytoplasm -- metabolism KW - Cell Nucleus -- metabolism KW - Humans KW - Protein Binding -- genetics KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Nuclear Proteins -- metabolism KW - Biological Transport, Active KW - Mutation KW - Organoplatinum Compounds -- pharmacology KW - beta Karyopherins -- metabolism KW - beta Karyopherins -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Antineoplastic Agents -- pharmacology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67632719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Impaired+p53+binding+to+importin%3A+a+novel+mechanism+of+cytoplasmic+sequestration+identified+in+oxaliplatin-resistant+cells.&rft.au=Komlodi-Pasztor%2C+E%3BTrostel%2C+S%3BSackett%2C+D%3BPoruchynsky%2C+M%3BFojo%2C+T&rft.aulast=Komlodi-Pasztor&rft.aufirst=E&rft.date=2009-09-03&rft.volume=28&rft.issue=35&rft.spage=3111&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2009.166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-09-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2007 Dec 13;26(57):7885-93 [17599045] Adv Exp Med Biol. 2007;608:70-86 [17993233] J Biol Chem. 2000 Jul 28;275(30):23139-45 [10930427] Carcinogenesis. 2000 Sep;21(9):1631-8 [10964093] Nat Cell Biol. 2000 Oct;2(10):709-17 [11025661] Exp Cell Res. 2001 Mar 10;264(1):56-66 [11237523] Curr Opin Cell Biol. 2001 Jun;13(3):332-7 [11343904] Neuro Oncol. 2002 Jul;4(3):171-8 [12084347] Cancer Invest. 2002;20(4):509-17 [12094546] Oncogene. 2003 May 15;22(19):2960-6 [12771947] Drug Resist Updat. 2003 Dec;6(6):313-22 [14744495] Genes Dev. 2004 Feb 1;18(3):261-77 [14744935] Proc R Soc Lond B Biol Sci. 1985 Oct 22;226(1242):43-58 [2866523] EMBO J. 1987 Jan;6(1):69-74 [2884102] J Biol Chem. 1989 Oct 25;264(30):18019-23 [2553699] Mol Cell Biol. 1990 Dec;10(12):6565-77 [2247074] Nature. 1991 Jun 6;351(6326):453-6 [2046748] Science. 1991 Jul 5;253(5015):49-53 [1905840] Oncogene. 1991 Nov;6(11):2055-65 [1719467] Nature. 1992 Jul 2;358(6381):15-6 [1614522] Lancet. 1992 Dec 5;340(8832):1369-73 [1360088] Cancer Res. 1993 Sep 1;53(17):4053-8 [8358734] J Natl Cancer Inst. 1994 May 4;86(9):681-7 [8158699] Proc Natl Acad Sci U S A. 1995 May 9;92(10):4407-11 [7753819] Br J Dermatol. 1995 Jul;133(1):23-31 [7669636] Am J Pathol. 1995 Sep;147(3):790-8 [7677190] EMBO J. 1998 Jan 15;17(2):554-64 [9430646] Mol Cell Biol. 1998 Dec;18(12):7288-93 [9819415] EMBO J. 1999 Mar 15;18(6):1660-72 [10075936] Semin Cancer Biol. 1998;8(5):345-57 [10101800] J Cell Biol. 2005 Mar 28;168(7):1027-38 [15795315] Oncology. 2005;69(2):154-8 [16127286] J Cell Sci. 2006 Jun 15;119(Pt 12):2457-67 [16720642] Cell Cycle. 2006 Oct;5(19):2253-9 [16969106] Cell Death Differ. 2007 Jul;14(7):1350-60 [17380154] J Biol Chem. 1999 Nov 12;274(46):32699-703 [10551826] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2009.166 ER - TY - JOUR T1 - Efficient Delivery of Antisense Oligodeoxyribonucleotide G3139 by Human Serum Albumin-Coated Liposomes AN - 754550389; 13305409 AB - Human serum albumin (HSA)-coated liposomal formulations were synthesized and evaluated for the delivery of antisense oligodeoxyribonucleotide (ODN) G3139 in KB human oral carcinoma cells. Liposomes composed of dimethyldioctadecyl ammonium bromide/egg phosphatidylcholine/*a-tocopheryl polyethylene glycol 1000 succinate (58:40:2 molar ratio) complexed with G3139 and coated with HSA were investigated for Bcl-2 downregulating activity. Cellular uptake of HSA-coated liposome-ODN complexes was more efficient than the uncoated liposome-ODN complexes. Treatment of the cells with HSA-coated liposome-ODN complexes resulted in efficient Bcl-2 mRNA downregulation that was approximately 3-fold greater than with uncoated liposomes (p < 0.05) and 6-fold greater than with free ODN. The transfection efficiency of liposome-ODN complexes coated with HSA was dependent on the concentration of HSA used and on the contents of *a-helix and *b-strand in HSA. HSA-coated liposomes are effective delivery vehicles for antisense ODN. JF - Molecular Pharmaceutics AU - Weecharangsan, Wanlop AU - Yu, Bo AU - Zheng, Yu AU - Liu, Shujun AU - Pang, Jiu Xia AU - Lee, L James AU - Marcucci, Guido AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, Thailand, Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, Ohio, Division of Hematology and Oncology, The Ohio State University, Columbus, Ohio, and NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), The Ohio State University, Columbus, Ohio Y1 - 2009/09/02/ PY - 2009 DA - 2009 Sep 02 SP - 1848 EP - 1855 PB - American Chemical Society VL - 6 IS - 6 SN - 1543-8384, 1543-8384 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Ammonium KW - Lecithin KW - human serum albumin KW - bromides KW - Oligonucleotides KW - Liposomes KW - mRNA KW - Antisense oligonucleotides KW - Antisense KW - oral carcinoma KW - Transfection KW - Bcl-2 protein KW - Polyethylene glycol KW - N 14830:RNA KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754550389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Efficient+Delivery+of+Antisense+Oligodeoxyribonucleotide+G3139+by+Human+Serum+Albumin-Coated+Liposomes&rft.au=Weecharangsan%2C+Wanlop%3BYu%2C+Bo%3BZheng%2C+Yu%3BLiu%2C+Shujun%3BPang%2C+Jiu+Xia%3BLee%2C+L+James%3BMarcucci%2C+Guido%3BLee%2C+Robert+J&rft.aulast=Weecharangsan&rft.aufirst=Wanlop&rft.date=2009-09-02&rft.volume=6&rft.issue=6&rft.spage=1848&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp900150g LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Ammonium; Lecithin; human serum albumin; bromides; Liposomes; Oligonucleotides; mRNA; Antisense oligonucleotides; Antisense; Transfection; oral carcinoma; Bcl-2 protein; Polyethylene glycol DO - http://dx.doi.org/10.1021/mp900150g ER - TY - JOUR T1 - Ionic Liquid Mediated Synthesis of 5-Halouracil Nucleosides: Key Precursors for Potential Antiviral Drugs AN - 918046391; 14320931 AB - Abstract not available. JF - Nucleosides, Nucleotides & Nucleic Acids AU - Kumar, Vineet AU - Malhotra, Sanjay V AD - Laboratory of Synthetic Chemistry, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 821 EP - 834 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 28 IS - 9 SN - 1525-7770, 1525-7770 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Antiviral agents KW - nucleosides KW - Nucleotides KW - A 01340:Antibiotics & Antimicrobials KW - N 14840:Antisense, Nucleotide Analogs KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918046391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleosides%2C+Nucleotides+%26+Nucleic+Acids&rft.atitle=Ionic+Liquid+Mediated+Synthesis+of+5-Halouracil+Nucleosides%3A+Key+Precursors+for+Potential+Antiviral+Drugs&rft.au=Kumar%2C+Vineet%3BMalhotra%2C+Sanjay+V&rft.aulast=Kumar&rft.aufirst=Vineet&rft.date=2009-09-01&rft.volume=28&rft.issue=9&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Nucleosides%2C+Nucleotides+%26+Nucleic+Acids&rft.issn=15257770&rft_id=info:doi/10.1080%2F15257770903170252 L2 - http://www.informaworld.com/smpp/content~db=all~content=a914499768~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Antiviral agents; nucleosides; Nucleotides DO - http://dx.doi.org/10.1080/15257770903170252 ER - TY - JOUR T1 - In vivo 13C magnetic resonance spectroscopy of human brain on a clinical 3 T scanner using [2-13C]glucose infusion and low-power stochastic decoupling AN - 883038866; 15255303 AB - This study presents the detection of [2-13C]glucose metabolism in the carboxylic/amide region in the human brain, and demonstrates that the cerebral metabolism of [2-13C]glucose can be studied in human subjects in the presence of severe hardware constraints of widely available 3 T clinical scanners and with low-power stochastic decoupling. In the carboxylic/amide region of human brain, the primary products of 13C label incorporation from [2-13C]glucose into glutamate, glutamine, aspartate, -aminobutyric acid, and N-acetylaspartate were detected. Unlike the commonly used alkanyl region where lipid signals spread over a broad frequency range, the carboxylic carbon signal of lipids was found to be confined to a narrow range centered at 172.5 ppm and present no spectral interference in the absence of lipid suppression. Comparison using phantoms shows that stochastic decoupling is far superior to the commonly used WALTZ sequence at very low decoupling power at 3 T. It was found that glutamine C1 and C5 can be decoupled using stochastic decoupling at 2.2 W, although glutamine protons span a frequency range of Delta #~700 Hz. Detailed specific absorption rate analysis was also performed using finite difference time domain numerical simulation. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Li, Shizhe AU - Zhang, Yan AU - Wang, Shumin AU - Yang, Jehoon AU - Araneta, Maria Ferraris AU - Farris, Amanda AU - Johnson, Christopher AU - Fox, Stephen AU - Innis, Robert AU - Shen, Jun AD - Magnetic Resonance Spectroscopy Core Facility, NIMH, National Institutes of Health, Bethesda, Maryland, shenj@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 565 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 3 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - N- double prime Acetylaspartate KW - Glutamine KW - Mathematical models KW - Protons KW - Lipids KW - Brain KW - N-Acetylaspartate KW - Stochasticity KW - Carbon KW - Magnetic resonance spectroscopy KW - N.M.R. KW - Glutamic acid KW - amides KW - Metabolism KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883038866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=In+vivo+13C+magnetic+resonance+spectroscopy+of+human+brain+on+a+clinical+3+T+scanner+using+%5B2-13C%5Dglucose+infusion+and+low-power+stochastic+decoupling&rft.au=Li%2C+Shizhe%3BZhang%2C+Yan%3BWang%2C+Shumin%3BYang%2C+Jehoon%3BAraneta%2C+Maria+Ferraris%3BFarris%2C+Amanda%3BJohnson%2C+Christopher%3BFox%2C+Stephen%3BInnis%2C+Robert%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2009-09-01&rft.volume=62&rft.issue=3&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22044 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22044/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Glutamine; N- double prime Acetylaspartate; Mathematical models; Protons; Lipids; Brain; N-Acetylaspartate; Stochasticity; Carbon; Magnetic resonance spectroscopy; N.M.R.; Glutamic acid; amides; Metabolism DO - http://dx.doi.org/10.1002/mrm.22044 ER - TY - JOUR T1 - Exposure to atrazine and selected non-persistent pesticides among corn farmers during a growing season AN - 876235749; 14934651 AB - The aim was to develop quantitative estimates of farmers' pesticide exposure to atrazine and to provide an overview of background levels of selected non-persistent pesticides among corn farmers in a longitudinal molecular epidemiologic study. The study population consisted of 30 Agricultural Health Study farmers from Iowa and 10 non-farming controls. Farmers completed daily and weekly diaries from March to November in 2002 and 2003 on pesticide use and other exposure determinants. Urine samples were collected at 10 time points relative to atrazine application and other farming activities. Pesticide exposure was assessed using urinary metabolites and diaries. The analytical limit of detection (LOD) ranged between 0.1 and 0.2 mu g/l for all pesticide analytes except for isazaphos (1.5 mu g/l) and diazinon (0.7 mu g/l). Farmers had higher geometric mean urinary atrazine mercapturate (AZM) values than controls during planting (1.1 vs 9-fold higher in those with a family history of UGI cancer [median expression (interquartile range), -1,964 (-18,000, -610) versus -18,000 (-18,000, -1036); P = 0.02, Wilcoxon rank-sum test]. Heating status, dysplasia category, age, gender, and smoking were not associated with AhR expression (linear regression; all P values >or= 0.1). AhR expression was higher in patients with a family history of UGI cancer. Such individuals may be more susceptible to the deleterious effects of PAH exposure, including PAH-induced cancer. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Roth, Mark J AU - Wei, Wen-Qiang AU - Baer, Jessica AU - Abnet, Christian C AU - Wang, Guo-Qing AU - Sternberg, Lawrence R AU - Warner, Andrew C AU - Johnson, Laura Lee AU - Lu, Ning AU - Giffen, Carol A AU - Dawsey, Sanford M AU - Qiao, You-Lin AU - Cherry, James AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7232, USA. mr166i@nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 2391 EP - 2396 VL - 18 IS - 9 KW - Biomarkers, Tumor KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Receptors, Aryl Hydrocarbon KW - Index Medicus KW - Cross-Sectional Studies KW - Biomarkers, Tumor -- genetics KW - Air Pollution, Indoor -- adverse effects KW - Risk Factors KW - Humans KW - Gene Expression KW - Aged KW - Middle Aged KW - Male KW - Female KW - Biomarkers, Tumor -- biosynthesis KW - Esophageal Neoplasms -- chemically induced KW - Receptors, Aryl Hydrocarbon -- biosynthesis KW - Esophageal Neoplasms -- metabolism KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Carcinoma, Squamous Cell -- metabolism KW - Carcinoma, Squamous Cell -- chemically induced KW - Receptors, Aryl Hydrocarbon -- genetics KW - Polycyclic Aromatic Hydrocarbons -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734044631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Aryl+hydrocarbon+receptor+expression+is+associated+with+a+family+history+of+upper+gastrointestinal+tract+cancer+in+a+high-risk+population+exposed+to+aromatic+hydrocarbons.&rft.au=Roth%2C+Mark+J%3BWei%2C+Wen-Qiang%3BBaer%2C+Jessica%3BAbnet%2C+Christian+C%3BWang%2C+Guo-Qing%3BSternberg%2C+Lawrence+R%3BWarner%2C+Andrew+C%3BJohnson%2C+Laura+Lee%3BLu%2C+Ning%3BGiffen%2C+Carol+A%3BDawsey%2C+Sanford+M%3BQiao%2C+You-Lin%3BCherry%2C+James&rft.aulast=Roth&rft.aufirst=Mark&rft.date=2009-09-01&rft.volume=18&rft.issue=9&rft.spage=2391&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-1098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Aspects Med. 1999 Feb-Apr;20(1-2):55-70, 137 [10575652] Cancer Prev Res (Phila). 2008 Jul;1(2):100-11 [19138943] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 [10667460] Genes Chromosomes Cancer. 2001 Aug;31(4):390-7 [11433530] Curr Drug Metab. 2001 Jun;2(2):149-64 [11469723] J Biol Chem. 2001 Aug 31;276(35):33101-10 [11423533] Carcinogenesis. 2002 Apr;23(4):611-6 [11960914] Int J Cancer. 2002 Nov 20;102(3):271-4 [12397650] Int J Cancer. 2003 Jan 1;103(1):5-11 [12455047] Chem Res Toxicol. 2003 Mar;16(3):249-60 [12641424] World J Gastroenterol. 2004 Apr 1;10(7):940-4 [15052670] Toxicol Appl Pharmacol. 2004 Sep 15;199(3):210-9 [15364538] Semin Cancer Biol. 2004 Dec;14(6):473-86 [15489140] Cancer Causes Control. 1992 Mar;3(2):107-13 [1562700] Int J Epidemiol. 1992 Oct;21(5):877-82 [1468848] Cancer. 1994 Apr 15;73(8):2027-37 [8156507] Annu Rev Pharmacol Toxicol. 1995;35:307-40 [7598497] Cancer. 1997 Sep 1;80(5):852-7 [9307183] Eur J Cancer. 1998 Apr;34(5):757-8 [9713287] Hum Pathol. 1998 Nov;29(11):1294-8 [9824110] Genes Dev. 1999 Jan 1;13(1):20-5 [9887096] Carcinogenesis. 1999 Feb;20(2):243-8 [10069460] Biochem Pharmacol. 1999 Jul 1;58(1):157-65 [10403529] Carcinogenesis. 2004 Nov;25(11):2275-81 [15297370] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] Gut. 2005 Feb;54(2):187-92 [15647178] Anticancer Res. 2005 Jan-Feb;25(1B):425-8 [15816606] Gut. 2005 Jun;54(6):759-63 [15888779] Genes Chromosomes Cancer. 2005 Nov;44(3):271-8 [16015646] Clin Med. 2005 Sep-Oct;5(5):491-8 [16268333] Lancet Oncol. 2005 Dec;6(12):931-2 [16353404] J Biochem Mol Toxicol. 2005;19(6):368-78 [16421897] Mol Aspects Med. 2006 Apr-Jun;27(2-3):126-39 [16469371] Toxicol In Vitro. 2006 Jun;20(4):426-38 [16198082] Toxicol Lett. 2006 Aug 20;165(2):182-94 [16713138] BMC Cancer. 2006;6:139 [16729889] Nat Rev Cancer. 2006 Dec;6(12):947-60 [17128211] Clin Cancer Res. 2007 Jan 1;13(1):38-45 [17200336] Arch Biochem Biophys. 2007 Aug 15;464(2):207-12 [17481570] Cancer Causes Control. 2008 Feb;19(1):1-12 [17906935] Fam Cancer. 2008;7(1):27-39 [17999161] Acta Cytol. 2008 Jan-Feb;52(1):14-23 [18323271] Biochem Pharmacol. 2000 Jan 1;59(1):65-85 [10605936] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-1098 ER - TY - JOUR T1 - Cigarette smoking and prostate cancer in a prospective US cohort study. AN - 734044151; 19706848 AB - Smoking is an important risk factor for many cancers, yet the relationship between smoking and prostate cancer remains uncertain. We investigated whether smoking affected the risk of prostate cancers within a large prospective cohort study of dietary and environmental cancer risk factors among men ages 50 to 71 upon enrollment in 1995-1996 (n = 283,312). Cox proportional hazards regression models with hazard ratios (HR) and 95% confidence intervals (95% CI) were adjusted for age, race, education, height, body mass index, physical activity, family history of prostate cancer, diabetes, self-reported health status, prostate-specific antigen testing, digital rectal exam, total energy, alpha-tocopherol, calcium, alpha-linolenic acid, selenium, red meat, fish, and tomato intake. There were 14,810 nonadvanced and 1,830 advanced incident prostate cancers identified through 2003, and 394 men died of their disease through 2005. Current smokers had a decreased risk of nonadvanced prostate cancer (HR, 0.82; 95% CI, 0.77-0.88), but an increased risk of fatal prostate cancer (HR, 1.69; 95% CI, 1.25-2.27). Former smoking was also associated with decreased risk of nonadvanced prostate cancers (HR, 0.89; 95% CI, 0.86-0.92), but not fatal prostate cancers (HR, 1.03; 95% CI, 0.83-1.27). There was no apparent association between smoking and advanced prostate cancer. A number of biologically plausible mechanisms could explain these results, including the direct effects of carcinogens in tobacco smoke and the resulting changes in sex hormone or growth factor profiles. These findings suggest that current and former smokers may be at decreased risk of being diagnosed with prostate cancer and current smokers are at an increased risk of dying from prostate cancer. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Watters, Joanne L AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA. wattersj@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 2427 EP - 2435 VL - 18 IS - 9 KW - Index Medicus KW - Environment KW - Prospective Studies KW - Risk Factors KW - Humans KW - Cohort Studies KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - United States -- epidemiology KW - Male KW - Proportional Hazards Models KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- epidemiology KW - Smoking -- adverse effects KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734044151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Cigarette+smoking+and+prostate+cancer+in+a+prospective+US+cohort+study.&rft.au=Watters%2C+Joanne+L%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BAlbanes%2C+Demetrius&rft.aulast=Watters&rft.aufirst=Joanne&rft.date=2009-09-01&rft.volume=18&rft.issue=9&rft.spage=2427&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-09-0252 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 2001 Jun;12(6):761-5 [11484949] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Epidemiol Rev. 2001;23(1):115-25 [11588835] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):604-9 [12869398] J Urol. 2004 Apr;171(4):1543-6 [15017216] Lancet. 2004 Apr 24;363(9418):1346-53 [15110491] Br J Cancer. 2004 Oct 18;91(8):1525-31 [15354219] Am J Epidemiol. 1988 Oct;128(4):796-805 [3421245] Am J Epidemiol. 1991 Mar 1;133(5):437-41 [2000853] J Clin Endocrinol Metab. 1994 Nov;79(5):1310-6 [7962322] J Urol. 1995 Jul;154(1):153-7 [7776411] J Natl Cancer Inst. 1996 Aug 21;88(16):1118-26 [8757191] Am J Epidemiol. 1997 Mar 1;145(5):466-75 [9048521] Am J Epidemiol. 1999 Jan 15;149(2):106-15 [9921955] Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 1):277-82 [10207628] N Engl J Med. 1999 Aug 5;341(6):427-34 [10432328] Cancer. 2006 Jan 15;106(2):320-8 [16342294] Langenbecks Arch Surg. 2006 Nov;391(6):603-13 [17031696] Cancer. 2007 Feb 15;109(4):675-84 [17211863] Urology. 2007 Apr;69(4):721-5 [17445658] Epidemiol Rev. 2007;29:88-97 [17478439] Int J Cancer. 2007 Oct 1;121(7):1571-8 [17450530] Cancer. 2007 Oct 1;110(7):1593-601 [17724671] Cancer Causes Control. 2008 Feb;19(1):25-31 [17906959] J Natl Cancer Inst. 2008 Feb 6;100(3):170-83 [18230794] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Ann Oncol. 2008 May;19(5):996-1002 [18212091] Lancet Oncol. 2008 Jul;9(7):649-56 [18556244] J Urol. 2008 Aug;180(2):658-62; discussion 662 [18554651] Ann Intern Med. 2008 Oct 7;149(7):461-71, W83-8 [18838726] Cancer. 2008 Oct 15;113(8):2053-7 [18780337] Cancer Causes Control. 2009 Aug;20(6):877-86 [19277882] J Clin Epidemiol. 2001 Sep;54(9):935-44 [11520654] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-0252 ER - TY - JOUR T1 - Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. AN - 734038730; 19734418 AB - In chronic lymphocytic leukemia lenalidomide causes striking immune activation, possibly leading to clearance of tumor cells. We conducted this study to investigate the mechanism of action of lenalidomide and the basis for its unique toxicities in chronic lymphocytic leukemia. Patients with relapsed chronic lymphocytic leukemia were treated with lenalidomide 20 mg (n=10) or 10 mg (n=8) daily for 3 weeks on a 6-week cycle. Correlative studies assessed expression of co-stimulatory molecules on tumor cells, T-cell activation, cytokine levels, and changes in lymphocyte subsets. Lenalidomide upregulated the co-stimulatory molecule CD80 on chronic lymphocytic leukemia and mantle cell lymphoma cells but not on normal peripheral blood B cells in vitro. T-cell activation was apparent in chronic lymphocytic leukemia, weak in mantle cell lymphoma, but absent in normal peripheral blood mononuclear cells and correlated with the upregulation of CD80 on B cells. Strong CD80 upregulation and T-cell activation predicted more severe side effects, manifesting in 83% of patients as a cytokine release syndrome within 8-72 h after the first dose of lenalidomide. Serum levels of various cytokines, including tumor necrosis factor-alpha, increased during treatment. CD80 upregulation on tumor cells correlated with rapid clearance of leukemic cells from the peripheral blood. In contrast, neither the severity of the cytokine release syndrome nor the degree of T-cell activation in vitro correlated with clinical response. Upregulation of CD80 on tumor cells and T-cell activation correlate with unique toxicities of lenalidomide in chronic lymphocytic leukemia. However, T-cell activation appears to be dispensable for the drug's anti-tumor effects. This provides a rationale for combinations of lenalidomide with fludarabine or alemtuzumab. JF - Haematologica AU - Aue, Georg AU - Njuguna, Ndegwa AU - Tian, Xin AU - Soto, Susan AU - Hughes, Thomas AU - Vire, Berengere AU - Keyvanfar, Keyvan AU - Gibellini, Federica AU - Valdez, Janet AU - Boss, Carol AU - Samsel, Leigh AU - McCoy, J Philip AU - Wilson, Wyndham H AU - Pittaluga, Stefania AU - Wiestner, Adrian AD - Hematology Branch, National Heart, Lung, and Blood Institute/NIH, 10 Center Drive, Bethesda, MD 20892-1202, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1266 EP - 1273 VL - 94 IS - 9 KW - Antigens, CD80 KW - 0 KW - Antineoplastic Agents KW - Cytokines KW - Thalidomide KW - 4Z8R6ORS6L KW - lenalidomide KW - F0P408N6V4 KW - Index Medicus KW - Syndrome KW - Humans KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Lymphocyte Activation -- drug effects KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Antigens, CD80 -- biosynthesis KW - Antineoplastic Agents -- administration & dosage KW - Up-Regulation -- drug effects KW - Thalidomide -- administration & dosage KW - Cytokines -- metabolism KW - Thalidomide -- analogs & derivatives KW - Leukemia, Lymphocytic, Chronic, B-Cell -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734038730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Haematologica&rft.atitle=Lenalidomide-induced+upregulation+of+CD80+on+tumor+cells+correlates+with+T-cell+activation%2C+the+rapid+onset+of+a+cytokine+release+syndrome+and+leukemic+cell+clearance+in+chronic+lymphocytic+leukemia.&rft.au=Aue%2C+Georg%3BNjuguna%2C+Ndegwa%3BTian%2C+Xin%3BSoto%2C+Susan%3BHughes%2C+Thomas%3BVire%2C+Berengere%3BKeyvanfar%2C+Keyvan%3BGibellini%2C+Federica%3BValdez%2C+Janet%3BBoss%2C+Carol%3BSamsel%2C+Leigh%3BMcCoy%2C+J+Philip%3BWilson%2C+Wyndham+H%3BPittaluga%2C+Stefania%3BWiestner%2C+Adrian&rft.aulast=Aue&rft.aufirst=Georg&rft.date=2009-09-01&rft.volume=94&rft.issue=9&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Haematologica&rft.issn=1592-8721&rft_id=info:doi/10.3324%2Fhaematol.2009.005835 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-08 N1 - Date created - 2009-09-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2001 Jul 1;98(1):210-6 [11418482] J Leukoc Biol. 2001 Jan;69(1):81-8 [11200072] Blood. 2004 Mar 1;103(5):1787-90 [14512311] Immunol Lett. 1996 Apr;50(1-2):95-8 [8793565] J Clin Oncol. 1999 Mar;17(3):791-5 [10071268] J Immunol. 1999 Jul 1;163(1):380-6 [10384139] Clin Cancer Res. 2005 Feb 15;11(4):1490-9 [15746051] J Clin Oncol. 2005 Oct 20;23(30):7697-702 [16186597] Lancet Oncol. 2006 Jun;7(6):480-8 [16750498] Blood. 2006 Nov 15;108(10):3458-64 [16840727] J Clin Oncol. 2006 Dec 1;24(34):5343-9 [17088571] Clin Cancer Res. 2007 Oct 15;13(20):6168-74 [17947483] J Clin Oncol. 2007 Nov 1;25(31):5047 [17971612] J Clin Oncol. 2008 Mar 20;26(9):1544-52 [18285605] J Clin Oncol. 2008 May 20;26(15):2519-25 [18427150] Blood. 2008 Jun 1;111(11):5291-7 [18334676] J Clin Invest. 2008 Jul;118(7):2427-37 [18551193] J Clin Oncol. 2008 Oct 20;26(30):4952-7 [18606983] J Biol Chem. 2002 Mar 8;277(10):7766-75 [11726649] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3324/haematol.2009.005835 ER - TY - JOUR T1 - Interrelationships of adolescent physical activity, screen-based sedentary behaviour, and social and psychological health. AN - 733972014; 19639256 AB - To examine how adolescent physical activity (PA) and screen-based media sedentary behaviours (SBM) relate to psychological and social health and identify cross-national differences in these relationships. Associations were examined in five regions using two Health Behaviour in School-Aged Children (HBSC) countries from each. Self-reported psychological and social health indices such as self-image, perceived health status, and Life Satisfaction were positively related to PA in all five regions but, with a few exceptions, negatively related to SBM. Negative health indices such as health complaints and tobacco use were negatively related to PA but, with exceptions, positively related to SBM. Significant regional differences were present. Regional differences in correlates of PA and SBM suggest cultural differences in potential effects of PA and SBM and the need to tailor school and public health efforts to the different meanings of PA and SBM for positive and negative health consequences. JF - International journal of public health AU - Iannotti, Ronald J AU - Janssen, Ian AU - Haug, Ellen AU - Kololo, Hanna AU - Annaheim, Beatrice AU - Borraccino, Alberto AU - HBSC Physical Activity Focus Group AD - Division of Epidemiology, Statistics, & Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Prevention Research Branch, Bethesda, Maryland 20892-7510, USA. iannottr@mail.nih.gov ; HBSC Physical Activity Focus Group Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 191 EP - 198 VL - 54 Suppl 2 KW - Index Medicus KW - Humans KW - Health Surveys KW - Europe KW - Adolescent KW - Male KW - Female KW - Substance-Related Disorders KW - Mental Health KW - Physical Fitness -- physiology KW - Exercise KW - Sedentary Lifestyle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733972014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+public+health&rft.atitle=Interrelationships+of+adolescent+physical+activity%2C+screen-based+sedentary+behaviour%2C+and+social+and+psychological+health.&rft.au=Iannotti%2C+Ronald+J%3BJanssen%2C+Ian%3BHaug%2C+Ellen%3BKololo%2C+Hanna%3BAnnaheim%2C+Beatrice%3BBorraccino%2C+Alberto%3BHBSC+Physical+Activity+Focus+Group&rft.aulast=Iannotti&rft.aufirst=Ronald&rft.date=2009-09-01&rft.volume=54+Suppl+2&rft.issue=&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=International+journal+of+public+health&rft.issn=1661-8564&rft_id=info:doi/10.1007%2Fs00038-009-5410-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sports Med. 2000 Mar;29(3):167-80 [10739267] Int J Public Health. 2009 Sep;54 Suppl 2:140-50 [19639259] Arch Pediatr Adolesc Med. 2001 May;155(5):554-9 [11343497] Arch Pediatr Adolesc Med. 2001 Aug;155(8):897-902 [11483116] Addiction. 2002 Jun;97(6):707-16 [12084140] Br J Sports Med. 2002 Oct;36(5):360-4 [12351335] Int J Circumpolar Health. 2002 Nov;61(4):319-31 [12546190] Alcohol Alcohol. 2003 May-Jun;38(3):243-8 [12711659] J Stud Alcohol. 2003 Sep;64(5):650-61 [14572187] Med Sci Sports Exerc. 2004 Jan;36(1):86-92 [14707773] Br J Soc Psychol. 1988 Dec;27 ( Pt 4):371-84 [3214701] Am J Epidemiol. 1995 Mar 15;141(6):575-80 [7900725] Am J Public Health. 1996 Nov;86(11):1577-81 [8916523] J Health Soc Behav. 1997 Mar;38(1):21-37 [9097506] Soc Sci Med. 1998 Sep;47(5):665-75 [9690849] J Sch Health. 2004 Nov;74(9):370-7 [15656264] Tob Control. 2005 Apr;14(2):114-7 [15791021] J Adolesc Health. 2005 Jun;36(6):486-93 [15901513] J Pediatr. 2005 Jun;146(6):732-7 [15973308] Pediatrics. 2006 Apr;117(4):1281-90 [16585325] Eur J Public Health. 2006 Oct;16(5):536-41 [16524936] Sports Med. 2006;36(12):1019-30 [17123326] Pediatrics. 2006 Dec;118(6):e1627-34 [17142492] Obes Rev. 2007 Jan;8(1):69-81 [17212797] Nutr Hosp. 2007 Jan-Feb;22(1):89-94 [17260536] Med Sci Sports Exerc. 2007 Jul;39(7):1067-74 [17596773] Nutr Metab Cardiovasc Dis. 2008 Mar;18(3):242-51 [18083016] Int J Pediatr Obes. 2008;3(2):93-101 [18465435] JAMA. 2008 Jul 16;300(3):295-305 [18632544] J Adolesc Health. 2009 May;44(5):493-9 [19380098] Pediatrics. 2001 Feb;107(2):423-6 [11158483] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00038-009-5410-z ER - TY - JOUR T1 - Gender specific trends in alcohol use: cross-cultural comparisons from 1998 to 2006 in 24 countries and regions. AN - 733971659; 19618110 AB - To examine trends in the prevalence of monthly alcohol use and lifetime drunkenness among 15 year olds in 20 European countries, the Russian Federation, Israel, the United States of America, and Canada. Alcohol use prevalence and drunkenness were assessed in the Health Behavior in School-aged Children Survey conducted in each country in 1998, 2002, and 2006. Trends were determined using the Cochran-Mantel-Haenszel test for trends. Average monthly alcohol use across all countries declined from 45.3% to 43.6% and drunkenness declined from 37.2% to 34.8. There was substantial variability across countries, with decreases in some countries and increases or no change in use or drunkenness in others. The overall decline was greater among boys, from 41.2% to 36.7% than among girls, 33.3% to 31.9%. In most of the countries where drinking or drunkenness increased, it was due mainly to increases among girls. Trends in alcohol use and drunkenness varied by country. Drinking and drunkenness remained higher among boys than girls, but the gap between boys and girls declined and girls appear to be catching up with boys in some countries. JF - International journal of public health AU - Simons-Morton, Bruce G AU - Farhat, Tilda AU - ter Bogt, Tom F M AU - Hublet, Anne AU - Kuntsche, Emmanuel AU - Nic Gabhainn, Saoirse AU - Godeau, Emmanuelle AU - Kokkevi, Anna AU - HBSC Risk Behaviour Focus Group AD - Prevention Research Branch, Division of Epidemiology, Statistics, & Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA. mortonb@exchange.nih.gov ; HBSC Risk Behaviour Focus Group Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 199 EP - 208 VL - 54 Suppl 2 KW - Index Medicus KW - Canada -- epidemiology KW - Israel -- epidemiology KW - Alcoholic Intoxication -- epidemiology KW - Humans KW - Health Surveys KW - Cross-Cultural Comparison KW - Europe -- epidemiology KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Russia -- epidemiology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733971659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+public+health&rft.atitle=Gender+specific+trends+in+alcohol+use%3A+cross-cultural+comparisons+from+1998+to+2006+in+24+countries+and+regions.&rft.au=Simons-Morton%2C+Bruce+G%3BFarhat%2C+Tilda%3Bter+Bogt%2C+Tom+F+M%3BHublet%2C+Anne%3BKuntsche%2C+Emmanuel%3BNic+Gabhainn%2C+Saoirse%3BGodeau%2C+Emmanuelle%3BKokkevi%2C+Anna%3BHBSC+Risk+Behaviour+Focus+Group&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2009-09-01&rft.volume=54+Suppl+2&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=International+journal+of+public+health&rft.issn=1661-8564&rft_id=info:doi/10.1007%2Fs00038-009-5411-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Stud Alcohol. 2000 Nov;61(6):799-808 [11188485] J Stud Alcohol Suppl. 2002 Mar;(14):206-25 [12022726] MMWR Surveill Summ. 2004 May 21;53(2):1-96 [15152182] Psychol Addict Behav. 2004 Jun;18(2):160-9 [15238058] MMWR Surveill Summ. 2006 Jun 9;55(5):1-108 [16760893] Alcohol Alcohol Suppl. 2006 Oct-Nov;41(1):i47-55 [17030503] Int J Public Health. 2009 Sep;54 Suppl 2:131-9 [19639260] PLoS Med. 2007 Apr;4(4):e151 [17455992] J Stud Alcohol Drugs. 2007 Jul;68(4):587-96 [17568965] Alcohol Alcohol. 2007 Sep-Oct;42(5):465-73 [17287207] Drug Alcohol Depend. 2008 Jan 11;93(1-2):21-9 [17980512] Pediatrics. 2008 Apr;121 Suppl 4:S290-310 [18381495] Int J Public Health. 2009 Sep;54 Suppl 2:140-50 [19639259] BMC Public Health. 2006;6:280 [17096837] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00038-009-5411-y ER - TY - JOUR T1 - Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation. AN - 733967776; 19542206 AB - Lead (Pb) produces aggresome-like inclusion bodies (IBs) in target cells as a toxic response. Our prior work shows metallothionein (MT) is required for this process. We used MT-I/II double knockout (MT-null) and parental wild-type (WT) cell lines to further explore the formation process of Pb-induced IBs. Unlike WT cells, MT-null cells did not form IBs after Pb exposure. Western blot of cytosol showed soluble MT protein in WT cells was lost during Pb exposure as IBs formed. Transfection of MT-I into MT-null cells allowed IBs formation after Pb exposure. Considering Pb-induced IBs may be like disease-related aggresomes, which often contain alpha-synuclein (Scna), we investigated Scna expression in cells capable (WT) and incapable (MT-null) of producing IBs after Pb exposure. Scna protein showed poor basal expression in MT-null cells. Pb exposure increased Scna expression only in WT cells. MT transfection increased Scna transcript to WT levels. In WT or MT-transfected MT-null cells, Pb-induced Scna expression rapidly increased and then decreased over 48 h as Pb-induced IBs were formed. A direct interaction between Scna and MT was confirmed ex vivo by antibody pulldown assay where the proteins coprecipitated with an antibody to MT. Pb exposure caused increased colocalization of MT and Scna proteins with time only in WT cells. In WT mice after chronic Pb exposure Scna was localized in renal cells containing forming IBs, whereas MT-null mice did not form IBs. Thus, Scna could be component of Pb-induced IBs and, with MT, may play a role in IBs formation. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zuo, Peijun AU - Qu, Wei AU - Cooper, Ryan N AU - Goyer, Robert A AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 100 EP - 108 VL - 111 IS - 1 KW - alpha-Synuclein KW - 0 KW - Lead KW - 2P299V784P KW - DNA KW - 9007-49-2 KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Animals KW - Blotting, Western KW - Transfection KW - Cells, Cultured KW - DNA -- genetics KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Immunohistochemistry KW - DNA -- biosynthesis KW - Mice, Knockout KW - Inclusion Bodies -- pathology KW - Lead -- toxicity KW - Inclusion Bodies -- metabolism KW - Metallothionein -- physiology KW - Metallothionein -- genetics KW - alpha-Synuclein -- physiology KW - alpha-Synuclein -- genetics KW - Inclusion Bodies -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733967776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Potential+role+of+alpha-synuclein+and+metallothionein+in+lead-induced+inclusion+body+formation.&rft.au=Zuo%2C+Peijun%3BQu%2C+Wei%3BCooper%2C+Ryan+N%3BGoyer%2C+Robert+A%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Zuo&rft.aufirst=Peijun&rft.date=2009-09-01&rft.volume=111&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp132 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-03 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2008 Jan 2;28(1):3-9 [18171917] Toxicol Appl Pharmacol. 2007 Nov 15;225(1):1-27 [17904601] Science. 2002 Jun 14;296(5575):1991-5 [12065827] J Biol Chem. 2004 Mar 12;279(11):10128-35 [14699135] Lancet Neurol. 2004 Aug;3(8):496-503 [15261611] Int Rev Exp Pathol. 1973;12:1-77 [4349348] Toxicol Appl Pharmacol. 1980 Dec;56(3):418-31 [7222026] Toxicol Lett. 1984 Jan;20(1):33-9 [6695394] Environ Health Perspect. 1984 Mar;54:117-27 [6203731] Biochem J. 1986 Jan 15;233(2):541-6 [3954751] J Biol Chem. 1989 Oct 15;264(29):16969-72 [2571613] Neurology. 1990 Oct;40(10 Suppl 3):suppl 17-30; discussion 30-1 [2215971] Toxicology. 1992;73(2):127-46 [1319092] Neurotoxicology. 1993 Summer-Fall;14(2-3):45-60 [8247411] Neurology. 1993 Jun;43(6):1173-80 [8170564] J Biol Chem. 1995 Mar 10;270(10):5506-10 [7890668] Environ Health Perspect. 1997 Sep;105(9):928-38 [9300927] Neurology. 1998 Jun;50(6):1885-6 [9633752] Environ Health Perspect. 1998 Dec;106 Suppl 6:1585-7 [9860918] Life Sci. 1999;64(11):PL145-50 [10201648] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 2004 Nov 1;64(21):7766-72 [15520181] Annu Rev Biochem. 2005;74:29-52 [15952880] Brain Res Brain Res Rev. 2005 Nov;49(3):529-54 [16269318] Environ Health Perspect. 2006 Dec;114(12):1872-6 [17185278] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Am J Pathol. 2002 Mar;160(3):1047-56 [11891201] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp132 ER - TY - JOUR T1 - The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. AN - 733967585; 19501164 AB - It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model. JF - Neurobiology of disease AU - Astradsson, Arnar AU - Jenkins, Bruce G AU - Choi, Ji-Kyung AU - Hallett, Penelope J AU - Levesque, Michele A AU - McDowell, Jack S AU - Brownell, Anna-Liisa AU - Spealman, Roger D AU - Isacson, Ole AD - Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA 02478, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 348 EP - 351 VL - 35 IS - 3 KW - Antiparkinson Agents KW - 0 KW - Levodopa KW - 46627O600J KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Gadolinium DTPA KW - K2I13DR72L KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Macaca fascicularis KW - Brain -- pathology KW - Brain -- blood supply KW - Time Factors KW - Male KW - Antiparkinson Agents -- adverse effects KW - Dyskinesia, Drug-Induced -- pathology KW - Levodopa -- therapeutic use KW - Blood-Brain Barrier -- pathology KW - Antiparkinson Agents -- therapeutic use KW - Parkinsonian Disorders -- drug therapy KW - Levodopa -- adverse effects KW - Parkinsonian Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733967585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+disease&rft.atitle=The+blood-brain+barrier+is+intact+after+levodopa-induced+dyskinesias+in+parkinsonian+primates--evidence+from+in+vivo+neuroimaging+studies.&rft.au=Astradsson%2C+Arnar%3BJenkins%2C+Bruce+G%3BChoi%2C+Ji-Kyung%3BHallett%2C+Penelope+J%3BLevesque%2C+Michele+A%3BMcDowell%2C+Jack+S%3BBrownell%2C+Anna-Liisa%3BSpealman%2C+Roger+D%3BIsacson%2C+Ole&rft.aulast=Astradsson&rft.aufirst=Arnar&rft.date=2009-09-01&rft.volume=35&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+disease&rft.issn=1095-953X&rft_id=info:doi/10.1016%2Fj.nbd.2009.05.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-03 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Methods. 2000 Mar 1;96(1):71-6 [10704673] Ann Neurol. 2008 Dec;64 Suppl 2:S122-38 [19127583] Ann Neurol. 2000 Apr;47(4 Suppl 1):S167-76; discussion S176-8 [10762145] Acta Neurochir Suppl. 2000;76:125-9 [11449990] Magn Reson Imaging. 2002 Apr;20(3):221-30 [12117604] Invest Radiol. 2002 Oct;37(10):562-70 [12352165] Nat Med. 2003 Jun;9(6):762-7 [12740572] Ann N Y Acad Sci. 2003 Jun;991:1-14 [12846969] Mov Disord. 2004 Sep;19(9):997-1005 [15372588] J Neurosci. 2004 Oct 27;24(43):9553-60 [15509742] Proc Natl Acad Sci U S A. 1987 Nov;84(22):8169-73 [3500474] Neurology. 1990 Feb;40(2):229-35 [2300240] Magn Reson Med. 1991 Dec;22(2):288-92 [1812359] Mov Disord. 1995 Nov;10(6):731-40 [8749992] Nat Med. 1998 Nov;4(11):1308-12 [9809556] Ann Neurol. 2005 Feb;57(2):176-9 [15668963] Eur J Neurosci. 2005 Sep;22(5):1158-68 [16176358] J Neurosci. 2006 Sep 13;26(37):9448-61 [16971529] Neurobiol Dis. 2007 Aug;27(2):220-7 [17588764] Mult Scler. 2007 Aug;13(7):884-94 [17468443] Stroke. 2008 Apr;39(4):1327-32 [18309161] J Neurosci. 2008 Apr 16;28(16):4201-9 [18417699] Ann Neurol. 2000 Apr;47(4 Suppl 1):S22-32; discussion S32-4 [10762129] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.nbd.2009.05.018 ER - TY - JOUR T1 - Maternal serum theobromine and the development of preeclampsia. AN - 733966060; 19535985 AB - Preeclampsia, a disorder with prominent cardiovascular manifestations, is a cause of maternal, fetal, and infant morbidity and mortality. Chocolate contains compounds that may promote cardiovascular health. A recent study found chocolate consumption during pregnancy, and, particularly, increasing cord serum concentration of theobromine (the primary methylxanthine alkaloid in chocolate), to be associated with reduced occurrence of preeclampsia. We studied 2769 women who comprised the control group from a case-control study of caffeine metabolites and spontaneous abortion nested within the Collaborative Perinatal Project. These women were pregnant between 1959 and 1966, with liveborn infants of at least 28 weeks' gestation. Serum was drawn at 26 weeks' gestation, and assayed for theobromine by high-performance liquid chromatography. Odds ratios (ORs) for preeclampsia were estimated using logistic regression, and adjusted for age, education, prepregnant weight, race, parity, smoking, and gestation at blood draw. Preeclampsia occurred in 68 (2.9%) of 2105 eligible women. Adjusted ORs for preeclampsia were near unity across most third-trimester theobromine concentrations. Adjusted ORs for preeclampsia according to theobromine concentration in serum at <20 weeks' gestation increased with increases in concentration, although estimates were imprecise. This study does not support the previous finding that chocolate consumption is associated with a reduced occurrence of preeclampsia. Unmeasured confounding or reverse causation may account for the positive association between early-pregnancy theobromine and preeclampsia. JF - Epidemiology (Cambridge, Mass.) AU - Klebanoff, Mark A AU - Zhang, Jun AU - Zhang, Cuilin AU - Levine, Richard J AD - Epidemiology Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. mk90h@nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 727 EP - 732 VL - 20 IS - 5 KW - Vasodilator Agents KW - 0 KW - Theobromine KW - OBD445WZ5P KW - Index Medicus KW - Young Adult KW - Odds Ratio KW - Humans KW - Adult KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Pregnancy KW - Vasodilator Agents -- adverse effects KW - Theobromine -- blood KW - Pre-Eclampsia -- epidemiology KW - Vasodilator Agents -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733966060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Maternal+serum+theobromine+and+the+development+of+preeclampsia.&rft.au=Klebanoff%2C+Mark+A%3BZhang%2C+Jun%3BZhang%2C+Cuilin%3BLevine%2C+Richard+J&rft.aulast=Klebanoff&rft.aufirst=Mark&rft.date=2009-09-01&rft.volume=20&rft.issue=5&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e3181aba664 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e3181aba664 ER - TY - JOUR T1 - Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. AN - 733965784; 19275775 AB - The serotonin syndrome is a potential side-effect of serotonin-enhancing drugs, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP). As numerous case reports implicate the atypical opioids tramadol and meperidine in the development of the human serotonin syndrome, we examined tramadol and meperidine as possible causative drugs in the rodent model of the serotonin syndrome in SERT wild-type (+/+), heterozygous (+/-) and knockout (-/-) mice. Comparisons were made with SERT mice treated with either vehicle or morphine, an opioid not implicated in the serotonin syndrome in humans. Here we show that tramadol and meperidine, but not morphine, induce serotonin syndrome-like behaviours in mice, and we show that this response is exaggerated in mice lacking one or two copies of SERT. The exaggerated response to tramadol in SERT-/- mice was blocked by pretreatment with the 5-HT1A antagonist WAY 100635. Further, we show that morphine-, meperidine- and tramadol-induced analgesia is markedly decreased in SERT-/- mice. These studies suggest that caution seems warranted in prescribing or not warning patients receiving SSRIs or MAOIs that dangerous side-effects may occur during concurrent use of tramadol and similar agents. These findings suggest that it is conceivable that there might be increased vulnerability in individuals with SERT polymorphisms that may reduce SERT by more than 50%, the level in SERT+/- mice. JF - The international journal of neuropsychopharmacology AU - Fox, Meredith A AU - Jensen, Catherine L AU - Murphy, Dennis L AD - Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1264, USA. mfox@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1055 EP - 1065 VL - 12 IS - 8 KW - Analgesics, Opioid KW - 0 KW - Piperazines KW - Pyridines KW - Serotonin Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Tramadol KW - 39J1LGJ30J KW - N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide KW - 71IH826FEG KW - Meperidine KW - 9E338QE28F KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Serotonin Antagonists -- pharmacology KW - Pain Measurement -- methods KW - Disease Models, Animal KW - Mice KW - Piperazines -- pharmacology KW - Mice, Knockout KW - Mice, Inbred C57BL KW - Pain Measurement -- drug effects KW - Drug Synergism KW - Pyridines -- pharmacology KW - Female KW - Behavior, Animal -- drug effects KW - Behavioral Symptoms -- genetics KW - Serotonin Plasma Membrane Transport Proteins -- deficiency KW - Meperidine -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Tramadol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733965784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+neuropsychopharmacology&rft.atitle=Tramadol+and+another+atypical+opioid+meperidine+have+exaggerated+serotonin+syndrome+behavioural+effects%2C+but+decreased+analgesic+effects%2C+in+genetically+deficient+serotonin+transporter+%28SERT%29+mice.&rft.au=Fox%2C+Meredith+A%3BJensen%2C+Catherine+L%3BMurphy%2C+Dennis+L&rft.aulast=Fox&rft.aufirst=Meredith&rft.date=2009-09-01&rft.volume=12&rft.issue=8&rft.spage=1055&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+neuropsychopharmacology&rft.issn=1469-5111&rft_id=info:doi/10.1017%2FS146114570900011X LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-04 N1 - Date created - 2009-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anaesth Intensive Care. 2004 Aug;32(4):575-7 [15675220] Eur J Pharmacol. 2005 Mar 21;511(1):21-6 [15777775] Eur J Pharmacol. 2005 May 9;514(2-3):165-74 [15910803] Psychopharmacology (Berl). 2005 Jun;180(1):12-20 [15834538] J Am Med Dir Assoc. 2005 Jul-Aug;6(4):265-9 [16005413] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11545-50 [16055563] Pharmacol Biochem Behav. 2005 Aug;81(4):879-86 [16045972] Br J Anaesth. 2005 Oct;95(4):434-41 [16051647] Clin Neuropharmacol. 2005 Sep-Oct;28(5):205-14 [16239759] Eur J Pharmacol. 2006 Jan 4;529(1-3):105-13 [16325800] Eur J Pharmacol. 2006 Feb 27;532(3):258-64 [16488409] Am J Hum Genet. 2006 May;78(5):815-26 [16642437] Biol Psychiatry. 2006 Jun 1;59(11):1046-51 [16460699] Neuropharmacology. 2006 Sep;51(3):651-8 [16793069] Psychopharmacology (Berl). 2006 Sep;188(1):111-8 [16832657] Psychopharmacology (Berl). 2007 Feb;190(2):221-31 [17102981] Am J Psychiatry. 2007 Feb;164(2):346-7 [17267801] Genes Brain Behav. 2007 Jun;6(4):389-400 [16939636] Psychopharmacology (Berl). 2007 Jul;193(1):97-105 [17393145] Psychosomatics. 2007 Jul-Aug;48(4):361-3 [17600178] Pain. 2007 Aug;130(3):235-48 [17250964] Biol Psychiatry. 2007 Aug 15;62(4):327-31 [17210141] Behav Pharmacol. 2007 Nov;18(7):623-31 [17912046] Neuropharmacology. 2007 Oct;53(5):643-56 [17765930] Br J Anaesth. 2007 Dec;99(6):919 [18006535] Ann Pharmacother. 2002 Oct;36(10):1647-8 [12243617] Life Sci. 2002 Nov 29;72(2):143-52 [12417248] Neuropsychopharmacology. 2002 Dec;27(6):914-23 [12464448] J Psychopharmacol. 2002 Dec;16(4):401 [12503845] Life Sci. 2003 Jan 31;72(11):1221-30 [12570923] J Neurochem. 2003 Mar;84(6):1256-65 [12614326] Anesthesiology. 2003 Jun;98(6):1511-2 [12766667] J Neurochem. 2003 Jul;86(1):210-9 [12807440] QJM. 2003 Sep;96(9):635-42 [12925718] Eur J Neurosci. 2003 Oct;18(8):2203-12 [14622181] Cephalalgia. 2007 Dec;27(12):1421-3 [17868285] Clin Infect Dis. 2008 Jan 15;46(2):264-5 [18171260] South Med J. 2008 Feb;101(2):193-5 [18364623] Brain Res. 2008 May 19;1210:76-83 [18417104] Eur J Pain. 2008 Aug;12(6):790-7 [18187350] Aust Fam Physician. 2008 Aug;37(8):627-9 [18704211] Psychopharmacology (Berl). 2008 Nov;200(4):497-507 [18581097] Psychopharmacology (Berl). 2008 Dec;201(2):203-18 [18712364] Br J Clin Pharmacol. 2008 Nov;66(5):682-8 [18754849] Neuropsychopharmacology. 2009 Jun;34(7):1695-709 [19145225] J Pharmacol Exp Ther. 1999 Dec;291(3):999-1007 [10565817] Synapse. 2000 Feb;35(2):79-95 [10611634] J R Soc Med. 1999 Sep;92(9):474-5 [10645303] Pain. 2000 Nov;88(2):119-24 [11050366] J Neurosci. 2000 Nov 1;20(21):7888-95 [11050108] Aust N Z J Psychiatry. 2000 Dec;34(6):1032-3 [11127616] Psychopharmacology (Berl). 2001 Jan;153(3):327-33 [11271405] Can J Psychiatry. 2001 Feb;46(1):77-9 [11221494] J Clin Psychiatry. 2001 Mar;62(3):205-6 [11305709] Eur J Pharmacol. 2002 Jun 12;445(3):179-85 [12079682] Genes Brain Behav. 2003 Dec;2(6):365-80 [14653308] Ann Pharmacother. 2004 Mar;38(3):411-3 [14970364] Clin Neuropharmacol. 2004 May-Jun;27(3):150-1 [15190240] J Psychopharmacol. 2004 Sep;18(3):404-11 [15358985] Br J Pharmacol. 1969 Jun;36(2):225-39 [4389201] Life Sci. 1976 Sep 15;19(6):777-85 [823389] Biochem Pharmacol. 1982 Apr 15;31(8):1654-5 [7092957] J Pharmacol Exp Ther. 1984 Jan;228(1):133-9 [6694097] Eur J Pharmacol. 1985 Dec 17;119(3):143-52 [4092729] Pharmacol Biochem Behav. 1986 Jun;24(6):1513-9 [2942947] Eur J Pharmacol. 1988 Sep 23;154(3):299-304 [2976671] Physiol Behav. 1989 Jul;46(1):69-74 [2813556] Ann N Y Acad Sci. 1990;600:168-81; discussion 181-2 [2252308] Am J Psychiatry. 1991 Jun;148(6):705-13 [2035713] J Pharmacol Exp Ther. 1992 Jan;260(1):275-85 [1309873] Br J Pharmacol. 1992 Jan;105(1):147-51 [1596676] Drugs. 1994;47 Suppl 1:3-7 [7517823] Br J Clin Pharmacol. 1996 Jan;41(1):7-12 [8824687] Science. 1996 Nov 29;274(5292):1527-31 [8929413] Psychopharmacology (Berl). 1996 Nov;128(2):198-205 [8956381] Ann Pharmacother. 1997 Feb;31(2):175-7 [9034418] J Clin Psychiatry. 1997 Apr;58(4):174-5 [9164430] Br J Anaesth. 1997 Sep;79(3):352-6 [9389855] Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] Depress Anxiety. 1997;6(4):170-3 [9559288] Int J Geriatr Psychiatry. 1998 May;13(5):343-5 [9658268] Life Sci. 1998;63(12):PL175-80 [9749830] Am J Psychiatry. 1999 Apr;156(4):660-1 [10200754] Neurosci Lett. 1999 Mar 5;262(2):113-6 [10203244] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S146114570900011X ER - TY - JOUR T1 - Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line. AN - 733623069; 19426152 AB - During the neoplastic process tumour cells frequently acquire resistance to the antiproliferative signals of transforming growth factor-beta (TGF-beta). Here we examined a human hepatocellular carcinoma cell line (Hep3B-TS) sensitive to TGF-beta signalling, and a derivative line (Hep3B-TR) rendered resistant to TGF-beta by stepwise exposure to TGF-beta(1). Comprehensive molecular cytogenetic analysis revealed that the acquisition of TGF-beta-resistance by Hep3B-TR cells was due to loss of TGF-beta receptor 2 (TGFbetaRII) gene. As demonstrated by spectral karyotyping and array-based comparative genomic hybridization, and in difference to Hep3B-TS cells, which have three rearranged and two normal copies of chromosome 3 that harbour the TGFbetaRII gene, Hep3B-TR cells have four rearranged and one apparently normal chromosome 3, which nonetheless underwent a critical microdeletion at the site of TGFbetaRII gene. Gene expression analysis using an oligonucleotide microarray of 21,397 genes showed that Hep3B-TR differentially expressed 307 genes, out of which 197 and 110 were up- and down-regulated, respectively, compared to Hep3B-TS. Six of differentially expressed genes were identified as downstream targets of the tumour necrosis factor (TNF) gene, suggesting that loss of TGFbetaRII triggered activation of the TNF pathway known to be regulated by TGF-beta(1) network. On the functional level, the TGF-beta-resistant Hep3B-TR cells displayed significantly enhanced capacity for anchorage independent growth and cell migration in vitro, and also increased tumorigenicity in vivo and in vitro and in vivo tumorigenicity compared with parental sensitive cells. JF - Journal of cellular and molecular medicine AU - Zimonjic, Drazen B AU - Zhou, Xiaoling AU - Lee, Ju-Seog AU - Ullmannova-Benson, Veronika AU - Tripathi, Veenu AU - Thorgeirsson, Snorri S AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4262, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 3985 EP - 3992 VL - 13 IS - 9B KW - Transforming Growth Factor beta1 KW - 0 KW - Index Medicus KW - Karyotyping KW - Cell Movement KW - Neoplasm Invasiveness KW - Comparative Genomic Hybridization KW - Wound Healing KW - Models, Genetic KW - Humans KW - In Situ Hybridization, Fluorescence KW - Gene Rearrangement KW - Cell Line, Tumor KW - Cell Proliferation KW - Gene Deletion KW - Carcinoma, Hepatocellular -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733623069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=Acquired+genetic+and+functional+alterations+associated+with+transforming+growth+factor+beta+type+I+resistance+in+Hep3B+human+hepatocellular+carcinoma+cell+line.&rft.au=Zimonjic%2C+Drazen+B%3BZhou%2C+Xiaoling%3BLee%2C+Ju-Seog%3BUllmannova-Benson%2C+Veronika%3BTripathi%2C+Veenu%3BThorgeirsson%2C+Snorri+S%3BPopescu%2C+Nicholas+C&rft.aulast=Zimonjic&rft.aufirst=Drazen&rft.date=2009-09-01&rft.volume=13&rft.issue=9B&rft.spage=3985&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=1582-4934&rft_id=info:doi/10.1111%2Fj.1582-4934.2009.00769.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-23 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1582-4934.2009.00769.x ER - TY - JOUR T1 - Antipsychotics in children and adolescents: increasing use, evidence for efficacy and safety concerns. AN - 733570485; 19467582 AB - Second-generation antipsychotics (SGA) are increasingly used to treat children and adolescents. The European College of Neuro-psychopharmacology convened an expert panel to review relevant efficacy and safety data, and identify needs for further research. Controlled studies support the short-term efficacy of several SGA for treating psychosis, mania, and aggression within certain diagnostic categories. Except for clozapine, no clinically significant superiority in efficacy has been demonstrated for any specific antipsychotic, including both first- and second-generation agents, in children and adolescents. Major differences exist, however, with respect to type and severity of adverse effects; therefore the choice of treatment is primarily guided by tolerability and safety considerations. Children appear to be at higher risk than adults for a number of adverse effects, such as extrapyramidal symptoms and metabolic and endocrine abnormalities. While the safety profile during acute and intermediate treatment has been evaluated, the distal benefit/risk ratio during long-term treatment remains to be determined. Research is also needed to understand the mechanisms underlying antipsychotic-induced toxicities in order to develop effective preventive and treatment strategies. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Vitiello, Benedetto AU - Correll, Christoph AU - van Zwieten-Boot, Barbara AU - Zuddas, Alessandro AU - Parellada, Mara AU - Arango, Celso AD - National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 629 EP - 635 VL - 19 IS - 9 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Dyskinesia, Drug-Induced KW - Metabolic Diseases -- chemically induced KW - Humans KW - Endocrine System Diseases -- chemically induced KW - Child KW - Adolescent KW - Risk Assessment KW - Aggression -- drug effects KW - Antipsychotic Agents -- therapeutic use KW - Bipolar Disorder -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733570485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Antipsychotics+in+children+and+adolescents%3A+increasing+use%2C+evidence+for+efficacy+and+safety+concerns.&rft.au=Vitiello%2C+Benedetto%3BCorrell%2C+Christoph%3Bvan+Zwieten-Boot%2C+Barbara%3BZuddas%2C+Alessandro%3BParellada%2C+Mara%3BArango%2C+Celso&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2009-09-01&rft.volume=19&rft.issue=9&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=1873-7862&rft_id=info:doi/10.1016%2Fj.euroneuro.2009.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-30 N1 - Date created - 2009-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.euroneuro.2009.04.008 ER - TY - JOUR T1 - Characterizing gait, locomotor status, and disease severity in children and adolescents with Friedreich ataxia. AN - 67681786; 19809393 AB - The purpose of this study was to describe gait parameters in children and adolescents with a diagnosis of Friedreich ataxia (FA) and examine the relationship between disease severity, measured by the Friedreich Ataxia Rating Scale (FARS) and gait parameters. The study examined whether FARS scores can discriminate between those who walk independently and those who require assistance. Thirty-eight children (aged 5-11 years) and adolescents (aged 12-17 years) with genetically confirmed FA were divided into two groups based on locomotor status: group 1, subjects who were able to walk independently, and group 2, subjects who required assistance for walking. Temporal and spatial gait parameters were collected using the Stride Analyzer computerized foot switch system and compared with age-matched normative data. The FARS was used to measure disease severity. Correlation coefficients and the Mann-Whitney U test of differences were used to evaluate associations and discern differences between groups. In subjects with FA, gait parameters of velocity and cadence were slower and stride length was shorter compared with age-matched children without disabilities. These parameters were significantly correlated with FARS score (r = 0.696, 0.667, 0.537; respectively, all P values <0.001). Total FARS scores were correlated with locomotor status (ç value r = 0.623; P < 0.01) and could categorize subjects into groups based on independent walking or need for assistance, 73% and 87% of the time, respectively. Subjects with FA exhibited specific abnormal gait characteristics relative to age-matched individuals. Disease severity, as measured by the FARS, was associated with gait velocity, stride length, and cadence. FARS scores can be used to categorize subjects by locomotor status and may be a useful screening tool to identify those requiring assistance. JF - Journal of neurologic physical therapy : JNPT AU - Croarkin, Earllaine AU - Maring, Joyce AU - Pfalzer, Lucinda AU - Harris-Love, Michael AU - Siegel, Karen AU - DiProspero, Nicholas AD - National Institutes of Health, Bethesda, Maryland, USA. earllaine@verizon.net Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 144 EP - 149 VL - 33 IS - 3 SN - 1557-0576, 1557-0576 KW - Antioxidants KW - 0 KW - Ubiquinone KW - 1339-63-5 KW - idebenone KW - HB6PN45W4J KW - Index Medicus KW - Antioxidants -- adverse effects KW - Humans KW - Walking KW - Predictive Value of Tests KW - Child KW - Gait Apraxia -- physiopathology KW - Gait Apraxia -- drug therapy KW - Adolescent KW - Child, Preschool KW - Antioxidants -- administration & dosage KW - Severity of Illness Index KW - Ubiquinone -- administration & dosage KW - Friedreich Ataxia -- physiopathology KW - Friedreich Ataxia -- drug therapy KW - Motor Activity KW - Ubiquinone -- adverse effects KW - Gait KW - Ubiquinone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67681786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurologic+physical+therapy+%3A+JNPT&rft.atitle=Characterizing+gait%2C+locomotor+status%2C+and+disease+severity+in+children+and+adolescents+with+Friedreich+ataxia.&rft.au=Croarkin%2C+Earllaine%3BMaring%2C+Joyce%3BPfalzer%2C+Lucinda%3BHarris-Love%2C+Michael%3BSiegel%2C+Karen%3BDiProspero%2C+Nicholas&rft.aulast=Croarkin&rft.aufirst=Earllaine&rft.date=2009-09-01&rft.volume=33&rft.issue=3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurologic+physical+therapy+%3A+JNPT&rft.issn=15570576&rft_id=info:doi/10.1097%2FNPT.0b013e3181b5112e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-05 N1 - Date created - 2009-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NPT.0b013e3181b5112e ER - TY - JOUR T1 - Three-year follow-up of syndromal antisocial behavior in adults: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. AN - 67681473; 19538901 AB - To present nationally representative findings on total antisocial personality disorder (ASPD) symptoms, major violations of others' rights (MVOR), and violent symptoms over a 3-year follow-up in Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions among adults diagnosed at Wave 1 with ASPD versus syndromal adult antisocial behavior without conduct disorder before age 15 years (AABS, not a codable DSM-IV disorder). Face-to-face interviews were conducted with 34,653 respondents aged 18 years and older. Antisocial syndromes and comorbid lifetime substance use, mood, and 6 additional personality disorders were diagnosed at Wave 1 using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). The Wave 2 AUDADIS-IV assessed antisocial symptoms over follow-up, lifetime attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder, and borderline, narcissistic, and schizotypal personality disorders. Wave 1 was conducted in 2001-2002 and Wave 2 in 2004-2005 by the National Institute on Alcohol Abuse and Alcoholism. In unadjusted analyses, respondents with ASPD reported significantly more total, MVOR, and violent symptoms over follow-up than did respondents with AABS. Adjustment for baseline sociodemographics and psychiatric comorbidity attenuated these associations; after further adjustment for parallel antisocial symptom counts from age 15 years to Wave 1, associations with antisocial syndromes disappeared. Independent Wave 1 predictors of persistent antisociality over follow-up included male sex, not being married or cohabiting, low income, high school or less education, lifetime drug use disorders, additional personality disorders, and ADHD. The distinction between ASPD and AABS holds limited value in predicting short-term course of antisocial symptomatology among adults. However, the prediction of persistent antisociality by psychiatric comorbidity argues for comprehensive diagnostic assessments, treatment of all identified disorders, and investigation of whether treatment of comorbidity might hasten remission of antisociality. Copyright 2009 Physicians Postgraduate Press, Inc. JF - The Journal of clinical psychiatry AU - Goldstein, Risë B AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Room 3068, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, MS 9304, 5635 Fishers Lane, Bethesda, Maryland 20892-9304, USA. goldster@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1237 EP - 1249 VL - 70 IS - 9 KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Age Factors KW - Violence -- statistics & numerical data KW - Humans KW - Conduct Disorder -- epidemiology KW - Longitudinal Studies KW - Comorbidity KW - Alcoholism -- epidemiology KW - Conduct Disorder -- diagnosis KW - Adult KW - Health Surveys KW - Follow-Up Studies KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - United States -- epidemiology KW - Violence -- psychology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Attention Deficit and Disruptive Behavior Disorders -- diagnosis KW - Antisocial Personality Disorder -- epidemiology KW - Attention Deficit and Disruptive Behavior Disorders -- epidemiology KW - Antisocial Personality Disorder -- diagnosis KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67681473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Three-year+follow-up+of+syndromal+antisocial+behavior+in+adults%3A+results+from+the+Wave+2+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2009-09-01&rft.volume=70&rft.issue=9&rft.spage=1237&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/10.4088%2FJCP.08m04545 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-21 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Can J Psychiatry. 2001 Sep;46(7):597-608 [11582820] J Trauma. 2001 Oct;51(4):758-66 [11586172] J Abnorm Child Psychol. 2002 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[15886870] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Clin Psychiatry. 2005 Nov;66(11):1351-61 [16420070] Am J Psychiatry. 2006 May;163(5):827-32 [16648323] J Clin Psychiatry. 2006 Mar;67(3):363-74 [16649821] J Abnorm Child Psychol. 2006 Oct;34(5):737-55 [17033935] Curr Psychiatry Rep. 2007 Feb;9(1):46-52 [17257514] Int Rev Psychiatry. 2007 Feb;19(1):25-38 [17365156] Arch Gen Psychiatry. 2007 Apr;64(4):476-84 [17404124] Alcohol Clin Exp Res. 2007 May;31(5):814-28 [17391341] Clin Psychol Rev. 2007 Jun;27(5):607-27 [17331630] Psychol Med. 2007 Jul;37(7):1047-59 [17335637] J Clin Psychiatry. 2007 Jul;68(7):998-1009 [17685734] Drug Alcohol Depend. 2007 Oct 8;90(2-3):145-58 [17433571] J Am Acad Child Adolesc Psychiatry. 2007 Oct;46(10):1250-62 [17885566] Curr Psychiatry Rep. 2007 Oct;9(5):420-6 [17915083] Psychol Med. 2007 Dec;37(12):1731-41 [17451627] J Abnorm Psychol. 2007 Nov;116(4):645-66 [18020714] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] Can J Psychiatry. 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Abuse. 2001 Aug;27(3):453-82 [11506262] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4088/JCP.08m04545 ER - TY - JOUR T1 - Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides. AN - 67675937; 19796080 AB - Synthetic oligodeoxynucleotides (ODN) capable of "neutralizing" or "inhibiting" immune responses have been described. This review will focus on the properties of phosphorothioate ODN that mimic the immunosuppressive activity of the repetitive TTAGGG motifs present in mammalian telomeres. These TTAGGG multimers block the production of pro-inflammatory and T helper type 1 cytokines elicited when immune cells are activated by a wide variety of Toll-like receptor ligands, polyclonal activators, and antigens. Several mechanisms contribute to the suppressive activity of such ODN. Ongoing microarray studies indicate that suppressive ODN interfere with the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT4, thereby blocking the inflammation mediated by STAT-associated signaling cascades. In animal models, suppressive ODN can be used to prevent or treat diseases characterized by persistent immune activation, including collagen-induced arthritis, inflammatory arthritis, systemic lupus erythematosus, silicosis, and toxic shock. These findings suggest that TTAGGG multimers may find broad use in the treatment of diseases characterized by over-exuberant/persistent immune activation. JF - Annals of the New York Academy of Sciences AU - Klinman, Dennis M AU - Tross, Debbie AU - Klaschik, Sven AU - Shirota, Hidekazu AU - Sato, Takeshi AD - Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, USA. klinmand@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 80 EP - 88 VL - 1175 KW - Immunologic Factors KW - 0 KW - Immunosuppressive Agents KW - Oligodeoxyribonucleotides KW - Phosphorothioate Oligonucleotides KW - Index Medicus KW - Animals KW - Pneumonia -- immunology KW - Base Sequence KW - Shock, Septic -- immunology KW - Pneumonia -- therapy KW - Humans KW - Silicosis -- immunology KW - Autoimmune Diseases -- therapy KW - Mice KW - Shock, Septic -- therapy KW - Silicosis -- therapy KW - Autoimmune Diseases -- immunology KW - Oligodeoxyribonucleotides -- therapeutic use KW - Immunologic Factors -- therapeutic use KW - Immunologic Factors -- immunology KW - Phosphorothioate Oligonucleotides -- therapeutic use KW - Oligodeoxyribonucleotides -- immunology KW - Immunosuppressive Agents -- immunology KW - Phosphorothioate Oligonucleotides -- immunology KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67675937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Therapeutic+applications+and+mechanisms+underlying+the+activity+of+immunosuppressive+oligonucleotides.&rft.au=Klinman%2C+Dennis+M%3BTross%2C+Debbie%3BKlaschik%2C+Sven%3BShirota%2C+Hidekazu%3BSato%2C+Takeshi&rft.aulast=Klinman&rft.aufirst=Dennis&rft.date=2009-09-01&rft.volume=1175&rft.issue=&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.04970.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1749-6632.2009.04970.x ER - TY - JOUR T1 - De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. AN - 67657100; 19501198 AB - Mutations in POLG are a major contributor to pediatric and adult mitochondrial diseases. However, the consequences of many POLG mutations are not well understood. We investigated the molecular cause of Alpers syndome in a patient harboring the POLG mutations A467T in trans with c.2157+5_+6 gc-->ag in intron 12. Analysis of transcripts arising from the c.2157+5_+6 gc-->ag allele revealed alternative splicing with an insertion of 30 intronic nucleotides leading to a premature termination codon. These transcripts were subsequently removed through nonsense-mediated decay, leading to haplotype insufficiency due to expression of the A467T allele and decreased expression of the c.2157+5_+6 gc-->ag allele, which is likely responsible for the Alpers syndrome phenotype. JF - Mitochondrion AU - Chan, Sherine S L AU - Naviaux, Robert K AU - Basinger, Alice A AU - Casas, Kari A AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 340 EP - 345 VL - 9 IS - 5 KW - Codon, Nonsense KW - 0 KW - POLG protein, human KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Infant KW - Base Sequence KW - Haplotypes KW - RNA Splicing KW - Humans KW - RNA Stability KW - Point Mutation KW - Molecular Sequence Data KW - Mutagenesis, Insertional KW - Male KW - Diffuse Cerebral Sclerosis of Schilder -- genetics KW - Mutation KW - DNA-Directed DNA Polymerase -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67657100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=De+novo+mutation+in+POLG+leads+to+haplotype+insufficiency+and+Alpers+syndrome.&rft.au=Chan%2C+Sherine+S+L%3BNaviaux%2C+Robert+K%3BBasinger%2C+Alice+A%3BCasas%2C+Kari+A%3BCopeland%2C+William+C&rft.aulast=Chan&rft.aufirst=Sherine+S&rft.date=2009-09-01&rft.volume=9&rft.issue=5&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=1872-8278&rft_id=info:doi/10.1016%2Fj.mito.2009.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-09 N1 - Date created - 2009-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2003 Apr 22;60(8):1354-6 [12707443] Hum Mutat. 2008 Sep;29(9):E150-72 [18546365] Hum Mutat. 2003 Dec;22(6):498-9 [14635118] Ann Neurol. 2004 May;55(5):706-12 [15122711] J Mol Biol. 1991 Jul 5;220(1):49-65 [2067018] J Neurol Neurosurg Psychiatry. 1995 Mar;58(3):320-5 [7897414] Nucleic Acids Res. 1996 Sep 1;24(17):3439-52 [8811101] Ann Neurol. 1999 Jan;45(1):54-8 [9894877] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Brain. 2005 Apr;128(Pt 4):723-31 [15689359] Ann Med. 2005;37(3):222-32 [16019721] Ann Neurol. 2005 Sep;58(3):491 [16130100] J Biol Chem. 2005 Sep 9;280(36):31341-6 [16024923] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] Ann Neurol. 2002 Aug;52(2):211-9 [12210792] Neurology. 2005 Nov 8;65(9):1493-5 [16177225] DNA Repair (Amst). 2005 Dec 8;4(12):1381-9 [16181814] Neurology. 2006 May 9;66(9):1439-41 [16682683] J Hepatol. 2006 Jul;45(1):108-16 [16545482] Brain. 2006 Jul;129(Pt 7):1674-84 [16621917] Brain. 2006 Jul;129(Pt 7):1685-92 [16638794] Eur J Hum Genet. 2006 Aug;14(8):917-22 [16639411] Eur J Pediatr. 2007 Mar;166(3):229-34 [16957900] Annu Rev Med. 2008;59:131-46 [17892433] Hum Mol Genet. 2008 Aug 15;17(16):2496-506 [18487244] Biochim Biophys Acta. 2009 May;1787(5):312-9 [19010300] J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):126-9 [19252446] Neurology. 2003 Oct 14;61(7):903-8 [14557557] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mito.2009.05.002 ER - TY - JOUR T1 - Pesticide exposure and hypertensive disorders during pregnancy. AN - 67649889; 19750103 AB - Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions. Our goal was to examine whether pesticide exposure during pregnancy was associated with hypertensive disorders of pregnancy. We analyzed self-reported data from 11,274 wives of farmers enrolled in the Agricultural Health Study (AHS) between 1993 and 1997. Using logistic regression models, we estimated the adjusted odds ratios (AORs) for PIH and PE associated with pesticide-related activities during the first trimester of pregnancy. First-trimester residential and agricultural activities with potential exposure to pesticides were associated with both PIH [residential AOR = 1.27; 95% confidence interval (CI), 1.02-1.60; agricultural AOR = 1.60; 95% CI, 1.05-2.45] and PE (residential AOR = 1.32; 95% CI, 1.02-1.70; agricultural AOR = 2.07; 95% CI, 1.34-3.21). Exposure to pesticides during pregnancy may increase the risk of hypertensive disorders of pregnancy. Laboratory research may provide insights into relationships between pesticide exposure and hypertensive diseases of pregnancy. JF - Environmental health perspectives AU - Saldana, Tina M AU - Basso, Olga AU - Baird, Donna D AU - Hoppin, Jane A AU - Weinberg, Clarice R AU - Blair, Aaron AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Social and Scientific Systems, Inc., 1009 Slater Road, Durham, NC 27703, USA. saldana@niehs.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1393 EP - 1396 VL - 117 IS - 9 KW - Pesticides KW - 0 KW - Index Medicus KW - pregnancy-induced hypertension KW - pesticide exposure KW - preeclampsia KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Pregnancy KW - Hypertension -- complications KW - Hypertension -- chemically induced KW - Pregnancy Complications, Cardiovascular -- chemically induced KW - Environmental Exposure KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67649889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Pesticide+exposure+and+hypertensive+disorders+during+pregnancy.&rft.au=Saldana%2C+Tina+M%3BBasso%2C+Olga%3BBaird%2C+Donna+D%3BHoppin%2C+Jane+A%3BWeinberg%2C+Clarice+R%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Saldana&rft.aufirst=Tina&rft.date=2009-09-01&rft.volume=117&rft.issue=9&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900672 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-16 N1 - Date created - 2009-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Fam Physician. 2004 Dec 15;70(12):2317-24 [15617295] Am J Obstet Gynecol. 2004 Nov;191(5):1655-60 [15547538] N Engl J Med. 2005 Jun 16;352(24):2477-86 [15951574] Diabetes Care. 2006 Feb;29(2):232-5 [16443865] Int J Gynaecol Obstet. 2006 Jul;94(1):12-6 [16733056] Diabetes Care. 2007 Mar;30(3):529-34 [17327316] BMC Public Health. 2007;7:168 [17650297] Am J Obstet Gynecol. 2008 Jan;198(1):7-22 [18166297] Am J Hypertens. 2008 May;21(5):521-6 [18437143] Am J Obstet Gynecol. 2008 May;198(5):e11-3 [18241822] Am J Ind Med. 1988;14(2):177-88 [3207103] Baillieres Best Pract Res Clin Obstet Gynaecol. 1999 Mar;13(1):41-57 [10746092] Toxicology. 2000 Apr 20;146(1):1-13 [10773358] Endocr Rev. 2001 Feb;22(1):36-52 [11159815] Hypertension. 2001 Feb;37(2):232-9 [11230277] Obstet Gynecol. 2001 Apr;97(4):533-8 [11275024] Am Fam Physician. 2001 Jul 15;64(2):263-70, 216 [11476271] Epidemiology. 2002 Jan;13(1):94-9 [11805592] J Clin Endocrinol Metab. 2002 Apr;87(4):1563-8 [11932283] Curationis. 2000 Dec;23(4):76-80 [11949296] Placenta. 2002 May;23(5):359-72 [12061851] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Clin Lab Med. 2003 Jun;23(2):413-42 [12848452] IMS Ind Med Surg. 1972 May;41(5):9-12 [4503277] Arch Environ Health. 1972 Oct;25(4):265-70 [5055677] J Occup Med. 1975 Mar;17(3):182-5 [1123687] Vet Hum Toxicol. 1990 Dec;32(6):521-3 [1702244] Public Health Rep. 1991 Jul-Aug;106(4):393-9 [1908590] J Occup Med. 1993 Sep;35(9):943-9 [8229348] Am J Ind Med. 1994 Mar;25(3):349-59 [8160655] Am J Obstet Gynecol. 1995 Jul;173(1):146-56 [7631672] Epidemiology. 1995 Jul;6(4):391-5 [7548347] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):503-11 [15910416] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900672 ER - TY - JOUR T1 - Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. AN - 67648449; 19735292 AB - Gamma oscillations are a prominent feature of hippocampal network activity, but their functional role remains debated, ranging from mere epiphenomena to being crucial for information processing. Similarly, persistent gamma oscillations sometimes appear prior to epileptic discharges in patients with mesial temporal sclerosis. However, the significance of this activity in hippocampal excitotoxicity is unclear. We assessed the relationship between kainic acid (KA)-induced gamma oscillations and excitotoxicity in genetically engineered mice in which N-methyl-D-aspartic acid receptor deletion was confined to CA3 pyramidal cells. Mutants showed reduced CA3 pyramidal cell firing and augmented sharp wave-ripple activity, resulting in higher susceptibility to KA-induced seizures, and leading to strikingly selective neurodegeneration in the CA1 subfield. Interestingly, the increase in KA-induced gamma-aminobutyric acid (GABA) levels, and the persistent 30-50-Hz gamma oscillations, both of which were observed in control mice prior to the first seizure discharge, were abolished in the mutants. Consequently, on subsequent days, mutants manifested prolonged epileptiform activity and massive neurodegeneration of CA1 cells, including local GABAergic neurons. Remarkably, pretreatment with the potassium channel blocker alpha-dendrotoxin increased GABA levels, restored gamma oscillations, and prevented CA1 degeneration in the mutants. These results demonstrate that the emergence of low-frequency gamma oscillations predicts increased resistance to KA-induced excitotoxicity, raising the possibility that gamma oscillations may have potential prognostic value in the treatment of epilepsy. JF - The European journal of neuroscience AU - Jinde, Seiichiro AU - Belforte, Juan E AU - Yamamoto, Jun AU - Wilson, Matthew A AU - Tonegawa, Susumu AU - Nakazawa, Kazu AD - Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, MD 20892, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1036 EP - 1055 VL - 30 IS - 6 KW - Excitatory Amino Acid Agonists KW - 0 KW - Fluoresceins KW - NR1 NMDA receptor KW - Organic Chemicals KW - Receptors, N-Methyl-D-Aspartate KW - fluoro jade KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Analysis of Variance KW - Signal Processing, Computer-Assisted KW - Cell Count KW - Membrane Potentials -- physiology KW - Mice KW - Electrophysiology KW - Mice, Transgenic KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Excitatory Amino Acid Agonists -- pharmacology KW - Periodicity KW - Membrane Potentials -- drug effects KW - gamma-Aminobutyric Acid -- metabolism KW - Staining and Labeling KW - Receptors, N-Methyl-D-Aspartate -- genetics KW - Immunohistochemistry KW - Oscillometry KW - Cell Death -- physiology KW - Action Potentials -- physiology KW - Kainic Acid -- pharmacology KW - Neurons -- metabolism KW - Hippocampus -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Action Potentials -- drug effects KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67648449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Lack+of+kainic+acid-induced+gamma+oscillations+predicts+subsequent+CA1+excitotoxic+cell+death.&rft.au=Jinde%2C+Seiichiro%3BBelforte%2C+Juan+E%3BYamamoto%2C+Jun%3BWilson%2C+Matthew+A%3BTonegawa%2C+Susumu%3BNakazawa%2C+Kazu&rft.aulast=Jinde&rft.aufirst=Seiichiro&rft.date=2009-09-01&rft.volume=30&rft.issue=6&rft.spage=1036&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=1460-9568&rft_id=info:doi/10.1111%2Fj.1460-9568.2009.06896.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-09-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2006 Oct;24(8):2191-202 [17074044] J Neurophysiol. 2006 Dec;96(6):3028-41 [16971683] Nat Rev Neurosci. 2007 Jan;8(1):45-56 [17180162] Brain Res. 2007 Apr 13;1141:74-83 [17300765] J Clin Neurophysiol. 2007 Apr;24(2):154-64 [17414971] Trends Neurosci. 2007 Jul;30(7):343-9 [17532059] Epilepsy Behav. 2008 Jul;13(1):25-31 [18439878] PLoS One. 2008;3(6):e2473 [18575605] Science. 2008 Jul 4;321(5885):53-7 [18599766] Hippocampus. 2008;18(9):899-908 [18493949] J Neurosci. 2008 Oct 22;28(43):10928-36 [18945900] Nature. 2009 Jun 4;459(7247):663-7 [19396156] J Physiol. 1986 Jul;376:13-29 [2879036] Brain Res. 1986 Nov 29;398(2):242-52 [3026567] Science. 1989 Mar 10;243(4896):1319-25 [2646715] Epilepsia. 2000 Mar;41(3):297-307 [10714401] Brain Res Bull. 2000 May 15;52(2):89-98 [10808078] Brain Res. 2000 Aug 25;874(2):123-30 [10960596] Neurosci Lett. 2000 Nov 3;293(3):183-6 [11036191] Neuron. 2000 Nov;28(2):585-94 [11144366] J Neurosci. 2001 May 15;21(10):RC145 [11319243] Australas Phys Eng Sci Med. 2001 Mar;24(1):37-48 [11458571] J Neurosci. 2001 Sep 15;21(18):7089-98 [11549719] Neuroscience. 2001;107(3):395-404 [11718995] Neurosci Lett. 2002 Feb 8;319(1):17-20 [11814643] Epilepsy Res. 2002 Feb;48(3):199-206 [11904238] J Neurophysiol. 2002 Jul;88(1):523-7 [12091575] Science. 2002 Jul 12;297(5579):211-8 [12040087] Neuroscience. 2003;116(1):201-11 [12535953] Neuron. 2003 Apr 24;38(2):305-15 [12718863] J Neurosci. 2003 Jun 15;23(12):5337-41 [12832559] J Physiol. 2003 Aug 1;550(Pt 3):873-87 [12807984] Neuroscience. 2003;122(2):551-61 [14614919] Brain. 2004 Jul;127(Pt 7):1496-506 [15155522] Science. 2004 Jun 25;304(5679):1926-9 [15218136] J Neurosci. 2004 Oct 27;24(43):9658-68 [15509753] Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94 [4110397] Annu Rev Neurosci. 1978;1:395-415 [386906] Neuroscience. 1980;5(6):991-1014 [7402461] Neuroscience. 1981;6(7):1361-91 [7266871] Life Sci. 1981 Nov 16;29(20):2031-42 [7031398] Science. 1982 May 14;216(4547):745-7 [7079735] J Physiol. 1982 Feb;323:377-91 [6124634] Ann Neurol. 1982 May;11(5):491-8 [7103425] Adv Neurol. 1983;34:129-39 [6829328] Neuroscience. 1985 Feb;14(2):375-403 [2859548] Naunyn Schmiedebergs Arch Pharmacol. 1985 Aug;330(2):77-83 [2413375] Nature. 1986 Jul 17-23;322(6076):263-5 [2874492] Toxicon. 1988;26(11):1009-15 [3245048] Proc Natl Acad Sci U S A. 1989 Jul;86(13):5183-7 [2567996] Exp Brain Res. 1990;79(1):157-66 [2311692] Neurotoxicology. 1990 Winter;11(4):593-600 [2087285] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7650-3 [1652757] Electroencephalogr Clin Neurophysiol. 1992 Feb;82(2):155-9 [1370786] J Clin Neurophysiol. 1992 Jul;9(3):441-8 [1517412] Science. 1993 Aug 20;261(5124):1055-8 [8351520] J Neurosci. 1994 Oct;14(10):6160-70 [7931570] Nature. 1995 Feb 16;373(6515):612-5 [7854418] Electroencephalogr Clin Neurophysiol. 1995 May;94(5):326-37 [7774519] Annu Rev Neurosci. 1995;18:555-86 [7605074] Prog Neurobiol. 1994 Jan;42(1):1-32 [7480784] J Neurosci. 1996 May 1;16(9):3056-66 [8622135] Hippocampus. 1996;6(4):347-470 [8915675] Cell. 1996 Dec 27;87(7):1339-49 [8980239] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4103-8 [9108112] Annu Rev Pharmacol Toxicol. 1998;38:321-50 [9597158] Brain Res. 1998 Jul 27;800(1):105-13 [9685600] J Neurosci. 1999 Jan 1;19(1):274-87 [9870957] Epilepsia. 1999 Sep;40(9):1210-21 [10487183] J Neurophysiol. 2004 Dec;92(6):3385-98 [15282260] J Neurosci. 2005 Jul 27;25(30):7032-9 [16049179] Nat Neurosci. 2005 Nov;8(11):1560-7 [16222227] Pharmacol Ther. 2006 Jul;111(1):224-59 [16472864] Brain. 2006 Jun;129(Pt 6):1593-608 [16632553] Exp Brain Res. 2006 Aug;173(2):322-33 [16724181] Neuron. 2006 Oct 5;52(1):155-68 [17015233] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1460-9568.2009.06896.x ER - TY - JOUR T1 - Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. AN - 67645917; 19750105 AB - Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals. We evaluated the relation between plasma PON1 status and BuChE inhibition among OP-exposed agricultural pesticide handlers. Agricultural pesticide handlers in Washington State were recruited during the 2006 and 2007 spray seasons when they were seen for follow-up ChE testing by collaborating medical providers as part of a statewide monitoring program. Blood samples were collected from 163 participants and tested for PON1 status based on plasma PON1 activity [arylesterase (AREase)] and PON1 Q192R genotype. We evaluated percent change in BuChE activity from baseline level in relation to PON1 status. We observed significantly greater BuChE inhibition among QQ homozygotes relative to RR homozygotes (p = 0.036). Lower levels of plasma PON1 activity were significantly associated with greater BuChE inhibition (p = 0.004). These associations remained after adjustment for year, days since baseline test, age, and OP exposure in the last 30 days. We found that both low PON1 catalytic efficiency (i.e., the Q192 alloform) and low plasma PON1 activity were associated with BuChE inhibition among OP-exposed agricultural pesticide handlers. Corroborative findings from future studies with prospective collection of blood samples for PON1 testing, more sensitive markers of OP-related effects, and larger sample sizes are needed. JF - Environmental health perspectives AU - Hofmann, Jonathan N AU - Keifer, Matthew C AU - Furlong, Clement E AU - De Roos, Anneclaire J AU - Farin, Federico M AU - Fenske, Richard A AU - van Belle, Gerald AU - Checkoway, Harvey AD - Department of Epidemiology, University of Washington, Seattle, Washington, USA. hofmannjn@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1402 EP - 1408 VL - 117 IS - 9 KW - Cholinesterase Inhibitors KW - 0 KW - Butyrylcholinesterase KW - EC 3.1.1.- KW - Aryldialkylphosphatase KW - EC 3.1.8.1 KW - PON1 protein, human KW - Index Medicus KW - paraoxonase KW - cholinesterase KW - agriculture KW - farmworkers KW - organophosphates KW - pesticides KW - gene-environment interaction KW - Young Adult KW - Washington KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Occupational Exposure KW - Cholinesterase Inhibitors -- pharmacology KW - Agriculture KW - Butyrylcholinesterase -- drug effects KW - Aryldialkylphosphatase -- blood KW - Butyrylcholinesterase -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67645917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Serum+cholinesterase+inhibition+in+relation+to+paraoxonase-1+%28PON1%29+status+among+organophosphate-exposed+agricultural+pesticide+handlers.&rft.au=Hofmann%2C+Jonathan+N%3BKeifer%2C+Matthew+C%3BFurlong%2C+Clement+E%3BDe+Roos%2C+Anneclaire+J%3BFarin%2C+Federico+M%3BFenske%2C+Richard+A%3Bvan+Belle%2C+Gerald%3BCheckoway%2C+Harvey&rft.aulast=Hofmann&rft.aufirst=Jonathan&rft.date=2009-09-01&rft.volume=117&rft.issue=9&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900682 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-16 N1 - Date created - 2009-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2005 Aug;86(2):291-9 [15888665] Comp Biochem Physiol B. 1974 Jul 15;48(3):427-33 [4367994] Clin Chem. 1975 Dec;21(13):1961-3 [1192590] Toxicol Appl Pharmacol. 1984 Mar 30;73(1):8-15 [6200956] Chem Biol Interact. 1993 Jun;87(1-3):35-48 [8393745] J Toxicol Environ Health. 1997 May;51(1):35-55 [9169060] Nature. 1998 Jul 16;394(6690):284-7 [9685159] Biochem Pharmacol. 1998 Aug 1;56(3):293-9 [9744565] Chem Biol Interact. 1999 May 14;119-120:503-11 [10421489] Biochem Pharmacol. 1961 Jul;7:88-95 [13726518] Clin Chim Acta. 2005 Feb;352(1-2):37-47 [15653099] Biochem Pharmacol. 2005 Feb 15;69(4):541-50 [15670573] Environ Health Perspect. 2005 Jul;113(7):909-13 [16002382] Pharmacogenet Genomics. 2005 Aug;15(8):589-98 [16007003] Pharmacogenet Genomics. 2006 Mar;16(3):183-90 [16495777] Environ Health Perspect. 2006 May;114(5):691-6 [16675422] Toxicol Appl Pharmacol. 2008 Jul 15;230(2):261-8 [18430447] Toxicol Appl Pharmacol. 2009 Feb 15;235(1):1-9 [19071155] Pharmacogenetics. 1999 Dec;9(6):745-53 [10634137] Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):516-21 [10669651] Neurotoxicology. 2000 Feb-Apr;21(1-2):91-100 [10794389] Atherosclerosis. 2000 Jun;150(2):295-8 [10856521] Pharmacogenetics. 2000 Dec;10(9):767-79 [11191881] Pharmacogenetics. 2001 Feb;11(1):77-84 [11207034] Am J Hum Genet. 2001 Jun;68(6):1428-36 [11335891] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] Hum Exp Toxicol. 2002 May;21(5):247-52 [12141395] Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1248-50 [12171781] Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1329-33 [12171796] Toxicol Lett. 2002 Aug 5;134(1-3):97-103 [12191866] Pharmacogenetics. 2003 Feb;13(2):81-8 [12563177] J Occup Environ Med. 2003 Feb;45(2):118-22 [12625227] Clin Chem. 2003 Sep;49(9):1491-7 [12928230] Annu Rev Public Health. 2004;25:155-97 [15015917] Environ Health Perspect. 2004 Jun;112(9):950-8 [15198914] Environ Health Perspect. 2005 Jul;113(7):877-82 [16002376] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900682 ER - TY - JOUR T1 - Changes in cigarette and illicit drug use among US teenagers. AN - 67641845; 19736345 JF - Archives of pediatrics & adolescent medicine AU - Lopez, Marsha F AU - Compton, Wilson M AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Blvd., Bethesda, MD 20892, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 869 EP - 870 VL - 163 IS - 9 KW - Abridged Index Medicus KW - Index Medicus KW - Adolescent Behavior KW - Humans KW - Health Surveys KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Smoking -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67641845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pediatrics+%26+adolescent+medicine&rft.atitle=Changes+in+cigarette+and+illicit+drug+use+among+US+teenagers.&rft.au=Lopez%2C+Marsha+F%3BCompton%2C+Wilson+M%3BVolkow%2C+Nora+D&rft.aulast=Lopez&rft.aufirst=Marsha&rft.date=2009-09-01&rft.volume=163&rft.issue=9&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Archives+of+pediatrics+%26+adolescent+medicine&rft.issn=1538-3628&rft_id=info:doi/10.1001%2Farchpediatrics.2009.156 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: MMWR Surveill Summ. 2008 Jun 6;57(4):1-131 [18528314] Health Psychol. 2004 May;23(3):299-307 [15099171] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archpediatrics.2009.156 ER - TY - JOUR T1 - Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. AN - 67634989; 19724244 AB - Suicidal ideation is an uncommon but worrisome symptom than can emerge during antidepressant treatment. We have described earlier the association between treatment-emergent suicidal ideation (TESI) and markers in genes encoding glutamate receptor subunits GRIK2 and GRIA3. The present genome-wide association study was conducted to identify additional genetic markers associated with TESI that may help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, and/or specialty care. A clinically representative cohort of outpatients with nonpsychotic major depressive disorder enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated with citalopram under a standard protocol for up to 14 weeks. DNA samples from 90 White participants who developed TESI and a sex-matched and race-matched equal number of treated participants who denied any suicidal ideas were genotyped with 109 365 single nucleotide polymorphisms on the Illumina's Human-1 BeadChip. One marker was found to be associated with TESI in this sample at the experiment-wide adjusted P less than 0.05 level (marker rs11628713, allelic P = 6.2x10, odds ratio = 4.7, permutation P = 0.01). A second marker was associated at the experiment-wide adjusted P = 0.06 level (rs10903034, allelic P = 3.02x10, odds ratio = 2.7, permutation P = 0.06). These markers reside within the genes PAPLN and IL28RA, respectively. PAPLN encodes papilin, a protoglycan-like sulfated glycoprotein. IL28RA encodes an interleukin receptor. Together with our earlier report, these findings may shed light on the biological basis of TESI and may help identify patients at increased risk of this potentially serious adverse event. JF - Pharmacogenetics and genomics AU - Laje, Gonzalo AU - Allen, Andrew S AU - Akula, Nirmala AU - Manji, Husseini AU - John Rush, A AU - McMahon, Francis J AD - Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. gonzalo.laje@nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 666 EP - 674 VL - 19 IS - 9 SN - 1744-6872, 1744-6872 KW - Genetic Markers KW - 0 KW - Serotonin Uptake Inhibitors KW - Citalopram KW - 0DHU5B8D6V KW - Index Medicus KW - Phenotype KW - Outpatients KW - Genotype KW - Young Adult KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Adolescent KW - Polymorphism, Single Nucleotide -- genetics KW - Pharmacogenetics KW - Citalopram -- therapeutic use KW - Depressive Disorder, Major -- drug therapy KW - Suicide -- trends KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Depressive Disorder, Major -- genetics KW - Suicide -- psychology KW - Serotonin Uptake Inhibitors -- adverse effects KW - Genome-Wide Association Study KW - Citalopram -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67634989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Genome-wide+association+study+of+suicidal+ideation+emerging+during+citalopram+treatment+of+depressed+outpatients.&rft.au=Laje%2C+Gonzalo%3BAllen%2C+Andrew+S%3BAkula%2C+Nirmala%3BManji%2C+Husseini%3BJohn+Rush%2C+A%3BMcMahon%2C+Francis+J&rft.aulast=Laje&rft.aufirst=Gonzalo&rft.date=2009-09-01&rft.volume=19&rft.issue=9&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/10.1097%2FFPC.0b013e32832e4bcd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-09-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Genetics. 2000 Jun;155(2):945-59 [10835412] Am J Psychiatry. 2007 Oct;164(10):1530-8 [17898344] Nat Immunol. 2003 Jan;4(1):8-9 [12496969] Am J Psychiatry. 2003 Apr;160(4):790-2 [12668373] Psychiatr Clin North Am. 2003 Jun;26(2):457-94, x [12778843] Biol Psychiatry. 2003 Sep 1;54(5):573-83 [12946886] Psychol Med. 2004 Jan;34(1):73-82 [14971628] Control Clin Trials. 2004 Feb;25(1):119-42 [15061154] Am J Hum Genet. 2004 Sep;75(3):424-35 [15266393] Br J Soc Clin Psychol. 1967 Dec;6(4):278-96 [6080235] Am J Psychiatry. 1990 Feb;147(2):207-10 [2301661] J Hepatol. 1994 Aug;21(2):241-3 [7989716] N Engl J Med. 1997 Sep 25;337(13):910-5 [9302306] J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [14399272] Neuropsychopharmacology. 2005 Feb;30(2):405-16 [15578008] Drug Saf. 2005;28(12):1151-7 [16329717] Am J Psychiatry. 2006 Jan;163(1):28-40 [16390886] Biol Psychiatry. 2006 Mar 15;59(6):493-501 [16199008] Am J Hum Genet. 2006 May;78(5):804-14 [16642436] Arch Gen Psychiatry. 2007 Jun;64(6):689-97 [17548750] Am J Psychiatry. 2007 Sep;164(9):1356-63 [17728420] Am J Hum Genet. 2000 Jul;67(1):170-81 [10827107] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/FPC.0b013e32832e4bcd ER - TY - JOUR T1 - p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. AN - 67631617; 19701195 AB - The finite proliferative potential of normal human cells leads to replicative cellular senescence, which is a critical barrier to tumour progression in vivo. We show that the human p53 isoforms Delta133p53 and p53beta function in an endogenous regulatory mechanism for p53-mediated replicative senescence. Induced p53beta and diminished Delta133p53 were associated with replicative senescence, but not oncogene-induced senescence, in normal human fibroblasts. The replicatively senescent fibroblasts also expressed increased levels of miR-34a, a p53-induced microRNA, the antisense inhibition of which delayed the onset of replicative senescence. The siRNA (short interfering RNA)-mediated knockdown of endogenous Delta133p53 induced cellular senescence, which was attributed to the regulation of p21(WAF1) and other p53 transcriptional target genes. In overexpression experiments, whereas p53beta cooperated with full-length p53 to accelerate cellular senescence, Delta133p53 repressed miR-34a expression and extended the cellular replicative lifespan, providing a functional connection of this microRNA to the p53 isoform-mediated regulation of senescence. The senescence-associated signature of p53 isoform expression (that is, elevated p53beta and reduced Delta133p53) was observed in vivo in colon adenomas with senescent phenotypes. The increased Delta133p53 and decreased p53beta isoform expression found in colon carcinoma may signal an escape from the senescence barrier during the progression from adenoma to carcinoma. JF - Nature cell biology AU - Fujita, Kaori AU - Mondal, Abdul M AU - Horikawa, Izumi AU - Nguyen, Giang H AU - Kumamoto, Kensuke AU - Sohn, Jane J AU - Bowman, Elise D AU - Mathe, Ewy A AU - Schetter, Aaron J AU - Pine, Sharon R AU - Ji, Helen AU - Vojtesek, Borivoj AU - Bourdon, Jean-Christophe AU - Lane, David P AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1135 EP - 1142 VL - 11 IS - 9 KW - MIRN34 microRNA, human KW - 0 KW - MicroRNAs KW - Protein Isoforms KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Gene Knockdown Techniques KW - Colonic Neoplasms -- genetics KW - MicroRNAs -- metabolism KW - Protein Isoforms -- metabolism KW - Humans KW - Mutation -- genetics KW - Colonic Neoplasms -- metabolism KW - Cell Line, Tumor KW - Protein Isoforms -- genetics KW - Cell Aging KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67631617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+cell+biology&rft.atitle=p53+isoforms+Delta133p53+and+p53beta+are+endogenous+regulators+of+replicative+cellular+senescence.&rft.au=Fujita%2C+Kaori%3BMondal%2C+Abdul+M%3BHorikawa%2C+Izumi%3BNguyen%2C+Giang+H%3BKumamoto%2C+Kensuke%3BSohn%2C+Jane+J%3BBowman%2C+Elise+D%3BMathe%2C+Ewy+A%3BSchetter%2C+Aaron+J%3BPine%2C+Sharon+R%3BJi%2C+Helen%3BVojtesek%2C+Borivoj%3BBourdon%2C+Jean-Christophe%3BLane%2C+David+P%3BHarris%2C+Curtis+C&rft.aulast=Fujita&rft.aufirst=Kaori&rft.date=2009-09-01&rft.volume=11&rft.issue=9&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=Nature+cell+biology&rft.issn=1476-4679&rft_id=info:doi/10.1038%2Fncb1928 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2008 Mar 6;27(11):1562-71 [17873905] Cell. 2008 Feb 8;132(3):363-74 [18267069] Cancer Res. 2008 May 1;68(9):3193-203 [18451145] Cell. 2008 Jun 13;133(6):1006-18 [18555777] Cell. 2008 Jun 13;133(6):1019-31 [18555778] Oncogene. 2008 Sep 4;27(39):5204-13 [18504438] Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13421-6 [18755897] Genes Dev. 2009 Feb 1;23(3):278-90 [19204115] Mol Cell Biol. 2000 Apr;20(8):2803-8 [10733583] Gastroenterology. 2000 Oct;119(4):929-42 [11040180] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Mol Cell. 2004 May 21;14(4):501-13 [15149599] Carcinogenesis. 1980 May;1(5):375-80 [7273277] Nature. 1990 Aug 30;346(6287):866-8 [2392154] Cell. 1992 Sep 18;70(6):937-48 [1525830] Exp Gerontol. 1992 Jul-Aug;27(4):375-82 [1459213] Hum Mol Genet. 1995 Feb;4(2):313-4 [7757087] Cell. 1997 Mar 7;88(5):593-602 [9054499] Science. 1997 Aug 8;277(5327):831-4 [9242615] Cell. 1998 Feb 6;92(3):401-13 [9476899] J Biol Chem. 1998 May 15;273(20):11995-8 [9575138] J Clin Invest. 2004 Nov;114(9):1299-307 [15520862] J Cell Sci. 2005 Feb 1;118(Pt 3):485-96 [15657080] Nature. 2005 Aug 4;436(7051):642 [16079833] Genes Dev. 2005 Sep 15;19(18):2122-37 [16131611] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):573-7 [16537718] Nat Cell Biol. 2006 Aug;8(8):877-84 [16862142] Nature. 2006 Nov 30;444(7119):633-7 [17136093] Cell Death Differ. 2007 Jan;14(1):3-9 [17068503] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8334-9 [17488820] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Mol Cell. 2007 Jun 8;26(5):745-52 [17540599] Nature. 2007 Jun 28;447(7148):1130-4 [17554337] Cell. 2007 Jul 27;130(2):223-33 [17662938] Curr Biol. 2007 Aug 7;17(15):1298-307 [17656095] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7 [17875987] Oncogene. 2007 Nov 15;26(52):7302-12 [17533371] Cancer Res. 2007 Dec 15;67(24):11677-86 [18089797] JAMA. 2008 Jan 30;299(4):425-36 [18230780] Science. 2008 Mar 7;319(5868):1352-5 [18323444] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ncb1928 ER - TY - JOUR T1 - The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. AN - 67629314; 19587094 AB - Prostaglandin E(2) (PGE(2)) is elevated in many tumor types, but PGE(2)'s contributions to tumor growth are largely unknown. To investigate PGE(2)'s roles, the contributions of one of its receptors, EP2, were studied using the mouse skin initiation/promotion model. Initial studies indicated that protein kinase A (PKA), epidermal growth factor receptor (EGFR) and several effectors-cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB), H-Ras, Src, protein kinase B (AKT) and extracellular signal-regulated kinase (ERK)1/2-were activated in 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted papillomas and that PKA and EGFR inhibition (H89 and AG1478, respectively) decreased papilloma formation. EP2's contributions to the activation of these pathways and papilloma development were determined by inhibiting endogenous TPA-induced PGE(2) production with indomethacin (Indo) and concomitantly treating with the EP2 agonist, CAY10399 (CAY). CAY treatment restored papilloma formation in TPA/Indo-treated mice and increased cyclic adenosine 3',5'-monophosphate and PKA activation as measured by p-CREB formation. CAY treatment also increased EGFR and Src activation and their inhibition by AG1478 and PP2 indicated that Src was upstream of EGFR. CAY also increased H-Ras, ERK1/2 and AKT activation, and AG1478 decreased their activation indicating EGFR being upstream. Supporting EP2's contribution, EP2-/- mice exhibited 65% fewer papillomas and reduced Src, EGFR, H-Ras, AKT and ERK1/2 activation. G protein-coupled receptor (GPCR) activation of EGFR has been reported to involve Src's activation via a GPCR-beta-arrestin-Src complex. Indeed, immunoprecipitation of beta-arrestin1 or p-Src indicated the presence of an EP2-beta-arrestin1-p-Src complex in papillomas. The data indicated that EP2 contributed to tumor formation via activation of PKA and EGFR and that EP2 formed a complex with beta-arrestin1 and Src that contributed to signaling and/or EP2 desensitization. JF - Carcinogenesis AU - Chun, Kyung-Soo AU - Lao, Huei-Chen AU - Trempus, Carol S AU - Okada, Manabu AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1620 EP - 1627 VL - 30 IS - 9 KW - Arrestins KW - 0 KW - Ptger2 protein, mouse KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP2 Subtype KW - beta-Arrestins KW - Cyclic AMP KW - E0399OZS9N KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - src-Family Kinases KW - EC 2.7.10.2 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Tetradecanoylphorbol Acetate -- toxicity KW - Cyclic AMP-Dependent Protein Kinases -- physiology KW - Mice KW - Receptor, Epidermal Growth Factor -- physiology KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Genes, ras KW - src-Family Kinases -- metabolism KW - Cyclic AMP -- metabolism KW - Mice, Inbred C57BL KW - Female KW - Signal Transduction -- physiology KW - Papilloma -- etiology KW - Skin Neoplasms -- etiology KW - Receptors, Prostaglandin E -- physiology KW - Skin Neoplasms -- metabolism KW - Papilloma -- metabolism KW - Arrestins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67629314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+prostaglandin+receptor+EP2+activates+multiple+signaling+pathways+and+beta-arrestin1+complex+formation+during+mouse+skin+papilloma+development.&rft.au=Chun%2C+Kyung-Soo%3BLao%2C+Huei-Chen%3BTrempus%2C+Carol+S%3BOkada%2C+Manabu%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2009-09-01&rft.volume=30&rft.issue=9&rft.spage=1620&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp168 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Carcinog. 2007 Dec;46(12):958-70 [17477350] Mol Carcinog. 2007 Nov;46(11):912-23 [17427962] Mol Cancer Res. 2008 Jun;6(6):1003-16 [18567804] Mol Carcinog. 1999 Nov;26(3):150-6 [10559789] Annu Rev Biochem. 2000;69:145-82 [10966456] Mol Pharmacol. 2000 Dec;58(6):1279-86 [11093764] Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609 [11483993] J Biol Chem. 2001 Aug 31;276(35):32648-56 [11418617] Cancer Res. 2002 Jan 1;62(1):28-32 [11782353] Oncogene. 2002 Jan 3;21(1):53-64 [11791176] Cancer Res. 2002 Jan 15;62(2):506-11 [11809702] Mol Carcinog. 2002 Mar;33(3):146-55 [11870880] Nat Med. 2002 Mar;8(3):289-93 [11875501] Cancer Res. 2002 Jun 15;62(12):3395-401 [12067981] J Environ Pathol Toxicol Oncol. 2002;21(2):183-91 [12086405] Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12483-8 [12221288] Mol Med. 2002 Oct;8(10):624-37 [12477973] Trends Pharmacol Sci. 2003 Jul;24(7):335-40 [12871665] J Biol Chem. 2003 Sep 12;278(37):35451-7 [12824187] Life Sci. 2003 Dec 5;74(2-3):143-53 [14607241] Pharmacol Ther. 2004 Aug;103(2):147-66 [15369681] Oncogene. 2004 Oct 18;23(48):7969-78 [15489914] Carcinogenesis. 1984 Mar;5(3):301-7 [6323045] Carcinogenesis. 1986 Sep;7(9):1599-602 [2427243] Cancer Res. 1994 Mar 1;54(5):1178-89 [8118803] Cancer Res. 1997 Aug 1;57(15):3180-8 [9242447] Nat Med. 1999 Feb;5(2):217-20 [9930871] Carcinogenesis. 2005 Feb;26(2):353-7 [15564292] Cancer Res. 2005 Mar 1;65(5):1822-9 [15753380] Cancer Res. 2005 May 1;65(9):3958-65 [15867397] Cancer Res. 2005 Jun 1;65(11):4496-9 [15930264] Mol Pharmacol. 2005 Jul;68(1):251-9 [15855407] Semin Cancer Biol. 2005 Dec;15(6):460-73 [16039870] Cancer Res. 2005 Oct 15;65(20):9304-11 [16230392] Cancer Cell. 2005 Nov;8(5):381-92 [16286246] Carcinogenesis. 2005 Dec;26(12):2116-22 [16051640] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1492-7 [16432186] Gene. 2006 Jan 17;366(1):2-16 [16377102] Cancer Res. 2006 Mar 1;66(5):2700-7 [16510590] Oncogene. 2006 Sep 7;25(40):5507-16 [16607275] J Invest Dermatol. 2007 Feb;127(2):439-46 [16977324] Annu Rev Physiol. 2007;69:483-510 [17305471] Cancer Res. 2007 Mar 1;67(5):2015-21 [17332329] FASEB J. 2007 Aug;21(10):2418-30 [17384145] J Clin Invest. 2007 Sep;117(9):2445-58 [17786238] Mol Biotechnol. 2008 Jul;39(3):239-64 [18240029] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp168 ER - TY - JOUR T1 - Differential alterations in metabolic pattern of the spliceosomal uridylic acid-rich small nuclear RNAs (UsnRNAs) during malignant transformation of 20-methylcholanthrene-induced mouse CNCI-PM-20 embryonic fibroblasts. AN - 67627558; 19496104 AB - Differential alterations of the spliceosomal Uridylic acid rich small nuclear RNAs (UsnRNAs) (U1, U2, U4, U5, and U6) are reported to be associated with cellular proliferation and development, but definitive information is scarce and also elusive. An attempt is made in this study to analyze the metabolic patterns of major spliceosomal UsnRNAs, during tumor development, in an in vitro carcinogenesis model of 20-methylcholanthrene (MCA)-transformed Swiss Mouse Embryonic Fibroblast (MEF), designated as CNCI-PM-20. MEF cells, after treatment with 20-MCA, progressed through a sequence of passages with distinct and heritable changes, finally becoming neoplastic at passage-42 (P42). A differential expression pattern of major UsnRNAs was observed during this process. The abundance of U1 was 20% below control (P1) at passage-20 (P20), followed by a gradual increase up until P42 (approximately 12% above the P1 value). The abundance of U2 was more or less constant during the cellular transformation. U4 showed a trend of increase, with above 30% abundance than control at P20, followed by a significant increase at P36 and P42 (1.5- and 2-fold, respectively, P-value <0.01). U5 also followed an identical pattern, with an increase of 70% compared to control (P-value <0.05) at P42. Interestingly, U6 gradually decreased from P20 onwards up until P42, with 22% at P20 and 67% at P42 (P-value <0.01). An overall significant quantitative alteration in abundance of U4, U5, and U6, observed in our study, contributes to the understanding of the fact that, the metabolism of major spliceosomal UsnRNAs is differentially regulated during the process of neoplastic transformation. JF - Molecular carcinogenesis AU - Mukherjee, Sudeshna AU - Manna, Sugata AU - Mukherjee, Pratima AU - Panda, Chinmay K AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata 700026, India. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 773 EP - 778 VL - 48 IS - 9 KW - RNA, Small Nuclear KW - 0 KW - U1 small nuclear RNA KW - U2 small nuclear RNA KW - U4 small nuclear RNA KW - U5 small nuclear RNA KW - U6 small nuclear RNA KW - Methylcholanthrene KW - 56-49-5 KW - Uridine Monophosphate KW - E2OU15WN0N KW - Index Medicus KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Animals KW - Uridine Monophosphate -- metabolism KW - Spliceosomes -- metabolism KW - Cells, Cultured KW - Embryo, Mammalian -- cytology KW - Spliceosomes -- genetics KW - Mice KW - Spliceosomes -- drug effects KW - Fibroblasts -- drug effects KW - RNA, Small Nuclear -- metabolism KW - Methylcholanthrene -- toxicity KW - Cell Transformation, Neoplastic -- drug effects KW - Fibroblasts -- cytology KW - RNA, Small Nuclear -- genetics KW - Fibroblasts -- metabolism KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67627558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Differential+alterations+in+metabolic+pattern+of+the+spliceosomal+uridylic+acid-rich+small+nuclear+RNAs+%28UsnRNAs%29+during+malignant+transformation+of+20-methylcholanthrene-induced+mouse+CNCI-PM-20+embryonic+fibroblasts.&rft.au=Mukherjee%2C+Sudeshna%3BManna%2C+Sugata%3BMukherjee%2C+Pratima%3BPanda%2C+Chinmay+K&rft.aulast=Mukherjee&rft.aufirst=Sudeshna&rft.date=2009-09-01&rft.volume=48&rft.issue=9&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20556 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20556 ER - TY - JOUR T1 - Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. AN - 67622000; 19445939 AB - Epstein-Barr virus (EBV) has been causally associated with cancer; some gastric carcinomas have a monoclonal EBV genome in every cancer cell, indicating that they arose from a single infected progenitor cell. However, the proportion of EBV-positive gastric carcinomas is uncertain, and the etiologic significance is unknown. We conducted a meta-analysis of 70 studies including 15,952 cases of gastric cancer assessed by in situ hybridization for EBV-encoded small RNA. The pooled prevalence estimate of EBV positivity was 8.7% (95% confidence interval [CI]: 7.5%-10.0%) overall, with a 2-fold difference by sex: 11.1% (95% CI: 8.7%-14.1%) of gastric cancer cases in males vs 5.2% (95% CI: 3.6%-7.4%) of cases in females. Tumors arising in the gastric cardia (13.6%) or corpus (13.1%) were more than twice as likely to be EBV-positive as those in the antrum (5.2%; P < .01 for both comparisons). EBV prevalence was 4 times higher (35.1%) for tumors in postsurgical gastric stump/remnants. Over 90% of lymphoepithelioma-like carcinomas were EBV positive, but only 15 studies reported any cases of this type; prevalence did not significantly differ between the more common diffuse (9.5%) [corrected] and intestinal (7.6%) [corrected] histologies. EBV prevalence was similar in cases from Asia (8.3%), Europe (9.2%), and the Americas (9.9%). EBV-positive gastric cancers greatly differ from other gastric carcinomas based on sex, anatomic subsite, and surgically disrupted anatomy, indicating that it is a distinct etiologic entity. Epidemiologic studies comparing EBV-positive and -negative gastric cancers are warranted to investigate EBV's role in gastric carcinogenesis. JF - Gastroenterology AU - Murphy, Gwen AU - Pfeiffer, Ruth AU - Camargo, M Constanza AU - Rabkin, Charles S AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Rockville, Maryland 20892, USA. murphygw@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 824 EP - 833 VL - 137 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Carcinoma -- virology KW - Pyloric Antrum -- virology KW - Sex Factors KW - Gastric Stump KW - Humans KW - Cardia -- virology KW - Adenocarcinoma -- virology KW - Male KW - Female KW - Epstein-Barr Virus Infections -- complications KW - Stomach Neoplasms -- pathology KW - Stomach Neoplasms -- surgery KW - Stomach Neoplasms -- virology KW - Herpesvirus 4, Human -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67622000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Meta-analysis+shows+that+prevalence+of+Epstein-Barr+virus-positive+gastric+cancer+differs+based+on+sex+and+anatomic+location.&rft.au=Murphy%2C+Gwen%3BPfeiffer%2C+Ruth%3BCamargo%2C+M+Constanza%3BRabkin%2C+Charles+S&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2009-09-01&rft.volume=137&rft.issue=3&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2009.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Clin Cancer Res. 2005 Sep;24(3):379-85 [16270524] World J Gastroenterol. 2005 Oct 21;11(39):6096-103 [16273633] J Exp Clin Cancer Res. 2005 Dec;24(4):547-53 [16471317] World J Gastroenterol. 2006 Mar 28;12(12):1842-8 [16609989] J Med Microbiol. 2006 Jul;55(Pt 7):905-11 [16772418] Int J Epidemiol. 2006 Oct;35(5):1270-1 [16980313] Am J Epidemiol. 2007 Jun 15;165(12):1424-33 [17420181] Nature. 2000 Mar 23;404(6776):398-402 [10746728] Gastroenterology. 2000 Jun;118(6):1031-8 [10833477] Pathol Int. 2000 Jun;50(6):486-92 [10886725] Am J Clin Pathol. 2000 Sep;114(3):354-63 [10989635] Mol Pathol. 2000 Oct;53(5):255-61 [11091849] Eur J Cancer Prev. 2001 Feb;10(1):69-75 [11263593] Jpn J Cancer Res. 2001 Sep;92(9):911-7 [11572757] Int J Cancer. 2001 Nov15;94(4):527-30 [11745439] Br J Cancer. 2002 Mar 4;86(5):702-4 [11875729] Scand J Gastroenterol. 2002 Jul;37(7):825-9 [12190097] J Clin Pathol. 2002 Sep;55(9):669-75 [12194996] J Med Virol. 2002 Nov;68(3):384-9 [12226826] Science. 2002 Sep 20;297(5589):2008-9 [12242430] Gastric Cancer. 2002;5(4):213-9 [12491079] J Pathol. 2003 Feb;199(2):140-5 [12533825] J Pathol. 2003 Apr;199(4):447-52 [12635135] Arch Pathol Lab Med. 2003 Apr;127(4):478-80 [12683879] Mod Pathol. 2003 Jul;16(7):641-51 [12861059] Gastric Cancer. 2003;6(3):173-8 [14520531] J Clin Oncol. 2004 Feb 15;22(4):664-70 [14966089] J Infect Dis. 2004 Jun 15;189(12):2271-81 [15181575] Oncol Rep. 2004 Nov;12(5):1093-8 [15492798] Nat Rev Cancer. 2004 Oct;4(10):757-68 [15510157] IARC Sci Publ. 1978;(20):167-89 [215514] Arch Surg. 1982 Mar;117(3):294-7 [7065870] Control Clin Trials. 1986 Sep;7(3):177-88 [3802833] Mod Pathol. 1990 May;3(3):377-80 [2163534] Am J Pathol. 1992 Apr;140(4):769-74 [1314023] Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5455-9 [8390666] Am J Pathol. 1993 Nov;143(5):1250-4 [8238241] Lab Invest. 1994 Jul;71(1):73-81 [8041121] Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9131-5 [8090780] Am J Surg Pathol. 1994 Nov;18(11):1158-63 [7943537] J Clin Pathol. 1994 Aug;47(8):695-8 [7962618] Oncogene. 1995 Feb 2;10(3):549-60 [7845680] Mol Cell Biol. 1996 Mar;16(3):952-9 [8622698] Am J Clin Pathol. 1996 Feb;105(2):174-81 [8607441] Histopathology. 1996 Feb;28(2):121-7 [8834519] Int J Cancer. 1997 Feb 7;70(4):375-82 [9033642] Jpn J Cancer Res. 1997 Mar;88(3):262-6 [9140110] Pathol Int. 1997 Jun;47(6):360-7 [9211523] BMJ. 1998 May 16;316(7143):1507-10 [9582144] IARC Monogr Eval Carcinog Risks Hum. 1997;70:47-373 [9612712] Oral Oncol. 1998 Jan;34(1):15-23 [9659515] Pathol Res Pract. 1998;194(10):705-11 [9820867] J Clin Pathol. 1998 Sep;51(9):662-6 [9930069] Am J Gastroenterol. 1999 Jun;94(6):1582-6 [10364028] Hepatogastroenterology. 1999 Mar-Apr;46(26):1214-9 [10370694] J Clin Gastroenterol. 1999 Jul;29(1):39-43 [10405229] Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15730-5 [15498875] Acta Pathol Microbiol Scand. 1965;64:31-49 [14320675] Gut. 2007 Jul;56(7):918-25 [17317788] Gut. 2007 Dec;56(12):1671-7 [17627962] World J Gastroenterol. 2008 Feb 14;14(6):884-91 [18240345] Cancer Sci. 2008 Feb;99(2):195-201 [18271915] Aging Clin Exp Res. 2008 Apr;20(2):91-102 [18431075] Hepatogastroenterology. 2008 Jan-Feb;55(81):41-5 [18507075] Scand J Gastroenterol. 2008;43(6):669-74 [18569983] World J Gastroenterol. 2008 Jul 21;14(27):4347-51 [18666324] Int J Epidemiol. 2008 Oct;37(5):1158-60 [18832388] Gut. 2009 Jan;58(1):16-23 [18838486] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] J Gastroenterol. 2005 Jun;40(6):570-7 [16007390] Erratum In: Gastroenterology. 2011 Mar;140(3):1109 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2009.05.001 ER - TY - JOUR T1 - Assessment of kidney function for drug dosing. AN - 67617178; 19589844 JF - Clinical chemistry AU - Narva, Andrew S AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0001, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1609 EP - 1611 VL - 55 IS - 9 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Pharmacology KW - Pharmaceutical Preparations -- chemistry KW - Humans KW - Kidney Diseases -- chemically induced KW - Kidney -- physiology KW - Kidney -- drug effects KW - Drug Dosage Calculations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67617178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Assessment+of+kidney+function+for+drug+dosing.&rft.au=Narva%2C+Andrew+S&rft.aulast=Narva&rft.aufirst=Andrew&rft.date=2009-09-01&rft.volume=55&rft.issue=9&rft.spage=1609&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2009.127944 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2009.127944 ER - TY - JOUR T1 - Ethical considerations for administering alcohol or alcohol cues to treatment-seeking alcoholics in a research setting: can the benefits to society outweigh the risks to the individual? A commentary in the context of the National Advisory Council on Alcohol Abuse and Alcoholism -- Recommended Council Guidelines on Ethyl Alcohol Administration in Human Experimentation (2005). AN - 67613222; 19519721 JF - Alcoholism, clinical and experimental research AU - Enoch, Mary-Anne AU - Johnson, Kenneth AU - George, David T AU - Schumann, Gunter AU - Moss, Howard B AU - Kranzler, Henry R AU - Goldman, David AU - National Advisory Council on Alcohol Abuse and Alcoholism AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892-9412, USA. maenoch@niaaa.nih.gov ; National Advisory Council on Alcohol Abuse and Alcoholism Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1508 EP - 1512 VL - 33 IS - 9 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Harm Reduction KW - Humans KW - Cues KW - Recovery of Function KW - Informed Consent KW - Temperance KW - Risk Assessment KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Human Experimentation -- ethics KW - Ethics, Research KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67613222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Ethical+considerations+for+administering+alcohol+or+alcohol+cues+to+treatment-seeking+alcoholics+in+a+research+setting%3A+can+the+benefits+to+society+outweigh+the+risks+to+the+individual%3F+A+commentary+in+the+context+of+the+National+Advisory+Council+on+Alcohol+Abuse+and+Alcoholism+--+Recommended+Council+Guidelines+on+Ethyl+Alcohol+Administration+in+Human+Experimentation+%282005%29.&rft.au=Enoch%2C+Mary-Anne%3BJohnson%2C+Kenneth%3BGeorge%2C+David+T%3BSchumann%2C+Gunter%3BMoss%2C+Howard+B%3BKranzler%2C+Henry+R%3BGoldman%2C+David%3BNational+Advisory+Council+on+Alcohol+Abuse+and+Alcoholism&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2009-09-01&rft.volume=33&rft.issue=9&rft.spage=1508&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2009.00988.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-16 N1 - Date created - 2009-08-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Psychol Addict Behav. 2000 Dec;14(4):315-8 [11130150] Alcohol Clin Exp Res. 2008 Jul;32(7):1321-8 [18540908] Addict Behav. 2002 Nov-Dec;27(6):867-86 [12369473] Neuropsychopharmacology. 2003 Aug;28(8):1546-52 [12813472] Br J Addict. 1990 Jan;85(1):119-23 [2310844] Alcohol Alcohol. 1993 Mar;28(2):189-97 [8517890] Addiction. 1997 Sep;92(9):1087-97 [9374005] Alcohol Clin Exp Res. 2004 Dec;28(12):1789-95 [15608594] Alcohol. 2005 Jun;36(2):19-26 [16440475] Can J Commun Ment Health. 2005 Spring;24(1):95-113 [16568624] Alcohol. 2005 Nov;37(3):135-41 [16713501] J Clin Psychopharmacol. 2006 Dec;26(6):610-25 [17110818] Alcohol Clin Exp Res. 2007 Apr;31(4):555-63 [17374034] Alcohol Res Health. 2006;29(4):286-90 [17718408] J Clin Psychopharmacol. 2007 Oct;27(5):507-12 [17873686] Drug Alcohol Depend. 2007 Dec 1;91(2-3):149-58 [17597309] Alcohol Clin Exp Res. 2007 Dec;31(12):2036-45 [18034696] Am J Addict. 2008 Jan-Feb;17(1):70-6 [18214726] Arch Gen Psychiatry. 2008 Feb;65(2):135-44 [18250251] Science. 2008 Mar 14;319(5869):1536-9 [18276852] Psychol Addict Behav. 2000 Dec;14(4):319-27 [11155893] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1530-0277.2009.00988.x ER - TY - JOUR T1 - The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis. AN - 67611525; 19545276 AB - The dynamic process of pathogen transmission by the bite of an insect vector combines several biological processes that have undergone extensive co-evolution. Whereas the host response to an insect bite is only occasionally confronted with the parasitic pathogens that competent vectors might transmit, the transmitted parasites will always be confronted with the acute, wound-healing response that is initiated by the bite itself. Invariably, this response involves neutrophils. In the case of Leishmania, infection is initiated in the skin following the bite of an infected sand fly, suggesting that Leishmania must possess some means to survive their early encounter with recruited neutrophils at the bite site. Here, we review the literature regarding the impact of neutrophils on the outcome of infection with Leishmania, with special attention to the role of the sand fly bite. JF - Cellular microbiology AU - Peters, Nathan C AU - Sacks, David L AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. NPeters@niaid.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1290 EP - 1296 VL - 11 IS - 9 KW - Index Medicus KW - Animals KW - Psychodidae KW - Humans KW - Insect Vectors -- parasitology KW - Insect Bites and Stings -- immunology KW - Leishmaniasis, Cutaneous -- immunology KW - Leishmaniasis, Cutaneous -- transmission KW - Leishmania -- immunology KW - Neutrophil Infiltration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67611525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=The+impact+of+vector-mediated+neutrophil+recruitment+on+cutaneous+leishmaniasis.&rft.au=Peters%2C+Nathan+C%3BSacks%2C+David+L&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2009-09-01&rft.volume=11&rft.issue=9&rft.spage=1290&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=1462-5822&rft_id=info:doi/10.1111%2Fj.1462-5822.2009.01348.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-15 N1 - Date created - 2009-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2006 Sep 15;177(6):4047-54 [16951368] Curr Opin Hematol. 2006 Jan;13(1):28-33 [16319684] EMBO J. 2006 Oct 4;25(19):4628-37 [16977314] J Immunol. 2006 Oct 15;177(8):5269-77 [17015712] Parasitology. 2006;132 Suppl:S61-8 [17018166] Autoimmunity. 2007 Jun;40(4):349-52 [17516227] J Leukoc Biol. 2007 Aug;82(2):288-99 [17449725] Am J Pathol. 2007 Sep;171(3):928-37 [17690184] J Immunol. 2007 Sep 15;179(6):3988-94 [17785837] Immunol Rev. 2007 Oct;219:88-102 [17850484] Immunol Rev. 2007 Oct;219:103-17 [17850485] Infect Immun. 2008 Feb;76(2):532-41 [18056477] Eur J Immunol. 2008 Feb;38(2):437-47 [18203135] Immunobiology. 2008;213(3-4):183-91 [18406366] J Leukoc Biol. 2008 Aug;84(2):389-96 [18483206] Science. 2008 Aug 15;321(5891):970-4 [18703742] PLoS Pathog. 2008 Nov;4(11):e1000222 [19043558] J Infect Dis. 2005 Sep 15;192(6):1127-34 [16107969] Parasitol Int. 2005 Jun;54(2):109-18 [15866472] J Immunol. 2005 Dec 15;175(12):8346-53 [16339576] J Leukoc Biol. 2006 May;79(5):977-88 [16501052] Arthritis Res Ther. 2006;8 Suppl 1:S3 [16820042] Microbes Infect. 2006 Jun;8(7):1801-5 [16822690] J Exp Med. 2009 Mar 16;206(3):577-93 [19273622] J Immunol. 2007 Apr 15;178(8):5109-15 [17404293] Nature. 2000 Jan 13;403(6766):199-203 [10646605] J Exp Med. 2000 Feb 7;191(3):411-6 [10662786] J Immunol. 2000 Jul 15;165(2):969-77 [10878373] J Immunol. 2000 Sep 1;165(5):2628-36 [10946291] Infect Immun. 2002 Feb;70(2):826-35 [11796617] J Immunol. 2002 Feb 15;168(4):1627-35 [11823490] Nature. 2002 May 2;417(6884):91-4 [12018205] J Immunol. 2002 Jul 15;169(2):898-905 [12097394] Trends Microbiol. 2003 May;11(5):210-4 [12781523] Arthritis Rheum. 2003 Aug;48(8):2362-74 [12905492] J Immunol. 2003 Dec 1;171(11):6052-8 [14634118] Lancet. 2004 Feb 28;363(9410):696-703 [15001327] J Immunol. 2004 Apr 1;172(7):4454-62 [15034061] Am J Trop Med Hyg. 1981 Mar;30(2):322-33 [7235125] J Immunol. 1981 Oct;127(4):1438-43 [7276565] Am J Pathol. 1984 Jan;114(1):137-48 [6691411] J Biol Chem. 1984 Sep 25;259(18):11173-5 [6088532] Parasite Immunol. 1984 Sep;6(5):397-408 [6504555] J Parasitol. 1987 Feb;73(1):55-63 [3572666] J Submicrosc Cytol. 1987 Jul;19(3):387-95 [3612880] J Med Microbiol. 1990 Jul;32(3):189-93 [2374156] Parasite Immunol. 1990 May;12(3):285-95 [2385444] J Leukoc Biol. 1992 Aug;52(2):135-42 [1506767] J Immunol. 1993 Nov 1;151(9):4891-901 [8409447] Int J Exp Pathol. 1996 Feb;77(1):15-24 [8664142] Immunol Lett. 1998 Dec;64(2-3):145-51 [9870666] J Immunol. 2004 Dec 1;173(11):6521-5 [15557140] Annu Rev Immunol. 2005;23:197-223 [15771570] Nat Clin Pract Rheumatol. 2006 Sep;2(9):500-10 [16951705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1462-5822.2009.01348.x ER - TY - JOUR T1 - Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex. AN - 67596462; 19641134 AB - The serine-threonine kinase RIP1 was originally identified through its ability to bind to the death domain of Fas (CD95). RIP1 has been shown to be recruited to the Fas death-inducing signaling complex (DISC) and is required for the induction of necrotic cell death. In this study, we show that in Jurkat T lymphocytes, RIP1 is also necessary for the most efficient activation of downstream caspases by Fas when treated with membrane-bound Fas ligand, but not with agonistic Abs or cross-linked soluble Fas ligand. RIP1 participates in the Fas-associated death domain protein-mediated recruitment of caspase-8 to the Fas receptor complex in a manner that promotes caspase-8 activation. Cross-linking Abs, such as CH11, bypass the requirement for RIP1 in caspase activation by initiating larger, though less efficient, DISC complexes, while membrane-bound Fas ligand initiates a smaller but more efficient DISC that functions, in part, by effectively incorporating more RIP1 into the complex. Consequently, RIP1 is likely a more integral part of physiological signaling through the Fas/CD95 receptor complex than previously recognized; at least when the signal is mediated by full-length membrane-bound FasL. Cross-linked soluble FasL, which also occurs physiologically, behaves similarly to the CH11 Ab, and may therefore be more likely to initiate nonapoptotic Fas signaling due to less RIP1 in the receptor complex. Thus, agonists that bind the same Fas receptor initiate mechanistically distinct pathways resulting in differential cytotoxicity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Morgan, Michael J AU - Kim, You-Sun AU - Liu, Zheng-gang AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. morganmi@mail.nih.gov Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 3278 EP - 3284 VL - 183 IS - 5 KW - AGFG1 protein, human KW - 0 KW - Antibodies KW - Antigens, CD95 KW - Cross-Linking Reagents KW - Death Domain Receptor Signaling Adaptor Proteins KW - Fas Ligand Protein KW - Immunoglobulin M KW - Membrane Proteins KW - Nuclear Pore Complex Proteins KW - Oligopeptides KW - Peptides KW - RNA-Binding Proteins KW - FLAG peptide KW - 98849-88-8 KW - CASP8 protein, human KW - EC 3.4.22.- KW - Caspase 8 KW - Abridged Index Medicus KW - Index Medicus KW - Immunoglobulin M -- metabolism KW - Humans KW - Jurkat Cells KW - Peptides -- immunology KW - Cross-Linking Reagents -- metabolism KW - Immunity, Innate KW - Antigens, CD95 -- agonists KW - Cell Death -- immunology KW - Antigens, CD95 -- immunology KW - Cytotoxicity, Immunologic KW - Antigens, CD95 -- metabolism KW - Antibodies -- metabolism KW - Enzyme Activation -- immunology KW - Caspase 8 -- metabolism KW - Fas Ligand Protein -- toxicity KW - RNA-Binding Proteins -- metabolism KW - Membrane Proteins -- immunology KW - Membrane Proteins -- metabolism KW - Nuclear Pore Complex Proteins -- metabolism KW - RNA-Binding Proteins -- physiology KW - Nuclear Pore Complex Proteins -- deficiency KW - Membrane Proteins -- toxicity KW - Fas Ligand Protein -- immunology KW - Death Domain Receptor Signaling Adaptor Proteins -- metabolism KW - Fas Ligand Protein -- metabolism KW - Nuclear Pore Complex Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67596462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Membrane-bound+Fas+ligand+requires+RIP1+for+efficient+activation+of+caspase-8+within+the+death-inducing+signaling+complex.&rft.au=Morgan%2C+Michael+J%3BKim%2C+You-Sun%3BLiu%2C+Zheng-gang&rft.aulast=Morgan&rft.aufirst=Michael&rft.date=2009-09-01&rft.volume=183&rft.issue=5&rft.spage=3278&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0803428 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-18 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14871-6 [10611305] Cell. 2009 May 15;137(4):721-35 [19427028] Curr Biol. 2000 Jun 1;10(11):640-8 [10837247] J Immunol. 2000 Aug 1;165(3):1337-43 [10903735] Nat Immunol. 2000 Dec;1(6):489-95 [11101870] Nat Immunol. 2001 Apr;2(4):333-7 [11276204] Mol Cell. 2003 Feb;11(2):529-41 [12620239] J Immunol. 2003 Dec 1;171(11):5659-62 [14634070] J Exp Med. 1989 May 1;169(5):1747-56 [2469768] J Immunol Methods. 1991 Jun 3;139(2):271-9 [1710634] Nature. 1993 Aug 26;364(6440):806-9 [7689176] EMBO J. 1995 Mar 15;14(6):1129-35 [7536672] Cell. 1995 May 19;81(4):513-23 [7538908] Science. 1995 Jun 2;268(5215):1347-9 [7539157] Cell. 1995 Jun 16;81(6):935-46 [7540117] EMBO J. 1996 Nov 15;15(22):6189-96 [8947041] Nat Med. 1998 Jan;4(1):31-6 [9427603] Immunity. 1998 Mar;8(3):297-303 [9529147] J Exp Med. 1998 Apr 20;187(8):1205-13 [9547332] J Biol Chem. 2004 Dec 10;279(50):52479-86 [15452120] J Cell Biol. 2005 Mar 28;168(7):1087-98 [15795317] J Immunol. 2005 May 1;174(9):5270-8 [15843523] Mol Cell Biol. 2006 Nov;26(21):8136-48 [16940186] Curr Biol. 2007 Mar 6;17(5):418-24 [17306544] Mol Cell. 2007 Jun 8;26(5):675-87 [17560373] Cell. 2008 May 16;133(4):693-703 [18485876] Mol Cell. 2008 Jun 20;30(6):689-700 [18570872] Nat Immunol. 2008 Sep;9(9):1047-54 [18641653] Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11778-83 [18697935] J Exp Med. 2000 Apr 3;191(7):1209-20 [10748238] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0803428 ER - TY - JOUR T1 - Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. AN - 67595599; 19641140 AB - MCP-1/CCL2 plays a critical role in monocyte recruitment into sites of immune responses and cancer. However, the role of other MCPs remains unclear. In this study, we generated a novel MCP-1-deficient (designated as MCP-1(Delta/Delta)) mouse model by deleting a 2.3-kb DNA fragment from the mouse genome using the Cre/loxP system. MCP-1 was not produced by LPS-activated MCP-1(Delta/Delta) macrophages; however, the production of MCP-3, coded by the immediate downstream gene, was significantly increased. In contrast, macrophages from another mouse line with a neo-gene cassette in intron 2 produced a significantly lower level of MCP-1 and MCP-3. Decreased MCP-3 production was also detected in previously generated MCP-1-deficient mice in which a neo-gene cassette was inserted in exon 2 (designated as MCP-1 knockout (KO)). Altered MCP-1 and/or MCP-3 production was also observed in vivo in each mouse model in response to i.p. injection of thioglycolate or zymosan. The up- and down-regulation of MCP-3 production in MCP-1(Delta/Delta) and MCP-1 KO mice, respectively, provided us with a unique opportunity to evaluate the role for MCP-3. Despite the increased MCP-3 production in MCP-1(Delta/Delta) mice, thioglycolate- or zymosan-induced monocyte/macrophage accumulation was still reduced by approximately 50% compared with wild-type mice, similar to the reduction detected in MCP-1 KO mice. Thus, up-regulated MCP-3 production did not compensate for the loss of MCP-1, and MCP-3 appears to be a less effective mediator of monocyte recruitment than MCP-1. Our results also indicate the presence of other mediators regulating the recruitment of monocytes in these models. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Takahashi, Munehisa AU - Galligan, Carole AU - Tessarollo, Lino AU - Yoshimura, Teizo AD - Laboratory of Molecular Immunoregulation, Cancer, and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 3463 EP - 3471 VL - 183 IS - 5 KW - Ccl2 protein, mouse KW - 0 KW - Chemokine CCL2 KW - Lipopolysaccharides KW - Thioglycolates KW - Zymosan KW - 9010-72-4 KW - Carboxypeptidases A KW - EC 3.4.17.1 KW - Cpa3 protein, mouse KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Down-Regulation -- genetics KW - Lipopolysaccharides -- pharmacology KW - Macrophages, Peritoneal -- metabolism KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Macrophages, Peritoneal -- immunology KW - Down-Regulation -- immunology KW - Up-Regulation -- immunology KW - Mice, Knockout KW - Gene Deletion KW - Chemokine CCL2 -- genetics KW - Peritonitis -- immunology KW - Thioglycolates -- administration & dosage KW - Zymosan -- pharmacology KW - Carboxypeptidases A -- antagonists & inhibitors KW - Cell Movement -- immunology KW - Carboxypeptidases A -- physiology KW - Zymosan -- administration & dosage KW - Chemokine CCL2 -- physiology KW - Chemokine CCL2 -- deficiency KW - Carboxypeptidases A -- biosynthesis KW - Monocytes -- cytology KW - Monocytes -- immunology KW - Monocytes -- metabolism KW - Peritonitis -- chemically induced KW - Thioglycolates -- pharmacology KW - Peritonitis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Monocyte+chemoattractant+protein-1+%28MCP-1%29%2C+not+MCP-3%2C+is+the+primary+chemokine+required+for+monocyte+recruitment+in+mouse+peritonitis+induced+with+thioglycollate+or+zymosan+A.&rft.au=Takahashi%2C+Munehisa%3BGalligan%2C+Carole%3BTessarollo%2C+Lino%3BYoshimura%2C+Teizo&rft.aulast=Takahashi&rft.aufirst=Munehisa&rft.date=2009-09-01&rft.volume=183&rft.issue=5&rft.spage=3463&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0802812 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-18 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0802812 ER - TY - JOUR T1 - Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody. AN - 67592927; 19528217 AB - Three chimpanzee Fabs reactive with lethal factor (LF) of anthrax toxin were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma1 heavy-chain constant regions. In a macrophage toxicity assay, two of the MAbs, LF10E and LF11H, neutralized lethal toxin (LT), a complex of LF and anthrax protective antigen (PA). LF10E has the highest reported affinity for a neutralizing MAb against LF (dissociation constant of 0.69 nM). This antibody also efficiently neutralized LT in vitro, with a 50% effective concentration (EC(50)) of 0.1 nM, and provided 100% protection of rats against toxin challenge with a 0.5 submolar ratio relative to LT. LF11H, on the other hand, had a slightly lower binding affinity to LF (dissociation constant of 7.4 nM) and poor neutralization of LT in vitro (EC(50) of 400 nM) and offered complete protection in vivo only at an equimolar or higher ratio to toxin. Despite this, LF11H, but not LF10E, provided robust synergistic protection when combined with MAb W1, which neutralizes PA. Epitope mapping and binding assays indicated that both LF10E and LF11H recognize domain I of LF (amino acids 1 to 254). Although domain I is responsible for binding to PA, neither MAb prevented LF from binding to activated PA. Although two unique MAbs could protect against anthrax when used alone, even more efficient and broader protection should be gained by combining them with anti-PA MAbs. JF - Infection and immunity AU - Chen, Zhaochun AU - Moayeri, Mahtab AU - Crown, Devorah AU - Emerson, Suzanne AU - Gorshkova, Inna AU - Schuck, Peter AU - Leppla, Stephen H AU - Purcell, Robert H AD - Laboratory of Infectious Diseases1 and Laboratory of Bacterial Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 3902 EP - 3908 VL - 77 IS - 9 KW - Antibodies, Bacterial KW - 0 KW - Antibodies, Monoclonal KW - Antigens, Bacterial KW - Bacterial Toxins KW - Immunoglobulin Fab Fragments KW - anthrax toxin KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Humans KW - Neutralization Tests KW - Molecular Sequence Data KW - Immunoglobulin Fab Fragments -- immunology KW - Amino Acid Sequence KW - Antibody Affinity KW - Pan troglodytes KW - Antibodies, Bacterial -- immunology KW - Antigens, Bacterial -- immunology KW - Bacterial Toxins -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Novel+chimpanzee%2Fhuman+monoclonal+antibodies+that+neutralize+anthrax+lethal+factor%2C+and+evidence+for+possible+synergy+with+anti-protective+antigen+antibody.&rft.au=Chen%2C+Zhaochun%3BMoayeri%2C+Mahtab%3BCrown%2C+Devorah%3BEmerson%2C+Suzanne%3BGorshkova%2C+Inna%3BSchuck%2C+Peter%3BLeppla%2C+Stephen+H%3BPurcell%2C+Robert+H&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2009-09-01&rft.volume=77&rft.issue=9&rft.spage=3902&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=1098-5522&rft_id=info:doi/10.1128%2FIAI.00200-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-03 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - FP59; PDB N1 - SuppNotes - Cited By: J Bacteriol. 1968 Mar;95(3):919-24 [4966834] Infect Immun. 2004 Nov;72(11):6313-7 [15501759] Infect Immun. 1988 Jul;56(7):1807-13 [3384478] Infect Immun. 1990 Jun;58(6):1606-13 [2111283] Hum Antibodies Hybridomas. 1990;1(1):23-6 [2129418] Infect Immun. 1991 Oct;59(10):3472-7 [1910002] Infect Immun. 1992 Feb;60(2):662-8 [1730501] Infect Immun. 1994 Nov;62(11):4955-61 [7927776] Infect Immun. 1995 Apr;63(4):1369-72 [7890396] Immunol Today. 1995 May;16(5):237-42 [7779254] Mol Microbiol. 1995 Feb;15(4):661-6 [7783638] Methods Enzymol. 1996;267:83-109 [8743311] Infect Immun. 1997 Dec;65(12):5171-5 [9393812] Mol Med. 1998 Feb;4(2):87-95 [9508786] Science. 1998 May 1;280(5364):734-7 [9563949] Vaccine. 1998 Jul;16(11-12):1141-8 [9682372] Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11 [9703991] Infect Immun. 2005 Feb;73(2):795-802 [15664918] EMBO J. 2005 Mar 9;24(5):929-41 [15719022] Infect Immun. 2005 Oct;73(10):6547-51 [16177329] Am J Pathol. 2005 Nov;167(5):1309-20 [16251415] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16409-14 [16251269] Vaccine. 2006 Jan 30;24(5):662-70 [16157430] J Infect Dis. 2006 Mar 1;193(5):625-33 [16453257] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1882-7 [16436502] Infect Immun. 2006 Oct;74(10):5840-7 [16988263] Annu Rev Biochem. 2007;76:243-65 [17335404] Infect Immun. 2007 Jul;75(7):3414-24 [17452469] Infect Immun. 2007 Nov;75(11):5425-33 [17646360] Infect Immun. 2007 Nov;75(11):5443-52 [17709410] Hum Antibodies. 2007;16(3-4):99-105 [18334745] FEBS Lett. 1999 Nov 26;462(1-2):199-204 [10580119] Biochemistry. 2000 Jun 6;39(22):6706-13 [10828989] Vaccine. 2001 Apr 30;19(23-24):3241-7 [11312020] Infect Immun. 2001 Jul;69(7):4509-15 [11401993] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Proc Natl Acad Sci U S A. 2002 May 14;99(10):7049-53 [11997439] Nat Biotechnol. 2002 Jun;20(6):597-601 [12042864] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11346-50 [12177434] Biophys J. 2003 Jun;84(6):4062-77 [12770910] Nat Biotechnol. 2003 Nov;21(11):1305-6 [14555959] Vaccine. 2004 Apr 16;22(13-14):1604-8 [15068841] Hum Antibodies. 2003;12(4):129-35 [15156101] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] Proc Natl Acad Sci U S A. 1982 May;79(10):3162-6 [6285339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/IAI.00200-09 ER - TY - JOUR T1 - Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. AN - 67592906; 19483071 AB - Drugs that inhibit dopamine (DA) reuptake through actions at the dopamine transporter (DAT) have been proposed as candidates for development as pharmacotherapies for cocaine abuse. Accordingly, it is important to understand the potential pharmacological interactions of cocaine with other drugs acting at the DAT. Effects of combinations of cocaine with a cocaine analog, 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (WIN 35,428), were compared quantitatively with the combinations of cocaine with the N-butyl,4',4''-diF benztropine analog, 3-(bis(4-fluorophenyl)methoxy)-8-butyl-8-azabicyclo[3.2.1]octane (JHW 007), to determine whether their effects on DA levels in the shell of the nucleus accumbens (NAC) in mice differed. Each of the drugs alone produced dose-related elevations in NAC DA levels. In contrast to the other drugs, JHW 007 was less effective, producing maximal effects that approached 400% of control versus approximately 700% with the other drugs. In addition, the JHW 007 dose-effect curve was not as steep as those for cocaine and WIN 35,428. Combinations of cocaine with its analog, WIN 35,428, were most often greater than those predicted based on dose additivity. In contrast, combinations of cocaine with JHW 007 were most often subadditive. This outcome is consistent with recent studies suggesting that structurally divergent DA uptake inhibitors bind to different domains of the DAT, which can result in different DAT conformations. The conformational changes occurring with JHW 007 binding may result in functional outcomes that alter its abuse liability and its effects in combination with cocaine. JF - The Journal of pharmacology and experimental therapeutics AU - Tanda, Gianluigi AU - Newman, Amy Hauck AU - Ebbs, Aaron L AU - Tronci, Valeria AU - Green, Jennifer L AU - Tallarida, Ronald J AU - Katz, Jonathan L AD - Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 802 EP - 809 VL - 330 IS - 3 KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - N-(n-butyl)-(bis-fluorophenyl)methoxytropane KW - Benztropine KW - 1NHL2J4X8K KW - (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester KW - 50370-56-4 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Microdialysis KW - Animals KW - Dose-Response Relationship, Drug KW - Dopamine Antagonists -- pharmacology KW - Benztropine -- analogs & derivatives KW - Dopamine -- metabolism KW - Mice KW - Benztropine -- pharmacology KW - Drug Synergism KW - Male KW - Nucleus Accumbens -- chemistry KW - Cocaine -- analogs & derivatives KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Combinations+of+cocaine+with+other+dopamine+uptake+inhibitors%3A+assessment+of+additivity.&rft.au=Tanda%2C+Gianluigi%3BNewman%2C+Amy+Hauck%3BEbbs%2C+Aaron+L%3BTronci%2C+Valeria%3BGreen%2C+Jennifer+L%3BTallarida%2C+Ronald+J%3BKatz%2C+Jonathan+L&rft.aulast=Tanda&rft.aufirst=Gianluigi&rft.date=2009-09-01&rft.volume=330&rft.issue=3&rft.spage=802&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.109.154302 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-21 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1999 Jul 29;42(15):2721-36 [10425082] Ann N Y Acad Sci. 1999 Jun 29;877:461-85 [10415665] Pharmacol Biochem Behav. 2005 Mar;80(3):481-91 [15740791] J Pharmacol Exp Ther. 2005 May;313(2):613-20 [15681658] J Neurochem. 2006 Jan;96(2):473-81 [16336224] J Pharmacol Exp Ther. 2006 Jun;317(3):1088-96 [16478825] Pharmacol Ther. 2007 Jan;113(1):197-209 [17079019] J Pharmacol Exp Ther. 2007 Apr;321(1):334-44 [17255465] Pharmacol Biochem Behav. 2007 Oct;87(4):400-4 [17631384] Mol Pharmacol. 2008 Mar;73(3):813-23 [17978168] Nat Neurosci. 2008 Jul;11(7):780-9 [18568020] J Pharmacol Exp Ther. 2009 May;329(2):677-86 [19228996] Psychopharmacology (Berl). 2001 May;155(2):180-6 [11401007] J Pharmacol Exp Ther. 2001 Jul;298(1):1-6 [11408518] J Biol Chem. 2001 Aug 3;276(31):29012-8 [11395483] Synapse. 2002 Jan;43(1):78-85 [11746736] Neuropharmacology. 2003 Mar;44(3):342-53 [12604093] J Pharmacol Exp Ther. 2004 May;309(2):650-60 [14755006] J Pharmacol Exp Ther. 2004 Sep;310(3):981-6 [15175417] J Neurochem. 1986 Jan;46(1):309-12 [3940290] Science. 1987 Sep 4;237(4819):1219-23 [2820058] J Pharmacol Exp Ther. 1989 Oct;251(1):150-5 [2529365] Eur J Pharmacol. 1990 Feb 6;176(2):251-2 [2311671] Trends Neurosci. 1991 Jul;14(7):299-302 [1719677] Pharmacol Biochem Behav. 1991 Oct;40(2):387-97 [1839568] Drug Alcohol Depend. 1993 Mar;32(1):65-71 [8486086] J Pharmacol Exp Ther. 1994 Dec;271(3):1216-22 [7996429] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12304-8 [8618890] Nature. 1997 Apr 24;386(6627):827-30 [9126740] J Med Chem. 1997 Dec 19;40(26):4329-39 [9435902] J Pharmacol Exp Ther. 1999 Apr;289(1):110-22 [10086994] J Neurosci. 2005 Feb 23;25(8):1889-93 [15728828] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.109.154302 ER - TY - JOUR T1 - Changes in hepatic gene expression in response to hepatoprotective levels of zinc. AN - 67589750; 19490425 AB - Zinc (Zn) administration at non-toxic doses protects against the hepatotoxicity produced by many agents, but the underlying mechanisms remain elusive. To examine the basis of Zn-induced generalised hepatoprotective effects. Rats and mice were given Zn at known hepatoprotective levels (100 mumol ZnCl2/kg/day, s.c., for 4 days) and molecular responses were assessed. Zn treatment produced changes in 5% of the genes on custom-designed mouse liver array and Rat Toxicology-II array. Changes in gene expression were further confirmed and extended by real-time reverse transcriptase-polymerase chain reaction. Zn treatment dramatically increased the expression of the metallothionein (Mt), and modestly increased the expression of acute-phase protein genes (ceruloplasmin, Stat3, egr1, Cxc chemokines and heat-shock proteins). For genes encoding for antioxidant enzymes, some were increased (Nrf2 and Nqo1), while others remained unaltered (Cu, Zn SOD and glutathione S-transferases). Expressions of cytokine and pro-inflammatory genes were not affected, while genes related to cell proliferation (cyclin D1) were modestly upregulated. Some metabolic enzyme genes, including cytochrome P450s and UDP-glucuronosyltransferase, were modestly suppressed, perhaps to switch cellular metabolic energy to acute-phase responses. Liver Zn content was increased between 1.6- and 2.1-fold, while hepatic MT protein was increased between 50 and 200-fold. Mice typically showed greater responses than rats. Such gene expression changes, particularly the dramatic induction of MT and Nrf2 antioxidant pathway, occur in the absence of overt liver injury, and are probably important in the hepatoprotective effects of Zn against toxic insults. JF - Liver international : official journal of the International Association for the Study of the Liver AU - Liu, Jie AU - Zhou, Zhan-Xiang AU - Zhang, Wei AU - Bell, Matthew W AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1222 EP - 1229 VL - 29 IS - 8 KW - Chlorides KW - 0 KW - NF-E2-Related Factor 2 KW - Nfe2l2 protein, rat KW - Protective Agents KW - Zinc Compounds KW - zinc chloride KW - 86Q357L16B KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Sprague-Dawley KW - Oligonucleotide Array Sequence Analysis KW - NF-E2-Related Factor 2 -- genetics KW - Injections, Subcutaneous KW - Metallothionein -- genetics KW - Metallothionein -- metabolism KW - Male KW - NF-E2-Related Factor 2 -- metabolism KW - Protective Agents -- administration & dosage KW - Gene Expression -- drug effects KW - Chlorides -- administration & dosage KW - Liver -- drug effects KW - Zinc Compounds -- pharmacology KW - Liver -- metabolism KW - Protective Agents -- pharmacology KW - Zinc Compounds -- administration & dosage KW - Chlorides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67589750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Liver+international+%3A+official+journal+of+the+International+Association+for+the+Study+of+the+Liver&rft.atitle=Changes+in+hepatic+gene+expression+in+response+to+hepatoprotective+levels+of+zinc.&rft.au=Liu%2C+Jie%3BZhou%2C+Zhan-Xiang%3BZhang%2C+Wei%3BBell%2C+Matthew+W%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2009-09-01&rft.volume=29&rft.issue=8&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Liver+international+%3A+official+journal+of+the+International+Association+for+the+Study+of+the+Liver&rft.issn=1478-3231&rft_id=info:doi/10.1111%2Fj.1478-3231.2009.02007.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Toxicol Pathol. 2007 Sep;59(1):29-34 [17582750] Toxicol Pathol. 2007 Jun;35(4):459-73 [17562481] Pharmacol Res. 2008 Feb;57(2):125-31 [18282716] Toxicology. 2008 Apr 3;246(1):24-33 [18083283] Exp Gerontol. 2008 May;43(5):370-7 [18054190] Exp Gerontol. 2008 May;43(5):363-9 [18171607] Biol Pharm Bull. 2000 Mar;23(3):305-8 [10726883] J Nutr. 2000 May;130(5S Suppl):1360S-6S [10801944] J Nutr. 2001 Feb;131(2):215-22 [11160536] Am J Pathol. 2002 Jun;160(6):2267-74 [12057929] J Nutr. 2003 Apr;133(4):1004-10 [12672911] Biol Trace Elem Res. 2003 May;92(2):173-80 [12746576] J Nutr Biochem. 2003 Dec;14(12):691-702 [14690761] Infect Immun. 1977 Mar;15(3):950-7 [323146] Toxicol Appl Pharmacol. 1979 Oct;51(1):107-16 [524364] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Toxicol Appl Pharmacol. 1984 Jul;74(3):299-307 [6740679] Fundam Appl Toxicol. 1985 Apr;5(2):297-304 [3988000] Fundam Appl Toxicol. 1986 Feb;6(2):278-84 [3084325] Histochem J. 1991 Feb;23(2):75-82 [1917562] Biol Trace Elem Res. 1992 Jul;34(1):27-33 [1382519] Fundam Appl Toxicol. 1994 Jul;23(1):32-7 [7958560] Eur J Pharmacol. 1995 Oct 6;293(3):217-24 [8666038] Food Chem Toxicol. 1996 Mar;34(3):301-11 [8621113] Toxicol Appl Pharmacol. 1998 Mar;149(1):24-31 [9512723] Environ Health Perspect. 1998 Feb;106 Suppl 1:297-300 [9539022] J Pharmacol Exp Ther. 1999 Apr;289(1):580-6 [10087053] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Chem Biol Interact. 2004 Nov 20;150(2):199-209 [15535990] J Nutr. 2005 Feb;135(2):199-205 [15671213] Am J Pathol. 2005 Jun;166(6):1681-90 [15920153] Biol Trace Elem Res. 2005 Summer;105(1-3):117-34 [16034158] J Trace Elem Med Biol. 2005;19(1):7-12 [16240665] Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):157-62 [16280147] Toxicol Appl Pharmacol. 2006 Feb 1;210(3):190-9 [15979673] Exp Biol Med (Maywood). 2006 Feb;231(2):138-44 [16446489] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1699-704 [16434472] J Trace Elem Med Biol. 2006;20(1):3-18 [16632171] Hepatology. 2006 Aug;44(2):379-88 [16871587] Exp Biol Med (Maywood). 2006 Oct;231(9):1548-54 [17018879] Shock. 2007 Feb;27(2):157-64 [17224790] J Nutr. 2007 May;137(5):1345-9 [17449604] Exp Biol Med (Maywood). 2007 May;232(5):622-8 [17463158] Dig Dis Sci. 2007 Jul;52(7):1595-612 [17415640] Toxicology. 2008 Jan 20;243(3):249-60 [18078705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1478-3231.2009.02007.x ER - TY - JOUR T1 - A prospective study of cannabis use as a risk factor for non-adherence and treatment dropout in first-episode schizophrenia. AN - 67586395; 19481424 AB - Although several studies have reported on cannabis use and adherence for first episode of psychosis patients, the findings remain unclear as to whether cannabis use is a risk factor for poor adherence in young people with first-episode schizophrenia. This study was designed to follow patients' use of cannabis and adherence in a naturalistic setting during the first 12 months of treatment. It examines whether cannabis use is a risk factor for two distinct types of non-adherence: non-adherence to medication and treatment dropout. Participants were 112 first-episode schizophrenia patients of diverse backgrounds at two community hospitals, enrolled in a study of differential effectiveness of two second-generation antipsychotic medications. Multiple indicators were used to assess cannabis use and adherence to medication. Patients were encouraged to continue in the study even after periods of treatment refusal or change from study to standardized medication. Study hypotheses were tested using Cox proportional hazards models with cannabis use as a time-varying covariate. After 12 months, 23 had dropped out and 37 had at some point been non-adherent to medication. Of 34 participants who used cannabis during treatment, 32 had a prior diagnosis of cannabis abuse/dependence and 30 were male. Independently of age, race, socioeconomic status, gender, site, and medication assignment, cannabis use significantly increased hazard of non-adherence by a factor of 2.4 (p<.001) and hazard of dropout by a factor of 6.4 (p=.034). Results indicate that cannabis use is a risk factor for non-adherence to medication and dropout from treatment. Treatment for first-episode schizophrenia may be more effective if providers address the issue of cannabis use with patients throughout the early years of treatment, especially for those with existing cannabis abuse/dependence. JF - Schizophrenia research AU - Miller, Rachel AU - Ream, Geoffrey AU - McCormack, Joanne AU - Gunduz-Bruce, Handan AU - Sevy, Serge AU - Robinson, Delbert AD - Zucker Hillside Hospital, Glen Oaks, NY 11004, USA. mrachel@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 138 EP - 144 VL - 113 IS - 2-3 KW - Index Medicus KW - Young Adult KW - Psychiatric Status Rating Scales KW - Prospective Studies KW - Risk Factors KW - Humans KW - Adult KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Proportional Hazards Models KW - Patient Compliance -- psychology KW - Patient Dropouts KW - Schizophrenic Psychology KW - Marijuana Abuse -- psychology KW - Marijuana Abuse -- epidemiology KW - Schizophrenia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67586395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=A+prospective+study+of+cannabis+use+as+a+risk+factor+for+non-adherence+and+treatment+dropout+in+first-episode+schizophrenia.&rft.au=Miller%2C+Rachel%3BReam%2C+Geoffrey%3BMcCormack%2C+Joanne%3BGunduz-Bruce%2C+Handan%3BSevy%2C+Serge%3BRobinson%2C+Delbert&rft.aulast=Miller&rft.aufirst=Rachel&rft.date=2009-09-01&rft.volume=113&rft.issue=2-3&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=1573-2509&rft_id=info:doi/10.1016%2Fj.schres.2009.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-29 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Aust N Z J Psychiatry. 2000 Jun;34(3):468-75 [10881971] Arch Gen Psychiatry. 1994 Apr;51(4):273-9 [8161287] Schizophr Res. 2001 Aug 1;51(1):55-61 [11479066] Psychiatr Rehabil J. 2001 Summer;25(1):60-7 [11529454] Soc Psychiatry Psychiatr Epidemiol. 2001 Jul;36(7):332-7 [11606001] Schizophr Bull. 2001;27(4):585-96 [11824485] Psychiatr Serv. 2002 Mar;53(3):337-9 [11875230] Schizophr Res. 2002 Apr 1;54(3):243-51 [11950549] Eur Psychiatry. 2002 May;17(3):148-54 [12052575] Schizophr Res. 2002 Oct 1;57(2-3):209-19 [12223252] Acta Psychiatr Scand. 2002 Oct;106(4):286-90 [12225495] J Clin Psychiatry. 2002 Oct;63(10):892-909 [12416599] Eur Arch Psychiatry Clin Neurosci. 2002 Oct;252(5):226-31 [12451464] Ann Pharmacother. 2003 May;37(5):625-30 [12708934] Acta Psychiatr Scand. 2003 Dec;108(6):439-46 [14616225] Soc Psychiatry Psychiatr Epidemiol. 2004 Jan;39(1):69-72 [15022049] Schizophr Res. 2004 Feb 1;66(2-3):125-35 [15061244] Schizophr Bull. 1990;16(1):57-67 [2333482] Compr Psychiatry. 1998 Jul-Aug;39(4):215-9 [9675506] Br J Psychiatry Suppl. 1998;172(33):45-52 [9764126] Br J Psychiatry Suppl. 1998;172(33):53-9 [9764127] Am J Psychiatry. 1999 Apr;156(4):544-9 [10200732] Drug Alcohol Depend. 2005 Aug 1;79(2):211-23 [16002030] Bull Menninger Clin. 2005 Summer;69(3):220-36 [16178711] Schizophr Res. 2006 Jan 31;81(2-3):145-50 [16298107] Eur Psychiatry. 2006 Jan;21(1):29-33 [16460918] Schizophr Res. 2006 Mar;83(1):53-63 [16529910] Schizophr Res. 2006 Dec;88(1-3):55-62 [16971092] Am J Psychiatry. 2006 Dec;163(12):2096-102 [17151160] Int J Qual Health Care. 2007 Jun;19(3):134-40 [17449480] Am J Public Health. 2007 Oct;97(10):1756-7 [17895405] Drug Alcohol Depend. 2008 Jun 1;95(3):199-208 [18339491] Acta Psychiatr Scand. 2000 Sep;102(3):203-10 [11008856] Schizophr Res. 2002 Jan 1;53(1-2):145-59 [11728846] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.schres.2009.04.018 ER - TY - JOUR T1 - Functional role of Alix in HIV-1 replication. AN - 67583865; 19596386 AB - Retroviral Gag proteins encode small peptide motifs known as late domains that promote the release of virions from infected cells by interacting directly with host cell factors. Three types of retroviral late domains, with core sequences P(T/S)AP, YPX(n)L, and PPPY, have been identified. HIV-1 encodes a primary P(T/S)AP-type late domain and an apparently secondary late domain sequence of the YPX(n)L type. The P(T/S)AP and YPX(n)L motifs interact with the endosomal sorting factors Tsg101 and Alix, respectively. Although biochemical and structural studies support a direct binding between HIV-1 p6 and Alix, the physiological role of Alix in HIV-1 biology remains undefined. To elucidate the function of the p6-Alix interaction in HIV-1 replication, we introduced a series of mutations in the p6 Alix binding site and evaluated the effects on virus particle production and virus replication in a range of cell types, including physiologically relevant primary T cells and macrophages. We also examined the effects of the Alix binding site mutations on virion morphogenesis and single-cycle virus infectivity. We determined that the p6-Alix interaction plays an important role in HIV-1 replication and observed a particularly severe impact of Alix binding site mutations when they were combined with mutational inactivation of the Tsg101 binding site. JF - Virology AU - Fujii, Ken AU - Munshi, Utpal M AU - Ablan, Sherimay D AU - Demirov, Dimiter G AU - Soheilian, Ferri AU - Nagashima, Kunio AU - Stephen, Andrew G AU - Fisher, Robert J AU - Freed, Eric O AD - Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21701-1201, USA. Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 284 EP - 292 VL - 391 IS - 2 KW - Calcium-Binding Proteins KW - 0 KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Endosomal Sorting Complexes Required for Transport KW - PDCD6IP protein, human KW - Transcription Factors KW - Tsg101 protein KW - gag Gene Products, Human Immunodeficiency Virus KW - p6 gag protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Transcription Factors -- metabolism KW - Cells, Cultured KW - Humans KW - Macrophages -- virology KW - Binding Sites -- genetics KW - T-Lymphocytes -- virology KW - Protein Binding KW - Cell Line KW - DNA-Binding Proteins -- metabolism KW - Virus Replication KW - Cell Cycle Proteins -- genetics KW - HIV-1 -- physiology KW - Calcium-Binding Proteins -- genetics KW - Calcium-Binding Proteins -- metabolism KW - gag Gene Products, Human Immunodeficiency Virus -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67583865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Functional+role+of+Alix+in+HIV-1+replication.&rft.au=Fujii%2C+Ken%3BMunshi%2C+Utpal+M%3BAblan%2C+Sherimay+D%3BDemirov%2C+Dimiter+G%3BSoheilian%2C+Ferri%3BNagashima%2C+Kunio%3BStephen%2C+Andrew+G%3BFisher%2C+Robert+J%3BFreed%2C+Eric+O&rft.aulast=Fujii&rft.aufirst=Ken&rft.date=2009-09-01&rft.volume=391&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.06.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-31 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 2009 Apr 25;387(1):200-10 [19269660] PLoS Pathog. 2009 Mar;5(3):e1000339 [19282983] Cell. 2001 Oct 5;107(1):55-65 [11595185] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13925-30 [11717449] Nat Med. 2001 Dec;7(12):1313-9 [11726971] J Virol. 2002 Jan;76(1):105-17 [11739676] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):955-60 [11805336] Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905 [12019106] J Virol. 2003 Jun;77(11):6507-19 [12743307] Cell. 2003 Sep 19;114(6):689-99 [14505569] Cell. 2003 Sep 19;114(6):701-13 [14505570] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12414-9 [14519844] J Virol. 2003 Nov;77(22):12373-7 [14581576] J Biol Chem. 2004 Jan 16;279(3):2046-52 [14585841] Annu Rev Cell Dev Biol. 2004;20:395-425 [15473846] J Virol. 1986 Aug;59(2):284-91 [3016298] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3195-9 [2014240] J Virol. 1994 Apr;68(4):2503-12 [8139032] Virology. 1994 May 1;200(2):623-31 [8178448] J Virol. 1994 Aug;68(8):5311-20 [8035531] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 [8041786] Methods Cell Biol. 1994;43 Pt A:99-112 [7823872] Virology. 1995 Feb 1;206(2):935-44 [7531918] J Virol. 1995 Jun;69(6):3949-54 [7745752] J Virol. 1995 Nov;69(11):6810-8 [7474093] J Virol. 1996 Jan;70(1):159-64 [8523520] Virology. 1998 Nov 10;251(1):1-15 [9813197] J Biol Chem. 1999 Jan 15;274(3):1533-40 [9880530] Virus Res. 2004 Dec;106(2):87-102 [15567490] J Biol Chem. 2005 Dec 9;280(49):40474-80 [16215227] Virology. 2006 Jan 5;344(1):55-63 [16364736] Annu Rev Biophys Biomol Struct. 2006;35:277-98 [16689637] J Cell Sci. 2006 Aug 1;119(Pt 15):3025-32 [16868030] J Biol Chem. 2006 Sep 29;281(39):28699-711 [16882663] Org Lett. 2006 Oct 26;8(22):5165-8 [17048869] J Biol Chem. 2007 Feb 9;282(6):3847-55 [17158451] Nat Struct Mol Biol. 2007 Mar;14(3):194-9 [17277784] Cell. 2007 Mar 9;128(5):841-52 [17350572] Nat Struct Mol Biol. 2007 Apr;14(4):254-6 [17410087] J Virol. 2007 Jun;81(12):6614-22 [17428861] Adv Pharmacol. 2007;55:347-87 [17586320] Science. 2007 Jun 29;316(5833):1908-12 [17556548] EMBO J. 2007 Oct 3;26(19):4215-27 [17853893] Cell Host Microbe. 2007 Mar 15;1(1):5-7 [18005675] Nat Rev Microbiol. 2007 Dec;5(12):912-6 [17982468] Nat Struct Mol Biol. 2008 Jan;15(1):43-9 [18066081] J Virol. 2008 Feb;82(3):1389-98 [18032513] J Virol. 2008 Mar;82(5):2106-19 [18094166] PLoS Pathog. 2008 Mar;4(3):e1000015 [18369466] Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10541-6 [18641129] Methods Mol Biol. 2009;485:163-84 [19020825] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7724-9 [11427703] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.06.016 ER - TY - JOUR T1 - Removal of either N-glycan site from the envelope receptor binding domain of Moloney and Friend but not AKV mouse ecotropic gammaretroviruses alters receptor usage. AN - 67582488; 19584017 AB - Three N-linked glycosylation sites were removed from the envelope glycoproteins of Friend, Moloney, and AKV mouse ecotropic gammaretroviruses: gs1 and gs2, in the receptor binding domain; and gs8, in a region implicated in post-binding cell fusion. Mutants were tested for their ability to infect rodent cells expressing 4 CAT-1 receptor variants. Three mutants (Mo-gs1, Mo-gs2, and Fr-gs1) infect NIH 3T3 and rat XC cells, but are severely restricted in Mus dunni cells and Lec8, a Chinese hamster cell line susceptible to ecotropic virus. This restriction is reproduced in ferret cells expressing M. dunni dCAT-1, but not in cells expressing NIH 3T3 mCAT-1. Virus binding assays, pseudotype assays, and the use of glycosylation inhibitors further suggest that restriction is primarily due to receptor polymorphism and, in M. dunni cells, to glycosylation of cellular proteins. Virus envelope glycan size or type does not affect infectivity. Thus, host range variation due to N-glycan deletion is receptor variant-specific, cell-specific, virus type-specific, and glycan site-specific. JF - Virology AU - Knoper, Ryan C AU - Ferrarone, John AU - Yan, Yuhe AU - Lafont, Bernard A P AU - Kozak, Christine A AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA. Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 232 EP - 239 VL - 391 IS - 2 KW - Viral Envelope Proteins KW - 0 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - Friend murine leukemia virus -- physiology KW - Cricetulus KW - Ferrets KW - Moloney murine leukemia virus -- physiology KW - Mice KW - Glycosylation KW - Cell Line KW - Amino Acid Substitution KW - Cricetinae KW - Leukemia Virus, Murine -- physiology KW - Virus Attachment KW - Viral Envelope Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67582488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Removal+of+either+N-glycan+site+from+the+envelope+receptor+binding+domain+of+Moloney+and+Friend+but+not+AKV+mouse+ecotropic+gammaretroviruses+alters+receptor+usage.&rft.au=Knoper%2C+Ryan+C%3BFerrarone%2C+John%3BYan%2C+Yuhe%3BLafont%2C+Bernard+A+P%3BKozak%2C+Christine+A&rft.aulast=Knoper&rft.aufirst=Ryan&rft.date=2009-09-01&rft.volume=391&rft.issue=2&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.06.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-31 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1988 Mar;62(3):1016-21 [2828650] J Virol. 1987 Oct;61(10):3082-8 [3041030] J Virol. 1992 Jan;66(1):78-84 [1370096] J Virol. 1992 Apr;66(4):2281-7 [1312632] J Virol. 1992 Jul;66(7):4258-64 [1318404] J Virol. 1993 Mar;67(3):1310-4 [8382297] J Virol. 1993 Apr;67(4):2091-6 [8445722] J Virol. 1993 Jul;67(7):4056-61 [8510216] J Biol Chem. 1993 Aug 5;268(22):16316-20 [8393858] J Virol. 1993 Sep;67(9):5346-52 [8394452] J Virol. 1994 Feb;68(2):626-31 [8289366] Virology. 1994 Jul;202(1):496-9 [8009864] J Virol. 1996 Oct;70(10):6884-91 [8794331] J Virol. 1996 Dec;70(12):8534-9 [8970977] Virology. 1997 Mar 3;229(1):49-56 [9123877] J Virol. 1997 Sep;71(9):7012-9 [9261431] Science. 1997 Sep 12;277(5332):1662-6 [9287219] J Virol. 1999 May;73(5):3758-63 [10196270] J Virol. 1999 Jul;73(7):5671-80 [10364317] J Virol. 1999 Nov;73(11):9362-8 [10516044] J Virol. 2005 Jun;79(12):7868-76 [15919941] J Virol. 2006 Mar;80(5):2539-47 [16474160] J Virol. 2007 Oct;81(19):10550-7 [17634227] Retrovirology. 2008;5:2 [18186934] Cell Mol Life Sci. 2008 Nov;65(21):3383-98 [18818872] J Virol. 2001 Jul;75(13):5998-6006 [11390601] Virology. 2002 Nov 25;303(2):338-44 [12490395] Curr Top Microbiol Immunol. 2003;281:29-106 [12932075] Virology. 1970 Dec;42(4):1136-9 [4099080] Genetics. 1972 Oct;72(2):239-52 [4345996] J Biol Chem. 1975 May 10;250(9):3303-9 [1168193] Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92 [191826] Biochem Biophys Res Commun. 1979 Feb 28;86(4):1206-13 [435320] J Virol. 1980 Jan;33(1):475-86 [6245244] Proc Natl Acad Sci U S A. 1980 Nov;77(11):6420-4 [6935656] J Virol. 1984 Nov;52(2):695-8 [6092693] J Virol. 1991 Oct;65(10):5323-32 [1895386] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.06.015 ER - TY - JOUR T1 - Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells. AN - 67549516; 19524486 AB - Human herpesvirus-6 (HHV-6) has been associated with a wide spectrum of diseases. (r)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) is an acyclic guanosine analogue that is structurally similar to acyclovir and is in clinical development for treatment of herpesvirus infections. H2G has been found to have activity against HSV type 1, HSV type 2, and HHV-6 in lymphoblast cell lines. A new anti-viral duplex drug, 3'-azido-3'-deoxythymidylyl-(5'-->2-O)-3-O-octadecyl-sn-glycerol (AZT-lipid-PFA), linking zidovudine (AZT) and foscarnet (PFA) via a lipophilic octadecylglycerol residue (lipid) also exhibits anti-viral activities against HIV, HSV type 1 and HCMV. To assess the efficacy of H2G and AZT-lipid-PFA conjugate against HHV-6. Drug-associated toxicity and proliferative response were evaluated. We conducted in vitro experiments to determine the efficacy of H2G and an AZT-lipid-PFA conjugate in interfering with expression HHV-6 viral transcript in primary human peripheral blood mononuclear cells (PBMC). Both H2G and AZT-lipid-PFA were effective at inhibiting expression of HHV-6 gene transcript at comparable concentrations. Additionally, while AZT-lipid-PFA treatment was toxic to cells at concentrations above 5microM, H2G treatment was associated with minimal cytotoxicity. These data suggest the potential application of these anti-viral compounds in controlling HHV-6 infection. JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology AU - Yao, Karen AU - Hoest, Christel AU - Rashti, Farzin AU - Schott, Timm C AU - Jacobson, Steven AD - Viral Immunology Section, Neuroimmunology Branch, NINDS, NIH, Bethesda, MD 20892, United States. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 10 EP - 14 VL - 46 IS - 1 KW - Antiviral Agents KW - 0 KW - 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine KW - 105868-85-7 KW - Zidovudine KW - 4B9XT59T7S KW - Guanine KW - 5Z93L87A1R KW - Index Medicus KW - Transcription, Genetic -- drug effects KW - Leukocytes, Mononuclear -- virology KW - Cell Survival -- drug effects KW - Virus Replication -- drug effects KW - Cells, Cultured KW - Humans KW - Hepatocytes -- virology KW - Microbial Sensitivity Tests -- methods KW - Cell Line KW - Zidovudine -- analogs & derivatives KW - Guanine -- toxicity KW - Zidovudine -- toxicity KW - Herpesvirus 6, Human -- drug effects KW - Antiviral Agents -- pharmacology KW - Zidovudine -- pharmacology KW - Guanine -- analogs & derivatives KW - Antiviral Agents -- toxicity KW - Guanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67549516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+virology+%3A+the+official+publication+of+the+Pan+American+Society+for+Clinical+Virology&rft.atitle=Effect+of+%28r%29-9-%5B4-hydroxy-2-%28hydroxymethyl%29butyl%5Dguanine+%28H2G%29+and+AZT-lipid-PFA+on+human+herpesvirus-6B+infected+cells.&rft.au=Yao%2C+Karen%3BHoest%2C+Christel%3BRashti%2C+Farzin%3BSchott%2C+Timm+C%3BJacobson%2C+Steven&rft.aulast=Yao&rft.aufirst=Karen&rft.date=2009-09-01&rft.volume=46&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+virology+%3A+the+official+publication+of+the+Pan+American+Society+for+Clinical+Virology&rft.issn=1873-5967&rft_id=info:doi/10.1016%2Fj.jcv.2009.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-30 N1 - Date created - 2009-08-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jcv.2009.05.014 ER - TY - JOUR T1 - Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). AN - 67527223; 19394271 AB - Concerns about reproductive and developmental health risks of exposure to organophosphate (OP) pesticides, phthalates, and bisphenol A (BPA) among the general population are increasing. Six dialkyl phosphate (DAP) metabolites, 3,5,6-trichloro-2-pyridinol (TCPy), BPA, and fourteen phthalate metabolites were measured in 10 pooled urine samples representing 110 pregnant women who participated in the Norwegian Mother and Child Birth Cohort (MoBa) study in 2004. Daily intakes were estimated from urinary data and compared with reference doses (RfDs) and daily tolerable intakes (TDIs). The MoBa women had a higher mean BPA concentration (4.50 microg/L) than the pregnant women in the Generation R Study (Generation R) in the Netherlands and the National Health and Nutrition Examination Survey (NHANES) in the United States. The mean concentration of total DAP metabolites (24.20 microg/L) in MoBa women was higher than that in NHANES women but lower than that in Generation R women. The diethyl phthalate metabolite mono-ethyl phthalate (MEP) was the dominant phthalate metabolite in all three studies, with the mean concentrations of greater than 300 microg/L. The MoBa and Generation R women had higher mean concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl phthalate (MiBP) than the NHANES women. The estimated average daily intakes of BPA, chlorpyrifos/chlorpyrifos-methyl and phthalates in MoBa (and the other two studies) were below the RfDs and TDIs. The higher levels of metabolites in the MoBa participants may have been from intake via pesticide residues in food (organophosphates), consumption of canned food, especially fish/seafood (BPA), and use of personal care products (selected phthalates). JF - International journal of hygiene and environmental health AU - Ye, Xibiao AU - Pierik, Frank H AU - Angerer, Jürgen AU - Meltzer, Helle Margrete AU - Jaddoe, Vincent W V AU - Tiemeier, Henning AU - Hoppin, Jane A AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 481 EP - 491 VL - 212 IS - 5 KW - Benzhydryl Compounds KW - 0 KW - Organophosphates KW - Pesticides KW - Phenols KW - Phthalic Acids KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Norway KW - Adolescent KW - Female KW - Pregnancy KW - Pesticides -- urine KW - Environmental Exposure -- analysis KW - Organophosphates -- urine KW - Phenols -- urine KW - Phthalic Acids -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67527223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Levels+of+metabolites+of+organophosphate+pesticides%2C+phthalates%2C+and+bisphenol+A+in+pooled+urine+specimens+from+pregnant+women+participating+in+the+Norwegian+Mother+and+Child+Cohort+Study+%28MoBa%29.&rft.au=Ye%2C+Xibiao%3BPierik%2C+Frank+H%3BAngerer%2C+J%C3%BCrgen%3BMeltzer%2C+Helle+Margrete%3BJaddoe%2C+Vincent+W+V%3BTiemeier%2C+Henning%3BHoppin%2C+Jane+A%3BLongnecker%2C+Matthew+P&rft.aulast=Ye&rft.aufirst=Xibiao&rft.date=2009-09-01&rft.volume=212&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=1618-131X&rft_id=info:doi/10.1016%2Fj.ijheh.2009.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Paediatr Perinat Epidemiol. 2008 Sep;22(5):486-96 [18782255] JAMA. 2008 Sep 17;300(11):1303-10 [18799442] Environ Res. 2008 Oct;108(2):260-7 [18774129] J Expo Sci Environ Epidemiol. 2008 Nov;18(6):608-15 [18414515] Eur J Pharm Biopharm. 2008 Nov;70(3):921-8 [18620051] Eur J Clin Nutr. 2009 Mar;63(3):347-54 [18059417] Regul Toxicol Pharmacol. 1999 Oct;30(2 Pt 2):S109-13 [10597623] Environ Health Perspect. 2000 Jun;108 Suppl 3:451-5 [10852844] Biometrics. 1999 Sep;55(3):718-26 [11314998] Int J Hyg Environ Health. 2001 Nov;204(2-3):175-80 [11759161] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):5-29 [12376114] Reprod Toxicol. 2002 Sep-Oct;16(5):721-34 [12406498] Environ Health Perspect. 2003 Jan;111(1):101-4 [12515686] Stat Med. 2003 Aug 15;22(15):2515-27 [12872306] Environ Res. 2003 Oct;93(2):177-85 [12963402] Environ Health Perspect. 2004 Mar;112(3):331-8 [14998749] Kidney Int. 1989 Jul;36(1):108-13 [2811052] Environ Health Perspect. 1999 Jun;107 Suppl 3:431-7 [10346991] Environ Health Perspect. 2005 Apr;113(4):391-5 [15811827] Environ Health Perspect. 2005 Apr;113(4):494-8 [15811842] Food Addit Contam. 2005 Jan;22(1):65-72 [15895613] J Expo Anal Environ Epidemiol. 2005 Jul;15(4):297-309 [15367928] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Clin Chim Acta. 2005 Nov;361(1-2):20-9 [16004980] Occup Environ Med. 2005 Nov;62(11):806-18 [16234408] Environ Res. 2005 Nov;99(3):314-26 [16307973] Environ Sci. 2006;13(1):15-29 [16685249] Environ Health Perspect. 2006 Jun;114(6):805-9 [16759976] Eur J Epidemiol. 2006;21(6):475-84 [16826450] Eur J Epidemiol. 2006;21(8):619-25 [17031521] Int J Epidemiol. 2006 Oct;35(5):1146-50 [16926217] Int J Hyg Environ Health. 2007 Jan;210(1):35-42 [17185035] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):334-41 [17301268] Environ Health Perspect. 2007 May;115(5):792-8 [17520070] Am J Epidemiol. 2007 Jun 15;165(12):1397-404 [17406008] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):378-87 [17006438] Chemosphere. 2007 Sep;69(3):371-80 [17618673] Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395 [18613034] Crit Rev Toxicol. 2008;38 Suppl 2:1-125 [18726789] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijheh.2009.03.004 ER - TY - JOUR T1 - Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. AN - 67511664; 19561539 AB - T cells can be engineered to express the genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. We constructed and compared 2 CARs that contained a single chain variable region moiety that recognized CD19. One CAR contained the signaling moiety of the 4-1BB molecule and the other did not. We selected the CAR that did not contain the 4-1BB moiety for further preclinical development. We demonstrated that gammaretroviruses encoding this receptor could transduce human T cells. Anti-CD19-CAR-transduced CD8+ and CD4+ T cells produced interferon-gamma and interleukin-2 specifically in response to CD19+ target cells. The transduced T cells specifically killed primary chronic lymphocytic leukemia (CLL) cells. We transduced T cells from CLL patients that had been previously treated with chemotherapy. We induced these T cells to proliferate sufficiently to provide enough cells for clinical adoptive T cell transfer with a protocol consisting of an initial stimulation with an anti-CD3 monoclonal antibody (OKT3) before transduction followed by a second OKT3 stimulation 7 days after transduction. This protocol was successfully adapted for use in CLL patients with high peripheral blood leukemia cell counts by depleting CD19+ cells before the initial OKT3 stimulation. In preparation for a clinical trial that will enroll patients with advanced B cell malignancies, we generated a producer cell clone that produces retroviruses encoding the anti-CD19 CAR, and we produced sufficient retroviral supernatant for the proposed clinical trial under good manufacturing practice conditions. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Kochenderfer, James N AU - Feldman, Steven A AU - Zhao, Yangbing AU - Xu, Hui AU - Black, Mary A AU - Morgan, Richard A AU - Wilson, Wyndham H AU - Rosenberg, Steven A AD - Surgery Branch of the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. kochendj@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 689 EP - 702 VL - 32 IS - 7 KW - Antigens, CD19 KW - 0 KW - Interleukin-2 KW - Muromonab-CD3 KW - Receptors, Antigen KW - Receptors, Nerve Growth Factor KW - Recombinant Fusion Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - CD4-Positive T-Lymphocytes -- cytology KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - Transduction, Genetic KW - CD4-Positive T-Lymphocytes -- immunology KW - Receptors, Nerve Growth Factor -- metabolism KW - Recombinant Fusion Proteins -- metabolism KW - Gammaretrovirus -- genetics KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Interferon-gamma -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Enzyme-Linked Immunosorbent Assay KW - Leukemia, Lymphocytic, Chronic, B-Cell -- therapy KW - Interleukin-2 -- metabolism KW - Receptors, Nerve Growth Factor -- genetics KW - Recombinant Fusion Proteins -- immunology KW - Cell Line, Tumor KW - K562 Cells KW - Immunotherapy -- methods KW - CD8-Positive T-Lymphocytes -- cytology KW - CD4-Positive T-Lymphocytes -- metabolism KW - Muromonab-CD3 -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Cytotoxicity Tests, Immunologic KW - Leukemia, Lymphocytic, Chronic, B-Cell -- pathology KW - Genetic Vectors -- genetics KW - Drug Evaluation, Preclinical KW - T-Lymphocytes -- metabolism KW - T-Lymphocytes -- cytology KW - Antigens, CD19 -- immunology KW - Receptors, Antigen -- genetics KW - Antigens, CD19 -- genetics KW - Receptors, Antigen -- immunology KW - Cytotoxicity, Immunologic -- immunology KW - Antigens, CD19 -- metabolism KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67511664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Construction+and+preclinical+evaluation+of+an+anti-CD19+chimeric+antigen+receptor.&rft.au=Kochenderfer%2C+James+N%3BFeldman%2C+Steven+A%3BZhao%2C+Yangbing%3BXu%2C+Hui%3BBlack%2C+Mary+A%3BMorgan%2C+Richard+A%3BWilson%2C+Wyndham+H%3BRosenberg%2C+Steven+A&rft.aulast=Kochenderfer&rft.aufirst=James&rft.date=2009-09-01&rft.volume=32&rft.issue=7&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=1537-4513&rft_id=info:doi/10.1097%2FCJI.0b013e3181ac6138 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2007 Jun 1;109(11):2182-9 [17429839] Hum Gene Ther. 2007 Aug;18(8):712-25 [17685852] Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5426-35 [17855649] Blood. 2007 Oct 15;110(8):2811-8 [17638850] Leuk Lymphoma. 2008 Mar;49(3):398-409 [18297516] Nature. 1999 Oct 14;401(6754):708-12 [10537110] J Immunol. 2001 Jan 1;166(1):182-7 [11123291] Nat Immunol. 2001 Oct;2(10):957-61 [11577349] Nat Biotechnol. 2002 Jan;20(1):70-5 [11753365] J Immunol. 2002 May 15;168(10):4897-906 [11994439] Blood. 2002 Nov 1;100(9):3108-14 [12384406] Blood. 2002 Nov 1;100(9):3155-63 [12384413] Science. 2002 Oct 25;298(5594):850-4 [12242449] Nat Rev Cancer. 2003 Jan;3(1):35-45 [12509765] Blood. 2003 Feb 15;101(4):1637-44 [12393484] Nat Med. 2003 Mar;9(3):279-86 [12579196] Bone Marrow Transplant. 2003 Dec;32(12):1159-63 [14647270] J Clin Oncol. 2003 Dec 1;21(23):4407-12 [14645431] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1291-6 [14745033] J Immunol Methods. 2004 Feb 1;285(1):25-40 [14871532] Leukemia. 2004 Apr;18(4):676-84 [14961035] J Immunol. 1983 Jul;131(1):244-50 [6408173] Proc Natl Acad Sci U S A. 1983 Oct;80(20):6351-5 [6312453] Blood. 1988 Jan;71(1):13-29 [3257143] Hum Gene Ther. 1997 Jul 1;8(10):1189-94 [9215736] Mol Immunol. 1997 Nov-Dec;34(16-17):1157-65 [9566763] J Clin Oncol. 1998 Aug;16(8):2825-33 [9704735] J Immunol. 1998 Sep 15;161(6):2791-7 [9743337] J Immunol. 1999 May 1;162(9):5037-40 [10227968] Blood. 2004 Dec 1;104(12):3535-42 [15304387] Blood. 2005 Jan 1;105(1):241-50 [15345595] Blood. 1993 Jul 15;82(2):417-29 [7687158] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8033-7 [8396259] Cancer Res. 1995 Aug 1;55(15):3369-73 [7614473] Leuk Lymphoma. 1995 Aug;18(5-6):385-97 [8528044] J Immunol. 1996 Jul 1;157(1):29-38 [8683128] Hum Gene Ther. 1996 May 20;7(8):913-9 [8727505] J Exp Med. 1997 Jul 7;186(1):47-55 [9206996] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] Br J Haematol. 2005 May;129(3):322-32 [15842655] Hum Gene Ther. 2005 Apr;16(4):457-72 [15871677] Bone Marrow Transplant. 2005 Sep;36(5):437-41 [15980879] J Exp Med. 2005 Oct 3;202(7):907-12 [16203864] J Immunother. 2006 Jan-Feb;29(1):21-31 [16365597] Semin Oncol. 2006 Apr;33(2):202-9 [16616067] J Clin Oncol. 2006 May 1;24(13):e20-2 [16648493] Blood Rev. 2006 Sep;20(5):235-44 [16513231] Science. 2006 Oct 6;314(5796):126-9 [16946036] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15 [17062687] Cancer Res. 2006 Nov 15;66(22):10995-1004 [17108138] Leukemia. 2007 Jan;21(1):12-7 [17109028] J Clin Immunol. 2007 May;27(3):308-16 [17510807] Gene. 1989 Apr 15;77(1):51-9 [2744487] Cell. 1989 Sep 8;58(5):911-21 [2528411] Proc Natl Acad Sci U S A. 1989 Dec;86(24):10024-8 [2513569] J Immunol Methods. 1990 Apr 17;128(2):189-201 [1691237] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):720-4 [8421711] J Exp Med. 1993 Mar 1;177(3):845-50 [7679711] J Exp Med. 1993 Jul 1;178(1):361-6 [8315392] Eur J Haematol. 1993 May;50(5):292-6 [7686506] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CJI.0b013e3181ac6138 ER - TY - JOUR T1 - A comprehensive review of the literature on exposure to metalworking fluids. AN - 67405660; 19544177 AB - An extensive literature review was conducted of studies with exposure measurements to metalworking fluids (MWFs). A database of 155 arithmetic means based on 9379 aerosol measurements from published studies was compiled. Weighted arithmetic means (WAMs) and their variance calculated across studies were summarized based on decade (prior to 1970s through 2000s), industry (auto, auto parts, small job shops, and others), operation (grinding and machining), and fluid type (straight, soluble, synthetic, and semisynthetic). Total mass and total extractable mass measurements that were simultaneously collected were compared. Average concentrations by size fractions and mass median aerodynamic diameters (MMADs) were also analyzed. Analysis of the WAMs indicated a reduction in exposure levels over time regardless of industry or type of operation or fluid, with mean levels prior to the 1970s of 5.4 mg/m(3), which dropped to 2.5 mg/m(3) in the 1970s, to 1.2 mg/m(3) in the 1980s, and to 0.5 mg/m(3) in the 1990s. No further reduction was seen in the 2000s. A comparison by industry, operation, and fluid type found no consistent patterns in the measurement results. The percent extractable mass in the total aerosol samples varied by fluid type, with an average 84% in straight fluids, 58% in synthetic fluids, 56% in soluble fluids, and 42% in the semisynthetic fluids. Exposure means from the thoracic fraction (0.3-0.5 mg/m(3)) were slightly less than those for total aerosol for both the 1990s and 2000s, the only decades for which thoracic data were available. Respirable means did not change from the 1980s to the 2000s (generally about 0.2-0.3 mg/m(3)). The MMADs of the MWF aerosols averaged 4-6 microm. These measurement data indicate a clear reduction of exposure levels over time. They will be used for the retrospective assessment of exposure levels to MWFs in a population-based, case-control study of bladder cancer. JF - Journal of occupational and environmental hygiene AU - Park, Donguk AU - Stewart, Patricia A AU - Coble, Joseph B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. dongukp@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 530 EP - 541 VL - 6 IS - 9 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Industrial Waste KW - Lubricants KW - Index Medicus KW - Aerosols -- analysis KW - Skin -- chemistry KW - Lubricants -- analysis KW - History, 20th Century KW - Inhalation Exposure -- analysis KW - Air Pollutants, Occupational -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Humans KW - Industrial Waste -- analysis KW - Information Storage and Retrieval KW - Occupational Exposure -- history KW - Occupational Exposure -- classification KW - Metallurgy -- statistics & numerical data KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67405660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=A+comprehensive+review+of+the+literature+on+exposure+to+metalworking+fluids.&rft.au=Park%2C+Donguk%3BStewart%2C+Patricia+A%3BCoble%2C+Joseph+B&rft.aulast=Park&rft.aufirst=Donguk&rft.date=2009-09-01&rft.volume=6&rft.issue=9&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620903065984 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-10 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620903065984 ER - TY - JOUR T1 - Research Dissemination and Diffusion AN - 61416231; 200907034 AB - In moving health and social service programs from planning into action, it is essential to understand the extent to which the knowledge gained from research should influence the actions taken by organizations and agencies that provide services (e.g., government, nongovernment organizations [NGOs]). The complexity of the challenges in translating lessons learned from science into different service settings, as well as into public policy, requires a multifaceted approach to accelerate the integration of research with practice. In this paper, the relationship between science and service is examined within the contexts of the scientific, health practice, and policy communities largely from a public sector perspective within the United States. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Research on Social Work Practice AU - Kerner, Jon F AU - Hall, Kara L AD - National Cancer Institute kernerj@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 519 EP - 530 PB - Sage Publications, Thousand Oaks CA VL - 19 IS - 5 SN - 1049-7315, 1049-7315 KW - translation diffusion dissemination research practice policy KW - Social Policy KW - Government Agencies KW - Information Dissemination KW - Social Services KW - Health KW - Social Integration KW - Social Programs KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61416231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+on+Social+Work+Practice&rft.atitle=Research+Dissemination+and+Diffusion&rft.au=Kerner%2C+Jon+F%3BHall%2C+Kara+L&rft.aulast=Kerner&rft.aufirst=Jon&rft.date=2009-09-01&rft.volume=19&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Research+on+Social+Work+Practice&rft.issn=10497315&rft_id=info:doi/10.1177%2F1049731509335585 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 40 N1 - Last updated - 2016-09-28 N1 - CODEN - RSWPEW N1 - SubjectsTermNotLitGenreText - Information Dissemination; Social Services; Social Policy; Government Agencies; Health; Social Integration; Social Programs DO - http://dx.doi.org/10.1177/1049731509335585 ER - TY - JOUR T1 - Self-Concept in Adult Children of Schizophrenic Parents: an Exploratory Study AN - 57309465; 200927488 AB - Background: Much of the work on children of schizophrenic parents has primarily focused on the risk of developing various kinds of psychiatric disorders, behavioural problems and cognitive vulnerability factors. There has been inadequate attention given to children without a clinical diagnosis and particularly the adult offspring of schizophrenic parents. It would be worthwhile to study the wellness or otherwise of these children, especially in terms of the self-concept of these individuals. Aim: To study the impact of parental mental illness on the self-concept of adult children. Method: Thirty subjects who had one parent diagnosed as suffering from schizophrenia formed the study group, and 30 subjects, matched on age and gender with the study group, formed the control group. Subjects were assessed using a socio-demographic and clinical data sheet and a self-concept scale. Results: The results showed that the study group had significantly poorer self-concept compared to the control group. The current clinical status of the parents had an impact on the family self-esteem of the children. Subjects who were above 10 years of age at the onset of the parental mental illness had a poorer self-concept, as compared to those who were below 10 years at the onset of illness in their parents. Conclusions: The results provide evidence for poor self-concept in adult children of schizophrenic parents compared to children of normal parents. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - International Journal of Social Psychiatry AU - Manjula, M AU - Raguram, A AD - Department of Mental Health and Social Psychology, National Institute of Mental Health and Neurosciences, Bangalore-29, Karnataka State, India manjula_m_99@yahoo.com Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 471 EP - 479 PB - Sage Publications, London UK VL - 55 IS - 5 SN - 0020-7640, 0020-7640 KW - adult children schizophrenic parents self-concept KW - Schizophrenia KW - Mentally ill parents KW - Selfconcept KW - Adult children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57309465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Social+Psychiatry&rft.atitle=Self-Concept+in+Adult+Children+of+Schizophrenic+Parents%3A+an+Exploratory+Study&rft.au=Manjula%2C+M%3BRaguram%2C+A&rft.aulast=Manjula&rft.aufirst=M&rft.date=2009-09-01&rft.volume=55&rft.issue=5&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/10.1177%2F0020764008094732 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - IJSPAG N1 - SubjectsTermNotLitGenreText - Selfconcept; Schizophrenia; Adult children; Mentally ill parents DO - http://dx.doi.org/10.1177/0020764008094732 ER - TY - JOUR T1 - Human Health and the Environment: In Harmony or in Conflict? AN - 57306604; 200926125 AB - Health policy frameworks usually construe environmental protection and human health as harmonious values. Policies that protect the environment, such as pollution control and pesticide regulation, also benefit human health. In recent years, however, it has become apparent that promoting human health sometimes undermines environmental protection. Some actions, policies, or technologies that reduce human morbidity, mortality, and disease can have detrimental effects on the environment. Since human health and environmental protection are sometimes at odds, political leaders, citizens, and government officials need a way to mediate and resolve conflicts between these values. Unfortunately, few approaches to applied bioethics have the conceptual tools to do accomplish this task. Theories of health care ethics have little to say about the environment, and theories of environmental ethics don't say much about human health. In this essay, I defend an approach to ethical decision-making that gives policy-makers some tools for balancing promotion of human health and protection of the environment. Adapted from the source document. JF - Health Care Analysis AU - Resnik, David B AD - National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Mail Drop NH 06, Box 12233, Research Triangle Park, NC 27709, USA resnikd@niehs.nih.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 261 EP - 276 PB - Springer Science+Business Media, Inc, New York, NY VL - 17 IS - 3 SN - 1065-3058, 1065-3058 KW - Ethical dilemmas KW - Ethics KW - Health KW - Environmental protection KW - Health promotion KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57306604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+Analysis&rft.atitle=Human+Health+and+the+Environment%3A+In+Harmony+or+in+Conflict%3F&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2009-09-01&rft.volume=17&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Health+Care+Analysis&rft.issn=10653058&rft_id=info:doi/10.1007%2Fs10728-008-0104-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - HCAVEO N1 - SubjectsTermNotLitGenreText - Health; Environmental protection; Ethics; Morbidity-Mortality; Health promotion; Ethical dilemmas DO - http://dx.doi.org/10.1007/s10728-008-0104-x ER - TY - JOUR T1 - Cancer in the elderly: The caregivers' perception of senior patients' informational needs AN - 57303828; 200918713 AB - The aim of our study was to explore the caregivers' perception of the informational needs of Italian elderly cancer patients at the time of diagnosis. We asked the senior cancer patients naive for treatments and their caregivers, admitted to our National Cancer Centre, to take a written self-administered questionnaire exploring the patient's information needs and his/her information-seeking behavior. The questionnaire was completed by 112 elderly cancer patients (median age 72 years) and their caregivers (median age 54 years). Patients were mostly affected by genital-urinary (27%) or breast/gynecological (25%) cancer. Caregivers were usually females (71%), daughters/sons (45%) and/or partners (41%). One-third of the senior patients showed a desire to receive extensive information regarding diagnosis and gravity, while 44.6% wanted to know about recovery. Caregivers showed improper recognition of the real needs for information of the their own patients (^D*k tests showed unsatisfactory or poor agreement). Caregivers cannot be considered the preferred spokespersons of the oncologist when the patient is elderly or his/her needs for information again remain unmet. Interventions, both to help senior patients express their needs and to improve the patient-to-doctor-to-caregiver communication about cancer diseases, are necessary. [Copyright Elsevier B.V.] JF - Archives of Gerontology and Geriatrics AU - Giacalone, Annalisa AU - Talamini, Renato AU - Fratino, Lucia AU - Simonelli, Cecilia AU - Bearz, Alessandra AU - Spina, Michele AU - Tirelli, Umberto AD - Division of Medical Oncology A, National Cancer Institute, Centro di Riferimento Oncologico, Via Franco Gallini 2, 33081 Aviano (PN), Italy agiacalone@cro.it Y1 - 2009/09// PY - 2009 DA - September 2009 SP - e121 EP - e125 PB - Elsevier Ltd, The Netherlands VL - 49 IS - 2 SN - 0167-4943, 0167-4943 KW - Cancer in elderly Caregiver Communication about cancer Informational needs of elderly KW - Elderly people KW - Diagnosis KW - Information needs KW - Sick elderly people KW - Cancer KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Gerontology+and+Geriatrics&rft.atitle=Cancer+in+the+elderly%3A+The+caregivers%27+perception+of+senior+patients%27+informational+needs&rft.au=Giacalone%2C+Annalisa%3BTalamini%2C+Renato%3BFratino%2C+Lucia%3BSimonelli%2C+Cecilia%3BBearz%2C+Alessandra%3BSpina%2C+Michele%3BTirelli%2C+Umberto&rft.aulast=Giacalone&rft.aufirst=Annalisa&rft.date=2009-09-01&rft.volume=49&rft.issue=2&rft.spage=e121&rft.isbn=&rft.btitle=&rft.title=Archives+of+Gerontology+and+Geriatrics&rft.issn=01674943&rft_id=info:doi/10.1016%2Fj.archger.2008.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Cancer; Information needs; Diagnosis; Elderly people; Sick elderly people DO - http://dx.doi.org/10.1016/j.archger.2008.10.004 ER - TY - JOUR T1 - Brief report: Speed of response to threshold and suprathreshold bilateral ECT in depression, mania and schizophrenia AN - 57287050; 200920761 AB - Background Bilateral electroconvulsive therapy (BLECT) is useful in affective disorders and schizophrenia. Studies on electrical dose during BLECT are sparse. The Royal College of Psychiatrists recommends the use of electrical dose at 50 -100% above seizure threshold. We studied the impact of change of BLECT practice from using threshold-level to 1.5 times threshold-level electrical dose in patients with depression, mania and schizophrenia. Method Data of 100 consecutive inpatients who received BLECT at threshold-level was compared with that of 101 who received BLECT at 1.5 times threshold-level. Patients in the two groups were comparable in sociodemographic and clinical details. In all patients ECT was stopped after patients had shown clinical improvement. Number of ECTs required to achieve improvement and the number of inpatient days after the start of ECT formed the outcome measures. Results Overall, there was no significant difference between the groups in the outcome variables. However, when diagnoses were considered separately, patients with mania who received threshold-level needed about 2 more ECT sessions (t = 2.6; p = 0.01) and stayed for about 10 more days as inpatients (t = 2.4; p = 0.03) than those who received 1.5 times threshold-level BLECT. Limitations The study is chart-based, with its inherent limitations. Standard outcome measures were not used. Cognitive adverse effects were not studied. Conclusions Patients with schizophrenia and depression treated with BLECT at 1.5 times threshold-level electrical stimulus require similar number of ECT sessions as with threshold-level. However, patients with mania show clinical improvement with significantly fewer ECT sessions if treated at suprathreshold stimulus. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Thirthalli, Jagadisha AU - Kumar, Channaveerachari Naveen AU - Bangalore, Ravi P AU - Gangadhar, Bangalore N AD - Department of Psychiatry National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore-560029, India Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 104 EP - 107 PB - Elsevier Ltd, The Netherlands VL - 117 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Electroconvulsive therapy Threshold Depression Mania Schizophrenia KW - Schizophrenia KW - Mania KW - Electroconvulsive therapy KW - Depression KW - Hospitalization KW - Thresholds KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Brief+report%3A+Speed+of+response+to+threshold+and+suprathreshold+bilateral+ECT+in+depression%2C+mania+and+schizophrenia&rft.au=Thirthalli%2C+Jagadisha%3BKumar%2C+Channaveerachari+Naveen%3BBangalore%2C+Ravi+P%3BGangadhar%2C+Bangalore+N&rft.aulast=Thirthalli&rft.aufirst=Jagadisha&rft.date=2009-09-01&rft.volume=117&rft.issue=1-2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2008.12.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Electroconvulsive therapy; Mania; Schizophrenia; Hospitalization; Depression; Thresholds DO - http://dx.doi.org/10.1016/j.jad.2008.12.011 ER - TY - CPAPER T1 - The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and affects development and hormone response T2 - 2009 EMBO Conference Series on Protein Synthesis and Translational Control AN - 42371853; 5379116 JF - 2009 EMBO Conference Series on Protein Synthesis and Translational Control AU - Blackshear, Perry AU - Jang, J C AU - Pomeranz, Marcelo AU - Lin, Pei-Chi AU - Hah, Cyrus AU - Kang, Shin Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 KW - Zinc finger proteins KW - Traffic KW - Hormones KW - Nuclei KW - Protein transport KW - Arabidopsis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+EMBO+Conference+Series+on+Protein+Synthesis+and+Translational+Control&rft.atitle=The+Arabidopsis+tandem+zinc+finger+protein+AtTZF1+traffics+between+the+nucleus+and+cytoplasmic+foci+and+affects+development+and+hormone+response&rft.au=Blackshear%2C+Perry%3BJang%2C+J+C%3BPomeranz%2C+Marcelo%3BLin%2C+Pei-Chi%3BHah%2C+Cyrus%3BKang%2C+Shin&rft.aulast=Blackshear&rft.aufirst=Perry&rft.date=2009-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+EMBO+Conference+Series+on+Protein+Synthesis+and+Translational+Control&rft.issn=&rft_id=info:doi/ L2 - http://www.embl.de/Conferences/TransControl/2009/TCR09AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of haploinsufficiency of ribosomal protein and assembly factor genes on cellular physiology mediated by RACK1 T2 - 2009 EMBO Conference Series on Protein Synthesis and Translational Control AN - 42369076; 5379017 JF - 2009 EMBO Conference Series on Protein Synthesis and Translational Control AU - Garfinkel, David AU - Dakshinamurthy, Arun AU - Farabaugh, Philip AU - Suresh, Susmitha Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 KW - Physiology KW - Haploinsufficiency KW - Ribosomal proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42369076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+EMBO+Conference+Series+on+Protein+Synthesis+and+Translational+Control&rft.atitle=Effects+of+haploinsufficiency+of+ribosomal+protein+and+assembly+factor+genes+on+cellular+physiology+mediated+by+RACK1&rft.au=Garfinkel%2C+David%3BDakshinamurthy%2C+Arun%3BFarabaugh%2C+Philip%3BSuresh%2C+Susmitha&rft.aulast=Garfinkel&rft.aufirst=David&rft.date=2009-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+EMBO+Conference+Series+on+Protein+Synthesis+and+Translational+Control&rft.issn=&rft_id=info:doi/ L2 - http://www.embl.de/Conferences/TransControl/2009/TCR09AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Semiparametric estimation and inference for distributional and general treatment effects AN - 37192029; 3895729 AB - There is a large literature on methods of analysis for randomized trials with non-compliance which focuses on the effect of treatment on the average outcome. The paper considers evaluating the effect of treatment on the entire distribution and general functions of this effect. For distributional treatment effects, fully non-parametric and fully parametric approaches have been proposed. The fully non-parametric approach could be inefficient but the fully parametric approach is not robust to the violation of distribution assumptions. We develop a semiparametric instrumental variable method based on the empirical likelihood approach. Our method can be applied to general outcomes and general functions of outcome distributions and allows us to predict a subject's latent compliance class on the basis of an observed outcome value in observed assignment and treatment received groups. Asymptotic results for the estimators and likelihood ratio statistic are derived. A simulation study shows that our estimators of various treatment effects are substantially more efficient than the currently used fully non-parametric estimators. The method is illustrated by an analysis of data from a randomized trial of an encouragement intervention to improve adherence to prescribed depression treatments among depressed elderly patients in primary care practices. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Cheng, J AU - Qin, J AU - Zhang, B AD - University of Florida ; National Institute of Allergy and Infectious Diseases, Bethesda ; University of Toledo Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 881 EP - 904 VL - 71 IS - 4 SN - 1369-7412, 1369-7412 KW - Sociology KW - Randomized trials KW - Treatment effects KW - Medical research KW - Data analysis KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37192029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Semiparametric+estimation+and+inference+for+distributional+and+general+treatment+effects&rft.au=Cheng%2C+J%3BQin%2C+J%3BZhang%2C+B&rft.aulast=Cheng&rft.aufirst=J&rft.date=2009-09-01&rft.volume=71&rft.issue=4&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 7886 10902; 3279 971 3286 ER - TY - JOUR T1 - Aversion to ambiguity regarding medical tests and treatments: measurement, prevalence, and relationship to sociodemographic factors AN - 37180954; 3890316 AB - Aversion to "ambiguity"-uncertainty about the reliability, credibility, or adequacy of risk-related information-is an important problem that may influence judgments and decisions about medical interventions. Ambiguity aversion (AA) varies among individuals, however, and has been understudied in the health domain. To explore this phenomenon further, we developed a new theory-based measure of aversion to ambiguity regarding medical tests and treatments, and examined the prevalence and association of AA with sociodemographic factors. The "AA-Med" scale was developed using a large survey sample of the U.S. public (n = 4,398), and scale psychometric properties and the population distribution of AA were evaluated. The scale demonstrated acceptable reliability (b1; = .73) and validity as ascertained by association with respondents' interest in a hypothetical ambiguous cancer screening test. Ambiguity aversion (AA) was associated with older age, non-White race, lower education and income, and female sex. The AA-Med scale is a promising new measure, and AA is associated with several sociodemographic factors. We discuss implications of these findings and potential applications of the scale for future research. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Han, Paul AU - Reeve, Bryce AU - Moser, Richard AU - Klein, William AD - National Cancer Institute, USA ; University of Pittsburgh Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 556 EP - 572 VL - 14 IS - 6 SN - 1081-0730, 1081-0730 KW - Sociology KW - Demographic indicators KW - Social factors KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37180954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Aversion+to+ambiguity+regarding+medical+tests+and+treatments%3A+measurement%2C+prevalence%2C+and+relationship+to+sociodemographic+factors&rft.au=Han%2C+Paul%3BReeve%2C+Bryce%3BMoser%2C+Richard%3BKlein%2C+William&rft.aulast=Han&rft.aufirst=Paul&rft.date=2009-09-01&rft.volume=14&rft.issue=6&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730903089630 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3409 6306; 10449 5772; 11839 DO - http://dx.doi.org/10.1080/10810730903089630 ER - TY - JOUR T1 - Community-Based Adaptive Physical Activity Program for Chronic Stroke: Feasibility, Safety, and Efficacy of the Empoli Model AN - 21505043; 12506811 AB - Objective. To determine whether Adaptive Physical Activity (APA-stroke), a community-based exercise program for participants with hemiparetic stroke, improves function in the community. Methods. Nonrandomized controlled study in Tuscany, Italy, of participants with mild to moderate hemiparesis at least 9 months after stroke. Forty-nine participants in a geographic health authority (Empoli) were offered APA-stroke (40 completed the study). Forty-four control participants in neighboring health authorities (Florence and Pisa) received usual care (38 completed the study). The APA intervention was a community-based progressive group exercise regimen that included walking, strength, and balance training for 1 hour, thrice a week, in local gyms, supervised by gym instructors. No serious adverse clinical events occurred during the exercise intervention. Outcome measures included the following: 6-month change in gait velocity (6-Minute Timed Walk), Short Physical Performance Battery (SPPB), Berg Balance Scale, Stroke Impact Scale (SIS), Barthel Index, Hamilton Rating Scale for Depression, and Index of Caregivers Strain. Results. After 6 months, the intervention group improved whereas controls declined in gait velocity, balance, SPPB, and SIS social participation domains. These between-group comparisons were statistically significant at P < .00015. Individuals with depressive symptoms at baseline improved whereas controls were unchanged (P < .003). Oral glucose tolerance tests were performed on a subset of participants in the intervention group. For these individuals, insulin secretion declined 29% after 6 months (P = .01). Conclusion. APA-stroke appears to be safe, feasible, and efficacious in a community setting. JF - Neurorehabilitation and Neural Repair AU - Stuart, Mary AU - Benvenuti, Francesco AU - Macko, Richard AU - Taviani, Antonio AU - Segenni, Lucianna AU - Mayer, Federico AU - Sorkin, John D AU - Stanhope, Steven J AU - Macellari, Velio AU - Weinrich, Michael AD - National Center for Medical Rehabilitation Research, NICHD, National Institutes of Health, Bethesda, Maryland, stuart@umbc.edu Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 726 EP - 734 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 23 IS - 7 SN - 1545-9683, 1545-9683 KW - CSA Neurosciences Abstracts; Physical Education Index KW - Paresis KW - Depression KW - Rehabilitation KW - Secretion KW - Physical activity KW - Stroke KW - Basic instruction program KW - Statistical analysis KW - Walking KW - Velocity KW - Exercise KW - Rating scales KW - Insulin KW - Strength (training) KW - Physical training KW - Exercise (intensity) KW - Glucose tolerance KW - gait KW - Gait KW - Balance KW - Neurology KW - PE 100:Kinesiology KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21505043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurorehabilitation+and+Neural+Repair&rft.atitle=Community-Based+Adaptive+Physical+Activity+Program+for+Chronic+Stroke%3A+Feasibility%2C+Safety%2C+and+Efficacy+of+the+Empoli+Model&rft.au=Stuart%2C+Mary%3BBenvenuti%2C+Francesco%3BMacko%2C+Richard%3BTaviani%2C+Antonio%3BSegenni%2C+Lucianna%3BMayer%2C+Federico%3BSorkin%2C+John+D%3BStanhope%2C+Steven+J%3BMacellari%2C+Velio%3BWeinrich%2C+Michael&rft.aulast=Stuart&rft.aufirst=Mary&rft.date=2009-09-01&rft.volume=23&rft.issue=7&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Neurorehabilitation+and+Neural+Repair&rft.issn=15459683&rft_id=info:doi/10.1177%2F1545968309332734 LA - English DB - Physical Education Index N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Exercise (intensity); Basic instruction program; Stroke; Velocity; Exercise; Rating scales; Gait; Balance; Strength (training); Depression; Paresis; Rehabilitation; Physical activity; Secretion; Statistical analysis; Walking; Insulin; Physical training; Glucose tolerance; gait; Neurology DO - http://dx.doi.org/10.1177/1545968309332734 ER - TY - JOUR T1 - Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjoegren's Syndrome Immunopathogenesis AN - 21330210; 11673756 AB - Recently recognized as a distinct CD4 super(+) T helper (Th) lineage, Th17 cells have been implicated in host responses to infections and in pathogenesis associated with autoimmune diseases. This cytokine is implicated in primary Sjoegren's syndrome (pSS) immunopathology because of the increased levels of circulating interleukin (IL)-17 in pSS. Plasma and minor salivary glands (MSGs) from patients with pSS were therefore evaluated for CD4 super(+) T cells, T regulatory cells, IL-17, and supporting cytokines by immunohistochemistry, RT-PCR, and microbead assays. MSGs from pSS patients contain IL-17-expressing cells as a dominant population within inflammatory lesions. IL-17 protein expression progressively increased with higher biopsy focus scores (P < 0.0001), in parallel with detection by RT-PCR. Transforming growth factor-b, IL-6 and IL-23, which are requisite promoters of Th17 differentiation, were found in abundance compared with the amounts in control tissues. Although transforming growth factor-b is also a pivotal differentiation factor for immunosuppressive Foxp3 super(+) T regulatory cells (Tregs), an increase in Foxp3 super(+) Tregs was evident in biopsy specimens with mild and moderate inflammation but this increase was disproportionate to escalating pro-inflammatory Th17 populations in advanced disease. Furthermore, the Th17-centric cytokines IL-17, IL-6, IL-23, and IL-12 were significantly elevated in pSS plasma. These data identify a profusion of IL-17-generating cells and supporting cytokines within diseased pSS MSGs without a compensatory increase in immunomodulatory Tregs; this imbalance seems to foster a pathogenic milieu that may be causative and predictive of infiltrative injury and amenable to therapeutic intervention. JF - American Journal of Pathology AU - Katsifis, GE AU - Rekka, S AU - Moutsopoulos, N M AU - Pillemer, S AU - Wahl, S M AD - Oral Infection and Immunity Branch, and Sjoegren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1167 EP - 1177 VL - 175 IS - 3 SN - 0002-9440, 0002-9440 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Interleukin 6 KW - Immunoregulation KW - Injuries KW - Helper cells KW - Autoimmune diseases KW - Therapeutic applications KW - Biopsy KW - Salivary gland KW - Infection KW - Immunomodulation KW - Sjogren's syndrome KW - Interleukin 12 KW - Promoters KW - Differentiation KW - CD4 antigen KW - Foxp3 protein KW - Interleukin 17 KW - Lymphocytes T KW - Transforming growth factor-b KW - Polymerase chain reaction KW - Data processing KW - Immunopathogenesis KW - Inflammation KW - Interleukin 23 KW - microspheres KW - Immunohistochemistry KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21330210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Systemic+and+Local+Interleukin-17+and+Linked+Cytokines+Associated+with+Sjoegren%27s+Syndrome+Immunopathogenesis&rft.au=Katsifis%2C+GE%3BRekka%2C+S%3BMoutsopoulos%2C+N+M%3BPillemer%2C+S%3BWahl%2C+S+M&rft.aulast=Katsifis&rft.aufirst=GE&rft.date=2009-09-01&rft.volume=175&rft.issue=3&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2009.090319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Immunoregulation; Injuries; Helper cells; Autoimmune diseases; Therapeutic applications; Biopsy; Infection; Salivary gland; Immunomodulation; Sjogren's syndrome; Differentiation; Promoters; Interleukin 12; CD4 antigen; Foxp3 protein; Interleukin 17; Lymphocytes T; Polymerase chain reaction; Transforming growth factor-b; Data processing; Immunopathogenesis; Inflammation; Interleukin 23; microspheres; Immunohistochemistry DO - http://dx.doi.org/10.2353/ajpath.2009.090319 ER - TY - JOUR T1 - Ion-Abrasion Scanning Electron Microscopy Reveals Surface-Connected Tubular Conduits in HIV-Infected Macrophages AN - 21327748; 11704404 AB - HIV-1-containing internal compartments are readily detected in images of thin sections from infected cells using conventional transmission electron microscopy, but the origin, connectivity, and 3D distribution of these compartments has remained controversial. Here, we report the 3D distribution of viruses in HIV-1-infected primary human macrophages using cryo-electron tomography and ion-abrasion scanning electron microscopy (IA-SEM), a recently developed approach for nanoscale 3D imaging of whole cells. Using IA-SEM, we show the presence of an extensive network of HIV-1-containing tubular compartments in infected macrophages, with diameters of a14150a200 nm, and lengths of up to a145 Amm that extend to the cell surface from vesicular compartments that contain assembling HIV-1 virions. These types of surface-connected tubular compartments are not observed in T cells infected with the 29/31 KE Gag-matrix mutant where the virus is targeted to multi-vesicular bodies and released into the extracellular medium. IA-SEM imaging also allows visualization of large sheet-like structures that extend outward from the surfaces of macrophages, which may bend and fold back to allow continual creation of viral compartments and virion-lined channels. This potential mechanism for efficient virus trafficking between the cell surface and interior may represent a subversion of pre-existing vesicular machinery for antigen capture, processing, sequestration, and presentation. Author Summary Current treatment regimens for HIV-infected individuals are not capable of eradicating HIV infection, even though combinations of highly potent antiviral drugs are used. Indeed, drug regimens must be periodically altered as the virus resurges from a persistent reservoir. Macrophages, which serve as asearch-and-destroya immune surveillance cells of the body, are now thought to be a key component of this reservoir. Evidence suggests that macrophages can harbor infectious HIV virions for long periods, and transmit them to bystander T cells. We have used a new technique called ion abrasion scanning electron microscopy (IA-SEM) to image entire HIV-infected human macrophages at a resolution high enough to see individual HIV virions and their location within the cell. This approach revealed that HIV is present in a system of nanoscale tubes, barely larger than a virus at some places, which connect internal viral reservoirs to the cell surface. These tubes could allow the macrophage to deliver HIV virions to bystander cells from its continually replenished stores of ammunition, held deep within the cell. Our work provides a glimpse of how the structure of these reservoirs allows macrophages to accomplish viral delivery. Discovery of these virion-channeling tubes provides a potential drug target to address the problem of persistent HIV infection. JF - PLoS Pathogens AU - Bennett, Adam E AU - Narayan, Kedar AU - Shi, Dan AU - Hartnell, Lisa M AU - Gousset, Karine AU - He, Haifeng AU - Lowekamp, Bradley C AU - Yoo, Terry S AU - Bliss, Donald AU - Freed, Eric O AU - Subramaniam, Sriram AU - Hope, Thomas J AD - Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, United States of America Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 5 IS - 9 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Virions KW - Macrophages KW - Scanning electron microscopy KW - Cell surface KW - Abrasion KW - Transmission electron microscopy KW - Pathogens KW - Infection KW - Antigen presentation KW - Immunosuppressive agents KW - imaging KW - Antiviral agents KW - Human immunodeficiency virus KW - Immunosurveillance KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Tomography KW - Antigen processing KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21327748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Ion-Abrasion+Scanning+Electron+Microscopy+Reveals+Surface-Connected+Tubular+Conduits+in+HIV-Infected+Macrophages&rft.au=Bennett%2C+Adam+E%3BNarayan%2C+Kedar%3BShi%2C+Dan%3BHartnell%2C+Lisa+M%3BGousset%2C+Karine%3BHe%2C+Haifeng%3BLowekamp%2C+Bradley+C%3BYoo%2C+Terry+S%3BBliss%2C+Donald%3BFreed%2C+Eric+O%3BSubramaniam%2C+Sriram%3BHope%2C+Thomas+J&rft.aulast=Bennett&rft.aufirst=Adam&rft.date=2009-09-01&rft.volume=5&rft.issue=9&rft.spage=e1000591&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000591 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; Virions; Cell surface; Scanning electron microscopy; Abrasion; Transmission electron microscopy; Pathogens; Antigen presentation; Infection; imaging; Immunosuppressive agents; Antiviral agents; Immunosurveillance; Lymphocytes T; Tomography; Antigen processing; Human immunodeficiency virus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1371/journal.ppat.1000591 ER - TY - JOUR T1 - Polyamines Are Not Required for Aerobic Growth of Escherichia coli: Preparation of a Strain with Deletions in All of the Genes for Polyamine Biosynthesis AN - 21326830; 11916938 AB - A strain of Escherichia coli was constructed in which all of the genes involved in polyamine biosynthesis-speA (arginine decarboxylase), speB (agmatine ureohydrolase), speC (ornithine decarboxylase), spe D (adenosylmethionine decarboxylase), speE (spermidine synthase), speF (inducible ornithine decarboxylase), cadA (lysine decarboxylase), and ldcC (lysine decarboxylase)-had been deleted. Despite the complete absence of all of the polyamines, the strain grew indefinitely in air in amine-free medium, albeit at a slightly (ca. 40 to 50%) reduced growth rate. Even though this strain grew well in the absence of the amines in air, it was still sensitive to oxygen stress in the absence of added spermidine. In contrast to the ability to grow in air in the absence of polyamines, this strain, surprisingly, showed a requirement for polyamines for growth under strictly anaerobic conditions. JF - Journal of Bacteriology AU - Chattopadhyay, Manas K AU - Tabor, Celia White AU - Tabor, Herbert AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, tabor@helix.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 5549 EP - 5552 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 17 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Growth rate KW - Arginine decarboxylase KW - Ornithine decarboxylase KW - Stress KW - Lysine KW - Adenosylmethionine decarboxylase KW - Anaerobic conditions KW - Agmatine KW - Spermidine synthase KW - Oxygen KW - amines KW - Spermidine KW - polyamines KW - Escherichia coli KW - Lysine decarboxylase KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21326830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Polyamines+Are+Not+Required+for+Aerobic+Growth+of+Escherichia+coli%3A+Preparation+of+a+Strain+with+Deletions+in+All+of+the+Genes+for+Polyamine+Biosynthesis&rft.au=Chattopadhyay%2C+Manas+K%3BTabor%2C+Celia+White%3BTabor%2C+Herbert&rft.aulast=Chattopadhyay&rft.aufirst=Manas&rft.date=2009-09-01&rft.volume=191&rft.issue=17&rft.spage=5549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00381-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 27 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Growth rate; Ornithine decarboxylase; Arginine decarboxylase; Adenosylmethionine decarboxylase; Lysine; Stress; Anaerobic conditions; Agmatine; Spermidine synthase; Oxygen; amines; Spermidine; polyamines; Lysine decarboxylase; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00381-09 ER - TY - JOUR T1 - Therapeutic Memory T Cells Require Costimulation for Effective Clearance of a Persistent Viral Infection AN - 21294150; 11916619 AB - Persistent viral infections are a major health concern worldwide. During persistent infection, overwhelming viral replication and the rapid loss of antiviral T-cell function can prevent immune-mediated clearance of the infection, and therapies to reanimate the immune response and purge persistent viruses have been largely unsuccessful. Adoptive immunotherapy using memory T cells is a highly successful therapeutic approach to eradicate a persistent viral infection. Understanding precisely how therapeutically administered memory T cells achieve clearance should improve our ability to terminate states of viral persistence in humans. Mice persistently infected from birth with lymphocytic choriomeningitis virus are tolerant to the pathogen at the T-cell level and thus provide an excellent model to evaluate immunotherapeutic regimens. Previously, we demonstrated that adoptively transferred memory T cells require recipient dendritic cells to effectively purge an established persistent viral infection. However, the mechanisms that reactivate and sustain memory T-cell responses during clearance of such an infection remain unclear. Here we establish that therapeutic memory T cells require CD80 and CD86 costimulatory signals to efficiently clear an established persistent viral infection in vivo. Early blockade of costimulatory pathways with CTLA-4-Fc decreased the secondary expansion of virus-specific CD8+ and CD4+ memory T cells as well as their ability to produce antiviral cytokines and purge the persistent infection. Late costimulation blockade also reduced virus-specific T-cell numbers, illustrating that sustained interactions with costimulatory molecules is required for efficient T-cell expansion. These findings indicate that antiviral memory T cells require costimulation to efficiently clear a persistent viral infection and that costimulatory pathways can be targeted to modulate the magnitude of an adoptive immunotherapeutic regimen. JF - Journal of Virology AU - Garidou, Lucile AU - Heydari, Sara AU - Truong, Phi AU - Brooks, David G AU - McGavern, Dorian B AD - National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20882, mcgavernd@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 8905 EP - 8915 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 17 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Replication KW - CD86 antigen KW - Animal models KW - Memory cells KW - Immunological memory KW - CD8 antigen KW - Pathogens KW - Persistent infection KW - Lymphocytic choriomeningitis virus KW - Birth KW - Costimulator KW - Dendritic cells KW - CD4 antigen KW - Adoptive immunotherapy KW - Lymphocytes T KW - CD80 antigen KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21294150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Therapeutic+Memory+T+Cells+Require+Costimulation+for+Effective+Clearance+of+a+Persistent+Viral+Infection&rft.au=Garidou%2C+Lucile%3BHeydari%2C+Sara%3BTruong%2C+Phi%3BBrooks%2C+David+G%3BMcGavern%2C+Dorian+B&rft.aulast=Garidou&rft.aufirst=Lucile&rft.date=2009-09-01&rft.volume=83&rft.issue=17&rft.spage=8905&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00027-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 33 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Replication; CD86 antigen; Immunological memory; Memory cells; Animal models; Pathogens; CD8 antigen; Persistent infection; Birth; Dendritic cells; Costimulator; CD4 antigen; Adoptive immunotherapy; Lymphocytes T; CD80 antigen; Lymphocytic choriomeningitis virus DO - http://dx.doi.org/10.1128/JVI.00027-09 ER - TY - JOUR T1 - Aggregatibacter actinomycetemcomitans Builds Mutualistic Biofilm Communities with Fusobacterium nucleatum and Veillonella Species in Saliva AN - 21293904; 12511355 AB - Human oral bacterial pathogens grow in attached multispecies biofilm communities. Unattached cells are quickly removed by swallowing. Therefore, surface attachment is essential for growth, and we investigated multispecies community interactions resulting in mutualistic growth on saliva as the sole nutritional source. We used two model systems, saliva-coated transferable solid-phase polystyrene pegs (peg biofilms) and flow cells with saliva-coated glass surfaces. Fluorescent antibody staining and image analysis were used to quantify the biomass in flow cells, and quantitative real-time PCR with species-specific primers was used to quantify the biomass in peg biofilms. Veillonella sp. strain PK1910, Aggregatibacter actinomycetemcomitans JP2, and Fusobacterium nucleatum ATCC 10953 were unable to grow as single species in flow cells. Only A. actinomycetemcomitans grew after 36 h when peg biofilms remained submerged in saliva from the time of inoculation. Mixed-species coaggregates were used for two- and three-species inoculation. The biomass in two-species biofilms increased in both systems when Veillonella sp. strain PK1910 was present as one of the partners. Enhanced growth of all strains was observed in three-species biofilms in flow cells. Interestingly, in flow cells F. nucleatum and A. actinomycetemcomitans exhibited mutualism, and, although F. nucleatum was unable to grow with either of the other species in the peg system, F. nucleatum stimulated the growth of Veillonella sp. and together these two organisms increased the total biomass of A. actinomycetemcomitans in three-species peg biofilms. We propose that mutualistic two-species and multispecies oral biofilm communities form in vivo and that mutualism between commensal veillonellae and late colonizing pathogens, such as aggregatibacteria, contributes to the development of periodontal disease. JF - Infection and Immunity AU - Periasamy, Saravanan AU - Kolenbrander, Paul E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, pkolenbrander@dir.nidcr.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 3542 EP - 3551 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 9 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Biofilms KW - Biomass KW - Commensals KW - Image processing KW - Inoculation KW - Mutualism KW - Pathogens KW - Periodontal diseases KW - Polymerase chain reaction KW - Primers KW - Saliva KW - polystyrene KW - swallowing KW - Fusobacterium nucleatum KW - Veillonella KW - J 02410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21293904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Aggregatibacter+actinomycetemcomitans+Builds+Mutualistic+Biofilm+Communities+with+Fusobacterium+nucleatum+and+Veillonella+Species+in+Saliva&rft.au=Periasamy%2C+Saravanan%3BKolenbrander%2C+Paul+E&rft.aulast=Periasamy&rft.aufirst=Saravanan&rft.date=2009-09-01&rft.volume=77&rft.issue=9&rft.spage=3542&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00345-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - swallowing; Commensals; Image processing; Pathogens; Biomass; Periodontal diseases; Antibodies; Mutualism; Inoculation; polystyrene; Polymerase chain reaction; Primers; Biofilms; Saliva; Veillonella; Fusobacterium nucleatum DO - http://dx.doi.org/10.1128/IAI.00345-09 ER - TY - JOUR T1 - Clinical-translational strategies for the elevation of Nm23-H1 metastasis suppressor gene expression AN - 21284816; 11771820 AB - Interruption of the tumor metastatic process is a new, thought provoking molecular target for the treatment of cancer. The Nm23-H1 metastasis suppressor gene stands as a validated molecular target owing to its reduced expression in many aggressive human tumors, and the reduction in metastatic potential invivo upon re-expression in multiple cell lines. Several compounds have been identified which elevate Nm23-H1 expression in vitro including indomethacin, g Linolenic Acid, trichostatin A, 5-aza-deoxycytidine, and high dose medroxyprogesterone acetate. Using a model of lung metastatic colonization by MDA-MB-231 human breast carcinoma cells, we demonstrated that high dose MPA reduced the formation of overt lung metastases by 37-46% and those metastases that formed were statistically smaller. A Phase II clinical trial of high dose MPA, alone or in combination with metronomic chemotherapy has recently opened. JF - Molecular and Cellular Biochemistry AU - Marshall, Jean-Claude AU - Lee, Jong Heun AU - Steeg, Patricia S AD - Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 115 EP - 120 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 329 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Linolenic acid KW - Chemotherapy KW - Statistical analysis KW - Nucleoside-diphosphate kinase KW - Tumors KW - Clinical trials KW - Gene expression KW - Trichostatin A KW - Metastases KW - Colonization KW - medroxyprogesterone acetate KW - Indomethacin KW - Breast carcinoma KW - G 07730:Development & Cell Cycle KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Clinical-translational+strategies+for+the+elevation+of+Nm23-H1+metastasis+suppressor+gene+expression&rft.au=Marshall%2C+Jean-Claude%3BLee%2C+Jong+Heun%3BSteeg%2C+Patricia+S&rft.aulast=Marshall&rft.aufirst=Jean-Claude&rft.date=2009-09-01&rft.volume=329&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1007%2Fs11010-009-0116-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Linolenic acid; Chemotherapy; Nucleoside-diphosphate kinase; Statistical analysis; Tumors; Clinical trials; Metastases; Trichostatin A; Gene expression; Colonization; medroxyprogesterone acetate; Indomethacin; Breast carcinoma DO - http://dx.doi.org/10.1007/s11010-009-0116-3 ER - TY - JOUR T1 - Workplace Exposures and the Risk of Amyotrophic Lateral Sclerosis AN - 21260503; 11702314 AB - Background Occupation has been suggested to play a role in amyotrophic lateral sclerosis (ALS) etiology, but detailed information on the importance of specific workplace exposures is lacking. Objectives Our aim was to assess the relationship between workplace exposures and the risk of ALS and to evaluate potential interactions between these exposures and smoking. Methods We conducted a caseacontrol study in New England between 1993 and 1996, comprising 109 cases and 253 controls who completed a structured interview covering occupations and workplace exposures. Unconditional logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for ALS. Analyses were conducted among the entire study population and after stratification by smoking. Results We observed a higher risk of ALS for construction workers excluding supervisors (OR = 2.9; 95% CI, 1.2a7.2) and precision metal workers (OR = 3.5; 95% CI, 1.2a10.5). Self-reported exposures to paint strippers; cutting, cooling, or lubricating oils; antifreeze or coolants; mineral or white spirits; and dry cleaning agents each appeared to be associated with a 60a90% higher risk. Specific chemicals related to a > 50% increase in risk of ALS included aliphatic chlorinated hydrocarbons, glycols, glycol ethers, and hexane. Relative risks associated with these workplace exposures and chemicals were greater among nonsmokers and persisted in mutually adjusted models. Conclusions Our data suggest that certain occupations and workplace exposures may be associated with increased risk of ALS. These results need to be confirmed in independent populations. JF - Environmental Health Perspectives AU - Fang, Fang AU - Quinlan, Patricia AU - Ye, Weimin AU - Barber, Marie K AU - Umbach, David M AU - Sandler, Dale P AU - Kamel, Freya AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1387 EP - 1392 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Risk Abstracts; CSA Neurosciences Abstracts; Environment Abstracts KW - amyotrophic lateral sclerosis KW - chemicals KW - relative risk KW - risk factors KW - workplace exposures KW - Chemicals KW - Risk assessment KW - Stratification KW - cuttings KW - Models KW - Oil KW - Smoking KW - Workers KW - USA, New England KW - Risk factors KW - Regression analysis KW - Ethers KW - Construction industry KW - Metals KW - Etiology KW - Data processing KW - Glycol ethers KW - Oils KW - Population studies KW - Antifreezes KW - Chlorinated hydrocarbons KW - Amyotrophic lateral sclerosis KW - Minerals KW - n-Hexane KW - Paints KW - ENA 13:Population Planning & Control KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21260503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Workplace+Exposures+and+the+Risk+of+Amyotrophic+Lateral+Sclerosis&rft.au=Fang%2C+Fang%3BQuinlan%2C+Patricia%3BYe%2C+Weimin%3BBarber%2C+Marie+K%3BUmbach%2C+David+M%3BSandler%2C+Dale+P%3BKamel%2C+Freya&rft.aulast=Fang&rft.aufirst=Fang&rft.date=2009-09-01&rft.volume=117&rft.issue=9&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0900580 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Metals; Etiology; Data processing; Glycol ethers; Oils; Population studies; Antifreezes; Chlorinated hydrocarbons; Models; Workers; Smoking; Amyotrophic lateral sclerosis; Risk factors; Regression analysis; Minerals; n-Hexane; Paints; Oil; Chemicals; Stratification; Ethers; cuttings; Construction industry; USA, New England DO - http://dx.doi.org/10.1289/ehp.0900580 ER - TY - JOUR T1 - Point-of-Care Testing for Disasters: Needs Assessment, Strategic Planning, and Future Design AN - 21180645; 11264872 AB - Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens found in disaster scenarios. Hurricane Katrina, the tsunami in southeast Asia, and the current influenza pandemic (H1N1, "swine flu") vividly illustrate lack of national and global preparedness. Gap analysis of current POCT devices versus survey results reveals how POCT needs can be fulfilled. Future thinking will help avoid the worst consequences of disasters on the horizon, such as extensively drug-resistant tuberculosis and pandemic influenzas. A global effort must be made to improve POC technologies to rapidly diagnose and treat patients to improve triaging, on-site decision making, and, ultimately, economic and medical outcomes. JF - Clinics in Laboratory Medicine AU - Kost, Gerald J AU - Hale, Kristin N AU - Brock, TKeith AU - Louie, Richard F AU - Gentile, Nicole L AU - Kitano, Tyler K AU - Tran, Nam K AD - Department of Pathology and Laboratory Medicine, UC Davis-LLNL Point-of-Care Technologies Center [NIBIB, NIH], Point-of-Care Testing Center for Teaching and Research (POCTxCTR), School of Medicine, University of California, 3455 Tupper Hall, Davis, CA 95616, USA, gjkost@ucdavis.edu Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 583 EP - 605 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. Orlando, FL 32887-4800 USA VL - 29 IS - 3 SN - 0272-2712, 0272-2712 KW - Microbiology Abstracts B: Bacteriology KW - Influenza KW - Decision making KW - Hurricanes KW - pandemics KW - Mycobacterium KW - Drug resistance KW - Economics KW - Tuberculosis KW - Pathogens KW - Gap analysis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21180645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+Laboratory+Medicine&rft.atitle=Point-of-Care+Testing+for+Disasters%3A+Needs+Assessment%2C+Strategic+Planning%2C+and+Future+Design&rft.au=Kost%2C+Gerald+J%3BHale%2C+Kristin+N%3BBrock%2C+TKeith%3BLouie%2C+Richard+F%3BGentile%2C+Nicole+L%3BKitano%2C+Tyler+K%3BTran%2C+Nam+K&rft.aulast=Kost&rft.aufirst=Gerald&rft.date=2009-09-01&rft.volume=29&rft.issue=3&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Clinics+in+Laboratory+Medicine&rft.issn=02722712&rft_id=info:doi/10.1016%2Fj.cll.2009.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Influenza; Hurricanes; Decision making; pandemics; Drug resistance; Economics; Tuberculosis; Pathogens; Gap analysis; Mycobacterium DO - http://dx.doi.org/10.1016/j.cll.2009.07.014 ER - TY - JOUR T1 - Employees' Perception of Workplace Health Promotion Initiatives in Taiwan: A Cross-sectional Survey of 30 Worksites AN - 21134380; 11170635 AB - The present study was to describe the input/process and evaluate the effectiveness of Taiwanese Workplace Health Promotion Initiatives based on employees' perspectives. This study employed a cross-sectional design by a structured questionnaire that was completed by 842 employees in 30 workplaces that participated in the Taiwan Workplace Health Promotion (WHP) Initiatives which supported by Ministry of Health from 2004 to 2006. The results found that the employees generally agreed that WHP improved their personal health skills. There was a lower level of agreement with respect to other input/process domains such as workplace healthy policy, workplace supportive health environments and WHP activities and services and the WHP effectiveness. With regard to the prediction of WHP effectiveness, the domain of workplace health activities/services could only predict 50.5% of the variation of the effectiveness in a regression model. Three domains of workplace -- health activities/services, personal health skills and supportive health environments -- were significantly correlated to the agree level of health promotion effectiveness. The results suggest that companies that intend initiating health promotion programs need to conduct a detailed assessment of the nature of the workplace settings and the perceptions of employees. JF - Industrial Health AU - Hsu, S-W AU - Lin, J-D AU - Lee, K-T AU - Loh, C-H AU - Yen, C-F AU - Lin, L-P AU - Chu, C M AU - Chou, Y-C AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun E. Road, Section 6, Nei-Hu, Taipei, Taiwan, jack.lin1964@gmail.com Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 551 EP - 559 VL - 47 IS - 5 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts KW - Taiwan KW - Perception KW - health promotion KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21134380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Employees%27+Perception+of+Workplace+Health+Promotion+Initiatives+in+Taiwan%3A+A+Cross-sectional+Survey+of+30+Worksites&rft.au=Hsu%2C+S-W%3BLin%2C+J-D%3BLee%2C+K-T%3BLoh%2C+C-H%3BYen%2C+C-F%3BLin%2C+L-P%3BChu%2C+C+M%3BChou%2C+Y-C&rft.aulast=Hsu&rft.aufirst=S-W&rft.date=2009-09-01&rft.volume=47&rft.issue=5&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Perception; health promotion; Working conditions; Taiwan ER - TY - JOUR T1 - Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome AN - 21097313; 11088480 JF - Journal of Allergy and Clinical Immunology AU - Melia, Elizabeth AU - Freeman, Alexandra F AU - Shea, Yvonne R AU - Hsu, Amy P AU - Holland, Steven M AU - Olivier, Kenneth N AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md, olivierk@niaid.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 617 EP - 618 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA VL - 124 IS - 3 SN - 0091-6749, 0091-6749 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mycobacterium KW - Lung KW - Infection KW - Job's syndrome KW - F 06925:Hypersensitivity KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21097313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Pulmonary+nontuberculous+mycobacterial+infections+in+hyper-IgE+syndrome&rft.au=Melia%2C+Elizabeth%3BFreeman%2C+Alexandra+F%3BShea%2C+Yvonne+R%3BHsu%2C+Amy+P%3BHolland%2C+Steven+M%3BOlivier%2C+Kenneth+N&rft.aulast=Melia&rft.aufirst=Elizabeth&rft.date=2009-09-01&rft.volume=124&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lung; Infection; Job's syndrome; Mycobacterium DO - http://dx.doi.org/10.1016/j.jaci.2009.07.007 ER - TY - JOUR T1 - Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival AN - 21082343; 11092709 AB - Microglia do not constitute a single, uniform cell population, but rather comprise cells with varied phenotypes, some which are beneficial and others that may require active regulatory control. Thus, gaining a better understanding of the heterogeneity of resident microglia responses will contribute to any interpretation regarding the impact of any such response in the brain. Microglia are the primary source of the pro-inflammatory cytokine, tumor necrosis factor (TNF) that can initiate various effects through the activation of membrane receptors. The TNF p55 receptor contains a death domain and activation normally leads to cellular apoptosis; however, under specific conditions, receptor activation can also lead to the activation of NF-B and contribute to cell survival. These divergent outcomes have been linked to receptor localization with receptor internalization leading to cell death and membrane localization supporting cell survival. A second TNF receptor, TNF p75 receptor, is normally linked to cell growth and survival, however, it can cooperate with the p55 receptor and contribute to cell death. Thus, while an elevation in TNFa in the brain is often considered an indicator of microglia activation and neuroinflammation, a number of factors come into play to determine the final outcome. Data are reviewed demonstrating that heterogeneity in morphological response of microglia and the expression of TNFa and TNF receptors are critical in identifying and characterizing neurotoxic events as they relate to neuroinflammation, neuronal damage and in stimulating neuroprotection. JF - Neurotoxicology AU - Kraft, AD AU - McPherson, CA AU - Harry, G J AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, United States, harry@niehs.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 785 EP - 793 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 30 IS - 5 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Cell survival KW - Data processing KW - Apoptosis KW - Receptor mechanisms KW - Tumor necrosis factor KW - Brain KW - Neuroprotection KW - Tumor necrosis factor-a KW - Microglia KW - Tumor necrosis factor receptors KW - Inflammation KW - Reviews KW - NF-B protein KW - Neurotoxicity KW - Cytokines KW - Signal transduction KW - X 24310:Pharmaceuticals KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21082343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Heterogeneity+of+microglia+and+TNF+signaling+as+determinants+for+neuronal+death+or+survival&rft.au=Kraft%2C+AD%3BMcPherson%2C+CA%3BHarry%2C+G+J&rft.aulast=Kraft&rft.aufirst=AD&rft.date=2009-09-01&rft.volume=30&rft.issue=5&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2009.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Data processing; Receptor mechanisms; Tumor necrosis factor; Brain; Neuroprotection; Microglia; Tumor necrosis factor-a; Tumor necrosis factor receptors; Inflammation; Reviews; Neurotoxicity; NF-B protein; Cytokines; Signal transduction DO - http://dx.doi.org/10.1016/j.neuro.2009.07.001 ER - TY - JOUR T1 - Structure of the Plasmodium falciparum Circumsporozoite Protein, a Leading Malaria Vaccine Candidate AN - 21079636; 11260384 AB - The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoite function and invasion of hepatocytes. Given its critical nature, a phase III human CSP malaria vaccine trial is ongoing. The CSP is composed of three regions as follows: an N terminus that binds heparin sulfate proteoglycans, a four amino acid repeat region (NANP), and a C terminus that contains a thrombospondin-like type I repeat (TSR) domain. Despite the importance of CSP, little is known about its structure. Therefore, recombinant forms of CSP were produced by expression in both Escherichia coli (Ec) and then refolded (EcCSP) or in the methylotrophic yeast Pichia pastoris (PpCSP) for structural analyses. To analyze the TSR domain of recombinant CSP, conformation-dependent monoclonal antibodies that recognized unfixed P. falciparum sporozoites and inhibited sporozoite invasion of HepG2 cells in vitro were identified. These monoclonal antibodies recognized all recombinant CSPs, indicating the recombinant CSPs contain a properly folded TSR domain structure. Characterization of both EcCSP and PpCSP by dynamic light scattering and velocity sedimentation demonstrated that both forms of CSP appeared as highly extended proteins (R sub(h) 4.2 and 4.58 nm, respectively). Furthermore, high resolution atomic force microscopy revealed flexible, rod-like structures with a ribbon-like appearance. Using this information, we modeled the NANP repeat and TSR domain of CSP. Consistent with the biochemical and biophysical results, the repeat region formed a rod-like structure about 21-25 nm in length and 1.5 nm in width. Thus native CSP appears as a glycosylphosphatidylinositol-anchored, flexible rod-like protein on the sporozoite surface. JF - Journal of Biological Chemistry AU - Plassmeyer, Matthew L AU - Reiter, Karine AU - Shimp, Richard L AU - Kotova, Svetlana AU - Smith, Paul D AU - Hurt, Darrell E AU - House, Brent AU - Zou, Xiaoyan AU - Zhang, Yanling AU - Hickman, Merrit AU - Uchime, Onyinyechukwu AU - Herrera, Raul AU - Nguyen, Vu AU - Glen, Jacqueline AU - Lebowitz, Jacob AU - Jin, Albert J AU - Miller, Louis H AU - MacDonald, Nicholas J AU - Wu, Yimin AU - Narum, David L AD - Malaria Vaccine Development Branch, NIAID, National Institutes of Health, Rockville, Maryland 20852 Y1 - 2009/09// PY - 2009 DA - Sep 2009 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 284 IS - 39 SN - 0021-9258, 0021-9258 KW - ASFA Aquaculture Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Human diseases KW - Hepatocytes KW - Light scattering KW - Disease control KW - Malaria KW - Public health KW - circumsporozoite protein KW - Escherichia coli KW - Sedimentation KW - Heparin KW - Monoclonal antibodies KW - atomic force microscopy KW - Sporozoites KW - Plasmodium falciparum KW - Sulfate KW - Proteoglycans KW - Recombinants KW - Vaccines KW - Pichia pastoris KW - Amino acid sequence KW - K 03330:Biochemistry KW - Q1 08587:Diseases of Cultured Organisms KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21079636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Structure+of+the+Plasmodium+falciparum+Circumsporozoite+Protein%2C+a+Leading+Malaria+Vaccine+Candidate&rft.au=Plassmeyer%2C+Matthew+L%3BReiter%2C+Karine%3BShimp%2C+Richard+L%3BKotova%2C+Svetlana%3BSmith%2C+Paul+D%3BHurt%2C+Darrell+E%3BHouse%2C+Brent%3BZou%2C+Xiaoyan%3BZhang%2C+Yanling%3BHickman%2C+Merrit%3BUchime%2C+Onyinyechukwu%3BHerrera%2C+Raul%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BLebowitz%2C+Jacob%3BJin%2C+Albert+J%3BMiller%2C+Louis+H%3BMacDonald%2C+Nicholas+J%3BWu%2C+Yimin%3BNarum%2C+David+L&rft.aulast=Plassmeyer&rft.aufirst=Matthew&rft.date=2009-09-01&rft.volume=284&rft.issue=39&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.013706 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Recombinants; Parasites; Human diseases; Monoclonal antibodies; Disease control; Malaria; Vaccines; Sedimentation; Public health; Hepatocytes; atomic force microscopy; Light scattering; Sporozoites; Sulfate; circumsporozoite protein; Proteoglycans; Heparin; Amino acid sequence; Escherichia coli; Plasmodium falciparum; Pichia pastoris DO - http://dx.doi.org/10.1074/jbc.M109.013706 ER - TY - JOUR T1 - Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases AN - 20964229; 11068287 AB - Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, and human livers, the ultrastructural similarities and differences between liver NK and NKT cells, and the regulation of liver NK and NKT cells in a variety of murine liver injury models. We also summarize recent findings about the role of NK and NKT cells in liver injury, fibrosis, and repair. In general, NK and NKT cells accelerate liver injury by producing proinflammatory cytokines and killing hepatocytes. NK cells inhibit liver fibrosis via killing early-activated and senescent-activated stellate cells and producing IFN-. In regulating liver fibrosis, NKT cells appear to be less important than NK cells as a result of hepatic NKT cell tolerance. NK cells inhibit liver regeneration by producing IFN- and killing hepatocytes; however, the role of NK cells on the proliferation of liver progenitor cells and the role of NKT cells in liver regeneration have been controversial. The emerging roles of NK/NKT cells in chronic human liver disease will also be discussed. Understanding the role of NK and NKT cells in the pathogenesis of chronic liver disease may help us design better therapies to treat patients with this disease. JF - Journal of Leukocyte Biology AU - Gao, B AU - Radaeva, S AU - Park, O AD - Section on Liver Biology, NIAAA/NIH, 5625 Fishers Lane, Room 2S-33, Bethesda, MD 20892, USA, bgao@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 513 EP - 528 VL - 86 IS - 3 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Animal models KW - Cell proliferation KW - Cytokines KW - Fibrosis KW - Hepatocytes KW - Inflammation KW - Injuries KW - Interferon KW - Leukocytes KW - Liver diseases KW - Lymphocytes T KW - Natural killer cells KW - Reviews KW - Stem cells KW - stellate cells KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20964229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Liver+natural+killer+and+natural+killer+T+cells%3A+immunobiology+and+emerging+roles+in+liver+diseases&rft.au=Gao%2C+B%3BRadaeva%2C+S%3BPark%2C+O&rft.aulast=Gao&rft.aufirst=B&rft.date=2009-09-01&rft.volume=86&rft.issue=3&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Liver diseases; Injuries; stellate cells; Hepatocytes; Fibrosis; Leukocytes; Natural killer cells; Animal models; Inflammation; Interferon; Stem cells; Reviews; Lymphocytes T; Cytokines; Cell proliferation ER - TY - JOUR T1 - A survey of across-target bioactivity results of small molecules in PubChem AN - 20957710; 10994536 AB - This work provides an analysis of across-target bioactivity results in the screening data deposited in PubChem. Two alternative approaches for grouping-related targets are used to examine a compound's across-target bioactivity. This analysis identifies compounds that are selectively active against groups of protein targets that are identical or similar in sequence. This analysis also identifies compounds that are bioactive across unrelated targets. Statistical distributions of compound' across-target selectivity provide a survey to evaluate target specificity of compounds by deriving and analyzing bioactivity profile across a wide range of biological targets for tested small molecules in PubChem. This work enables one to select target specific inhibitors, identify promiscuous compounds and better understand the biological mechanisms of target-small molecule interactions. JF - Bioinformatics AU - Han, Lianyi AU - Wang, Yanli AU - Bryant, Stephen H Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 2251 EP - 2255 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 17 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20957710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+survey+of+across-target+bioactivity+results+of+small+molecules+in+PubChem&rft.au=Han%2C+Lianyi%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Han&rft.aufirst=Lianyi&rft.date=2009-09-01&rft.volume=25&rft.issue=17&rft.spage=2251&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp380 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btp380 ER - TY - JOUR T1 - Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice AN - 20940434; 11012057 AB - NKX2-1 is a homeodomain transcription factor that is critical for genesis of the thyroid and transcription of the thyroid-specific genes. Nkx2-1-thyroid-conditional hypomorphic mice were previously developed in which Nkx2-1 gene expression is lost in 50% of the thyroid cells. Using this mouse line as compared with wild-type and Nkx2-1 heterozygous mice, a thyroid carcinogenesis study was carried out using the genotoxic carcinogen N-bis(2-hydroxypropyl)-nitrosamine (DHPN), followed by sulfadimethoxine (SDM) or the non-genotoxic carcinogen amitrole (3-amino-1,2,4-triazole). A significantly higher incidence of adenomas was obtained in Nkx2-1-thyroid-conditional hypomorphic mice as compared with the other two groups of mice only when they were treated with DHPN + SDM, but not amitrole. A bromodeoxyuridine incorporation study revealed that thyroids of the Nkx2-1-thyroid-conditional hypomorphic mice had >2-fold higher constitutive cell proliferation rate than the other two groups of mice, suggesting that this may be at least partially responsible for the increased incidence of adenoma in this mouse line after genotoxic carcinogen exposure. Thus, NKX2-1 may function to control the proliferation of thyroid follicular cells following damage by a genotoxic carcinogen. JF - Carcinogenesis AU - Hoshi, Sayuri AU - Hoshi, Nobuo AU - Okamoto, Minoru AU - Paiz, Jorge AU - Kusakabe, Takashi AU - Ward, Jerrold M AU - Kimura, Shioko AD - 1 Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, kimuras@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1614 EP - 1619 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 30 IS - 9 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Adenoma KW - Thyroid KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20940434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Role+of+NKX2-1+in+N-bis%282-hydroxypropyl%29-nitrosamine-induced+thyroid+adenoma+in+mice&rft.au=Hoshi%2C+Sayuri%3BHoshi%2C+Nobuo%3BOkamoto%2C+Minoru%3BPaiz%2C+Jorge%3BKusakabe%2C+Takashi%3BWard%2C+Jerrold+M%3BKimura%2C+Shioko&rft.aulast=Hoshi&rft.aufirst=Sayuri&rft.date=2009-09-01&rft.volume=30&rft.issue=9&rft.spage=1614&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp167 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Thyroid DO - http://dx.doi.org/10.1093/carcin/bgp167 ER - TY - JOUR T1 - Quantifying cellular interaction dynamics in 3D fluorescence microscopy data AN - 20840783; 11034311 AB - The wealth of information available from advanced fluorescence imaging techniques used to analyze biological processes with high spatial and temporal resolution calls for high-throughput image analysis methods. Here, we describe a fully automated approach to analyzing cellular interaction behavior in 3D fluorescence microscopy images. As example application, we present the analysis of drug-induced and S1P sub(1)-knockout-related changes in bone-osteoclast interactions. Moreover, we apply our approach to images showing the spatial association of dendritic cells with the fibroblastic reticular cell network within lymph nodes and to microscopy data regarding T- B lymphocyte synapse formation. Such analyses that yield important information about the molecular mechanisms determining cellular interaction behavior would be very difficult to perform with approaches that rely on manual/semi-automated analyses. This protocol integrates adaptive threshold segmentation, object detection, adaptive color channel merging, and neighborhood analysis and permits rapid, standardized, quantitative analysis and comparison of the relevant features in large data sets. JF - Nature Protocols AU - Klauschen, Frederick AU - Ishii, Masaru AU - Qi, Hai AU - Bajenoff, Marc AU - Egen, Jackson G AU - Germain, Ronald N AU - Meier-Schellersheim, Martin AD - Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., fklauschen@mail.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1305 EP - 1311 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 9 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Cell and developmental biology KW - Computational and theoretical biology KW - Imaging KW - Dendritic cells KW - Molecular modelling KW - Data processing KW - Synaptogenesis KW - Lymphocytes B KW - Segmentation KW - Image processing KW - imaging KW - Lymph nodes KW - Color KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20840783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Quantifying+cellular+interaction+dynamics+in+3D+fluorescence+microscopy+data&rft.au=Klauschen%2C+Frederick%3BIshii%2C+Masaru%3BQi%2C+Hai%3BBajenoff%2C+Marc%3BEgen%2C+Jackson+G%3BGermain%2C+Ronald+N%3BMeier-Schellersheim%2C+Martin&rft.aulast=Klauschen&rft.aufirst=Frederick&rft.date=2009-09-01&rft.volume=4&rft.issue=9&rft.spage=1305&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2009.129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Dendritic cells; Data processing; Lymphocytes B; Synaptogenesis; Segmentation; Image processing; imaging; Lymph nodes; Color DO - http://dx.doi.org/10.1038/nprot.2009.129 ER - TY - JOUR T1 - Cryo-electron tomography of bacteria: progress, challenges and future prospects AN - 20801603; 10915431 AB - Recent advances in three-dimensional electron microscopy provide remarkable tools to image the interior of bacterial cells. Glimpses of cells at resolutions that are 1-2 orders of magnitude higher than those currently attained with light microscopy can now be obtained with cryo-electron tomography, especially when used in combination with new tools for image averaging. This Review highlights recent advances in this area and provides an assessment of the general applicability, current limitations and type of structural information that can be obtained about the organization of intact cells using tomography. Possible future directions for whole cell imaging are also discussed. JF - Nature Reviews: Microbiology AU - Milne, Jacqueline LS AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 666 EP - 675 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 7 IS - 9 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Tomography KW - imaging KW - Electron microscopy KW - J 02490:Miscellaneous KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20801603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=Cryo-electron+tomography+of+bacteria%3A+progress%2C+challenges+and+future+prospects&rft.au=Milne%2C+Jacqueline+LS%3BSubramaniam%2C+Sriram&rft.aulast=Milne&rft.aufirst=Jacqueline&rft.date=2009-09-01&rft.volume=7&rft.issue=9&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2183 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tomography; imaging; Electron microscopy DO - http://dx.doi.org/10.1038/nrmicro2183 ER - TY - JOUR T1 - Oesophageal cancer incidence in the United States by race, sex, and histologic type, 1977-2005 AN - 20801372; 10915086 AB - Background:In the United States, the rates and temporal trends of oesophageal cancer overall and for the two predominant histologic types - adenocarcinoma (ADC) and squamous cell carcinoma (SCC) - differ between Blacks and Whites, but little is known with regard to the patterns among Asians/Pacific Islanders or Hispanics. Methods:Using the Surveillance, Epidemiology, and End Results programme data, we analysed oesophageal cancer incidence patterns by race, sex, and histologic type for the period 1977-2005. Results:Total oesophageal cancer incidence has been increasing among Whites only; the rates among all other race groups have declined. Moreover, rates among White men surpassed those among Blacks in 2004. Oesophageal SCC rates have been decreasing among virtually all racial/ethnic groups; rates among Hispanic and Asian/Pacific Islander men have been intermediate to those of Blacks and Whites, with rates among women being lower than those among Blacks or Whites. The ADC rates among Hispanic men may be rising, akin to the historical trends among Whites and Blacks. The sex ratios for these cancers also varied markedly. Conclusions:These observations may provide clues for aetiological research. JF - British Journal of Cancer AU - Cook, M B AU - Chow, W-H AU - Devesa, S S AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 855 EP - 859 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Historical account KW - USA KW - I, Pacific KW - sex ratio KW - Ethnic groups KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20801372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Oesophageal+cancer+incidence+in+the+United+States+by+race%2C+sex%2C+and+histologic+type%2C+1977-2005&rft.au=Cook%2C+M+B%3BChow%2C+W-H%3BDevesa%2C+S+S&rft.aulast=Cook&rft.aufirst=M&rft.date=2009-09-01&rft.volume=101&rft.issue=5&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605246 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; I, Pacific; Cancer; Historical account; Ethnic groups; sex ratio DO - http://dx.doi.org/10.1038/sj.bjc.6605246 ER - TY - JOUR T1 - Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma AN - 20795427; 10844036 AB - Identification of tumor-derived proteins in the circulation may allow for early detection of cancer and evaluation of therapeutic responses. To identify circulating tumor-derived proteins, mice were immunized with concentrated culture medium conditioned by human breast cancer cells. Antibodies generated by hybridomas were screened against conditioned media from both normal epithelial cells and tumor cells. Antibody selectively reacting with tumor cell-conditioned media was further characterized. This led to the development of a monoclonal antibody (Alper-p280) that reacts with a newly identified 280-kDa secreted variant of human filamin-A. Circulating filamin-A was detected in patient plasma samples using Alper-p280 in an ELISA assay. Human plasma samples from 134 patients with brain, breast, or ovarian cancer, 15 patients with active arthritis, and 76 healthy controls were analyzed. Filamin-A protein levels in human cell lines and tissues were analyzed by western blotting, immunohistochemistry, and electron and confocal microscopy. Circulating filamin-A was detected in the plasma of 109 of 143 patients with breast cancer and primary brain tumors. Plasma levels of filamin-A showed 89.5% sensitivity (95% confidence interval [CI] = 0.67% to 0.99%) and 97.8% specificity (95% CI = 0.88% to 0.99%) for glioblastoma at a cut-off of 21.0 ng/mL. Plasma levels of filamin-A (>36.0 ng/mL) had 96.7% sensitivity (95% CI = 0.80% to 0.99%) and 67.8% specificity (95% CI = 0.54% to 0.79%) for metastatic breast cancer. Filamin-A levels were increased in malignant breast or brain tissues, but not in normal control tissues. Filamin-A localized to lysosomes in MDA.MB.231 breast cancer cells, but not in normal human mammary epithelial cells, suggesting that filamin-A may undergo cancer-specific processing. Plasma filamin-A appears to be a specific and sensitive marker for patients with high-grade astrocytoma or metastatic breast cancer. Additional novel cancer biomarkers have been identified and are being developed alongside Alper-p280 for use in diagnosis of breast carcinoma and high-grade astrocytoma, and for use in the evaluation of therapeutic responses. (Cancer Sci 2009; 100: 1748-1756) JF - Cancer Science AU - Alper, Oezge AU - Stetler-Stevenson, William G AU - Harris, Lyndsay N AU - Leitner, Wolfgang W AU - Oezdemirli, Metin AU - Hartmann, Dan AU - Raffeld, Mark AU - Abu-Asab, Mones AU - Byers, Stephen AU - Zhuang, Zhengping AU - Oldfield, Edward H AU - Tong, Yanhe AU - Bergmann-Leitner, Elke AU - Criss, Wayne E AU - Nagasaki, Koichi AU - Mok, Samuel C AU - Cramer, Daniel W AU - Karaveli, FSeyda AU - Goldbach-Mansky, Raphaela AU - Leo, Paul AU - Stromberg, Kurt AU - Weil, Robert J AD - 15National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1748 EP - 1756 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 100 IS - 9 SN - 1347-9032, 1347-9032 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Western blotting KW - Epithelial cells KW - Glioblastoma KW - Enzyme-linked immunosorbent assay KW - Astrocytoma KW - Mammary gland KW - Monoclonal antibodies KW - Cell culture KW - biomarkers KW - Tumor cells KW - Metastases KW - Hybridoma KW - Brain tumors KW - Plasma levels KW - Arthritis KW - Confocal microscopy KW - Breast carcinoma KW - Immunohistochemistry KW - Media (culture) KW - Lysosomes KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20795427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Science&rft.atitle=Novel+anti-filamin-A+antibody+detects+a+secreted+variant+of+filamin-A+in+plasma+from+patients+with+breast+carcinoma+and+high-grade+astrocytoma&rft.au=Alper%2C+Oezge%3BStetler-Stevenson%2C+William+G%3BHarris%2C+Lyndsay+N%3BLeitner%2C+Wolfgang+W%3BOezdemirli%2C+Metin%3BHartmann%2C+Dan%3BRaffeld%2C+Mark%3BAbu-Asab%2C+Mones%3BByers%2C+Stephen%3BZhuang%2C+Zhengping%3BOldfield%2C+Edward+H%3BTong%2C+Yanhe%3BBergmann-Leitner%2C+Elke%3BCriss%2C+Wayne+E%3BNagasaki%2C+Koichi%3BMok%2C+Samuel+C%3BCramer%2C+Daniel+W%3BKaraveli%2C+FSeyda%3BGoldbach-Mansky%2C+Raphaela%3BLeo%2C+Paul%3BStromberg%2C+Kurt%3BWeil%2C+Robert+J&rft.aulast=Alper&rft.aufirst=Oezge&rft.date=2009-09-01&rft.volume=100&rft.issue=9&rft.spage=1748&rft.isbn=&rft.btitle=&rft.title=Cancer+Science&rft.issn=13479032&rft_id=info:doi/10.1111%2Fj.1349-7006.2009.01244.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Glioblastoma; Epithelial cells; Western blotting; Ovarian cancer; Enzyme-linked immunosorbent assay; Astrocytoma; Monoclonal antibodies; Mammary gland; Cell culture; Tumor cells; biomarkers; Brain tumors; Hybridoma; Metastases; Plasma levels; Arthritis; Confocal microscopy; Breast carcinoma; Immunohistochemistry; Lysosomes; Media (culture) DO - http://dx.doi.org/10.1111/j.1349-7006.2009.01244.x ER - TY - JOUR T1 - Malaria vaccine trial endpoints - bridging the gaps between trial design, public health and the next generation of vaccines AN - 20790866; 10846064 AB - SummaryA recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission. Here, we discuss the gaps that this approach leaves in predicting the potential public health impact of a vaccine and the challenges faced by vaccine trial designers. We examine the implications of current vaccine trial design on effectiveness studies and the next generation of malaria vaccines. JF - Parasite Immunology AU - O'Meara, W P AU - Lang, T AD - 1Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 574 EP - 581 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 31 IS - 9 SN - 0141-9838, 0141-9838 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts KW - Parasites KW - Human diseases KW - Organizations KW - Immunology KW - Leaves KW - Disease control KW - Malaria KW - Clinical trials KW - Public health KW - Disease transmission KW - Vaccines KW - Q1 08587:Diseases of Cultured Organisms KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q3 08587:Diseases of Cultured Organisms KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20790866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Parasite+Immunology&rft.atitle=Malaria+vaccine+trial+endpoints+-+bridging+the+gaps+between+trial+design%2C+public+health+and+the+next+generation+of+vaccines&rft.au=O%27Meara%2C+W+P%3BLang%2C+T&rft.aulast=O%27Meara&rft.aufirst=W&rft.date=2009-09-01&rft.volume=31&rft.issue=9&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Parasite+Immunology&rft.issn=01419838&rft_id=info:doi/10.1111%2Fj.1365-3024.2009.01144.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Organizations; Immunology; Disease control; Malaria; Vaccines; Disease transmission; Public health; Leaves; Clinical trials DO - http://dx.doi.org/10.1111/j.1365-3024.2009.01144.x ER - TY - JOUR T1 - Correlations between microbial indicators, pathogens, and environmental factors in a subtropical Estuary AN - 20786511; 10849565 AB - The objective of this study was to evaluate whether indicator microbes and physical-chemical parameters were correlated with pathogens within a tidally influenced Estuary. Measurements included the analysis of physical-chemical parameters (pH, salinity, temperature, and turbidity), measurements of bacterial indicators (enterococci, fecal coliform, Escherichia coli, and total coliform), viral indicators (somatic and MS2 coliphage), viral pathogens (enterovirus by culture), and protozoan pathogens (Cryptosporidium and Giardia). All pathogen results were negative with the exception of one sample which tested positive for culturable reovirus (8.5MPN/100L). Notable physical-chemical parameters for this sample included low salinity (<1ppt) and high water temperature (31 super(o)C). Indicator bacteria and indicator virus levels for this sample were within average values typically measured within the study site and were low in comparison with levels observed in other freshwater environments. Overall results suggest that high levels of bacterial and viral indicators were associated with low salinity sites. JF - Marine Pollution Bulletin AU - Ortega, C AU - Solo-Gabriele, H M AU - Abdelzaher, A AU - Wright, M AU - Deng, Y AU - Stark, L M AD - NSF NIEHS Oceans and Human Health Center, Key Biscayne, FL 33149, USA, hmsolo@miami.edu Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1374 EP - 1381 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 58 IS - 9 SN - 0025-326X, 0025-326X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Environment Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts KW - Indicators KW - Microbial contamination KW - Public health KW - Giardia KW - Salinity KW - Escherichia coli KW - Biological pollutants KW - pH effects KW - pH KW - environmental factors KW - Pathogenic bacteria KW - Freshwater environments KW - Estuaries KW - Brackish KW - Water temperature KW - Turbidity KW - Reovirus KW - Environmental factors KW - Salinity effects KW - Temperature effects KW - Bacteria KW - Fecal coliforms KW - Coliforms KW - Temperature KW - Pathogens KW - Enterovirus KW - Marine pollution KW - Cryptosporidium KW - Cultures KW - water temperature KW - K 03340:Effects of Physical & Chemical Factors KW - SW 3010:Identification of pollutants KW - A 01450:Environmental Pollution & Waste Treatment KW - P 1000:MARINE POLLUTION KW - ENA 12:Oceans & Estuaries KW - AQ 00003:Monitoring and Analysis of Water and Wastes KW - Q5 08524:Public health, medicines, dangerous organisms KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20786511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Correlations+between+microbial+indicators%2C+pathogens%2C+and+environmental+factors+in+a+subtropical+Estuary&rft.au=Ortega%2C+C%3BSolo-Gabriele%2C+H+M%3BAbdelzaher%2C+A%3BWright%2C+M%3BDeng%2C+Y%3BStark%2C+L+M&rft.aulast=Ortega&rft.aufirst=C&rft.date=2009-09-01&rft.volume=58&rft.issue=9&rft.spage=1374&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2009.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Marine pollution; Estuaries; Biological pollutants; Microbial contamination; Pathogens; Turbidity; Public health; Temperature effects; Coliforms; Fecal coliforms; Freshwater environments; Salinity effects; Water temperature; Environmental factors; pH effects; environmental factors; Salinity; Temperature; water temperature; pH; Bacteria; Cultures; Indicators; Giardia; Reovirus; Enterovirus; Cryptosporidium; Escherichia coli; Brackish DO - http://dx.doi.org/10.1016/j.marpolbul.2009.04.015 ER - TY - JOUR T1 - Role of dopamine D sub(1)-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats AN - 20774321; 10839754 AB - Rationale: In humans, exposure to environmental contexts previously associated with heroin intake can provoke relapse to drug use. In rats, exposure to heroin-associated contexts after extinction of drug-reinforced responding in different contexts reinstates heroin seeking. This effect is attenuated by blockade of D sub(1)-family receptors in lateral or medial accumbens shell, but not accumbens core. Objectives: In this study, we further characterized the role of striatal D sub(1)-family receptors in context-induced reinstatement by assessing the effect of dorsolateral or dorsomedial injections of the D sub(1)-family receptor antagonist SCH 23390 on this reinstatement. Materials and methods: Rats were trained to self-administer heroin (0.05-0.10mg/kg per infusion) for 12days; drug infusions were paired with a discrete tone-light cue. Subsequently, heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a nondrug context. During reinstatement tests under extinction conditions, the D sub(1)-family receptor antagonist SCH 23390 (0.3-1.0kg per side) was injected into the dorsolateral or dorsomedial striatum prior to exposure to heroin self-administration context or the nondrug (extinction) context. We then used a disconnection procedure to examine whether D sub(1)-family receptors in the dorsolateral striatum and lateral accumbens shell jointly or independently support context-induced reinstatement. Results: Dorsolateral but not dorsomedial SCH 23390 injections attenuated context-induced reinstatement of heroin seeking. SCH 23390 injections into the dorsolateral striatum of one hemisphere and lateral accumbens shell of the other hemisphere were ineffective. Conclusions: Results indicate that dorsolateral striatum D sub(1)-family dopamine receptors are critical for context-induced reinstatement of heroin seeking. Results also suggest that D sub(1)-receptor-mediated dopamine transmission in the dorsolateral striatum and lateral accumbens shell independently support this reinstatement. JF - Psychopharmacology AU - Bossert, Jennifer M AU - Wihbey, Kristina A AU - Pickens, Charles L AU - Nair, Sunila G AU - Shaham, Yavin Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 51 EP - 60 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 206 IS - 1 SN - 0033-3158, 0033-3158 KW - Animal Behavior Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Extinction KW - Heroin KW - Neostriatum KW - Dopamine D1 receptors KW - Drug abuse KW - Dopamine receptors KW - Reinstatement KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20774321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Role+of+dopamine+D+sub%281%29-family+receptors+in+dorsolateral+striatum+in+context-induced+reinstatement+of+heroin+seeking+in+rats&rft.au=Bossert%2C+Jennifer+M%3BWihbey%2C+Kristina+A%3BPickens%2C+Charles+L%3BNair%2C+Sunila+G%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2009-09-01&rft.volume=206&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-009-1580-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Extinction; Heroin; Neostriatum; Dopamine D1 receptors; Dopamine receptors; Drug abuse; Reinstatement; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-009-1580-x ER - TY - JOUR T1 - Objective monitoring of physical activity in children: considerations for instrument selection AN - 20708814; 10896339 AB - There has been a rapid recent increase in both the number and type of objective physical activity (PA) assessment instruments which are commercially available to researchers, practitioners, and consumers. Although this has provided improved capacity for PA assessment, it also presents a somewhat bewildering range of options related to instrument selection for users of these technologies. The purpose of this review is to provide a primer to guide selection of instruments for the objective monitoring of children's PA. In an effort to inform without overwhelming, it is not intended to be exhaustive in terms of all available instruments. A general overview is provided of two primary categories of objective monitors: pedometers and accelerometers. Within each category we focus on distinctly relevant options and features important to consider during instrument selection. In general, the desired outcome measure will determine the specific instrument category, options, and features from which the ultimate instrument choice is made. Other considerations include evidence of validity and reliability, cost, computer interface and download options, memory capacity, data aggregation and storage methods, and general participant and researcher burden associated with instrument use. There is no single objective PA assessment instrument that is appropriate for all situations, populations, and research questions. Further, we can anticipate that the commercial nature of these instruments will drive an even greater range of features and options in the future, increasing both the opportunity and the challenge for objectively assessing PA in children. JF - Journal of Science and Medicine in Sport AU - McClain, James J AU - Tudor-Locke, Catrine AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, United States, james.mcclain@nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 526 EP - 533 PB - Sports Medicine, Australia, PO Box 897 Belconnen ACT 2616 Australia, [URL:http://www.sma.org.au] VL - 12 IS - 5 SN - 1440-2440, 1440-2440 KW - Physical Education Index KW - Evaluation KW - Memory KW - Computers KW - Reliability KW - Objectives KW - Validity KW - Sport science KW - Exercise KW - Children KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20708814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Science+and+Medicine+in+Sport&rft.atitle=Objective+monitoring+of+physical+activity+in+children%3A+considerations+for+instrument+selection&rft.au=McClain%2C+James+J%3BTudor-Locke%2C+Catrine&rft.aulast=McClain&rft.aufirst=James&rft.date=2009-09-01&rft.volume=12&rft.issue=5&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Journal+of+Science+and+Medicine+in+Sport&rft.issn=14402440&rft_id=info:doi/10.1016%2Fj.jsams.2008.09.012 LA - English DB - Physical Education Index N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Objectives; Evaluation; Children; Exercise; Validity; Reliability; Computers; Sport science; Memory DO - http://dx.doi.org/10.1016/j.jsams.2008.09.012 ER - TY - JOUR T1 - Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77-JFH1 chimeric infectious virus particles AN - 20702619; 10845393 AB - Summary. Cell entry by enveloped viruses is mediated by viral glycoproteins, and generally involves a short hydrophobic peptide (fusion peptide) that inserts into the cellular membrane. An internal hydrophobic domain within E1 (aa262-290) of hepatitis C virus (HCV) may function as a fusion peptide. Retrovirus-based HCV-pseudotyped viruses (HCVpp; genotype 1a) containing Ala or Pro substitutions at conserved amino acid positions within this putative fusion peptide were generated. Mutation of conserved residues significantly reduced efficiency of HCVpp entry into Huh-7 cells. The majority of amino acid substitutions appeared to disrupt necessary interactions between E1 and E2. For some mutants, reductions in HCVpp-associated E1 were associated with the incorporation of a high molecular weight, hyperglycosylated E2 that displayed decreased CD81-binding. Other entry-deficient mutants displayed normal E1E2 incorporation into pseudoparticles and normal CD81-binding, and therefore might affect viral fusion. One mutant (S283P) consistently displayed two- to threefold higher infectivity than did wild-type. Three mutations that decreased HCVpp infectivity also reduced levels of HCVcc infectious virus production. However, the S283P mutation had a different effect in the two systems as it did not increase production of infectious HCVcc. This comprehensive mutational analysis of the putative HCV fusion peptide provides insight into the role of E1 in its interaction with E2 and in HCV entry. JF - Journal of Viral Hepatitis AU - Russell, R S AU - Kawaguchi, K AU - Meunier, J-C AU - Takikawa, S AU - Faulk, K AU - Bukh, J AU - Purcell, R H AU - Emerson, SU AD - 1Hepatitis Viruses, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 621 EP - 632 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 9 SN - 1352-0504, 1352-0504 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - glycoprotein KW - glycosylation KW - HCV entry KW - HCVcc KW - HCVpp KW - hepatitis C virus KW - Infectivity KW - Amino acid substitution KW - Hepatitis C virus KW - Hydrophobicity KW - Glycoproteins KW - Genotypes KW - Mutation KW - W 30940:Products KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20702619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Viral+Hepatitis&rft.atitle=Mutational+analysis+of+the+hepatitis+C+virus+E1+glycoprotein+in+retroviral+pseudoparticles+and+cell-culture-derived+H77-JFH1+chimeric+infectious+virus+particles&rft.au=Russell%2C+R+S%3BKawaguchi%2C+K%3BMeunier%2C+J-C%3BTakikawa%2C+S%3BFaulk%2C+K%3BBukh%2C+J%3BPurcell%2C+R+H%3BEmerson%2C+SU&rft.aulast=Russell&rft.aufirst=R&rft.date=2009-09-01&rft.volume=16&rft.issue=9&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Journal+of+Viral+Hepatitis&rft.issn=13520504&rft_id=info:doi/10.1111%2Fj.1365-2893.2009.01111.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Infectivity; Amino acid substitution; Hydrophobicity; Genotypes; Glycoproteins; Mutation; Hepatitis C virus DO - http://dx.doi.org/10.1111/j.1365-2893.2009.01111.x ER - TY - JOUR T1 - Modafinil for the treatment of cocaine dependence AN - 20696168; 10280402 AB - Aim - Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo. Methods - This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 treatment-seekers randomized, having a diagnosis of cocaine dependence; 72 participants were randomized to placebo, 69 to modafinil 200 mg, and 69 to modafinil 400 mg, taken once daily on awakening. Participants came to the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy weekly. The primary outcome measure was the weekly percentage of cocaine non-use days. Results - The GEE regression analysis showed that for the total sample, there was no significant difference between either modafinil group and placebo in the change in average weekly percent of cocaine non-use days over the 12-week treatment period (p > 0.79). However, two secondary outcomes showed significant effects by modafinil 200 mg: the maximum number of consecutive non-use days for cocaine (p = 0.02), and a reduction in craving (p = 0.04). Also, a post hoc analysis showed a significant effect of modafinil that increased the weekly percentage of non-use days in the subgroup of those cocaine patients who did not have a history of alcohol dependence (p < 0.02). Conclusions - These data suggest that modafinil, in combination with individual behavioral therapy, was effective for increasing cocaine non-use days in participants without co-morbid alcohol dependence, and in reducing cocaine craving. JF - Drug and Alcohol Dependence AU - Anderson, Ann L AU - Reid, Malcolm S AU - Li, Shou-Hua AU - Holmes, Tyson AU - Shemanski, Lynn AU - Slee, April AU - Smith, Edwina V AU - Kahn, Roberta AU - Chiang, Nora AU - Vocci, Frank AU - Ciraulo, Domenic AU - Dackis, Charles AU - Roache, John D AU - Salloum, Ihsan M AU - Somoza, Eugene AU - Urschel, Harold C AU - Elkashef, Ahmed M AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9551, United States, aa135m@nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 133 EP - 139 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 104 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20696168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Modafinil+for+the+treatment+of+cocaine+dependence&rft.au=Anderson%2C+Ann+L%3BReid%2C+Malcolm+S%3BLi%2C+Shou-Hua%3BHolmes%2C+Tyson%3BShemanski%2C+Lynn%3BSlee%2C+April%3BSmith%2C+Edwina+V%3BKahn%2C+Roberta%3BChiang%2C+Nora%3BVocci%2C+Frank%3BCiraulo%2C+Domenic%3BDackis%2C+Charles%3BRoache%2C+John+D%3BSalloum%2C+Ihsan+M%3BSomoza%2C+Eugene%3BUrschel%2C+Harold+C%3BElkashef%2C+Ahmed+M&rft.aulast=Anderson&rft.aufirst=Ann&rft.date=2009-09-01&rft.volume=104&rft.issue=1-2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.04.015 ER - TY - JOUR T1 - Human antibody titers to Epstein-Barr Virus (EBV) gp350 correlate with neutralization of infectivity better than antibody titers to EBV gp42 using a rapid flow cytometry-based EBV neutralization assay AN - 20229553; 10307271 AB - Measurement of neutralizing antibodies to Epstein-Barr virus (EBV) is important for evaluation of candidate vaccines. The current neutralization assay is based on antibody inhibition of EBV transformation of B cells and requires 6 weeks to perform. We developed a rapid, quantitative flow cytometry assay and show that neutralizing antibody titers measured by the new assay strongly correlate with antibody titers in the standard transformation-based assay. Antibodies to EBV gp350 and gp42 have been shown to block infection of B cells by EBV. Using new assays to quantify antibodies to these glycoproteins, we show for the first time that human plasma contains high titers of antibody to gp42; these titers correlate with neutralization of EBV infectivity or transformation. Furthermore, we show that antibody titers to EBV gp350 correlate more strongly with neutralization than antibody titers to gp42. These assays should be useful in accessing antibody responses to candidate EBV vaccines. JF - Virology AU - Sashihara, J AU - Burbelo, P D AU - Savoldo, B AU - Pierson, T C AU - Cohen, JI AD - Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, jcohen@niaid.nih.gov Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 249 EP - 256 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 391 IS - 2 SN - 0042-6822, 0042-6822 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Transformation KW - Flow cytometry KW - Epstein-Barr virus KW - Antibodies KW - Infectivity KW - Lymphocytes B KW - Vaccines KW - Glycoproteins KW - Infection KW - W 30925:Genetic Engineering KW - V 22300:Methods KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20229553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Human+antibody+titers+to+Epstein-Barr+Virus+%28EBV%29+gp350+correlate+with+neutralization+of+infectivity+better+than+antibody+titers+to+EBV+gp42+using+a+rapid+flow+cytometry-based+EBV+neutralization+assay&rft.au=Sashihara%2C+J%3BBurbelo%2C+P+D%3BSavoldo%2C+B%3BPierson%2C+T+C%3BCohen%2C+JI&rft.aulast=Sashihara&rft.aufirst=J&rft.date=2009-09-01&rft.volume=391&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2009.06.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Transformation; Infectivity; Antibodies; Lymphocytes B; Glycoproteins; Vaccines; Infection; Epstein-Barr virus DO - http://dx.doi.org/10.1016/j.virol.2009.06.013 ER - TY - JOUR T1 - Clonal CD27 super(+) CD19 super(+) B Cell Expansion through Inhibition of FC gamma IIR in HCV super(+) Cryoglobulinemic Patients AN - 1780515381; PQ0002828457 AB - Persistent HCV infection may be associated with extrahepatic manifestations such as type II mixed cryoglobulinemia (II-MC), a clonal B cell proliferative disorder. In persistent HCV infection without II-MC, an increase in serum immunoglobulins (Ig) is commonly observed. This increase is polyclonal and is determined primarily by increased levels of IgG which include both HCV-specific and nonspecific antibodies. Nonetheless, memory CD27 super(+) B cells do not accumulate. This paradoxical phenomenon depends on heightened sensitivity of memory B cells to BCR-independent noncognate T cell help, which speeds up their terminal differentiation into antibody-secreting cells and makes them more prone to apoptosis. In persistent HCV infection with II-MC, serum Ig elevation is also a general occurrence, and characteristically includes IgM antibodies with rheumatoid factor activity, which are essential for the development of circulating, cryoprecipitable immune complexes. Hypergammaglobulinemia is sustained by a peripheral expansion of IgM super(+)k super(+)IgD super(low/neg)CD21 super(low)CD27 super(+) B cells. These cells exhibit marked V sub(H), J sub(H), and V sub(K) gene segment usage restriction, indicating that a limited number of antigens drive their proliferation through BCR interaction. Recently, two epitopes, one of the human IgG and the second of the HCV sub(NS3) protein, had been identified and demonstrated able to link the BCR exposed on II-MC subjects. Based on the above findings, we propose a model whereby BCR binding the IgM/IgG/HCV sub(NS3) immune complexes deprives Fc gamma IIR of its natural ligand. This takes the brake off RF super(+)CD27 super(+) B cell proliferation and promotes their selective accumulation, which is otherwise prevented by increased apoptosis susceptibility in persistent HCV infection without II-MC. JF - Annals of the New York Academy of Sciences AU - De Re, Valli AU - Pavan, Alessandro AU - Sansonno, Silvia AU - Sansonno, Domenico AU - Racanelli, Vito AD - Experimental and Clinical Pharmacology Unit, DOMERT, Molecular Oncology and Translational Research Department, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano (PN), Italy. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 326 EP - 333 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 1173 IS - 1 SN - 0077-8923, 0077-8923 KW - Immunology Abstracts; Environment Abstracts KW - Sensitivity KW - Hepatitis C virus KW - Proteins KW - Hepatitis C KW - Infection KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780515381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Clonal+CD27+super%28%2B%29+CD19+super%28%2B%29+B+Cell+Expansion+through+Inhibition+of+FC+gamma+IIR+in+HCV+super%28%2B%29+Cryoglobulinemic+Patients&rft.au=De+Re%2C+Valli%3BPavan%2C+Alessandro%3BSansonno%2C+Silvia%3BSansonno%2C+Domenico%3BRacanelli%2C+Vito&rft.aulast=De+Re&rft.aufirst=Valli&rft.date=2009-09-01&rft.volume=1173&rft.issue=1&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.04664.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Sensitivity; Proteins; Hepatitis C; Infection; Hepatitis C virus DO - http://dx.doi.org/10.1111/j.1749-6632.2009.04664.x ER - TY - JOUR T1 - OC28.05: Sonographic "sludge" and "pseudo-sludge": microbiologic, molecular, immunologic and histologic features AN - 1022565030; 15271176 AB - No abstract is available for this article. JF - Vol. 34, no. S1, [np]. Sep 2009. AU - Kusanovic, J AU - Romero, R AU - Mittal, P AU - Nhan-Chang, C L AU - Vaisbuch, E AU - Erez, O AU - Kim, C J AU - Goncalves, L AU - Mazaki-Tovi, S AU - Chaiworapongsa, T AU - Gotsch, F AU - Yeo, L AU - Hassan, S AD - NICHD/NIH/DHHS, Perinatology Research Branch, Detroit, MI, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 VL - 34 IS - S1 SN - 1469-0705, 1469-0705 KW - Microbiology Abstracts A: Industrial & Applied Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022565030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=OC28.05%3A+Sonographic+%22sludge%22+and+%22pseudo-sludge%22%3A+microbiologic%2C+molecular%2C+immunologic+and+histologic+features&rft.au=Kusanovic%2C+J%3BRomero%2C+R%3BMittal%2C+P%3BNhan-Chang%2C+C+L%3BVaisbuch%2C+E%3BErez%2C+O%3BKim%2C+C+J%3BGoncalves%2C+L%3BMazaki-Tovi%2C+S%3BChaiworapongsa%2C+T%3BGotsch%2C+F%3BYeo%2C+L%3BHassan%2C+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2009-09-01&rft.volume=34&rft.issue=S1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.6626 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.6626/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-29 DO - http://dx.doi.org/10.1002/uog.6626 ER - TY - CPAPER T1 - Access to the Vision Literature Supporting International Collaborations: New Challenges, New Opportunities T2 - 10th International Congress on Medical Librarianship (ICML 2009) AN - 41929814; 5304310 JF - 10th International Congress on Medical Librarianship (ICML 2009) AU - Sieving, Pamela AU - Anton, Bette Y1 - 2009/08/31/ PY - 2009 DA - 2009 Aug 31 KW - Vision KW - International agreements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41929814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Congress+on+Medical+Librarianship+%28ICML+2009%29&rft.atitle=Access+to+the+Vision+Literature+Supporting+International+Collaborations%3A+New+Challenges%2C+New+Opportunities&rft.au=Sieving%2C+Pamela%3BAnton%2C+Bette&rft.aulast=Sieving&rft.aufirst=Pamela&rft.date=2009-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Congress+on+Medical+Librarianship+%28ICML+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icml2009.com/program/posters/posters1.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - agr and PSMs in CA-MRSA T2 - 2009 Gordon Research Conference on Staphylococcal Diseases AN - 42378251; 5378611 DE: JF - 2009 Gordon Research Conference on Staphylococcal Diseases AU - Otto, Michael Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42378251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Staphylococcal+Diseases&rft.atitle=agr+and+PSMs+in+CA-MRSA&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Staphylococcal+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=staph LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimization Based Geometric Modeling of Nano/Micro Scale Ion Milling of Organic Materials T2 - 2009 American Society of Mechanical Engineers International Design Engineering Technical Conferences (IDETC/CIE 2009) AN - 42308765; 5342809 DE: JF - 2009 American Society of Mechanical Engineers International Design Engineering Technical Conferences (IDETC/CIE 2009) AU - Fu, Jing AU - Joshi, Sanjay Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42308765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Society+of+Mechanical+Engineers+International+Design+Engineering+Technical+Conferences+%28IDETC%2FCIE+2009%29&rft.atitle=Optimization+Based+Geometric+Modeling+of+Nano%2FMicro+Scale+Ion+Milling+of+Organic+Materials&rft.au=Fu%2C+Jing%3BJoshi%2C+Sanjay&rft.aulast=Fu&rft.aufirst=Jing&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Society+of+Mechanical+Engineers+International+Design+Engineering+Technical+Conferences+%28IDETC%2FCIE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/IDETC09/ConferenceSchedule.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterizing DNA- and ATP-Induced Conformational Changes in a Domain of a Mismatch Repair Protein by Oxidative Surface Mapping and Mass Spectrometry T2 - 18th International Mass Spectrometry Conference AN - 41988579; 5328630 JF - 18th International Mass Spectrometry Conference AU - Tomer, Kenneth AU - Schorzman, A AU - Perera, L AU - Bebenek, K AU - Pedersen, L AU - Kunkel, T Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - Mass spectroscopy KW - Mapping KW - Mismatch repair KW - Peptide mapping KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41988579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+International+Mass+Spectrometry+Conference&rft.atitle=Characterizing+DNA-+and+ATP-Induced+Conformational+Changes+in+a+Domain+of+a+Mismatch+Repair+Protein+by+Oxidative+Surface+Mapping+and+Mass+Spectrometry&rft.au=Tomer%2C+Kenneth%3BSchorzman%2C+A%3BPerera%2C+L%3BBebenek%2C+K%3BPedersen%2C+L%3BKunkel%2C+T&rft.aulast=Tomer&rft.aufirst=Kenneth&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+International+Mass+Spectrometry+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.imsc-bremen-2009.de/TIS/index.php/general-information/confe rence-agenda LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glycosylation Profiling of Antibodies Isolated from Patients Diagnosed with the Autoimmune Muscle Diseases T2 - 18th International Mass Spectrometry Conference AN - 41974681; 5328747 JF - 18th International Mass Spectrometry Conference AU - Deterding, Leesa AU - Perdivara, I AU - Peddada, S AU - Miller, F AU - Tomer, K Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - Muscles KW - Antibodies KW - Glycosylation KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41974681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+International+Mass+Spectrometry+Conference&rft.atitle=Glycosylation+Profiling+of+Antibodies+Isolated+from+Patients+Diagnosed+with+the+Autoimmune+Muscle+Diseases&rft.au=Deterding%2C+Leesa%3BPerdivara%2C+I%3BPeddada%2C+S%3BMiller%2C+F%3BTomer%2C+K&rft.aulast=Deterding&rft.aufirst=Leesa&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+International+Mass+Spectrometry+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.imsc-bremen-2009.de/TIS/index.php/general-information/confe rence-agenda LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. AN - 67622481; 19716796 AB - The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic fibroblasts with constitutively increased DNA damage due to the absence of the full-length form of the tumor suppressor Brca1 (Brca1(Delta 11/Delta 11)), we show that deletion of p53 binding protein 1 (53BP1) selectivity abrogates senescence and cell death stimulated by reduced Brca1 activity. Furthermore, the embryonic lethality induced by Brca1 mutation can be alleviated by 53BP1 deletion. Adult Brca1(Delta 11/Delta 11)53BP1(-/-) manifest constitutively high levels of genomic instability, yet age relatively normally, with a surprisingly low incidence of overall tumor formation. Together, these in vitro and in vivo data suggest that 53BP1 is specifically required for the development of premature senescence and apoptosis induced by Brca1 deficiency. These observations may have important implications for Brca1-mediated tumor formation as well as for the molecular pathway leading from genomic instability to organismal aging. JF - Molecular cell AU - Cao, Liu AU - Xu, Xioaling AU - Bunting, Samuel F AU - Liu, Jie AU - Wang, Rui-Hong AU - Cao, Longyue L AU - Wu, J Julie AU - Peng, Tie-Nan AU - Chen, Junjie AU - Nussenzweig, Andre AU - Deng, Chu-Xia AU - Finkel, Toren AD - Translational Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. liu.cao@nih.gov Y1 - 2009/08/28/ PY - 2009 DA - 2009 Aug 28 SP - 534 EP - 541 VL - 35 IS - 4 KW - BRCA1 Protein KW - 0 KW - Cell Cycle Proteins KW - Chromosomal Proteins, Non-Histone KW - DNA-Binding Proteins KW - H2AX protein, mouse KW - Histones KW - Intracellular Signaling Peptides and Proteins KW - Trp53bp1 protein, mouse KW - Tumor Suppressor Proteins KW - Tumor Suppressor p53-Binding Protein 1 KW - Doxorubicin KW - 80168379AG KW - Hydrogen Peroxide KW - BBX060AN9V KW - Checkpoint Kinase 2 KW - EC 2.7.1.11 KW - Ataxia Telangiectasia Mutated Proteins KW - EC 2.7.11.1 KW - Atm protein, mouse KW - Chek2 protein, mouse KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Animals KW - Protein-Serine-Threonine Kinases -- metabolism KW - DNA-Binding Proteins -- genetics KW - Tumor Suppressor Proteins -- genetics KW - Doxorubicin -- toxicity KW - Mice, Knockout KW - Apoptosis -- genetics KW - Fibroblasts -- pathology KW - Cell Cycle Proteins -- genetics KW - Tumor Suppressor Proteins -- metabolism KW - Cell Transformation, Neoplastic -- genetics KW - DNA-Binding Proteins -- metabolism KW - Gamma Rays KW - Cell Transformation, Neoplastic -- metabolism KW - Mice KW - Protein-Serine-Threonine Kinases -- genetics KW - Fibroblasts -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Cells, Cultured KW - Histones -- metabolism KW - Histones -- genetics KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Genomic Instability -- radiation effects KW - BRCA1 Protein -- deficiency KW - Aging -- metabolism KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - BRCA1 Protein -- genetics KW - Genomic Instability -- drug effects KW - Cell Aging -- genetics KW - Aging -- genetics KW - Cell Aging -- radiation effects KW - Cell Aging -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67622481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=A+selective+requirement+for+53BP1+in+the+biological+response+to+genomic+instability+induced+by+Brca1+deficiency.&rft.au=Cao%2C+Liu%3BXu%2C+Xioaling%3BBunting%2C+Samuel+F%3BLiu%2C+Jie%3BWang%2C+Rui-Hong%3BCao%2C+Longyue+L%3BWu%2C+J+Julie%3BPeng%2C+Tie-Nan%3BChen%2C+Junjie%3BNussenzweig%2C+Andre%3BDeng%2C+Chu-Xia%3BFinkel%2C+Toren&rft.aulast=Cao&rft.aufirst=Liu&rft.date=2009-08-28&rft.volume=35&rft.issue=4&rft.spage=534&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=1097-4164&rft_id=info:doi/10.1016%2Fj.molcel.2009.06.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-10 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Mar 10;287(5459):1824-7 [10710310] J Exp Med. 2000 Jun 5;191(11):1819-28 [10839799] Nature. 2000 Nov 9;408(6809):248-54 [11089982] Nat Genet. 2001 Jul;28(3):266-71 [11431698] Oncogene. 2001 Nov 8;20(51):7514-23 [11709723] Science. 2002 May 3;296(5569):922-7 [11934988] EMBO J. 2002 Oct 1;21(19):5195-205 [12356735] Genes Dev. 2003 Jan 15;17(2):201-13 [12533509] Oncogene. 2003 Jan 30;22(4):528-37 [12555066] Mol Cell Biol. 2003 Apr;23(7):2556-63 [12640136] Nat Cell Biol. 2003 Aug;5(8):741-7 [12855956] Nature. 1992 Mar 19;356(6366):215-21 [1552940] Nature. 1993 Apr 29;362(6423):847-9 [8479522] Nature. 1993 Apr 29;362(6423):849-52 [8479523] Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7 [7568133] Cell. 1996 Jul 12;86(1):159-71 [8689683] Genes Dev. 1997 May 15;11(10):1226-41 [9171368] Nat Genet. 1997 Jul;16(3):298-302 [9207798] Nature. 2004 Nov 18;432(7015):406-11 [15525939] Cell. 2005 Feb 25;120(4):497-512 [15734682] Nature. 2005 Apr 14;434(7035):864-70 [15829956] Nature. 2005 Apr 14;434(7035):907-13 [15829965] Nature. 2005 Aug 4;436(7051):642 [16079833] Nature. 2005 Aug 4;436(7051):660-5 [16079837] Nature. 2005 Aug 4;436(7051):720-4 [16079850] Nature. 2005 Aug 4;436(7051):725-30 [16079851] EMBO J. 2006 May 17;25(10):2167-77 [16675955] Nature. 2006 Nov 30;444(7119):633-7 [17136093] Nature. 2006 Nov 30;444(7119):638-42 [17136094] Cell. 2006 Dec 29;127(7):1361-73 [17190600] Cell. 2007 Jul 13;130(1):63-75 [17599403] Nature. 2007 Aug 16;448(7155):767-74 [17700693] Nat Rev Mol Cell Biol. 2007 Sep;8(9):715-22 [17717516] Nucleic Acids Res. 2007;35(22):7417-28 [17913751] Nucleic Acids Res. 2007;35(22):7475-84 [17942417] Nat Rev Mol Cell Biol. 2008 May;9(5):402-12 [18431400] Trends Cell Biol. 2009 May;19(5):207-17 [19342239] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molcel.2009.06.037 ER - TY - JOUR T1 - Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. AN - 67593897; 19561357 AB - Reversible protein glutathionylation plays a key role in cellular regulation and cell signaling and protects protein thiols from hyperoxidation. Sulfiredoxin (Srx), an enzyme that catalyzes the reduction of Cys-sulfinic acid derivatives of 2-Cys peroxiredoxins (2-Cys Prxs), has been shown to catalyze the deglutathionylation of actin. We show that deglutathionylation of 2-Cys Prx, a family of peroxidases, is specifically catalyzed by Srx. Using the ubiquitously expressed member of 2-Cys Prx, Prx I, we revealed the following. (i) Among its four Cys residues, Cys(52), Cys(83), and Cys(173) can be glutathionylated in vitro. Deglutathionylation with Cys mutants showed that Cys(83) and Cys(173) were preferentially catalyzed by Srx, with glutathionylated Srx as the reaction intermediate, whereas glutaredoxin I was more favorable for deglutathionylating Cys(52). (ii) Studies using site-directed mutagenesis coupled with binding and deglutathionylation activities revealed that Pro(174) and Pro(179) of Prx I and Tyr(92) of Srx are essential for both activities. Furthermore, relative to glutaredoxin I, Srx exhibited negligible deglutathionylation activity for glutathionylated cysteine and glutathionylated BSA. These results indicate that Srx is specific for deglutathionylating Prx I due to its favorable affinity for Prx I. To assess the biological relevance of these observations, we showed that Prx I is glutathionylated in A549 and HeLa cells under modest levels of H(2)O(2). In addition, the level of glutathionylated Prx I was substantially elevated in small interfering RNA-mediated Srx-knocked down cells, whereas the reverse was observed in Srx-overexpressing cells. However, glutathionylation of Prx V, not known to bind to Srx, was not affected by the change in Srx expression levels. JF - The Journal of biological chemistry AU - Park, Ji Won AU - Mieyal, John J AU - Rhee, Sue Goo AU - Chock, P Boon AD - Laboratory of Biochemistry, Biochemistry and Biophysics Center, Division of Intramural Research, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-8012, USA. Y1 - 2009/08/28/ PY - 2009 DA - 2009 Aug 28 SP - 23364 EP - 23374 VL - 284 IS - 35 SN - 0021-9258, 0021-9258 KW - Glutaredoxins KW - 0 KW - Peroxiredoxins KW - EC 1.11.1.15 KW - Oxidoreductases Acting on Sulfur Group Donors KW - EC 1.8.- KW - SRXN1 protein, human KW - EC 1.8.98.2 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Kinetics KW - Humans KW - Protein Processing, Post-Translational KW - Glutaredoxins -- metabolism KW - Glutaredoxins -- genetics KW - Substrate Specificity KW - Cell Line KW - Biocatalysis KW - Peroxiredoxins -- chemistry KW - Oxidoreductases Acting on Sulfur Group Donors -- metabolism KW - Peroxiredoxins -- metabolism KW - Peroxiredoxins -- genetics KW - Oxidoreductases Acting on Sulfur Group Donors -- genetics KW - Glutathione -- metabolism KW - Oxidoreductases Acting on Sulfur Group Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67593897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Deglutathionylation+of+2-Cys+peroxiredoxin+is+specifically+catalyzed+by+sulfiredoxin.&rft.au=Park%2C+Ji+Won%3BMieyal%2C+John+J%3BRhee%2C+Sue+Goo%3BChock%2C+P+Boon&rft.aulast=Park&rft.aufirst=Ji&rft.date=2009-08-28&rft.volume=284&rft.issue=35&rft.spage=23364&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.021394 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12333-8 [10535922] Nature. 2008 Jan 3;451(7174):98-101 [18172504] Diabetes Res Clin Pract. 1999 Sep;45(2-3):101-12 [10588361] J Biol Chem. 2000 Aug 25;275(34):26556-65 [10854441] Biochemistry. 2000 Sep 12;39(36):11121-8 [10998251] Antioxid Redox Signal. 2000 Winter;2(4):811-20 [11213485] IUBMB Life. 2001 Jul;52(1-2):35-41 [11795591] J Biol Chem. 2002 Mar 22;277(12):9655-60 [11751890] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3505-10 [11904414] J Biol Chem. 2002 May 31;277(22):19396-401 [11904290] Biol Chem. 2002 Mar-Apr;383(3-4):347-64 [12033427] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9745-9 [12119401] J Biol Chem. 2002 Oct 11;277(41):38029-36 [12161445] Science. 2003 Apr 25;300(5619):653-6 [12714748] Proteomics. 2003 Jul;3(7):1154-61 [12872216] Nature. 2003 Oct 30;425(6961):980-4 [14586471] Biochem Biophys Res Commun. 1969 Nov 6;37(4):593-6 [5353890] Biochemistry. 1993 Apr 6;32(13):3368-76 [8461300] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7022-6 [8041739] J Biol Chem. 1994 Nov 4;269(44):27670-8 [7961686] Cell. 1995 Jan 27;80(2):225-36 [7834742] Science. 1995 Oct 13;270(5234):296-9 [7569979] J Chromatogr A. 1995 Sep 29;712(1):177-90 [8556150] J Biol Chem. 1997 Jan 3;272(1):217-21 [8995250] Methods Enzymol. 1999;300:219-26 [9919524] J Biol Chem. 2004 Dec 3;279(49):50994-1001 [15448164] Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):348-66 [15706083] Free Radic Res. 2005 Jun;39(6):573-80 [16036334] Biochemistry. 2005 Aug 9;44(31):10583-92 [16060667] Science. 2006 Jun 30;312(5782):1882-3 [16809515] Cancer Res. 2006 Jul 1;66(13):6800-6 [16818657] J Biol Chem. 2006 Oct 20;281(42):31736-42 [16916801] Biochemistry. 2006 Dec 26;45(51):15301-9 [17176052] J Biol Chem. 2007 Jul 27;282(30):22011-22 [17519234] Curr Opin Pharmacol. 2007 Aug;7(4):381-91 [17662654] J Biol Chem. 2008 Jan 4;283(1):284-93 [17974571] J Biol Chem. 1999 Dec 3;274(49):34543-6 [10574916] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.021394 ER - TY - JOUR T1 - Elements of danger--the case of medical imaging. AN - 67612863; 19710480 JF - The New England journal of medicine AU - Lauer, Michael S AD - National Heart, Lung, and Blood Institute, Bethesda, MD, USA. Y1 - 2009/08/27/ PY - 2009 DA - 2009 Aug 27 SP - 841 EP - 843 VL - 361 IS - 9 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Radiation Dosage KW - Humans KW - Tomography, X-Ray Computed -- trends KW - Magnetic Resonance Imaging -- utilization KW - Tomography, X-Ray Computed -- utilization KW - Medicare -- trends KW - Magnetic Resonance Imaging -- trends KW - Diagnostic Imaging -- utilization KW - Diagnostic Imaging -- adverse effects KW - Unnecessary Procedures -- adverse effects KW - Unnecessary Procedures -- economics KW - Diagnostic Imaging -- economics KW - Unnecessary Procedures -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67612863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Elements+of+danger--the+case+of+medical+imaging.&rft.au=Lauer%2C+Michael+S&rft.aulast=Lauer&rft.aufirst=Michael&rft.date=2009-08-27&rft.volume=361&rft.issue=9&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp0904735 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-02 N1 - Date created - 2009-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2009 Dec 3;361(23):2290; author reply 2291-2 [19967820] N Engl J Med. 2009 Dec 3;361(23):2291; author reply 2291-2 [19967792] N Engl J Med. 2009 Dec 3;361(23):2289; author reply 2291-2 [19955531] N Engl J Med. 2009 Dec 3;361(23):2289-90; author reply 2291-2 [19967819] Comment On: N Engl J Med. 2009 Aug 27;361(9):849-57 [19710483] Reprint In: Minn Med. 2009 Dec;92(12):40-1 [20092171] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMp0904735 ER - TY - JOUR T1 - Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. AN - 67611034; 19556424 AB - Infection of CD4(+) chemokine coreceptor(+) targets by HIV is aided and abetted by the proficiency of HIV in eliminating or neutralizing host cell-derived defensive molecules. Among these innate protective molecules, a family of intracellular apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases, is constitutively expressed but inactivated by HIV viral infectivity factor. The ability of interferon-alpha (IFN-alpha) to augment cytidine deaminases offered the possibility that the balance between virus and target cell might be altered in favor of the host. Further characterization of transcriptional profiles induced by IFN-alpha using microarrays, with the intention to identify and dissociate retroviral countermaneuvers from associated toxicities, revealed multiple molecules with suspected antiviral activity, including IL-27. To establish whether IFN-alpha toxicity might be sidestepped through the use of downstream IL-27 against HIV, we examined whether IL-27 directly regulated cytidine deaminases. Although IL-27 induces APOBECs, it does so in a delayed fashion. Dissecting the underlying regulatory events uncovered an initial IL-27-dependent induction of IFN-alpha and/or IFN-beta, which in turn, induces APOBEC3, inhibited by IFN-alpha/beta receptor blockade. In addition to macrophages, the IL-27-IFN-alpha connection is operative in CD4(+) T cells, consistent with an IFN-alpha-dependent pathway underlying host cell defense to HIV. JF - Blood AU - Greenwell-Wild, Teresa AU - Vázquez, Nancy AU - Jin, Wenwen AU - Rangel, Zoila AU - Munson, Peter J AU - Wahl, Sharon M AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4352, USA. Y1 - 2009/08/27/ PY - 2009 DA - 2009 Aug 27 SP - 1864 EP - 1874 VL - 114 IS - 9 KW - Cytokines KW - 0 KW - Interferon Type I KW - Interferon-alpha KW - Interleukin-17 KW - Lipopolysaccharides KW - Interferon-beta KW - 77238-31-4 KW - APOBEC3 protein, human KW - EC 3.5.4.1 KW - Cytosine Deaminase KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Abridged Index Medicus KW - Index Medicus KW - Cytidine Deaminase -- metabolism KW - Interferon-alpha -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Interferon-beta -- metabolism KW - Lipopolysaccharides -- metabolism KW - Humans KW - Leukocytes, Mononuclear -- metabolism KW - Cytosine Deaminase -- metabolism KW - Cytokines -- metabolism KW - Models, Biological KW - HIV-1 -- metabolism KW - CD4-Positive T-Lymphocytes -- cytology KW - Interleukin-17 -- metabolism KW - CD4-Positive T-Lymphocytes -- virology KW - Interferon Type I -- metabolism KW - Gene Expression Regulation KW - Interleukin-17 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67611034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Interleukin-27+inhibition+of+HIV-1+involves+an+intermediate+induction+of+type+I+interferon.&rft.au=Greenwell-Wild%2C+Teresa%3BV%C3%A1zquez%2C+Nancy%3BJin%2C+Wenwen%3BRangel%2C+Zoila%3BMunson%2C+Peter+J%3BWahl%2C+Sharon+M&rft.aulast=Greenwell-Wild&rft.aufirst=Teresa&rft.date=2009-08-27&rft.volume=114&rft.issue=9&rft.spage=1864&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2009-03-211540 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Immunol. 2008;26:317-53 [18304004] Blood. 2007 Jul 1;110(1):393-400 [17371941] Cell Host Microbe. 2008 Apr 17;3(4):245-52 [18342597] PLoS One. 2008;3(8):e2961 [18698365] Curr HIV Res. 2008 Sep;6(5):388-400 [18855649] Nat Rev Immunol. 2008 Nov;8(11):849-60 [18836477] Am J Pathol. 2009 Apr;174(4):1400-14 [19264901] AIDS Res Hum Retroviruses. 1997 Mar 1;13(4):283-90 [9071427] Science. 1997 Jun 20;276(5320):1857-61 [9188531] Ultrastruct Pathol. 1999 Mar-Apr;23(2):79-91 [10369102] J Exp Med. 2004 Nov 15;200(10):1337-46 [15545357] J Virol. 2005 Apr;79(7):4479-91 [15767448] J Gen Virol. 2005 Aug;86(Pt 8):2221-9 [16033969] J Exp Med. 2006 Jan 23;203(1):41-6 [16418394] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1440-5 [16434471] J Immunol. 2006 Apr 1;176(7):4252-7 [16547262] Blood. 2006 Jul 1;108(1):38-44 [16522819] J Virol. 2006 Aug;80(15):7645-57 [16840343] Nat Immunol. 2006 Sep;7(9):937-45 [16906166] J Immunol. 2006 Oct 15;177(8):5377-85 [17015723] J Leukoc Biol. 2006 Nov;80(5):973-83 [16908514] Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents [11585785] Immunity. 2002 Jun;16(6):779-90 [12121660] J Interferon Cytokine Res. 2003 Sep;23(9):513-22 [14565860] J Leukoc Biol. 2003 Nov;74(5):726-35 [12960226] J Immunol. 2004 Feb 15;172(4):2225-31 [14764690] J Immunol. 2004 Jul 15;173(2):715-20 [15240655] Science. 2004 Jul 30;305(5684):645 [15286366] J Immunol. 2004 Sep 15;173(6):3871-7 [15356135] J Exp Med. 2004 Sep 20;200(6):761-70 [15365095] J Exp Med. 2004 Sep 20;200(6):749-59 [15365096] J Virol. 1991 Nov;65(11):6362-4 [1920639] J Clin Invest. 1995 Jul;96(1):456-64 [7615818] Lancet. 2007 Jul 7;370(9581):81-8 [17617275] Curr Top Med Chem. 2007;7(13):1273-89 [17627557] J Mol Med (Berl). 2007 Jul;85(7):661-72 [17294231] AIDS. 2007 Sep 12;21(14):1855-65 [17721093] Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):483-90 [17706453] J Leukoc Biol. 2007 Nov;82(5):1185-92 [17684041] J Cell Biochem. 2007 Dec 1;102(5):1087-94 [17910035] Prog Neurobiol. 2007 Dec;83(5):310-31 [18023959] Eur J Immunol. 2007 Dec;37(12):3499-508 [17985330] AIDS. 2008 Jan 2;22(1):39-45 [18090390] Nature. 2008 Jan 24;451(7177):425-30 [18200009] J Leukoc Biol. 2006 Nov;80(5):961-4 [16935944] J Immunol. 2007 Feb 1;178(3):1671-9 [17237417] Blood. 2007 Mar 1;109(5):1841-9 [17068156] Clin Immunol. 2007 May;123(2):121-8 [17112786] J Immunol. 2007 Jun 15;178(12):7607-15 [17548596] PLoS Pathog. 2008 Feb;4(2):e1000007 [18389079] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2009-03-211540 ER - TY - JOUR T1 - High throughput evaluation of gamma-H2AX. AN - 67639314; 19703306 AB - The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical impact. Phosphorylation of histone H2AX to form gamma-H2AX is a known marker for irradiation-induced DNA DSBs. However, the first generation assay involves the use of immunofluorescent staining of gamma-H2AX foci. This assay is time consuming, operator dependent and is not scalable for high throughput assay development. Thus, we sought to develop a new assay using a high throughput electrochemiluminescent platform from Mesoscale Discovery Systems to quantify gamma-H2AX levels. The results show that our assay utilizes significantly less time and labor, has greater intra-assay reproducibility and has a greater dynamic range of gamma-H2AX versus irradiation dose. JF - Radiation oncology (London, England) AU - Avondoglio, Dane AU - Scott, Tamalee AU - Kil, Whoon Jong AU - Sproull, Mary AU - Tofilon, Philip J AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute, National Cancer Institute, Bethesda, Maryland, USA. avondogd@mail.nih.gov Y1 - 2009/08/24/ PY - 2009 DA - 2009 Aug 24 SP - 31 VL - 4 KW - H2AFX protein, human KW - 0 KW - Histones KW - Index Medicus KW - Animals KW - Phosphorylation -- radiation effects KW - Humans KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Dose-Response Relationship, Radiation KW - Fluorescent Antibody Technique KW - Luminescent Measurements KW - Histones -- radiation effects KW - DNA Breaks, Double-Stranded -- radiation effects KW - Electrochemical Techniques KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67639314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+oncology+%28London%2C+England%29&rft.atitle=High+throughput+evaluation+of+gamma-H2AX.&rft.au=Avondoglio%2C+Dane%3BScott%2C+Tamalee%3BKil%2C+Whoon+Jong%3BSproull%2C+Mary%3BTofilon%2C+Philip+J%3BCamphausen%2C+Kevin&rft.aulast=Avondoglio&rft.aufirst=Dane&rft.date=2009-08-24&rft.volume=4&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Radiation+oncology+%28London%2C+England%29&rft.issn=1748-717X&rft_id=info:doi/10.1186%2F1748-717X-4-31 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-27 N1 - Date created - 2009-09-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 2002 Oct;158(4):486-92 [12236816] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5057-62 [12679524] Mol Cell Biol. 2003 Aug;23(16):5706-15 [12897142] Radiat Res. 2003 Sep;160(3):309-17 [12926989] Int J Radiat Biol. 2003 May;79(5):351-8 [12943243] Clin Cancer Res. 2008 Feb 1;14(3):931-8 [18245557] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Cancer Res. 2005 Aug 1;65(15):6967-75 [16061682] Mol Cancer Ther. 2006 Jun;5(6):1504-10 [16818509] Assay Drug Dev Technol. 2007 Jun;5(3):391-401 [17638539] J Clin Oncol. 2007 Sep 10;25(26):4051-6 [17827453] Cancer Res. 2004 Jan 1;64(1):316-21 [14729640] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1748-717X-4-31 ER - TY - JOUR T1 - Radiation dose and breast cancer risk in the childhood cancer survivor study. AN - 67592461; 19620485 AB - The purpose of this study was to quantify the risk of breast cancer in relation to radiation dose and chemotherapy among survivors of childhood cancer. We conducted a case-control study of breast cancer in a cohort of 6,647 women who were 5-year survivors of childhood cancer and who were treated during 1970 through 1986. One hundred twenty patients with histologically confirmed breast cancer were identified and were individually matched to four selected controls on age at initial cancer and time since initial cancer. Medical physicists estimated radiation dose to the breast tumor site and ovaries on the basis of medical records. The odds ratio for breast cancer increased linearly with radiation dose, and it reached 11-fold for local breast doses of approximately 40 Gy relative to no radiation (P for trend < .0001). Risk associated with breast irradiation was sharply reduced among women who received 5 Gy or more to the ovaries (P = .002). The excess odds ratio per Gy was 0.36 for those who received ovarian doses less than 5 Gy and was 0.06 for those who received higher doses. Radiation-related risk did not vary significantly by age at exposure. Borderline significantly elevated risks were seen for doxorubicin, dactinomycin, dacarbazine, and carmustine. Results confirm the radiation sensitivity of the breast in girls age 10 to 20 years but do not demonstrate a strong effect of age at exposure within this range. Irradiation of the ovaries at doses greater than 5 Gy seems to lessen the carcinogenic effects of breast irradiation, most likely by reducing exposure of radiation-damaged breast cells to stimulating effects of ovarian hormones. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Inskip, Peter D AU - Robison, Leslie L AU - Stovall, Marilyn AU - Smith, Susan A AU - Hammond, Sue AU - Mertens, Ann C AU - Whitton, John A AU - Diller, Lisa AU - Kenney, Lisa AU - Donaldson, Sarah S AU - Meadows, Anna T AU - Neglia, Joseph P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7238, USA. inskippe@mail.nih.gov Y1 - 2009/08/20/ PY - 2009 DA - 2009 Aug 20 SP - 3901 EP - 3907 VL - 27 IS - 24 KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Dose-Response Relationship, Radiation KW - Survivors KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Breast Neoplasms -- etiology KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Radiation+dose+and+breast+cancer+risk+in+the+childhood+cancer+survivor+study.&rft.au=Inskip%2C+Peter+D%3BRobison%2C+Leslie+L%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BHammond%2C+Sue%3BMertens%2C+Ann+C%3BWhitton%2C+John+A%3BDiller%2C+Lisa%3BKenney%2C+Lisa%3BDonaldson%2C+Sarah+S%3BMeadows%2C+Anna+T%3BNeglia%2C+Joseph+P&rft.aulast=Inskip&rft.aufirst=Peter&rft.date=2009-08-20&rft.volume=27&rft.issue=24&rft.spage=3901&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.20.7738 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-03 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):1-8 [12182968] Blood. 2008 Jan 15;111(2):939-44 [17911386] J Natl Cancer Inst. 2003 Jul 2;95(13):971-80 [12837833] JAMA. 2003 Jul 23;290(4):465-75 [12876089] J Clin Oncol. 2000 Feb;18(3):487-97 [10653864] J Clin Oncol. 2000 Feb;18(3):498-509 [10653865] J Clin Oncol. 2000 Jun;18(12):2435-43 [10856104] J Natl Cancer Inst. 2001 Apr 18;93(8):618-29 [11309438] Med Pediatr Oncol. 2002 Apr;38(4):229-39 [11920786] J Clin Oncol. 2003 Dec 1;21(23):4386-94 [14645429] Ann Intern Med. 2004 Oct 19;141(8):590-7 [15492338] Comput Biomed Res. 1981 Apr;14(2):138-43 [7273715] J Natl Cancer Inst. 1987 Mar;78(3):459-64 [3469460] J Natl Cancer Inst. 1993 Jan 6;85(1):25-31 [8416252] N Engl J Med. 1996 Mar 21;334(12):745-51 [8592547] Cancer. 1997 Mar 15;79(6):1203-10 [9070499] Radiol Clin North Am. 1997 Nov;35(6):1265-80 [9374990] J Natl Cancer Inst Monogr. 2005;(34):25-7 [15784817] J Natl Cancer Inst. 2005 Oct 5;97(19):1428-37 [16204692] J Clin Endocrinol Metab. 2006 May;91(5):1723-8 [16492690] Radiat Res. 2006 Jul;166(1 Pt 2):141-57 [16808603] Pediatrics. 2002 Nov;110(5):911-9 [12415029] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.20.7738 ER - TY - JOUR T1 - Risk of Human Papillomavirus-Associated Cancers Among Persons With AIDS AN - 20831128; 10994672 AB - Background Although risk of human papillomavirus (HPV)-associated cancers of the anus, cervix, oropharynx, penis, vagina, and vulva is increased among persons with AIDS, the etiologic role of immunosuppression is unclear and incidence trends for these cancers over time, particularly after the introduction of highly active antiretroviral therapy in 1996, are not well described.Methods Data on 499 230 individuals diagnosed with AIDS from January 1, 1980, through December 31, 2004, were linked with cancer registries in 15 US regions. Risk of in situ and invasive HPV-associated cancers, compared with that in the general population, was measured by use of standardized incidence ratios (SIRs) and 95% confidence intervals (CIs). We evaluated the relationship of immunosuppression with incidence during the period of 4-60 months after AIDS onset by use of CD4 T-cell counts measured at AIDS onset. Incidence during the 4-60 months after AIDS onset was compared across three periods (1980-1989, 1990-1995, and 1996-2004). All statistical tests were two-sided.Results Among persons with AIDS, we observed statistically significantly elevated risk of all HPV-associated in situ (SIRs ranged from 8.9, 95% CI = 8.0 to 9.9, for cervical cancer to 68.6, 95% CI = 59.7 to 78.4, for anal cancer among men) and invasive (SIRs ranged from 1.6, 95% CI = 1.2 to 2.1, for oropharyngeal cancer to 34.6, 95% CI = 30.8 to 38.8, for anal cancer among men) cancers. During 1996-2004, low CD4 T-cell count was associated with statistically significantly increased risk of invasive anal cancer among men (relative risk [RR] per decline of 100 CD4 T cells per cubic millimeter = 1.34, 95% CI = 1.08 to 1.66, P = .006) and non-statistically significantly increased risk of in situ vagina or vulva cancer (RR = 1.52, 95% CI = 0.99 to 2.35, P = .055) and of invasive cervical cancer (RR = 1.32, 95% CI = 0.96 to 1.80, P = .077). Among men, incidence (per 100 000 person-years) of in situ and invasive anal cancer was statistically significantly higher during 1996-2004 than during 1990-1995 (61% increase for in situ cancers, 18.3 cases vs 29.5 cases, respectively; RR = 1.71, 95% CI = 1.24 to 2.35, P < .001; and 104% increase for invasive cancers, 20.7 cases vs 42.3 cases, respectively; RR = 2.03, 95% CI = 1.54 to 2.68, P < .001). Incidence of other cancers was stable over time.Conclusions Risk of HPV-associated cancers was elevated among persons with AIDS and increased with increasing immunosuppression. The increasing incidence for anal cancer during 1996-2004 indicates that prolonged survival may be associated with increased risk of certain HPV-associated cancers. JF - Journal of the National Cancer Institute AU - Chaturvedi, Anil K AU - Madeleine, Margaret M AU - Biggar, Robert J AU - Engels, Eric A Y1 - 2009/08/19/ PY - 2009 DA - 2009 Aug 19 SP - 1120 EP - 1130 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 16 SN - 0027-8874, 0027-8874 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts; Oncogenes & Growth Factors Abstracts KW - Risk assessment KW - Invasiveness KW - Acquired immune deficiency syndrome KW - Data processing KW - Oropharynx KW - Cervical cancer KW - Vulva KW - Statistical analysis KW - Survival KW - Penis KW - Cancer KW - oropharyngeal cancer KW - Anus KW - CD4 antigen KW - highly active antiretroviral therapy KW - antiretroviral agents KW - Vagina KW - Lymphocytes T KW - survival KW - Human papillomavirus KW - Immunosuppression KW - V 22360:AIDS and HIV KW - B 26650:Viral Oncogenes KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20831128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Risk+of+Human+Papillomavirus-Associated+Cancers+Among+Persons+With+AIDS&rft.au=Chaturvedi%2C+Anil+K%3BMadeleine%2C+Margaret+M%3BBiggar%2C+Robert+J%3BEngels%2C+Eric+A&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2009-08-19&rft.volume=101&rft.issue=16&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp205 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Acquired immune deficiency syndrome; Invasiveness; Oropharynx; Data processing; Cervical cancer; Statistical analysis; Vulva; Survival; Penis; oropharyngeal cancer; Anus; CD4 antigen; highly active antiretroviral therapy; Vagina; Lymphocytes T; Immunosuppression; antiretroviral agents; survival; Cancer; Human papillomavirus DO - http://dx.doi.org/10.1093/jnci/djp205 ER - TY - JOUR T1 - Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. AN - 67592165; 19687490 AB - Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. To compare the benefits and side effects of TwHF extract with those of sulfasalazine for the treatment of active rheumatoid arthritis. Randomized, controlled trial. A computer-generated code with random, permuted blocks was used to assign treatment. 2 U.S. academic centers (National Institutes of Health, Bethesda, Maryland, and University of Texas, Dallas, Texas) and 9 rheumatology subspecialty clinics (in Dallas and Austin, Texas; Tampa and Fort Lauderdale, Florida; Arlington, Virginia; Duncanville, Pennsylvania; Wheaton and Greenbelt, Maryland; and Lansing, Michigan). 121 patients with active rheumatoid arthritis and 6 or more painful and swollen joints. TwHF extract, 60 mg 3 times daily, or sulfasalazine, 1 g twice daily. Patients could continue stable doses of oral prednisone or nonsteroidal anti-inflammatory drugs but had to stop taking disease-modifying antirheumatic drugs at least 28 days before randomization. The primary outcome was the rate of achievement of 20% improvement in the American College of Rheumatology criteria (ACR 20) at 24 weeks. Secondary end points were safety; radiographic scores of joint damage; and serum levels of interleukin-6, cholesterol, cortisol, and adrenocorticotropic hormone. Outcome data were available for only 62 patients at 24 weeks. In a mixed-model analysis that imputed data for patients who dropped out, 65.0% (95% CI, 51.6% to 76.9%) of the TwHF group and 32.8% (CI, 21.3% to 46.0%) of the sulfasalazine group met the ACR 20 response criteria (P=0.001). Patients receiving TwHF also had significantly higher response rates for ACR 50 and ACR 70 in mixed-model analyses. Analyses of only completers showed similar significant differences between the treatment groups. Significant improvement was demonstrated in all individual components of the ACR response, including the Health Assessment Questionnaire disability score. Interleukin-6 levels rapidly and significantly decreased in the TwHF group. Although not statistically significant, radiographic progression was lower in the TwHF group. The frequency of adverse events was similar in both groups. Only 62% and 41% of patients continued receiving TwHF extract and sulfasalazine, respectively, during the 24 weeks of the study. Long-term outcome data were not collected on participants who discontinued treatment. In patients who continued treatment for 24 weeks and could also use stable oral prednisone and nonsteroidal anti-inflammatory drugs, attainment of the ACR 20 response criteria was significantly greater with TwHF extract than with sulfasalazine. JF - Annals of internal medicine AU - Goldbach-Mansky, Raphaela AU - Wilson, Mildred AU - Fleischmann, Roy AU - Olsen, Nancy AU - Silverfield, Joel AU - Kempf, Phillip AU - Kivitz, Alan AU - Sherrer, Yvonne AU - Pucino, Frank AU - Csako, Gyorgy AU - Costello, Rene AU - Pham, Tuyet Hang AU - Snyder, Christopher AU - van der Heijde, Désirée AU - Tao, Xuelian AU - Wesley, Robert AU - Lipsky, Peter E AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-0001, USA. goldbacr@mail.nih.gov Y1 - 2009/08/18/ PY - 2009 DA - 2009 Aug 18 SP - 229 EP - 40, W49-51 VL - 151 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antirheumatic Agents KW - Plant Extracts KW - Sulfasalazine KW - 3XC8GUZ6CB KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Patient Compliance KW - Prednisone -- therapeutic use KW - Humans KW - Adult KW - Gastrointestinal Diseases -- chemically induced KW - Aged KW - Middle Aged KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Plant Extracts -- therapeutic use KW - Antirheumatic Agents -- adverse effects KW - Sulfasalazine -- adverse effects KW - Tripterygium KW - Sulfasalazine -- therapeutic use KW - Plant Extracts -- adverse effects KW - Phytotherapy -- adverse effects KW - Antirheumatic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Comparison+of+Tripterygium+wilfordii+Hook+F+versus+sulfasalazine+in+the+treatment+of+rheumatoid+arthritis%3A+a+randomized+trial.&rft.au=Goldbach-Mansky%2C+Raphaela%3BWilson%2C+Mildred%3BFleischmann%2C+Roy%3BOlsen%2C+Nancy%3BSilverfield%2C+Joel%3BKempf%2C+Phillip%3BKivitz%2C+Alan%3BSherrer%2C+Yvonne%3BPucino%2C+Frank%3BCsako%2C+Gyorgy%3BCostello%2C+Rene%3BPham%2C+Tuyet+Hang%3BSnyder%2C+Christopher%3Bvan+der+Heijde%2C+D%C3%A9sir%C3%A9e%3BTao%2C+Xuelian%3BWesley%2C+Robert%3BLipsky%2C+Peter+E&rft.aulast=Goldbach-Mansky&rft.aufirst=Raphaela&rft.date=2009-08-18&rft.volume=151&rft.issue=4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arthritis Rheum. 2000 Aug;43(8):1809-19 [10943871] Cochrane Database Syst Rev. 2000;(2):CD000958 [10796400] J Tradit Chin Med. 2001 Mar;21(1):50-1 [11360541] Se Pu. 1998 Jul;16(4):356-7 [11367766] Acta Pharmacol Sin. 2000 Sep;21(9):782-6 [11501157] Arthritis Rheum. 2001 Sep;44(9):1984-92 [11592358] J Rheumatol. 2001 Oct;28(10):2160-7 [11669150] Arthritis Rheum. 2002 Jul;46(7):1735-43 [12124856] Contraception. 2002 Jun;65(6):441-5 [12127645] Drugs R D. 2003;4(1):1-18 [12568630] Nature. 2003 May 15;423(6937):356-61 [12748655] N Engl J Med. 2004 Jun 17;350(25):2591-602 [15201416] Arthritis Rheum. 2004 Sep;50(9):2995-303 [15457469] J Am Chem Soc. 1972 Oct 4;94(20):7194-5 [5072337] Lancet. 1987 May 16;1(8542):1108-11 [2883443] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1987 Oct;9(5):317-22 [2968853] Zhonghua Xin Xue Guan Bing Za Zhi. 1989 Aug;17(4):236-7 [2627881] Arch Intern Med. 1993 Jun 14;153(11):1337-42 [8507124] J Pharmacol Exp Ther. 1995 Mar;272(3):1305-12 [7891348] Arthritis Rheum. 1995 Jun;38(6):727-35 [7779114] Arthritis Rheum. 1998 Jan;41(1):130-8 [9433878] Lancet. 1999 Jan 23;353(9149):259-66 [9929017] J Biol Chem. 1999 May 7;274(19):13443-50 [10224109] J Biol Chem. 1999 May 7;274(19):13451-5 [10224110] Transplant Proc. 1999 Aug;31(5):2056-7 [10455969] Am J Chin Med. 2005;33(6):945-55 [16355451] Arthritis Rheum. 2006 Apr;54(4):1063-74 [16572441] Ann Intern Med. 2006 Jun 20;144(12):865-76 [16785475] Transplant Proc. 2006 Jun;38(5):1274-9 [16797280] Ann N Y Acad Sci. 2006 Jun;1069:414-9 [16855168] Arthritis Rheum. 2006 Sep;54(9):2793-806 [16947627] Biomed Pharmacother. 2006 Dec;60(10):688-92 [17049202] Phytochemistry. 2007 Mar;68(6):732-66 [17250858] Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94 [17360534] Dig Dis Sci. 2007 Aug;52(8):1790-7 [17410440] Ann Rheum Dis. 2007 Sep;66(9):1162-7 [17485422] Lancet. 2007 Dec 1;370(9602):1861-74 [17570481] Ann Intern Med. 2008 Jan 15;148(2):124-34 [18025440] Rheumatology (Oxford). 2000 Sep;39(9):975-81 [10986302] J Rheumatol. 2000 Jan;27(1):261-3 [10648051] Rheum Dis Clin North Am. 2000 Feb;26(1):29-50, viii [10680192] Arthritis Rheum. 2000 Mar;43(3):495-505 [10728741] Summary For Patients In: Ann Intern Med. 2009 Aug 18;151(4):I-36 [19687475] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women AN - 745642437; 13163044 AB - Estrogen and its metabolites are believed to play important roles in breast cancer, and its determinants include both genetic and lifestyle factors. The objective of the study is to investigate the association of breast cancer risk in Thailand with genetic polymorphisms in several genes involved in estrogen synthesis and metabolism. Five hundred and seventy patients with histopathologically confirmed breast cancer and 497 controls were included in the present study. Forty single nucleotide polymorphisms (SNPs) in the CYP1A1, CYP1A2, CYP1B1, CYP17, CYP19, CYP2C9, CYP2C19, AhR, ESR1, PGR, ERRG, COMT, HSD17B1, HSD17B2, EPHX1 and NQO1 genes were genotyped. Association of genotypes with breast cancer risk was evaluated using multivariate logistic regression, which suggested an altered risk for the following SNPs [gene, odds ratio (OR) and 95% confidence interval are shown]: heterozygote carriers of rs4917623 [CYP2C19, OR = 1.38 (1.04-1.84)], rs2066853 [AhR, OR = 1.34 (1.02-1.76)] and rs1857407 [ERRG, (OR = 0.72 (0.55-0.96)]; homozygote carriers of rs762551 [CYP1A2, OR = 2.75 (1.47-5.14)], rs4917623 [CYP2C19, OR = 1.48 (1.00-2.19) and rs945453 [ERRG, OR = 1.66 (1.04-2.65)]. In addition, a stratified analysis by menopausal status indicated that the association of the CYP1A2 (rs762551) and CYP17 (rs743572) polymorphisms with breast cancer risk were mainly evident in premenopausal, while ERRG (rs1857407) was significant in postmenopausal women. These findings suggest that CYP1A2, CYP2C19, AhR, ERRG and CYP17 polymorphisms may play an important role in estrogen metabolism and modify individual susceptibility to breast cancer in Thai women. JF - International Journal of Cancer AU - Sangrajrang, Suleeporn AU - Sato, Yasunori AU - Sakamoto, Hiromi AU - Ohnami, Sumiko AU - Laird, Nan M AU - Khuhaprema, Thiravud AU - Brennan, Paul AU - Boffetta, Paolo AU - Yoshida, Teruhiko AD - Research Division, National Cancer Institute, Ratchathewi, Bangkok, Thailand, tyoshida@ncc.go.jp Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 837 EP - 843 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 4 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts; Risk Abstracts KW - Thailand KW - Gene polymorphism KW - Metabolites KW - Genotypes KW - Homozygotes KW - Aromatase KW - Post-menopause KW - Estrogens KW - CYP1A2 protein KW - post-menopause KW - Enzymes KW - Cancer KW - Single-nucleotide polymorphism KW - Heterozygotes KW - Breast cancer KW - NAD(P)H dehydrogenase (quinone) KW - Females KW - Cytochrome P450 KW - Estrogen receptors KW - Metabolism KW - estrogens KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Genetic+polymorphisms+of+estrogen+metabolizing+enzyme+and+breast+cancer+risk+in+Thai+women&rft.au=Sangrajrang%2C+Suleeporn%3BSato%2C+Yasunori%3BSakamoto%2C+Hiromi%3BOhnami%2C+Sumiko%3BLaird%2C+Nan+M%3BKhuhaprema%2C+Thiravud%3BBrennan%2C+Paul%3BBoffetta%2C+Paolo%3BYoshida%2C+Teruhiko&rft.aulast=Sangrajrang&rft.aufirst=Suleeporn&rft.date=2009-08-15&rft.volume=125&rft.issue=4&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24434 L2 - http://www3.interscience.wiley.com/journal/122267066/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Estrogens; CYP1A2 protein; Gene polymorphism; Enzymes; Metabolites; Homozygotes; Aromatase; Single-nucleotide polymorphism; Post-menopause; Heterozygotes; Breast cancer; NAD(P)H dehydrogenase (quinone); Cytochrome P450; Estrogen receptors; post-menopause; Genotypes; Females; Metabolism; Cancer; estrogens; Thailand DO - http://dx.doi.org/10.1002/ijc.24434 ER - TY - JOUR T1 - The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism. AN - 742782150; pmid-19425057 AB - A body of work has emerged over the past decade demonstrating a relationship between mutations in glucocerebrosidase gene (GBA), the gene implicated in Gaucher disease (GD), and the development of parkinsonism. Several different lines of research support this relationship. First, patients with GD who are homozygous for mutations in GBA have a higher than expected propensity to develop Parkinson's disease (PD). Furthermore, carriers of GBA mutations, particularly family members of patients with GD, have displayed an increased rate of parkinsonism. Subsequently, investigators from centers around the world screened cohorts of patients with parkinsonism for GBA mutations and found that overall, subjects with PD, as well as other Lewy body disorders, have at least a fivefold increase in the number of carriers of GBA mutations as compared to age-matched controls. In addition, neuropathologic studies of subjects with parkinsonism carrying GBA mutations demonstrate Lewy bodies, depletion of neurons of the substantia nigra, and involvement of hippocampal layers CA2-4. Although the basis for this association has yet to be elucidated, evidence continues to support the role of GBA as a PD risk factor across different centers, synucleinopathies, and ethnicities. Further studies of the association between GD and parkinsonism will stimulate new insights into the pathophysiology of the two disorders and will prove crucial for both genetic counseling of patients and family members and the design of relevant therapeutic strategies for specific patients with parkinsonism. 2009 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - DePaolo, John AU - Goker-Alpan, Ozlem AU - Samaddar, Ted AU - Lopez, Grisel AU - Sidransky, Ellen AD - Section on Molecular Neurogenetics, Medical Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland 20892-3708, USA. Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 1571 EP - 1578 VL - 24 IS - 11 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Enzyme Replacement Therapy KW - Aged KW - Child KW - Genetic Counseling KW - alpha-Synuclein -- genetics KW - Parkinsonian Disorders -- epidemiology KW - Gaucher Disease -- genetics KW - Adult KW - Gaucher Disease -- drug therapy KW - Lewy Body Disease -- epidemiology KW - Lysosomes -- enzymology KW - Genetic Predisposition to Disease KW - Male KW - Ethnic Groups -- genetics KW - Parkinsonian Disorders -- genetics KW - alpha-Synuclein -- metabolism KW - DNA Mutational Analysis KW - Gaucher Disease -- pathology KW - Parkinsonian Disorders -- enzymology KW - Parkinsonian Disorders -- pathology KW - Lewy Body Disease -- genetics KW - Substantia Nigra -- pathology KW - Risk Factors KW - Middle Aged KW - Hippocampus -- pathology KW - Female KW - Gaucher Disease -- epidemiology KW - Glucosylceramidase -- therapeutic use KW - Glucosylceramidase -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=The+association+between+mutations+in+the+lysosomal+protein+glucocerebrosidase+and+parkinsonism.&rft.au=DePaolo%2C+John%3BGoker-Alpan%2C+Ozlem%3BSamaddar%2C+Ted%3BLopez%2C+Grisel%3BSidransky%2C+Ellen&rft.aulast=DePaolo&rft.aufirst=John&rft.date=2009-08-15&rft.volume=24&rft.issue=11&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. AN - 733965959; 19671873 AB - To conduct a phase I trial of recombinant immunotoxin SS1P given by continuous infusion in chemoresistant solid tumors expressing mesothelin. Eligible patients had mesothelioma, ovarian, or pancreatic cancer, which was recurrent or unresectable despite standard therapy, and were mesothelin positive by immunohistochemistry. SS1P was given by continuous infusion for 10 days, and cycles could be repeated at 4-week intervals in the absence of neutralizing antibodies or progressive disease. Twenty-four patients, five with peritoneal mesothelioma, nine with pleural mesothelioma, two with pleural-peritoneal mesothelioma, seven with ovarian carcinoma, and one with pancreatic carcinoma, received 4, 8, 12, 18, and 25 microg/kg/d x10. The maximum tolerated dose was 25 microg/kg/d x10, where one of six patients had dose-limiting toxicity due to reversible vascular leak syndrome. Immunogenicity was observed in 18 (75%) of 24 patients, and five (21%) received a second cycle. Constant plasma levels of SS1P were maintained for most of the 10-day infusion time, with median peak levels of up to 153 ng/mL. One patient had a partial response. Nonmajor responses included cessation of ascites and independence from paracentesis, resolution of masses by positron emission tomography, and improved pain and range of motion. As a single agent by continuous infusion, recombinant immunotoxin SS1P was well tolerated up to 25 microg/kg/d x10 and showed evidence of modest clinical activity. Continuous infusion showed no significant advantage over bolus dosing, and further clinical development of SS1P is proceeding by bolus dosing in combination with chemotherapy. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kreitman, Robert J AU - Hassan, Raffit AU - Fitzgerald, David J AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. kreitmar@mail.nih.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 5274 EP - 5279 VL - 15 IS - 16 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - GPI-Linked Proteins KW - Membrane Glycoproteins KW - SS1(dsFv)PE38 KW - mesothelin KW - Index Medicus KW - Drug Administration Schedule KW - Antineoplastic Agents -- administration & dosage KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Peritoneal Neoplasms -- immunology KW - Humans KW - Aged KW - Peritoneal Neoplasms -- drug therapy KW - Mesothelioma -- immunology KW - Antineoplastic Agents -- adverse effects KW - Mesothelioma -- drug therapy KW - Adult KW - Pleural Neoplasms -- drug therapy KW - Middle Aged KW - Maximum Tolerated Dose KW - Membrane Glycoproteins -- immunology KW - Female KW - Male KW - Pleural Neoplasms -- immunology KW - Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- adverse effects KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733965959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+trial+of+continuous+infusion+anti-mesothelin+recombinant+immunotoxin+SS1P.&rft.au=Kreitman%2C+Robert+J%3BHassan%2C+Raffit%3BFitzgerald%2C+David+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-08-15&rft.volume=15&rft.issue=16&rft.spage=5274&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-29 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1995 Jul 28;62(3):351-5 [7628878] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Blood. 1996 Aug 15;88(4):1188-97 [8695836] Mol Immunol. 1997 Jan;34(1):9-20 [9182872] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):669-74 [9435250] Br J Haematol. 1998 Jul;102(2):509-15 [9695966] J Mol Biol. 1998 Sep 4;281(5):917-28 [9719644] Int J Cancer. 1999 Feb 9;80(4):559-63 [9935157] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Nat Biotechnol. 1999 Jun;17(6):568-72 [10385321] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Clin Cancer Res. 2006 Aug 1;12(15):4695-701 [16899620] Mol Cancer. 2006;5(1):50 [17067392] Annu Rev Med. 2007;58:221-37 [17059365] Pathol Int. 2007 Apr;57(4):190-9 [17316414] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17099-104 [17940013] Clin Cancer Res. 2007 Dec 1;13(23):7166-71 [18056197] Curr Med Chem. 2008;15(9):855-67 [18473795] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] J Immunother. 2000 Jul-Aug;23(4):473-9 [10916757] Cancer Res. 2001 Jul 1;61(13):5070-7 [11431343] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Clin Cancer Res. 2001 Dec;7(12):3862-8 [11751476] Cancer Res. 2002 Feb 1;62(3):819-26 [11830538] Clin Cancer Res. 2002 Nov;8(11):3520-6 [12429643] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3937-42 [15217923] Anticancer Res. 2004 May-Jun;24(3a):1327-35 [15274292] Cancer Res. 1989 Oct 15;49(20):5656-63 [2790783] Cancer Res. 1990 Nov 15;50(22):7382-92 [2224866] Int J Cancer. 1992 Feb 1;50(3):373-81 [1735605] Am J Surg Pathol. 1992 Mar;16(3):259-68 [1599018] Int J Cancer. 1992 Jun 19;51(4):548-54 [1351045] J Clin Oncol. 1993 Apr;11(4):726-37 [7683045] Cancer Res. 1993 May 1;53(9):2092-9 [8481911] Biochemistry. 1994 May 10;33(18):5451-9 [7910034] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0062 ER - TY - JOUR T1 - Treatments for nicotine addiction should be a top priority. AN - 67585884; 19394686 JF - Lancet (London, England) AU - Pollock, Jonathan D AU - Koustova, Elena AU - Hoffman, Allison AU - Shurtleff, David AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. jpollock@mail.nih.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 513 EP - 514 VL - 374 IS - 9689 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Smoking Cessation KW - Healthy People Programs KW - United States -- epidemiology KW - Cause of Death KW - Research Support as Topic KW - Health Services Needs and Demand KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- complications KW - Health Priorities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67585884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Treatments+for+nicotine+addiction+should+be+a+top+priority.&rft.au=Pollock%2C+Jonathan+D%3BKoustova%2C+Elena%3BHoffman%2C+Allison%3BShurtleff%2C+David%3BVolkow%2C+Nora+D&rft.aulast=Pollock&rft.aufirst=Jonathan&rft.date=2009-08-15&rft.volume=374&rft.issue=9689&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/10.1016%2FS0140-6736%2809%2960352-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Jun 14;283(22):2975-8 [10865276] Am J Prev Med. 2008 Feb;34(2):102-11 [18201639] MMWR Morb Mortal Wkly Rep. 2005 Jul 1;54(25):625-8 [15988406] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0140-6736(09)60352-4 ER - TY - JOUR T1 - Proline oxidase functions as a mitochondrial tumor suppressor in human cancers. AN - 67580925; 19654292 AB - Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves as the main source of energy, proline, an alternative substrate, is important, especially during nutrient stress. Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death. In a mouse xenograft tumor model, we found that POX greatly reduced tumor formation by causing G2 cell cycle arrest. Furthermore, immunohistochemical staining showed decreased POX expression in tumor tissues. Importantly, HIF-1alpha signaling was impaired with POX expression due to the increased production of alpha-ketoglutarate, a critical substrate for prolyl hydroxylation and degradation of HIF-1alpha. Combined with previous in vitro findings and reported clinical genetic associations, these new findings lead us to propose POX as a mitochondrial tumor suppressor and a potential target for cancer therapy. JF - Cancer research AU - Liu, Yongmin AU - Borchert, Gregory L AU - Donald, Steven P AU - Diwan, Bhalchandra A AU - Anver, Miriam AU - Phang, James M AD - Basic Science Program and Pathology/Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., and Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA. Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 6414 EP - 6422 VL - 69 IS - 16 KW - Antibiotics, Antineoplastic KW - 0 KW - Tumor Suppressor Proteins KW - Doxorubicin KW - 80168379AG KW - Proline Oxidase KW - EC 1.5.3.- KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Mice, Nude KW - Mice KW - Mice, Inbred BALB C KW - Antibiotics, Antineoplastic -- therapeutic use KW - Apoptosis -- genetics KW - Tumor Cells, Cultured KW - Doxorubicin -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Apoptosis -- drug effects KW - Xenograft Model Antitumor Assays KW - Doxorubicin -- therapeutic use KW - Mitochondria -- physiology KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - Tumor Suppressor Proteins -- physiology KW - Mitochondria -- enzymology KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Proline Oxidase -- metabolism KW - Mitochondria -- metabolism KW - Proline Oxidase -- physiology KW - Proline Oxidase -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67580925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Proline+oxidase+functions+as+a+mitochondrial+tumor+suppressor+in+human+cancers.&rft.au=Liu%2C+Yongmin%3BBorchert%2C+Gregory+L%3BDonald%2C+Steven+P%3BDiwan%2C+Bhalchandra+A%3BAnver%2C+Miriam%3BPhang%2C+James+M&rft.aulast=Liu&rft.aufirst=Yongmin&rft.date=2009-08-15&rft.volume=69&rft.issue=16&rft.spage=6414&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-1223 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-1223 ER - TY - JOUR T1 - Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids. AN - 67540175; 19615902 AB - The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent. JF - Bioorganic & medicinal chemistry letters AU - Kumar, Vineet AU - Malhotra, Sanjay V AD - Laboratory of Synthetic Chemistry, SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 4643 EP - 4646 VL - 19 IS - 16 KW - Antineoplastic Agents KW - 0 KW - Ionic Liquids KW - Organophosphorus Compounds KW - Quaternary Ammonium Compounds KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Humans KW - Cell Line, Tumor KW - Structure-Activity Relationship KW - Ionic Liquids -- toxicity KW - Ionic Liquids -- pharmacology KW - Quaternary Ammonium Compounds -- toxicity KW - Ionic Liquids -- chemistry KW - Antineoplastic Agents -- toxicity KW - Organophosphorus Compounds -- toxicity KW - Organophosphorus Compounds -- pharmacology KW - Organophosphorus Compounds -- chemistry KW - Quaternary Ammonium Compounds -- pharmacology KW - Quaternary Ammonium Compounds -- chemistry KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67540175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Study+on+the+potential+anti-cancer+activity+of+phosphonium+and+ammonium-based+ionic+liquids.&rft.au=Kumar%2C+Vineet%3BMalhotra%2C+Sanjay+V&rft.aulast=Kumar&rft.aufirst=Vineet&rft.date=2009-08-15&rft.volume=19&rft.issue=16&rft.spage=4643&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=1464-3405&rft_id=info:doi/10.1016%2Fj.bmcl.2009.06.086 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmcl.2009.06.086 ER - TY - JOUR T1 - Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium AN - 20773331; 10835211 AB - Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR)=1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (.30 cigarettes/day: OR=1.75, 95% CI: 1.27, 2.42), duration (.50 years: OR=2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (.40 pack-years: OR=1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis. JF - American Journal of Epidemiology AU - Lynch, Shannon M AU - Vrieling, Alina AU - Lubin, Jay H AU - Kraft, Peter AU - Mendelsohn, Julie B AU - Hartge, Patricia AU - Canzian, Federico AU - Steplowski, Emily AU - Arslan, Alan A AU - Gross, Myron AU - Helzlsouer, Kathy AU - Jacobs, Eric J AU - LaCroix, Andrea AU - Petersen, Gloria AU - Zheng, Wei AU - Albanes, Demetrius AU - Amundadottir, Laufey AU - Bingham, Sheila A AU - Boffetta, Paolo AU - Boutron-Ruault, Marie-Christine AU - Chanock, Stephen J AU - Clipp, Sandra AU - Hoover, Robert N AU - Jacobs, Kevin AU - Johnson, Karen C AU - Kooperberg, Charles AU - Luo, Juhua AU - Messina, Catherine AU - Palli, Domenico AU - Patel, Alpa V AU - Riboli, Elio AU - Shu, Xiao-Ou AU - Rodriguez Suarez, Laudina AU - Thomas, Gilles AU - Tjoenneland, Anne AU - Tobias, Geoffrey S AU - Tong, Elissa AU - Trichopoulos, Dimitrios AU - Virtamo, Jarmo AU - Ye, Weimin AU - Yu, Kai AU - Zeleniuch-Jacquette, Anne AU - Bueno-de-Mesquita, HBas AU - Stolzenberg-Solomon, Rachael Z Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 403 EP - 413 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 170 IS - 4 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Smoking KW - pancreatic cancer KW - Data processing KW - Risk factors KW - Carcinogenesis KW - Cigarette smoking KW - Pancreatic cancer KW - Drug addiction KW - Models KW - X 24380:Social Poisons & Drug Abuse KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Cigarette+Smoking+and+Pancreatic+Cancer%3A+A+Pooled+Analysis+From+the+Pancreatic+Cancer+Cohort+Consortium&rft.au=Lynch%2C+Shannon+M%3BVrieling%2C+Alina%3BLubin%2C+Jay+H%3BKraft%2C+Peter%3BMendelsohn%2C+Julie+B%3BHartge%2C+Patricia%3BCanzian%2C+Federico%3BSteplowski%2C+Emily%3BArslan%2C+Alan+A%3BGross%2C+Myron%3BHelzlsouer%2C+Kathy%3BJacobs%2C+Eric+J%3BLaCroix%2C+Andrea%3BPetersen%2C+Gloria%3BZheng%2C+Wei%3BAlbanes%2C+Demetrius%3BAmundadottir%2C+Laufey%3BBingham%2C+Sheila+A%3BBoffetta%2C+Paolo%3BBoutron-Ruault%2C+Marie-Christine%3BChanock%2C+Stephen+J%3BClipp%2C+Sandra%3BHoover%2C+Robert+N%3BJacobs%2C+Kevin%3BJohnson%2C+Karen+C%3BKooperberg%2C+Charles%3BLuo%2C+Juhua%3BMessina%2C+Catherine%3BPalli%2C+Domenico%3BPatel%2C+Alpa+V%3BRiboli%2C+Elio%3BShu%2C+Xiao-Ou%3BRodriguez+Suarez%2C+Laudina%3BThomas%2C+Gilles%3BTjoenneland%2C+Anne%3BTobias%2C+Geoffrey+S%3BTong%2C+Elissa%3BTrichopoulos%2C+Dimitrios%3BVirtamo%2C+Jarmo%3BYe%2C+Weimin%3BYu%2C+Kai%3BZeleniuch-Jacquette%2C+Anne%3BBueno-de-Mesquita%2C+HBas%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Lynch&rft.aufirst=Shannon&rft.date=2009-08-15&rft.volume=170&rft.issue=4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp134 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Smoking; Data processing; Risk factors; Cigarette smoking; Carcinogenesis; Pancreatic cancer; Drug addiction; Models; pancreatic cancer DO - http://dx.doi.org/10.1093/aje/kwp134 ER - TY - JOUR T1 - Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoite surface protein-6 and other Msp genes of Plasmodium falciparum AN - 20679992; 9450975 AB - Immune evasion by Plasmodium falciparum is favored by extensive allelic diversity of surface antigens. Some of them, most notably the vaccine-candidate merozoite surface protein (MSP)-1, exhibit a poorly understood pattern of allelic dimorphism, in which all observed alleles group into two highly diverged allelic families with few or no inter-family recombinants. Here we describe contrasting levels and patterns of sequence diversity in genes encoding three MSP-1-associated surface antigens of P. falciparum, ranging from an ancient allelic dimorphism in the Msp-6 gene to a near lack of allelic divergence in Msp-9 to a more classical multi-allele polymorphism in Msp-7. Other members of the Msp-7 gene family exhibit very little polymorphism in non-repetitive regions. A comparison of P. falciparum Msp-6 sequences to an orthologous sequence from P. reichenowi provided evidence for distinct evolutionary histories of the 5' and 3' segments of the dimorphic region in PfMsp-6, consistent with one dimorphic lineage having arisen from recombination between now-extinct ancestral alleles. In addition, we uncovered two surprising patterns of evolution in repetitive sequence. First, in Msp-6, large deletions are associated with (nearly) identical sequence motifs at their borders. Second, a comparison of PfMsp-9 with the P. reichenowi ortholog indicated retention of a significant inter-unit diversity within an 18-base pair repeat within the coding region of P. falciparum, but homogenization in P. reichenowi. nonsynonymous site synonymous site pairs of sequences JF - Gene AU - Roy, S W AU - Weedall, G D AU - da Silva, RL AU - Polley, S D AU - Ferreira, MU AD - National Library of Medicine, National Institutes of Health, Building 38A, Bethesda, MD 20894, USA, royscott@ncbi.nlm.nih.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 12 EP - 21 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 443 IS - 1-2 SN - 0378-1119, 0378-1119 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Phylogeny KW - Parasites KW - Allelles KW - Gene polymorphism KW - Genetic diversity KW - Plasmodium falciparum KW - Recombinants KW - Recombination KW - Antigens KW - Genes KW - surface antigens KW - MSP-6 gene KW - DNA KW - Merozoites KW - Evolution KW - Dimorphism KW - F 06905:Vaccines KW - Q1 08587:Diseases of Cultured Organisms KW - Q5 08501:General KW - G 07730:Development & Cell Cycle KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20679992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Sequence+diversity+and+evolutionary+dynamics+of+the+dimorphic+antigen+merozoite+surface+protein-6+and+other+Msp+genes+of+Plasmodium+falciparum&rft.au=Roy%2C+S+W%3BWeedall%2C+G+D%3Bda+Silva%2C+RL%3BPolley%2C+S+D%3BFerreira%2C+MU&rft.aulast=Roy&rft.aufirst=S&rft.date=2009-08-15&rft.volume=443&rft.issue=1-2&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2009.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Recombinants; Phylogeny; Recombination; Parasites; Genes; Antigens; Allelles; DNA; Genetic diversity; surface antigens; Gene polymorphism; MSP-6 gene; Merozoites; Evolution; Dimorphism; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.gene.2009.05.007 ER - TY - JOUR T1 - Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8 super(+) T cells independent of IFN-g and CD107a responses AN - 20178216; 10257346 AB - CD8 super(+) T lymphocytes (CTL) play a role in controlling HIV/SIV infection. CTL antiviral activity is dependent on recognition of antigenic peptides associated with MHC class I molecules on infected target cells, and CTL activation can be impaired by Nef-mediated down-regulation of MHC class I molecules. We tested the ability of a series of rhesus macaque CD8 super(+) T-cell clones specific for the SIV Gag CM9 peptide to suppress SIV infection of autologous CD4 super(+) T cells. We used a set of SIV sub(m) sub(a) sub(c)239 viruses with either wild-type Nef or Nef mutations that impair MHC class I down-regulation. All CTL clones efficiently suppressed virus replication in cells infected with mutant viruses with altered Nef function, phenotypically MHC class I super(h) super(i) super(g) super(h) or MHC class I super(i) super(n) super(t) super(e) super(r) super(m) super(e) super(d) super(i) super(a) super(t) super(e). However, the ability of the clones to suppress virus replication was variably reduced in the presence of wild-type Nef (MHC class I super(l) super(o) super(w)) despite the observations that all CTL clones showed similar IFN-g responses to titrated amounts of cognate peptide as well as to SIV-infected cells. In addition, the CTL clones showed variable CD107a (CTL degranulation marker) responses that did not correlate with their capacity to suppress virus replication. Thus, the clonal differences are not attributable to TCR avidity or typical effector responses, and point to a potential as yet unknown mechanism for CTL-mediated suppression of viral replication. These data emphasize that current assays for evaluating CTL responses in infected or vaccinated individuals do not fully capture the complex requirements for effective CTL-mediated control of virus replication. JF - Virology AU - Minang, J T AU - Trivett, M T AU - Coren, LV AU - Barsov, E V AU - Piatak, M AU - Ott, DE AU - Ohlen, C AD - SAIC-Frederick, Inc., NCI-Frederick, P.O. Box B, Frederick, MD 21702, USA, cohlen@ncifcrf.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 130 EP - 139 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 391 IS - 1 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - T-cell receptor KW - Data processing KW - g-Interferon KW - Replication KW - Major histocompatibility complex KW - CD8 antigen KW - Infection KW - Nef protein KW - Antiviral activity KW - Vaccination KW - Gag protein KW - CD4 antigen KW - Cytotoxicity KW - Human immunodeficiency virus KW - Avidity KW - Degranulation KW - Lymphocytes T KW - Macaca mulatta KW - Mutation KW - Simian immunodeficiency virus KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20178216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Nef-mediated+MHC+class+I+down-regulation+unmasks+clonal+differences+in+virus+suppression+by+SIV-specific+CD8+super%28%2B%29+T+cells+independent+of+IFN-g+and+CD107a+responses&rft.au=Minang%2C+J+T%3BTrivett%2C+M+T%3BCoren%2C+LV%3BBarsov%2C+E+V%3BPiatak%2C+M%3BOtt%2C+DE%3BOhlen%2C+C&rft.aulast=Minang&rft.aufirst=J&rft.date=2009-08-15&rft.volume=391&rft.issue=1&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2009.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - T-cell receptor; g-Interferon; Data processing; Replication; Major histocompatibility complex; CD8 antigen; Antiviral activity; Nef protein; Infection; Vaccination; Gag protein; Cytotoxicity; CD4 antigen; Avidity; Degranulation; Lymphocytes T; Mutation; Human immunodeficiency virus; Macaca mulatta; Simian immunodeficiency virus DO - http://dx.doi.org/10.1016/j.virol.2009.06.008 ER - TY - JOUR T1 - Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation. AN - 67575951; 19542225 AB - Nitric oxide (NO)-donating non-steroidal anti-inflammatory drugs (NSAIDs) represent a promising new class of drugs developed to provide a safer alternative than their conventional NSAID counterparts in chemoprevention. We tested the effects of NO-aspirin 2 on Phase I and Phase II carcinogen-metabolizing enzymes. In HepG2 human hepatoma cells and in LS180 colonic adenocarcinoma cells, NO-aspirin 2 inhibited 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD)-induced cytochrome P450 (CYP) enzyme activity and CYP1A1 and CYP1A2 mRNA expression. These effects were further characterized as being mediated through transcriptional regulation: NO-aspirin 2 inhibited binding of ligand (TCDD)-activated aryl hydrocarbon receptor to the CYP1A1 enhancer sequence; additionally, NO-aspirin 2 suppressed carcinogen-induced expression of CYP1A heterogeneous nuclear RNA. The fate of carcinogen metabolites depends not only on activation by CYP enzymes but also detoxification by Phase II enzymes. Both HepG2 and LS180 cells treated with NO-aspirin 2 showed an increase in glutathione S-transferase-P1 (GST-P1), glutamate-cysteine ligase (GCL), and NAD(P)H:quinone oxidoreductase-1 (NQO1) expression. Compared with two other NO-releasing compounds, diethylenetriamine-NO and the organic nitrate, isosorbide dinitrate, the inhibitory effects of NO-aspirin 2 on TCDD-induced CYP activity and mRNA expression were considerably more potent. Furthermore, aspirin alone had no inhibitory effect on TCDD-induced CYP activity, nor did aspirin up-regulate GCL, GST-P1, or NQO1 expression. Consequent to the effects on carcinogen-metabolizing enzymes, NO-aspirin 2 inhibited [3H]benzo[a]pyrene-DNA adduct formation and DNA damage elicited by TCDD or benzo[a]pyrene. Our results demonstrate that NO-aspirin 2 may be an effective chemopreventive agent by favorably affecting the inhibitory and enhancing effects of Phase I and Phase II carcinogen metabolism, thereby protecting DNA from carcinogenic insult. JF - The Journal of biological chemistry AU - MacDonald, Christopher J AU - Cheng, Robert Y S AU - Roberts, David D AU - Wink, David A AU - Yeh, Grace Chao AD - Cellular Defense and Carcinogenesis Section, Laboratory of Metabolism, Radiation Biology Branch, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, MD 21702, USA. Y1 - 2009/08/14/ PY - 2009 DA - 2009 Aug 14 SP - 22099 EP - 22107 VL - 284 IS - 33 SN - 0021-9258, 0021-9258 KW - Carcinogens KW - 0 KW - DNA Adducts KW - Polychlorinated Dibenzodioxins KW - Receptors, Aryl Hydrocarbon KW - Recombinant Proteins KW - Nitric Oxide KW - 31C4KY9ESH KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Aspirin KW - R16CO5Y76E KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Polychlorinated Dibenzodioxins -- chemistry KW - Dose-Response Relationship, Drug KW - Receptors, Aryl Hydrocarbon -- chemistry KW - Humans KW - Oxygen -- chemistry KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Cell Line, Tumor KW - Recombinant Proteins -- chemistry KW - Models, Biological KW - DNA Damage KW - Aspirin -- chemistry KW - Carcinogens -- chemistry KW - Nitric Oxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67575951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Modulation+of+carcinogen+metabolism+by+nitric+oxide-aspirin+2+is+associated+with+suppression+of+DNA+damage+and+DNA+adduct+formation.&rft.au=MacDonald%2C+Christopher+J%3BCheng%2C+Robert+Y+S%3BRoberts%2C+David+D%3BWink%2C+David+A%3BYeh%2C+Grace+Chao&rft.aulast=MacDonald&rft.aufirst=Christopher&rft.date=2009-08-14&rft.volume=284&rft.issue=33&rft.spage=22099&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.021063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1997 Jul 15;36(28):8640-8 [9214311] Mol Pharmacol. 1996 Sep;50(3):443-6 [8794879] Int J Cancer. 1997 Dec 10;73(6):897-902 [9399673] Genes Cells. 1997 Oct;2(10):645-54 [9427285] Am J Physiol. 1998 Mar;274(3 Pt 2):F573-9 [9530274] Life Sci. 1998;62(15):PL235-40 [9566780] Am J Med. 1998 Nov 2;105(5A):10S-16S [9855170] Chem Res Toxicol. 1999 Mar;12(3):237-46 [10077486] J Rheumatol Suppl. 1999 Apr;56:18-24 [10225536] Carcinogenesis. 1999 Oct;20(10):1885-91 [10506100] Carcinogenesis. 2005 Apr;26(4):803-9 [15661813] Toxicol In Vitro. 2005 Jun;19(4):491-503 [15826807] Toxicol In Vitro. 2005 Jun;19(4):505-16 [15826808] Mol Cell Biol. 2005 Jul;25(13):5317-28 [15964790] Carcinogenesis. 2006 Apr;27(4):803-10 [16267095] Chem Res Toxicol. 2006 May;19(5):719-28 [16696575] Apoptosis. 2006 Aug;11(8):1321-30 [16699954] Arch Toxicol. 2006 Sep;80(9):580-604 [16598496] Mol Pharmacol. 2006 Nov;70(5):1481-7 [16891617] J Physiol Pharmacol. 2006 Dec;57 Suppl 12:15-24 [17244951] Curr Top Med Chem. 2007;7(3):277-82 [17305570] J Med Chem. 2007 May 17;50(10):2424-31 [17441704] Biochem Biophys Res Commun. 2007 Jul 13;358(4):1096-101 [17512900] Lancet. 2004 Dec 4-10;364(9450):2021-9 [15582059] J Pharmacol Exp Ther. 2005 Mar;312(3):978-88 [15528453] Am J Med. 1999 Dec 13;107(6A):3S-8S; discussion 8S-10S [10628588] Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):779-82 [10639156] Cancer Lett. 1999 Dec 1;147(1-2):95-100 [10660094] Cancer Res. 2000 Feb 15;60(4):908-15 [10706104] Chem Res Toxicol. 2000 Mar;13(3):135-60 [10725110] Gastroenterology. 2000 Aug;119(2):512-20 [10930387] Biofactors. 2000;12(1-4):5-11 [11216505] Cancer Res. 2001 Apr 15;61(8):3285-9 [11309281] JAMA. 2001 Aug 22-29;286(8):954-9 [11509060] Chem Res Toxicol. 2002 Feb;15(2):170-9 [11849043] J Natl Cancer Inst. 2002 Feb 20;94(4):252-66 [11854387] Nat Rev Drug Discov. 2002 May;1(5):375-82 [12120413] J Pharmacol Exp Ther. 2002 Dec;303(3):1273-82 [12438552] Adv Enzyme Regul. 2003;43:121-34 [12791387] Prog Exp Tumor Res. 2003;37:1-24 [12795046] Cancer Res. 2004 Jan 1;64(1):429-34 [14729655] Curr Cancer Drug Targets. 2004 Feb;4(1):29-42 [14965265] Biochem Pharmacol. 2004 Jun 15;67(12):2197-205 [15163551] Lancet. 2004 May 29;363(9423):1751-6 [15172772] Chem Res Toxicol. 2004 Jun;17(6):827-38 [15206904] Trends Mol Med. 2004 Jul;10(7):324-30 [15242680] Nature. 1974 Nov 22;252(5481):326-8 [4473724] Pharmacol Rev. 1982 Jun;34(2):189-222 [6287505] Cancer Res. 1982 Dec;42(12):4875-917 [6814745] Cancer Res. 1986 May;46(5):2220-4 [3084065] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4651-5 [1675786] Biochim Biophys Acta. 1992 Nov 15;1171(1):19-26 [1420361] Carcinogenesis. 1993 Mar;14(3):475-82 [8384091] Am J Physiol. 1993 Sep;265(3 Pt 1):G418-22 [8214062] Int J Biochem. 1994 Mar;26(3):295-308 [8187927] Am J Kidney Dis. 1994 Jul;24(1):17-24 [8023820] Gastroenterology. 1994 Oct;107(4):1050-8 [7523213] Xenobiotica. 1995 Jul;25(7):677-88 [7483666] Biotechniques. 1996 Mar;20(3):470-7 [8679208] Br J Pharmacol. 1996 Apr;117(7):1421-6 [8730734] Crit Rev Biochem Mol Biol. 1995;30(6):445-600 [8770536] Vet Pathol. 1997 Nov;34(6):605-14 [9396142] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.021063 ER - TY - JOUR T1 - Structure and Energetics of Encapsidated DNA in Bacteriophage HK97 Studied by Scanning Calorimetry and Cryo-electron Microscopy AN - 21070582; 10252293 AB - Encapsidation of duplex DNA by bacteriophages represents an extreme case of genome condensation, reaching near-crystalline concentrations of DNA. The HK97 system is well suited to study this phenomenon in view of the detailed knowledge of its capsid structure. To characterize the interactions involved, we combined calorimetry with cryo-electron microscopy and native gel electrophoresis. We found that, as in other phages, HK97 DNA is organized in coaxially wound nested shells. When DNA-filled capsids (heads) are scanned in buffer containing 1 mM Mg super(2) super(+), DNA melting and capsid denaturation both contribute to the complex thermal profile between 82 super(o)C and 96 super(o)C. In other conditions (absence of Mg super(2) super(+) and lower ionic strength), DNA melting shifts to lower temperatures and the two events are resolved. Heads release their DNA at temperatures well below the onset of DNA melting or capsid denaturation. We suggest that, on heating, the internal pressure increases, causing the DNA to exit-probably via the portal vertex-while the capsid, although largely intact, sustains local damage that leads to an earlier onset of thermal denaturation. Heads differ structurally from empty capsids in the curvature of their protein shell, a change attributable to outwards pressure exerted by the DNA. We propose that this transition is sensed by the portal that is embedded in the capsid wall, whereupon the structure of the portal and its interactions with terminase, the packaging enzyme, are altered, thus signaling that packaging is at or approaching completion. JF - Journal of Molecular Biology AU - Duda, R L AU - Ross, P D AU - Cheng, N AU - Firek, BA AU - Hendrix, R W AU - Conway, J F AU - Steven, A C AD - National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA, stevena@mail.nih.gov Y1 - 2009/08/14/ PY - 2009 DA - 2009 Aug 14 SP - 471 EP - 483 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 391 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Calorimetry KW - Capsids KW - Condensation KW - DNA KW - Denaturation KW - Encapsidation KW - Enzymes KW - Gel electrophoresis KW - Genomes KW - Heads KW - Ionic strength KW - Magnesium KW - Melting KW - Microscopy KW - Phages KW - Pressure KW - Scanning KW - Shells KW - Signal transduction KW - Temperature effects KW - Thermal denaturation KW - Wounds KW - terminase KW - Phage HK97 KW - Bacteria KW - V 22320:Replication KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21070582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Structure+and+Energetics+of+Encapsidated+DNA+in+Bacteriophage+HK97+Studied+by+Scanning+Calorimetry+and+Cryo-electron+Microscopy&rft.au=Duda%2C+R+L%3BRoss%2C+P+D%3BCheng%2C+N%3BFirek%2C+BA%3BHendrix%2C+R+W%3BConway%2C+J+F%3BSteven%2C+A+C&rft.aulast=Duda&rft.aufirst=R&rft.date=2009-08-14&rft.volume=391&rft.issue=2&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2009.06.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Genomes; Capsids; Phages; Temperature effects; Denaturation; terminase; Ionic strength; Encapsidation; Enzymes; Gel electrophoresis; Wounds; Melting; Heads; Thermal denaturation; Scanning; Microscopy; DNA; Calorimetry; Condensation; Shells; Magnesium; Pressure; Signal transduction; Phage HK97; Bacteria DO - http://dx.doi.org/10.1016/j.jmb.2009.06.035 ER - TY - JOUR T1 - Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. AN - 67581661; 19679072 AB - Expansion of a polyglutamine tract in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA). We previously showed that Akt-mediated phosphorylation of AR reduces ligand binding and attenuates the mutant AR toxicity. Here, we show that in culture insulin-like growth factor 1 (IGF-1) reduces AR aggregation and increases AR clearance via the ubiquitin-proteasome system through phosphorylation of AR by Akt. In vivo, SBMA transgenic mice overexpressing a muscle-specific isoform of IGF-1 selectively in skeletal muscle show evidence of increased Akt activation and AR phosphorylation and decreased AR aggregation. Augmentation of IGF-1/Akt signaling rescues behavioral and histopathological abnormalities, extends the life span, and reduces both muscle and spinal cord pathology of SBMA mice. This study establishes IGF-1/Akt-mediated inactivation of mutant AR as a strategy to counteract disease in vivo and demonstrates that skeletal muscle is a viable target tissue for therapeutic intervention in SBMA. JF - Neuron AU - Palazzolo, Isabella AU - Stack, Conor AU - Kong, Lingling AU - Musaro, Antonio AU - Adachi, Hiroaki AU - Katsuno, Masahisa AU - Sobue, Gen AU - Taylor, J Paul AU - Sumner, Charlotte J AU - Fischbeck, Kenneth H AU - Pennuto, Maria AD - Neurogenetics Branch, NINDS, NIH, Bethesda, MD 20892, USA. Y1 - 2009/08/13/ PY - 2009 DA - 2009 Aug 13 SP - 316 EP - 328 VL - 63 IS - 3 KW - Enzyme Inhibitors KW - 0 KW - Muscle Proteins KW - Peptides KW - Receptors, Androgen KW - Ubiquitin KW - polyglutamine KW - 26700-71-0 KW - Serine KW - 452VLY9402 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Pik3cd protein, mouse KW - EC 2.7.1.137 KW - Oncogene Protein v-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Humans KW - Disease Models, Animal KW - Trinucleotide Repeat Expansion -- drug effects KW - Mice, Transgenic KW - Serine -- metabolism KW - Behavior, Animal -- drug effects KW - Oncogene Protein v-akt -- metabolism KW - Phosphorylation -- genetics KW - Receptors, Androgen -- metabolism KW - Trinucleotide Repeat Expansion -- physiology KW - Cell Line, Transformed KW - Time Factors KW - Muscle Proteins -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Receptors, Androgen -- genetics KW - Peptides -- metabolism KW - Mice KW - Phosphorylation -- drug effects KW - Muscle Proteins -- genetics KW - Transfection -- methods KW - Ubiquitin -- metabolism KW - Cercopithecus aethiops KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Behavior, Animal -- physiology KW - Mutation -- genetics KW - Peptides -- genetics KW - Insulin-Like Growth Factor I -- genetics KW - Muscular Atrophy, Spinal -- genetics KW - Muscular Atrophy, Spinal -- mortality KW - Muscular Atrophy, Spinal -- pathology KW - Muscular Atrophy, Spinal -- therapy KW - Insulin-Like Growth Factor I -- metabolism KW - Gene Expression Regulation -- drug effects KW - Muscular Atrophy -- physiopathology KW - Muscle, Skeletal -- metabolism KW - Muscle, Skeletal -- drug effects KW - Insulin-Like Growth Factor I -- pharmacology KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67581661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Overexpression+of+IGF-1+in+muscle+attenuates+disease+in+a+mouse+model+of+spinal+and+bulbar+muscular+atrophy.&rft.au=Palazzolo%2C+Isabella%3BStack%2C+Conor%3BKong%2C+Lingling%3BMusaro%2C+Antonio%3BAdachi%2C+Hiroaki%3BKatsuno%2C+Masahisa%3BSobue%2C+Gen%3BTaylor%2C+J+Paul%3BSumner%2C+Charlotte+J%3BFischbeck%2C+Kenneth+H%3BPennuto%2C+Maria&rft.aulast=Palazzolo&rft.aufirst=Isabella&rft.date=2009-08-13&rft.volume=63&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=1097-4199&rft_id=info:doi/10.1016%2Fj.neuron.2009.07.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-28 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2002 Sep 10;59(5):770-2 [12221177] Neuron. 2002 Aug 29;35(5):843-54 [12372280] Hum Mol Genet. 2003 Apr 1;12(7):749-57 [12651870] Nat Med. 2003 Jun;9(6):768-73 [12754502] Science. 2003 Aug 8;301(5634):839-42 [12907804] Cell. 2004 Apr 30;117(3):399-412 [15109499] Mol Cell. 2004 May 7;14(3):395-403 [15125842] Nat Med. 2004 Jul;10 Suppl:S10-7 [15272267] J Cell Biol. 1990 Apr;110(4):1307-17 [2157718] Nature. 1991 Jul 4;352(6330):77-9 [2062380] Neuron. 1992 May;8(5):983-93 [1375039] J Neurobiol. 1993 Dec;24(12):1578-88 [8301266] J Biol Chem. 1994 Feb 18;269(7):5241-8 [8106507] J Neurosci Res. 1993 Dec 15;36(6):663-71 [8145295] Phys Med Rehabil Clin N Am. 2008 Aug;19(3):479-94, viii [18625411] Curr Opin Pharmacol. 2008 Dec;8(6):752-8 [18775514] Neurology. 2008 Nov 25;71(22):1770-5 [19029516] Neurobiol Dis. 2009 Mar;33(3):342-53 [19084066] Ann Neurol. 2009 Feb;65(2):140-50 [19259967] Mol Cell Biol. 1994 Dec;14(12):8051-7 [7969143] J Biol Chem. 1995 May 19;270(20):12109-16 [7744859] Endocr Rev. 1996 Oct;17(5):481-517 [8897022] EMBO J. 1996 Dec 2;15(23):6541-51 [8978681] Neurology. 1997 Dec;49(6):1621-30 [9409357] Neurology. 1998 Aug;51(2):583-6 [9710040] Hum Mol Genet. 1999 May;8(5):731-41 [10196362] J Cell Biol. 2005 Jan 17;168(2):193-9 [15657392] Physiol Genomics. 2005 Jul 14;22(2):227-43 [15840640] Curr Opin Cell Biol. 2005 Dec;17(6):596-603 [16226444] Exp Neurol. 2006 Jul;200(1):8-18 [16513111] J Clin Invest. 2006 Oct;116(10):2663-72 [16981011] Methods Enzymol. 2006;412:33-48 [17046650] J Biol Chem. 2007 Feb 2;282(5):3157-64 [17121819] Neurobiol Aging. 2007 Jul;28(7):1099-111 [16781019] Cell Cycle. 2007 May 15;6(10):1242-8 [17495527] Hum Mol Genet. 2007 Jul 1;16(13):1593-603 [17470458] Annu Rev Neurosci. 2007;30:575-621 [17417937] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18259-64 [17984063] Cell Metab. 2007 Dec;6(6):472-83 [18054316] J Neurol Sci. 2008 Jan 15;264(1-2):100-5 [17854832] Neuron. 2008 Feb 7;57(3):393-405 [18255032] Neuron. 2008 Mar 27;57(6):809-18 [18367082] Physiology (Bethesda). 2008 Jun;23:160-70 [18556469] Nat Genet. 2001 Feb;27(2):195-200 [11175789] Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7200-5 [11404460] J Cell Sci. 2001 Aug;114(Pt 16):2903-10 [11686294] Nat Cell Biol. 2001 Nov;3(11):1009-13 [11715022] Nat Cell Biol. 2001 Nov;3(11):1014-9 [11715023] Dev Cell. 2002 Jun;2(6):831-7 [12062094] EMBO J. 2002 Aug 1;21(15):4037-48 [12145204] Comment In: Neuron. 2009 Aug 13;63(3):277-8 [19679066] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuron.2009.07.019 ER - TY - CPAPER T1 - V(D)J recombination: from regulation to 3D assembly T2 - Registration Science Programme Abstract Submission General Information Machines on genes: enzymes that make, break, and move DNA and RNA AN - 40407305; 5303533 JF - Registration Science Programme Abstract Submission General Information Machines on genes: enzymes that make, break, and move DNA and RNA AU - Yang, Wei Y1 - 2009/08/12/ PY - 2009 DA - 2009 Aug 12 KW - V(D)J recombination KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40407305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Registration+Science+Programme+Abstract+Submission+General+Information+Machines+on+genes%3A+enzymes+that+make%2C+break%2C+and+move+DNA+and+RNA&rft.atitle=V%28D%29J+recombination%3A+from+regulation+to+3D+assembly&rft.au=Yang%2C+Wei&rft.aulast=Yang&rft.aufirst=Wei&rft.date=2009-08-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Registration+Science+Programme+Abstract+Submission+General+Information+Machines+on+genes%3A+enzymes+that+make%2C+break%2C+and+move+DNA+and+RNA&rft.issn=&rft_id=info:doi/ L2 - http://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/ Programme/MeetingNo/SA097/Default.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matrix Topography Control of Cell Migration and Cell Adhesions T2 - Engineering Cell Biology III AN - 40403826; 5304079 JF - Engineering Cell Biology III AU - Doyle, Andrew Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Migration KW - Cell adhesion KW - Topography KW - Cell migration KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40403826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Engineering+Cell+Biology+III&rft.atitle=Matrix+Topography+Control+of+Cell+Migration+and+Cell+Adhesions&rft.au=Doyle%2C+Andrew&rft.aulast=Doyle&rft.aufirst=Andrew&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Engineering+Cell+Biology+III&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/9akfin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The structural basis of protein-based inheritance T2 - 2009 Gordon Research Conference on Epigenetics AN - 40403656; 5302298 JF - 2009 Gordon Research Conference on Epigenetics AU - Wickner, Reed Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Heredity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40403656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Epigenetics&rft.atitle=The+structural+basis+of+protein-based+inheritance&rft.au=Wickner%2C+Reed&rft.aulast=Wickner&rft.aufirst=Reed&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Epigenetics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=epigen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNAi-mediated Epigenetic Control of the Genome T2 - 2009 Gordon Research Conference on Epigenetics AN - 40402080; 5302310 JF - 2009 Gordon Research Conference on Epigenetics AU - Grewal, Shiv Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Genomes KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40402080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Epigenetics&rft.atitle=RNAi-mediated+Epigenetic+Control+of+the+Genome&rft.au=Grewal%2C+Shiv&rft.aulast=Grewal&rft.aufirst=Shiv&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Epigenetics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=epigen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Differentiation through Epigenetics and Selective Chromatid Segregation T2 - 2009 Gordon Research Conference on Epigenetics AN - 40402021; 5302285 JF - 2009 Gordon Research Conference on Epigenetics AU - Klar, Amar Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Chromatids KW - Differentiation KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40402021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Epigenetics&rft.atitle=Cellular+Differentiation+through+Epigenetics+and+Selective+Chromatid+Segregation&rft.au=Klar%2C+Amar&rft.aulast=Klar&rft.aufirst=Amar&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Epigenetics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=epigen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficiency of Repairing Polymerase- and Strand-Specific DNA Replication Errors T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40349629; 5261461 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Kunkel, Thomas Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Efficiency KW - Replication KW - DNA biosynthesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Efficiency+of+Repairing+Polymerase-+and+Strand-Specific+DNA+Replication+Errors&rft.au=Kunkel%2C+Thomas&rft.aulast=Kunkel&rft.aufirst=Thomas&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatin Architectural Proteins and Genotoxic Stress T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40348837; 5261472 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Bustin, Michael Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Genotoxicity KW - Stress KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Chromatin+Architectural+Proteins+and+Genotoxic+Stress&rft.au=Bustin%2C+Michael&rft.aulast=Bustin&rft.aufirst=Michael&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The expanding p53 universe of target genes T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40346902; 5261488 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Resnick, Michael Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - P53 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=The+expanding+p53+universe+of+target+genes&rft.au=Resnick%2C+Michael&rft.aulast=Resnick&rft.aufirst=Michael&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent insights into the mechansims of spontaneous and damage-induced mutagenesis in Escherichia coli T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40343672; 5261467 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Woodgate, Roger Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Mutagenesis KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Recent+insights+into+the+mechansims+of+spontaneous+and+damage-induced+mutagenesis+in+Escherichia+coli&rft.au=Woodgate%2C+Roger&rft.aulast=Woodgate&rft.aufirst=Roger&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Association Studies - New Clues to Biologic Function in Human Cancer T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40343067; 5261451 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Hunter, David Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Genome-Wide+Association+Studies+-+New+Clues+to+Biologic+Function+in+Human+Cancer&rft.au=Hunter%2C+David&rft.aulast=Hunter&rft.aufirst=David&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Damage-induced localized hypermutability T2 - 2009 Gordon Research Conference on Genetic Toxicology AN - 40342922; 5261465 JF - 2009 Gordon Research Conference on Genetic Toxicology AU - Gordenin, Dmitry Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.atitle=Damage-induced+localized+hypermutability&rft.au=Gordenin%2C+Dmitry&rft.aulast=Gordenin&rft.aufirst=Dmitry&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Genetic+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gentox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of neurodegeneration in ATP7A copper transporter-related disorders T2 - 2009 Gordon Research Conference on Cell Biology of Metals AN - 40326649; 5261671 JF - 2009 Gordon Research Conference on Cell Biology of Metals AU - Kaler, Stephen Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Copper KW - Neurodegeneration KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40326649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cell+Biology+of+Metals&rft.atitle=Mechanisms+of+neurodegeneration+in+ATP7A+copper+transporter-related+disorders&rft.au=Kaler%2C+Stephen&rft.aulast=Kaler&rft.aufirst=Stephen&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cell+Biology+of+Metals&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cellbiomet LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pcbp Family of Iron Chaperones T2 - 2009 Gordon Research Conference on Cell Biology of Metals AN - 40325482; 5261677 JF - 2009 Gordon Research Conference on Cell Biology of Metals AU - Philpott, Caroline Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Iron KW - Chaperones KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cell+Biology+of+Metals&rft.atitle=The+Pcbp+Family+of+Iron+Chaperones&rft.au=Philpott%2C+Caroline&rft.aulast=Philpott&rft.aufirst=Caroline&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cell+Biology+of+Metals&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cellbiomet LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Critical review of cancer epidemiologic studies and future directions T2 - 2009 Gordon Research Conference on Drinking Water Disinfection By-Products AN - 40319441; 5261625 JF - 2009 Gordon Research Conference on Drinking Water Disinfection By-Products AU - Cantor, Ken Y1 - 2009/08/09/ PY - 2009 DA - 2009 Aug 09 KW - Cancer KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40319441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Drinking+Water+Disinfection+By-Products&rft.atitle=Critical+review+of+cancer+epidemiologic+studies+and+future+directions&rft.au=Cantor%2C+Ken&rft.aulast=Cantor&rft.aufirst=Ken&rft.date=2009-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Drinking+Water+Disinfection+By-Products&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=drinkwater LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. AN - 733967426; 19549813 AB - Copper is an essential trace element; however, at supraphysiological levels, it can be extremely toxic. Microarray data from HepG2 cells exposed to 100, 200, 400, and 600 microM copper for 4, 8, 12 and 24 h were generated and analyzed. Principal components, K-means, and hierarchical clustering, interactome, and pathway mapping analyses indicated that these exposure conditions induce physiological and toxicological changes in the HepG2 transcriptome. As a general trend, when the level of toxicity increases, the number and diversity of affected genes, Gene Ontology categories, regulatory pathways, and complexity of interactomes increase. Physiological responses to copper include transition metal ion binding and responses to stress/stimulus, whereas toxicological responses include apoptosis, morphogenesis, and negative regulation of biomolecule metabolism. The global gene expression profile was overlaid onto biomolecular interaction networks and signal transduction cascades using pathway mapping and interactome identification. This analysis indicated that copper modulates signal transduction pathways associated with MAPK, NF-kappaB, death receptor, IGF-I, hypoxia, IL-10, IL-2, IL-6, EGF, Toll-like receptor, protein ubiquitination, xenobiotic metabolism, leukocyte extravasation, complement and coagulation, and sonic hedgehog signaling. These results provide insights into the global and molecular mechanisms regulating the physiological and toxicological responses to metal exposure. JF - Physiological genomics AU - Song, Min Ok AU - Li, Jianying AU - Freedman, Jonathan H AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2009/08/07/ PY - 2009 DA - 2009 Aug 07 SP - 386 EP - 401 VL - 38 IS - 3 KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Dose-Response Relationship, Drug KW - Humans KW - Principal Component Analysis KW - Gene Regulatory Networks KW - Cell Line, Tumor KW - Models, Biological KW - Cluster Analysis KW - Signal Transduction -- physiology KW - Gene Expression Profiling KW - Signal Transduction -- drug effects KW - Copper -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733967426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+genomics&rft.atitle=Physiological+and+toxicological+transcriptome+changes+in+HepG2+cells+exposed+to+copper.&rft.au=Song%2C+Min+Ok%3BLi%2C+Jianying%3BFreedman%2C+Jonathan+H&rft.aulast=Song&rft.aufirst=Min&rft.date=2009-08-07&rft.volume=38&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Physiological+genomics&rft.issn=1531-2267&rft_id=info:doi/10.1152%2Fphysiolgenomics.00083.2009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE9539; GEO N1 - SuppNotes - Cited By: Cell. 1987 Jun 19;49(6):729-39 [3034432] Biochim Biophys Acta. 1989 Aug 18;992(2):145-54 [2547449] Toxicol Appl Pharmacol. 1991 Sep 15;110(3):477-85 [1949015] J Biol Inorg Chem. 2007 May;12(4):495-507 [17211630] PLoS Genet. 2008 Apr;4(4):e1000053 [18437200] Biometals. 2009 Feb;22(1):149-57 [19130267] Toxicol In Vitro. 2003 Oct-Dec;17(5-6):553-9 [14599444] Am J Physiol Cell Physiol. 2004 Feb;286(2):C293-301 [14576086] Funct Dev Morphol. 1991;1(3):17-22 [1802039] Ann Clin Lab Sci. 1993 Mar-Apr;23(2):111-20 [8457140] Am J Clin Nutr. 1996 May;63(5):842S-5S [8615372] Ecotoxicol Environ Saf. 1997 Mar;36(2):183-8 [9126437] Chem Biol. 1997 Aug;4(8):549-60 [9281528] Ecotoxicol Environ Saf. 1998 Jan;39(1):41-7 [9515074] Am J Clin Nutr. 1998 May;67(5 Suppl):1069S-1073S [9587154] Am J Clin Nutr. 1998 May;67(5 Suppl):1091S-1097S [9587158] Sci Total Environ. 1998 Sep 29;221(1):1-10 [9810731] Science. 1999 Apr 30;284(5415):770-6 [10221902] J Cell Physiol. 1999 Jul;180(1):105-13 [10362023] Med J Aust. 1999 May 17;170(10):510 [10376036] J Toxicol Clin Toxicol. 1999;37(2):217-30 [10382557] J Nutr. 1999 Jul;129(7):1251-60 [10395584] Biochem Biophys Res Commun. 1999 Aug 2;261(2):225-32 [10425169] Hum Mol Genet. 1999 Sep;8(9):1665-71 [10441329] Am J Physiol. 1958 Sep;194(3):581-4 [13571430] Bioinformatics. 2004 Nov 22;20(17):3246-8 [15180930] Chem Biol Interact. 2005 Jan 15;151(2):71-82 [15698579] Chem Biol Interact. 2005 Feb 10;151(3):167-76 [15733538] Cytokine Growth Factor Rev. 2005 Feb;16(1):15-34 [15733830] Expert Opin Ther Targets. 2005 Feb;9(1):83-99 [15757484] Curr Med Chem. 2005;12(10):1161-208 [15892631] Physiol Genomics. 2005 Aug 11;22(3):356-67 [15886332] Mol Cell Biochem. 2005 Nov;279(1-2):141-7 [16283523] Biol Trace Elem Res. 2005 Winter;108(1-3):271-7 [16327078] Am J Pathol. 2006 Feb;168(2):423-34 [16436657] Biol Res. 2006;39(1):125-42 [16629173] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Biol Chem. 2007 Mar 16;282(11):8343-55 [17205981] Cancer Res. 2007 Mar 15;67(6):2736-46 [17363595] Oncology. 2003;65(4):323-30 [14707452] Biochem J. 2004 Mar 1;378(Pt 2):617-24 [14627437] Arch Environ Contam Toxicol. 2004 Jan;46(1):61-6 [15025165] Toxicology. 2004 Mar 1;196(1-2):57-64 [15036756] Environ Toxicol Chem. 2004 Apr;23(4):960-7 [15095892] BMC Bioinformatics. 2004 Feb 18;5:16 [14975175] Bioinformatics. 2004 Jun 12;20(9):1453-4 [14871861] Chem Biol Interact. 2004 Jul 20;148(3):115-23 [15276868] J Biol Chem. 1967 Apr 10;242(7):1574-8 [6023222] J Nutr. 2000 May;130(5):1085-8 [10801901] Hum Exp Toxicol. 2000 Jun;19(6):367-76 [10962511] J Hepatol. 2000 Sep;33(3):415-22 [11019997] J Biol Chem. 2000 Oct 13;275(41):32310-6 [10922376] Cell Mol Life Sci. 2000 Nov;57(12):1672-81 [11130174] Environ Toxicol Chem. 2001 Jul;20(7):1579-83 [11434301] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] Bioinformatics. 2002;18 Suppl 1:S233-40 [12169552] Genome Biol. 2002 Aug 30;3(9):research0048 [12225587] Semin Cell Dev Biol. 2003 Apr;14(2):143-50 [12651098] Biol Trace Elem Res. 2003 Feb;91(2):137-44 [12719608] Atherosclerosis. 2003 Jul;169(1):71-6 [12860252] Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):345-55 [12927909] Biol Trace Elem Res. 2003 Aug;94(2):105-12 [12958401] Genome Res. 2003 Nov;13(11):2498-504 [14597658] J Lab Clin Med. 1976 Sep;88(3):375-88 [822110] Cancer Res. 1978 Oct;38(10):3483-6 [80265] Am J Pathol. 1980 Jun;99(3):715-30 [7386600] Biochem J. 1984 Apr 1;219(1):1-14 [6326753] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/physiolgenomics.00083.2009 ER - TY - JOUR T1 - Gene expression changes following extinction testing in a heroin behavioral incubation model. AN - 67608249; 19664213 AB - A number of gene expression studies have investigated changes induced by drug exposure, but few reports describe changes that persist following relapse. In this study, genome-wide analysis of gene expression was conducted following an extinction session (90 min) in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. As an important modulator of goal-directed behavior, the medial prefrontal cortex (mPFC) was the target of genomic analysis. Rats were trained to self-administer heroin during 3 h daily sessions for 14 d. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session in which they could seek heroin, but received none. Extinction sessions were conducted on groups after either 1 d or 14 d of drug-free enforced abstinence to demonstrate behavioral incubation. Behavioral data demonstrated incubation (increased expression) of heroin-seeking and goal-directed behavior after the 14 d abstinent period. That is, following 14 d of enforced abstinence, animals displayed heightened drug-seeking behavior when returned to the environment where they had previously received heroin. This increased drug-seeking took place despite the fact that they received no drug during this extinction session. Whole genome gene expression analysis was performed and results were confirmed by quantitative real-time PCR (RT-qPCR). Microarrays identified 66 genes whose expression was identified as changed by at least 1.4 fold (p < 0.02) following 14 d of abstinence and the 90-minute extinction session compared to the saline treated controls. Orthogonal confirmation by RT-qPCR demonstrated significant alterations in bdnf, calb1, dusp5, dusp6, egr1, npy, rgs2. Ontological analysis indicates that several of the genes confirmed to be changed are important for neuroplasticity, and through that role may impact learning and behavior. The importance of drug-seeking behavior and memory of previous drug-taking sessions suggest that such genes may be important for relapse. The global gene expression analysis adds to the knowledge of heroin-induced changes and further highlights similarities between heroin and other drugs of abuse. JF - BMC neuroscience AU - Kuntz-Melcavage, Kara L AU - Brucklacher, Robert M AU - Grigson, Patricia S AU - Freeman, Willard M AU - Vrana, Kent E AD - Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA. kuntzmelcavagkl@ninds.nih.gov Y1 - 2009/08/07/ PY - 2009 DA - 2009 Aug 07 SP - 95 VL - 10 KW - Nerve Tissue Proteins KW - 0 KW - Heroin KW - 70D95007SX KW - Index Medicus KW - Rats KW - Animals KW - Self Administration KW - Oligonucleotide Array Sequence Analysis KW - Prefrontal Cortex -- physiology KW - Conditioning, Operant KW - Up-Regulation -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Behavior, Addictive -- genetics KW - Heroin -- administration & dosage KW - Gene Expression Profiling KW - Extinction, Psychological -- physiology KW - Nerve Tissue Proteins -- genetics KW - Heroin Dependence -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67608249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+neuroscience&rft.atitle=Gene+expression+changes+following+extinction+testing+in+a+heroin+behavioral+incubation+model.&rft.au=Kuntz-Melcavage%2C+Kara+L%3BBrucklacher%2C+Robert+M%3BGrigson%2C+Patricia+S%3BFreeman%2C+Willard+M%3BVrana%2C+Kent+E&rft.aulast=Kuntz-Melcavage&rft.aufirst=Kara&rft.date=2009-08-07&rft.volume=10&rft.issue=&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=BMC+neuroscience&rft.issn=1471-2202&rft_id=info:doi/10.1186%2F1471-2202-10-95 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-24 N1 - Date created - 2009-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2005 Sep 15;47(6):795-801 [16157275] J Neurochem. 2005 Dec;95(5):1481-94 [16219028] Nat Rev Genet. 2006 Jan;7(1):55-65 [16369572] J Neurosci. 2006 May 31;26(22):5881-7 [16738229] J Neurochem. 2006 Aug;98(3):905-15 [16787418] Prog Brain Res. 2006;158:173-95 [17027697] Proteins. 2007 Jan 1;66(1):253-8 [17078075] Brain. 2007 May;130(Pt 5):1330-7 [17405766] Oncogene. 2007 May 14;26(22):3203-13 [17496916] Eur J Neurosci. 2007 Aug;26(3):757-66 [17651427] Physiol Behav. 2007 Sep 10;92(1-2):263-71 [17586536] Cereb Cortex. 2007 Dec;17(12):2820-7 [17322558] Synapse. 2008 Mar;62(3):193-204 [18081184] Biol Psychiatry. 2008 Feb 1;63(3):256-62 [17719014] Mol Psychiatry. 2008 Apr;13(4):417-28 [18195715] Psychopharmacology (Berl). 2008 May;198(1):77-91 [18311559] Neuropharmacology. 2008 Jun;54(7):1107-11 [18410947] J Neurosci. 2008 May 28;28(22):5836-45 [18509045] J Neurosci. 2008 Jun 4;28(23):6046-53 [18524910] Pharmacol Biochem Behav. 2008 Sep;90(3):349-56 [18466961] Pharmacol Biochem Behav. 2008 Sep;90(3):344-8 [18471868] Neuropsychopharmacology. 2008 Jul;33(8):1807-17 [17851536] Neuropsychopharmacology. 2008 Sep;33(10):2474-82 [18033234] Brain Struct Funct. 2008 Sep;213(1-2):215-27 [18488248] Behav Brain Res. 2008 Dec 1;194(1):39-43 [18639589] Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3147-58 [18640921] Neuropharmacology. 2009;56 Suppl 1:177-85 [18565549] Neuropharmacology. 2009;56 Suppl 1:18-31 [18725236] Brain Res. 2008 Nov 6;1239:42-8 [18786515] Nat Genet. 2000 Nov;26(3):277-81 [11062465] Biochem J. 2000 Dec 15;352 Pt 3:701-8 [11104676] J Neurochem. 2001 Nov;79(3):679-88 [11701771] Methods. 2001 Dec;25(4):402-8 [11846609] Behav Neurosci. 2002 Apr;116(2):321-33 [11996317] Pharmacol Biochem Behav. 2002 Nov;73(4):813-9 [12213526] J Biol Chem. 2003 Feb 14;278(7):5205-13 [12435740] Neuroscience. 2003;120(2):551-71 [12890524] Forensic Sci Int. 2004 Feb 10;140(1):13-20 [15013161] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Bioinformatics. 2004 Jun 12;20(9):1464-5 [14962934] J Neurochem. 2004 Jul;90(1):220-30 [15198681] BMC Bioinformatics. 2004 Sep 6;5:124 [15350198] Eur J Pharmacol. 2004 Oct 1;500(1-3):487-97 [15464054] Neuropharmacology. 2004;47 Suppl 1:101-10 [15464129] Neuropharmacology. 2004;47 Suppl 1:214-26 [15464139] Neuropharmacology. 2004;47 Suppl 1:242-55 [15464141] Neurochem Res. 1993 Jan;18(1):5-13 [8385277] J Biol Chem. 1995 Jan 20;270(3):1156-60 [7836374] Biotechniques. 1995 Dec;19(6):942-5 [8747660] Eur J Neurosci. 1998 Mar;10(3):1196-201 [9753188] Brain Res Brain Res Rev. 1998 Dec;28(3):309-69 [9858756] Alcohol Clin Exp Res. 2005 Apr;29(4):584-90 [15834223] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8746-51 [15937104] Brain Res. 2005 Jul 5;1049(1):128-31 [15935999] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2202-10-95 ER - TY - JOUR T1 - Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. AN - 733971132; 19656375 AB - Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse. 600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated. Increased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39-2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77-2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09-3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01-3.29). These data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis. JF - BMC cancer AU - Gao, Ying AU - Hu, Nan AU - Han, XiaoYou AU - Giffen, Carol AU - Ding, Ti AU - Goldstein, Alisa AU - Taylor, Philip AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. gaoying@mail.nih.gov Y1 - 2009/08/05/ PY - 2009 DA - 2009 Aug 05 SP - 269 VL - 9 KW - Index Medicus KW - Risk KW - Regression Analysis KW - Odds Ratio KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Family Health KW - Male KW - Female KW - China KW - Stomach Neoplasms -- mortality KW - Stomach Neoplasms -- genetics KW - Esophageal Neoplasms -- genetics KW - Esophageal Neoplasms -- diagnosis KW - Stomach Neoplasms -- diagnosis KW - Esophageal Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733971132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Family+history+of+cancer+and+risk+for+esophageal+and+gastric+cancer+in+Shanxi%2C+China.&rft.au=Gao%2C+Ying%3BHu%2C+Nan%3BHan%2C+XiaoYou%3BGiffen%2C+Carol%3BDing%2C+Ti%3BGoldstein%2C+Alisa%3BTaylor%2C+Philip&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2009-08-05&rft.volume=9&rft.issue=&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-9-269 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Cancer. 1991;27(10):1336 [1835609] Am J Hum Genet. 2000 Jul;67(1):110-9 [10841811] Jpn J Cancer Res. 1992 Jun;83(6):568-75 [1644660] Int J Epidemiol. 1992 Oct;21(5):877-82 [1468848] Cancer Causes Control. 1993 May;4(3):195-202 [8318635] Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):15-8 [8118379] Int J Cancer. 1994 Jun 15;57(6):775-80 [8206671] Cancer Epidemiol Biomarkers Prev. 1994 Jul-Aug;3(5):387-92 [7920205] Am J Pathol. 1995 Sep;147(3):593-600 [7677173] Jpn J Cancer Res. 1996 Oct;87(10):1025-8 [8957058] Int J Epidemiol. 1997 Dec;26(6):1159-65 [9447394] Int J Cancer. 1998 May 18;76(4):468-71 [9590119] Int J Cancer. 1998 Jun 10;76(6):801-5 [9626344] Zhonghua Liu Xing Bing Xue Za Zhi. 1997 Oct;18(5):275-8 [9812488] Am J Epidemiol. 1999 Mar 1;149(5):454-62 [10067905] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cancer Res. 2005 May 1;65(9):3548-54 [15867347] Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1390-3 [15941946] Br J Cancer. 2001 Feb 2;84(3):388-91 [11161404] Int J Cancer. 2001 Jul 1;93(1):148-52 [11391635] Int J Cancer. 2002 Feb 10;97(5):688-94 [11807799] Surgery. 2002 Jan;131(1 Suppl):S1-6 [11821780] Gut. 2002 Sep;51(3):323-8 [12171951] J Clin Gastroenterol. 2003 Jan;36(1):30-3 [12488704] World J Gastroenterol. 2003 Feb;9(2):214-8 [12532434] Eur J Cancer Prev. 2003 Jun;12(3):183-9 [12771555] Cancer Res. 2003 Jul 15;63(14):3872-6 [12873975] Int J Epidemiol. 2003 Aug;32(4):579-83 [12913033] J Gastrointest Surg. 2004 Mar-Apr;8(3):240-4 [15019915] Br J Cancer. 2004 Apr 5;90(7):1402-6 [15054463] Am J Gastroenterol. 2004 Jul;99(7):1250-7 [15233662] Sci Sin. 1975 Jan-Feb;18(1):131-48 [1145176] Cancer. 1985 Oct 15;56(8):2112-6 [4027937] Chin Med J (Engl). 1985 Oct;98(10):749-52 [3938702] Int J Cancer. 1989 May 15;43(5):755-61 [2714880] Cancer Res. 1990 Apr 15;50(8):2268-74 [2317814] Jpn J Cancer Res. 1990 Jun-Jul;81(6-7):584-9 [2119361] Zhonghua Yi Xue Za Zhi. 1990 Dec;70(12):679-81, 46 [1963371] Gastroenterology. 2005 Aug;129(2):565-76 [16083713] Int J Cancer. 2006 Sep 1;119(5):1047-51 [16570268] World J Gastroenterol. 2006 Jul 7;12(25):4033-7 [16810754] J Gastrointest Surg. 2006 Jul-Aug;10(7):1023-32 [16843873] Gastroenterology. 2006 Oct;131(4):1271-83 [17030196] Fam Cancer. 2006;5(4):343-52 [16724246] Semin Radiat Oncol. 2007 Jan;17(1):2-9 [17185192] BMC Cancer. 2006;6:287 [17173682] Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Jun;151(1):17-20 [17690734] World J Gastroenterol. 2007 Nov 21;13(43):5760-4 [17963305] Br J Cancer. 2008 Jun 3;98(11):1857-63 [18475303] JAMA. 2008 Jun 4;299(21):2515-23 [18523220] Int J Cancer. 2008 Sep 15;123(6):1429-32 [18567000] Breast Cancer Res. 2008;10(3):R47 [18507837] Clin Cancer Res. 2008 Aug 1;14(15):4787-93 [18676749] Cancer. 2000 Sep 15;89(6):1205-13 [11002214] Clin Cancer Res. 1999 Nov;5(11):3476-82 [10589761] J Natl Cancer Inst. 1992 May 20;84(10):771-6 [1573663] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2407-9-269 ER - TY - JOUR T1 - The G18V CRYGS mutation associated with human cataracts increases gammaS-crystallin sensitivity to thermal and chemical stress. AN - 67617022; 19558189 AB - GammaS-crystallin, important in maintaining lens transparency, is a monomeric betagamma-crystallin comprising two paired homologous domains, each with two Greek key motifs. An autosomal dominant cortical progressive cataract has been associated with a G18V mutation in human gammaS-crystallin. To investigate the molecular mechanism of this cataract and confirm the causative nature of the G18V mutation, we examined resultant changes in conformation and stability. Human gammaS-crystallin cDNA was cloned into pET-20b(+), and the G18V mutant was generated by site-directed mutagenesis. Recombinant HgammaS-crystallins were expressed in Escherichia coli and purified by ion-exchange and size-exclusion chromatography. By analytical ultracentrifugation wild-type and mutant HgammaS-crystallins are monomers of about 21.95 +/- 0.21 and 20.89 +/- 0.18 kDa, respectively, and have similar secondary structures by far-UV CD. In increasing levels of guanidine hydrochloride (GuHCl), a sharp red shift in fluorescence lambda(max) and increase in emission correlating with exposure of tryptophans to the protein surface are detected earlier in the mutant protein. Under thermal stress, the G18V mutant begins to show changes in tryptophan fluorescence above 42 degrees C and shows a Tm of 65 degrees C as monitored by CD at 218 nm, while wild-type HgammaS-crystallin is very stable with Tm values of 75.5 and 75.0 degrees C as measured by fluorescence and CD, respectively. Equilibrium unfolding/refolding experiments as a function of GuHCl confirm the relative instability of the G18V mutant. Wild-type HgammaS-crystallin exhibits a two-state transition and reversible refolding above 1.0 M GuHCl, but the unfolding transition of mutant HgammaS-crystallin shows an intermediate state. The first transition (N --> I) shows a [GuHCl](1/2) of 0.5 M while the second transition (I --> U) has the same [GuHCl](1/2) as wild-type HgammaS-crystallin, about 2.0 M. Our present study confirms the high stability of wild-type HgammaS-crystallin and demonstrates that the G18V mutation destabilizes the protein toward heat and GuHCl-induced unfolding. These biophysical characteristics are consistent with the progressive cataract formation seen in the family members carrying this mutation. JF - Biochemistry AU - Ma, Zhiwei AU - Piszczek, Grzegorz AU - Wingfield, Paul T AU - Sergeev, Yuri V AU - Hejtmancik, J Fielding AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/08/04/ PY - 2009 DA - 2009 Aug 04 SP - 7334 EP - 7341 VL - 48 IS - 30 KW - gamma-Crystallins KW - 0 KW - CRYGS protein, human KW - 148467-57-6 KW - Guanidine KW - JU58VJ6Y3B KW - Index Medicus KW - Hot Temperature KW - Guanidine -- metabolism KW - Guanidine -- chemistry KW - Thermodynamics KW - Spectrometry, Fluorescence KW - Lens, Crystalline -- pathology KW - Lens, Crystalline -- metabolism KW - Humans KW - Protein Folding KW - Protein Denaturation KW - Circular Dichroism KW - Lens, Crystalline -- chemistry KW - Cataract -- metabolism KW - gamma-Crystallins -- chemistry KW - gamma-Crystallins -- metabolism KW - Point Mutation KW - Cataract -- genetics KW - gamma-Crystallins -- genetics KW - Protein Conformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67617022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+G18V+CRYGS+mutation+associated+with+human+cataracts+increases+gammaS-crystallin+sensitivity+to+thermal+and+chemical+stress.&rft.au=Ma%2C+Zhiwei%3BPiszczek%2C+Grzegorz%3BWingfield%2C+Paul+T%3BSergeev%2C+Yuri+V%3BHejtmancik%2C+J+Fielding&rft.aulast=Ma&rft.aufirst=Zhiwei&rft.date=2009-08-04&rft.volume=48&rft.issue=30&rft.spage=7334&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi900467a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):1993-8 [10688888] Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14485-90 [15452352] J Biochem Biophys Methods. 2000 Aug 10;45(1):1-21 [10899387] Biophys Chem. 2000 Aug 30;86(2-3):95-108 [11026675] Br J Ophthalmol. 2000 Dec;84(12):1376-9 [11090476] Anal Biochem. 2000 Dec 15;287(2):243-51 [11112270] Anal Biochem. 2000 Dec 15;287(2):252-60 [11112271] Invest Ophthalmol Vis Sci. 2001 Mar;42(3):601-5 [11222516] Invest Ophthalmol Vis Sci. 2002 Jan;43(1):205-15 [11773033] Protein Sci. 2003 Mar;12(3):480-90 [12592018] J Med Genet. 2003 Nov;40(11):e124 [14627691] Arch Ophthalmol. 2004 Apr;122(4):525-30 [15078670] Prog Biophys Mol Biol. 2004 Nov;86(3):407-85 [15302206] Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3608-19 [15452068] Nature. 1981 Feb 26;289(5800):771-7 [7464942] Methods Enzymol. 1986;131:266-80 [3773761] Prog Biophys Mol Biol. 1988;51(1):47-76 [3064189] Trends Biotechnol. 1994 May;12(5):193-8 [7764903] Invest Ophthalmol Vis Sci. 1995 Jan;36(1):227-35 [7822150] Protein Sci. 1994 Oct;3(10):1840-6 [7849599] Protein Sci. 1994 Nov;3(11):1927-37 [7703839] Mol Vis. 1998 Apr 30;4:8 [9565648] Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1008-12 [9927684] Protein Sci. 2005 Aug;14(8):2030-43 [16046626] J Med Genet. 2005 Sep;42(9):706-10 [16141006] Curr Biol. 2005 Sep 20;15(18):1684-9 [16169492] Mol Vis. 2005;11:758-63 [16179907] Protein Sci. 2005 Dec;14(12):3101-14 [16260758] Arch Ophthalmol. 2007 Feb;125(2):165-73 [17296892] Protein Sci. 2007 Nov;16(11):2427-44 [17905830] Mol Vis. 2008;14:1157-70 [18587492] Mol Vis. 2009;15:476-81 [19262743] Am J Hum Genet. 2000 Apr;66(4):1426-31 [10729115] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bi900467a ER - TY - JOUR T1 - Height and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial AN - 20958879; 10988345 AB - Background:The relationship between prostate cancer and height is uncertain. Methods:We prospectively examined the association of height with prostate cancer among 34268 men in the prostate, lung, colorectal, and ovarian cancer trial. Anthropometry was assessed at baseline and 2144 incident prostate cancer cases were identified upto 8.9 years of follow-up. Results:Overall, tallness was not associated with the risk of prostate cancer or with the risk of non-aggressive disease, but the risk for aggressive prostate cancer tended to be greater in taller men (Gleason score greater than or equal to 7 or stage greater than or equal to III; P trend=0.05; relative risk (RR) for 190cm+ vs less than or equal to 170cm=1.39, 95% confidence interval (95% CI): 0.96-2.01). This association was largely limited to men below the age of 65 years (P trend=0.008; RR for 190cm+ vs less than or equal to 170cm=1.76, 95% CI: 1.06-2.93; P for interaction=0.009), although the number of cases was small and risk estimates were somewhat unstable. Conclusion:The results of this large prospective prostate cancer screening trial suggest that tallness is associated with increased risk for younger onset aggressive prostate cancer.British Journal of Cancer (2009) 101, 522-525; doi:10.1038/sj.bjc.6605159 www.bjcancer.com Published online 30 June 2009 JF - British Journal of Cancer AU - Ahn, J AU - Moore, S C AU - Albanes, D AU - Huang, W-Y AU - Leitzmann, M F AU - Hayes, R B AD - [1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA [2] Division of Epidemiology, New York University School of Medicine, New York, NY 10016, USA Y1 - 2009/08/04/ PY - 2009 DA - 2009 Aug 04 SP - 522 EP - 525 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 3 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - Lung KW - ovarian carcinoma KW - prostate cancer KW - Cancer KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20958879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Height+and+risk+of+prostate+cancer+in+the+prostate%2C+lung%2C+colorectal%2C+and+ovarian+cancer+screening+trial&rft.au=Ahn%2C+J%3BMoore%2C+S+C%3BAlbanes%2C+D%3BHuang%2C+W-Y%3BLeitzmann%2C+M+F%3BHayes%2C+R+B&rft.aulast=Ahn&rft.aufirst=J&rft.date=2009-08-04&rft.volume=101&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605159 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Lung; ovarian carcinoma; prostate cancer; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605159 ER - TY - JOUR T1 - Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human AN - 20629702; 9372235 AB - Parathyroid hormone receptor 2 (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39) constitute a neuromodulator system implicated in endocrine and nociceptive regulation. We now describe the presence and distribution of the PTH2R and TIP39 in the brain of primates using a range of tissues and ages from macaque and human brain. In situ hybridization histochemistry of TIP39 mRNA, studied in young macaque brain, due to its possible decline beyond late postnatal ages, was present only in the thalamic subparafascicular area and the pontine medial paralemniscal nucleus. In contrast, in situ hybridization histochemistry in macaque identified high levels of PTH2R expression in the central amygdaloid nucleus, medial preoptic area, hypothalamic paraventricular and periventricular nuclei, medial geniculate, and the pontine tegmentum. PTH2R mRNA was also detected in several human brain areas by RT-PCR. The distribution of PTH2R-immunoreactive fibers in human, determined by immunocytochemistry, was similar to that in rodents, including dense fiber networks in the medial preoptic area, hypothalamic paraventricular, periventricular and infundibular (arcuate) nuclei, lateral hypothalamic area, median eminence, thalamic paraventricular nucleus, periaqueductal gray, lateral parabrachial nucleus, nucleus of the solitary tract, sensory trigeminal nuclei, medullary dorsal reticular nucleus, and dorsal horn of the spinal cord. Co-localization suggested that PTH2R fibers are glutamatergic, and that TIP39 may directly influence hypophysiotropic somatostatin containing and indirectly influence corticotropin releasing-hormone containing neurons. The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception. JF - Neuroscience AU - Bago, A G AU - Dimitrov, E AU - Saunders, R AU - Seress, L AU - Palkovits, M AU - Usdin, T B AU - Dobolyi, A AD - National Institute of Mental Health, Building 35/Room 1B-215, 35 Convent Drive, MSC 3728, Bethesda, MD 20892-3728, USA, usdint@mail.nih.gov Y1 - 2009/08/04/ PY - 2009 DA - 2009 Aug 04 SP - 128 EP - 147 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 162 IS - 1 SN - 0306-4522, 0306-4522 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Immunocytochemistry KW - Hypothalamus KW - Age KW - Anxiety KW - Spinal cord KW - Fear KW - Reproductive behavior KW - Thalamus KW - Paraventricular nucleus KW - Pituitary hormones KW - parabrachial nucleus KW - Neuromodulation KW - Nervous system KW - Glutamatergic transmission KW - Tegmentum KW - Parathyroid hormone KW - Polymerase chain reaction KW - Hypothalamus (lateral) KW - Solitary tract nucleus KW - Periaqueductal gray area KW - Macaca KW - Brain KW - Preoptic area KW - Pain perception KW - Primates KW - Somatostatin KW - mRNA KW - Fibers KW - Dorsal horn KW - Neurons KW - Parathyroid hormone receptors KW - Histochemistry KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Parathyroid+hormone+2+receptor+and+its+endogenous+ligand+tuberoinfundibular+peptide+of+39+residues+are+concentrated+in+endocrine%2C+viscerosensory+and+auditory+brain+regions+in+macaque+and+human&rft.au=Bago%2C+A+G%3BDimitrov%2C+E%3BSaunders%2C+R%3BSeress%2C+L%3BPalkovits%2C+M%3BUsdin%2C+T+B%3BDobolyi%2C+A&rft.aulast=Bago&rft.aufirst=A&rft.date=2009-08-04&rft.volume=162&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.04.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Immunocytochemistry; Age; Hypothalamus; Anxiety; Fear; Spinal cord; Reproductive behavior; Thalamus; Pituitary hormones; Paraventricular nucleus; parabrachial nucleus; Glutamatergic transmission; Nervous system; Neuromodulation; Tegmentum; Parathyroid hormone; Polymerase chain reaction; Hypothalamus (lateral); Solitary tract nucleus; Periaqueductal gray area; Pain perception; Preoptic area; Brain; Somatostatin; mRNA; Fibers; Dorsal horn; Neurons; Parathyroid hormone receptors; Histochemistry; Macaca; Primates DO - http://dx.doi.org/10.1016/j.neuroscience.2009.04.054 ER - TY - JOUR T1 - Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis AN - 20756025; 10238281 AB - Inorganic arsenic is a known human skin carcinogen. Chronic arsenic exposure results in various human skin lesions, including hyperkeratosis and squamous cell carcinoma (SCC), both characterized by distorted cytokeratin (CK) production. Prior work shows the human skin keratinocyte HaCaT cell line, when exposed chronically for >25 weeks to a low level of inorganic arsenite (100nM) results in cells able to produce aggressive SCC upon inoculation into nude mice. In the present study, CK expression analysis was performed in arsenic-exposed HaCaT cells during the progressive acquisition of this malignant phenotype (0-20 weeks) to further validate this model as relevant to epidermal carcinogenesis induced by arsenic in humans. Indeed, we observed clear evidence of acquired cancer phenotype by 20 weeks of arsenite exposure including the formation of giant cells, a >4-fold increase in colony formation in soft agar and a 2.5-fold increase in matrix metalloproteinase-9 secretion, an enzyme often secreted by cancer cells to help invade through the local extra-cellular matrix. During this acquired malignant phenotype, various CK genes showed markedly altered expression at the transcript and protein levels in a time-dependent manner. For example, CK1, a marker of hyperkeratosis, increased up to 34-fold during arsenic-induced transformation, while CK13, a marker for dermal cancer progression, increased up to 45-fold. The stem cell marker, CK15, increased up to 7-fold, particularly during the later stages of arsenic exposure, indicating a potential emergence of cancer stem-like cells with arsenic-induced acquired malignant phenotype. The expression of involucrin and loricrin, markers for keratinocyte differentiation, increased up to 9-fold. Thus, during arsenic-induced acquired cancer phenotype in human keratinocytes, dramatic and dynamic alterations in CK expression occur which are consistent with the process of epidermal carcinogenesis helping validate this as an appropriate model for the study of arsenic-induced skin cancer. JF - Toxicology AU - Sun, Y AU - Pi, J AU - Wang, X AU - Tokar, E J AU - Liu, J AU - Waalkes, M P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA, waalkes@niehs.nih.gov Y1 - 2009/08/03/ PY - 2009 DA - 2009 Aug 03 SP - 162 EP - 170 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 262 IS - 2 SN - 0300-483X, 0300-483X KW - Environment Abstracts; Toxicology Abstracts KW - Transformation KW - Agar KW - Secretion KW - Animal models KW - Skin cancer KW - Carcinogens KW - Differentiation KW - Stem cells KW - Colonies KW - Lesions KW - Keratinocytes KW - Cytokeratin KW - Giant cells KW - Arsenic KW - Skin KW - Arsenite KW - Enzymes KW - Transcription KW - squamous cell carcinoma KW - Cancer KW - Skin diseases KW - stem cells KW - Carcinogenesis KW - Inoculation KW - Proteins KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Aberrant+cytokeratin+expression+during+arsenic-induced+acquired+malignant+phenotype+in+human+HaCaT+keratinocytes+consistent+with+epidermal+carcinogenesis&rft.au=Sun%2C+Y%3BPi%2C+J%3BWang%2C+X%3BTokar%2C+E+J%3BLiu%2C+J%3BWaalkes%2C+M+P&rft.aulast=Sun&rft.aufirst=Y&rft.date=2009-08-03&rft.volume=262&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2009.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Giant cells; Agar; Arsenic; Secretion; Animal models; Arsenite; Skin cancer; Transcription; Enzymes; squamous cell carcinoma; Carcinogens; Differentiation; Colonies; Stem cells; Skin diseases; Carcinogenesis; Inoculation; Keratinocytes; Cytokeratin; Skin; stem cells; Proteins; Lesions; Cancer DO - http://dx.doi.org/10.1016/j.tox.2009.06.003 ER - TY - CPAPER T1 - Lipoproteins, VEGFR-1, and angiogenesis T2 - 2009 Gordon Research Conference on Angiogenesis AN - 40423187; 5301451 JF - 2009 Gordon Research Conference on Angiogenesis AU - Weinstein, Brant Y1 - 2009/08/02/ PY - 2009 DA - 2009 Aug 02 KW - Vascular endothelial growth factor receptors KW - Lipoproteins KW - Angiogenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40423187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Angiogenesis&rft.atitle=Lipoproteins%2C+VEGFR-1%2C+and+angiogenesis&rft.au=Weinstein%2C+Brant&rft.aulast=Weinstein&rft.aufirst=Brant&rft.date=2009-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Angiogenesis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=angiogen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Meiotic Homologous Recombination and Pairing in Mice T2 - Genetic Recombination and Genome Rearrangements AN - 40407601; 5301107 JF - Genetic Recombination and Genome Rearrangements AU - Camerini-Otero, Dan Y1 - 2009/08/02/ PY - 2009 DA - 2009 Aug 02 KW - Mice KW - Homologous recombination KW - Meiosis KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40407601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Genetic+Recombination+and+Genome+Rearrangements&rft.atitle=Meiotic+Homologous+Recombination+and+Pairing+in+Mice&rft.au=Camerini-Otero%2C+Dan&rft.aulast=Camerini-Otero&rft.aufirst=Dan&rft.date=2009-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genetic+Recombination+and+Genome+Rearrangements&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11708.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of joint molecule resolution T2 - Genetic Recombination and Genome Rearrangements AN - 40403883; 5301103 JF - Genetic Recombination and Genome Rearrangements AU - Lichten, Michael Y1 - 2009/08/02/ PY - 2009 DA - 2009 Aug 02 KW - Joints KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40403883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Genetic+Recombination+and+Genome+Rearrangements&rft.atitle=Control+of+joint+molecule+resolution&rft.au=Lichten%2C+Michael&rft.aulast=Lichten&rft.aufirst=Michael&rft.date=2009-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genetic+Recombination+and+Genome+Rearrangements&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11708.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incidental magnetization transfer contrast by fat saturation preparation pulses in multislice look-locker echo planar imaging AN - 883029093; 15255358 AB - In this study, it is demonstrated that fat saturation (FS) preparation (prep) pulses generate incidental magnetization transfer contrast (MTC) in multislice Look-Locker (LL) imaging. It is shown that frequency-selective FS prep pulses can invoke MTC through the exchange between free and motion-restricted protons. Simulation reveals that the fractional signal loss by these MTC effects is more severe for smaller flip angles (FAs), shorter repetition times (TRs), and greater number of slices (SN). These incidental MTC effects result in a signal attenuation at a steady state (up to 30%) and a T1 measurement bias (up to 20%) when using inversion recovery (IR) LL echo-planar imaging (EPI) sequences. Furthermore, it is shown that water-selective MRI using binomial pulses has the potential to minimize the signal attenuation and provide unbiased T1 measurement without fat artifacts in MR images. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Shin, Wanyong AU - Gu, Hong AU - Yang, Yihong Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 520 EP - 526 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 2 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Protons KW - Inversion KW - Fas antigen KW - Magnetic resonance imaging KW - CD95 antigen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883029093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Incidental+magnetization+transfer+contrast+by+fat+saturation+preparation+pulses+in+multislice+look-locker+echo+planar+imaging&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2009-08-01&rft.volume=62&rft.issue=2&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22034 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22034/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Repetition; Fas antigen; Inversion; Protons; Magnetic resonance imaging; CD95 antigen DO - http://dx.doi.org/10.1002/mrm.22034 ER - TY - JOUR T1 - Profile order and time-dependent artifacts in contrast-enhanced coronary MR angiography at 3T: Origin and prevention AN - 883027171; 15255335 AB - To enhance the clinical value of coronary magnetic resonance angiography (MRA), high-relaxivity contrast agents have recently been used at 3T. Here we examine a uniform bilateral shadowing artifact observed along the coronary arteries in MRA images collected using such a contrast agent. Simulations were performed to characterize this artifact, including its origin, to determine how best to mitigate this effect, and to optimize a data acquisition/injection scheme. An intraluminal contrast agent concentration model was used to simulate various acquisition strategies with two profile orders for a slow-infusion of a high-relaxivity contrast agent. Filtering effects from temporally variable weighting in k-space are prominent when a centric, radial (CR) profile order is applied during contrast infusion, resulting in decreased signal enhancement and underestimation of vessel width, while both pre- and postinfusion steady-state acquisitions result in overestimation of the vessel width. Acquisition during the brief postinfusion steady-state produces the greatest signal enhancement and minimizes k-space filtering artifacts. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Kotys, Melanie S AU - Herzka, Daniel A AU - Vonken, Evert-Jan AU - Ohayon, Jacques AU - Heroux, Julie AU - Gharib, Ahmed M AU - Stuber, Matthias AU - Pettigrew, Roderic I AD - National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA, rpettig@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 292 EP - 299 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 2 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Angiography KW - Contrast media KW - Data acquisition KW - Models KW - N.M.R. KW - coronary artery KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883027171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Profile+order+and+time-dependent+artifacts+in+contrast-enhanced+coronary+MR+angiography+at+3T%3A+Origin+and+prevention&rft.au=Kotys%2C+Melanie+S%3BHerzka%2C+Daniel+A%3BVonken%2C+Evert-Jan%3BOhayon%2C+Jacques%3BHeroux%2C+Julie%3BGharib%2C+Ahmed+M%3BStuber%2C+Matthias%3BPettigrew%2C+Roderic+I&rft.aulast=Kotys&rft.aufirst=Melanie&rft.date=2009-08-01&rft.volume=62&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.21997 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.21997/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Angiography; Contrast media; N.M.R.; Data acquisition; Models; coronary artery DO - http://dx.doi.org/10.1002/mrm.21997 ER - TY - JOUR T1 - Magnetic resonance elastography in the liver at 3 Tesla using a second harmonic approach AN - 883027165; 15255334 AB - Magnetic resonance elastography (MRE) using mechanical stimulation has demonstrated diagnostic value and clinical promise in breast, liver, and kidney at 1.5 Tesla (T). However, MRE at 1.5T suffers from long imaging times and would benefit from greater signal-to-noise for more robust postprocessing. We present an MRE sequence modified for liver imaging at 3.0T. To avoid artifacts in the phase images, the sequence maintains a short TE by using a second harmonic approach, including stronger motion encoding gradients, shorter radio frequency pulses and an echo-planar readout. Scan time was decreased by a factor of ~2 relative to 1.5T by using an EPI readout and a higher density sampling of the phase waveform was used to calculate shear stiffness and viscosity. Localized (small region of interest) and global (whole-liver region of interest) measurements in normal healthy subjects compared very favorably with previously published results at 1.5T. There was no significant difference between global and localized measures. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Herzka, D A AU - Sinkus, R AU - Pettigrew, R I AU - Gharib, A M AD - National Heart, Lung and Blood Institute, NIH, DHHS, Bethesda, Maryland, daniel.herzka@gmail.com Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 284 EP - 291 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 2 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Viscosity KW - Liver KW - Kidney KW - Image processing KW - N.M.R. KW - Sampling KW - Mechanical stimuli KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883027165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Magnetic+resonance+elastography+in+the+liver+at+3+Tesla+using+a+second+harmonic+approach&rft.au=Herzka%2C+D+A%3BSinkus%2C+R%3BPettigrew%2C+R+I%3BGharib%2C+A+M&rft.aulast=Herzka&rft.aufirst=D&rft.date=2009-08-01&rft.volume=62&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.21956 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.21956/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Viscosity; Kidney; Liver; Image processing; N.M.R.; Sampling; Mechanical stimuli DO - http://dx.doi.org/10.1002/mrm.21956 ER - TY - JOUR T1 - Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex AN - 754558607; 13335935 AB - MRI at 7 Tesla has been used to investigate the accumulation of manganese in the occipital cortex of common marmoset monkeys (Callithrix jacchus) after administering four fractionated injections of 30 mg/kg MnCl2 . 4H2O in the tail vein. We found a statistically significant decrease in T1 in the primary (V1) and secondary (V2) areas of the visual cortex caused by an accumulation of manganese. The larger T1 shortening in V1 (T1 = 640 ms) relative to V2 (T1 = 490 ms) allowed us to robustly detect the V1/V2 border in vivo using heavily T1-weighted MRI. Furthermore, the dorso-medial (DM) and middle-temporal (MT) areas of the visual pathway could be identified by their T1-weighted enhancement. We showed by comparison to histological sections stained for cytochrome oxidase (CO) activity that the extent of V1 is accurately identified throughout the visual cortex by manganese-enhanced MRI (MEMRI). This provides a means of visualizing functional cortical regions in vivo and could be used in longitudinal studies of phenomena such as cortical plasticity, and for non-destructive localization of cortical regions to guide in the implementation of functional techniques. Published in 2009 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Bock, Nicholas A AU - Kocharyan, Ara AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health 10 Center Drive, Building 10, Room BD109 Bethesda, MD 20892-1065, USA, bockn@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 730 EP - 736 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 22 IS - 7 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Callithrix jacchus KW - Magnetic resonance imaging KW - Plasticity (cortical) KW - Cortex (occipital) KW - Statistical analysis KW - Cytochrome-c oxidase KW - Primates KW - Visual pathways KW - Veins KW - Cortex (visual) KW - N.M.R. KW - Manganese KW - Plasticity (functional) KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754558607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Manganese-enhanced+MRI+visualizes+V1+in+the+non-human+primate+visual+cortex&rft.au=Bock%2C+Nicholas+A%3BKocharyan%2C+Ara%3BSilva%2C+Afonso+C&rft.aulast=Bock&rft.aufirst=Nicholas&rft.date=2009-08-01&rft.volume=22&rft.issue=7&rft.spage=730&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1384 L2 - http://www3.interscience.wiley.com/journal/122276533/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Visual pathways; Veins; Cortex (visual); Cortex (occipital); Plasticity (cortical); Magnetic resonance imaging; Statistical analysis; N.M.R.; Cytochrome-c oxidase; Manganese; Plasticity (functional); Callithrix jacchus; Primates DO - http://dx.doi.org/10.1002/nbm.1384 ER - TY - JOUR T1 - A multivariate hypothesis testing framework for tissue clustering and classification of DTI data AN - 754557700; 13335934 AB - The primary aim of this work is to propose and investigate the effectiveness of a novel unsupervised tissue clustering and classification algorithm for diffusion tensor MRI (DTI) data. The proposed algorithm utilizes information about the degree of homogeneity of the distribution of diffusion tensors within voxels. We adapt frameworks proposed by Hext and Snedecor, where the null hypothesis of diffusion tensors belonging to the same distribution is assessed by an F-test. Tissue type is classified according to one of the four possible diffusion models, the assignment of which is determined by a parsimonious model selection framework based on Schwarz Criterion. Both numerical phantoms and diffusion-weighted imaging (DWI) data obtained from excised rat and pig spinal cords are used to test and validate these tissue clustering and classification approaches. The unsupervised clustering method effectively identifies distinct regions of interest (ROIs) in phantoms and real experimental DTI data. JF - NMR in Biomedicine AU - Freidlin, Raisa Z AU - Ozarslan, Evren AU - Assaf, Yaniv AU - Komlosh, Michal E AU - Basser, Peter J AD - Biomedical Imaging and Visualization Section, Computational Bioscience and Engineering Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA, raisa@helix.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 716 EP - 729 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 22 IS - 7 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Classification KW - Spinal cord KW - Information processing KW - Magnetic resonance imaging KW - Animal models KW - Algorithms KW - Diffusion KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754557700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=A+multivariate+hypothesis+testing+framework+for+tissue+clustering+and+classification+of+DTI+data&rft.au=Freidlin%2C+Raisa+Z%3BOzarslan%2C+Evren%3BAssaf%2C+Yaniv%3BKomlosh%2C+Michal+E%3BBasser%2C+Peter+J&rft.aulast=Freidlin&rft.aufirst=Raisa&rft.date=2009-08-01&rft.volume=22&rft.issue=7&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1383 L2 - http://www3.interscience.wiley.com/journal/122508690/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Classification; Spinal cord; Information processing; Magnetic resonance imaging; Algorithms; Animal models; N.M.R.; Diffusion DO - http://dx.doi.org/10.1002/nbm.1383 ER - TY - JOUR T1 - Points to Consider on the Statistical Analysis of Rodent Cancer Bioassay Data When Incorporating Historical Control Data AN - 746197626; 12621261 AB - Researchers routinely use historical control data (HCD) when analyzing rodent carcinogenicity data obtained in a particular study. Although the concurrent control group is considered to be the most relevant group to compare with the dose groups, the HCD provides a broader perspective to assist in understanding the significance of the current study. The HCD is used to provide information about the incidences of spontaneous tumors and malignant systemic disorders such as lymphoma and leukemia. This article presents some possible ways of incorporating the HCD when analyzing data from a rodent cancer bioassay. Specifically, exploratory (informal) and formal statistical procedures for analyzing such data are reviewed. The boxplot is presented as an exploratory tool that describes the current data in the context of the distribution of the HCD. It will also identify potential outliers that would not be otherwise be flagged using standard methods such as the mean, standard deviation, and range. The various options for the statistical analysis of HCD presented here do not necessarily represent standard practice. JF - Toxicologic Pathology AU - Elmore, Susan A AU - Peddada, Shyamal D AD - National Toxicology Program, Research Triangle Park, North Carolina 27709, USA,, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA, elmore@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 672 EP - 676 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Leukemia KW - Data processing KW - Statistics KW - Standard deviation KW - Carcinogenicity KW - Reviews KW - Statistical analysis KW - Tumors KW - Lymphoma KW - Cancer KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746197626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Points+to+Consider+on+the+Statistical+Analysis+of+Rodent+Cancer+Bioassay+Data+When+Incorporating+Historical+Control+Data&rft.au=Elmore%2C+Susan+A%3BPeddada%2C+Shyamal+D&rft.aulast=Elmore&rft.aufirst=Susan&rft.date=2009-08-01&rft.volume=37&rft.issue=5&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309339606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Leukemia; Standard deviation; Statistics; Data processing; Carcinogenicity; Reviews; Statistical analysis; Tumors; Lymphoma; Cancer DO - http://dx.doi.org/10.1177/0192623309339606 ER - TY - JOUR T1 - Prevalence, Serotype, and Antimicrobial Resistance of Salmonella on Broiler Carcasses Postpick and Postchill in 20 U.S. Processing Plants AN - 745977921; 12685719 AB - The objective of this study was to measure the effect of broiler processing on the prevalence, serotype, and antimicrobial resistance profiles of salmonellae. Twenty U.S. commercial processing plants representing eight integrators in 13 states were included in the survey. In each of four replications, 10 carcasses from one flock were collected at rehang and 10 more carcasses were collected at postchill; each carcass was sampled by whole-carcass rinse. Salmonella organisms were isolated from carcass rinses by standard cultural techniques, serotypes were determined, and the resistance to 15 antimicrobials was measured. Overall, Salmonella was detected on 72% of carcasses at rehang (ranging from 35 to 97%) and on 20% of carcasses postchill (ranging from 2.5 to 60%). In every instance, a significant (P < 0.05) decrease in Salmonella prevalence was noted between rehang and postchill. The four most common serotypes, accounting for 64% of all Salmonella isolates, were Kentucky, Heidelberg, Typhimurium, and Typhimurium var. 5-; most isolates of Kentucky (52%), Heidelberg (79%), and Typhimurium (54%) serotypes were susceptible to all antimicrobial drugs tested. However, only 15% of the Typhimurium var. 5- isolates were pansusceptible; more than one-half of the isolates of this serotype were resistant to three or more drugs. No isolate of any serotype exhibited resistance to amikacin, ceftriaxone, ciprofloxacin, or trimethoprim-sulfamethoxazole. These data demonstrate that although processing lessens carcass contamination with Salmonella, antimicrobial-resistant isolates may still be present. JF - Journal of Food Protection AU - Berrang, M E AU - Bailey, J S AU - Altekruse, S F AU - Shaw JR, W K AU - Patel, B L AU - Meinersmann, R J AU - Fedorka-Cray, P J AD - U.S. Department of Agriculture, Agricultural Research Service, Russell Research Center, Athens, Georgia 30605; and 2US. Department of Agriculture, Food Safety and Inspection Service, Washington, DC 20250-3700, USAMS 09-084: Received 23 February 2009/Accepted 28 March 2009* Author for correspondence. Tel: 706-546-3551; Fax: 706-546-3633; mark.berrang[AT]ars.usda.gov. Present address: bioMerieux Inc., Hazelwood, MO 63042, USA. Present address: National Cancer Institute, Rockville, MD 20892, USA. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1610 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 72 IS - 8 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Data processing KW - Amikacin KW - Replication KW - Drug resistance KW - trimethoprim-sulfamethoxazole KW - Ceftriaxone KW - Food contamination KW - Food plants KW - Antimicrobial agents KW - Ciprofloxacin KW - Carcasses KW - Salmonella KW - A 01330:Food Microbiology KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745977921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Prevalence%2C+Serotype%2C+and+Antimicrobial+Resistance+of+Salmonella+on+Broiler+Carcasses+Postpick+and+Postchill+in+20+U.S.+Processing+Plants&rft.au=Berrang%2C+M+E%3BBailey%2C+J+S%3BAltekruse%2C+S+F%3BShaw+JR%2C+W+K%3BPatel%2C+B+L%3BMeinersmann%2C+R+J%3BFedorka-Cray%2C+P+J&rft.aulast=Berrang&rft.aufirst=M&rft.date=2009-08-01&rft.volume=72&rft.issue=8&rft.spage=1610&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 25 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Ciprofloxacin; Data processing; Serotypes; Carcasses; Amikacin; Replication; Drug resistance; trimethoprim-sulfamethoxazole; Ceftriaxone; Food plants; Food contamination; Antimicrobial agents; Salmonella ER - TY - JOUR T1 - High-temperature beverages and foods and esophageal cancer risk - A systematic review AN - 745642051; 13163002 AB - Coffee, tea and mate may cause esophageal cancer (EC) by causing thermal injury to the esophageal mucosa. If so, the risk of EC attributable to thermal injury could be large in populations in which these beverages are commonly consumed. In addition, these drinks may cause or prevent EC via their chemical constituents. Therefore, a large number of epidemiologic studies have investigated the association of an indicator of amount or temperature of use of these drinks or other hot foods and beverages with risk of EC. We conducted a systematic review of these studies and report the results for amount and temperature of use separately. By searching PubMed and the ISI, we found 59 eligible studies. For coffee and tea, there was little evidence for an association between amount of use and EC risk; however, the majority of studies showed an increased risk of EC associated with higher drinking temperature which was statistically significant in most of them. For mate drinking, the number of studies was limited, but they consistently showed that EC risk increased with both amount consumed and temperature, and these 2 were independent risk factors. For other hot foods and drinks, over half of the studies showed statistically significant increased risks of EC associated with higher temperature of intake. Overall, the available results strongly suggest that high-temperature beverage drinking increases the risk of EC. Future studies will require standardized strategies that allow for combining data and results should be reported by histological subtypes of EC. JF - International Journal of Cancer AU - Islami, Farhad AU - Boffetta, Paolo AU - Ren, Jian-Song AU - Pedoeim, Leah AU - Khatib, Dara AU - Kamangar, Farin AD - Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran, kamangaf@mail.nih.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 491 EP - 524 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 3 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Reviews KW - coffee KW - Temperature KW - Standards KW - tea KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=High-temperature+beverages+and+foods+and+esophageal+cancer+risk+-+A+systematic+review&rft.au=Islami%2C+Farhad%3BBoffetta%2C+Paolo%3BRen%2C+Jian-Song%3BPedoeim%2C+Leah%3BKhatib%2C+Dara%3BKamangar%2C+Farin&rft.aulast=Islami&rft.aufirst=Farhad&rft.date=2009-08-01&rft.volume=125&rft.issue=3&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24445 L2 - http://www3.interscience.wiley.com/journal/122275334/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Injuries; Reviews; coffee; Temperature; Standards; tea; Cancer DO - http://dx.doi.org/10.1002/ijc.24445 ER - TY - JOUR T1 - Morphological deformities as biomarkers in fish from contaminated rivers in Taiwan. AN - 734042299; 19742162 AB - Tilapia (Oreochromis spp.) were collected seasonally from four contaminated rivers in southwestern Taiwan for studies of morphological deformities that could be used as biomarkers of contamination. Morphological deformities found in tilapia were separated into 15 categories. Overall, the prevalence of deformities such as split fins, lower lip extension and gill deformities were significantly related to various water quality parameters, including low DO and high ammonium, lead and zinc concentrations. The persistence of tilapia in polluted waters and the development of a suite of morphological deformities suggest that tilapia can be used as sentinels of non-point source pollution in rivers. JF - International journal of environmental research and public health AU - Sun, Peter Lin AU - Hawkins, William E AU - Overstreet, Robin M AU - Brown-Peterson, Nancy J AD - Department of Aquaculture, National Pingtung University of Science and Technology, Nei Pu, Pingtung, Taiwan. plsun@mail.npust.edu.tw Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 2307 EP - 2331 VL - 6 IS - 8 KW - Biomarkers KW - 0 KW - Index Medicus KW - indicator KW - morphological deformity KW - biomarker KW - river pollution KW - tilapia KW - Rivers KW - Animals KW - Taiwan KW - Seasons KW - Water Pollution -- analysis KW - Environmental Monitoring KW - Tilapia -- abnormalities KW - Water Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734042299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Morphological+deformities+as+biomarkers+in+fish+from+contaminated+rivers+in+Taiwan.&rft.au=Sun%2C+Peter+Lin%3BHawkins%2C+William+E%3BOverstreet%2C+Robin+M%3BBrown-Peterson%2C+Nancy+J&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2009-08-01&rft.volume=6&rft.issue=8&rft.spage=2307&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/10.3390%2Fijerph6082307 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-07 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Environ Manage. 2001 Jan;61(1):61-76 [11381459] Chemosphere. 2004 Mar;54(11):1613-8 [14675840] Bull Environ Contam Toxicol. 1995 Jan;54(1):60-7 [7756786] Chemosphere. 1995 Aug;31(3):2863-72 [7648210] Parassitologia. 1997 Sep;39(3):169-75 [9802064] Tissue Cell. 1998 Dec;30(6):617-26 [10189321] Mutat Res. 2009 Jan-Feb;681(1):80-92 [18439870] Environ Pollut. 2005 May;135(2):221-33 [15734582] Ecotoxicol Environ Saf. 2008 Jul;70(3):411-21 [17920119] Sci Total Environ. 2008 Jul 25;399(1-3):186-92 [18468656] Food Chem Toxicol. 2008 Jul;46(7):2440-4 [18468759] Sci Total Environ. 2008 Sep 15;403(1-3):215-21 [18619650] Ecotoxicol Environ Saf. 2009 Feb;72(2):496-506 [18243309] Mar Pollut Bull. 2004 Dec;49(11-12):986-98 [15556185] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3390/ijerph6082307 ER - TY - JOUR T1 - Trabectedin. AN - 734018884; 19684073 JF - The oncologist AU - Chuk, Meredith K AU - Balis, Frank M AU - Fox, Elizabeth AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. chukme@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 794 EP - 799 VL - 14 IS - 8 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Dioxoles KW - Tetrahydroisoquinolines KW - trabectedin KW - ID0YZQ2TCP KW - Index Medicus KW - Humans KW - Tetrahydroisoquinolines -- therapeutic use KW - Tetrahydroisoquinolines -- adverse effects KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Dioxoles -- adverse effects KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Tetrahydroisoquinolines -- pharmacology KW - Antineoplastic Agents, Alkylating -- adverse effects KW - Dioxoles -- therapeutic use KW - Dioxoles -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734018884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Trabectedin.&rft.au=Chuk%2C+Meredith+K%3BBalis%2C+Frank+M%3BFox%2C+Elizabeth&rft.aulast=Chuk&rft.aufirst=Meredith&rft.date=2009-08-01&rft.volume=14&rft.issue=8&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2009-0104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Oncologist. 2009 Sep;14(9):949 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2009-0104 ER - TY - JOUR T1 - Sorafenib and sunitinib. AN - 734018395; 19648603 JF - The oncologist AU - Kim, AeRang AU - Balis, Frank M AU - Widemann, Brigitte C AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. kimaer@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 800 EP - 805 VL - 14 IS - 8 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Indoles KW - Phenylurea Compounds KW - Pyridines KW - Pyrroles KW - Niacinamide KW - 25X51I8RD4 KW - sorafenib KW - 9ZOQ3TZI87 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Drug Interactions KW - Humans KW - Niacinamide -- analogs & derivatives KW - Pyrroles -- adverse effects KW - Pyridines -- chemistry KW - Benzenesulfonates -- therapeutic use KW - Pyrroles -- pharmacokinetics KW - Pyridines -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Indoles -- adverse effects KW - Pyridines -- therapeutic use KW - Pyrroles -- therapeutic use KW - Pyrroles -- chemistry KW - Antineoplastic Agents -- adverse effects KW - Benzenesulfonates -- adverse effects KW - Indoles -- pharmacokinetics KW - Benzenesulfonates -- pharmacokinetics KW - Indoles -- therapeutic use KW - Benzenesulfonates -- chemistry KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Pyridines -- adverse effects KW - Indoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734018395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Sorafenib+and+sunitinib.&rft.au=Kim%2C+AeRang%3BBalis%2C+Frank+M%3BWidemann%2C+Brigitte+C&rft.aulast=Kim&rft.aufirst=AeRang&rft.date=2009-08-01&rft.volume=14&rft.issue=8&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2009-0088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Oncologist. 2009 Sep;14(9):949 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2009-0088 ER - TY - JOUR T1 - HPV vaccination in women over 25 years of age: Asian Cervical Cancer Prevention Advisory Board recommendations. AN - 67649436; 19751332 AB - Cervical cancer is the second most common cancer among women worldwide and is responsible for more than 270 000 deaths every year, the majority of which occur in Asia. The Asian Cervical Cancer Prevention Advisory Board (ACCPAB) was established in 2005 with a mission to raise awareness of the significant disease burden of cervical cancer in Asia and the strategies for its prevention. Persistent infection with oncogenic subtypes of human papillomavirus (HPV) is the necessary cause of cervical cancer. Vaccines against the two most carcinogenic subtypes of HPV (HPV 16 and 18) are available and have the potential to prevent cervical cancer in 70-80% of HPV- naïve women. HPV vaccines have been first licensed for use in girls and women aged 9-26 years. However, women over 25 years of age are also vulnerable to HPV infection and are likely to benefit from vaccination. Current evidence shows that even women previously infected with HPV who have subsequently cleared the infection can obtain complete protection against the HPV types contained in the vaccines. Therefore, vaccinating sexually active women aged over 25 years offers significant benefits and may be expected to decrease the incidence of cervical cancer. The ACCPAB advocates the adoption of preventive measures against HPV infection, including vaccination, with a view to protecting women of all ages from developing cervical cancer. JF - The journal of obstetrics and gynaecology research AU - Basu, Partha AU - Ngan, Hextan Yuen Sheung AU - Hseon, Tay Eng AU - Asian Cervical Cancer Prevention Advisory Board (ACCPAB) AD - Chittaranjan National Cancer Institute, Department of Gynaecologic Oncology, Kolkata, India. basupartha@hotmail.com ; Asian Cervical Cancer Prevention Advisory Board (ACCPAB) Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 712 EP - 716 VL - 35 IS - 4 SN - 1341-8076, 1341-8076 KW - Papillomavirus Vaccines KW - 0 KW - Index Medicus KW - Age Factors KW - Humans KW - Human papillomavirus 16 KW - Adult KW - Vaginal Smears KW - Human papillomavirus 18 KW - Middle Aged KW - Asia KW - Female KW - Uterine Cervical Neoplasms -- prevention & control KW - Papillomavirus Vaccines -- immunology KW - Cervical Intraepithelial Neoplasia -- prevention & control KW - Vaccination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67649436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+obstetrics+and+gynaecology+research&rft.atitle=HPV+vaccination+in+women+over+25+years+of+age%3A+Asian+Cervical+Cancer+Prevention+Advisory+Board+recommendations.&rft.au=Basu%2C+Partha%3BNgan%2C+Hextan+Yuen+Sheung%3BHseon%2C+Tay+Eng%3BAsian+Cervical+Cancer+Prevention+Advisory+Board+%28ACCPAB%29&rft.aulast=Basu&rft.aufirst=Partha&rft.date=2009-08-01&rft.volume=35&rft.issue=4&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+journal+of+obstetrics+and+gynaecology+research&rft.issn=13418076&rft_id=info:doi/10.1111%2Fj.1447-0756.2009.01022.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-16 N1 - Date created - 2009-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1447-0756.2009.01022.x ER - TY - JOUR T1 - Upper gastrointestinal bleeding from metastatic testicular cancer. AN - 67615138; 19715045 AB - We report a 22-year-old man who presented with a 2-week history of intermittent melena and worsening scrotal and leg swelling. His medical history was significant for testicular cancer for which he had undergone orchiectomy, lymphadenectomy, and platinum-based chemotherapy. Esophagogastroduodenoscopy (EGD) performed revealed polypoid mass lesions in the second and third portions of the duodenum. Biopsy revealed mixed germ cell tumor with immature teratoma, the same histology as his testicular cancer. His chemotherapy was changed to an ifosphamide-based regimen and a repeat upper endoscopic examination 5 months later revealed complete resolution of previously noted polypoid duodenal mass lesions. This also demonstrates the effectiveness of ifosphamide as second-line therapy in the setting of resistance to platinum-based therapy. JF - Journal of the National Medical Association AU - Laiyemo, Adeyinka O AU - Jack, Momodu AU - Dawkins, Fitzroy W AU - Smoot, Duane T AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Rm 3121, Bethesda, MD 20892-7354, USA. laiyemoa@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 808 EP - 809 VL - 101 IS - 8 SN - 1943-4693, 1943-4693 KW - Index Medicus KW - Humans KW - Adult KW - Biopsy KW - Endoscopy, Digestive System KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Testicular Neoplasms -- therapy KW - Gastrointestinal Hemorrhage -- etiology KW - Duodenal Neoplasms -- complications KW - Testicular Neoplasms -- pathology KW - Duodenal Neoplasms -- drug therapy KW - Duodenal Neoplasms -- diagnosis KW - Duodenal Neoplasms -- secondary KW - Testicular Neoplasms -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67615138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Medical+Association&rft.atitle=Upper+gastrointestinal+bleeding+from+metastatic+testicular+cancer.&rft.au=Laiyemo%2C+Adeyinka+O%3BJack%2C+Momodu%3BDawkins%2C+Fitzroy+W%3BSmoot%2C+Duane+T&rft.aulast=Laiyemo&rft.aufirst=Adeyinka&rft.date=2009-08-01&rft.volume=101&rft.issue=8&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Medical+Association&rft.issn=19434693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic risk and protective factors for the idiopathic inflammatory myopathies. AN - 67595677; 19691932 AB - The idiopathic inflammatory myopathies, or myositis syndromes, are heterogeneous autoimmune diseases defined by chronic muscle inflammation of unknown cause. They likely develop after the interaction of genetic and environmental risk factors in the absence of protective factors. The known genetic risk and protective factors are common alleles at polymorphic immune response loci and vary depending on phenotype. Furthermore, genetic associations are stronger with phenotypes defined by clinical features and autoantibodies than with myositis patients as a whole. Genetic factors for myositis also vary by age of onset, ethnicity, and environmental exposure group. Of interest, risk genes for one phenotype are often protective for another, possibly explaining the mutual exclusivity of many myositis subgroups. International collaborations using genome-wide association studies are needed to identify additional genes, gene-gene, and gene-environment interactions, all of which have pathogenic, therapeutic, and preventative implications for these increasingly recognized disorders. JF - Current rheumatology reports AU - O'Hanlon, Terrance P AU - Miller, Frederick W AD - National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA. ohanlont@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 287 EP - 294 VL - 11 IS - 4 KW - Autoantibodies KW - 0 KW - HLA Antigens KW - Index Medicus KW - Genetic Predisposition to Disease -- ethnology KW - Age Factors KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Humans KW - European Continental Ancestry Group KW - Environmental Exposure KW - African Americans KW - HLA Antigens -- genetics KW - Myositis -- genetics KW - Autoantibodies -- genetics KW - Myositis -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+rheumatology+reports&rft.atitle=Genetic+risk+and+protective+factors+for+the+idiopathic+inflammatory+myopathies.&rft.au=O%27Hanlon%2C+Terrance+P%3BMiller%2C+Frederick+W&rft.aulast=O%27Hanlon&rft.aufirst=Terrance&rft.date=2009-08-01&rft.volume=11&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Current+rheumatology+reports&rft.issn=1534-6307&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-04 N1 - Date created - 2009-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A personal perspective on the initial federal health-based regulation to remove lead from gasoline. AN - 67584355; 19672397 AB - This article describes the personal experience and perspective of the authors, who had primary responsibility for drafting the initial health-based regulation limiting lead content of gasoline during the early 1970s while employed by the U.S. Environmental Protection Agency (EPA). Information used by the U.S. EPA in developing the initial health-based regulation limiting lead content of gasoline in December 1973 and studies documenting the impact of that and subsequent actions. Among the lessons learned from this experience is the importance of having input from independent scientists to the regulatory decision-making process. This also demonstrates the critical role of independent peer-reviewed research, such as that supported by the National Institutes of Health, as well as research conducted by scientists from the Centers for Disease Control and Prevention, in delineating the consequences of lead exposure in the population. Removal of lead from gasoline in the United States has been described as one of the great public health achievements of the 20th century, but it almost did not happen. The experience of the authors in developing this regulation may be helpful to others involved in developing health-based regulatory policy in the future. The initial U.S. EPA health-based regulation to remove lead from gasoline is clearly an example where science successfully affected public policy. The leadership of the U.S. EPA at that time deserves much credit for establishing an atmosphere in which this was possible. JF - Environmental health perspectives AU - Bridbord, Kenneth AU - Hanson, David AD - Division of International Training and Research, Fogarty International Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-2220, USA. ken_bridbord@nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1195 EP - 1201 VL - 117 IS - 8 KW - Gasoline KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - gasoline KW - health-based regulation KW - lead KW - U.S. EPA KW - policy KW - government KW - United States KW - Lead Poisoning -- prevention & control KW - Humans KW - United States Environmental Protection Agency -- legislation & jurisprudence KW - Gasoline -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67584355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+personal+perspective+on+the+initial+federal+health-based+regulation+to+remove+lead+from+gasoline.&rft.au=Bridbord%2C+Kenneth%3BHanson%2C+David&rft.aulast=Bridbord&rft.aufirst=Kenneth&rft.date=2009-08-01&rft.volume=117&rft.issue=8&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0800534 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Res. 2000 Sep;84(1):20-35 [10991779] PLoS Med. 2008 May 27;5(5):e112 [18507499] N Engl J Med. 2003 Apr 17;348(16):1517-26 [12700371] Science. 1967 Oct 6;158(3797):132-4 [4228302] N Engl J Med. 1972 Mar 30;286(13):702-10 [4551386] N Engl J Med. 1973 Dec 13;289(24):1289-93 [4584189] N Engl J Med. 1973 Dec 6;289(23):1229-33 [4784897] N Engl J Med. 1975 Jan 16;292(3):123-9 [1196336] Environ Health Perspect. 1977 Aug;19:243-46 [71233] N Engl J Med. 1979 Mar 29;300(13):689-95 [763299] N Engl J Med. 1983 Jun 9;308(23):1373-7 [6188954] Am J Public Health. 1985 Apr;75(4):344-52 [2579591] N Engl J Med. 1990 Jan 11;322(2):83-8 [2294437] Science. 1992 Apr 24;256(5056):437-8 [1570504] Pediatrics. 1992 Dec;90(6):977-81 [1331947] Am J Public Health. 1995 Feb;85(2):165-6 [7856774] MMWR Morb Mortal Wkly Rep. 1997 Feb 21;46(7):141-6 [9072671] Environ Res. 1998 Aug;78(2):79-85 [9719611] Environ Health Perspect. 1998 Nov;106(11):745-50 [9799191] Am J Public Health. 1998 Dec;88(12):1871-7 [9842392] Arch Environ Health. 1965 Sep;11:344-60 [14334042] Environ Health Perspect. 2005 Jul;113(7):894-9 [16002379] Public Health Rep. 2005 May-Jun;120(3):330-7 [16134577] Neurotoxicology. 2006 Sep;27(5):693-701 [16889836] Environ Health Perspect. 2008 Feb;116(2):243-8 [18288325] PLoS Med. 2008 May 27;5(5):e101 [18507497] Public Health Rep. 2000 Nov-Dec;115(6):521-9 [11354334] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0800534 ER - TY - JOUR T1 - Environmental health research and the observer's dilemma. AN - 67584317; 19672396 AB - Environmental health researchers frequently study people in occupational, educational, recreational, or domestic settings who are exposed to hazardous agents. Deciding whether-and how-to inform research subjects about risks they face in their environment can be a challenging task for investigators. Because legal rules and professional guidelines do not cover this topic, investigators must carefully consider their ethical obligations in light of the facts and circumstances. To navigate through this dilemma, investigators should consider the evidence for the risks, the nature of the risks, the usefulness of risk information to the subjects, and the effects on the study and community of informing subjects about risks. JF - Environmental health perspectives AU - Resnik, David B AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. resnikd@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1191 EP - 1194 VL - 117 IS - 8 KW - Index Medicus KW - risk KW - human subjects KW - beneficence KW - observation KW - ethics KW - regulations KW - risk communication KW - environmental health research KW - Humans KW - Environmental Exposure KW - Risk Assessment KW - Disclosure -- ethics KW - Environmental Health -- ethics KW - Ethics, Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67584317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+health+research+and+the+observer%27s+dilemma.&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2009-08-01&rft.volume=117&rft.issue=8&rft.spage=1191&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900861 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioethics. 2008 May;22(4):209-17 [18405319] Environ Health Perspect. 2008 Apr;116(4):537-42 [18414640] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jul-Sep;26(3):237-55 [18781537] Environ Sci Technol. 2008 Nov 15;42(22):8252-9 [19068802] BMC Cancer. 2008;8:387 [19108730] Ann Allergy Asthma Immunol. 2009 Feb;102(2):125-30 [19230463] Am J Public Health. 2007 Mar;97(3):414-8 [17267718] J Med Ethics. 2007 Aug;33(8):481-6 [17664310] JAMA. 2000 May 24-31;283(20):2701-11 [10819955] Am J Bioeth. 2002 Spring;2(2):3-9 [12189059] Hastings Cent Rep. 2004 Jan-Feb;34(1):25-33 [15098404] Mil Med. 2005 Jun;170(6):505-9 [16001601] Nature. 2009 Mar 12;458(7235):148 [19279615] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900861 ER - TY - JOUR T1 - Short- and long-term effects of UV radiation on the pigmentation of human skin. AN - 67573623; 19675550 AB - The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32-35; doi:10.1038/jidsymp.2009.10. JF - The journal of investigative dermatology. Symposium proceedings AU - Coelho, Sergio G AU - Choi, Wonseon AU - Brenner, Michaela AU - Miyamura, Yoshinori AU - Yamaguchi, Yuji AU - Wolber, Rainer AU - Smuda, Christoph AU - Batzer, Jan AU - Kolbe, Ludger AU - Ito, Shosuke AU - Wakamatsu, Kazumasa AU - Zmudzka, Barbara Z AU - Beer, Janusz Z AU - Miller, Sharon A AU - Hearing, Vincent J AD - Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 32 EP - 35 VL - 14 IS - 1 KW - Melanins KW - 0 KW - Index Medicus KW - Melanocytes -- pathology KW - Skin -- radiation effects KW - Cell Count KW - Melanocytes -- metabolism KW - Skin -- metabolism KW - Humans KW - Skin -- pathology KW - Melanins -- metabolism KW - Dose-Response Relationship, Radiation KW - Melanocytes -- radiation effects KW - Time Factors KW - Immunohistochemistry KW - Skin Pigmentation -- radiation effects KW - Ultraviolet Rays -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67573623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.atitle=Short-+and+long-term+effects+of+UV+radiation+on+the+pigmentation+of+human+skin.&rft.au=Coelho%2C+Sergio+G%3BChoi%2C+Wonseon%3BBrenner%2C+Michaela%3BMiyamura%2C+Yoshinori%3BYamaguchi%2C+Yuji%3BWolber%2C+Rainer%3BSmuda%2C+Christoph%3BBatzer%2C+Jan%3BKolbe%2C+Ludger%3BIto%2C+Shosuke%3BWakamatsu%2C+Kazumasa%3BZmudzka%2C+Barbara+Z%3BBeer%2C+Janusz+Z%3BMiller%2C+Sharon+A%3BHearing%2C+Vincent+J&rft.aulast=Coelho&rft.aufirst=Sergio&rft.date=2009-08-01&rft.volume=14&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.issn=1529-1774&rft_id=info:doi/10.1038%2Fjidsymp.2009.10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-04 N1 - Date created - 2009-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2002 Jan 16;94(2):94-101 [11792747] J Investig Dermatol Symp Proc. 2001 Nov;6(1):99-104 [11764295] Dermatol Clin. 2003 Oct;21(4):725-32, x [14717413] J Cell Biol. 2004 Apr 26;165(2):275-85 [15117970] J Cell Biol. 1975 May;65(2):481-8 [1127019] J Invest Dermatol. 1986 Nov;87(5):648-52 [3772158] J Invest Dermatol. 1987 Oct;89(4):384-8 [3668281] J Int Med Res. 1990;18 Suppl 3:8C-17C [2227089] N Engl J Med. 1993 Oct 14;329(16):1193-4 [8377786] J Invest Dermatol. 1998 May;110(5):806-10 [9579550] J Investig Dermatol Symp Proc. 1998 Aug;3(1):47-51 [9732058] Eur J Dermatol. 1999 Mar;9(2):95-9 [10066954] N Engl J Med. 1999 Apr 29;340(17):1341-8 [10219070] J Invest Dermatol. 2005 Jun;124(6):1326-32 [15955111] Photodermatol Photoimmunol Photomed. 2006 Jun;22(3):124-8 [16719864] FASEB J. 2006 Jul;20(9):1486-8 [16793869] Pigment Cell Res. 2007 Feb;20(1):2-13 [17250543] J Biol Chem. 2007 Sep 21;282(38):27557-61 [17635904] Arch Dermatol Res. 2008 Apr;300 Suppl 1:S43-50 [17985102] Photochem Photobiol. 2008 May-Jun;84(3):539-49 [18435612] Pigment Cell Melanoma Res. 2008 Aug;21(4):487-91 [18627527] Br J Dermatol. 2008 Sep;159(4):921-30 [18616777] Exp Dermatol. 2008 Nov;17(11):916-24 [18363705] Pigment Cell Melanoma Res. 2009 Apr;22(2):238-41 [19226313] J Invest Dermatol. 2009 Apr;129(4):1002-11 [18946495] Photodermatol Photoimmunol Photomed. 2000 Dec;16(6):245-9 [11132126] FASEB J. 2003 Jun;17(9):1177-9 [12692083] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jidsymp.2009.10 ER - TY - JOUR T1 - CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. AN - 67565306; 19662682 AB - Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are still poorly understood. IL-23 is expressed in psoriatic skin, and IL-23 injection produces IL-22-dependent psoriasiform changes in mouse skin. Th17 cells produce IL-22 and display CCR6, the CCL20 receptor; CCR6+ T cells and CCL20 are abundant in psoriatic skin. We investigated a possible role for CCR6 in recruiting Th17 cells and producing psoriasiform pathology by injecting IL-23 into the skin of WT and Ccr6-/- mice. Unlike for WT mice, IL-23-injected ears of Ccr6-/- mice showed neither substantial epidermal/dermal changes nor increased Il22 mRNA expression. However, injection of IL-22 yielded equivalent psoriasiform changes in WT and Ccr6-/- mice. Surprisingly, IL-23-injected ears of WT and Ccr6-/- mice contained similar numbers of Th cells able to make IL-17A and/or IL-22. Furthermore, in ears of Rag1-/- mice, IL-23 initially induced skin changes and levels of Il22 mRNA that were indistinguishable from WT mice, revealing at least one non-T cell source for IL-22. We conclude that CCR6 is essential in a model of IL-23-induced, IL-22-mediated dermatitis, which develops in sequential T cell-independent and T cell-dependent phases. These findings reveal an expanded role for CCR6 in IL-23-related responses and identify CCR6 as a potential therapeutic target in psoriasis. JF - The Journal of clinical investigation AU - Hedrick, Michael N AU - Lonsdorf, Anke S AU - Shirakawa, Aiko-Konno AU - Richard Lee, Chyi-Chia AU - Liao, Fang AU - Singh, Satya P AU - Zhang, Hongwei H AU - Grinberg, Alexander AU - Love, Paul E AU - Hwang, Sam T AU - Farber, Joshua M AD - Inflammation Biology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 2317 EP - 2329 VL - 119 IS - 8 KW - CCR6 protein, mouse KW - 0 KW - Homeodomain Proteins KW - Interleukin-17 KW - Interleukin-23 KW - Interleukins KW - Receptors, CCR6 KW - interleukin-22 KW - RAG-1 protein KW - 128559-51-3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Interleukin-17 -- biosynthesis KW - Interleukins -- biosynthesis KW - Homeodomain Proteins -- physiology KW - Mice, Inbred C57BL KW - CD4-Positive T-Lymphocytes -- physiology KW - Mice KW - Dendritic Cells -- physiology KW - Interleukin-23 -- toxicity KW - Receptors, CCR6 -- physiology KW - Psoriasis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67565306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=CCR6+is+required+for+IL-23-induced+psoriasis-like+inflammation+in+mice.&rft.au=Hedrick%2C+Michael+N%3BLonsdorf%2C+Anke+S%3BShirakawa%2C+Aiko-Konno%3BRichard+Lee%2C+Chyi-Chia%3BLiao%2C+Fang%3BSingh%2C+Satya+P%3BZhang%2C+Hongwei+H%3BGrinberg%2C+Alexander%3BLove%2C+Paul+E%3BHwang%2C+Sam+T%3BFarber%2C+Joshua+M&rft.aulast=Hedrick&rft.aufirst=Michael&rft.date=2009-08-01&rft.volume=119&rft.issue=8&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Rev. 2000 Mar;52(1):145-76 [10699158] Annu Rev Immunol. 2000;18:593-620 [10837070] Immunity. 2000 May;12(5):495-503 [10843382] J Immunol. 2000 Jun 15;164(12):6621-32 [10843722] Immunity. 2000 Nov;13(5):715-25 [11114383] J Clin Invest. 2001 Mar;107(6):R37-45 [11254677] Nat Immunol. 2001 Feb;2(2):108-15 [11175802] Lancet. 2001 Jun 9;357(9271):1842-7 [11410193] J Invest Dermatol. 2001 Sep;117(3):618-26 [11564168] J Exp Med. 2001 Nov 19;194(10):1497-506 [11714756] Exp Dermatol. 2002 Apr;11(2):135-42 [11994140] J Biol Chem. 2003 Jan 17;278(3):1910-4 [12417590] Nature. 2003 Feb 13;421(6924):744-8 [12610626] J Immunol. 2003 Jun 1;170(11):5438-44 [12759419] J Clin Invest. 2008 Feb;118(2):597-607 [18202747] J Invest Dermatol. 2008 Mar;128(3):628-33 [17882271] Semin Immunol. 2007 Dec;19(6):409-17 [18053739] Nat Med. 2008 Mar;14(3):282-9 [18264109] Immunity. 2008 Apr;28(4):454-67 [18400188] J Invest Dermatol. 2008 May;128(5):1207-11 [18200064] J Invest Dermatol. 2008 May;128(5):1182-91 [18239614] J Invest Dermatol. 2008 May;128(5):1064-7 [18408745] Lancet. 2008 May 17;371(9625):1665-74 [18486739] Lancet. 2008 May 17;371(9625):1675-84 [18486740] J Immunol. 2008 Jun 1;180(11):7423-30 [18490742] Nat Immunol. 2008 Jun;9(6):650-7 [18454150] Nat Immunol. 2008 Jun;9(6):641-9 [18454151] J Exp Med. 2008 Jun 9;205(6):1381-93 [18504307] J Invest Dermatol. 2008 Jul;128(7):1653-61 [18219280] Clin Infect Dis. 2008 Jul 15;47(2):236-41 [18532888] Cytokine. 2008 Sep;43(3):402-7 [18701318] J Immunol. 2008 Dec 1;181(11):7891-901 [19017979] Eur J Immunol. 2003 Oct;33(10):2937-46 [14515278] Arch Dermatol. 2003 Dec;139(12):1627-32; discussion 1632 [14676082] J Exp Med. 2003 Dec 15;198(12):1951-7 [14662908] J Exp Med. 2004 Jan 5;199(1):125-30 [14707118] Annu Rev Immunol. 2004;22:745-63 [15032595] Nat Med. 2004 May;10(5):510-7 [15098028] J Clin Invest. 2004 Jun;113(12):1664-75 [15199399] Immunity. 2004 Aug;21(2):241-54 [15308104] J Biol Chem. 1988 Mar 5;263(7):3521-7 [2963825] Cell. 1991 Jun 28;65(7):1153-63 [2065352] J Immunol. 1999 Jan 1;162(1):186-94 [9886385] Clin Exp Dermatol. 2004 Nov;29(6):658-63 [15550147] J Exp Med. 2005 Jan 17;201(2):233-40 [15657292] Blood. 2005 Apr 1;105(7):2877-86 [15613550] N Engl J Med. 2005 May 5;352(18):1899-912 [15872205] Expert Opin Ther Targets. 2005 Apr;9(2):225-43 [15934912] Br J Dermatol. 2005 Jun;152(6):1304-12 [15948997] Blood. 2005 Jul 1;106(1):18-26 [15774622] Nat Rev Immunol. 2005 Sep;5(9):699-711 [16138103] Lancet. 2005 Oct 15-21;366(9494):1367-74 [16226614] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19057-62 [16380428] J Immunol. 2006 Feb 1;176(3):1908-15 [16424222] Immunity. 2006 Feb;24(2):191-201 [16473831] J Immunol. 2006 Apr 1;176(7):4431-9 [16547281] Eur J Immunol. 2006 May;36(5):1309-23 [16619290] Immunity. 2006 May;24(5):623-32 [16713979] J Exp Med. 2006 Oct 2;203(10):2271-9 [16982811] J Exp Med. 2006 Nov 27;203(12):2577-87 [17074928] Science. 2006 Dec 1;314(5804):1461-3 [17068223] Am J Hum Genet. 2007 Feb;80(2):273-90 [17236132] J Immunol. 2007 Feb 15;178(4):2229-40 [17277128] N Engl J Med. 2007 Feb 8;356(6):580-92 [17287478] Nature. 2007 Feb 8;445(7128):648-51 [17187052] Nature. 2007 Feb 22;445(7130):866-73 [17314973] Am J Pathol. 2007 Apr;170(4):1229-40 [17392163] Nat Immunol. 2007 Jun;8(6):639-46 [17486092] J Exp Med. 2007 Aug 6;204(8):1849-61 [17635957] Hum Genet. 2007 Sep;122(2):201-6 [17587057] Nat Immunol. 2007 Sep;8(9):950-7 [17676044] Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):374-81 [17873575] Clin Exp Immunol. 2007 Dec;150(3):407-15 [17900301] J Exp Med. 2007 Nov 26;204(12):2803-12 [18025126] Curr Opin Immunol. 2007 Dec;19(6):652-7 [17766098] J Immunol. 2008 Jan 1;180(1):214-21 [18097022] J Exp Med. 2007 Dec 24;204(13):3183-94 [18039949] Curr Rheumatol Rep. 2007 Dec;9(6):461-7 [18177599] Br J Dermatol. 2008 Nov;159(5):1092-102 [18684158] Nat Immunol. 2009 Jan;10(1):83-91 [19029903] Nat Immunol. 2009 Jan;10(1):75-82 [19029904] Immunity. 2008 Dec 19;29(6):958-70 [19084435] Nat Genet. 2009 Feb;41(2):199-204 [19169254] Nature. 2009 Feb 5;457(7230):722-5 [18978771] Nat Immunol. 2009 Mar;10(3):314-24 [19182808] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. AN - 67558666; 19275938 AB - Transcription is a sophisticated multi-step process in which RNA polymerase II (Pol II) transcribes a DNA template into RNA in concert with a broad array of transcription initiation, elongation, capping, termination, and histone modifying factors. Recent global analyses of Pol II distribution have indicated that many genes are regulated during the elongation phase, shedding light on a previously underappreciated mechanism for controlling gene expression. Understanding how various factors regulate transcription elongation in living cells has been greatly aided by chromatin immunoprecipitation (ChIP) studies, which can provide spatial and temporal resolution of protein-DNA binding events. The coupling of ChIP with DNA microarray and high-throughput sequencing technologies (ChIP-chip and ChIP-seq) has significantly increased the scope of ChIP studies and genome-wide maps of Pol II or elongation factor binding sites can now be readily produced. However, while ChIP-chip/ChIP-seq data allow for high-resolution localization of protein-DNA binding sites, they are not sufficient to dissect protein function. Here we describe techniques for coupling ChIP-chip/ChIP-seq with genetic, chemical, and experimental manipulation to obtain mechanistic insight from genome-wide protein-DNA binding studies. We have employed these techniques to discern immature promoter-proximal Pol II from productively elongating Pol II, and infer a critical role for the transition between initiation and full elongation competence in regulating development and gene induction in response to environmental signals. JF - Methods (San Diego, Calif.) AU - Gilchrist, Daniel A AU - Fargo, David C AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 398 EP - 408 VL - 48 IS - 4 KW - Chromatin KW - 0 KW - DNA-Binding Proteins KW - Peptide Elongation Factors KW - Transcription Factors KW - Index Medicus KW - DNA-Binding Proteins -- chemistry KW - Microarray Analysis -- methods KW - Immunoprecipitation -- methods KW - Genome-Wide Association Study -- methods KW - Transcription Factors -- physiology KW - Peptide Elongation Factors -- physiology KW - Chromatin -- physiology KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67558666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+%28San+Diego%2C+Calif.%29&rft.atitle=Using+ChIP-chip+and+ChIP-seq+to+study+the+regulation+of+gene+expression%3A+genome-wide+localization+studies+reveal+widespread+regulation+of+transcription+elongation.&rft.au=Gilchrist%2C+Daniel+A%3BFargo%2C+David+C%3BAdelman%2C+Karen&rft.aulast=Gilchrist&rft.aufirst=Daniel&rft.date=2009-08-01&rft.volume=48&rft.issue=4&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Methods+%28San+Diego%2C+Calif.%29&rft.issn=1095-9130&rft_id=info:doi/10.1016%2Fj.ymeth.2009.02.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-14 N1 - Date created - 2009-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Oct 1;14(19):2452-60 [11018013] Science. 2008 Mar 28;319(5871):1791-2 [18369138] Mol Cell Biol. 2002 May;22(9):2918-27 [11940650] Nucleic Acids Res. 2003 Jan 1;31(1):51-4 [12519945] Mol Cell Biol. 2003 Mar;23(6):1863-73 [12612062] Methods. 2003 Dec;31(4):265-73 [14597310] Mol Cell Biol. 1986 Nov;6(11):3984-9 [3099167] Cell. 1988 Sep 9;54(6):795-804 [3136931] Mol Cell Biol. 1990 Nov;10(11):6041-5 [2172790] Mol Cell Biol. 2008 May;28(10):3290-300 [18332113] Nat Methods. 2008 Jul;5(7):621-8 [18516045] Nucleic Acids Res. 2008 Sep;36(16):e105 [18660515] Bioinformatics. 2008 Nov 1;24(21):2537-8 [18784119] Genome Res. 2008 Nov;18(11):1851-8 [18714091] Nat Biotechnol. 2008 Nov;26(11):1293-300 [18978777] Science. 2008 Dec 19;322(5909):1845-8 [19056941] Bioinformatics. 2009 Apr 1;25(7):969-70 [19228804] J Biol Chem. 1995 May 26;270(21):12335-8 [7759473] Mol Cell Biol. 1996 Oct;16(10):5433-43 [8816456] J Biol Chem. 1996 Oct 25;271(43):27176-83 [8900211] Genes Dev. 1997 Dec 15;11(24):3306-18 [9407024] Genes Dev. 1997 Dec 15;11(24):3319-26 [9407025] Mol Cell. 1998 Aug;2(2):213-22 [9734358] J Biol Chem. 1999 Mar 19;274(12):8085-92 [10075709] Methods Enzymol. 1999;304:462-96 [10372377] Mol Cell. 2005 Jan 7;17(1):103-12 [15629721] FEBS Lett. 2005 Feb 7;579(4):909-15 [15680973] Nature. 2005 Aug 11;436(7052):876-80 [15988478] Cell. 2005 Aug 26;122(4):517-27 [16122420] Nature. 2005 Sep 15;437(7057):376-80 [16056220] Mol Cell. 2006 Aug 4;23(3):297-305 [16885020] Nat Biotechnol. 2006 Aug;24(8):963-70 [16900145] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12457-62 [16895995] Nat Rev Mol Cell Biol. 2006 Aug;7(8):557-67 [16936696] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Curr Opin Genet Dev. 2007 Apr;17(2):94-9 [17317148] Genes Dev. 2007 May 1;21(9):1031-6 [17473169] Science. 2007 Jun 8;316(5830):1497-502 [17540862] Nature. 2007 Jun 14;447(7146):799-816 [17571346] Cell. 2007 Jul 13;130(1):77-88 [17632057] J Biol Chem. 2007 Jul 27;282(30):21901-12 [17548348] Nature. 2007 Aug 2;448(7153):553-60 [17603471] Nat Genet. 2007 Dec;39(12):1512-6 [17994019] Nat Genet. 2007 Dec;39(12):1507-11 [17994021] Bioinformatics. 2008 Mar 1;24(5):713-4 [18227114] Genome Res. 2008 Mar;18(3):393-403 [18258921] Cell. 2008 Mar 7;132(5):887-98 [18329373] J Biol Chem. 2001 Nov 9;276(45):42601-9 [11553615] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ymeth.2009.02.024 ER - TY - JOUR T1 - Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy. AN - 67555299; 19491224 AB - Pheochromocytomas and paragangliomas are rare catecholamine-secreting neuroendocrine tumors arising from the adrenal medulla and sympathetic tissues. When complete surgical resection is not an option, the treatment of pheochromocytoma is limited. The objective of the study was to identify and characterize overexpression of IL-13 receptor-alpha2 (IL-13Ralpha2) gene expression in human and murine tumors and verify xenograft mouse pheochromocytoma cell (MPC)-derived tumor's response to a selective cytotoxin. Expression of IL-13Ralpha2 was evaluated in a panel of 25 human pheochromocytoma clinical samples by RT-PCR and eight MPC tumors by indirect immunofluorescence assay and RT-PCR. The function of IL-13Ralpha2 in these tumor cells was examined by evaluating tumor sensitivity to a recombinant IL-13-Pseudomonas exotoxin (IL-13PE). Subcutaneous small and large MPC tumors in athymic nude mice (n = 10) were treated intratumorally with IL-13PE (100 m icrog/kg). IC(50) and tumor size were measured. IL-13PE immunotoxin was highly cytotoxic to IL-13Ralpha2-overexpressing MPC cells (IC(50) <2.5 ng/ml) in vitro. Furthermore, IL-13PE was highly cytotoxic to sc tumors. Our results showed a statistically significant decrease in tumor size as early as 3 d after initial treatment and further suppressed growth of MPC tumors. All tumors displayed a histological evidence of necrosis in response to IL-13 immunotoxin without any adverse effects in host at this dose. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. JF - The Journal of clinical endocrinology and metabolism AU - Lai, Edwin W AU - Joshi, Bharat H AU - Martiniova, Lucia AU - Dogra, Ritika AU - Fujisawa, Toshio AU - Leland, Pamela AU - de Krijger, Ronald R AU - Lubensky, Irina A AU - Elkahloun, Abdel G AU - Morris, John C AU - Puri, Raj K AU - Pacak, Karel AD - Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1109, USA. karel@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 2952 EP - 2957 VL - 94 IS - 8 KW - Bacterial Proteins KW - 0 KW - Immunotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - pseudomonas exoprotein A protein, Pseudomonas aeruginosa KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Bacterial Proteins -- therapeutic use KW - Humans KW - Mice KW - Cell Line, Tumor KW - Immunotoxins -- pharmacology KW - Female KW - Interleukin-13 Receptor alpha2 Subunit -- physiology KW - Adrenal Gland Neoplasms -- metabolism KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Pheochromocytoma -- drug therapy KW - Adrenal Gland Neoplasms -- pathology KW - Interleukin-13 Receptor alpha2 Subunit -- analysis KW - Pheochromocytoma -- pathology KW - Pheochromocytoma -- metabolism KW - Adrenal Gland Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67555299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Overexpression+of+interleukin-13+receptor-alpha2+in+neuroendocrine+malignant+pheochromocytoma%3A+a+novel+target+for+receptor+directed+anti-cancer+therapy.&rft.au=Lai%2C+Edwin+W%3BJoshi%2C+Bharat+H%3BMartiniova%2C+Lucia%3BDogra%2C+Ritika%3BFujisawa%2C+Toshio%3BLeland%2C+Pamela%3Bde+Krijger%2C+Ronald+R%3BLubensky%2C+Irina+A%3BElkahloun%2C+Abdel+G%3BMorris%2C+John+C%3BPuri%2C+Raj+K%3BPacak%2C+Karel&rft.aulast=Lai&rft.aufirst=Edwin&rft.date=2009-08-01&rft.volume=94&rft.issue=8&rft.spage=2952&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2009-0309 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Med. 2002 Aug;8(8):487-94 [12435859] Clin Cancer Res. 2002 Jun;8(6):1948-56 [12060640] J Neurooncol. 2003 Oct;65(1):37-48 [14649884] Mol Cancer Ther. 2004 Feb;3(2):137-47 [14985454] J Immunol. 1997 Jan 15;158(2):756-64 [8992992] Biochem Biophys Res Commun. 1997 Sep 8;238(1):90-4 [9299458] Int Immunol. 1998 Aug;10(8):1103-10 [9723696] Protein Expr Purif. 2005 Feb;39(2):189-98 [15642470] J Immunother. 2005 May-Jun;28(3):193-202 [15838375] Nat Med. 2006 Jan;12(1):99-106 [16327802] Technol Cancer Res Treat. 2006 Jun;5(3):239-50 [16700620] Cancer. 2006 Sep 15;107(6):1407-18 [16902988] Vitam Horm. 2006;74:479-504 [17027527] Ann N Y Acad Sci. 2006 Aug;1073:1-20 [17102067] Ann N Y Acad Sci. 2006 Aug;1073:541-56 [17102123] J Clin Oncol. 2007 Mar 1;25(7):837-44 [17327604] J Clin Endocrinol Metab. 2007 Apr;92(4):1217-25 [17284633] Cell Cycle. 2007 Aug 1;6(15):1946-50 [17671425] J Clin Endocrinol Metab. 2007 Dec;92(12):4865-72 [17878247] Horm Metab Res. 2008 May;40(5):329-37 [18491252] J Pathol. 2009 Mar;217(4):597-604 [19142977] Cancer Res. 2000 Mar 1;60(5):1168-72 [10728667] Cell Tissue Res. 2000 Dec;302(3):309-20 [11151443] Ann Intern Med. 2001 Feb 20;134(4):315-29 [11182843] Int J Cancer. 2001 Apr 15;92(2):168-75 [11291041] Gene Ther. 2003 Jul;10(13):1116-28 [12808442] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/jc.2009-0309 ER - TY - JOUR T1 - Haptoglobin halts hemoglobin's havoc. AN - 67553970; 19620777 AB - Hemoglobin (Hb) is crucial to the function of the red blood cell. However, when it is released during intravascular hemolysis from the cell into blood plasma, it produces a state of NO depletion, oxidant stress, and vascular dysfunction, including hypertension. In their study reported in this issue of the JCI, Boretti and colleagues used canine and guinea pig models to demonstrate that pharmacological doses of glucocorticoid can increase the plasma levels of haptoglobin (Hp), the principal plasma-binding protein for free Hb (see the related article beginning on page 2271). Hp prevented Hb-induced hypertension and the generation of oxidant damage to the kidney. Neutralization of free Hb appears to be part of the downstream antiinflammatory properties of glucocorticoid. JF - The Journal of clinical investigation AU - Kato, Gregory J AD - Sickle Cell Vascular Disease Section, Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, and Critical Care Medicine Department, Clinical Center, National Institutes of Health, Maryland 20892-1476, USA. gkato@nhlbi.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 2140 EP - 2142 VL - 119 IS - 8 KW - Glucocorticoids KW - 0 KW - Haptoglobins KW - Hemoglobins KW - Nitric Oxide KW - 31C4KY9ESH KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Humans KW - Plasma Exchange KW - Oxidative Stress KW - Inflammation -- blood KW - Hemolysis KW - Dogs KW - Nitric Oxide -- metabolism KW - Glucocorticoids -- pharmacology KW - Hemoglobins -- metabolism KW - Hemoglobins -- toxicity KW - Haptoglobins -- physiology KW - Haptoglobins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67553970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Haptoglobin+halts+hemoglobin%27s+havoc.&rft.au=Kato%2C+Gregory+J&rft.aulast=Kato&rft.aufirst=Gregory&rft.date=2009-08-01&rft.volume=119&rft.issue=8&rft.spage=2140&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI40258 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 May 9;97(10):5450-5 [10805801] Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):151-62 [10942618] J Am Coll Cardiol. 2002 Dec 4;40(11):1984-90 [12475459] Circ Res. 2003 Jun 13;92(11):1193-200 [12750308] Semin Hematol. 1966 Oct;3(4):351-75 [5341723] N Engl J Med. 1994 Mar 17;330(11):733-7 [8107739] Acta Anaesthesiol Scand. 1997 May;41(5):647-50 [9181170] Blood. 1998 Nov 1;92(9):3082-9 [9787142] Circ Res. 2005 Mar 4;96(4):435-41 [15662028] JAMA. 2005 Apr 6;293(13):1653-62 [15811985] Blood. 2005 Oct 1;106(7):2572-9 [15947085] J Clin Invest. 2005 Dec;115(12):3409-17 [16294219] Blood. 2006 Jan 1;107(1):373-80 [16189277] Transfusion. 2006 Jan;46(1):105-10 [16398738] Blood. 2006 Jan 15;107(2):566-74 [16195332] Immunobiology. 2006;211(6-8):407-17 [16920480] Hematology Am Soc Hematol Educ Program. 2006;:415-20 [17124092] Blood Rev. 2007 Jan;21(1):37-47 [17084951] Antioxid Redox Signal. 2007 Jul;9(7):991-9 [17508920] Pediatr Blood Cancer. 2008 May;50(5):1006-12 [17849474] Cardiol Rev. 2009 May-Jun;17(3):99-111 [19384082] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] Comment On: J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI40258 ER - TY - JOUR T1 - Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. AN - 67553828; 19585654 AB - MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it is heterogeneous in clinical outcomes and biological activities. Recently, we have identified a subset of highly invasive epithelial cell adhesion molecule (EpCAM)(+) HCC cells from alpha-fetoprotein (AFP)(+) tumors with cancer stem/progenitor cell features, that is, the abilities to self-renew, differentiate, and initiate aggressive tumors in vivo. Here, using a global microarray-based miRNA profiling approach followed by validation with quantitative reverse transcription polymerase chain reaction, we have demonstrated that conserved miR-181 family members were up-regulated in EpCAM(+)AFP(+) HCCs and in EpCAM(+) HCC cells isolated from AFP(+) tumors. Moreover, miR-181 family members were highly expressed in embryonic livers and in isolated hepatic stem cells. Importantly, inhibition of miR-181 led to a reduction in EpCAM(+) HCC cell quantity and tumor initiating ability, whereas exogenous miR-181 expression in HCC cells resulted in an enrichment of EpCAM(+) HCC cells. We have found that miR-181 could directly target hepatic transcriptional regulators of differentiation (for example, caudal type homeobox transcription factor 2 [CDX2] and GATA binding protein 6 [GATA6]) and an inhibitor of Wnt/beta-catenin signaling (nemo-like kinase [NLK]). Taken together, our results define a novel regulatory link between miR-181s and human EpCAM(+) liver cancer stem/progenitor cells and imply that molecular targeting of miR-181 may eradicate HCC. JF - Hepatology (Baltimore, Md.) AU - Ji, Junfang AU - Yamashita, Taro AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Jia, Hu-Liang AU - Li, Cuiling AU - Deng, Chuxia AU - Wauthier, Elaine AU - Reid, Lola M AU - Ye, Qing-Hai AU - Qin, Lun-Xiu AU - Yang, Wen AU - Wang, Hong-Yang AU - Tang, Zhao-You AU - Croce, Carlo M AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 472 EP - 480 VL - 50 IS - 2 KW - Antigens, Neoplasm KW - 0 KW - CDX2 Transcription Factor KW - CDX2 protein, human KW - Cell Adhesion Molecules KW - Epithelial Cell Adhesion Molecule KW - GATA6 Transcription Factor KW - GATA6 protein, human KW - Homeodomain Proteins KW - Intracellular Signaling Peptides and Proteins KW - MIrn181 microRNA, human KW - MicroRNAs KW - NLK protein, human KW - EC 2.7.1.- KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Index Medicus KW - Gene Expression Profiling KW - Protein-Serine-Threonine Kinases -- metabolism KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Multigene Family KW - Humans KW - GATA6 Transcription Factor -- metabolism KW - Homeodomain Proteins -- metabolism KW - Male KW - Female KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - MicroRNAs -- metabolism KW - Cell Adhesion Molecules -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Neoplastic Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67553828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Identification+of+microRNA-181+by+genome-wide+screening+as+a+critical+player+in+EpCAM-positive+hepatic+cancer+stem+cells.&rft.au=Ji%2C+Junfang%3BYamashita%2C+Taro%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BJia%2C+Hu-Liang%3BLi%2C+Cuiling%3BDeng%2C+Chuxia%3BWauthier%2C+Elaine%3BReid%2C+Lola+M%3BYe%2C+Qing-Hai%3BQin%2C+Lun-Xiu%3BYang%2C+Wen%3BWang%2C+Hong-Yang%3BTang%2C+Zhao-You%3BCroce%2C+Carlo+M%3BWang%2C+Xin+Wei&rft.aulast=Ji&rft.aufirst=Junfang&rft.date=2009-08-01&rft.volume=50&rft.issue=2&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-21 N1 - Date created - 2009-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Physiol. 2006 Nov;209(2):266-9 [16791837] Stem Cells. 2006 Aug;24(8):1852-8 [16627685] Cell. 2006 Nov 3;127(3):469-80 [17081971] Nature. 2007 Jan 4;445(7123):111-5 [17122771] Nature. 2007 Jan 4;445(7123):106-10 [17122772] Exp Hematol. 2007 Apr;35(4):551-64 [17379065] Gastroenterology. 2007 Jun;132(7):2542-56 [17570225] J Exp Med. 2007 Aug 6;204(8):1973-87 [17664288] Cancer Res. 2007 Nov 15;67(22):10831-9 [18006828] Cancer Cell. 2008 Feb;13(2):153-66 [18242515] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] Hepatology. 2008 Mar;47(3):897-907 [18176954] Nat Cell Biol. 2009 Feb;11(2):162-71 [19136966] Gastroenterology. 2009 Mar;136(3):1012-24 [19150350] N Engl J Med. 2006 Sep 21;355(12):1253-61 [16990388] Blood. 2000 Apr 1;95(7):2275-83 [10733496] Nat Rev Genet. 2002 Jul;3(7):499-512 [12094228] Mol Cell Biol. 2003 Jan;23(1):131-9 [12482967] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Genes Dev. 2003 May 15;17(10):1253-70 [12756227] Nat Genet. 2003 Nov;35(3):215-7 [14528307] Cell. 2003 Dec 26;115(7):787-98 [14697198] Science. 2004 Jan 2;303(5654):83-6 [14657504] Nat Rev Cancer. 2003 Dec;3(12):895-902 [14737120] Dev Biol. 2004 Jun 15;270(2):488-98 [15183728] Dev Biol. 1996 Apr 10;175(1):1-13 [8608856] J Pathol. 1999 Jun;188(2):201-6 [10398165] Nature. 2004 Nov 18;432(7015):396-401 [15549107] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Mol Cell Biol. 2005 Apr;25(7):2622-31 [15767668] Nat Genet. 2005 May;37(5):495-500 [15806104] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Nature. 2005 Jun 16;435(7044):974-8 [15944714] Cell. 2005 Jul 15;122(1):6-7 [16009126] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):77-83 [15979674] Cancer Res. 2005 Oct 15;65(20):9328-37 [16230395] Nat Cell Biol. 2006 Mar;8(3):278-84 [16489342] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5078-83 [16549775] Nat Med. 2006 Apr;12(4):410-6 [16532004] Annu Rev Plant Biol. 2006;57:19-53 [16669754] Comment In: Hepatology. 2009 Dec;50(6):2047-8; author reply 448 [19937678] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22989 ER - TY - JOUR T1 - Indoor allergens in school and day care environments. AN - 67553725; 19577284 AB - Most studies that have examined exposure to indoor allergens have focused on home environments. However, allergen exposures can be encountered in environments other than the home. For example, many children spend a large part of their time in schools and day care facilities. Over the past 2 decades, a large number of studies have been conducted in school and day care environments. However, the role of indoor exposures in allergy and asthma development or morbidity in these settings is not well characterized. The purpose of this review is to evaluate the importance of indoor allergen exposures in school and day care settings. We summarize the key findings from recent scientific literature, describe exposure characteristics, discuss the role of these exposures in relation to asthma and allergy symptoms, and provide information on the effectiveness of published interventions. JF - The Journal of allergy and clinical immunology AU - Salo, Päivi M AU - Sever, Michelle L AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 185 EP - 92, 192.e1-9; quiz 193-4 VL - 124 IS - 2 KW - Allergens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Environmental Monitoring KW - Animals KW - Schools -- trends KW - Inhalation Exposure -- prevention & control KW - Child Day Care Centers -- standards KW - Child Day Care Centers -- trends KW - Humans KW - Schools -- standards KW - Cats KW - Dogs KW - Epidemiological Monitoring KW - Child KW - Environmental Exposure -- prevention & control KW - Hypersensitivity -- epidemiology KW - Allergens -- immunology KW - Hypersensitivity -- immunology KW - Hypersensitivity -- prevention & control KW - Air Pollution, Indoor -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67553725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Indoor+allergens+in+school+and+day+care+environments.&rft.au=Salo%2C+P%C3%A4ivi+M%3BSever%2C+Michelle+L%3BZeldin%2C+Darryl+C&rft.aulast=Salo&rft.aufirst=P%C3%A4ivi&rft.date=2009-08-01&rft.volume=124&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2009.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Exp Allergy. 1996 Nov;26(11):1246-52 [8955573] N Engl J Med. 1997 May 8;336(19):1356-63 [9134876] J Allergy Clin Immunol. 1997 Apr;99(4):486-92 [9111492] Ann Allergy Asthma Immunol. 1997 Jun;78(6):544-54; quiz 555-6 [9207717] Allergy Asthma Proc. 2007 Jan-Feb;28(1):3-9 [17390749] Indoor Air. 2007 Apr;17(2):122-9 [17391234] MMWR Surveill Summ. 2002 Mar 29;51(1):1-13 [12420904] Int J Hyg Environ Health. 2002 Oct;205(6):453-7 [12455267] Ann Allergy Asthma Immunol. 2003 Jan;90(1):34-40 [12546335] J Allergy Clin Immunol. 2003 Feb;111(2):285-9 [12589346] Ann Allergy Asthma Immunol. 2003 Feb;90(2):203-8 [12602667] Indoor Air. 2003 Mar;13(1):53-64 [12608926] Clin Exp Allergy. 2002 Dec;32(12):1776-81 [12653171] J Allergy Clin Immunol. 2003 Aug;112(2):362-8 [12897743] Cent Eur J Public Health. 2004 Mar;12(1):36-42 [15068207] J Expo Anal Environ Epidemiol. 2004;14 Suppl 1:S41-8 [15118744] Allergy. 2004 Jun;59(6):661-7 [15147452] J Allergy Clin Immunol. 2004 Jun;113(6):1172-7 [15208601] Indoor Air. 2007 Apr;17(2):153-63 [17391238] Am J Ind Med. 2008 Jan;51(1):47-59 [18033692] Allergy Asthma Proc. 2008 Jan-Feb;29(1):29-34 [18302835] Ann Allergy Asthma Immunol. 2008 Apr;100(4):358-63 [18450122] Pediatr Allergy Immunol. 2008 Dec;19(8):746-55 [18208465] Ann Allergy Asthma Immunol. 2009 Feb;102(2):125-30 [19230463] J Occup Environ Hyg. 2005 Nov;2(11):553-66 [16223714] Arch Environ Health. 2000 Jan-Feb;55(1):18-25 [10735515] Environ Health Perspect. 2000 Aug;108 Suppl 4:653-9 [10931783] J Allergy Clin Immunol. 2000 Nov;106(5):874-9 [11080709] Arch Environ Health. 2000 Nov-Dec;55(6):405-10 [11128878] Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):694-8 [11254526] Ann Allergy Asthma Immunol. 2001 Sep;87(3):196-200 [11570614] Int J Tuberc Lung Dis. 2001 Nov;5(11):1059-66 [11716342] J Sch Health. 2002 Jan;72(1):33-8 [11865797] Allergy. 2002 Apr;57(4):357-61 [11906369] Arch Environ Health. 1997 Jul-Aug;52(4):281-5 [9210728] Clin Exp Allergy. 1997 Aug;27(8):876-85 [9291283] Clin Exp Allergy. 1997 Nov;27(11):1270-8 [9420130] J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):S2-24 [9438476] J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):755-9 [9438482] Clin Exp Allergy. 1998 Jan;28(1):53-9 [9537780] Allergy. 1998 Feb;53(2):120-8 [9534909] Pediatr Allergy Immunol. 1998 Feb;9(1):25-30 [9560839] Clin Exp Allergy. 1999 May;29(5):626-32 [10231322] J Allergy Clin Immunol. 1999 Jun;103(6):1012-7 [10359879] J Allergy Clin Immunol. 1999 Jun;103(6):1018-24 [10359880] Pediatr Allergy Immunol. 1999 Feb;10(1):45-52 [10410917] Environ Health Perspect. 1999 Jun;107 Suppl 3:509-14 [10423392] Allergy. 1998;53(48 Suppl):1-135 [10465730] J Allergy Clin Immunol. 2004 Dec;114(6):1282-7 [15577824] Clin Exp Allergy. 2005 Feb;35(2):126-36 [15725182] Ann Allergy Asthma Immunol. 2005 Mar;94(3):313-9; quiz 319-22, 390 [15801241] Indoor Air. 2005 Jun;15(3):170-82 [15865617] Indoor Air. 2005;15 Suppl 10:40-7 [15926943] Allergy. 2005 Jul;60(7):961-4 [15932389] Indoor Air. 2005 Aug;15(4):228-34 [15982269] J Allergy Clin Immunol. 2005 Jul;116(1):133-9 [15990786] Indoor Air. 2005 Oct;15(5):356-62 [16108908] Indoor Air. 2005 Dec;15(6):402-7 [16268830] Indoor Air. 2006 Feb;16(1):74-80 [16420500] J Sch Health. 2006 Jan;76(1):18-24 [16457681] J Sch Health. 2006 Aug;76(6):202-4 [16918838] J Sch Health. 2006 Aug;76(6):246-9 [16918848] Indoor Air. 2006 Dec;16(6):404-13 [17100662] N Z Med J. 2007;120(1248):U2400 [17277816] J Environ Monit. 2007 Mar;9(3):225-33 [17344947] Allergy. 2002 May;57(5):454-7 [11972488] Curr Allergy Asthma Rep. 2002 Sep;2(5):401-11 [12165207] Indoor Air. 2002 Sep;12(3):175-83 [12244747] J Allergy Clin Immunol. 2002 Oct;110(4):582-8 [12373265] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):427-32 [12415491] Clin Exp Allergy. 2004 Oct;34(10):1634-41 [15479281] J Allergy Clin Immunol. 1989 Feb;83(2 Pt 1):416-27 [2645343] N Engl J Med. 1990 Aug 23;323(8):502-7 [2377175] J Allergy Clin Immunol. 1993 May;91(5):1067-74 [8491939] Allergy. 1994 Apr;49(4):210-6 [8037353] Clin Exp Allergy. 1995 Feb;25(2):119-26 [7750003] J Allergy Clin Immunol. 1995 May;95(5 Pt 1):1049-53 [7751503] J Allergy Clin Immunol. 1995 Jun;95(6):1158-63 [7797783] Clin Exp Allergy. 1995 Jun;25(6):549-53 [7648462] J Allergy Clin Immunol. 1995 Oct;96(4):449-56 [7560654] Ann Allergy Asthma Immunol. 1996 Mar;76(3):257-60 [8634880] Allergy. 1996 Jan;51(1):36-41 [8721526] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2009.05.012 ER - TY - JOUR T1 - Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. AN - 67547140; 19557000 AB - Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent transcription-blocking lesions-also produce transcription-dependent DNA double-strand breaks (DSBs) with ATM activation. We show the induction of DSBs and DDR activation in post-mitotic primary neurons and lymphocytes treated with camptothecin, with the induction of nuclear DDR foci containing activated ATM, gamma-H2AX (phosphorylated histone H2AX), activated CHK2 (checkpoint kinase 2), MDC1 (mediator of DNA damage checkpoint 1) and 53BP1 (p53 binding protein 1). The DSB-ATM-DDR pathway was suppressed by inhibiting transcription and gamma-H2AX signals were reduced by RNase H1 transfection, which removes transcription-mediated R-loops. Thus, we propose that Top1cc produce transcription arrests with R-loop formation and generate DSBs that activate ATM in post-mitotic cells. JF - EMBO reports AU - Sordet, Olivier AU - Redon, Christophe E AU - Guirouilh-Barbat, Josée AU - Smith, Susan AU - Solier, Stéphanie AU - Douarre, Céline AU - Conti, Chiara AU - Nakamura, Asako J AU - Das, Benu B AU - Nicolas, Estelle AU - Kohn, Kurt W AU - Bonner, William M AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 887 EP - 893 VL - 10 IS - 8 KW - Alpha-Amanitin KW - 0 KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Enzyme Inhibitors KW - H2AFX protein, human KW - Histones KW - Intracellular Signaling Peptides and Proteins KW - MDC1 protein, human KW - Nuclear Proteins KW - Nucleic Acid Synthesis Inhibitors KW - TP53BP1 protein, human KW - Trans-Activators KW - Tumor Suppressor Proteins KW - Tumor Suppressor p53-Binding Protein 1 KW - Dichlororibofuranosylbenzimidazole KW - 53-85-0 KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - Ribonuclease H KW - EC 3.1.26.4 KW - ribonuclease HI KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Microscopy, Confocal KW - Trans-Activators -- metabolism KW - Animals KW - Neurons -- metabolism KW - Alpha-Amanitin -- pharmacology KW - Camptothecin -- pharmacology KW - Neurons -- drug effects KW - Humans KW - Dichlororibofuranosylbenzimidazole -- pharmacology KW - Transcription, Genetic -- genetics KW - Lymphocytes -- metabolism KW - Ribonuclease H -- metabolism KW - Rats KW - Nucleic Acid Synthesis Inhibitors -- pharmacology KW - Microscopy, Fluorescence KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Cells, Cultured KW - Histones -- metabolism KW - Signal Transduction -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Flow Cytometry KW - Nuclear Proteins -- metabolism KW - Lymphocytes -- drug effects KW - Transcription, Genetic -- physiology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - DNA Breaks, Double-Stranded KW - DNA Topoisomerases, Type I -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67547140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+reports&rft.atitle=Ataxia+telangiectasia+mutated+activation+by+transcription-+and+topoisomerase+I-induced+DNA+double-strand+breaks.&rft.au=Sordet%2C+Olivier%3BRedon%2C+Christophe+E%3BGuirouilh-Barbat%2C+Jos%C3%A9e%3BSmith%2C+Susan%3BSolier%2C+St%C3%A9phanie%3BDouarre%2C+C%C3%A9line%3BConti%2C+Chiara%3BNakamura%2C+Asako+J%3BDas%2C+Benu+B%3BNicolas%2C+Estelle%3BKohn%2C+Kurt+W%3BBonner%2C+William+M%3BPommier%2C+Yves&rft.aulast=Sordet&rft.aufirst=Olivier&rft.date=2009-08-01&rft.volume=10&rft.issue=8&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=EMBO+reports&rft.issn=1469-3178&rft_id=info:doi/10.1038%2Fembor.2009.97 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-15 N1 - Date created - 2009-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Apr 9;279(15):14587-94 [14688260] Cancer Res. 2004 Apr 1;64(7):2390-6 [15059890] Nat Rev Cancer. 2004 Sep;4(9):727-37 [15343279] Nature. 2004 Oct 21;431(7011):997-1002 [15496926] J Cell Biol. 1996 Aug;134(3):757-70 [8707853] Cell. 2005 Aug 12;122(3):365-78 [16096057] Trends Biochem Sci. 2006 Jul;31(7):402-10 [16774833] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] EMBO J. 2006 Dec 13;25(24):5775-82 [17124492] J Biol Chem. 2007 Mar 2;282(9):6582-7 [17189255] Biochimie. 2007 Apr;89(4):482-9 [17336444] Science. 2007 May 25;316(5828):1160-6 [17525332] Nature. 2007 Jun 7;447(7145):730-4 [17554310] Cell. 2007 Sep 21;130(6):991-1004 [17889645] J Biol Chem. 2008 Jul 25;283(30):21074-83 [18515798] Mol Cell. 2008 Jul 25;31(2):167-77 [18657500] J Mol Biol. 2008 Sep 5;381(3):540-9 [18588899] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Nat Cell Biol. 2009 Feb;11(2):211-8 [19151707] Adv Cancer Res. 2001;80:189-216 [11034544] Front Biosci. 2003 Jan 1;8:d210-21 [12456359] Nature. 2003 Jan 30;421(6922):499-506 [12556884] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] Nat Rev Mol Cell Biol. 2003 Sep;4(9):712-20 [14506474] Mol Cell. 2003 Sep;12(3):711-21 [14527416] Cancer Res. 2003 Dec 1;63(23):8203-11 [14678976] Neuron. 2004 Feb 19;41(4):549-61 [14980204] Oncogene. 2004 Mar 11;23(10):1911-21 [14755251] Cell. 2004 Jul 9;118(1):9-17 [15242640] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/embor.2009.97 ER - TY - JOUR T1 - Adverse effects of anticancer agents that target the VEGF pathway. AN - 67543951; 19581909 AB - Antiangiogenesis agents that target the VEGF/VEGF receptor pathway have become an important part of standard therapy in multiple cancer indications. With expanded clinical experience with this class of agents has come the increasing recognition of the diverse adverse effects related to disturbance of VEGF-dependent physiological functions and homeostasis in the cardiovascular and renal systems, as well as wound healing and tissue repair. Although most adverse effects of VEGF inhibitors are modest and manageable, some are associated with serious and life-threatening consequences, particularly in high-risk patients and in certain clinical settings. This Review examines the toxicity profiles of anti-VEGF antibodies and small-molecule inhibitors. The potential mechanisms of the adverse effects, risk factors, and the implications for selection of patients and management are discussed. JF - Nature reviews. Clinical oncology AU - Chen, Helen X AU - Cleck, Jessica N AD - Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20851, USA. helen.chen@nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 465 EP - 477 VL - 6 IS - 8 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Benzenesulfonates KW - Indoles KW - Neoplasm Proteins KW - Phenylurea Compounds KW - Protein Kinase Inhibitors KW - Pyridines KW - Pyrroles KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - Niacinamide KW - 25X51I8RD4 KW - Bevacizumab KW - 2S9ZZM9Q9V KW - sorafenib KW - 9ZOQ3TZI87 KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Pyrroles -- adverse effects KW - Drug Interactions KW - Humans KW - Indoles -- adverse effects KW - Capillary Leak Syndrome -- chemically induced KW - Pyridines -- therapeutic use KW - Pyrroles -- therapeutic use KW - Antibodies, Monoclonal -- pharmacology KW - Pyrroles -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use KW - Protein Kinase Inhibitors -- therapeutic use KW - Brain Diseases -- chemically induced KW - Forecasting KW - Pyridines -- adverse effects KW - Drug Delivery Systems KW - Benzenesulfonates -- therapeutic use KW - Benzenesulfonates -- pharmacology KW - Protein Kinase Inhibitors -- pharmacology KW - Wound Healing -- drug effects KW - Niacinamide -- analogs & derivatives KW - Gastrointestinal Diseases -- chemically induced KW - Clinical Trials as Topic -- statistics & numerical data KW - Benzenesulfonates -- adverse effects KW - Protein Kinase Inhibitors -- adverse effects KW - Risk Factors KW - Indoles -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Indoles -- pharmacology KW - Pyridines -- pharmacology KW - Angiogenesis Inhibitors -- therapeutic use KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Neoplasm Proteins -- antagonists & inhibitors KW - Cardiovascular Diseases -- therapy KW - Vascular Endothelial Growth Factor A -- physiology KW - Kidney Diseases -- therapy KW - Cardiovascular Diseases -- chemically induced KW - Hemorrhage -- therapy KW - Antineoplastic Agents -- adverse effects KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Angiogenesis Inhibitors -- pharmacology KW - Neoplasm Proteins -- physiology KW - Receptors, Vascular Endothelial Growth Factor -- physiology KW - Hemorrhage -- chemically induced KW - Angiogenesis Inhibitors -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67543951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Clinical+oncology&rft.atitle=Adverse+effects+of+anticancer+agents+that+target+the+VEGF+pathway.&rft.au=Chen%2C+Helen+X%3BCleck%2C+Jessica+N&rft.aulast=Chen&rft.aufirst=Helen&rft.date=2009-08-01&rft.volume=6&rft.issue=8&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Clinical+oncology&rft.issn=1759-4782&rft_id=info:doi/10.1038%2Fnrclinonc.2009.94 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nrclinonc.2009.94 ER - TY - JOUR T1 - New clinical and research trends in lower extremity management for ambulatory children with cerebral palsy. AN - 67543269; 19643348 AB - Cerebral palsy (CP) is the most prevalent physical disability in childhood and includes a group of disorders with varying manifestations. This article focuses on current and future intervention strategies for improving mobility and participation during the lifespan for ambulatory children with CP. The provision and integration of physical therapy and medical and orthopedic surgery management focused primarily on the lower extremities are discussed here. Some of the newer trends are more intense and task-related exercise strategies, greater precision in tone identification and management, and a shift towards musculoskeletal surgery that focuses more on promoting dynamic bony alignment and less on releasing or lengthening tendons. Advances in basic and clinical science and technology development are changing existing paradigms and offering renewed hope for improved functioning for children with CP who face a lifelong disability with unique challenges at each stage in life. JF - Physical medicine and rehabilitation clinics of North America AU - Damiano, Diane L AU - Alter, Katharine E AU - Chambers, Henry AD - Functional & Applied Biomechanics Section, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. damianod@cc.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 469 EP - 491 VL - 20 IS - 3 KW - Neuromuscular Agents KW - 0 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Botulinum Toxins -- therapeutic use KW - Physical Therapy Modalities KW - Humans KW - Treatment Outcome KW - Neuromuscular Agents -- therapeutic use KW - Child KW - Gait KW - Outpatients KW - Mobility Limitation KW - Leg KW - Biomedical Research -- trends KW - Cerebral Palsy -- rehabilitation KW - Muscle Spasticity -- rehabilitation KW - Cerebral Palsy -- complications KW - Orthopedic Procedures -- methods KW - Muscle Spasticity -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67543269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+medicine+and+rehabilitation+clinics+of+North+America&rft.atitle=New+clinical+and+research+trends+in+lower+extremity+management+for+ambulatory+children+with+cerebral+palsy.&rft.au=Damiano%2C+Diane+L%3BAlter%2C+Katharine+E%3BChambers%2C+Henry&rft.aulast=Damiano&rft.aufirst=Diane&rft.date=2009-08-01&rft.volume=20&rft.issue=3&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Physical+medicine+and+rehabilitation+clinics+of+North+America&rft.issn=1558-1381&rft_id=info:doi/10.1016%2Fj.pmr.2009.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-07-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Dev Med Child Neurol Suppl. 2007 Feb;109:8-14 [17370477] Neurophysiol Clin. 2007 Jan-Mar;37(1):23-8 [17418354] Cochrane Database Syst Rev. 2007;(2):CD004149 [17443542] Childs Nerv Syst. 2007 Sep;23(9):1015-31 [17624501] Acta Neurochir Suppl. 2007;97(Pt 1):193-203 [17691377] J Bone Joint Surg Br. 2007 Aug;89(8):993-4 [17785733] Int J Qual Health Care. 2007 Oct;19(5):281-8 [17666425] Gait Posture. 2007 Oct;26(4):475-81 [17855096] Expert Rev Neurother. 2007 Oct;7(10):1417-36 [17939776] Phys Occup Ther Pediatr. 2007;27(4):43-65 [18032149] Phys Ther. 2008 Jan;88(1):88-97 [17940104] BMC Musculoskelet Disord. 2007;8:101 [17963501] Parkinsonism Relat Disord. 2007;13 Suppl 3:S362-8 [18267265] Neurology. 2008 Feb 26;70(9):695-9 [18299520] Pediatrics. 2008 Mar;121(3):547-54 [18310204] J Biomech. 2008;41(5):960-7 [18291404] Dev Med Child Neurol. 2008 Apr;50(4):249-53 [18318732] J Neurosurg Pediatr. 2008 Mar;1(3):178; discussion 178-9 [18352760] J Neurosurg Pediatr. 2008 Mar;1(3):180-6 [18352761] NeuroRehabilitation. 2008;23(1):55-65 [18356589] Dev Med Child Neurol. 2003 Dec;45(12):829-32 [14667075] J Pediatr Orthop. 2004 Jan-Feb;24(1):45-53 [14676533] Lancet. 2004 Jan 17;363(9404):249-50 [14738817] Gait Posture. 2004 Jun;19(3):298-304 [15125919] Semin Pediatr Neurol. 2004 Mar;11(1):58-65 [15132254] Arch Phys Med Rehabil. 2004 Jul;85(7):1121-4 [15241761] J Pediatr Orthop. 2004 Sep-Oct;24(5):514-20 [15308901] Ann Neurol. 1977 Dec;2(6):460-5 [617588] Foot Ankle. 1983 Nov-Dec;4(3):149-59 [6642335] Adv Neurol. 1988;50:377-84 [3041760] J Pediatr Orthop. 1990 Jul-Aug;10(4):433-41 [2358477] J Bone Joint Surg Am. 1992 Oct;74(9):1347-57 [1429790] Childs Nerv Syst. 1995 Jan;11(1):21-2 [7712495] Instr Course Lect. 1996;45:475-90 [8727764] Pediatr Clin North Am. 1996 Oct;43(5):1135-50 [8858077] J Child Neurol. 1996 Nov;11 Suppl 1:S29-35 [8959459] J Pediatr Orthop. 1998 Jan-Feb;18(1):62-8 [9449104] J Hand Surg Br. 1998 Jun;23(3):340-3 [9665522] J Pediatr Orthop. 2000 Jan-Feb;20(1):93-103 [10641697] Dev Med Child Neurol. 2000 Feb;42(2):116-21 [10698329] J Pediatr Orthop. 2000 Jul-Aug;20(4):501-5 [10912608] Sports Med. 2000 Sep;30(3):207-19 [10999424] J Pediatr Orthop. 1998 Jan-Feb;18(1):95-101 [9449109] J Foot Ankle Surg. 1998 Jan-Feb;37(1):2-7; discussion 78 [9470109] Pediatr Neurosurg. 1997 Jul;27(1):40-4 [9486835] Muscle Nerve Suppl. 1997;6:S1-13 [9826979] Muscle Nerve Suppl. 1997;6:S61-91 [9826983] Muscle Nerve Suppl. 1997;6:S92-120 [9826984] J Biomech. 1999 May;32(5):493-501 [10327003] J Pediatr Orthop. 1999 May-Jun;19(3):366-75 [10344322] J Hand Surg Am. 1999 Sep;24(5):944-52 [10509272] J Am Med Assoc. 1952 Dec 6;150(14):1396-8 [12990436] J Bone Joint Surg Br. 2005 Apr;87(4):548-55 [15795209] Muscle Nerve. 2005 May;31(5):552-71 [15714511] Arch Phys Med Rehabil. 2005 May;86(5):932-9 [15895339] J Pediatr Orthop B. 2005 Jul;14(4):269-73 [15931031] J Pediatr Orthop B. 2005 Jul;14(4):274-9 [15931032] J Biomech. 2005 Nov;38(11):2181-9 [16154404] J Neurosurg. 2005 Mar;102(2 Suppl):157-62 [16156224] Phys Ther. 2005 Nov;85(11):1208-23 [16253049] J Hand Surg Am. 2006 Mar;31(3):483-90 [16516746] NeuroRx. 2006 Apr;3(2):217-24 [16554259] Dev Med Child Neurol. 2006 Jul;48(7):549-54 [16780622] Expert Rev Neurother. 2006 Jun;6(6):863-86 [16784410] Neurosurg Focus. 2006;21(2):e1 [16918222] Neurosurg Focus. 2006;21(2):e4 [16918225] Cochrane Database Syst Rev. 2008;(2):CD006676 [18425962] Am J Phys Med Rehabil. 2008 May;87(5):404-17 [17993987] Pediatr Phys Ther. 2008 Summer;20(2):173-8 [18480717] Am J Phys Med Rehabil. 2008 Jun;87(6):478-501 [18496250] J Child Neurol. 2008 Jun;23(6):628-34 [18281620] Clin Obstet Gynecol. 2008 Dec;51(4):816-28 [18981805] Clin J Sport Med. 2008 Nov;18(6):486-500 [19001882] Curr Sports Med Rep. 2008 Nov-Dec;7(6):353-8 [19005359] Pediatr Phys Ther. 2008 Winter;20(4):318-33 [19011522] Dev Med Child Neurol. 2008 Nov;50(11):808-14 [18811714] Dev Med Child Neurol. 2008 Dec;50(12):918-25 [19046185] J Neurol Phys Ther. 2009 Mar;33(1):27-44 [19265768] J Neural Transm (Vienna). 2009 Jun;116(6):777-84 [18726137] J Pediatr Orthop. 2001 Jan-Feb;21(1):89-94 [11176360] J Pediatr Orthop B. 2001 Jan;10(1):6-9 [11269813] J Pediatr Orthop B. 2001 Oct;10(4):265-74 [11727367] Dev Med Child Neurol. 2001 Nov;43(11):778-90 [11730153] J Pediatr Orthop. 2002 Mar-Apr;22(2):165-8 [11856922] Lancet. 2002 Mar 16;359(9310):907-8 [11918905] J Pediatr Orthop B. 2002 Apr;11(2):159-66 [11943992] Dev Med Child Neurol. 2002 Mar;44(3):158-63 [12005316] Arch Phys Med Rehabil. 2002 Aug;83(8):1157-64 [12161840] Dev Med Child Neurol. 2002 Jul;44(7):447-60 [12162382] Neuropediatrics. 2002 Aug;33(4):221-3 [12368994] Paediatr Drugs. 2003;5(1):11-23 [12513103] J Pediatr Orthop. 2003 Mar-Apr;23(2):150-4 [12604941] Arch Phys Med Rehabil. 2003 May;84(5):643-50 [12736875] Rehabil Nurs. 2003 May-Jun;28(3):92-5 [12747248] J Pediatr Orthop. 2003 Jul-Aug;23(4):535-41 [12826956] J Child Neurol. 2003 Sep;18 Suppl 1:S50-66 [13677571] Dev Med Child Neurol. 2003 Nov;45(11):758-62 [14580131] Dev Med Child Neurol. 2003 Nov;45(11):786-90 [14580136] Phys Ther. 2006 Oct;86(10):1406-25 [17012645] Phys Ther. 2006 Nov;86(11):1534-40 [17094192] Phys Ther. 2007 Mar;87(3):248-57 [17244693] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.pmr.2009.04.005 ER - TY - JOUR T1 - Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism. AN - 67535931; 19324854 AB - Lens epithelium-derived growth factor (LEDGF) is upregulated in response to stress and enhances the survival of neurons in the retina and optic nerve, as well as a wide range of other cells, such as fibroblasts and keratinocytes. Photoreceptor protection was investigated in the RCS rat retinal degeneration model after Ledgf delivery with an adeno-associated virus (AAV) and the mechanism of protection explored. Thirty-six RCS and nine P23H rats had bilateral subretinal injections of AAV-Ledgf in one eye and buffer in the contralateral eye as the control. Retinal function was evaluated 8 weeks later by the electroretinogram and compared with photoreceptor cell layer count. LEDGF mRNA and protein levels and mRNA levels of known stress-related factors were compared in treated and control retinas to explore the mechanism of LEDGF protection. Nine RCS rats were treated with adenovirus-heat shock protein 27 (Ad-HSP27) and examined for protection. Significant photoreceptor protection was evident functionally and morphologically in 65% to 100% of the RCS rats treated at early ages of up to 7 weeks. Cell protection was more prominent in the superior retinal hemisphere which has a slower natural degeneration rate in untreated eyes. Although many of the heat shock proteins and other stress-related genes showed significant elevation in the AAV-Ledgf-treated eyes, all increases were approximately twofold or less. Transduction of retinal cells with Ad-HSP27 also resulted in photoreceptor protection. AAV-Ledgf elicited no photoreceptor functional protection in P23H rhodopsin transgenic rat retina. Chronic LEDGF treatment via AAV-Ledgf administration gave successful protection of photoreceptors in the RCS rat retina and retarded cell death by about 2 weeks. Induction of heat shock proteins also gave photoreceptor protection. However, compelling evidence was not found that LEDGF protection was associated with upregulation of heat shock proteins. JF - Investigative ophthalmology & visual science AU - Raz-Prag, Dorit AU - Zeng, Yong AU - Sieving, Paul A AU - Bush, Ronald A AD - Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892-8021, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 3897 EP - 3906 VL - 50 IS - 8 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - HSP27 Heat-Shock Proteins KW - Psip1 protein, rat KW - RNA, Messenger KW - Transcription Factors KW - Index Medicus KW - Animals KW - HSP27 Heat-Shock Proteins -- metabolism KW - Cell Count KW - Transduction, Genetic KW - Cytoprotection KW - Animals, Genetically Modified KW - Reverse Transcriptase Polymerase Chain Reaction KW - Plasmids KW - Cell Survival KW - Rats KW - Mutagenesis, Site-Directed KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Rats, Mutant Strains KW - Genetic Vectors KW - HSP27 Heat-Shock Proteins -- genetics KW - Up-Regulation KW - Electroretinography KW - Retinal Degeneration -- physiopathology KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Gene Expression Regulation -- physiology KW - Transcription Factors -- metabolism KW - Retinal Degeneration -- therapy KW - Dependovirus -- genetics KW - Genetic Therapy -- methods KW - Adaptor Proteins, Signal Transducing -- genetics KW - Retinal Degeneration -- metabolism KW - Photoreceptor Cells, Vertebrate -- physiology KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67535931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Photoreceptor+protection+by+adeno-associated+virus-mediated+LEDGF+expression+in+the+RCS+rat+model+of+retinal+degeneration%3A+probing+the+mechanism.&rft.au=Raz-Prag%2C+Dorit%3BZeng%2C+Yong%3BSieving%2C+Paul+A%3BBush%2C+Ronald+A&rft.aulast=Raz-Prag&rft.aufirst=Dorit&rft.date=2009-08-01&rft.volume=50&rft.issue=8&rft.spage=3897&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-3153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2000 Mar 1;9(4):645-51 [10699188] Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2671-82 [16043837] FEBS Lett. 2000 May 4;473(1):1-5 [10802047] Exp Eye Res. 2000 May;70(5):693-705 [10870528] Nat Genet. 2000 Jul;25(3):306-10 [10888879] Nat Cell Biol. 2000 Sep;2(9):645-52 [10980706] Biotechniques. 2000 Sep;29(3):548-50, 552-4, 556 passim [10997270] Clin Experiment Ophthalmol. 2000 Oct;28(5):382-6 [11097287] Invest Ophthalmol Vis Sci. 2001 Apr;42(5):1087-95 [11274090] J Biol Chem. 2001 May 11;276(19):16059-63 [11274139] Biochem Biophys Res Commun. 2001 May 18;283(4):943-55 [11350077] J Virol. 2001 Jul;75(13):6199-203 [11390622] Mol Ther. 2002 Feb;5(2):125-32 [11829519] Prog Retin Eye Res. 2002 May;21(3):341-58 [12052388] Mol Vis. 2002 Sep 23;8:351-8 [12355064] Nat Genet. 2002 Oct;32(2):254-60 [12219089] J Neurosci. 2003 Jul 9;23(14):6050-7 [12853423] Autoimmun Rev. 2003 Sep;2(5):290-7 [12965181] Biol Cell. 2004 May;96(4):261-9 [15145530] Proc Natl Acad Sci U S A. 1968 Apr;59(4):1259-64 [4870861] Exp Eye Res. 1975 Aug;21(2):167-92 [1164921] Science. 1977 Sep 2;197(4307):1001-3 [560718] Science. 1988 Apr 1;240(4848):70-3 [2832944] Proc Natl Acad Sci U S A. 1990 Mar;87(6):2211-5 [2156265] Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3579-85 [16877432] Lancet. 2006 Nov 18;368(9549):1795-809 [17113430] Invest Ophthalmol Vis Sci. 2008 Jan;49(1):416-21 [18172120] Invest Ophthalmol Vis Sci. 2008 Jan;49(1):442-52 [18172124] Neurosci Lett. 2008 Apr 18;435(2):131-6 [18343576] Gene Ther. 2008 Jun;15(11):849-57 [18418417] Hum Gene Ther. 2001 Jan 1;12(1):71-6 [11177544] J Neural Transplant Plast. 1991;2(1):55-63 [1868118] Neuron. 1991 Dec;7(6):1043-51 [1722411] Neuron. 1991 Dec;7(6):1053-60 [1764242] Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503 [8516292] Neuron. 1993 Oct;11(4):595-605 [8398150] J Biol Chem. 1994 Oct 7;269(40):25143-9 [7929202] Neurosci Lett. 1995 Nov 17;200(2):85-8 [8614569] Gene Ther. 1997 Mar;4(3):244-51 [9135738] Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6916-21 [9192666] Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32 [9299445] Invest Ophthalmol Vis Sci. 1997 Dec;38(13):2857-63 [9418740] Nature. 1998 Feb 5;391(6667):587-91 [9468136] Nat Med. 1998 Aug;4(8):967-71 [9701253] J Cell Biol. 1962 Jul;14:73-109 [13887627] Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1168-75 [10752956] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-3153 ER - TY - JOUR T1 - Interrelationships of added sugars intake, socioeconomic status, and race/ethnicity in adults in the United States: National Health Interview Survey, 2005. AN - 67520644; 19631043 AB - The consumption of added sugars (eg, white sugar, brown sugar, and high-fructose corn syrup) displaces nutrient-dense foods in the diet. The intake of added sugars in the United States is excessive. Little is known about the predictors of added sugar intake. To examine the independent relationships of socioeconomic status and race/ethnicity with added sugar intake, and to evaluate the consistency of relationships using a short instrument to those from a different survey using more precise dietary assessment. Cross-sectional, nationally representative, interviewer-administered survey. Adults (aged > or = 18 years) participating in the 2005 US National Health Interview Survey Cancer Control Supplement responding to four added sugars questions (n=28,948). The intake of added sugars was estimated using validated scoring algorithms. Multivariate analysis incorporating sample weights and design effects was conducted. Least squares means and confidence intervals, and significance tests using Wald F statistics are presented. Analyses were stratified by sex and controlled for potential confounders. The intake of added sugars was higher among men than women and inversely related to age, educational status, and family income. Asian Americans had the lowest intake and Hispanics the next lowest intake. Among men, African Americans had the highest intake, although whites and American Indians/Alaskan Natives also had high intakes. Among women, African Americans and American Indians/Alaskan Natives had the highest intakes. Intake of added sugars was inversely related to educational attainment in whites, African Americans, Hispanic men, and American Indians/Alaskan Native men, but was unrelated in Asian Americans. These findings were generally consistent with relationships in National Health and Nutrition Examination Survey 2003-2004 (using one or two 24-hour dietary recalls). Race/ethnicity, family income, and educational status are independently associated with intake of added sugars. Groups with low income and education are particularly vulnerable to diets with high added sugars. Differences among race/ethnicity groups suggest that interventions to reduce intake of added sugars should be tailored. The National Health Interview Survey added sugars questions with accompanying scoring algorithms appear to provide an affordable and useful means of assessing relationships between various factors and added sugars intake. JF - Journal of the American Dietetic Association AU - Thompson, Frances E AU - McNeel, Timothy S AU - Dowling, Emily C AU - Midthune, Douglas AU - Morrissette, Meredith AU - Zeruto, Christopher A AD - National Cancer Institute Division of Cancer Control and Population Sciences, Applied Research Program, Risk Factor Monitoring and Methods Branch, 6130 Executive Blvd, EPN 4095A, Bethesda, MD 20892-7344, USA. thompsof@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1376 EP - 1383 VL - 109 IS - 8 KW - Dietary Sucrose KW - 0 KW - Sweetening Agents KW - Abridged Index Medicus KW - Index Medicus KW - Sweetening Agents -- adverse effects KW - Sweetening Agents -- administration & dosage KW - Nutritive Value KW - Humans KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- statistics & numerical data KW - Nutrition Surveys KW - Obesity -- epidemiology KW - Indians, North American -- statistics & numerical data KW - Age Distribution KW - Multivariate Analysis KW - Socioeconomic Factors KW - Obesity -- etiology KW - Cross-Sectional Studies KW - Hispanic Americans -- statistics & numerical data KW - Health Surveys KW - Surveys and Questionnaires KW - Sex Distribution KW - Asian Americans -- statistics & numerical data KW - Female KW - Male KW - Dietary Sucrose -- administration & dosage KW - Educational Status KW - Dietary Sucrose -- adverse effects KW - Social Class KW - Ethnic Groups -- statistics & numerical data KW - Income KW - Feeding Behavior -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67520644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=Interrelationships+of+added+sugars+intake%2C+socioeconomic+status%2C+and+race%2Fethnicity+in+adults+in+the+United+States%3A+National+Health+Interview+Survey%2C+2005.&rft.au=Thompson%2C+Frances+E%3BMcNeel%2C+Timothy+S%3BDowling%2C+Emily+C%3BMidthune%2C+Douglas%3BMorrissette%2C+Meredith%3BZeruto%2C+Christopher+A&rft.aulast=Thompson&rft.aufirst=Frances&rft.date=2009-08-01&rft.volume=109&rft.issue=8&rft.spage=1376&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=1878-3570&rft_id=info:doi/10.1016%2Fj.jada.2009.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Public Health. 2001;22:309-35 [11274524] J Am Diet Assoc. 2008 May;108(5):804-14 [18442504] J Am Diet Assoc. 1998 Feb;98(2):182-6, 189; quiz 187-8 [12515420] Obes Res. 2003 Nov;11(11):1325-32 [14627752] Am J Clin Nutr. 2004 Jan;79(1):6-16 [14684391] J Am Diet Assoc. 2004 May;104(5):771-8 [15127063] Br Dent J. 1992 Jan 11;172(1):7 [1736952] Am J Clin Nutr. 1995 Feb;61(2):423S-429S [7840088] Prev Med. 1997 Jul-Aug;26(4):508-15 [9245673] J Nutr. 1997 Oct;127(10 Suppl):2085S-2093S [9339174] Am J Health Promot. 1999 Mar-Apr;13(4):233-6, iii [10351854] Am J Clin Nutr. 2005 Jul;82(1 Suppl):265S-273S [16002835] Public Health Nutr. 2005 Oct;8(7):904-11 [16277807] Eur J Clin Nutr. 2006 Mar;60(3):434-6 [16306928] Am J Clin Nutr. 2006 Aug;84(2):274-88 [16895873] Obesity (Silver Spring). 2006 Oct;14(10):1825-31 [17062813] J Am Diet Assoc. 2007 Feb;107(2):223-34 [17258958] J Am Diet Assoc. 2007 Jun;107(6):942-50 [17524714] Epidemiol Rev. 2007;29:29-48 [17478442] Epidemiol Rev. 2007;29:160-71 [17591599] Food Chem Toxicol. 2007 Aug;45(8):1523-36 [17383789] J Am Diet Assoc. 2002 Nov;102(11):1621-30 [12449285] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jada.2009.05.002 ER - TY - JOUR T1 - Degreasing and risk of non-Hodgkin lymphoma. AN - 67497954; 19017696 AB - To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL). We analysed occupational data from a large population-based case-control study of NHL conducted in the USA. For participants reporting occupations with possible exposure to organic solvents, job-specific interview modules were administered to elicit in-depth information on solvent-related workplace tasks and other exposure-related factors (225 cases, 189 controls). Unconditional logistic regression models were fit to calculate odds ratios (ORs) and 95% CI for average frequency, maximal frequency and cumulative number of hours having performed each task. Individuals with jobs rated as unexposed to organic solvents in the workplace (180 cases, 213 controls) were used as a reference group. We observed an increased risk of NHL among subjects in the highest category of maximal degreasing frequency (>520 h/year: OR 2.1, 95% CI 0.9 to 4.9, trend test p = 0.02). We found similar associations for the highest levels of average frequency and, among men, cumulative number of hours. Other solvent-related tasks were not associated with NHL. Findings from this case-control analysis of solvent-related tasks suggest that frequent degreasing work may be associated with an elevated risk of NHL. JF - Occupational and environmental medicine AU - Purdue, M P AU - Severson, R K AU - Colt, J S AU - Stewart, P AU - De Roos, A J AU - Cerhan, J R AU - Cozen, W AU - Davis, S AU - Hartge, P AU - Schenk, M AU - Blair, A AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, 6120 Executive Blvd, Bethesda, MD 20892, USA. purduem@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 557 EP - 560 VL - 66 IS - 8 KW - Solvents KW - 0 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Solvents -- toxicity KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67497954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Degreasing+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Purdue%2C+M+P%3BSeverson%2C+R+K%3BColt%2C+J+S%3BStewart%2C+P%3BDe+Roos%2C+A+J%3BCerhan%2C+J+R%3BCozen%2C+W%3BDavis%2C+S%3BHartge%2C+P%3BSchenk%2C+M%3BBlair%2C+A&rft.aulast=Purdue&rft.aufirst=M&rft.date=2009-08-01&rft.volume=66&rft.issue=8&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.040386 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-28 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2002 May;44(5):469-74 [12024692] Occup Environ Med. 2002 Sep;59(9):575-93; discussion 594 [12205230] Int J Occup Environ Health. 2004 Jan-Mar;10(1):13-21 [15070021] Int J Cancer. 2004 Aug 10;111(1):76-80 [15185346] Am J Ind Med. 1993 Feb;23(2):301-12 [8427258] Occup Environ Med. 2009 Jan;66(1):23-31 [18805886] Int J Cancer. 1996 Aug 7;67(4):498-503 [8759607] Am Ind Hyg Assoc J. 1998 Jan;59(1):39-44 [9438334] Occup Environ Med. 2006 Jan;63(1):17-26 [16361401] Occup Environ Med. 2006 Sep;63(9):597-607 [16644896] Am J Epidemiol. 2008 Feb 1;167(3):350-61 [17989060] Am J Ind Med. 1995 Jun;27(6):817-35 [7645576] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.040386 ER - TY - JOUR T1 - Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. AN - 67497463; 19460945 AB - Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP-induced hepatotoxicity, mice humanized for PXR and CYP3A4 (TgCYP3A4/hPXR) were treated with APAP and rifampicin. Human PXR activation and CYP3A4 induction enhanced APAP-induced hepatotoxicity as revealed by hepatic alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities elevated in serum, and hepatic necrosis after coadministration of rifampicin and APAP, compared with APAP administration alone. In contrast, hPXR mice, wild-type mice, and Pxr-null mice exhibited significantly lower ALT/AST levels compared with TgCYP3A4/hPXR mice after APAP administration. Toxicity was coincident with depletion of hepatic glutathione and increased production of hydrogen peroxide, suggesting increased oxidative stress upon hPXR activation. Moreover, mRNA analysis demonstrated that CYP3A4 and other PXR target genes were significantly induced by rifampicin treatment. Urinary metabolomic analysis indicated that cysteine-APAP and its metabolite S-(5-acetylamino-2-hydroxyphenyl)mercaptopyruvic acid were the major contributors to the toxic phenotype. Quantification of plasma APAP metabolites indicated that the APAP dimer formed coincident with increased oxidative stress. In addition, serum metabolomics revealed reduction of lysophosphatidylcholine in the APAP-treated groups. These findings demonstrated that human PXR is involved in regulation of APAP-induced toxicity through CYP3A4-mediated hepatic metabolism of APAP in the presence of PXR ligands. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Cheng, Jie AU - Ma, Xiaochao AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1611 EP - 1621 VL - 37 IS - 8 KW - Analgesics, Non-Narcotic KW - 0 KW - Anti-Bacterial Agents KW - Biomarkers KW - Lysophosphatidylcholines KW - RNA, Messenger KW - Receptors, Steroid KW - acetaminophen-cysteine conjugate KW - pregnane X receptor KW - Acetaminophen KW - 362O9ITL9D KW - Hydrogen Peroxide KW - BBX060AN9V KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Glutathione -- metabolism KW - Humans KW - Hydrogen Peroxide -- metabolism KW - Principal Component Analysis KW - Mice KW - Lysophosphatidylcholines -- blood KW - Liver Diseases -- enzymology KW - Cysteine -- urine KW - Mice, Transgenic KW - RNA, Messenger -- biosynthesis KW - Metabolomics KW - Mice, Knockout KW - Aspartate Aminotransferases -- blood KW - Necrosis KW - Alanine Transaminase -- blood KW - Biotransformation KW - Liver Diseases -- pathology KW - Oxidative Stress -- drug effects KW - Enzyme Induction KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Liver -- enzymology KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury KW - Acetaminophen -- urine KW - Receptors, Steroid -- deficiency KW - Anti-Bacterial Agents -- toxicity KW - Cytochrome P-450 CYP3A -- genetics KW - Analgesics, Non-Narcotic -- metabolism KW - Rifampin -- toxicity KW - Liver -- drug effects KW - Analgesics, Non-Narcotic -- toxicity KW - Cytochrome P-450 CYP3A -- biosynthesis KW - Receptors, Steroid -- genetics KW - Acetaminophen -- metabolism KW - Acetaminophen -- toxicity KW - Receptors, Steroid -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67497463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Rifampicin-activated+human+pregnane+X+receptor+and+CYP3A4+induction+enhance+acetaminophen-induced+toxicity.&rft.au=Cheng%2C+Jie%3BMa%2C+Xiaochao%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Cheng&rft.aufirst=Jie&rft.date=2009-08-01&rft.volume=37&rft.issue=8&rft.spage=1611&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.109.027565 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2002 Oct 11;298(5592):422-4 [12376703] Ann Med. 2003;35(3):172-82 [12822739] Prostaglandins Other Lipid Mediat. 2003 Oct;72(1-2):51-71 [14626496] Clin Pharmacokinet. 2003;42(15):1331-57 [14674787] Drug Metab Dispos. 2004 Jan;32(1):35-42 [14709618] Biochem Biophys Res Commun. 1988 Jul 29;154(2):803-8 [3401237] Arch Biochem Biophys. 1989 Jun;271(2):270-83 [2729995] Histochemistry. 1991;95(4):319-28 [1708749] Annu Rev Pharmacol Toxicol. 1993;33:435-65 [8494347] J Biol Chem. 1996 May 17;271(20):12063-7 [8662637] Crit Rev Biochem Mol Biol. 1995;30(6):445-600 [8770536] Adverse Drug React Toxicol Rev. 1997 Mar;16(1):9-14 [9192054] J Gastroenterol Hepatol. 1997 Oct;12(9-10):S242-50 [9407344] Cell. 1998 Jan 9;92(1):73-82 [9489701] Chem Res Toxicol. 1998 Apr;11(4):295-301 [9548799] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] Toxicol Appl Pharmacol. 1998 Sep;152(1):193-9 [9772215] Turk J Pediatr. 2007 Jan-Mar;49(1):75-6 [17479648] Drug Metab Dispos. 2007 Jul;35(7):1223-31 [17392391] Joint Bone Spine. 2007 Jul;74(4):324-9 [17590367] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Expert Rev Mol Diagn. 2007 Sep;7(5):511-7 [17892360] J Biochem Mol Toxicol. 2007;21(4):169-75 [17936930] Pharmacotherapy. 2007 Nov;27(11):1473-82 [17963456] J Biol Chem. 2008 Feb 22;283(8):4543-59 [18093979] Toxicology. 2008 Mar 20;245(3):194-205 [18291570] J Med Toxicol. 2008 Mar;4(1):2-6 [18338302] Curr Drug Metab. 2008 May;9(4):310-22 [18473749] Adv Chronic Kidney Dis. 2008 Jul;15(3):222-34 [18565474] Mutagenesis. 2008 Jul;23(4):299-308 [18388359] Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):895-908 [18624678] Dev Biol. 2008 Aug 1;320(1):1-11 [18555213] BMB Rep. 2008 Aug 31;41(8):560-7 [18755070] Biochem Biophys Res Commun. 2008 Nov 21;376(3):584-9 [18801337] Drug Metab Dispos. 2008 Dec;36(12):2506-12 [18799805] Chem Res Toxicol. 2009 Apr;22(4):699-707 [19256530] Cell Biol Toxicol. 2009 Jun;25(3):265-74 [18496758] BMJ. 2007 Jan 27;334(7586):186-7 [17255610] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] IUBMB Life. 1999 Jul;48(1):41-7 [10791914] Toxicol Sci. 2000 Oct;57(2):338-44 [11006363] Drug Metab Dispos. 2000 Dec;28(12):1397-400 [11095574] Annu Rev Pharmacol Toxicol. 2002;42:1-23 [11807162] Endocr Rev. 2002 Oct;23(5):687-702 [12372848] Genes Dev. 1998 Oct 15;12(20):3195-205 [9784494] Toxicol Appl Pharmacol. 1998 Nov;153(1):102-8 [9875304] Toxicol Sci. 2004 Dec;82(2):374-80 [15456926] Trends Biochem Sci. 2005 Jan;30(1):5-7 [15653318] Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):85-98 [15720241] Arch Pharm Res. 2005 Mar;28(3):249-68 [15832810] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] Toxicol Rev. 2005;24(2):131-43 [16180933] Drug Metab Dispos. 2005 Dec;33(12):1827-36 [16141365] Anal Chem. 2006 Jan 15;78(2):567-74 [16408941] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] J Biol Chem. 2006 Apr 7;281(14):9127-36 [16467307] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.109.027565 ER - TY - JOUR T1 - A 21st century paradigm for evaluating the health hazards of nanoscale materials? AN - 67478391; 19468057 AB - Over the past 5 years we have seen an increase in the attention focused on the assessment of the potential health risk posed by nanoscale materials. The diversity of these materials with respect to size, composition, and surface properties, and the rapid pace of their development and commercialization, poses significant challenges to traditional toxicity testing paradigms. At the same time the potential use of new high throughput "predictive "toxicity" strategies, such as that envisioned in the recent NRC report "Toxicity Testing in the 21st Century," have emerged as possible solutions to deal with the issue of how to assess the safety of the thousands of chemicals to which humans are potentially exposed. In this forum article we discuss how in some respects, the emergence of diverse engineered nanomaterials offers a tailor-made test case for the application of a new paradigm for assessing human heath risks. However, although this approach may have merit in the study of some specific nanomaterials, this approach does not consider the complexity involved in utilizing in vitro cell culture toxicology methods to evaluate the potential hazard of the wide array of current and future engineered nanomaterials. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Walker, Nigel J AU - Bucher, John R AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. walker3@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 251 EP - 254 VL - 110 IS - 2 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Animals KW - History, 21st Century KW - Government Regulation KW - Reproducibility of Results KW - Humans KW - Cell Culture Techniques KW - National Academy of Sciences (U.S.) KW - Guidelines as Topic KW - Risk Assessment KW - Hazardous Substances -- adverse effects KW - Public Health -- legislation & jurisprudence KW - Hazardous Substances -- pharmacokinetics KW - Toxicity Tests -- history KW - Toxicity Tests -- methods KW - Nanoparticles -- history KW - Nanoparticles -- adverse effects KW - Hazardous Substances -- history KW - Public Health -- history KW - Public Health -- standards KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67478391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=A+21st+century+paradigm+for+evaluating+the+health+hazards+of+nanoscale+materials%3F&rft.au=Walker%2C+Nigel+J%3BBucher%2C+John+R&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2009-08-01&rft.volume=110&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-17 N1 - Date created - 2009-07-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2008 Feb 15;319(5865):906-7 [18276874] Toxicol Sci. 2008 Jan;101(1):4-21 [17602205] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7387-92 [18492802] Science. 2008 Aug 22;321(5892):1036-7 [18719262] Toxicol Sci. 2009 Feb;107(2):324-30 [19074763] Environ Sci Technol. 2009 May 1;43(9):3030-4 [19534109] J Pharm Sci. 2001 Dec;90(12):1927-36 [11745751] Science. 2003 Apr 11;300(5617):243 [12690169] Toxicol Sci. 2004 Jan;77(1):126-34 [14514958] Toxicol Sci. 2004 Jan;77(1):117-25 [14514968] Environ Health Perspect. 2005 Jul;113(7):823-39 [16002369] Science. 2006 Feb 3;311(5761):622-7 [16456071] Sci STKE. 2006 Mar 21;2006(327):pe14 [16552091] Nature. 2006 Nov 16;444(7117):267-9 [17108940] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8691-6 [17485668] Environ Health Perspect. 2007 Jun;115(6):A290 [17589571] Toxicol Sci. 2008 Feb;101(2):183-5 [18300382] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp106 ER - TY - JOUR T1 - Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. AN - 67463287; 19341726 AB - Expression of STAT3/pSTAT3 in colorectal cancer (CRC) patients of Indian origin was studied to assess its significance in early detection and apoptosis regulation. Colorectal tissues with malignant lesions were STAT3/pSTAT3 positive in 66% of the cases and among these positive cases, well differentiated, moderately differentiated and poorly differentiated cancers were 86%, 60% and 0% respectively. All CRC specimens studied were immunoreactive with anti-carcinoembryonic antigen antibody. Cells purified from CRC tissues exhibited greater STAT3/pSTAT3 reactivity than peripheral blood mononuclear cells (PBMC) from healthy individuals, which served as control. apoptotic index (AI) was comparatively low in tissue specimens with STAT3/pSTAT3 expression. CRC cells with a comparatively less number of apoptotic cells, expressed a minimum number of Caspase-3 positive cells (4.73%), in comparison to healthy-PBMC (12.63%). CRC cells with high STAT3/pSTAT3 staining had cells with greater percentage of Bcl2 reactivity (23.05%), but less positivity with Caspase3 antibody (2.05%). Overall data suggests that CRC population was STAT3/pSTAT3 immunoreactive in a stage specific manner and STAT3 protects cancerous colorectal epithelial cells from apoptosis. Bcl-2, Cyclin D1 and Caspase-3 control the activity of apoptosis regulator, STAT3. JF - Experimental and molecular pathology AU - Baral, Rathindranath AU - Bose, Anamika AU - Ray, Chinmoyee AU - Paul, Sonali AU - Pal, Smarajit AU - Haque, Enamul AU - Mishra, Bhagawan AU - Pal, Debolina AU - Nagpal, Jatin Kumar AU - Panda, Chinmay Kumar AU - Das, Bibhu Ranjan AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India. rbaral2@hotmail.com Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 36 EP - 41 VL - 87 IS - 1 KW - Carcinoembryonic Antigen KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - STAT3 Transcription Factor KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Carcinoembryonic Antigen -- metabolism KW - Young Adult KW - Signal Transduction -- physiology KW - Tumor Cells, Cultured KW - Humans KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Adult KW - Middle Aged KW - Male KW - Female KW - Caspase 3 -- metabolism KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- metabolism KW - Apoptosis -- physiology KW - Colorectal Neoplasms -- physiopathology KW - STAT3 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67463287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+molecular+pathology&rft.atitle=Association+of+early+phase+of+colorectal+carcinogenesis+with+STAT3+activation+and+its+relevance+in+apoptosis+regulation.&rft.au=Baral%2C+Rathindranath%3BBose%2C+Anamika%3BRay%2C+Chinmoyee%3BPaul%2C+Sonali%3BPal%2C+Smarajit%3BHaque%2C+Enamul%3BMishra%2C+Bhagawan%3BPal%2C+Debolina%3BNagpal%2C+Jatin+Kumar%3BPanda%2C+Chinmay+Kumar%3BDas%2C+Bibhu+Ranjan&rft.aulast=Baral&rft.aufirst=Rathindranath&rft.date=2009-08-01&rft.volume=87&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Experimental+and+molecular+pathology&rft.issn=1096-0945&rft_id=info:doi/10.1016%2Fj.yexmp.2009.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yexmp.2009.03.002 ER - TY - JOUR T1 - Halofuginone mediated protection against radiation-induced leg contracture. AN - 67449897; 19578745 AB - Fibrosis of normal tissues often accompanies radiation treatment of cancer. Activation of the transforming growth factor-beta (TGF-beta) signaling pathway is thought to play a major role in radiation-induced fibrosis and has prompted the development and assessment of low molecular weight inhibitors of the pathway. Previous studies with halofuginone have shown it to inhibit TGF-beta signaling in vitro and protect mice from radiation-induced leg contraction (a model for soft tissue fibrosis). The current study confirms these findings for HaCaT cells stimulated with exogenous TGF-beta treatment. Reducing the halifuginone treatment from 7 days/week (used previously) to 5 days/week post-radiation exposure provided significant protection against radiation-induced leg contraction in mice 3 and 4 months post-radiation treatment. Halofuginone treatment was shown to attenuate TGF-beta signaling molecules taken from irradiated skin including TGF-betaRII, pSmad3, Smad7, and TSP1. The latter, TSP1, a co-activator of TGF-beta may serve as a suitable biomarker for monitoring the efficacy of halofuginone should it be evaluated in a clinical setting for protection against radiation-induced fibrosis. JF - International journal of oncology AU - Ishii, Hisanari AU - Choudhuri, Rajani AU - Mathias, Askale AU - Sowers, Anastasia L AU - Flanders, Kathleen C AU - Cook, John A AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1002, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 315 EP - 319 VL - 35 IS - 2 SN - 1019-6439, 1019-6439 KW - Piperidines KW - 0 KW - Quinazolinones KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - transforming growth factor-beta type II receptor KW - EC 2.7.11.30 KW - halofuginone KW - L31MM1385E KW - Index Medicus KW - Leg KW - Animals KW - Receptors, Transforming Growth Factor beta -- physiology KW - Humans KW - Signal Transduction -- drug effects KW - Mice, Inbred C3H KW - Mice KW - Protein-Serine-Threonine Kinases -- physiology KW - Female KW - Cell Line KW - Piperidines -- pharmacology KW - Fibrosis -- prevention & control KW - Transforming Growth Factor beta -- antagonists & inhibitors KW - Radiotherapy -- adverse effects KW - Quinazolinones -- pharmacology KW - Contracture -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67449897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Halofuginone+mediated+protection+against+radiation-induced+leg+contracture.&rft.au=Ishii%2C+Hisanari%3BChoudhuri%2C+Rajani%3BMathias%2C+Askale%3BSowers%2C+Anastasia+L%3BFlanders%2C+Kathleen+C%3BCook%2C+John+A%3BMitchell%2C+James+B&rft.aulast=Ishii&rft.aufirst=Hisanari&rft.date=2009-08-01&rft.volume=35&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):277-90 [10802350] Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):829-37 [18411002] Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):937-43 [11958886] Nephrol Dial Transplant. 2003 Jul;18(7):1241-5 [12808154] Cell. 2003 Jun 13;113(6):685-700 [12809600] Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):563-72 [12957270] Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1235-41 [15001268] J Biol Chem. 2004 Apr 9;279(15):15167-76 [14732719] Int J Radiat Oncol Biol Phys. 1984 Jul;10(7):1053-61 [6746346] J Cell Biol. 1988 Mar;106(3):761-71 [2450098] Radiat Res. 1990 Apr;122(1):77-85 [2181527] Cancer Res. 1993 Sep 1;53(17):3880-6 [8358713] Br J Radiol. 1995 Mar;68(807):331-3 [7735779] Int J Radiat Biol. 1996 Sep;70(3):351-60 [8800206] FASEB J. 1997 Oct;11(12):991-1002 [9337152] Radiother Oncol. 2005 Apr;75(1):48-53 [15948265] Biochim Biophys Acta. 2006 Apr;1765(2):178-88 [16406676] Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):876-81 [16751069] J Clin Oncol. 2007 Aug 1;25(22):3259-65 [17577015] Int J Radiat Biol. 2007 Nov-Dec;83(11-12):803-11 [18058368] Am J Pathol. 2002 Mar;160(3):1057-68 [11891202] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical presentation of mania compared with depression: data from a geriatric clinic in India. AN - 67448605; 19493381 AB - This retrospective chart review evaluated a comparison of the clinical profiles of older outpatients having mania and those with unipolar depression. The charts of elderly outpatients with mania and unipolar depression in tertiary care settings were reviewed and relevant information incorporated regarding clinical presentation, past and family history of affective disorder, treatment history and previous psychiatric and neurological history. Charts for 30 patients with mania (23 men and 7 women with mean (+/-SD) age of 68.5(+/- 5.75 years) and 92 with depression (47 men and 45 women with mean (+/-SD) age of 68.18 (+/-6.0 years) were evaluated. Fifteen patients (50%) with manic episodes had psychotic symptoms in the form of delusions and hallucinations while only 33 (35.8%) depressed patients had psychotic symptoms. One-third of manic patients received mood stabilizers at index visit. More than half (n = 16; 53.3%) of the patients in the mania group were prescribed antipsychotic medications. On cognitive functions, patients with manic episodes scored poorly compared with those with depression. These findings suggest that mania in the elderly is a severe form of affective disorder with respect to psychotic and cognitive symptoms. Conclusions from this study are limited due to its retrospective design. Further studies in this area are warranted. JF - International psychogeriatrics AU - Prakash, Om AU - Kumar, Channaveerachari Naveen AU - Shivakumar, P T AU - Bharath, Srikala AU - Varghese, Mathew AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. op@nimhans.kar.nic.in Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 764 EP - 767 VL - 21 IS - 4 SN - 1041-6102, 1041-6102 KW - Index Medicus KW - Age Factors KW - Hallucinations -- diagnosis KW - Delusions -- psychology KW - Humans KW - Aged KW - Comorbidity KW - India KW - Hallucinations -- genetics KW - Aged, 80 and over KW - Cognition Disorders -- genetics KW - Substance-Related Disorders -- genetics KW - Male KW - Outpatient Clinics, Hospital KW - Hallucinations -- psychology KW - Educational Status KW - Cognition Disorders -- diagnosis KW - Diagnosis, Differential KW - Sex Factors KW - Delusions -- genetics KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- diagnosis KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Delusions -- diagnosis KW - Middle Aged KW - Statistics as Topic KW - Cognition Disorders -- psychology KW - Female KW - Poverty -- statistics & numerical data KW - Poverty -- psychology KW - Bipolar Disorder -- diagnosis KW - Psychotic Disorders -- psychology KW - Depressive Disorder -- psychology KW - Psychotic Disorders -- genetics KW - Depressive Disorder -- diagnosis KW - Bipolar Disorder -- genetics KW - Depressive Disorder -- genetics KW - Bipolar Disorder -- psychology KW - Developing Countries KW - Psychotic Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67448605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+psychogeriatrics&rft.atitle=Clinical+presentation+of+mania+compared+with+depression%3A+data+from+a+geriatric+clinic+in+India.&rft.au=Prakash%2C+Om%3BKumar%2C+Channaveerachari+Naveen%3BShivakumar%2C+P+T%3BBharath%2C+Srikala%3BVarghese%2C+Mathew&rft.aulast=Prakash&rft.aufirst=Om&rft.date=2009-08-01&rft.volume=21&rft.issue=4&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=International+psychogeriatrics&rft.issn=10416102&rft_id=info:doi/10.1017%2FS1041610209009466 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-17 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S1041610209009466 ER - TY - JOUR T1 - Endocannabinoids and cardiac contractile function: pathophysiological implications. AN - 67431450; 19569260 AB - Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atherosclerosis, myocardial infarction, hemorrhagic or septic shock, heart failure and cardiovascular complications of liver cirrhosis. Even though the benefit of chronic cannabinoid 1 (CB1) receptor blockade with the currently available compounds may not outweigh the risks in chronic conditions such as obesity, modulation of the ECS may hold great therapeutic promise in various cardiovascular conditions/disorders. In this review we will discuss recent advances in understanding the role of CB1 receptors and endocannabinoids in the regulation of cardiac function in cirrhotic cardiomyopathy and in doxorubicin-induced heart failure. JF - Pharmacological research AU - Bátkai, Sándor AU - Pacher, Pál AD - Phenotyping Core, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, 5625 Fishers Lane, MSC-9413, Bethesda, MD 20892-9413, USA. sbatkai@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 99 EP - 106 VL - 60 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Cannabinoid Receptor Modulators KW - Endocannabinoids KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Animals KW - Doxorubicin -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Humans KW - Heart Failure -- chemically induced KW - Cardiomyopathies -- physiopathology KW - Liver Cirrhosis -- physiopathology KW - Cardiovascular Diseases -- physiopathology KW - Heart Failure -- physiopathology KW - Cannabinoid Receptor Modulators -- physiology KW - Myocardial Contraction -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67431450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=Endocannabinoids+and+cardiac+contractile+function%3A+pathophysiological+implications.&rft.au=B%C3%A1tkai%2C+S%C3%A1ndor%3BPacher%2C+P%C3%A1l&rft.aulast=B%C3%A1tkai&rft.aufirst=S%C3%A1ndor&rft.date=2009-08-01&rft.volume=60&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=1096-1186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-02 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Pharmacol. 2008 Jan;153(2):252-62 [18026124] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704 [18263732] Br J Pharmacol. 2008 Mar;153(5):1003-10 [18157162] Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G850-4 [18239059] J Neuroendocrinol. 2008 May;20 Suppl 1:47-52 [18426499] Nat Rev Drug Discov. 2008 May;7(5):438-55 [18446159] Nat Protoc. 2008;3(9):1422-34 [18772869] Hypertension. 2008 Oct;52(4):601-7 [18779440] Biochem Biophys Res Commun. 2008 Dec 26;377(4):1248-52 [18996082] Congest Heart Fail. 2008 Nov-Dec;14(6):330-4 [19076859] Br J Pharmacol. 2009 Jan;156(1):94-104 [19133994] Trends Pharmacol Sci. 2009 Jan;30(1):1-7 [19042036] J Mol Cell Cardiol. 2009 May;46(5):612-20 [19162037] Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83 [19286953] Gastroenterology. 2009 Jul;137(1):341-9 [19208344] Biochem J. 2000 Mar 15;346 Pt 3:835-40 [10698714] Nat Med. 2001 Jul;7(7):827-32 [11433348] Arch Biochem Biophys. 2001 Sep 15;393(2):321-8 [11556820] Bull Exp Biol Med. 2001 Jun;131(6):523-5 [11586395] J Am Coll Cardiol. 2001 Dec;38(7):2048-54 [11738314] Gastroenterology. 2002 Jan;122(1):85-93 [11781284] J Pharmacol Exp Ther. 2002 Mar;300(3):862-7 [11861791] Pharmacol Ther. 2002 Aug;95(2):191-202 [12182966] Chem Phys Lipids. 2002 Dec 31;121(1-2):45-56 [12505689] Life Sci. 2003 Mar 7;72(16):1859-70 [12586223] Circulation. 2003 Feb 18;107(6):896-904 [12591762] J Cardiovasc Pharmacol. 2003 Apr;41(4):657-64 [12658069] Br J Pharmacol. 2003 Apr;138(7):1251-8 [12711625] Br J Pharmacol. 2003 Jun;139(4):805-15 [12813004] J Clin Invest. 2003 Aug;112(3):423-31 [12897210] Cell Death Differ. 2003 Sep;10(9):946-55 [12934069] J Biol Chem. 2003 Nov 7;278(45):45034-9 [12949078] Oncol Rep. 2004 Feb;11(2):505-8 [14719091] J Leukoc Biol. 2004 Mar;75(3):453-9 [14657208] J Physiol. 2004 Jul 15;558(Pt 2):647-57 [15121805] Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H595-600 [15059774] Circulation. 2004 Oct 5;110(14):1996-2002 [15451779] Liver Int. 2004 Oct;24(5):477-83 [15482346] Science. 1977 Jul 8;197(4299):165-7 [877547] N Engl J Med. 1981 Jul 16;305(3):139-53 [7017406] Hepatology. 1996 Aug;24(2):451-9 [8690419] Hypertension. 1996 Oct;28(4):682-6 [8843898] Nature. 1997 Dec 4;390(6659):518-21 [9394002] FASEB J. 1998 Aug;12(11):1035-44 [9707176] Eur J Pharmacol. 1998 Oct 16;359(1):1-18 [9831287] J Mol Med (Berl). 1998 Nov-Dec;76(12):824-36 [9846953] Br J Pharmacol. 1999 Jan;126(2):457-66 [10077239] Nature. 1999 Jul 29;400(6743):452-7 [10440374] J Clin Invest. 1953 Oct;32(10):1025-33 [13096569] Gut. 2005 Apr;54(4):522-7 [15753538] Hepatology. 2005 May;41(5):1085-95 [15841466] J Clin Invest. 2005 May;115(5):1298-305 [15864349] Pharmacol Ther. 2005 May;106(2):133-45 [15866316] Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H533-41 [15821037] Diabetes. 2005 Oct;54(10):2838-43 [16186383] Br J Pharmacol. 2005 Oct;146(3):315-23 [16025138] Science. 2005 Oct 14;310(5746):329-32 [16224028] Br J Pharmacol. 2005 Nov;146(6):809-16 [16158067] Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G328-34 [16407591] Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646] Handb Exp Pharmacol. 2005;(168):53-79 [16596771] Handb Exp Pharmacol. 2005;(168):599-625 [16596789] Nat Clin Pract Gastroenterol Hepatol. 2006 Jun;3(6):329-37 [16741552] Nat Med. 2006 Jun;12(6):671-6 [16715087] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] J Mol Cell Cardiol. 2006 Sep;41(3):389-405 [16879835] Br J Pharmacol. 2006 Dec;149(7):898-908 [17043671] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Prog Cardiovasc Dis. 2007 Mar-Apr;49(5):330-52 [17329180] Clin Sci (Lond). 2007 May;112(10):533-42 [17176248] Mol Pharmacol. 2007 Jun;71(6):1445-56 [17327463] FASEB J. 2007 Jun;21(8):1788-800 [17327359] Br J Pharmacol. 2007 Jun;151(4):427-40 [17450170] J Am Coll Cardiol. 2007 Aug 7;50(6):528-36 [17678736] FASEB J. 2007 Sep;21(11):2798-806 [17440119] Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1689-95 [17557913] Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8 [17660390] Br J Pharmacol. 2007 Nov;152(5):594-601 [17618306] Br J Pharmacol. 2007 Nov;152(5):825-31 [17704827] Neuropharmacology. 2008 Jan;54(1):1-7 [17631919] J Hypertens. 2008 Feb;26(2):357-67 [18192851] Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G9-G12 [17975129] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Age-appropriate use of human papillomavirus vaccines in the U.S. AN - 67430233; 19464729 AB - Cervical infections by approximately 15 cancer-associated (carcinogenic) human papillomavirus (HPV) genotypes cause virtually all cervical cancer and its immediate precursor lesions worldwide. Prophylactic vaccines against human papillomavirus (HPV) types HPV16 and HP18, which cause 70% of cervical cancer worldwide, hold great promise for reducing the burden of cervical cancer worldwide. However, current HPV vaccines prevent future infections and related cervical abnormalities and do not treat pre-existing HPV infections. In the U.S., HPV vaccine introduction should be considered in the context of a very successful cervical cancer screening program that has reduced the rates of cervical cancer by 75% or more. Thus, HPV vaccines will only prevent an incremental number of additional cervical cancers in the U.S. The introduction of HPV vaccines can also prevent other HPV-related sequelae, most importantly cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3), which precede the development of cervical cancer and require clinical follow-up and treatment. Examining data from 7 clinical centers in the U.S., the median age of CIN2/3 is typically between 25 and 30 years of age in 2007; if screen-detected CIN2/3 develops on average 5-10 years after the causal infection is acquired, HPV vaccination will only prevent a significant proportion of CIN2/3 if it is given to women before the age of 26 and more so if given to women 18 and younger. It is increasingly evident that prophylactic HPV vaccines will provide the greatest public health or population benefit only when delivered to adolescent, mostly HPV-naive women. JF - Gynecologic oncology AU - Castle, Philip E AU - Fetterman, Barbara AU - Akhtar, Israh AU - Husain, Mujtaba AU - Gold, Michael A AU - Guido, Richard AU - Glass, Andrew G AU - Kinney, Walter AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 365 EP - 369 VL - 114 IS - 2 KW - Papillomavirus Vaccines KW - 0 KW - Index Medicus KW - United States KW - Uterine Cervical Neoplasms -- prevention & control KW - Age Factors KW - Cervical Intraepithelial Neoplasia -- prevention & control KW - Humans KW - Papillomavirus Infections -- virology KW - Uterine Cervical Diseases -- virology KW - Papillomavirus Infections -- prevention & control KW - Human papillomavirus 18 -- immunology KW - Uterine Cervical Diseases -- prevention & control KW - Cervical Intraepithelial Neoplasia -- virology KW - Female KW - Human papillomavirus 16 -- immunology KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Vaccines -- immunology KW - Papillomavirus Vaccines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67430233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Age-appropriate+use+of+human+papillomavirus+vaccines+in+the+U.S.&rft.au=Castle%2C+Philip+E%3BFetterman%2C+Barbara%3BAkhtar%2C+Israh%3BHusain%2C+Mujtaba%3BGold%2C+Michael+A%3BGuido%2C+Richard%3BGlass%2C+Andrew+G%3BKinney%2C+Walter&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2009-08-01&rft.volume=114&rft.issue=2&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=1095-6859&rft_id=info:doi/10.1016%2Fj.ygyno.2009.04.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pathol. 1999 Sep;189(1):12-9 [10451482] J Infect Dis. 2008 May 15;197(10):1436-47 [18419547] Adv Data. 2005 Sep 15;(362):1-55 [16250464] CA Cancer J Clin. 2007 Jan-Feb;57(1):7-28 [17237032] JAMA. 2007 Feb 28;297(8):813-9 [17327523] MMWR Recomm Rep. 2007 Mar 23;56(RR-2):1-24 [17380109] Am J Clin Pathol. 2007 May;127(5):805-15 [17439841] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] N Engl J Med. 2007 May 10;356(19):1915-27 [17494925] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] Med J Aust. 2008 May 5;188(9):501-2 [18459918] Vaccine. 2008 Mar 14;26 Suppl 1:A12-5 [18642458] N Engl J Med. 2008 Aug 21;359(8):821-32 [18716299] Cancer. 2008 Nov 15;113(10 Suppl):3031-5 [18980285] J Infect Dis. 2009 Apr 1;199(7):936-44 [19236277] J Infect Dis. 2009 Apr 1;199(7):926-35 [19236279] Obstet Gynecol. 2009 Mar;113(3):595-600 [19300322] Br J Cancer. 2009 Apr 7;100(7):1184-90 [19293802] JAMA. 1994 Jun 15;271(23):1866-9 [8196145] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] J Natl Cancer Inst. 1993 Jun 16;85(12):958-64 [8388478] N Engl J Med. 2007 May 10;356(19):1928-43 [17494926] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Lancet. 2007 Jun 30;369(9580):2135-7 [17602733] Lancet. 2007 Jun 30;369(9580):2161-70 [17602732] JAMA. 2007 Aug 15;298(7):743-53 [17699008] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Int J Gynecol Pathol. 2007 Oct;26(4):441-6 [17885496] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] J Low Genit Tract Dis. 2007 Oct;11(4):201-22 [17917566] J Infect Dis. 2007 Nov 15;196(10):1447-54 [18008222] J Natl Cancer Inst. 2008 Mar 5;100(5):308-20 [18314477] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] J Infect Dis. 2005 Jun 1;191(11):1808-16 [15871112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygyno.2009.04.035 ER - TY - JOUR T1 - Changes in Female support Network Systems and Adaptation after Breast Cancer Diagnosis: Differences between Older and Younger Patients AN - 61728218; 200941216 AB - Purpose:NBThis study evaluates the changes in social networks of older and younger breast cancer patients over a 6-month period following their first diagnosis and how such modifications are associated with changes in the patients' mood state.NBDesign and Methods:NBNewly diagnosed breast cancer patients were interviewed shortly after their diagnosis and again 6 months later. Female support network members enumerated by patients were interviewed once within 3 months of the patients' initial interview.NBResults:NBFindings based on information for 149 network members of 26 patients indicate that members in older (> 51 years) patients' networks were less likely to be dropped at follow-up (odds ratio [OR] = 0.21, p = .04) compared with those in younger patients' networks. Network members who provided more support were less likely to be dropped by younger patients (OR = 0.42, p < .01). Decrease in network size was associated with decrease in mood disturbances among younger patients (Profile of Mood StateBipolar: B = 0. 35, p <.01).NBImplications:NBReducing the number of network members after cancer diagnosis may not necessarily lead to psychological distress, providing support for self-regulation of social network resources among cancer patients. Older patients' network members were more embedded in patients' networks, making it more stable over time. Identifying important network members (e.g., frequent support providers for younger patients and family members for older patients) and facilitating positive social interactions between these network members and patients may be beneficial. Adapted from the source document. JF - The Gerontologist AU - Ashida, Sato AU - Palmquist, Aunchalee E L AU - Basen-Engquist, Karen AU - Singletary, S Eva AU - Koehly, Laura M AD - Social & Behavioral Research Branch, National Human Genome Research Instit, Bethesda, MD ashidas@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 549 EP - 559 PB - Gerontological Society of America, Washington DC VL - 49 IS - 4 SN - 0016-9013, 0016-9013 KW - Social relationships, Social support, Cancer survivor, Social selectivity, Psychological adaptation KW - Breast Cancer KW - Social Networks KW - Social Support KW - Social Interaction KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61728218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Changes+in+Female+support+Network+Systems+and+Adaptation+after+Breast+Cancer+Diagnosis%3A+Differences+between+Older+and+Younger+Patients&rft.au=Ashida%2C+Sato%3BPalmquist%2C+Aunchalee+E+L%3BBasen-Engquist%2C+Karen%3BSingletary%2C+S+Eva%3BKoehly%2C+Laura+M&rft.aulast=Ashida&rft.aufirst=Sato&rft.date=2009-08-01&rft.volume=49&rft.issue=4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnp048 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Social Support; Breast Cancer; Social Networks; Social Interaction DO - http://dx.doi.org/10.1093/geront/gnp048 ER - TY - JOUR T1 - Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits AN - 57308156; 200922192 AB - Background. Although mental disorders have been shown to predict subsequent substance disorders, it is not known whether substance disorders could be cost-effectively prevented by large-scale interventions aimed at prior mental disorders. Although experimental intervention is the only way to resolve this uncertainty, a logically prior question is whether the associations of mental disorders with subsequent substance disorders are strong enough to justify mounting such an intervention. We investigated this question in this study using simulations to estimate the number of substance disorders that might be prevented under several hypothetical intervention scenarios focused on mental disorders. Method. Data came from the National Comorbidity Survey Replication (NCS-R), a nationally representative US household survey that retrospectively assessed lifetime history and age of onset of DSM-IV mental and substance disorders. Survival analysis using retrospective age-of-onset reports was used to estimate associations of mental disorders with subsequent substance dependence. Simulations based on the models estimated effect sizes in several hypothetical intervention scenarios. Results. Although successful intervention aimed at mental disorders might prevent some proportion of substance dependence, the number of cases of mental disorder that would have to be treated to prevent a single case of substance dependence is estimated to be so high that this would not be a cost-effective way to prevent substance dependence (in the range 76-177 for anxiety-mood disorders and 40-47 for externalizing disorders). Conclusions. Treatment of prior mental disorders would not be a cost-effective way to prevent substance dependence. However, prevention of substance dependence might be considered an important secondary outcome of interventions for early-onset mental disorders. Adapted from the source document. JF - Psychological Medicine AU - Glantz, M D AU - Anthony, J C AU - Berglund, P A AU - Degenhardt, L AU - Dierker, L AU - Kalaydjian, A AU - Merikangas, K R AU - Ruscio, A M AU - Swendsen, J AU - Kessler, R C AD - 6001 Executive Boulevard, Suite 5185, MSC 9589 Bethesda, MD 20892, USA mglantz@nida.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1365 EP - 1377 PB - Cambridge University Press, UK VL - 39 IS - 8 SN - 0033-2917, 0033-2917 KW - Mental disorders, prevention, substance dependence, treatment KW - Prevention KW - Interventions KW - Psychiatric disorders KW - Simulation KW - Cost effectiveness KW - Substance dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57308156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Mental+disorders+as+risk+factors+for+later+substance+dependence%3A+estimates+of+optimal+prevention+and+treatment+benefits&rft.au=Glantz%2C+M+D%3BAnthony%2C+J+C%3BBerglund%2C+P+A%3BDegenhardt%2C+L%3BDierker%2C+L%3BKalaydjian%2C+A%3BMerikangas%2C+K+R%3BRuscio%2C+A+M%3BSwendsen%2C+J%3BKessler%2C+R+C&rft.aulast=Glantz&rft.aufirst=M&rft.date=2009-08-01&rft.volume=39&rft.issue=8&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291708004510 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Psychiatric disorders; Substance dependency; Interventions; Cost effectiveness; Simulation; Prevention DO - http://dx.doi.org/10.1017/S0033291708004510 ER - TY - JOUR T1 - Sensory Motor and Functional Skills of Dizygotic Twins: One with Smith-Magenis Syndrome and a Twin Control AN - 57305051; 200923823 AB - Smith-Magenis syndrome (SMS), the result of an interstitial deletion within chromosome 17p11.2, is a disorder that may include minor dysmorphic features, brachydactyly, short stature, hypotonia, speech delays, cognitive deficits, signs of peripheral neuropathy, scoliosis, and neurobehavioral problems including sleep disturbances and maladaptive repetitive and self-injurious behaviors. Physical and occupational therapists provide services for children who have the syndrome, whose genetic disorder is frequently not identified or diagnosed before 1 year of age. A comprehensive physical and occupational therapy evaluation was completed in nonidentical twins with one having SMS, using the Sensory Profile; Brief Assessment of Motor Function (BAMF); Peabody Developmental Motor Scales, Second Edition (PDMS-2); and Pediatric Evaluation of Disability Inventory (PEDI). This provides a framework for conducting assessments to enhance early detection and interdisciplinary management with this specialized population. Adapted from the source document. JF - Physical and Occupational Therapy in Pediatrics AU - Smith, Michaele R AU - Hildenbrand, Hanna AU - Smith, Ann C M AD - Rehabilitation Medicine Department, National Institutes of Health (NIH) Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 239 EP - 257 PB - Informa Healthcare, New York NY VL - 29 IS - 3 SN - 0194-2638, 0194-2638 KW - Assessment KW - Twins KW - Motor performance KW - Sleep problems KW - Early warnings KW - Smith-Magenis syndrome KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57305051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+and+Occupational+Therapy+in+Pediatrics&rft.atitle=Sensory+Motor+and+Functional+Skills+of+Dizygotic+Twins%3A+One+with+Smith-Magenis+Syndrome+and+a+Twin+Control&rft.au=Smith%2C+Michaele+R%3BHildenbrand%2C+Hanna%3BSmith%2C+Ann+C+M&rft.aulast=Smith&rft.aufirst=Michaele&rft.date=2009-08-01&rft.volume=29&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Physical+and+Occupational+Therapy+in+Pediatrics&rft.issn=01942638&rft_id=info:doi/10.1080%2F01942630903028408 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Twins; Smith-Magenis syndrome; Assessment; Early warnings; Sleep problems; Motor performance DO - http://dx.doi.org/10.1080/01942630903028408 ER - TY - JOUR T1 - Measuring collaboration and integration activities in criminal justice and substance abuse treatment agencies AN - 57303243; 200922070 AB - Individuals with substance abuse problems who are involved in the criminal justice system frequently need community-based drug and alcohol abuse treatment and other services. To reduce the risk of relapse to illicit drugs and criminal recidivism, criminal justice agencies may need to establish collaborations with substance abuse treatment and other community-based service providers. Although there are many variations of interorganizational relationships, the nature of these interagency collaborations among justice agencies and treatment providers has received little systematic study. As a first step, we present an instrument to measure interagency collaboration and integration activities using items in the National Criminal Justice Treatment Practices Surveys conducted as part of the Criminal Justice Drug Abuse Treatment Studies (CJ-DATS). Collaboration and integration activities related to drug-involved offenders were examined between substance abuse treatment providers, correctional agencies, and the judiciary. The measurement scale reliably identified two levels of collaboration: less structured, informal networking and coordination and more structured and formalized levels of cooperation and collaboration. An illustration of the use of the systems integration tool is presented. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Fletcher, Bennett W AU - Lehman, Wayne E K AU - Wexler, Harry K AU - Melnick, Gerald AU - Taxman, Faye S AU - Young, Douglas W AD - National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Bethesda, MD 20892, United States Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - S54 EP - S64 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 103 IS - Supplement 1 SN - 0376-8716, 0376-8716 KW - Interorganizational relationships Systems integration Criminal justice Cross-agency collaboration Substance abuse treatment KW - Offenders KW - Criminal justice KW - Drug abuse KW - Social services KW - Substance abuse KW - Interagency collaboration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Measuring+collaboration+and+integration+activities+in+criminal+justice+and+substance+abuse+treatment+agencies&rft.au=Fletcher%2C+Bennett+W%3BLehman%2C+Wayne+E+K%3BWexler%2C+Harry+K%3BMelnick%2C+Gerald%3BTaxman%2C+Faye+S%3BYoung%2C+Douglas+W&rft.aulast=Fletcher&rft.aufirst=Bennett&rft.date=2009-08-01&rft.volume=103&rft.issue=Supplement+1&rft.spage=S54&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.01.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Substance abuse; Criminal justice; Interagency collaboration; Offenders; Social services; Drug abuse DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.01.001 ER - TY - JOUR T1 - Organizational factors and collaboration and integration activities in criminal justice and drug abuse treatment agencies AN - 57295589; 200922847 AB - Despite strong interest in improving collaborations between correctional and substance abuse treatment organizations, there is a lack of empirical data describing the existing practices. The current study used a national survey of correctional administrators to examine organizational factors related to cross-agency collaboration and integration activities between corrections and substance abuse treatment organizations. Using a measure of collaboration that scaled cross-agency activities from less structured, informal networking and coordination to more structured and formalized levels of cooperation and collaboration, we found that different correctional settings (e.g., community corrections, jails, prisons) differed significantly in terms of their collaborative activities with substance abuse treatment agencies. We also found that the organizational characteristics that were associated with different levels of collaboration and integration differed across the correctional settings. Further research is needed to better understand how and why correctional agencies decide to formalize collaborative arrangements with treatment agencies and whether these efforts lead to more favorable outcomes. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Lehman, Wayne E K AU - Fletcher, Bennett W AU - Wexler, Harry K AU - Melnick, Gerald AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - S65 EP - S72 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 103 IS - Supplement 1 SN - 0376-8716, 0376-8716 KW - Interorganizational relationships Systems integration Criminal justice Drug abuse treatment Organizational characteristics KW - Networking KW - Prisons KW - Organizational factors KW - Cooperation KW - Criminal justice KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57295589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Organizational+factors+and+collaboration+and+integration+activities+in+criminal+justice+and+drug+abuse+treatment+agencies&rft.au=Lehman%2C+Wayne+E+K%3BFletcher%2C+Bennett+W%3BWexler%2C+Harry+K%3BMelnick%2C+Gerald&rft.aulast=Lehman&rft.aufirst=Wayne+E&rft.date=2009-08-01&rft.volume=103&rft.issue=Supplement+1&rft.spage=S65&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.01.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Prisons; Substance abuse; Organizational factors; Criminal justice; Cooperation; Networking DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.01.004 ER - TY - JOUR T1 - Health status and peer relationships in early adolescence: the role of peer contact, self-esteem, and social anxiety AN - 37121296; 3858423 AB - We examined associations between children's health status and the quality of their peer relationships, as well as factors that may account for individual variation in the quality of chronically ill and healthy children's peer relationships. Our sample included 268 children (138 boys; 130 girls) with 149 European-Americans and 119 African-Americans. There were 91 children with a chronic illness; 35 with asthma, 26 with diabetes, and 30 with obesity. Chronically ill children were characterized by teachers as displaying less prosocial behavior, less overt aggression, and less relational aggression with peers than healthy children. Chronically ill children reported lower levels of peer contact and higher levels of social anxiety than healthy children. Among chronically ill children those with high self-esteem were more prosocial and less aggressive than those with low self-esteem. Our findings suggest that chronically ill children are at risk for peer relationship difficulties, but that self-esteem may serve as a protective factor against poor peer relationships for some chronically ill children. Reprinted by permission of Springer JF - Journal of child and family studies AU - McCarroll, M AU - Lindsey, W AU - MacKinnon-Lewis, Carol AU - Chambers, Campbell AU - Frabutt, M AD - University of Reading ; University of South Florida ; National Institute on Drug Abuse ; University of Notre Dame Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 473 EP - 485 VL - 18 IS - 4 SN - 1062-1024, 1062-1024 KW - Sociology KW - Social relations KW - Anxiety KW - Ethnicity KW - Adolescence KW - Peer groups KW - Health inequality KW - Developmental psychology KW - Self-esteem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37121296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+family+studies&rft.atitle=Health+status+and+peer+relationships+in+early+adolescence%3A+the+role+of+peer+contact%2C+self-esteem%2C+and+social+anxiety&rft.au=McCarroll%2C+M%3BLindsey%2C+W%3BMacKinnon-Lewis%2C+Carol%3BChambers%2C+Campbell%3BFrabutt%2C+M&rft.aulast=McCarroll&rft.aufirst=M&rft.date=2009-08-01&rft.volume=18&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+family+studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-008-9251-9 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9347; 590 652 5676 646 6091; 4435; 11907; 3518 10404; 1147 4196; 5783 5772 6489; 11473 11442 6191 DO - http://dx.doi.org/10.1007/s10826-008-9251-9 ER - TY - JOUR T1 - Within-person variability in urinary bisphenol A concentrations: Measurements from specimens after long-term frozen storage AN - 34541946; 200908-30-0113730 (CE); 10067113 (EN) AB - Background: Bisphenol A (BPA) is an estrogenic contaminant of food and water associated with adverse developmental effects in laboratory animals. BPA has recently been linked to morbidity in adult humans, but studies of developmental effects in humans are methodologically more difficult. The ability to measure BPA in urine samples after long-term storage could aid in such studies. Because the half-life of BPA is < 6h, a single measurement would be useful only if the environmental exposure is relatively constant over weeks or months. Our aims were to evaluate the stability of BPA in specimens after 22-24 years of storage and to measure within-person temporal variability in urinary BPA. Methods: We measured total BPA concentration by mass spectrometry in first-morning urine samples from 60 premenopausal women. We selected from each woman's stored daily collections three urine samples approximately 2 and 4 weeks apart. Samples were selected from both the follicular and luteal phases of the menstrual cycle to assess cycle effects. Temporal variability was assessed with mixed model regression and correlations. Results: BPA levels had an inter-quartile range from 1.1 to 3.1ng/mg creatinine, slightly higher than levels in specimens from NHANES collected 3-11 years later. The Spearman correlation was approximately 0.5 for samples 2 weeks apart and 0.3 for samples 4 weeks apart. Menstrual cycle phase did not influence levels. BPA tended to increase during the three-year collection period, but not significantly. Conclusions: The similar distribution to NHANES samples and correlation of BPA levels taken at 2-week intervals provide indirect evidence that BPA is relatively stable during long-term freezer storage. The correlations indicate generally stable exposures over periods of weeks. These findings suggest that developmental effects of BPA exposure could be investigated with measurements from stored urine. JF - Environmental Research AU - Nepomnaschy, P A AU - Baird, D D AU - Weinberg, C R AU - Hoppin, J A AU - Longnecker, M P AU - Wilcox, A J AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA PY - 2009 SP - 734 EP - 737 PB - Academic Press, Inc , 6277 Sea Harbor Dr , Orlando, FL, 32887-4900, USA, [URL:http://www.academicpress.com] VL - 109 IS - 6 SN - 0013-9351, 0013-9351 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Publisher ID: S0013935109000747 KW - Correlation KW - Urine KW - Bisphenol A KW - Mathematical models KW - Human KW - Phases KW - Temporal logic KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/34541946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Within-person+variability+in+urinary+bisphenol+A+concentrations%3A+Measurements+from+specimens+after+long-term+frozen+storage&rft.au=Nepomnaschy%2C+P+A%3BBaird%2C+D+D%3BWeinberg%2C+C+R%3BHoppin%2C+J+A%3BLongnecker%2C+M+P%3BWilcox%2C+A+J&rft.aulast=Nepomnaschy&rft.aufirst=P&rft.date=2009-08-01&rft.volume=109&rft.issue=6&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2009.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-11-14 DO - http://dx.doi.org/10.1016/j.envres.2009.04.004 ER - TY - JOUR T1 - An Excretory Function for the Escherichia coli Outer Membrane Pore TolC: Upregulation of marA and soxS Transcription and Rob Activity Due to Metabolites Accumulated in tolC Mutants AN - 21325930; 11916925 AB - Efflux pumps function to rid bacteria of xenobiotics, including antibiotics, bile salts, and organic solvents. TolC, which forms an outer membrane channel, is an essential component of several efflux pumps in Escherichia coli. We asked whether TolC has a role during growth in the absence of xenobiotics. Because tolC transcription is activated by three paralogous activators, MarA, SoxS, and Rob, we examined the regulation of these activators in tolC mutants. Using transcriptional fusions, we detected significant upregulation of marRAB and soxS transcription and Rob protein activity in tolC mutants. Three mechanisms could be distinguished: (i) activation of marRAB transcription was independent of marRAB, soxR, and rob functions; (ii) activation of soxS transcription required SoxR, a sensor of oxidants; and (iii) Rob protein was activated posttranscriptionally. This mechanism is similar to the mechanisms of upregulation of marRAB, soxS, and Rob by treatment with certain phenolics, superoxides, and bile salts, respectively. The transcription of other marA/soxS/rob regulon promoters, including tolC itself, was also elevated in tolC mutants. We propose that TolC is involved in the efflux of certain cellular metabolites, not only xenobiotics. As these metabolites accumulate during growth, they trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites, thereby restoring homeostasis. JF - Journal of Bacteriology AU - Rosner, Judah L AU - Martin, Robert G AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0560, jlrosner@helix.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 5283 EP - 5292 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 16 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - SoxS protein KW - Channel pores KW - Outer membranes KW - Solvents KW - Transcription KW - Antibiotics KW - Metabolites KW - Homeostasis KW - Xenobiotics KW - Promoters KW - Bile salts KW - Superoxide KW - Escherichia coli KW - phenolic compounds KW - Oxidants KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21325930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=An+Excretory+Function+for+the+Escherichia+coli+Outer+Membrane+Pore+TolC%3A+Upregulation+of+marA+and+soxS+Transcription+and+Rob+Activity+Due+to+Metabolites+Accumulated+in+tolC+Mutants&rft.au=Rosner%2C+Judah+L%3BMartin%2C+Robert+G&rft.aulast=Rosner&rft.aufirst=Judah&rft.date=2009-08-01&rft.volume=191&rft.issue=16&rft.spage=5283&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00507-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 62 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - SoxS protein; Channel pores; Outer membranes; Solvents; Transcription; Metabolites; Antibiotics; Xenobiotics; Homeostasis; Promoters; Bile salts; Superoxide; phenolic compounds; Oxidants; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00507-09 ER - TY - JOUR T1 - A New Minimal Replicon of Bacillus anthracis Plasmid pXO1 AN - 21308924; 11916917 AB - An 8,883-bp mini-pXO1 plasmid containing a replicon from Bacillus anthracis pXO1 (181.6 kb) was identified by making large deletions in the original plasmid using a newly developed Cre-loxP system. Portions of the truncated mini-pXO1 were cloned into an Escherichia coli vector unable to replicate in B. anthracis. A 5.95-kb region encompassing three putative genes was identified as the minimal pXO1 fragment required for replication of the resulting recombinant shuttle plasmid (named pMR) in B. anthracis. Deletion analysis showed that the only genes essential for replication were the pXO1-14 and pXO1-16 genes, which are transcribed in opposite directions and encode predicted proteins of 66.5 and 67.1 kDa, respectively. The ORF14 protein contains a helix-turn-helix motif, while the ORF16 upstream region contains attributes of a theta-replicating plasmid origin of replication (Ori), namely, an exclusively A+T-containing segment, five 9-bp direct repeats, an inverted repeat, and a A-dependent promoter for the putative replication initiator Rep protein (ORF16). Spontaneous mutations generated in the ORF14, ORF16, and Ori regions of pMR during PCR amplification produced a temperature-sensitive plasmid that is unable to replicate in B. anthracis at 37C. The efficacy of transformation of plasmid-free B. anthracis Ames and Sterne strains by the original pMR was 103 CFU/kg, while Bacillus cereus strains 569 and ATCC 10987 were transformed with efficiencies of 104 and 102 CFU/kg, respectively. Around 95% of B. anthracis cells retained pMR after one round of sporulation and germination. JF - Journal of Bacteriology AU - Pomerantsev, Andrei P AU - Camp, Andrew AU - Leppla, Stephen H Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 5134 EP - 5146 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 16 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Transformation KW - Germination KW - Lymphocytes B KW - Replication KW - Sporulation KW - Bacillus cereus KW - Bacillus anthracis KW - Plasmids KW - Inverted repeat KW - Promoters KW - Colony-forming cells KW - Escherichia coli KW - Replication origins KW - Rep protein KW - Polymerase chain reaction KW - Mutation KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21308924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=A+New+Minimal+Replicon+of+Bacillus+anthracis+Plasmid+pXO1&rft.au=Pomerantsev%2C+Andrei+P%3BCamp%2C+Andrew%3BLeppla%2C+Stephen+H&rft.aulast=Pomerantsev&rft.aufirst=Andrei&rft.date=2009-08-01&rft.volume=191&rft.issue=16&rft.spage=5134&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00422-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 24 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Germination; Transformation; Replication; Lymphocytes B; Sporulation; Plasmids; Inverted repeat; Promoters; Colony-forming cells; Rep protein; Replication origins; Polymerase chain reaction; Mutation; Escherichia coli; Bacillus cereus; Bacillus anthracis DO - http://dx.doi.org/10.1128/JB.00422-09 ER - TY - JOUR T1 - Facets of Personality Linked to Underweight and Overweight AN - 21186366; 11273805 AB - Objective: Personality traits underlie maladaptive behaviors, and cognitive and emotional disturbances that contribute to major preventable causes of global disease burden. This study examines detailed personality profiles of underweight, normal, and overweight individuals to provide insights into the causes and treatments of abnormal weight. Methods: More than half of the population from four towns in Sardinia, Italy (n = 5693; age = 14-94 years; mean plus or minus standard deviation = 43 plus or minus 17 years) were assessed on multiple anthropometric measures and 30 facets that comprehensively cover the five major dimensions of personality, using the Revised NEO Personality Inventory. Results: High Neuroticism and low Conscientiousness were associated with being underweight and obese, respectively. High Impulsiveness (specifically eating-behavior items) and low Order were associated with body mass index categories of overweight and obese, and with measures of abdominal adiposity (waist and hip circumference). Those scoring in the top 10% of Impulsiveness were about 4 kg heavier than those in the bottom 10%, an effect independent and larger than the FTO genetic variant. Prospective analyses confirmed that Impulsiveness and Order were significant predictors of general and central measures of adiposity assessed 3 years later. Conclusions: Overweight and obese individuals have difficulty resisting cravings and lack methodical and organized behaviors that might influence diet and weight control. Although individuals' traits have limited impact on the current obesogenic epidemic, personality traits can improve clinical assessment, suggest points of intervention, and help tailor prevention and treatment approaches. JF - Psychosomatic Medicine AU - Terracciano, A AU - Sutin, A R AU - McCrae, R R AU - Deiana, B AU - Ferrucci, L AU - Schlessinger, D AU - Uda, M AU - Costa, PT Jr AD - Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, 251 Bayview Blvd., Baltimore, MD 21224, USA, Terraccianoa@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 682 EP - 689 VL - 71 IS - 6 SN - 0033-3174, 0033-3174 KW - Physical Education Index; CSA Neurosciences Abstracts; Risk Abstracts KW - Emotions KW - Age KW - obesity KW - Personality KW - Underweight KW - personality KW - Italy KW - Evaluation KW - Genetics KW - Body weight KW - body mass KW - intervention KW - Objectives KW - prevention KW - Diets KW - Inventories KW - Obesity KW - Epidemics KW - Weight control KW - Preventive health KW - Neurosis KW - Italy, Sardegna KW - Hips KW - Standard deviation KW - Cognitive ability KW - towns KW - Analysis KW - Adipose tissue KW - Body mass index KW - Hip KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21186366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Facets+of+Personality+Linked+to+Underweight+and+Overweight&rft.au=Terracciano%2C+A%3BSutin%2C+A+R%3BMcCrae%2C+R+R%3BDeiana%2C+B%3BFerrucci%2C+L%3BSchlessinger%2C+D%3BUda%2C+M%3BCosta%2C+PT+Jr&rft.aulast=Terracciano&rft.aufirst=A&rft.date=2009-08-01&rft.volume=71&rft.issue=6&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Evaluation; Genetics; Obesity; Weight control; Preventive health; Analysis; Objectives; Personality; Hips; Diets; Inventories; Emotions; Age; Epidemics; Neurosis; Underweight; Standard deviation; Body weight; Cognitive ability; Adipose tissue; Body mass index; Hip; body mass; intervention; towns; prevention; obesity; personality; Italy, Sardegna; Italy ER - TY - CONF T1 - Electronic confinement effects and optical properties of multilayer slabs of silicon: numerical model studies AN - 21103169; 11270887 AB - The surface properties of Si(111) : H can be modeled by means of a Si slab with increasing number of layers. A slab is modeled here with a finite periodic potential for electrons, parameterized with information about atomic radii and electron binding energies. The model is then solved numerically to obtain electronic energy levels and the shape of layer orbitals. The procedure provides trends in confinement and optical absorption intensities. Results include electronic band gap excitation energies, and intensities of absorption as function of light frequency, [alpha]([omega]), from calculated electric transition dipoles and density of states. Electronic orbitals obtained here and from previous ab initio calculations show patterns of periodicity due to confinement effects. These effects influence the optical properties of the surface when it is excited by visible light as described by means of absorption selection rules. Our results for the absorption coefficient are compared with experimental curves showing the same pattern of stepwise increases with increasing photon energies. JF - Proceedings of SPIE - The International Society for Optical Engineering AU - Obara, Christopher J AU - Kilin, Dmitri S AU - Micha, David A Y1 - 2009/08// PY - 2009 DA - Aug 2009 PB - SPIE, P.O. BOX 10 Bellingham WA 98227-0010 USA VL - 7396 KW - Environment Abstracts; Environmental Engineering Abstracts KW - Article no. 73960O KW - EE 10:General Environmental Engineering KW - ENA 08:International UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21103169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.atitle=Electronic+confinement+effects+and+optical+properties+of+multilayer+slabs+of+silicon%3A+numerical+model+studies&rft.au=Obara%2C+Christopher+J%3BKilin%2C+Dmitri+S%3BMicha%2C+David+A&rft.aulast=Obara&rft.aufirst=Christopher&rft.date=2009-08-01&rft.volume=7396&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.issn=0277786X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - SuppNotes - Session: Electronic Structure and Dynamics at Interfaces N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Splicing in the eukaryotic ancestor: form, function and dysfunction AN - 21077632; 10252342 AB - Comparative genomics has begun to unravel the evolutionary history of transcript splicing in eukaryotes. The last common ancestor of modern eukaryotes is now known to have had at least moderately intron-dense genes and two complex spliceosomes. For other splicing-related phenomena the evolutionary history is less clear. We suggest that frequent mis-splicing is likely to be ancestral to eukaryotes, whereas trans-splicing and operon splicing are likely to be more recent. The origins of regulated splicing, alternative splicing and splicing of untranslated transcript regions are less certain. The data discussed underscore the significant genomic complexity of early eukaryotes, and should help to frame future questions about the origins of eukaryotic genome structure. JF - Trends in Ecology & Evolution AU - Roy, S W AU - Irimia, M AD - National Library of Medicine, National Institutes of Medicine, Bethesda, MD 20892, USA, royscott@ncbi.nlm.nih.gov PY - 2009 SP - 447 EP - 455 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 24 IS - 8 SN - 0169-5347, 0169-5347 KW - Biochemistry Abstracts 2: Nucleic Acids; Ecology Abstracts KW - Data processing KW - Reviews KW - Transcription KW - Spliceosomes KW - genomics KW - Operons KW - Evolution KW - Alternative splicing KW - D 04040:Ecosystem and Ecology Studies KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21077632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Ecology+%26+Evolution&rft.atitle=Splicing+in+the+eukaryotic+ancestor%3A+form%2C+function+and+dysfunction&rft.au=Roy%2C+S+W%3BIrimia%2C+M&rft.aulast=Roy&rft.aufirst=S&rft.date=2009-08-01&rft.volume=24&rft.issue=8&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Trends+in+Ecology+%26+Evolution&rft.issn=01695347&rft_id=info:doi/10.1016%2Fj.tree.2009.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Data processing; Reviews; Transcription; Spliceosomes; genomics; Operons; Evolution; Alternative splicing DO - http://dx.doi.org/10.1016/j.tree.2009.04.005 ER - TY - JOUR T1 - Lung disease mortality in the United States: the National Longitudinal Mortality Study AN - 21027988; 10865672 AB - SETTING: The National Longitudinal Mortality Study (NLMS) offers the advantage of assessing mortality in a representative population of the United States. OBJECTIVE: To evaluate health disparities associated with lung cancer and chronic obstructive pulmonary disease (COPD) mortality in the United States and whether these associations are similar between these outcomes. DESIGN: The NLMS is a prospective study. Data from NLMS cohort years 1985, 1992, 1993, 1995 and 1996 were included, representing nearly 1.5 million person-years. Lung cancer and COPD mortality relative risks (RRs) from Cox regression analysis, including residential characteristics, marital status, education, health insurance and family income, were evaluated. RESULTS: By 1998, 1273 lung cancer deaths and 772 COPD deaths occurred. Lung cancer mortality rates were approximately two times higher than COPD mortality rates among race and ethnic groups. Cox regression analysis revealed that low education (RR = 1.77, significant, P = 0.01) and low family income (RR = 1.50, significant, P = 0.01) are associated with lung cancer and COPD mortality, controlling for age, race/ethnicity, sex and smoking status. CONCLUSIONS: COPD and lung cancer mortality have similar associations with health disparity indicators in the NLMS data, with some differences in the magnitude of the effect. JF - International Journal of Tuberculosis and Lung Disease AU - Lewis AU - Clegg, L X AU - Johnson, N J AD - Denise Riedel Lewis, Surveillance Research Program, National Cancer Institute, 6116 Executive Blvd., Room 504, MSC 8316, Bethesda, MD 20892-8316, USA, lewisde@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1008 EP - 1014 VL - 13 IS - 8 SN - 1027-3719, 1027-3719 KW - Risk Abstracts KW - Mortality KW - Age KW - Mycobacterium KW - marriage KW - Insurance KW - tuberculosis KW - Smoking KW - USA KW - Education KW - income KW - Ethnic groups KW - Lung cancer KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21027988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Lung+disease+mortality+in+the+United+States%3A+the+National+Longitudinal+Mortality+Study&rft.au=Lewis%3BClegg%2C+L+X%3BJohnson%2C+N+J&rft.aulast=Lewis&rft.aufirst=&rft.date=2009-08-01&rft.volume=13&rft.issue=8&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - tuberculosis; Smoking; Mortality; Age; Education; income; marriage; Insurance; Ethnic groups; chronic obstructive pulmonary disease; Lung cancer; Mycobacterium; USA ER - TY - JOUR T1 - Recombinant Immunotoxins for the Treatment of Chemoresistant Hematologic Malignancies AN - 20954905; 11042154 AB - Recombinant immunotoxins are proteins composed of fragments of monoclonal antibodies fused to truncated protein toxins. No agents of this class are approved yet for medical use, although a related molecule, denileukin diftitox, composed of interleukin-2 fused to truncated diphtheria toxin, is approved for relapsed/refractory cutaneous T-cell lymphoma. Recombinant immunotoxins which have been tested in patients with chemotherapy-pretreated hematologic malignancies include LMB-2 (anti-CD25), BL22 (CAT-3888, anti-CD22) and HA22 (CAT-8015, anti-CD22), each containing an Fv fragment fused to truncated Pseudomonas exotoxin. Major responses were observed with LMB-2 in adult T-cell leukemia, chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma, Hodgkin's disease, and hairy cell leukemia (HCL). BL22 resulted in a high complete remission rate in patients with HCL, particularly those without excessive tumor burden. HA22, an improved version of BL22 with higher affinity to CD22, is now undergoing phase I testing in HCL, CLL, non-Hodgkin's lymphoma, and pediatric acute lymphoblastic leukemia. JF - Current Pharmaceutical Design AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 37/5124b, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 2652 EP - 2664 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 15 IS - 23 SN - 1381-6128, 1381-6128 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Hodgkin's disease KW - Interleukin 2 KW - Monoclonal antibodies KW - Pediatrics KW - Remission KW - Pseudomonas KW - Tumors KW - Exotoxins KW - Toxins KW - Fv KW - Diphtheria toxin KW - Immunotoxins KW - Non-Hodgkin's lymphoma KW - CD22 antigen KW - Malignancy KW - double prime T-cell lymphoma KW - Acute lymphatic leukemia KW - Lymphocytes T KW - Chronic lymphatic leukemia KW - Hairy cell leukemia KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20954905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Pharmaceutical+Design&rft.atitle=Recombinant+Immunotoxins+for+the+Treatment+of+Chemoresistant+Hematologic+Malignancies&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-08-01&rft.volume=15&rft.issue=23&rft.spage=2652&rft.isbn=&rft.btitle=&rft.title=Current+Pharmaceutical+Design&rft.issn=13816128&rft_id=info:doi/10.2174%2F138161209788923949 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hodgkin's disease; Interleukin 2; Pediatrics; Monoclonal antibodies; Remission; Tumors; Immunotoxins; Diphtheria toxin; Fv; Toxins; Exotoxins; Non-Hodgkin's lymphoma; Malignancy; CD22 antigen; Acute lymphatic leukemia; double prime T-cell lymphoma; Lymphocytes T; Hairy cell leukemia; Chronic lymphatic leukemia; Pseudomonas DO - http://dx.doi.org/10.2174/138161209788923949 ER - TY - JOUR T1 - Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection AN - 20945179; 10988543 AB - Acute chorioamnionitis is a response to amniotic fluid (AF) infection. However, it remains unclear whether substantial bacterial propagation in the chorioamniotic membranes (CAMs) precedes microbial invasion of the amniotic cavity (MIAC), which is inconsistent with characteristic 'amniotropic neutrophil migration' in acute chorioamnionitis. This study was performed to determine whether CAMs have widespread bacterial infection during MIAC and whether bacteria normally colonize CAMs. AF pellets and CAMs from the following groups were studied: group 1, patients with positive (n=18) or negative (n=22) AF cultures; group 2, patients with or without acute chorioamnionitis in which the amnion and chorion were studied separately (n=60); and group 3, patients at term who underwent a cesarean delivery (n=30). SYTO 9/propidium iodide fluorescent staining and fluorescent in situ hybridization for 16S rRNA were performed. Real-time quantitative PCR for 16S rDNA and PCR for genital mycoplasmas were also conducted. Bacteria were more frequently detected in AF than in CAMs of patients with positive AF culture (100 vs. 33%; P<0.0001). Bacteria were detected more frequently in CAMs as the severity of chorioamnionitis increased (P<0.01). The median 16S rRNA gene copy number in the amnion was significantly greater than in the chorion (group 2; P<0.0001). Bacteria were not detected in CAMs or AF in women at term before labor (group 3). A fraction of patients with chorioamnionitis or MIAC did not have bacteria in CAMs. Collectively, the findings herein indicate that MIAC does not follow widespread infection of CAMs, but precedes it. We propose a model of MIAC: the initial stage is intra-amniotic bacterial invasion through a discrete region of the CAMs, followed by intra-amniotic proliferation, and bacterial invasion of CAMs primarily extends from the amniotic fluid. This study emphasizes the importance of assessing the intra-amniotic compartment for diagnosis and treatment of preterm birth.Laboratory Investigation (2009) 89, 924-936; doi:10.1038/labinvest.2009.49; published online 8 June 2009 JF - Laboratory Investigation AU - Kim, Mi Jeong AU - Romero, Roberto AU - Gervasi, Maria Teresa AU - Kim, Jung-Sun AU - Yoo, Wonsuk AU - Lee, Deug-Chan AU - Mittal, Pooja AU - Erez, Offer AU - Kusanovic, Juan Pedro AU - Hassan, Sonia S AU - Kim, Chong Jai AD - [1] Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, USA [2] Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA [3] Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 924 EP - 936 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 89 IS - 8 SN - 0023-6837, 0023-6837 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Amniotic fluid KW - Cavities KW - propidium iodide KW - Leukocytes (neutrophilic) KW - Infection KW - Models KW - copy number KW - Leukocyte migration KW - Polymerase chain reaction KW - Chorioamnionitis KW - Cesarean section KW - Chorion KW - Amnion KW - rRNA 16S KW - Mycoplasma KW - Propagation KW - Fluorescence in situ hybridization KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20945179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+Investigation&rft.atitle=Widespread+microbial+invasion+of+the+chorioamniotic+membranes+is+a+consequence+and+not+a+cause+of+intra-amniotic+infection&rft.au=Kim%2C+Mi+Jeong%3BRomero%2C+Roberto%3BGervasi%2C+Maria+Teresa%3BKim%2C+Jung-Sun%3BYoo%2C+Wonsuk%3BLee%2C+Deug-Chan%3BMittal%2C+Pooja%3BErez%2C+Offer%3BKusanovic%2C+Juan+Pedro%3BHassan%2C+Sonia+S%3BKim%2C+Chong+Jai&rft.aulast=Kim&rft.aufirst=Mi&rft.date=2009-08-01&rft.volume=89&rft.issue=8&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=Laboratory+Investigation&rft.issn=00236837&rft_id=info:doi/10.1038%2Flabinvest.2009.49 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Cavities; propidium iodide; Leukocytes (neutrophilic); Infection; copy number; Models; Leukocyte migration; Cesarean section; Chorioamnionitis; Polymerase chain reaction; Amnion; Chorion; rRNA 16S; Propagation; Fluorescence in situ hybridization; Mycoplasma DO - http://dx.doi.org/10.1038/labinvest.2009.49 ER - TY - JOUR T1 - Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization AN - 20939777; 10988664 AB - Learned associations between effects of abused drugs and the drug administration environment are important in drug addiction. Histochemical and electrophysiological studies suggest that these associations are encoded in sparsely distributed nucleus accumbens neurons that are selectively activated by drugs and drug-associated cues. Although correlations have been observed between nucleus accumbens neuronal activity and responsivity to drugs and drug cues, no technique exists for selectively manipulating these activated neurons and establishing their causal role in behavioral effects of drugs and drug cues. Here we describe a new approach, which we term the 'Daun02 inactivation method', that selectively inactivates a minority of neurons previously activated by cocaine in an environment repeatedly paired with cocaine to demonstrate a causal role for these activated neurons in context-specific cocaine-induced psychomotor sensitization in rats. This method provides a new tool for studying the causal roles of selectively activated neurons in behavioral effects of drugs and drug cues and in other learned behaviors. JF - Nature Neuroscience AU - Koya, Eisuke AU - Golden, Sam A AU - Harvey, Brandon K AU - Guez-Barber, Danielle H AU - Berkow, Alexander AU - Simmons, Danielle E AU - Bossert, Jennifer M AU - Nair, Sunila G AU - Uejima, Jamie L AU - Marin, Marcelo T AU - Mitchell, Timothy B AU - Farquhar, David AU - Ghosh, Sukhen C AU - Mattson, Brandi J AU - Hope, Bruce T AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1069 EP - 1073 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 12 IS - 8 SN - 1097-6256, 1097-6256 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Nucleus accumbens KW - Electrophysiological recording KW - Nervous system KW - Neurons KW - Drug abuse KW - Cocaine KW - Drug addiction KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20939777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Neuroscience&rft.atitle=Targeted+disruption+of+cocaine-activated+nucleus+accumbens+neurons+prevents+context-specific+sensitization&rft.au=Koya%2C+Eisuke%3BGolden%2C+Sam+A%3BHarvey%2C+Brandon+K%3BGuez-Barber%2C+Danielle+H%3BBerkow%2C+Alexander%3BSimmons%2C+Danielle+E%3BBossert%2C+Jennifer+M%3BNair%2C+Sunila+G%3BUejima%2C+Jamie+L%3BMarin%2C+Marcelo+T%3BMitchell%2C+Timothy+B%3BFarquhar%2C+David%3BGhosh%2C+Sukhen+C%3BMattson%2C+Brandi+J%3BHope%2C+Bruce+T&rft.aulast=Koya&rft.aufirst=Eisuke&rft.date=2009-08-01&rft.volume=12&rft.issue=8&rft.spage=1069&rft.isbn=&rft.btitle=&rft.title=Nature+Neuroscience&rft.issn=10976256&rft_id=info:doi/10.1038%2Fnn.2364 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Electrophysiological recording; Nucleus accumbens; Nervous system; Neurons; Drug addiction; Cocaine; Drug abuse DO - http://dx.doi.org/10.1038/nn.2364 ER - TY - JOUR T1 - Staphylococcus epidermidis - the 'accidental' pathogen AN - 20937175; 10988807 AB - Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle of S. epidermidis seem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles of S. epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis. JF - Nature Reviews: Microbiology AU - Otto, Michael AD - National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 9000 Rockville Pike Building 33 1W10, Bethesda, Maryland 20892, USA. motto[AT]niaid.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 555 EP - 567 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 7 IS - 8 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Nosocomial infection KW - Commensals KW - Microflora KW - Pathogens KW - Staphylococcus epidermidis KW - Benign KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20937175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=Staphylococcus+epidermidis+-+the+%27accidental%27+pathogen&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2009-08-01&rft.volume=7&rft.issue=8&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Virulence; Nosocomial infection; Microflora; Commensals; Pathogens; Benign; Staphylococcus epidermidis DO - http://dx.doi.org/10.1038/nrmicro2182 ER - TY - JOUR T1 - Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance AN - 20831882; 10994083 AB - We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn-Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the Bgn KO and the most severe in the DKO. This condition progressed with age in all three mouse strains and resulted in the development of large supernumerary sesmoid bones. To determine the role of exercise in the extent of EO, we subjected normal and DKO mice to a treadmill exercise 3 days a week for 4 weeks. In contrast to previous findings using more rigorous exercise regimes, the EO in moderately exercised DKO was decreased compared with unexercised DKO mice. Finally, DKO and Bgn KO mice tested using a rotarod showed a reduced ability to maintain their grip on a rotating cylinder compared with wild-type controls. In summary, we show (1) a detailed description of EO formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function. JF - Scandinavian Journal of Medicine & Science in Sports AU - Kilts, T AU - Ameye, L AU - Syed-Picard, F AU - Ono, M AU - Berendsen, AD AU - Oldberg, A AU - Heegaard, A-M AU - Bi, Y AU - Young, M F AD - 1Molecular Biology of Bones and Teeth Section, Craniofacial and Skeletal Diseases Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Maryland, USA, Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 536 EP - 546 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 19 IS - 4 SN - 0905-7188, 0905-7188 KW - Calcium & Calcified Tissue Abstracts; Physical Education Index KW - Hands KW - Ligaments KW - Bones KW - Animal subjects KW - Aging KW - Sport science KW - Exercise KW - Strains KW - Physical training KW - Bone KW - Proteoglycans KW - Ossification (ectopic) KW - quadriceps muscle KW - Performance KW - Supernumerary KW - Tendons KW - PE 090:Sports Medicine & Exercise Sport Science KW - T 2040:Ectopic Calcification and Ossification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20831882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.atitle=Potential+roles+for+the+small+leucine-rich+proteoglycans+biglycan+and+fibromodulin+in+ectopic+ossification+of+tendon+induced+by+exercise+and+in+modulating+rotarod+performance&rft.au=Kilts%2C+T%3BAmeye%2C+L%3BSyed-Picard%2C+F%3BOno%2C+M%3BBerendsen%2C+AD%3BOldberg%2C+A%3BHeegaard%2C+A-M%3BBi%2C+Y%3BYoung%2C+M+F&rft.aulast=Kilts&rft.aufirst=T&rft.date=2009-08-01&rft.volume=19&rft.issue=4&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.issn=09057188&rft_id=info:doi/10.1111%2Fj.1600-0838.2009.00909.x LA - English DB - Physical Education Index N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Exercise; Animal subjects; Tendons; Ligaments; Bones; Performance; Sport science; Hands; Strains; Physical training; Ossification (ectopic); Proteoglycans; Bone; quadriceps muscle; Supernumerary; Aging DO - http://dx.doi.org/10.1111/j.1600-0838.2009.00909.x ER - TY - JOUR T1 - Producing Recombinant Adeno-Associated Virus in Foster Cells: Overcoming Production Limitations Using a Baculovirus-Insect Cell Expression Strategy AN - 20804730; 10919170 AB - Establishing pharmacological parameters, such as efficacy, routes of administration, and toxicity, for recombinant adeno-associated virus (rAAV) vectors is a prerequisite for gaining acceptance for clinical applications. In fact, even a therapeutic window, that is, the dose range between therapeutic efficacy and toxicity, has yet to be determined for rAAV in vivo. Multiphase clinical trials investigating the safety and efficacy of recombinant AAV-based therapeutics will require unprecedented vector production capacity to meet the needs of preclinical toxicology studies, and the progressive clinical protocol phases of safety/dose escalation (phase I), efficacy (phase II), and high-enrollment, multicenter evaluations (phase III). Methods of rAAV production capable of supporting such trials must be scalable, robust, and efficient. We have taken advantage of the ease of scalability of nonadherent cell culture techniques coupled with the inherent efficiency of viral infection to develop an rAAV production method based on recombinant baculovirus-mediated expression of AAV components in insect-derived suspension cells. JF - Human Gene Therapy AU - Virag, T AU - Cecchini, S AU - Kotin, R M AD - Molecular Virology and Gene Delivery Section, Laboratory of Biochemical Genetics, National Heart, Lung, and Blood institute, National Institutes of Health, Bethesda, MD 20892, USA, kotinr@nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 807 EP - 817 VL - 20 IS - 8 SN - 1043-0342, 1043-0342 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Entomology Abstracts; Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Therapeutic applications KW - Cell culture KW - Toxicity KW - Infection KW - Clinical trials KW - Adeno-associated virus KW - W 30905:Medical Applications KW - Z 05300:General KW - G 07880:Human Genetics KW - V 22410:Animal Diseases KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20804730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Producing+Recombinant+Adeno-Associated+Virus+in+Foster+Cells%3A+Overcoming+Production+Limitations+Using+a+Baculovirus-Insect+Cell+Expression+Strategy&rft.au=Virag%2C+T%3BCecchini%2C+S%3BKotin%2C+R+M&rft.aulast=Virag&rft.aufirst=T&rft.date=2009-08-01&rft.volume=20&rft.issue=8&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2009.092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Gene therapy; Therapeutic applications; Cell culture; Toxicity; Infection; Clinical trials; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2009.092 ER - TY - JOUR T1 - Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity AN - 20802779; 10915190 AB - Genetically engineered lymphocytes hold promise for the treatment of genetic disease, viral infections and cancer. However, current methods for genetic transduction of peripheral blood lymphocytes rely on viral vectors, which are hindered by production and safety-related problems. In this study, we demonstrated an efficient novel nonviral platform for gene transfer to lymphocytes. The Sleeping Beauty transposon-mediated approach allowed for long-term stable expression of transgenes at similar to 50% efficiency. Utilizing transposon constructs expressing tumor antigen-specific T-cell receptor genes targeting p53 and MART-1, we demonstrated sustained expression and functional reactivity of transposon-engineered lymphocytes on encountering target antigen presented on tumor cells. We found that transposon- and retroviral-modified lymphocytes had comparable transgene expression and phenotypic function. These results demonstrate the promise of nonviral ex vivo genetic modification of autologous lymphocytes for the treatment of cancer and immunologic disease.Gene Therapy (2009) 16, 1042-1049; doi:10.1038/gt.2009.54; published online 4 June 2009 JF - Gene Therapy AU - Peng, P D AU - Cohen, C J AU - Yang, S AU - Hsu, C AU - Jones, S AU - Zhao, Y AU - Zheng, Z AU - Rosenberg, S A AU - Morgan, R A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1042 EP - 1049 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 8 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - double prime T-cell receptor KW - Transgenes KW - Peripheral blood KW - Tumors KW - Lymphocytes KW - Infection KW - Tumor cells KW - Cancer KW - p53 protein KW - Transposons KW - MART-1 antigen KW - Genetic engineering KW - Antigen (tumor-associated) KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - V 22350:Immunology KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20802779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Efficient+nonviral+Sleeping+Beauty+transposon-based+TCR+gene+transfer+to+peripheral+blood+lymphocytes+confers+antigen-specific+antitumor+reactivity&rft.au=Peng%2C+P+D%3BCohen%2C+C+J%3BYang%2C+S%3BHsu%2C+C%3BJones%2C+S%3BZhao%2C+Y%3BZheng%2C+Z%3BRosenberg%2C+S+A%3BMorgan%2C+R+A&rft.aulast=Peng&rft.aufirst=P&rft.date=2009-08-01&rft.volume=16&rft.issue=8&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2009.54 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene therapy; double prime T-cell receptor; Transgenes; Peripheral blood; Lymphocytes; Tumors; Infection; Tumor cells; Cancer; p53 protein; Transposons; MART-1 antigen; Genetic engineering; Antigen (tumor-associated) DO - http://dx.doi.org/10.1038/gt.2009.54 ER - TY - JOUR T1 - Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP super(res) detection using seeded conversion of recombinant prion protein AN - 20790168; 10843582 AB - The pathological isoform of the prion protein (PrP super(res)) can serve as a marker for prion diseases, but more practical tests are needed for preclinical diagnosis and sensitive detection of many prion infections. Previously we showed that the quaking-induced conversion (QuIC) assay can detect sub-femtogram levels of PrP super(res) in scrapie-infected hamster brain tissue and distinguish cerebral spinal fluid (CSF) samples from normal and scrapie-infected hamsters. We now report the adaptation of the QuIC reaction to prion diseases of medical and agricultural interest: human variant Creutzfeldt-Jakob disease (vCJD) and sheep scrapie. PrP super(res)-positive and -negative brain homogenates from humans and sheep were discriminated within 1-2 days with a sensitivity of 10-100 fg PrP super(res). More importantly, in as little as 22 h we were able to distinguish CSF samples from scrapie-infected and uninfected sheep. These results suggest the presence of prions in CSF from scrapie-infected sheep. This new method enables the relatively rapid and sensitive detection of human CJD and sheep scrapie PrP super(res) and may facilitate the development of practical preclinical diagnostic and high-throughput interference tests. JF - Protein Engineering Design and Selection AU - Orru, Christina D AU - Wilham, Jason M AU - Hughson, Andrew G AU - Raymond, Lynne D AU - McNally, Kristin L AU - Bossers, Alex AU - Ligios, Ciriaco AU - Caughey, Byron AD - 1 Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases , National Institutes of Health, Rocky Mountain Laboratories , 903 S. 4th St., Hamilton, MT 59840 , USA, bcaughey@nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 515 EP - 521 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 22 IS - 8 SN - 1741-0126, 1741-0126 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - cerebral spinal fluid KW - CJD KW - diagnostics KW - prion KW - scrapie KW - Cerebrospinal fluid KW - Adaptations KW - Creutzfeldt-Jakob disease KW - Prion protein KW - Brain KW - Scrapie KW - Infection KW - W 30925:Genetic Engineering KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20790168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Engineering+Design+and+Selection&rft.atitle=Human+variant+Creutzfeldt-Jakob+disease+and+sheep+scrapie+PrP+super%28res%29+detection+using+seeded+conversion+of+recombinant+prion+protein&rft.au=Orru%2C+Christina+D%3BWilham%2C+Jason+M%3BHughson%2C+Andrew+G%3BRaymond%2C+Lynne+D%3BMcNally%2C+Kristin+L%3BBossers%2C+Alex%3BLigios%2C+Ciriaco%3BCaughey%2C+Byron&rft.aulast=Orru&rft.aufirst=Christina&rft.date=2009-08-01&rft.volume=22&rft.issue=8&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Protein+Engineering+Design+and+Selection&rft.issn=17410126&rft_id=info:doi/10.1093%2Fprotein%2Fgzp031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cerebrospinal fluid; Adaptations; Creutzfeldt-Jakob disease; Brain; Prion protein; Scrapie; Infection DO - http://dx.doi.org/10.1093/protein/gzp031 ER - TY - JOUR T1 - Do Muscle Mass, Muscle Density, Strength, and Physical Function Similarly Influence Risk of Hospitalization in Older Adults? AN - 20782164; 10841831 AB - OBJECTIVES: To examine the association between strength, function, lean mass, muscle density, and risk of hospitalization.DESIGN: Prospective cohort study.SETTING: Two U.S. clinical centers.PARTICIPANTS: Adults aged 70 to 80 (N=3,011) from the Health, Aging and Body Composition Study.MEASUREMENTS: Measurements were of grip strength, knee extension strength, lean mass, walking speed, and chair stand pace. Thigh computed tomography scans assessed muscle area and density (a proxy for muscle fat infiltration). Hospitalizations were confirmed by local review of medical records. Negative binomial regression models estimated incident rate ratios (IRRs) of hospitalization for race- and sex-specific quartiles of each muscle and function parameter separately. Multivariate models adjusted for age, body mass index, health status, and coexisting medical conditions.RESULTS: During an average 4.7 years of follow-up, 1,678 (55.7%) participants experienced one or more hospitalizations. Participants in the lowest quartile of muscle density were more likely to be subsequently hospitalized (multivariate IRR=1.47, 95% confidence interval (CI)=1.24-1.73) than those in the highest quartile. Similarly, participants with the weakest grip strength were at greater risk of hospitalization (multivariate IRR=1.52, 95% CI=1.30-1.78, Q1 vs. Q4). Comparable results were seen for knee strength, walking pace, and chair stands pace. Lean mass and muscle area were not associated with risk of hospitalization.CONCLUSION: Weak strength, poor function, and low muscle density, but not muscle size or lean mass, were associated with greater risk of hospitalization. Interventions to reduce the disease burden associated with sarcopenia should focus on increasing muscle strength and improving physical function rather than simply increasing lean mass. JF - Journal of the American Geriatrics Society AU - Cawthon, Peggy Mannen AU - Fox, Kathleen M AU - Gandra, Shravanthi R AU - Delmonico, Matthew J AU - Chiou, Chiun-Fang AU - Anthony, Mary S AU - Sewall, Ase AU - Goodpaster, Bret AU - Satterfield, Suzanne AU - Cummings, Steven R AU - Harris, Tamara B AD - Intramural Research Program, National Institute on Aging, Bethesda, Maryland. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1411 EP - 1419 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 57 IS - 8 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - Muscles KW - USA KW - computed tomography KW - body mass KW - intervention KW - Reviews KW - Infiltration KW - aging KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20782164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Do+Muscle+Mass%2C+Muscle+Density%2C+Strength%2C+and+Physical+Function+Similarly+Influence+Risk+of+Hospitalization+in+Older+Adults%3F&rft.au=Cawthon%2C+Peggy+Mannen%3BFox%2C+Kathleen+M%3BGandra%2C+Shravanthi+R%3BDelmonico%2C+Matthew+J%3BChiou%2C+Chiun-Fang%3BAnthony%2C+Mary+S%3BSewall%2C+Ase%3BGoodpaster%2C+Bret%3BSatterfield%2C+Suzanne%3BCummings%2C+Steven+R%3BHarris%2C+Tamara+B&rft.aulast=Cawthon&rft.aufirst=Peggy&rft.date=2009-08-01&rft.volume=57&rft.issue=8&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2009.02366.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Muscles; Reviews; aging; computed tomography; intervention; Infiltration; body mass; Age DO - http://dx.doi.org/10.1111/j.1532-5415.2009.02366.x ER - TY - JOUR T1 - Simultaneous determination of fluoroquinolones, sulfonamides and tetracyclines in sewage sludge by pressurized liquid extraction and liquid chromatography electrospray ionization-mass spectrometry AN - 20768482; 10277614 AB - A new scheme for the quantitative determination of traces of fluoroquinolones (FQs), tetracyclines (TCs) and sulfonamides (SAs) in sewage sludge was developed. The compounds were simultaneously extracted from sewage sludge by pressurized liquid extraction (PLE). A novel and effective method for PLE was developed. Solid-phase extraction was used for cleaning up the extracts. Identification and quantification of the compounds was done using high-performance liquid chromatography with electrospray ionization mass spectrometry in selected reaction monitoring mode. The best recovery of FQs and TCs was obtained by using hydrophilic-lipophilic balance cartridges, recoveries ranged 59% for norfloxacin to 82% for ofloxacin and 95% for doxycycline; for SAs strong cation-exchange cartridges were more efficient, recoveries were 96% for sulfamethoxazole and 43% for sulfadimethoxine. Limit of quantification ranged from 0.1 ng/g for SAs to 160 ng/g for tetracycline. Method precision for TCs was 5.06% and 1.12%, and for SAs 0.43% and 2.01%. FQs precision ranged from 0.77% to 1.89%. JF - Journal of Chromatography A AU - Lillenberg, Merike AU - Yurchenko, Sergei AU - Kipper, Karin AU - Herodes, Koit AU - Pihl, Viljar AU - Sepp, Kalev AU - Lohmus, Ruenno AU - Nei, Lembit AD - Department of Food Science and Hygiene, Estonian University of Life Sciences, Kreutzwaldi 58A, 51014 Tartu, Estonia, lembit.nei@ttu.ee Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 5949 EP - 5954 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 1216 IS - 32 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Toxicology Abstracts; Aqualine Abstracts KW - Sewage sludge KW - Fluoroquinolones KW - Tetracyclines KW - Sulfonamides KW - PLE KW - SPE KW - HPLC-ESI-MS KW - High-performance liquid chromatography KW - Molecular structure KW - Mass Spectrometry KW - Sulfadimethoxine KW - Norfloxacin KW - Chromatographic techniques KW - Ofloxacin KW - Liquid Sludge KW - Mass spectroscopy KW - Liquid Chromatography KW - Sulfamethoxazole KW - Sludge KW - Cleaning KW - Spectrometry KW - Sewage KW - Liquid chromatography KW - Precision KW - Monitoring KW - Ionization KW - Wastewater KW - Doxycycline KW - SW 3040:Wastewater treatment processes KW - AQ 00006:Sewage KW - Q5 08502:Methods and instruments KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20768482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Simultaneous+determination+of+fluoroquinolones%2C+sulfonamides+and+tetracyclines+in+sewage+sludge+by+pressurized+liquid+extraction+and+liquid+chromatography+electrospray+ionization-mass+spectrometry&rft.au=Lillenberg%2C+Merike%3BYurchenko%2C+Sergei%3BKipper%2C+Karin%3BHerodes%2C+Koit%3BPihl%2C+Viljar%3BSepp%2C+Kalev%3BLohmus%2C+Ruenno%3BNei%2C+Lembit&rft.aulast=Lillenberg&rft.aufirst=Merike&rft.date=2009-08-01&rft.volume=1216&rft.issue=32&rft.spage=5949&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2009.06.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Molecular structure; Sewage; Chromatographic techniques; Sludge; High-performance liquid chromatography; Sulfadimethoxine; Norfloxacin; Fluoroquinolones; Sulfamethoxazole; Sewage sludge; Ofloxacin; Tetracyclines; Mass spectroscopy; Spectrometry; Liquid chromatography; Sulfonamides; Doxycycline; Mass Spectrometry; Precision; Liquid Chromatography; Liquid Sludge; Monitoring; Ionization; Wastewater; Cleaning DO - http://dx.doi.org/10.1016/j.chroma.2009.06.029 ER - TY - JOUR T1 - Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling AN - 20748304; 9430570 AB - The role of genetics in driving intracortical relationships is an important question that has rarely been studied in humans. In particular, there are no extant high-resolution imaging studies on genetic covariance. In this article, we describe a novel method that combines classical quantitative genetic methodologies for variance decomposition with recently developed semi-multivariate algorithms for high- resolution measurement of phenotypic covariance. Using these tools, we produced correlational maps of genetic and environmental (i.e. nongenetic) relationships between several regions of interest and the cortical surface in a large pediatric sample of 600 twins, siblings, and singletons. These analyses demonstrated high, fairly uniform, statistically significant genetic correlations between the entire cortex and global mean cortical thickness. In agreement with prior reports on phenotypic covariance using similar methods, we found that mean cortical thickness was most strongly correlated with association cortices. However, the present study suggests that genetics plays a large role in global brain patterning of cortical thickness in this manner. Further, using specific gyri with known high heritabilities as seed regions, we found a consistent pattern of high bilateral genetic correlations between structural homologues, with environmental correlations more restricted to the same hemisphere as the seed region, suggesting that interhemispheric covariance is largely genetically mediated. These findings are consistent with the limited existing knowledge on the genetics of cortical variability as well as our prior multivariate studies on cortical gyri. JF - NeuroImage AU - Schmitt, JEric AU - Lenroot, Rhoshel K AU - Ordaz, Sarah E AU - Wallace, Gregory L AU - Lerch, Jason P AU - Evans, Alan C AU - Prom, Elizabeth C AU - Kendler, Kenneth S AU - Neale, Michael C AU - Giedd, Jay N AD - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA, jg@nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 56 EP - 64 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 47 IS - 1 SN - 1053-8119, 1053-8119 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Seeds KW - Neuroimaging KW - Mathematical models KW - Pediatrics KW - Cerebral hemispheres KW - Statistical analysis KW - Algorithms KW - Brain KW - Decomposition KW - Cortex KW - Twins KW - Siblings KW - Heritability KW - Gene mapping KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20748304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Variance+decomposition+of+MRI-based+covariance+maps+using+genetically+informative+samples+and+structural+equation+modeling&rft.au=Schmitt%2C+JEric%3BLenroot%2C+Rhoshel+K%3BOrdaz%2C+Sarah+E%3BWallace%2C+Gregory+L%3BLerch%2C+Jason+P%3BEvans%2C+Alan+C%3BProm%2C+Elizabeth+C%3BKendler%2C+Kenneth+S%3BNeale%2C+Michael+C%3BGiedd%2C+Jay+N&rft.aulast=Schmitt&rft.aufirst=JEric&rft.date=2009-08-01&rft.volume=47&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.06.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Seeds; Mathematical models; Pediatrics; Cerebral hemispheres; Brain; Algorithms; Statistical analysis; Decomposition; Twins; Cortex; Siblings; Heritability; Gene mapping DO - http://dx.doi.org/10.1016/j.neuroimage.2008.06.039 ER - TY - JOUR T1 - Orally administered H-Dmt-Tic-Lys-NH-CH sub(2)-Ph (MZ-2), a potent k-/d-opioid receptor antagonist, regulates obese-related factors in mice AN - 20701809; 10828612 AB - Orally active dual k-/d-opioid receptor antagonist, H-Dmt-Tic-Lys-NH-CH sub(2)-Ph (MZ-2) was applied to study body weight gain, fat content, bone mineral density, serum insulin, cholesterol and glucose levels in female ob/ob (B6.V-Lep/J homozygous) and lean wild mice with or without voluntary exercise on wheels for three weeks, and during a two week post-treatment period under the same conditions. MZ-2 (10 mg/kg/day, p.o.) exhibited the following actions: (1) reduced body weight gain in sedentary obese mice that persisted beyond the treatment period without effect on lean mice; (2) stimulated voluntary running on exercise wheels of both groups of mice; (3) decreased fat content, enhanced bone mineral density (BMD), and decreased serum insulin and glucose levels in obese mice; and (4) MZ-2 (30 kM) increased BMD in human osteoblast cells (MG- 63) comparable to naltrexone, while morphine inhibited mineral nodule formation. Thus, MZ-2 has potential application in the clinical management of obesity, insulin and glucose levels, and the amelioration of osteoporosis. JF - European Journal of Pharmacology AU - Marczak, Ewa D AU - Jinsmaa, Yunden AU - Myers, Page H AU - Blankenship, Terry AU - Wilson, Ralph AU - Balboni, Gianfranco AU - Salvadori, Severo AU - Lazarus, Lawrence H AD - Medicinal Chemistry Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, marczake@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 115 EP - 121 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 616 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Toxicology Abstracts KW - Body weight gain KW - Bone mineral density KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20701809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Orally+administered+H-Dmt-Tic-Lys-NH-CH+sub%282%29-Ph+%28MZ-2%29%2C+a+potent+k-%2Fd-opioid+receptor+antagonist%2C+regulates+obese-related+factors+in+mice&rft.au=Marczak%2C+Ewa+D%3BJinsmaa%2C+Yunden%3BMyers%2C+Page+H%3BBlankenship%2C+Terry%3BWilson%2C+Ralph%3BBalboni%2C+Gianfranco%3BSalvadori%2C+Severo%3BLazarus%2C+Lawrence+H&rft.aulast=Marczak&rft.aufirst=Ewa&rft.date=2009-08-01&rft.volume=616&rft.issue=1-3&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/10.1016%2Fj.ejphar.2009.06.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Bone mineral density DO - http://dx.doi.org/10.1016/j.ejphar.2009.06.041 ER - TY - JOUR T1 - Role of oxidative stress in cadmium toxicity and carcinogenesis AN - 20684119; 10135447 AB - Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity, osteotoxicity and tumors after prolonged exposures. Reactive oxygen species (ROS) are often implicated in Cd toxicology. This minireview focused on direct evidence for the generation of free radicals in intact animals following acute Cd overload and discussed the association of ROS in chronic Cd toxicity and carcinogenesis. Cd-generated superoxide anion, hydrogen peroxide, and hydroxyl radicals in vivo have been detected by the electron spin resonance spectra, which are often accompanied by activation of redox sensitive transcription factors (e.g., NF-B, AP-1 and Nrf2) and alteration of ROS-related gene expression. It is generally agreed upon that oxidative stress plays important roles in acute Cd poisoning. However, following long-term Cd exposure at environmentally-relevant low levels, direct evidence for oxidative stress is often obscure. Alterations in ROS-related gene expression during chronic exposures are also less significant compared to acute Cd poisoning. This is probably due to induced adaptation mechanisms (e.g., metallothionein and glutathione) following chronic Cd exposures, which in turn diminish Cd-induced oxidative stress. In chronic Cd-transformed cells, less ROS signals are detected with fluorescence probes. Acquired apoptotic tolerance renders damaged cells to proliferate with inherent oxidative DNA lesions, potentially leading to tumorigenesis. Thus, ROS are generated following acute Cd overload and play important roles in tissue damage. Adaptation to chronic Cd exposure reduces ROS production, but acquired Cd tolerance with aberrant gene expression plays important roles in chronic Cd toxicity and carcinogenesis. JF - Toxicology and Applied Pharmacology AU - Liu, J AU - Qu, W AU - Kadiiska, M B AD - Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 T.W. Alexander Drive, MD F0-09, Research Triangle Park, NC 27709, USA, Liu6@niehs.nih.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 209 EP - 214 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 238 IS - 3 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Testes KW - Anions KW - Apoptosis KW - Metallothionein KW - Heavy metals KW - Glutathione KW - adaptability KW - Gene expression KW - Reactive oxygen species KW - Oxidative stress KW - Chronic exposure KW - Hydrogen peroxide KW - Chronic toxicity KW - Acute intoxication KW - Fluorescent indicators KW - Cadmium KW - immunotoxicity KW - Adaptations KW - Fluorescence KW - Free radicals KW - Tumorigenesis KW - Activator protein 1 KW - Poisoning KW - Toxicity KW - oxidative stress KW - Hydroxyl radicals KW - Immunotoxicity KW - Lung KW - Reviews KW - Transcription factors KW - Carcinogenesis KW - NF-B protein KW - Kidney KW - Liver KW - DNA KW - superoxide anions KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20684119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Role+of+oxidative+stress+in+cadmium+toxicity+and+carcinogenesis&rft.au=Liu%2C+J%3BQu%2C+W%3BKadiiska%2C+M+B&rft.aulast=Liu&rft.aufirst=J&rft.date=2009-08-01&rft.volume=238&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.01.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Testes; Apoptosis; Metallothionein; Glutathione; Heavy metals; Gene expression; Reactive oxygen species; Hydrogen peroxide; Chronic exposure; Oxidative stress; Acute intoxication; Fluorescent indicators; Cadmium; Fluorescence; Adaptations; Free radicals; Activator protein 1; Tumorigenesis; Poisoning; Immunotoxicity; Lung; Transcription factors; Reviews; NF-B protein; Carcinogenesis; DNA; Liver; Kidney; superoxide anions; Anions; Chronic toxicity; Toxicity; immunotoxicity; oxidative stress; Hydroxyl radicals; adaptability DO - http://dx.doi.org/10.1016/j.taap.2009.01.029 ER - TY - JOUR T1 - Preparation and characterization of solid biomass fuel made from rice straw and rice bran AN - 20683292; 9454824 AB - This study investigated the preparation and characterization of the solid fuel briquette, which was made from rice straw and rice bran. This work included: (1) developing a machine to smash the rice straw into pieces; (2) compressing the smashed rice straws and the rice bran into the biomass briquette; and (3) characterizing the properties of the briquette (such as the percentage of change in briquette volume, the percentage of loss of briquette mass, the air-dry density, the compressive strength, and the heating value) at room temperature. The hot-pressing temperature strongly affects the compressive strength of the briquette. As the percentage of the rice bran increases, the compressive strength and the heating value of the biomass briquette increase. Most interestingly, the thermo-energy, which is used to compress the briquette of the rice straw, will be minimized if a certain percentage of the binder (such as rice bran, sawdust, or the other biomass waste) is mixed with the smashed rice straw. JF - Fuel Processing Technology AU - Chou, Chuen-Shii AU - Lin, Sheau-Horng AU - Lu, Wen-Chung AD - Powder Technology R&D Laboratory, Department of Mechanical Engineering, National Pingtung University of Science and Technology, Pingtung 1, Hseuh Fu Road, Nei-Pu Hsiang, Pingtung 91201, Taiwan, Republic of China, cschou@mail.npust.edu.tw Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 980 EP - 987 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 7-8 SN - 0378-3820, 0378-3820 KW - Environment Abstracts KW - Rice straw KW - Rice bran KW - Solid biomass fuel KW - Compressive strength KW - Heating value KW - Fuels KW - Temperature KW - Oryza sativa KW - Biomass KW - ENA 03:Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20683292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fuel+Processing+Technology&rft.atitle=Preparation+and+characterization+of+solid+biomass+fuel+made+from+rice+straw+and+rice+bran&rft.au=Chou%2C+Chuen-Shii%3BLin%2C+Sheau-Horng%3BLu%2C+Wen-Chung&rft.aulast=Chou&rft.aufirst=Chuen-Shii&rft.date=2009-08-01&rft.volume=90&rft.issue=7-8&rft.spage=980&rft.isbn=&rft.btitle=&rft.title=Fuel+Processing+Technology&rft.issn=03783820&rft_id=info:doi/10.1016%2Fj.fuproc.2009.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fuels; Temperature; Biomass; Oryza sativa DO - http://dx.doi.org/10.1016/j.fuproc.2009.04.012 ER - TY - JOUR T1 - The optimum conditions for preparing solid fuel briquette of rice straw by a piston-mold process using the Taguchi method AN - 20682643; 9454803 AB - Using the Taguchi method, this study analyzed the optimum conditions for preparing the solid fuel briquette of the rice straw by a piston-mold process. The controllable factors used in this study consisted of the following: (1) the type of binder (such as the rice bran, the soybean residue, and the sawdust of Acacia confuse), (2) the hot-pressing temperature (such as 110, 130, and 150 C), (3) the size of the smashed rice straw (such as 10-5 mm, 5-2 mm, and < 2 mm), and (4) the percentage ratio of rice straw to binder in a briquette (such as 100/0, 80/20, and 60/40). The percentage contribution of each controllable factor was also determined. The confirmation experiment was carried out according to the optimum conditions. Most interestingly, the size of the smashed rice straw is the most influential factor to solidify fuel briquette, and its value is up to 43.0%. JF - Fuel Processing Technology AU - Chou, Chuen-Shii AU - Lin, Sheau-Horng AU - Peng, Chun-Chieh AU - Lu, Wen-Chung AD - Powder Technology R&D Laboratory, Department of Mechanical Engineering, National Pingtung University of Science and Technology, Pingtung.1, Hseuh Fu Road, Nei-Pu Hsiang, Pingtung 91201, Taiwan, cschou@mail.npust.edu.tw Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1041 EP - 1046 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 7-8 SN - 0378-3820, 0378-3820 KW - Environment Abstracts KW - Rice straw KW - Solid fuel briquette KW - Taguchi method KW - Piston-mold process KW - Residues KW - Fuels KW - Temperature KW - Oryza sativa KW - Acacia KW - soybeans KW - ENA 03:Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20682643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fuel+Processing+Technology&rft.atitle=The+optimum+conditions+for+preparing+solid+fuel+briquette+of+rice+straw+by+a+piston-mold+process+using+the+Taguchi+method&rft.au=Chou%2C+Chuen-Shii%3BLin%2C+Sheau-Horng%3BPeng%2C+Chun-Chieh%3BLu%2C+Wen-Chung&rft.aulast=Chou&rft.aufirst=Chuen-Shii&rft.date=2009-08-01&rft.volume=90&rft.issue=7-8&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Fuel+Processing+Technology&rft.issn=03783820&rft_id=info:doi/10.1016%2Fj.fuproc.2009.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Residues; Fuels; Temperature; soybeans; Oryza sativa; Acacia DO - http://dx.doi.org/10.1016/j.fuproc.2009.04.007 ER - TY - JOUR T1 - Strategies for longitudinal neuroimaging studies of overt language production AN - 20680095; 10140771 AB - Longitudinal fMRI studies of language production are of interest for evaluating recovery from post- stroke aphasia, but numerous methodological issues remain unresolved, particularly regarding strategies for evaluating single subjects at multiple timepoints. To address these issues, we studied overt picture naming in eleven healthy subjects, scanned four times each at one-month intervals. To evaluate the natural variability present across repeated sessions, repeated scans were directly contrasted in a unified statistical framework on a per-voxel basis. The effect of stimulus familiarity was evaluated using explicitly overtrained pictures, novel pictures, and untrained pictures that were repeated across sessions. For untrained pictures, we found that activation declined across multiple sessions, equally for both novel and repeated stimuli. Thus, no repetition priming for individual stimuli at one-month intervals was found, but rather a general effect of task habituation was present. Using a set of overtrained pictures identical in each session, no decline was found, but activation was minimized and produced less consistent patterns across participants, as measured by intra-class correlation coefficients. Subtraction of a baseline task, in which subjects produced a stereotyped utterance to scrambled pictures, resulted in specific activations in the left inferior frontal gyrus and other language areas for untrained items, while overlearned stimuli relative to pseudo pictures activated only the fusiform gyrus and supplementary motor area. These findings indicate that longitudinal fMRI is an effective means of detecting changes in neural activation magnitude over time, as long as the effect of task habituation is taken into account. JF - NeuroImage AU - Meltzer, Jed A AU - Postman-Caucheteux, Whitney A AU - McArdle, Joseph J AU - Braun, Allen R AD - Language Section, Voice, Speech, and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10 Center Drive, Building 10, Rm 5C410, Bethesda, MD 20892-1065, USA, jed.meltzer@aya.yale.edu Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 745 EP - 755 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 47 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Repetition KW - frontal gyrus KW - Neuroimaging KW - supplementary motor area KW - Statistics KW - Functional magnetic resonance imaging KW - Stroke KW - Language KW - Familiarity KW - aphasia KW - Habituation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20680095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Strategies+for+longitudinal+neuroimaging+studies+of+overt+language+production&rft.au=Meltzer%2C+Jed+A%3BPostman-Caucheteux%2C+Whitney+A%3BMcArdle%2C+Joseph+J%3BBraun%2C+Allen+R&rft.aulast=Meltzer&rft.aufirst=Jed&rft.date=2009-08-01&rft.volume=47&rft.issue=2&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.04.089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - frontal gyrus; Repetition; supplementary motor area; Neuroimaging; Statistics; Functional magnetic resonance imaging; Stroke; Language; aphasia; Familiarity; Habituation DO - http://dx.doi.org/10.1016/j.neuroimage.2009.04.089 ER - TY - JOUR T1 - Ornithodoros savignyi: Soft tick apyrase belongs to the 5'-nucleotidase family AN - 20677823; 9451868 AB - Salivary apyrases are nucleotide-metabolising enzymes that blood-feeding parasites utilise for modulation of extracellular nucleotides to prevent platelet activation and aggregation. In this study a 5'-nucleotidase specific degenerate primer was used to identify homologous transcripts from Ornithodoros savignyi salivary gland cDNA. Two 5'-nucleotidase isoforms that share significant sequence identity to putative apyrases from Rhipicephalus appendiculatus and Ixodes scapularis were identified. Structure prediction showed a tertiary structure similar to periplasmic ecto-5'-nucleotidase from Escherichia coli, with high conservation of functional residues. The O. savignyi 5'-nucleotidase isoform I was recombinantly expressed in Pichia pastoris. Cross-reactivity was demonstrated with polyclonal anti-apyrase antisera produced against O. savignyi apyrase. Subsequent Edman sequencing and MS/MS analysis of purified O. savignyi apyrase identified peptide sequence fragments that shared sequence identity with both newly identified 5'-nucleotidase isoforms. It was concluded that wild-type apyrase is a mixture of the isoforms identified from the salivary glands of O. savignyi. These results represent the first confirmation of a soft (argasid) tick apyrase that belongs to the 5'-nucleotidase family of enzymes. JF - Experimental Parasitology AU - Stutzer, C AU - Mans, B J AU - Gaspar, ARM AU - Neitz, AWH AU - Maritz-Olivier, C AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA, mansb@arc.agric.za Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 318 EP - 327 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 122 IS - 4 SN - 0014-4894, 0014-4894 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - 5'-Nucleotidase KW - Cross-reactivity KW - Ixodidae KW - Enzymes KW - Ixodes scapularis KW - Salivary gland KW - Apyrase KW - Nucleotides KW - Protein structure KW - Antisera KW - Escherichia coli KW - Platelets KW - Conservation KW - Primers KW - Pichia pastoris KW - Tertiary structure KW - Ornithodoros savignyi KW - Rhipicephalus appendiculatus KW - J 02410:Animal Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Parasitology&rft.atitle=Ornithodoros+savignyi%3A+Soft+tick+apyrase+belongs+to+the+5%27-nucleotidase+family&rft.au=Stutzer%2C+C%3BMans%2C+B+J%3BGaspar%2C+ARM%3BNeitz%2C+AWH%3BMaritz-Olivier%2C+C&rft.aulast=Stutzer&rft.aufirst=C&rft.date=2009-08-01&rft.volume=122&rft.issue=4&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Experimental+Parasitology&rft.issn=00144894&rft_id=info:doi/10.1016%2Fj.exppara.2009.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein structure; 5'-Nucleotidase; Antisera; Cross-reactivity; Platelets; Conservation; Enzymes; Primers; Tertiary structure; Salivary gland; Nucleotides; Apyrase; Ixodidae; Escherichia coli; Ixodes scapularis; Pichia pastoris; Ornithodoros savignyi; Rhipicephalus appendiculatus DO - http://dx.doi.org/10.1016/j.exppara.2009.04.007 ER - TY - JOUR T1 - Common neural substrates support speech and non-speech vocal tract gestures AN - 20674292; 9430555 AB - The issue of whether speech is supported by the same neural substrates as non-speech vocal tract gestures has been contentious. In this fMRI study we tested whether producing non-speech vocal tract gestures in humans shares the same functional neuroanatomy as non-sense speech syllables. Production of non- speech vocal tract gestures, devoid of phonological content but similar to speech in that they had familiar acoustic and somatosensory targets, was compared to the production of speech syllables without meaning. Brain activation related to overt production was captured with BOLD fMRI using a sparse sampling design for both conditions. Speech and non-speech were compared using voxel-wise whole brain analyses, and ROI analyses focused on frontal and temporoparietal structures previously reported to support speech production. Results showed substantial activation overlap between speech and non-speech function in regions. Although non-speech gesture production showed greater extent and amplitude of activation in the regions examined, both speech and non-speech showed comparable left laterality in activation for both target perception and production. These findings posit a more general role of the previously proposed "auditory dorsal stream" in the left hemisphere - to support the production of vocal tract gestures that are not limited to speech processing. JF - NeuroImage AU - Chang, Soo-Eun AU - Kenney, Mary Kay AU - Loucks, Torrey MJ AU - Poletto, Christopher J AU - Ludlow, Christy L AD - Laryngeal and Speech Section, Medical Neurology Branch, NINDS/NIH, 10 Center Dr. MSC 1416 Building 10, Room 5D38, Bethesda, MD 20892, USA, ludlowc@ninds.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 314 EP - 325 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 47 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Sensory-motor interaction KW - Auditory dorsal stream KW - Functional magnetic resonance imaging (fMRI) KW - Speech production KW - Speech perception KW - Non-speech KW - Brain mapping KW - speech KW - Hemispheric laterality KW - Neuroimaging KW - Perception KW - Acoustics KW - Functional magnetic resonance imaging KW - speech perception KW - Functional anatomy KW - Sampling KW - Brain architecture KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20674292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Common+neural+substrates+support+speech+and+non-speech+vocal+tract+gestures&rft.au=Chang%2C+Soo-Eun%3BKenney%2C+Mary+Kay%3BLoucks%2C+Torrey+MJ%3BPoletto%2C+Christopher+J%3BLudlow%2C+Christy+L&rft.aulast=Chang&rft.aufirst=Soo-Eun&rft.date=2009-08-01&rft.volume=47&rft.issue=1&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.03.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Hemispheric laterality; speech; Acoustics; Perception; Functional magnetic resonance imaging; speech perception; Sampling; Functional anatomy; Brain architecture DO - http://dx.doi.org/10.1016/j.neuroimage.2009.03.032 ER - TY - JOUR T1 - Mitochondrial factors in the regulation of innate immunity AN - 20233877; 10320690 AB - Viral infection stimulates multiple signalling pathways in the innate immune system, leading to type 1 interferon production. Recent research has identified the mitochondrial protein MAVS as a key component of one intracellular pathway, definitively linking mitochondria to the mammalian antiviral defence system for the first time. JF - Microbes and Infection AU - Scott, Iain AD - Molecular Biology Section, Translational Medicine Branch, National Heart Lung and Blood Institute, Building 10-CRC, Room 5-3216,National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, scotti@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 729 EP - 736 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 11 IS - 8-9 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Immune system KW - Mitochondria KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20233877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Mitochondrial+factors+in+the+regulation+of+innate+immunity&rft.au=Scott%2C+Iain&rft.aulast=Scott&rft.aufirst=Iain&rft.date=2009-08-01&rft.volume=11&rft.issue=8-9&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2009.04.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mitochondria DO - http://dx.doi.org/10.1016/j.micinf.2009.04.022 ER - TY - JOUR T1 - Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3 AN - 20221510; 10320713 AB - The innate immune system is triggered when pathogen-associated molecular patterns (PAMPs) expressed by infectious microorganisms interact with toll-like receptors (TLR) present on immune cells. Individual TLRs signal through distinct molecular pathways. For example, TLR9 interacts with unmethylated CpG motifs expressed by bacterial DNA and triggers via a MyD88 dependent pathway whereas TLR3 recognizes viral RNA through a MyD88-independent pathway. Bioinformatic analysis of microarray data was used to identify the regulatory patterns underlying changes in gene expression induced when RAW 264.7 macrophages were stimulated via TLR9 by CpG oligonucleotides (ODN) and/or via TLR3 by poly (I:C). While the genes activated by each ligand mediated similar functions, poly (I:C) elicited a larger and more diverse change in gene expression. Co-stimulation with both ligands accelerated gene expression and synergistically activated genes primarily associated with immune function. This is the first work to compare global changes in gene regulation triggered by distinct TLR pathways and clarify their impact on gene expression. JF - Molecular Immunology AU - Tross, Debra AU - Petrenko, Lev AU - Klaschik, Sven AU - Zhu, Qing AU - Klinman, Dennis M AD - Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, United States, klinmand@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 2557 EP - 2564 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 13 SN - 0161-5890, 0161-5890 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Bioinformatics KW - Toll-like receptors KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - G 07770:Bacteria KW - V 22310:Genetics, Taxonomy & Structure KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20221510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Immunology&rft.atitle=Global+changes+in+gene+expression+and+synergistic+interactions+induced+by+TLR9+and+TLR3&rft.au=Tross%2C+Debra%3BPetrenko%2C+Lev%3BKlaschik%2C+Sven%3BZhu%2C+Qing%3BKlinman%2C+Dennis+M&rft.aulast=Tross&rft.aufirst=Debra&rft.date=2009-08-01&rft.volume=46&rft.issue=13&rft.spage=2557&rft.isbn=&rft.btitle=&rft.title=Molecular+Immunology&rft.issn=01615890&rft_id=info:doi/10.1016%2Fj.molimm.2009.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Toll-like receptors DO - http://dx.doi.org/10.1016/j.molimm.2009.05.011 ER - TY - JOUR T1 - Lipid-derived free radical production in superantigen-induced interstitial pneumonia AN - 20208971; 10140543 AB - We studied the free radical generation involved in the development of interstitial pneumonia (IP) in an animal model of autoimmune disease. We observed an electron spin resonance (ESR) spectrum of alpha -(4-pyridyl- 1-oxide)-N-tert-butylnitrone (POBN) radical adducts detected in the lipid extract of lungs in autoimmune-prone mice after intratracheal instillation of staphylococcal enterotoxin B. The POBN adducts detected by ESR were paralleled by infiltration of macrophages and neutrophils into the bronchoalveolar lavage fluid. To further investigate the mechanism of free radical generation, mice were pretreated with the macrophage toxicant gadolinium chloride, which significantly suppressed the radical generation. Free radical generation was also decreased by pretreatment with the xanthine oxidase (XO) inhibitor allopurinol, the iron chelator Desferal, and the inducible nitric oxide synthase (iNOS) inhibitor 1400W. Histopathologically, these drugs significantly reduced both the cell infiltration into the alveolar septal walls and the synthesis of pulmonary collagen fibers. Experiments with NADPH oxidase knockout mice showed that NADPH oxidase did not contribute to lipid radical generation. These results suggest that lipid-derived carbon- centered free radical production is important in the manifestation of IP and that a macrophage toxicant, an XO inhibitor, an iron chelator, and an iNOS inhibitor protect against both radical generation and the manifestation of IP. JF - Free Radical Biology and Medicine AU - Miyakawa, Hisako AU - Mason, Ronald P AU - Jiang, JinJie AU - Kadiiska, Maria B AD - Free Radical Metabolite Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, kadiiska@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 241 EP - 249 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 47 IS - 3 SN - 0891-5849, 0891-5849 KW - Microbiology Abstracts B: Bacteriology KW - Autoimmune disease KW - Interstitial pneumonia KW - Superantigen KW - Lipid-derived carbon-centered free radical KW - ESR spin trapping KW - Free radicals KW - Macrophages KW - Toxicants KW - Lipids KW - Gadolinium KW - Autoimmune diseases KW - Animal models KW - Chloride KW - Chelating agents KW - Collagen KW - Bronchus KW - NAD(P)H oxidase KW - Trachea KW - Drugs KW - Adducts KW - Leukocytes (neutrophilic) KW - Staphylococcal enterotoxin B KW - Alveoli KW - Nitric-oxide synthase KW - Fibers KW - allopurinol KW - Lung KW - Xanthine oxidase KW - Iron KW - Pneumonia KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20208971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Lipid-derived+free+radical+production+in+superantigen-induced+interstitial+pneumonia&rft.au=Miyakawa%2C+Hisako%3BMason%2C+Ronald+P%3BJiang%2C+JinJie%3BKadiiska%2C+Maria+B&rft.aulast=Miyakawa&rft.aufirst=Hisako&rft.date=2009-08-01&rft.volume=47&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2009.04.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Toxicants; Lipids; Autoimmune diseases; Gadolinium; Animal models; Chloride; Chelating agents; Collagen; Bronchus; NAD(P)H oxidase; Drugs; Trachea; Adducts; Free radicals; Leukocytes (neutrophilic); Staphylococcal enterotoxin B; Alveoli; Nitric-oxide synthase; Fibers; allopurinol; Lung; Xanthine oxidase; Iron; Pneumonia DO - http://dx.doi.org/10.1016/j.freeradbiomed.2009.04.017 ER - TY - JOUR T1 - Hundreds of microsatellites for genotyping Plasmodium yoelii parasites AN - 20188674; 10191989 AB - Genetic crosses have been employed to study various traits of rodent malaria parasites and to locate loci that contribute to drug resistance, immune protection, and disease virulence. Compared with human malaria parasites, genetic crossing of rodent malaria parasites is more easily performed; however, genotyping methods using microsatellites (MSs) or large-scale single nucleotide polymorphisms (SNPs) that have been widely used in typing Plasmodium falciparum are not available for rodent malaria species. Here we report a genome-wide search of the Plasmodium yoelii yoelii (P. yoelii) genome for simple sequence repeats (SSRs) and the identification of nearly 600 polymorphic MS markers for typing the genomes of P. yoelii and Plasmodium berghei. The MS markers are randomly distributed across the 14 physical chromosomes assembled from genome sequences of three rodent malaria species, although some variations in the numbers of MS expected according to chromosome size exist. The majority of the MS markers are AT-rich repeats, similar to those found in the P. falciparum genome. The MS markers provide an important resource for genotyping, lay a foundation for developing linkage maps, and will greatly facilitate genetic studies of P. yoelii. JF - Molecular and Biochemical Parasitology AU - Li, Jian AU - Zhang, Yanhui AU - Liu, Shengfa AU - Hong, Lingxian AU - Sullivan, Margery AU - McCutchan, Thomas F AU - Carlton, Jane M AU - Su, Xin-Zhuan AD - Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Science, Xiamen University, Xiamen, Fujian 361005, People's Republic of China, xsu@niaid.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 153 EP - 158 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 166 IS - 2 SN - 0166-6851, 0166-6851 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Q5 01522:Protective measures and control KW - G 07720:Immunogenetics KW - Q1 01484:Species interactions: parasites and diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20188674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=Hundreds+of+microsatellites+for+genotyping+Plasmodium+yoelii+parasites&rft.au=Li%2C+Jian%3BZhang%2C+Yanhui%3BLiu%2C+Shengfa%3BHong%2C+Lingxian%3BSullivan%2C+Margery%3BMcCutchan%2C+Thomas+F%3BCarlton%2C+Jane+M%3BSu%2C+Xin-Zhuan&rft.aulast=Li&rft.aufirst=Jian&rft.date=2009-08-01&rft.volume=166&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2009.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.molbiopara.2009.03.011 ER - TY - JOUR T1 - Gold nanoparticle-based enhanced chemiluminescence immunosensor for detection of Staphylococcal Enterotoxin B (SEB) in food AN - 20154991; 10279945 AB - Staphylococcal enterotoxins (SEs) are major cause of foodborne diseases, so sensitive detection (< 1 ng/ml) methods are needed for SE detection in food. The surface area, geometric and physical properties of gold nanoparticles make them well-suited for enhancing interactions with biological molecules in assays. To take advantage of the properties of gold nanoparticles for immunodetection, we have developed a gold nanoparticle-based enhanced chemiluminescence (ECL) immunosensor for detection of Staphylococcal Enterotoxin B (SEB) in food. Anti-SEB primary antibodies were immobilized onto a gold nanoparticle surface through physical adsorption and then the antibody-gold nanoparticle mixture was immobilized onto a polycarbonate surface. SEB was detected by a "sandwich-type" ELISA assay on the polycarbonate surface with a secondary antibody and ECL detection. The signal from ECL was read using a point-of-care detector based on a cooled charge-coupled device (CCD) sensor or a plate reader. The system was used to test for SEB in buffer and various foods (mushrooms, tomatoes, and baby food meat). The limit of detection was found to be 6 0.01 ng/mL, which is 6 10 times more sensitive than traditional ELISA. The gold nanoparticles were relatively easy to use for antibody immobilization because of their physical adsorption mechanism; no other reagents were required for immobilization. The use of our simple and inexpensive detector combined with the gold nanoparticle-based ECL method described here is adaptable to simplify and increase sensitivity of any immunological assay and for point-of-care diagnostics. JF - International Journal of Food Microbiology AU - Yang, Minghui AU - Kostov, Yordan AU - Bruck, Hugh A AU - Rasooly, Avraham AD - Center for Advanced Sensor Technology, University of Maryland Baltimore County, MD 21250, United States, rasoolya@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 265 EP - 271 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 133 IS - 3 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology KW - Adsorption KW - Lycopersicon esculentum KW - Gold KW - J 02330:Biochemistry KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20154991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Gold+nanoparticle-based+enhanced+chemiluminescence+immunosensor+for+detection+of+Staphylococcal+Enterotoxin+B+%28SEB%29+in+food&rft.au=Yang%2C+Minghui%3BKostov%2C+Yordan%3BBruck%2C+Hugh+A%3BRasooly%2C+Avraham&rft.aulast=Yang&rft.aufirst=Minghui&rft.date=2009-08-01&rft.volume=133&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.05.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Gold; Lycopersicon esculentum DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.05.029 ER - TY - JOUR T1 - A comparative study of the 1918-1920 influenza pandemic in Japan, USA and UK: mortality impact and implications for pandemic planning AN - 20080764; 10208257 AB - Historical studies of influenza pandemics can provide insight into transmission and mortality patterns, and may aid in planning for a future pandemic. Here, we analyse historical vital statistics and quantify the age-specific mortality patterns associated with the 1918-1920 influenza pandemic in Japan, USA, and UK. All three countries showed highly elevated mortality risk in young adults relative to surrounding non-pandemic years. By contrast, the risk of death was low in the very young and very old. In Japan, the overall mortality impact was not limited to winter 1918-1919, and continued during winter 1919-1920. Mortality impact varied as much as threefold across the 47 Japanese prefectures, and differences in baseline mortality, population demographics, and density explained a small fraction of these variations. Our study highlights important geographical variations in timing and mortality impact of historical pandemics, in particular between the Eastern and Western hemispheres. In a future pandemic, vaccination in one region could save lives even months after the emergence of a pandemic virus in another region. JF - Epidemiology and Infection AU - Richard, Sa AU - Sugaya, N AU - Simonsen, L AU - Miller, Ma AU - Viboud, C Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1062 EP - 1072 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU UK VL - 137 IS - 8 SN - 0950-2688, 0950-2688 KW - Virology & AIDS Abstracts; Risk Abstracts KW - British Isles KW - demography KW - Historical account KW - Mortality KW - Statistics KW - comparative studies KW - Population density KW - young adults KW - Mortality patterns KW - Vaccination KW - influenza KW - Influenza KW - Demography KW - USA KW - pandemics KW - winter KW - Risk factors KW - Geographical variations KW - Japan KW - vital statistics KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20080764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=A+comparative+study+of+the+1918-1920+influenza+pandemic+in+Japan%2C+USA+and+UK%3A+mortality+impact+and+implications+for+pandemic+planning&rft.au=Richard%2C+Sa%3BSugaya%2C+N%3BSimonsen%2C+L%3BMiller%2C+Ma%3BViboud%2C+C&rft.aulast=Richard&rft.aufirst=Sa&rft.date=2009-08-01&rft.volume=137&rft.issue=8&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268809002088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; Influenza; Mortality; pandemics; Statistics; Risk factors; Population density; Geographical variations; Vaccination; demography; Historical account; winter; comparative studies; young adults; Mortality patterns; vital statistics; influenza; British Isles; USA; Japan DO - http://dx.doi.org/10.1017/S0950268809002088 ER -